Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADAM30	11085	broad.mit.edu	37	1	120438863	120438863	+	Missense_Mutation	SNP	G	G	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr1:120438863G>A	ENST00000369400.1	-	1	255	c.97C>T	c.(97-99)Cac>Tac	p.H33Y		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	33					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		CCTTCAGGGTGAAAAATTACA	0.512000													42	18					0	0	0.104719	0	0
C3orf20	84077	broad.mit.edu	37	3	14731559	14731559	+	Silent	SNP	C	C	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr3:14731559C>T	ENST00000253697.3	+	5	1133	c.681C>T	c.(679-681)taC>taT	p.Y227Y	C3orf20_ENST00000435614.1_Silent_p.Y105Y|C3orf20_ENST00000412910.1_Silent_p.Y105Y	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	227						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AGCTGATCTACCACTCTTCCA	0.468000													11	61					0	0	0.080935	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092371	30092371	+	RNA	SNP	C	C	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr18:30092371C>T	ENST00000567636.1	+	0	746					NR_003558.1																						CTTCTTGGGACGTGGTGTTCC	0.557000													21	38					0	0	0.062417	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90161168	90161168	+	RNA	SNP	T	T	G	rs8055740		TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr16:90161168T>G	ENST00000564451.1	+	0	894				TUBB8P7_ENST00000567960.1_RNA																							CCTCCTGTCCTCCGAGTCGAG	0.622000													3	12					0	0	0.021553	0	0
HYAL4	23553	broad.mit.edu	37	7	123516948	123516948	+	Silent	SNP	C	C	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr7:123516948C>T	ENST00000223026.4	+	5	1823	c.1185C>T	c.(1183-1185)ccC>ccT	p.P395P	HYAL4_ENST00000476325.1_Silent_p.P395P	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	395					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						GGAACGCGCCCAGTTACCTTC	0.512000													57	82					0	0	0.139131	0	0
NGLY1	55768	broad.mit.edu	37	3	25761622	25761622	+	Missense_Mutation	SNP	C	C	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr3:25761622C>A	ENST00000428257.1	-	11	1725	c.1618G>T	c.(1618-1620)Ggg>Tgg	p.G540W	NGLY1_ENST00000467224.1_5'UTR|NGLY1_ENST00000280700.5_Missense_Mutation_p.G558W|NGLY1_ENST00000396649.3_Intron|NGLY1_ENST00000417874.2_Missense_Mutation_p.G516W|NGLY1_ENST00000422724.2_3'UTR	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	558	PAW.				glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						CCAACTGACCCACACTCAAAC	0.398000													17	121					4.75885e-15	5.71062e-15	0.033300	1	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112899854	112899854	+	Missense_Mutation	SNP	T	T	C			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr9:112899854T>C	ENST00000374530.3	+	8	2210	c.2030T>C	c.(2029-2031)gTg>gCg	p.V677A	PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.V677A|AKAP2_ENST00000434623.2_Missense_Mutation_p.V535A|AKAP2_ENST00000374525.1_Missense_Mutation_p.V535A|AKAP2_ENST00000259318.7_Missense_Mutation_p.V446A|AKAP2_ENST00000555236.1_Missense_Mutation_p.V677A|AKAP2_ENST00000510514.5_Missense_Mutation_p.V677A	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		446							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						GTCCTCACTGTGGTCAAGGAT	0.527000													12	198					0	0	0.080935	0	0
DOPEY2	9980	broad.mit.edu	37	21	37653832	37653832	+	Missense_Mutation	SNP	T	T	C			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr21:37653832T>C	ENST00000399151.3	+	32	6168	c.6083T>C	c.(6082-6084)aTg>aCg	p.M2028T		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	2028					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CAGAAAGCCATGCTGTTAAAG	0.393000													40	67					0	0	0.086207	0	0
SMARCA5	8467	broad.mit.edu	37	4	144457701	144457701	+	Silent	SNP	A	A	G			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr4:144457701A>G	ENST00000283131.3	+	11	1827	c.1365A>G	c.(1363-1365)aaA>aaG	p.K455K		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	455					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding		EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					AGTTGAGAAAATGTTGTAATC	0.373000													8	108					0	0	0.047766	0	0
FERMT1	55612	broad.mit.edu	37	20	6060186	6060186	+	Missense_Mutation	SNP	G	G	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr20:6060186G>A	ENST00000217289.4	-	14	2545	c.1757C>T	c.(1756-1758)tCa>tTa	p.S586L	FERMT1_ENST00000536936.1_Missense_Mutation_p.S329L|FERMT1_ENST00000478194.1_5'UTR	NM_017671.4	NP_060141.3	Q9BQL6	FERM1_HUMAN	fermitin family member 1	586	FERM.				cell adhesion|establishment of epithelial cell polarity|keratinocyte migration|keratinocyte proliferation	cytosol|focal adhesion|ruffle membrane	binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	17						CCTGTTATATGAAACTCCCAG	0.363000													7	152					0	0	0.038147	0	0
GLDC	2731	broad.mit.edu	37	9	6592871	6592871	+	Missense_Mutation	SNP	G	G	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr9:6592871G>A	ENST00000321612.6	-	10	1531	c.1381C>T	c.(1381-1383)Cgg>Tgg	p.R461W		NM_000170.2	NP_000161.2	P23378	GCSP_HUMAN	glycine dehydrogenase (decarboxylating)	461					glycine catabolic process	mitochondrion	electron carrier activity|glycine dehydrogenase (decarboxylating) activity|lyase activity|pyridoxal phosphate binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Acute lymphoblastic leukemia(23;0.161)		GBM - Glioblastoma multiforme(50;0.0421)|Lung(218;0.134)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TCAAAAAGCCGAAAATTGATC	0.403000													5	104					0	0	0.014758	0	0
LOC101927905	101927905	broad.mit.edu	37	12	8388326	8388326	+	RNA	SNP	G	G	C	rs113732517		TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr12:8388326G>C	ENST00000304751.9	+	0	316				FAM86FP_ENST00000427893.2_RNA																							CGAGCCTCCCGAGGGCTGCAC	0.577000													8	34					0	0	0.047766	0	0
TSGA13	114960	broad.mit.edu	37	7	130357610	130357610	+	Missense_Mutation	SNP	G	G	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr7:130357610G>A	ENST00000456951.1	-	7	1345	c.494C>T	c.(493-495)tCg>tTg	p.S165L	TSGA13_ENST00000356588.3_Missense_Mutation_p.S165L			Q96PP4	TSG13_HUMAN	testis specific, 13	165										endometrium(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	18	Melanoma(18;0.0435)					GGGATCATCCGACAGTATCAA	0.433000													45	74					0	0	0.139131	0	0
RP11-24M17.5	0	broad.mit.edu	37	15	76074504	76074504	+	RNA	SNP	C	C	T	rs146281026	by1000genomes	TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr15:76074504C>T	ENST00000395215.3	+	0	683																											TGAACGCACACGTGACACAGG	0.572000													3	29					0	0	0.115264	0	0
SUCLA2	8803	broad.mit.edu	37	13	48528324	48528324	+	Missense_Mutation	SNP	G	G	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr13:48528324G>A	ENST00000378654.3	-	8	1114	c.1058C>T	c.(1057-1059)aCa>aTa	p.T353I	SUCLA2_ENST00000543413.1_Missense_Mutation_p.T295I|SUCLA2_ENST00000544100.1_Missense_Mutation_p.T219I|SUCLA2_ENST00000534875.1_Missense_Mutation_p.T295I	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	353					succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	TTGATGGACTGTAGCACCACC	0.358000													7	124					0	0	0.029380	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803702	142803702	+	RNA	SNP	A	A	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr1:142803702A>T	ENST00000423385.1	-	0	1263																											ccatcataacatctgtgttcc	0.338000													4	33					0	0	0.009096	0	0
POU6F2	11281	broad.mit.edu	37	7	39500263	39500263	+	Missense_Mutation	SNP	A	A	G			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr7:39500263A>G	ENST00000518318.2	+	9	1562	c.1520A>G	c.(1519-1521)cAg>cGg	p.Q507R	POU6F2_ENST00000403058.1_Missense_Mutation_p.Q507R|POU6F2_ENST00000559001.1_Missense_Mutation_p.Q452R			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	507	POU-specific.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.Q507L(1)|p.Q507R(1)		NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CAGGTGGGACAGGCTCTCAGT	0.602000													5	13					0	0	0.014758	0	0
NUP62CL	54830	broad.mit.edu	37	X	106397335	106397335	+	Missense_Mutation	SNP	A	A	C			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chrX:106397335A>C	ENST00000372466.4	-	5	587	c.336T>G	c.(334-336)aaT>aaG	p.N112K	NUP62CL_ENST00000372461.3_Intron	NM_017681.2	NP_060151.2	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	112					protein transport	nuclear pore	structural constituent of nuclear pore			lung(4)	4						CCATCTCACCATTCTCAATCA	0.378000													11	79					0	0	0.080935	0	0
TRPM4	54795	broad.mit.edu	37	19	49669420	49669420	+	Missense_Mutation	SNP	C	C	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr19:49669420C>A	ENST00000252826.5	+	3	341	c.215C>A	c.(214-216)aCc>aAc	p.T72N	TRPM4_ENST00000355712.5_Intron|TRPM4_ENST00000427978.2_Missense_Mutation_p.T72N	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	72					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GAGAAGCCCACCGATGCCTAC	0.716000													9	4					0.000274275	0.00030856	0.047766	1	0
SCUBE2	57758	broad.mit.edu	37	11	9077430	9077430	+	Missense_Mutation	SNP	T	T	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr11:9077430T>A	ENST00000457346.2	-	10	1191	c.1117A>T	c.(1117-1119)Acc>Tcc	p.T373S	SCUBE2_ENST00000450649.2_Missense_Mutation_p.T373S|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000309263.3_Missense_Mutation_p.T373S|SCUBE2_ENST00000520467.1_Missense_Mutation_p.T373S			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	373	EGF-like 8; calcium-binding (Potential).					extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		TGGTCACAGGTCCTATCCAAA	0.502000													16	217					0	0	0.146539	0	0
GAN	8139	broad.mit.edu	37	16	81391531	81391531	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr16:81391531C>A	ENST00000248272.3	+	5	1130	c.968C>A	c.(967-969)tCa>tAa	p.S323*		NM_022041.3	NP_071324.1	Q9H2C0	GAN_HUMAN	gigaxonin	323					cell death	cytoplasm|neurofilament	protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)	25		Colorectal(91;0.153)				GGAGTTCTCTCAGCAGGTACC	0.448000													42	73					3.76604e-16	4.67508e-16	0.117977	1	0
CCKBR	887	broad.mit.edu	37	11	6292569	6292569	+	Silent	SNP	C	C	T	rs138218747	byFrequency	TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr11:6292569C>T	ENST00000525462.1	+	4	1350	c.1347C>T	c.(1345-1347)taC>taT	p.Y449Y	CCKBR_ENST00000532715.1_Silent_p.Y296Y|CCKBR_ENST00000334619.2_Silent_p.Y380Y			P32239	GASR_HUMAN	cholecystokinin B receptor	380					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TGCTGAGCTACGCCTCGGCCT	0.622000													46	132					0	0	0.124865	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299313	125299313	+	Missense_Mutation	SNP	C	C	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chrX:125299313C>T	ENST00000538699.1	-	2	675	c.595G>A	c.(595-597)Gca>Aca	p.A199T	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.A199T	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	199										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CAGGCGACTGCGAAGATCCAG	0.652000													40	35					0	0	0.117977	0	0
TMC3	342125	broad.mit.edu	37	15	81637115	81637115	+	Missense_Mutation	SNP	C	C	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr15:81637115C>T	ENST00000558726.1	-	13	1648	c.1513G>A	c.(1513-1515)Gtt>Att	p.V505I	RP11-761I4.3_ENST00000560851.1_RNA|RP11-761I4.3_ENST00000559781.1_RNA|TMC3_ENST00000359440.5_Missense_Mutation_p.V504I			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	504						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						ACCTGACCAACGTATGTCTCC	0.478000													5	66					0	0	0.014758	0	0
AHSA1	10598	broad.mit.edu	37	14	77935516	77935516	+	Missense_Mutation	SNP	G	G	T			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr14:77935516G>T	ENST00000216479.3	+	9	1101	c.941G>T	c.(940-942)cGg>cTg	p.R314L	AHSA1_ENST00000555457.1_3'UTR	NM_012111.2	NP_036243.1	O95433	AHSA1_HUMAN	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	314					protein folding|response to stress	cytosol|endoplasmic reticulum	ATPase activator activity|chaperone binding			endometrium(1)|kidney(3)|large_intestine(1)|prostate(1)|skin(1)|stomach(1)	8			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		GAGGAAGAGCGGACGCGACAG	0.577000													58	221					1.44317e-28	1.8555e-28	0.139131	1	0
PJA2	9867	broad.mit.edu	37	5	108698654	108698654	+	Missense_Mutation	SNP	A	A	C			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr5:108698654A>C	ENST00000361189.2	-	6	1778	c.1539T>G	c.(1537-1539)agT>agG	p.S513R	PJA2_ENST00000361557.3_Missense_Mutation_p.S513R	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	513					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		TTCCCTCATCACTGCTGCTTT	0.408000													32	120					0	0	0.059317	0	0
SLC24A2	25769	broad.mit.edu	37	9	19520958	19520960	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr9:19520958_19520960delCGG	ENST00000341998.2	-	9	1729_1731	c.1668_1670delCCG	c.(1666-1671)gcg>gc	p.AR556del	SLC24A2_ENST00000286344.3_In_Frame_Del_p.AR539del	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	556					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		TAACCCCTTCCGGGCCACTATGA	0.507													10	101	---	---	---	---					
USP15	9958	broad.mit.edu	37	12	62708660	62708662	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-B2-3923-01A-01D-1458-08	TCGA-B2-3923-10A-01D-1458-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	055b5dbe-6a29-4ad7-87ce-1b8c4c1211b4	d7f13006-b937-472c-a6cb-5dd7104e7a2f	g.chr12:62708660_62708662delTGT	ENST00000280377.5	+	4	496_498	c.438_440delTGT	c.(436-441)aat>aa	p.NV146del	USP15_ENST00000393654.3_In_Frame_Del_p.NV146del|USP15_ENST00000550632.1_3'UTR|USP15_ENST00000312635.6_In_Frame_Del_p.NV146del|USP15_ENST00000353364.3_In_Frame_Del_p.NV146del	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	146					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		ACATGAATAATGTTGTAACTCGA	0.315													134	246	---	---	---	---