Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CTDP1	9150	broad.mit.edu	37	18	77477556	77477556	+	Missense_Mutation	SNP	C	C	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr18:77477556C>G	ENST00000299543.7	+	9	2237	c.2090C>G	c.(2089-2091)gCa>gGa	p.A697G	CTDP1_ENST00000075430.7_Missense_Mutation_p.A697G	NM_001202504.1|NM_004715.4	NP_001189433.1|NP_004706.3	Q9Y5B0	CTDP1_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	697	BRCT.				positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		GTGCTGCAGGCACAGGAGTGC	0.672000													20	53					0	0	0.592651	0	0
YARS	8565	broad.mit.edu	37	1	33252023	33252023	+	Silent	SNP	T	T	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:33252023T>C	ENST00000373477.4	-	8	1754	c.846A>G	c.(844-846)aaA>aaG	p.K282K		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	282					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	TTCCACCCCATTTCTCATCTC	0.428000													14	37					0	0	0.500413	0	0
RFX1	5989	broad.mit.edu	37	19	14088854	14088854	+	Missense_Mutation	SNP	G	G	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr19:14088854G>C	ENST00000254325.4	-	8	1113	c.879C>G	c.(877-879)agC>agG	p.S293R		NM_002918.4	NP_002909.4	P22670	RFX1_HUMAN	regulatory factor X, 1 (influences HLA class II expression)	293					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			ACTGCACCTGGCTGGAGTACA	0.652000													26	110					0	0	0.693898	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102296140	102296140	+	RNA	SNP	C	C	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr15:102296140C>T	ENST00000561463.1	+	0	4186																											GTCCAACCTGCACTCGCGTGG	0.602000													3	7					0	0	0.184627	0	0
BCL7A	605	broad.mit.edu	37	12	122481898	122481898	+	Silent	SNP	C	C	T	rs111620654	byFrequency	TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr12:122481898C>T	ENST00000538010.1	+	4	3048	c.378C>T	c.(376-378)gaC>gaT	p.D126D	BCL7A_ENST00000261822.4_Silent_p.D126D	NM_020993.3	NP_066273.1	Q4VC05	BCL7A_HUMAN	B-cell CLL/lymphoma 7A	126					negative regulation of transcription, DNA-dependent					haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000202)|Epithelial(86;0.000386)|BRCA - Breast invasive adenocarcinoma(302;0.231)		TGCCCAGCGACGGCACCGAGG	0.642000			T	MYC	BNHL								30	79					0	0	0.717897	0	0
KIAA1715	80856	broad.mit.edu	37	2	176835534	176835534	+	Splice_Site	SNP	T	T	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr2:176835534T>C	ENST00000272748.4	-	6	564		c.e6-2		KIAA1715_ENST00000535310.1_Splice_Site|KIAA1715_ENST00000544803.1_Splice_Site	NM_030650.1	NP_085153.1	Q9C0E8	LNP_HUMAN	KIAA1715							integral to membrane	protein binding			endometrium(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)	20			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			ATGCTTCATCTAGAAAGCAAG	0.234000													3	13					0	0	0.115264	0	0
ATP1A1	476	broad.mit.edu	37	1	116937892	116937892	+	Silent	SNP	A	A	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:116937892A>T	ENST00000537345.1	+	13	2184	c.1821A>T	c.(1819-1821)cgA>cgT	p.R607R	ATP1A1_ENST00000295598.5_Silent_p.R607R|ATP1A1_ENST00000369496.4_Silent_p.R576R	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	607					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	GCAAATGTCGAAGTGCTGGAA	0.522000													19	60					0	0	0.575678	0	0
DMAP1	55929	broad.mit.edu	37	1	44685108	44685108	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:44685108C>A	ENST00000372289.2	+	7	1200	c.937C>A	c.(937-939)Cca>Aca	p.P313T	DMAP1_ENST00000315913.5_Missense_Mutation_p.P313T|DMAP1_ENST00000361745.6_Missense_Mutation_p.P313T|DMAP1_ENST00000488433.1_3'UTR	NM_019100.4	NP_061973.1	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	313					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(166;0.155)					CATCAAGTTTCCAGACTTCAA	0.577000													13	19					3.27435e-08	3.5169e-08	0.457914	1	0
NDOR1	27158	broad.mit.edu	37	9	140110192	140110192	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr9:140110192G>A	ENST00000371521.4	+	11	1453	c.1370G>A	c.(1369-1371)gGg>gAg	p.G457E	NDOR1_ENST00000427047.2_Missense_Mutation_p.G423E|NDOR1_ENST00000344894.5_Missense_Mutation_p.G457E|NDOR1_ENST00000458322.2_Missense_Mutation_p.G450E	NM_001144026.1	NP_001137498.1	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	457					cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding			breast(1)|endometrium(5)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		ATCATGGTGGGGCCTGGCACT	0.667000													4	72					0	0	0.150653	0	0
SYNE3	161176	broad.mit.edu	37	14	95910939	95910939	+	Silent	SNP	A	A	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr14:95910939A>G	ENST00000334258.5	-	9	1673	c.1659T>C	c.(1657-1659)ttT>ttC	p.F553F	SYNE3_ENST00000553340.1_Silent_p.F553F|SYNE3_ENST00000557275.1_Silent_p.F553F|SYNE3_ENST00000554873.1_Silent_p.F310F	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						AAGCTGCTCCAAAGTCTTTGT	0.582000													11	54					0	0	0.411799	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													6	75					0	0	0.217242	0	0
SNX29	92017	broad.mit.edu	37	16	12145807	12145807	+	Missense_Mutation	SNP	G	G	T	rs140388401		TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr16:12145807G>T	ENST00000566228.1	+	8	921	c.852G>T	c.(850-852)aaG>aaT	p.K284N		NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	256	PX.				cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						TGTTTAAAAAGACACCTGGGG	0.483000													31	137					2.08457e-15	2.3251e-15	0.750413	1	0
KCNJ1	3758	broad.mit.edu	37	11	128709679	128709679	+	Missense_Mutation	SNP	A	A	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr11:128709679A>C	ENST00000392665.2	-	2	604	c.460T>G	c.(460-462)Ttc>Gtc	p.F154V	KCNJ1_ENST00000440599.2_Missense_Mutation_p.F154V|KCNJ1_ENST00000324036.3_Missense_Mutation_p.F154V|KCNJ1_ENST00000392664.2_Missense_Mutation_p.F173V|KCNJ1_ENST00000392666.1_Missense_Mutation_p.F154V	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	173					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CCACACATGAAAGAATTGATT	0.453000													28	70					0	0	0.706142	0	0
ANK3	288	broad.mit.edu	37	10	61832058	61832058	+	Missense_Mutation	SNP	T	T	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr10:61832058T>G	ENST00000280772.1	-	37	8772	c.8581A>C	c.(8581-8583)Act>Cct	p.T2861P	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2861					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTATTGTTAGTGGCTCCCGAA	0.413000													25	82					0	0	0.667858	0	0
TOM1L1	10040	broad.mit.edu	37	17	53026926	53026926	+	Silent	SNP	A	A	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr17:53026926A>G	ENST00000575882.1	+	13	1583	c.1230A>G	c.(1228-1230)caA>caG	p.Q410Q	TOM1L1_ENST00000348161.4_Silent_p.Q333Q|TOM1L1_ENST00000445275.2_Silent_p.Q399Q|TOM1L1_ENST00000572158.1_Silent_p.Q403Q|TOM1L1_ENST00000536554.1_Silent_p.Q333Q|TOM1L1_ENST00000540336.1_Silent_p.Q298Q	NM_005486.2	NP_005477.2	O75674	TM1L1_HUMAN	target of myb1 (chicken)-like 1	410					intracellular protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	cytosol|endosome membrane|Golgi stack|lysosome	SH3 domain binding|ubiquitin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	15						TTAGTCTACAAACCATTGCAG	0.388000													12	61					0	0	0.411799	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													6	77					0	0	0.217242	0	0
OR8B3	390271	broad.mit.edu	37	11	124266451	124266451	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr11:124266451G>A	ENST00000354597.3	-	1	813	c.797C>T	c.(796-798)tCt>tTt	p.S266F		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CTGCTCCATAGATCCAGAAGA	0.408000													8	102					0	0	0.387290	0	0
SUGP2	10147	broad.mit.edu	37	19	19121013	19121013	+	Silent	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr19:19121013G>A	ENST00000601879.1	-	5	2286	c.1989C>T	c.(1987-1989)taC>taT	p.Y663Y	SUGP2_ENST00000456085.2_Silent_p.Y432Y|SUGP2_ENST00000600377.1_Silent_p.Y677Y|SUGP2_ENST00000452918.2_Silent_p.Y663Y|SUGP2_ENST00000337018.6_Silent_p.Y663Y			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	663					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CAGCCCGGGAGTACAGCATGG	0.627000													31	193					0	0	0.740014	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65210037	65210037	+	Silent	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr14:65210037G>A	ENST00000247226.7	+	15	3416	c.3108G>A	c.(3106-3108)tcG>tcA	p.S1036S	PLEKHG3_ENST00000484731.2_Silent_p.S597S|PLEKHG3_ENST00000471182.2_Silent_p.S625S|PLEKHG3_ENST00000394691.1_Silent_p.S1092S|PLEKHG3_ENST00000492928.1_Intron	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	1092			R -> W (in dbSNP:rs229649).		regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		CACCTCTGTCGGGCAGGGTGG	0.736000													3	28					0	0	0.115264	0	0
SLC16A1	6566	broad.mit.edu	37	1	113460112	113460112	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:113460112C>T	ENST00000538576.1	-	4	1747	c.916G>A	c.(916-918)Gct>Act	p.A306T	SLC16A1_ENST00000433570.4_Missense_Mutation_p.A306T|SLC16A1_ENST00000369626.3_Missense_Mutation_p.A306T	NM_001166496.1	NP_001159968.1	P53985	MOT1_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 1	306					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|urinary_tract(1)	20	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	TCAACAAAAGCCAGAATGGAA	0.433000													3	43					0	0	0.115264	0	0
DDX55	57696	broad.mit.edu	37	12	124094530	124094530	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr12:124094530G>A	ENST00000238146.4	+	7	646	c.596G>A	c.(595-597)gGc>gAc	p.G199D	DDX55_ENST00000538744.1_Missense_Mutation_p.G199D	NM_020936.1	NP_065987.1	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	199	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		AGGAGAACAGGCCTTTTCTCT	0.547000													16	61					0	0	0.520397	0	0
FOXD4	2298	broad.mit.edu	37	9	117355	117355	+	Silent	SNP	A	A	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr9:117355A>G	ENST00000382500.2	-	1	1062	c.765T>C	c.(763-765)ccT>ccC	p.P255P		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	255	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCAGAGCGTAAGGGCGTCTCC	0.736000													20	17					0	0	0.608945	0	0
CCDC129	223075	broad.mit.edu	37	7	31682489	31682489	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr7:31682489T>C	ENST00000319386.3	+	11	2054	c.1061T>C	c.(1060-1062)aTg>aCg	p.M354T	CCDC129_ENST00000407970.3_Missense_Mutation_p.M502T|CCDC129_ENST00000451887.2_Missense_Mutation_p.M528T|CCDC129_ENST00000409210.1_Missense_Mutation_p.M410T			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	502										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						GTATCTGTGATGGAGGAAGAG	0.542000													29	124					0	0	0.740014	0	0
ITSN1	6453	broad.mit.edu	37	21	35122607	35122607	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr21:35122607T>C	ENST00000381318.3	+	6	794	c.506T>C	c.(505-507)cTg>cCg	p.L169P	ITSN1_ENST00000399367.3_Missense_Mutation_p.L169P|ITSN1_ENST00000399353.1_Missense_Mutation_p.L132P|ITSN1_ENST00000379960.5_Missense_Mutation_p.L169P|ITSN1_ENST00000399352.1_Missense_Mutation_p.L169P|ITSN1_ENST00000399355.2_Missense_Mutation_p.L169P|ITSN1_ENST00000399326.3_Missense_Mutation_p.L169P|ITSN1_ENST00000399338.4_Missense_Mutation_p.L169P|ITSN1_ENST00000381291.4_Missense_Mutation_p.L169P|ITSN1_ENST00000399349.1_Missense_Mutation_p.L169P|ITSN1_ENST00000437442.2_Missense_Mutation_p.L169P|ITSN1_ENST00000381285.4_Missense_Mutation_p.L169P|AP000304.12_ENST00000429238.1_Intron	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	169					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						ATACAACCTCTGCCTGCATTT	0.453000													28	81					0	0	0.779181	0	0
SDAD1	55153	broad.mit.edu	37	4	76882456	76882456	+	Missense_Mutation	SNP	T	T	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr4:76882456T>C	ENST00000356260.5	-	15	1305	c.1187A>G	c.(1186-1188)aAt>aGt	p.N396S	SDAD1_ENST00000513089.1_5'UTR|SDAD1_ENST00000395711.4_Missense_Mutation_p.N359S	NM_018115.2	NP_060585.2	Q9NVU7	SDA1_HUMAN	SDA1 domain containing 1	396				N -> S (in Ref. 1; CAH18368).	protein transport|ribosomal large subunit biogenesis	nucleolus	protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	19			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CTTTATAGCATTGATTCTAGA	0.368000													30	81					0	0	0.750413	0	0
UTRN	7402	broad.mit.edu	37	6	144844257	144844257	+	Nonsense_Mutation	SNP	A	A	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr6:144844257A>T	ENST00000367545.3	+	40	5839	c.5839A>T	c.(5839-5841)Aga>Tga	p.R1947*		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1947					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CATTCAGATCAGAGATACACT	0.378000													17	56					0	0	0.557998	0	0
DDR2	4921	broad.mit.edu	37	1	162740113	162740113	+	Missense_Mutation	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:162740113G>A	ENST00000367922.2	+	13	1753	c.1315G>A	c.(1315-1317)Gat>Aat	p.D439N	DDR2_ENST00000367921.3_Missense_Mutation_p.D439N	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	439					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GATGCTGGATGATGAAATGAC	0.478000													18	147					0	0	0.557998	0	0
PMS2	5395	broad.mit.edu	37	7	6042153	6042153	+	Silent	SNP	T	T	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr7:6042153T>A	ENST00000265849.7	-	5	573	c.468A>T	c.(466-468)acA>acT	p.T156T	PMS2_ENST00000382321.4_Silent_p.T156T|PMS2_ENST00000441476.2_Silent_p.T50T|PMS2_ENST00000406569.3_Silent_p.T156T|PMS2_ENST00000469652.1_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	156					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GCACGCTGACTGTGGTCCCTC	0.468000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				42	96					0	0	0.834066	0	0
MYH8	4626	broad.mit.edu	37	17	10321989	10321989	+	Missense_Mutation	SNP	C	C	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr17:10321989C>A	ENST00000403437.2	-	5	578	c.484G>T	c.(484-486)Gac>Tac	p.D162Y	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	162	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TAGGCATTGTCAGAGATGGAG	0.517000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				57	135					4.66136e-34	5.51753e-34	0.870114	1	0
LRP2	4036	broad.mit.edu	37	2	170062051	170062051	+	Silent	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr2:170062051G>A	ENST00000263816.3	-	41	7938	c.7653C>T	c.(7651-7653)gtC>gtT	p.V2551V		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2551					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACTGGGCATGACCAGACTGC	0.512000													4	82					0	0	0.150653	0	0
SLC1A5	6510	broad.mit.edu	37	19	47278897	47278897	+	Missense_Mutation	SNP	A	A	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr19:47278897A>T	ENST00000542575.2	-	8	2124	c.1496T>A	c.(1495-1497)aTa>aAa	p.I499K	SLC1A5_ENST00000434726.2_Missense_Mutation_p.I297K|SLC1A5_ENST00000412532.2_Missense_Mutation_p.I271K|FKRP_ENST00000600646.1_Intron|SLC1A5_ENST00000594991.1_Missense_Mutation_p.I323K	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	499					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	CTTCACTTGTATCAACTCAGG	0.587000													43	172					0	0	0.847076	0	0
SLC41A1	254428	broad.mit.edu	37	1	205767924	205767924	+	Silent	SNP	G	G	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr1:205767924G>A	ENST00000367137.3	-	6	1731	c.717C>T	c.(715-717)gtC>gtT	p.V239V	SLC41A1_ENST00000468057.1_5'UTR	NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	239						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGCCAATGATGACTCCAATCA	0.537000													28	73					0	0	0.729181	0	0
KNSTRN	90417	broad.mit.edu	37	15	40682113	40682113	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr15:40682113G>T	ENST00000416151.2	+	6	783	c.668G>T	c.(667-669)aGc>aTc	p.S223I	KNSTRN_ENST00000448395.2_Missense_Mutation_p.S223I|KNSTRN_ENST00000249776.8_Missense_Mutation_p.S223I	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		ATTTTGGAGAGCAAGGGCCTT	0.532000													11	59					9.05144e-12	9.90535e-12	0.435327	1	0
SLC39A7	7922	broad.mit.edu	37	6	33170811	33170811	+	Silent	SNP	C	C	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr6:33170811C>T	ENST00000374677.3	+	6	1438	c.1065C>T	c.(1063-1065)gtC>gtT	p.V355V	SLC39A7_ENST00000374675.3_Silent_p.V355V|SLC39A7_ENST00000463972.1_3'UTR	NM_006979.2	NP_008910.2	Q92504	S39A7_HUMAN	solute carrier family 39 (zinc transporter), member 7	355						endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			NS(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						CAATGACTGTCCTGCTACATG	0.562000													64	207					0	0	0.870114	0	0
IGSF10	285313	broad.mit.edu	37	3	151166433	151166433	+	Missense_Mutation	SNP	T	T	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr3:151166433T>A	ENST00000282466.3	-	4	1335	c.1336A>T	c.(1336-1338)Agt>Tgt	p.S446C		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	446					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTAATGTACTGAATGTGGTG	0.423000													28	70					0	0	0.717897	0	0
CCT8L2	150160	broad.mit.edu	37	22	17071901	17071901	+	Missense_Mutation	SNP	G	G	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr22:17071901G>T	ENST00000359963.3	-	1	1799	c.1540C>A	c.(1540-1542)Ctc>Atc	p.L514I		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	514					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACAGTCACGAGCTGTAGCACC	0.498000													8	206					5.18039e-06	5.46296e-06	0.278610	1	0
PRSS3P2	154754	broad.mit.edu	37	7	142482292	142482292	+	RNA	SNP	A	A	C			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr7:142482292A>C	ENST00000603901.1	+	0	672					NR_001296.3																						CCCAGAAGAGAAGGCCTGGAG	0.527000													3	35					0	0	0.387290	0	0
LRRC2	79442	broad.mit.edu	37	3	46563140	46563140	+	Missense_Mutation	SNP	C	C	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr3:46563140C>T	ENST00000395905.3	-	8	1330	c.938G>A	c.(937-939)aGc>aAc	p.S313N	LRRC2_ENST00000296144.3_Missense_Mutation_p.S313N	NM_024512.4	NP_078788.2	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	313										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	17		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		GTCCATAAGGCTTACAAATCT	0.358000													18	37					0	0	0.539581	0	0
HOOK2	29911	broad.mit.edu	37	19	12881984	12881984	+	Silent	SNP	C	C	T			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr19:12881984C>T	ENST00000264827.5	-	9	920	c.750G>A	c.(748-750)gaG>gaA	p.E250E	HOOK2_ENST00000589965.1_Intron|HOOK2_ENST00000397668.3_Silent_p.E250E	NM_001100176.1	NP_001093646.1	Q96ED9	HOOK2_HUMAN	hook microtubule-tethering protein 2	250	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endocytosis|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|protein transport	centrosome|FHF complex|microtubule	identical protein binding|microtubule binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(5)|skin(1)	20						TGAAGTTCTCCTCCTGCAACT	0.672000													8	13					0	0	0.278610	0	0
GRIK2	2898	broad.mit.edu	37	6	102503431	102503432	+	Frame_Shift_Ins	INS	-	-	A			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr6:102503431_102503432insA	ENST00000369138.1	+	15	3028_3029	c.2538_2539insA	c.(2536-2541)tcaaaafs	p.SK846fs	GRIK2_ENST00000421544.1_Frame_Shift_Ins_p.SK846fs|GRIK2_ENST00000318991.6_Frame_Shift_Ins_p.SK846fs|GRIK2_ENST00000413795.1_Frame_Shift_Ins_p.SK846fs|GRIK2_ENST00000369137.3_Frame_Shift_Ins_p.SK770fs|GRIK2_ENST00000369134.4_Frame_Shift_Ins_p.SK797fs	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	846					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.N849fs*12(1)|p.N849fs*14(1)		NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TATACAAATCCAAAAAAAACGC	0.351													7	171	---	---	---	---					
MOAP1	64112	broad.mit.edu	37	14	93650300	93650301	+	Frame_Shift_Ins	INS	-	-	G			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr14:93650300_93650301insG	ENST00000556883.1	-	2	771_772	c.287_288insC	c.(286-288)cgafs	p.R96fs	MOAP1_ENST00000298894.4_Frame_Shift_Ins_p.R96fs			Q96BY2	MOAP1_HUMAN	modulator of apoptosis 1	96					activation of caspase activity|apoptotic nuclear change	cytoplasm	protein homodimerization activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	13		all_cancers(154;0.00528)|Acute lymphoblastic leukemia(33;0.0497)|all_epithelial(191;0.125)|all_neural(303;0.13)		Epithelial(152;0.178)|all cancers(159;0.2)|COAD - Colon adenocarcinoma(157;0.204)		tatctgggtcagggggcttaaa	0.475													49	138	---	---	---	---					
LOC102723841	102723841	broad.mit.edu	37	16	33365420	33365420	+	RNA	DEL	A	A	-			TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr16:33365420delA	ENST00000568520.1	-	0	249																											TACAAACTATAAAAAAACAGA	0.358													4	9	---	---	---	---					
ZNF579	163033	broad.mit.edu	37	19	56089908	56089909	+	In_Frame_Ins	INS	-	-	CCG	rs141478862	by1000genomes	TCGA-B4-5834-01A-11D-1669-08	TCGA-B4-5834-10A-02D-1669-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16c5931c-a751-4e91-a13a-4e8441673119	dff3f173-14b7-4d23-becc-d6436a9e9256	g.chr19:56089908_56089909insCCG	ENST00000325421.4	-	2	1125_1126	c.1097_1098insCGG	c.(1096-1098)gca>gCGGca	p.366_366A>AA		NM_152600.2	NP_689813.2	Q8NAF0	ZN579_HUMAN	zinc finger protein 579	366	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G366_Q367insG(1)		endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9			BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.106)		CTCCGTTCTGCCCTTCTCCCCC	0.748													4	3	---	---	---	---