Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLEC4E	26253	broad.mit.edu	37	12	8693386	8693386	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr12:8693386G>A	ENST00000299663.3	-	1	173	c.8C>T	c.(7-9)tCa>tTa	p.S3L	CLEC4E_ENST00000545274.1_Missense_Mutation_p.S3L|CLEC4E_ENST00000446457.2_Missense_Mutation_p.S3L	NM_014358.2	NP_055173.1	Q9ULY5	CLC4E_HUMAN	C-type lectin domain family 4, member E	3						integral to membrane	sugar binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	12	Lung SC(5;0.184)					TGATTTAGATGAATTCATTTT	0.363000													36	204					0	0	0.769981	0	0
TRIOBP	11078	broad.mit.edu	37	22	38119653	38119653	+	Missense_Mutation	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr22:38119653C>G	ENST00000406386.3	+	7	1345	c.1090C>G	c.(1090-1092)Ccc>Gcc	p.P364A	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	364					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GCAGGACAACCCCCAAACTTC	0.572000													36	183					0	0	0.812448	0	0
MICU3	286097	broad.mit.edu	37	8	16948087	16948087	+	Silent	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:16948087T>A	ENST00000318063.5	+	8	924	c.882T>A	c.(880-882)acT>acA	p.T294T		NM_181723.2	NP_859074.1			mitochondrial calcium uptake family, member 3																		ATTCTCCTACTAATAGTGTAT	0.328000													13	462					0	0	0.457914	0	0
ZFAND4	93550	broad.mit.edu	37	10	46159260	46159260	+	Translation_Start_Site	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:46159260T>C	ENST00000374366.3	-	0	55				ZFAND4_ENST00000374371.2_De_novo_Start_OutOfFrame|ZFAND4_ENST00000335258.7_De_novo_Start_OutOfFrame|ZFAND4_ENST00000344646.5_De_novo_Start_OutOfFrame			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4								zinc ion binding										ATTGGTAATATATATTGTTGT	0.303000													2	15					0	0	0.115264	0	0
GAREM	64762	broad.mit.edu	37	18	29890226	29890226	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr18:29890226C>T	ENST00000399218.4	-	3	378	c.323G>A	c.(322-324)aGt>aAt	p.S108N	GAREM_ENST00000578619.1_5'UTR|GAREM_ENST00000269209.6_Missense_Mutation_p.S108N	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		CTCCTCCACACTGTTGAAATA	0.418000													6	290					0	0	0.217242	0	0
ISOC1	51015	broad.mit.edu	37	5	128448671	128448671	+	Missense_Mutation	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:128448671T>A	ENST00000173527.5	+	5	890	c.874T>A	c.(874-876)Tcg>Acg	p.S292T		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	292						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		TGCTCCAGAGTCGGGTCTGCT	0.468000													38	183					0	0	0.834066	0	0
SMU1	55234	broad.mit.edu	37	9	33071759	33071759	+	Missense_Mutation	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr9:33071759C>G	ENST00000397149.3	-	3	419	c.369G>C	c.(367-369)agG>agC	p.R123S	SMU1_ENST00000536631.1_Intron	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	123						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		CAAAGTAAGACCTGGCCAAAA	0.378000													36	134					0	0	0.819951	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361635	105361635	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:105361635G>A	ENST00000297581.2	+	2	904	c.855G>A	c.(853-855)ccG>ccA	p.P285P	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	285					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											CTTTCTGGCCGACTCCTAAAG	0.478000													36	203					0	0	0.796494	0	0
C5AR1	728	broad.mit.edu	37	19	47823040	47823040	+	Missense_Mutation	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr19:47823040C>G	ENST00000355085.3	+	2	28	c.6C>G	c.(4-6)gaC>gaG	p.D2E		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	2			D -> N (in dbSNP:rs4467185).		activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		CCCCTTAGGACTCCTTCAATT	0.537000													8	117					0	0	0.335167	0	0
RPRD2	23248	broad.mit.edu	37	1	150445505	150445505	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:150445505G>T	ENST00000401000.4	+	10	4068	c.4003G>T	c.(4003-4005)Ggc>Tgc	p.G1335C	RPRD2_ENST00000369068.4_Missense_Mutation_p.G1361C|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1361	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CAACGGCCCTGGCCTTAGCCG	0.647000													15	64					3.45872e-05	3.82601e-05	0.500413	1	0
L3MBTL2	83746	broad.mit.edu	37	22	41613163	41613163	+	Missense_Mutation	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr22:41613163A>G	ENST00000216237.5	+	5	715	c.557A>G	c.(556-558)aAg>aGg	p.K186R	RP4-756G23.5_ENST00000441316.1_RNA|RP4-756G23.5_ENST00000451176.1_RNA|L3MBTL2_ENST00000489136.1_3'UTR	NM_031488.4	NP_113676.2	Q969R5	LMBL2_HUMAN	l(3)mbt-like 2 (Drosophila)	186					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	methylated histone residue binding|transcription corepressor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(4)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AAGTTCCTGAAGGATCACAGT	0.632000													26	102					0	0	0.729181	0	0
C10orf137	26098	broad.mit.edu	37	10	127422205	127422205	+	Splice_Site	SNP	A	A	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:127422205A>T	ENST00000337623.3	+	10	1281	c.1174_splice	c.e10-1	p.A392_splice	C10orf137_ENST00000356792.4_Splice_Site_p.A426_splice	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TCTTTTCAGCAAGTGGCAGCG	0.368000													15	129					0	0	0.500413	0	0
FRY	10129	broad.mit.edu	37	13	32811616	32811616	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr13:32811616G>A	ENST00000380250.3	+	44	6407	c.5911G>A	c.(5911-5913)Gca>Aca	p.A1971T		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1971					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CGGCAACACCGCAACTGCCGA	0.537000													3	47					0	0	0.115264	0	0
ACAP1	9744	broad.mit.edu	37	17	7246852	7246852	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:7246852C>T	ENST00000158762.3	+	6	705	c.499C>T	c.(499-501)Cgg>Tgg	p.R167W	ACAP1_ENST00000573893.1_3'UTR	NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	167	BAR.|Required for formation of endosomal tubules when overexpressed with PIP5K1C.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						AGCTGGGTACCGGGGACGGGC	0.657000													13	72					0	0	0.435327	0	0
MYO1B	4430	broad.mit.edu	37	2	192141693	192141693	+	Silent	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:192141693A>G	ENST00000392318.3	+	2	319	c.72A>G	c.(70-72)gaA>gaG	p.E24E	MYO1B_ENST00000339514.4_Silent_p.E24E|MYO1B_ENST00000392316.1_Silent_p.E24E|MYO1B_ENST00000304164.4_Silent_p.E24E	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	24	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			TTCTTTTAGAACCTCTCAATG	0.438000													33	195					0	0	0.760397	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85460535	85460535	+	Missense_Mutation	SNP	A	A	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr12:85460535A>T	ENST00000393217.2	+	10	2615	c.2554A>T	c.(2554-2556)Att>Ttt	p.I852F		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	852										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GGAAAACCATATTGAGGCTAT	0.299000													20	102					0	0	0.624587	0	0
TSC22D3	1831	broad.mit.edu	37	X	106957762	106957762	+	Missense_Mutation	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chrX:106957762C>G	ENST00000372383.4	-	3	957	c.590G>C	c.(589-591)gGt>gCt	p.G197A	TSC22D3_ENST00000315660.4_Missense_Mutation_p.G197A|TSC22D3_ENST00000372382.4_Missense_Mutation_p.G107A|TSC22D3_ENST00000372397.2_Missense_Mutation_p.G131A|TSC22D3_ENST00000506081.1_Missense_Mutation_p.G197A|TSC22D3_ENST00000514426.1_Missense_Mutation_p.G129A|TSC22D3_ENST00000372390.4_Missense_Mutation_p.G74A|TSC22D3_ENST00000372384.2_Missense_Mutation_p.G197A	NM_198057.2	NP_932174.1	Q99576	T22D3_HUMAN	TSC22 domain family, member 3	131							sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)|lung(3)	6						CACCGCAGAACCACCAGGGGC	0.557000													19	35					0	0	0.557998	0	0
SYT6	148281	broad.mit.edu	37	1	114680517	114680517	+	Missense_Mutation	SNP	G	G	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:114680517G>C	ENST00000393296.1	-	3	748	c.671C>G	c.(670-672)tCt>tGt	p.S224C	SYT6_ENST00000369547.1_Missense_Mutation_p.S139C			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	224					acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTGGCCTCAGACTTGGCATC	0.567000													23	96					0	0	0.667858	0	0
DGKE	8526	broad.mit.edu	37	17	54939989	54939989	+	Missense_Mutation	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:54939989C>G	ENST00000284061.3	+	12	1721	c.1541C>G	c.(1540-1542)tCc>tGc	p.S514C		NM_003647.2	NP_003638.1	P52429	DGKE_HUMAN	diacylglycerol kinase, epsilon 64kDa	514					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|phospholipid biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding|protein binding			breast(3)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	25	Breast(9;3.59e-07)					TTGAAGTGCTCCATGATGCCA	0.438000													3	24					0	0	0.115264	0	0
FUS	2521	broad.mit.edu	37	16	31196376	31196376	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr16:31196376G>A	ENST00000254108.7	+	6	745	c.640G>A	c.(640-642)Gga>Aga	p.G214R	FUS_ENST00000380244.3_Missense_Mutation_p.G213R|FUS_ENST00000568685.1_Missense_Mutation_p.G214R	NM_001170634.1|NM_001170937.1|NM_004960.3	NP_001164105.1|NP_001164408.1|NP_004951.1	P35637	FUS_HUMAN	fused in sarcoma	214	Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/ERG(167)|FUS/DDIT3(631)|FUS/FEV(2)|FUS/ATF1(4)|FUS/CREB3L1(6)|FUS/CREB3L2(158)	breast(3)|endometrium(5)|kidney(3)|large_intestine(1)|lung(5)|prostate(3)|skin(1)|urinary_tract(1)	22		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		GCAGGACCGTGGAggccgcgg	0.652000			T	"""DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1"""	"""liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma"""								3	16					0	0	0.184627	0	0
STOX1	219736	broad.mit.edu	37	10	70645316	70645316	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:70645316G>A	ENST00000298596.6	+	3	1847	c.1764G>A	c.(1762-1764)caG>caA	p.Q588Q	STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399169.4_Silent_p.Q588Q|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000421961.2_Silent_p.Q478Q	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	588						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						ACCCTCAACAGAGCATGTTGC	0.393000													4	184					0	0	0.150653	0	0
MAPKAPK2	9261	broad.mit.edu	37	1	206905036	206905036	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:206905036C>A	ENST00000367103.3	+	8	1137	c.944C>A	c.(943-945)aCc>aAc	p.T315N	MAPKAPK2_ENST00000294981.4_Missense_Mutation_p.T315N|MAPKAPK2_ENST00000479009.1_3'UTR	NM_004759.4|NM_032960.3	NP_004750.1|NP_116584.2	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated protein kinase 2	315	Protein kinase.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	19	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			CAGAGAATGACCATCACCGAG	0.562000													46	211					1.39843e-22	1.73073e-22	0.870114	1	0
KIF20B	9585	broad.mit.edu	37	10	91514386	91514386	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:91514386T>C	ENST00000416354.1	+	26	4621	c.4549T>C	c.(4549-4551)Tat>Cat	p.Y1517H	KIF20B_ENST00000260753.4_Missense_Mutation_p.Y1447H|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000371728.3_Missense_Mutation_p.Y1487H|KIF20B_ENST00000394289.2_Missense_Mutation_p.Y1487H			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1487					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						GATGAAAAAATATGCTGAGGA	0.318000													3	118					0	0	0.150653	0	0
SLC24A4	123041	broad.mit.edu	37	14	92915516	92915516	+	Missense_Mutation	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr14:92915516A>G	ENST00000532405.1	+	10	1062	c.836A>G	c.(835-837)tAt>tGt	p.Y279C	SLC24A4_ENST00000298877.1_Missense_Mutation_p.Y262C|SLC24A4_ENST00000393265.2_Missense_Mutation_p.Y215C|SLC24A4_ENST00000531433.1_Intron|SLC24A4_ENST00000351924.5_Intron			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	279						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		AATGATTTCTATGACGGTAGC	0.498000													3	57					0	0	0.150653	0	0
DARS2	55157	broad.mit.edu	37	1	173826679	173826679	+	Missense_Mutation	SNP	G	G	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:173826679G>C	ENST00000361951.4	+	17	2501	c.1774G>C	c.(1774-1776)Gtc>Ctc	p.V592L	DARS2_ENST00000471476.1_3'UTR|DARS2_ENST00000239457.5_Missense_Mutation_p.V137L	NM_018122.4	NP_060592.2	Q6PI48	SYDM_HUMAN	aspartyl-tRNA synthetase 2, mitochondrial	592					tRNA aminoacylation for protein translation	mitochondrial matrix|nucleus	aspartate-tRNA ligase activity|ATP binding|nucleic acid binding			breast(4)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	30					L-Aspartic Acid(DB00128)	GATATGCCTTGTCACTGGATC	0.408000													3	185					0	0	0.115264	0	0
MALAT1	378938	broad.mit.edu	37	11	65273446	65273446	+	RNA	SNP	G	G	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr11:65273446G>C	ENST00000534336.1	+	0	8214					NR_002819.2																						ACTTGGCCAAGCTAGCATCTT	0.428000													23	113					0	0	0.654019	0	0
XPO7	23039	broad.mit.edu	37	8	21824497	21824497	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:21824497C>A	ENST00000434536.1	+	2	250	c.148C>A	c.(148-150)Ctc>Atc	p.L50I	XPO7_ENST00000433566.4_Missense_Mutation_p.L51I|XPO7_ENST00000252512.9_Missense_Mutation_p.L50I|XPO7_ENST00000518017.1_3'UTR			Q9UIA9	XPO7_HUMAN	exportin 7	50	Importin N-terminal.				mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		GTGCCAGCTACTCCTCGAAAG	0.478000													19	130					2.89027e-11	3.40833e-11	0.624587	1	0
ELAVL3	1995	broad.mit.edu	37	19	11565539	11565539	+	Silent	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr19:11565539C>T	ENST00000359227.3	-	7	1330	c.906G>A	c.(904-906)caG>caA	p.Q302Q	ELAVL3_ENST00000438662.2_Silent_p.Q295Q	NM_001420.3|NM_032281.2	NP_001411.2|NP_115657.2	Q14576	ELAV3_HUMAN	ELAV like neuron-specific RNA binding protein 3	302	RRM 3.				cell differentiation|nervous system development		AU-rich element binding|nucleotide binding			breast(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15						GCCCGAACAGCTGCCACAGCA	0.632000													3	79					0	0	0.115264	0	0
F13A1	2162	broad.mit.edu	37	6	6225028	6225028	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:6225028G>A	ENST00000264870.3	-	7	1129	c.864C>T	c.(862-864)gtC>gtT	p.V288V		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	288					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	CCGATGGGGGGACGCCATAGG	0.507000													4	157					0	0	0.184627	0	0
MYH7	4625	broad.mit.edu	37	14	23902427	23902427	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr14:23902427C>T	ENST00000355349.3	-	4	373	c.211G>A	c.(211-213)Gtg>Atg	p.V71M		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	71	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCCTCCTTCACGGTCACTGTC	0.577000													7	85					0	0	0.278610	0	0
JMJD6	23210	broad.mit.edu	37	17	74720093	74720093	+	Missense_Mutation	SNP	T	T	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:74720093T>G	ENST00000445478.2	-	3	769	c.566A>C	c.(565-567)gAc>gCc	p.D189A	JMJD6_ENST00000397625.4_Missense_Mutation_p.D189A|JMJD6_ENST00000585429.1_Missense_Mutation_p.D189A	NM_001081461.1	NP_001074930.1	Q6NYC1	JMJD6_HUMAN	jumonji domain containing 6	189	JmjC.				mRNA processing|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine|regulation of nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|RNA splicing|sprouting angiogenesis|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-R2 specific)|histone demethylase activity (H4-R3 specific)|identical protein binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptidyl-lysine 5-dioxygenase activity|single-stranded RNA binding			endometrium(2)|kidney(5)|large_intestine(2)|lung(3)|ovary(2)|skin(2)	16						TCCCAGAGGGTCGATGTGAAT	0.522000													4	169					0	0	0.150653	0	0
GLRX5	51218	broad.mit.edu	37	14	96010330	96010330	+	Silent	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr14:96010330C>T	ENST00000331334.4	+	2	839	c.342C>T	c.(340-342)ctC>ctT	p.L114L	GLRX5_ENST00000553672.1_3'UTR	NM_016417.2	NP_057501.2	Q86SX6	GLRX5_HUMAN	glutaredoxin 5	114	Glutaredoxin.				cell redox homeostasis|hemopoiesis	mitochondrion	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|protein disulfide oxidoreductase activity			large_intestine(1)|lung(1)	2		all_cancers(154;0.135)		Epithelial(152;0.133)|COAD - Colon adenocarcinoma(157;0.21)|all cancers(159;0.212)		AAGTGTACCTCAATGGCGAGT	0.453000													35	128					0	0	0.819951	0	0
FAM86DP	692099	broad.mit.edu	37	3	75475709	75475709	+	RNA	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:75475709T>C	ENST00000459803.1	-	0	820					NR_024241.1													p.I261V(1)									CTCCGCAGGATCCCGACCAGC	0.562000													6	31					0	0	0.278610	0	0
HOXD3	3232	broad.mit.edu	37	2	177033995	177033995	+	Silent	SNP	A	A	C	rs141168805	byFrequency	TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:177033995A>C	ENST00000468418.3	+	3	2243	c.153A>C	c.(151-153)ccA>ccC	p.P51P	HOXD3_ENST00000249440.3_Silent_p.P51P|HOXD3_ENST00000410016.1_Silent_p.P51P			P31249	HXD3_HUMAN	homeobox D3	51					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		AGCCCTACCCACCCCCTGCTG	0.587000													6	41					0	0	0.592651	0	0
TST	7263	broad.mit.edu	37	22	37407193	37407193	+	Missense_Mutation	SNP	C	C	T	rs144544206		TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr22:37407193C>T	ENST00000403892.3	-	2	1503	c.769G>A	c.(769-771)Gtg>Atg	p.V257M	TST_ENST00000249042.3_Missense_Mutation_p.V257M	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)	257	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						GCCAAGGCCACGTGGCAGGCG	0.647000													3	46					0	0	0.115264	0	0
DNAJC10	54431	broad.mit.edu	37	2	183584762	183584762	+	Nonsense_Mutation	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:183584762T>A	ENST00000264065.6	+	4	648	c.233T>A	c.(232-234)tTa>tAa	p.L78*	DNAJC10_ENST00000537515.1_Nonsense_Mutation_p.L78*|DNAJC10_ENST00000469118.1_3'UTR	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	78	J.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GGCGATTTTTTAAAAATAAAT	0.299000													4	110					0	0	0.150653	0	0
PPP3CC	5533	broad.mit.edu	37	8	22397011	22397011	+	Splice_Site	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:22397011G>T	ENST00000240139.5	+	13	1678	c.1351_splice	c.e13+1	p.A451_splice	PPP3CC_ENST00000397775.3_Splice_Site_p.A460_splice|PPP3CC_ENST00000289963.8_Intron	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	451					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		GGCCCGGGAAGGTATGGCCAT	0.423000													18	116					2.89027e-11	3.40833e-11	0.624587	1	0
CCT6B	10693	broad.mit.edu	37	17	33266673	33266673	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:33266673C>A	ENST00000314144.5	-	9	1143	c.1028G>T	c.(1027-1029)tGc>tTc	p.C343F	CCT6B_ENST00000436961.3_Missense_Mutation_p.C298F|CCT6B_ENST00000421975.3_Missense_Mutation_p.C306F	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	343					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				ATGTCCCAAGCAATCTACAGT	0.363000													3	95					0.115264	0.119074	0.115264	1	0
GET4	51608	broad.mit.edu	37	7	926213	926213	+	Missense_Mutation	SNP	G	G	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:926213G>C	ENST00000407192.1	+	2	2600	c.83G>C	c.(82-84)aGt>aCt	p.S28T	GET4_ENST00000265857.3_Missense_Mutation_p.S81T			Q7L5D6	GET4_HUMAN	golgi to ER traffic protein 4 homolog (S. cerevisiae)	81					tail-anchored membrane protein insertion into ER membrane|transport	BAT3 complex	protein binding			breast(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						TAGCAAAACAGTGCAGCAGAC	0.562000													27	148					0	0	0.740014	0	0
NIPBL	25836	broad.mit.edu	37	5	37048673	37048673	+	Nonsense_Mutation	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:37048673T>A	ENST00000282516.8	+	39	7158	c.6659T>A	c.(6658-6660)tTa>tAa	p.L2220*	NIPBL_ENST00000448238.2_Nonsense_Mutation_p.L2220*	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2220					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			AATAATATTTTATCTGATAAG	0.348000													33	164					0	0	0.760397	0	0
KIF15	56992	broad.mit.edu	37	3	44839366	44839366	+	Missense_Mutation	SNP	A	A	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:44839366A>T	ENST00000326047.4	+	10	1165	c.1016A>T	c.(1015-1017)aAt>aTt	p.N339I		NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	339					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		ATAATTGCAAATGTTCATCCT	0.378000													3	113					0	0	0.217242	0	0
POLR1A	25885	broad.mit.edu	37	2	86265841	86265841	+	Missense_Mutation	SNP	A	A	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:86265841A>C	ENST00000263857.6	-	27	4394	c.4016T>G	c.(4015-4017)cTg>cGg	p.L1339R	POLR1A_ENST00000409681.1_Missense_Mutation_p.L1339R			O95602	RPA1_HUMAN	polymerase (RNA) I polypeptide A, 194kDa	1339					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	63						CATGAAGCGCAGGATGTCCTC	0.522000													5	50					0	0	0.184627	0	0
AP2B1	163	broad.mit.edu	37	17	33935330	33935330	+	Missense_Mutation	SNP	A	A	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:33935330A>T	ENST00000262325.7	+	5	1002	c.449A>T	c.(448-450)gAt>gTt	p.D150V	AP2B1_ENST00000312678.8_Missense_Mutation_p.D150V|AP2B1_ENST00000589344.1_Missense_Mutation_p.D150V|AP2B1_ENST00000592545.1_Missense_Mutation_p.D112V|AP2B1_ENST00000538556.1_Missense_Mutation_p.D93V|AP2B1_ENST00000537622.2_Missense_Mutation_p.D150V	NM_001282.2	NP_001273.1	P63010	AP2B1_HUMAN	adaptor-related protein complex 2, beta 1 subunit	150					axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|coated pit|cytosol|endocytic vesicle membrane|plasma membrane	clathrin binding|protein transporter activity			NS(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AAACTCCATGATATCAATGCC	0.433000													41	191					0	0	0.853193	0	0
OR5K1	26339	broad.mit.edu	37	3	98188528	98188528	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:98188528G>A	ENST00000332650.5	+	1	205	c.108G>A	c.(106-108)ctG>ctA	p.L36L		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCATCTATCTGATCACCGTGG	0.433000													57	244					0	0	0.870114	0	0
MUC4	4585	broad.mit.edu	37	3	195509378	195509378	+	Missense_Mutation	SNP	G	G	C	rs71291868		TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:195509378G>C	ENST00000463781.3	-	2	9532	c.9073C>G	c.(9073-9075)Ctt>Gtt	p.L3025V	MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.L3025V|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	773					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTGACATGAAGAGGGGTGGCG	0.582000													3	2					0	0	0.115264	0	0
DMGDH	29958	broad.mit.edu	37	5	78347129	78347129	+	Silent	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:78347129A>G	ENST00000255189.3	-	5	754	c.726T>C	c.(724-726)aaT>aaC	p.N242N	DMGDH_ENST00000380311.4_Intron|DMGDH_ENST00000540686.1_Intron	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	242					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		TCACAATTCTATTTGCTCTCA	0.393000													56	329					0	0	0.870114	0	0
FAM8A1	51439	broad.mit.edu	37	6	17608559	17608559	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:17608559G>T	ENST00000259963.3	+	5	1286	c.1231G>T	c.(1231-1233)Ggg>Tgg	p.G411W		NM_016255.2	NP_057339.1	Q9UBU6	FA8A1_HUMAN	family with sequence similarity 8, member A1	411						integral to membrane				endometrium(1)|large_intestine(2)|lung(3)	6	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.143)	all cancers(50;0.176)|Epithelial(50;0.204)			AAAAAGAAATGGGGTCAGATG	0.393000													28	144					2.12542e-12	2.57939e-12	0.706142	1	0
ANK2	287	broad.mit.edu	37	4	114277003	114277003	+	Missense_Mutation	SNP	A	A	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr4:114277003A>C	ENST00000357077.4	+	38	7282	c.7229A>C	c.(7228-7230)gAa>gCa	p.E2410A	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.E2377A|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2377					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CAAGGGTTAGAACTTGCACTC	0.522000													13	73					0	0	0.411799	0	0
ZNF451	26036	broad.mit.edu	37	6	56997884	56997884	+	Silent	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:56997884C>A	ENST00000370706.4	+	6	713	c.469C>A	c.(469-471)Cga>Aga	p.R157R	RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000416069.2_RNA|ZNF451_ENST00000357489.3_Silent_p.R157R|RP11-203B9.4_ENST00000586053.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|ZNF451_ENST00000491832.2_Silent_p.R157R	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AAGTTCATTCCGAAGAGGAGG	0.393000													4	150					0.150653	0.154358	0.150653	1	0
IK	3550	broad.mit.edu	37	5	140038746	140038746	+	Missense_Mutation	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:140038746T>A	ENST00000417647.2	+	12	1312	c.1173T>A	c.(1171-1173)gaT>gaA	p.D391E		NM_006083.3	NP_006074.2	Q13123	RED_HUMAN	IK cytokine, down-regulator of HLA II	391					cell-cell signaling|immune response	extracellular space|nucleus|soluble fraction				large_intestine(1)	1		all_hematologic(541;4.8e-07)|all_lung(500;0.000434)|Lung NSC(810;0.00161)|Breast(839;0.128)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTAGATGATGAGGTGAGAT	0.512000													6	9					0	0	0.217242	0	0
FOXH1	8928	broad.mit.edu	37	8	145700316	145700316	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:145700316C>A	ENST00000377317.4	-	3	981	c.403G>T	c.(403-405)Ggt>Tgt	p.G135C	FOXH1_ENST00000525197.1_5'UTR	NM_003923.2	NP_003914.1	O75593	FOXH1_HUMAN	forkhead box H1	135					axial mesoderm development|blood vessel development|cell migration involved in gastrulation|embryonic heart tube anterior/posterior pattern formation|floor plate formation|heart looping|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|specification of organ position|transforming growth factor beta receptor signaling pathway	activin responsive factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|R-SMAD binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.76e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CCACGCGCACCTCCGTTCTGC	0.711000													4	30					0.217242	0.220775	0.217242	1	0
PGM3	5238	broad.mit.edu	37	6	83881749	83881749	+	Silent	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:83881749C>T	ENST00000513973.1	-	11	1388	c.1272G>A	c.(1270-1272)ctG>ctA	p.L424L	PGM3_ENST00000512866.1_Silent_p.L424L|PGM3_ENST00000506587.1_Silent_p.L452L|PGM3_ENST00000283977.4_Silent_p.L343L	NM_001199918.1|NM_015599.2	NP_001186847.1|NP_056414.1	O95394	AGM1_HUMAN	phosphoglucomutase 3	424					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	18		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		CTTCAATCACCAGCATGTCAG	0.418000													14	86					0	0	0.435327	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													3	126					0	0	0.115264	0	0
TAOK2	9344	broad.mit.edu	37	16	29989600	29989600	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr16:29989600C>T	ENST00000308893.4	+	4	1275	c.232C>T	c.(232-234)Cgg>Tgg	p.R78W	TAOK2_ENST00000543033.1_Missense_Mutation_p.R78W|TAOK2_ENST00000279394.3_Missense_Mutation_p.R78W	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	78	Protein kinase.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CAAGGAGGTGCGGTTCTTACA	0.577000													6	353					0	0	0.278610	0	0
CEP250	11190	broad.mit.edu	37	20	34091340	34091340	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr20:34091340G>A	ENST00000397527.1	+	30	5863	c.5143G>A	c.(5143-5145)Ggc>Agc	p.G1715S	CEP250_ENST00000342580.4_Missense_Mutation_p.G1659S	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1715	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAAGGGAAGGGCCCAAGTAA	0.572000													21	111					0	0	0.608945	0	0
SLC17A8	246213	broad.mit.edu	37	12	100774639	100774639	+	Missense_Mutation	SNP	A	A	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr12:100774639A>T	ENST00000323346.5	+	2	575	c.262A>T	c.(262-264)Att>Ttt	p.I88F	SLC17A8_ENST00000392989.3_Missense_Mutation_p.I88F	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	88					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						GGGATTCTGCATTTCCTTTGG	0.522000													5	166					0	0	0.184627	0	0
OR6C4	341418	broad.mit.edu	37	12	55945275	55945275	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr12:55945275G>T	ENST00000394256.2	+	1	293	c.265G>T	c.(265-267)Gtt>Ttt	p.V89F	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA	NM_001005494.1	NP_001005494.1	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C, member 4	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	11						AGGAAATAAAGTTATCAGCTT	0.398000													14	266					4.14922e-12	4.98704e-12	0.500413	1	0
MERTK	10461	broad.mit.edu	37	2	112786169	112786169	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:112786169G>A	ENST00000295408.4	+	19	2985	c.2728G>A	c.(2728-2730)Gct>Act	p.A910T	MERTK_ENST00000421804.2_Missense_Mutation_p.A910T|MERTK_ENST00000409780.1_Missense_Mutation_p.A734T			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	910					cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						CACTCCCCGCGCTGCCATCAG	0.562000													28	132					0	0	0.706142	0	0
FAT4	79633	broad.mit.edu	37	4	126411764	126411764	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr4:126411764C>A	ENST00000394329.3	+	17	13800	c.13787C>A	c.(13786-13788)aCt>aAt	p.T4596N	FAT4_ENST00000335110.5_Missense_Mutation_p.T2837N	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4596					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TATGATGAAACTGATATTCCT	0.498000													4	84					0.00909568	0.00963525	0.150653	1	0
ZNF226	7769	broad.mit.edu	37	19	44680231	44680231	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr19:44680231G>A	ENST00000590089.1	+	7	1183	c.816G>A	c.(814-816)caG>caA	p.Q272Q	ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000454662.2_Silent_p.Q272Q|ZNF226_ENST00000337433.5_Silent_p.Q272Q			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				TTCATCAGCAGTTACAATCAG	0.418000													16	99					0	0	0.479597	0	0
ADCY1	107	broad.mit.edu	37	7	45743056	45743056	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:45743056G>A	ENST00000297323.7	+	15	2558	c.2536G>A	c.(2536-2538)Gcc>Acc	p.A846T		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	846					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	GGCCCACGTCGCCCAGCACTT	0.627000													10	36					0	0	0.479597	0	0
UBOX5	22888	broad.mit.edu	37	20	3102446	3102446	+	Nonsense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr20:3102446G>T	ENST00000217173.2	-	3	1310	c.839C>A	c.(838-840)tCa>tAa	p.S280*	UBOX5_ENST00000348031.2_Nonsense_Mutation_p.S280*|UBOX5-AS1_ENST00000446537.1_RNA	NM_001267584.1|NM_014948.3	NP_001254513.1|NP_055763.1	O94941	RNF37_HUMAN	U-box domain containing 5	280	U-box.					nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	20						GACCTTGCCTGAGGGCAGCAG	0.577000													13	59					1.49906e-05	1.67306e-05	0.457914	1	0
FAM124B	79843	broad.mit.edu	37	2	225266290	225266290	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:225266290C>A	ENST00000389874.3	-	1	421	c.196G>T	c.(196-198)Ggg>Tgg	p.G66W	FAM124B_ENST00000409685.3_Missense_Mutation_p.G66W|FAM124B_ENST00000243806.2_Missense_Mutation_p.G66W	NM_024785.2	NP_079061.2	Q9H5Z6	F124B_HUMAN	family with sequence similarity 124B	66							protein binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	16		Renal(207;0.0112)|all_lung(227;0.0126)|Lung NSC(271;0.0161)|all_hematologic(139;0.138)		Epithelial(121;4.4e-10)|all cancers(144;2.02e-07)|Lung(261;0.00766)|LUSC - Lung squamous cell carcinoma(224;0.00825)		ACGGACATCCCTGGAAACCGG	0.567000													3	70					0.004672	0.00503448	0.115264	1	0
THSD7A	221981	broad.mit.edu	37	7	11675781	11675781	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:11675781T>C	ENST00000423059.3	-	2	1249	c.998A>G	c.(997-999)aAg>aGg	p.K333R		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	333						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTTCCCCGTCTTGTTAATGCA	0.378000										HNSCC(18;0.044)			7	248					0	0	0.307466	0	0
GUCY2C	2984	broad.mit.edu	37	12	14804433	14804433	+	Missense_Mutation	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr12:14804433C>G	ENST00000261170.3	-	15	1754	c.1618G>C	c.(1618-1620)Gac>Cac	p.D540H		NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	540	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						TTGTAATAGTCAATCTGAAGC	0.388000													3	129					0	0	0.184627	0	0
NDST4	64579	broad.mit.edu	37	4	115767144	115767144	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr4:115767144G>T	ENST00000264363.2	-	10	2628	c.1950C>A	c.(1948-1950)gaC>gaA	p.D650E		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	650	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TAGGGAAAAAGTCCATATACC	0.343000													16	59					6.72482e-11	7.8561e-11	0.479597	1	0
F13A1	2162	broad.mit.edu	37	6	6152120	6152120	+	Missense_Mutation	SNP	T	T	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:6152120T>G	ENST00000264870.3	-	14	2236	c.1971A>C	c.(1969-1971)ttA>ttC	p.L657F		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	657					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GGGTTTCTTTTAAAGGATTGG	0.468000													25	116					0	0	0.667858	0	0
KCNS2	3788	broad.mit.edu	37	8	99440853	99440853	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:99440853G>A	ENST00000287042.4	+	2	996	c.646G>A	c.(646-648)Gac>Aac	p.D216N	KCNS2_ENST00000521839.1_Missense_Mutation_p.D216N	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	216						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CCAAATCCCTGACAGCCAGGG	0.567000													32	123					0	0	0.750413	0	0
ITPK1	3705	broad.mit.edu	37	14	93483124	93483124	+	Missense_Mutation	SNP	T	T	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr14:93483124T>G	ENST00000267615.6	-	4	316	c.143A>C	c.(142-144)gAg>gCg	p.E48A	ITPK1_ENST00000555495.1_5'UTR|ITPK1_ENST00000354313.3_Missense_Mutation_p.E48A|ITPK1_ENST00000556603.2_Missense_Mutation_p.E48A|ITPK1_ENST00000556954.1_5'UTR			Q13572	ITPK1_HUMAN	inositol-tetrakisphosphate 1-kinase	48					blood coagulation|inositol trisphosphate metabolic process|signal transduction	cytosol	ATP binding|hydrolase activity|inositol tetrakisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5/6-kinase activity|isomerase activity|ligase activity|magnesium ion binding			endometrium(1)|large_intestine(3)|lung(6)|ovary(1)	11		all_cancers(154;0.077)|all_epithelial(191;0.247)		Epithelial(152;0.124)|all cancers(159;0.169)		GCCCTGCTCCTCGATCGGCCG	0.582000													10	54					0	0	0.387290	0	0
ZNF609	23060	broad.mit.edu	37	15	64967791	64967791	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr15:64967791C>A	ENST00000326648.3	+	4	2866	c.2738C>A	c.(2737-2739)cCc>cAc	p.P913H		NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	913						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCTCTGAACCCCAGCAGCCAG	0.507000													19	152					8.10497e-08	9.29469e-08	0.592651	1	0
GTF3C1	2975	broad.mit.edu	37	16	27523215	27523215	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr16:27523215G>A	ENST00000356183.4	-	7	996	c.981C>T	c.(979-981)gaC>gaT	p.D327D	GTF3C1_ENST00000561623.1_Silent_p.D327D	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	327						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GAACCATGACGTCGGTCCCTG	0.542000													4	86					0	0	0.150653	0	0
QSER1	79832	broad.mit.edu	37	11	32953290	32953290	+	Splice_Site	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr11:32953290C>A	ENST00000399302.2	+	4	434	c.97_splice	c.e4-1	p.G33_splice	QSER1_ENST00000527250.1_3'UTR|QSER1_ENST00000527788.1_Splice_Site_p.G33_splice	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	33										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					TCTTCATAGGCATGCATTCCT	0.408000													24	116					2.39556e-15	2.93574e-15	0.639603	1	0
C10orf62	414157	broad.mit.edu	37	10	99349705	99349705	+	Silent	SNP	A	A	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:99349705A>T	ENST00000370640.3	+	1	256	c.51A>T	c.(49-51)ccA>ccT	p.P17P	PI4K2A_ENST00000370649.3_Intron|HOGA1_ENST00000370646.4_Intron|PI4K2A_ENST00000555577.1_Intron|HOGA1_ENST00000370647.4_Intron	NM_001009997.2	NP_001009997.2	Q5T681	CJ062_HUMAN	chromosome 10 open reading frame 62	17							protein binding			endometrium(2)|kidney(1)|lung(1)	4		Colorectal(252;0.162)		Epithelial(162;9.58e-11)|all cancers(201;8.62e-09)		CTGAGTGTCCATCAGACAAGG	0.507000													20	108					0	0	0.624587	0	0
KEL	3792	broad.mit.edu	37	7	142658018	142658018	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:142658018G>A	ENST00000355265.2	-	4	871	c.397C>T	c.(397-399)Ctg>Ttg	p.L133L	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	133					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCCTCACCCAGTATTCTCCGA	0.488000													42	205					0	0	0.870114	0	0
FRZB	2487	broad.mit.edu	37	2	183703339	183703339	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:183703339T>C	ENST00000295113.4	-	4	1204	c.595A>G	c.(595-597)Att>Gtt	p.I199V		NM_001463.3	NP_001454.2	Q92765	SFRP3_HUMAN	frizzled-related protein	199	NTR.				brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			TTAGCCCGAATGACTGGGATA	0.373000													26	122					0	0	0.706142	0	0
CKAP5	9793	broad.mit.edu	37	11	46772146	46772146	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr11:46772146T>C	ENST00000529230.1	-	41	5522	c.5476A>G	c.(5476-5478)Aag>Gag	p.K1826E	CKAP5_ENST00000312055.5_Missense_Mutation_p.K1766E|CKAP5_ENST00000354558.3_Missense_Mutation_p.K1766E|CKAP5_ENST00000415402.1_Missense_Mutation_p.K1833E			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1826					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						ACTTTGGCCTTTGATGATTTT	0.343000													3	60					0	0	0.184627	0	0
IGHV3-72	28410	broad.mit.edu	37	14	107199018	107199018	+	RNA	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr14:107199018T>C	ENST00000433072.2	-	0	350																											TCTCTTGAGATGGTGAATCTG	0.512000													4	146					0	0	0.184627	0	0
PHKA1	5255	broad.mit.edu	37	X	71830970	71830970	+	Nonsense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chrX:71830970C>A	ENST00000373545.3	-	21	2695	c.2257G>T	c.(2257-2259)Gag>Tag	p.E753*	PHKA1_ENST00000541944.1_Nonsense_Mutation_p.E753*|PHKA1_ENST00000373539.3_Nonsense_Mutation_p.E812*|PHKA1_ENST00000373542.4_Nonsense_Mutation_p.E812*|PHKA1_ENST00000339490.3_Nonsense_Mutation_p.E812*			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	812					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CCATACAGCTCGGTAAGAAGC	0.433000													3	70					0.115264	0.119074	0.115264	1	0
FEM1B	10116	broad.mit.edu	37	15	68582628	68582628	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr15:68582628C>A	ENST00000306917.4	+	2	1547	c.932C>A	c.(931-933)cCt>cAt	p.P311H		NM_015322.3	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	311					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						TGTAGAAATCCTCAGGAACTG	0.418000													8	229					0.000157383	0.000172569	0.278610	1	0
MGA	23269	broad.mit.edu	37	15	41988785	41988785	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr15:41988785C>T	ENST00000219905.7	+	3	1758	c.1577C>T	c.(1576-1578)tCa>tTa	p.S526L	MGA_ENST00000545763.1_Missense_Mutation_p.S526L|MGA_ENST00000389936.4_Missense_Mutation_p.S526L|MGA_ENST00000570161.1_Missense_Mutation_p.S526L|MGA_ENST00000566586.1_Missense_Mutation_p.S526L	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	526						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GGCAAGGAATCAGAAAATGGT	0.378000													8	64					0	0	0.307466	0	0
LVRN	206338	broad.mit.edu	37	5	115335578	115335578	+	Missense_Mutation	SNP	T	T	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:115335578T>G	ENST00000357872.4	+	7	1618	c.1494T>G	c.(1492-1494)ttT>ttG	p.F498L	AQPEP_ENST00000395528.2_Missense_Mutation_p.F15L	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		498					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										AGGAACTCTTTGACATATTTA	0.368000													28	148					0	0	0.717897	0	0
SAMD9	54809	broad.mit.edu	37	7	92734736	92734736	+	Silent	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:92734736A>G	ENST00000379958.2	-	3	944	c.675T>C	c.(673-675)gcT>gcC	p.A225A		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	225						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			AATTCATACAAGCTGAAGCAA	0.398000													58	295					0	0	0.870114	0	0
ABCB11	8647	broad.mit.edu	37	2	169874569	169874569	+	Missense_Mutation	SNP	C	C	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:169874569C>A	ENST00000263817.6	-	2	191	c.67G>T	c.(67-69)Gat>Tat	p.D23Y		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	23					bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CATGATTTATCTGACTCAAAA	0.403000													19	163					5.35267e-07	6.08258e-07	0.557998	1	0
ZSCAN31	64288	broad.mit.edu	37	6	28297403	28297403	+	Missense_Mutation	SNP	T	T	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:28297403T>C	ENST00000414429.1	-	6	961	c.58A>G	c.(58-60)Atc>Gtc	p.I20V	ZSCAN31_ENST00000344279.6_Missense_Mutation_p.I20V|ZSCAN31_ENST00000446474.1_Intron|ZSCAN31_ENST00000439158.1_Missense_Mutation_p.I20V|ZSCAN31_ENST00000396838.2_Missense_Mutation_p.I20V					zinc finger and SCAN domain containing 31																		TGGTCCCAGATAGGGTCTTCC	0.463000													32	181					0	0	0.760397	0	0
PPHLN1	51535	broad.mit.edu	37	12	42745776	42745776	+	Missense_Mutation	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr12:42745776T>A	ENST00000395568.2	+	3	246	c.162T>A	c.(160-162)agT>agA	p.S54R	PPHLN1_ENST00000549190.1_Missense_Mutation_p.S72R|PPHLN1_ENST00000358314.7_Missense_Mutation_p.S54R|PPHLN1_ENST00000256678.8_Intron|PPHLN1_ENST00000317560.9_Intron|PPHLN1_ENST00000395580.3_Missense_Mutation_p.S61R|PPHLN1_ENST00000550535.1_3'UTR|PPHLN1_ENST00000337898.6_Intron|PPHLN1_ENST00000449194.2_Missense_Mutation_p.S54R|PPHLN1_ENST00000432191.2_Intron|PPHLN1_ENST00000552761.1_Intron	NM_016488.6	NP_057572.5	Q8NEY8	PPHLN_HUMAN	periphilin 1	54					keratinization	cytoplasm|nucleus				breast(5)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	16	all_cancers(12;0.00049)|Breast(8;0.165)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0875)		GATATTACAGTCATGTTGATT	0.428000													14	90					0	0	0.500413	0	0
AGAP3	116988	broad.mit.edu	37	7	150831516	150831516	+	Missense_Mutation	SNP	G	G	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:150831516G>C	ENST00000397238.2	+	11	1356	c.1356G>C	c.(1354-1356)gaG>gaC	p.E452D	AGAP3_ENST00000463381.1_Missense_Mutation_p.E224D	NM_031946.4	NP_114152.3	Q96P47	AGAP3_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	416	PH.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						ACGGCAAGGAGATTGACCTGC	0.622000													12	65					0	0	0.435327	0	0
RND3	390	broad.mit.edu	37	2	151326539	151326539	+	Missense_Mutation	SNP	A	A	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:151326539A>C	ENST00000375734.2	-	5	946	c.697T>G	c.(697-699)Tta>Gta	p.L233V	RND3_ENST00000409557.1_Missense_Mutation_p.L104V|RND3_ENST00000263895.4_Missense_Mutation_p.L233V	NM_001254738.1	NP_001241667.1	P61587	RND3_HUMAN	Rho family GTPase 3	233					actin cytoskeleton organization|cell adhesion|small GTPase mediated signal transduction	Golgi membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.106)		TCCTTTCGTAAGTCCGTAGCA	0.398000													8	188					0	0	0.278610	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664639	22664639	+	RNA	SNP	G	G	A	rs9306349	by1000genomes	TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr22:22664639G>A	ENST00000426066.1	+	0	820					NR_027293.1																						CCAGCCTTCTGTAACCCAGTA	0.428000													4	87					0	0	0.184627	0	0
LLGL1	3996	broad.mit.edu	37	17	18144992	18144992	+	Silent	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:18144992C>T	ENST00000316843.4	+	18	2826	c.2730C>T	c.(2728-2730)agC>agT	p.S910S		NM_004140.3	NP_004131.3	Q15334	L2GL1_HUMAN	lethal giant larvae homolog 1 (Drosophila)	910					cortical actin cytoskeleton organization|exocytosis|protein complex assembly	cortical actin cytoskeleton	protein kinase binding|structural molecule activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_neural(463;0.228)					AGGACATCAGCGGCATCGCTT	0.657000													5	150					0	0	0.217242	0	0
PTAR1	375743	broad.mit.edu	37	9	72338295	72338295	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr9:72338295G>T	ENST00000377200.5	-	4	659	c.657C>A	c.(655-657)ttC>ttA	p.F219L	PTAR1_ENST00000340434.4_Missense_Mutation_p.F298L			Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat containing 1	298					protein prenylation		protein prenyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)	5						GATCAGTGCTGAATTCAACTT	0.408000													49	279					6.27289e-28	7.84111e-28	0.870114	1	0
RAD54B	25788	broad.mit.edu	37	8	95403999	95403999	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr8:95403999G>A	ENST00000336148.5	-	10	1771	c.1647C>T	c.(1645-1647)tgC>tgT	p.C549C		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding	p.C549C(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			CTCCTGGTCGGCAAAAGACAA	0.398000								Direct reversal of damage;Homologous recombination					5	376					0	0	0.217242	0	0
PAIP1	10605	broad.mit.edu	37	5	43556087	43556087	+	Missense_Mutation	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:43556087G>T	ENST00000306846.3	-	2	512	c.280C>A	c.(280-282)Ctg>Atg	p.L94M	PAIP1_ENST00000338972.4_De_novo_Start_InFrame|PAIP1_ENST00000436644.2_Missense_Mutation_p.L15M|PAIP1_ENST00000514514.1_Missense_Mutation_p.L15M	NM_006451.4|NM_182789.3	NP_006442.2|NP_877590.1	Q9H074	PAIP1_HUMAN	poly(A) binding protein interacting protein 1	94	Pro-rich.				mRNA stabilization|nuclear-transcribed mRNA poly(A) tail shortening|translational initiation	cytosol	protein binding|RNA binding|translation activator activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Lung NSC(6;2.07e-05)					GGAGCTCTCAGGGGCCTCGTT	0.453000													75	324					2.0493e-37	2.5875e-37	0.870114	1	0
TEK	7010	broad.mit.edu	37	9	27213540	27213540	+	Missense_Mutation	SNP	A	A	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr9:27213540A>C	ENST00000380036.4	+	18	3378	c.2936A>C	c.(2935-2937)aAa>aCa	p.K979T	TEK_ENST00000406359.4_Missense_Mutation_p.K936T|TEK_ENST00000519097.1_Missense_Mutation_p.K831T	NM_000459.3	NP_000450.2	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial	979	Protein kinase.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(3)|kidney(1)|lung(2)|ovary(3)|skin(3)	15		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TATGTGGCAAAAATAGCAGAT	0.393000													18	120					0	0	0.557998	0	0
LAMC1	3915	broad.mit.edu	37	1	183093844	183093844	+	Missense_Mutation	SNP	T	T	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:183093844T>A	ENST00000258341.4	+	14	2737	c.2480T>A	c.(2479-2481)cTg>cAg	p.L827Q		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	827	Laminin EGF-like 7.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTTGCCGCCTGTGCCAGTGC	0.507000													5	76					0	0	0.278610	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	141					0	0	0.150653	0	0
SLC25A39	51629	broad.mit.edu	37	17	42397438	42397438	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:42397438C>T	ENST00000225308.8	-	12	1161	c.987G>A	c.(985-987)atG>atA	p.M329I	SLC25A39_ENST00000377095.5_Missense_Mutation_p.M337I|SLC25A39_ENST00000586016.1_Missense_Mutation_p.M205I|SLC25A39_ENST00000590194.1_Missense_Mutation_p.M329I|SLC25A39_ENST00000537904.2_Missense_Mutation_p.M314I	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	337					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		AGGTGCTGATCATGATGGCAC	0.617000													30	118					0	0	0.779181	0	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr11:115080343G>T	ENST00000537058.1	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000542447.2_Intron|CADM1_ENST00000452722.2_Silent_p.T343T|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000331581.6_Silent_p.T343T|CADM1_ENST00000537140.1_Intron			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	343				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													5	90					0.014758	0.0155021	0.184627	1	0
SLC16A9	220963	broad.mit.edu	37	10	61413932	61413932	+	Silent	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:61413932C>T	ENST00000395348.3	-	5	1488	c.852G>A	c.(850-852)aaG>aaA	p.K284K	SLC16A9_ENST00000395347.1_Silent_p.K284K	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	284					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						GCCACTTCCTCTTGGCAAGCT	0.373000													45	279					0	0	0.870114	0	0
C5orf55	116349	broad.mit.edu	37	5	442720	442720	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:442720C>T	ENST00000408966.2	-	1	538	c.218G>A	c.(217-219)cGc>cAc	p.R73H		NM_138464.2	NP_612473.1	Q8N2X6	CE055_HUMAN	chromosome 5 open reading frame 55	73						extracellular region				large_intestine(1)|lung(2)	3						CCAATGACTGCGCTCCTGGAG	0.602000													32	179					0	0	0.760397	0	0
ACRC	93953	broad.mit.edu	37	X	70823810	70823810	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chrX:70823810G>A	ENST00000373695.1	+	7	1220	c.683G>A	c.(682-684)aGc>aAc	p.S228N	ACRC_ENST00000373696.3_Missense_Mutation_p.S228N			Q96QF7	ACRC_HUMAN	acidic repeat containing	228	Asp/Ser-rich.					nucleus				autonomic_ganglia(1)|breast(1)|endometrium(15)|kidney(4)|large_intestine(4)|lung(20)|ovary(5)|prostate(1)|skin(2)|stomach(1)	54	Renal(35;0.156)					CCCGACGACAGCAGTGATGAT	0.517000													6	303					0	0	0.217242	0	0
CHD1	1105	broad.mit.edu	37	5	98217770	98217770	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:98217770C>T	ENST00000284049.3	-	19	2925	c.2776G>A	c.(2776-2778)Gcg>Acg	p.A926T		NM_001270.2	NP_001261.2	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	926	Helicase C-terminal.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(2)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	49		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	TTCTTTTTCGCCCTTTCAAGA	0.363000													30	75					0	0	0.706142	0	0
USP1	7398	broad.mit.edu	37	1	62911028	62911028	+	Missense_Mutation	SNP	G	G	C			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:62911028G>C	ENST00000339950.4	+	6	1992	c.1177G>C	c.(1177-1179)Ggt>Cgt	p.G393R	USP1_ENST00000371146.1_Missense_Mutation_p.G393R	NM_003368.4	NP_003359.3	O94782	UBP1_HUMAN	ubiquitin specific peptidase 1	393					DNA repair|monoubiquitinated protein deubiquitination|regulation of DNA repair|response to UV|ubiquitin-dependent protein catabolic process	nucleoplasm	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	19		all_neural(321;0.0281)		BRCA - Breast invasive adenocarcinoma(111;8.01e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00245)|OV - Ovarian serous cystadenocarcinoma(397;0.0535)		CACAACTAATGGTTGTGGACT	0.343000													16	82					0	0	0.500413	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													3	15					0	0	0.115264	0	0
PNLIP	5406	broad.mit.edu	37	10	118327269	118327269	+	Missense_Mutation	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:118327269A>G	ENST00000369221.2	+	13	1385	c.1357A>G	c.(1357-1359)Acc>Gcc	p.T453A		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	453	PLAT.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TAGTCCAGAAACCGTCAGGGA	0.438000													7	131					0	0	0.278610	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661478	22661478	+	RNA	SNP	T	T	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr22:22661478T>G	ENST00000426066.1	+	0	368					NR_027293.1																						CAGATGCGTCTGAAGAAACAT	0.488000													5	79					0	0	0.248553	0	0
INSRR	3645	broad.mit.edu	37	1	156823587	156823587	+	Silent	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:156823587C>T	ENST00000368195.3	-	2	990	c.594G>A	c.(592-594)ggG>ggA	p.G198G	NTRK1_ENST00000392302.2_Intron	NM_014215.2	NP_055030.1	P14616	INSRR_HUMAN	insulin receptor-related receptor	198					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(7)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	42	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					AGTCAGTGTGCCCGCTGAAGG	0.612000													3	83					0	0	0.150653	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445423	10445423	+	Missense_Mutation	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr4:10445423G>A	ENST00000326756.3	-	3	2968	c.2530C>T	c.(2530-2532)Cgg>Tgg	p.R844W		NM_053042.2	NP_444270.2	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	844					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	42						AGTTTAGGCCGCAGAGGTGTC	0.463000													4	143					0	0	0.150653	0	0
UBR4	23352	broad.mit.edu	37	1	19407942	19407942	+	Missense_Mutation	SNP	A	A	G			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr1:19407942A>G	ENST00000375267.2	-	103	15137	c.15134T>C	c.(15133-15135)aTc>aCc	p.I5045T	UBR4_ENST00000375224.1_Missense_Mutation_p.I752T|UBR4_ENST00000375254.3_Missense_Mutation_p.I5045T|UBR4_ENST00000375217.2_Missense_Mutation_p.I5038T|UBR4_ENST00000375226.2_Missense_Mutation_p.I5021T|UBR4_ENST00000375225.3_Missense_Mutation_p.I120T|UBR4_ENST00000543981.1_Missense_Mutation_p.I709T|UBR4_ENST00000429347.2_Missense_Mutation_p.I568T			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5045					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGGGGGCAGGATGTGAAGGGC	0.592000													11	255					0	0	0.361761	0	0
FBXW10	10517	broad.mit.edu	37	17	18675803	18675803	+	Silent	SNP	G	G	A			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:18675803G>A	ENST00000308799.4	+	11	2391	c.2172G>A	c.(2170-2172)acG>acA	p.T724T	FBXW10_ENST00000395665.4_Silent_p.T695T|FBXW10_ENST00000301938.4_Silent_p.T642T|FBXW10_ENST00000395667.1_Silent_p.T695T|FBXW10_ENST00000573605.1_3'UTR			Q5XX13	FBW10_HUMAN	F-box and WD repeat domain containing 10	695										NS(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42						Tggaaaaaacgaaacaaaaga	0.408000													57	242					0	0	0.870114	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													3	124					0	0	0.115264	0	0
CELSR3	1951	broad.mit.edu	37	3	48691328	48691328	+	Missense_Mutation	SNP	C	C	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:48691328C>T	ENST00000544264.1	-	8	5541	c.5261G>A	c.(5260-5262)gGc>gAc	p.G1754D	CELSR3_ENST00000164024.4_Missense_Mutation_p.G1754D			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1754	EGF-like 4; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACAGTCTTTGCCGCCGAAGCC	0.602000													3	78					0	0	0.115264	0	0
LOC100506457	100506457	broad.mit.edu	37	2	12293343	12293351	+	RNA	DEL	TTCCTTCCC	TTCCTTCCC	-	rs112549370		TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:12293343_12293351delTTCCTTCCC	ENST00000412294.1	+	0	197																											cttcattcctttccttcccttccttccct	0.426													4	6	---	---	---	---					
PASK	23178	broad.mit.edu	37	2	242079401	242079401	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr2:242079401delG	ENST00000403638.3	-	4	590	c.499delC	c.(499-501)tcfs	p.L167fs	PASK_ENST00000544142.1_Intron|PASK_ENST00000539818.1_Intron|PASK_ENST00000405260.1_Frame_Shift_Del_p.L167fs|PASK_ENST00000234040.4_Frame_Shift_Del_p.L167fs|PASK_ENST00000358649.4_Frame_Shift_Del_p.L167fs	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	167	PAS 1.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		AACTGCGTGAGCTTCTGGCCA	0.582													18	43	---	---	---	---					
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:5248941delT	ENST00000256497.4	+	7	1454	c.1321delT	c.(1321-1323)ttfs	p.F442fs	EDEM1_ENST00000445686.1_Frame_Shift_Del_p.F247fs	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	442					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463													7	187	---	---	---	---					
VHL	7428	broad.mit.edu	37	3	10188252	10188252	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr3:10188252delA	ENST00000256474.2	+	2	1235	c.395delA	c.(394-396)cafs	p.Q132fs	VHL_ENST00000477538.1_3'UTR|VHL_ENST00000345392.2_Intron	NM_000551.3	NP_000542.1	P40337	VHL_HUMAN	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	132	Involved in binding to CCT complex.				anti-apoptosis|cell morphogenesis|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell differentiation|positive regulation of transcription, DNA-dependent|protein stabilization|protein ubiquitination|proteolysis	cytosol|endoplasmic reticulum|membrane|mitochondrion|nucleus	protein binding|transcription factor binding	p.T133fs*26(4)|p.N131fs*27(2)|p.Q132fs*2(1)|p.N131fs*10(1)|p.N131*(1)|p.N131fs*7(1)		adrenal_gland(25)|autonomic_ganglia(3)|central_nervous_system(2)|endometrium(6)|kidney(1662)|large_intestine(14)|lung(6)|pancreas(18)|paratesticular_tissues(1)|pleura(1)|skin(1)|soft_tissue(24)|thyroid(3)|upper_aerodigestive_tract(3)	1769				Kidney(1;0.000404)|KIRC - Kidney renal clear cell carcinoma(1;0.000569)		CTGGTTAACCAAACTGAATTA	0.453		1	"""D, Mis, N, F, S"""		"""renal, hemangioma, pheochromocytoma"""	"""renal, hemangioma, pheochromocytoma"""			von Hippel-Lindau disease;Pheochromocytoma (Adrenal), Familial;Chuvash Polycythemia				51	298	---	---	---	---					
LOC152578	152578	broad.mit.edu	37	4	53661752	53661765	+	RNA	DEL	AAGAAAGAGAGAGA	AAGAAAGAGAGAGA	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr4:53661752_53661765delAAGAAAGAGAGAGA	ENST00000514957.1	+	0	321					NR_040106.1																						ggaaggaaggaagaaagagagagaaagaaagaga	0.407													4	2	---	---	---	---					
NDST4	64579	broad.mit.edu	37	4	115767136	115767136	+	Frame_Shift_Del	DEL	G	G	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr4:115767136delG	ENST00000264363.2	-	10	2636	c.1958delC	c.(1957-1959)ctfs	p.P653fs		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	653	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GGATGGTGTAGGGAAAAAGTC	0.358													17	72	---	---	---	---					
UIMC1	51720	broad.mit.edu	37	5	176395660	176395663	+	Frame_Shift_Del	DEL	CCCT	CCCT	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr5:176395660_176395663delCCCT	ENST00000377219.2	-	6	1259_1262	c.1093_1096delAGGG	c.(1093-1098)cafs	p.RA365fs	UIMC1_ENST00000377227.4_Frame_Shift_Del_p.RA365fs|UIMC1_ENST00000503273.1_5'UTR|UIMC1_ENST00000511320.1_Frame_Shift_Del_p.RA365fs|UIMC1_ENST00000506128.1_Intron	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	365	AIR.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGTCAGATGCCCTAGACTCCTGC	0.441													32	357	---	---	---	---					
SAMD3	154075	broad.mit.edu	37	6	130465915	130465915	+	Frame_Shift_Del	DEL	T	T	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:130465915delT	ENST00000368134.2	-	14	1921	c.1313delA	c.(1312-1314)acfs	p.N438fs	SAMD3_ENST00000457563.2_Frame_Shift_Del_p.N462fs|SAMD3_ENST00000437477.2_Frame_Shift_Del_p.N438fs|SAMD3_ENST00000439090.2_Frame_Shift_Del_p.N438fs	NM_001258275.1	NP_001245204.1	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3	438										breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GTTGAAAGGGTTTTTAACTTC	0.403													26	98	---	---	---	---					
TARID	100507308	broad.mit.edu	37	6	134013764	134013765	+	RNA	DEL	AC	AC	-	rs34919164		TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr6:134013764_134013765delAC	ENST00000607033.1	-	0	623				RP3-323P13.2_ENST00000607573.1_RNA|RP3-323P13.2_ENST00000606544.1_RNA|RP3-323P13.2_ENST00000606292.1_RNA																							aaaaaaGCAAacacacacacac	0.475													3	6	---	---	---	---					
CCDC132	55610	broad.mit.edu	37	7	92940514	92940527	+	Frame_Shift_Del	DEL	AGATTACAGTCTAA	AGATTACAGTCTAA	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:92940514_92940527delAGATTACAGTCTAA	ENST00000544910.1	+	21	1915_1928	c.1695_1708delAGATTACAGTCTAA	c.(1693-1710)tcatfs	p.SDYSLN565fs	CCDC132_ENST00000317751.6_Frame_Shift_Del_p.SDYSLN326fs|CCDC132_ENST00000541136.1_Frame_Shift_Del_p.SDYSLN406fs|CCDC132_ENST00000305866.5_Frame_Shift_Del_p.SDYSLN595fs|CCDC132_ENST00000535481.1_Frame_Shift_Del_p.SDYSLN315fs	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	595										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			GGAAGAAATCAGATTACAGTCTAAATAAAGTGAA	0.304													24	373	---	---	---	---					
TRBV29-1	28558	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													8	10	---	---	---	---					
LOC403323	403323	broad.mit.edu	37	9	66545695	66545695	+	RNA	DEL	A	A	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr9:66545695delA	ENST00000445604.2	-	0	669																											CTGTAAGAGGAAAAAAAAACA	0.373													4	7	---	---	---	---					
ITIH2	3698	broad.mit.edu	37	10	7786219	7786220	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr10:7786219_7786220delAC	ENST00000358415.4	+	18	2550_2551	c.2384_2385delAC	c.(2383-2385)gfs	p.D795fs	ITIH2_ENST00000379587.4_Frame_Shift_Del_p.D784fs	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	795					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TCCTGGTCCGACACGGCTCAAG	0.460													25	171	---	---	---	---					
NUDT22	84304	broad.mit.edu	37	11	63997567	63997567	+	RNA	DEL	A	A	-	rs11364788		TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr11:63997567delA	ENST00000534988.1	-	0	99																											GTGACTTGGGAAAAAAAAAAA	0.498													4	7	---	---	---	---					
DIAPH3	81624	broad.mit.edu	37	13	60582733	60582734	+	Frame_Shift_Ins	INS	-	-	T			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr13:60582733_60582734insT	ENST00000400324.4	-	9	1178_1179	c.958_959insA	c.(958-960)tgafs	p.*320fs	DIAPH3_ENST00000465066.1_5'UTR|DIAPH3_ENST00000267215.4_Frame_Shift_Ins_p.*320fs|DIAPH3_ENST00000400319.1_Frame_Shift_Ins_p.*250fs|DIAPH3_ENST00000400320.1_Frame_Shift_Ins_p.*274fs|DIAPH3_ENST00000400330.1_Frame_Shift_Ins_p.*320fs|DIAPH3_ENST00000377908.2_Frame_Shift_Ins_p.*309fs	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	320	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AAATCTGTCAATTTTTTTTTCT	0.322													8	280	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs|CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													9	116	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60347260	60347260	+	RNA	DEL	T	T	-	rs71816198		TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr17:60347260delT	ENST00000581291.1	-	0	581																				breast(2)|kidney(1)|lung(2)	5						CTCTGAATGATTTTTTTTTTT	0.448													5	8	---	---	---	---					
SCAF4	57466	broad.mit.edu	37	21	33064127	33064132	+	Splice_Site	DEL	TACCTT	TACCTT	-			TCGA-B8-5162-01A-01D-1421-08	TCGA-B8-5162-10A-01D-1421-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	451e7b1a-dbc5-4360-81fe-861b1d825ed4	26b27e79-d6a3-42f4-8c2b-a93035b1a669	g.chr21:33064127_33064132delTACCTT	ENST00000286835.7	-	14	2108_2111	c.1728_splice	c.e14+1	p.576_splice	SCAF4_ENST00000399804.1_Splice_Site_p.576_splice|SCAF4_ENST00000434667.3_Splice_Site_p.561_splice	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	576	RRM.					nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						TGTAAGACTGTACCTTTATGGATTTC	0.364													22	166	---	---	---	---