Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLXNA4	91584	broad.mit.edu	37	7	131844259	131844259	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr7:131844259G>A	ENST00000359827.3	-	25	5595	c.4633C>T	c.(4633-4635)Cgg>Tgg	p.R1545W	PLXNA4_ENST00000321063.4_Missense_Mutation_p.R1545W			Q9HCM2	PLXA4_HUMAN	plexin A4	1545						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCTTTGGGCCGGTGGGAGCAA	0.557000													4	200					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	41961691	41961691	+	Missense_Mutation	SNP	A	A	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr15:41961691A>C	ENST00000219905.7	+	2	780	c.599A>C	c.(598-600)tAc>tCc	p.Y200S	MGA_ENST00000568630.1_Intron|MGA_ENST00000570161.1_Missense_Mutation_p.Y200S|MGA_ENST00000389936.4_Missense_Mutation_p.Y200S|MGA_ENST00000566586.1_Missense_Mutation_p.Y200S|MGA_ENST00000545763.1_Missense_Mutation_p.Y200S	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	200						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		ATGCATCGTTACCTGCCGAGG	0.438000													5	70					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791715	42791715	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr19:42791715C>T	ENST00000572681.2	+	6	3396	c.3328C>T	c.(3328-3330)Cgg>Tgg	p.R1110W	CIC_ENST00000160740.3_Missense_Mutation_p.R201W|CIC_ENST00000575354.2_Missense_Mutation_p.R201W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	201	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.R201W(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGACCACATCCGGCGGCCCAT	0.622000			"""Mis, F, S"""		oligodendroglioma								17	8					0	0	1	0	0
SEC16A	9919	broad.mit.edu	37	9	139370473	139370473	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr9:139370473C>G	ENST00000313050.7	-	1	1668	c.1595G>C	c.(1594-1596)aGg>aCg	p.R532T	SEC16A_ENST00000290037.6_Missense_Mutation_p.R354T|SEC16A_ENST00000431893.2_Missense_Mutation_p.R354T|SEC16A_ENST00000371706.3_Missense_Mutation_p.R354T	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	354					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GCCTGAGAGCCTTCCGTGGCT	0.547000													16	17					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212765	26212765	+	Silent	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chrX:26212765C>T	ENST00000379034.1	+	2	951	c.802C>T	c.(802-804)Cta>Tta	p.L268L		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	268	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						TGTCAGCAAGCTAGGCCTCCC	0.522000													57	65					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26951259	26951259	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:26951259T>C	ENST00000528896.2	-	25	4818	c.4744A>G	c.(4744-4746)Aac>Gac	p.N1582D	KIAA0100_ENST00000544884.1_Missense_Mutation_p.N1439D|KIAA0100_ENST00000389003.3_Missense_Mutation_p.N1439D	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1582						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					ACCTGACAGTTGACCAATTCA	0.448000													14	98					0	0	1	0	0
ELK1	2002	broad.mit.edu	37	X	47497377	47497377	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chrX:47497377G>A	ENST00000247161.3	-	4	958	c.859C>T	c.(859-861)Ccc>Tcc	p.P287S	ELK1_ENST00000376983.3_Missense_Mutation_p.P287S|ELK1_ENST00000343894.4_Intron|ELK1_ENST00000592066.1_Missense_Mutation_p.P233S	NM_005229.4	NP_005220.2	P19419	ELK1_HUMAN	ELK1, member of ETS oncogene family	287					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	10						ACAACCGCGGGCAGCCGGGCT	0.667000													8	7					0	0	1	0	0
DNAJC8	22826	broad.mit.edu	37	1	28527866	28527866	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr1:28527866G>A	ENST00000263697.4	-	9	681	c.655C>T	c.(655-657)Cgt>Tgt	p.R219C	DNAJC8_ENST00000489277.1_5'UTR	NM_014280.2	NP_055095.2	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	219					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		CTGTCCACACGACCATCTCGA	0.488000													4	77					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62196762	62196762	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr20:62196762G>A	ENST00000467148.1	-	8	3482	c.3413C>T	c.(3412-3414)aCc>aTc	p.T1138I	HELZ2_ENST00000427522.2_Missense_Mutation_p.T569I	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CCGCTCGAAGGTCTCTGGCAC	0.701000													11	12					0	0	1	0	0
SDHAP3	0	broad.mit.edu	37	5	1593264	1593264	+	RNA	SNP	C	C	T	rs111700178	by1000genomes	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr5:1593264C>T	ENST00000436493.2	-	0	361																											AGGGCACATGCCTGACCAAAG	0.557000													4	38					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56566784	56566784	+	Silent	SNP	A	A	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr12:56566784A>C	ENST00000394023.3	-	18	1785	c.1680T>G	c.(1678-1680)gcT>gcG	p.A560A	SMARCC2_ENST00000347471.4_Silent_p.A560A|SMARCC2_ENST00000550164.1_Silent_p.A560A|SMARCC2_ENST00000267064.4_Intron|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	550					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCTTTCGCCCAGCCTTGGTAT	0.622000													13	20					0	0	1	0	0
EZH1	2145	broad.mit.edu	37	17	40870506	40870506	+	Silent	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:40870506G>A	ENST00000428826.2	-	9	1018	c.897C>T	c.(895-897)tgC>tgT	p.C299C	EZH1_ENST00000435174.1_Silent_p.C160C|EZH1_ENST00000415827.2_Silent_p.C290C|EZH1_ENST00000592743.1_Silent_p.C299C|EZH1_ENST00000590078.1_Silent_p.C229C|EZH1_ENST00000585893.1_Silent_p.C259C			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	299					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		AGCAGCGCCGGCAAAAAAGTG	0.537000													3	40					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43237188	43237188	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr19:43237188T>C	ENST00000327495.5	-	3	641	c.457A>G	c.(457-459)Agc>Ggc	p.S153G	PSG3_ENST00000595140.1_Missense_Mutation_p.S153G	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	153	Ig-like C2-type 1.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				AAGTTGCTGCTGGAGATGGAG	0.517000													96	26					0	0	1	0	0
MAMDC4	158056	broad.mit.edu	37	9	139749232	139749232	+	Missense_Mutation	SNP	T	T	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr9:139749232T>A	ENST00000445819.1	+	9	1003	c.953T>A	c.(952-954)gTg>gAg	p.V318E	MAMDC4_ENST00000485732.1_Intron|MAMDC4_ENST00000317446.2_Missense_Mutation_p.V318E			Q6UXC1	AEGP_HUMAN	MAM domain containing 4	318	MAM 2.				protein transport	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	19	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.52e-05)|Epithelial(140;0.000171)		CTGGTCTCCGTGGCCGAGCCT	0.692000													3	58					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558761	113558761	+	Silent	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr7:113558761G>A	ENST00000284601.3	-	1	359	c.291C>T	c.(289-291)gaC>gaT	p.D97D		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	97					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGTGGAAAATGTCCGTCCCTA	0.383000													36	48					0	0	1	0	0
SPDYE4	388333	broad.mit.edu	37	17	8659725	8659725	+	Missense_Mutation	SNP	A	A	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:8659725A>C	ENST00000328794.6	-	3	546	c.370T>G	c.(370-372)Tgg>Ggg	p.W124G		NM_001128076.1	NP_001121548.1	A6NLX3	SPDE4_HUMAN	speedy/RINGO cell cycle regulator family member E4	124										breast(1)|endometrium(2)|kidney(1)	4						TCTTTGTCCCAGGCCAGGAAT	0.537000													20	166					0	0	1	0	0
SLFN12	55106	broad.mit.edu	37	17	33750022	33750022	+	Missense_Mutation	SNP	G	G	A	rs143225670		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:33750022G>A	ENST00000394562.1	-	4	549	c.26C>T	c.(25-27)aCg>aTg	p.T9M	SLFN12_ENST00000304905.5_Missense_Mutation_p.T9M|SLFN12_ENST00000452764.3_Missense_Mutation_p.T9M			Q8IYM2	SLN12_HUMAN	schlafen family member 12	9							ATP binding			breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GGCATAATTCGTTTCCAAATC	0.388000													56	76					0	0	1	0	0
MYH1	4619	broad.mit.edu	37	17	10419889	10419889	+	Missense_Mutation	SNP	C	C	T	rs61730792	byFrequency	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:10419889C>T	ENST00000226207.5	-	3	165	c.71G>A	c.(70-72)cGa>cAa	p.R24Q	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	24	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity	p.R24Q(1)		NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						GGCTTCAATTCGCTCCCTTTC	0.507000													59	54					0	0	1	0	0
CPO	130749	broad.mit.edu	37	2	207825632	207825632	+	Silent	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr2:207825632G>A	ENST00000272852.3	+	6	586	c.540G>A	c.(538-540)acG>acA	p.T180T		NM_173077.2	NP_775100.1	Q8IVL8	CBPO_HUMAN	carboxypeptidase O	180					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	14				LUSC - Lung squamous cell carcinoma(261;0.0744)|Epithelial(149;0.0807)|Lung(261;0.142)		GTTTTGGGACGGATCTCAATC	0.388000													4	150					0	0	1	0	0
CRX	1406	broad.mit.edu	37	19	48342774	48342774	+	Silent	SNP	A	A	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr19:48342774A>T	ENST00000221996.7	+	4	656	c.450A>T	c.(448-450)tcA>tcT	p.S150S	TPRX2P_ENST00000535362.1_Intron|CRX_ENST00000539067.1_Silent_p.S150S	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	150					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		CCGGCCCCTCAGGCTCCCCAA	0.667000													3	37					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18844766	18844766	+	RNA	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr22:18844766G>A	ENST00000412938.1	+	0	3016																											CAGCCTCTGAGGGCAGCAGTG	0.557000													3	13					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414343	20414343	+	Silent	SNP	A	A	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr9:20414343A>G	ENST00000380338.4	-	5	787	c.501T>C	c.(499-501)agT>agC	p.S167S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S164S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	167	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S167S(19)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctactgctgctgc	0.532000			T	MLL	ALL								8	84					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68273386	68273386	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr14:68273386G>A	ENST00000347230.4	-	6	1031	c.893C>T	c.(892-894)cCg>cTg	p.P298L	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.P298L	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	298					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TAGATGATCCGGTGAGACTGA	0.478000													13	3					0	0	1	0	0
APBA2	321	broad.mit.edu	37	15	29346469	29346469	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr15:29346469C>G	ENST00000558402.1	+	5	981	c.382C>G	c.(382-384)Cct>Gct	p.P128A	APBA2_ENST00000411764.1_Missense_Mutation_p.P128A|APBA2_ENST00000561069.1_Missense_Mutation_p.P128A|APBA2_ENST00000558330.1_Missense_Mutation_p.P128A|APBA2_ENST00000558259.1_Missense_Mutation_p.P128A			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	128					nervous system development|protein transport		protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		CAGTGCACACCCTGTGGACAC	0.657000													30	38					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000230354.6_Silent_p.Q76Q|TBP_ENST00000540980.1_Silent_p.Q56Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													4	35					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								31	43					0	0	1	0	0
ELK1	2002	broad.mit.edu	37	X	47497378	47497378	+	Silent	SNP	C	C	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chrX:47497378C>G	ENST00000247161.3	-	4	957	c.858G>C	c.(856-858)ctG>ctC	p.L286L	ELK1_ENST00000376983.3_Silent_p.L286L|ELK1_ENST00000343894.4_Intron|ELK1_ENST00000592066.1_Silent_p.L232L	NM_005229.4	NP_005220.2	P19419	ELK1_HUMAN	ELK1, member of ETS oncogene family	286					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	10						CAACCGCGGGCAGCCGGGCTG	0.672000													8	8					0	0	1	0	0
OR4B1	119765	broad.mit.edu	37	11	48239206	48239206	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr11:48239206C>T	ENST00000309562.2	+	1	863	c.845C>T	c.(844-846)cCc>cTc	p.P282L		NM_001005470.1	NP_001005470.1	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B, member 1	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						ATGCTGAACCCCATCATTTAC	0.458000													26	46					0	0	1	0	0
XXbac-BPG308J9.3	0	broad.mit.edu	37	6	29231829	29231829	+	RNA	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr6:29231829G>A	ENST00000441381.1	+	0	300																											AGGAGCATAAGCCAACCAAAG	0.363000													4	65					0	0	1	0	0
AL928742.12	0	broad.mit.edu	37	14	106066370	106066370	+	RNA	SNP	T	T	C	rs1134593		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr14:106066370T>C	ENST00000412518.1	-	0	6				IGHE_ENST00000576077.1_RNA|IGHE_ENST00000577108.1_RNA																							CACAGCTGGATGGAGCCCTGG	0.602000													5	83					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	109001439	109001439	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr8:109001439C>T	ENST00000276659.5	-	3	748	c.128G>A	c.(127-129)tGt>tAt	p.C43Y	RSPO2_ENST00000517939.1_5'UTR|RSPO2_ENST00000517781.1_Intron|RSPO2_ENST00000378439.2_Intron	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	43					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			ACAAGACAAACAACCCTTGCA	0.383000													14	21					0	0	1	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47246206	47246206	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:47246206C>T	ENST00000300404.2	+	10	1498	c.1439C>T	c.(1438-1440)aCg>aTg	p.T480M	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.T394M|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.T420M	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	480					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CTGGCCCACACGGAGCGACTC	0.597000													10	11					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624181	154624181	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr4:154624181G>T	ENST00000260010.6	+	1	1530	c.122G>T	c.(121-123)gGa>gTa	p.G41V		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	41					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				GGCAGCTCAGGATCTTTAAAC	0.502000													26	44					2.44723e-14	2.69195e-14	1	1	0
FRMPD3	84443	broad.mit.edu	37	X	106840784	106840784	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chrX:106840784C>T	ENST00000276185.4	+	15	1774	c.1774C>T	c.(1774-1776)Cga>Tga	p.R592*				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	592						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						GACCAGGCCCCGAACCAAGTC	0.527000													6	92					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248309019	248309019	+	Silent	SNP	T	T	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr1:248309019T>C	ENST00000366476.1	+	1	570	c.570T>C	c.(568-570)aaT>aaC	p.N190N		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TCTCATGCAATGACACATCAA	0.413000													12	300					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952072	178952072	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr3:178952072A>G	ENST00000263967.3	+	21	3284	c.3127A>G	c.(3127-3129)Atg>Gtg	p.M1043V		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043V(22)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGAAACAAATGAATGATGC	0.368000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	28					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72316850	72316850	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr12:72316850G>T	ENST00000550746.1	+	18	2006	c.1942G>T	c.(1942-1944)Gtt>Ttt	p.V648F	TBC1D15_ENST00000393309.3_Missense_Mutation_p.V402F|TBC1D15_ENST00000319106.8_Missense_Mutation_p.V639F|TBC1D15_ENST00000485960.2_Missense_Mutation_p.V631F	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	648							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGACGAAAATGTTGTCATGAC	0.458000													33	52					5.60225e-13	5.96368e-13	1	1	0
UBBP4	0	broad.mit.edu	37	17	21730916	21730916	+	Missense_Mutation	SNP	G	G	T	rs111245273	by1000genomes	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:21730916G>T	ENST00000584755.1	+	2	615	c.218G>T	c.(217-219)cGg>cTg	p.R73L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R73L|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron														p.R73L(24)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCGGAGAGGTGGT	0.552000													4	64					2.56e-06	2.6819e-06	1	1	0
UQCC	0	broad.mit.edu	37	20	33981930	33981930	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr20:33981930C>T	ENST00000397554.1	-	2	104	c.94G>A	c.(94-96)Gga>Aga	p.G32R	UQCC_ENST00000374377.5_Missense_Mutation_p.R12K|UQCC_ENST00000374380.2_Missense_Mutation_p.G32R|UQCC_ENST00000374384.2_Missense_Mutation_p.G32R|UQCC_ENST00000359226.2_Missense_Mutation_p.G32R|UQCC_ENST00000349714.5_Missense_Mutation_p.G32R|UQCC_ENST00000542501.1_Missense_Mutation_p.G32R|UQCC_ENST00000540457.1_Intron|UQCC_ENST00000407996.2_Missense_Mutation_p.G32R|UQCC_ENST00000374385.5_Missense_Mutation_p.G32R|UQCC_ENST00000491125.1_5'UTR|UQCC_ENST00000397556.3_5'UTR			Q9NVA1	UQCC_HUMAN		32						cytoplasmic membrane-bounded vesicle				breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(1)|urinary_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TCCCCCTGTCCTTGGGTAGGA	0.423000													34	51					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199020	118199020	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr12:118199020G>A	ENST00000425217.1	-	4	749	c.695C>T	c.(694-696)cCg>cTg	p.P232L	KSR2_ENST00000339824.5_Missense_Mutation_p.P261L	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	261	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGCGCGGCGGGGTGCGGAC	0.751000													6	116					0	0	1	0	0
SUCLA2	8803	broad.mit.edu	37	13	48528668	48528668	+	Missense_Mutation	SNP	T	T	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr13:48528668T>A	ENST00000378654.3	-	7	883	c.827A>T	c.(826-828)aAt>aTt	p.N276I	SUCLA2_ENST00000544100.1_Missense_Mutation_p.N142I|SUCLA2_ENST00000543413.1_Missense_Mutation_p.N218I|SUCLA2_ENST00000534875.1_Missense_Mutation_p.N218I	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	276	ATP-grasp.				succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	AGAGTCAAAATTGATCTTTGC	0.358000													27	32					0	0	1	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562493	75562493	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr15:75562493C>A	ENST00000300576.5	+	18	2035	c.2035C>A	c.(2035-2037)Ccg>Acg	p.P679T		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	679										ovary(1)	1						TGACAACCCCCCGGTACAGCA	0.602000													6	108					0.00198382	0.00198382	1	1	0
TRMT10A	93587	broad.mit.edu	37	4	100479223	100479223	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr4:100479223G>A	ENST00000273962.3	-	3	643	c.331C>T	c.(331-333)Cac>Tac	p.H111Y	TRMT10A_ENST00000394876.2_Missense_Mutation_p.H111Y|TRMT10A_ENST00000394877.3_Missense_Mutation_p.H111Y	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		ACCATCAAGTGATCAAAACTA	0.338000													27	20					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53876605	53876605	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr12:53876605C>T	ENST00000267079.2	-	12	2108	c.1883G>A	c.(1882-1884)gGa>gAa	p.G628E	MAP3K12_ENST00000547035.1_Missense_Mutation_p.G661E|MAP3K12_ENST00000547488.1_Missense_Mutation_p.G661E	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	628			G -> R (in dbSNP:rs34366500).		histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						ATCCCCAGCTCCGCCTGTGGC	0.677000													32	26					0	0	1	0	0
OR2M7	391196	broad.mit.edu	37	1	248487301	248487301	+	Silent	SNP	A	A	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr1:248487301A>G	ENST00000317965.2	-	1	598	c.570T>C	c.(568-570)aaT>aaC	p.N190N		NM_001004691.1	NP_001004691.1	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M, member 7	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(6)|large_intestine(3)|lung(29)|skin(3)	42	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGATGTGTCATTGCATGAGA	0.423000													144	189					0	0	1	0	0
AC007040.8	0	broad.mit.edu	37	2	71256879	71256879	+	RNA	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr2:71256879G>A	ENST00000434990.1	-	0	61																											GTGTGGTGGCGTCAGTGACGT	0.547000													6	8					0	0	1	0	0
CCL3	6348	broad.mit.edu	37	17	34416559	34416559	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:34416559G>A	ENST00000225245.5	-	2	240	c.158C>T	c.(157-159)aCg>aTg	p.T53M	AC069363.1_ENST00000441575.1_RNA|AC069363.1_ENST00000592728.1_RNA|AC069363.1_ENST00000590992.1_RNA	NM_002983.2	NP_002974.1	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	53					cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity			breast(2)|lung(3)|urinary_tract(1)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTGGCTGCTCGTCTCAAAGTA	0.572000													51	49					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74524749	74524749	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr6:74524749C>T	ENST00000437994.2	+	30	4194	c.3763C>T	c.(3763-3765)Cga>Tga	p.R1255*	CD109_ENST00000287097.5_Nonsense_Mutation_p.R1272*|CD109_ENST00000422508.2_Nonsense_Mutation_p.R1195*	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	1272						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTCTAGAAGACGAAGATCTAT	0.313000													7	59					0	0	1	0	0
ATOH8	84913	broad.mit.edu	37	2	85991301	85991301	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr2:85991301G>A	ENST00000306279.3	+	2	1252	c.956G>A	c.(955-957)cGc>cAc	p.R319H	ATOH8_ENST00000463422.1_3'UTR	NM_032827.6	NP_116216.2	Q96SQ7	ATOH8_HUMAN	atonal homolog 8 (Drosophila)	319					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(1)|lung(2)	5						GCCAAGAAGCGCAAGGTATGC	0.627000													3	31					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147743499	147743499	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chrX:147743499T>C	ENST00000370460.2	+	3	730	c.251T>C	c.(250-252)tTg>tCg	p.L84S	AFF2_ENST00000342251.3_Missense_Mutation_p.L80S|AFF2_ENST00000370458.1_Missense_Mutation_p.L80S|AFF2_ENST00000370457.5_Missense_Mutation_p.L80S	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	84					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					ATGAAGAATTTGCTAACTAAC	0.403000													8	237					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167262859	167262859	+	Missense_Mutation	SNP	A	A	T			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr2:167262859A>T	ENST00000409855.1	-	25	4406	c.4280T>A	c.(4279-4281)cTt>cAt	p.L1427H		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1427					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						AACTTGAAAAAGACAGAGCAT	0.358000													57	88					0	0	1	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562495	75562495	+	Silent	SNP	G	G	T	rs138154232	by1000genomes	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr15:75562495G>T	ENST00000300576.5	+	18	2037	c.2037G>T	c.(2035-2037)ccG>ccT	p.P679P		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	679										ovary(1)	1						ACAACCCCCCGGTACAGCAGA	0.602000													6	106					3.59834e-05	3.71078e-05	1	1	0
EIF2S3	1968	broad.mit.edu	37	X	24075552	24075552	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chrX:24075552G>A	ENST00000253039.4	+	3	401	c.148G>A	c.(148-150)Gta>Ata	p.V50I		NM_001415.3	NP_001406.1	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	50						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(1)	12						AATTGGTCATGTAGCTCATGG	0.313000													30	40					0	0	1	0	0
ABI3BP	25890	broad.mit.edu	37	3	100489725	100489725	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr3:100489725G>A	ENST00000471714.1	-	61	4685	c.4576C>T	c.(4576-4578)Ccc>Tcc	p.P1526S	ABI3BP_ENST00000383691.4_Missense_Mutation_p.P778S|ABI3BP_ENST00000284322.5_Missense_Mutation_p.P824S			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	824						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TCCTCTTTGGGGAACCGTTTG	0.542000													4	79					0	0	1	0	0
FOXK1	221937	broad.mit.edu	37	7	4796757	4796757	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr7:4796757C>G	ENST00000328914.4	+	5	1183	c.1183C>G	c.(1183-1185)Cgg>Ggg	p.R395G	FOXK1_ENST00000446823.1_Missense_Mutation_p.R232G	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	395					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		ACAGGCATTCCGGAAACGGAG	0.577000													50	61					0	0	1	0	0
CXCL6	6372	broad.mit.edu	37	4	74702569	74702569	+	Silent	SNP	C	C	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr4:74702569C>G	ENST00000226317.5	+	1	356	c.102C>G	c.(100-102)ctC>ctG	p.L34L	CXCL6_ENST00000515050.1_Silent_p.L34L	NM_002993.3	NP_002984.1	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6	34					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			large_intestine(1)|lung(7)	8	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CGGGGCCCCTCGCCAGCGGTG	0.701000													19	14					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62196763	62196763	+	Missense_Mutation	SNP	T	T	A			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr20:62196763T>A	ENST00000467148.1	-	8	3481	c.3412A>T	c.(3412-3414)Acc>Tcc	p.T1138S	HELZ2_ENST00000427522.2_Missense_Mutation_p.T569S	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CGCTCGAAGGTCTCTGGCACG	0.701000													11	11					0	0	1	0	0
CROCCP3	0	broad.mit.edu	37	1	16810895	16810896	+	RNA	INS	-	-	GGAGTCATCC			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr1:16810895_16810896insGGAGTCATCC	ENST00000263511.4	-	0	1635_1636					NR_023386.1																						AGGCTGCCGAAGGAGTCATCCG	0.743													3	5	---	---	---	---					
ZCWPW2	152098	broad.mit.edu	37	3	28555576	28555577	+	Frame_Shift_Ins	INS	-	-	C			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr3:28555576_28555577insC	ENST00000383768.2	+	7	867_868	c.679_680insC	c.(679-681)tgafs	p.*227fs	ZCWPW2_ENST00000421010.1_Frame_Shift_Ins_p.*227fs			Q504Y3	ZCPW2_HUMAN	zinc finger, CW type with PWWP domain 2	227							zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(6)|ovary(2)	17						TAAAAATAATATTGAAAAGAAG	0.257													17	29	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172992494	172992494	+	RNA	DEL	C	C	-	rs79222726		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr3:172992494delC	ENST00000447709.1	+	0	216																											aacaaacaaacaaaaacatgt	0.512													9	6	---	---	---	---					
FIP1L1	81608	broad.mit.edu	37	4	54319248	54319249	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr4:54319248_54319249delAG	ENST00000337488.6	+	16	1641_1642	c.1447_1448delAG	c.(1447-1449)afs	p.R483fs	FIP1L1_ENST00000507166.1_Intron|FIP1L1_ENST00000306932.6_Frame_Shift_Del_p.R409fs|FIP1L1_ENST00000358575.5_Frame_Shift_Del_p.R477fs	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	483	Arg-rich.|Glu-rich.|Sufficient for interaction with CPSF1 and CSTF3.				mRNA processing	nucleus	RNA binding	p.R487fs*3(2)		large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			agaACGCACCAGAGAGAGAGAG	0.470			T	PDGFRA	idiopathic hypereosinophilic syndrome								7	56	---	---	---	---					
SNRNP48	154007	broad.mit.edu	37	6	7594048	7594048	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr6:7594048delT	ENST00000342415.5	+	2	297	c.238delT	c.(238-240)tgfs	p.L80fs		NM_152551.3	NP_689764.3	Q6IEG0	SNR48_HUMAN	small nuclear ribonucleoprotein 48kDa (U11/U12)	80					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding			kidney(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						ATCTTGTAGATTGAGGAAAAT	0.308													43	56	---	---	---	---					
PTPN12	0	broad.mit.edu	37	7	77256691	77256692	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr7:77256691_77256692delTG	ENST00000248594.6	+	13	1967_1968	c.1695_1696delTG	c.(1693-1698)actgfs	p.TV565fs	PTPN12_ENST00000415482.2_Frame_Shift_Del_p.TV446fs|PTPN12_ENST00000435495.2_Frame_Shift_Del_p.TV435fs	NM_002835.3	NP_002826.3	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type 12	565						soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(12)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	39						CTAGGAAAACTGTGAGTTTAAC	0.396													8	122	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149483379	149483379	+	RNA	DEL	C	C	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr7:149483379delC	ENST00000378016.2	+	0	3379							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTTGAACTCACCCCAACTTCT	0.617													2	4	---	---	---	---					
PCSK5	5125	broad.mit.edu	37	9	78790207	78790208	+	Frame_Shift_Ins	INS	-	-	GAATA	rs55947300		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr9:78790207_78790208insGAATA	ENST00000376767.3	+	14	2574_2575	c.2062_2063insGAATA	c.(2062-2064)aatfs	p.N688fs	PCSK5_ENST00000545128.1_Intron|PCSK5_ENST00000376752.4_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						cgaatcgaatcgaatagaatag	0.342													4	7	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651199	1651200	+	In_Frame_Ins	INS	-	-	GGCTGTGGCTCC	rs71025763		TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr11:1651199_1651200insGGCTGTGGCTCC	ENST00000399676.2	+	1	167_168	c.129_130insGGCTGTGGCTCC	c.(127-132)gggctg>ggGGCTGTGGCTCCgctg	p.43_44GL>GAVAPL		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	43				G -> GGCGS (in Ref. 1; BAD20201 and 2; CAF31639).		keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		ccggctgtggaggctgtggggg	0.713													42	27	---	---	---	---					
EP400	57634	broad.mit.edu	37	12	132547093	132547094	+	In_Frame_Ins	INS	-	-	CAG	rs113304321	by1000genomes	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr12:132547093_132547094insCAG	ENST00000333577.4	+	48	8398_8399	c.8289_8290insCAG	c.(8287-8292)caagca>caCAGagca	p.2763_2763Q>HR	EP400_ENST00000330386.6_In_Frame_Ins_p.2646_2646Q>HR|EP400_ENST00000332482.4_In_Frame_Ins_p.2690_2690Q>HR|EP400_ENST00000389561.2_In_Frame_Ins_p.2727_2727Q>HR|EP400_ENST00000389562.2_In_Frame_Ins_p.2726_2726Q>HR			Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2726Q(9)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagca	0.564													16	35	---	---	---	---					
IGHV3-11	0	broad.mit.edu	37	14	106573362	106573364	+	RNA	DEL	ACC	ACC	-	rs2003432	by1000genomes	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr14:106573362_106573364delACC	ENST00000390601.2	-	0	339_341																											ATATGGTACTACCACTACTACTA	0.522													7	510	---	---	---	---					
TCF12	6938	broad.mit.edu	37	15	57545486	57545487	+	Frame_Shift_Ins	INS	-	-	ATCT			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr15:57545486_57545487insATCT	ENST00000267811.5	+	15	1519_1520	c.1215_1216insATCT	c.(1213-1218)gagactfs	p.T406fs	TCF12_ENST00000537840.1_Frame_Shift_Ins_p.T170fs|TCF12_ENST00000343827.3_Frame_Shift_Ins_p.T236fs|TCF12_ENST00000333725.5_Frame_Shift_Ins_p.T430fs|TCF12_ENST00000560764.1_3'UTR|TCF12_ENST00000559703.1_Frame_Shift_Ins_p.T64fs|TCF12_ENST00000438423.2_Frame_Shift_Ins_p.T430fs|TCF12_ENST00000559710.1_Frame_Shift_Ins_p.T40fs|TCF12_ENST00000557843.1_Frame_Shift_Ins_p.T406fs|TCF12_ENST00000543579.1_Frame_Shift_Ins_p.T260fs|TCF12_ENST00000452095.2_Frame_Shift_Ins_p.T426fs	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12	406					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		ATCGTTTAGACAGACTGGATGA	0.441			T	TEC	extraskeletal myxoid chondrosarcoma								24	44	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7751762	7751763	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:7751762_7751763insG	ENST00000254846.5	+	11	2545_2546	c.2156_2157insG	c.(2155-2157)ggcfs	p.G719fs	KDM6B_ENST00000448097.2_Frame_Shift_Ins_p.G719fs	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	719	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						GAAGCAGGCGTGGCCCCCCAAC	0.584													10	102	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													93	38	---	---	---	---					
MYO5B	4645	broad.mit.edu	37	18	47455945	47455945	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr18:47455945delT	ENST00000285039.7	-	17	2326	c.2027delA	c.(2026-2028)cgfs	p.Q677fs		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	677	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TCTGAGTTGCTGCACTGCTCT	0.493													8	14	---	---	---	---					
CYP4F8	11283	broad.mit.edu	37	19	15733290	15733293	+	RNA	DEL	GAGA	GAGA	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr19:15733290_15733293delGAGA	ENST00000441682.2	+	0	708							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						aggagagaaggagagagagagaga	0.515													5	2	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36696948	36696950	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-DU-5870-02A-12D-A36O-08	TCGA-DU-5870-10A-01D-1705-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6c817e3c-a1ee-48a2-a8a9-85b0cf894b1b	8ecfbf90-3948-4e91-9eae-d052e56fdb4f	g.chr22:36696948_36696950delCTC	ENST00000216181.5	-	22	3015_3017	c.2785_2787delGAG	c.(2785-2787)del	p.E929del		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	929					actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						GCTGGCAGCGCTCCTCCTCCTCC	0.665			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				7	87	---	---	---	---