Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZBTB45	84878	broad.mit.edu	37	19	59028510	59028510	+	Silent	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr19:59028510C>T	ENST00000594051.1	-	2	1011	c.531G>A	c.(529-531)gcG>gcA	p.A177A	ZBTB45_ENST00000354590.3_Silent_p.A177A|ZBTB45_ENST00000600990.1_Silent_p.A177A			Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	177	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|urinary_tract(1)	11		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GCTGCAAACGCGCGGGCTGGC	0.711000											OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	24					0	0	1	0	0
LHX2	9355	broad.mit.edu	37	9	126777629	126777629	+	Silent	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr9:126777629C>T	ENST00000373615.4	+	3	1291	c.552C>T	c.(550-552)gcC>gcT	p.A184A		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	184						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						TCAACCATGCCGACGTGGCAG	0.692000													13	22					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23411556	23411556	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chrX:23411556G>A	ENST00000379361.4	+	3	2781	c.1921G>A	c.(1921-1923)Gat>Aat	p.D641N		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	641					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						TGATGAGGTCGATGTAGTGGC	0.403000													17	50					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr16:90162513T>C	ENST00000567960.1	+	0	1249				TUBB8P7_ENST00000564451.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													4	61					0	0	1	0	0
PET112	5188	broad.mit.edu	37	4	152682113	152682113	+	Missense_Mutation	SNP	A	A	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr4:152682113A>T	ENST00000263985.6	-	1	62	c.22T>A	c.(22-24)Tgg>Agg	p.W8R	PET112_ENST00000512306.1_Missense_Mutation_p.W8R|PET112_ENST00000508611.1_Missense_Mutation_p.W8R|PET112_ENST00000515812.1_Missense_Mutation_p.W8R	NM_004564.2	NP_004555.1	O75879	GATB_HUMAN	PET112 homolog (yeast)	8						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	23					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CGGCAGCCCCAGCGCAGCATG	0.622000													12	24					0	0	1	0	0
ANKLE2	23141	broad.mit.edu	37	12	133324458	133324458	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr12:133324458C>T	ENST00000539605.1	-	4	7688	c.1004G>A	c.(1003-1005)cGt>cAt	p.R335H	ANKLE2_ENST00000337516.5_Missense_Mutation_p.R397H|ANKLE2_ENST00000357997.5_Missense_Mutation_p.R397H			Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	397						cytoplasm|integral to membrane|nuclear envelope				NS(2)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|lung(20)|ovary(1)|urinary_tract(2)	45	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CACCACGTAACGGATACGCTT	0.527000													11	27					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	67023790	67023790	+	Silent	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr17:67023790C>T	ENST00000340001.4	-	13	1993	c.1782G>A	c.(1780-1782)gtG>gtA	p.V594V	ABCA9_ENST00000370732.2_Silent_p.V594V|ABCA9_ENST00000453985.2_Silent_p.V594V	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	594	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					CCTCTTTCTCCACTTCATGTG	0.353000													12	31					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								12	16					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41687760	41687760	+	Missense_Mutation	SNP	C	C	T	rs147660035		TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr4:41687760C>T	ENST00000313860.7	+	23	2903	c.2849C>T	c.(2848-2850)aCg>aTg	p.T950M	LIMCH1_ENST00000512820.1_Missense_Mutation_p.T962M|LIMCH1_ENST00000511496.1_Missense_Mutation_p.T790M|LIMCH1_ENST00000514096.1_Missense_Mutation_p.T790M|LIMCH1_ENST00000503057.1_Missense_Mutation_p.T1334M|LIMCH1_ENST00000513024.1_Missense_Mutation_p.T803M|LIMCH1_ENST00000381753.4_Missense_Mutation_p.T783M|LIMCH1_ENST00000512946.1_Missense_Mutation_p.T950M|LIMCH1_ENST00000509277.1_Missense_Mutation_p.T783M|LIMCH1_ENST00000512632.1_Missense_Mutation_p.T873M|LIMCH1_ENST00000508501.1_Missense_Mutation_p.T949M|LIMCH1_ENST00000396595.3_Missense_Mutation_p.T795M	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	950					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TCAAATCCAACGCACAGTTCA	0.443000													14	31					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121671570	121671570	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr7:121671570T>C	ENST00000393386.2	+	15	5534	c.5123T>C	c.(5122-5124)gTt>gCt	p.V1708A	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.V848A	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1708					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CCAAAGCATGTTGCAGATTTA	0.279000													13	34					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72685542	72685542	+	RNA	SNP	G	G	A	rs2539086		TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr7:72685542G>A	ENST00000425256.1	-	0	116					NR_002164.1																						ACGTTACCATGACAAAAGCAG	0.463000													4	54					0	0	1	0	0
LDB3	11155	broad.mit.edu	37	10	88439245	88439245	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr10:88439245C>T	ENST00000429277.2	+	3	360	c.215C>T	c.(214-216)gCc>gTc	p.A72V	LDB3_ENST00000458213.2_Missense_Mutation_p.A72V|LDB3_ENST00000372056.4_Missense_Mutation_p.A72V|LDB3_ENST00000361373.4_Missense_Mutation_p.A72V|LDB3_ENST00000263066.6_Missense_Mutation_p.A72V|LDB3_ENST00000372066.3_Missense_Mutation_p.A72V|LDB3_ENST00000352360.5_Missense_Mutation_p.A72V|LDB3_ENST00000310944.6_Missense_Mutation_p.A72V|LDB3_ENST00000542786.1_Missense_Mutation_p.A72V	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	72	PDZ.					cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						ATCAAGTCTGCCAGCTACAAC	0.617000													3	46					0	0	1	0	0
UBBP4	0	broad.mit.edu	37	17	21730852	21730852	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr17:21730852G>C	ENST00000584755.1	+	2	551	c.154G>C	c.(154-156)Gat>Cat	p.D52H	UBBP4_ENST00000578713.1_Missense_Mutation_p.D52H|UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GCAGCGGGAAGATGGCCGCAG	0.522000													7	21					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771878	143771878	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr7:143771878C>T	ENST00000408898.2	+	1	604	c.566C>T	c.(565-567)gCg>gTg	p.A189V		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	189					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A189E(1)|p.A189V(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					CTTGCCTGTGCGGATACCCAC	0.433000													26	77					0	0	1	0	0
IBSP	3381	broad.mit.edu	37	4	88731862	88731862	+	Silent	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr4:88731862C>T	ENST00000226284.5	+	6	418	c.351C>T	c.(349-351)gaC>gaT	p.D117D		NM_004967.3	NP_004958.2	P21815	SIAL_HUMAN	integrin-binding sialoprotein	117	Asp/Glu-rich (acidic).				biomineral tissue development|cell adhesion|ossification					breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)	21		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000333)|COAD - Colon adenocarcinoma(81;0.154)		ATGGAGAGGACGCCACGCCTG	0.423000													15	50					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91338462	91338462	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr14:91338462T>C	ENST00000261991.3	-	17	2538	c.2365A>G	c.(2365-2367)Aat>Gat	p.N789D	RPS6KA5_ENST00000536315.2_Missense_Mutation_p.N710D	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	789					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		TCCGGGTTATTGCTGTCGGCA	0.512000													13	43					0	0	1	0	0
SCARB2	950	broad.mit.edu	37	4	77100703	77100703	+	Silent	SNP	G	G	T	rs148029250	by1000genomes	TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr4:77100703G>T	ENST00000264896.2	-	4	928	c.579C>A	c.(577-579)ccC>ccA	p.P193P	SCARB2_ENST00000452464.2_Intron	NM_005506.3	NP_005497.1	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	193					cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(3)|prostate(2)|skin(1)	22			Lung(101;0.196)			GAGAGATATCGGGCCTGAAAA	0.443000													3	65					6.4e-05	6.4e-05	1	1	0
TMEM95	339168	broad.mit.edu	37	17	7258606	7258606	+	Missense_Mutation	SNP	C	C	T	rs150578277		TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr17:7258606C>T	ENST00000389982.4	+	1	165	c.83C>T	c.(82-84)tCa>tTa	p.S28L	TMEM95_ENST00000330767.4_Missense_Mutation_p.S28L|TMEM95_ENST00000576060.1_Missense_Mutation_p.S28L			Q3KNT9	TMM95_HUMAN	transmembrane protein 95	28						integral to membrane				large_intestine(1)|lung(2)	3		Prostate(122;0.173)				CACGACTTGTCAGGCCGCCTG	0.637000													12	23					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	375793	375793	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr19:375793G>A	ENST00000342640.4	-	1	220	c.178C>T	c.(178-180)Cca>Tca	p.P60S	THEG_ENST00000346878.2_Missense_Mutation_p.P60S	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	60					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTCTTCTGGGTCTTCTGGT	0.642000													20	36					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791721	42791721	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr19:42791721C>T	ENST00000572681.2	+	6	3402	c.3334C>T	c.(3334-3336)Ccc>Tcc	p.P1112S	CIC_ENST00000160740.3_Missense_Mutation_p.P203S|CIC_ENST00000575354.2_Missense_Mutation_p.P203S			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	203	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CATCCGGCGGCCCATGAATGC	0.627000			"""Mis, F, S"""		oligodendroglioma								17	15					0	0	1	0	0
USP24	23358	broad.mit.edu	37	1	55569612	55569612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr1:55569612delA	ENST00000294383.6	-	42	4961	c.4962delT	c.(4960-4962)atfs	p.I1656fs	USP24_ENST00000407756.1_Frame_Shift_Del_p.I1496fs	NM_015306.2	NP_056121.2	Q9UPU5	UBP24_HUMAN	ubiquitin specific peptidase 24	1656					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|cervix(1)|endometrium(8)|kidney(13)|large_intestine(7)|lung(16)|ovary(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	60						CTTTTATAATAATTTGAAGAT	0.383													2	4	---	---	---	---					
FUBP1	8880	broad.mit.edu	37	1	78430388	78430389	+	Frame_Shift_Ins	INS	-	-	AG			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr1:78430388_78430389insAG	ENST00000370767.1	-	10	866_867	c.779_780insCT	c.(778-780)gttfs	p.V260fs	FUBP1_ENST00000436586.2_Frame_Shift_Ins_p.V281fs|FUBP1_ENST00000370768.2_Frame_Shift_Ins_p.V260fs			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	260					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						CTTCTCTGAAACCGCCTTGATC	0.347			"""F, N"""		oligodendroglioma								31	62	---	---	---	---					
RP11-739N20.2	0	broad.mit.edu	37	1	204363978	204363979	+	RNA	INS	-	-	AA			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr1:204363978_204363979insAA	ENST00000443515.1	+	0	146																											gatttgtttttcaaaaaaaaaa	0.302													2	4	---	---	---	---					
PRSS3P2	0	broad.mit.edu	37	7	142482025	142482025	+	RNA	DEL	A	A	-			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr7:142482025delA	ENST00000603901.1	+	0	591					NR_001296.3																						TGCAGTGCCCACATGGAGAAG	0.572													2	4	---	---	---	---					
MAST3	23031	broad.mit.edu	37	19	18234405	18234405	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DU-A6S2-01A-21D-A32B-08	TCGA-DU-A6S2-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5d3cef6-c768-44ae-934f-fd728808a0e0	7ef54b90-9886-4974-9edf-81deb8bc2af2	g.chr19:18234405delG	ENST00000262811.5	+	7	486	c.486delG	c.(484-486)acfs	p.T162fs		NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	162							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						GCCGTGCAACGGGGACCTTCG	0.607													2	4	---	---	---	---