Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYOM2	9172	broad.mit.edu	37	8	2037956	2037956	+	Silent	SNP	G	G	A	rs146528852		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr8:2037956G>A	ENST00000262113.4	+	15	1911	c.1770G>A	c.(1768-1770)cgG>cgA	p.R590R	MYOM2_ENST00000523438.1_Silent_p.R15R	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	590	Fibronectin type-III 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CAGCAAACCGGCATGGCCTGA	0.572000													3	36					0	0	1	0	0
ST8SIA6	338596	broad.mit.edu	37	10	17362896	17362896	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:17362896C>T	ENST00000377602.4	-	8	1252	c.1178G>A	c.(1177-1179)aGc>aAc	p.S393N		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	393					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						TTCACATTTGCTAAATTGCAG	0.378000													92	130					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10908075	10908075	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:10908075G>A	ENST00000314646.5	+	10	1380	c.1216G>A	c.(1216-1218)Gac>Aac	p.D406N	DNM2_ENST00000408974.4_Missense_Mutation_p.D406N|DNM2_ENST00000585892.1_Intron|DNM2_ENST00000355667.6_Intron|DNM2_ENST00000359692.6_Intron|DNM2_ENST00000389253.4_Missense_Mutation_p.D406N			P50570	DYN2_HUMAN	dynamin 2	406					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			CTTCACCCCCGACATGGCCTT	0.547000			"""F, N, Splice, Mis, O"""		ETP ALL								5	26					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56423307	56423307	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:56423307C>T	ENST00000588751.1	-	5	1900	c.1876G>A	c.(1876-1878)Gct>Act	p.A626T	NLRP13_ENST00000342929.3_Missense_Mutation_p.A626T			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	626							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GCACTTTCAGCCTTACCTAAC	0.403000													13	24					0	0	1	0	0
IRAK1	3654	broad.mit.edu	37	X	153284093	153284093	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:153284093G>A	ENST00000369980.3	-	5	853	c.686C>T	c.(685-687)gCg>gTg	p.A229V	IRAK1_ENST00000393687.2_Missense_Mutation_p.A229V|IRAK1_ENST00000369974.2_Missense_Mutation_p.A229V|IRAK1_ENST00000429936.2_Missense_Mutation_p.A255V|IRAK1_ENST00000477274.1_5'UTR|IRAK1_ENST00000393682.1_Missense_Mutation_p.A255V	NM_001025242.1|NM_001569.3	NP_001020413.1|NP_001560.2	P51617	IRAK1_HUMAN	interleukin-1 receptor-associated kinase 1	229	Protein kinase.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|innate immune response|interleukin-1-mediated signaling pathway|JNK cascade|lipopolysaccharide-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription, DNA-dependent|protein autophosphorylation|protein oligomerization|regulation of cytokine-mediated signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway	cytosol|endosome membrane|interleukin-1 receptor complex	ATP binding|NF-kappaB-inducing kinase activity|protein binding|protein heterodimerization activity|protein homodimerization activity|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(15)|ovary(2)	25	all_cancers(53;3.7e-16)|all_epithelial(53;3.44e-10)|all_lung(58;2.06e-07)|Lung NSC(58;2.72e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCTCATCACCGCCCGGTACAC	0.592000													20	160					0	0	1	0	0
NR0B1	190	broad.mit.edu	37	X	30327411	30327411	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:30327411G>A	ENST00000378970.4	-	1	304	c.70C>T	c.(70-72)Cgc>Tgc	p.R24C	NR0B1_ENST00000453287.1_Missense_Mutation_p.R24C	NM_000475.4	NP_000466.2	P51843	NR0B1_HUMAN	nuclear receptor subfamily 0, group B, member 1	24	4 X 67 AA tandem repeats.				adrenal gland development|hypothalamus development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of steroid hormone receptor signaling pathway|pituitary gland development|protein localization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|steroid biosynthetic process	cytoplasm|membrane fraction|nucleoplasm|nucleus|polysomal ribosome	AF-2 domain binding|DNA hairpin binding|ligand-regulated transcription factor activity|protein domain specific binding|protein homodimerization activity|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|steroid hormone receptor binding|transcription corepressor activity|transcription factor binding			central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	24					Dexamethasone(DB01234)|Tretinoin(DB00755)	GGAGCCGCGCGCGTTTGCTTC	0.692000													8	13					0	0	1	0	0
ICOSLG	23308	broad.mit.edu	37	21	45658330	45658330	+	Splice_Site	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr21:45658330C>T	ENST00000407780.3	-	2	183		c.e2+1		ICOSLG_ENST00000400377.3_Splice_Site|ICOSLG_ENST00000344330.4_Splice_Site|ICOSLG_ENST00000400379.3_Splice_Site			O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand						B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding			endometrium(2)|lung(1)|stomach(1)|urinary_tract(1)	5				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		CCTGAACTTACCAGCTCGAAG	0.612000													8	14					0	0	1	0	0
TNKS2	80351	broad.mit.edu	37	10	93590720	93590720	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:93590720T>C	ENST00000371627.4	+	10	1524	c.1145T>C	c.(1144-1146)aTa>aCa	p.I382T		NM_025235.3	NP_079511.1	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	382					positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			biliary_tract(1)|breast(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	48		Colorectal(252;0.162)				AGAAAGCAAATATGTGAACTG	0.294000													4	29					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28916444	28916444	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr18:28916444A>G	ENST00000257192.4	+	9	1345	c.1133A>G	c.(1132-1134)aAt>aGt	p.N378S		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	378	Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			ACTGTGTTAAATGTAATTGAA	0.363000													12	56					0	0	1	0	0
IGF1	3479	broad.mit.edu	37	12	102813295	102813295	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr12:102813295T>C	ENST00000456098.1	-	3	612	c.394A>G	c.(394-396)Acc>Gcc	p.T132A	IGF1_ENST00000337514.6_Missense_Mutation_p.T132A|IGF1_ENST00000424202.2_Missense_Mutation_p.T116A|IGF1_ENST00000307046.8_Missense_Mutation_p.T132A|IGF1_ENST00000392904.1_Missense_Mutation_p.T132A	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	132					anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						ACCTTCTGGGTCTTGGGCATG	0.592000													14	21					0	0	1	0	0
KLHL26	55295	broad.mit.edu	37	19	18775153	18775153	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:18775153C>T	ENST00000300976.4	+	2	256	c.166C>T	c.(166-168)Ctc>Ttc	p.L56F	KLHL26_ENST00000596843.1_3'UTR|KLHL26_ENST00000595182.1_Missense_Mutation_p.L56F|KLHL26_ENST00000599006.1_Missense_Mutation_p.L56F	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	56										breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CCTGGCCACCCTCCGCGCTCA	0.637000													54	68					0	0	1	0	0
TRIM2	23321	broad.mit.edu	37	4	154216540	154216540	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr4:154216540G>A	ENST00000338700.5	+	6	927	c.862G>A	c.(862-864)Gcc>Acc	p.A288T	TRIM2_ENST00000494872.1_3'UTR|TRIM2_ENST00000437508.2_Missense_Mutation_p.A261T	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	261						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		CACAGCGCAGGCCCTCAACCA	0.617000													10	2					0	0	1	0	0
LANCL1	10314	broad.mit.edu	37	2	211302538	211302538	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:211302538T>C	ENST00000443314.1	-	6	1091	c.749A>G	c.(748-750)tAc>tGc	p.Y250C	LANCL1_ENST00000441020.3_Missense_Mutation_p.Y250C|AC007970.1_ENST00000433296.1_RNA|AC007970.1_ENST00000420418.1_RNA|LANCL1_ENST00000431941.2_Missense_Mutation_p.Y250C|LANCL1_ENST00000450366.2_Missense_Mutation_p.Y250C|LANCL1_ENST00000233714.4_Missense_Mutation_p.Y250C			O43813	LANC1_HUMAN	LanC lantibiotic synthetase component C-like 1 (bacterial)	250						cytoplasm|integral to plasma membrane|microtubule cytoskeleton|nucleus	catalytic activity|G-protein coupled receptor activity|glutathione binding|low-density lipoprotein particle receptor binding|SH3 domain binding|zinc ion binding			breast(1)|large_intestine(5)|liver(1)|lung(4)|prostate(1)	12				Epithelial(149;0.00562)|Lung(261;0.0468)|LUSC - Lung squamous cell carcinoma(261;0.0495)|all cancers(144;0.0569)		CTGGCAGACGTAGTCTACACT	0.463000													5	56					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20783011	20783011	+	Silent	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr12:20783011T>C	ENST00000359062.3	+	6	1750	c.1710T>C	c.(1708-1710)agT>agC	p.S570S	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	570					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	ACACTCAGAGTGCCCCAGACC	0.423000													39	139					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197070715	197070715	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr1:197070715C>T	ENST00000367409.4	-	18	7922	c.7666G>A	c.(7666-7668)Gct>Act	p.A2556T	ASPM_ENST00000294732.7_Intron|ASPM_ENST00000367408.1_Intron	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	2556	IQ 27.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						ACGATAGAAGCTTTGTGTTTT	0.348000													20	53					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44979079	44979079	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr20:44979079C>G	ENST00000372227.1	-	10	1592	c.1052G>C	c.(1051-1053)gGt>gCt	p.G351A	SLC35C2_ENST00000243896.2_Missense_Mutation_p.G351A|SLC35C2_ENST00000372230.5_Missense_Mutation_p.G351A|SLC35C2_ENST00000493599.1_5'UTR|SLC35C2_ENST00000372229.1_Missense_Mutation_p.G218A|SLC35C2_ENST00000317734.8_Missense_Mutation_p.G330A|SLC35C2_ENST00000543605.1_Missense_Mutation_p.G380A			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	351					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				CTCATTGTCACCTTCCTCCCG	0.642000													18	44					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr16:90161926T>C	ENST00000564451.1	+	0	1279				TUBB8P7_ENST00000567960.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													3	28					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542921	14542921	+	Silent	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr18:14542921G>A	ENST00000358970.5	-	1	224	c.225C>T	c.(223-225)agC>agT	p.S75S	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	75								p.S75S(1)|p.S75R(1)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TGCTCGTGCCGCTCCCCCTGC	0.567000													28	222					0	0	1	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998106	27998106	+	Missense_Mutation	SNP	C	C	A	rs138650117		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:27998106C>A	ENST00000441525.1	-	1	1460	c.1346G>T	c.(1345-1347)cGg>cTg	p.R449L		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	449								p.R449L(1)		NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						AAACTCACTCCGGGGGCCATA	0.463000													3	33					0.00024832	0.000258962	1	1	0
SLC17A9	63910	broad.mit.edu	37	20	61594021	61594021	+	Silent	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr20:61594021C>T	ENST00000370349.3	+	6	729	c.525C>T	c.(523-525)taC>taT	p.Y175Y	SLC17A9_ENST00000370351.4_Silent_p.Y181Y|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	181					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						TGGAATGGTACGGCTGGCAGA	0.637000													10	78					0	0	1	0	0
NXT2	55916	broad.mit.edu	37	X	108780167	108780167	+	Splice_Site	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:108780167C>T	ENST00000218004.1	+	2	199	c.95_splice	c.e2-1	p.P33_splice	NXT2_ENST00000372106.1_5'UTR|NXT2_ENST00000372107.1_5'UTR	NM_018698.4	NP_061168.2	Q9NPJ8	NXT2_HUMAN	nuclear transport factor 2-like export factor 2	0	NTF2.				mRNA transport|protein transport	cytoplasm|nucleus				endometrium(3)|large_intestine(1)|lung(1)|ovary(1)	6						ATTCCGCAGCCCTGCGGACCG	0.572000													12	12					0	0	1	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26124122	26124122	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr6:26124122G>A	ENST00000314332.5	-	1	16	c.11C>T	c.(10-12)cCa>cTa	p.P4L	HIST1H2BC_ENST00000396984.1_Missense_Mutation_p.P4L			P62807	H2B1C_HUMAN	histone cluster 1, H2bc	4					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(9)|ovary(1)	16						AGACTTGGCTGGCTCAGGCAT	0.507000													8	102					0	0	1	0	0
PKP3	11187	broad.mit.edu	37	11	399104	399104	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:399104A>G	ENST00000331563.2	+	5	1257	c.1181A>G	c.(1180-1182)gAc>gGc	p.D394G		NM_007183.2	NP_009114.1	Q9Y446	PKP3_HUMAN	plakophilin 3	394					cell adhesion	desmosome|nucleus	binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(49;3.02e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GACAACGCTGACAACAAGCTG	0.597000													6	36					0	0	1	0	0
ACTRT2	140625	broad.mit.edu	37	1	2938806	2938806	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr1:2938806G>A	ENST00000378404.2	+	1	761	c.556G>A	c.(556-558)Ggc>Agc	p.G186S		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	186						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		CCACGTGGCGGGCAGGGACAT	0.637000													6	20					0	0	1	0	0
CKAP5	9793	broad.mit.edu	37	11	46782334	46782334	+	Splice_Site	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:46782334G>A	ENST00000529230.1	-	33	4268	c.4221_splice	c.e33-1	p.L1408_splice	CKAP5_ENST00000354558.3_Splice_Site_p.L1408_splice|CKAP5_ENST00000415402.1_Splice_Site_p.L1408_splice|CKAP5_ENST00000312055.5_Splice_Site_p.L1408_splice			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1408					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						TTTTCAGAAAGCTGTAAAGAG	0.388000													7	43					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52573649	52573649	+	Silent	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:52573649A>G	ENST00000395489.2	-	12	1690	c.1294T>C	c.(1294-1296)Tta>Cta	p.L432L	A1CF_ENST00000395495.1_Silent_p.L384L|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000282641.2_Silent_p.L439L|A1CF_ENST00000373993.1_Silent_p.L439L|A1CF_ENST00000374001.1_Silent_p.L431L|A1CF_ENST00000373997.3_Silent_p.L431L|A1CF_ENST00000373995.3_Silent_p.L439L|ASAH2B_ENST00000483649.1_Intron	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	439					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						TGGGGTTTTAATGTGACAGGA	0.418000													17	117					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791818	42791818	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:42791818G>A	ENST00000572681.2	+	6	3499	c.3431G>A	c.(3430-3432)gGc>gAc	p.G1144D	CIC_ENST00000160740.3_Missense_Mutation_p.G235D|CIC_ENST00000575354.2_Missense_Mutation_p.G235D			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	235	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				AAGATCCTGGGCGAGTGGTGG	0.612000			"""Mis, F, S"""		oligodendroglioma								24	9					0	0	1	0	0
IFIT5	24138	broad.mit.edu	37	10	91178247	91178247	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:91178247A>G	ENST00000371795.4	+	2	1504	c.1291A>G	c.(1291-1293)Aat>Gat	p.N431D	IFIT5_ENST00000416601.1_Missense_Mutation_p.N383D	NM_012420.2	NP_036552.1	Q13325	IFIT5_HUMAN	interferon-induced protein with tetratricopeptide repeats 5	431							binding			endometrium(1)|large_intestine(4)|lung(4)	9						ACTTTGTCACAATGCTTTAGA	0.423000													21	72					0	0	1	0	0
CXorf66	347487	broad.mit.edu	37	X	139038428	139038428	+	Missense_Mutation	SNP	T	T	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:139038428T>G	ENST00000370540.1	-	3	736	c.713A>C	c.(712-714)aAg>aCg	p.K238T		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	238						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						TTTGGGAGGCTTAGCCAATTC	0.438000													132	156					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48221160	48221160	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr16:48221160A>G	ENST00000394747.1	-	20	3234	c.2885T>C	c.(2884-2886)aTc>aCc	p.I962T	ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000353782.5_Missense_Mutation_p.I962T|ABCC11_ENST00000356608.2_Missense_Mutation_p.I962T|ABCC11_ENST00000537808.1_3'UTR|ABCC11_ENST00000394748.1_Missense_Mutation_p.I962T	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	962	ABC transmembrane type-1 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CATTAACAGGATATATGGAGA	0.468000													29	24					0	0	1	0	0
CEP85L	387119	broad.mit.edu	37	6	118953718	118953718	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr6:118953718T>C	ENST00000368491.3	-	2	751	c.130A>G	c.(130-132)Act>Gct	p.T44A	CEP85L_ENST00000360290.3_5'UTR|CEP85L_ENST00000419517.2_Missense_Mutation_p.T44A|CEP85L_ENST00000392500.3_Missense_Mutation_p.T47A|CEP85L_ENST00000368488.5_Missense_Mutation_p.T47A	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	44						centrosome											GATGGAACAGTTGTGGCCTGC	0.423000													39	45					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43851147	43851147	+	Missense_Mutation	SNP	C	C	T	rs140069155		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr20:43851147C>T	ENST00000372769.3	+	2	964	c.874C>T	c.(874-876)Cgt>Tgt	p.R292C		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	292	4 X 60 AA tandem repeats, type I.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity	p.R292S(1)		autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				CCCGTCTTCACGTACAGAAGA	0.393000													41	67					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21897261	21897261	+	Silent	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr14:21897261T>C	ENST00000399982.2	-	2	1141	c.1077A>G	c.(1075-1077)tcA>tcG	p.S359S	CHD8_ENST00000430710.3_Silent_p.S80S|CHD8_ENST00000557364.1_Silent_p.S359S|CHD8_ENST00000555962.1_Intron	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	359	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		GTGGCTGCGATGATGGTGGTT	0.557000													8	75					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								26	32					0	0	1	0	0
OPN1LW	5956	broad.mit.edu	37	X	153418564	153418564	+	Silent	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:153418564C>T	ENST00000369951.4	+	3	621	c.561C>T	c.(559-561)ccC>ccT	p.P187P	OPN1LW_ENST00000463296.1_3'UTR	NM_020061.4	NP_064445.1	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	187					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	15	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGCCCCGCCCATCTTTGGTT	0.567000													9	35					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185637	127185637	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:127185637C>T	ENST00000371124.3	-	1	745	c.549G>A	c.(547-549)atG>atA	p.M183I		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	183						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CCCTCCCTGCCATACAGAGTT	0.542000													40	68					0	0	1	0	0
C11orf16	56673	broad.mit.edu	37	11	8947615	8947615	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:8947615C>T	ENST00000326053.5	-	5	705	c.599G>A	c.(598-600)gGc>gAc	p.G200D	C11orf16_ENST00000525780.1_Missense_Mutation_p.G200D	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	200										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		AGCAGCTTTGCCATTCCAGAA	0.428000													4	111					0	0	1	0	0
C7orf10	79783	broad.mit.edu	37	7	40535964	40535964	+	Missense_Mutation	SNP	G	G	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr7:40535964G>C	ENST00000309930.5	+	12	1113	c.1089G>C	c.(1087-1089)aaG>aaC	p.K363N	C7orf10_ENST00000335693.4_Missense_Mutation_p.K363N|C7orf10_ENST00000401647.2_Missense_Mutation_p.K315N	NM_001193311.1|NM_024728.2	NP_001180240.1|NP_079004.1	Q9HAC7	CG010_HUMAN	chromosome 7 open reading frame 10	363							transferase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)	18						ACAACATGAAGAATGTATTTG	0.403000													8	7					0	0	1	0	0
ACSBG1	23205	broad.mit.edu	37	15	78474344	78474344	+	Silent	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr15:78474344G>A	ENST00000258873.4	-	8	1243	c.1038C>T	c.(1036-1038)gcC>gcT	p.A346A	ACSBG1_ENST00000541759.1_Silent_p.A104A|ACSBG1_ENST00000560817.1_Silent_p.A104A	NM_001199377.1|NM_015162.4	NP_001186306.1|NP_055977.3	Q96GR2	ACBG1_HUMAN	acyl-CoA synthetase bubblegum family member 1	346					long-chain fatty acid metabolic process|myelination|very long-chain fatty acid metabolic process	cytoplasmic membrane-bounded vesicle|endoplasmic reticulum|microsome	ATP binding|long-chain fatty acid-CoA ligase activity|very long-chain fatty acid-CoA ligase activity			endometrium(2)|kidney(2)|large_intestine(11)|liver(1)|lung(15)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	37						AGCAAACCTGGGCCCCCCACT	0.627000													19	26					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128413	83128413	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:83128413C>T	ENST00000329312.4	+	4	734	c.697C>T	c.(697-699)Ccc>Tcc	p.P233S		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	233					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TAGTAATGATCCCATATCAGA	0.328000													18	23					0	0	1	0	0
GK2	2712	broad.mit.edu	37	4	80327935	80327935	+	Missense_Mutation	SNP	G	G	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr4:80327935G>T	ENST00000358842.3	-	1	1437	c.1420C>A	c.(1420-1422)Ctt>Att	p.L474I		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	474					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						TGGGGTTCAAGGCTCCAAACG	0.478000													3	55					0.004672	0.00480361	1	1	0
TUBB8P7	0	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr16:90161902A>G	ENST00000564451.1	+	0	1255				TUBB8P7_ENST00000567960.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													3	40					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													6	35					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22941745	22941745	+	Silent	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:22941745A>G	ENST00000397104.3	-	5	692	c.693T>C	c.(691-693)ttT>ttC	p.F231F	ZNF99_ENST00000596209.1_Silent_p.F322F					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGAAATGGTTAAAAGCTTTGC	0.393000													39	54					0	0	1	0	0
NUFIP2	57532	broad.mit.edu	37	17	27614074	27614074	+	Missense_Mutation	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr17:27614074T>C	ENST00000225388.4	-	2	996	c.938A>G	c.(937-939)aAa>aGa	p.K313R	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	313						nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			ATCAAACTTTTTGCTGCTCAC	0.488000													10	113					0	0	1	0	0
NARFL	64428	broad.mit.edu	37	16	787302	787302	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr16:787302C>T	ENST00000251588.2	-	3	206	c.190G>A	c.(190-192)Gcc>Acc	p.A64T	NARFL_ENST00000540986.1_5'UTR|NARFL_ENST00000568545.1_5'UTR|NARFL_ENST00000301694.5_Missense_Mutation_p.A64T	NM_022493.1	NP_071938.1	Q9H6Q4	NARFL_HUMAN	nuclear prelamin A recognition factor-like	64					iron-sulfur cluster assembly|oxygen homeostasis|regulation of transcription, DNA-dependent|response to hypoxia		4 iron, 4 sulfur cluster binding|metal ion binding			autonomic_ganglia(1)|large_intestine(1)|lung(7)	9		Hepatocellular(780;0.0218)				GAGACCTTGGCCTTCTCCAGC	0.627000													31	50					0	0	1	0	0
KMO	8564	broad.mit.edu	37	1	241731922	241731922	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr1:241731922C>T	ENST00000366559.4	+	10	1243	c.932C>T	c.(931-933)cCg>cTg	p.P311L	KMO_ENST00000366558.3_Missense_Mutation_p.P311L|KMO_ENST00000366557.4_Missense_Mutation_p.P311L	NM_003679.4	NP_003670.2	O15229	KMO_HUMAN	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	311					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GCTATAGTGCCGTTTTTTGGG	0.433000													28	31					0	0	1	0	0
ATG2B	55102	broad.mit.edu	37	14	96795934	96795934	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr14:96795934T>A	ENST00000359933.4	-	12	2661	c.1768A>T	c.(1768-1770)Aga>Tga	p.R590*		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	590										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GATCTTTGTCTTTGTTCATAG	0.323000													3	66					0	0	1	0	0
PKDREJ	10343	broad.mit.edu	37	22	46657680	46657680	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr22:46657680C>T	ENST00000253255.5	-	1	1539	c.1540G>A	c.(1540-1542)Gga>Aga	p.G514R		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	514	REJ.				acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CCATTCCTTCCTGTTACAGTT	0.388000													26	289					0	0	1	0	0
GPER	0	broad.mit.edu	37	7	1131728	1131728	+	Silent	SNP	C	C	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr7:1131728C>A	ENST00000397092.1	+	3	1248	c.364C>A	c.(364-366)Cgg>Agg	p.R122R	GPER_ENST00000397088.3_Silent_p.R122R|GPER_ENST00000297469.3_Silent_p.R122R|C7orf50_ENST00000357429.6_Intron|C7orf50_ENST00000397100.2_Intron|GPER_ENST00000401670.1_Silent_p.R122R|C7orf50_ENST00000488073.1_Intron|C7orf50_ENST00000397098.3_Intron	NM_001039966.1	NP_001035055.1	Q99527	GPER_HUMAN		122						endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	13		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		CCTGCACGAGCGGTACTACGA	0.577000													3	69					0.115264	0.115264	1	1	0
ADRA2A	150	broad.mit.edu	37	10	112839099	112839099	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:112839099C>T	ENST00000280155.2	+	1	2310	c.1345C>T	c.(1345-1347)Cgc>Tgc	p.R449C		NM_000681.3	NP_000672.3	P08913	ADA2A_HUMAN	adrenoceptor alpha 2A	434					actin cytoskeleton organization|activation of MAPK activity by adrenergic receptor signaling pathway|activation of phospholipase C activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cellular component movement|cellular response to hormone stimulus|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|glucose homeostasis|inhibition of adenylate cyclase activity by adrenergic receptor signaling pathway|intestinal absorption|negative regulation of adrenergic receptor signaling pathway|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cAMP biosynthetic process|negative regulation of epinephrine secretion|negative regulation of insulin secretion involved in cellular response to glucose stimulus|negative regulation of lipid catabolic process|negative regulation of norepinephrine secretion|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cytokine production|positive regulation of membrane protein ectodomain proteolysis|positive regulation of potassium ion transport|positive regulation of wound healing|Rho protein signal transduction	basolateral plasma membrane|cytoplasm|integral to plasma membrane|receptor complex	alpha-1B adrenergic receptor binding|alpha-2C adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|heterotrimeric G-protein binding|norepinephrine binding|protein heterodimerization activity|protein homodimerization activity|protein kinase binding|thioesterase binding			breast(1)|cervix(3)|endometrium(6)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(234;0.0735)|Lung NSC(174;0.238)		Epithelial(162;0.000316)|all cancers(201;0.00501)|BRCA - Breast invasive adenocarcinoma(275;0.118)	Amitriptyline(DB00321)|Amphetamine(DB00182)|Apraclonidine(DB00964)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Brimonidine(DB00484)|Clonidine(DB00575)|Debrisoquin(DB04840)|Dexmedetomidine(DB00633)|Dipivefrin(DB00449)|Epinastine(DB00751)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanabenz(DB00629)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Lofexidine(DB04948)|Methyldopa(DB00968)|Mianserin(DB06148)|Mirtazapine(DB00370)|Norepinephrine(DB00368)|Oxymetazoline(DB00935)|Phentolamine(DB00692)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Tizanidine(DB00697)|Trazodone(DB00656)|Yohimbine(DB01392)	CCACGATTTCCGCCGCGCCTT	0.592000													19	88					0	0	1	0	0
RTN4RL1	146760	broad.mit.edu	37	17	1840215	1840215	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr17:1840215A>G	ENST00000331238.5	-	2	919	c.901T>C	c.(901-903)Ttc>Ctc	p.F301L		NM_178568.2	NP_848663.1	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1	301	LRRCT.				axon regeneration	anchored to plasma membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|prostate(2)|skin(1)	11						CAGTTCCGGAAGTCCTCGGCC	0.682000													5	11					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													4	49					0	0	1	0	0
NRSN2	80023	broad.mit.edu	37	20	333951	333951	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr20:333951G>A	ENST00000382291.3	+	4	527	c.287G>A	c.(286-288)gGt>gAt	p.G96D	NRSN2_ENST00000382285.2_Missense_Mutation_p.G96D|NRSN2_ENST00000492242.1_3'UTR	NM_024958.2	NP_079234.1	Q9GZP1	NRSN2_HUMAN	neurensin 2	96						integral to membrane|plasma membrane|transport vesicle				endometrium(1)|large_intestine(2)|lung(4)|urinary_tract(1)	8		all_cancers(10;0.0834)				ATCGGTGAGGGTGAGTTCCTG	0.647000													4	69					0	0	1	0	0
TBR1	10716	broad.mit.edu	37	2	162273034	162273034	+	Missense_Mutation	SNP	C	C	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:162273034C>G	ENST00000389554.3	+	1	430	c.113C>G	c.(112-114)cCc>cGc	p.P38R		NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	38						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						CACGATCATCCCATTATCTCG	0.463000													26	40					0	0	1	0	0
STK36	27148	broad.mit.edu	37	2	219557982	219557982	+	Missense_Mutation	SNP	A	A	G			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:219557982A>G	ENST00000295709.3	+	17	2342	c.2063A>G	c.(2062-2064)aAt>aGt	p.N688S	STK36_ENST00000392105.3_Missense_Mutation_p.N688S|STK36_ENST00000392106.2_Missense_Mutation_p.N688S|STK36_ENST00000440309.1_Missense_Mutation_p.N688S	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	688					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CATTTGGCAAATCAGCTAACT	0.478000													5	46					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24923301	24923301	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr15:24923301C>T	ENST00000329468.2	+	1	2761	c.2287C>T	c.(2287-2289)Cct>Tct	p.P763S		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		TTCCAACCATCCTTTAAATCC	0.572000													63	172					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149549	34149549	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chrX:34149549G>A	ENST00000346193.3	-	1	898	c.847C>T	c.(847-849)Cgg>Tgg	p.R283W		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	283										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTCTTCTCCCGGCCCTCACAA	0.577000													17	25					0	0	1	0	0
ZNF714	148206	broad.mit.edu	37	19	21300392	21300392	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:21300392G>A	ENST00000596143.1	+	5	1247	c.922G>A	c.(922-924)Gga>Aga	p.G308R	ZNF714_ENST00000601416.1_3'UTR|ZNF714_ENST00000596053.1_Intron|ZNF714_ENST00000291770.7_3'UTR	NM_182515.3	NP_872321.2	Q96N38	ZN714_HUMAN	zinc finger protein 714	309					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|urinary_tract(2)	18						AATTCATTCTGGAGAGAAATC	0.328000													13	15					0	0	1	0	0
CLC	1178	broad.mit.edu	37	19	40225051	40225051	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:40225051C>A	ENST00000221804.4	-	3	250	c.175G>T	c.(175-177)Ggt>Tgt	p.G59C		NM_001828.5	NP_001819.2	Q05315	LPPL_HUMAN	Charcot-Leyden crystal galectin	59	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(2)|stomach(1)	12	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		ACACGACGACCAAAGCACACT	0.493000													16	88					9.16793e-09	9.6994e-09	1	1	0
FOXN4	121643	broad.mit.edu	37	12	109719350	109719350	+	Missense_Mutation	SNP	C	C	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr12:109719350C>A	ENST00000299162.5	-	9	1260	c.1156G>T	c.(1156-1158)Gcc>Tcc	p.A386S	FOXN4_ENST00000355216.1_Missense_Mutation_p.A206S	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	386					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						TCCGGCAGGGCGTGCAGTGGC	0.657000													3	11					0.115264	0.115264	1	1	0
PLD1	5337	broad.mit.edu	37	3	171455389	171455389	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr3:171455389G>A	ENST00000356327.5	-	3	291	c.221C>T	c.(220-222)aCg>aTg	p.T74M	PLD1_ENST00000351298.4_Missense_Mutation_p.T74M|PLD1_ENST00000340989.4_Missense_Mutation_p.T74M|PLD1_ENST00000342215.6_Missense_Mutation_p.T74M	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	74					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity	p.T74M(1)		breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GGAGAGATACGTCTGTATATT	0.358000													30	23					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47367799	47367799	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr18:47367799G>A	ENST00000285039.7	-	35	4936	c.4637C>T	c.(4636-4638)aCg>aTg	p.T1546M	MYO5B_ENST00000592688.1_Missense_Mutation_p.T116M|MYO5B_ENST00000324581.6_Missense_Mutation_p.T661M|SCARNA17_ENST00000589499.1_RNA	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1546	Dilute.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		CCAGAATGACGTCATCTCAAA	0.522000													38	101					0	0	1	0	0
KIAA0319	9856	broad.mit.edu	37	6	24559320	24559320	+	Silent	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr6:24559320C>T	ENST00000535378.1	-	18	3270	c.2628G>A	c.(2626-2628)gtG>gtA	p.V876V	KIAA0319_ENST00000430948.2_Silent_p.V840V|KIAA0319_ENST00000378214.3_Silent_p.V885V|KIAA0319_ENST00000543707.1_Silent_p.V885V|KIAA0319_ENST00000537886.1_Silent_p.V885V	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	885					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						GATTTCGGGCCACTTCAGCAG	0.493000													8	21					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70013431	70013431	+	Missense_Mutation	SNP	G	G	A			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:70013431G>A	ENST00000355303.5	+	21	2440	c.2135G>A	c.(2134-2136)cGg>cAg	p.R712Q	ANO1_ENST00000531349.1_Missense_Mutation_p.R421Q|ANO1_ENST00000538023.1_Missense_Mutation_p.R712Q|ANO1_ENST00000398543.2_Missense_Mutation_p.R566Q|ANO1_ENST00000530676.1_Missense_Mutation_p.R566Q	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	712					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						AGGAAACAGCGGTACGAGGTG	0.562000													6	22					0	0	1	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635560	122635560	+	Missense_Mutation	SNP	C	C	T			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr7:122635560C>T	ENST00000249284.2	-	1	194	c.129G>A	c.(127-129)atG>atA	p.M43I		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	43					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TGTCCACAGGCATCAGCCTTC	0.443000													17	33					0	0	1	0	0
SOWAHC	65124	broad.mit.edu	37	2	110373253	110373253	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:110373253delC	ENST00000356454.3	+	1	1343	c.1187delC	c.(1186-1188)gcfs	p.A396fs		NM_023016.3	NP_075392.2	Q53LP3	ANR57_HUMAN	sosondowah ankyrin repeat domain family member C	396																	CTGGTGGGAGCCCTGGACGAG	0.617													29	36	---	---	---	---					
ERCC3	2071	broad.mit.edu	37	2	128030454	128030454	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr2:128030454delA	ENST00000493187.2	-	11	2085	c.1622delT	c.(1621-1623)acfs	p.I541fs	ERCC3_ENST00000285398.2_Frame_Shift_Del_p.I605fs			P19447	ERCC3_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 3	605					cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	31	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		GGATATGAAGATGGTGTTAAT	0.483			"""Mis, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				36	66	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150816	65150816	+	RNA	DEL	A	A	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr7:65150816delA	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCC	0.463													4	9	---	---	---	---					
ADAMTSL1	92949	broad.mit.edu	37	9	18826274	18826274	+	Frame_Shift_Del	DEL	C	C	-	rs80308610		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr9:18826274delC	ENST00000380545.5	+	1	139	c.30delC	c.(28-30)ttfs	p.F11fs	ADAMTSL1_ENST00000380548.4_Intron			Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	0						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TTTTTTTTTTCTTCCTAGGAG	0.488													2	4	---	---	---	---					
TAF1L	138474	broad.mit.edu	37	9	32633529	32633529	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr9:32633529delA	ENST00000242310.4	-	1	2138	c.2049delT	c.(2047-2049)ttfs	p.F683fs	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	683					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GTGTGCGCATAAAAAACAACT	0.453													63	38	---	---	---	---					
TYSND1	219743	broad.mit.edu	37	10	71905929	71905931	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:71905929_71905931delCAG	ENST00000287078.6	-	1	411_413	c.412_414delCTG	c.(412-414)del	p.L138del	TYSND1_ENST00000335494.5_In_Frame_Del_p.L138del	NM_173555.2	NP_775826.2	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1	138					proteolysis	peroxisome	serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(3)|prostate(1)	9						CCGGGCAGCTCAGCAGCAGCAGC	0.739													2	4	---	---	---	---					
FRG2B	441581	broad.mit.edu	37	10	135438960	135438960	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr10:135438960delC	ENST00000443774.1	-	4	532	c.483delG	c.(481-483)agfs	p.R161fs	FRG2B_ENST00000425520.1_Frame_Shift_Del_p.R160fs			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	160						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		GGGCCCGAGACCTATGCCGCT	0.557													7	204	---	---	---	---					
RP13-726E6.2	0	broad.mit.edu	37	11	3552650	3552651	+	RNA	INS	-	-	G	rs34642454		TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:3552650_3552651insG	ENST00000527970.1	-	0	285																											CAGCACCCCATGGGGGGGCCCT	0.500													5	4	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89421732	89421734	+	RNA	DEL	TGT	TGT	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:89421732_89421734delTGT	ENST00000532352.1	+	0	1421							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						GAAATAATTCTGTTGTTTTATCT	0.315													25	65	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738793	102738794	+	RNA	INS	-	-	T	rs35342965	by1000genomes	TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr11:102738793_102738794insT	ENST00000532855.1	-	0	727_728							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TGAGGAACAAGTGGTGCCTAAG	0.416													3	6	---	---	---	---					
LRP1	4035	broad.mit.edu	37	12	57596983	57596986	+	Frame_Shift_Del	DEL	GAGT	GAGT	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr12:57596983_57596986delGAGT	ENST00000243077.3	+	69	11197_11200	c.10731_10734delGAGT	c.(10729-10734)gafs	p.ES3577fs		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3577	LDL-receptor class A 27.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTGCTCCGAGAGTGAGTTCTCCT	0.676													4	7	---	---	---	---					
GTF3C1	2975	broad.mit.edu	37	16	27503732	27503733	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr16:27503732_27503733delAT	ENST00000356183.4	-	19	3092_3093	c.3077_3078delAT	c.(3076-3078)tfs	p.Y1026fs	GTF3C1_ENST00000561623.1_Frame_Shift_Del_p.Y1026fs	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1026						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						AGTTCAGGACATAGAGGCGCCT	0.540													31	57	---	---	---	---					
RP11-178C3.2	0	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													2	4	---	---	---	---					
NDUFA7	4701	broad.mit.edu	37	19	8381422	8381424	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-DU-A6S8-01A-12D-A32B-08	TCGA-DU-A6S8-10A-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c643556f-5d54-4821-b2c1-af7b5ff789d6	e33db528-eb1b-4812-9956-03280bb3bd0c	g.chr19:8381422_8381424delATG	ENST00000301457.2	-	3	244_246	c.207_209delCAT	c.(205-210)atg>at	p.IM69del	NDUFA7_ENST00000598884.1_In_Frame_Del_p.IM69del	NM_005001.3	NP_004992.2	O95182	NDUA7_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa	69					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			NS(1)|central_nervous_system(1)|lung(2)|ovary(1)	5					NADH(DB00157)	CTGCGACGACATGATGATGGAAG	0.611													29	68	---	---	---	---