Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RREB1	6239	broad.mit.edu	37	6	7229727	7229727	+	Silent	SNP	C	C	T	rs138539147		TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr6:7229727C>T	ENST00000379938.2	+	10	1932	c.1395C>T	c.(1393-1395)atC>atT	p.I465I	RREB1_ENST00000349384.6_Silent_p.I465I|RREB1_ENST00000334984.6_Silent_p.I465I|RREB1_ENST00000379933.3_Silent_p.I465I	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	465					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AGTCGGCCATCGAGCTGGCAG	0.602000													26	124					0	0	1	0	0
NKX2-1	7080	broad.mit.edu	37	14	36987036	36987036	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr14:36987036G>A	ENST00000518149.1	-	3	1168	c.563C>T	c.(562-564)gCg>gTg	p.A188V	NKX2-1_ENST00000498187.2_Missense_Mutation_p.A188V|NKX2-1_ENST00000522719.2_Missense_Mutation_p.A188V|RP11-896J10.3_ENST00000521945.1_RNA|NKX2-1_ENST00000354822.5_Missense_Mutation_p.A218V			P43699	NKX21_HUMAN	NK2 homeobox 1	188					epithelial tube branching involved in lung morphogenesis|globus pallidus development|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|thyroid gland development		protein binding|transcription regulatory region DNA binding			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	7	all_cancers(3;4.47e-51)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)|Breast(36;0.165)		Lung(8;1.8e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.014)|all cancers(34;0.0366)|LUSC - Lung squamous cell carcinoma(13;0.132)	GBM - Glioblastoma multiforme(112;0.0171)		GCGCTCCGGCGCCGACAGGTA	0.647000			A		NSCLC								5	19					0	0	1	0	0
C9orf114	51490	broad.mit.edu	37	9	131588889	131588889	+	Missense_Mutation	SNP	T	T	G			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr9:131588889T>G	ENST00000361256.5	-	5	428	c.388A>C	c.(388-390)Aca>Cca	p.T130P		NM_016390.3	NP_057474.2	Q5T280	CI114_HUMAN	chromosome 9 open reading frame 114	130			T -> R (in dbSNP:rs6478854).							kidney(2)|large_intestine(4)|ovary(1)	7						CCAACTCCTGTGAATTCCCCC	0.592000													5	21					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47422168	47422168	+	Missense_Mutation	SNP	T	T	G			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:47422168T>G	ENST00000404338.3	+	1	236	c.236T>G	c.(235-237)gTt>gGt	p.V79G		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	79					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										TGGGGAGAAGTTAGCCGCTCC	0.493000													6	49					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33477781	33477781	+	Silent	SNP	T	T	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr2:33477781T>C	ENST00000404816.2	+	11	2390	c.2037T>C	c.(2035-2037)tgT>tgC	p.C679C	LTBP1_ENST00000407925.1_Silent_p.C353C|LTBP1_ENST00000390003.4_Silent_p.C353C|LTBP1_ENST00000418533.2_Silent_p.C353C|LTBP1_ENST00000354476.3_Silent_p.C679C|LTBP1_ENST00000404525.1_Silent_p.C353C|LTBP1_ENST00000402934.1_Silent_p.C353C			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	679	TB 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AAGGGCCCTGTTACCGACTTG	0.512000													4	107					0	0	1	0	0
D2HGDH	728294	broad.mit.edu	37	2	242684241	242684241	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr2:242684241G>A	ENST00000321264.4	+	6	1011	c.802G>A	c.(802-804)Gtg>Atg	p.V268M	D2HGDH_ENST00000537090.1_Missense_Mutation_p.V268M|D2HGDH_ENST00000403782.1_Missense_Mutation_p.V134M|D2HGDH_ENST00000342518.6_Missense_Mutation_p.V268M	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	268	FAD-binding PCMH-type.				2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CATCACCACGGTGTCCATCTT	0.597000													27	24					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810517	7810517	+	Missense_Mutation	SNP	T	T	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:7810517T>A	ENST00000315599.7	-	4	657	c.635A>T	c.(634-636)cAg>cTg	p.Q212L	CD209_ENST00000204801.8_Missense_Mutation_p.Q168L|CD209_ENST00000593660.1_Intron|CD209_ENST00000593821.1_Intron|CD209_ENST00000602261.1_Intron|CD209_ENST00000354397.6_Missense_Mutation_p.Q212L|CD209_ENST00000394161.5_Intron|CD209_ENST00000301357.8_Intron|CD209_ENST00000315591.8_Missense_Mutation_p.Q188L|CD209_ENST00000601951.1_Missense_Mutation_p.Q188L|CD209_ENST00000394173.4_Intron|CD209_ENST00000601256.1_Missense_Mutation_p.Q188L	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	212	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding	p.Q212L(2)		endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GATCTCCTGCTGCTTAGATTT	0.562000													4	109					0	0	1	0	0
APBA1	320	broad.mit.edu	37	9	72131193	72131193	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr9:72131193C>T	ENST00000265381.4	-	2	1156	c.934G>A	c.(934-936)Gac>Aac	p.D312N		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	312	Munc-18-1 binding.|Pro-rich.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						ccggggctgtcggggcgaccc	0.766000													3	11					0	0	1	0	0
SMC1A	8243	broad.mit.edu	37	X	53432803	53432803	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chrX:53432803G>A	ENST00000322213.4	-	10	1758	c.1631C>T	c.(1630-1632)gCc>gTc	p.A544V	SMC1A_ENST00000375340.6_Missense_Mutation_p.A310V	NM_006306.2	NP_006297.2	Q14683	SMC1A_HUMAN	structural maintenance of chromosomes 1A	544	Flexible hinge.				cell cycle checkpoint|cell division|DNA repair|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic sister chromatid cohesion|mitotic spindle organization|negative regulation of DNA endoreduplication|nuclear mRNA splicing, via spliceosome|response to radiation|signal transduction in response to DNA damage	cohesin core heterodimer|condensed chromosome kinetochore|condensed nuclear chromosome|cytoplasm|meiotic cohesin complex|nucleoplasm	ATP binding|chromatin binding|microtubule motor activity|protein heterodimerization activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(8)|ovary(5)|upper_aerodigestive_tract(2)	49						CACAATAATGGCATCCATGTT	0.502000													22	6					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43763054	43763054	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:43763054G>A	ENST00000418820.2	-	3	762	c.664C>T	c.(664-666)Cga>Tga	p.R222*	PSG9_ENST00000244293.7_Intron|PSG9_ENST00000270077.3_Nonsense_Mutation_p.R315*|PSG9_ENST00000596730.1_Intron|PSG9_ENST00000443718.3_Nonsense_Mutation_p.R222*|PSG9_ENST00000291752.5_Intron|PSG9_ENST00000593948.1_Intron			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	222	Ig-like C2-type 1.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				CCACCATATCGGTCCCGTATT	0.498000													16	34					0	0	1	0	0
IGHV3-20	0	broad.mit.edu	37	14	106668030	106668030	+	RNA	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr14:106668030C>T	ENST00000390606.2	-	0	65																											AGCCCAAACTCCATGGCGAGT	0.507000													34	130					0	0	1	0	0
AVPR1A	0	broad.mit.edu	37	12	63543965	63543965	+	Missense_Mutation	SNP	T	T	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr12:63543965T>C	ENST00000299178.2	-	1	757	c.652A>G	c.(652-654)Acc>Gcc	p.T218A		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	218					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	GTCATCCAGGTCACGTAGGCA	0.592000													56	95					0	0	1	0	0
CEP350	9857	broad.mit.edu	37	1	179959716	179959716	+	Missense_Mutation	SNP	G	G	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:179959716G>C	ENST00000367607.3	+	4	613	c.195G>C	c.(193-195)aaG>aaC	p.K65N		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	65						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TGGATACCAAGAAGTCTTCTA	0.313000													6	12					0	0	1	0	0
TMEM45B	120224	broad.mit.edu	37	11	129725675	129725675	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr11:129725675C>T	ENST00000281441.3	+	4	546	c.458C>T	c.(457-459)gCt>gTt	p.A153V	TMEM45B_ENST00000524567.1_Missense_Mutation_p.A153V	NM_138788.3	NP_620143.1	Q96B21	TM45B_HUMAN	transmembrane protein 45B	153						integral to membrane				endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|stomach(1)	12	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.012)|Lung(977;0.179)|LUSC - Lung squamous cell carcinoma(976;0.189)		CTGCTGTATGCTCTGTTCGGA	0.537000													60	65					0	0	1	0	0
PRMT5	10419	broad.mit.edu	37	14	23393534	23393534	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr14:23393534C>T	ENST00000324366.8	-	11	1367	c.1144G>A	c.(1144-1146)Gcc>Acc	p.A382T	PRMT5_ENST00000397440.4_Missense_Mutation_p.A211T|PRMT5_ENST00000397441.2_Missense_Mutation_p.A365T|PRMT5_ENST00000553897.1_Missense_Mutation_p.A338T|PRMT5-AS1_ENST00000599580.1_RNA|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5-AS1_ENST00000590290.1_RNA|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000538452.1_Missense_Mutation_p.A276T|PRMT5_ENST00000216350.8_Missense_Mutation_p.A321T	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	382					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		CGCCGGTCGGCCTGCTTGGCT	0.557000													25	82					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1049302	1049302	+	Silent	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:1049302C>T	ENST00000263094.6	+	18	2649	c.2418C>T	c.(2416-2418)ggC>ggT	p.G806G	ABCA7_ENST00000435683.2_Silent_p.G668G|ABCA7_ENST00000433129.1_Silent_p.G806G	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	806					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGTCCTGGCGTCTCCGTTC	0.667000													44	75					0	0	1	0	0
INSL4	3641	broad.mit.edu	37	9	5231539	5231539	+	Missense_Mutation	SNP	C	C	T	rs142741438	byFrequency	TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr9:5231539C>T	ENST00000239316.4	+	1	121	c.16C>T	c.(16-18)Cgg>Tgg	p.R6W		NM_002195.1	NP_002186.1	Q14641	INSL4_HUMAN	insulin-like 4 (placenta)	6					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding			endometrium(2)|lung(2)|skin(1)|urinary_tract(1)	6	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		CAGCCTGTTCCGGTCCTATCT	0.542000													9	25					0	0	1	0	0
CENPL	91687	broad.mit.edu	37	1	173776588	173776588	+	Silent	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:173776588G>A	ENST00000356198.2	-	4	522	c.237C>T	c.(235-237)ccC>ccT	p.P79P	CENPL_ENST00000345664.6_Silent_p.P79P|CENPL_ENST00000367710.3_Silent_p.P79P	NM_001127181.2	NP_001120653.1	Q8N0S6	CENPL_HUMAN	centromere protein L	79					mitotic prometaphase	chromosome, centromeric region|cytosol|nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(3)	11						ATTTATATAAGGGAGTTAAAC	0.333000													11	69					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11311002	11311002	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:11311002G>A	ENST00000294618.7	-	47	6094	c.6083C>T	c.(6082-6084)cCc>cTc	p.P2028L	DOCK6_ENST00000586702.1_5'UTR|DOCK6_ENST00000319867.7_Missense_Mutation_p.P1367L	NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	2028					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						GGGTGGGGTGGGTGCCATCAG	0.652000													2	3					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								37	46					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190554618	190554618	+	Missense_Mutation	SNP	A	A	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr2:190554618A>T	ENST00000520309.1	+	3	1055	c.967A>T	c.(967-969)Att>Ttt	p.I323F	ANKAR_ENST00000461516.1_3'UTR|ANKAR_ENST00000313581.4_Missense_Mutation_p.I323F|ANKAR_ENST00000431575.2_Missense_Mutation_p.I252F|ANKAR_ENST00000438402.2_Missense_Mutation_p.I323F|ANKAR_ENST00000281412.6_Missense_Mutation_p.I87F	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	323						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ATGTTTTCTGATTCCATTTCT	0.284000													20	73					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179456193	179456193	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr2:179456193C>T	ENST00000589042.1	-	304	60483	c.60259G>A	c.(60259-60261)Ggt>Agt	p.G20087S	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G17519S|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.G11214S|TTN_ENST00000591111.1_Missense_Mutation_p.G18446S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G11022S|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G11147S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18446	Fibronectin type-III 45.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCACAAGACCTTCAATTAAT	0.378000													69	107					0	0	1	0	0
ATP2A1	487	broad.mit.edu	37	16	28900194	28900194	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr16:28900194G>A	ENST00000395503.4	+	9	1199	c.1015G>A	c.(1015-1017)Gta>Ata	p.V339I	ATP2A1_ENST00000536376.1_Missense_Mutation_p.V214I|ATP2A1_ENST00000357084.3_Missense_Mutation_p.V339I	NM_004320.4	NP_004311.1	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	339					apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	38						CTTGCCCTCCGTAGAGACCCT	0.587000													5	172					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245862232	245862232	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:245862232G>A	ENST00000366518.4	+	11	5032	c.4928G>A	c.(4927-4929)cGc>cAc	p.R1643H	KIF26B_ENST00000407071.2_Missense_Mutation_p.R2024H			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	2024					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R2024H(1)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CTGGAACACCGCCAGCAGAGG	0.572000													18	31					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43161369	43161369	+	Silent	SNP	T	T	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr5:43161369T>C	ENST00000509634.1	+	4	846	c.390T>C	c.(388-390)gcT>gcC	p.A130A	ZNF131_ENST00000505606.2_Silent_p.A130A|ZNF131_ENST00000399534.1_Silent_p.A130A|ZNF131_ENST00000509931.1_Intron|ZNF131_ENST00000509156.1_Silent_p.A130A|ZNF131_ENST00000306938.4_Silent_p.A130A			P52739	ZN131_HUMAN	zinc finger protein 131	130						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						AAAACTCAGCTCCCTTAGAGG	0.358000													30	39					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62892257	62892257	+	Silent	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr17:62892257G>A	ENST00000584306.1	-	3	1649	c.1119C>T	c.(1117-1119)gtC>gtT	p.V373V	RP11-927P21.1_ENST00000584959.1_RNA|LRRC37A3_ENST00000400877.3_Intron|LRRC37A3_ENST00000319651.5_Silent_p.V373V|RP11-927P21.1_ENST00000584131.1_RNA|RP11-927P21.1_ENST00000577938.1_RNA|LRRC37A3_ENST00000339474.5_Intron	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	373						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GAGAAGATTCGACCTCCCTAG	0.522000													8	262					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142626594	142626594	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr7:142626594C>T	ENST00000265310.1	-	4	764	c.416G>A	c.(415-417)cGc>cAc	p.R139H	TRPV5_ENST00000442623.1_Missense_Mutation_p.R139H	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	139					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					ACTGGCCCTGCGGGTGAGCAG	0.602000													4	68					0	0	1	0	0
C10orf54	64115	broad.mit.edu	37	10	73521533	73521533	+	Silent	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr10:73521533G>A	ENST00000394957.3	-	2	391	c.333C>T	c.(331-333)caC>caT	p.H111H	CDH23_ENST00000224721.6_Intron|C10orf54_ENST00000481568.1_5'UTR	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	111	Ig-like.					integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						GAGCCAGGTCGTGGCTGGTGT	0.652000													24	21					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176853605	176853605	+	Silent	SNP	G	G	A	rs144434019		TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:176853605G>A	ENST00000367654.2	-	19	3133	c.3120C>T	c.(3118-3120)caC>caT	p.H1040H	ASTN1_ENST00000424564.2_Silent_p.H1032H|ASTN1_ENST00000367657.3_Silent_p.H1032H|ASTN1_ENST00000361833.2_Silent_p.H1032H			O14525	ASTN1_HUMAN	astrotactin 1	1040	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TGCTGGGCTCGTGAACCGTGG	0.522000													3	70					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27204221	27204221	+	Missense_Mutation	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr3:27204221G>A	ENST00000429845.2	-	31	3202	c.2840C>T	c.(2839-2841)aCt>aTt	p.T947I	NEK10_ENST00000357467.2_Missense_Mutation_p.T344I|NEK10_ENST00000498182.1_5'UTR|NEK10_ENST00000383770.3_Missense_Mutation_p.T259I|NEK10_ENST00000295720.6_Missense_Mutation_p.T259I|NEK10_ENST00000383771.4_Missense_Mutation_p.T259I			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	947							ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TGTTCCTCCAGTGAAGTCCCT	0.353000													10	43					0	0	1	0	0
DNASE2	1777	broad.mit.edu	37	19	12991928	12991928	+	Missense_Mutation	SNP	C	C	G			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:12991928C>G	ENST00000222219.3	-	2	217	c.125G>C	c.(124-126)gGg>gCg	p.G42A	DNASE2_ENST00000538460.1_Missense_Mutation_p.G42A|CTD-2265O21.7_ENST00000592400.1_RNA	NM_001375.2	NP_001366.1	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal	42					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)	7						CGCCGCCTCCCCGGACCCTCT	0.637000													7	60					0	0	1	0	0
ATP1B4	23439	broad.mit.edu	37	X	119496054	119496054	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chrX:119496054C>T	ENST00000218008.3	+	1	88	c.31C>T	c.(31-33)Cca>Tca	p.P11S	ATP1B4_ENST00000539306.1_Missense_Mutation_p.P11S|ATP1B4_ENST00000361319.3_Missense_Mutation_p.P11S	NM_001142447.2	NP_001135919.1	Q9UN42	AT1B4_HUMAN	ATPase, Na+/K+ transporting, beta 4 polypeptide	11					ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	33						CAGAAGGGCTCCATCCTTTCC	0.542000													5	111					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78430654	78430654	+	Splice_Site	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:78430654C>T	ENST00000370767.1	-	9	724		c.e9-1		FUBP1_ENST00000370768.2_Splice_Site|FUBP1_ENST00000436586.2_Splice_Site			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1						transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						CAGCCCGTTCCTGTTACAATC	0.368000			"""F, N"""		oligodendroglioma								57	15					0	0	1	0	0
ZCRB1	85437	broad.mit.edu	37	12	42711593	42711593	+	Missense_Mutation	SNP	T	T	G			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr12:42711593T>G	ENST00000266529.3	-	4	404	c.221A>C	c.(220-222)aAa>aCa	p.K74T	PPHLN1_ENST00000549190.1_Intron|ZCRB1_ENST00000552673.1_Missense_Mutation_p.K33T	NM_033114.3	NP_149105.3	Q8TBF4	ZCRB1_HUMAN	zinc finger CCHC-type and RNA binding motif 1	74	RRM.				mRNA processing	nucleoplasm|U12-type spliceosomal complex	nucleotide binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|skin(2)	8	all_cancers(12;0.000348)|Breast(8;0.221)	Lung NSC(34;0.123)		GBM - Glioblastoma multiforme(48;0.0689)		GCTTACCTGTTTGTTGTTTAT	0.388000													4	73					0	0	1	0	0
CYP11A1	1583	broad.mit.edu	37	15	74630911	74630911	+	Splice_Site	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr15:74630911C>T	ENST00000358632.4	-	8	1656		c.e8+1		CYP11A1_ENST00000268053.6_Splice_Site|CYP11A1_ENST00000419019.2_Splice_Site	NM_001099773.1	NP_001093243.1	P05108	CP11A_HUMAN	cytochrome P450, family 11, subfamily A, polypeptide 1						C21-steroid hormone biosynthetic process|cholesterol metabolic process|vitamin D metabolic process|xenobiotic metabolic process	mitochondrial matrix	cholesterol monooxygenase (side-chain-cleaving) activity|electron carrier activity|heme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20					Aminoglutethimide(DB00357)|Cholecalciferol(DB00169)|Cimetidine(DB00501)|Clotrimazole(DB00257)|Digitoxin(DB01396)|Digoxin(DB00390)|Medroxyprogesterone(DB00603)|Ouabain(DB01092)|Progesterone(DB00396)|Testosterone(DB00624)|Trilostane(DB01108)	GCTTGACTCACATTGATGAGG	0.572000													25	31					0	0	1	0	0
SLC38A1	81539	broad.mit.edu	37	12	46602870	46602870	+	Missense_Mutation	SNP	T	T	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr12:46602870T>C	ENST00000398637.5	-	6	1049	c.355A>G	c.(355-357)Ata>Gta	p.I119V	SLC38A1_ENST00000546893.1_Missense_Mutation_p.I119V|SLC38A1_ENST00000439706.1_Missense_Mutation_p.I119V|SLC38A1_ENST00000549633.1_5'UTR|SLC38A1_ENST00000549049.1_Missense_Mutation_p.I119V|SLC38A1_ENST00000552197.1_Missense_Mutation_p.I119V	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	119					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			AGGAGGTTTATTGAATATATA	0.313000													11	62					0	0	1	0	0
LTK	4058	broad.mit.edu	37	15	41801323	41801323	+	Silent	SNP	G	G	A			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr15:41801323G>A	ENST00000263800.6	-	8	1098	c.1002C>T	c.(1000-1002)ggC>ggT	p.G334G	LTK_ENST00000453182.2_Silent_p.G273G|LTK_ENST00000355166.5_Silent_p.G273G|LTK_ENST00000561619.1_Silent_p.G16G	NM_002344.5	NP_002335.2	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase	334					apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(16)|skin(3)|urinary_tract(1)	26		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		CTGAAGCGTCGCCCCCTGGAA	0.557000										TSP Lung(18;0.14)			8	27					0	0	1	0	0
CLSPN	63967	broad.mit.edu	37	1	36230093	36230093	+	Missense_Mutation	SNP	A	A	G			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:36230093A>G	ENST00000251195.5	-	3	452	c.356T>C	c.(355-357)tTg>tCg	p.L119S	CLSPN_ENST00000520551.1_Missense_Mutation_p.L119S|CLSPN_ENST00000373220.3_Missense_Mutation_p.L119S|CLSPN_ENST00000318121.3_Missense_Mutation_p.L119S			Q9HAW4	CLSPN_HUMAN	claspin	119					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTCCTGATACAAAGACTTTTC	0.363000													19	28					0	0	1	0	0
AMZ2P1	0	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													5	114					0	0	1	0	0
ARL6IP6	151188	broad.mit.edu	37	2	153575515	153575515	+	Missense_Mutation	SNP	C	C	G			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr2:153575515C>G	ENST00000326446.5	+	1	1088	c.377C>G	c.(376-378)gCc>gGc	p.A126G		NM_152522.5	NP_689735.1	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting protein 6	126						integral to membrane				kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	5						TTCCTCCTCGCCATCGCCTAC	0.602000													7	91					0	0	1	0	0
APOBEC3B	9582	broad.mit.edu	37	22	39382395	39382395	+	Missense_Mutation	SNP	C	C	T			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr22:39382395C>T	ENST00000402182.3	+	4	602	c.547C>T	c.(547-549)Cgc>Tgc	p.R183C	APOBEC3B_ENST00000333467.3_Missense_Mutation_p.R183C|APOBEC3B_ENST00000407298.3_Missense_Mutation_p.R183C			Q9UH17	ABC3B_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B	183					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|RNA binding|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	13	Melanoma(58;0.04)					ATTCCTGCACCGCACGCTAAA	0.498000													23	119					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059508	152059508	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr1:152059508delT	ENST00000368806.1	-	3	714	c.650delA	c.(649-651)agfs	p.K217fs		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	217							calcium ion binding	p.K217M(1)		breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			ACTGCTGGTCTTTTTTGATCC	0.448													20	33	---	---	---	---					
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr4:147560457_147560458insGGC	ENST00000281321.3	+	1	413_414	c.165_166insGGC	c.(163-168)gggcgg>ggGGCgcgg	p.55_56GR>GAR	AC093887.1_ENST00000584185.1_RNA	NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	55	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.762													2	4	---	---	---	---					
TREML2	79865	broad.mit.edu	37	6	41168714	41168716	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr6:41168714_41168716delCAG	ENST00000483722.1	-	1	216_218	c.31_33delCTG	c.(31-33)del	p.L11del		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	11					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCTGTGGCCACAGCAGCAGCAGC	0.631													7	36	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118387360	118387360	+	RNA	DEL	G	G	-			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr10:118387360delG	ENST00000537242.1	+	0	578				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GCAGGAGGCTGGGGGGCCGCG	0.736													2	4	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102745470	102745473	+	RNA	DEL	CAAA	CAAA	-	rs28360358		TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr11:102745470_102745473delCAAA	ENST00000532855.1	-	0	199							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TACGTAAaagcaaacaaacaaaca	0.324													3	3	---	---	---	---					
AC022596.6	0	broad.mit.edu	37	17	16723088	16723092	+	RNA	DEL	TTTTG	TTTTG	-			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr17:16723088_16723092delTTTTG	ENST00000417510.1	-	0	871																											ttttttttttttttgacagggtcta	0.493													2	4	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42794819	42794820	+	Frame_Shift_Ins	INS	-	-	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:42794819_42794820insC	ENST00000572681.2	+	11	4694_4695	c.4626_4627insC	c.(4624-4629)ctccccfs	p.LP1542fs	CIC_ENST00000575354.2_Frame_Shift_Ins_p.LP633fs|CIC_ENST00000160740.3_Frame_Shift_Ins_p.LP633fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	633	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				CACTGGTGCTGCCCCCAAACAA	0.688			"""Mis, F, S"""		oligodendroglioma								10	31	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42796882	42796883	+	Frame_Shift_Ins	INS	-	-	C			TCGA-E1-A7YO-01A-11D-A34A-08	TCGA-E1-A7YO-10A-01D-A34A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9f873874-9d78-4712-a6e6-c2c13e15016c	4093478e-c54d-4591-8b4a-61929343c9c5	g.chr19:42796882_42796883insC	ENST00000572681.2	+	15	6132_6133	c.6064_6065insC	c.(6064-6066)cccfs	p.P2022fs	CIC_ENST00000575354.2_Frame_Shift_Ins_p.P1114fs|CIC_ENST00000160740.3_Frame_Shift_Ins_p.P1113fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding	p.S1117fs*34(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GCCATCCCAGGCCCCCCCAAGC	0.683			"""Mis, F, S"""		oligodendroglioma								10	43	---	---	---	---