Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CDR2	1039	broad.mit.edu	37	16	22361098	22361098	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr16:22361098C>T	ENST00000268383.2	-	3	572	c.265G>A	c.(265-267)Gtc>Atc	p.V89I		NM_001802.1	NP_001793.1	Q01850	CDR2_HUMAN	cerebellar degeneration-related protein 2, 62kDa	89						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(3)|skin(1)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(48;0.0188)		CTTGCTGTGACGTCTAATTGT	0.423000													17	219					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214818125	214818125	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr1:214818125A>T	ENST00000366955.3	+	13	5380	c.5212A>T	c.(5212-5214)Aaa>Taa	p.K1738*		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1834					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AGGGGAAGATAAAACCCAGGG	0.448000													21	32					0	0	1	0	0
UTP23	84294	broad.mit.edu	37	8	117778967	117778967	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr8:117778967G>A	ENST00000309822.2	+	1	226	c.125G>A	c.(124-126)cGc>cAc	p.R42H	UTP23_ENST00000357148.3_Missense_Mutation_p.R42H|UTP23_ENST00000517820.1_Missense_Mutation_p.R42H	NM_032334.2	NP_115710.2	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component, homolog (yeast)	42					rRNA processing	nucleolus				breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	12						CTGCGGGGCCGCATCCAGCTG	0.677000											OREG0018934	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	21					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													3	55					0	0	1	0	0
MT4	84560	broad.mit.edu	37	16	56602775	56602775	+	Silent	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr16:56602775G>A	ENST00000219162.3	+	3	200	c.120G>A	c.(118-120)ccG>ccA	p.P40P		NM_032935.2	NP_116324.1	P47944	MT4_HUMAN	metallothionein 4	40						cytoplasm	copper ion binding|zinc ion binding			ovary(1)|upper_aerodigestive_tract(1)	2						GCTGCCCCCCGGGCTGTGCCA	0.607000													104	134					0	0	1	0	0
CDK11B	984	broad.mit.edu	37	1	1573136	1573136	+	Silent	SNP	G	G	A	rs17434073		TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr1:1573136G>A	ENST00000407249.3	-	14	1460	c.1461C>T	c.(1459-1461)atC>atT	p.I487I	CDK11B_ENST00000340677.5_Silent_p.I474I|CDK11B_ENST00000341832.6_Silent_p.I440I|CDK11B_ENST00000317673.7_Silent_p.I485I			P21127	CD11B_HUMAN	cyclin-dependent kinase 11B	497	Protein kinase.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			endometrium(2)|large_intestine(3)|lung(4)|skin(1)|stomach(2)	12						TAACGGTGACGATGTTGGGAT	0.617000													4	186					0	0	1	0	0
PDZK1	5174	broad.mit.edu	37	1	145761247	145761247	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr1:145761247G>A	ENST00000344770.2	+	7	1133	c.1060G>A	c.(1060-1062)Gct>Act	p.A354T	PDZK1_ENST00000451928.2_Missense_Mutation_p.A243T|PDZK1_ENST00000417171.1_Missense_Mutation_p.A354T	NM_002614.4	NP_002605.2	Q5T2W1	NHRF3_HUMAN	PDZ domain containing 1	354					carnitine transport|cell proliferation|drug transport|positive regulation of ion transmembrane transport	brush border membrane|cytoplasm	PDZ domain binding|transporter activity	p.A354T(1)		NS(1)|endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	7	all_hematologic(18;0.00473)|Acute lymphoblastic leukemia(18;0.0786)		KIRC - Kidney renal clear cell carcinoma(6;0.0764)|Kidney(552;0.118)|Colorectal(543;0.229)			GGAGGCTCCAGCTCCTACTCC	0.428000													38	43					0	0	1	0	0
KLHL8	57563	broad.mit.edu	37	4	88106791	88106791	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr4:88106791T>C	ENST00000273963.5	-	3	718	c.377A>G	c.(376-378)tAt>tGt	p.Y126C	KLHL8_ENST00000512111.1_Missense_Mutation_p.Y126C|KLHL8_ENST00000498875.2_Intron|KLHL8_ENST00000545252.1_Intron|KLHL8_ENST00000425278.2_Intron	NM_020803.3	NP_065854.3	Q9P2G9	KLHL8_HUMAN	kelch-like family member 8	126	BTB.									breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		CCGTGAAGAATAGACAAACTT	0.423000													35	46					0	0	1	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													5	62					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	55					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664186	22664186	+	RNA	SNP	A	A	G			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr22:22664186A>G	ENST00000426066.1	+	0	709					NR_027293.1																						CAGATCAAGAAAGCACTCTGA	0.498000													3	73					0	0	1	0	0
CPSF1	29894	broad.mit.edu	37	8	145626338	145626338	+	Silent	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr8:145626338G>A	ENST00000349769.3	-	6	613	c.519C>T	c.(517-519)caC>caT	p.H173H		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	173					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CGAGCCCCTCGTGCTCCTCAG	0.721000													9	13					0	0	1	0	0
DISP1	84976	broad.mit.edu	37	1	223179138	223179138	+	Missense_Mutation	SNP	T	T	G			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr1:223179138T>G	ENST00000284476.6	+	8	4563	c.4399T>G	c.(4399-4401)Tta>Gta	p.L1467V		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	1467					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		ATTTAATCATTTAATGGGGGA	0.433000													20	40					0	0	1	0	0
FRMD6	122786	broad.mit.edu	37	14	52188776	52188776	+	Silent	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr14:52188776G>A	ENST00000395718.2	+	12	1731	c.1446G>A	c.(1444-1446)tcG>tcA	p.S482S	FRMD6_ENST00000553556.1_Silent_p.S132S|FRMD6_ENST00000554167.1_Silent_p.S413S|FRMD6_ENST00000344768.5_Silent_p.S490S|FRMD6_ENST00000356218.4_Silent_p.S482S	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	490						cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					TGCTCATGTCGCGGAAGCTGA	0.483000													41	35					0	0	1	0	0
KIFC3	3801	broad.mit.edu	37	16	57798074	57798074	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr16:57798074C>T	ENST00000379655.4	-	12	1855	c.1598G>A	c.(1597-1599)gGc>gAc	p.G533D	KIFC3_ENST00000540079.2_Missense_Mutation_p.G431D|KIFC3_ENST00000539578.1_Missense_Mutation_p.G475D|KIFC3_ENST00000562903.1_Missense_Mutation_p.G394D|KIFC3_ENST00000465878.2_Missense_Mutation_p.G394D|KIFC3_ENST00000543930.1_Missense_Mutation_p.G391D|KIFC3_ENST00000445690.2_Missense_Mutation_p.G533D|KIFC3_ENST00000541240.1_Missense_Mutation_p.G555D|KIFC3_ENST00000421376.2_Missense_Mutation_p.G394D	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	533	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				GTACGTCTTGCCGGCGCCCGT	0.597000													3	49					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19439194	19439194	+	Silent	SNP	G	G	A	rs148095267	byFrequency	TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr1:19439194G>A	ENST00000375267.2	-	78	11628	c.11625C>T	c.(11623-11625)tgC>tgT	p.C3875C	UBR4_ENST00000375254.3_Silent_p.C3875C|UBR4_ENST00000375217.2_Silent_p.C3868C|UBR4_ENST00000375226.2_Silent_p.C3851C|UBR4_ENST00000375218.3_3'UTR			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3875					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGCCGAGGCGCAGCCATAGC	0.612000													8	172					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115964540	115964540	+	Silent	SNP	T	T	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr10:115964540T>C	ENST00000251864.2	+	10	1338	c.1185T>C	c.(1183-1185)tgT>tgC	p.C395C	TDRD1_ENST00000369281.2_Silent_p.C395C|TDRD1_ENST00000369280.1_Silent_p.C395C|TDRD1_ENST00000369282.1_Silent_p.C395C|TDRD1_ENST00000422662.1_Silent_p.C56C	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	395					DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		GCAGTGATTGTATCAAAGCTA	0.398000													25	10					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	72					0	0	1	0	0
AAGAB	79719	broad.mit.edu	37	15	67529108	67529108	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr15:67529108C>T	ENST00000261880.5	-	2	228	c.124G>A	c.(124-126)Gtg>Atg	p.V42M	AAGAB_ENST00000542650.1_De_novo_Start_InFrame|AAGAB_ENST00000561452.1_De_novo_Start_InFrame	NM_001271885.1|NM_001271886.1|NM_024666.3	NP_001258814.1|NP_001258815.1|NP_078942.3	Q6PD74	AAGAB_HUMAN	alpha- and gamma-adaptin binding protein	42					protein transport	cytoplasm				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9						TAAAATCTCACAGCATCATTG	0.343000													15	30					0	0	1	0	0
ZNF485	220992	broad.mit.edu	37	10	44112341	44112341	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr10:44112341A>G	ENST00000361807.3	+	5	1044	c.850A>G	c.(850-852)Act>Gct	p.T284A	ZNF485_ENST00000374435.3_Missense_Mutation_p.T284A|ZNF485_ENST00000374437.2_Missense_Mutation_p.T193A	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	284					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						GGATAATTCAACTGTGTTGGA	0.403000													22	37					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								33	64					0	0	1	0	0
HELB	92797	broad.mit.edu	37	12	66703572	66703572	+	Silent	SNP	T	T	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr12:66703572T>A	ENST00000247815.4	+	4	923	c.864T>A	c.(862-864)acT>acA	p.T288T		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	288					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AGCTGATGACTGATTTGGAGA	0.383000													49	61					0	0	1	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128812	45128812	+	RNA	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr17:45128812C>T	ENST00000575173.1	-	0	418																											AGTCCTGTTTCTGTGTGGATT	0.373000													4	71					0	0	1	0	0
CUL4B	8450	broad.mit.edu	37	X	119673128	119673128	+	Missense_Mutation	SNP	A	A	G			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chrX:119673128A>G	ENST00000371322.5	-	12	1797	c.1736T>C	c.(1735-1737)aTc>aCc	p.I579T	CUL4B_ENST00000336592.6_Missense_Mutation_p.I584T|CUL4B_ENST00000404115.3_Missense_Mutation_p.I597T	NM_001079872.1	NP_001073341.1	Q13620	CUL4B_HUMAN	cullin 4B	597					cell cycle|DNA repair|ubiquitin-dependent protein catabolic process	Cul4B-RING ubiquitin ligase complex|nucleus	protein binding|ubiquitin protein ligase binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CTTACCATAGATAAATCTAAA	0.289000													17	24					0	0	1	0	0
SYT4	6860	broad.mit.edu	37	18	40850545	40850545	+	Missense_Mutation	SNP	T	T	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr18:40850545T>C	ENST00000255224.3	-	4	1407	c.1039A>G	c.(1039-1041)Aaa>Gaa	p.K347E	SYT4_ENST00000586678.1_Intron|SYT4_ENST00000590752.1_Missense_Mutation_p.K329E	NM_020783.3	NP_065834.1	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	347	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44						GGGGTGCATTTCTTCACATGA	0.408000													56	60					0	0	1	0	0
NF1	4763	broad.mit.edu	37	17	29654516	29654516	+	Splice_Site	SNP	G	G	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr17:29654516G>C	ENST00000358273.4	+	38	5651		c.e38-1		NF1_ENST00000356175.3_Splice_Site|NF1_ENST00000581113.2_Splice_Site	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CCACTTTCCAGGTTGGTTCTA	0.398000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			44	2					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6233023	6233023	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr11:6233023C>T	ENST00000265978.4	-	12	3032	c.2674G>A	c.(2674-2676)Gca>Aca	p.A892T	FAM160A2_ENST00000449352.2_Missense_Mutation_p.A878T|FAM160A2_ENST00000529360.1_5'UTR	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	878					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding	p.A892T(1)		NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ACCAATTGTGCCGCCTGCCGG	0.627000													4	151					0	0	1	0	0
OSBPL2	9885	broad.mit.edu	37	20	60854344	60854344	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr20:60854344G>A	ENST00000313733.3	+	7	825	c.623G>A	c.(622-624)gGc>gAc	p.G208D	OSBPL2_ENST00000358053.2_Missense_Mutation_p.G196D|OSBPL2_ENST00000439951.2_Missense_Mutation_p.G116D	NM_144498.1	NP_653081.1	Q9H1P3	OSBL2_HUMAN	oxysterol binding protein-like 2	208					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;1.33e-06)			AAGTTCTGGGGCAAAAGCGTG	0.587000													3	45					0	0	1	0	0
NCOR1	9611	broad.mit.edu	37	17	15971338	15971338	+	Silent	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr17:15971338C>T	ENST00000268712.3	-	32	4868	c.4611G>A	c.(4609-4611)ggG>ggA	p.G1537G	NCOR1_ENST00000395857.3_Silent_p.G121G|NCOR1_ENST00000395851.1_Silent_p.G1553G	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	1537	Interaction with C1D (By similarity).|Interaction with ETO.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CAGGGTCCACCCCAGGCACTG	0.542000													22	36					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	73					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1582120	1582120	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr17:1582120C>T	ENST00000572621.1	-	11	1920	c.1655G>A	c.(1654-1656)cGt>cAt	p.R552H	PRPF8_ENST00000304992.6_Missense_Mutation_p.R552H			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	552						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		CTTAGTCAAACGCAGAACTTC	0.493000													23	30					0	0	1	0	0
LRCH1	23143	broad.mit.edu	37	13	47266679	47266679	+	Silent	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr13:47266679C>T	ENST00000311191.6	+	8	1252	c.1023C>T	c.(1021-1023)gaC>gaT	p.D341D	LRCH1_ENST00000389797.3_Silent_p.D341D|LRCH1_ENST00000389798.3_Silent_p.D341D	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	341										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		AGCCTTCTGACGAAGACACTG	0.413000													64	81					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578508	9578508	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr19:9578508C>T	ENST00000301480.4	-	10	1328	c.1115G>A	c.(1114-1116)gGg>gAg	p.G372E		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AGGTTTTATCCCAATGTGGGT	0.403000													48	54					0	0	1	0	0
NEBL	10529	broad.mit.edu	37	10	21098829	21098829	+	Splice_Site	SNP	T	T	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr10:21098829T>C	ENST00000377122.4	-	25	2915		c.e25-2		NEBL_ENST00000417816.2_Intron|NEBL_ENST00000377159.4_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette						regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTTTGAGGTCTTTTGCCAAAA	0.393000													18	32					0	0	1	0	0
BLVRB	645	broad.mit.edu	37	19	40953796	40953796	+	Silent	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr19:40953796C>T	ENST00000263368.4	-	5	772	c.621G>A	c.(619-621)taG>taA	p.*207*	BLVRB_ENST00000595483.1_Silent_p.*164*	NM_000713.2	NP_000704.1	P30043	BLVRB_HUMAN	biliverdin reductase B (flavin reductase (NADPH))	0					heme catabolic process	cytosol	biliverdin reductase activity|binding|flavin reductase activity			large_intestine(3)|lung(3)	6			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)		NADH(DB00157)|Riboflavin(DB00140)	GGACAGAGTGCTACTGGTACT	0.537000													15	52					0	0	1	0	0
ACSL4	2182	broad.mit.edu	37	X	108902736	108902736	+	Missense_Mutation	SNP	G	G	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chrX:108902736G>T	ENST00000340800.2	-	16	2329	c.1825C>A	c.(1825-1827)Cag>Aag	p.Q609K	ACSL4_ENST00000469796.2_Missense_Mutation_p.Q609K|ACSL4_ENST00000348502.6_Missense_Mutation_p.Q568K	NM_022977.2	NP_075266.1	O60488	ACSL4_HUMAN	acyl-CoA synthetase long-chain family member 4	609					fatty acid metabolic process|learning or memory|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)	22					Icosapent(DB00159)|Troglitazone(DB00197)	ACATAGGACTGATCACTAAAA	0.323000													39	67					3.21399e-22	3.27464e-22	1	1	0
FKBP4	2288	broad.mit.edu	37	12	2909744	2909744	+	Splice_Site	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr12:2909744G>A	ENST00000001008.4	+	8	1219		c.e8+1		RP4-816N1.6_ENST00000547834.1_RNA|RP4-816N1.7_ENST00000547042.1_RNA	NM_002014.3	NP_002005.1	Q02790	FKBP4_HUMAN	FK506 binding protein 4, 59kDa						negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(1)	14			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	CTGTAACAAGGTGAGGCCCCC	0.547000													29	31					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73280660	73280660	+	Missense_Mutation	SNP	T	T	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr4:73280660T>A	ENST00000286657.4	-	4	569	c.533A>T	c.(532-534)gAg>gTg	p.E178V		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	178					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AATGAAATACTCTTCATTATC	0.353000													52	74					0	0	1	0	0
PMPCB	9512	broad.mit.edu	37	7	102952301	102952301	+	Silent	SNP	T	T	C			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr7:102952301T>C	ENST00000249269.4	+	11	1325	c.1287T>C	c.(1285-1287)taT>taC	p.Y429Y	PMPCB_ENST00000420236.2_Silent_p.Y324Y|PMPCB_ENST00000428154.1_Silent_p.Y429Y	NM_004279.2	NP_004270.2	O75439	MPPB_HUMAN	peptidase (mitochondrial processing) beta	429					proteolysis	mitochondrial matrix	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(9)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						TGTTATGCTATAATAGAAGGA	0.343000													5	47					0	0	1	0	0
TTLL5	23093	broad.mit.edu	37	14	76259309	76259309	+	Missense_Mutation	SNP	G	G	A			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr14:76259309G>A	ENST00000298832.9	+	27	3242	c.3037G>A	c.(3037-3039)Gag>Aag	p.E1013K	TTLL5_ENST00000557636.1_Missense_Mutation_p.E1028K|TTLL5_ENST00000554510.1_Missense_Mutation_p.E522K|TTLL5_ENST00000556893.1_Missense_Mutation_p.E564K	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1013					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		AACACAAAAAGAGGGAGAAGA	0.413000													22	28					0	0	1	0	0
SAP30BP	29115	broad.mit.edu	37	17	73695883	73695883	+	Missense_Mutation	SNP	C	C	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr17:73695883C>T	ENST00000584667.1	+	5	585	c.328C>T	c.(328-330)Cgg>Tgg	p.R110W	SAP30BP_ENST00000579864.1_3'UTR|SAP30BP_ENST00000355423.3_Missense_Mutation_p.R94W	NM_013260.6	NP_037392.1	Q9UHR5	S30BP_HUMAN	SAP30 binding protein	110					apoptosis|induction of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)	17	all_cancers(13;6.42e-08)		all cancers(21;4.25e-07)|Epithelial(20;9.57e-07)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGAAAGAGTTCGGAACATGTC	0.453000													59	86					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331664	85331665	+	Frame_Shift_Ins	INS	-	-	A	rs76299065		TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr1:85331664_85331665insA	ENST00000440886.1	-	1	177_178	c.139_140insT	c.(139-141)taafs	p.*47fs	LPAR3_ENST00000370611.3_Frame_Shift_Ins_p.*47fs|LPAR3_ENST00000491034.1_5'UTR			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	47					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						CAGAGAATTAGAAAAAAAAATA	0.401													7	149	---	---	---	---					
CTBP1	1487	broad.mit.edu	37	4	1232006	1232008	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr4:1232006_1232008delAGA	ENST00000510568.1	-	2	716_718	c.125_127delTCT	c.(124-129)tgc>t	p.FC42del	CTBP1_ENST00000290921.6_In_Frame_Del_p.FC53del|CTBP1_ENST00000515690.1_5'UTR|CTBP1_ENST00000382952.3_In_Frame_Del_p.FC42del			Q13363	CTBP1_HUMAN	C-terminal binding protein 1	53	Interaction with GLIS2 1 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		TGCGCGTCGCAGAAGGCCACAGT	0.665													38	61	---	---	---	---					
TBC1D9	23158	broad.mit.edu	37	4	141677078	141677080	+	In_Frame_Del	DEL	CCG	CCG	-			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr4:141677078_141677080delCCG	ENST00000442267.2	-	1	194_196	c.120_122delCGG	c.(118-123)gga>gg	p.GG40del		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	40						intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				ACCCGCCAGTCCGCCGCCGCCGC	0.739													3	6	---	---	---	---					
ZNF292	23036	broad.mit.edu	37	6	87865403	87865404	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr6:87865403_87865404insT	ENST00000369577.3	+	1	137_138	c.94_95insT	c.(94-96)ggafs	p.G32fs	ZNF292_ENST00000392985.3_Frame_Shift_Ins_p.G32fs|ZNF292_ENST00000369578.2_3'UTR|ZNF292_ENST00000339907.4_Frame_Shift_Ins_p.G32fs	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	32					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		GCTCCAGGAGCTGGAGCTACAG	0.703													6	5	---	---	---	---					
RP11-274B21.1	0	broad.mit.edu	37	7	128255832	128255833	+	RNA	INS	-	-	T			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr7:128255832_128255833insT	ENST00000605862.1	+	0	758																											TATAGAAATGATTTTTTTTTTC	0.282													2	4	---	---	---	---					
C9orf43	257169	broad.mit.edu	37	9	116187646	116187648	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr9:116187646_116187648delGCA	ENST00000288462.4	+	10	1334_1336	c.888_890delGCA	c.(886-891)cgg>cg	p.RQ296del	C9orf43_ENST00000374165.1_In_Frame_Del_p.RQ296del	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	296	Gln-rich.									breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						agcagcagcggcagcagcagcag	0.557													8	123	---	---	---	---					
VAV2	7410	broad.mit.edu	37	9	136648690	136648691	+	Frame_Shift_Ins	INS	-	-	TG			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr9:136648690_136648691insTG	ENST00000371851.1	-	17	1952_1953	c.1627_1628insCA	c.(1627-1629)gtgfs	p.V543fs	VAV2_ENST00000406606.3_Frame_Shift_Ins_p.V543fs|VAV2_ENST00000371850.3_Frame_Shift_Ins_p.V553fs			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	553					angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		CTTGGTACACATGTATCCCTGG	0.629													11	43	---	---	---	---					
BEND7	222389	broad.mit.edu	37	10	13534788	13534788	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr10:13534788delT	ENST00000341083.3	-	5	800	c.504delA	c.(502-504)aafs	p.K168fs	BEND7_ENST00000396898.2_Frame_Shift_Del_p.K233fs|BEND7_ENST00000396900.2_Frame_Shift_Del_p.K220fs|BEND7_ENST00000378605.3_Frame_Shift_Del_p.K181fs	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	220							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						TTGGGGGCACTTTTTTCTTTT	0.458													51	75	---	---	---	---					
SCFD1	23256	broad.mit.edu	37	14	31091567	31091569	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr14:31091567_31091569delCAG	ENST00000458591.2	+	1	250_252	c.23_25delCAG	c.(22-27)aca>a	p.TA8del	SCFD1_ENST00000396629.2_5'UTR|SCFD1_ENST00000421551.3_5'UTR|SCFD1_ENST00000541123.1_5'UTR|SCFD1_ENST00000544052.2_5'UTR	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	8	Poly-Ala.				post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		gcggcagcgacagcagcagcagc	0.645													2	4	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													4	5	---	---	---	---					
ZNF446	55663	broad.mit.edu	37	19	58991096	58991096	+	Splice_Site	DEL	T	T	-			TCGA-FG-A87N-01A-11D-A36O-08	TCGA-FG-A87N-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	031a2d19-942c-4c6d-afbe-b6135c7ea704	d87821a1-0286-4e2e-ab6a-5b94ddecf27e	g.chr19:58991096delT	ENST00000596341.1	+	5	2932		c.e5+2		ZNF446_ENST00000335841.4_Intron|ZNF446_ENST00000594369.1_Splice_Site			Q9NWS9	ZN446_HUMAN	zinc finger protein 446						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		TCTCCCTGGGTGAGGACCAGC	0.677													2	4	---	---	---	---