Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUC2	4583	broad.mit.edu	37	11	1093740	1093740	+	Silent	SNP	G	G	C			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr11:1093740G>C	ENST00000441003.2	+	30	5586	c.5559G>C	c.(5557-5559)ccG>ccC	p.P1853P	MUC2_ENST00000333592.6_Silent_p.P141P|MUC2_ENST00000361558.6_Intron	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	1856						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CCAATCCTCCGCCTGAGTCCT	0.602000													58	121					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50740356	50740356	+	Splice_Site	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr6:50740356A>G	ENST00000008391.3	+	8	1367		c.e8-1			NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)								DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TCTCATTTCCAGTTTGATCAC	0.378000													4	34					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52430944	52430944	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr3:52430944C>T	ENST00000420323.2	+	73	11932	c.11671C>T	c.(11671-11673)Cgg>Tgg	p.R3891W		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3956	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGACTGGGACCGGCGCTGCAT	0.607000													17	17					0	0	1	0	0
FKBP15	23307	broad.mit.edu	37	9	115945062	115945062	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr9:115945062T>C	ENST00000238256.3	-	19	2015	c.1898A>G	c.(1897-1899)cAt>cGt	p.H633R		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	633					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						TTGTTCAGCATGCAATACTCT	0.463000													81	119					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26967554	26967554	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr13:26967554A>G	ENST00000381527.3	+	7	1200	c.697A>G	c.(697-699)Ata>Gta	p.I233V	CDK8_ENST00000536792.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	233	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		GTCAGAACCAATATTTCACTG	0.343000													7	138					0	0	1	0	0
MTMR14	64419	broad.mit.edu	37	3	9695406	9695406	+	Silent	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr3:9695406G>A	ENST00000296003.4	+	2	383	c.261G>A	c.(259-261)cgG>cgA	p.R87R	MTMR14_ENST00000351233.5_Silent_p.R87R|MTMR14_ENST00000353332.5_Silent_p.R87R|MTMR14_ENST00000420925.1_Intron	NM_001077525.2	NP_001070993.1	Q8NCE2	MTMRE_HUMAN	myotubularin related protein 14	87						perinuclear region of cytoplasm|ruffle	phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(2)|lung(10)|skin(3)|upper_aerodigestive_tract(2)	21	Medulloblastoma(99;0.227)					ACTATCCCCGGCACATCGTGT	0.507000													4	98					0	0	1	0	0
CDYL	9425	broad.mit.edu	37	6	4937890	4937890	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr6:4937890G>A	ENST00000328908.5	+	6	1333	c.1202G>A	c.(1201-1203)tGt>tAt	p.C401Y	CDYL_ENST00000397588.3_Missense_Mutation_p.C347Y|CDYL_ENST00000343762.5_Missense_Mutation_p.C215Y|CDYL_ENST00000449732.2_Missense_Mutation_p.C215Y|CDYL_ENST00000472453.1_3'UTR			Q9Y232	CDYL1_HUMAN	chromodomain protein, Y-like	401					regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	histone acetyltransferase activity			breast(2)|kidney(2)|large_intestine(9)|lung(13)|skin(1)|stomach(2)|urinary_tract(1)	30	Ovarian(93;0.11)	all_hematologic(90;0.0901)|Lung NSC(90;0.244)		OV - Ovarian serous cystadenocarcinoma(45;0.182)		GTCTTCTGTTGTGGACTTGAC	0.458000													10	58					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	58					0	0	1	0	0
TDRD6	221400	broad.mit.edu	37	6	46660172	46660172	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr6:46660172A>G	ENST00000544460.1	+	1	4561	c.4307A>G	c.(4306-4308)cAt>cGt	p.H1436R	TDRD6_ENST00000316081.6_Missense_Mutation_p.H1436R	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1436					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AAAATGATGCATTACTTTTCC	0.398000													10	171					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113400550	113400550	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr12:113400550G>A	ENST00000228928.7	+	9	2106	c.1927G>A	c.(1927-1929)Ggc>Agc	p.G643S	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	643	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						CTGGGAGCAGGGCTGCAGGCA	0.597000													15	98					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	31					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38143490	38143490	+	Missense_Mutation	SNP	C	C	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr13:38143490C>A	ENST00000379747.4	-	21	2495	c.2378G>T	c.(2377-2379)gGt>gTt	p.G793V	POSTN_ENST00000379749.4_Intron|POSTN_ENST00000379743.4_Missense_Mutation_p.G766V|POSTN_ENST00000541179.1_Intron|POSTN_ENST00000541481.1_Missense_Mutation_p.G706V|POSTN_ENST00000497145.1_5'UTR|POSTN_ENST00000379742.4_Missense_Mutation_p.G736V	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	793					cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding	p.G793D(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ACCATCACCACCTTCAATGAA	0.363000													22	47					0.000295444	0.000295444	1	1	0
CD68	968	broad.mit.edu	37	17	7484227	7484227	+	Silent	SNP	G	G	A	rs149306377		TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr17:7484227G>A	ENST00000250092.6	+	5	985	c.774G>A	c.(772-774)tcG>tcA	p.S258S	CD68_ENST00000380498.6_Silent_p.S231S	NM_001251.2	NP_001242.2	P34810	CD68_HUMAN	CD68 molecule	258						endosome membrane|integral to membrane|lysosomal membrane|membrane fraction|plasma membrane				endometrium(1)|lung(1)|skin(1)	3						GGACATTCTCGGCTCAGAATG	0.562000													9	43					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169512035	169512035	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr1:169512035C>T	ENST00000367796.3	-	13	2509	c.2308G>A	c.(2308-2310)Gtt>Att	p.V770I	F5_ENST00000367797.3_Missense_Mutation_p.V765I			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	765	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTTGAAGAAACGAATTCAGTG	0.393000													60	94					0	0	1	0	0
HERC2P3	0	broad.mit.edu	37	15	20644560	20644560	+	RNA	SNP	G	G	C	rs11248783		TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr15:20644560G>C	ENST00000428453.1	-	0	3187																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						ACAGGGAAGGGAGACGGCCAC	0.632000													4	6					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	34					0	0	1	0	0
GSG2	83903	broad.mit.edu	37	17	3628342	3628342	+	Missense_Mutation	SNP	C	C	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr17:3628342C>A	ENST00000325418.4	+	1	1132	c.1113C>A	c.(1111-1113)gaC>gaA	p.D371E	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_Intron	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	371					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										CCACCCAGGACCTGACTCCTT	0.488000													18	30					2.4624e-09	2.565e-09	1	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84607526	84607526	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr9:84607526G>A	ENST00000344803.2	+	4	2188	c.2141G>A	c.(2140-2142)cGt>cAt	p.R714H		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TCATTGCTACGTCCTCAGAGC	0.473000													23	25					0	0	1	0	0
ASTL	431705	broad.mit.edu	37	2	96799705	96799705	+	Splice_Site	SNP	G	G	A	rs148110898		TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr2:96799705G>A	ENST00000342380.2	-	4	335	c.337_splice	c.e4+1	p.Y112_splice		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	112					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						CTCACTCACCGTACTTGCTGG	0.582000													12	13					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178421757	178421757	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr1:178421757A>G	ENST00000448150.3	+	11	2743	c.1925A>G	c.(1924-1926)aAg>aGg	p.K642R	RASAL2_ENST00000367649.3_Missense_Mutation_p.K660R|RASAL2_ENST00000462775.1_Missense_Mutation_p.K512R	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	512					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CTTATTGCCAAGGTCATTCAG	0.418000													25	57					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								18	21					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122757971	122757971	+	Silent	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:122757971A>G	ENST00000245838.8	-	27	3289	c.3258T>C	c.(3256-3258)gaT>gaC	p.D1086D	THOC2_ENST00000491737.1_Silent_p.D971D|THOC2_ENST00000355725.4_Silent_p.D1086D	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1086					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						AGTCTAATTGATCAGCCTTAT	0.323000													33	31					0	0	1	0	0
MEFV	4210	broad.mit.edu	37	16	3293588	3293588	+	Silent	SNP	C	C	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr16:3293588C>T	ENST00000219596.1	-	10	1938	c.1899G>A	c.(1897-1899)ccG>ccA	p.P633P	MEFV_ENST00000536379.1_Silent_p.P422P|MEFV_ENST00000541159.1_3'UTR|MEFV_ENST00000339854.4_Silent_p.P453P	NM_000243.2	NP_000234.1	O15553	MEFV_HUMAN	Mediterranean fever	633	B30.2/SPRY.				inflammatory response	cytoplasm|microtubule|microtubule associated complex|nucleus	actin binding|zinc ion binding			NS(2)|biliary_tract(1)|breast(5)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(3)|prostate(1)|skin(6)	50					Colchicine(DB01394)	CAAATCTTTGCGGGCCATCAG	0.517000													4	240					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49071867	49071867	+	Missense_Mutation	SNP	C	C	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:49071867C>T	ENST00000376265.2	-	28	3467	c.3406G>A	c.(3406-3408)Gtc>Atc	p.V1136I	CACNA1F_ENST00000323022.5_Missense_Mutation_p.V1125I|CACNA1F_ENST00000376251.1_Missense_Mutation_p.V1071I	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1136	Dihydropyridine binding (By similarity).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GTGATGATGACGAAGCCCACG	0.502000													7	16					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42791836	42791836	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr19:42791836T>C	ENST00000572681.2	+	6	3517	c.3449T>C	c.(3448-3450)cTg>cCg	p.L1150P	CIC_ENST00000160740.3_Missense_Mutation_p.L241P|CIC_ENST00000575354.2_Missense_Mutation_p.L241P			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	241	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				TGGTATGCCCTGGGGCCCAAG	0.612000			"""Mis, F, S"""		oligodendroglioma								15	7					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109370354	109370354	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr2:109370354A>G	ENST00000283195.6	+	15	2255	c.2129A>G	c.(2128-2130)tAt>tGt	p.Y710C		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	710					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TGCAAAAATTATCTGAGAAAG	0.348000													76	93					0	0	1	0	0
DRD3	1814	broad.mit.edu	37	3	113847660	113847660	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr3:113847660G>A	ENST00000383673.2	-	7	1536	c.1106C>T	c.(1105-1107)aCa>aTa	p.T369I	DRD3_ENST00000467632.1_Missense_Mutation_p.T369I|DRD3_ENST00000460779.1_Missense_Mutation_p.T369I|DRD3_ENST00000295881.7_Missense_Mutation_p.T336I	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	369					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GCCCAGCCATGTCGTGGCACT	0.542000													93	143					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431378	135431378	+	Missense_Mutation	SNP	A	A	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:135431378A>T	ENST00000394143.1	+	6	5804	c.5513A>T	c.(5512-5514)tAt>tTt	p.Y1838F	GPR112_ENST00000287534.4_Missense_Mutation_p.Y1775F|GPR112_ENST00000370652.1_Missense_Mutation_p.Y1838F|GPR112_ENST00000394141.1_Missense_Mutation_p.Y1633F|GPR112_ENST00000412101.1_Missense_Mutation_p.Y1633F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1838					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TCATTTGTTTATTCACCTCAT	0.438000													14	103					0	0	1	0	0
PAGE1	8712	broad.mit.edu	37	X	49459349	49459349	+	Missense_Mutation	SNP	A	A	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:49459349A>T	ENST00000376150.3	-	2	157	c.25T>A	c.(25-27)Tat>Aat	p.Y9N		NM_003785.3	NP_003776.2	O75459	GAGB1_HUMAN	P antigen family, member 1 (prostate associated)	9					cellular defense response					endometrium(1)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	7	Ovarian(276;0.236)					CTACGCCGATAGATTAATCTT	0.373000													16	15					0	0	1	0	0
AFF1	4299	broad.mit.edu	37	4	88047292	88047292	+	Missense_Mutation	SNP	T	T	C			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr4:88047292T>C	ENST00000307808.6	+	13	3014	c.2594T>C	c.(2593-2595)cTc>cCc	p.L865P	AFF1_ENST00000395146.4_Missense_Mutation_p.L872P|AFF1_ENST00000544085.1_Missense_Mutation_p.L503P	NM_005935.2	NP_005926.1	P51825	AFF1_HUMAN	AF4/FMR2 family, member 1	865						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(2)	3		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		AAGGAAATGCTCCCCCCGCCA	0.577000													8	75					0	0	1	0	0
MAP3K12	7786	broad.mit.edu	37	12	53880246	53880246	+	Missense_Mutation	SNP	C	C	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr12:53880246C>G	ENST00000267079.2	-	4	732	c.507G>C	c.(505-507)aaG>aaC	p.K169N	MAP3K12_ENST00000547488.1_Missense_Mutation_p.K202N|MAP3K12_ENST00000547035.1_Missense_Mutation_p.K202N|MAP3K12_ENST00000547151.1_5'UTR	NM_001193511.1|NM_006301.3	NP_001180440.1|NP_006292.3	Q12852	M3K12_HUMAN	mitogen-activated protein kinase kinase kinase 12	169	Protein kinase.				histone phosphorylation|JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation	cytosol|membrane fraction|plasma membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(2)|breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	37						TGTTGGGGTGCTTCAGCTTTC	0.582000													12	41					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662867	99662867	+	Silent	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:99662867G>A	ENST00000373034.4	-	1	2404	c.729C>T	c.(727-729)taC>taT	p.Y243Y	PCDH19_ENST00000420881.2_Silent_p.Y243Y|PCDH19_ENST00000255531.7_Silent_p.Y243Y	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	243	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						CGCTCACCGCGTAGGTGGACT	0.627000													19	94					0	0	1	0	0
CHD6	0	broad.mit.edu	37	20	40102094	40102094	+	Silent	SNP	C	C	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr20:40102094C>G	ENST00000373233.3	-	17	2709	c.2532G>C	c.(2530-2532)cgG>cgC	p.R844R	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	844	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GCTTACAGAACCGGTCGATGG	0.537000													4	46					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9014244	9014244	+	Missense_Mutation	SNP	C	C	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr16:9014244C>G	ENST00000344836.4	-	5	781	c.583G>C	c.(583-585)Gta>Cta	p.V195L	USP7_ENST00000535863.1_Missense_Mutation_p.V96L|USP7_ENST00000381886.4_Missense_Mutation_p.V179L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	195	Interaction with TSPYL5.|Interaction with p53/TP53, MDM2 and EBNA1.|MATH.|Necessary for nuclear localization.				interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						TCCGCCTGTACAAAGACTTCA	0.378000													25	38					0	0	1	0	0
GPR119	139760	broad.mit.edu	37	X	129519123	129519123	+	Missense_Mutation	SNP	G	G	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:129519123G>T	ENST00000276218.2	-	1	388	c.299C>A	c.(298-300)aCc>aAc	p.T100N		NM_178471.2	NP_848566.1	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	100						integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(3)|prostate(1)	11						CCTGTCAAAGGTGATCAGCAT	0.587000													101	122					1.79411e-48	1.90862e-48	1	1	0
SEMA3A	10371	broad.mit.edu	37	7	83739852	83739852	+	Silent	SNP	C	C	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr7:83739852C>T	ENST00000265362.3	-	4	701	c.387G>A	c.(385-387)ttG>ttA	p.L129L	SEMA3A_ENST00000436949.1_Silent_p.L129L	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	129	Sema.				axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						CACAGGCGTACAAGTGAGTCT	0.383000													13	87					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17429999	17429999	+	Missense_Mutation	SNP	T	T	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr11:17429999T>A	ENST00000302539.4	-	23	2888	c.2763A>T	c.(2761-2763)gaA>gaT	p.E921D	ABCC8_ENST00000389817.3_Missense_Mutation_p.E920D	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	920	ABC transporter 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	AGAGCTGGCATTCAGACCTCT	0.557000													15	43					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117786329	117786329	+	Missense_Mutation	SNP	A	A	G			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr9:117786329A>G	ENST00000350763.4	-	27	6829	c.6418T>C	c.(6418-6420)Tac>Cac	p.Y2140H	TNC_ENST00000537320.1_Missense_Mutation_p.Y1503H|TNC_ENST00000346706.3_Missense_Mutation_p.Y1594H|TNC_ENST00000423613.2_Missense_Mutation_p.Y1867H|TNC_ENST00000341037.4_Missense_Mutation_p.Y1958H|TNC_ENST00000345230.3_Missense_Mutation_p.Y1503H|TNC_ENST00000535648.1_Missense_Mutation_p.Y1685H|TNC_ENST00000542877.1_Missense_Mutation_p.Y1777H|TNC_ENST00000340094.3_Missense_Mutation_p.Y1776H	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2140	Fibrinogen C-terminal.			YKGA -> TRG (in Ref. 2; CAA39628).	cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						GCCCCTTTGTAGGACAGAGCA	0.537000													3	75					0	0	1	0	0
INSR	0	broad.mit.edu	37	19	7132266	7132266	+	Silent	SNP	C	C	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr19:7132266C>A	ENST00000341500.5	-	13	2748	c.2709G>T	c.(2707-2709)ggG>ggT	p.G903G	INSR_ENST00000302850.5_Silent_p.G915G	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	915	Fibronectin type-III 3.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCGGTGACAGCCCACGCAGCC	0.617000													13	18					4.3838e-07	4.47327e-07	1	1	0
ACKR4	51554	broad.mit.edu	37	3	132319326	132319326	+	Silent	SNP	C	C	T			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr3:132319326C>T	ENST00000249887.2	+	2	181	c.85C>T	c.(85-87)Ctg>Ttg	p.L29L	ACAD11_ENST00000264990.6_Intron|ACAD11_ENST00000355458.3_Intron|ACAD11_ENST00000545291.1_Intron	NM_016557.2|NM_178445.2	NP_057641.1|NP_848540.1			atypical chemokine receptor 4									p.L29L(1)									TCAATATGAACTGATCTGTAT	0.378000													4	23					0	0	1	0	0
C9orf3	84909	broad.mit.edu	37	9	97843039	97843039	+	Missense_Mutation	SNP	G	G	A			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr9:97843039G>A	ENST00000375315.2	+	14	2296	c.2296G>A	c.(2296-2298)Gag>Aag	p.E766K	C9orf3_ENST00000433691.2_Missense_Mutation_p.E107K|C9orf3_ENST00000425634.2_Missense_Mutation_p.E128K|C9orf3_ENST00000297979.5_Missense_Mutation_p.E667K	NM_001193329.1	NP_001180258.1	Q8N6M6	AMPO_HUMAN	chromosome 9 open reading frame 3	766					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		CAAAAGTGTGGAGAGGTTCCT	0.502000													12	41					0	0	1	0	0
MAGI3	260425	broad.mit.edu	37	1	113933961	113933962	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr1:113933961_113933962delTG	ENST00000369615.1	+	1	368_369	c.306_307delTG	c.(304-309)actgfs	p.TV102fs	MAGI3_ENST00000369611.4_Frame_Shift_Del_p.TV102fs|MAGI3_ENST00000307546.9_Frame_Shift_Del_p.TV102fs|MAGI3_ENST00000369617.4_Frame_Shift_Del_p.TV102fs|MAGI3_ENST00000486456.1_3'UTR	NM_152900.2	NP_690864.2	Q5TCQ9	MAGI3_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 3	102	Interaction with ADRB1 and TGFA (By similarity).|PDZ 1.				apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	41	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTCTCAAGACTGTGAAACCAGG	0.663													2	4	---	---	---	---					
ZNF876P	0	broad.mit.edu	37	4	206717	206736	+	RNA	DEL	GGGACCCGCGCTCCTGTCGG	GGGACCCGCGCTCCTGTCGG	-	rs36228091		TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr4:206717_206736delGGGACCCGCGCTCCTGTCGG	ENST00000356347.3	+	0	172					NR_027481.1																						CCTCCGGTGAGGGACCCGCGCTCCTGTCGGGGGACCCGCG	0.718													4	4	---	---	---	---					
DND1	373863	broad.mit.edu	37	5	140052285	140052285	+	Frame_Shift_Del	DEL	T	T	-			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr5:140052285delT	ENST00000542735.1	-	3	392	c.349delA	c.(349-351)cgfs	p.T117fs		NM_194249.2	NP_919225.1	Q8IYX4	DND1_HUMAN	DND microRNA-mediated repression inhibitor 1	117	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding	p.T117fs*24(1)		central_nervous_system(1)|prostate(4)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGCAGCGTGGCGATGGCG	0.682													2	4	---	---	---	---					
OR4E2	26686	broad.mit.edu	37	14	22134124	22134124	+	Frame_Shift_Del	DEL	A	A	-			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chr14:22134124delA	ENST00000408935.1	+	1	828	c.828delA	c.(826-828)acfs	p.T276fs		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TCTTCTACACAGTGGTCACCC	0.473													17	23	---	---	---	---					
ELF4	2000	broad.mit.edu	37	X	129201056	129201056	+	Frame_Shift_Del	DEL	G	G	-			TCGA-R8-A73M-01A-11D-A32B-08	TCGA-R8-A73M-10C-01D-A329-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a8644f8a-beac-4a95-8b6a-e4e081917313	a243fe0c-19bb-49b3-8547-48cb29ace8e3	g.chrX:129201056delG	ENST00000308167.5	-	9	2011	c.1632delC	c.(1630-1632)tcfs	p.S545fs	ELF4_ENST00000335997.7_Frame_Shift_Del_p.S545fs	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	545					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						GAACATAGGAGGAGGACCTCA	0.617			T	ERG	AML								7	91	---	---	---	---