Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM83G	644815	broad.mit.edu	37	17	18881175	18881175	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr17:18881175G>A	ENST00000388995.6	-	5	2027	c.1804C>T	c.(1804-1806)Cgt>Tgt	p.R602C	FAM83G_ENST00000345041.4_Missense_Mutation_p.R602C|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395647.2_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.R602C|SLC5A10_ENST00000395645.3_Intron|SLC5A10_ENST00000317977.6_Intron			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	602										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						CCAGGGCCACGGCCGGAGCTG	0.637000													20	150					0	0	1	0	0
SDHA	6389	broad.mit.edu	37	5	236619	236619	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr5:236619T>C	ENST00000264932.6	+	10	1452	c.1337T>C	c.(1336-1338)gTa>gCa	p.V446A	SDHA_ENST00000504309.1_Missense_Mutation_p.V446A|SDHA_ENST00000510361.1_Missense_Mutation_p.V398A	NM_004168.2	NP_004159.2	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	446					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|liver(2)|lung(16)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	40			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	TGTGCCTCGGTACATGGTGCC	0.602000									Familial Paragangliomas				5	146					0	0	1	0	0
HDAC4	9759	broad.mit.edu	37	2	240005917	240005917	+	Silent	SNP	G	G	A	rs149230665		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr2:240005917G>A	ENST00000345617.3	-	20	3242	c.2451C>T	c.(2449-2451)tcC>tcT	p.S817S	HDAC4_ENST00000543185.1_Silent_p.S401S	NM_006037.3	NP_006028.2	P56524	HDAC4_HUMAN	histone deacetylase 4	817	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(5)	62		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		CCACGGCCACGGAGTTGAAGT	0.632000													3	35					0	0	1	0	0
SRPR	6734	broad.mit.edu	37	11	126135974	126135974	+	Missense_Mutation	SNP	G	G	A	rs138456100	byFrequency	TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr11:126135974G>A	ENST00000332118.6	-	8	1089	c.935C>T	c.(934-936)gCg>gTg	p.A312V	SRPR_ENST00000532259.1_Missense_Mutation_p.A284V	NM_003139.3	NP_003130.2	P08240	SRPR_HUMAN	signal recognition particle receptor (docking protein)	312					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding			endometrium(7)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)	21	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TCCCTTGGTCGCACTGCAGGG	0.478000													5	383					0	0	1	0	0
PTK2	5747	broad.mit.edu	37	8	141762391	141762391	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr8:141762391T>C	ENST00000522684.1	-	17	1586	c.1357A>G	c.(1357-1359)Att>Gtt	p.I453V	PTK2_ENST00000340930.3_Missense_Mutation_p.I453V|PTK2_ENST00000519465.1_Missense_Mutation_p.I81V|PTK2_ENST00000520151.1_Missense_Mutation_p.I81V|PTK2_ENST00000535192.1_Missense_Mutation_p.I453V|PTK2_ENST00000517887.1_Missense_Mutation_p.I497V|PTK2_ENST00000519419.1_Missense_Mutation_p.I497V|PTK2_ENST00000395218.2_Missense_Mutation_p.I453V|PTK2_ENST00000538769.1_Missense_Mutation_p.I121V|PTK2_ENST00000521059.1_Missense_Mutation_p.I453V	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	453	Protein kinase.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			CATGTTTTAATTGCAACCGCC	0.368000													4	161					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49440276	49440276	+	Silent	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr10:49440276G>A	ENST00000374201.3	-	10	1352	c.1050C>T	c.(1048-1050)aaC>aaT	p.N350N	FRMPD2_ENST00000305531.3_Silent_p.N326N|FRMPD2_ENST00000407470.4_Silent_p.N319N	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	350	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GGTGCTGCCCGTTCAGCAGGA	0.443000													4	134					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39263907	39263907	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr13:39263907G>A	ENST00000280481.7	+	1	2642	c.2426G>A	c.(2425-2427)cGa>cAa	p.R809Q		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	809					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTGGAAGACCGAGCTGGGAAT	0.542000													14	123					0	0	1	0	0
NEK8	284086	broad.mit.edu	37	17	27061088	27061088	+	Silent	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr17:27061088G>A	ENST00000268766.6	+	2	169	c.135G>A	c.(133-135)cgG>cgA	p.R45R	NEK8_ENST00000593261.1_3'UTR|AC010761.6_ENST00000584779.1_RNA	NM_178170.2	NP_835464.1	Q86SG6	NEK8_HUMAN	NIMA-related kinase 8	45	Protein kinase.					cytoplasm|primary cilium	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Lung NSC(42;0.0158)					AGGAAGAGCGGCAGGCAGCCC	0.527000													10	127					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627785	43627785	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr9:43627785G>T	ENST00000332857.6	-	4	930	c.902C>A	c.(901-903)cCt>cAt	p.P301H	SPATA31A6_ENST00000496386.1_5'UTR	NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		GCGGGAAAGAGGATCTTGCTG	0.547000													6	951					0.000157383	0.000162152	1	1	0
PSME1	5720	broad.mit.edu	37	14	24606754	24606754	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr14:24606754A>C	ENST00000382708.3	+	5	335	c.272A>C	c.(271-273)aAg>aCg	p.K91T	PSME1_ENST00000559123.1_5'UTR|PSME1_ENST00000470718.1_3'UTR|PSME1_ENST00000206451.6_Missense_Mutation_p.K91T|PSME1_ENST00000561435.1_Missense_Mutation_p.K91T	NM_176783.1	NP_788955.1	Q06323	PSME1_HUMAN	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	91					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|proteasome activator complex				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				GBM - Glioblastoma multiforme(265;0.00831)		GAAAAGAAGAAGGGGGAGGAT	0.488000													17	101					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70841641	70841641	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr16:70841641G>A	ENST00000393567.2	-	86	15358	c.15208C>T	c.(15208-15210)Cgg>Tgg	p.R5070W		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	5070										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TTCTTGGGCCGCACAGACTCT	0.517000													4	219					0	0	1	0	0
TRAIP	10293	broad.mit.edu	37	3	49869465	49869465	+	Silent	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr3:49869465C>T	ENST00000331456.2	-	11	1034	c.921G>A	c.(919-921)cgG>cgA	p.R307R	TRAIP_ENST00000469027.1_Silent_p.R152R	NM_005879.2	NP_005870.2	Q9BWF2	TRAIP_HUMAN	TRAF interacting protein	307	Interaction with CYLD.				cell proliferation|induction of apoptosis	perinuclear region of cytoplasm	protein binding|zinc ion binding	p.R307R(2)		breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGAAGGATGGCCGGCGGAGCT	0.547000													17	110					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2236990	2236990	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr16:2236990C>A	ENST00000343516.6	-	9	1011	c.919G>T	c.(919-921)Gac>Tac	p.D307Y		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	307	SH3.				signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						GTGATGATGTCCCCTGCCTTC	0.652000													13	144					0.00185496	0.00188264	1	1	0
PLEKHG5	57449	broad.mit.edu	37	1	6530295	6530295	+	Splice_Site	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr1:6530295C>T	ENST00000377748.1	-	17	2529		c.e17+1		PLEKHG5_ENST00000535355.1_Splice_Site|PLEKHG5_ENST00000537245.1_Splice_Site|PLEKHG5_ENST00000544978.1_Splice_Site|PLEKHG5_ENST00000400913.1_Splice_Site|PLEKHG5_ENST00000377725.1_Splice_Site|PLEKHG5_ENST00000400915.3_Splice_Site|PLEKHG5_ENST00000377732.1_Splice_Site|PLEKHG5_ENST00000377737.2_Splice_Site|PLEKHG5_ENST00000377728.3_Splice_Site|PLEKHG5_ENST00000377740.3_Splice_Site|PLEKHG5_ENST00000340850.5_Splice_Site	NM_198681.3	NP_941374.2	O94827	PKHG5_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 5						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			liver(1)	1	Ovarian(185;0.02)|all_lung(157;0.154)	all_cancers(23;1.7e-35)|all_epithelial(116;2.78e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Colorectal(325;4.47e-05)|all_hematologic(16;0.00014)|Breast(487;0.000688)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0448)		Epithelial(90;5.51e-35)|GBM - Glioblastoma multiforme(13;3.57e-27)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|BRCA - Breast invasive adenocarcinoma(365;0.00107)|STAD - Stomach adenocarcinoma(132;0.00159)|READ - Rectum adenocarcinoma(331;0.0419)		CCTGGAATCACCTTGCTGTCC	0.662000													9	76					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43305558	43305558	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr6:43305558C>T	ENST00000361428.2	-	10	6255	c.6178G>A	c.(6178-6180)Gct>Act	p.A2060T	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	2060					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			TCGAAGTCAGCGGGATCGGAG	0.458000													4	167					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49197893	49197893	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr17:49197893T>C	ENST00000262013.7	-	1	333	c.125A>G	c.(124-126)tAt>tGt	p.Y42C	SPAG9_ENST00000505279.1_Missense_Mutation_p.Y42C|SPAG9_ENST00000357122.4_Missense_Mutation_p.Y42C	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	42					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			CTCCTCGTCATAGCGCCCGAT	0.667000													6	36					0	0	1	0	0
WNT2	7472	broad.mit.edu	37	7	116955280	116955280	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr7:116955280C>T	ENST00000265441.3	-	3	732	c.433G>A	c.(433-435)Gcc>Acc	p.A145T	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	145					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CTGTCCTTGGCGCTTCCCATC	0.473000													6	196					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38829460	38829460	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr4:38829460G>T	ENST00000436693.2	-	2	1754	c.1635C>A	c.(1633-1635)gaC>gaA	p.D545E	TLR6_ENST00000381950.1_Missense_Mutation_p.D545E	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	545	LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGATACTTGGTCTATATTTT	0.418000													6	566					8.12818e-05	8.6362e-05	1	1	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	G	A	rs121913499		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr2:209113113G>A	ENST00000415913.1	-	4	775	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	IDH1_ENST00000345146.2_Missense_Mutation_p.R132C|IDH1_ENST00000446179.1_Missense_Mutation_p.R132C			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132C(446)|p.R132G(125)|p.R132S(106)|p.G131_R132>VL(1)|p.R132V(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma								21	175					0	0	1	0	0
DNMT3L	29947	broad.mit.edu	37	21	45666374	45666374	+	Missense_Mutation	SNP	G	G	A	rs141318231		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr21:45666374G>A	ENST00000270172.3	-	12	1553	c.1070C>T	c.(1069-1071)gCg>gTg	p.A357V	DNMT3L_ENST00000418993.1_Missense_Mutation_p.A356V	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	356					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		CCACTTGGCCGCGAGCTTCGA	0.507000													5	148					0	0	1	0	0
SFRP2	6423	broad.mit.edu	37	4	154709562	154709562	+	Silent	SNP	G	G	A	rs142242428	byFrequency	TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr4:154709562G>A	ENST00000274063.4	-	1	710	c.426C>T	c.(424-426)tgC>tgT	p.C142C		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	142	FZ.				brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				GGAAACGGTCGCACTCAAGCA	0.647000													13	135					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124333279	124333279	+	Splice_Site	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr10:124333279G>A	ENST00000338354.3	+	6	389		c.e6+1		DMBT1_ENST00000359586.6_Splice_Site|DMBT1_ENST00000330163.4_Splice_Site|DMBT1_ENST00000368909.3_Splice_Site|DMBT1_ENST00000368955.3_Splice_Site|DMBT1_ENST00000344338.3_Splice_Site|DMBT1_ENST00000368956.2_Splice_Site			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1						epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTAGCAGAAGGTAACGTCTAC	0.527000													35	330					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	150834225	150834225	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr3:150834225C>T	ENST00000474524.1	+	2	238	c.200C>T	c.(199-201)tCa>tTa	p.S67L	MED12L_ENST00000309237.4_Missense_Mutation_p.S67L|MED12L_ENST00000422248.2_Missense_Mutation_p.S67L|MED12L_ENST00000273432.4_Missense_Mutation_p.S67L	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	67					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATTAACCCATCAAAGGTAATG	0.363000													9	51					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85973974	85973974	+	Missense_Mutation	SNP	G	G	A	rs142917517		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr10:85973974G>A	ENST00000372117.3	+	17	2280	c.2177G>A	c.(2176-2178)cGc>cAc	p.R726H	CDHR1_ENST00000440770.2_Missense_Mutation_p.R430H|CDHR1_ENST00000332904.3_Intron	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	726					homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						ACCTTCTGGCGCAACAAGAAG	0.642000													4	180					0	0	1	0	0
TSSC2	0	broad.mit.edu	37	11	3427765	3427765	+	RNA	SNP	G	G	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr11:3427765G>C	ENST00000529482.1	+	0	882																											CACACGTCCTGCAGTGGCCTG	0.602000													4	91					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100170874	100170874	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr2:100170874C>T	ENST00000317233.4	-	23	3693	c.3458G>A	c.(3457-3459)cGc>cAc	p.R1153H	AFF3_ENST00000356421.2_Missense_Mutation_p.R1178H|AFF3_ENST00000409579.1_Missense_Mutation_p.R1178H|AFF3_ENST00000409236.1_Missense_Mutation_p.R1153H	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1153					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.R1178H(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						CTGGTGGATGCGCTGTGGGAT	0.632000													4	179					0	0	1	0	0
DKKL1	27120	broad.mit.edu	37	19	49867940	49867940	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr19:49867940G>A	ENST00000221498.2	+	2	517	c.112G>A	c.(112-114)Gcc>Acc	p.A38T	DKKL1_ENST00000594268.1_Intron	NM_014419.3	NP_055234.1	Q9UK85	DKKL1_HUMAN	dickkopf-like 1	38					anatomical structure morphogenesis	extracellular space	protein binding|signal transducer activity			large_intestine(2)|upper_aerodigestive_tract(1)	3		all_lung(116;1.66e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0456)		TGATGCTGACGCCCAAGAGAG	0.622000													22	86					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													6	129					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2143667	2143667	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr16:2143667C>T	ENST00000262304.4	-	37	11102	c.10894G>A	c.(10894-10896)Gag>Aag	p.E3632K	RP11-304L19.1_ENST00000570072.1_RNA|PKD1_ENST00000423118.1_Missense_Mutation_p.E3631K	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	3632			E -> D (in ADPKD1).		calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GCCGGGCTCTCTACCAGGGTG	0.642000													3	40					0	0	1	0	0
RALGAPB	57148	broad.mit.edu	37	20	37203492	37203492	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr20:37203492A>T	ENST00000262879.6	+	30	4651	c.4367A>T	c.(4366-4368)cAt>cTt	p.H1456L	RALGAPB_ENST00000490114.1_3'UTR|RALGAPB_ENST00000397042.3_Missense_Mutation_p.H1453L|RALGAPB_ENST00000397038.1_Missense_Mutation_p.H1235L|RALGAPB_ENST00000397040.1_Missense_Mutation_p.H1456L			Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit (non-catalytic)	1456					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(29)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AGTCCCCCCCATGTCCGCCGG	0.438000													14	219					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114082755	114082755	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chrX:114082755C>T	ENST00000276198.1	+	5	1267	c.539C>T	c.(538-540)gCa>gTa	p.A180V	HTR2C_ENST00000371950.3_Intron|HTR2C_ENST00000371951.1_Missense_Mutation_p.A180V	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	180					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	ATTGTTTGGGCAATTTCTATA	0.408000													27	155					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37686866	37686866	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr17:37686866C>G	ENST00000447079.4	+	14	3803	c.3770C>G	c.(3769-3771)cCt>cGt	p.P1257R	CDK12_ENST00000430627.2_Intron	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	1257					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						GCATGTCCTCCTCACATTCTT	0.512000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			12	492					0	0	1	0	0
HLA-C	3107	broad.mit.edu	37	6	31237284	31237284	+	Missense_Mutation	SNP	C	C	T	rs116968219	by1000genomes	TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr6:31237284C>T	ENST00000383329.3	-	6	1066	c.1052G>A	c.(1051-1053)tGc>tAc	p.C351Y	HLA-C_ENST00000376228.5_Missense_Mutation_p.C345Y			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	345					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						AGCCTGAGAGCAGCTCCCTCC	0.587000													4	88					0	0	1	0	0
CEP97	79598	broad.mit.edu	37	3	101484296	101484296	+	Silent	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr3:101484296C>T	ENST00000341893.3	+	11	3251	c.2499C>T	c.(2497-2499)agC>agT	p.S833S	CEP97_ENST00000494050.1_Silent_p.S774S|CEP97_ENST00000327230.4_Silent_p.S859S			Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	833						centrosome|nucleus	protein binding			cervix(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	29						GTGAAATTAGCCAGACACAAG	0.418000													5	412					0	0	1	0	0
SAP18	10284	broad.mit.edu	37	13	21721465	21721465	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr13:21721465G>A	ENST00000382533.4	+	4	542	c.503G>A	c.(502-504)cGc>cAc	p.R168H	SAP18_ENST00000607003.1_Missense_Mutation_p.R149H	NM_005870.4	NP_005861.2	O00422	SAP18_HUMAN	Sin3A-associated protein, 18kDa	149					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|plasma membrane	protein binding|transcription corepressor activity	p.R149H(1)		kidney(1)|large_intestine(1)|lung(4)	6		all_cancers(29;2.16e-20)|all_epithelial(30;2.97e-18)|all_lung(29;4.58e-16)|Lung SC(185;0.0262)|Breast(139;0.147)		all cancers(112;9.79e-05)|Epithelial(112;0.000292)|OV - Ovarian serous cystadenocarcinoma(117;0.00276)|Lung(94;0.0941)		CCTTCAGGGCGCATGAGACCA	0.403000													5	324					0	0	1	0	0
ZNF320	162967	broad.mit.edu	37	19	53384108	53384108	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr19:53384108C>T	ENST00000595635.1	-	8	1772	c.1271G>A	c.(1270-1272)cGc>cAc	p.R424H	ZNF320_ENST00000600930.1_Intron|ZNF320_ENST00000391781.2_Missense_Mutation_p.R424H|ZNF320_ENST00000597909.1_Intron	NM_207333.2	NP_997216.2	A2RRD8	ZN320_HUMAN	zinc finger protein 320	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(4)|large_intestine(5)|liver(1)|lung(10)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(134;0.0534)		GTGTGATTTGCGAATGTAAAC	0.388000													4	165					0	0	1	0	0
GRIN2A	0	broad.mit.edu	37	16	10032029	10032029	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr16:10032029G>A	ENST00000396573.2	-	4	1103	c.794C>T	c.(793-795)aCg>aTg	p.T265M	GRIN2A_ENST00000330684.3_Missense_Mutation_p.T265M|GRIN2A_ENST00000396575.2_Missense_Mutation_p.T265M|GRIN2A_ENST00000535259.1_Missense_Mutation_p.T108M|GRIN2A_ENST00000566670.1_5'UTR|GRIN2A_ENST00000562109.1_Missense_Mutation_p.T265M|GRIN2A_ENST00000404927.2_Missense_Mutation_p.T265M	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	265					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding	p.T265M(1)		NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GATGAGCTCCGTGTTCCCAGA	0.552000													5	122					0	0	1	0	0
AVPR2	0	broad.mit.edu	37	X	153171401	153171401	+	Silent	SNP	G	G	A	rs143055328		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chrX:153171401G>A	ENST00000358927.2	+	3	650	c.441G>A	c.(439-441)gcG>gcA	p.A147A	AVPR2_ENST00000370049.1_Silent_p.A147A|AVPR2_ENST00000337474.5_Silent_p.A147A			P30518	V2R_HUMAN	arginine vasopressin receptor 2	147			A -> V (in dbSNP:rs5200).		activation of adenylate cyclase activity|excretion|G-protein signaling, coupled to cAMP nucleotide second messenger|hemostasis|positive regulation of gene expression|transmembrane transport|water transport	endoplasmic reticulum|endosome|Golgi apparatus|integral to plasma membrane	vasopressin receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	26	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)				Conivaptan(DB00872)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCATGCTGGCGTACCGCCATG	0.627000													14	159					0	0	1	0	0
PLD3	0	broad.mit.edu	37	19	40872763	40872763	+	Silent	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr19:40872763C>T	ENST00000409587.1	+	5	583	c.186C>T	c.(184-186)taC>taT	p.Y62Y	PLD3_ENST00000409419.1_Silent_p.Y62Y|PLD3_ENST00000409735.4_Silent_p.Y62Y|PLD3_ENST00000356508.5_Silent_p.Y62Y|PLD3_ENST00000409281.1_Silent_p.Y62Y			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	62					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			TATGGGAATACGGCGACTTGC	0.632000													4	185					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71351177	71351177	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chrX:71351177C>T	ENST00000545866.1	-	1	581	c.214G>A	c.(214-216)Gcg>Acg	p.A72T	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.A72T			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	72										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					TCACTGAGCGCGAACTCCAAG	0.597000													9	131					0	0	1	0	0
CCDC155	147872	broad.mit.edu	37	19	49898519	49898519	+	Missense_Mutation	SNP	G	G	A	rs62623430		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr19:49898519G>A	ENST00000447857.3	+	4	510	c.305G>A	c.(304-306)cGt>cAt	p.R102H		NM_144688.4	NP_653289.3	Q8N6L0	CC155_HUMAN	coiled-coil domain containing 155	102						integral to membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(10)|ovary(1)|stomach(1)	22						GTTGTCATGCGTGACTGGATT	0.552000													25	143					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S|FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													4	265					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106082571	106082571	+	Missense_Mutation	SNP	G	G	T	rs138021287		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chrX:106082571G>T	ENST00000357242.5	+	8	1411	c.1237G>T	c.(1237-1239)Gat>Tat	p.D413Y	TBC1D8B_ENST00000276175.3_Missense_Mutation_p.D407Y|TBC1D8B_ENST00000310452.2_Missense_Mutation_p.D413Y	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	413						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AGAGCCATCTGATAATTTTGA	0.378000													22	229					1.28384e-07	1.38573e-07	1	1	0
PACRGL	133015	broad.mit.edu	37	4	20715062	20715062	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr4:20715062C>T	ENST00000360916.5	+	7	900	c.509C>T	c.(508-510)tCg>tTg	p.S170L	PACRGL_ENST00000502374.1_Missense_Mutation_p.S117L|PACRGL_ENST00000538990.1_Missense_Mutation_p.S72L|PACRGL_ENST00000295290.8_Missense_Mutation_p.S170L|PACRGL_ENST00000502938.1_Intron|PACRGL_ENST00000444671.2_Missense_Mutation_p.S72L|PACRGL_ENST00000507634.1_Missense_Mutation_p.S170L|PACRGL_ENST00000503585.1_Missense_Mutation_p.S170L|PACRGL_ENST00000513459.1_Missense_Mutation_p.S117L	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	170							binding			endometrium(2)|lung(7)|prostate(1)	10						CAGGTCCATTCGGATGATGAA	0.428000													20	125					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942732	10942732	+	Silent	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr21:10942732G>A	ENST00000298232.7	-	12	1022	c.655C>T	c.(655-657)Cta>Tta	p.L219L	TPTE_ENST00000361285.4_Silent_p.L237L|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.L199L	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	237					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGAGGTCTAGGTCAAATCCA	0.323000													24	814					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112686117	112686117	+	Silent	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr9:112686117G>A	ENST00000448454.2	+	5	366	c.366G>A	c.(364-366)aaG>aaA	p.K122K	AKAP2_ENST00000555236.1_Silent_p.K120K|PALM2_ENST00000314527.4_Silent_p.K120K|AKAP2_ENST00000510514.5_Silent_p.K120K|PALM2_ENST00000483909.1_Silent_p.K120K|PALM2_ENST00000374531.2_Silent_p.K122K|PALM2-AKAP2_ENST00000374530.3_Silent_p.K120K|PALM2-AKAP2_ENST00000302798.7_Silent_p.K120K					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						AATCCTTCAAGGACTTTCAGA	0.418000													6	41					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141759688	141759688	+	Silent	SNP	T	T	C			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr7:141759688T>C	ENST00000475668.2	+	33	4035	c.3981T>C	c.(3979-3981)ccT>ccC	p.P1327P	MGAM_ENST00000549489.2_Silent_p.P1327P			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1327	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.P1327P(2)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGACACAGCCTTATCCTGCCT	0.463000													4	44					0	0	1	0	0
ARHGAP18	93663	broad.mit.edu	37	6	129963161	129963161	+	Missense_Mutation	SNP	C	C	T	rs143012976		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr6:129963161C>T	ENST00000368149.2	-	2	204	c.116G>A	c.(115-117)cGc>cAc	p.R39H		NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	39					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		GCCATATCTGCGACTGTAAAT	0.383000													5	236					0	0	1	0	0
PALM2	114299	broad.mit.edu	37	9	112686126	112686126	+	Missense_Mutation	SNP	G	G	C	rs141885294		TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr9:112686126G>C	ENST00000448454.2	+	5	375	c.375G>C	c.(373-375)caG>caC	p.Q125H	AKAP2_ENST00000555236.1_Missense_Mutation_p.Q123H|PALM2_ENST00000314527.4_Missense_Mutation_p.Q123H|AKAP2_ENST00000510514.5_Missense_Mutation_p.Q123H|PALM2_ENST00000483909.1_Missense_Mutation_p.Q123H|PALM2_ENST00000374531.2_Missense_Mutation_p.Q125H|PALM2-AKAP2_ENST00000374530.3_Missense_Mutation_p.Q123H|PALM2-AKAP2_ENST00000302798.7_Missense_Mutation_p.Q123H					paralemmin 2											breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	18						AGGACTTTCAGAAGGTGAAGA	0.413000													5	35					0	0	1	0	0
NUP85	79902	broad.mit.edu	37	17	73204634	73204634	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr17:73204634G>A	ENST00000245544.4	+	2	117	c.46G>A	c.(46-48)Gtg>Atg	p.V16M	NUP85_ENST00000449421.2_Intron|NUP85_ENST00000447371.2_5'UTR|NUP85_ENST00000541827.1_Intron|NUP85_ENST00000579324.1_Intron|NUP85_ENST00000579298.1_Missense_Mutation_p.V16M	NM_024844.3	NP_079120.1	Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	16					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GATTCCAGGCGTGAATTCCAA	0.333000													5	552					0	0	1	0	0
KMT2E	55904	broad.mit.edu	37	7	104722169	104722174	+	In_Frame_Del	DEL	TTTATA	TTTATA	-			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr7:104722169_104722174delTTTATA	ENST00000334877.4	+	13	1817_1822	c.1283_1288delTTTATA	c.(1282-1290)ctt>c	p.LYI428del	KMT2E_ENST00000476671.1_In_Frame_Del_p.LYI428del|KMT2E_ENST00000257745.4_In_Frame_Del_p.LYI428del|KMT2E_ENST00000311117.3_In_Frame_Del_p.LYI428del|KMT2E_ENST00000334914.7_5'UTR					lysine (K)-specific methyltransferase 2E																		ACCATACATCTTTATATTTATTCTAT	0.306													20	166	---	---	---	---					
TRBV29-1	0	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													9	12	---	---	---	---					
LGR4	55366	broad.mit.edu	37	11	27398748	27398749	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr11:27398748_27398749delTT	ENST00000379214.4	-	12	1508_1509	c.1065_1066delAA	c.(1063-1068)atgafs	p.IR355fs	LGR4_ENST00000389858.4_Frame_Shift_Del_p.IR331fs	NM_018490.2	NP_060960.2	Q9BXB1	LGR4_HUMAN	leucine-rich repeat containing G protein-coupled receptor 4	355						integral to membrane|plasma membrane	protein-hormone receptor activity			NS(3)|breast(2)|endometrium(3)|kidney(2)|large_intestine(11)|lung(10)|ovary(1)	32						GGAAGGTCTCTTATATTATTGT	0.332													25	187	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45754101	45754103	+	RNA	DEL	CAC	CAC	-			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr15:45754101_45754103delCAC	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000560647.1_RNA|RP11-519G16.3_ENST00000558536.1_RNA																							atcacaccatcaccaccaccacc	0.571													2	4	---	---	---	---					
PDILT	204474	broad.mit.edu	37	16	20370700	20370702	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-S9-A6WI-01A-21D-A33T-08	TCGA-S9-A6WI-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	94f85240-c7fa-4026-b140-a777f230e3c9	b796628d-4a83-41f2-a924-33daf125d626	g.chr16:20370700_20370702delCCA	ENST00000302451.4	-	12	1942_1944	c.1694_1696delTGG	c.(1693-1698)gct>g	p.VA565del		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	565					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						TTTGGCTTAGCCACCACCACCAC	0.478													13	562	---	---	---	---