Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KRT15	3866	broad.mit.edu	37	17	39673194	39673194	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr17:39673194G>A	ENST00000254043.3	-	3	4189	c.604C>T	c.(604-606)Cgc>Tgc	p.R202C	KRT15_ENST00000393974.3_Missense_Mutation_p.R37C|KRT15_ENST00000393981.3_Missense_Mutation_p.R37C|KRT15_ENST00000393976.2_Missense_Mutation_p.R202C	NM_002275.3	NP_002266.2	P19012	K1C15_HUMAN	keratin 15	202	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16		Breast(137;0.000286)				ACGCCCTGGCGCAGGGCCAGC	0.597000													23	80					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349693	100349693	+	RNA	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:100349693C>T	ENST00000542585.1	+	0	2113				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AAAAACCCACCGTCCCCACAG	0.517000													34	152					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502322	20502322	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr14:20502322A>G	ENST00000315693.2	-	1	597	c.596T>C	c.(595-597)gTc>gCc	p.V199A		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GTCAGCAATGACCAGGAGCTG	0.488000													5	70					0	0	1	0	0
CDCA7L	55536	broad.mit.edu	37	7	21948089	21948089	+	Missense_Mutation	SNP	A	A	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:21948089A>C	ENST00000406877.3	-	4	619	c.340T>G	c.(340-342)Tct>Gct	p.S114A	CDCA7L_ENST00000465490.1_5'UTR|CDCA7L_ENST00000373934.4_Missense_Mutation_p.S68A|CDCA7L_ENST00000356195.5_Missense_Mutation_p.S80A	NM_018719.4	NP_061189.2	Q96GN5	CDA7L_HUMAN	cell division cycle associated 7-like	114	PSIP1-binding.				positive regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	29						CTCACCAAAGATGCTTTGCCA	0.418000													9	91					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161239	43161239	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr21:43161239G>A	ENST00000352483.2	-	9	2322	c.2258C>T	c.(2257-2259)aCg>aTg	p.T753M	RIPK4_ENST00000542057.1_Missense_Mutation_p.T642M|AP001615.9_ENST00000423276.1_RNA|RIPK4_ENST00000332512.3_Missense_Mutation_p.T705M|RIPK4_ENST00000544709.1_Missense_Mutation_p.T642M			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	705						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GTGCAGCGCCGTCTGGTTCAG	0.677000													8	126					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5463794	5463794	+	Silent	SNP	T	T	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr5:5463794T>A	ENST00000296564.7	+	13	4569	c.4347T>A	c.(4345-4347)ccT>ccA	p.P1449P		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	1449										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						GAGACATCCCTATTTCTCAGG	0.522000													8	73					0	0	1	0	0
CCNF	899	broad.mit.edu	37	16	2498903	2498903	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr16:2498903C>T	ENST00000397066.4	+	11	1230	c.1142C>T	c.(1141-1143)aCg>aTg	p.T381M		NM_001761.2	NP_001752.2	P41002	CCNF_HUMAN	cyclin F	381	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(2)|lung(5)|prostate(4)|skin(1)	20		Ovarian(90;0.17)				GTATGGCTCACGGACAACACT	0.557000													4	110					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678561	100678561	+	Silent	SNP	G	G	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:100678561G>T	ENST00000306151.4	+	3	3928	c.3864G>T	c.(3862-3864)acG>acT	p.T1288T		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1288	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.T1288T(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAGCACCACGCTGGTGACCA	0.473000													7	744					6.94344e-10	7.14183e-10	1	1	0
ZNF479	90827	broad.mit.edu	37	7	57194409	57194409	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:57194409C>G	ENST00000331162.4	-	3	326	c.56G>C	c.(55-57)aGa>aCa	p.R19T		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	19	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			AGCTATGTCTCTGAATGTCAA	0.413000													15	101					0	0	1	0	0
CD300C	10871	broad.mit.edu	37	17	72541027	72541027	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr17:72541027C>T	ENST00000330793.1	-	2	481	c.121G>A	c.(121-123)Gtg>Atg	p.V41M		NM_006678.3	NP_006669.1	Q08708	CLM6_HUMAN	CD300c molecule	41	Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(11)|skin(2)|upper_aerodigestive_tract(1)	21						CGACACTGCACACTCAGGGAT	0.537000													22	75					0	0	1	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184367380	184367380	+	Silent	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr4:184367380G>A	ENST00000504169.1	+	3	750	c.543G>A	c.(541-543)tcG>tcA	p.S181S	CDKN2AIP_ENST00000506835.1_3'UTR|CDKN2AIP_ENST00000302350.4_3'UTR	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	181	Ser-rich.				negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GTATAGGGTCGGCCATCAAAT	0.483000													4	64					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													5	125					0	0	1	0	0
ATF6B	1388	broad.mit.edu	37	6	32089121	32089121	+	Silent	SNP	G	G	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:32089121G>C	ENST00000375201.4	-	6	519	c.474C>G	c.(472-474)gtC>gtG	p.V158V	ATF6B_ENST00000375203.3_Silent_p.V161V			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	161					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						TCTTGGTCTGGACATCTGTGG	0.547000													10	20					0	0	1	0	0
CKMT1A	548596	broad.mit.edu	37	15	43990947	43990947	+	Nonsense_Mutation	SNP	C	C	T	rs150214356		TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr15:43990947C>T	ENST00000413453.2	+	8	1644	c.1120C>T	c.(1120-1122)Cga>Tga	p.R374*	CKMT1A_ENST00000434505.1_Nonsense_Mutation_p.R374*|STRC_ENST00000541030.1_Intron			P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1A	374	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			lung(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	TAATTTGGACCGACTAGGCAA	0.502000													19	64					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117739300	117739300	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chrX:117739300G>A	ENST00000276204.6	+	24	2736	c.2662G>A	c.(2662-2664)Gtt>Att	p.V888I	DOCK11_ENST00000276202.7_Missense_Mutation_p.V888I			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	888					blood coagulation	cytosol	GTP binding	p.V888I(1)		breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TGAAGATGACGTTCCTATCAA	0.348000													54	43					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72055540	72055540	+	Silent	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr14:72055540A>G	ENST00000555818.1	+	2	1299	c.951A>G	c.(949-951)cgA>cgG	p.R317R	SIPA1L1_ENST00000358550.2_Silent_p.R317R|SIPA1L1_ENST00000381232.3_Silent_p.R317R	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	317					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AAGATAACCGATCAGAAGACT	0.413000													18	59					0	0	1	0	0
CROCCP2	0	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													5	22					0	0	1	0	0
ALOX12	239	broad.mit.edu	37	17	6913672	6913672	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr17:6913672G>A	ENST00000251535.6	+	14	1975	c.1922G>A	c.(1921-1923)cGg>cAg	p.R641Q	AC027763.2_ENST00000574377.1_Intron|AC027763.2_ENST00000399540.2_Intron|AC027763.2_ENST00000399541.2_Intron|RP11-589P10.7_ENST00000572547.1_RNA|AC027763.2_ENST00000575727.1_Intron|AC027763.2_ENST00000573939.1_Intron	NM_000697.2	NP_000688.2	P18054	LOX12_HUMAN	arachidonate 12-lipoxygenase	641	Lipoxygenase.				anti-apoptosis|cellular component movement|fatty acid oxidation|leukotriene biosynthetic process|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of cell proliferation|superoxide anion generation	cytosol|sarcolemma	arachidonate 12-lipoxygenase activity|hepoxilin-epoxide hydrolase activity|iron ion binding|lipoxygenase activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)|urinary_tract(1)	19						ATTACAGCCCGGAATGAGCAA	0.473000													9	64					0	0	1	0	0
ANKRD30B	374860	broad.mit.edu	37	18	14791432	14791432	+	Silent	SNP	G	G	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr18:14791432G>C	ENST00000358984.4	+	16	1947	c.1767G>C	c.(1765-1767)gtG>gtC	p.V589V	ANKRD30B_ENST00000447268.2_Silent_p.V589V|ANKRD30B_ENST00000579292.1_Intron	NM_001145029.1	NP_001138501.1	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	589										breast(3)|endometrium(4)|kidney(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	22						AGAAGGATGTGTATTTACCCA	0.284000													16	50					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39645770	39645770	+	Splice_Site	SNP	T	T	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr8:39645770T>C	ENST00000265708.4	-	9	746	c.642_splice	c.e9-1	p.I215_splice	ADAM2_ENST00000347580.4_Splice_Site_p.I196_splice|ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000521880.1_Splice_Site_p.I215_splice	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	215	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		GAAACAAAAATCTAAAATAGA	0.239000													20	70					0	0	1	0	0
UGT2A1	10941	broad.mit.edu	37	4	70460268	70460268	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr4:70460268C>A	ENST00000503640.1	-	5	1286	c.1231G>T	c.(1231-1233)Gtg>Ttg	p.V411L	UGT2A1_ENST00000502343.1_5'UTR|UGT2A2_ENST00000457664.2_Missense_Mutation_p.V420L|UGT2A1_ENST00000512704.1_Missense_Mutation_p.V367L|UGT2A1_ENST00000286604.4_Missense_Mutation_p.V411L|UGT2A1_ENST00000514019.1_Missense_Mutation_p.V577L	NM_006798.3	NP_006789.2	Q9Y4X1	UD2A1_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus	411					detection of chemical stimulus|sensory perception of smell	integral to membrane	glucuronosyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(11)|ovary(2)|prostate(1)|skin(2)	30						TTCACTTCCACAGCTGCTCCT	0.443000													20	112					7.21436e-19	7.75275e-19	1	1	0
TRBV20-1	0	broad.mit.edu	37	7	142334679	142334679	+	RNA	SNP	A	A	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:142334679A>C	ENST00000390394.3	+	0	179																											ACCTCTGTGAAGATCGAGTGC	0.527000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	146					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70488940	70488940	+	Missense_Mutation	SNP	G	G	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr1:70488940G>T	ENST00000310961.5	+	18	1996	c.1578G>T	c.(1576-1578)caG>caT	p.Q526H	RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000035383.5_Missense_Mutation_p.Q521H|LRRC7_ENST00000415775.2_Intron			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	521						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCGTCCCCCAGAATGACCCAC	0.562000													19	60					1.01871e-10	1.063e-10	1	1	0
NCF1B	0	broad.mit.edu	37	7	72639953	72639953	+	RNA	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:72639953G>A	ENST00000423083.1	+	0	158					NR_003186.1																						GCGGGCCGCCGAGAACCACCA	0.637000													13	37					0	0	1	0	0
LTBP1	4052	broad.mit.edu	37	2	33412100	33412100	+	Nonsense_Mutation	SNP	C	C	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr2:33412100C>G	ENST00000404816.2	+	6	1732	c.1379C>G	c.(1378-1380)tCa>tGa	p.S460*	LTBP1_ENST00000418533.2_Nonsense_Mutation_p.S134*|LTBP1_ENST00000404525.1_Nonsense_Mutation_p.S134*|LTBP1_ENST00000402934.1_Nonsense_Mutation_p.S134*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.S134*|LTBP1_ENST00000354476.3_Nonsense_Mutation_p.S460*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.S134*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	460					negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GTCATCCATTCAACACATACC	0.512000													10	46					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628251	29628251	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr20:29628251A>G	ENST00000278882.3	+	6	633	c.253A>G	c.(253-255)Aat>Gat	p.N85D	FRG1B_ENST00000439954.2_Missense_Mutation_p.N90D|FRG1B_ENST00000358464.4_Missense_Mutation_p.N85D														p.N85D(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTGGCCTCAAATAGCTGCTT	0.358000													10	174					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123151111	123151111	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr4:123151111G>A	ENST00000264501.4	+	26	3441	c.3068G>A	c.(3067-3069)tGt>tAt	p.C1023Y	KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000388738.3_Missense_Mutation_p.C1023Y|KIAA1109_ENST00000455637.1_Missense_Mutation_p.C1023Y			Q2LD37	K1109_HUMAN	KIAA1109	1023					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GTTGCAAACTGTAATCTCCAC	0.343000													13	49					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55406633	55406633	+	Splice_Site	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:55406633A>G	ENST00000398661.2	-	4	412	c.279_splice	c.e4-1	p.V94_splice	HMGCLL1_ENST00000308161.4_Splice_Site_p.V64_splice|HMGCLL1_ENST00000428842.1_Splice_Site_p.V64_splice|HMGCLL1_ENST00000370850.2_Splice_Site_p.V64_splice|HMGCLL1_ENST00000508459.1_Splice_Site_p.V64_splice|HMGCLL1_ENST00000274901.4_Splice_Site_p.V64_splice	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	94							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGGAACTATAACCTATGAAAA	0.294000													26	89					0	0	1	0	0
NAA25	80018	broad.mit.edu	37	12	112499080	112499080	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr12:112499080G>A	ENST00000261745.4	-	12	1510	c.1262C>T	c.(1261-1263)aCg>aTg	p.T421M		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	421						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						AAGTAACCTCGTCAGCTGCAC	0.463000													7	35					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													4	163					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52532038	52532038	+	Silent	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr15:52532038G>A	ENST00000261839.7	-	21	2756	c.2595C>T	c.(2593-2595)taC>taT	p.Y865Y	MYO5C_ENST00000443683.2_Intron	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	865	IQ 5.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		ACGCCCGTGCGTATTTCTGTA	0.453000													27	63					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													5	126					0	0	1	0	0
CSN3	1448	broad.mit.edu	37	4	71114860	71114860	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr4:71114860G>A	ENST00000304954.3	+	4	319	c.233G>A	c.(232-234)cGc>cAc	p.R78H		NM_005212.2	NP_005203.2	P07498	CASK_HUMAN	casein kappa	78						extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						TATGTGCCTCGCACATATTAT	0.448000													16	43					0	0	1	0	0
EPM2AIP1	9852	broad.mit.edu	37	3	37032873	37032873	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr3:37032873G>A	ENST00000322716.5	-	1	1922	c.1696C>T	c.(1696-1698)Cga>Tga	p.R566*		NM_014805.3	NP_055620.1	Q7L775	EPMIP_HUMAN	EPM2A (laforin) interacting protein 1	566						endoplasmic reticulum				breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(12)|ovary(2)	27						TGTTGGTTTCGAGTCAAATAT	0.453000													26	69					0	0	1	0	0
PCM1	5108	broad.mit.edu	37	8	17823519	17823519	+	Missense_Mutation	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr8:17823519A>G	ENST00000325083.8	+	19	3306	c.2867A>G	c.(2866-2868)aAt>aGt	p.N956S	PCM1_ENST00000524226.1_Missense_Mutation_p.N957S|PCM1_ENST00000519253.1_Missense_Mutation_p.N956S	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	956					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		TGGAAGAACAATTGCCCTTTT	0.388000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								6	30					0	0	1	0	0
RRBP1	6238	broad.mit.edu	37	20	17602584	17602584	+	Silent	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr20:17602584C>T	ENST00000377813.1	-	14	3459	c.3156G>A	c.(3154-3156)tcG>tcA	p.S1052S	RRBP1_ENST00000360807.4_Silent_p.S619S|RRBP1_ENST00000246043.4_Silent_p.S1052S|RRBP1_ENST00000455029.2_Silent_p.S393S|RRBP1_ENST00000377807.2_Silent_p.S619S			Q9P2E9	RRBP1_HUMAN	ribosome binding protein 1	1052					protein transport|translation|transmembrane transport	integral to endoplasmic reticulum membrane|ribosome	receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(6)	28						GCTGCTTCTCCGATTCCTCCT	0.617000													5	58					0	0	1	0	0
IL17F	112744	broad.mit.edu	37	6	52101833	52101833	+	Missense_Mutation	SNP	C	C	T	rs141798304	byFrequency	TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:52101833C>T	ENST00000336123.4	-	3	495	c.388G>A	c.(388-390)Gtc>Atc	p.V130I		NM_052872.3	NP_443104.1	Q96PD4	IL17F_HUMAN	interleukin 17F	130					cartilage development|inflammatory response|lymphotoxin A biosynthetic process|negative regulation of angiogenesis|proteoglycan metabolic process|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of interleukin-6 biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|cytokine binding|protein homodimerization activity			NS(1)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)	14	Lung NSC(77;0.116)					TTCCTCCGGACGACCAGGGTC	0.542000													8	44					0	0	1	0	0
GTF2IRD2P1	0	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													4	96					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131211436	131211436	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:131211436C>G	ENST00000337057.3	-	11	1839	c.1658G>C	c.(1657-1659)gGa>gCa	p.G553A	EPB41L2_ENST00000525271.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000527659.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000530481.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000445890.2_Missense_Mutation_p.G553A|EPB41L2_ENST00000529208.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000528282.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000525193.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000368128.2_Missense_Mutation_p.G553A|EPB41L2_ENST00000527411.1_Missense_Mutation_p.G553A|EPB41L2_ENST00000392427.3_Missense_Mutation_p.G553A	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	553	Hydrophilic.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		GTGTTTACCTCCATCTAGACT	0.448000													26	132					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37029461	37029461	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chrX:37029461T>C	ENST00000358047.3	+	1	3030	c.2978T>C	c.(2977-2979)aTg>aCg	p.M993T		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	993										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGCTATGAAATGCCTGGCATC	0.438000													40	62					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281967	152281967	+	Missense_Mutation	SNP	C	C	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr1:152281967C>A	ENST00000368799.1	-	3	5430	c.5395G>T	c.(5395-5397)Gac>Tac	p.D1799Y	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1799	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTGTCTCGTGCCTGC	0.602000									Ichthyosis				56	412					5.47352e-35	5.97112e-35	1	1	0
IL18RAP	8807	broad.mit.edu	37	2	103061723	103061723	+	Missense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr2:103061723G>A	ENST00000264260.2	+	9	1584	c.995G>A	c.(994-996)cGc>cAc	p.R332H	IL18RAP_ENST00000409369.1_Missense_Mutation_p.R190H	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	332	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						CGTGATCTTCGCAGGAAGTTT	0.423000													4	78					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045508	53045508	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr12:53045508C>T	ENST00000309680.3	-	1	440	c.419G>A	c.(418-420)gGc>gAc	p.G140D		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	140	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		AGGCCCAAAGCCACCAGGACC	0.592000													22	45					0	0	1	0	0
FAM71F2	346653	broad.mit.edu	37	7	128317737	128317737	+	Missense_Mutation	SNP	T	T	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:128317737T>C	ENST00000480462.1	+	3	591	c.485T>C	c.(484-486)aTt>aCt	p.I162T	FAM71F2_ENST00000460349.1_3'UTR|FAM71F2_ENST00000477515.1_Intron|FAM71F2_ENST00000378704.3_Missense_Mutation_p.I153T			Q6NXP2	F71F2_HUMAN	family with sequence similarity 71, member F2	162										NS(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(2)	7						CACCCAGAGATTGTGTTTCAA	0.507000													7	113					0	0	1	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30688392	30688392	+	Missense_Mutation	SNP	G	G	C			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr22:30688392G>C	ENST00000215790.7	-	9	1663	c.1499C>G	c.(1498-1500)tCc>tGc	p.S500C	TBC1D10A_ENST00000403362.1_Missense_Mutation_p.S412C|TBC1D10A_ENST00000403477.3_Missense_Mutation_p.S507C|RP1-130H16.18_ENST00000447976.1_Intron	NM_031937.2	NP_114143.1	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	500						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			cervix(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						ACTCTCTTGGGACGTCAAGCT	0.592000													55	144					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43591856	43591856	+	Silent	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:43591856C>T	ENST00000395891.1	+	28	5036	c.4431C>T	c.(4429-4431)gcC>gcT	p.A1477A	HECW1_ENST00000453890.1_Silent_p.A1443A	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1477	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TGTTTGATGCCAGGGAGCTGG	0.517000													13	89					0	0	1	0	0
RP11-204M4.2	0	broad.mit.edu	37	9	41962666	41962666	+	RNA	SNP	T	T	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr9:41962666T>G	ENST00000454645.1	-	0	838					NR_003670.1																						CCTCCGTTGTTTGTCCATTTA	0.358000													6	49					0	0	1	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36147303	36147303	+	Nonsense_Mutation	SNP	C	C	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr14:36147303C>A	ENST00000258840.6	-	22	3490	c.3100G>T	c.(3100-3102)Gaa>Taa	p.E1034*	RALGAPA1_ENST00000382366.3_Nonsense_Mutation_p.E1000*|RALGAPA1_ENST00000389698.3_Nonsense_Mutation_p.E987*|RALGAPA1_ENST00000307138.6_Nonsense_Mutation_p.E987*			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	987					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAAGCACTTTCTGAACCTGTA	0.373000													11	18					1.5842e-08	1.60651e-08	1	1	0
AGAP2	116986	broad.mit.edu	37	12	58135803	58135803	+	Nonsense_Mutation	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr12:58135803G>A	ENST00000257897.3	-	1	137	c.52C>T	c.(52-54)Cga>Tga	p.R18*	TSPAN31_ENST00000553221.1_Intron	NM_014770.3	NP_055585.1	Q99490	AGAP2_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0	Interaction with EPB41L1 (By similarity).				axon guidance|negative regulation of neuron apoptosis|negative regulation of protein catabolic process|protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	mitochondrion|nucleolus	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|large_intestine(7)|lung(20)|prostate(3)|skin(1)|stomach(1)	48						ACCTCATGTCGTCTGACTTCT	0.592000													403	112					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131211508	131211508	+	Missense_Mutation	SNP	C	C	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:131211508C>G	ENST00000337057.3	-	11	1767	c.1586G>C	c.(1585-1587)aGc>aCc	p.S529T	EPB41L2_ENST00000525271.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000527659.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000530481.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000445890.2_Missense_Mutation_p.S529T|EPB41L2_ENST00000529208.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000528282.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000525193.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000368128.2_Missense_Mutation_p.S529T|EPB41L2_ENST00000527411.1_Missense_Mutation_p.S529T|EPB41L2_ENST00000392427.3_Missense_Mutation_p.S529T	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	529	Hydrophilic.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TATGAGGGTGCTGGCCTGGCG	0.507000													29	117					0	0	1	0	0
GRIN1	2902	broad.mit.edu	37	9	140040319	140040319	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr9:140040319C>T	ENST00000371561.3	+	3	1632	c.535C>T	c.(535-537)Cgc>Tgc	p.R179C	GRIN1_ENST00000371546.4_Missense_Mutation_p.R179C|GRIN1_ENST00000371555.4_Missense_Mutation_p.R179C|GRIN1_ENST00000315048.3_Missense_Mutation_p.R179C|GRIN1_ENST00000371560.3_Missense_Mutation_p.R179C|GRIN1_ENST00000371550.4_Missense_Mutation_p.R179C|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371559.4_Missense_Mutation_p.R179C|GRIN1_ENST00000350902.5_Missense_Mutation_p.R179C|GRIN1_ENST00000371553.3_Missense_Mutation_p.R179C	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	179					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GGCTCAGAAACGCCTGGAGAC	0.672000													4	5					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49723994	49723994	+	Missense_Mutation	SNP	A	A	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr5:49723994A>T	ENST00000303221.5	-	2	395	c.180T>A	c.(178-180)caT>caA	p.H60Q	EMB_ENST00000514111.1_Missense_Mutation_p.H10Q|EMB_ENST00000508934.1_Missense_Mutation_p.H60Q|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	60						integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				GTGATATGTTATGACTCTCCA	0.328000													10	46					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214556732	214556732	+	Missense_Mutation	SNP	T	T	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr1:214556732T>A	ENST00000366956.5	-	13	2660	c.2466A>T	c.(2464-2466)aaA>aaT	p.K822N	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	822					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TCACAGGCTCTTTTTTGACCC	0.552000													11	74					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80646694	80646694	+	Silent	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr16:80646694G>A	ENST00000299564.8	-	5	1202	c.1047C>T	c.(1045-1047)atC>atT	p.I349I	CDYL2_ENST00000563890.1_Silent_p.I350I|CDYL2_ENST00000562812.1_Silent_p.I350I|CDYL2_ENST00000566173.1_Silent_p.I350I	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	349						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						TGGCCACCACGATAGGCTTCT	0.567000													15	54					0	0	1	0	0
FSTL1	11167	broad.mit.edu	37	3	120123741	120123741	+	Silent	SNP	A	A	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr3:120123741A>G	ENST00000295633.3	-	7	896	c.540T>C	c.(538-540)aaT>aaC	p.N180N	FSTL1_ENST00000424703.2_Silent_p.N145N	NM_007085.4	NP_009016.1	Q12841	FSTL1_HUMAN	follistatin-like 1	180					BMP signaling pathway	extracellular space	calcium ion binding|heparin binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(1)	20				GBM - Glioblastoma multiforme(114;0.189)		ACGTTGTAATATTGATGGCAG	0.453000													24	76					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	100990160	100990160	+	Silent	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr8:100990160G>A	ENST00000360863.6	-	23	3698	c.3504C>T	c.(3502-3504)gaC>gaT	p.D1168D	RGS22_ENST00000523287.1_Silent_p.D987D|RGS22_ENST00000523437.1_Silent_p.D1156D	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1168					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CAGATTTTTCGTCTTCTAGGA	0.303000													21	48					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55210075	55210075	+	Missense_Mutation	SNP	T	T	G			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:55210075T>G	ENST00000275493.2	+	2	362	c.185T>G	c.(184-186)cTt>cGt	p.L62R	EGFR_ENST00000442591.1_Missense_Mutation_p.L62R|EGFR_ENST00000342916.3_Missense_Mutation_p.L62R|EGFR_ENST00000344576.2_Missense_Mutation_p.L62R|EGFR_ENST00000454757.2_Missense_Mutation_p.L9R|EGFR_ENST00000420316.2_Missense_Mutation_p.L62R|EGFR_ENST00000455089.1_Missense_Mutation_p.L62R	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	62					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L62R(3)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGGTGGTCCTTGGGAATTTG	0.408000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			38	118					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	69					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S163S|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								6	114					0	0	1	0	0
RP11-204M4.2	0	broad.mit.edu	37	9	41962661	41962661	+	RNA	SNP	G	G	A			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr9:41962661G>A	ENST00000454645.1	-	0	843					NR_003670.1																						TTTCCCCTCCGTTGTTTGTCC	0.368000													5	59					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131211445	131211445	+	Missense_Mutation	SNP	C	C	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:131211445C>T	ENST00000337057.3	-	11	1830	c.1649G>A	c.(1648-1650)aGt>aAt	p.S550N	EPB41L2_ENST00000525271.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000527659.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000530481.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000445890.2_Missense_Mutation_p.S550N|EPB41L2_ENST00000529208.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000528282.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000525193.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000368128.2_Missense_Mutation_p.S550N|EPB41L2_ENST00000527411.1_Missense_Mutation_p.S550N|EPB41L2_ENST00000392427.3_Missense_Mutation_p.S550N	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	550	Hydrophilic.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TCCATCTAGACTCCTGGAGAC	0.453000													29	137					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433374	55433374	+	Silent	SNP	G	G	T			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr11:55433374G>T	ENST00000314259.3	+	1	761	c.732G>T	c.(730-732)gtG>gtT	p.V244V		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						ACCTCACGGTGGTTGTATTGT	0.502000													47	133					6.23363e-37	6.90495e-37	1	1	0
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	T	-			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr4:15995680delT	ENST00000505450.1	-	15	2282	c.1670delA	c.(1669-1671)atfs	p.N557fs	PROM1_ENST00000540805.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000510224.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000539194.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000543373.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000508167.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000447510.2_Frame_Shift_Del_p.N566fs	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	566					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AGTGCCTCTATTTTTTTTGCA	0.428													7	111	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100261040	100261041	+	RNA	INS	-	-	A	rs138827617	by1000genomes	TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr4:100261040_100261041insA	ENST00000515683.1	-	0	1316					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AGTGCTTTCACAAAAAAAATCA	0.327													5	2	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	GCCGGG	-	rs60664426		TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr6:42989414_42989419delGCCGGG	ENST00000244496.5	+	1	32_37	c.22_27delGCCGGG	c.(22-27)del	p.AG14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus		p.A8_G9delAG(2)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TAACTAccgcgccggggccggggccg	0.777													4	4	---	---	---	---					
TNRC18	84629	broad.mit.edu	37	7	5430008	5430011	+	Frame_Shift_Del	DEL	AAAG	AAAG	-	rs34840801		TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr7:5430008_5430011delAAAG	ENST00000399434.2	-	3	528_531	c.370_373delCTTT	c.(370-375)ttfs	p.LF124fs	TNRC18_ENST00000399537.4_Intron|TNRC18_ENST00000430969.1_Intron			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	0							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		aaaaaaaaaaaaaGCCAGCATCCT	0.544													3	6	---	---	---	---					
NPIPA8	101059953	broad.mit.edu	37	16	18441114	18441116	+	Splice_Site	DEL	CAC	CAC	-			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr16:18441114_18441116delCAC	ENST00000339303.5	-	1	15		c.e1+1							nuclear pore complex interacting protein family, member A8																		CGGCCATACTCACCACTGGGACT	0.709													5	10	---	---	---	---					
SNX29P2	0	broad.mit.edu	37	16	29269502	29269502	+	RNA	DEL	C	C	-			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr16:29269502delC	ENST00000398878.3	+	0	214																											ACAAGCCCTTCCCGGGCTGGA	0.577													2	4	---	---	---	---					
CTB-58E17.3	0	broad.mit.edu	37	17	36861701	36861703	+	RNA	DEL	GAG	GAG	-			TCGA-S9-A7R2-01A-21D-A34J-08	TCGA-S9-A7R2-10A-01D-A34M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8a5cf4b7-7bf9-4246-bb02-4490457998e8	c60fce17-9f90-426d-ac1f-8a0faa38b361	g.chr17:36861701_36861703delGAG	ENST00000583409.1	-	0	208																											CAGAGCGAGCgaggaggaggagg	0.734													2	4	---	---	---	---