Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
INO80B	83444	broad.mit.edu	37	2	74682565	74682565	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:74682565C>T	ENST00000233331.7	+	2	185	c.91C>T	c.(91-93)Cat>Tat	p.H31Y	INO80B_ENST00000469849.1_Intron|INO80B_ENST00000409917.1_Missense_Mutation_p.H31Y	NM_031288.3	NP_112578.2	Q9C086	IN80B_HUMAN	INO80 complex subunit B	31					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex|nucleolus	metal ion binding|protein binding			endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	13						GGCGGGTGCCCATGGCCATGG	0.567000													16	42					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	42058595	42058595	+	Missense_Mutation	SNP	A	A	C			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr15:42058595A>C	ENST00000219905.7	+	24	8496	c.8315A>C	c.(8314-8316)gAt>gCt	p.D2772A	MGA_ENST00000389936.4_Missense_Mutation_p.D2733A|MGA_ENST00000570161.1_Missense_Mutation_p.D2772A|MGA_ENST00000566586.1_Missense_Mutation_p.D2563A|MGA_ENST00000545763.1_Missense_Mutation_p.D2563A	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2733						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AAGTCAAAGGATTCTTCATTT	0.378000													3	12					0	0	1	0	0
RIPK4	54101	broad.mit.edu	37	21	43161344	43161344	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr21:43161344C>T	ENST00000352483.2	-	9	2217	c.2153G>A	c.(2152-2154)gGc>gAc	p.G718D	RIPK4_ENST00000544709.1_Missense_Mutation_p.G607D|RIPK4_ENST00000332512.3_Missense_Mutation_p.G670D|RIPK4_ENST00000542057.1_Missense_Mutation_p.G607D|AP001615.9_ENST00000423276.1_RNA			Q96T11	Q96T11_HUMAN	receptor-interacting serine-threonine kinase 4	670						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						AGCGGTGTAGCCGTCTGAGGT	0.682000													20	45					0	0	1	0	0
INPP4B	8821	broad.mit.edu	37	4	143326450	143326450	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr4:143326450C>T	ENST00000513000.1	-	7	597	c.164G>A	c.(163-165)cGt>cAt	p.R55H	INPP4B_ENST00000509777.1_Missense_Mutation_p.R55H|INPP4B_ENST00000506217.1_Missense_Mutation_p.R55H|INPP4B_ENST00000308502.4_Missense_Mutation_p.R55H|INPP4B_ENST00000508116.1_Missense_Mutation_p.R55H|INPP4B_ENST00000262992.4_Missense_Mutation_p.R55H	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	55	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					TTTACGATCACGGACAGGAGC	0.517000													12	17					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55118674	55118674	+	Silent	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr1:55118674G>A	ENST00000414150.2	+	3	353	c.75G>A	c.(73-75)ggG>ggA	p.G25G	MROH7_ENST00000339553.5_Silent_p.G25G|MROH7_ENST00000545244.1_Intron|MROH7_ENST00000472987.1_3'UTR|MROH7_ENST00000454855.2_Intron|MROH7_ENST00000421030.2_Silent_p.G25G|MROH7_ENST00000409996.1_Intron|MROH7_ENST00000395690.2_Silent_p.G25G					maestro heat-like repeat family member 7																		CCTCCTGTGGGGCCCCGGGAT	0.592000													22	15					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18025715	18025715	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr17:18025715C>T	ENST00000205890.5	+	2	3939	c.3601C>T	c.(3601-3603)Cgg>Tgg	p.R1201W		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	1201	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					GCCAAGCTGGCGGAACAAGGT	0.632000													11	22					0	0	1	0	0
MAP3K5	4217	broad.mit.edu	37	6	136882674	136882674	+	Silent	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr6:136882674G>A	ENST00000359015.4	-	28	4344	c.3984C>T	c.(3982-3984)agC>agT	p.S1328S	MAP3K5_ENST00000355845.4_Silent_p.S575S	NM_005923.3	NP_005914.1	Q99683	M3K5_HUMAN	mitogen-activated protein kinase kinase kinase 5	1328					activation of JUN kinase activity|activation of MAPKK activity|cellular response to hydrogen peroxide|induction of apoptosis by extracellular signals|interspecies interaction between organisms		ATP binding|caspase activator activity|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein phosphatase binding			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(6)|large_intestine(6)|lung(24)|ovary(2)|prostate(1)|skin(4)|urinary_tract(4)	58	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00137)|OV - Ovarian serous cystadenocarcinoma(155;0.00569)		TCTTTACCCGGCTTATAGTGT	0.433000													3	48					0	0	1	0	0
VEZT	55591	broad.mit.edu	37	12	95694120	95694120	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr12:95694120G>A	ENST00000436874.1	+	12	2116	c.2011G>A	c.(2011-2013)Ggt>Agt	p.G671S	VEZT_ENST00000261219.6_Missense_Mutation_p.G623S|VEZT_ENST00000356859.4_3'UTR	NM_017599.3	NP_060069.3	Q9HBM0	VEZA_HUMAN	vezatin, adherens junctions transmembrane protein	671						acrosomal vesicle|adherens junction|integral to membrane|nucleus				endometrium(2)|kidney(3)|large_intestine(1)|lung(14)|ovary(2)|upper_aerodigestive_tract(1)	23						CTCTCTAGAAGGTAAAAATAA	0.353000													6	8					0	0	1	0	0
C14orf105	55195	broad.mit.edu	37	14	57960220	57960220	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr14:57960220A>G	ENST00000216445.3	-	1	350	c.214T>C	c.(214-216)Tat>Cat	p.Y72H	C14orf105_ENST00000534126.1_Missense_Mutation_p.Y72H|C14orf105_ENST00000526336.1_Missense_Mutation_p.Y72H|C14orf105_ENST00000422976.2_Missense_Mutation_p.Y72H	NM_018168.2	NP_060638.2	Q9NVL8	CN105_HUMAN	chromosome 14 open reading frame 105	72										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)|skin(1)	11						CCTGTAGAATATCTTCCATAC	0.408000													26	32					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79581312	79581312	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr10:79581312T>C	ENST00000372391.2	-	15	2935	c.2930A>G	c.(2929-2931)aAc>aGc	p.N977S	DLG5_ENST00000372388.2_Intron	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	977					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TTTGAAAGTGTTAGGGTCAAA	0.577000													11	57					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65847524	65847524	+	Silent	SNP	C	C	T	rs140600679		TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr12:65847524C>T	ENST00000308259.5	+	6	583	c.309C>T	c.(307-309)caC>caT	p.H103H	MSRB3_ENST00000535664.1_Silent_p.H103H|MSRB3_ENST00000540804.1_Silent_p.H110H|MSRB3_ENST00000355192.3_Silent_p.H110H	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	110					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		CTTCATTCCACGATGTGATCA	0.448000													20	24					0	0	1	0	0
RP11-1166P10.8	0	broad.mit.edu	37	16	32163807	32163807	+	RNA	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr16:32163807G>A	ENST00000564145.1	-	0	27																											GTGGGTGATGGAGCGGAGCTG	0.527000													9	19					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106157155	106157155	+	Nonsense_Mutation	SNP	A	A	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr4:106157155A>T	ENST00000513237.1	+	3	2916	c.2119A>T	c.(2119-2121)Aga>Tga	p.R707*	TET2_ENST00000380013.4_Nonsense_Mutation_p.R686*|TET2_ENST00000305737.2_Nonsense_Mutation_p.R686*|TET2_ENST00000394764.1_Nonsense_Mutation_p.R686*|TET2_ENST00000413648.2_Nonsense_Mutation_p.R686*|TET2_ENST00000545826.1_Nonsense_Mutation_p.R686*|TET2_ENST00000540549.1_Nonsense_Mutation_p.R686*			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	686	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.F683fs*17(1)|p.R686fs*7(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TTTTCAACAAAGAGCAGATTC	0.423000			"""Mis N, F"""		MDS								28	45					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000446179.1_Missense_Mutation_p.R132H|IDH1_ENST00000345146.2_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								18	30					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69554140	69554140	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:69554140T>C	ENST00000357308.4	-	19	2139	c.1961A>G	c.(1960-1962)aAg>aGg	p.K654R	GFPT1_ENST00000361060.4_Missense_Mutation_p.K636R	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	654	SIS 2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						GTGGGGCACCTTGATCGTTCT	0.473000													21	57					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109526915	109526915	+	Splice_Site	SNP	C	C	G			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:109526915C>G	ENST00000409271.1	-	9	1343		c.e9+1		EDAR_ENST00000258443.2_Splice_Site|EDAR_ENST00000376651.1_Splice_Site			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor						apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CTTCCACATACCTCTTGGTGG	0.577000													10	7					0	0	1	0	0
OR4C13	283092	broad.mit.edu	37	11	49974112	49974112	+	Silent	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr11:49974112C>T	ENST00000555099.1	+	1	170	c.138C>T	c.(136-138)acC>acT	p.T46T		NM_001001955.2	NP_001001955.2	Q8NGP0	OR4CD_HUMAN	olfactory receptor, family 4, subfamily C, member 13	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	43						TTGTGGTCACCATCACTGCCA	0.438000													49	85					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47394244	47394244	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr17:47394244C>T	ENST00000362063.2	-	2	1162	c.844G>A	c.(844-846)Gtc>Atc	p.V282I	ZNF652_ENST00000430262.2_Missense_Mutation_p.V282I	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	282					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CTTTCCAGGACAAACTTCTTG	0.453000													24	50					0	0	1	0	0
THUMPD2	80745	broad.mit.edu	37	2	39997066	39997066	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:39997066C>T	ENST00000505747.1	-	3	483	c.456G>A	c.(454-456)atG>atA	p.M152I	THUMPD2_ENST00000454352.2_Missense_Mutation_p.M122I|THUMPD2_ENST00000403537.3_5'UTR|THUMPD2_ENST00000260619.6_Missense_Mutation_p.M122I	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	152							methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				CTATCTTTTGCATTTGTTCTA	0.318000													10	22					0	0	1	0	0
SPDYE1	285955	broad.mit.edu	37	7	44046924	44046924	+	Missense_Mutation	SNP	C	C	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr7:44046924C>A	ENST00000258704.3	+	5	827	c.690C>A	c.(688-690)caC>caA	p.H230Q	AC004951.6_ENST00000447643.1_RNA|POLR2J4_ENST00000427076.1_RNA	NM_001099435.2|NM_175064.2	NP_001092905.2|NP_778234.2	Q8NFV5	SPDE1_HUMAN	speedy/RINGO cell cycle regulator family member E1	230										endometrium(1)|kidney(4)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	11						ACATCTTCCACTTCCTGTATG	0.557000													57	84					1.45723e-30	1.58581e-30	1	1	0
OSR2	116039	broad.mit.edu	37	8	99961351	99961351	+	Silent	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr8:99961351G>A	ENST00000297565.4	+	2	667	c.171G>A	c.(169-171)ggG>ggA	p.G57G	OSR2_ENST00000457907.2_Silent_p.G178G|OSR2_ENST00000522510.1_Silent_p.G57G|OSR2_ENST00000523368.1_Silent_p.G57G|OSR2_ENST00000435298.2_Silent_p.G57G	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	57					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			GGACGCTGGGGTATCCCAATG	0.657000													18	29					0	0	1	0	0
B3GALT1	8708	broad.mit.edu	37	2	168725943	168725943	+	Missense_Mutation	SNP	C	C	G			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:168725943C>G	ENST00000305861.1	+	2	745	c.394C>G	c.(394-396)Caa>Gaa	p.Q132E	B3GALT1_ENST00000392690.2_Missense_Mutation_p.Q132E|AC016723.4_ENST00000430546.1_RNA|AC016723.4_ENST00000436982.2_RNA	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	132					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						GATGGTGGAGCAAGAGAGCCA	0.478000													20	31					0	0	1	0	0
VIT	5212	broad.mit.edu	37	2	37035867	37035867	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr2:37035867C>T	ENST00000379242.3	+	15	1944	c.1642C>T	c.(1642-1644)Cgc>Tgc	p.R548C	VIT_ENST00000401530.1_Missense_Mutation_p.R512C|VIT_ENST00000497382.1_Missense_Mutation_p.R202C|VIT_ENST00000404084.1_Missense_Mutation_p.R485C|VIT_ENST00000389975.3_Missense_Mutation_p.R533C|VIT_ENST00000379241.3_Missense_Mutation_p.R511C	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	533	VWFA 2.					proteinaceous extracellular matrix		p.R548S(1)		autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				CACGGACACGCGCATCGGGGC	0.587000													19	20					0	0	1	0	0
ZNF350	59348	broad.mit.edu	37	19	52468457	52468457	+	Silent	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr19:52468457G>A	ENST00000243644.4	-	5	1476	c.1249C>T	c.(1249-1251)Ctg>Ttg	p.L417L	HCCAT3_ENST00000600253.1_RNA|HCCAT3_ENST00000595010.1_RNA	NM_021632.3	NP_067645.3	Q9GZX5	ZN350_HUMAN	zinc finger protein 350	417					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix|transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(7)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_neural(266;0.0505)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0179)		TGCTTAACCAGACACGACATA	0.468000													18	13					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190878646	190878646	+	Nonsense_Mutation	SNP	G	G	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr4:190878646G>T	ENST00000226798.4	+	6	748	c.526G>T	c.(526-528)Gaa>Taa	p.E176*	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	176					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus		p.E176*(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		AGGAGAAGAAGAAATGATCAA	0.373000													3	29					1	1	1	1	0
FAM47B	170062	broad.mit.edu	37	X	34962775	34962775	+	Missense_Mutation	SNP	G	G	C			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chrX:34962775G>C	ENST00000329357.5	+	1	1863	c.1827G>C	c.(1825-1827)aaG>aaC	p.K609N		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	609										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TCATTGAAAAGCTGTTTGCCA	0.438000													49	86					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073351	17073351	+	Silent	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr22:17073351C>T	ENST00000359963.3	-	1	349	c.90G>A	c.(88-90)gaG>gaA	p.E30E		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	30					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GCAGGTGGGGCTCCTCCTCTT	0.657000													14	22					0	0	1	0	0
FAM111A	63901	broad.mit.edu	37	11	58919526	58919526	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr11:58919526C>T	ENST00000528737.1	+	5	3203	c.385C>T	c.(385-387)Cgt>Tgt	p.R129C	FAM111A_ENST00000533703.1_Missense_Mutation_p.R129C|FAM111A_ENST00000531147.1_Missense_Mutation_p.R129C|FAM111A_ENST00000420244.1_Missense_Mutation_p.R129C|FAM111A_ENST00000361723.3_Missense_Mutation_p.R129C			Q96PZ2	F111A_HUMAN	family with sequence similarity 111, member A	129					proteolysis		serine-type endopeptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_epithelial(135;0.139)				AATGCTTGTGCGTGGCACAGA	0.443000													17	31					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57971059	57971059	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr11:57971059T>C	ENST00000302592.6	-	1	594	c.595A>G	c.(595-597)Aaa>Gaa	p.K199E		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	199					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				CAGGACAGTTTGAGCAGAGGG	0.413000													33	75					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47537946	47537946	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr4:47537946A>G	ENST00000273859.3	+	7	1180	c.911A>G	c.(910-912)aAc>aGc	p.N304S	ATP10D_ENST00000504445.1_Missense_Mutation_p.N304S	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	304					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.N304T(1)		NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						ATGCTGAACAACAGTGGGCCA	0.408000													11	37					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52668651	52668651	+	Silent	SNP	G	G	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr15:52668651G>A	ENST00000399231.3	-	19	2556	c.2313C>T	c.(2311-2313)atC>atT	p.I771I	MYO5A_ENST00000399233.2_Silent_p.I771I|MYO5A_ENST00000358212.6_Silent_p.I771I|MYO5A_ENST00000553916.1_Silent_p.I771I|MYO5A_ENST00000356338.6_Silent_p.I771I	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	771	IQ 1.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TCTGGATCCGGATGCAGGCAG	0.517000													12	32					0	0	1	0	0
STX16	8675	broad.mit.edu	37	20	57251288	57251288	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr20:57251288A>G	ENST00000371141.4	+	9	1643	c.919A>G	c.(919-921)Ata>Gta	p.I307V	STX16_ENST00000355957.5_Missense_Mutation_p.I290V|STX16_ENST00000358029.4_Missense_Mutation_p.I303V|STX16-NPEPL1_ENST00000530122.1_Intron|STX16_ENST00000359617.4_Missense_Mutation_p.I254V|STX16_ENST00000361770.5_Missense_Mutation_p.I290V|STX16_ENST00000361830.3_Missense_Mutation_p.I307V|STX16_ENST00000371132.4_Missense_Mutation_p.I286V	NM_001001433.2	NP_001001433.1	O14662	STX16_HUMAN	syntaxin 16	307					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			breast(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(1)	17	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			TGTGATTTTAATATTATTTGT	0.433000													17	42					0	0	1	0	0
SSU72	29101	broad.mit.edu	37	1	1509924	1509924	+	Frame_Shift_Del	DEL	G	G	-			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr1:1509924delG	ENST00000359060.4	-	1	40	c.14delC	c.(13-15)cgfs	p.P5fs	SSU72_ENST00000291386.3_Frame_Shift_Del_p.P5fs			Q9NP77	SSU72_HUMAN	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	5					mRNA processing	cytoplasm|nucleus	phosphoprotein phosphatase activity			large_intestine(2)|lung(5)	7	all_cancers(77;0.00125)|all_epithelial(69;0.000703)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.03e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;5.04e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.72e-23)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;0.000188)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|STAD - Stomach adenocarcinoma(132;0.00645)|BRCA - Breast invasive adenocarcinoma(365;0.00837)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		CACCCGCAGCGGGGACGACGG	0.701													2	4	---	---	---	---					
KDM1A	23028	broad.mit.edu	37	1	23356963	23356964	+	Splice_Site	INS	-	-	A			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr1:23356963_23356964insA	ENST00000400181.4	+	2	457_458	c.351_splice	c.e2-1	p.G118_splice	RP1-184J9.2_ENST00000427154.1_RNA|KDM1A_ENST00000542151.1_Splice_Site_p.G118_splice|KDM1A_ENST00000356634.3_Splice_Site_p.G118_splice	NM_001009999.2	NP_001009999.1	O60341	KDM1A_HUMAN	lysine (K)-specific demethylase 1A	118					blood coagulation|muscle cell development|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of protein binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin	androgen receptor binding|chromatin binding|enzyme binding|flavin adenine dinucleotide binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-K9 specific)|ligand-dependent nuclear receptor transcription coactivator activity|MyoD binding|oxidoreductase activity|p53 binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(2)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TCCATATAGGTAGAGTACAGAG	0.386													9	8	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708697	180708698	+	RNA	INS	-	-	A	rs1815381		TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr5:180708697_180708698insA	ENST00000412295.2	+	0	238																											ggggcggtaggcgggggctgga	0.718													2	4	---	---	---	---					
UHRF1	29128	broad.mit.edu	37	19	4960949	4960949	+	RNA	DEL	T	T	-	rs147409935		TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr19:4960949delT	ENST00000592666.1	+	0	3092							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		TTTGTCTTCCttttttttttt	0.343													4	3	---	---	---	---					
CIC	23152	broad.mit.edu	37	19	42798120	42798121	+	Frame_Shift_Ins	INS	-	-	T			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr19:42798120_42798121insT	ENST00000572681.2	+	18	6860_6861	c.6792_6793insT	c.(6790-6795)cgttgcfs	p.C2265fs	CIC_ENST00000160740.3_Frame_Shift_Ins_p.C1357fs|CIC_ENST00000575354.2_Frame_Shift_Ins_p.C1359fs			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	1359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				TCGAAGAGCGCTTTGCTGAGTT	0.663			"""Mis, F, S"""		oligodendroglioma								34	22	---	---	---	---					
ASXL1	171023	broad.mit.edu	37	20	31022401	31022402	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-TM-A84O-01A-11D-A36O-08	TCGA-TM-A84O-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	043d7b5e-441a-41a1-a59a-4057e486b5e1	b593c768-61c5-483e-a22d-94af00406293	g.chr20:31022401_31022402delGT	ENST00000375687.4	+	13	2310_2311	c.1886_1887delGT	c.(1885-1887)gfs	p.G629fs	ASXL1_ENST00000306058.5_Frame_Shift_Del_p.G624fs	NM_015338.5	NP_056153.2	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 (Drosophila)	629					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(655)|kidney(5)|large_intestine(18)|liver(1)|lung(27)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	722						GGGGCGAGAGGTCACCACTGCC	0.698			"""F, N, Mis"""		"""MDS, CMML"""								10	11	---	---	---	---