Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ITGB6	3694	broad.mit.edu	37	2	161052119	161052119	+	Silent	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr2:161052119C>T	ENST00000283249.2	-	4	591	c.354G>A	c.(352-354)gcG>gcA	p.A118A	ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000428609.2_Silent_p.A76A|ITGB6_ENST00000409872.1_Silent_p.A118A|ITGB6_ENST00000409967.2_Silent_p.A118A			P18564	ITB6_HUMAN	integrin, beta 6	118					cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						GCAGAGTCTGCGCACCACCTG	0.532000													3	48					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55566774	55566774	+	Silent	SNP	T	T	C			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr2:55566774T>C	ENST00000436346.1	-	13	2185	c.1344A>G	c.(1342-1344)aaA>aaG	p.K448K	AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000594078.1_RNA|CCDC88A_ENST00000413716.2_Silent_p.K448K|CCDC88A_ENST00000336838.6_Silent_p.K448K|CCDC88A_ENST00000263630.8_Silent_p.K448K|AC012358.8_ENST00000599352.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	448					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						GGCCCAGGGATTTCTGGGGTG	0.338000													4	50					0	0	1	0	0
MGAT4B	11282	broad.mit.edu	37	5	179228989	179228989	+	Silent	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr5:179228989C>T	ENST00000337755.5	-	1	1009	c.123G>A	c.(121-123)acG>acA	p.T41T	MGAT4B_ENST00000292591.7_Intron|MGAT4B_ENST00000521305.1_Intron	NM_054013.3	NP_463459.1	Q9UQ53	MGT4B_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	0					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	13	all_cancers(89;0.000201)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0525)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTAGGCAAGCCGTCACGAGGG	0.627000											OREG0017110	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	69					0	0	1	0	0
CTSV	1515	broad.mit.edu	37	9	99800203	99800203	+	Silent	SNP	G	G	C			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr9:99800203G>C	ENST00000259470.5	-	2	372	c.123C>G	c.(121-123)ggC>ggG	p.G41G	CTSV_ENST00000479932.1_5'UTR|CTSV_ENST00000538255.1_Silent_p.G41G	NM_001333.3	NP_001324.2			cathepsin V																		TACCAACCGCGCCATATAATC	0.478000													5	69					0	0	1	0	0
KCNIP1	0	broad.mit.edu	37	5	170160874	170160874	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr5:170160874T>C	ENST00000328939.4	+	7	1112	c.575T>C	c.(574-576)tTa>tCa	p.L192S	KCNIP1_ENST00000411494.1_Missense_Mutation_p.L203S|KCNIP1_ENST00000520740.1_Missense_Mutation_p.L164S|KCNIP1_ENST00000377360.4_Missense_Mutation_p.L201S|KCNIP1_ENST00000390656.4_Missense_Mutation_p.L192S|KCNIP1_ENST00000434108.1_Missense_Mutation_p.L217S	NM_001034837.1|NM_014592.2	NP_001030009.1|NP_055407.1	Q9NZI2	KCIP1_HUMAN	Kv channel interacting protein 1	203	EF-hand 4.				detection of calcium ion|signal transduction|synaptic transmission	plasma membrane	potassium channel activity|voltage-gated ion channel activity			autonomic_ganglia(1)|large_intestine(7)|lung(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	18	Renal(175;0.000159)|Lung NSC(126;0.0191)|all_lung(126;0.0297)	Medulloblastoma(196;0.0109)|all_neural(177;0.0177)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATCGTAACTTTAGATGAATTT	0.428000													4	45					0	0	1	0	0
FKBP8	23770	broad.mit.edu	37	19	18652528	18652528	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr19:18652528C>T	ENST00000597960.2	-	2	373	c.253G>A	c.(253-255)Gcc>Acc	p.A85T	FKBP8_ENST00000596558.1_Missense_Mutation_p.A85T|FKBP8_ENST00000453489.2_Missense_Mutation_p.A114T|FKBP8_ENST00000544835.2_Missense_Mutation_p.A85T|FKBP8_ENST00000222308.3_Missense_Mutation_p.A85T			Q14318	FKBP8_HUMAN	FK506 binding protein 8, 38kDa	85	Glu-rich.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	15						GGGGCTGGGGCGGGCTCGGGC	0.692000													15	25					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	SIRPB1_ENST00000381603.3_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A|SIRPB1_ENST00000381605.4_Intron|RP4-576H24.4_ENST00000564763.1_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													3	27					0	0	1	0	0
MYO19	80179	broad.mit.edu	37	17	34862971	34862971	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr17:34862971C>T	ENST00000431794.3	-	17	1997	c.1475G>A	c.(1474-1476)cGc>cAc	p.R492H	MYO19_ENST00000268852.9_Intron	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	492	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TCGATTGAGGCGGCATTCCTG	0.637000													7	43					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132262879	132262879	+	Silent	SNP	A	A	G			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr5:132262879A>G	ENST00000265343.5	-	5	1363	c.984T>C	c.(982-984)ccT>ccC	p.P328P	AFF4_ENST00000491831.1_5'UTR|AFF4_ENST00000378595.3_Silent_p.P328P	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	328	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTAGAGGGGGAGGCCATGAAT	0.333000													3	48					0	0	1	0	0
GRAP2	9402	broad.mit.edu	37	22	40343126	40343126	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr22:40343126A>G	ENST00000344138.4	+	2	279	c.16A>G	c.(16-18)Aag>Gag	p.K6E	GRAP2_ENST00000544756.1_5'UTR|GRAP2_ENST00000543252.1_Missense_Mutation_p.K6E|GRAP2_ENST00000478445.1_Intron|GRAP2_ENST00000540310.1_Intron|GRAP2_ENST00000399090.2_Intron|GRAP2_ENST00000407075.3_Missense_Mutation_p.K6E	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	6	SH3 1.				cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						AGCTGTTGCCAAGTTTGATTT	0.527000													5	73					0	0	1	0	0
PPIP5K1	9677	broad.mit.edu	37	15	43827518	43827518	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr15:43827518C>T	ENST00000420765.1	-	31	3838	c.3656G>A	c.(3655-3657)gGg>gAg	p.G1219E	PPIP5K1_ENST00000334933.4_Missense_Mutation_p.G1194E|PPIP5K1_ENST00000360301.4_Missense_Mutation_p.G1194E|PPIP5K1_ENST00000396923.3_Missense_Mutation_p.G1219E|PPIP5K1_ENST00000381879.4_Missense_Mutation_p.G1195E|PPIP5K1_ENST00000381885.1_Missense_Mutation_p.G1215E|PPIP5K1_ENST00000360135.4_Missense_Mutation_p.G1192E|PPIP5K1_ENST00000348806.6_Missense_Mutation_p.G1192E	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1219					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						TGCTCCACTCCCAGGGGTCTC	0.527000													32	58					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								30	51					0	0	1	0	0
SLC45A2	51151	broad.mit.edu	37	5	33951714	33951714	+	Silent	SNP	G	G	A			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr5:33951714G>A	ENST00000382102.3	-	5	1158	c.1101C>T	c.(1099-1101)gtC>gtT	p.V367V	SLC45A2_ENST00000342059.3_Silent_p.V308V|SLC45A2_ENST00000296589.4_Silent_p.V367V|SLC45A2_ENST00000509381.1_3'UTR|SLC45A2_ENST00000345083.5_Silent_p.V259V	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	367					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						ATCCAACCTCGACTCCTCTTT	0.453000													16	103					0	0	1	0	0
TLK1	9874	broad.mit.edu	37	2	171863512	171863512	+	Missense_Mutation	SNP	C	C	G			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr2:171863512C>G	ENST00000442919.2	-	15	1949	c.1334G>C	c.(1333-1335)tGg>tCg	p.W445S	TLK1_ENST00000360843.3_Missense_Mutation_p.W514S|TLK1_ENST00000521943.1_Missense_Mutation_p.W445S|TLK1_ENST00000431350.2_Missense_Mutation_p.W493S|TLK1_ENST00000434911.2_Missense_Mutation_p.W397S	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	493					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						CTCATCTCTCCAGCTTTTATT	0.294000													16	55					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27101006	27101006	+	Nonsense_Mutation	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr1:27101006C>T	ENST00000324856.7	+	18	4659	c.4288C>T	c.(4288-4290)Cag>Tag	p.Q1430*	ARID1A_ENST00000457599.2_Intron|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.Q1047*|ARID1A_ENST00000540690.1_Intron	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1430					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGTATACAACCAGTATGGCAA	0.627000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								9	39					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952072	178952072	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr3:178952072A>G	ENST00000263967.3	+	21	3284	c.3127A>G	c.(3127-3129)Atg>Gtg	p.M1043V		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1043	PI3K/PI4K.		M -> I (in cancer; shows an increase in lipid kinase activity).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.M1043V(22)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CATGAAACAAATGAATGATGC	0.368000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			6	49					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57867389	57867389	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr12:57867389C>T	ENST00000393797.2	-	20	2483	c.2291G>A	c.(2290-2292)tGc>tAc	p.C764Y	ARHGAP9_ENST00000430041.2_Missense_Mutation_p.C490Y|ARHGAP9_ENST00000424809.2_Intron|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.C674Y|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.C693Y|ARHGAP9_ENST00000550288.1_3'UTR			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	693					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			TCCTGACCTGCATAAATGCTC	0.517000													11	44					0	0	1	0	0
ZNF18	7566	broad.mit.edu	37	17	11881794	11881794	+	Missense_Mutation	SNP	G	G	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr17:11881794G>T	ENST00000322748.3	-	9	1734	c.1130C>A	c.(1129-1131)cCt>cAt	p.P377H	ZNF18_ENST00000580306.1_Missense_Mutation_p.P377H|ZNF18_ENST00000580613.1_Intron|ZNF18_ENST00000454073.3_Missense_Mutation_p.P376H	NM_144680.2	NP_653281.2	P17022	ZNF18_HUMAN	zinc finger protein 18	377					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)	14				Colorectal(4;3.33e-05)|COAD - Colon adenocarcinoma(4;0.000494)|READ - Rectum adenocarcinoma(10;0.233)		TCCTGAATGAGGATTAGGCAA	0.532000													32	60					1.7881e-09	1.7881e-09	1	1	0
ZNF844	284391	broad.mit.edu	37	19	12187394	12187394	+	Missense_Mutation	SNP	T	T	C			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr19:12187394T>C	ENST00000439326.3	+	4	1634	c.1459T>C	c.(1459-1461)Ttt>Ctt	p.F487L	ZNF844_ENST00000441304.2_3'UTR	NM_001136501.1	NP_001129973.1	Q08AG5	ZN844_HUMAN	zinc finger protein 844	487					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F487L(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(1)|prostate(1)	10						GCCTTCATTTTTTCCACTTCC	0.448000													3	72					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4016307	4016307	+	Silent	SNP	G	G	A	rs146365616		TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr16:4016307G>A	ENST00000294016.3	-	11	4069	c.3531C>T	c.(3529-3531)atC>atT	p.I1177I		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1177	Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TGGTGGTGCCGATGACCCCGG	0.607000													12	86					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43944836	43944836	+	Missense_Mutation	SNP	C	C	T			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr12:43944836C>T	ENST00000389420.3	-	2	328	c.329G>A	c.(328-330)gGa>gAa	p.G110E	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G110E	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	110						proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTCCGGGGTTCCCAAGTGCAC	0.657000													4	21					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36641143	36641143	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr20:36641143G>A	ENST00000373448.2	-	3	1314	c.1076C>T	c.(1075-1077)gCa>gTa	p.A359V	TTI1_ENST00000487362.1_Intron|TTI1_ENST00000449821.1_Missense_Mutation_p.A359V|TTI1_ENST00000373447.3_Missense_Mutation_p.A359V	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	359							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						TTTTTGATCTGCAAAATGTCT	0.478000													4	142					0	0	1	0	0
ITGB3	3690	broad.mit.edu	37	17	45377877	45377877	+	Missense_Mutation	SNP	A	A	G			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr17:45377877A>G	ENST00000560629.1	+	12	1912	c.1912A>G	c.(1912-1914)Agc>Ggc	p.S638G	ITGB3_ENST00000559488.1_Silent_p.G649G|ITGB3_ENST00000435993.2_Silent_p.G602G			P05106	ITB3_HUMAN	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0					activation of protein kinase activity|angiogenesis involved in wound healing|axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|platelet activation|platelet degranulation|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of bone resorption|smooth muscle cell migration|tube development	alphav-beta3 integrin-vitronectin complex|integrin complex|platelet alpha granule membrane	cell adhesion molecule binding|identical protein binding|platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	39					Abciximab(DB00054)|Tirofiban(DB00775)	TTGACCGGGGAGCCCTACATG	0.483000													3	39					0	0	1	0	0
ZNF577	84765	broad.mit.edu	37	19	52375975	52375975	+	Missense_Mutation	SNP	G	G	A			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr19:52375975G>A	ENST00000420592.1	-	6	2424	c.1091C>T	c.(1090-1092)cCg>cTg	p.P364L	ZNF577_ENST00000412216.1_Intron|ZNF577_ENST00000451628.2_Missense_Mutation_p.P364L|ZNF577_ENST00000485702.1_Intron|ZNF577_ENST00000301399.5_Missense_Mutation_p.P423L			Q9BSK1	ZN577_HUMAN	zinc finger protein 577	423					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.P416Q(1)		breast(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TAACAATGGCGGGGTTCCTGA	0.428000													5	53					0	0	1	0	0
AARS	16	broad.mit.edu	37	16	70295033	70295033	+	Missense_Mutation	SNP	G	G	C			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr16:70295033G>C	ENST00000261772.8	-	13	1842	c.1699C>G	c.(1699-1701)Cag>Gag	p.Q567E	AARS_ENST00000564359.1_5'UTR	NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	567					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	CCTCGGACCTGAGCATTCTTC	0.398000													19	39					0	0	1	0	0
NRDE2	55051	broad.mit.edu	37	14	90784399	90784399	+	Silent	SNP	T	T	C			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr14:90784399T>C	ENST00000354366.3	-	2	355	c.123A>G	c.(121-123)caA>caG	p.Q41Q	NRDE2_ENST00000357904.3_Intron|NRDE2_ENST00000557106.1_5'UTR	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		CTTCAGTTTGTTGGCTCAGGG	0.428000													47	94					0	0	1	0	0
TRBV29-1	0	broad.mit.edu	37	7	142448200	142448207	+	RNA	DEL	GGTGGAAA	GGTGGAAA	-	rs149832120	by1000genomes	TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chr7:142448200_142448207delGGTGGAAA	ENST00000422143.2	+	0	101																											GTTAACACTGGGTGGAAAGGTGGAAAGA	0.457													4	3	---	---	---	---					
RP11-308D16.4	0	broad.mit.edu	37	X	136030245	136030245	+	RNA	DEL	T	T	-			TCGA-TM-A84S-01A-11D-A36O-08	TCGA-TM-A84S-10A-01D-A367-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	04900639-99a7-4c20-944b-77fab59a174a	59753c32-0a08-46aa-94cc-cc88d0455862	g.chrX:136030245delT	ENST00000424306.1	+	0	2052																											GAGAACCTGCTTTTTTTTTTT	0.438													3	5	---	---	---	---