Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DGAT2L6	347516	broad.mit.edu	37	X	69424320	69424320	+	Silent	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:69424320C>T	ENST00000333026.3	+	6	913	c.813C>T	c.(811-813)cgC>cgT	p.R271R		NM_198512.1	NP_940914.1	Q6ZPD8	DG2L6_HUMAN	diacylglycerol O-acyltransferase 2-like 6	271					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(1)	12						GCTTCACTCGCGGATCCTGGG	0.502000													65	86					0	0	1	0	0
FBXO11	80204	broad.mit.edu	37	2	48040489	48040489	+	Missense_Mutation	SNP	A	A	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:48040489A>T	ENST00000403359.3	-	18	2183	c.2111T>A	c.(2110-2112)aTa>aAa	p.I704K	FBXO11_ENST00000434523.2_Missense_Mutation_p.I128K|FBXO11_ENST00000316377.4_Missense_Mutation_p.I620K|FBXO11_ENST00000402508.1_Missense_Mutation_p.I620K	NM_001190274.1	NP_001177203.1	Q86XK2	FBX11_HUMAN	F-box protein 11	704					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding	p.0?(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATTGTCAAATATTTCATTGTC	0.294000			"""Mis, F, D"""		DLBCL								73	140					0	0	1	0	0
PRKCA	5578	broad.mit.edu	37	17	64684479	64684479	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr17:64684479G>A	ENST00000413366.3	+	7	772	c.746G>A	c.(745-747)cGa>cAa	p.R249Q		NM_002737.2	NP_002728.1	P17252	KPCA_HUMAN	protein kinase C, alpha	249	C2.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GACTGGGATCGAACAACAAGG	0.463000													61	83					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274170	39274170	+	Missense_Mutation	SNP	G	G	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr17:39274170G>T	ENST00000391413.2	-	1	436	c.398C>A	c.(397-399)aCc>aAc	p.T133N		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	133	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament				endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			gtggcagcaggtgggctggca	0.672000													4	82					0.0293803	0.0298061	1	1	0
MYH7	4625	broad.mit.edu	37	14	23889440	23889440	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr14:23889440G>A	ENST00000355349.3	-	27	3502	c.3340C>T	c.(3340-3342)Cgc>Tgc	p.R1114C		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1114					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		tcctcGATGCGTGCCTGGTCA	0.637000													3	49					0	0	1	0	0
GALNT3	2591	broad.mit.edu	37	2	166615936	166615936	+	Missense_Mutation	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:166615936C>T	ENST00000392701.3	-	5	1758	c.983G>A	c.(982-984)cGt>cAt	p.R328H	GALNT3_ENST00000409882.1_Missense_Mutation_p.R66H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	328					protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						AAAATTTCCACGGTTATGGTT	0.413000													46	59					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175603980	175603980	+	Nonsense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr4:175603980G>A	ENST00000274093.3	-	6	1187	c.685C>T	c.(685-687)Cga>Tga	p.R229*	GLRA3_ENST00000340217.5_Nonsense_Mutation_p.R229*	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	229					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	GTGCAGTATCGTAAATCTTTT	0.368000													56	62					0	0	1	0	0
TUBBP5	0	broad.mit.edu	37	9	141070071	141070071	+	RNA	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr9:141070071G>A	ENST00000503395.1	+	0	1151																											TACGTGCCCCGCGCTGTGCTC	0.706000													34	61					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23909715	23909715	+	Missense_Mutation	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr13:23909715C>T	ENST00000382298.3	-	10	8888	c.8300G>A	c.(8299-8301)gGc>gAc	p.G2767D	SACS_ENST00000382292.3_Missense_Mutation_p.G2767D|SACS_ENST00000402364.1_Missense_Mutation_p.G2017D	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2767					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTGATTTTGCCCTTTACTGA	0.348000													4	206					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47369674	47369674	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr18:47369674G>A	ENST00000285039.7	-	34	4847	c.4548C>T	c.(4546-4548)aaC>aaT	p.N1516N	MYO5B_ENST00000324581.6_Silent_p.N631N|SCARNA17_ENST00000589499.1_RNA|MYO5B_ENST00000592688.1_Silent_p.N86N	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1516					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TGAGATCGTCGTTGGTGTAGT	0.567000													64	72					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6644395	6644395	+	Missense_Mutation	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr11:6644395T>C	ENST00000299441.3	-	21	8923	c.8512A>G	c.(8512-8514)Aca>Gca	p.T2838A		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	2838	Cadherin 27.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTCATCTGTGGCCTGCACG	0.572000													13	18					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109694736	109694736	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:109694736G>A	ENST00000465301.2	+	3	1137	c.891G>A	c.(889-891)ccG>ccA	p.P297P	RGAG1_ENST00000540313.1_Silent_p.P297P	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	297										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						TACCTACCCCGCTCATGTCAG	0.483000													5	431					0	0	1	0	0
ARHGEF18	23370	broad.mit.edu	37	19	7528785	7528785	+	Missense_Mutation	SNP	C	C	T	rs149572002		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:7528785C>T	ENST00000359920.6	+	12	2406	c.2153C>T	c.(2152-2154)cCg>cTg	p.P718L	ARHGEF18_ENST00000319670.9_Missense_Mutation_p.P560L|CTD-2207O23.3_ENST00000593531.1_Missense_Mutation_p.R676C	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	718					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				TCCACAGGCCCGCCCAGGAGG	0.682000													10	12					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124418865	124418865	+	Nonsense_Mutation	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr3:124418865C>T	ENST00000360013.3	+	56	8108	c.7981C>T	c.(7981-7983)Cga>Tga	p.R2661*	KALRN_ENST00000291478.4_Nonsense_Mutation_p.R964*|KALRN_ENST00000428018.2_Nonsense_Mutation_p.R932*	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2660					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						GGAGTTTGTGCGACTTCCAGA	0.597000													4	244					0	0	1	0	0
ZNF845	91664	broad.mit.edu	37	19	53856761	53856761	+	Missense_Mutation	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:53856761T>C	ENST00000458035.1	+	4	2950	c.2833T>C	c.(2833-2835)Tgt>Cgt	p.C945R	ZNF845_ENST00000595091.1_Missense_Mutation_p.C945R	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	945					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C945R(1)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						ACCTTACAAGTGTAATGAATG	0.348000													4	22					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285750	223285750	+	Silent	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr1:223285750C>T	ENST00000540964.1	-	4	1085	c.624G>A	c.(622-624)ttG>ttA	p.L208L	TLR5_ENST00000342210.6_Silent_p.L208L			O60602	TLR5_HUMAN	toll-like receptor 5	208					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		CTCTGCTATACAAGCTATTAG	0.443000													66	93					0	0	1	0	0
NINL	22981	broad.mit.edu	37	20	25507065	25507065	+	Silent	SNP	G	G	T	rs142387243		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr20:25507065G>T	ENST00000278886.6	-	2	232	c.159C>A	c.(157-159)ctC>ctA	p.L53L	NINL_ENST00000422516.1_Silent_p.L53L	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	53	EF-hand 2.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GGTCGTTTCCGAGAAGCGTCT	0.542000													108	165					7.5252e-50	8.10406e-50	1	1	0
MIR1185-2	0	broad.mit.edu	37	14	101510545	101510545	+	RNA	SNP	A	A	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr14:101510545A>T	ENST00000408687.1	+	0	11					NR_031571.1																						TTTGGTACTTAAAGAGAGGAT	0.522000													5	140					0	0	1	0	0
PCDHGA3	0	broad.mit.edu	37	5	140723837	140723837	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr5:140723837G>A	ENST00000253812.6	+	1	237	c.237G>A	c.(235-237)ccG>ccA	p.P79P	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTGAATCCGCAAAGCGGCA	0.587000											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	220					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1325396	1325396	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:1325396G>A	ENST00000381567.3	-	3	278	c.279C>T	c.(277-279)gaC>gaT	p.D93D	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Silent_p.D93D	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	93						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AATAGAGAATGTCGTCTCGCT	0.517000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								25	189					0	0	1	0	0
UNKL	64718	broad.mit.edu	37	16	1451675	1451675	+	Silent	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr16:1451675C>T	ENST00000389221.4	-	4	491	c.492G>A	c.(490-492)caG>caA	p.Q164Q	UNKL_ENST00000397462.1_Silent_p.Q251Q|UNKL_ENST00000508903.2_Silent_p.Q164Q|UNKL_ENST00000301712.5_Silent_p.Q164Q|UNKL_ENST00000503648.1_5'UTR	NM_001193388.1	NP_001180317.1	Q9H9P5	UNKL_HUMAN	unkempt family zinc finger-like	164						cytoplasm|nucleus	ligase activity|nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(1)|lung(1)	4		Hepatocellular(780;0.0893)				GCTGGCCGTTCTGCAAGGCTT	0.647000													3	61					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107340552	107340552	+	Missense_Mutation	SNP	A	A	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr7:107340552A>C	ENST00000265715.3	+	15	1863	c.1639A>C	c.(1639-1641)Att>Ctt	p.I547L	SLC26A4_ENST00000544569.1_Missense_Mutation_p.I134L|SLC26A4_ENST00000541474.1_Missense_Mutation_p.I108L|SLC26A4_ENST00000480841.1_3'UTR|SLC26A4_ENST00000543100.1_Missense_Mutation_p.I116L	NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	547	STAS.				regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						AGGAGTGAAGATTCTTAGATT	0.318000									Pendred syndrome				55	121					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112058796	112058796	+	Silent	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:112058796C>T	ENST00000371959.3	-	2	1181	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	AMOT_ENST00000371962.1_Silent_p.Q162Q|AMOT_ENST00000304758.1_5'UTR|AMOT_ENST00000371958.1_Silent_p.Q162Q|AMOT_ENST00000524145.1_Silent_p.Q394Q	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	394					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q394Q(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						gctgctgctgctgttgttggt	0.582000													4	99					0	0	1	0	0
RNASE13	440163	broad.mit.edu	37	14	21502144	21502144	+	Missense_Mutation	SNP	G	G	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr14:21502144G>C	ENST00000382951.3	-	2	441	c.304C>G	c.(304-306)Ctc>Gtc	p.L102V	NDRG2_ENST00000403829.3_Intron	NM_001012264.3	NP_001012264.1	Q5GAN3	RNS13_HUMAN	ribonuclease, RNase A family, 13 (non-active)	102						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			cervix(1)|endometrium(1)|lung(5)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	12	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.019)		TCCTGGGTGAGTGTGCAGTAT	0.498000													94	129					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412664	139412664	+	Missense_Mutation	SNP	C	C	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr9:139412664C>A	ENST00000277541.6	-	7	1255	c.1180G>T	c.(1180-1182)Ggc>Tgc	p.G394C		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	394	EGF-like 10.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ATGGCCTTGCCATTGACAGGG	0.667000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			9	14					0.00448238	0.00461422	1	1	0
CX3CL1	6376	broad.mit.edu	37	16	57416150	57416150	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr16:57416150G>A	ENST00000565912.1	+	2	2992	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K	CX3CL1_ENST00000006053.6_Missense_Mutation_p.E134K|CX3CL1_ENST00000564948.1_3'UTR|CX3CL1_ENST00000563383.1_Missense_Mutation_p.E140K			P78423	X3CL1_HUMAN	chemokine (C-X3-C motif) ligand 1	134	Chemokine.				cell adhesion|cytokine-mediated signaling pathway|defense response|immune response|leukocyte adhesive activation|positive regulation of calcium-independent cell-cell adhesion|positive regulation of inflammatory response	cell surface|extracellular space|integral to membrane|plasma membrane	chemokine activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)	5						AGCCACAGGCGAAAGCAGTAG	0.667000													4	114					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66459037	66459037	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr5:66459037G>A	ENST00000404260.3	+	29	4347	c.4039G>A	c.(4039-4041)Ggg>Agg	p.G1347R	MAST4_ENST00000403625.2_Missense_Mutation_p.G1344R|MAST4_ENST00000405643.1_Missense_Mutation_p.G1165R|MAST4_ENST00000403666.1_Missense_Mutation_p.G1155R|MAST4_ENST00000261569.7_Missense_Mutation_p.G1150R			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	1347						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGCAGGGTCCGGGCACATCCG	0.612000													28	333					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152425801	152425801	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:152425801G>A	ENST00000397345.3	-	110	17718	c.17516C>T	c.(17515-17517)gCc>gTc	p.A5839V	NEB_ENST00000172853.10_Missense_Mutation_p.A4138V|NEB_ENST00000427231.2_Missense_Mutation_p.A5839V|NEB_ENST00000409198.1_Missense_Mutation_p.A4138V|NEB_ENST00000603639.1_Missense_Mutation_p.A5839V|NEB_ENST00000604864.1_Missense_Mutation_p.A5839V	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5858					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GATGTCCGCGGCATGTTTGGC	0.433000													44	53					0	0	1	0	0
WNK1	65125	broad.mit.edu	37	12	936450	936450	+	Missense_Mutation	SNP	G	G	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr12:936450G>T	ENST00000447667.2	+	3	1685	c.1175G>T	c.(1174-1176)gGa>gTa	p.G392V	WNK1_ENST00000537687.1_Intron|WNK1_ENST00000535572.1_Intron|WNK1_ENST00000530271.2_Intron|WNK1_ENST00000315939.6_Intron			Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	0	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GTGTACCTTGGAGCCTGACTG	0.453000													10	122					0.000442599	0.000462417	1	1	0
B3GALNT2	148789	broad.mit.edu	37	1	235617570	235617570	+	Silent	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr1:235617570C>T	ENST00000366600.3	-	10	1437	c.1209G>A	c.(1207-1209)ccG>ccA	p.P403P		NM_152490.2	NP_689703.1	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	403					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			AAGCGGGGCTCGGGTACTCCA	0.507000													54	124					0	0	1	0	0
PARP3	10039	broad.mit.edu	37	3	51979052	51979052	+	Nonsense_Mutation	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr3:51979052C>T	ENST00000417220.2	+	7	1161	c.673C>T	c.(673-675)Cag>Tag	p.Q225*	PARP3_ENST00000431474.1_Nonsense_Mutation_p.Q225*|PARP3_ENST00000398755.3_Nonsense_Mutation_p.Q232*			Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	225	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GAGCAAGCAACAGATTGCACG	0.627000													48	76					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103317573	103317573	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:103317573G>A	ENST00000233969.2	+	8	1773	c.1631G>A	c.(1630-1632)cGg>cAg	p.R544Q	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	544						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CTTTTGATTCGGGAAAACCAA	0.318000													98	127					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113112	209113112	+	Missense_Mutation	SNP	C	C	T	rs121913500		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:209113112C>T	ENST00000415913.1	-	4	776	c.395G>A	c.(394-396)cGt>cAt	p.R132H	IDH1_ENST00000345146.2_Missense_Mutation_p.R132H|IDH1_ENST00000446179.1_Missense_Mutation_p.R132H			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132H(2774)|p.R132L(59)|p.R132V(1)|p.G131_R132>VL(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		ATAAGCATGACGACCTATGAT	0.393000			Mis		gliobastoma								63	101					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77667377	77667377	+	Silent	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr13:77667377C>T	ENST00000407578.2	-	59	10556	c.10290G>A	c.(10288-10290)ccG>ccA	p.P3430P	MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000357337.6_Silent_p.P3392P|MYCBP2_ENST00000544440.2_Silent_p.P3392P	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CTGATATATACGGGGCAGGTA	0.393000													116	143					0	0	1	0	0
ZHX3	23051	broad.mit.edu	37	20	39832611	39832611	+	Missense_Mutation	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr20:39832611T>C	ENST00000309060.3	-	4	1361	c.946A>G	c.(946-948)Aac>Gac	p.N316D	ZHX3_ENST00000540170.1_Missense_Mutation_p.N316D|ZHX3_ENST00000560361.1_Missense_Mutation_p.N316D|ZHX3_ENST00000559234.1_Missense_Mutation_p.N316D|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000544979.2_Missense_Mutation_p.N316D|ZHX3_ENST00000432768.2_Missense_Mutation_p.N316D			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	316	Required for homodimerization and interaction with NFYA.|Required for repressor activity.				negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				AGGAAGCTGTTAGAGTCCATG	0.537000													16	122					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158549195	158549195	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr1:158549195G>A	ENST00000368150.1	-	1	494	c.495C>T	c.(493-495)tgC>tgT	p.C165C		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					AGCCTGCAGTGCAAGCAGAGG	0.468000													9	63					0	0	1	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19713826	19713826	+	Missense_Mutation	SNP	C	C	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:19713826C>A	ENST00000397821.3	-	5	714	c.424G>T	c.(424-426)Ggg>Tgg	p.G142W	SH3KBP1_ENST00000379697.3_Missense_Mutation_p.G142W|SH3KBP1_ENST00000379698.4_Missense_Mutation_p.G105W	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	142	SH3 2.				apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						CCAGTCTTCCCGTTGAGAACA	0.473000													13	224					0.000219431	0.00023273	1	1	0
RP11-48B14.2	0	broad.mit.edu	37	17	3593419	3593419	+	Missense_Mutation	SNP	C	C	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr17:3593419C>A	ENST00000550383.1	-	6	747	c.559G>T	c.(559-561)Gac>Tac	p.D187Y	P2RX5_ENST00000345901.3_Missense_Mutation_p.D163Y|P2RX5_ENST00000552276.1_Missense_Mutation_p.D187Y|P2RX5_ENST00000225328.5_Missense_Mutation_p.D187Y|P2RX5_ENST00000552050.1_Missense_Mutation_p.D127Y|P2RX5_ENST00000551178.1_Missense_Mutation_p.D163Y|P2RX5_ENST00000550772.1_5'UTR|P2RX5_ENST00000547178.1_Missense_Mutation_p.D187Y|P2RX5_ENST00000435558.1_Missense_Mutation_p.D187Y																							ATGGTGAAGTCTTCGGCCTCC	0.587000													5	497					0.217242	0.217242	1	1	0
ZSWIM4	65249	broad.mit.edu	37	19	13941471	13941471	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:13941471G>A	ENST00000254323.2	+	13	2766	c.2577G>A	c.(2575-2577)cgG>cgA	p.R859R	ZSWIM4_ENST00000440752.2_Silent_p.R693R	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	859							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CCCTGGGCCGGCACGAGCTCT	0.657000													5	370					0	0	1	0	0
C3P1	0	broad.mit.edu	37	19	10158049	10158049	+	RNA	SNP	A	A	G			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:10158049A>G	ENST00000495140.1	+	0	1257																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						TTCTTTGTGGACCTTAAGTTG	0.532000													49	242					0	0	1	0	0
OR51G2	81282	broad.mit.edu	37	11	4936857	4936857	+	Missense_Mutation	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr11:4936857C>T	ENST00000322013.3	-	1	65	c.37G>A	c.(37-39)Gtt>Att	p.V13I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTAGCAGAAACGCTGCTGCTG	0.557000													49	60					0	0	1	0	0
ZNF558	148156	broad.mit.edu	37	19	8923829	8923829	+	Missense_Mutation	SNP	C	C	G			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:8923829C>G	ENST00000601372.1	-	8	1028	c.317G>C	c.(316-318)aGa>aCa	p.R106T	ZNF558_ENST00000444186.2_Missense_Mutation_p.R35T|ZNF558_ENST00000301475.1_Missense_Mutation_p.R106T			Q96NG5	ZN558_HUMAN	zinc finger protein 558	106	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						TAGAATTCCTCTTTCCTCTGT	0.463000													11	8					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111694039	111694039	+	Missense_Mutation	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr6:111694039T>C	ENST00000435970.1	-	15	6101	c.5285A>G	c.(5284-5286)tAt>tGt	p.Y1762C	REV3L_ENST00000358835.3_Missense_Mutation_p.Y1840C|REV3L_ENST00000368802.3_Missense_Mutation_p.Y1840C|REV3L_ENST00000368805.1_Missense_Mutation_p.Y1840C			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1840					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TCTTGAAACATACAGTTCTAA	0.433000								DNA polymerases (catalytic subunits)					4	347					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	131046325	131046325	+	Missense_Mutation	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr5:131046325C>T	ENST00000307954.8	-	6	545	c.517G>A	c.(517-519)Gca>Aca	p.A173T	FNIP1_ENST00000511848.1_Missense_Mutation_p.A218T|FNIP1_ENST00000307968.7_Intron|FNIP1_ENST00000510461.1_Missense_Mutation_p.A218T|FNIP1_ENST00000514667.1_Intron					folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TCAGAGAATGCCCGCCTGGGG	0.522000													3	49					0	0	1	0	0
HELLS	3070	broad.mit.edu	37	10	96334429	96334429	+	Missense_Mutation	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr10:96334429T>C	ENST00000348459.5	+	9	929	c.824T>C	c.(823-825)cTt>cCt	p.L275P	HELLS_ENST00000394045.1_Missense_Mutation_p.L275P|HELLS_ENST00000394044.1_Missense_Mutation_p.L275P|HELLS_ENST00000371332.4_Missense_Mutation_p.L275P|HELLS_ENST00000394036.1_3'UTR|HELLS_ENST00000239026.6_3'UTR	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	275	Helicase ATP-binding.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GGACCTTTTCTTGTCTGTGGC	0.373000													65	240					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102292765	102292765	+	RNA	SNP	C	C	T			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr15:102292765C>T	ENST00000561463.1	+	0	811																											GGCACAGCGGCGCGACGAGAT	0.602000													5	80					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113857553	113857553	+	Missense_Mutation	SNP	A	A	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr11:113857553A>C	ENST00000504030.2	+	8	1368	c.923A>C	c.(922-924)tAc>tCc	p.Y308S	HTR3A_ENST00000355556.2_Missense_Mutation_p.Y346S|HTR3A_ENST00000535865.1_Missense_Mutation_p.Y52S|HTR3A_ENST00000506841.2_Missense_Mutation_p.Y340S|HTR3A_ENST00000299961.5_Missense_Mutation_p.Y293S|HTR3A_ENST00000375498.2_Missense_Mutation_p.Y314S			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	308					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	ACAGGTGTCTACTTTGTGGTG	0.602000													22	156					0	0	1	0	0
F2RL3	9002	broad.mit.edu	37	19	17000696	17000696	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:17000696G>A	ENST00000248076.3	+	2	752	c.422G>A	c.(421-423)cGc>cAc	p.R141H	F2RL3_ENST00000599210.1_3'UTR	NM_003950.2	NP_003941.2	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	141					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity			cervix(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						CGTGGCCAGCGCTGGCCCTTC	0.711000													17	15					0	0	1	0	0
ZNF462	58499	broad.mit.edu	37	9	109691748	109691748	+	Missense_Mutation	SNP	T	T	G			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr9:109691748T>G	ENST00000277225.5	+	3	5844	c.5555T>G	c.(5554-5556)tTc>tGc	p.F1852C	ZNF462_ENST00000457913.1_Missense_Mutation_p.F1852C|ZNF462_ENST00000441147.2_Missense_Mutation_p.F697C			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1852					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						ATCAAATGCTTCAAGCTGTCC	0.532000													9	131					0	0	1	0	0
CLCN3	0	broad.mit.edu	37	4	170610267	170610267	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr4:170610267G>A	ENST00000513761.1	+	5	1051	c.492G>A	c.(490-492)gcG>gcA	p.A164A	CLCN3_ENST00000360642.3_Silent_p.A164A|CLCN3_ENST00000504131.2_Silent_p.A147A|CLCN3_ENST00000347613.4_Silent_p.A164A	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	164					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		GCCTTAGTGCGTTGTGGTACA	0.438000													79	88					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11182158	11182158	+	Missense_Mutation	SNP	A	A	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr1:11182158A>C	ENST00000361445.4	-	48	6764	c.6688T>G	c.(6688-6690)Tta>Gta	p.L2230V	MTOR_ENST00000376838.1_Missense_Mutation_p.L435V	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	2230	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TTGGTCGATAAAGGGATGACA	0.532000													33	8					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128350379	128350379	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:128350379G>A	ENST00000389524.4	+	17	2056	c.2003G>A	c.(2002-2004)cGg>cAg	p.R668Q	MYO7B_ENST00000409816.2_Missense_Mutation_p.R668Q|MYO7B_ENST00000428314.1_Missense_Mutation_p.R668Q			Q6PIF6	MYO7B_HUMAN	myosin VIIB	668	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTGTTCGACCGGGAGCTGTGC	0.687000													3	30					0	0	1	0	0
LHX5	64211	broad.mit.edu	37	12	113906197	113906197	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr12:113906197G>A	ENST00000261731.3	-	3	983	c.410C>T	c.(409-411)aCg>aTg	p.T137M		NM_022363.2	NP_071758.1	Q9H2C1	LHX5_HUMAN	LIM homeobox 5	137						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	10						ACTGCGGTCCGTACAGGATGA	0.662000													23	33					0	0	1	0	0
CSNK2B-LY6G5B-1181	0	broad.mit.edu	37	6	31636397	31636397	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr6:31636397G>A	ENST00000375880.2	+	4	375	c.257G>A	c.(256-258)cGc>cAc	p.R86H	CSNK2B_ENST00000375882.2_Missense_Mutation_p.R86H|CSNK2B_ENST00000375865.2_Missense_Mutation_p.R86H|CSNK2B_ENST00000375885.4_Missense_Mutation_p.R105H|CSNK2B_ENST00000375866.2_Missense_Mutation_p.R86H																							ATCCACGCCCGCTACATCCTT	0.552000													65	58					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9907313	9907313	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:9907313G>A	ENST00000380913.3	+	8	4308	c.4218G>A	c.(4216-4218)gcG>gcA	p.A1406A	SHROOM2_ENST00000418909.2_Silent_p.A241A	NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	1406	ASD2.				apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				CCCCCAAGGCGGAGCTGCTGA	0.597000													20	29					0	0	1	0	0
PCDHA3	0	broad.mit.edu	37	5	140180922	140180922	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr5:140180922G>A	ENST00000522353.2	+	1	140	c.140G>A	c.(139-141)cGc>cAc	p.R47H	PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.R47H|PCDHA1_ENST00000504120.2_Intron	NM_018906.2	NP_061729.1												p.R47P(2)		NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGTGGGCCGCATCGCGCAG	0.657000													5	282					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38888491	38888491	+	Silent	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr3:38888491G>A	ENST00000450244.1	-	26	5268	c.5070C>T	c.(5068-5070)acC>acT	p.T1690T	SCN11A_ENST00000456224.3_Silent_p.T1652T|SCN11A_ENST00000302328.3_Silent_p.T1690T			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1690					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GTACCCTAGCGGTGAAGGCGA	0.453000													140	142					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441273	99441273	+	Missense_Mutation	SNP	G	G	A			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr8:99441273G>A	ENST00000287042.4	+	2	1416	c.1066G>A	c.(1066-1068)Gag>Aag	p.E356K	KCNS2_ENST00000521839.1_Missense_Mutation_p.E356K	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	356						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGAGGAGAACGAGGGCCTGGC	0.577000													55	83					0	0	1	0	0
PDIA5	10954	broad.mit.edu	37	3	122849400	122849400	+	Missense_Mutation	SNP	G	G	A	rs145568670		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr3:122849400G>A	ENST00000316218.7	+	11	942	c.847G>A	c.(847-849)Gat>Aat	p.D283N		NM_006810.3	NP_006801.1	Q14554	PDIA5_HUMAN	protein disulfide isomerase family A, member 5	283	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	21				GBM - Glioblastoma multiforme(114;0.0427)		TCACCTGACCGATGAAGACTT	0.587000													60	85					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7627946	7627946	+	Silent	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr10:7627946T>C	ENST00000256861.6	-	8	1104	c.1026A>G	c.(1024-1026)gtA>gtG	p.V342V	ITIH5_ENST00000397146.2_Silent_p.V342V|ITIH5_ENST00000298441.6_Silent_p.V128V|ITIH5_ENST00000446830.2_Silent_p.V124V|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.V342V	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	342	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						GGTCCTTCCATACTTTGATCC	0.473000													40	59					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196309662	196309662	+	Missense_Mutation	SNP	T	T	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr1:196309662T>C	ENST00000367433.5	-	16	1693	c.1592A>G	c.(1591-1593)aAt>aGt	p.N531S	KCNT2_ENST00000294725.8_Missense_Mutation_p.N531S|KCNT2_ENST00000451324.2_Missense_Mutation_p.N142S|KCNT2_ENST00000367431.4_Missense_Mutation_p.N481S|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	531	RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AATGTTTTTATTATCCTCCCT	0.303000													23	138					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145109975	145109976	+	RNA	INS	-	-	C	rs67257307		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr1:145109975_145109976insC	ENST00000453618.1	+	0	673							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										CAGGAACTTTGCTAAAGATCTA	0.386													3	5	---	---	---	---					
PSME4	23198	broad.mit.edu	37	2	54167139	54167140	+	Splice_Site	INS	-	-	G			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr2:54167139_54167140insG	ENST00000404125.1	-	4	556		c.e4-2		PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding	p.?(1)		breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCTACAGAACTGGGGGGGGAAA	0.347													9	291	---	---	---	---					
CTD-2324F15.2	0	broad.mit.edu	37	5	6337066	6337067	+	RNA	DEL	AC	AC	-			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr5:6337066_6337067delAC	ENST00000507444.1	-	0	143					NR_028351.1																						acacatacatacacacacacac	0.475													4	9	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150816	65150817	+	RNA	INS	-	-	C			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr7:65150816_65150817insC	ENST00000430126.2	+	0	757																											TTCATCCCTCACCCCCCCCCCC	0.465													5	6	---	---	---	---					
AKAP9	10142	broad.mit.edu	37	7	91630393	91630396	+	Frame_Shift_Del	DEL	AGAC	AGAC	-	rs146864466		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr7:91630393_91630396delAGAC	ENST00000359028.2	+	9	1423_1426	c.1198_1201delAGAC	c.(1198-1203)agfs	p.RQ400fs	AKAP9_ENST00000358100.2_Frame_Shift_Del_p.RQ400fs|AKAP9_ENST00000356239.3_Frame_Shift_Del_p.RQ388fs			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	400	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding	p.R400K(1)|p.R388K(1)		NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			gcaaaaagaaagacagtcttctga	0.328			T	BRAF	papillary thyroid								15	48	---	---	---	---					
RP11-262H14.3	0	broad.mit.edu	37	9	66545704	66545704	+	RNA	DEL	C	C	-	rs12353356		TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr9:66545704delC	ENST00000445604.2	-	0	669																											GAAAAAAAAACAAAGAAAGAA	0.373													4	7	---	---	---	---					
HNRNPK	3190	broad.mit.edu	37	9	86588288	86588289	+	Frame_Shift_Del	DEL	AA	AA	-			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr9:86588288_86588289delAA	ENST00000376263.3	-	9	651_652	c.428_429delTT	c.(427-429)tfs	p.F143fs	RP11-575L7.8_ENST00000448389.1_RNA|HNRNPK_ENST00000376264.2_Frame_Shift_Del_p.F143fs|HNRNPK_ENST00000376281.4_Frame_Shift_Del_p.F143fs|HNRNPK_ENST00000351839.3_Frame_Shift_Del_p.F143fs|HNRNPK_ENST00000360384.5_Frame_Shift_Del_p.F143fs	NM_031263.2	NP_112553.1	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	143	2 X 22 AA approximate repeats.|5 X 4 AA repeats of G-X-G-G.|Interaction with ASFV p30.|Necessary for interaction with DDX1.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|skin(1)|stomach(1)	19						ACTCGCAGTCAAAGTCACTTCC	0.366													26	288	---	---	---	---					
NOTCH1	4851	broad.mit.edu	37	9	139412283	139412285	+	In_Frame_Del	DEL	GTT	GTT	-			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr9:139412283_139412285delGTT	ENST00000277541.6	-	8	1435_1437	c.1360_1362delAAC	c.(1360-1362)del	p.N454del		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	454	EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.N454delN(2)		breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGACGCACTCGTTGACGTCGATC	0.660			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			66	85	---	---	---	---					
ANO8	57719	broad.mit.edu	37	19	17439421	17439422	+	In_Frame_Ins	INS	-	-	TCC			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr19:17439421_17439422insTCC	ENST00000159087.4	-	13	1933_1934	c.1775_1776insGGA	c.(1774-1776)gga>gGGAga	p.592_593insR		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	592	Glu-rich.					chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						cttcctcctcgtcctcctcctc	0.743													2	4	---	---	---	---					
USP25	29761	broad.mit.edu	37	21	17203875	17203876	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chr21:17203875_17203876delTT	ENST00000285681.2	+	16	2289_2290	c.1920_1921delTT	c.(1918-1923)tcttfs	p.SF640fs	USP25_ENST00000285679.6_Frame_Shift_Del_p.SF640fs|USP25_ENST00000400183.2_Frame_Shift_Del_p.SF640fs|USP25_ENST00000351097.5_Intron			Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	640					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(4)|endometrium(6)|kidney(2)|large_intestine(13)|liver(5)|lung(14)|ovary(4)|prostate(1)|skin(1)|urinary_tract(2)	52				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TGAGGGACTCTTTTGGTGGTTA	0.366													72	139	---	---	---	---					
GAGE2A	729447	broad.mit.edu	37	X	49355814	49355816	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-VW-A7QS-01A-12D-A33T-08	TCGA-VW-A7QS-10A-02D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	956e5346-11d4-4d05-8ba1-404e24662ec2	3f4313bf-c69c-4fc2-9951-7886601a95db	g.chrX:49355814_49355816delTGA	ENST00000362097.1	+	3	179_181	c.96_98delTGA	c.(94-99)agt>ag	p.SD32del		NM_001127212.1	NP_001120684.1			G antigen 2A											endometrium(4)	4	Ovarian(276;0.236)					AGCAGTTCAGTGATGAAGTGGAA	0.453													15	1285	---	---	---	---