Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TNFRSF4	7293	broad.mit.edu	37	1	1148430	1148430	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:1148430G>A	uc001ade.2	-	3	317	c.312C>T	c.(310-312)GAC>GAT	p.D104D	TNFRSF4_uc001adf.2_Silent_p.D108D	NM_003327	NP_003318	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily,	104	TNFR-Cys 2.|Extracellular (Potential).				immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGCAGACTGTGTCCTGTGTGG	0.692			NA											5	28					0	0	0.004482	0	0
FAM132A	388581	broad.mit.edu	37	1	1178014	1178014	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:1178014C>A	uc001adl.1	-	8	855	c.823G>T	c.(823-825)GCT>TCT	p.A275S		NM_001014980	NP_001014980	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	275						extracellular region					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AACACAGAAGCGTACTGTCCA	0.672			NA											3	8					6.4e-05	7.32707e-05	0.004672	1	0
ACAP3	116983	broad.mit.edu	37	1	1237394	1237394	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:1237394C>A	uc001aeb.2	-	5	386	c.312G>T	c.(310-312)CGG>CGT	p.R104R	ACAP3_uc001aea.2_Silent_p.R62R|ACAP3_uc001aec.1_Silent_p.R62R	NM_030649	NP_085152	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH	104					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding				0						GGAGCTGCTGCCGCACGGACC	0.652			NA											4	90					5.9392e-07	7.45051e-07	0.001168	1	0
ACTRT2	140625	broad.mit.edu	37	1	2938683	2938683	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:2938683G>A	uc001ajz.2	+	1	638	c.433G>A	c.(433-435)GCT>ACT	p.A145T		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	145						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GGCGGTGCTGGCTCTCTACGC	0.632			NA											8	52					0	0	0.00308	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631143	6631143	+	Silent	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:6631143A>T	uc001ant.2	+	2	366	c.366A>T	c.(364-366)CCA>CCT	p.P122P	TAS1R1_uc001anu.2_Silent_p.P122P|TAS1R1_uc001anv.2_Silent_p.P122P|TAS1R1_uc001anw.2_Silent_p.P122P	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	122	Extracellular (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TCTCCCTGCCAGGGCAACACC	0.587			NA											14	179					0	0	0.003163	0	0
SPEN	23013	broad.mit.edu	37	1	16265829	16265829	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:16265829C>T	uc001axk.1	+	15	11106	c.10902C>T	c.(10900-10902)TTC>TTT	p.F3634F	SPEN_uc010obp.1_Silent_p.F3593F	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3634	SPOC.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTGTGAGTTCTCTGAGAGTC	0.582			NA											74	135					0	0	0.00361	0	0
TAS1R2	80834	broad.mit.edu	37	1	19186147	19186147	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:19186147G>T	uc001bba.1	-	1	9	c.8C>A	c.(7-9)CCC>CAC	p.P3H		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	3					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CTTTGCCCTGGGCCCCATGGC	0.562			NA											9	66					1.58986e-06	1.92151e-06	0.008291	1	0
RHD	6007	broad.mit.edu	37	1	25627475	25627475	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:25627475C>A	uc001bjz.2	+	4	583	c.525C>A	c.(523-525)TTC>TTA	p.F175L	RHD_uc010oep.1_Missense_Mutation_p.F175L|RHD_uc001bkc.2_Missense_Mutation_p.F175L|RHD_uc009vrm.2_Missense_Mutation_p.F7L|RHD_uc001bka.2_Missense_Mutation_p.F175L|RHD_uc001bkb.2_Missense_Mutation_p.F175L|RHD_uc009vrn.2_Missense_Mutation_p.F175L|RHD_uc009vro.2_Missense_Mutation_p.F175L|RHD_uc009vrp.2_Missense_Mutation_p.F175L	NM_016124	NP_057208	Q02161	RHD_HUMAN	Rh blood group D antigen isoform 1	175	Helical; (Potential).					integral to plasma membrane				breast(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCTACGTGTTCGCAGCCTATT	0.532			NA											25	152					9.86323e-18	1.53976e-17	0.003954	1	0
CSMD2	114784	broad.mit.edu	37	1	34258067	34258067	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:34258067C>T	uc001bxn.1	-	11	1416	c.1387G>A	c.(1387-1389)GGT>AGT	p.G463S	CSMD2_uc001bxm.1_Missense_Mutation_p.G503S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	463	CUB 3.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCACCATCACCGACCGTCAGG	0.572			NA											30	65					0	0	0.002096	0	0
POMGNT1	55624	broad.mit.edu	37	1	46658031	46658031	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:46658031C>T	uc001cpe.2	-	16	1526	c.1362G>A	c.(1360-1362)AGG>AGA	p.R454R	POMGNT1_uc010olx.1_Silent_p.R432R|POMGNT1_uc010oly.1_RNA|POMGNT1_uc010olz.1_Silent_p.R311R|POMGNT1_uc001cpg.2_Silent_p.R454R|POMGNT1_uc001cpf.2_Silent_p.R121R|POMGNT1_uc001cph.1_Silent_p.R32R|POMGNT1_uc001cpi.1_Silent_p.R121R	NM_017739	NP_060209	Q8WZA1	PMGT1_HUMAN	O-linked mannose	454	Lumenal (Potential).				protein N-linked glycosylation|protein O-linked glycosylation	Golgi membrane|integral to membrane|microsome	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					ACAAGGACCTCCTGAGCACCC	0.602			NA											9	68					0	0	0.004482	0	0
LRRC42	115353	broad.mit.edu	37	1	54417792	54417792	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:54417792G>T	uc001cwj.1	+	2	320	c.120G>T	c.(118-120)AAG>AAT	p.K40N	LRRC42_uc001cwl.1_Missense_Mutation_p.K40N|LRRC42_uc001cwk.1_Missense_Mutation_p.K40N|LRRC42_uc009vzm.1_Missense_Mutation_p.K40N	NM_052940	NP_443172	Q9Y546	LRC42_HUMAN	leucine rich repeat containing 42	40											0						GCCTGCAGAAGCCAAGGCCTT	0.517			NA											30	72					2.85442e-18	4.46847e-18	0.002096	1	0
FAM151A	338094	broad.mit.edu	37	1	55080475	55080475	+	Missense_Mutation	SNP	C	C	T	rs150113940	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:55080475C>T	uc001cxn.2	-	4	605	c.473G>A	c.(472-474)CGG>CAG	p.R158Q	ACOT11_uc001cxm.1_Intron	NM_176782	NP_788954	Q8WW52	F151A_HUMAN	hypothetical protein LOC338094	158						integral to membrane					0						TGTCAGCTGCCGCAGGAGGTC	0.557			NA											5	59					0	0	0.001168	0	0
C1orf168	199920	broad.mit.edu	37	1	57257990	57257990	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:57257990C>A	uc001cym.3	-	2	902	c.496G>T	c.(496-498)GCC>TCC	p.A166S	C1orf168_uc009vzu.1_RNA|C1orf168_uc009vzv.1_Missense_Mutation_p.A166S	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	166										ovary(3)|skin(2)	5						AGATGGATGGCCTTACTTCCA	0.483			NA											6	121					0.00116845	0.00125798	0.001168	1	0
PDE4B	5142	broad.mit.edu	37	1	66713283	66713283	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:66713283A>T	uc001dcn.2	+	4	613	c.422A>T	c.(421-423)GAC>GTC	p.D141V	PDE4B_uc009war.2_Missense_Mutation_p.D49V|PDE4B_uc001dco.2_Missense_Mutation_p.D141V|PDE4B_uc001dcp.2_Missense_Mutation_p.D126V	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	141					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	TCAGACAGCGACTATGACTTG	0.527			NA											25	132					0	0	0.003954	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098198	78098198	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:78098198T>C	uc001dhq.2	-	5	1318	c.842A>G	c.(841-843)AAA>AGA	p.K281R	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.K281R|ZZZ3_uc001dhp.2_Missense_Mutation_p.K281R	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						AGTTACTATTTTGTGGTCCTC	0.443			NA											55	91					0	0	0.00361	0	0
GBP6	163351	broad.mit.edu	37	1	89846073	89846073	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:89846073G>A	uc001dnf.2	+	6	1028	c.754G>A	c.(754-756)GTG>ATG	p.V252M	GBP6_uc010ost.1_Missense_Mutation_p.V122M	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	252							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		TATTGAGAAGGTGTCAGAAAA	0.438			NA											7	48					0	0	0.001984	0	0
EVI5	7813	broad.mit.edu	37	1	93131509	93131509	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:93131509T>A	uc001dox.2	-	11	1341	c.1331A>T	c.(1330-1332)GAG>GTG	p.E444V	EVI5_uc010otf.1_Missense_Mutation_p.E444V|EVI5_uc001doy.1_RNA	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	444	Dimerization.|Targeting to the centrosomes.|Potential.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		TTCTAATGTCTCGATGCGCTG	0.313			NA											9	65					0	0	0.008291	0	0
DPYD	1806	broad.mit.edu	37	1	97981448	97981448	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:97981448T>C	uc001drv.2	-	13	1711	c.1574A>G	c.(1573-1575)TAC>TGC	p.Y525C		NM_000110	NP_000101	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase isoform 1	525					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			ovary(3)|skin(3)|breast(2)	8		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AATAGGAGTGTAAAAGAGGGG	0.413			NA											23	42					0	0	0.002299	0	0
AP4B1	10717	broad.mit.edu	37	1	114437980	114437980	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:114437980G>C	uc001eeb.2	-	10	2070	c.1927C>G	c.(1927-1929)CAG>GAG	p.Q643E	uc001edv.1_Intron|AP4B1_uc001eec.2_Missense_Mutation_p.Q475E|AP4B1_uc001eed.2_Missense_Mutation_p.Q643E|AP4B1_uc010owp.1_Missense_Mutation_p.Q544E|AP4B1_uc001eea.1_3'UTR|AP4B1_uc001eee.1_3'UTR	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	643					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AACACTTGCTGATGAGCAACT	0.498			NA											5	133					0	0	0.001984	0	0
SYCP1	6847	broad.mit.edu	37	1	115487071	115487071	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:115487071G>T	uc001efr.2	+	24	2247	c.2038G>T	c.(2038-2040)GAA>TAA	p.E680*	SYCP1_uc010owt.1_RNA|SYCP1_uc001efq.2_Nonsense_Mutation_p.E680*|SYCP1_uc009wgw.2_Nonsense_Mutation_p.E680*	NM_003176	NP_003167	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	680	Nuclear localization signal (Potential).|Potential.				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding			skin(1)	1	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAATCTTTTGGAAGAGGTGGG	0.269			NA											12	42					1.61879e-10	2.23528e-10	0.001368	1	0
FLG2	388698	broad.mit.edu	37	1	152325739	152325739	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:152325739T>C	uc001ezw.3	-	3	4596	c.4523A>G	c.(4522-4524)GAA>GGA	p.E1508G	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1508	Filaggrin 5.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGAGTGCACTTCACTGTCACT	0.502			NA											13	814					0	0	0.001855	0	0
FLG2	388698	broad.mit.edu	37	1	152329152	152329152	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:152329152C>A	uc001ezw.3	-	3	1183	c.1110G>T	c.(1108-1110)TGG>TGT	p.W370C	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	370	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCTGTTCTCCATTGTCCTC	0.483			NA											55	124					1.63038e-21	2.62542e-21	0.00361	1	0
SCAMP3	10067	broad.mit.edu	37	1	155226464	155226464	+	Splice_Site	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:155226464C>G	uc001fjs.2	-	8	1150	c.897_splice	c.e8+1	p.R299_splice	RAG1AP1_uc010pey.1_Intron|FAM189B_uc001fjm.2_5'Flank|FAM189B_uc001fjn.2_5'Flank|FAM189B_uc001fjo.2_5'Flank|FAM189B_uc001fjp.2_5'Flank|FAM189B_uc001fjq.1_5'Flank|SCAMP3_uc001fjr.2_Splice_Site_p.R146_splice|SCAMP3_uc001fju.2_Splice_Site_p.R285_splice|SCAMP3_uc001fjv.2_Splice_Site|SCAMP3_uc001fjt.2_Splice_Site_p.R273_splice	NM_005698	NP_005689	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3 isoform 1						post-Golgi vesicle-mediated transport|protein transport	integral to membrane				ovary(3)	3	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			ACAGCCCTCACCCGTTTCAGC	0.607			NA											10	75					0	0	0.006214	0	0
UBQLN4	56893	broad.mit.edu	37	1	156020953	156020953	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:156020953C>A	uc001fna.2	-	3	450	c.426G>T	c.(424-426)GGG>GGT	p.G142G	UBQLN4_uc010pgx.1_Intron	NM_020131	NP_064516	Q9NRR5	UBQL4_HUMAN	ataxin-1 ubiquitin-like interacting protein	142						cytosol|endoplasmic reticulum membrane|nucleus	identical protein binding			pancreas(1)|skin(1)	2	Hepatocellular(266;0.133)|all_neural(408;0.195)					CCGGAGAGGGCCCCCCACCAC	0.647			NA											15	28					1.5739e-10	2.19486e-10	0.004007	1	0
FCRL2	79368	broad.mit.edu	37	1	157738381	157738381	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:157738381T>A	uc001fre.2	-	5	765	c.706A>T	c.(706-708)ACA>TCA	p.T236S	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Missense_Mutation_p.T236S|FCRL2_uc009wsp.2_Intron	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	236	Ig-like C2-type 3.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CAGGAGAATGTGACATTTCCT	0.542			NA											92	211					0	0	0.00361	0	0
CD1B	910	broad.mit.edu	37	1	158300661	158300661	+	Missense_Mutation	SNP	C	C	G	rs149817745	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:158300661C>G	uc001frx.2	-	2	361	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	CD1B_uc001frw.2_5'UTR|CD1B_uc010pic.1_Missense_Mutation_p.E85Q	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	85	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					AATATCTCCTCTAACTCAGCA	0.458			NA											67	624					0	0	0.00361	0	0
SPTA1	6708	broad.mit.edu	37	1	158647525	158647525	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:158647525G>T	uc001fst.1	-	7	1111	c.912C>A	c.(910-912)CAC>CAA	p.H304Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	304	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CCTTGTGACTGTGAAACAGTC	0.478			NA											7	109					8.12818e-05	9.24704e-05	0.001984	1	0
OR6N1	128372	broad.mit.edu	37	1	158735770	158735770	+	Silent	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:158735770T>G	uc010piq.1	-	1	703	c.703A>C	c.(703-705)AGG>CGG	p.R235R		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	235	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ATGGCCTTCCTCTTGCCGGCA	0.507			NA											12	184					0	0	0.000978	0	0
IFI16	3428	broad.mit.edu	37	1	159002405	159002405	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:159002405G>A	uc001ftg.2	+	7	1543	c.1253G>A	c.(1252-1254)AGC>AAC	p.S418N	IFI16_uc010pis.1_Missense_Mutation_p.S362N|IFI16_uc001fth.2_Missense_Mutation_p.S17N|IFI16_uc010pit.1_Missense_Mutation_p.S17N	NM_005531	NP_005522	Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	418					cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)					TCAGAGGCCAGCACAACCTTC	0.493			NA											21	70					0	0	0.003271	0	0
CADM3	57863	broad.mit.edu	37	1	159163316	159163316	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:159163316G>T	uc001ftl.2	+	4	628	c.486G>T	c.(484-486)CGG>CGT	p.R162R	CADM3_uc009wsx.1_Silent_p.R196R|CADM3_uc009wsy.1_Silent_p.R162R|CADM3_uc001ftk.2_Silent_p.R196R	NM_001127173	NP_001120645	Q8N126	CADM3_HUMAN	cell adhesion molecule 3 isoform 2	162	Ig-like C2-type 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			ovary(2)	2	all_hematologic(112;0.0429)					CTGCAGCCCGGCTCACCTGGA	0.517			NA											33	70					2.46105e-21	3.94049e-21	0.002096	1	0
PPOX	5498	broad.mit.edu	37	1	161138874	161138875	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:161138874_161138875GC>AT	uc001fyj.2	+	7	998_999	c.708_709GC>AT	c.(706-711)TTGCCT>TTATCT	p.P237S	PPOX_uc001fyn.2_Intron|PPOX_uc001fyg.2_Missense_Mutation_p.P237S|PPOX_uc001fyl.2_Missense_Mutation_p.P203S|PPOX_uc001fym.2_RNA|PPOX_uc001fyk.2_Missense_Mutation_p.P75S|PPOX_uc001fyh.2_Missense_Mutation_p.P75S|PPOX_uc010pkg.1_Missense_Mutation_p.P75S|PPOX_uc009wuc.1_Missense_Mutation_p.P75S|PPOX_uc010pkh.1_Intron|PPOX_uc001fyi.2_Missense_Mutation_p.P75S	NM_001122764	NP_001116236	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	237					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			ovary(1)	1	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TAGAGATGTTGCCTCAGGCCCT	0.629			NA							Porphyria_Variegata				53	90					0	0	0.004672	0	0
TNR	7143	broad.mit.edu	37	1	175334328	175334328	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:175334328T>A	uc001gkp.1	-	10	2486	c.2405A>T	c.(2404-2406)GAC>GTC	p.D802V	TNR_uc009wwu.1_Missense_Mutation_p.D802V	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	802	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					AATGAGTCTGTCTGCTGGGGG	0.532			NA											20	65					0	0	0.008871	0	0
CEP350	9857	broad.mit.edu	37	1	180047644	180047644	+	Silent	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:180047644A>G	uc001gnt.2	+	29	6197	c.5814A>G	c.(5812-5814)CTA>CTG	p.L1938L	CEP350_uc009wxl.2_Silent_p.L1937L|CEP350_uc001gnv.2_Silent_p.L73L	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1938						centrosome|nucleus|spindle				ovary(4)	4						ACTCTCATCTAAACAGTGAAA	0.433			NA											11	50					0	0	0.000978	0	0
CACNA1E	777	broad.mit.edu	37	1	181701955	181701955	+	Silent	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:181701955G>C	uc001gow.2	+	20	2898	c.2733G>C	c.(2731-2733)CGG>CGC	p.R911R	CACNA1E_uc009wxs.2_Silent_p.R799R|CACNA1E_uc001gox.1_Silent_p.R137R|CACNA1E_uc009wxt.2_Silent_p.R137R	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	911	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TTGAGGACCGGGCCAGGCACA	0.672			NA											10	159					0	0	0.008291	0	0
CACNA1E	777	broad.mit.edu	37	1	181745260	181745260	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:181745260C>A	uc001gow.2	+	38	5328	c.5163C>A	c.(5161-5163)GTC>GTA	p.V1721V	CACNA1E_uc009wxs.2_Silent_p.V1609V|CACNA1E_uc001gox.1_Silent_p.V947V|CACNA1E_uc009wxt.2_Silent_p.V947V	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1721	IV.|Helical; Name=S6 of repeat IV.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TTGTGGCCGTCATCATGGACA	0.552			NA											25	443					3.73148e-12	5.41884e-12	0.007291	1	0
CACNA1E	777	broad.mit.edu	37	1	181745334	181745334	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:181745334G>A	uc001gow.2	+	38	5402	c.5237G>A	c.(5236-5238)CGC>CAC	p.R1746H	CACNA1E_uc009wxs.2_Missense_Mutation_p.R1634H|CACNA1E_uc001gox.1_Missense_Mutation_p.R972H|CACNA1E_uc009wxt.2_Missense_Mutation_p.R972H	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1746	EF-hand.|Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GAGTTTGTCCGCGTCTGGGCA	0.607			NA											23	281					0	0	0.002299	0	0
C1orf26	54823	broad.mit.edu	37	1	185159774	185159774	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:185159774C>T	uc001grg.3	+	10	1637	c.1523C>T	c.(1522-1524)ACG>ATG	p.T508M	C1orf26_uc001grh.3_Missense_Mutation_p.T508M	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	508	PINc.										0						ATTCTGTGCACGTGAGTTTCA	0.308			NA											31	59					0	0	0.008361	0	0
F13B	2165	broad.mit.edu	37	1	197032176	197032176	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:197032176C>G	uc001gtt.1	-	2	120	c.76G>C	c.(76-78)GGT>CGT	p.G26R		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	26	Sushi 1.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						TGAGGAAAACCACAGGGTTTC	0.294			NA											80	249					0	0	0.00361	0	0
CNTN2	6900	broad.mit.edu	37	1	205039560	205039560	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:205039560G>T	uc001hbr.2	+	19	2707	c.2438G>T	c.(2437-2439)AGG>ATG	p.R813M	CNTN2_uc001hbq.1_Missense_Mutation_p.R704M|CNTN2_uc001hbs.2_Missense_Mutation_p.R601M	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	813	Fibronectin type-III 3.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CCAGAGCCCAGGGTGGCCCCT	0.582	Melanoma(183;2548 2817 37099 41192)		NA											16	29					4.14922e-12	5.97913e-12	0.004007	1	0
DSTYK	25778	broad.mit.edu	37	1	205133027	205133027	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:205133027T>A	uc001hbw.2	-	4	1445	c.1381A>T	c.(1381-1383)ATC>TTC	p.I461F	DSTYK_uc001hbx.2_Missense_Mutation_p.I461F|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	461						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						ATCTGTCGGATGCAGCATTTG	0.483			NA											16	248					0	0	0.006122	0	0
CR1	1378	broad.mit.edu	37	1	207679324	207679324	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:207679324G>T	uc001hfy.2	+	2	337	c.197G>T	c.(196-198)GGG>GTG	p.G66V	CR1_uc009xcl.1_Missense_Mutation_p.G66V|CR1_uc001hfx.2_Missense_Mutation_p.G66V|CR1_uc010psg.1_Missense_Mutation_p.G66V|CR1_uc009xcj.1_Missense_Mutation_p.G66V|CR1_uc009xck.1_Missense_Mutation_p.G66V	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	66	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTTCCCATTGGGACATATCTG	0.468			NA											68	155					4.83677e-39	8.33824e-39	0.00361	1	0
CR1	1378	broad.mit.edu	37	1	207751547	207751547	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:207751547G>T	uc001hfy.2	+	21	3725	c.3585G>T	c.(3583-3585)AGG>AGT	p.R1195S	CR1_uc009xcl.1_Missense_Mutation_p.R745S|CR1_uc001hfx.2_Missense_Mutation_p.R1645S	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	1195	Extracellular (Potential).|Sushi 19.|Sushi 18.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						GCTGCTCCAGGGGTGAGTCTG	0.537			NA											15	194					1.3612e-06	1.65584e-06	0.003163	1	0
CENPF	1063	broad.mit.edu	37	1	214820636	214820636	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:214820636A>G	uc001hkm.2	+	13	7897	c.7723A>G	c.(7723-7725)AAA>GAA	p.K2575E		NM_016343	NP_057427	P49454	CENPF_HUMAN	centromere protein F	2671	Potential.|Sufficient for self-association.|Sufficient for centromere localization.				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			ovary(6)|central_nervous_system(4)|large_intestine(2)|skin(1)	13				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GCTACAATCCAAAAATGCCTC	0.418	Colon(80;575 1284 11000 14801 43496)		NA											4	67					0	0	0.009096	0	0
URB2	9816	broad.mit.edu	37	1	229779310	229779310	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:229779310A>T	uc001hts.1	+	5	3801	c.3665A>T	c.(3664-3666)GAT>GTT	p.D1222V	URB2_uc009xfd.1_Missense_Mutation_p.D1222V	NM_014777	NP_055592	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog	1222						nucleolus				central_nervous_system(2)|ovary(1)	3						GTCACTCAGGATATTGAGCCT	0.453			NA											8	182					0	0	0.004482	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232581492	232581492	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:232581492T>C	uc001hvg.2	-	9	3294	c.3136A>G	c.(3136-3138)AAA>GAA	p.K1046E	SIPA1L2_uc001hvf.2_Missense_Mutation_p.K120E	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1046					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CTGTCGAGTTTATATTCCACC	0.582			NA											64	175					0	0	0.00361	0	0
RYR2	6262	broad.mit.edu	37	1	237656311	237656311	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:237656311C>A	uc001hyl.1	+	19	2005	c.1885C>A	c.(1885-1887)CAG>AAG	p.Q629K		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	629	Cytoplasmic (By similarity).|B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCGTTCTAACCAGCATCTCAT	0.418			NA											12	32					4.36969e-10	5.98967e-10	0.001855	1	0
RYR2	6262	broad.mit.edu	37	1	237951363	237951363	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:237951363C>A	uc001hyl.1	+	92	13524	c.13404C>A	c.(13402-13404)CAC>CAA	p.H4468Q		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4468					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCACACACACAGATACGGAG	0.378			NA											12	25					4.3838e-07	5.52398e-07	0.001855	1	0
PLD5	200150	broad.mit.edu	37	1	242511434	242511434	+	Silent	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:242511434T>A	uc001hzn.1	-	2	427	c.300A>T	c.(298-300)TCA>TCT	p.S100S	PLD5_uc001hzl.3_Silent_p.S38S|PLD5_uc001hzm.3_5'UTR|PLD5_uc001hzo.1_Missense_Mutation_p.Q6L			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	100						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			AATTTTTTTCTGAGAGTCCAT	0.453			NA											17	206					0	0	0.007413	0	0
C1orf101	257044	broad.mit.edu	37	1	244643077	244643077	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:244643077A>G	uc001iam.2	+	5	376	c.317A>G	c.(316-318)TAT>TGT	p.Y106C	C1orf101_uc001iak.1_5'UTR|C1orf101_uc001ial.2_Missense_Mutation_p.Y106C|C1orf101_uc010pym.1_5'UTR|C1orf101_uc010pyn.1_Missense_Mutation_p.Y109C	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	106	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			CTGTGGTACTATAGAGTTAGG	0.284			NA											13	125					0	0	0.001368	0	0
OR2G3	81469	broad.mit.edu	37	1	247769209	247769209	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:247769209G>T	uc010pyz.1	+	1	322	c.322G>T	c.(322-324)GGC>TGC	p.G108C		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCTGGCACTGGGCTCCACTGA	0.488			NA											138	306					7.47599e-62	1.31297e-61	0.00361	1	0
OR6F1	343169	broad.mit.edu	37	1	247875457	247875457	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:247875457C>G	uc001idj.1	-	1	601	c.601G>C	c.(601-603)GTG>CTG	p.V201L		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	201	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			ACAGCAATCACAAAGGCCACA	0.542			NA											28	166					0	0	0.00632	0	0
OR2T33	391195	broad.mit.edu	37	1	248436320	248436320	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:248436320G>T	uc010pzi.1	-	1	797	c.797C>A	c.(796-798)ACT>AAT	p.T266N		NM_001004695	NP_001004695	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T,	266	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GTCATGGTTAGTGGACCTATG	0.478			NA											105	245					1.70018e-41	2.95822e-41	0.00361	1	0
PRKCQ	5588	broad.mit.edu	37	10	6498720	6498720	+	Silent	SNP	C	C	A	rs55867019		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:6498720C>A	uc001ijj.1	-	15	1638	c.1563G>T	c.(1561-1563)GCG>GCT	p.A521A	PRKCQ_uc009xim.1_Silent_p.A521A|PRKCQ_uc001iji.1_Silent_p.A554A|PRKCQ_uc009xin.1_Silent_p.A485A|PRKCQ_uc010qax.1_Silent_p.A396A	NM_006257	NP_006248	Q04759	KPCT_HUMAN	protein kinase C, theta	521	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			ovary(3)|lung(2)|large_intestine(1)	6						TTCCAAAATCCGCGATCTTGA	0.418	Ovarian(50;572 1126 10530 25349 30594)		NA											25	50					9.22233e-05	0.000104706	0.004656	1	0
OPTN	10133	broad.mit.edu	37	10	13152401	13152401	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:13152401G>A	uc001ilu.1	+	5	732	c.294G>A	c.(292-294)ATG>ATA	p.M98I	OPTN_uc001ilv.1_Missense_Mutation_p.M98I|OPTN_uc001ilw.1_Missense_Mutation_p.M98I|OPTN_uc001ilx.1_Missense_Mutation_p.M98I|OPTN_uc001ily.1_Missense_Mutation_p.M98I|OPTN_uc010qbr.1_Missense_Mutation_p.M41I|OPTN_uc001ilz.1_Missense_Mutation_p.M98I	NM_001008213	NP_001008214	Q96CV9	OPTN_HUMAN	optineurin	98	Interaction with Rab8.|Potential.				cell death|Golgi ribbon formation|Golgi to plasma membrane protein transport|protein targeting to Golgi|signal transduction	perinuclear region of cytoplasm|trans-Golgi network	protein C-terminus binding			ovary(2)	2						AGCGTCTAATGGCCTTGAGTC	0.438			NA											4	43					0	0	0.009096	0	0
HSPA14	51182	broad.mit.edu	37	10	14894416	14894416	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:14894416T>G	uc001inf.2	+	8	761	c.620T>G	c.(619-621)GTC>GGC	p.V207G		NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	207					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						TCTCTCAGCGTCATGGAAGTT	0.348			NA											51	180					0	0	0.00361	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255798	15255798	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:15255798C>T	uc001iob.2	-	8	1796	c.1789G>A	c.(1789-1791)GTC>ATC	p.V597I		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	597	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GGCTGGCTGACATAGGAGTGG	0.562			NA											52	120					0	0	0.00361	0	0
ZNF485	220992	broad.mit.edu	37	10	44112635	44112635	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:44112635T>C	uc010qfc.1	+	5	1338	c.1144T>C	c.(1144-1146)TAT>CAT	p.Y382H	ZNF485_uc010qfd.1_Missense_Mutation_p.Y291H	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	382	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AGAAAAACCCTATCACTGTAA	0.433			NA											4	83					0	0	0.009096	0	0
HNRNPA3P1	10151	broad.mit.edu	37	10	44285350	44285350	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:44285350C>A	uc010qfe.1	-	1	516	c.486G>T	c.(484-486)CAG>CAT	p.Q162H		NR_002726				SubName: Full=cDNA FLJ52659, highly similar to Heterogeneous nuclear ribonucleoprotein A3; SubName: Full=cDNA, FLJ79333, highly similar to Heterogeneous nuclear ribonucleoprotein A3; SubName: Full=Heterogeneous nuclear ribonucleoprotein A3, isoform CRA_a;												0						TTTTTCCACTCTGCCTGTCTT	0.333			NA											22	51					4.35082e-09	5.8357e-09	0.010504	1	0
ALOX5	240	broad.mit.edu	37	10	45941036	45941036	+	Silent	SNP	C	C	A	rs28395861	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:45941036C>A	uc001jce.2	+	14	2025	c.1926C>A	c.(1924-1926)CTC>CTA	p.L642L	ALOX5_uc009xmt.2_Silent_p.L610L|ALOX5_uc010qfg.1_Silent_p.L585L	NM_000698	NP_000689	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	642	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			ovary(1)|pancreas(1)	2		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	GCAAGAACCTCGAGGCCATTG	0.542			NA											25	71					1.04121e-07	1.34211e-07	0.005443	1	0
A1CF	29974	broad.mit.edu	37	10	52595854	52595854	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:52595854G>A	uc001jjj.2	-	6	772	c.584C>T	c.(583-585)GCG>GTG	p.A195V	A1CF_uc010qhn.1_Missense_Mutation_p.A203V|A1CF_uc001jji.2_Missense_Mutation_p.A195V|A1CF_uc001jjh.2_Missense_Mutation_p.A203V|A1CF_uc010qho.1_Missense_Mutation_p.A203V|A1CF_uc009xov.2_Missense_Mutation_p.A195V	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	195	RRM 2.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						TTTCCTCCTCGCCATGGCAGC	0.488			NA											7	120					0	0	0.00308	0	0
UNC5B	219699	broad.mit.edu	37	10	73053217	73053217	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:73053217A>T	uc001jro.2	+	12	2273	c.1828A>T	c.(1828-1830)ACA>TCA	p.T610S	UNC5B_uc001jrp.2_Missense_Mutation_p.T599S	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	610	Cytoplasmic (Potential).|ZU5.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						CTGTGGACCCACAGGCCTCCT	0.627			NA											35	99					0	0	0.003755	0	0
POLR3A	11128	broad.mit.edu	37	10	79773421	79773421	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:79773421A>T	uc001jzn.2	-	11	1653	c.1559T>A	c.(1558-1560)CTT>CAT	p.L520H		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	520					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CATCAGAACAAGGGCCTCTGC	0.438			NA											7	161					0	0	0.001984	0	0
AGAP11	119385	broad.mit.edu	37	10	88769657	88769657	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:88769657G>T	uc001kee.2	+	12	2852	c.1648G>T	c.(1648-1650)GTG>TTG	p.V550L	AGAP11_uc001kef.2_Intron	NM_133447	NP_597704	Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase	550					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding				0						CGACGAGTGCGTGTAGTATCT	0.498			NA											28	140					4.92203e-23	8.08824e-23	0.00623	1	0
PI4K2A	55361	broad.mit.edu	37	10	99361691	99361691	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:99361691G>A	uc010qoy.1	+	2	648	c.289G>A	c.(289-291)GGG>AGG	p.G97R	DHDPSL_uc001kny.2_Missense_Mutation_p.G260R|DHDPSL_uc001knz.2_Missense_Mutation_p.G97R	NM_018425	NP_060895	Q9BTU6	P4K2A_HUMAN	phosphatidylinositol 4-kinase type 2 alpha	Error:Variant_position_missing_in_Q9BTU6_after_alignment					phosphatidylinositol biosynthetic process	cytoplasm|integral to plasma membrane|membrane raft	1-phosphatidylinositol 4-kinase activity|ATP binding|magnesium ion binding			lung(1)|skin(1)	2		Colorectal(252;0.162)		Epithelial(162;1.24e-10)|all cancers(201;1.2e-08)		GTGCTGCACGGGGCAATGGGA	0.677			NA											9	50					0	0	0.006214	0	0
CHUK	1147	broad.mit.edu	37	10	101964958	101964958	+	Splice_Site	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:101964958T>A	uc001kqp.2	-	12	1287	c.1232_splice	c.e12-1	p.V411_splice		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase						I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		TGTCCTGTACTATATACAAGA	0.398	Ovarian(159;52 1904 10536 35305 37148)		NA											5	106					0	0	0.001168	0	0
CCDC147	159686	broad.mit.edu	37	10	106214201	106214201	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:106214201G>T	uc001kyh.2	+	18	2666	c.2532G>T	c.(2530-2532)ATG>ATT	p.M844I		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	844										ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		CAGCACCCATGGATAACACCT	0.433			NA											38	183					1.67305e-13	2.46139e-13	0.00623	1	0
SORCS1	114815	broad.mit.edu	37	10	108380225	108380225	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:108380225G>A	uc001kym.2	-	20	2765	c.2757C>T	c.(2755-2757)GGC>GGT	p.G919G	SORCS1_uc001kyl.2_Silent_p.G919G|SORCS1_uc009xxs.2_Silent_p.G919G|SORCS1_uc001kyn.1_Silent_p.G919G|SORCS1_uc001kyo.2_Silent_p.G919G	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	919	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		AAGTGAGGGTGCCCACTTGGC	0.468			NA											11	125					0	0	0.008291	0	0
DOCK1	1793	broad.mit.edu	37	10	128821561	128821561	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:128821561G>T	uc001ljt.2	+	14	1426	c.1362G>T	c.(1360-1362)GTG>GTT	p.V454V	DOCK1_uc010qun.1_Silent_p.V475V	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	454	DHR-1.				apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		CGGTGTCTGTGTACGATGAGG	0.433			NA											15	340					1.37285e-15	2.08525e-15	0.004007	1	0
MKI67	4288	broad.mit.edu	37	10	129903152	129903152	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:129903152C>A	uc001lke.2	-	13	7147	c.6952G>T	c.(6952-6954)GGC>TGC	p.G2318C	MKI67_uc001lkf.2_Missense_Mutation_p.G1958C|MKI67_uc009yav.1_Missense_Mutation_p.G1893C|MKI67_uc009yaw.1_Missense_Mutation_p.G1468C	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2318	16 X 122 AA approximate repeats.|11.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTTTGAAGCCAGCCAGGTCT	0.502			NA											143	425					8.19216e-75	1.44326e-74	0.00361	1	0
LOC653544	653544	broad.mit.edu	37	10	135491123	135491123	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr10:135491123G>A	uc010qvi.1	+	1	845	c.734G>A	c.(733-735)GGC>GAC	p.G245D		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GCCCACACCGGCGCGTGGGGA	0.786			NA											4	30					0	0	0.008291	0	0
EIF4G2	1982	broad.mit.edu	37	11	10822111	10822111	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:10822111G>A	uc001mjc.2	-	17	2145	c.1728C>T	c.(1726-1728)CAC>CAT	p.H576H	EIF4G2_uc001mjb.2_Silent_p.H370H|EIF4G2_uc009ygf.2_Silent_p.H370H|EIF4G2_uc001mjd.2_Silent_p.H538H	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	576	MI.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		CAGGAAGAAAGTGTTTAGGAG	0.373			NA											70	77					0	0	0.00361	0	0
EHF	26298	broad.mit.edu	37	11	34680205	34680205	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:34680205G>T	uc001mvr.1	+	8	844	c.733G>T	c.(733-735)GTG>TTG	p.V245L	EHF_uc009yke.1_Missense_Mutation_p.V222L|EHF_uc009ykf.1_Missense_Mutation_p.V248L	NM_012153	NP_036285	Q9NZC4	EHF_HUMAN	ets homologous factor	245	ETS.				cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			ATCAGAGGCAGTGGCTCAGCT	0.458			NA											46	70					3.39706e-21	5.42371e-21	0.00361	1	0
PRDM11	56981	broad.mit.edu	37	11	45226314	45226314	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:45226314A>C	uc001myo.2	+	6	890	c.641A>C	c.(640-642)AAA>ACA	p.K214T		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	214	SET.			K -> E (in Ref. 1; AAF87244).						upper_aerodigestive_tract(1)	1						GACGAGACCAAAGCCAACTGG	0.542	NSCLC(118;1511 1736 6472 36603 43224)		NA											19	102					0	0	0.008871	0	0
OR5T2	219464	broad.mit.edu	37	11	56000616	56000616	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:56000616G>C	uc010rjc.1	-	1	46	c.46C>G	c.(46-48)CAT>GAT	p.H16D		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ACAACACCATGACTCAAGGGG	0.348			NA											18	102					0	0	0.010504	0	0
GLYATL2	219970	broad.mit.edu	37	11	58605840	58605840	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:58605840A>T	uc001nnd.3	-	3	211	c.80T>A	c.(79-81)GTA>GAA	p.V27E	GLYATL2_uc009ymq.2_Missense_Mutation_p.V27E	NM_145016	NP_659453	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	27						mitochondrion	glycine N-acyltransferase activity			ovary(1)|skin(1)	2		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	GGCGCCATATACCTACGATGC	0.418			NA											3	55					0	0	0.004672	0	0
C11orf66	220004	broad.mit.edu	37	11	61250221	61250221	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:61250221C>T	uc001nru.1	+	4	447	c.322C>T	c.(322-324)CGC>TGC	p.R108C	C11orf66_uc009ynq.1_Missense_Mutation_p.R108C	NM_145017	NP_659454	Q7Z5V6	CK066_HUMAN	IIIG9 protein	108										ovary(1)	1						CTGGAGCATGCGCCAGACCAG	0.672			NA									OREG0021002	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	21					0	0	0.010504	0	0
TSGA10IP	254187	broad.mit.edu	37	11	65714870	65714870	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:65714870T>A	uc001ogk.1	+	5	606	c.574T>A	c.(574-576)TCA>ACA	p.S192T	TSGA10IP_uc009yqw.1_RNA|TSGA10IP_uc009yqx.1_Intron	NM_152762	NP_689975	Q3SY00	T10IP_HUMAN	testis specific, 10 interacting protein	192											0						GGAGCTAGGATCAGAGCCCCC	0.642			NA											16	10					0	0	0.003163	0	0
SDHD	6392	broad.mit.edu	37	11	111959712	111959712	+	Silent	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:111959712A>T	uc001pmz.2	+	3	352	c.291A>T	c.(289-291)GCA>GCT	p.A97A	TIMM8B_uc001pmx.2_5'Flank|TIMM8B_uc001pmy.2_5'Flank	NM_003002	NP_002993	O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D	97	Helical; (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	CCCTGGCTGCAGCCCTCACTC	0.468			NA	Mis|N|F|S			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				63	56					0	0	0.00361	0	0
APOA4	337	broad.mit.edu	37	11	116691784	116691784	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:116691784G>A	uc001pps.1	-	3	1094	c.990C>T	c.(988-990)GGC>GGT	p.G330G		NM_000482	NP_000473			apolipoprotein A-IV precursor												0	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CCGCATGGGGGCCCAGTTTCT	0.592			NA											70	73					0	0	0.00361	0	0
IGSF9B	22997	broad.mit.edu	37	11	133789980	133789980	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr11:133789980C>A	uc001qgx.3	-	18	3871	c.3640G>T	c.(3640-3642)GGC>TGC	p.G1214C		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1214	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		TCAGGGGAGCCGGTGCGGGAG	0.701			NA											36	49					5.43694e-19	8.58303e-19	0.005524	1	0
EFCAB4B	84766	broad.mit.edu	37	12	3763466	3763466	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:3763466C>A	uc001qmj.2	-	10	1530	c.958G>T	c.(958-960)GAG>TAG	p.E320*	EFCAB4B_uc010sen.1_Nonsense_Mutation_p.E320*|EFCAB4B_uc010seo.1_Nonsense_Mutation_p.E320*|EFCAB4B_uc001qmi.1_RNA	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	320	Potential.				activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			GAAGTCCGCTCCAGCTCCCGG	0.572			NA											19	30					4.63292e-17	7.13343e-17	0.008871	1	0
TPI1	7167	broad.mit.edu	37	12	6979285	6979285	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:6979285C>T	uc001qrk.2	+	6	654	c.616C>T	c.(616-618)CGT>TGT	p.R206C	TPI1_uc010sfo.1_Missense_Mutation_p.R124C	NM_000365	NP_000356	P60174	TPIS_HUMAN	triosephosphate isomerase 1 isoform 1	206					fatty acid biosynthetic process|gluconeogenesis|glycolysis|pentose-phosphate shunt	cytosol	triose-phosphate isomerase activity				0						TCAGAGCACCCGTATCATTTA	0.572			NA									OREG0021638	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	106					0	0	0.001984	0	0
ATN1	1822	broad.mit.edu	37	12	7048172	7048172	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:7048172T>A	uc001qrw.1	+	7	3283	c.3046T>A	c.(3046-3048)TCC>ACC	p.S1016T	ATN1_uc001qrx.1_Missense_Mutation_p.S1016T	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	1016					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GCCTGACATGTCCTATGCTGA	0.667			NA											5	82					0	0	0.000602	0	0
A2M	2	broad.mit.edu	37	12	9243913	9243913	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:9243913A>G	uc001qvk.1	-	19	2466	c.2353T>C	c.(2353-2355)TCT>CCT	p.S785P	A2M_uc009zgk.1_Missense_Mutation_p.S635P	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	785					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GCTCGGAGAGAGGCAGTGGAA	0.552			NA											16	89					0	0	0.004007	0	0
PZP	5858	broad.mit.edu	37	12	9317851	9317851	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:9317851A>G	uc001qvl.2	-	19	2400	c.2371T>C	c.(2371-2373)TCT>CCT	p.S791P	PZP_uc009zgl.2_Missense_Mutation_p.S660P|PZP_uc010sgo.1_RNA|PZP_uc009zgm.1_Missense_Mutation_p.S123P	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						GCTCGGAGAGAGGCAGTGGAA	0.552	Melanoma(125;1402 1695 4685 34487 38571)		NA											23	73					0	0	0.002299	0	0
CLEC1A	51267	broad.mit.edu	37	12	10233927	10233927	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:10233927C>A	uc001qxb.2	-	3	384	c.300G>T	c.(298-300)TTG>TTT	p.L100F	CLEC1A_uc009zhf.2_Missense_Mutation_p.L12F|CLEC1A_uc001qxc.2_Missense_Mutation_p.L12F|CLEC1A_uc001qxd.2_Missense_Mutation_p.L57F|CLEC1A_uc010sgx.1_Intron	NM_016511	NP_057595	Q8NC01	CLC1A_HUMAN	C-type lectin-like receptor-1	100	Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane|intracellular	sugar binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2						GAAGAGATTGCAACTCTTGGG	0.423			NA											27	52					2.79863e-10	3.84555e-10	0.004656	1	0
RPL13AP20	387841	broad.mit.edu	37	12	13028751	13028751	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:13028751G>C	uc010sho.1	+	1	341	c.319G>C	c.(319-321)GGC>CGC	p.G107R		NR_003932				SubName: Full=Ribosomal protein L13a variant; Flags: Fragment;												0						GGTGTTTGACGGCATCCCACC	0.612			NA											3	13					0	0	0.004672	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21331534	21331534	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:21331534A>G	uc001req.3	+	6	610	c.506A>G	c.(505-507)TAC>TGC	p.Y169C		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	169	Helical; Name=4; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TCTGGGTCATACATGTGGATA	0.333			NA											27	63					0	0	0.005443	0	0
CNTN1	1272	broad.mit.edu	37	12	41323638	41323638	+	Silent	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:41323638A>G	uc001rmm.1	+	7	650	c.537A>G	c.(535-537)GTA>GTG	p.V179V	CNTN1_uc009zjy.1_Silent_p.V179V|CNTN1_uc001rmn.1_Silent_p.V168V|CNTN1_uc001rmo.2_Silent_p.V179V	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	179	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				AATTTCCTGTATTTATCACAA	0.363			NA											13	67					0	0	0.001368	0	0
DDN	23109	broad.mit.edu	37	12	49391858	49391858	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:49391858C>T	uc001rsv.1	-	2	819	c.801G>A	c.(799-801)GGG>GGA	p.G267G	uc001rsw.2_5'Flank	NM_015086	NP_055901	O94850	DEND_HUMAN	dendrin	267						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				large_intestine(1)	1						TCTTTGTGCGCCCTCCGTCTG	0.647			NA											14	83					0	0	0.004007	0	0
KRT74	121391	broad.mit.edu	37	12	52967091	52967091	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:52967091C>A	uc001sap.1	-	1	519	c.471G>T	c.(469-471)AAG>AAT	p.K157N		NM_175053	NP_778223	Q7RTS7	K2C74_HUMAN	keratin 6 irs4	157	Coil 1A.|Rod.					keratin filament	structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.191)		TGAGACCCACCTTGTCAATGA	0.592			NA											11	98					5.50884e-06	6.55925e-06	0.001368	1	0
TMTC3	160418	broad.mit.edu	37	12	88566501	88566501	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:88566501G>T	uc001tau.2	+	8	1398	c.1178G>T	c.(1177-1179)TGG>TTG	p.W393L	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	393	Helical; (Potential).					integral to membrane	binding			skin(1)	1						GCCCATGGATGGCAGAAAATA	0.343			NA											14	89					1.05317e-09	1.43661e-09	0.00245	1	0
KERA	11081	broad.mit.edu	37	12	91449623	91449623	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:91449623G>A	uc001tbl.2	-	2	1055	c.436C>T	c.(436-438)CAA>TAA	p.Q146*		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	146	LRR 4.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						AATTGTAATTGTTCTAAACTT	0.408			NA											14	148					0	0	0.001855	0	0
KERA	11081	broad.mit.edu	37	12	91449625	91449625	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:91449625T>C	uc001tbl.2	-	2	1053	c.434A>G	c.(433-435)GAA>GGA	p.E145G		NM_007035	NP_008966	O60938	KERA_HUMAN	keratocan precursor	145	LRR 4.				response to stimulus|visual perception	proteinaceous extracellular matrix				skin(1)	1						TTGTAATTGTTCTAAACTTCT	0.403			NA											14	148					0	0	0.00245	0	0
CCDC41	51134	broad.mit.edu	37	12	94794689	94794689	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:94794689A>C	uc001tdd.2	-	6	1072	c.486T>G	c.(484-486)TTT>TTG	p.F162L	CCDC41_uc001tde.2_Missense_Mutation_p.F162L|CCDC41_uc009zsw.1_RNA|CCDC41_uc001tdf.2_Missense_Mutation_p.F162L	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	NY-REN-58 antigen	154	Potential.										0						TCTGGTGTTCAAATTCTGACT	0.308			NA											14	116					0	0	0.00245	0	0
GAS2L3	283431	broad.mit.edu	37	12	101017690	101017690	+	Silent	SNP	C	C	A	rs149531123	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:101017690C>A	uc001thu.2	+	10	1333	c.1107C>A	c.(1105-1107)GTC>GTA	p.V369V	GAS2L3_uc009zty.2_Silent_p.V369V|GAS2L3_uc001thv.2_Silent_p.V265V	NM_174942	NP_777602	Q86XJ1	GA2L3_HUMAN	growth arrest-specific 2 like 3	369					cell cycle arrest					skin(1)	1						CTATGTCAGTCCGTTCTAAAT	0.453			NA											40	115					9.85913e-13	1.44292e-12	0.009718	1	0
CCDC53	51019	broad.mit.edu	37	12	102433651	102433651	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:102433651G>C	uc010svw.1	-	5	589	c.430C>G	c.(430-432)CAA>GAA	p.Q144E	CCDC53_uc010svx.1_RNA|CCDC53_uc010svy.1_RNA|CCDC53_uc010svz.1_Missense_Mutation_p.Q143E	NM_016053	NP_057137	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	144						WASH complex	protein binding				0						CTTACCACTTGAACCATTTTG	0.383			NA											21	169					0	0	0.00333	0	0
FZD10	11211	broad.mit.edu	37	12	130647951	130647951	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:130647951C>G	uc001uii.2	+	1	920	c.464C>G	c.(463-465)TCG>TGG	p.S155W	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	155	Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		AACAACGGCTCGGACGAGCCC	0.632			NA											4	67					0	0	0.009096	0	0
ULK1	8408	broad.mit.edu	37	12	132401562	132401562	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:132401562G>T	uc001uje.2	+	21	2405	c.2137G>T	c.(2137-2139)GAC>TAC	p.D713Y		NM_003565	NP_003556	O75385	ULK1_HUMAN	Unc-51-like kinase 1	713					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		ACAAGCCCCGGACCCGGGCAG	0.527			NA											29	68					5.45727e-16	8.3342e-16	0.008361	1	0
NBEA	26960	broad.mit.edu	37	13	35630253	35630253	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr13:35630253T>G	uc001uvb.2	+	8	1285	c.1079T>G	c.(1078-1080)GTT>GGT	p.V360G		NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	360						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GCTTGGCATGTTAACACAAAT	0.313			NA											17	50					0	0	0.00499	0	0
SETDB2	83852	broad.mit.edu	37	13	50038170	50038170	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr13:50038170A>C	uc001vcz.2	+	5	1128	c.222A>C	c.(220-222)AAA>AAC	p.K74N	SETDB2_uc010adg.2_Intron|SETDB2_uc001vcy.3_Intron|SETDB2_uc010adh.2_Intron|SETDB2_uc001vda.2_Intron	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	74					cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		catcacagaaagaagtgaatg	0.119			NA											7	12					0	0	0.00308	0	0
KLHL1	57626	broad.mit.edu	37	13	70681538	70681538	+	Silent	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr13:70681538T>A	uc001vip.2	-	1	1088	c.294A>T	c.(292-294)CCA>CCT	p.P98P	KLHL1_uc010thm.1_Silent_p.P98P|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	98					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TCGTGGCAACTGGAAGCAGGG	0.448			NA											15	40					0	0	0.00245	0	0
FOXG1	2290	broad.mit.edu	37	14	29237715	29237715	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr14:29237715C>T	uc001wqe.2	+	1	1429	c.1230C>T	c.(1228-1230)CTC>CTT	p.L410L		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	410					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCAACCTGCTCGCGGGCCAGA	0.682			NA											5	45					0	0	0.000602	0	0
KCNH5	27133	broad.mit.edu	37	14	63175029	63175029	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr14:63175029G>T	uc001xfx.2	-	11	2215	c.2164C>A	c.(2164-2166)CAG>AAG	p.Q722K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	722	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GTTGAGCCCTGATTCCGCAGC	0.577			NA											14	116					9.05144e-12	1.28783e-11	0.001855	1	0
DLK1	8788	broad.mit.edu	37	14	101201115	101201115	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr14:101201115A>C	uc001yhs.3	+	5	1187	c.1034A>C	c.(1033-1035)AAG>ACG	p.K345T	DLK1_uc001yhu.3_Missense_Mutation_p.K272T	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	345	Cytoplasmic (Potential).				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				ATGCTGCGGAAGAAGAAGAAC	0.577			NA											7	86					0	0	0.001984	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102452390	102452390	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr14:102452390C>T	uc001yks.2	+	8	1992	c.1828C>T	c.(1828-1830)CAG>TAG	p.Q610*		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	610	Interaction with DYNC1I2 (By similarity).|Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CCAGCTGATCCAGCGCGTGAA	0.507			NA											4	41					0	0	0.009096	0	0
OR4N3P	390539	broad.mit.edu	37	15	22414180	22414180	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:22414180G>T	uc001yuf.2	+	1	479	c.479G>T	c.(478-480)TGC>TTC	p.C160F		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						ATGTCCACATGCACCACCCAT	0.488			NA											29	186					9.78306e-22	1.58446e-21	0.009535	1	0
TJP1	7082	broad.mit.edu	37	15	30024944	30024944	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:30024944G>A	uc001zcr.2	-	14	2287	c.1812C>T	c.(1810-1812)TTC>TTT	p.F604F	TJP1_uc010azl.2_Silent_p.F592F|TJP1_uc001zcq.2_Silent_p.F608F|TJP1_uc001zcs.2_Silent_p.F604F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	604	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GAAGACCTCTGAATCTCCAGA	0.453	Melanoma(77;681 1843 6309 6570)		NA											23	40					0	0	0.001882	0	0
CHRNA7	1139	broad.mit.edu	37	15	32450697	32450697	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:32450697G>T	uc001zft.2	+	7	755	c.683G>T	c.(682-684)CGC>CTC	p.R228L	uc001zfv.1_Intron|CHRNA7_uc010bae.1_RNA|CHRNA7_uc010baf.2_Missense_Mutation_p.R47L|CHRNA7_uc010baj.1_Missense_Mutation_p.R88L|CHRNA7_uc010bak.2_Missense_Mutation_p.R143L	NM_000746	NP_000737	P36544	ACHA7_HUMAN	cholinergic receptor, nicotinic, alpha 7	228	Extracellular (Potential).				activation of MAPK activity|calcium ion transport|cellular calcium ion homeostasis|memory|negative regulation of tumor necrosis factor production|positive regulation of angiogenesis|positive regulation of cell proliferation|response to hypoxia|response to nicotine	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|beta-amyloid binding|chloride channel regulator activity|nicotinic acetylcholine-activated cation-selective channel activity|protein homodimerization activity|toxin binding			ovary(1)	1		all_lung(180;6.35e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)	Nicotine(DB00184)|Varenicline(DB01273)	ACCATGCGCCGCAGGACGCTC	0.592	Esophageal Squamous(193;529 2900 40232 43193)		NA											36	113					1.08114e-33	1.84681e-33	0.00361	1	0
MEIS2	4212	broad.mit.edu	37	15	37184485	37184485	+	Missense_Mutation	SNP	G	G	T	rs139991974		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:37184485G>T	uc001zjr.2	-	12	2360	c.1323C>A	c.(1321-1323)CAC>CAA	p.H441Q	MEIS2_uc001zjl.2_3'UTR|MEIS2_uc010ucj.1_Missense_Mutation_p.H421Q|MEIS2_uc001zjm.2_3'UTR|MEIS2_uc001zjn.2_3'UTR|MEIS2_uc001zjo.2_3'UTR|MEIS2_uc001zjp.2_3'UTR|MEIS2_uc001zjs.2_Missense_Mutation_p.H434Q|MEIS2_uc001zju.2_3'UTR|MEIS2_uc001zjt.2_Missense_Mutation_p.H434Q|MEIS2_uc001zjj.2_Missense_Mutation_p.H137Q|MEIS2_uc001zjk.2_Missense_Mutation_p.H130Q	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	441					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		GGGGTCCTCCGTGCATCATCA	0.522			NA											135	279					1.00589e-60	1.7611e-60	0.00361	1	0
MEIS2	4212	broad.mit.edu	37	15	37184493	37184493	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:37184493T>G	uc001zjr.2	-	12	2352	c.1315A>C	c.(1315-1317)ATG>CTG	p.M439L	MEIS2_uc001zjl.2_3'UTR|MEIS2_uc010ucj.1_Missense_Mutation_p.M419L|MEIS2_uc001zjm.2_3'UTR|MEIS2_uc001zjn.2_3'UTR|MEIS2_uc001zjo.2_3'UTR|MEIS2_uc001zjp.2_3'UTR|MEIS2_uc001zjs.2_Missense_Mutation_p.M432L|MEIS2_uc001zju.2_3'UTR|MEIS2_uc001zjt.2_Missense_Mutation_p.M432L|MEIS2_uc001zjj.2_Missense_Mutation_p.M135L|MEIS2_uc001zjk.2_Missense_Mutation_p.M128L	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	439					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		CCGTGCATCATCATGGCTGGG	0.512			NA											130	271					0	0	0.00361	0	0
MAP1A	4130	broad.mit.edu	37	15	43821703	43821703	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:43821703C>G	uc001zrt.2	+	4	8499	c.8032C>G	c.(8032-8034)CCA>GCA	p.P2678A		NM_002373	NP_002364	P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2678						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(3)|breast(3)|pancreas(2)|skin(1)	9		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CAAGGCAGGACCAAGTAAGTA	0.552			NA											5	41					0	0	0.001168	0	0
SEMA6D	80031	broad.mit.edu	37	15	48053382	48053382	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:48053382G>A	uc010bek.2	+	5	670	c.310G>A	c.(310-312)GAT>AAT	p.D104N	SEMA6D_uc001zvw.2_Missense_Mutation_p.D104N|SEMA6D_uc001zvx.1_Missense_Mutation_p.D104N|SEMA6D_uc001zvy.2_Missense_Mutation_p.D104N|SEMA6D_uc001zvz.2_Missense_Mutation_p.D104N|SEMA6D_uc001zwa.2_Missense_Mutation_p.D104N|SEMA6D_uc001zwb.2_Missense_Mutation_p.D104N|SEMA6D_uc001zwc.2_Missense_Mutation_p.D104N	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	104	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		AAGACAACAGGATCGAGAAAA	0.403			NA											6	27					0	0	0.001984	0	0
SNUPN	10073	broad.mit.edu	37	15	75902273	75902273	+	Silent	SNP	G	G	A	rs139633458		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:75902273G>A	uc002ban.2	-	4	456	c.366C>T	c.(364-366)GTC>GTT	p.V122V	SNUPN_uc002bao.2_Silent_p.V122V|SNUPN_uc002bap.2_Silent_p.V164V|SNUPN_uc002baq.2_Silent_p.V122V|SNUPN_uc002bar.2_Silent_p.V122V|SNUPN_uc002bas.2_Silent_p.V122V	NM_005701	NP_005692	O95149	SPN1_HUMAN	snurportin 1	122	Necessary for interaction with XPO1.				ncRNA metabolic process|protein import into nucleus|spliceosomal snRNP assembly	cytosol|nuclear pore	protein transporter activity|RNA cap binding			pancreas(1)	1						CAGGGCACACGACCACAATCC	0.502			NA											6	60					0	0	0.001984	0	0
SGK269	79834	broad.mit.edu	37	15	77471865	77471865	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:77471865C>A	uc002bcm.2	-	3	2712	c.2404G>T	c.(2404-2406)GAT>TAT	p.D802Y	SGK269_uc002bcn.2_Missense_Mutation_p.D802Y	NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	802	Pro-rich.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		ACATCAGCATCTGGAGGAATG	0.512			NA											21	127					1.10923e-09	1.50941e-09	0.00278	1	0
ADAMTS7	11173	broad.mit.edu	37	15	79051780	79051780	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:79051780G>C	uc002bej.3	-	24	5255	c.5044C>G	c.(5044-5046)CGG>GGG	p.R1682G		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1682					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						CGGGCAACCCGCTGATGGCCT	0.731			NA											4	14					0	0	0.009096	0	0
RHCG	51458	broad.mit.edu	37	15	90019991	90019991	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:90019991A>G	uc002bnz.2	-	9	1330	c.1306T>C	c.(1306-1308)TGG>CGG	p.W436R	RHCG_uc002bny.2_Missense_Mutation_p.W207R|RHCG_uc002boa.2_RNA	NM_016321	NP_057405	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	436	Cytoplasmic (Potential).				amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			kidney(1)	1	Lung NSC(78;0.0237)|all_lung(78;0.0478)					CTCACCTCCCAGTAGACCGCA	0.567			NA											14	67					0	0	0.004007	0	0
ANPEP	290	broad.mit.edu	37	15	90348375	90348375	+	Silent	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:90348375C>G	uc002bop.3	-	4	1123	c.831G>C	c.(829-831)ACG>ACC	p.T277T		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	277	Extracellular.|Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCAGCAAGTACGTGGACATCT	0.567	NSCLC(30;827 977 2459 19669 26125)		NA											28	171					0	0	0.005443	0	0
PKD1	5310	broad.mit.edu	37	16	2159381	2159382	+	Missense_Mutation	DNP	CT	CT	AA			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:2159381_2159382CT>AA	uc002cos.1	-	15	5995_5996	c.5786_5787AG>TT	c.(5785-5787)GAG>GTT	p.E1929V	PKD1_uc002cot.1_Missense_Mutation_p.E1929V	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	1929	Extracellular (Potential).|PKD 15.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CGGGGAGCACCTCGGGGTTGGC	0.698			NA											8	29					0	0	0.004672	0	0
PKD1	5310	broad.mit.edu	37	16	2164306	2164306	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:2164306C>A	uc002cos.1	-	11	2927	c.2718G>T	c.(2716-2718)GAG>GAT	p.E906D	PKD1_uc002cot.1_Missense_Mutation_p.E906D	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	906	Extracellular (Potential).|PKD 3.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CCACCACGTGCTCCCCCTCAC	0.687			NA											9	35					0.000673444	0.000734904	0.008291	1	0
TRAF7	84231	broad.mit.edu	37	16	2225515	2225515	+	Silent	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:2225515G>C	uc002cow.2	+	17	1617	c.1518G>C	c.(1516-1518)GTG>GTC	p.V506V		NM_032271	NP_115647	Q6Q0C0	TRAF7_HUMAN	TNF receptor-associated factor 7	506	WD 3.				activation of MAPKKK activity|apoptosis|regulation of apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic membrane-bounded vesicle|ubiquitin ligase complex	identical protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						GGGACATCGTGGGCACTGAGC	0.627			NA											15	128					0	0	0.004007	0	0
RRN3	54700	broad.mit.edu	37	16	15155638	15155638	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:15155638G>A	uc002dde.2	-	18	1987	c.1919C>T	c.(1918-1920)TCC>TTC	p.S640F	PDXDC1_uc002ddc.2_Intron|RRN3_uc010uzp.1_Missense_Mutation_p.S508F|RRN3_uc010uzq.1_Missense_Mutation_p.S610F	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	RRN3 RNA polymerase I transcription factor	640	Interaction with EIF3L.|Interaction with TWISTNB.				regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm				ovary(1)	1						CACGGGTGGGGAGCCCACACT	0.517			NA											17	86					0	0	0.004007	0	0
KIAA0430	9665	broad.mit.edu	37	16	15696062	15696062	+	Splice_Site	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:15696062T>C	uc002ddr.2	-	23	4607	c.4414_splice	c.e23-1	p.V1472_splice	KIAA0430_uc002ddq.2_Splice_Site_p.V1306_splice|KIAA0430_uc010uzv.1_Splice_Site_p.V1468_splice|KIAA0430_uc010uzw.1_Splice_Site_p.V1471_splice	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1							peroxisome	nucleotide binding|RNA binding				0						AGTGAAAACCTGGTTAAAAAG	0.418			NA											6	152					0	0	0.001168	0	0
UBFD1	56061	broad.mit.edu	37	16	23573999	23573999	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:23573999A>T	uc002dlv.2	+	5	886	c.684A>T	c.(682-684)AAA>AAT	p.K228N		NM_019116	NP_061989	O14562	UBFD1_HUMAN	ubiquitin-binding protein homolog	228											0				GBM - Glioblastoma multiforme(48;0.0331)		CTGGAGGAAAAGTGAGACTCA	0.517	Melanoma(22;290 1069 22358 48158)		NA											26	58					0	0	0.00632	0	0
PRKCB	5579	broad.mit.edu	37	16	24202456	24202456	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:24202456G>T	uc002dmd.2	+	16	1965	c.1768G>T	c.(1768-1770)GGC>TGC	p.G590C	PRKCB_uc002dme.2_Missense_Mutation_p.G590C	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	590	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	TGGACCTGAAGGCGAACGTGA	0.433			NA											11	92					0.000978159	0.0010633	0.000978	1	0
TUFM	7284	broad.mit.edu	37	16	28856776	28856776	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:28856776C>T	uc002drh.2	-	3	412	c.273G>A	c.(271-273)AAG>AAA	p.K91K	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	88						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						ACTTCTTGAACTTAGCCCCAC	0.547			NA											12	95					0	0	0.001855	0	0
RNF40	9810	broad.mit.edu	37	16	30776581	30776581	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:30776581G>A	uc002dzq.2	+	7	974	c.851G>A	c.(850-852)TGG>TAG	p.W284*	RNF40_uc010caa.2_Nonsense_Mutation_p.W284*|RNF40_uc010cab.2_Nonsense_Mutation_p.W284*|RNF40_uc010vfa.1_Intron|RNF40_uc002dzr.2_Nonsense_Mutation_p.W284*|RNF40_uc010vfb.1_Intron|RNF40_uc010vfc.1_5'Flank	NM_014771	NP_055586	O75150	BRE1B_HUMAN	ring finger protein 40	284	Potential.				histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)	1			Colorectal(24;0.198)			GACTTGCAGTGGGACATCGAG	0.577			NA											4	72					0	0	0.009096	0	0
CYLD	1540	broad.mit.edu	37	16	50816329	50816329	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:50816329G>A	uc002egp.1	+	11	2193	c.1778G>A	c.(1777-1779)GGC>GAC	p.G593D	CYLD_uc002ego.2_Missense_Mutation_p.G590D|CYLD_uc010cbs.1_Missense_Mutation_p.G590D|CYLD_uc002egq.1_Missense_Mutation_p.G590D|CYLD_uc002egr.1_Missense_Mutation_p.G590D|CYLD_uc002egs.1_Missense_Mutation_p.G590D	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	593	Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				AAGAAGAAAGGCATCCAGGGT	0.373			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				20	59					0	0	0.008871	0	0
SALL1	6299	broad.mit.edu	37	16	51174774	51174774	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:51174774G>A	uc010vgs.1	-	2	1390	c.1359C>T	c.(1357-1359)TTC>TTT	p.F453F	SALL1_uc010vgr.1_Silent_p.F356F|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	453	C2H2-type 1.				adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCTTCGCGCAGAACCTGCACT	0.512	GBM(103;1352 1446 1855 4775 8890)		NA											23	161					0	0	0.002299	0	0
CES1	1066	broad.mit.edu	37	16	55862795	55862795	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:55862795C>A	uc002eim.2	-	2	249	c.141G>T	c.(139-141)GTG>GTT	p.V47V	CES1_uc002eil.2_Silent_p.V48V|CES1_uc002ein.2_Silent_p.V47V	NM_001025194	NP_001020365	P23141	EST1_HUMAN	carboxylesterase 1 isoform b precursor	47					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity				0				all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GGAAAATGGCCACAGGCTGTG	0.567	NSCLC(162;1801 2756 42904 52896)		NA											21	79					4.63292e-17	7.13343e-17	0.008871	1	0
HYDIN	54768	broad.mit.edu	37	16	70867931	70867931	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:70867931C>T	uc002ezr.2	-	79	13663	c.13535G>A	c.(13534-13536)CGC>CAC	p.R4512H	HYDIN_uc010cfy.2_RNA	NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	4513										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				GAAGAGGGGGCGCAGGAGCCC	0.557			NA											13	28					0	0	0.00499	0	0
CALB2	794	broad.mit.edu	37	16	71418734	71418734	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr16:71418734G>T	uc002faa.3	+	9	692	c.622G>T	c.(622-624)GAC>TAC	p.D208Y	CALB2_uc010vme.1_RNA|CALB2_uc002fac.3_Intron	NM_001740	NP_001731	P22676	CALB2_HUMAN	calbindin 2 isoform 1	208	5 (Probable).|EF-hand 5.						calcium ion binding				0		Ovarian(137;0.125)				CACATTTTACGACAAGGTAAG	0.493			NA											7	155					0.00307968	0.00329046	0.00308	1	0
ITGAE	3682	broad.mit.edu	37	17	3663536	3663536	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:3663536G>T	uc002fwo.3	-	7	743	c.644C>A	c.(643-645)CCC>CAC	p.P215H		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	215	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AAAGTCTGGGGGATCAATGCT	0.488	NSCLC(182;635 2928 8995 38788)		NA											9	38					7.48243e-07	9.30337e-07	0.006214	1	0
CAMTA2	23125	broad.mit.edu	37	17	4884585	4884585	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:4884585A>G	uc002gah.1	-	8	743	c.635T>C	c.(634-636)ATT>ACT	p.I212T	CAMTA2_uc010cku.1_Missense_Mutation_p.I235T|CAMTA2_uc002gag.1_Missense_Mutation_p.I211T|CAMTA2_uc002gai.1_Missense_Mutation_p.I214T|CAMTA2_uc010ckv.1_5'Flank|CAMTA2_uc010vsu.1_Missense_Mutation_p.I25T	NM_015099	NP_055914	O94983	CMTA2_HUMAN	calmodulin binding transcription activator 2	212					cardiac muscle hypertrophy in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	calmodulin binding|chromatin binding|histone deacetylase binding|transcription factor binding			ovary(1)	1						GGTGTCCAAAATCTGCTGCAC	0.547			NA									OREG0024111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	106					0	0	0.003163	0	0
TP53	7157	broad.mit.edu	37	17	7577108	7577108	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:7577108C>A	uc002gim.2	-	8	1024	c.830G>T	c.(829-831)TGT>TTT	p.C277F	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.C277F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C145F|TP53_uc010cng.1_Missense_Mutation_p.C145F|TP53_uc002gii.1_Missense_Mutation_p.C145F|TP53_uc010cnh.1_Missense_Mutation_p.C277F|TP53_uc010cni.1_Missense_Mutation_p.C277F|TP53_uc002gij.2_Missense_Mutation_p.C277F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	277	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> W (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).|C -> Y (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C277F(20)|p.C277Y(15)|p.0?(7)|p.C277*(6)|p.C277G(4)|p.C277C(4)|p.?(2)|p.C277W(2)|p.C277fs*29(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.V274_P278del(1)|p.C277_P278insXXXXXXX(1)|p.L265_K305del41(1)|p.C275_R283delCACPGRDRR(1)|p.S269fs*21(1)|p.A276_C277delAC(1)|p.F270_D281del12(1)|p.C275fs*67(1)|p.C277R(1)|p.C277S(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TCTCCCAGGACAGGCACAAAC	0.547	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			13	37					5.50884e-06	6.55925e-06	0.001368	1	0
TP53	7157	broad.mit.edu	37	17	7578406	7578406	+	Missense_Mutation	SNP	C	C	T	rs28934578		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:7578406C>T	uc002gim.2	-	5	718	c.524G>A	c.(523-525)CGC>CAC	p.R175H	TP53_uc002gig.1_Missense_Mutation_p.R175H|TP53_uc002gih.2_Missense_Mutation_p.R175H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R43H|TP53_uc010cng.1_Missense_Mutation_p.R43H|TP53_uc002gii.1_Missense_Mutation_p.R43H|TP53_uc010cnh.1_Missense_Mutation_p.R175H|TP53_uc010cni.1_Missense_Mutation_p.R175H|TP53_uc002gij.2_Missense_Mutation_p.R175H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R82H|TP53_uc002gio.2_Missense_Mutation_p.R43H|TP53_uc010vug.1_Missense_Mutation_p.R136H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	175	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in a sporadic cancer; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> C (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R175H(729)|p.R175L(19)|p.R175C(12)|p.R175G(11)|p.0?(7)|p.R175P(5)|p.R175S(5)|p.R43H(5)|p.R82H(5)|p.R175R(4)|p.R174fs*24(3)|p.R175_E180delRCPHHE(3)|p.R175fs*5(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.V173fs*69(1)|p.E171fs*61(1)|p.V173fs*23(1)|p.R174_H178>S(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.R175_H178>X(1)|p.R175fs*6(1)|p.R42fs*24(1)|p.R174_C176delRRC(1)|p.H168fs*69(1)|p.R175fs*72(1)|p.R174fs*70(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.R174fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGGGGGCAGCGCCTCACAAC	0.652	Pancreas(47;798 1329 9957 10801)	R175H(KMS26_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R175H(HCC1395_BREAST)|R175H(KLE_ENDOMETRIUM)|R175H(NCIH196_LUNG)|R175H(AU565_BREAST)|R175H(TYKNU_OVARY)|R175H(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|R175H(SKUT1_SOFT_TISSUE)|R175H(CAL33_UPPER_AERODIGESTIVE_TRACT)|R175H(LS123_LARGE_INTESTINE)|R175H(SKBR3_BREAST)|R175H(RKN_OVARY)|R175H(HUCCT1_BILIARY_TRACT)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			12	62					0	0	0.000978	0	0
WDR16	146845	broad.mit.edu	37	17	9538752	9538752	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:9538752C>T	uc002gly.2	+	11	1420	c.1351C>T	c.(1351-1353)CAG>TAG	p.Q451*	WDR16_uc002glz.2_Nonsense_Mutation_p.Q383*|WDR16_uc010coc.2_Nonsense_Mutation_p.Q461*	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	451	WD 7.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						CTGTCAGACCCAGAAGCTGGA	0.532			NA											7	90					0	0	0.00308	0	0
MYH4	4622	broad.mit.edu	37	17	10358324	10358324	+	Missense_Mutation	SNP	G	G	A	rs143572602	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:10358324G>A	uc002gmn.2	-	21	2480	c.2369C>T	c.(2368-2370)ACG>ATG	p.T790M	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	790	IQ.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTGAGTGCGCGTGATGAGTTG	0.458			NA											6	77					0	0	0.001168	0	0
MYH3	4621	broad.mit.edu	37	17	10533474	10533474	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:10533474T>G	uc002gmq.1	-	37	5574	c.5497A>C	c.(5497-5499)AAG>CAG	p.K1833Q		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1833	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						TCTGTGTTCTTCTTCTGCTCT	0.547			NA											23	376					0	0	0.004656	0	0
DRG2	1819	broad.mit.edu	37	17	18002385	18002385	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:18002385G>A	uc002gsh.1	+	4	425	c.370G>A	c.(370-372)GCC>ACC	p.A124T	DRG2_uc010vxg.1_Missense_Mutation_p.A124T|DRG2_uc002gsi.1_RNA|DRG2_uc002gsj.1_Missense_Mutation_p.A124T	NM_001388	NP_001379	P55039	DRG2_HUMAN	developmentally regulated GTP binding protein 2	124	G.				signal transduction		GTP binding			ovary(1)	1	all_neural(463;0.228)					TGAAGGCGCAGCCCAAGGTGG	0.547			NA											5	83					0	0	0.001168	0	0
ZNF286B	729288	broad.mit.edu	37	17	18566444	18566444	+	Silent	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:18566444T>G	uc010vyd.1	-	5	626	c.375A>C	c.(373-375)TCA>TCC	p.S125S		NM_001145045	NP_001138517	P0CG31	Z286B_HUMAN	zinc finger protein 286B	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AATCTTGCACTGAAGTTGAAT	0.413			NA											4	67					0	0	0.009096	0	0
MAPK7	5598	broad.mit.edu	37	17	19283155	19283155	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:19283155G>A	uc002gvn.2	+	3	679	c.293G>A	c.(292-294)CGG>CAG	p.R98Q	B9D1_uc010cqm.1_5'Flank|B9D1_uc002gvl.3_5'Flank|MAPK7_uc002gvo.2_Intron|MAPK7_uc002gvq.2_Missense_Mutation_p.R98Q|MAPK7_uc002gvp.2_Missense_Mutation_p.R98Q	NM_139033	NP_620602	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7 isoform 1	98	Required for binding to MAP2K5 (By similarity).|Protein kinase.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					AATGCCAAGCGGACCCTCAGG	0.527			NA											9	140					0	0	0.008291	0	0
SARM1	23098	broad.mit.edu	37	17	26715397	26715397	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:26715397G>T	uc010crl.1	+	10	1829	c.1762G>T	c.(1762-1764)GGC>TGC	p.G588C	SARM1_uc010waj.1_RNA|SARM1_uc002hbe.1_Missense_Mutation_p.G132C	NM_015077	NP_055892	Q6SZW1	SARM1_HUMAN	sterile alpha and TIR motif containing 1	588	TIR.				innate immune response	cytoplasm|intrinsic to membrane	binding|transmembrane receptor activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		GCAGCTGCATGGCTTCAGTGT	0.582			NA											14	53					9.05144e-12	1.28783e-11	0.001855	1	0
SUPT6H	6830	broad.mit.edu	37	17	27009765	27009766	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:27009765_27009766GG>TC	uc002hby.2	+	14	1708_1709	c.1618_1619GG>TC	c.(1618-1620)GGG>TCG	p.G540S	SUPT6H_uc010crt.2_Missense_Mutation_p.G540S	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	540					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					CAAAAAGTTTGGGCTTACTCCC	0.53			NA											30	85					0	0	0.004672	0	0
SGCA	6442	broad.mit.edu	37	17	48245884	48245884	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:48245884T>A	uc002iqi.2	+	5	571	c.535T>A	c.(535-537)TTG>ATG	p.L179M	SGCA_uc010wmh.1_Missense_Mutation_p.L77M|SGCA_uc002iqj.2_Missense_Mutation_p.L179M|SGCA_uc010wmi.1_RNA|uc010dbn.1_5'Flank	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	179	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						CACCTCTGCCTTGGACCGTGG	0.622			NA											6	9					0	0	0.001168	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48917075	48917076	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:48917075_48917076CA>AG	uc002isv.3	+	2	1120_1121	c.426_427CA>AG	c.(424-429)CCCAGC>CCAGGC	p.S143G	WFIKKN2_uc010dbu.2_Missense_Mutation_p.S50G	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	143	Kazal-like.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			AGAAGGAGCCCAGCTTTACCTG	0.584			NA											10	42					0	0	0.004672	0	0
SEPT4	5414	broad.mit.edu	37	17	56598633	56598633	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:56598633G>A	uc002iwm.1	-	9	1224	c.1096C>T	c.(1096-1098)CCC>TCC	p.P366S	SEPT4_uc002iwk.1_Missense_Mutation_p.P219S|SEPT4_uc010wnw.1_Missense_Mutation_p.P219S|SEPT4_uc002iwl.1_Missense_Mutation_p.P219S|SEPT4_uc002iwn.1_Missense_Mutation_p.P267S|SEPT4_uc002iwo.1_Missense_Mutation_p.P347S|SEPT4_uc002iwp.1_3'UTR|SEPT4_uc010wnx.1_Missense_Mutation_p.P381S|SEPT4_uc010wny.1_Missense_Mutation_p.P358S|SEPT4_uc010dcy.1_3'UTR	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	366					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ATGCCCCAGGGGTAGAGTCGA	0.587			NA									OREG0024614	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	73					0	0	0.00333	0	0
C17orf47	284083	broad.mit.edu	37	17	56620571	56620571	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:56620571C>A	uc002iwq.1	-	1	1113	c.977G>T	c.(976-978)CGA>CTA	p.R326L	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	326										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTGTTTCCTCGGATTGGGGT	0.542			NA											19	55					1.33834e-09	1.8124e-09	0.007413	1	0
TEX14	56155	broad.mit.edu	37	17	56688569	56688569	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:56688569G>T	uc010dcz.1	-	10	1273	c.1155C>A	c.(1153-1155)ATC>ATA	p.I385I	TEX14_uc002iwr.1_Silent_p.I379I|TEX14_uc002iws.1_Silent_p.I379I|TEX14_uc010dda.1_Silent_p.I159I	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	385	Protein kinase.					cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACCTGGGGAGATGATATGGA	0.527			NA											43	157					3.54561e-26	6.0019e-26	0.009718	1	0
RAD51C	5889	broad.mit.edu	37	17	56774181	56774181	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:56774181C>T	uc002iwu.2	+	3	574	c.532C>T	c.(532-534)CAG>TAG	p.Q178*	RAD51C_uc010woa.1_Nonsense_Mutation_p.Q178*|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_Intron|RAD51C_uc002iww.2_Intron|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	178					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TGCCTGCATTCAGCACCTTCA	0.388			NA						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				13	112					0	0	0.003163	0	0
PRKCA	5578	broad.mit.edu	37	17	64728940	64728940	+	Silent	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:64728940A>G	uc002jfp.1	+	9	1097	c.1053A>G	c.(1051-1053)GGA>GGG	p.G351G	PRKCA_uc002jfo.1_Silent_p.G222G	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	351	ATP (By similarity).|Protein kinase.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GGAGTTTTGGAAAGGTAAGAG	0.453			NA											40	141					0	0	0.006999	0	0
SDK2	54549	broad.mit.edu	37	17	71394502	71394502	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:71394502G>T	uc010dfm.2	-	23	3160	c.3160C>A	c.(3160-3162)CGC>AGC	p.R1054S	SDK2_uc002jjt.3_Missense_Mutation_p.R213S|SDK2_uc010dfn.2_Missense_Mutation_p.R733S	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1054	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						TCCATGGAGCGGGCATCGGGC	0.642			NA											27	92					1.12875e-08	1.49613e-08	0.00632	1	0
FDXR	2232	broad.mit.edu	37	17	72859251	72859251	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:72859251G>A	uc002jly.2	-	11	1379	c.1292C>T	c.(1291-1293)CCC>CTC	p.P431L	GRIN2C_uc002jlu.1_5'Flank|GRIN2C_uc002jlv.1_5'Flank|FDXR_uc010wri.1_Missense_Mutation_p.P379L|FDXR_uc010wrj.1_Missense_Mutation_p.P429L|FDXR_uc002jlw.2_Missense_Mutation_p.P188L|FDXR_uc002jlx.2_Missense_Mutation_p.P437L|FDXR_uc002jmc.2_Missense_Mutation_p.P403L|FDXR_uc010wrk.1_Missense_Mutation_p.P462L|FDXR_uc010wrl.1_Missense_Mutation_p.P474L|FDXR_uc002jma.2_Missense_Mutation_p.P432L|FDXR_uc010wrm.1_Missense_Mutation_p.P391L|FDXR_uc002jlz.2_Missense_Mutation_p.P423L|FDXR_uc002jmb.2_RNA	NM_024417	NP_077728	P22570	ADRO_HUMAN	ferredoxin reductase isoform 1 precursor	431					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding				0	all_lung(278;0.172)|Lung NSC(278;0.207)					GGGGCCAGAGGGGAGCAACCC	0.647			NA											7	25					0	0	0.001984	0	0
FBF1	85302	broad.mit.edu	37	17	73910944	73910944	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:73910944C>A	uc002jqc.2	-	24	2927	c.2653G>T	c.(2653-2655)GAG>TAG	p.E885*	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Nonsense_Mutation_p.E876*|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_Nonsense_Mutation_p.E196*	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	885											0						TCCGCCCACTCGGCAGCCAGG	0.687			NA											4	24					0.00024832	0.000275802	0.009096	1	0
SEC14L1	6397	broad.mit.edu	37	17	75208256	75208256	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:75208256G>T	uc002jto.2	+	15	2103	c.1836G>T	c.(1834-1836)CTG>CTT	p.L612L	SEC14L1_uc010dhc.2_Silent_p.L612L|SEC14L1_uc010wth.1_Silent_p.L612L|SEC14L1_uc002jtm.2_Silent_p.L612L|SEC14L1_uc010wti.1_Silent_p.L578L|SEC14L1_uc010wtj.1_Missense_Mutation_p.D101Y|SEC14L1_uc002jtr.2_Silent_p.L6L	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	612	GOLD.				transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						AGTCGCCTCTGATCTGCAAAG	0.552			NA											64	192					4.83677e-39	8.33824e-39	0.00361	1	0
NARF	26502	broad.mit.edu	37	17	80445829	80445829	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr17:80445829C>A	uc002kfg.3	+	11	1307	c.1167C>A	c.(1165-1167)GAC>GAA	p.D389E	NARF_uc002kff.3_Missense_Mutation_p.D330E|NARF_uc010dit.2_Missense_Mutation_p.D435E|NARF_uc002kfj.3_Missense_Mutation_p.D341E|NARF_uc002kfi.3_RNA|NARF_uc002kfh.3_Missense_Mutation_p.D435E|NARF_uc002kfk.2_RNA	NM_012336	NP_036468	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor isoform a	389						lamin filament	lamin binding			skin(1)	1	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			AGACTCCAGACGGACATGCGG	0.453			NA											5	93					0.00116845	0.00125798	0.001168	1	0
ZNF271	10778	broad.mit.edu	37	18	32887072	32887072	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr18:32887072G>C	uc002kyq.3	+	3	1476	c.484G>C	c.(484-486)GAG>CAG	p.E162Q	ZNF271_uc002kyp.3_Missense_Mutation_p.E162Q|ZNF271_uc002kyr.3_Missense_Mutation_p.E162Q	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						ATCCACACTGGAGAGAAACCT	0.398			NA											16	104					0	0	0.00499	0	0
FHOD3	80206	broad.mit.edu	37	18	34298456	34298456	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr18:34298456G>T	uc002kzt.1	+	15	2716	c.2619G>T	c.(2617-2619)CAG>CAT	p.Q873H	FHOD3_uc002kzs.1_Missense_Mutation_p.Q890H|FHOD3_uc010dmz.1_Missense_Mutation_p.Q605H|FHOD3_uc010dna.1_Missense_Mutation_p.Q193H	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	873					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				ACGCTCCTCAGGGCTTAGGGT	0.567			NA											15	60					2.61681e-11	3.67662e-11	0.00245	1	0
FHOD3	80206	broad.mit.edu	37	18	34324019	34324019	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr18:34324019C>A	uc002kzt.1	+	19	3425	c.3328C>A	c.(3328-3330)CTC>ATC	p.L1110I	FHOD3_uc002kzs.1_Missense_Mutation_p.L1127I|FHOD3_uc010dmz.1_Missense_Mutation_p.L842I|FHOD3_uc010dnb.1_Missense_Mutation_p.L106I	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1110	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				GTTAAGCTACCTCGAGAAGGT	0.453			NA											54	115					3.76997e-23	6.21326e-23	0.00361	1	0
RNF152	220441	broad.mit.edu	37	18	59483224	59483224	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr18:59483224C>T	uc002lih.1	-	2	885	c.473G>A	c.(472-474)CGG>CAG	p.R158Q		NM_173557	NP_775828	Q8N8N0	RN152_HUMAN	ring finger protein 152	158					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)	1		Colorectal(73;0.186)				CACCACGCCCCGCCTGTCCTG	0.622			NA											26	47					0	0	0.00632	0	0
SGTA	6449	broad.mit.edu	37	19	2762622	2762622	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:2762622T>C	uc002lwi.1	-	7	665	c.518A>G	c.(517-519)AAC>AGC	p.N173S		NM_003021	NP_003012	O43765	SGTA_HUMAN	small glutamine-rich tetratricopeptide	173	TPR 3.				interspecies interaction between organisms	cytoplasm	protein binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGTGCTTGTTGAGGCTGGA	0.627			NA											24	181					0	0	0.00333	0	0
ZNF556	80032	broad.mit.edu	37	19	2877918	2877918	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:2877918G>A	uc002lwp.1	+	4	1049	c.962G>A	c.(961-963)GGG>GAG	p.G321E	ZNF556_uc002lwq.2_Missense_Mutation_p.G320E	NM_024967	NP_079243	Q9HAH1	ZN556_HUMAN	zinc finger protein 556	321	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAAATGCGGGAAAGCATTC	0.522			NA											16	55					0	0	0.003163	0	0
ZNF77	58492	broad.mit.edu	37	19	2934603	2934603	+	Silent	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:2934603G>C	uc002lws.3	-	4	653	c.522C>G	c.(520-522)CTC>CTG	p.L174L		NM_021217	NP_067040	Q15935	ZNF77_HUMAN	zinc finger protein 77	174					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		TTTGGCAGGAGAGGCAGCTGC	0.517			NA											6	208					0	0	0.001984	0	0
RANBP3	8498	broad.mit.edu	37	19	5918634	5918634	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:5918634C>T	uc002mdw.2	-	15	1573	c.1346G>A	c.(1345-1347)GGG>GAG	p.G449E	RANBP3_uc002mdv.2_Missense_Mutation_p.G168E|RANBP3_uc002mdx.2_Missense_Mutation_p.G444E|RANBP3_uc002mdy.2_Missense_Mutation_p.G381E|RANBP3_uc002mdz.2_Missense_Mutation_p.G376E|RANBP3_uc010duq.2_Missense_Mutation_p.G354E|RANBP3_uc002mea.2_Missense_Mutation_p.G316E|RANBP3_uc010xix.1_Missense_Mutation_p.G321E	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	449	RanBD1.				intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						TCGCAGGCTCCCCTGGGTCCG	0.607			NA											13	102					0	0	0.001368	0	0
VAV1	7409	broad.mit.edu	37	19	6825072	6825072	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:6825072G>C	uc002mfu.1	+	7	760	c.663G>C	c.(661-663)TTG>TTC	p.L221F	VAV1_uc010xjh.1_Missense_Mutation_p.L189F|VAV1_uc010dva.1_Missense_Mutation_p.L221F|VAV1_uc002mfv.1_Missense_Mutation_p.L166F	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	221	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						AGCATTTCTTGAAGCCCCTGC	0.433			NA											50	160					0	0	0.00361	0	0
LASS4	79603	broad.mit.edu	37	19	8320764	8320764	+	Splice_Site	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:8320764G>A	uc002mjg.2	+	6	788	c.468_splice	c.e6+1	p.H156_splice	LASS4_uc002mjh.2_Splice_Site_p.H105_splice|LASS4_uc002mji.2_Splice_Site|LASS4_uc010dvz.2_Splice_Site_p.H156_splice	NM_024552	NP_078828	Q9HA82	CERS4_HUMAN	LAG1 homolog, ceramide synthase 4							endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity			ovary(1)	1						CCTGTACCACGTGAGTATACC	0.587			NA											4	72					0	0	0.009096	0	0
MUC16	94025	broad.mit.edu	37	19	9047244	9047244	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:9047244G>T	uc002mkp.2	-	5	34591	c.34387C>A	c.(34387-34389)CTG>ATG	p.L11463M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11465	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGATGACCAGTGAGGTCAGC	0.493			NA											59	162					1.16596e-39	2.02243e-39	0.00361	1	0
MUC16	94025	broad.mit.edu	37	19	9091786	9091786	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:9091786G>T	uc002mkp.2	-	1	233	c.29C>A	c.(28-30)TCA>TAA	p.S10*		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10	Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGAGAAGATGACCCAGGAAG	0.547			NA											4	41					1.23904e-05	1.45374e-05	0.000602	1	0
FARSA	2193	broad.mit.edu	37	19	13041475	13041475	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:13041475C>A	uc002mvs.2	-	2	284	c.236G>T	c.(235-237)CGT>CTT	p.R79L	FARSA_uc002mvt.2_RNA|FARSA_uc010xmv.1_Missense_Mutation_p.R79L|FARSA_uc010dyy.1_Intron	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	79					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	TCGAAACACACGGGCCTCATG	0.612			NA											26	44					4.47668e-21	7.12718e-21	0.003954	1	0
CPAMD8	27151	broad.mit.edu	37	19	17057956	17057956	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:17057956C>A	uc002nfb.2	-	21	2763	c.2731G>T	c.(2731-2733)GTG>TTG	p.V911L		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	864						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						CCGGGGGCCACACACATCTTC	0.587			NA											41	153					1.15505e-17	1.7932e-17	0.009718	1	0
CILP2	148113	broad.mit.edu	37	19	19654969	19654969	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:19654969C>T	uc002nmv.3	+	8	1700	c.1615C>T	c.(1615-1617)CCT>TCT	p.P539S	CILP2_uc002nmw.3_Missense_Mutation_p.P545S	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	539						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						CCGGGTCTTGCCTTTTGATCC	0.602			NA											18	62					0	0	0.006122	0	0
LOC284441	284441	broad.mit.edu	37	19	20369153	20369153	+	Translation_Start_Site	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:20369153G>T	uc002nov.2	+	1	697	c.-54G>T	c.(-56--52)TAGGG>TATGG			NR_003128				SubName: Full=cDNA FLJ51655, highly similar to Actin-like protein 2;												0						taactcgctagggtacaacaA	0.169			NA											6	63					0.00116845	0.00125798	0.001168	1	0
ZNF208	7757	broad.mit.edu	37	19	22154156	22154156	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:22154156C>A	uc002nqp.2	-	6	3445	c.3296G>T	c.(3295-3297)TGT>TTT	p.C1099F	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTCTTCACATTTGTAGGG	0.388			NA											5	88					1.23904e-05	1.45374e-05	0.000602	1	0
ZNF208	7757	broad.mit.edu	37	19	22155846	22155846	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:22155846G>T	uc002nqp.2	-	5	1839	c.1690C>A	c.(1690-1692)CCC>ACC	p.P564T	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				CATTTGTAGGGCTTCTCTCCA	0.383			NA											11	112					0.000219431	0.000245658	0.00245	1	0
RYR1	6261	broad.mit.edu	37	19	38948237	38948237	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:38948237T>A	uc002oit.2	+	17	2022	c.1892T>A	c.(1891-1893)CTG>CAG	p.L631Q	RYR1_uc002oiu.2_Missense_Mutation_p.L631Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	631	Cytoplasmic.|B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGTGAGCTTCTGCTGCAGACA	0.522			NA											54	116					0	0	0.00361	0	0
RYR1	6261	broad.mit.edu	37	19	38991553	38991553	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:38991553G>C	uc002oit.2	+	47	7667	c.7537G>C	c.(7537-7539)GAG>CAG	p.E2513Q	RYR1_uc002oiu.2_Missense_Mutation_p.E2513Q|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2513	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GTATGGCATCGAGAACCAGGA	0.632			NA											14	33					0	0	0.001855	0	0
ZNF180	7733	broad.mit.edu	37	19	44981270	44981270	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:44981270C>G	uc002ozf.3	-	5	1710	c.1428G>C	c.(1426-1428)CAG>CAC	p.Q476H	ZNF180_uc002ozh.3_Missense_Mutation_p.Q133H|ZNF180_uc002ozi.3_Missense_Mutation_p.Q449H|ZNF180_uc002ozg.3_Missense_Mutation_p.Q475H|ZNF180_uc010ejm.2_Missense_Mutation_p.Q451H	NM_013256	NP_037388	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	476	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Prostate(69;0.0435)				GTTTATAGCTCTGGATAAATG	0.363	Esophageal Squamous(180;1353 2003 32862 46574 49854)		NA											9	110					0	0	0.004482	0	0
STRN4	29888	broad.mit.edu	37	19	47223906	47223906	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:47223906G>T	uc002pfl.2	-	17	2248	c.2215C>A	c.(2215-2217)CTC>ATC	p.L739I	STRN4_uc002pfm.2_Missense_Mutation_p.L746I|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	739	WD 7.					cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		CTGGCAATGAGGGCCTTGCTG	0.667			NA											4	46					0.00116845	0.00125798	0.001168	1	0
SULT2B1	6820	broad.mit.edu	37	19	49100065	49100065	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:49100065T>G	uc002pjl.2	+	6	796	c.715T>G	c.(715-717)TCC>GCC	p.S239A	SULT2B1_uc002pjm.2_Missense_Mutation_p.S224A	NM_177973	NP_814444	O00204	ST2B1_HUMAN	sulfotransferase family, cytosolic, 2B, member 1	239	PAPS.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	alcohol sulfotransferase activity|protein binding|steroid sulfotransferase activity			skin(1)	1		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000115)|all cancers(93;0.000147)|GBM - Glioblastoma multiforme(486;0.00707)|Epithelial(262;0.0178)		GGCACTGGGCTCCGTCGTGGC	0.667			NA											5	29					0	0	0.000602	0	0
FTL	2512	broad.mit.edu	37	19	49469978	49469978	+	Missense_Mutation	SNP	C	C	G	rs1803580		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:49469978C>G	uc002plo.2	+	4	713	c.514C>G	c.(514-516)CTC>GTC	p.L172V	FTL_uc002pln.1_3'UTR	NM_000146	NP_000137	P02792	FRIL_HUMAN	ferritin, light polypeptide	172					cell death|cellular iron ion homeostasis|cellular membrane organization|iron ion transport|post-Golgi vesicle-mediated transport	cytosol|intracellular ferritin complex	ferric iron binding|identical protein binding|oxidoreductase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000152)|all cancers(93;0.000435)|GBM - Glioblastoma multiforme(486;0.0171)|Epithelial(262;0.0267)	Iron Dextran(DB00893)	AAGGCTCACTCTCAAGCACGA	0.567			NA											4	107					0	0	0.009096	0	0
GPR32	2854	broad.mit.edu	37	19	51274893	51274893	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:51274893T>C	uc010ycf.1	+	1	1036	c.1036T>C	c.(1036-1038)TCA>CCA	p.S346P		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	346	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGAGTTTCTGTCATCCTGTCC	0.537	Esophageal Squamous(113;152 1581 5732 15840 44398)		NA											13	113					0	0	0.001855	0	0
ZNF578	147660	broad.mit.edu	37	19	53014138	53014138	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:53014138C>G	uc002pzp.3	+	6	748	c.504C>G	c.(502-504)CAC>CAG	p.H168Q		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	84	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		CTGAACTCCACATATTTCAGC	0.413			NA											10	227					0	0	0.006214	0	0
ZNF347	84671	broad.mit.edu	37	19	53643854	53643854	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:53643854C>G	uc002qbb.1	-	5	2296	c.2227G>C	c.(2227-2229)GGG>CGG	p.G743R	ZNF347_uc010eql.1_Missense_Mutation_p.G744R|ZNF347_uc002qbc.1_Missense_Mutation_p.G744R	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	743	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		AAGACCTTCCCACACTCATTG	0.433	Melanoma(64;205 1597 17324 45721)		NA											40	158					0	0	0.007835	0	0
ZNF665	79788	broad.mit.edu	37	19	53668345	53668345	+	Silent	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:53668345G>C	uc010eqm.1	-	4	1498	c.1398C>G	c.(1396-1398)GTC>GTG	p.V466V		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	401	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TTTGTGTGAAGACCTTACCGC	0.428			NA											5	100					0	0	0.000602	0	0
LILRB4	11006	broad.mit.edu	37	19	55177363	55177363	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:55177363G>T	uc002qgp.2	+	7	1217	c.855G>T	c.(853-855)CAG>CAT	p.Q285H	LILRB4_uc002qgq.2_Missense_Mutation_p.Q285H|LILRB4_uc002qgr.2_Missense_Mutation_p.Q326H|LILRB4_uc010ert.2_Missense_Mutation_p.Q326H|LILRB4_uc010eru.2_Missense_Mutation_p.Q314H	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	285	Cytoplasmic (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		ACTGGCGTCAGGGAAAACACA	0.473			NA											5	64					4.096e-09	5.50706e-09	0.001168	1	0
LILRB4	11006	broad.mit.edu	37	19	55179179	55179179	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:55179179C>T	uc002qgp.2	+	11	1497	c.1135C>T	c.(1135-1137)CTG>TTG	p.L379L	LILRB4_uc002qgq.2_Silent_p.L378L|LILRB4_uc002qgr.2_Silent_p.L421L|LILRB4_uc010ert.2_Silent_p.L420L|LILRB4_uc010eru.2_Silent_p.L409L	NM_006847	NP_006838	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor,	379	Cytoplasmic (Potential).					integral to membrane|plasma membrane	antigen binding|receptor activity			ovary(3)	3				GBM - Glioblastoma multiforme(193;0.035)		TCCCTCCCCACTGTCTGGGGA	0.582			NA											25	41					0	0	0.003954	0	0
FCAR	2204	broad.mit.edu	37	19	55401199	55401199	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:55401199C>T	uc002qhr.1	+	5	1031	c.834C>T	c.(832-834)ACC>ACT	p.T278T	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Silent_p.T229T|FCAR_uc010esi.1_Silent_p.T155T|FCAR_uc002qhu.1_Silent_p.T182T|FCAR_uc002qhv.1_Silent_p.T256T|FCAR_uc002qhw.1_Silent_p.T266T|FCAR_uc002qhx.1_Silent_p.T170T|FCAR_uc002qhy.1_Silent_p.T244T|FCAR_uc002qhz.1_3'UTR|FCAR_uc002qia.1_Silent_p.T169T	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	278	Cytoplasmic (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CAGGATTGACCTTTGCACGAA	0.527			NA											13	125					0	0	0.001368	0	0
NLRP5	126206	broad.mit.edu	37	19	56538820	56538820	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:56538820C>A	uc002qmj.2	+	7	1221	c.1221C>A	c.(1219-1221)GTC>GTA	p.V407V	NLRP5_uc002qmi.2_Silent_p.V388V	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	407	NACHT.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TCCTGATCGTCACCGTCAGAG	0.547			NA											9	24					5.4927e-09	7.3323e-09	0.004482	1	0
USP29	57663	broad.mit.edu	37	19	57641161	57641161	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:57641161C>A	uc002qny.2	+	4	1474	c.1118C>A	c.(1117-1119)GCT>GAT	p.A373D		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	373					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGAATGATGCTCATGAGTTT	0.353			NA											12	77					7.93312e-07	9.77722e-07	0.00245	1	0
USP29	57663	broad.mit.edu	37	19	57641213	57641213	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:57641213A>C	uc002qny.2	+	4	1526	c.1170A>C	c.(1168-1170)AAA>AAC	p.K390N		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	390					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ACATGGAAAAATTAAATGCCA	0.398			NA											17	76					0	0	0.007413	0	0
ZNF17	7565	broad.mit.edu	37	19	57931586	57931586	+	Silent	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:57931586A>T	uc002qoo.1	+	3	957	c.726A>T	c.(724-726)GGA>GGT	p.G242G	ZNF547_uc002qpm.3_Intron|ZNF17_uc002qop.1_Silent_p.G244G	NM_006959	NP_008890	P17021	ZNF17_HUMAN	zinc finger protein 17	242					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		ATCATACTGGAGAAAGGCCTT	0.403	Melanoma(149;1637 1853 29914 42869 44988)		NA											22	44					0	0	0.010504	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58564911	58564911	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:58564911G>T	uc002qrc.1	+	6	966	c.719G>T	c.(718-720)GGT>GTT	p.G240V		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	240					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		AGCCCCAAGGGTCCAAGTGCT	0.602			NA											20	37					2.54575e-18	3.9964e-18	0.010504	1	0
TPO	7173	broad.mit.edu	37	2	1499813	1499813	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:1499813G>T	uc002qww.2	+	12	2150	c.2059G>T	c.(2059-2061)GAG>TAG	p.E687*	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Nonsense_Mutation_p.E630*|TPO_uc002qwr.2_Nonsense_Mutation_p.E687*|TPO_uc002qwx.2_Nonsense_Mutation_p.E630*|TPO_uc010yio.1_Nonsense_Mutation_p.E514*|TPO_uc010yip.1_Nonsense_Mutation_p.E687*|TPO_uc002qwy.1_Nonsense_Mutation_p.E27*|TPO_uc002qwz.2_Intron	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	687	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GCGTGAGCTGGAGAAGCACTC	0.562			NA											11	22					2.68362e-12	3.90724e-12	0.001368	1	0
NBAS	51594	broad.mit.edu	37	2	15417165	15417165	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:15417165C>A	uc002rcc.1	-	43	5225	c.5199G>T	c.(5197-5199)AAG>AAT	p.K1733N	NBAS_uc010exl.1_Missense_Mutation_p.K805N|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1733										ovary(2)|liver(1)|skin(1)	4						CTGGATCAGTCTTCAAAGTCT	0.393			NA											5	72					0.000602214	0.000658452	0.000602	1	0
NBAS	51594	broad.mit.edu	37	2	15567913	15567913	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:15567913T>C	uc002rcc.1	-	22	2371	c.2345A>G	c.(2344-2346)AAC>AGC	p.N782S	NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	782										ovary(2)|liver(1)|skin(1)	4						GGAGTCACCGTTAAAACTCAA	0.393			NA											5	43					0	0	0.000602	0	0
NCOA1	8648	broad.mit.edu	37	2	24933898	24933898	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:24933898G>A	uc002rfk.2	+	12	2775	c.2517G>A	c.(2515-2517)GCG>GCA	p.A839A	NCOA1_uc010eye.2_Silent_p.A839A|NCOA1_uc002rfi.2_Silent_p.A688A|NCOA1_uc002rfj.2_Silent_p.A839A|NCOA1_uc002rfl.2_Silent_p.A839A	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	839	Interaction with CREBBP.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGATGGTGCGGTCACCAGTG	0.522			NA	T	PAX3	alveolar rhadomyosarcoma								22	38					0	0	0.001882	0	0
C2orf70	339778	broad.mit.edu	37	2	26798827	26798827	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:26798827C>A	uc010eyn.2	+	2	132	c.132C>A	c.(130-132)ACC>ACA	p.T44T		NM_001105519	NP_001098989	A6NJV1	CB070_HUMAN	hypothetical protein LOC339778	44										skin(1)	1						ACGGCACCACCACCCTCAAGT	0.617			NA											13	89					4.3838e-07	5.52398e-07	0.001855	1	0
ZNF513	130557	broad.mit.edu	37	2	27600625	27600625	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:27600625G>A	uc002rkk.2	-	4	1613	c.1413C>T	c.(1411-1413)CCC>CCT	p.P471P	ZNF513_uc002rkj.2_Silent_p.P409P	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	471					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACAGCGGAAGGGCTTCTCGC	0.592			NA											69	147					0	0	0.00361	0	0
C2orf16	84226	broad.mit.edu	37	2	27801985	27801985	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:27801985G>A	uc002rkz.3	+	1	2597	c.2546G>A	c.(2545-2547)CGA>CAA	p.R849Q		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	849										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					TGGAGATCACGATCTAGGACA	0.478			NA											5	123					0	0	0.000602	0	0
TRMT61B	55006	broad.mit.edu	37	2	29092772	29092772	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:29092772C>A	uc002rmm.2	-	1	404	c.372G>T	c.(370-372)ATG>ATT	p.M124I	TRMT61B_uc002rmn.2_Missense_Mutation_p.M124I|TRMT61B_uc010ezk.2_RNA	NM_017910	NP_060380	Q9BVS5	TR61B_HUMAN	tRNA methyltransferase 61 homolog B	124							tRNA (adenine-N1-)-methyltransferase activity				0						CCTGCGAGAGCATCGAAGGAT	0.617			NA											24	47					1.64293e-13	2.42343e-13	0.00333	1	0
LTBP1	4052	broad.mit.edu	37	2	33525618	33525618	+	Silent	SNP	G	G	A	rs139837372		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:33525618G>A	uc002ros.2	+	21	3339	c.3339G>A	c.(3337-3339)TCG>TCA	p.S1113S	LTBP1_uc002rot.2_Silent_p.S787S|LTBP1_uc002rou.2_Silent_p.S786S|LTBP1_uc002rov.2_Silent_p.S733S|LTBP1_uc010ymz.1_Silent_p.S786S|LTBP1_uc010yna.1_Silent_p.S733S|LTBP1_uc010ynb.1_Silent_p.S52S	NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	1112	EGF-like 9; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				ACCAGCTGTCGGCAGCTAAAG	0.468			NA											9	61					0	0	0.006214	0	0
TTC7A	57217	broad.mit.edu	37	2	47251456	47251456	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:47251456G>T	uc002rvo.2	+	14	1967	c.1599G>T	c.(1597-1599)CAG>CAT	p.Q533H	TTC7A_uc002rvm.2_Missense_Mutation_p.Q499H|TTC7A_uc002rvn.1_Missense_Mutation_p.Q414H|TTC7A_uc010fbb.2_Missense_Mutation_p.Q533H|TTC7A_uc010fbc.2_Missense_Mutation_p.Q179H|TTC7A_uc002rvp.2_Missense_Mutation_p.Q414H|TTC7A_uc002rvq.2_Missense_Mutation_p.Q273H|TTC7A_uc002rvr.2_Translation_Start_Site	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	533	TPR 5.						binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			GTGACCCCCAGGTCATCCTCT	0.642			NA											13	26					7.93312e-07	9.77722e-07	0.00245	1	0
STARD7	56910	broad.mit.edu	37	2	96860740	96860740	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:96860740C>G	uc002svm.3	-	3	906	c.505G>C	c.(505-507)GGA>CGA	p.G169R	STARD7_uc002svl.2_5'UTR	NM_020151	NP_064536	Q9NQZ5	STAR7_HUMAN	START domain containing 7 precursor	169	START.					mitochondrion					0						GTGTAGGTTCCAAAAACTAGA	0.423			NA											7	14					0	0	0.00308	0	0
AFF3	3899	broad.mit.edu	37	2	100623335	100623335	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:100623335T>G	uc002tag.2	-	6	868	c.632A>C	c.(631-633)CAC>CCC	p.H211P	AFF3_uc002taf.2_Missense_Mutation_p.H236P|AFF3_uc010fiq.1_Missense_Mutation_p.H211P|AFF3_uc010yvr.1_Missense_Mutation_p.H365P|AFF3_uc002tah.1_Missense_Mutation_p.H236P|AFF3_uc010fir.1_Missense_Mutation_p.H288P|AFF3_uc002tai.2_Missense_Mutation_p.H133P	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	211					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						CTGAACACAGTGTCCGCTGCT	0.597			NA											5	132					0	0	0.001168	0	0
NPAS2	4862	broad.mit.edu	37	2	101604708	101604708	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:101604708G>T	uc002tap.1	+	17	2083	c.1797G>T	c.(1795-1797)CTG>CTT	p.L599L	NPAS2_uc010yvt.1_Silent_p.L664L|NPAS2_uc010fit.1_Intron	NM_002518	NP_002509	Q99743	NPAS2_HUMAN	neuronal PAS domain protein 2	599					central nervous system development|positive regulation of transcription from RNA polymerase II promoter|rhythmic process	transcription factor complex	DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(3)|upper_aerodigestive_tract(1)	4						GCCAGCACCTGCTCAGAGAAT	0.567			NA											4	108					0.00024832	0.000275802	0.009096	1	0
GPR45	11250	broad.mit.edu	37	2	105859317	105859317	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:105859317C>A	uc002tco.1	+	1	1118	c.1002C>A	c.(1000-1002)GCC>GCA	p.A334A		NM_007227	NP_009158	Q9Y5Y3	GPR45_HUMAN	G protein-coupled receptor 45	334	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3						TCCGCGAGGCCTGCATAGAGT	0.542			NA											13	115					0.00010058	0.000113506	0.001368	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107460416	107460416	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:107460416C>A	uc002tdq.2	-	2	137	c.18G>T	c.(16-18)AAG>AAT	p.K6N	ST6GAL2_uc002tdr.2_Missense_Mutation_p.K6N|ST6GAL2_uc002tds.3_Missense_Mutation_p.K6N	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	6	Cytoplasmic (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GTCTCCATTGCTTCAAGTGTG	0.493			NA											30	52					5.77227e-19	9.08688e-19	0.008361	1	0
RGPD4	285190	broad.mit.edu	37	2	108489238	108489238	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:108489238C>G	uc010ywk.1	+	20	4860	c.4778C>G	c.(4777-4779)TCT>TGT	p.S1593C	RGPD4_uc002tdu.2_Missense_Mutation_p.S780C|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1593					intracellular transport		binding			skin(2)	2						CAGAGTGGATCTGAAAGCAAA	0.383			NA											16	492					0	0	0.006122	0	0
IL1F7	27178	broad.mit.edu	37	2	113671403	113671403	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:113671403C>A	uc002tij.2	+	2	159	c.117C>A	c.(115-117)AGC>AGA	p.S39R	IL1F7_uc002tik.2_Intron|IL1F7_uc002til.2_Missense_Mutation_p.S39R|IL1F7_uc002tim.2_Intron|IL1F7_uc002tin.2_5'Flank	NM_014439	NP_055254	Q9NZH6	IL37_HUMAN	interleukin 1 family, member 7 isoform 1	39					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding				0						CAGGCCCAAGCCTCCCCACCA	0.567			NA											5	47					0.000602214	0.000658452	0.000602	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125521656	125521656	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:125521656C>A	uc002tno.2	+	16	2826	c.2462C>A	c.(2461-2463)ACC>AAC	p.T821N	CNTNAP5_uc010flu.2_Missense_Mutation_p.T822N	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	821	Laminin G-like 3.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTTTTTAAAACCACAGCATTA	0.398			NA											6	179					5.9392e-07	7.45051e-07	0.001168	1	0
TUBA3D	113457	broad.mit.edu	37	2	132235910	132235910	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:132235910C>A	uc002tsu.3	+	2	284	c.177C>A	c.(175-177)GGC>GGA	p.G59G		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	59					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		CTGGAGCTGGCAAGCACGTGC	0.562	Ovarian(137;2059 2432 35543 39401)		NA											33	35					9.73076e-26	1.63733e-25	0.006999	1	0
NXPH2	11249	broad.mit.edu	37	2	139429037	139429037	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:139429037G>T	uc002tvi.2	-	2	250	c.250C>A	c.(250-252)CTG>ATG	p.L84M		NM_007226	NP_009157	O95156	NXPH2_HUMAN	neurexophilin 2 precursor	84	II.				neuropeptide signaling pathway	extracellular region				ovary(3)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(221;0.101)		ATGTTGGCCAGCCAATCCCAA	0.493			NA											73	76					3.76054e-38	6.44336e-38	0.00361	1	0
LRP1B	53353	broad.mit.edu	37	2	141274503	141274503	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:141274503C>T	uc002tvj.1	-	50	9076	c.8104G>A	c.(8104-8106)GAT>AAT	p.D2702N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2702	Extracellular (Potential).|LDL-receptor class A 15.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTCTGACCATCGCATATCCAG	0.328	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			6	74					0	0	0.001168	0	0
LRP1B	53353	broad.mit.edu	37	2	141707905	141707905	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:141707905C>G	uc002tvj.1	-	20	4007	c.3035G>C	c.(3034-3036)AGA>ACA	p.R1012T	LRP1B_uc010fnl.1_Missense_Mutation_p.R194T	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1012	Extracellular (Potential).|LDL-receptor class A 7.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTGGAACATCTGAACTGATT	0.488	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			13	61					0	0	0.003163	0	0
TTC21B	79809	broad.mit.edu	37	2	166773863	166773863	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:166773863G>A	uc002udk.2	-	14	1936	c.1803C>T	c.(1801-1803)TCC>TCT	p.S601S		NM_024753	NP_079029	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	601						cilium axoneme|cytoplasm|cytoskeleton	binding			ovary(2)|pancreas(2)|breast(1)	5						TTGATTTTGTGGAAGCTCCAA	0.373			NA											5	127					0	0	0.001168	0	0
SCN9A	6335	broad.mit.edu	37	2	167142874	167142874	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:167142874T>G	uc010fpl.2	-	11	1915	c.1574A>C	c.(1573-1575)CAT>CCT	p.H525P	uc002udp.2_Intron|SCN9A_uc002udr.1_Missense_Mutation_p.H396P|SCN9A_uc002uds.1_Missense_Mutation_p.H396P|SCN9A_uc002udt.1_Missense_Mutation_p.H396P	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	525						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CCTCTTTTCATGTGCTCGCCT	0.438			NA											17	400					0	0	0.006122	0	0
XIRP2	129446	broad.mit.edu	37	2	167760365	167760365	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:167760365A>G	uc002udx.2	+	1	391	c.373A>G	c.(373-375)AAG>GAG	p.K125E	XIRP2_uc010fpn.2_Missense_Mutation_p.K125E|XIRP2_uc010fpo.2_Missense_Mutation_p.K125E|XIRP2_uc010fpp.2_Missense_Mutation_p.K125E	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGAGGCTCCTAAGAGTGGAAA	0.483			NA											10	125					0	0	0.000978	0	0
XIRP2	129446	broad.mit.edu	37	2	168107427	168107427	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:168107427C>A	uc002udx.2	+	8	9543	c.9525C>A	c.(9523-9525)CCC>CCA	p.P3175P	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.P3000P|XIRP2_uc010fpq.2_Silent_p.P2953P|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3000					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CTTCTCCACCCAGGAGTCGCT	0.498			NA											14	99					6.31663e-08	8.19849e-08	0.003163	1	0
DLX1	1745	broad.mit.edu	37	2	172952820	172952820	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:172952820C>T	uc002uhl.2	+	3	801	c.603C>T	c.(601-603)AAC>AAT	p.N201N	DLX1_uc002uhm.2_3'UTR	NM_178120	NP_835221	P56177	DLX1_HUMAN	distal-less homeobox 1 isoform 1	201						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			CGTTGGCCAACGGTCGGGCCC	0.612			NA											29	147					0	0	0.00632	0	0
TTN	7273	broad.mit.edu	37	2	179441915	179441915	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:179441915G>A	uc010zfg.1	-	273	61667	c.61443C>T	c.(61441-61443)ATC>ATT	p.I20481I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.I14176I|TTN_uc010zfi.1_Silent_p.I14109I|TTN_uc010zfj.1_Silent_p.I13984I|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21408							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAACATTACTGATTTCAACAG	0.443			NA											8	46					0	0	0.00308	0	0
TTN	7273	broad.mit.edu	37	2	179567252	179567252	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:179567252T>C	uc010zfg.1	-	104	26854	c.26630A>G	c.(26629-26631)CAG>CGG	p.Q8877R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.Q5538R|TTN_uc010fre.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	9804							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTGTATTTCTGGCTCTCTGT	0.453			NA											13	360					0	0	0.001368	0	0
COL5A2	1290	broad.mit.edu	37	2	189910587	189910587	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:189910587C>A	uc002uqk.2	-	46	3523	c.3248G>T	c.(3247-3249)GGT>GTT	p.G1083V	COL5A2_uc010frx.2_Missense_Mutation_p.G659V	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1083					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCAGGGGCACCCTGAGAGCC	0.483			NA											36	71					6.57855e-14	9.83283e-14	0.009718	1	0
NRP2	8828	broad.mit.edu	37	2	206614460	206614460	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:206614460A>G	uc002vaw.2	+	11	2589	c.1798A>G	c.(1798-1800)ACG>GCG	p.T600A	NRP2_uc002vau.2_Missense_Mutation_p.T600A|NRP2_uc002vav.2_Missense_Mutation_p.T600A|NRP2_uc002vax.2_Missense_Mutation_p.T600A|NRP2_uc002vay.2_Missense_Mutation_p.T600A	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	600	Extracellular (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						CTCCAAGCCCACGGTAGAGAC	0.547			NA											12	80					0	0	0.001855	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171353	207171353	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:207171353T>G	uc002vbp.2	+	5	2351	c.2101T>G	c.(2101-2103)TCT>GCT	p.S701A		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	701							nucleic acid binding|zinc ion binding			ovary(3)	3						GAGTGTTCAGTCTAGCCGTTC	0.423			NA											5	68					0	0	0.000602	0	0
CPS1	1373	broad.mit.edu	37	2	211456608	211456608	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:211456608C>A	uc002vee.3	+	10	1133	c.1001C>A	c.(1000-1002)GCT>GAT	p.A334D	CPS1_uc010fur.2_Missense_Mutation_p.A340D|CPS1_uc010fus.2_5'Flank	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	334	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCATTACTGCTCAGAATCAT	0.413			NA											10	91					2.17888e-05	2.53002e-05	0.006214	1	0
ACCN4	55515	broad.mit.edu	37	2	220397160	220397160	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:220397160G>A	uc002vma.2	+	4	1374	c.1360G>A	c.(1360-1362)GTG>ATG	p.V454M	ACCN4_uc010fwi.1_Missense_Mutation_p.V454M|ACCN4_uc010fwj.1_Missense_Mutation_p.V454M|ACCN4_uc002vly.1_3'UTR|ACCN4_uc002vlz.2_Missense_Mutation_p.V454M|ACCN4_uc002vmb.2_Missense_Mutation_p.V108M	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	454	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		AAAGGAGGCCGTGCTTCAGCG	0.677			NA											6	50					0	0	0.001984	0	0
DIS3L2	129563	broad.mit.edu	37	2	233103338	233103338	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:233103338G>T	uc010fxz.2	+	11	1576	c.1300G>T	c.(1300-1302)GTC>TTC	p.V434F	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	434							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		GGCTACAAGCGTCTACTTGGT	0.423			NA											20	34					1.87028e-06	2.25075e-06	0.001882	1	0
ALPI	248	broad.mit.edu	37	2	233323382	233323382	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:233323382G>T	uc002vst.3	+	10	1301	c.1224G>T	c.(1222-1224)ACG>ACT	p.T408T	ALPI_uc002vsu.3_Silent_p.T319T	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	408					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		AAGCCTACACGTCCATCCTGT	0.572			NA											19	25					1.87028e-06	2.25075e-06	0.001882	1	0
UGT1A8	54576	broad.mit.edu	37	2	234526902	234526902	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:234526902C>T	uc002vup.2	+	1	612	c.549C>T	c.(547-549)TGC>TGT	p.C183C	UGT1A8_uc010zmv.1_Silent_p.C183C	NM_019076	NP_061949	Q9HAW9	UD18_HUMAN	UDP glycosyltransferase 1 family, polypeptide A8	183					drug metabolic process|fatty acid metabolic process|flavone metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme inhibitor activity|fatty acid binding|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|steroid binding			ovary(2)	2		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;2.56e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000482)|Lung(119;0.00404)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTGCACAGTGCCCTGCTCCTC	0.493			NA											37	353					0	0	0.006999	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581299	234581299	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:234581299C>G	uc002vus.2	+	1	756	c.719C>G	c.(718-720)ACG>AGG	p.T240R	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Missense_Mutation_p.T240R	NM_021027	NP_066307	O60656	UD19_HUMAN	UDP glycosyltransferase 1 family, polypeptide A9	240					drug metabolic process|flavone metabolic process|negative regulation of fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding			ovary(3)|breast(1)|skin(1)	5		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)	Entacapone(DB00494)|Etodolac(DB00749)|Indomethacin(DB00328)|Irinotecan(DB00762)|Mycophenolic acid(DB01024)|Oxyphenonium(DB00219)|Propofol(DB00818)|Sorafenib(DB00398)	ACACCTGTTACGGAGTATGAT	0.428			NA											248	309					0	0	0.00361	0	0
DNAJB3	414061	broad.mit.edu	37	2	234652434	234652434	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:234652434C>A	uc002vuz.2	-	1	228	c.129G>T	c.(127-129)GAG>GAT	p.E43D	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	43	J.				protein folding		heat shock protein binding|unfolded protein binding				0						TGAATCTCCTCTCCGCTTCCT	0.627			NA											24	270					4.06085e-26	6.85345e-26	0.007291	1	0
COL6A3	1293	broad.mit.edu	37	2	238285946	238285946	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr2:238285946T>C	uc002vwl.2	-	7	2824	c.2539A>G	c.(2539-2541)AAT>GAT	p.N847D	COL6A3_uc002vwo.2_Missense_Mutation_p.N641D|COL6A3_uc010znj.1_Missense_Mutation_p.N240D|COL6A3_uc002vwq.2_Missense_Mutation_p.N641D|COL6A3_uc002vwr.2_Missense_Mutation_p.N440D|COL6A3_uc010znk.1_Missense_Mutation_p.N647D	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	847	Nonhelical region.|VWFA 5.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCCACAAGATTGGCTGAGCCG	0.498			NA											53	57					0	0	0.00361	0	0
SIRPA	140885	broad.mit.edu	37	20	1903223	1903223	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:1903223C>T	uc002wfq.2	+	5	1379	c.1019C>T	c.(1018-1020)GCG>GTG	p.A340V	SIRPA_uc010zps.1_Missense_Mutation_p.A320V|SIRPA_uc002wfr.2_Missense_Mutation_p.A340V|SIRPA_uc002wfs.2_Missense_Mutation_p.A340V|SIRPA_uc002wft.2_Missense_Mutation_p.A340V	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	340	Ig-like C1-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		GGGCAGCCAGCGGTCAGCAAA	0.572	GBM(155;1668 1920 5945 42733 48121)		NA											15	41					0	0	0.004007	0	0
SLC4A11	83959	broad.mit.edu	37	20	3215504	3215504	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:3215504G>T	uc002wig.2	-	2	221	c.173C>A	c.(172-174)GCC>GAC	p.A58D	SLC4A11_uc010zqe.1_Missense_Mutation_p.A85D|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Missense_Mutation_p.A42D	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	58	Cytoplasmic (Potential).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CTCCTCTCGGGCTTCGAAGGT	0.542	NSCLC(190;922 2139 10266 10292 38692)		NA											21	46					7.87624e-14	1.17412e-13	0.00278	1	0
RASSF2	9770	broad.mit.edu	37	20	4776594	4776594	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:4776594C>A	uc002wld.2	-	4	208	c.154G>T	c.(154-156)GTG>TTG	p.V52L	RASSF2_uc002wlc.2_5'Flank|RASSF2_uc002wle.2_RNA|RASSF2_uc002wlf.2_Missense_Mutation_p.V52L	NM_170774	NP_739580	P50749	RASF2_HUMAN	Ras association domain family 2	52					cell cycle|signal transduction	nucleus	protein binding			ovary(3)|lung(2)|large_intestine(1)	6						AGCCCCTCCACAATGAACTCG	0.562	Melanoma(158;1891 3343 50738)		NA											17	59					9.7654e-05	0.000110648	0.007413	1	0
PLCB1	23236	broad.mit.edu	37	20	8719992	8719992	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:8719992C>A	uc002wnb.2	+	21	2296	c.2293C>A	c.(2293-2295)CAA>AAA	p.Q765K	PLCB1_uc010zrb.1_Missense_Mutation_p.Q664K|PLCB1_uc002wna.2_Missense_Mutation_p.Q765K|PLCB1_uc002wnc.1_Missense_Mutation_p.Q664K|PLCB1_uc002wnd.1_Missense_Mutation_p.Q342K	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	765					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTTGCCAGTGCAAGCCATTCG	0.393			NA											5	70					0.00116845	0.00125798	0.001168	1	0
PAK7	57144	broad.mit.edu	37	20	9546642	9546642	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:9546642G>T	uc002wnl.2	-	6	1925	c.1380C>A	c.(1378-1380)ACC>ACA	p.T460T	PAK7_uc002wnk.2_Silent_p.T460T|PAK7_uc002wnj.2_Silent_p.T460T|PAK7_uc010gby.1_Silent_p.T460T	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	460	Protein kinase.|ATP (By similarity).						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ATACGATGCCGGTTGAGCCTT	0.532			NA											8	194					7.48243e-07	9.30337e-07	0.006214	1	0
RALGAPA2	57186	broad.mit.edu	37	20	20563737	20563737	+	Silent	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:20563737A>C	uc002wrz.2	-	20	2807	c.2664T>G	c.(2662-2664)CGT>CGG	p.R888R	RALGAPA2_uc010gcx.2_Silent_p.R592R|RALGAPA2_uc010zsg.1_Silent_p.R336R	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	888					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						GTAACCAATGACGGGCATCAG	0.478			NA											6	65					0	0	0.001168	0	0
SEMG1	6406	broad.mit.edu	37	20	43836993	43836993	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:43836993G>A	uc002xni.2	+	2	1112	c.1055G>A	c.(1054-1056)AGT>AAT	p.S352N	SEMG1_uc002xnj.2_Missense_Mutation_p.S292N|SEMG2_uc010ggz.2_Intron|SEMG1_uc002xnh.2_Intron	NM_003007	NP_002998	P04279	SEMG1_HUMAN	semenogelin I preproprotein	352	58 AA repeat 2.				insemination|sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(2)	2		Myeloproliferative disorder(115;0.0122)				CAATCTTCAAGTACGGAAGAA	0.408			NA											6	35					0	0	0.001168	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44506100	44506100	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:44506100C>T	uc002xqd.2	+	2	1106	c.903C>T	c.(901-903)GCC>GCT	p.A301A	ZSWIM3_uc010zxg.1_Silent_p.A295A	NM_080752	NP_542790	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM domain containing 3	301							zinc ion binding			ovary(2)	2		Myeloproliferative disorder(115;0.0122)				TTCCTGCTGCCCGCATCCTCC	0.502			NA											12	77					0	0	0.000978	0	0
TFAP2C	7022	broad.mit.edu	37	20	55208437	55208437	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:55208437G>T	uc002xya.2	+	4	858	c.615G>T	c.(613-615)CTG>CTT	p.L205L	TFAP2C_uc010zzi.1_Silent_p.L36L	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	205					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			AGAACCCTCTGAACCTCCCCT	0.517			NA											11	70					6.40141e-05	7.32707e-05	0.000978	1	0
CDH4	1002	broad.mit.edu	37	20	60499428	60499428	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:60499428C>T	uc002ybn.1	+	11	1679	c.1665C>T	c.(1663-1665)CAC>CAT	p.H555H	CDH4_uc002ybp.1_Silent_p.H481H	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	555	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCTGGCTGCACATCAATGCCA	0.622			NA											6	65					0	0	0.001984	0	0
YTHDF1	54915	broad.mit.edu	37	20	61834123	61834123	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr20:61834123C>G	uc002yeh.2	-	4	1463	c.1169G>C	c.(1168-1170)CGT>CCT	p.R390P	YTHDF1_uc011aaq.1_Missense_Mutation_p.R340P	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	390	YTH.									ovary(2)	2						GATGAACACACGCCCGCTTTT	0.532			NA											51	116					0	0	0.00361	0	0
JAM2	58494	broad.mit.edu	37	21	27071084	27071084	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr21:27071084C>A	uc002ylp.1	+	5	1035	c.490C>A	c.(490-492)CCT>ACT	p.P164T	JAM2_uc011ace.1_Missense_Mutation_p.P164T|JAM2_uc002ylq.1_RNA|JAM2_uc011acf.1_Missense_Mutation_p.P128T|JAM2_uc010glh.1_RNA|JAM2_uc002ylr.1_Missense_Mutation_p.P164T|JAM2_uc010gli.1_Missense_Mutation_p.P164T	NM_021219	NP_067042	P57087	JAM2_HUMAN	junctional adhesion molecule 2 precursor	164	Extracellular (Potential).|Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction					0						GAATCCAGCTCCTGAATACAC	0.463			NA											29	45					1.04121e-07	1.34211e-07	0.005443	1	0
KRTAP6-1	337966	broad.mit.edu	37	21	31986019	31986019	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr21:31986019A>T	uc002yop.2	-	1	205	c.205T>A	c.(205-207)TAC>AAC	p.Y69N	KRTAP20-1_uc011ade.1_5'Flank	NM_181602	NP_853633	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	69						cytosol|intermediate filament					0						CAATAATAGTAGCCAGAGCCA	0.532			NA											24	146					0	0	0.00333	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253732	32253732	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr21:32253732C>A	uc002yov.2	-	1	143	c.112G>T	c.(112-114)GGC>TGC	p.G38C		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	38						keratin filament	structural molecule activity			pancreas(1)	1						CAGATGCCGCCCAGGCAGTCA	0.567			NA											35	60					1.45844e-13	2.16264e-13	0.002836	1	0
TIAM1	7074	broad.mit.edu	37	21	32639219	32639219	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr21:32639219T>G	uc002yow.1	-	5	542	c.70A>C	c.(70-72)AAG>CAG	p.K24Q	TIAM1_uc011adk.1_Missense_Mutation_p.K24Q|TIAM1_uc011adl.1_Missense_Mutation_p.K24Q|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	24				KH -> ND (in Ref. 1; AAA98443).	apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						GAAGTGTGCTTGCGCCCCAGG	0.582			NA											10	55					0	0	0.000978	0	0
GCFC1	94104	broad.mit.edu	37	21	34136681	34136681	+	Silent	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr21:34136681A>C	uc002yqn.2	-	3	817	c.627T>G	c.(625-627)TCT>TCG	p.S209S	GCFC1_uc002yqo.2_RNA|GCFC1_uc002yqp.2_Silent_p.S209S|GCFC1_uc002yqr.2_Silent_p.S209S	NM_016631	NP_057715	Q9Y5B6	GCFC1_HUMAN	GC-rich sequence DNA-binding factor candidate	209						cytosol|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2						CATTCAATGAAGATAAAGCAT	0.358			NA											14	67					0	0	0.003163	0	0
PI4KA	5297	broad.mit.edu	37	22	21174084	21174084	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr22:21174084T>C	uc002zsz.3	-	6	691	c.460A>G	c.(460-462)ATC>GTC	p.I154V	PI4KA_uc010gsq.1_Missense_Mutation_p.I212V	NM_058004	NP_477352	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase type 3 alpha	154					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			lung(2)|upper_aerodigestive_tract(1)|salivary_gland(1)	4	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			TGAGGAGGGATTTTGGGAAAG	0.507	GBM(136;1332 1831 3115 23601 50806)		NA											70	160					0	0	0.00361	0	0
IGLL3	91353	broad.mit.edu	37	22	25715839	25715839	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr22:25715839G>A	uc003abr.2	+	2	561	c.461G>A	c.(460-462)GGA>GAA	p.G154E		NM_001013618	NP_001013640			immunoglobulin lambda-like polypeptide 3												0						TTCTATCTGGGAATCTTGACG	0.582			NA											7	132					0	0	0.00308	0	0
DMC1	11144	broad.mit.edu	37	22	38962738	38962738	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr22:38962738C>T	uc003avz.1	-	4	275	c.100G>A	c.(100-102)GTG>ATG	p.V34M	DMC1_uc011anv.1_Missense_Mutation_p.V34M|DMC1_uc003awa.1_Missense_Mutation_p.V34M	NM_007068	NP_008999	Q14565	DMC1_HUMAN	DMC1 dosage suppressor of mck1 homolog	34					reciprocal meiotic recombination	condensed nuclear chromosome	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding			ovary(1)	1	Melanoma(58;0.0286)					ATGTCAGCCACGTTCTGTAAA	0.428			NA						Homologous_recombination					4	43					0	0	0.009096	0	0
TAB1	10454	broad.mit.edu	37	22	39811578	39811578	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr22:39811578C>G	uc003axt.2	+	3	293	c.244C>G	c.(244-246)CAG>GAG	p.Q82E	TAB1_uc003axr.2_Missense_Mutation_p.Q158E|TAB1_uc011aok.1_5'UTR|TAB1_uc003axu.1_Missense_Mutation_p.Q82E	NM_006116	NP_006107	Q15750	TAB1_HUMAN	mitogen-activated protein kinase kinase kinase 7	82	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)	1						CTTCGTGGCCCAGCGGCTGTC	0.632			NA											25	45					0	0	0.00333	0	0
TEF	7008	broad.mit.edu	37	22	41790242	41790242	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr22:41790242C>G	uc003azy.2	+	3	704	c.618C>G	c.(616-618)CAC>CAG	p.H206Q	TEF_uc003azx.2_Missense_Mutation_p.H176Q|TEF_uc011apa.1_Missense_Mutation_p.H211Q	NM_003216	NP_003207	Q10587	TEF_HUMAN	thyrotrophic embryonic factor isoform 1	206	Pro-rich (proline/acidic region (PAR)).				rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCGGAAGCACAAGTTTGCTG	0.542			NA											14	89					0	0	0.001855	0	0
CHL1	10752	broad.mit.edu	37	3	447225	447226	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:447225_447226GG>TT	uc003bou.2	+	27	3729_3730	c.3458_3459GG>TT	c.(3457-3459)AGG>ATT	p.R1153I	CHL1_uc003bot.2_Missense_Mutation_p.R1169I|CHL1_uc011asi.1_Missense_Mutation_p.R1116I	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1153	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TCCCTTAATAGGGATATGCAGC	0.406			NA											10	58					0	0	0.004672	0	0
TBC1D5	9779	broad.mit.edu	37	3	17208305	17208305	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:17208305C>A	uc003cbf.2	-	21	3713	c.2048G>T	c.(2047-2049)GGC>GTC	p.G683V	TBC1D5_uc010heu.2_Missense_Mutation_p.G270V|TBC1D5_uc010hev.2_Missense_Mutation_p.G705V|TBC1D5_uc003cbe.2_Missense_Mutation_p.G683V	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b	683						intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						TTGGCCTCGGCCCTGGCCCTG	0.522			NA											23	58					1.9806e-07	2.52976e-07	0.002299	1	0
TBC1D5	9779	broad.mit.edu	37	3	17299997	17299997	+	Splice_Site	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:17299997C>A	uc003cbf.2	-	16	2996	c.1331_splice	c.e16+1	p.R444_splice	TBC1D5_uc010heu.2_Splice_Site_p.R31_splice|TBC1D5_uc010hev.2_Splice_Site_p.R444_splice|TBC1D5_uc003cbe.2_Splice_Site_p.R444_splice|TBC1D5_uc010hew.1_Splice_Site_p.R396_splice	NM_014744	NP_055559	Q92609	TBCD5_HUMAN	TBC1 domain family, member 5 isoform b							intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						AGGGGACTTACCGGCTTTTAT	0.333			NA											57	187					6.60958e-23	1.07982e-22	0.00361	1	0
KCNH8	131096	broad.mit.edu	37	3	19575253	19575253	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:19575253T>A	uc003cbk.1	+	16	3181	c.2986T>A	c.(2986-2988)TCC>ACC	p.S996T	KCNH8_uc010hex.1_Missense_Mutation_p.S457T	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	996	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TTATTCACCTTCCCACTACCA	0.478	NSCLC(124;1625 1765 8018 24930 42026)		NA											14	247					0	0	0.00245	0	0
EFHB	151651	broad.mit.edu	37	3	19938246	19938246	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:19938246T>C	uc003cbl.3	-	9	1854	c.1658A>G	c.(1657-1659)CAT>CGT	p.H553R	EFHB_uc003cbm.2_Missense_Mutation_p.H423R	NM_144715	NP_653316	Q8N7U6	EFHB_HUMAN	EF hand domain family, member B	553					signal transduction	proteinaceous extracellular matrix	calcium ion binding				0						CTTCAGGTGATGCCGAACTGC	0.458			NA											21	71					0	0	0.00333	0	0
TMPPE	643853	broad.mit.edu	37	3	33134917	33134917	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:33134917C>T	uc003cfk.2	-	2	962	c.771G>A	c.(769-771)ACG>ACA	p.T257T	GLB1_uc003cfh.1_Intron|GLB1_uc003cfi.1_Intron|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Intron|TMPPE_uc011axl.1_Silent_p.T120T	NM_001039770	NP_001034859	Q6ZT21	TMPPE_HUMAN	transmembrane protein with	257						integral to membrane	metal ion binding				0						GAGCGACAGCCGTCCGCAGGA	0.537			NA											6	122					0	0	0.00308	0	0
ZNF445	353274	broad.mit.edu	37	3	44496938	44496938	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:44496938T>C	uc003cnf.2	-	3	452	c.104A>G	c.(103-105)TAT>TGT	p.Y35C	ZNF445_uc011azv.1_Missense_Mutation_p.Y35C|ZNF445_uc011azw.1_Missense_Mutation_p.Y35C	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	35					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		CACTGGAGTATAGCTTTCATC	0.592			NA											33	96					0	0	0.002836	0	0
PLXNB1	5364	broad.mit.edu	37	3	48459666	48459666	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:48459666C>A	uc003csw.2	-	15	3426	c.3156G>T	c.(3154-3156)GTG>GTT	p.V1052V	PLXNB1_uc003csu.2_Silent_p.V869V|PLXNB1_uc003csx.2_Silent_p.V1052V|PLXNB1_uc010hjx.1_RNA|PLXNB1_uc003csy.1_5'Flank	NM_002673	NP_002664	O43157	PLXB1_HUMAN	plexin B1 precursor	1052	Extracellular (Potential).				axon guidance|cell migration|intracellular signal transduction|regulation of cell shape|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|semaphorin-plexin signaling pathway	extracellular region|integral to plasma membrane|intracellular|semaphorin receptor complex	GTPase activator activity|semaphorin receptor activity|semaphorin receptor binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTCCCGGGTCACACAACGTG	0.622			NA											5	23					1.23904e-05	1.45374e-05	0.000602	1	0
LAMB2	3913	broad.mit.edu	37	3	49161443	49161443	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:49161443C>A	uc003cwe.2	-	24	3814	c.3515G>T	c.(3514-3516)CGC>CTC	p.R1172L		NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	1172	Laminin EGF-like 13.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CTGGTCACAGCGCACACCAGA	0.582			NA											9	47					1.58986e-06	1.92151e-06	0.008291	1	0
VPRBP	9730	broad.mit.edu	37	3	51475837	51475837	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:51475837C>A	uc003dbe.1	-	8	758	c.590G>T	c.(589-591)AGT>ATT	p.S197I	VPRBP_uc003dbg.1_Missense_Mutation_p.S197I	NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	197					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CTTCCGTGGACTGGGACGCTT	0.498			NA											70	228					2.40041e-21	3.85438e-21	0.00361	1	0
ALAS1	211	broad.mit.edu	37	3	52236729	52236729	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:52236729G>T	uc003dcy.1	+	4	743	c.406G>T	c.(406-408)GAA>TAA	p.E136*	ALAS1_uc003dcx.1_Nonsense_Mutation_p.E136*|ALAS1_uc003dcz.1_Nonsense_Mutation_p.E136*|ALAS1_uc011bec.1_Nonsense_Mutation_p.E153*	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	136					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	GGATGTGCAGGAAATGAATGC	0.488			NA											14	47					1.5842e-08	2.09487e-08	0.001855	1	0
ASB14	142686	broad.mit.edu	37	3	57311911	57311911	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:57311911A>T	uc003diq.2	-	9	1565	c.977T>A	c.(976-978)CTC>CAC	p.L326H	ASB14_uc003dip.1_Missense_Mutation_p.L205H	NM_001142733	NP_001136205	A6NK59	ASB14_HUMAN	ankyrin repeat and SOCS box-containing 14	490					intracellular signal transduction						0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		CTTTCCAGAGAGATGTTGCAG	0.383			NA											12	56					0	0	0.000978	0	0
LRIG1	26018	broad.mit.edu	37	3	66502041	66502041	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:66502041C>A	uc003dmx.2	-	3	321	c.307G>T	c.(307-309)GAG>TAG	p.E103*	LRIG1_uc010hnz.2_5'UTR|LRIG1_uc010hoa.2_Nonsense_Mutation_p.E103*	NM_015541	NP_056356	Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like	103	Extracellular (Potential).|LRR 2.					integral to membrane				skin(3)|ovary(2)	5		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		GCTGTCAACTCATTATTATTG	0.438			NA											22	93					0.00188189	0.00202222	0.001882	1	0
FOXP1	27086	broad.mit.edu	37	3	71015118	71015118	+	Silent	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:71015118T>C	uc003dol.2	-	16	2135	c.1812A>G	c.(1810-1812)GAA>GAG	p.E604E	FOXP1_uc003dom.2_Silent_p.E528E|FOXP1_uc003don.2_RNA|FOXP1_uc003doo.2_Silent_p.E603E|FOXP1_uc003dop.2_Silent_p.E604E|FOXP1_uc003doq.1_Intron|FOXP1_uc003doi.2_Silent_p.E504E|FOXP1_uc003doj.2_Silent_p.E504E|FOXP1_uc003dok.2_Silent_p.E417E	NM_032682	NP_116071	Q9H334	FOXP1_HUMAN	forkhead box P1 isoform 1	604					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		CGTTCAGCTCTTCCCGTATTG	0.517			NA	T	PAX5	ALL								13	182					0	0	0.001855	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432636	73432636	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:73432636C>A	uc003dpl.1	-	10	3177	c.3081G>T	c.(3079-3081)AAG>AAT	p.K1027N	PDZRN3_uc011bgh.1_Missense_Mutation_p.K684N|PDZRN3_uc010hoe.1_Missense_Mutation_p.K725N|PDZRN3_uc011bgf.1_Missense_Mutation_p.K744N|PDZRN3_uc011bgg.1_Missense_Mutation_p.K747N	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1027							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TATTCCTCTTCTTCATCATCT	0.458			NA											76	237					7.97268e-31	1.35777e-30	0.00361	1	0
ROBO2	6092	broad.mit.edu	37	3	77147283	77147283	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:77147283C>T	uc003dpy.3	+	2	823	c.180C>T	c.(178-180)CCC>CCT	p.P60P	ROBO2_uc003dpz.2_Silent_p.P60P|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Silent_p.P60P	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	60	Ig-like C2-type 1.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGCCAACGCCCACCATTGAGT	0.592			NA											12	36					0	0	0.000978	0	0
ROBO2	6092	broad.mit.edu	37	3	77542523	77542523	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:77542523C>G	uc003dpy.3	+	5	1439	c.796C>G	c.(796-798)CCA>GCA	p.P266A	ROBO2_uc003dpz.2_Missense_Mutation_p.P266A|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.P266A	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	266	Ig-like C2-type 3.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGCAGACTTGCCAAGAGGAAG	0.418			NA											8	53					0	0	0.004482	0	0
OR5K4	403278	broad.mit.edu	37	3	98072805	98072805	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:98072805G>T	uc011bgv.1	+	1	108	c.108G>T	c.(106-108)CTG>CTT	p.L36L		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						CCATCTATCTGGTCACCATGG	0.458			NA											17	285					4.14922e-12	5.97913e-12	0.004007	1	0
OR5K1	26339	broad.mit.edu	37	3	98188738	98188738	+	Silent	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:98188738T>A	uc003dsm.2	+	1	318	c.318T>A	c.(316-318)ACT>ACA	p.T106T		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	106	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TTCTTTGCACTGTGGAAACTG	0.438			NA											22	219					0	0	0.001882	0	0
CPNE4	131034	broad.mit.edu	37	3	131388541	131388542	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:131388541_131388542CC>AA	uc003eok.2	-	7	1093_1094	c.658_659GG>TT	c.(658-660)GGA>TTA	p.G220L	CPNE4_uc011blq.1_Missense_Mutation_p.G238L|CPNE4_uc003eol.2_Missense_Mutation_p.G238L|CPNE4_uc003eom.2_Missense_Mutation_p.G220L	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	220	C2 2.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						GTCTGGGTCTCCGCTGCATAGA	0.386			NA											67	137					0	0	0.004672	0	0
TRIM42	287015	broad.mit.edu	37	3	140401341	140401341	+	Missense_Mutation	SNP	C	C	A	rs149207203	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:140401341C>A	uc003eto.1	+	2	570	c.379C>A	c.(379-381)CAG>AAG	p.Q127K		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	127						intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						CAGCGATACCCAGGTGGATGA	0.562			NA											19	52					1.2644e-06	1.54814e-06	0.010504	1	0
CCDC39	339829	broad.mit.edu	37	3	180377471	180377471	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr3:180377471G>T	uc010hxe.2	-	5	718	c.603C>A	c.(601-603)AGC>AGA	p.S201R	CCDC39_uc003fkn.2_RNA	NM_181426	NP_852091	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	201	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				ovary(4)	4	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TAACCTGTGCGCTTATAGTCT	0.328			NA											7	94					1.26484e-09	1.71701e-09	0.00308	1	0
PDE6B	5158	broad.mit.edu	37	4	619514	619514	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:619514C>A	uc003gap.2	+	1	152	c.99C>A	c.(97-99)GCC>GCA	p.A33A	PDE6B_uc003gao.3_Silent_p.A33A	NM_000283	NP_000274	P35913	PDE6B_HUMAN	phosphodiesterase 6B isoform 1	33				AAA -> GRG (in Ref. 1; CAA44569, 2; CAA46932 and 3; AAB22690).	cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding				0						AGAATGTGGCCGCGGCCTGCG	0.493	GBM(71;463 1194 9848 25922 46834)		NA											14	48					1.3612e-06	1.65584e-06	0.003163	1	0
PSAPL1	768239	broad.mit.edu	37	4	7435591	7435591	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:7435591A>T	uc011bwj.1	-	1	1110	c.1016T>A	c.(1015-1017)TTG>TAG	p.L339*	SORCS2_uc003gkb.3_Intron|SORCS2_uc011bwi.1_Intron	NM_001085382	NP_001078851	Q6NUJ1	SAPL1_HUMAN	prosaposin-like protein 1	339	Saposin B-type 3.				sphingolipid metabolic process	extracellular region|lysosome					0						GGTGTCCACCAAGATGATGCA	0.582			NA											32	77					0	0	0.002096	0	0
BOD1L	259282	broad.mit.edu	37	4	13605874	13605874	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:13605874C>A	uc003gmz.1	-	10	2767	c.2650G>T	c.(2650-2652)GAT>TAT	p.D884Y	BOD1L_uc010idr.1_Missense_Mutation_p.D221Y	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	884	Lys-rich.						DNA binding			ovary(5)|breast(1)	6						AAATTACTATCCATGTTAGTG	0.373			NA											11	71					3.07112e-06	3.6801e-06	0.000978	1	0
GPR125	166647	broad.mit.edu	37	4	22390174	22390174	+	Silent	SNP	C	C	G	rs12700	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:22390174C>G	uc003gqm.1	-	19	3385	c.3120G>C	c.(3118-3120)GCG>GCC	p.A1040A	GPR125_uc010ieo.1_Silent_p.A896A|GPR125_uc003gql.1_Silent_p.A167A	NM_145290	NP_660333	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125 precursor	1040	Helical; Name=7; (Potential).				neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			skin(1)	1		Breast(46;0.198)				CCACGAAGAACGCACTGAAGC	0.468			NA											11	54					0	0	0.000978	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23814457	23814457	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:23814457C>G	uc003gqs.2	-	10	2052	c.1932G>C	c.(1930-1932)AGG>AGC	p.R644S	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	644					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				CCCTCTTCAGCCTCTCGTGCT	0.448	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											25	144					0	0	0.003954	0	0
SEPSECS	51091	broad.mit.edu	37	4	25125605	25125605	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:25125605G>C	uc003grg.2	-	11	1667	c.1454C>G	c.(1453-1455)GCT>GGT	p.A485G	SEPSECS_uc003gri.2_Missense_Mutation_p.A484G|SEPSECS_uc003grh.2_Missense_Mutation_p.A406G	NM_153825	NP_722547	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine)	485	SLA/LP epitope.				selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding				0		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	TAGTTTTAAAGCCATTTCTTC	0.353			NA											23	88					0	0	0.001882	0	0
WDR19	57728	broad.mit.edu	37	4	39207199	39207199	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:39207199A>T	uc003gtv.2	+	9	887	c.733A>T	c.(733-735)ATC>TTC	p.I245F	WDR19_uc010ifl.1_Missense_Mutation_p.I62F|WDR19_uc003gtu.1_Missense_Mutation_p.I245F|WDR19_uc011byi.1_Missense_Mutation_p.I85F	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	245					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TGATGGCCGCATCATGATTGG	0.378			NA											6	30					0	0	0.001168	0	0
GABRA4	2557	broad.mit.edu	37	4	46979500	46979500	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:46979500C>T	uc003gxg.2	-	4	560	c.421G>A	c.(421-423)GTC>ATC	p.V141I		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	141	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTATGTGAGACAGATTTCTTT	0.299	Ovarian(6;283 369 8234 12290 33402)		NA											8	47					0	0	0.004482	0	0
LPHN3	23284	broad.mit.edu	37	4	62845477	62845477	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:62845477G>A	uc010ihh.2	+	15	2971	c.2798G>A	c.(2797-2799)CGA>CAA	p.R933Q	LPHN3_uc003hcq.3_Missense_Mutation_p.R933Q|LPHN3_uc003hct.2_Missense_Mutation_p.R326Q	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	920	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						GGGATCAACCGAACTGACCAA	0.443			NA											14	136					0	0	0.004007	0	0
EPHA5	2044	broad.mit.edu	37	4	66467644	66467645	+	Nonsense_Mutation	DNP	CC	CC	AG			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:66467644_66467645CC>AG	uc003hcy.2	-	3	817_818	c.624_625GG>CT	c.(622-627)AAGGGA>AACTGA	p.208_209KG>N*	EPHA5_uc003hcx.2_Nonsense_Mutation_p.139_140KG>N*|EPHA5_uc003hcz.2_Nonsense_Mutation_p.208_209KG>N*|EPHA5_uc011cah.1_Nonsense_Mutation_p.208_209KG>N*|EPHA5_uc011cai.1_Nonsense_Mutation_p.208_209KG>N*|EPHA5_uc003hda.2_Nonsense_Mutation_p.208_209KG>N*	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	208_209	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AGATAAAATCCCTTTTTGCTTA	0.416			NA								TSP Lung(17;0.13)			5	73					0	0	0.004672	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69107500	69107500	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:69107500A>T	uc003hdw.3	-	2	167	c.31T>A	c.(31-33)TCT>ACT	p.S11T		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	11	Cytoplasmic (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGTGGCCAAGATCTTTGGGAA	0.403			NA											4	80					0	0	0.009096	0	0
Unknown	0	broad.mit.edu	37	4	69362415	69362415	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:69362415G>T	uc003hdz.3	+	10	1229	c.1165G>T	c.(1165-1167)GCT>TCT	p.A389S		NM_014058	NP_054777			transmembrane protease, serine 11E												NA						CTGGTACCTTGCTGGAATAGT	0.438			NA											76	431					3.78398e-24	6.27315e-24	0.00361	1	0
CCNG2	901	broad.mit.edu	37	4	78081897	78081897	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:78081897C>T	uc003hkq.3	+	4	603	c.300C>T	c.(298-300)TGC>TGT	p.C100C	CCNG2_uc003hkn.3_Silent_p.C100C|CCNG2_uc011ccc.1_Silent_p.C100C|CCNG2_uc003hkp.3_Silent_p.C100C	NM_004354	NP_004345	Q16589	CCNG2_HUMAN	cyclin G2	100					cell cycle checkpoint|cell division|mitosis	cytoplasm				ovary(2)|lung(1)	3						ATTTGTCTTGCATTGGAGTCT	0.363			NA											8	160					0	0	0.004482	0	0
ANXA3	306	broad.mit.edu	37	4	79512740	79512740	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:79512740C>G	uc003hld.2	+	7	756	c.446C>G	c.(445-447)TCT>TGT	p.S149C	ANXA3_uc003hle.2_Missense_Mutation_p.S110C|ANXA3_uc010ijk.2_Missense_Mutation_p.S110C	NM_005139	NP_005130	P12429	ANXA3_HUMAN	annexin A3	149	Annexin 2.				defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity				0						TCCGAAACATCTGGTGACTTC	0.333	GBM(2;126 157 27790 28920 42492)		NA											19	124					0	0	0.001882	0	0
SEC31A	22872	broad.mit.edu	37	4	83799966	83799966	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:83799966T>A	uc003hnf.2	-	4	483	c.319A>T	c.(319-321)ATA>TTA	p.I107L	SEC31A_uc011ccl.1_Missense_Mutation_p.I107L|SEC31A_uc003hnl.2_Missense_Mutation_p.I107L|SEC31A_uc003hng.2_Missense_Mutation_p.I107L|SEC31A_uc003hnh.2_Missense_Mutation_p.I107L|SEC31A_uc003hni.2_Missense_Mutation_p.I107L|SEC31A_uc003hnj.2_Missense_Mutation_p.I107L|SEC31A_uc011ccm.1_Missense_Mutation_p.I102L|SEC31A_uc011ccn.1_Missense_Mutation_p.I107L|SEC31A_uc003hnk.2_Missense_Mutation_p.I107L|SEC31A_uc003hnm.2_Missense_Mutation_p.I107L|SEC31A_uc003hnn.1_Missense_Mutation_p.I107L|SEC31A_uc003hno.2_Missense_Mutation_p.I107L	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	107	WD 1.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TCTCCAGCTATAATTTTAGAA	0.403			NA											14	65					0	0	0.001855	0	0
GRID2	2895	broad.mit.edu	37	4	94690490	94690490	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:94690490C>A	uc011cdt.1	+	15	2748	c.2490C>A	c.(2488-2490)AGC>AGA	p.S830R	GRID2_uc011cdu.1_Missense_Mutation_p.S735R	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	830	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ACATAAAGAGCTTTGCAGGGG	0.532			NA											23	69					3.08376e-08	4.03041e-08	0.00333	1	0
ANK2	287	broad.mit.edu	37	4	114176923	114176923	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:114176923G>T	uc003ibe.3	+	11	1123	c.1023G>T	c.(1021-1023)CAG>CAT	p.Q341H	ANK2_uc003ibd.3_Missense_Mutation_p.Q320H|ANK2_uc003ibf.3_Missense_Mutation_p.Q341H|ANK2_uc003ibc.2_Missense_Mutation_p.Q317H|ANK2_uc011cgb.1_Missense_Mutation_p.Q356H	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	341	ANK 10.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGGCTGCCCAGGGAGACCACG	0.458			NA											28	155					6.04164e-23	9.89914e-23	0.002096	1	0
KIAA1109	84162	broad.mit.edu	37	4	123274259	123274259	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:123274259G>C	uc003ieh.2	+	79	14095	c.14050G>C	c.(14050-14052)GAA>CAA	p.E4684Q	KIAA1109_uc003iem.2_Missense_Mutation_p.E1040Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4684					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTTTCATTTAGAAGAACCAAA	0.368			NA											18	48					0	0	0.006122	0	0
KIAA1109	84162	broad.mit.edu	37	4	123275152	123275152	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:123275152T>C	uc003ieh.2	+	80	14330	c.14285T>C	c.(14284-14286)GTT>GCT	p.V4762A	KIAA1109_uc003iem.2_Missense_Mutation_p.V1118A	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4762					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTCAATTATGTTACAGCTACA	0.358			NA											4	21					0	0	0.009096	0	0
FAT4	79633	broad.mit.edu	37	4	126241342	126241342	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:126241342C>G	uc003ifj.3	+	1	3776	c.3776C>G	c.(3775-3777)GCT>GGT	p.A1259G		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1259	Cadherin 12.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGACAGTTTGCTATAGACAGT	0.378			NA											10	61					0	0	0.006214	0	0
KIAA0922	23240	broad.mit.edu	37	4	154523459	154523459	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:154523459G>T	uc003inm.3	+	22	2471	c.2419G>T	c.(2419-2421)GAC>TAC	p.D807Y	KIAA0922_uc010ipp.2_Missense_Mutation_p.D808Y|KIAA0922_uc010ipq.2_Missense_Mutation_p.D576Y	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	807	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				GTTTTCCCTGGACCCAAACAC	0.408			NA											26	137					8.4185e-14	1.25164e-13	0.002445	1	0
DCHS2	54798	broad.mit.edu	37	4	155219801	155219801	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:155219801G>T	uc003inw.2	-	18	4300	c.4300C>A	c.(4300-4302)CGT>AGT	p.R1434S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1434	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCCAAAGCACGAGTGGTTGAG	0.393			NA											5	90					0.000602214	0.000658452	0.000602	1	0
FGG	2266	broad.mit.edu	37	4	155527940	155527940	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:155527940T>A	uc003ioj.2	-	8	1187	c.1046A>T	c.(1045-1047)GAA>GTA	p.E349V	FGG_uc003iog.2_Missense_Mutation_p.E349V|FGG_uc003ioh.2_Missense_Mutation_p.E357V|FGG_uc010ipx.2_Missense_Mutation_p.E177V|FGG_uc010ipy.2_Missense_Mutation_p.E60V|FGG_uc003ioi.2_Missense_Mutation_p.E60V|FGG_uc003iok.2_Missense_Mutation_p.E357V	NM_021870	NP_068656	P02679	FIBG_HUMAN	fibrinogen, gamma chain isoform gamma-B	349	|Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding				0	all_hematologic(180;0.215)	Renal(120;0.0458)			Sucralfate(DB00364)	ACAGTTGCCTTCAAACTTATC	0.423			NA											14	85					0	0	0.001855	0	0
GRIA2	2891	broad.mit.edu	37	4	158238855	158238855	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:158238855G>A	uc003ipm.3	+	5	1171	c.712G>A	c.(712-714)GCA>ACA	p.A238T	GRIA2_uc011cit.1_Missense_Mutation_p.A191T|GRIA2_uc003ipl.3_Missense_Mutation_p.A238T|GRIA2_uc003ipk.3_Missense_Mutation_p.A191T|GRIA2_uc010iqh.1_RNA	NM_001083619	NP_001077088	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2 isoform 2	238	Extracellular (Potential).				synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			central_nervous_system(3)|ovary(1)	4	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CTACATCATTGCAAATCTGGT	0.254			NA											4	16					0	0	0.001168	0	0
PALLD	23022	broad.mit.edu	37	4	169837113	169837113	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:169837113C>T	uc011cjx.1	+	17	2996	c.2785C>T	c.(2785-2787)CAC>TAC	p.H929Y	CBR4_uc011cjy.1_Intron|PALLD_uc003iru.2_Missense_Mutation_p.H912Y|PALLD_uc003irv.2_Missense_Mutation_p.H530Y|PALLD_uc003irw.2_Missense_Mutation_p.H414Y|PALLD_uc003irx.2_Missense_Mutation_p.H138Y	NM_016081	NP_057165	Q8WX93	PALLD_HUMAN	palladin isoform 2	1136	Ig-like C2-type 4.				cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			ovary(1)	1		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		CTTCAGACCTCACTTCTTGCA	0.423	Esophageal Squamous(109;1482 1532 18347 40239 51172)		NA							Pancreatic_Cancer_Familial_Clustering_of				15	51					0	0	0.004007	0	0
SNX25	83891	broad.mit.edu	37	4	186231802	186231802	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:186231802G>T	uc003ixh.2	+	7	873	c.684G>T	c.(682-684)GCG>GCT	p.A228A	SNX25_uc010ish.2_5'UTR	NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	228					cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AAGAAACTGCGGCAATGAAAG	0.478			NA											12	56					1.61879e-10	2.23528e-10	0.001368	1	0
FAT1	2195	broad.mit.edu	37	4	187524791	187524791	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:187524791T>C	uc003izf.2	-	19	11077	c.10889A>G	c.(10888-10890)CAT>CGT	p.H3630R		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3630	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TTGTCTGATATGCACTGTGAT	0.502	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			13	39					0	0	0.00245	0	0
NKD2	85409	broad.mit.edu	37	5	1037955	1037955	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:1037955G>T	uc003jbt.1	+	10	828	c.823G>T	c.(823-825)GGC>TGC	p.G275C	NKD2_uc010itf.1_3'UTR	NM_033120	NP_149111	Q969F2	NKD2_HUMAN	naked cuticle homolog 2	275					exocytosis|Wnt receptor signaling pathway	cytoplasmic membrane-bounded vesicle|plasma membrane	calcium ion binding|ubiquitin protein ligase binding				0	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;3.28e-09)		Epithelial(17;0.00093)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00417)|Lung(60;0.165)			GGAGCCCCAGGGCAGGGCCTC	0.652			NA											22	53					7.41877e-09	9.85662e-09	0.001882	1	0
DNAH5	1767	broad.mit.edu	37	5	13820510	13820510	+	Silent	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:13820510C>G	uc003jfd.2	-	41	6828	c.6786G>C	c.(6784-6786)GGG>GGC	p.G2262G		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2262	AAA 2 (By similarity).|ATP (Potential).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCCCACTGGGCCCCAGAGTCA	0.532			NA							Kartagener_syndrome				20	46					0	0	0.010504	0	0
PRDM9	56979	broad.mit.edu	37	5	23510114	23510114	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:23510114A>T	uc003jgo.2	+	4	461	c.279A>T	c.(277-279)GAA>GAT	p.E93D		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	93					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						ATTCTGATGAAGAATGGACCC	0.363			NA								HNSCC(3;0.000094)			22	99					0	0	0.001882	0	0
CDH10	1008	broad.mit.edu	37	5	24487878	24487878	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:24487878C>A	uc003jgr.1	-	12	2593	c.2261G>T	c.(2260-2262)GGT>GTT	p.G754V	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	754	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TTCAGTAGTACCTGATTCTAA	0.468			NA								HNSCC(23;0.051)			48	165					1.00776e-21	1.62747e-21	0.00361	1	0
CDH6	1004	broad.mit.edu	37	5	31299613	31299613	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:31299613G>A	uc003jhe.1	+	5	1012	c.686G>A	c.(685-687)AGG>AAG	p.R229K	CDH6_uc003jhd.1_Missense_Mutation_p.R229K	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	229	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CGAGAAAACAGGGAGCAGTAC	0.448			NA											25	120					0	0	0.005443	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33658393	33658393	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:33658393G>T	uc003jia.1	-	7	1249	c.1086C>A	c.(1084-1086)GGC>GGA	p.G362G	ADAMTS12_uc010iuq.1_Silent_p.G362G	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	362	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GGTGAGACAGGCCCAGGGTCT	0.507			NA								HNSCC(64;0.19)			38	185					1.59361e-14	2.40109e-14	0.006999	1	0
RXFP3	51289	broad.mit.edu	37	5	33937505	33937505	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:33937505G>C	uc003jic.1	+	1	1017	c.660G>C	c.(658-660)TGG>TGC	p.W220C		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	220	Helical; Name=4; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						TGTGTGTGTGGATCTGGGCTT	0.677			NA											8	41					0	0	0.00308	0	0
SLC45A2	51151	broad.mit.edu	37	5	33964062	33964062	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:33964062C>A	uc003jid.2	-	3	714	c.622G>T	c.(622-624)GGA>TGA	p.G208*	SLC45A2_uc003jie.2_Nonsense_Mutation_p.G208*|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	208	Extracellular (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AACAGTCTTCCCAGCTCCAGA	0.458	Ovarian(31;380 859 8490 22203 49048)		NA											18	69					8.00594e-06	9.51234e-06	0.007413	1	0
RANBP3L	202151	broad.mit.edu	37	5	36251594	36251594	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:36251594G>T	uc003jkh.2	-	13	1668	c.1175C>A	c.(1174-1176)GCC>GAC	p.A392D	RANBP3L_uc011cow.1_Missense_Mutation_p.A417D	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	392	RanBD1.				intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			TGTATCTTGGGCACTGGCCTG	0.348			NA											13	48					9.05144e-12	1.28783e-11	0.001855	1	0
MAP1B	4131	broad.mit.edu	37	5	71491553	71491553	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:71491553G>T	uc003kbw.3	+	5	2612	c.2371G>T	c.(2371-2373)GCC>TCC	p.A791S	MAP1B_uc010iyw.1_Missense_Mutation_p.A808S|MAP1B_uc010iyx.1_Missense_Mutation_p.A665S|MAP1B_uc010iyy.1_Missense_Mutation_p.A665S	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	791						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GGAAGGCAAGGCCGCAGAGGC	0.527	Melanoma(17;367 822 11631 31730 47712)		NA											10	97					2.17888e-05	2.53002e-05	0.006214	1	0
SV2C	22987	broad.mit.edu	37	5	75597285	75597285	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:75597285A>T	uc003kei.1	+	12	2049	c.1915A>T	c.(1915-1917)ATG>TTG	p.M639L		NM_014979	NP_055794	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	639	Helical; (Potential).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			skin(1)	1		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GATGATAGGCATGCTGTGTCT	0.507			NA											9	164					0	0	0.006214	0	0
RGMB	285704	broad.mit.edu	37	5	98128880	98128880	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:98128880G>A	uc003knc.2	+	5	1262	c.860G>A	c.(859-861)GGC>GAC	p.G287D		NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	246					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		TTTGTGGATGGCACCACCAGT	0.542			NA											3	42					0	0	0.004672	0	0
FBN2	2201	broad.mit.edu	37	5	127681130	127681130	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:127681130T>C	uc003kuu.2	-	24	3575	c.3136A>G	c.(3136-3138)AAG>GAG	p.K1046E	FBN2_uc003kuv.2_Missense_Mutation_p.K1013E	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	1046	TB 5.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TCGTATTCCTTGGTGCCAGGT	0.622			NA											11	118					0	0	0.001855	0	0
PCDHB6	56130	broad.mit.edu	37	5	140531776	140531776	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:140531776C>A	uc003lir.2	+	1	1938	c.1938C>A	c.(1936-1938)GGC>GGA	p.G646G	PCDHB6_uc011dah.1_Silent_p.G510G	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	646	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGACAATGGCGAGCCTCCGC	0.706			NA											17	59					1.55795e-14	2.35367e-14	0.001882	1	0
PCDHB16	57717	broad.mit.edu	37	5	140562573	140562573	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:140562573C>A	uc003liv.2	+	1	1594	c.439C>A	c.(439-441)CCT>ACT	p.P147T	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	147	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAAAACAGTCCTCTAGGAAC	0.388			NA											15	32					2.32078e-09	3.13529e-09	0.003163	1	0
PCDHB12	56124	broad.mit.edu	37	5	140589769	140589769	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:140589769G>T	uc003liz.2	+	1	1479	c.1290G>T	c.(1288-1290)AGG>AGT	p.R430S	PCDHB12_uc011dak.1_Missense_Mutation_p.R93S	NM_018932	NP_061755	Q9Y5F1	PCDBC_HUMAN	protocadherin beta 12 precursor	430	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACCCCCAGGCTAAAAACCG	0.537			NA											14	121					2.61681e-11	3.67662e-11	0.00245	1	0
PCDHGA1	56114	broad.mit.edu	37	5	140711266	140711266	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:140711266G>A	uc003lji.1	+	1	1015	c.1015G>A	c.(1015-1017)GAT>AAT	p.D339N	PCDHGA1_uc011dan.1_Missense_Mutation_p.D339N	NM_018912	NP_061735	Q9Y5H4	PCDG1_HUMAN	protocadherin gamma subfamily A, 1 isoform 1	339	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|breast(1)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAAGTTTTGGATGTAAATGA	0.433			NA											7	42					0	0	0.00308	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730903	140730903	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:140730903G>T	uc003ljo.1	+	1	1076	c.1076G>T	c.(1075-1077)GGA>GTA	p.G359V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc011daq.1_Missense_Mutation_p.G359V	NM_018922	NP_061745	Q9Y5G3	PCDGD_HUMAN	protocadherin gamma subfamily B, 1 isoform 1	359	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGACCTTGGAACTGTAATA	0.418			NA											14	15					1.3612e-06	1.65584e-06	0.003163	1	0
SPINK5	11005	broad.mit.edu	37	5	147493975	147493975	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:147493975C>A	uc003lox.2	+	21	2011	c.1938C>A	c.(1936-1938)TGC>TGA	p.C646*	SPINK5_uc010jgs.1_Nonsense_Mutation_p.C618*|SPINK5_uc010jgr.2_Nonsense_Mutation_p.C627*|SPINK5_uc003low.2_Nonsense_Mutation_p.C646*|SPINK5_uc003loy.2_Nonsense_Mutation_p.C646*	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	646	Kazal-like 10.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACTTTTCTGCACAAGAGAAA	0.428			NA											7	59					0.00198382	0.00212768	0.001984	1	0
SPARC	6678	broad.mit.edu	37	5	151051154	151051154	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:151051154G>T	uc003luh.2	-	4	334	c.310C>A	c.(310-312)CCC>ACC	p.P104T	GM2A_uc011dcs.1_Intron|SPARC_uc003lug.2_Intron|SPARC_uc003lui.2_Missense_Mutation_p.P104T	NM_003118	NP_003109	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich	104	Kazal-like.				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(1)	1		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	TCGCCAATGGGGGCTGGGCAG	0.597			NA											8	198					7.48243e-07	9.30337e-07	0.006214	1	0
DOCK2	1794	broad.mit.edu	37	5	169141163	169141163	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:169141163G>T	uc003maf.2	+	18	1871	c.1791G>T	c.(1789-1791)CGG>CGT	p.R597R	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.R89R|DOCK2_uc010jjl.1_Silent_p.R115R	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	597	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAGCTCCCGGGATGTGTTCT	0.507			NA											15	47					7.93312e-07	9.77722e-07	0.00245	1	0
DOCK2	1794	broad.mit.edu	37	5	169509853	169509853	+	Silent	SNP	G	G	A	rs140198889	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr5:169509853G>A	uc003maf.2	+	52	5564	c.5484G>A	c.(5482-5484)ACG>ACA	p.T1828T	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.T1320T|DOCK2_uc003mah.2_Silent_p.T384T	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1828					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGCTGTCCACGGACCTGTGAG	0.522			NA											12	40					0	0	0.001368	0	0
KIF13A	63971	broad.mit.edu	37	6	17837141	17837141	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:17837141C>T	uc003ncg.3	-	11	1228	c.1123G>A	c.(1123-1125)GAG>AAG	p.E375K	KIF13A_uc003ncf.2_Missense_Mutation_p.E375K|KIF13A_uc003nch.3_Missense_Mutation_p.E375K|KIF13A_uc003nci.3_Missense_Mutation_p.E375K|KIF13A_uc003ncj.2_Missense_Mutation_p.E51K	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	375	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTCAGTTTCTCGACTTCCTCC	0.517			NA											30	353					0	0	0.008361	0	0
ZNF187	7741	broad.mit.edu	37	6	28240024	28240024	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:28240024C>T	uc011dld.1	+	3	598	c.328C>T	c.(328-330)CGG>TGG	p.R110W	ZNF187_uc011dlc.1_Missense_Mutation_p.R110W|ZNF187_uc003nku.3_Intron|ZNF187_uc003nkw.3_5'UTR|ZNF187_uc011dle.1_5'UTR|ZNF187_uc011dlf.1_Intron|ZNF187_uc011dlg.1_5'UTR	NM_001111039	NP_001104509	Q16670	ZN187_HUMAN	zinc finger protein 187 isoform b	110	SCAN box.				viral reproduction	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GCTCCAGGCCCGGGTGCAGGA	0.567			NA											4	27					0	0	0.009096	0	0
HLA-DRA	3122	broad.mit.edu	37	6	32411567	32411567	+	Silent	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:32411567A>T	uc003obh.2	+	4	726	c.645A>T	c.(643-645)ACA>ACT	p.T215T	HLA-DRA_uc003obi.2_Silent_p.T190T	NM_019111	NP_061984	P01903	DRA_HUMAN	major histocompatibility complex, class II, DR	215	Connecting peptide.|Extracellular (Potential).				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|Golgi apparatus|integral to plasma membrane|late endosome membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			ovary(1)|skin(1)	2						CAGAGACTACAGAGAACGTGG	0.502			NA							T-cell_Lymphoma_(Cutaneous)__Familial_Clustering_of|KaposSarcoma_Familial_Clustering_of				7	235					0	0	0.00308	0	0
ZNF76	7629	broad.mit.edu	37	6	35260373	35260373	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:35260373G>A	uc003oki.1	+	10	1179	c.974G>A	c.(973-975)CGC>CAC	p.R325H	ZNF76_uc011dsz.1_Missense_Mutation_p.R325H|ZNF76_uc003okj.1_Missense_Mutation_p.R325H	NM_003427	NP_003418	P36508	ZNF76_HUMAN	zinc finger protein 76 (expressed in testis)	325	C2H2-type 6.				regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCGGGAAACGCTTCACCGAG	0.488	Esophageal Squamous(52;92 1039 20612 23956 34676)		NA											10	49					0	0	0.000978	0	0
LRFN2	57497	broad.mit.edu	37	6	40399507	40399507	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:40399507A>C	uc003oph.1	-	2	1811	c.1346T>G	c.(1345-1347)GTG>GGG	p.V449G		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	449	Fibronectin type-III.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					GTACATCTTCACCCGGGGTGC	0.597			NA											20	41					0	0	0.008871	0	0
MEP1A	4224	broad.mit.edu	37	6	46794188	46794188	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:46794188G>A	uc010jzh.1	+	9	918	c.876G>A	c.(874-876)CAG>CAA	p.Q292Q	MEP1A_uc011dwg.1_Silent_p.Q14Q|MEP1A_uc011dwh.1_Silent_p.Q320Q|MEP1A_uc011dwi.1_Silent_p.Q192Q	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	292	Extracellular (Potential).|MAM.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GGGCCCATCAGGACAGTGCTC	0.493			NA											20	83					0	0	0.008871	0	0
TFAP2D	83741	broad.mit.edu	37	6	50718973	50718973	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:50718973C>A	uc003paf.2	+	7	1587	c.1075C>A	c.(1075-1077)CTG>ATG	p.L359M	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	359	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					TAGATCACCACTGGGATCCTC	0.348			NA											29	36					2.80507e-11	3.9313e-11	0.002445	1	0
COL12A1	1303	broad.mit.edu	37	6	75898142	75898142	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:75898142C>A	uc003phs.2	-	8	1099	c.933G>T	c.(931-933)GAG>GAT	p.E311D	COL12A1_uc003pht.2_Intron|COL12A1_uc003phu.1_5'UTR	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	311	VWFA 1.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GGGAGATGATCTCATTCTGAA	0.433			NA											28	69					2.65835e-16	4.08194e-16	0.007291	1	0
UBE2CBP	90025	broad.mit.edu	37	6	83748197	83748197	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:83748197T>A	uc003pjp.2	-	5	713	c.605A>T	c.(604-606)AAG>ATG	p.K202M	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_Missense_Mutation_p.K170M	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	202						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		GGTATTTGCCTTTGGTTCCTG	0.338			NA											18	55					0	0	0.007413	0	0
UBE2J1	51465	broad.mit.edu	37	6	90039587	90039587	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:90039587C>A	uc010kcb.2	-	9	941	c.768G>T	c.(766-768)CGG>CGT	p.R256R	UBE2J1_uc003pnc.2_Silent_p.R256R	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	256	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		GCTGCTGGGCCCGGCGCTGTC	0.522			NA											30	42					2.47511e-08	3.25763e-08	0.008361	1	0
ZUFSP	221302	broad.mit.edu	37	6	116988239	116988239	+	Silent	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:116988239C>G	uc003pxf.1	-	2	363	c.117G>C	c.(115-117)GTG>GTC	p.V39V	ZUFSP_uc010kef.1_Intron	NM_145062	NP_659499	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	39						intracellular	zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		CATCATAATTCACACCTGACA	0.343			NA											26	50					0	0	0.00333	0	0
DCBLD1	285761	broad.mit.edu	37	6	117861841	117861841	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:117861841G>T	uc003pxs.2	+	10	1237	c.1112G>T	c.(1111-1113)GGT>GTT	p.G371V	GOPC_uc003pxq.1_Intron|DCBLD1_uc003pxr.1_Missense_Mutation_p.G371V|DCBLD1_uc003pxt.1_Missense_Mutation_p.G26V	NM_173674	NP_775945	Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	371	F5/8 type C.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(1)	1		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		GTGTTTCAGGGTAACTCTAAC	0.428			NA											12	100					2.27111e-07	2.8877e-07	0.001368	1	0
ENPP1	5167	broad.mit.edu	37	6	132211593	132211593	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:132211593C>T	uc011ecf.1	+	25	2740	c.2720C>T	c.(2719-2721)CCA>CTA	p.P907L		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	907	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	AGAAAAGAGCCAGTTTCAGAC	0.383	Colon(104;336 1535 5856 11019 33782)		NA											23	49					0	0	0.00333	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599628	136599628	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:136599628G>A	uc003qgx.1	-	4	644	c.391C>T	c.(391-393)CGG>TGG	p.R131W	BCLAF1_uc003qgw.1_Missense_Mutation_p.R131W|BCLAF1_uc003qgy.1_Missense_Mutation_p.R129W|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.R129W	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	131					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		CTATATGACCGGCGAGATCTG	0.453	Colon(142;1534 1789 5427 7063 28491)		NA											50	356					0	0	0.00361	0	0
TNFAIP3	7128	broad.mit.edu	37	6	138199923	138199923	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:138199923G>T	uc003qhr.2	+	7	1407	c.1341G>T	c.(1339-1341)GCG>GCT	p.A447A	TNFAIP3_uc003qhs.2_Silent_p.A447A	NM_006290	NP_006281	P21580	TNAP3_HUMAN	tumor necrosis factor, alpha-induced protein 3	447	Interaction with NAF1 (By similarity).				anti-apoptosis|apoptosis|B-1 B cell homeostasis|negative regulation of B cell activation|negative regulation of bone resorption|negative regulation of CD40 signaling pathway|negative regulation of endothelial cell apoptosis|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of interleukin-2 production|negative regulation of interleukin-6 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of osteoclast proliferation|negative regulation of protein ubiquitination|negative regulation of smooth muscle cell proliferation|negative regulation of toll-like receptor 2 signaling pathway|negative regulation of toll-like receptor 3 signaling pathway|negative regulation of tumor necrosis factor production|negative regulation of type I interferon production|positive regulation of protein catabolic process|protein K48-linked ubiquitination|protein K63-linked deubiquitination|protein oligomerization|regulation of defense response to virus by host|regulation of germinal center formation|regulation of vascular wound healing|tolerance induction to lipopolysaccharide	centrosome|cytosol|nucleus	caspase inhibitor activity|DNA binding|protease binding|protein self-association|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-protein ligase activity|ubiquitin-specific protease activity|zinc ion binding	p.0?(22)		haematopoietic_and_lymphoid_tissue(133)|lung(3)|ovary(1)	137	Breast(32;0.135)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000849)|OV - Ovarian serous cystadenocarcinoma(155;0.00468)		AGCCCTTGGCGTGGAACCCTG	0.627	GBM(130;153 1739 22295 28918 47987)		NA	D|N|F		marginal zone B-cell lymphomas|Hodgkin's lymphoma|primary mediastinal B cell lymphoma								17	34					4.14922e-12	5.97913e-12	0.004007	1	0
ECT2L	345930	broad.mit.edu	37	6	139167715	139167715	+	Silent	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:139167715A>G	uc003qif.1	+	6	907	c.804A>G	c.(802-804)TCA>TCG	p.S268S	ECT2L_uc011edq.1_Silent_p.S199S	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	268					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CTTTATTATCAAAGAAAAATT	0.368			NA											10	148					0	0	0.006214	0	0
IGF2R	3482	broad.mit.edu	37	6	160494947	160494947	+	Silent	SNP	C	C	T	rs140485195		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:160494947C>T	uc003qta.2	+	35	5254	c.5106C>T	c.(5104-5106)CAC>CAT	p.H1702H		NM_000876	NP_000867	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor precursor	1702	Lumenal (Potential).|12.				receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			ovary(3)	3		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		ATCCCATGCACGGAGTGCCCT	0.478			NA											7	39					0	0	0.001984	0	0
PDE10A	10846	broad.mit.edu	37	6	165827065	165827065	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr6:165827065C>G	uc003qun.2	-	14	1413	c.1172G>C	c.(1171-1173)AGT>ACT	p.S391T	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.S321T|PDE10A_uc003quo.2_Missense_Mutation_p.S401T	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	391	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	AGAGAAGGCACTGCCACTGAT	0.443	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											18	43					0	0	0.006122	0	0
DGKB	1607	broad.mit.edu	37	7	14188795	14188795	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:14188795G>T	uc003ssz.2	-	25	2563	c.2376C>A	c.(2374-2376)TGC>TGA	p.C792*	DGKB_uc011jxt.1_Nonsense_Mutation_p.C773*	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	792					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TGACGAGGGAGCAGAATAAAC	0.363			NA											62	140					2.26907e-38	3.89974e-38	0.00361	1	0
FKBP9	11328	broad.mit.edu	37	7	33014277	33014277	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:33014277G>A	uc003tdh.2	+	2	451	c.270G>A	c.(268-270)CTG>CTA	p.L90L	AVL9_uc011kai.1_Intron|FKBP9_uc011kak.1_Intron|FKBP9_uc011kal.1_Silent_p.L143L|FKBP9_uc003tdg.2_Silent_p.L90L|FKBP9_uc010kwm.2_5'UTR	NM_007270	NP_009201	O95302	FKBP9_HUMAN	FK506 binding protein 9 precursor	90	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|ovary(1)	14			GBM - Glioblastoma multiforme(11;0.0156)			AAGGACAGCTGATCACAGGGA	0.463			NA											21	406					0	0	0.002445	0	0
TBX20	57057	broad.mit.edu	37	7	35271187	35271187	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:35271187C>T	uc011kas.1	-	6	830	c.819G>A	c.(817-819)ACG>ACA	p.T273T		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	273	T-box.					nucleus	DNA binding			central_nervous_system(1)	1						TTTTCAGCTTCGTTATCTGGA	0.373			NA											14	41					0	0	0.003163	0	0
HECW1	23072	broad.mit.edu	37	7	43590144	43590144	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:43590144G>A	uc003tid.1	+	27	4954	c.4349G>A	c.(4348-4350)CGC>CAC	p.R1450H	HECW1_uc011kbi.1_Missense_Mutation_p.R1416H	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1450	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CGGGTGGAGCGCGGCGTGGTA	0.627			NA											9	20					0	0	0.004482	0	0
HECW1	23072	broad.mit.edu	37	7	43594285	43594285	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:43594285G>A	uc003tid.1	+	29	5210	c.4605G>A	c.(4603-4605)ACG>ACA	p.T1535T	HECW1_uc011kbi.1_Silent_p.T1501T	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1535	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AGTTTGTCACGGGAACATCCA	0.557			NA											22	41					0	0	0.00278	0	0
TBRG4	9238	broad.mit.edu	37	7	45145176	45145176	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:45145176G>T	uc003tmv.2	-	3	725	c.599C>A	c.(598-600)TCG>TAG	p.S200*	TBRG4_uc003tmu.2_Nonsense_Mutation_p.S25*|TBRG4_uc003tmw.2_Nonsense_Mutation_p.S200*|TBRG4_uc003tmx.2_Nonsense_Mutation_p.S200*|TBRG4_uc011kcd.1_Nonsense_Mutation_p.S211*|SNORA5A_uc003tmy.2_5'Flank|SNORA5C_uc003tmz.1_5'Flank	NM_004749	NP_004740	Q969Z0	TBRG4_HUMAN	cell cycle progression 2 protein isoform 1	200					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity				0						CAGCTCCTGCGAGTGCTGCTC	0.582			NA											13	254					7.03913e-09	9.37438e-09	0.001368	1	0
LOC643955	643955	broad.mit.edu	37	7	62753165	62753165	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:62753165T>C	uc011kdj.1	-	3	271	c.203A>G	c.(202-204)GAG>GGG	p.E68G		NR_003952				Homo sapiens cDNA clone IMAGE:30377995, containing frame-shift errors.												0						GATGCCCTGCTCTGGCTGAAG	0.368			NA											7	284					0	0	0.000978	0	0
AUTS2	26053	broad.mit.edu	37	7	70231185	70231185	+	Silent	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:70231185C>G	uc003tvw.3	+	9	2297	c.1554C>G	c.(1552-1554)CCC>CCG	p.P518P	AUTS2_uc003tvx.3_Silent_p.P518P|AUTS2_uc011keg.1_5'Flank	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	518										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GCCCTCCGCCCTACCTGCGGA	0.453			NA											19	65					0	0	0.001882	0	0
POM121C	100101267	broad.mit.edu	37	7	75052311	75052311	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:75052311G>A	uc003udk.3	-	13	2109	c.1224C>T	c.(1222-1224)GCC>GCT	p.A408A		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	650	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						TGGTGTCAGTGGCTGGTACCA	0.627			NA											20	53					0	0	0.005443	0	0
CROT	54677	broad.mit.edu	37	7	87011309	87011309	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:87011309G>T	uc003uit.2	+	11	1307	c.1062G>T	c.(1060-1062)AAG>AAT	p.K354N	CROT_uc003uiu.2_Missense_Mutation_p.K382N	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	354					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	GAAGATGGAAGGTATGTTTGA	0.313			NA											12	40					2.80697e-09	3.78302e-09	0.000978	1	0
COL1A2	1278	broad.mit.edu	37	7	94054501	94054501	+	Nonsense_Mutation	SNP	G	G	T	rs72659308		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:94054501G>T	uc003ung.1	+	42	3217	c.2746G>T	c.(2746-2748)GGA>TGA	p.G916*	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	916					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GGGTAGTCCTGGAGTCAACGG	0.507			NA								HNSCC(75;0.22)			22	67					2.21704e-12	3.2363e-12	0.00278	1	0
COL1A2	1278	broad.mit.edu	37	7	94057055	94057055	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:94057055C>A	uc003ung.1	+	49	3855	c.3384C>A	c.(3382-3384)CTC>CTA	p.L1128L	COL1A2_uc011kib.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	1128					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CACCTTCTCTCAGACCCAAGG	0.522			NA								HNSCC(75;0.22)			27	100					7.07758e-08	9.16498e-08	0.004656	1	0
ASNS	440	broad.mit.edu	37	7	97481664	97481664	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:97481664G>A	uc003uot.3	-	13	2099	c.1593C>T	c.(1591-1593)GAC>GAT	p.D531D	ASNS_uc011kin.1_Silent_p.D448D|ASNS_uc003uou.3_Silent_p.D531D|ASNS_uc003uov.3_Silent_p.D531D|ASNS_uc011kio.1_Silent_p.D510D|ASNS_uc003uow.3_Silent_p.D510D|ASNS_uc003uox.3_Silent_p.D448D	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	531	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGCTCAGCCAGTCAGCCCGGC	0.507	Melanoma(70;6 1280 3108 3799 51123)|GBM(6;275 291 425 9929 27738)		NA											22	72					0	0	0.001882	0	0
TRRAP	8295	broad.mit.edu	37	7	98602013	98602013	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:98602013A>T	uc003upp.2	+	67	10677	c.10468A>T	c.(10468-10470)ACG>TCG	p.T3490S	TRRAP_uc011kis.1_Missense_Mutation_p.T3461S|TRRAP_uc003upr.2_Missense_Mutation_p.T3196S	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	3490					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GCCAAAGCCAACGCATTATTA	0.532			NA											26	93					0	0	0.005443	0	0
PILRB	29990	broad.mit.edu	37	7	99956683	99956683	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:99956683C>T	uc003uuk.2	+	16	2931	c.435C>T	c.(433-435)ACC>ACT	p.T145T	PILRB_uc003uul.2_Nonsense_Mutation_p.Q76*|PILRB_uc003uum.1_RNA|PILRB_uc003uun.2_Silent_p.T145T	NM_013440	NP_038468	Q9UKJ0	PILRB_HUMAN	paired immunoglobulin-like type 2 receptor beta	145	Extracellular (Potential).				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCAAGGGGACCAAACTCACCA	0.567			NA											20	48					0	0	0.007413	0	0
ZAN	7455	broad.mit.edu	37	7	100364781	100364781	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:100364781C>T	uc003uwj.2	+	25	4926	c.4761C>T	c.(4759-4761)AAC>AAT	p.N1587N	ZAN_uc003uwk.2_Silent_p.N1587N|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Silent_p.N164N	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1587	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GCGCCACCAACGAGAACCGCG	0.577			NA											5	79					0	0	0.000602	0	0
CDHR3	222256	broad.mit.edu	37	7	105662683	105662683	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:105662683G>T	uc003vdl.3	+	14	1973	c.1865G>T	c.(1864-1866)GGT>GTT	p.G622V	CDHR3_uc003vdk.2_Intron|CDHR3_uc003vdm.3_Missense_Mutation_p.G609V|CDHR3_uc011klt.1_Missense_Mutation_p.G534V|CDHR3_uc003vdn.2_Intron	NM_152750	NP_689963	Q6ZTQ4	CDHR3_HUMAN	hypothetical protein LOC222256 precursor	622	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						CCCAATGCTGGTTCCAATGTC	0.428			NA											43	141					1.15505e-17	1.7932e-17	0.009718	1	0
LAMB4	22798	broad.mit.edu	37	7	107752392	107752392	+	Splice_Site	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:107752392C>A	uc010ljo.1	-	4	277	c.193_splice	c.e4-1	p.G65_splice	LAMB4_uc003vey.2_Splice_Site_p.G65_splice	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor						cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TTTGTTCCCCCTGGAAAACAC	0.338			NA											18	71					0.00074312	0.000809367	0.006122	1	0
LAMB4	22798	broad.mit.edu	37	7	107756565	107756565	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:107756565C>A	uc010ljo.1	-	3	160	c.76G>T	c.(76-78)GGT>TGT	p.G26C	LAMB4_uc003vey.2_Missense_Mutation_p.G26C	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	26	Laminin N-terminal.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGACAGGCACCCCTGTTGCAG	0.532			NA											25	109					2.44723e-14	3.67739e-14	0.004656	1	0
C7orf58	79974	broad.mit.edu	37	7	120704291	120704291	+	Splice_Site	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:120704291G>T	uc003vjq.3	+	5	988	c.541_splice	c.e5-1	p.A181_splice	C7orf58_uc003vjr.1_Splice_Site_p.A181_splice|C7orf58_uc003vjs.3_Splice_Site_p.A181_splice|C7orf58_uc003vjt.3_Splice_Site	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1							endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ATTCCTTTCAGGCAAACAGAT	0.393			NA											30	94					5.8336e-16	8.88478e-16	0.003271	1	0
ZYX	7791	broad.mit.edu	37	7	143080351	143080351	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:143080351G>T	uc003wcw.2	+	5	1114	c.959G>T	c.(958-960)AGG>ATG	p.R320M	ZYX_uc011ktd.1_Missense_Mutation_p.R163M|ZYX_uc003wcx.2_Missense_Mutation_p.R320M|ZYX_uc011kte.1_Missense_Mutation_p.R289M|ZYX_uc011ktf.1_Missense_Mutation_p.R163M	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	320					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					GCCCAGCAGAGGGAGAAGCCC	0.592			NA											29	73					1.32181e-22	2.14698e-22	0.007291	1	0
ZYX	7791	broad.mit.edu	37	7	143080397	143080397	+	Silent	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:143080397G>C	uc003wcw.2	+	5	1160	c.1005G>C	c.(1003-1005)CCG>CCC	p.P335P	ZYX_uc011ktd.1_Silent_p.P178P|ZYX_uc003wcx.2_Silent_p.P335P|ZYX_uc011kte.1_Silent_p.P304P|ZYX_uc011ktf.1_Silent_p.P178P	NM_001010972	NP_001010972	Q15942	ZYX_HUMAN	zyxin	335					cell adhesion|cell-cell signaling|interspecies interaction between organisms|signal transduction	cell-cell adherens junction|cytoplasm|focal adhesion|integral to plasma membrane|nucleus|stress fiber	protein binding|zinc ion binding				0	Melanoma(164;0.205)					TGCCCCCACCGGCTCAGAACC	0.617			NA											15	48					0	0	0.00245	0	0
OR2A12	346525	broad.mit.edu	37	7	143792543	143792543	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:143792543G>T	uc011kty.1	+	1	343	c.343G>T	c.(343-345)GTG>TTG	p.V115L		NM_001004135	NP_001004135	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	Melanoma(164;0.0783)					TCTGATTTTGGTGATGATGTG	0.433			NA											49	116					1.61004e-24	2.68499e-24	0.00361	1	0
OR2A14	135941	broad.mit.edu	37	7	143826593	143826593	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:143826593C>T	uc011kua.1	+	1	388	c.388C>T	c.(388-390)CGT>TGT	p.R130C		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					CCACCCCTTACGTTACAATAG	0.498			NA											12	268					0	0	0.000978	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144077006	144077006	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:144077006G>T	uc003wel.2	+	15	4769	c.4651G>T	c.(4651-4653)GTG>TTG	p.V1551L	ARHGEF5_uc003wem.2_Missense_Mutation_p.V352L	NM_005435	NP_005426	Q12774	ARHG5_HUMAN	rho guanine nucleotide exchange factor 5	1551	SH3.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			skin(2)	2	Melanoma(164;0.14)					GCTGGAGGGCGTGAGGCTCTC	0.567			NA											7	241					1.12685e-05	1.33324e-05	0.004482	1	0
GIMAP8	155038	broad.mit.edu	37	7	150163825	150163825	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:150163825C>A	uc003whj.2	+	2	369	c.39C>A	c.(37-39)CTC>CTA	p.L13L		NM_175571	NP_783161	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	13	Poly-Leu.					endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		AACTGCGGCTCCTCCTCCTGG	0.498			NA											32	70					1.74807e-11	2.4746e-11	0.002096	1	0
NCAPG2	54892	broad.mit.edu	37	7	158468339	158468339	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:158468339C>A	uc003wnv.1	-	12	1301	c.1156G>T	c.(1156-1158)GAA>TAA	p.E386*	NCAPG2_uc010lqu.1_Nonsense_Mutation_p.E178*|NCAPG2_uc003wnw.1_Intron|NCAPG2_uc003wnx.1_Nonsense_Mutation_p.E386*|NCAPG2_uc011kwe.1_Nonsense_Mutation_p.E386*	NM_017760	NP_060230	Q86XI2	CNDG2_HUMAN	leucine zipper protein 5	386					cell division|chromosome condensation|mitosis	nucleus	methylated histone residue binding			ovary(1)|breast(1)|kidney(1)	3	Ovarian(565;0.152)	all_cancers(7;3.44e-11)|all_epithelial(9;3.05e-05)|all_hematologic(28;0.014)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.187)|STAD - Stomach adenocarcinoma(7;0.18)		TAAGGATCTTCTAAAAGGCTC	0.443			NA											14	47					3.27435e-08	4.26957e-08	0.00245	1	0
ZNF596	169270	broad.mit.edu	37	8	195623	195623	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:195623C>A	uc003wot.2	+	6	1064	c.776C>A	c.(775-777)GCC>GAC	p.A259D	ZNF596_uc003wou.2_Missense_Mutation_p.A158D|ZNF596_uc003wov.2_Missense_Mutation_p.A259D|ZNF596_uc003wow.2_Missense_Mutation_p.A259D	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	259	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		TGTGGGAAAGCCTTCAGTAAA	0.418			NA											10	75					0.000442599	0.000487727	0.006214	1	0
DLGAP2	9228	broad.mit.edu	37	8	1497404	1497404	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:1497404G>C	uc003wpl.2	+	2	642	c.545G>C	c.(544-546)CGG>CCG	p.R182P	DLGAP2_uc003wpm.2_Missense_Mutation_p.R182P	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	261					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCGGACGGCCGGGCGGACGAC	0.667			NA											3	20					0	0	0.004672	0	0
DLGAP2	9228	broad.mit.edu	37	8	1616686	1616686	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:1616686G>T	uc003wpl.2	+	6	1859	c.1762G>T	c.(1762-1764)GAC>TAC	p.D588Y	DLGAP2_uc003wpm.2_Missense_Mutation_p.D588Y	NM_004745	NP_004736	Q9P1A6	DLGP2_HUMAN	discs large-associated protein 2	667					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding				0		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GGACAGCCTGGACAGCAACAA	0.667			NA											7	5					2.7689e-08	3.62732e-08	0.001984	1	0
MYOM2	9172	broad.mit.edu	37	8	2026987	2026987	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:2026987G>C	uc003wpx.3	+	12	1573	c.1435G>C	c.(1435-1437)GAC>CAC	p.D479H	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	479					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GGCTGCACTTGACCCCTTGGA	0.527			NA											8	210					0	0	0.00308	0	0
GATA4	2626	broad.mit.edu	37	8	11606502	11606502	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:11606502G>T	uc003wuc.2	+	3	1245	c.691G>T	c.(691-693)GAT>TAT	p.D231Y	GATA4_uc003wub.1_Missense_Mutation_p.D25Y|GATA4_uc011kxc.1_Missense_Mutation_p.D232Y	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	231	GATA-type 1.				atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CTGGAGGCGAGATGGGACGGG	0.577			NA											12	143					0.00010058	0.000113506	0.001368	1	0
C8orf80	389643	broad.mit.edu	37	8	27922222	27922222	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:27922222G>A	uc003xgm.3	-	7	881	c.738C>T	c.(736-738)GAC>GAT	p.D246D		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	246						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		GGATGTAGGGGTCCAGCTTGA	0.562			NA											27	30					0	0	0.005443	0	0
PPP2CB	5516	broad.mit.edu	37	8	30669865	30669865	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:30669865C>G	uc003xik.2	-	2	308	c.73G>C	c.(73-75)GAG>CAG	p.E25Q		NM_004156	NP_004147	P62714	PP2AB_HUMAN	protein phosphatase 2, catalytic subunit, beta	25					protein dephosphorylation	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex|spindle pole	metal ion binding				0				KIRC - Kidney renal clear cell carcinoma(542;0.095)|Kidney(114;0.114)	Vitamin E(DB00163)	ACTTGGTTCTCGTTCAGCTGC	0.642			NA											3	16					0	0	0.009096	0	0
TEX15	56154	broad.mit.edu	37	8	30706087	30706087	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:30706087A>T	uc003xil.2	-	1	447	c.447T>A	c.(445-447)TGT>TGA	p.C149*		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	149										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CTTGGTCCTTACATTGCCCTG	0.433			NA											35	63					0	0	0.002836	0	0
DUSP26	78986	broad.mit.edu	37	8	33451145	33451145	+	Silent	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:33451145C>G	uc003xjp.2	-	3	675	c.342G>C	c.(340-342)CTG>CTC	p.L114L	DUSP26_uc003xjq.2_Silent_p.L114L	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	114	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CCTCAACACCCAGGTAGCGGA	0.662			NA											21	39					0	0	0.008871	0	0
UNC5D	137970	broad.mit.edu	37	8	35631950	35631950	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:35631950A>G	uc003xjr.1	+	16	2940	c.2612A>G	c.(2611-2613)AAA>AGA	p.K871R	UNC5D_uc003xjs.1_Missense_Mutation_p.K866R|UNC5D_uc003xju.1_Missense_Mutation_p.K447R	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	871	Death.|Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCAATGCCAAAGGCAAGGAC	0.468			NA											9	63					0	0	0.004482	0	0
PRDM14	63978	broad.mit.edu	37	8	70971045	70971045	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:70971045C>A	uc003xym.2	-	6	1418	c.1216G>T	c.(1216-1218)GGG>TGG	p.G406W		NM_024504	NP_078780	Q9GZV8	PRD14_HUMAN	PR domain containing 14	406	C2H2-type 1; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			AATACCTTCCCACATCTTTCA	0.438	NSCLC(129;99 1813 5906 40656 46114)		NA											13	71					0.00244969	0.00262234	0.00245	1	0
ZFHX4	79776	broad.mit.edu	37	8	77765759	77765759	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:77765759C>T	uc003yav.2	+	10	6854	c.6467C>T	c.(6466-6468)ACG>ATG	p.T2156M	ZFHX4_uc003yau.1_Missense_Mutation_p.T2201M|ZFHX4_uc003yaw.1_Missense_Mutation_p.T2156M	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2156						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCTCCTATAACGGTTTTAGAA	0.358			NA								HNSCC(33;0.089)			10	229					0	0	0.001368	0	0
ZFHX4	79776	broad.mit.edu	37	8	77776250	77776250	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:77776250G>T	uc003yav.2	+	11	10552	c.10165G>T	c.(10165-10167)GAC>TAC	p.D3389Y		NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	3385						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCTTTGATTGACCCACAAGA	0.448			NA								HNSCC(33;0.089)			10	35					3.07112e-06	3.6801e-06	0.000978	1	0
SLC10A5	347051	broad.mit.edu	37	8	82606414	82606415	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:82606414_82606415CC>AA	uc011lfs.1	-	1	793_794	c.793_794GG>TT	c.(793-795)GGT>TTT	p.G265F		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	265	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity				0						ATGGAATGTACCTGACAACCCT	0.351			NA											18	85					0	0	0.004672	0	0
REXO1L1	254958	broad.mit.edu	37	8	86573790	86573790	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:86573790C>A	uc011lfw.1	-	1	1479	c.1433G>T	c.(1432-1434)TGC>TTC	p.C478F		NM_172239	NP_758439	Q8IX06	GOR_HUMAN	exonuclease GOR	646						cytoplasm|nucleus	exonuclease activity|nucleic acid binding				0						CAGCTGCAGGCAGGCGCTTGC	0.682			NA											7	134					8.12818e-05	9.24704e-05	0.001984	1	0
SPAG1	6674	broad.mit.edu	37	8	101196189	101196189	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:101196189A>T	uc003yjh.1	+	6	580	c.494A>T	c.(493-495)GAC>GTC	p.D165V	SPAG1_uc003yjg.1_Missense_Mutation_p.D165V|SPAG1_uc003yji.1_Missense_Mutation_p.D165V	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	165					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TTAAGATTTGACGTGGAGAAG	0.279			NA											20	51					0	0	0.010504	0	0
SNX31	169166	broad.mit.edu	37	8	101612589	101612589	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:101612589G>T	uc003yjr.2	-	9	913	c.762C>A	c.(760-762)GAC>GAA	p.D254E	SNX31_uc011lha.1_Missense_Mutation_p.D49E|SNX31_uc011lhb.1_Missense_Mutation_p.D155E	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	254					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			TTGTTTGACTGTCTTCTTTCT	0.368			NA											6	132					3.59834e-05	4.16104e-05	0.001168	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110431379	110431379	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:110431379G>T	uc003yne.2	+	22	2518	c.2414G>T	c.(2413-2415)GGG>GTG	p.G805V		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	805	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAATACACTGGGACAAATGTT	0.378			NA								HNSCC(38;0.096)			10	60					1.61879e-10	2.23528e-10	0.001368	1	0
CSMD3	114788	broad.mit.edu	37	8	113668560	113668560	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:113668560C>A	uc003ynu.2	-	18	2986	c.2827G>T	c.(2827-2829)GAA>TAA	p.E943*	CSMD3_uc003yns.2_Nonsense_Mutation_p.E215*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.E903*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.E839*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	943	Extracellular (Potential).|CUB 5.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TAATTCAGTTCAGTCTGAAAT	0.338			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	67					7.48243e-07	9.30337e-07	0.006214	1	0
FER1L6	654463	broad.mit.edu	37	8	125076699	125076699	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:125076699C>A	uc003yqw.2	+	26	3646	c.3440C>A	c.(3439-3441)CCC>CAC	p.P1147H	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1147	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ACAGTGGTGCCCGACTCTGCC	0.607			NA											46	71					4.75955e-12	6.84109e-12	0.00361	1	0
FAM49B	51571	broad.mit.edu	37	8	130891660	130891660	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:130891660C>A	uc003yss.2	-	6	597	c.48G>T	c.(46-48)GGG>GGT	p.G16G	FAM49B_uc003yst.2_Silent_p.G16G|FAM49B_uc003ysu.2_Silent_p.G16G|FAM49B_uc003ysv.2_Intron|FAM49B_uc003ysw.2_Silent_p.G16G|FAM49B_uc003ysx.2_Silent_p.G16G|FAM49B_uc003ysy.1_Silent_p.G16G	NM_016623	NP_057707	Q9NUQ9	FA49B_HUMAN	hypothetical protein LOC51571	16											0	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			AAAAATTTGGCCCCTGCTCAA	0.358			NA											9	66					2.17888e-05	2.53002e-05	0.006214	1	0
LRRC6	23639	broad.mit.edu	37	8	133650267	133650267	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:133650267G>A	uc003ytk.2	-	4	417	c.343C>T	c.(343-345)CTG>TTG	p.L115L	LRRC6_uc003ytl.2_RNA	NM_012472	NP_036604	Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	115						cytoplasm				ovary(1)|kidney(1)	2	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AGCTCCTTCAGATGGATATTG	0.423			NA											27	64					0	0	0.004656	0	0
FAM83H	286077	broad.mit.edu	37	8	144811484	144811484	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:144811484C>T	uc003yzk.2	-	3	526	c.457G>A	c.(457-459)GTG>ATG	p.V153M	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	153					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TCCATCACCACGGCCACCACC	0.647			NA											5	61					0	0	0.000602	0	0
AQP7	364	broad.mit.edu	37	9	33386153	33386153	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:33386153G>A	uc003zst.2	-	6	619	c.447C>T	c.(445-447)ACC>ACT	p.T149T	SUGT1P1_uc010mjq.1_Intron|AQP7_uc003zsu.1_Silent_p.T92T|AQP7_uc010mjs.2_Silent_p.T57T|AQP7_uc010mjt.2_Silent_p.T57T|AQP7_uc011lnx.1_Silent_p.T149T|AQP7_uc011lny.1_Silent_p.T148T|AQP7_uc003zss.3_Silent_p.T57T|AQP7_uc011lnz.1_Silent_p.T57T|AQP7_uc011loa.1_Intron	NM_001170	NP_001161	O14520	AQP7_HUMAN	aquaporin 7	149	Extracellular (Potential).				excretion|generation of precursor metabolites and energy	cell-cell junction|cytoplasm|integral to plasma membrane	glycerol channel activity|water channel activity				0			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.191)		CGACGGGACCGGTCACCATCA	0.577			NA											12	87					0	0	0.00245	0	0
ARID3C	138715	broad.mit.edu	37	9	34627776	34627776	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:34627776C>A	uc011lon.1	-	1	236	c.236G>T	c.(235-237)GGG>GTG	p.G79V		NM_001017363	NP_001017363	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT- like)	79					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		GCCCTGGGCCCCTGGACGGCT	0.398			NA											17	29					1.67942e-08	2.21557e-08	0.006122	1	0
FAM75A6	389730	broad.mit.edu	37	9	43627706	43627706	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:43627706G>A	uc011lrb.1	-	4	1010	c.981C>T	c.(979-981)GTC>GTT	p.V327V		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	327						integral to membrane					0						GTATCCCCACGACATTCTGGC	0.458			NA											24	342					0	0	0.002299	0	0
TRPM6	140803	broad.mit.edu	37	9	77377953	77377953	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:77377953G>A	uc004ajl.1	-	26	3872	c.3634C>T	c.(3634-3636)CAG>TAG	p.Q1212*	TRPM6_uc004ajk.1_Nonsense_Mutation_p.Q1207*|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Intron|TRPM6_uc010mpd.1_Intron|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Nonsense_Mutation_p.Q168*	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1212	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GAGAGATCCTGCAGGTGTCCC	0.468			NA											24	114					0	0	0.004656	0	0
FLJ46321	389763	broad.mit.edu	37	9	84605870	84605870	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:84605870C>T	uc004amn.2	+	4	532	c.485C>T	c.(484-486)TCG>TTG	p.S162L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	162						integral to membrane					0						TTGGCTTCTTCGGCTTCTGCG	0.562			NA											17	69					0	0	0.006122	0	0
FLJ46321	389763	broad.mit.edu	37	9	84609108	84609108	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:84609108C>A	uc004amn.2	+	4	3770	c.3723C>A	c.(3721-3723)TCC>TCA	p.S1241S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	1241						integral to membrane					0						TGACTAATTCCCAGGGCATCT	0.522			NA											55	258					1.78197e-24	2.96291e-24	0.00361	1	0
KIAA1529	57653	broad.mit.edu	37	9	100056343	100056343	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:100056343C>T	uc011lut.1	+	11	974	c.201C>T	c.(199-201)GCC>GCT	p.A67A	KIAA1529_uc011lur.1_RNA|KIAA1529_uc004axe.1_Silent_p.A67A|KIAA1529_uc011lus.1_Intron|KIAA1529_uc010msm.1_RNA	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				GGCTGATTGCCCGCATCGACA	0.572			NA											6	119					0	0	0.001168	0	0
GABBR2	9568	broad.mit.edu	37	9	101148007	101148007	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:101148007C>T	uc004ays.2	-	11	1733	c.1577G>A	c.(1576-1578)GGA>GAA	p.G526E		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	526	Helical; Name=2; (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GAGCATCCCTCCAAGGATGAT	0.393			NA											6	71					0	0	0.001168	0	0
COL15A1	1306	broad.mit.edu	37	9	101797356	101797356	+	Missense_Mutation	SNP	C	C	T	rs142089094	byFrequency	TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:101797356C>T	uc004azb.1	+	18	2346	c.2140C>T	c.(2140-2142)CCT>TCT	p.P714S		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	714	Triple-helical region 2 (COL2).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				AGCTGGCCCTCCTGGGGTCAT	0.612			NA											12	102					0	0	0.001855	0	0
TGFBR1	7046	broad.mit.edu	37	9	101907147	101907147	+	Silent	SNP	A	A	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:101907147A>G	uc004azc.2	+	6	1183	c.1107A>G	c.(1105-1107)CCA>CCG	p.P369P	TGFBR1_uc004azd.2_Silent_p.P292P|TGFBR1_uc011lvc.1_Silent_p.P300P	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	369	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				ATATTGCTCCAAACCACAGAG	0.343			NA											7	79					0	0	0.001984	0	0
ALDOB	229	broad.mit.edu	37	9	104189909	104189909	+	Nonsense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:104189909G>C	uc004bbk.2	-	5	477	c.395C>G	c.(394-396)TCA>TGA	p.S132*		NM_000035	NP_000026	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	132					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			skin(1)	1		Acute lymphoblastic leukemia(62;0.0559)				ACAGCGCTCTGAGAGGCCATC	0.512			NA											13	52					0	0	0.001855	0	0
ABCA1	19	broad.mit.edu	37	9	107589339	107589339	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:107589339C>T	uc004bcl.2	-	16	2540	c.2227G>A	c.(2227-2229)GCC>ACC	p.A743T		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	743					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCCAGGTTGGCTCTGGAGAAG	0.562			NA											15	65					0	0	0.004007	0	0
OR1N2	138882	broad.mit.edu	37	9	125315473	125315473	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:125315473T>A	uc011lyx.1	+	1	25	c.25T>A	c.(25-27)TCA>ACA	p.S9T		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						TCTGCGCAGATCACACGAACT	0.333			NA											34	92					0	0	0.002445	0	0
FIBCD1	84929	broad.mit.edu	37	9	133799190	133799190	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:133799190G>T	uc004bzz.2	-	4	1035	c.790C>A	c.(790-792)CAC>AAC	p.H264N	FIBCD1_uc011mcc.1_Missense_Mutation_p.H264N	NM_032843	NP_116232	Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	264	Fibrinogen C-terminal.|Extracellular (Potential).				signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding				0	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		GCCGGGTAGTGGGTGGGAAAG	0.687			NA											15	57					2.31682e-05	2.68465e-05	0.003163	1	0
LAMC3	10319	broad.mit.edu	37	9	133962991	133962991	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:133962991G>C	uc004caa.1	+	26	4457	c.4359G>C	c.(4357-4359)GAG>GAC	p.E1453D	LAMC3_uc010mze.1_Missense_Mutation_p.E141D	NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	1453	Domain II and I.|Potential.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		GCAGACAGGAGCTGGAGGAAG	0.662			NA											17	55					0	0	0.00499	0	0
C9orf171	389799	broad.mit.edu	37	9	135357700	135357700	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:135357700G>T	uc004cbn.2	+	2	247	c.199G>T	c.(199-201)GCC>TCC	p.A67S	C9orf171_uc004cbo.2_Intron	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	67										ovary(4)|large_intestine(1)	5						TTCGTAGGCTGCCGGCCCGGC	0.512			NA											21	68					1.2644e-06	1.54814e-06	0.010504	1	0
C9orf171	389799	broad.mit.edu	37	9	135374112	135374112	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:135374112T>A	uc004cbn.2	+	3	382	c.334T>A	c.(334-336)TAC>AAC	p.Y112N	C9orf171_uc004cbo.2_Missense_Mutation_p.Y76N	NM_207417	NP_997300	Q6ZQR2	CI171_HUMAN	hypothetical protein LOC389799	112										ovary(4)|large_intestine(1)	5						GGAAAGAAGCTACAGTCTGCC	0.547			NA											7	20					0	0	0.001984	0	0
SARDH	1757	broad.mit.edu	37	9	136582532	136582532	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:136582532C>A	uc004cep.3	-	8	1200	c.1066G>T	c.(1066-1068)GTG>TTG	p.V356L	SARDH_uc004ceo.2_Missense_Mutation_p.V356L|SARDH_uc011mdn.1_Missense_Mutation_p.V356L|SARDH_uc011mdo.1_Missense_Mutation_p.V188L	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	356					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGGTGAACACCTCCCAGTCC	0.597			NA											11	57					6.40141e-05	7.32707e-05	0.000978	1	0
EHMT1	79813	broad.mit.edu	37	9	140638453	140638453	+	Missense_Mutation	SNP	G	G	T	rs143891279		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr9:140638453G>T	uc011mfc.1	+	6	1118	c.1081G>T	c.(1081-1083)GGC>TGC	p.G361C	EHMT1_uc004coa.2_Missense_Mutation_p.G361C|EHMT1_uc004cob.1_Missense_Mutation_p.G330C	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	361					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GGAGGACGACGGCCATGGTGC	0.642			NA											15	57					0.000308642	0.00034145	0.003163	1	0
MXRA5	25878	broad.mit.edu	37	X	3235264	3235264	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:3235264G>T	uc004crg.3	-	6	6615	c.6458C>A	c.(6457-6459)CCG>CAG	p.P2153Q		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2153	Ig-like C2-type 6.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CGTCCTCCGCGGGGAGGTGCC	0.697			NA											3	22					0.00024832	0.000275802	0.009096	1	0
AMELX	265	broad.mit.edu	37	X	11316980	11316980	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:11316980C>G	uc004cut.2	+	5	525	c.457C>G	c.(457-459)CCG>GCG	p.P153A	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.P167A|AMELX_uc004cuu.2_Missense_Mutation_p.P137A	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	153					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						GCAGCCCCTGCCGCCACAGCC	0.657			NA											8	23					0	0	0.00308	0	0
MBTPS2	51360	broad.mit.edu	37	X	21887655	21887655	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:21887655G>A	uc004dae.2	+	7	1026	c.829G>A	c.(829-831)GAC>AAC	p.D277N	MBTPS2_uc010nfr.2_5'UTR|MBTPS2_uc004dab.2_Missense_Mutation_p.D277N	NM_015884	NP_056968	O43462	MBTP2_HUMAN	membrane-bound transcription factor peptidase,	277	Lumenal (Probable).				cholesterol metabolic process|proteolysis	Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity			ovary(1)	1						TTTTGTGGGAGACCTTGTCAC	0.428			NA											8	147					0	0	0.004482	0	0
DMD	1756	broad.mit.edu	37	X	32834589	32834589	+	Missense_Mutation	SNP	G	G	T	rs141028860		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:32834589G>T	uc004dda.1	-	6	770	c.526C>A	c.(526-528)CAT>AAT	p.H176N	DMD_uc004dcz.2_Missense_Mutation_p.H53N|DMD_uc004dcy.1_Missense_Mutation_p.H172N|DMD_uc004ddb.1_Missense_Mutation_p.H168N|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Missense_Mutation_p.H168N|DMD_uc010ngp.1_Missense_Mutation_p.H53N|DMD_uc010ngq.1_Intron|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	176	CH 2.|Actin-binding.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTTACCTATGACTATGGATG	0.403			NA											13	74					1.61879e-10	2.23528e-10	0.001368	1	0
FAM47A	158724	broad.mit.edu	37	X	34149137	34149137	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:34149137T>A	uc004ddg.2	-	1	1292	c.1259A>T	c.(1258-1260)CAG>CTG	p.Q420L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	420										ovary(4)|central_nervous_system(1)	5						ATTGGACACCTGACTAGTGTC	0.552			NA											4	60					0	0	0.009096	0	0
FAM47C	442444	broad.mit.edu	37	X	37028233	37028233	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:37028233C>A	uc004ddl.1	+	1	1764	c.1750C>A	c.(1750-1752)CCA>ACA	p.P584T		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	584										ovary(3)	3						CCATCTCTGCCCAGAGCCTCC	0.642			NA											12	88					6.94344e-10	9.49444e-10	0.006122	1	0
FAM47C	442444	broad.mit.edu	37	X	37028467	37028467	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:37028467C>A	uc004ddl.1	+	1	1998	c.1984C>A	c.(1984-1986)CGG>AGG	p.R662R		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	662										ovary(3)	3						TCCCAAGACTCGGGTGTCCAG	0.652			NA											17	70					8.34094e-07	1.02573e-06	0.008871	1	0
USP11	8237	broad.mit.edu	37	X	47107228	47107228	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:47107228G>A	uc004dhp.2	+	21	2791	c.2791G>A	c.(2791-2793)GAC>AAC	p.D931N	USP11_uc004dhq.2_Missense_Mutation_p.D657N	NM_004651	NP_004642	P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	931					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(1)|lung(1)|central_nervous_system(1)	3						CCAACGCCAGGACGTGGCGCG	0.622			NA											7	46					0	0	0.00308	0	0
HDAC6	10013	broad.mit.edu	37	X	48682427	48682427	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:48682427T>A	uc011mmi.1	+	27	3494	c.3399T>A	c.(3397-3399)TGT>TGA	p.C1133*	HDAC6_uc004dks.1_Nonsense_Mutation_p.C1133*|HDAC6_uc010nig.1_Nonsense_Mutation_p.C981*|HDAC6_uc004dkt.1_Nonsense_Mutation_p.C1133*|HDAC6_uc011mmk.1_Nonsense_Mutation_p.C1114*|HDAC6_uc004dkv.1_Nonsense_Mutation_p.C781*|HDAC6_uc004dkw.1_Nonsense_Mutation_p.C781*|HDAC6_uc004dkx.1_Nonsense_Mutation_p.C496*	NM_006044	NP_006035	Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	1133	UBP-type.	Zinc 3.			aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4					Vorinostat(DB02546)	CCCAACCTTGTGGGGACTGTG	0.562	Pancreas(112;205 1675 2305 8976 15959)		NA											7	41					0	0	0.00308	0	0
PQBP1	10084	broad.mit.edu	37	X	48759733	48759733	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:48759733G>C	uc004dle.2	+	5	705	c.516G>C	c.(514-516)GAG>GAC	p.E172D	PQBP1_uc004dlf.2_Missense_Mutation_p.E172D|PQBP1_uc004dlg.2_Missense_Mutation_p.E172D|PQBP1_uc004dld.2_Intron|PQBP1_uc004dlh.2_Missense_Mutation_p.E172D|PQBP1_uc004dli.2_Missense_Mutation_p.E172D|PQBP1_uc004dlj.1_Missense_Mutation_p.E172D|PQBP1_uc004dln.2_Missense_Mutation_p.E172D|PQBP1_uc010nih.2_RNA|PQBP1_uc010nii.2_Missense_Mutation_p.E130D|PQBP1_uc004dlk.2_Intron|PQBP1_uc004dll.2_Intron|PQBP1_uc004dlm.2_Missense_Mutation_p.E130D|PQBP1_uc010nij.2_Missense_Mutation_p.E72D	NM_001032382	NP_001027554	O60828	PQBP1_HUMAN	polyglutamine binding protein 1	172	Arg-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|transcription coactivator activity			large_intestine(1)	1						ACCGGGAAGAGGGCAAAGAAC	0.607			NA											12	24					0	0	0.001368	0	0
CCNB3	85417	broad.mit.edu	37	X	50053795	50053795	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:50053795C>G	uc004dox.3	+	6	2924	c.2626C>G	c.(2626-2628)CGA>GGA	p.R876G	CCNB3_uc004doy.2_Missense_Mutation_p.R876G|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	876					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					CCTCTTTAAGCGACACTCAGC	0.517			NA											7	51					0	0	0.001984	0	0
TSPYL2	64061	broad.mit.edu	37	X	53115108	53115108	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:53115108G>A	uc004drw.2	+	6	1666	c.1534G>A	c.(1534-1536)GAT>AAT	p.D512N	TSPYL2_uc004drv.2_3'UTR|TSPYL2_uc004drx.1_Missense_Mutation_p.D117N	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	512	Asn-rich.				cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0						tgagagtgcagatgacaacaa	0.095			NA											9	48					0	0	0.004482	0	0
PHF8	23133	broad.mit.edu	37	X	54012298	54012298	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:54012298G>T	uc004dsu.2	-	17	2261	c.2188C>A	c.(2188-2190)CTG>ATG	p.L730M	PHF8_uc004dst.2_Missense_Mutation_p.L694M|PHF8_uc004dsv.2_Missense_Mutation_p.L560M|PHF8_uc004dsw.2_Missense_Mutation_p.L593M|PHF8_uc004dsx.2_Missense_Mutation_p.L458M|PHF8_uc004dsy.2_Intron	NM_015107	NP_055922	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	730					brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(3)	3						GCCTTGAGCAGATCAAGAATG	0.552			NA											15	94					4.93089e-13	7.23541e-13	0.00245	1	0
OPHN1	4983	broad.mit.edu	37	X	67417059	67417059	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:67417059A>C	uc004dww.3	-	12	1367	c.1073T>G	c.(1072-1074)CTA>CGA	p.L358R	OPHN1_uc011mpg.1_Missense_Mutation_p.L358R	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	358	PH.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						TTCCATCCATAGCCTTCTGTT	0.473			NA											16	86					0	0	0.004007	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962484	73962484	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:73962484G>T	uc004eby.2	-	3	2525	c.1908C>A	c.(1906-1908)CAC>CAA	p.H636Q		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	636					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TTTGAATCCTGTGCCTGTTGC	0.403			NA											4	29					0.00024832	0.000275802	0.009096	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912693	77912693	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:77912693C>A	uc004edc.1	-	2	1521	c.1225G>T	c.(1225-1227)GGA>TGA	p.G409*		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	409							nucleic acid binding|zinc ion binding			ovary(1)	1						GGTCCATCTCCCTCTGCAGAG	0.527			NA											14	98					7.93312e-07	9.77722e-07	0.00245	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77913149	77913149	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:77913149G>T	uc004edc.1	-	2	1065	c.769C>A	c.(769-771)CAG>AAG	p.Q257K		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	257							nucleic acid binding|zinc ion binding			ovary(1)	1						CTATACAGCTGAACCAGGAAC	0.507			NA											9	16					2.17888e-05	2.53002e-05	0.006214	1	0
GPR174	84636	broad.mit.edu	37	X	78426624	78426624	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:78426624C>A	uc004edg.1	+	1	156	c.120C>A	c.(118-120)GCC>GCA	p.A40A		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	40	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						ATATATTAGCCCTGTGGGTAT	0.383			NA								HNSCC(63;0.18)			7	26					2.7689e-08	3.62732e-08	0.001984	1	0
GPR174	84636	broad.mit.edu	37	X	78426925	78426925	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:78426925G>T	uc004edg.1	+	1	457	c.421G>T	c.(421-423)GGC>TGC	p.G141C		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	141	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						CAGCATTGCTGGCTGGCTGAT	0.473			NA								HNSCC(63;0.18)			17	193					1.45105e-14	2.19809e-14	0.006122	1	0
KLHL4	56062	broad.mit.edu	37	X	86888896	86888896	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:86888896T>A	uc004efb.2	+	8	1879	c.1697T>A	c.(1696-1698)GTT>GAT	p.V566D	KLHL4_uc004efa.2_Missense_Mutation_p.V566D	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	566	Kelch 3.					cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						GTTGGTGTTGTTGCATTAAAC	0.423			NA											36	63					0	0	0.009718	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873455	91873455	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:91873455C>A	uc004efk.1	+	7	4405	c.3560C>A	c.(3559-3561)CCA>CAA	p.P1187Q	PCDH11X_uc004efl.1_Missense_Mutation_p.P1177Q|PCDH11X_uc004efo.1_Missense_Mutation_p.P1150Q|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.P1179Q|PCDH11X_uc004efn.1_Missense_Mutation_p.P1169Q	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1187	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CACCACAGCCCACGAGTGACA	0.587	NSCLC(38;925 1092 2571 38200 45895)		NA											55	111					6.4308e-24	1.06297e-23	0.00361	1	0
CENPI	2491	broad.mit.edu	37	X	100403107	100403107	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:100403107A>T	uc004egx.2	+	19	2321	c.2051A>T	c.(2050-2052)CAT>CTT	p.H684L	CENPI_uc011mrg.1_Missense_Mutation_p.H684L	NM_006733	NP_006724	Q92674	CENPI_HUMAN	centromere protein I	684					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			skin(1)	1						AATGTAGTCCATCATCCTTCT	0.353			NA											6	204					0	0	0.00308	0	0
ZMAT1	84460	broad.mit.edu	37	X	101152922	101152922	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:101152922C>T	uc011mrl.1	-	5	735	c.424G>A	c.(424-426)GGA>AGA	p.G142R	ZMAT1_uc004ein.2_5'UTR|ZMAT1_uc011mrm.1_5'UTR	NM_001011657	NP_001011657	Q5H9K5	ZMAT1_HUMAN	zinc finger, matrin type 1 isoform 1	Error:Variant_position_missing_in_A7MD47_after_alignment						nucleus	zinc ion binding			ovary(1)	1						TGGACCTTTCCCACATAGTGA	0.413			NA											21	97					0	0	0.001882	0	0
GPRASP1	9737	broad.mit.edu	37	X	101912716	101912716	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:101912716C>A	uc004ejj.3	+	5	4676	c.3875C>A	c.(3874-3876)ACA>AAA	p.T1292K	GPRASP1_uc004eji.3_Missense_Mutation_p.T1292K|GPRASP1_uc010nod.2_Missense_Mutation_p.T1292K	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1292	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						AATGCCAAAACAAGGTTTCAT	0.378			NA											7	107					1.6384e-10	2.25682e-10	0.001984	1	0
CLDN2	9075	broad.mit.edu	37	X	106171887	106171887	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:106171887C>A	uc004emq.1	+	2	948	c.429C>A	c.(427-429)ATC>ATA	p.I143I	MORC4_uc004emp.3_Intron|CLDN2_uc004emt.1_Silent_p.I143I	NM_020384	NP_065117	P57739	CLD2_HUMAN	claudin 2	143	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1						TTCATGGGATCCTACGGGACT	0.498			NA											34	234					1.22384e-17	1.89475e-17	0.002836	1	0
IRS4	8471	broad.mit.edu	37	X	107976663	107976663	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:107976663G>A	uc004eoc.2	-	1	2945	c.2912C>T	c.(2911-2913)CCA>CTA	p.P971L		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	971						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity	p.P971L(1)		ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GTCGTTTGCTGGATTTGGAAA	0.483			NA											28	268					0	0	0.00632	0	0
ALG13	79868	broad.mit.edu	37	X	110987964	110987964	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:110987964C>A	uc011msy.1	+	24	2798	c.2764C>A	c.(2764-2766)CCA>ACA	p.P922T	ALG13_uc011msx.1_Intron|ALG13_uc011msz.1_Missense_Mutation_p.P844T|ALG13_uc011mta.1_Intron|ALG13_uc011mtb.1_Intron			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	922	Pro-rich.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						accaccaccaccaccaccacc	0.234			NA											3	7					0.004672	0.00497285	0.004672	1	0
TRPC5	7224	broad.mit.edu	37	X	111195495	111195495	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:111195495G>A	uc004epl.1	-	2	1073	c.154C>T	c.(154-156)CTT>TTT	p.L52F	TRPC5_uc004epm.1_Missense_Mutation_p.L52F	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	52	Cytoplasmic (Potential).|ANK 1.				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						GCCTCCTGAAGGGCCTGCTTC	0.542			NA											9	130					0	0	0.006214	0	0
LRCH2	57631	broad.mit.edu	37	X	114422812	114422812	+	Silent	SNP	C	C	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:114422812C>T	uc010nqe.2	-	2	502	c.471G>A	c.(469-471)CAG>CAA	p.Q157Q	LRCH2_uc004epz.2_Silent_p.Q157Q|RBMXL3_uc011mte.1_5'Flank	NM_020871	NP_065922	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH)	157										ovary(1)	1						ATGTTAACATCTGCAGATTTT	0.289			NA											4	15					0	0	0.009096	0	0
DOCK11	139818	broad.mit.edu	37	X	117677516	117677516	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:117677516A>T	uc004eqp.2	+	4	415	c.352A>T	c.(352-354)AAG>TAG	p.K118*		NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	118	Interaction with activated CDC42 (By similarity).				blood coagulation	cytosol	GTP binding			ovary(3)	3						GGTAAACTACAAGTATGAGGA	0.353			NA											28	130					0	0	0.008361	0	0
DOCK11	139818	broad.mit.edu	37	X	117742200	117742200	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:117742200T>A	uc004eqp.2	+	26	2821	c.2758T>A	c.(2758-2760)TTC>ATC	p.F920I	DOCK11_uc004eqq.2_Missense_Mutation_p.F686I	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	920					blood coagulation	cytosol	GTP binding			ovary(3)	3						GTAGTATAGCTTCCGACCTGA	0.358			NA											9	129					0	0	0.008291	0	0
ODZ1	10178	broad.mit.edu	37	X	123615651	123615651	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:123615651G>A	uc004euj.2	-	21	3923	c.3859C>T	c.(3859-3861)CTT>TTT	p.L1287F	ODZ1_uc011muj.1_Missense_Mutation_p.L1293F|ODZ1_uc010nqy.2_Missense_Mutation_p.L1294F	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1287	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TCAAAGGGAAGGCACTGATCA	0.408			NA											10	165					0	0	0.000978	0	0
ODZ1	10178	broad.mit.edu	37	X	124097540	124097540	+	Silent	SNP	T	T	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:124097540T>C	uc004euj.2	-	1	127	c.63A>G	c.(61-63)CTA>CTG	p.L21L	ODZ1_uc011muj.1_Silent_p.L21L|ODZ1_uc010nqy.2_Silent_p.L21L	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	21	Teneurin N-terminal.|Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGGTGTAAGCTAGATCCATTT	0.443			NA											42	339					0	0	0.009718	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298847	125298847	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:125298847C>A	uc004euk.1	-	1	1088	c.1061G>T	c.(1060-1062)CGG>CTG	p.R354L		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	354	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCTCAGCGACCGCACGCCTGT	0.637			NA											43	85					1.57945e-13	2.33593e-13	0.002852	1	0
XPNPEP2	7512	broad.mit.edu	37	X	128901653	128901653	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:128901653G>A	uc004eut.1	+	20	2059	c.1815G>A	c.(1813-1815)CTG>CTA	p.L605L		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	605					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						ATGTCAGCCTGCTGTCTCCCG	0.587			NA											6	173					0	0	0.001984	0	0
UTP14A	10813	broad.mit.edu	37	X	129054695	129054695	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:129054695G>A	uc004euz.2	+	10	949	c.921G>A	c.(919-921)AAG>AAA	p.K307K	UTP14A_uc011mup.1_Silent_p.K255K|UTP14A_uc011muq.1_Silent_p.K253K|UTP14A_uc004eva.1_Silent_p.K13K	NM_006649	NP_006640	Q9BVJ6	UT14A_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein,	307					rRNA processing	nucleolus|small-subunit processome	protein binding			ovary(2)	2						AATGGGCCAAGTCAAAGGCAA	0.458			NA											13	166					0	0	0.00245	0	0
ENOX2	10495	broad.mit.edu	37	X	129771317	129771317	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:129771317G>T	uc004evw.2	-	12	1702	c.1284C>A	c.(1282-1284)TAC>TAA	p.Y428*	ENOX2_uc004evx.2_Nonsense_Mutation_p.Y399*|ENOX2_uc004evy.2_Nonsense_Mutation_p.Y399*|ENOX2_uc004evv.2_Nonsense_Mutation_p.Y253*	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	428	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						CTTCATTCCGGTAGGCATCGA	0.443	Ovarian(101;828 1506 2951 9500 35258)		NA											37	299					1.57351e-24	2.63189e-24	0.003755	1	0
USP26	83844	broad.mit.edu	37	X	132162134	132162134	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:132162134C>A	uc010nrm.1	-	6	585	c.115G>T	c.(115-117)GTG>TTG	p.V39L	USP26_uc011mvf.1_Missense_Mutation_p.V39L	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	39					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					AAATACAGCACCAGTCTATCT	0.368	NSCLC(104;342 1621 36940 47097 52632)		NA											18	132					1.99824e-07	2.5465e-07	0.00499	1	0
GPC4	2239	broad.mit.edu	37	X	132548853	132548853	+	Silent	SNP	G	G	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:132548853G>A	uc004exc.1	-	1	353	c.141C>T	c.(139-141)GCC>GCT	p.A47A	GPC4_uc011mvg.1_5'Flank	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	47					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CGTGGAGGGGGGCATCGTTCT	0.637			NA											13	188					0	0	0.003163	0	0
GPR112	139378	broad.mit.edu	37	X	135430448	135430448	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:135430448T>A	uc004ezu.1	+	6	4874	c.4583T>A	c.(4582-4584)GTT>GAT	p.V1528D	GPR112_uc010nsb.1_Missense_Mutation_p.V1323D|GPR112_uc010nsc.1_Missense_Mutation_p.V1295D	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1528	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TCCAAAAAAGTTTCTGACACT	0.433			NA											10	195					0	0	0.006214	0	0
GPR112	139378	broad.mit.edu	37	X	135430861	135430861	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:135430861G>T	uc004ezu.1	+	6	5287	c.4996G>T	c.(4996-4998)GGG>TGG	p.G1666W	GPR112_uc010nsb.1_Missense_Mutation_p.G1461W|GPR112_uc010nsc.1_Missense_Mutation_p.G1433W	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	1666	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					CATTATGGCTGGGATAGTGAC	0.473			NA											45	345					1.32667e-27	2.25253e-27	0.00361	1	0
GPR112	139378	broad.mit.edu	37	X	135445641	135445641	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:135445641T>A	uc004ezu.1	+	13	7574	c.7283T>A	c.(7282-7284)ATC>AAC	p.I2428N	GPR112_uc010nsb.1_Missense_Mutation_p.I2223N	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2428	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TTCAGTTCAATCAGCATCAAC	0.403			NA											14	109					0	0	0.003163	0	0
HAUS7	55559	broad.mit.edu	37	X	152734677	152734677	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:152734677G>T	uc004fho.1	-	2	739	c.181C>A	c.(181-183)CCA>ACA	p.P61T	HAUS7_uc004fhl.2_RNA|HAUS7_uc004fhm.2_RNA|HAUS7_uc004fhn.1_Missense_Mutation_p.P61T|HAUS7_uc004fhp.1_RNA|HAUS7_uc011myq.1_RNA	NM_017518	NP_059988	Q99871	HAUS7_HUMAN	HAUS augmin-like complex subunit 7	61					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding				0						ATTGTCTTTGGCTCTGTGATA	0.473			NA											18	167					2.35188e-11	3.321e-11	0.006122	1	0
BGN	633	broad.mit.edu	37	X	152770113	152770114	+	Missense_Mutation	DNP	GT	GT	TA			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:152770113_152770114GT>TA	uc004fhr.1	+	2	196_197	c.24_25GT>TA	c.(22-27)GTGTCT>GTTACT	p.S9T	BGN_uc004fhq.1_RNA	NM_001711	NP_001702	P21810	PGS1_HUMAN	biglycan preproprotein	9						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGCGCCTCGTGTCTCTGCTGGC	0.629			NA											24	42					0	0	0.004672	0	0
ATP2B3	492	broad.mit.edu	37	X	152806953	152806953	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:152806953G>T	uc004fht.1	+	2	471	c.345G>T	c.(343-345)GAG>GAT	p.E115D	ATP2B3_uc004fhs.1_Missense_Mutation_p.E115D	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	115	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCATCCTGGAGGTGGCTGCCA	0.622			NA											20	45					2.89027e-11	4.04062e-11	0.002299	1	0
IDH3G	3421	broad.mit.edu	37	X	153051701	153051701	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153051701C>A	uc004fip.2	-	12	1232	c.1046G>T	c.(1045-1047)CGT>CTT	p.R349L	IDH3G_uc004fio.2_Missense_Mutation_p.R291L|IDH3G_uc004fiq.2_Missense_Mutation_p.R349L|IDH3G_uc010num.2_Missense_Mutation_p.R291L|IDH3G_uc004fir.2_Missense_Mutation_p.R291L|IDH3G_uc004fit.1_3'UTR|IDH3G_uc004fis.2_Missense_Mutation_p.R291L|IDH3G_uc004fiu.2_Missense_Mutation_p.R125L	NM_004135	NP_004126	P51553	IDH3G_HUMAN	isocitrate dehydrogenase 3 (NAD+) gamma isoform	349					carbohydrate metabolic process|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleolus	ATP binding|isocitrate dehydrogenase (NAD+) activity|magnesium ion binding|NAD binding				0	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	GACAGCCTTACGGATGGAGGT	0.662			NA											14	130					0.000308642	0.00034145	0.003163	1	0
L1CAM	3897	broad.mit.edu	37	X	153128312	153128312	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153128312A>T	uc004fjb.2	-	28	3688	c.3580T>A	c.(3580-3582)TCG>ACG	p.S1194T	L1CAM_uc004fjc.2_Missense_Mutation_p.S1190T|L1CAM_uc010nuo.2_Missense_Mutation_p.S1185T	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	1194	Cytoplasmic (Potential).		S -> L (in HSAS and MASA).		axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCGTTGAGCGATGGCTGGCTG	0.622			NA											8	49					0	0	0.00308	0	0
L1CAM	3897	broad.mit.edu	37	X	153130448	153130448	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153130448C>A	uc004fjb.2	-	22	2982	c.2874G>T	c.(2872-2874)CTG>CTT	p.L958L	L1CAM_uc004fjc.2_Silent_p.L958L|L1CAM_uc010nuo.2_Silent_p.L953L	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	958	Extracellular (Potential).|Fibronectin type-III 4.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCCTCATCCACTGTGGGGA	0.682			NA											9	157					3.09899e-07	3.93144e-07	0.004482	1	0
L1CAM	3897	broad.mit.edu	37	X	153132929	153132929	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153132929G>T	uc004fjb.2	-	16	2127	c.2019C>A	c.(2017-2019)ACC>ACA	p.T673T	L1CAM_uc004fjc.2_Silent_p.T673T|L1CAM_uc010nuo.2_Silent_p.T668T	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	673	Fibronectin type-III 1.|Extracellular (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGTGGTAGAGGTCTGGTTCC	0.512			NA											24	261					3.6726e-16	5.62398e-16	0.003954	1	0
L1CAM	3897	broad.mit.edu	37	X	153136381	153136381	+	Silent	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153136381C>A	uc004fjb.2	-	6	666	c.558G>T	c.(556-558)ACG>ACT	p.T186T	L1CAM_uc004fjc.2_Silent_p.T186T|L1CAM_uc010nuo.2_Silent_p.T181T|L1CAM_uc004fjd.1_5'UTR|L1CAM_uc004fje.1_Silent_p.T181T	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	186	Extracellular (Potential).|Ig-like C2-type 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCTGGCCCATCGTCACCCGCT	0.602			NA											19	145					7.45023e-12	1.06812e-11	0.010504	1	0
OPN1LW	5956	broad.mit.edu	37	X	153420135	153420135	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153420135T>A	uc004fjz.3	+	4	698	c.665T>A	c.(664-666)GTC>GAC	p.V222D		NM_020061	NP_064445	P04000	OPSR_HUMAN	opsin 1 (cone pigments), long-wave-sensitive	222	Helical; Name=5; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TACATGATTGTCCTCATGGTC	0.602			NA											18	311					0	0	0.008871	0	0
FAM50A	9130	broad.mit.edu	37	X	153678642	153678642	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:153678642C>A	uc004fll.3	+	12	1084	c.986C>A	c.(985-987)CCT>CAT	p.P329H		NM_004699	NP_004690	Q14320	FA50A_HUMAN	XAP-5 protein	329					spermatogenesis	nucleus				ovary(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCTACGACCCTGAAAAGAAG	0.612			NA											13	98					9.31168e-06	1.10404e-05	0.001855	1	0
MPP1	4354	broad.mit.edu	37	X	154014665	154014665	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:154014665C>A	uc004fmp.1	-	6	606	c.491G>T	c.(490-492)AGA>ATA	p.R164I	MPP1_uc010nvg.1_Intron|MPP1_uc011mzv.1_Missense_Mutation_p.R134I|MPP1_uc004fmq.1_Missense_Mutation_p.R118I|MPP1_uc011mzw.1_Missense_Mutation_p.R147I|MPP1_uc010nvh.1_Missense_Mutation_p.R38I	NM_002436	NP_002427	Q00013	EM55_HUMAN	palmitoylated membrane protein 1	164	SH3.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			ovary(2)|central_nervous_system(1)	3	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AAACTGCGCTCTCATGAACAT	0.463			NA											27	543					4.87955e-14	7.31283e-14	0.005443	1	0
F8	2157	broad.mit.edu	37	X	154157322	154157322	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:154157322C>A	uc004fmt.2	-	14	4914	c.4743G>T	c.(4741-4743)TTG>TTT	p.L1581F		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1581	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CAAGAGGATCCAATAGCTTGG	0.433			NA											161	240					4.58859e-59	8.00866e-59	0.00361	1	0
RAB39B	116442	broad.mit.edu	37	X	154493532	154493532	+	Silent	SNP	G	G	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:154493532G>T	uc004fne.2	-	1	321	c.42C>A	c.(40-42)ATC>ATA	p.I14I		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	14					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGAATCCCCGATGACAATGA	0.667			NA											10	172					1.08611e-07	1.39678e-07	0.000978	1	0
RAB39B	116442	broad.mit.edu	37	X	154493561	154493561	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:154493561A>T	uc004fne.2	-	1	292	c.13T>A	c.(13-15)TGG>AGG	p.W5R		NM_171998	NP_741995	Q96DA2	RB39B_HUMAN	RAB39B, member RAS oncogene family	5					protein transport|small GTPase mediated signal transduction|synapse organization|vesicle-mediated transport	Golgi apparatus|plasma membrane	GTP binding				0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGTACAGCCAGATGGCCTCC	0.687			NA											7	135					0	0	0.006214	0	0
SPSB1	80176	broad.mit.edu	37	1	9416498	9416499	+	Frame_Shift_Ins	INS	-	-	G			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:9416498_9416499insG	uc010oae.1	+	2	887_888	c.548_549insG	c.(547-549)ATGfs	p.M183fs	SPSB1_uc001apv.2_Frame_Shift_Ins_p.M183fs	NM_025106	NP_079382	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box	183	B30.2/SPRY.				intracellular signal transduction	cytoplasm					0	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		GCCCTGGACATGGACGACGGGA	0.515			NA											25	181	---	---	---	---	NA	NA	NA	NA	NA
ESRRG	2104	broad.mit.edu	37	1	216850615	216850615	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:216850615delC	uc001hkw.1	-	2	441	c.275delG	c.(274-276)GGAfs	p.G92fs	ESRRG_uc001hky.1_Frame_Shift_Del_p.G69fs|ESRRG_uc009xdp.1_Frame_Shift_Del_p.G69fs|ESRRG_uc001hkz.1_Frame_Shift_Del_p.G69fs|ESRRG_uc010puc.1_Frame_Shift_Del_p.G69fs|ESRRG_uc001hla.1_Frame_Shift_Del_p.G69fs|ESRRG_uc001hlb.1_Frame_Shift_Del_p.G69fs|ESRRG_uc010pud.1_Intron|ESRRG_uc001hlc.1_Frame_Shift_Del_p.G69fs|ESRRG_uc001hld.1_Frame_Shift_Del_p.G69fs|ESRRG_uc001hkx.1_Frame_Shift_Del_p.G97fs|ESRRG_uc009xdo.1_Frame_Shift_Del_p.G69fs|ESRRG_uc001hle.1_Frame_Shift_Del_p.G69fs	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	92					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	CCCACTACCTCCCAGGATAGG	0.532			NA											68	157	---	---	---	---	NA	NA	NA	NA	NA
LYST	1130	broad.mit.edu	37	1	235922575	235922575	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr1:235922575delC	uc001hxj.2	-	23	6753	c.6578delG	c.(6577-6579)GGAfs	p.G2193fs	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2193					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCCCAGCACTCCCTTTGGGAC	0.512			NA							Chediak-Higashsyndrome				69	176	---	---	---	---	NA	NA	NA	NA	NA
IQSEC3	440073	broad.mit.edu	37	12	247477	247478	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:247477_247478delGC	uc001qhw.1	+	1	45_46	c.39_40delGC	c.(37-42)CGGCGCfs	p.R13fs	IQSEC3_uc001qhu.1_Frame_Shift_Del_p.R13fs|IQSEC3_uc001qht.1_Frame_Shift_Del_p.R98fs|uc001qhv.1_RNA	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	316_317	IQ.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGGTGTCCCGGCGCGCCGCTTG	0.599			NA											8	33	---	---	---	---	NA	NA	NA	NA	NA
MGA	23269	broad.mit.edu	37	15	42028569	42028569	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:42028569delG	uc010ucy.1	+	13	4288	c.4107delG	c.(4105-4107)GTGfs	p.V1369fs	MGA_uc010ucz.1_Frame_Shift_Del_p.V1369fs|MGA_uc010uda.1_Intron	NM_001164273	NP_001157745	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 1	1369						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CACTTAAGGTGGGCAGCTTCA	0.458			NA											40	89	---	---	---	---	NA	NA	NA	NA	NA
SIN3A	25942	broad.mit.edu	37	15	75715034	75715034	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr15:75715034delG	uc002bai.2	-	3	579	c.320delC	c.(319-321)CCAfs	p.P107fs	SIN3A_uc002baj.2_Frame_Shift_Del_p.P107fs|SIN3A_uc010uml.1_Frame_Shift_Del_p.P107fs|SIN3A_uc002bak.3_Frame_Shift_Del_p.P107fs	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	107					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TGCAACTGGTGGGGCTGGATG	0.527			NA											43	96	---	---	---	---	NA	NA	NA	NA	NA
SLC7A9	11136	broad.mit.edu	37	19	33355102	33355103	+	Frame_Shift_Ins	INS	-	-	C			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:33355102_33355103insC	uc002ntv.3	-	4	494_495	c.377_378insG	c.(376-378)GCCfs	p.A126fs	SLC7A9_uc002ntt.3_RNA|SLC7A9_uc002ntu.3_Frame_Shift_Ins_p.A126fs|SLC7A9_uc002ntw.3_5'UTR	NM_001126335	NP_001119807	P82251	BAT1_HUMAN	solute carrier family 7, member 9	126	Extracellular (Potential).		A -> T (in CSNU).		blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			skin(1)	1	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	GGCAGATGATGGCGAAGGACGT	0.599	GBM(181;1335 2108 9644 44178 46689)		NA											7	49	---	---	---	---	NA	NA	NA	NA	NA
ZIM2	23619	broad.mit.edu	37	19	57286803	57286804	+	Frame_Shift_Ins	INS	-	-	A	rs149106731		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr19:57286803_57286804insA	uc002qnr.2	-	11	1218_1219	c.836_837insT	c.(835-837)CCGfs	p.P279fs	uc010ygp.1_Intron|uc002qnp.1_Intron|ZIM2_uc010ygq.1_Frame_Shift_Ins_p.P75fs|ZIM2_uc010ygr.1_Frame_Shift_Ins_p.P75fs|ZIM2_uc002qnq.2_Frame_Shift_Ins_p.P279fs|ZIM2_uc010etp.2_Frame_Shift_Ins_p.P279fs|ZIM2_uc010ygs.1_Frame_Shift_Ins_p.P279fs	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AGCTTCTTTCCGGAGTGAGGGT	0.46			NA											41	125	---	---	---	---	NA	NA	NA	NA	NA
NPFFR2	10886	broad.mit.edu	37	4	72897699	72897699	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr4:72897699delG	uc003hgg.2	+	1	179	c.81delG	c.(79-81)GCGfs	p.A27fs	NPFFR2_uc010iig.1_5'UTR	NM_004885	NP_004876	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2 isoform 1	27	Extracellular (Potential).				detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			ACAAGGAGGCGGGGAGGGAGC	0.672			NA											7	84	---	---	---	---	NA	NA	NA	NA	NA
LMTK2	22853	broad.mit.edu	37	7	97800896	97800896	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:97800896delG	uc003upd.1	+	7	994	c.701delG	c.(700-702)CGGfs	p.R234fs		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	234	Protein kinase.				early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R234L(1)		lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GAGCACATGCGGGGGGACTCA	0.617			NA											25	104	---	---	---	---	NA	NA	NA	NA	NA
SERPINE1	5054	broad.mit.edu	37	7	100773778	100773779	+	Frame_Shift_Del	DEL	CA	CA	-	rs149070955		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr7:100773778_100773779delCA	uc003uxt.2	+	3	496_497	c.348_349delCA	c.(346-351)ACCACAfs	p.T116fs	SERPINE1_uc011kkj.1_Frame_Shift_Del_p.T101fs|SERPINE1_uc003uxu.1_5'Flank	NM_000602	NP_000593	P05121	PAI1_HUMAN	plasminogen activator inhibitor-1 isoform 1	116_117					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)|central_nervous_system(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	AGATCAGCACCACAGACGCGAT	0.599			NA											110	207	---	---	---	---	NA	NA	NA	NA	NA
ADCY8	114	broad.mit.edu	37	8	131848677	131848677	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr8:131848677delC	uc003ytd.3	-	12	2777	c.2521delG	c.(2521-2523)GTGfs	p.V841fs	ADCY8_uc010mds.2_Frame_Shift_Del_p.V710fs	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	841	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ATGGCCAACACCCCCGTGAAG	0.532			NA								HNSCC(32;0.087)			7	61	---	---	---	---	NA	NA	NA	NA	NA
SLITRK2	84631	broad.mit.edu	37	X	144904509	144904509	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chrX:144904509delG	uc004fcd.2	+	5	1556	c.566delG	c.(565-567)AGGfs	p.R189fs	SLITRK2_uc010nsp.2_Frame_Shift_Del_p.R189fs|SLITRK2_uc010nso.2_Frame_Shift_Del_p.R189fs|SLITRK2_uc011mwq.1_Frame_Shift_Del_p.R189fs|SLITRK2_uc011mwr.1_Frame_Shift_Del_p.R189fs|SLITRK2_uc011mws.1_Frame_Shift_Del_p.R189fs|SLITRK2_uc004fcg.2_Frame_Shift_Del_p.R189fs|SLITRK2_uc011mwt.1_Frame_Shift_Del_p.R189fs	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	189	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TTAGACCTCAGGGGGAATAGG	0.463			NA											27	210	---	---	---	---	NA	NA	NA	NA	NA
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-05-4405-01A-21D-1855-08	TCGA-05-4405-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	3ef10eb8-d713-4fda-9e03-bc594b356d77	78d03ee6-4bd7-427a-8b57-ed7d0877f545	g.chr12:25398285C>A	uc001rgp.1	-	2	215	c.34G>T	c.(34-36)GGT>TGT	p.G12C	KRAS_uc001rgq.1_Missense_Mutation_p.G12C|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12G(6)|p.G12N(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12C(CALU1_LUNG)|G12C(NCIH2030_LUNG)|G12C(LU99_LUNG)|G12C(NCIH1792_LUNG)|G12R(KP2_PANCREAS)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(NCIH2122_LUNG)|G12C(NCIH358_LUNG)|G12R(PSN1_PANCREAS)|G12C(KYSE410_OESOPHAGUS)|G12S(A549_LUNG)|G12R(HUPT3_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12C(HCC44_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(SW1463_LARGE_INTESTINE)|G12C(NCIH23_LUNG)|G12C(LU65_LUNG)|G12C(NCIH1373_LUNG)|G12C(MIAPACA2_PANCREAS)|G12R(HS274T_BREAST)|G12S(LS123_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(OV56_OVARY)|G12C(IALM_LUNG)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	12	NA	NA	NA	NA	0.184627	0.188656	0.000602	1	1