Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIIP	60672	broad.mit.edu	37	1	12089847	12089847	+	Silent	SNP	G	G	T	rs138345116		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:12089847G>T	uc001ato.1	+	7	921	c.741G>T	c.(739-741)CGG>CGT	p.R247R		NM_021933	NP_068752	Q5JXC2	MIIP_HUMAN	invasion inhibitory protein 45	247	Interaction with IGFBP2.									ovary(1)	1						GTGTCAACCGGCGCCTGTTCC	0.697			NA											3	28					6.4e-05	8.97834e-05	0.004672	1	0
PRAMEF12	390999	broad.mit.edu	37	1	12837707	12837707	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:12837707C>A	uc001aui.2	+	3	1444	c.1417C>A	c.(1417-1419)CTG>ATG	p.L473M		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	473										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTCACTGTCTGTTGAATGC	0.507			NA											11	98					0.00010058	0.000136701	0.001368	1	0
PRAMEF13	400736	broad.mit.edu	37	1	13448266	13448266	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:13448266C>A	uc010obi.1	-	4	1312	c.1209G>T	c.(1207-1209)GGG>GGT	p.G403G	PRAMEF14_uc009vnt.1_Silent_p.G355G	NM_001024661	NP_001019832	Q5VWM6	PRA13_HUMAN	PRAME family member 13	403											0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;9.86e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|COAD - Colon adenocarcinoma(227;0.000502)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		ACTTGCTCAGCCCACTGGTGT	0.557			NA											9	136					1.76689e-08	3.19204e-08	0.006214	1	0
C1orf94	84970	broad.mit.edu	37	1	34663388	34663388	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:34663388C>A	uc001bxs.3	+	2	712	c.313C>A	c.(313-315)CGA>AGA	p.R105R	C1orf94_uc001bxt.2_Silent_p.R295R	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	105							protein binding				0		Myeloproliferative disorder(586;0.0393)				GCTGCCTCCCCGACCTCCTCC	0.602			NA											4	78					0.000602214	0.000753197	0.000602	1	0
SF3A3	10946	broad.mit.edu	37	1	38435025	38435025	+	Splice_Site	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:38435025C>A	uc001cci.2	-	14	1405	c.1281_splice	c.e14+1	p.A427_splice	SF3A3_uc010oik.1_Splice_Site_p.A374_splice	NM_006802	NP_006793	Q12874	SF3A3_HUMAN	splicing factor 3a, subunit 3						nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nuclear speck	nucleic acid binding|protein binding|zinc ion binding				0	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GAATTCCTTACAGCAAAGTGT	0.448			NA											5	59					0.00116845	0.00143281	0.001168	1	0
PPAP2B	8613	broad.mit.edu	37	1	56989949	56989949	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:56989949C>A	uc001cyj.1	-	4	1076	c.575G>T	c.(574-576)AGG>ATG	p.R192M		NM_177414	NP_803133	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	192	Lumenal (Potential).				canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity				0						GGTGTCTCACCTGGCTTCCTG	0.403			NA											11	116					3.86212e-05	5.52271e-05	0.008291	1	0
LRRC7	57554	broad.mit.edu	37	1	70504491	70504491	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:70504491C>G	uc001dep.2	+	19	2900	c.2870C>G	c.(2869-2871)ACA>AGA	p.T957R	LRRC7_uc009wbg.2_Missense_Mutation_p.T241R|LRRC7_uc001deq.2_Missense_Mutation_p.T198R	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	957						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GACATTGGTACATATAAGGTG	0.403			NA											5	87					0	0	0.000602	0	0
GSTM5	2949	broad.mit.edu	37	1	110256125	110256125	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:110256125G>T	uc001dyn.2	+	4	268	c.197G>T	c.(196-198)GGG>GTG	p.G66V	GSTM5_uc010ovu.1_Missense_Mutation_p.G25V	NM_000851	NP_000842	P46439	GSTM5_HUMAN	glutathione S-transferase mu 5	66	GST N-terminal.				xenobiotic metabolic process	endoplasmic reticulum membrane	glutathione transferase activity			central_nervous_system(6)	6		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Colorectal(144;0.0131)|all cancers(265;0.0252)|Epithelial(280;0.0265)|Lung(183;0.0425)|COAD - Colon adenocarcinoma(174;0.0474)|LUSC - Lung squamous cell carcinoma(189;0.228)	Glutathione(DB00143)	TTGATTGATGGGGCTCACAAG	0.587			NA											7	166					0.00307968	0.00362461	0.00308	1	0
TBX15	6913	broad.mit.edu	37	1	119469162	119469162	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:119469162G>A	uc001ehl.1	-	3	489	c.174C>T	c.(172-174)GAC>GAT	p.D58D		NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	164	T-box.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CAGGCACAATGTCCATTGCTA	0.413			NA											5	79					0	0	0.000602	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767862	143767863	+	Translation_Start_Site	DNP	GG	GG	TT			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:143767862_143767863GG>TT	uc001ejt.2	-	1	19_20	c.-14_-13CC>AA	c.(-16--11)GCCCTG>GCAATG			NM_001123068	NP_001116540	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like						protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity				0						TGATAGTACAGGGCTCACAGCG	0.337			NA											16	148					0	0	0.004672	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145474697	145474697	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:145474697G>T	uc001enq.1	+	4	2662	c.1369G>T	c.(1369-1371)GGG>TGG	p.G457W	NBPF10_uc001emp.3_Intron|LIX1L_uc001enr.2_5'Flank	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	457	Pro-rich.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TCCTTATGCCGGGGCGCCAGG	0.642			NA											6	37					6.5536e-12	1.29596e-11	0.00308	1	0
SV2A	9900	broad.mit.edu	37	1	149885086	149885086	+	Silent	SNP	G	G	T	rs144624887		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:149885086G>T	uc001etg.2	-	2	798	c.307C>A	c.(307-309)CGG>AGG	p.R103R	SV2A_uc001eth.2_Silent_p.R103R	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	103	Cytoplasmic (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	GACTCTGCCCGGGGAATGCCC	0.632			NA											10	163					2.68362e-12	5.35504e-12	0.001368	1	0
PLEKHO1	51177	broad.mit.edu	37	1	150129601	150129601	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:150129601A>C	uc001ett.2	+	5	724	c.446A>C	c.(445-447)TAT>TCT	p.Y149S	PLEKHO1_uc001etr.2_5'UTR|PLEKHO1_uc001ets.2_Intron|PLEKHO1_uc001etu.2_5'UTR	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	149	Interaction with ATM, CKIP, IFP35 and NMI.|Interaction with capping proteins (CPs).					cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAGGACAGCTATCTTGCCCAT	0.542			NA											9	86					0	0	0.006214	0	0
GABPB2	126626	broad.mit.edu	37	1	151070440	151070440	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:151070440C>A	uc001ewr.2	+	5	915	c.584C>A	c.(583-585)GCA>GAA	p.A195E	GABPB2_uc010pcp.1_Missense_Mutation_p.A211E|GABPB2_uc001ews.2_Missense_Mutation_p.A155E|GABPB2_uc001ewt.2_Missense_Mutation_p.A94E	NM_144618	NP_653219	Q8TAK5	GABP2_HUMAN	GA repeat binding protein, beta 2	195					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding				0				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		GTTAACCTCGCAAGCCTTATT	0.413			NA											6	41					4.54149e-19	9.7731e-19	0.002299	1	0
FLG	2312	broad.mit.edu	37	1	152278647	152278647	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:152278647C>A	uc001ezu.1	-	3	8751	c.8715G>T	c.(8713-8715)GAG>GAT	p.E2905D		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2905	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGACCACCTCTCAGAGTCTT	0.567			NA							Ichthyosis				16	476					9.78306e-22	2.12612e-21	0.001786	1	0
FLG	2312	broad.mit.edu	37	1	152283455	152283455	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:152283455T>C	uc001ezu.1	-	3	3943	c.3907A>G	c.(3907-3909)AGA>GGA	p.R1303G	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1303	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			gagccatctcttgactgctcc	0.373			NA							Ichthyosis				16	340					0	0	0.00499	0	0
CRNN	49860	broad.mit.edu	37	1	152383311	152383311	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:152383311G>C	uc001ezx.2	-	3	321	c.247C>G	c.(247-249)CAG>GAG	p.Q83E		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	83	EF-hand.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAACAGGCCTGGGCAACTTTA	0.567			NA											33	209					0	0	0.002836	0	0
LCE1F	353137	broad.mit.edu	37	1	152748887	152748887	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:152748887C>A	uc010pdv.1	+	1	40	c.40C>A	c.(40-42)CCC>ACC	p.P14T		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	14	Pro-rich.				keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCAGCCccctcccaagtgcac	0.358			NA											5	57					1.26484e-09	2.35283e-09	0.00308	1	0
GATAD2B	57459	broad.mit.edu	37	1	153800615	153800615	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:153800615C>A	uc001fdb.3	-	2	453	c.209G>T	c.(208-210)AGT>ATT	p.S70I		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	70						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CTTGACACCACTGCCATCCTG	0.473			NA											15	287					4.14922e-12	8.24211e-12	0.004007	1	0
NUP210L	91181	broad.mit.edu	37	1	154112395	154112395	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:154112395G>A	uc001fdw.2	-	5	672	c.600C>T	c.(598-600)CCC>CCT	p.P200P	NUP210L_uc010peh.1_Silent_p.P200P	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	200						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TATATATTGGGGGAGCATATT	0.368			NA											27	554					0	0	0.005443	0	0
AQP10	89872	broad.mit.edu	37	1	154296832	154296832	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:154296832A>T	uc001feu.2	+	6	822	c.782A>T	c.(781-783)CAG>CTG	p.Q261L	AQP10_uc001fev.2_3'UTR|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	261	Extracellular (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCCACTTACCAGCTGTTGGTG	0.602			NA									OREG0013832	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	70					0	0	0.000978	0	0
PEAR1	375033	broad.mit.edu	37	1	156883518	156883518	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:156883518C>A	uc001fqj.1	+	21	2795	c.2679C>A	c.(2677-2679)AGC>AGA	p.S893R	PEAR1_uc001fqk.1_Missense_Mutation_p.S518R	NM_001080471	NP_001073940	Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	893	Pro-rich.					integral to membrane				ovary(2)|central_nervous_system(1)	3	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					ACAGCTATAGCTACAGCAATG	0.602			NA											9	49					4.3838e-07	7.28973e-07	0.001855	1	0
FCRL4	83417	broad.mit.edu	37	1	157556006	157556006	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:157556006T>G	uc001fqw.2	-	6	1223	c.1087A>C	c.(1087-1089)AAC>CAC	p.N363H	FCRL4_uc010phy.1_RNA	NM_031282	NP_112572	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4 precursor	363	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(2)|kidney(1)|skin(1)	4	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				CCGTAGCTGTTGTCTGCTGTA	0.502			NA											17	185					0	0	0.001523	0	0
CD1B	910	broad.mit.edu	37	1	158299700	158299700	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:158299700G>T	uc001frx.2	-	3	657	c.549C>A	c.(547-549)ACC>ACA	p.T183T	CD1B_uc001frw.2_Silent_p.T76T	NM_001764	NP_001755	P29016	CD1B_HUMAN	CD1B antigen precursor	183	Extracellular (Potential).				antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			ovary(2)	2	all_hematologic(112;0.0378)					ATCGGGGGCAGGTTTCATAGA	0.473			NA											11	236					6.40141e-05	8.97834e-05	0.000978	1	0
PYHIN1	149628	broad.mit.edu	37	1	158943507	158943507	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:158943507C>A	uc001ftb.2	+	8	1675	c.1430C>A	c.(1429-1431)CCT>CAT	p.P477H	PYHIN1_uc001ftc.2_Missense_Mutation_p.P468H|PYHIN1_uc001ftd.2_Intron|PYHIN1_uc001fte.2_Intron	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	477					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					ACTGTGGCCCCTCCTCTTTCT	0.438			NA											9	144					0.00448238	0.00523342	0.004482	1	0
FAM78B	149297	broad.mit.edu	37	1	166039567	166039567	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:166039567C>T	uc001gdr.2	-	3	1287	c.697G>A	c.(697-699)GCA>ACA	p.A233T	FAM78B_uc010plc.1_RNA|FAM78B_uc001gdq.2_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	233										central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					TTCACTAGTGCATTAGGGGGG	0.627			NA											5	138					0	0	0.000602	0	0
MPZL1	9019	broad.mit.edu	37	1	167745338	167745338	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:167745338G>T	uc001geo.2	+	5	845	c.643G>T	c.(643-645)GCT>TCT	p.A215S	MPZL1_uc001gep.2_Intron|MPZL1_uc001geq.2_Intron|MPZL1_uc009wvh.2_RNA	NM_003953	NP_003944	O95297	MPZL1_HUMAN	myelin protein zero-like 1 isoform a	215	Cytoplasmic (Potential).				cell-cell signaling|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	protein binding|structural molecule activity			ovary(2)	2	all_hematologic(923;0.215)					AGTTAAGCAGGCTCCTCGGAA	0.423			NA											5	59					3.59834e-05	5.19628e-05	0.001168	1	0
TBX19	9095	broad.mit.edu	37	1	168262493	168262493	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:168262493G>T	uc001gfl.2	+	3	631	c.580G>T	c.(580-582)GTG>TTG	p.V194L	TBX19_uc001gfj.3_Missense_Mutation_p.V125L	NM_005149	NP_005140	O60806	TBX19_HUMAN	T-box 19	194	T-box.				anatomical structure morphogenesis	nucleus	DNA binding				0	all_hematologic(923;0.215)					GTTCATAGCCGTGACTGCCTA	0.378			NA											3	40					6.4e-05	8.97834e-05	0.004672	1	0
HMCN1	83872	broad.mit.edu	37	1	185959439	185959439	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:185959439C>T	uc001grq.1	+	22	3470	c.3241C>T	c.(3241-3243)CTG>TTG	p.L1081L	HMCN1_uc001grr.1_Silent_p.L422L	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1081	Ig-like C2-type 8.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCAACGAGGACTGTCCCAGGA	0.428			NA											78	456					0	0	0.00361	0	0
LAX1	54900	broad.mit.edu	37	1	203743207	203743207	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:203743207G>T	uc001haa.2	+	5	1005	c.595G>T	c.(595-597)GCA>TCA	p.A199S	LAX1_uc010pql.1_Missense_Mutation_p.A183S|LAX1_uc001hab.2_Missense_Mutation_p.A123S	NM_017773	NP_060243	Q8IWV1	LAX1_HUMAN	lymphocyte transmembrane adaptor 1 isoform a	199	Cytoplasmic (Potential).				B cell activation|immune response|inactivation of MAPK activity|intracellular signal transduction|negative regulation of T cell activation	Golgi apparatus|integral to membrane|plasma membrane	protein kinase binding|SH2 domain binding			central_nervous_system(2)	2	all_cancers(21;0.0915)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTCCCCACAGCAGAAGAGAT	0.478			NA											12	119					1.08611e-07	1.85526e-07	0.000978	1	0
C1orf107	27042	broad.mit.edu	37	1	210015678	210015678	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:210015678G>T	uc001hhr.1	+	9	1630	c.1554G>T	c.(1552-1554)ATG>ATT	p.M518I	C1orf107_uc009xcu.1_Missense_Mutation_p.M233I	NM_014388	NP_055203	Q68CQ4	DIEXF_HUMAN	digestive-organ expansion factor homolog	518					multicellular organismal development	nucleus					0				OV - Ovarian serous cystadenocarcinoma(81;0.0367)		GAGTGCGGATGTGGAGCCTCA	0.448			NA											4	112					0.00024832	0.000326385	0.000248	1	0
SLC30A10	55532	broad.mit.edu	37	1	220100447	220100448	+	Splice_Site	DNP	CC	CC	AA			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:220100447_220100448CC>AA	uc001hlw.2	-	2	852	c.641_splice	c.e2-1	p.G214_splice	SLC30A10_uc001hlu.1_Splice_Site|SLC30A10_uc001hlx.2_5'UTR	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),						zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GAAGGAATCACCTGCATTCAAA	0.337	Colon(76;360 1614 43677 51136)		NA											20	123					0	0	0.004672	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232577115	232577115	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:232577115G>A	uc001hvg.2	-	12	3722	c.3564C>T	c.(3562-3564)TCC>TCT	p.S1188S	SIPA1L2_uc001hvf.2_Silent_p.S262S	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1188					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCAGGACTTTGGAAGGTGGGC	0.413			NA											25	419					0	0	0.004656	0	0
TARBP1	6894	broad.mit.edu	37	1	234565957	234565957	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:234565957G>A	uc001hwd.2	-	15	2485	c.2485C>T	c.(2485-2487)CAG>TAG	p.Q829*		NM_005646	NP_005637	Q13395	TARB1_HUMAN	TAR RNA binding protein 1	829					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			ovary(2)|skin(1)	3	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			GAGTCCAGCTGCAGCTCAGGC	0.552			NA											23	152					0	0	0.002299	0	0
RYR2	6262	broad.mit.edu	37	1	237947042	237947042	+	Silent	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:237947042G>C	uc001hyl.1	+	90	12150	c.12030G>C	c.(12028-12030)GTG>GTC	p.V4010V	RYR2_uc010pya.1_Silent_p.V425V	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4010					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCAACAACGTGGAGATGATTC	0.368			NA											3	39					0	0	0.004672	0	0
EXO1	9156	broad.mit.edu	37	1	242042514	242042514	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:242042514A>T	uc001hzh.2	+	13	2518	c.1978A>T	c.(1978-1980)AGT>TGT	p.S660C	EXO1_uc001hzi.2_Missense_Mutation_p.S660C|EXO1_uc001hzj.2_Missense_Mutation_p.S660C|EXO1_uc009xgq.2_Missense_Mutation_p.S659C	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	660	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			CGAGGAGTCCAGTGACGATGA	0.473			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					4	80					0	0	0.000248	0	0
SDCCAG8	10806	broad.mit.edu	37	1	243579109	243579109	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:243579109G>T	uc001hzw.2	+	14	1878	c.1722G>T	c.(1720-1722)ATG>ATT	p.M574I	SDCCAG8_uc010pyk.1_Missense_Mutation_p.M429I|SDCCAG8_uc010pyl.1_Missense_Mutation_p.M386I|SDCCAG8_uc001hzx.2_Intron	NM_006642	NP_006633	Q86SQ7	SDCG8_HUMAN	serologically defined colon cancer antigen 8	574	Mediates interaction with OFD1.|Gln-rich.|Potential.|Sufficient for homodimerization (By similarity).				establishment of cell polarity|G2/M transition of mitotic cell cycle|tube formation	cell-cell junction|centriole|cytosol	protein binding				0	all_cancers(71;0.000545)|all_epithelial(71;0.000509)|all_lung(81;0.0821)|Ovarian(71;0.0919)|all_neural(11;0.101)|Breast(184;0.218)	all_cancers(173;0.00395)	all cancers(7;1.58e-07)|GBM - Glioblastoma multiforme(7;5.12e-06)|OV - Ovarian serous cystadenocarcinoma(106;0.00392)	COAD - Colon adenocarcinoma(196;0.145)		TACAGCAAATGGAGGCCCAGC	0.507			NA											7	32					0.00198382	0.00237301	0.001984	1	0
OR1C1	26188	broad.mit.edu	37	1	247921475	247921475	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:247921475G>T	uc010pza.1	-	1	234	c.234C>A	c.(232-234)GTC>GTA	p.V78V		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	78	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CCATTTGGGGGACTGTAGTCG	0.453			NA											8	52					5.18039e-06	8.15123e-06	0.00308	1	0
OR2L8	391190	broad.mit.edu	37	1	248112412	248112412	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:248112412C>G	uc001idt.1	+	1	253	c.253C>G	c.(253-255)CTG>GTG	p.L85V	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			ATCTGATTTTCTGCATGGAAA	0.453			NA											73	520					0	0	0.00361	0	0
OR2L13	284521	broad.mit.edu	37	1	248263130	248263130	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:248263130G>T	uc001ids.2	+	3	790	c.453G>T	c.(451-453)GGG>GGT	p.G151G		NM_175911	NP_787107	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			GGACACTGGGGTCCATCAACT	0.488			NA											55	363					1.67886e-27	3.70361e-27	0.00361	1	0
OR2T6	254879	broad.mit.edu	37	1	248551546	248551546	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:248551546G>T	uc001iei.1	+	1	637	c.637G>T	c.(637-639)GTG>TTG	p.V213L		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCCCTTCTCGGTGGTGACTGC	0.532			NA											14	102					1.3612e-06	2.22144e-06	0.003163	1	0
C10orf18	54906	broad.mit.edu	37	10	5782212	5782212	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:5782212G>A	uc001iij.2	+	13	2704	c.2079G>A	c.(2077-2079)GGG>GGA	p.G693G	C10orf18_uc001iik.2_Intron	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	693										ovary(1)|central_nervous_system(1)	2						CCCCAGTGGGGAAAGTCATGC	0.532			NA											5	168					0	0	0.000602	0	0
PTF1A	256297	broad.mit.edu	37	10	23481584	23481584	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:23481584T>A	uc001irp.2	+	1	125	c.125T>A	c.(124-126)CTG>CAG	p.L42Q		NM_178161	NP_835455	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	42					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				pancreas(1)|skin(1)	2						GGCGATGAGCTGCTGGCGGAC	0.602			NA											4	39					0	0	0.000248	0	0
ABI1	10006	broad.mit.edu	37	10	27048010	27048010	+	Silent	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:27048010T>A	uc001isx.2	-	9	1226	c.1059A>T	c.(1057-1059)CCA>CCT	p.P353P	ABI1_uc001ite.2_Silent_p.P320P|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Silent_p.P326P|ABI1_uc001ita.2_Silent_p.P326P|ABI1_uc001isz.2_Silent_p.P321P|ABI1_uc001itb.2_Silent_p.P370P|ABI1_uc001itc.2_Silent_p.P325P|ABI1_uc010qdj.1_Intron|ABI1_uc001itd.2_Silent_p.P325P|ABI1_uc010qdk.1_Intron|ABI1_uc010qdg.1_Silent_p.P192P	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a	353	Pro-rich.				actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						GAGAATAAAGTGGACCTCCAT	0.418			NA											5	126					0	0	0.001168	0	0
RBP3	5949	broad.mit.edu	37	10	48389044	48389044	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:48389044C>G	uc001jez.2	-	1	1948	c.1834G>C	c.(1834-1836)GTG>CTG	p.V612L		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	612	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GCATCGGGCACCACTCCACCA	0.672			NA											4	52					0	0	0.000602	0	0
GDF2	2658	broad.mit.edu	37	10	48414372	48414372	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:48414372G>A	uc001jfa.1	-	2	659	c.496C>T	c.(496-498)CTG>TTG	p.L166L		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	166					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(2)|skin(1)	3						CTTCCTTTCAGGTCATGAGAG	0.502			NA											3	67					0	0	0.004672	0	0
PCDH15	65217	broad.mit.edu	37	10	55996679	55996679	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:55996679G>T	uc001jju.1	-	9	1284	c.889C>A	c.(889-891)CCC>ACC	p.P297T	PCDH15_uc010qhq.1_Missense_Mutation_p.P302T|PCDH15_uc010qhr.1_Missense_Mutation_p.P297T|PCDH15_uc010qhs.1_Missense_Mutation_p.P302T|PCDH15_uc010qht.1_Missense_Mutation_p.P297T|PCDH15_uc010qhu.1_Missense_Mutation_p.P297T|PCDH15_uc001jjv.1_Missense_Mutation_p.P275T|PCDH15_uc010qhv.1_Missense_Mutation_p.P297T|PCDH15_uc010qhw.1_Missense_Mutation_p.P260T|PCDH15_uc010qhx.1_Missense_Mutation_p.P297T|PCDH15_uc010qhy.1_Missense_Mutation_p.P302T|PCDH15_uc010qhz.1_Missense_Mutation_p.P297T|PCDH15_uc010qia.1_Missense_Mutation_p.P275T|PCDH15_uc010qib.1_Missense_Mutation_p.P275T|PCDH15_uc001jjw.2_Missense_Mutation_p.P297T	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	297	Cadherin 3.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACAATAATGGGGTTCAGTTCT	0.398			NA								HNSCC(58;0.16)			16	200					0.000422831	0.000542757	0.004007	1	0
RHOBTB1	9886	broad.mit.edu	37	10	62632019	62632019	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:62632019C>A	uc001jli.2	-	11	2283	c.1845G>T	c.(1843-1845)TGG>TGT	p.W615C	RHOBTB1_uc001jlh.2_Missense_Mutation_p.W615C|RHOBTB1_uc001jlj.2_Missense_Mutation_p.W615C|RHOBTB1_uc001jlk.2_Missense_Mutation_p.W615C|RHOBTB1_uc009xpe.1_Missense_Mutation_p.W553C|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.W365C	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	615					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					GGTGCAAACACCAGGCGGCCA	0.473			NA											9	104					0.00448238	0.00523342	0.004482	1	0
DNAJC12	56521	broad.mit.edu	37	10	69565369	69565369	+	Silent	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:69565369T>C	uc001jnb.2	-	4	642	c.474A>G	c.(472-474)TCA>TCG	p.S158S		NM_021800	NP_068572	Q9UKB3	DJC12_HUMAN	J domain containing protein 1 isoform a	158					protein folding		heat shock protein binding|unfolded protein binding			breast(1)	1						GCGGGGAGACTGACTTCTCTA	0.393			NA											49	594					0	0	0.00361	0	0
SGPL1	8879	broad.mit.edu	37	10	72614534	72614534	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:72614534G>C	uc001jrm.2	+	5	553	c.331G>C	c.(331-333)GAG>CAG	p.E111Q		NM_003901	NP_003892	O95470	SGPL1_HUMAN	sphingosine-1-phosphate lyase 1	111	Cytoplasmic (Potential).				apoptosis|carboxylic acid metabolic process|ceramide metabolic process|sphingolipid catabolic process	integral to endoplasmic reticulum membrane	carboxy-lyase activity|pyridoxal phosphate binding|sphinganine-1-phosphate aldolase activity				0					Pyridoxal Phosphate(DB00114)	AGTGGACAAAGAGTATGTGAA	0.408	Colon(151;1054 2458 6676 40971)		NA											22	305					0	0	0.00278	0	0
PIPSL	266971	broad.mit.edu	37	10	95720745	95720745	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:95720745C>A	uc009xuj.2	-	1	928	c.409G>T	c.(409-411)GAG>TAG	p.E137*		NR_002319				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						ACAATGAACTCATCGTCGCTG	0.493			NA											8	58					0.000274275	0.000355182	0.004482	1	0
NOC3L	64318	broad.mit.edu	37	10	96099536	96099536	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:96099536G>T	uc001kjq.1	-	17	2010	c.1922C>A	c.(1921-1923)TCA>TAA	p.S641*		NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	nucleolar complex associated 3 homolog	641						nuclear speck|nucleolus	binding			ovary(1)	1		Colorectal(252;0.0897)				GCCAATACTTGAATTTGGAAG	0.368			NA											5	84					1.23904e-05	1.87565e-05	0.000602	1	0
ANKRD2	26287	broad.mit.edu	37	10	99341096	99341096	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:99341096G>T	uc001knw.2	+	6	869	c.660G>T	c.(658-660)TGG>TGT	p.W220C	ANKRD2_uc009xvu.2_Missense_Mutation_p.W220C	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	220	ANK 3.				muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CCATGCATTGGGCCTGCCGCG	0.527			NA											4	65					0.00024832	0.000326385	0.000248	1	0
HPSE2	60495	broad.mit.edu	37	10	100995383	100995383	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:100995383G>A	uc001kpn.1	-	1	237	c.177C>T	c.(175-177)ACC>ACT	p.T59T	HPSE2_uc009xwc.1_Silent_p.T49T|HPSE2_uc001kpo.1_Silent_p.T49T|HPSE2_uc009xwd.1_Silent_p.T49T	NM_021828	NP_068600	Q8WWQ2	HPSE2_HUMAN	heparanase 2	59					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			ovary(1)	1				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GTAGAATCAGGGTCTTTTCCT	0.522			NA											22	274					0	0	0.001882	0	0
SEC31B	25956	broad.mit.edu	37	10	102249904	102249904	+	Silent	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:102249904C>G	uc001krc.1	-	21	2928	c.2826G>C	c.(2824-2826)CTG>CTC	p.L942L	SEC31B_uc010qpo.1_Silent_p.L941L|SEC31B_uc001krd.1_Silent_p.L479L|SEC31B_uc001krf.1_Intron|SEC31B_uc001kre.1_Intron	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	942	Pro-rich.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CTAGTGGTCTCAGAGGAAGCA	0.622			NA											4	87					0	0	0.000248	0	0
ABLIM1	3983	broad.mit.edu	37	10	116203832	116203832	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:116203832C>A	uc010qsg.1	-	17	1988	c.1889G>T	c.(1888-1890)AGG>ATG	p.R630M	ABLIM1_uc010qsh.1_Missense_Mutation_p.R598M|ABLIM1_uc010qsi.1_Missense_Mutation_p.R570M|ABLIM1_uc010qsk.1_Missense_Mutation_p.R507M|ABLIM1_uc009xyp.2_Missense_Mutation_p.R594M|ABLIM1_uc010qsf.1_Missense_Mutation_p.R307M|ABLIM1_uc009xyn.2_Missense_Mutation_p.R246M|ABLIM1_uc010qsj.1_Missense_Mutation_p.R225M|ABLIM1_uc009xyo.2_Missense_Mutation_p.R443M	NM_002313	NP_002304	O14639	ABLM1_HUMAN	actin-binding LIM protein 1 isoform a	630					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(1)	1		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		CAGAGATGACCTTTCCCGGCT	0.438			NA											11	214					1.08611e-07	1.85526e-07	0.000978	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118355742	118355742	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:118355742C>A	uc001lco.1	+	6	500	c.482C>A	c.(481-483)CCC>CAC	p.P161H	PNLIPRP1_uc001lcp.2_Missense_Mutation_p.P161H|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	161					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		TATAGCTACCCCCCTTCCAAA	0.413			NA											15	317					2.31682e-05	3.44775e-05	0.003163	1	0
PDZD8	118987	broad.mit.edu	37	10	119043973	119043973	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:119043973C>A	uc001lde.1	-	5	2470	c.2271G>T	c.(2269-2271)CTG>CTT	p.L757L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	757					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AGGGGGCTTCCAGTCTCAATT	0.423			NA											18	75					3.52763e-06	5.59072e-06	0.00499	1	0
BUB3	9184	broad.mit.edu	37	10	124922239	124922239	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:124922239C>G	uc001lhe.2	+	7	1108	c.866C>G	c.(865-867)ACT>AGT	p.T289S	BUB3_uc001lhf.3_Missense_Mutation_p.T289S|BUB3_uc001lhd.2_Missense_Mutation_p.T289S|BUB3_uc010qud.1_Missense_Mutation_p.T209S	NM_004725	NP_004716	O43684	BUB3_HUMAN	budding uninhibited by benzimidazoles 3 isoform	289					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|attachment of spindle microtubules to kinetochore|cell division|meiosis|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	condensed chromosome kinetochore|cytosol|nucleus	protein binding			ovary(1)	1		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)				AATGATGGGACTACGCTTGCA	0.423	GBM(161;1111 1985 17553 20049 26037)		NA											6	174					0	0	0.001984	0	0
FAM175B	23172	broad.mit.edu	37	10	126523082	126523082	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:126523082G>T	uc001lib.3	+	9	835	c.790G>T	c.(790-792)GCA>TCA	p.A264S		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	264	Potential.					BRISC complex	polyubiquitin binding				0						ATTGCAGCAGGCAGTGTTAAG	0.473			NA											14	49					9.31168e-06	1.44958e-05	0.001855	1	0
MKI67	4288	broad.mit.edu	37	10	129905645	129905645	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:129905645C>A	uc001lke.2	-	13	4654	c.4459G>T	c.(4459-4461)GAG>TAG	p.E1487*	MKI67_uc001lkf.2_Nonsense_Mutation_p.E1127*|MKI67_uc009yav.1_Nonsense_Mutation_p.E1062*|MKI67_uc009yaw.1_Nonsense_Mutation_p.E637*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1487	5.|16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				GTAGTTTTCTCGTGAGTCGTG	0.512			NA											93	377					1.82171e-49	4.03905e-49	0.00361	1	0
STK32C	282974	broad.mit.edu	37	10	134059441	134059441	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:134059441T>A	uc001lle.1	-	2	421	c.281A>T	c.(280-282)CAG>CTG	p.Q94L	STK32C_uc001lld.1_5'UTR|STK32C_uc010quu.1_Missense_Mutation_p.Q107L|STK32C_uc009ybc.1_5'UTR|STK32C_uc009ybd.1_5'UTR|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	94	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCGAAGGATCTGGAAGTGGTC	0.637			NA											14	42					0	0	0.004007	0	0
NAP1L4	4676	broad.mit.edu	37	11	2979700	2979700	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:2979700C>A	uc001lxc.2	-	10	962	c.821G>T	c.(820-822)CGA>CTA	p.R274L	NAP1L4_uc009ydt.2_RNA|NAP1L4_uc010qxm.1_Missense_Mutation_p.R274L|NAP1L4_uc010qxn.1_Missense_Mutation_p.R274L	NM_005969	NP_005960	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	274					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			ovary(1)	1		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		AACAGTGCCTCGACCCTTATG	0.388			NA											6	71					0.00198382	0.00237301	0.001984	1	0
OR51F2	119694	broad.mit.edu	37	11	4842727	4842727	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:4842727C>A	uc010qyn.1	+	1	112	c.112C>A	c.(112-114)CAG>AAG	p.Q38K		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	38	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAAAGCCACCCAGTACTGGAT	0.493			NA											30	428					9.39395e-14	1.93612e-13	0.00632	1	0
OR51L1	119682	broad.mit.edu	37	11	5020793	5020793	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:5020793C>A	uc010qyu.1	+	1	581	c.581C>A	c.(580-582)GCC>GAC	p.A194D		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTACAGATGCCAGGACCAAC	0.428			NA											9	159					4.68919e-08	8.26729e-08	0.008291	1	0
OR51L1	119682	broad.mit.edu	37	11	5020889	5020889	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:5020889C>A	uc010qyu.1	+	1	677	c.677C>A	c.(676-678)ACT>AAT	p.T226N		NM_001004755	NP_001004755	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATTCTTAATACTGTGCTGGAT	0.418			NA											14	113					1.05317e-09	1.97582e-09	0.00245	1	0
CNGA4	1262	broad.mit.edu	37	11	6261622	6261622	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:6261622G>T	uc001mco.2	+	4	705	c.598G>T	c.(598-600)GCA>TCA	p.A200S	CNGA4_uc010raa.1_Intron|CNGA4_uc001mcn.2_Missense_Mutation_p.A160S	NM_001037329	NP_001032406	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	200	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell		cAMP binding			skin(1)	1		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGGGCGTGACGCATGGGTGTA	0.557			NA											12	157					0.00010058	0.000136701	0.001368	1	0
OLFML1	283298	broad.mit.edu	37	11	7530738	7530738	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:7530738C>A	uc001mfi.2	+	3	880	c.528C>A	c.(526-528)TAC>TAA	p.Y176*	OLFML1_uc010raz.1_Nonsense_Mutation_p.Y40*|OLFML1_uc010rba.1_Nonsense_Mutation_p.Y176*	NM_198474	NP_940876	Q6UWY5	OLFL1_HUMAN	olfactomedin-like 1 precursor	176	Olfactomedin-like.					extracellular region				ovary(2)	2				Epithelial(150;6.96e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CAAAGGTGTACTTATTAATTG	0.418			NA											5	179					1.23904e-05	1.87565e-05	0.000602	1	0
LDHA	3939	broad.mit.edu	37	11	18424404	18424404	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:18424404G>T	uc001mok.3	+	5	708	c.436G>T	c.(436-438)GTG>TTG	p.V146L	LDHA_uc010rdc.1_Missense_Mutation_p.V88L|LDHA_uc009yhn.2_Missense_Mutation_p.V146L|LDHA_uc009yho.2_5'UTR|LDHA_uc001mol.3_Missense_Mutation_p.V146L|LDHA_uc010rdd.1_Missense_Mutation_p.V175L	NM_005566	NP_005557	P00338	LDHA_HUMAN	lactate dehydrogenase A isoform 1	146					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)	3					NADH(DB00157)	CTTGACCTACGTGGCTTGGAA	0.413			NA											6	135					0.000157383	0.000210004	0.00308	1	0
NELL1	4745	broad.mit.edu	37	11	20982101	20982101	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:20982101G>T	uc001mqe.2	+	12	1448	c.1295G>T	c.(1294-1296)TGT>TTT	p.C432F	NELL1_uc001mqf.2_Missense_Mutation_p.C432F|NELL1_uc009yid.2_Missense_Mutation_p.C460F|NELL1_uc010rdo.1_Missense_Mutation_p.C375F|NELL1_uc010rdp.1_Missense_Mutation_p.C192F	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	432	EGF-like 1.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TCTGCCTACTGTGAAGGTAAG	0.418			NA											5	162					3.59834e-05	5.19628e-05	0.001168	1	0
NELL1	4745	broad.mit.edu	37	11	21594836	21594836	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:21594836C>A	uc001mqe.2	+	19	2416	c.2263C>A	c.(2263-2265)CTA>ATA	p.L755I	NELL1_uc001mqf.2_Missense_Mutation_p.L708I|NELL1_uc009yid.2_Missense_Mutation_p.L783I|NELL1_uc010rdo.1_Missense_Mutation_p.L698I|NELL1_uc010rdp.1_Missense_Mutation_p.L468I|NELL1_uc001mqh.2_Missense_Mutation_p.L300I	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	755	VWFC 5.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						TGACCCCTGCCTAGCTGATAA	0.512			NA											17	176					2.94398e-08	5.27514e-08	0.007413	1	0
CHST1	8534	broad.mit.edu	37	11	45671882	45671882	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:45671882G>T	uc001mys.1	-	4	1263	c.592C>A	c.(592-594)CGC>AGC	p.R198S		NM_003654	NP_003645	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6)	198	Lumenal (Potential).				galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			skin(4)|pancreas(1)	5				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		CTGCGCTCGCGGCACGCCTCG	0.682			NA											4	18					1.024e-07	1.78387e-07	0.000602	1	0
LOC440040	440040	broad.mit.edu	37	11	49805625	49805625	+	Splice_Site	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:49805625G>T	uc010rhy.1	+	3	1299	c.821_splice	c.e3+1	p.R274_splice	LOC440040_uc009ymb.2_Splice_Site_p.R274_splice	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						TTCTGGGCAGGTGAGTGATGA	0.478			NA											12	105					9.31168e-06	1.44958e-05	0.001855	1	0
OR5L1	219437	broad.mit.edu	37	11	55579402	55579402	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:55579402G>T	uc001nhw.1	+	1	460	c.460G>T	c.(460-462)GTG>TTG	p.V154L		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				CTGTGGGACGGTGTGTTCTCT	0.458			NA											26	205					7.38237e-10	1.40297e-09	0.00632	1	0
OR5L1	219437	broad.mit.edu	37	11	55579854	55579854	+	Silent	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:55579854G>C	uc001nhw.1	+	1	912	c.912G>C	c.(910-912)GTG>GTC	p.V304V		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TCAGAAAAGTGATGGGCTCCA	0.468			NA											3	54					0	0	0.000248	0	0
OR5D18	219438	broad.mit.edu	37	11	55587432	55587432	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:55587432G>A	uc010rin.1	+	1	327	c.327G>A	c.(325-327)GTG>GTA	p.V109V		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				GTACCTTTGTGGTCACTGAAT	0.433			NA											13	344					0	0	0.001855	0	0
SPRYD5	84767	broad.mit.edu	37	11	55659052	55659052	+	Missense_Mutation	SNP	C	C	A	rs148245438	byFrequency	TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:55659052C>A	uc010rip.1	+	7	1395	c.1303C>A	c.(1303-1305)CCC>ACC	p.P435T	SPRYD5_uc010riq.1_Missense_Mutation_p.P292T	NM_032681	NP_116070	Q9BSJ1	SPRY5_HUMAN	SPRY domain containing 5	435	B30.2/SPRY.					intracellular	zinc ion binding				0		all_epithelial(135;0.226)				ATACACCATCCCCAATTGCTC	0.458			NA											15	230					0.000422831	0.000542757	0.004007	1	0
OR8H3	390152	broad.mit.edu	37	11	55890175	55890175	+	Silent	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:55890175T>C	uc001nii.1	+	1	327	c.327T>C	c.(325-327)ACT>ACC	p.T109T		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					TCTTGGGTACTGCTGAATGTT	0.463			NA											23	566					0	0	0.00278	0	0
DLG2	1740	broad.mit.edu	37	11	84245668	84245668	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:84245668G>A	uc001paj.2	-	2	452	c.149C>T	c.(148-150)TCT>TTT	p.S50F	DLG2_uc010rsz.1_Missense_Mutation_p.S50F|DLG2_uc010rta.1_Missense_Mutation_p.S50F|DLG2_uc001pak.2_Missense_Mutation_p.S155F|DLG2_uc001pal.1_Missense_Mutation_p.S50F	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	50						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTCTATTTGAGAGAGGTTCTT	0.423			NA											21	202					0	0	0.002299	0	0
PPP2R1B	5519	broad.mit.edu	37	11	111636081	111636081	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:111636081A>G	uc001plx.1	-	2	226	c.142T>C	c.(142-144)TCA>CCA	p.S48P	PPP2R1B_uc001plw.1_Missense_Mutation_p.S48P|PPP2R1B_uc010rwi.1_Intron|PPP2R1B_uc010rwj.1_5'UTR|PPP2R1B_uc010rwk.1_Missense_Mutation_p.S48P|PPP2R1B_uc010rwl.1_Missense_Mutation_p.S48P	NM_002716	NP_002707	P30154	2AAB_HUMAN	beta isoform of regulatory subunit A, protein	48	HEAT 1.						protein binding				0		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|Epithelial(105;2.36e-06)|all cancers(92;3.78e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0761)		GCAATTGTTGATAACTTCTTA	0.368			NA											12	142					0	0	0.000978	0	0
DSCAML1	57453	broad.mit.edu	37	11	117302317	117302317	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:117302317C>A	uc001prh.1	-	31	5489	c.5487G>T	c.(5485-5487)GTG>GTT	p.V1829V		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1769	Cytoplasmic (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GCTGGGAGCCCACGGTGCGCC	0.647			NA											9	90					0.00136819	0.00167308	0.001368	1	0
ABCG4	64137	broad.mit.edu	37	11	119027327	119027327	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:119027327G>T	uc001pvs.2	+	8	1200	c.864G>T	c.(862-864)CTG>CTT	p.L288L	ABCG4_uc009zar.2_Silent_p.L288L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	288	Cytoplasmic (Potential).|ABC transporter.				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		TCACCAACCTGATCCCCTATC	0.577			NA											19	123					1.50039e-11	2.9405e-11	0.001882	1	0
FAM118B	79607	broad.mit.edu	37	11	126110730	126110730	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:126110730G>T	uc001qdf.2	+	4	313	c.130G>T	c.(130-132)GTG>TTG	p.V44L	FAM118B_uc009zca.2_Missense_Mutation_p.V48L|FAM118B_uc001qdg.2_Missense_Mutation_p.V44L	NM_024556	NP_078832	Q9BPY3	F118B_HUMAN	hypothetical protein LOC79607	44											0	all_hematologic(175;0.145)	Breast(109;0.00156)|Lung NSC(97;0.00948)|all_lung(97;0.0101)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0784)		TCGAGAACTTGTGCTAGTGAT	0.453			NA											38	355					1.47244e-24	3.23202e-24	0.00623	1	0
OPCML	4978	broad.mit.edu	37	11	132306643	132306643	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr11:132306643G>A	uc001qgs.2	-	5	745	c.695C>T	c.(694-696)ACT>ATT	p.T232I	OPCML_uc001qgu.2_Missense_Mutation_p.T225I|OPCML_uc010sck.1_Missense_Mutation_p.T232I|OPCML_uc001qgt.2_Missense_Mutation_p.T231I|OPCML_uc010scl.1_Missense_Mutation_p.T191I	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	232	Ig-like C2-type 3.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TGAAACACCAGTGTTCTTGGC	0.378			NA											4	64					0	0	0.000602	0	0
CLEC6A	93978	broad.mit.edu	37	12	8610547	8610547	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:8610547G>C	uc001qum.1	+	2	202	c.85G>C	c.(85-87)GCA>CCA	p.A29P		NM_001007033	NP_001007034	Q6EIG7	CLC6A_HUMAN	dectin-2	29	Helical; Signal-anchor for type II membrane protein; (Potential).				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)	1	Lung SC(5;0.184)					GATTTCCATTGCACTCCTCAG	0.483			NA											9	64					0	0	0.004482	0	0
CLEC1B	51266	broad.mit.edu	37	12	10149523	10149523	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:10149523G>T	uc001qwu.2	-	4	560	c.360C>A	c.(358-360)AAC>AAA	p.N120K	CLEC1B_uc009zhd.2_Missense_Mutation_p.N87K	NM_016509	NP_057593	Q9P126	CLC1B_HUMAN	C-type lectin domain family 1, member B isoform	120	C-type lectin.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	protein binding|sugar binding|transmembrane receptor activity				0						CCCATGTTAAGTTGTGCCTGA	0.433			NA											29	214					9.39395e-14	1.93612e-13	0.00632	1	0
RERGL	79785	broad.mit.edu	37	12	18237551	18237551	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:18237551C>A	uc001rdq.2	-	5	429	c.235G>T	c.(235-237)GGG>TGG	p.G79W	RERGL_uc001rdr.2_Missense_Mutation_p.G78W	NM_024730	NP_079006	Q9H628	RERGL_HUMAN	RERG/RAS-like	79	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity				0						ATAACAAACCCATCTGCCCAG	0.403			NA											16	155					0.00074312	0.000918957	0.006122	1	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:25398284C>A	uc001rgp.1	-	2	216	c.35G>T	c.(34-36)GGT>GTT	p.G12V	KRAS_uc001rgq.1_Missense_Mutation_p.G12V|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	26					1.23904e-05	1.87565e-05	0.000602	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30879010	30879010	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:30879010C>A	uc001rji.1	-	9	2546	c.1795G>T	c.(1795-1797)GTG>TTG	p.V599L	CAPRIN2_uc001rjf.1_Missense_Mutation_p.V396L|CAPRIN2_uc001rjg.1_Missense_Mutation_p.V266L|CAPRIN2_uc001rjh.1_Missense_Mutation_p.V599L|CAPRIN2_uc001rjj.1_Missense_Mutation_p.V266L|CAPRIN2_uc001rjk.3_Missense_Mutation_p.V599L|CAPRIN2_uc001rjl.3_Missense_Mutation_p.V599L|CAPRIN2_uc001rjm.1_Missense_Mutation_p.V266L	NM_001002259	NP_001002259	Q6IMN6	CAPR2_HUMAN	C1q domain containing 1 isoform 1	599					negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			ovary(1)|central_nervous_system(1)	2	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GGCTGATGCACAGGCTTAGGC	0.403			NA											9	81					0.000274275	0.000355182	0.004482	1	0
BICD1	636	broad.mit.edu	37	12	32447000	32447000	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:32447000C>A	uc001rku.2	+	3	580	c.499C>A	c.(499-501)CGG>AGG	p.R167R	BICD1_uc001rkv.2_Silent_p.R167R|BICD1_uc010skd.1_RNA	NM_001714	NP_001705	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 isoform 1	167	Potential.				anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			large_intestine(1)|central_nervous_system(1)	2	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			CCGGGAGGCACGGCTCCTTCA	0.398			NA											7	58					0.000157383	0.000210004	0.00308	1	0
OR6C4	341418	broad.mit.edu	37	12	55945335	55945335	+	Nonsense_Mutation	SNP	G	G	T	rs78982301	byFrequency	TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:55945335G>T	uc010spp.1	+	1	325	c.325G>T	c.(325-327)GAG>TAG	p.E109*		NM_001005494	NP_001005494	Q8NGE1	OR6C4_HUMAN	olfactory receptor, family 6, subfamily C,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TGGAGCTACCGAGTTTTACCT	0.423			NA											10	147					0.00621372	0.0072356	0.006214	1	0
E2F7	144455	broad.mit.edu	37	12	77449706	77449706	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:77449706C>A	uc001sym.3	-	3	534	c.298G>T	c.(298-300)GAC>TAC	p.D100Y	E2F7_uc001syn.2_Missense_Mutation_p.D100Y	NM_203394	NP_976328	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	100					cell cycle	transcription factor complex	DNA binding|identical protein binding			upper_aerodigestive_tract(1)|ovary(1)|kidney(1)	3						TTCTCCCGGTCCCTTATATCT	0.463			NA											14	204					3.27435e-08	5.84326e-08	0.00245	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85450741	85450741	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:85450741A>T	uc001tac.2	+	8	2281	c.2170A>T	c.(2170-2172)AGC>TGC	p.S724C	LRRIQ1_uc001tab.1_Missense_Mutation_p.S724C|LRRIQ1_uc001taa.1_Missense_Mutation_p.S699C	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	724										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TGAACCTGATAGCATGACCTG	0.353			NA											23	579					0	0	0.00333	0	0
PLXNC1	10154	broad.mit.edu	37	12	94641809	94641809	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:94641809A>T	uc001tdc.2	+	13	2768	c.2519A>T	c.(2518-2520)TAT>TTT	p.Y840F		NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	840	Extracellular (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						ACCCTGCAGTATCGGGAGGAC	0.483			NA											5	110					0	0	0.000602	0	0
C12orf63	374467	broad.mit.edu	37	12	97114182	97114182	+	Splice_Site	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:97114182G>T	uc001tet.1	+	17	2158	c.2080_splice	c.e17-1	p.S694_splice		NM_198520	NP_940922	Q6ZTY8	CL063_HUMAN	hypothetical protein LOC374467											skin(6)|ovary(1)	7						CCTTTCCTTAGTCGATGTTAC	0.423			NA											6	70					4.68919e-08	8.26729e-08	0.008291	1	0
ANKS1B	56899	broad.mit.edu	37	12	99223026	99223026	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:99223026C>G	uc001tge.1	-	19	3409	c.2992G>C	c.(2992-2994)GAT>CAT	p.D998H	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc001tgk.2_Missense_Mutation_p.D295H|ANKS1B_uc010svd.1_Missense_Mutation_p.D4H|ANKS1B_uc001tgd.1_Intron|ANKS1B_uc009ztq.2_5'UTR|ANKS1B_uc010sve.1_Missense_Mutation_p.D4H|ANKS1B_uc001tgh.3_Missense_Mutation_p.D4H|ANKS1B_uc001tgi.2_Missense_Mutation_p.D224H|ANKS1B_uc009ztr.2_Intron|ANKS1B_uc001tgj.2_Intron|ANKS1B_uc009ztp.2_Missense_Mutation_p.D4H|ANKS1B_uc010svf.1_Missense_Mutation_p.D4H|ANKS1B_uc001tgg.3_Intron|ANKS1B_uc010svg.1_Intron|ANKS1B_uc009zts.1_Missense_Mutation_p.D224H	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	998						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		CTCCTTGCATCGCCCTGCATG	0.463			NA											15	249					0	0	0.00245	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705565	41705565	+	Silent	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr13:41705565T>A	uc001uxu.1	-	1	1372	c.1083A>T	c.(1081-1083)CCA>CCT	p.P361P	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Silent_p.P295P|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	361							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CCCCCGAGTATGGATCACAGC	0.507			NA											9	143					0	0	0.008291	0	0
TBC1D4	9882	broad.mit.edu	37	13	75936627	75936627	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr13:75936627C>A	uc001vjl.1	-	2	962	c.615G>T	c.(613-615)CTG>CTT	p.L205L	TBC1D4_uc010aer.2_Silent_p.L205L|TBC1D4_uc010aes.2_Silent_p.L205L	NM_014832	NP_055647	O60343	TBCD4_HUMAN	TBC1 domain family, member 4	205	PID 1.					cytoplasm	Rab GTPase activator activity			ovary(4)|central_nervous_system(1)|skin(1)	6		Prostate(6;0.014)|Breast(118;0.0982)		GBM - Glioblastoma multiforme(99;0.0116)		TTCCACAGTACAGGACTTCGA	0.507			NA											35	294					9.04072e-19	1.92664e-18	0.003271	1	0
RNF219	79596	broad.mit.edu	37	13	79190730	79190730	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr13:79190730G>C	uc001vkw.1	-	6	1225	c.1166C>G	c.(1165-1167)CCT>CGT	p.P389R	uc001vku.1_RNA|RNF219_uc010afb.1_Missense_Mutation_p.P199R|RNF219_uc010afc.2_Intron	NM_024546	NP_078822	Q5W0B1	RN219_HUMAN	ring finger protein 219	389							zinc ion binding			large_intestine(2)	2		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		AGGAGTACAAGGAGCTGGAAG	0.423			NA											17	166					0	0	0.004007	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215964	20215964	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr14:20215964C>A	uc010tkt.1	+	1	378	c.378C>A	c.(376-378)GCC>GCA	p.A126A		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGTATGTTGCCATCTGTAACC	0.493			NA											6	122					3.59834e-05	5.19628e-05	0.001168	1	0
OR4N5	390437	broad.mit.edu	37	14	20612538	20612538	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr14:20612538T>A	uc010tla.1	+	1	644	c.644T>A	c.(643-645)CTG>CAG	p.L215Q		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	215	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CTGGGCCTTCTGGCCTCCTAT	0.512			NA											25	137					0	0	0.00333	0	0
Unknown	0	broad.mit.edu	37	14	28734072	28734072	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr14:28734072G>T	uc001wqd.2	+	1	453	c.313G>T	c.(313-315)GAA>TAA	p.E105*						SubName: Full=cDNA FLJ60537, highly similar to BCL2/adenovirus E1B 19 kDa protein-interacting protein 3;												NA						GAGAAGGAAGGAAGTTGAAAG	0.438			NA											10	106					9.70103e-10	1.83567e-09	0.008291	1	0
NID2	22795	broad.mit.edu	37	14	52508829	52508829	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr14:52508829G>A	uc001wzo.2	-	7	2053	c.1819C>T	c.(1819-1821)CTC>TTC	p.L607F	NID2_uc010tqs.1_Missense_Mutation_p.L607F|NID2_uc010tqt.1_Missense_Mutation_p.L607F|NID2_uc001wzp.2_Missense_Mutation_p.L607F	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	607	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					TCACCTGCGAGGCTGAAGCCG	0.577			NA											4	120					0	0	0.000602	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412404	105412404	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr14:105412404G>T	uc010axc.1	-	7	9504	c.9384C>A	c.(9382-9384)GAC>GAA	p.D3128E	AHNAK2_uc001ypx.2_Missense_Mutation_p.D3028E	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3128						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCAGGGACAGGTCCCCCTCCA	0.627			NA											17	224					2.21704e-12	4.44419e-12	0.00278	1	0
AHNAK2	113146	broad.mit.edu	37	14	105420209	105420209	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr14:105420209G>T	uc010axc.1	-	7	1699	c.1579C>A	c.(1579-1581)CTG>ATG	p.L527M	AHNAK2_uc001ypx.2_Missense_Mutation_p.L427M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	527						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCACCCTTCAGGCCAGTACCC	0.557			NA											6	127					0.00198382	0.00237301	0.001984	1	0
MKRN3	7681	broad.mit.edu	37	15	23811793	23811793	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:23811793C>T	uc001ywh.3	+	1	1340	c.864C>T	c.(862-864)GCC>GCT	p.A288A	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Silent_p.A288A	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	288	Makorin-type Cys-His.					ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		ATATGAGGGCCTGCATTGAAG	0.527			NA											7	58					0	0	0.001984	0	0
TJP1	7082	broad.mit.edu	37	15	30024963	30024963	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:30024963C>A	uc001zcr.2	-	14	2268	c.1793G>T	c.(1792-1794)CGT>CTT	p.R598L	TJP1_uc010azl.2_Missense_Mutation_p.R586L|TJP1_uc001zcq.2_Missense_Mutation_p.R602L|TJP1_uc001zcs.2_Missense_Mutation_p.R598L	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	598	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		GAAGTCAGCACGGTCTCCGCC	0.443	Melanoma(77;681 1843 6309 6570)		NA											5	56					0.000602214	0.000753197	0.000602	1	0
TRPM1	4308	broad.mit.edu	37	15	31294304	31294304	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:31294304G>T	uc001zfm.2	-	27	4661	c.4533C>A	c.(4531-4533)GTC>GTA	p.V1511V	TRPM1_uc010azy.2_Silent_p.V1418V|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1511	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TTGCTTCAGCGACATGGTGTT	0.458			NA											29	412					1.74807e-11	3.41068e-11	0.002096	1	0
RYR3	6263	broad.mit.edu	37	15	33926871	33926871	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:33926871C>A	uc001zhi.2	+	25	3182	c.3112C>A	c.(3112-3114)CGG>AGG	p.R1038R	RYR3_uc010bar.2_Silent_p.R1038R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1038	2.|B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGACAGCCTGCGGGAAGCTGT	0.468			NA											7	106					0.00198382	0.00237301	0.001984	1	0
AQR	9716	broad.mit.edu	37	15	35198869	35198869	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:35198869T>C	uc001ziv.2	-	18	1889	c.1708A>G	c.(1708-1710)ACA>GCA	p.T570A		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	570						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		TAAGGTTTTGTGGGACGTACG	0.388			NA											4	116					0	0	0.000248	0	0
CHD2	1106	broad.mit.edu	37	15	93496623	93496623	+	Silent	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:93496623A>T	uc002bsp.2	+	14	2114	c.1539A>T	c.(1537-1539)CTA>CTT	p.L513L	CHD2_uc002bso.1_Silent_p.L513L	NM_001271	NP_001262	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	513	ATP (Potential).|Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|skin(1)	2	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			AAATGGGCCTAGGAAAGACCA	0.398			NA											7	121					0	0	0.00308	0	0
CHSY1	22856	broad.mit.edu	37	15	101717776	101717776	+	Silent	SNP	T	T	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr15:101717776T>G	uc002bwt.1	-	4	2709	c.2226A>C	c.(2224-2226)GTA>GTC	p.V742V	CHSY1_uc010usd.1_Silent_p.V470V	NM_014918	NP_055733	Q86X52	CHSS1_HUMAN	chondroitin sulfate synthase 1	742	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity				0	Lung NSC(78;0.00217)|all_lung(78;0.00271)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GGACGTGGACTACTCCTACTT	0.512			NA											5	97					0	0	0.001168	0	0
TSC2	7249	broad.mit.edu	37	16	2122317	2122317	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:2122317A>T	uc002con.2	+	20	2279	c.2173A>T	c.(2173-2175)ACT>TCT	p.T725S	TSC2_uc010bsd.2_Missense_Mutation_p.T725S|TSC2_uc002coo.2_Missense_Mutation_p.T725S|TSC2_uc010uvv.1_Missense_Mutation_p.T688S|TSC2_uc010uvw.1_Missense_Mutation_p.T676S|TSC2_uc002cop.2_Missense_Mutation_p.T525S	NM_000548	NP_000539	P49815	TSC2_HUMAN	tuberous sclerosis 2 isoform 1	725					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			central_nervous_system(4)|lung(3)|ovary(2)|pancreas(1)	10		Hepatocellular(780;0.0202)				GCTCATCTTTACTTCCCCTTG	0.602			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				5	144					0	0	0.000602	0	0
GRIN2A	2903	broad.mit.edu	37	16	9943738	9943738	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:9943738C>A	uc002czo.3	-	5	1751	c.1203G>T	c.(1201-1203)CCG>CCT	p.P401P	GRIN2A_uc010uym.1_Silent_p.P401P|GRIN2A_uc010uyn.1_Silent_p.P244P|GRIN2A_uc002czr.3_Silent_p.P401P	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	401	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGTTGTCATCCGGCTCACAGT	0.587			NA											6	123					3.59834e-05	5.19628e-05	0.001168	1	0
ACSM5	54988	broad.mit.edu	37	16	20439113	20439113	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:20439113C>T	uc002dhe.2	+	7	1072	c.925C>T	c.(925-927)CTC>TTC	p.L309F		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	309					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TGTTTAGACTCTCTCCAAATT	0.473			NA											22	310					0	0	0.00333	0	0
GTF3C1	2975	broad.mit.edu	37	16	27492447	27492447	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:27492447C>T	uc002dov.1	-	27	4189	c.4149G>A	c.(4147-4149)AGG>AGA	p.R1383R	GTF3C1_uc002dou.2_Silent_p.R1383R	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1383						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						GGTTAGAATTCCTTAGGGCTG	0.463			NA											7	124					0	0	0.00308	0	0
CDH11	1009	broad.mit.edu	37	16	65005896	65005896	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:65005896A>C	uc002eoi.2	-	10	1896	c.1462T>G	c.(1462-1464)TTT>GTT	p.F488V	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Missense_Mutation_p.F488V|CDH11_uc010vin.1_Missense_Mutation_p.F362V	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	488	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GGGGCAGCAAACTTGGGAGCA	0.483			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			3	53					0	0	0.004672	0	0
ZNF23	7571	broad.mit.edu	37	16	71482488	71482488	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:71482488C>A	uc002faf.2	-	6	2254	c.1440G>T	c.(1438-1440)GAG>GAT	p.E480D	ZNF23_uc002fad.2_Missense_Mutation_p.E422D|ZNF23_uc002fae.2_Missense_Mutation_p.E422D|ZNF23_uc010vmf.1_Missense_Mutation_p.E422D|ZNF23_uc002fag.2_Missense_Mutation_p.E422D|ZNF23_uc002fah.2_Missense_Mutation_p.E480D|ZNF23_uc002fai.2_Missense_Mutation_p.E519D	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	480	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		ATCTCCCACACTCATTACATT	0.423			NA											8	108					0.00307968	0.00362461	0.00308	1	0
TCF25	22980	broad.mit.edu	37	16	89967042	89967042	+	Splice_Site	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr16:89967042G>T	uc002fpb.2	+	12	1304	c.1222_splice	c.e12-1	p.A408_splice	TCF25_uc002fpc.2_Splice_Site_p.A173_splice	NM_014972	NP_055787	Q9BQ70	TCF25_HUMAN	NULP1						heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		GTCCCTCGTAGGCTCATCGGA	0.527			NA											7	100					0.00198382	0.00237301	0.001984	1	0
PRPF8	10594	broad.mit.edu	37	17	1579293	1579293	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:1579293C>A	uc002fte.2	-	18	2722	c.2608G>T	c.(2608-2610)GCC>TCC	p.A870S		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	870						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		TTATCGTAGGCCTGCTCGATC	0.532			NA											7	58					8.12818e-05	0.000111161	0.001984	1	0
TRPV2	51393	broad.mit.edu	37	17	16326965	16326965	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:16326965T>C	uc002gpy.2	+	5	1175	c.808T>C	c.(808-810)TAT>CAT	p.Y270H	TRPV2_uc002gpz.2_Intron	NM_016113	NP_057197	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel,	270	Cytoplasmic (Potential).|Required for interaction with SLC50A1 (By similarity).|ANK 5.				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			ovary(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GACCAGCATGTATGATGGGCT	0.602			NA											7	67					0	0	0.001984	0	0
CCT6B	10693	broad.mit.edu	37	17	33288403	33288403	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:33288403T>C	uc002hig.2	-	1	104	c.10A>G	c.(10-12)ATA>GTA	p.I4V	CCT6B_uc010ctg.2_Missense_Mutation_p.I4V|CCT6B_uc010wcc.1_Missense_Mutation_p.I4V|ZNF830_uc002hih.3_5'Flank	NM_006584	NP_006575	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B	4					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			pancreas(1)	1		Ovarian(249;0.17)				ACGGCCTTTATCGCAGCCATA	0.577			NA											10	47					0	0	0.001368	0	0
WIPF2	147179	broad.mit.edu	37	17	38416822	38416822	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:38416822G>T	uc002hug.1	+	3	339	c.99G>T	c.(97-99)GAG>GAT	p.E33D	WIPF2_uc010cwv.1_Missense_Mutation_p.E33D|WIPF2_uc002huh.1_5'UTR|WIPF2_uc010cww.1_5'UTR|WIPF2_uc002hui.1_Missense_Mutation_p.E33D|WIPF2_uc010cwx.1_Missense_Mutation_p.E33D|WIPF2_uc010cwy.1_Missense_Mutation_p.E33D	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	33						cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GTAGAGATGAGCAGCGGGGTC	0.458			NA								HNSCC(43;0.11)			6	105					1.12685e-05	1.74186e-05	0.004482	1	0
CRHR1	1394	broad.mit.edu	37	17	43906655	43906655	+	Silent	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:43906655C>G	uc010dap.2	+	5	667	c.402C>G	c.(400-402)CTC>CTG	p.L134L	CRHR1_uc010wjx.1_5'UTR|CRHR1_uc002ijp.2_Silent_p.L33L|CRHR1_uc002ijm.2_Silent_p.L134L|CRHR1_uc002ijn.2_Silent_p.L94L|CRHR1_uc010dar.2_Silent_p.L134L|CRHR1_uc010dao.2_Silent_p.L33L|CRHR1_uc010daq.2_5'UTR|CRHR1_uc010das.1_RNA|CRHR1_uc002ijo.1_RNA	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	134	Helical; Name=1; (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		TGGTGGCCCTCCTGGTGGCCT	0.577	Ovarian(110;57 1568 10207 38216 49865)		NA											3	60					0	0	0.004672	0	0
KIAA1267	284058	broad.mit.edu	37	17	44249162	44249162	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:44249162C>A	uc002ikb.2	-	1	433	c.348G>T	c.(346-348)CAG>CAT	p.Q116H	KIAA1267_uc002ikc.2_Missense_Mutation_p.Q116H|KIAA1267_uc002ikd.2_Missense_Mutation_p.Q116H|KIAA1267_uc010dav.2_Missense_Mutation_p.Q116H	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	116						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				GTTCATAGGACTGAGATAAGA	0.458			NA											17	410					0.000566183	0.000720448	0.00499	1	0
KPNB1	3837	broad.mit.edu	37	17	45752095	45752095	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:45752095G>C	uc002ilt.1	+	15	2195	c.1859G>C	c.(1858-1860)GGG>GCG	p.G620A	KPNB1_uc010wkw.1_Missense_Mutation_p.G475A|KPNB1_uc010wkx.1_Missense_Mutation_p.G404A	NM_002265	NP_002256	Q14974	IMB1_HUMAN	karyopherin beta 1	620	HEAT 7.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AGCACAGCTGGGTCTGGGGGA	0.483			NA											12	180					0	0	0.000978	0	0
COIL	8161	broad.mit.edu	37	17	55038337	55038337	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:55038337T>G	uc002iuu.2	-	1	75	c.44A>C	c.(43-45)TAC>TCC	p.Y15S		NM_004645	NP_004636	P38432	COIL_HUMAN	coilin	15						Cajal body|nucleolus	protein C-terminus binding			ovary(1)	1	Breast(9;6.15e-08)					TGGCGGCGGGTAATCAAATTG	0.587			NA									OREG0024594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	9					0	0	0.00499	0	0
KCNJ16	3773	broad.mit.edu	37	17	68128403	68128403	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:68128403G>T	uc002jin.2	+	5	661	c.175G>T	c.(175-177)GTT>TTT	p.V59F	KCNJ16_uc002jio.2_Missense_Mutation_p.V59F|KCNJ16_uc002jip.2_Missense_Mutation_p.V59F|KCNJ16_uc002jiq.2_Missense_Mutation_p.V91F	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	59	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					AAGCTATGTGGTTGACATCTT	0.403			NA											11	209					0.000673444	0.000835147	0.008291	1	0
TYMS	7298	broad.mit.edu	37	18	662311	662311	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:662311A>G	uc010dka.1	+	3	584	c.445A>G	c.(445-447)ATG>GTG	p.M149V	TYMS_uc010dkb.1_Missense_Mutation_p.M149V|TYMS_uc010dkc.1_Intron	NM_001071	NP_001062	P04818	TYSY_HUMAN	thymidylate synthase	149					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity				0					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	ATACAGAGATATGGAATCAGG	0.498			NA											20	376					0	0	0.007413	0	0
EPB41L3	23136	broad.mit.edu	37	18	5428374	5428374	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:5428374G>T	uc002kmt.1	-	9	1089	c.1003C>A	c.(1003-1005)CCC>ACC	p.P335T	EPB41L3_uc010wzh.1_Missense_Mutation_p.P335T|EPB41L3_uc002kmu.1_Missense_Mutation_p.P335T|EPB41L3_uc010dkq.1_Missense_Mutation_p.P226T|EPB41L3_uc010dks.1_Missense_Mutation_p.P357T	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	335	FERM.				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						AGAACCTTGGGCCAGGCAAAT	0.443			NA											11	208					3.07112e-06	4.88486e-06	0.000978	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14851650	14851650	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:14851650A>T	uc010dlo.2	+	36	3530	c.3350A>T	c.(3349-3351)AAG>ATG	p.K1117M	ANKRD30B_uc010xal.1_Missense_Mutation_p.K259M	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1202	Potential.									ovary(1)|skin(1)	2						GAGGACATTAAGATTTTACAA	0.348			NA											4	50					0	0	0.000602	0	0
DSC1	1823	broad.mit.edu	37	18	28737519	28737519	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:28737519G>T	uc002kwn.2	-	3	428	c.166C>A	c.(166-168)CTC>ATC	p.L56I	DSC1_uc002kwm.2_Missense_Mutation_p.L56I	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	56					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GCCGACTTGAGACACTCCTCC	0.448			NA											9	88					2.17888e-05	3.2646e-05	0.006214	1	0
PIGN	23556	broad.mit.edu	37	18	59777144	59777144	+	Silent	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:59777144C>G	uc002lii.3	-	18	1945	c.1497G>C	c.(1495-1497)CTG>CTC	p.L499L	PIGN_uc002lij.3_Silent_p.L499L	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	499	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				CTTGAATCAGCAGAAAAAATG	0.393			NA											9	126					0	0	0.004482	0	0
SERPINB13	5275	broad.mit.edu	37	18	61264592	61264592	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:61264592C>A	uc002ljc.2	+	8	1339	c.1171C>A	c.(1171-1173)CCT>ACT	p.P391T	SERPINB13_uc002ljd.2_Missense_Mutation_p.P255T|SERPINB13_uc010xep.1_Missense_Mutation_p.P400T|SERPINB13_uc010xeq.1_Missense_Mutation_p.P212T|SERPINB13_uc010xer.1_Missense_Mutation_p.P212T	NM_012397	NP_036529	Q9UIV8	SPB13_HUMAN	serine (or cysteine) proteinase inhibitor, clade	391					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)	1						ATTTTCTTCTCCTTAAGATGA	0.403			NA											7	134					1.76689e-08	3.19204e-08	0.006214	1	0
SERPINB4	6318	broad.mit.edu	37	18	61306540	61306540	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr18:61306540T>A	uc002ljf.2	-	7	733	c.647A>T	c.(646-648)TAC>TTC	p.Y216F	SERPINB4_uc002lje.2_Intron|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	216					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						AAAGGAATTGTATTGCCTCAT	0.363			NA											4	82					0	0	0.000248	0	0
POLRMT	5442	broad.mit.edu	37	19	625204	625204	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:625204G>A	uc002lpf.1	-	4	929	c.873C>T	c.(871-873)GGC>GGT	p.G291G		NM_005035	NP_005026	O00411	RPOM_HUMAN	mitochondrial DNA-directed RNA polymerase	291					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			ovary(1)|pancreas(1)	2		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGAGTCAAGCCGGCATCCT	0.627			NA											4	92					0	0	0.000248	0	0
MUC16	94025	broad.mit.edu	37	19	9058299	9058299	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:9058299G>A	uc002mkp.2	-	3	29351	c.29147C>T	c.(29146-29148)ACG>ATG	p.T9716M		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9718	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCGAGGGCTCGTCCATGACAG	0.468			NA											6	47					0	0	0.001168	0	0
MUC16	94025	broad.mit.edu	37	19	9073838	9073838	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:9073838G>C	uc002mkp.2	-	3	13812	c.13608C>G	c.(13606-13608)AAC>AAG	p.N4536K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	4538	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCACTGCTTTGTTTATGGAAG	0.453			NA											5	72					0	0	0.000602	0	0
OR7G2	390882	broad.mit.edu	37	19	9213200	9213200	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:9213200G>T	uc010xkk.1	-	1	783	c.783C>A	c.(781-783)ACC>ACA	p.T261T		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	240	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GAGACCCACAGGTGGAAACTG	0.478	Esophageal Squamous(67;143 1448 28637 40648)		NA											6	109					0.00116845	0.00143281	0.001168	1	0
CD97	976	broad.mit.edu	37	19	14512216	14512216	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:14512216G>A	uc002myl.2	+	10	1039	c.916G>A	c.(916-918)GAT>AAT	p.D306N	CD97_uc002mym.2_Missense_Mutation_p.D257N|CD97_uc002myn.2_Missense_Mutation_p.D213N	NM_078481	NP_510966	P48960	CD97_HUMAN	CD97 antigen isoform 1 precursor	306	Extracellular (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(3)|breast(1)	4						CAAATTGGTGGATGAACTGAT	0.567			NA											4	31					0	0	0.000248	0	0
ZNF99	7652	broad.mit.edu	37	19	22940448	22940448	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:22940448G>C	uc010xrh.1	-	5	1990	c.1990C>G	c.(1990-1992)CAT>GAT	p.H664D		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTGCAGTATGAATTACCTTA	0.353			NA											10	108					0	0	0.000978	0	0
ATP1A3	478	broad.mit.edu	37	19	42490070	42490070	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:42490070C>T	uc002osg.2	-	6	706	c.552G>A	c.(550-552)AAG>AAA	p.K184K	ATP1A3_uc010xwf.1_Silent_p.K195K|ATP1A3_uc010xwg.1_Silent_p.K154K|ATP1A3_uc010xwh.1_Silent_p.K197K|ATP1A3_uc002osh.2_Silent_p.K184K	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	184	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						GGTCTCCACCCTTGATCTCCA	0.572			NA											8	115					0	0	0.00308	0	0
PSG6	5675	broad.mit.edu	37	19	43414968	43414968	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:43414968G>T	uc002ovj.1	-	3	522	c.470C>A	c.(469-471)CCC>CAC	p.P157H	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.P164H|PSG6_uc002ovi.2_Missense_Mutation_p.P158H|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_5'UTR|PSG6_uc002ovf.1_Missense_Mutation_p.P157H|PSG6_uc002ovg.1_Missense_Mutation_p.P157H	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	157	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				GACCTCCCTGGGGTTTAAGTT	0.537			NA											15	220					4.7546e-09	8.69696e-09	0.004007	1	0
PSG7	5676	broad.mit.edu	37	19	43430641	43430641	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:43430641G>T	uc002ovl.3	-	5	1039	c.937C>A	c.(937-939)CGG>AGG	p.R313R	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Silent_p.R191R	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	313	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				TATCGGTCCCGTATTTCACAT	0.522			NA											12	205					7.03913e-09	1.28223e-08	0.001368	1	0
AP2S1	1175	broad.mit.edu	37	19	47342740	47342740	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:47342740G>A	uc002pft.1	-	3	429	c.249C>T	c.(247-249)GCC>GCT	p.A83A	AP2S1_uc002pfu.1_Intron	NM_004069	NP_004060	P53680	AP2S1_HUMAN	adaptor-related protein complex 2, sigma 1	83				A -> G (in Ref. 1; CAA65782 and 2; CAA09018).	axon guidance|clathrin coat assembly|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|regulation of endocytosis|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	protein transporter activity				0		all_cancers(25;1.24e-06)|all_epithelial(76;1.09e-05)|all_lung(116;0.00019)|Lung NSC(112;0.000601)|Ovarian(192;0.0221)|all_neural(266;0.0459)|Breast(70;0.128)		OV - Ovarian serous cystadenocarcinoma(262;3.86e-05)|all cancers(93;0.000107)|Epithelial(262;0.00325)|GBM - Glioblastoma multiforme(486;0.0336)		AGTTGTGAATGGCCTCCAGGT	0.582			NA											6	202					0	0	0.00308	0	0
ZNF765	91661	broad.mit.edu	37	19	53911926	53911926	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:53911926A>T	uc010ydx.1	+	6	1445	c.1118A>T	c.(1117-1119)CAT>CTT	p.H373L	ZNF765_uc002qbm.2_Missense_Mutation_p.H373L|ZNF765_uc002qbn.2_Intron	NM_001040185	NP_001035275	Q7L2R6	ZN765_HUMAN	zinc finger protein 765	373	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00379)		TTTACATGCCATCATAGAGTT	0.408			NA											7	185					0	0	0.001984	0	0
NLRP12	91662	broad.mit.edu	37	19	54299180	54299180	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:54299180C>T	uc002qch.3	-	9	3251	c.3031G>A	c.(3031-3033)GGG>AGG	p.G1011R	NLRP12_uc010eqw.2_Missense_Mutation_p.G237R|NLRP12_uc002qci.3_Missense_Mutation_p.G954R|NLRP12_uc002qcj.3_Missense_Mutation_p.G1012R|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	1011	LRR 7.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CCTGTGTCCCCTAGGGCGTTG	0.557			NA											4	40					0	0	0.001984	0	0
LILRB2	10288	broad.mit.edu	37	19	54783926	54783926	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:54783926G>T	uc002qfb.2	-	4	341	c.75C>A	c.(73-75)ACC>ACA	p.T25T	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Silent_p.T25T|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Silent_p.T25T|LILRB2_uc010yet.1_Intron|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	25	Extracellular (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCTTGGGAATGGTCCCTGGAA	0.582			NA											11	182					4.68919e-08	8.26729e-08	0.008291	1	0
NLRP8	126205	broad.mit.edu	37	19	56485017	56485017	+	Splice_Site	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr19:56485017G>C	uc002qmh.2	+	7	2606	c.2535_splice	c.e7-1	p.S845_splice	NLRP8_uc010etg.2_Intron	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8							cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CTCTCCCATAGGATAGAGAAC	0.517			NA											12	509					0	0	0.00245	0	0
SNTG2	54221	broad.mit.edu	37	2	1251123	1251123	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:1251123G>C	uc002qwq.2	+	12	1041	c.913G>C	c.(913-915)GAG>CAG	p.E305Q	SNTG2_uc010ewi.2_Missense_Mutation_p.E178Q	NM_018968	NP_061841	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	305	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			ovary(1)|large_intestine(1)|breast(1)	3	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		GTGGGTAAATGAGAAACTCCA	0.498			NA											6	61					0	0	0.001168	0	0
APOB	338	broad.mit.edu	37	2	21229397	21229397	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:21229397G>T	uc002red.2	-	26	10471	c.10343C>A	c.(10342-10344)ACC>AAC	p.T3448N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3448	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTTTGACTTGGTATTTCCATT	0.378			NA											22	302					4.54149e-19	9.7731e-19	0.002299	1	0
APOB	338	broad.mit.edu	37	2	21233785	21233785	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:21233785G>A	uc002red.2	-	26	6083	c.5955C>T	c.(5953-5955)ACC>ACT	p.T1985T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1985					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTTAAATTGGGTCTTGAGTT	0.463			NA											10	141					0	0	0.006214	0	0
STRN	6801	broad.mit.edu	37	2	37076763	37076763	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:37076763C>T	uc002rpn.2	-	18	2188	c.2179G>A	c.(2179-2181)GAC>AAC	p.D727N	STRN_uc010ezx.2_Missense_Mutation_p.D690N	NM_003162	NP_003153	O43815	STRN_HUMAN	striatin, calmodulin binding protein	727	WD 5.				dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			skin(1)	1		Ovarian(717;0.0129)|all_hematologic(82;0.21)				ATTGAACAGTCATGACCTATA	0.308			NA											5	88					0	0	0.001168	0	0
EML4	27436	broad.mit.edu	37	2	42515415	42515415	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:42515415C>G	uc002rsi.2	+	11	1433	c.1171C>G	c.(1171-1173)CTT>GTT	p.L391V	EML4_uc010fap.2_Missense_Mutation_p.L333V|EML4_uc002rsj.2_Missense_Mutation_p.L80V	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	391	WD 2.				microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						TGAGCATATGCTTACTGTATG	0.338			NA	T	ALK	NSCLC								5	131					0	0	0.001168	0	0
PSME4	23198	broad.mit.edu	37	2	54159167	54159167	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:54159167T>C	uc002rxp.2	-	10	1177	c.1121A>G	c.(1120-1122)AAG>AGG	p.K374R	PSME4_uc010yop.1_Missense_Mutation_p.K260R|PSME4_uc010yoq.1_RNA|PSME4_uc010fbu.1_5'UTR|PSME4_uc010fbv.1_Intron	NM_014614	NP_055429	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator	374					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			ovary(2)|breast(2)|pancreas(1)	5			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AGAGGGCTTCTTGTATCTTTC	0.418			NA											16	127					0	0	0.004007	0	0
ACYP2	98	broad.mit.edu	37	2	54365795	54365795	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:54365795G>C	uc002rxq.3	+	3	521	c.95G>C	c.(94-96)AGG>ACG	p.R32T		NM_138448	NP_612457	P14621	ACYP2_HUMAN	acylphosphatase 2	32	Acylphosphatase-like.				phosphate metabolic process		acylphosphatase activity				0						GATGAAGCTAGGAAAATAGGA	0.408			NA											6	59					0	0	0.001168	0	0
SPTBN1	6711	broad.mit.edu	37	2	54839363	54839363	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:54839363C>T	uc002rxu.2	+	4	615	c.366C>T	c.(364-366)TTC>TTT	p.F122F	SPTBN1_uc002rxv.1_Silent_p.F122F|SPTBN1_uc002rxx.2_Silent_p.F109F	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	122	CH 1.|Actin-binding.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CCCTTCAGTTCCTGAAGGAGC	0.537			NA											7	141					0	0	0.001984	0	0
USP34	9736	broad.mit.edu	37	2	61484357	61484357	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:61484357T>A	uc002sbe.2	-	45	5995	c.5973A>T	c.(5971-5973)GAA>GAT	p.E1991D	USP34_uc002sbf.2_Missense_Mutation_p.E141D	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	1991					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			GAGACATTTCTTCGATTTTGG	0.338			NA											14	129					0	0	0.003163	0	0
USP34	9736	broad.mit.edu	37	2	61566728	61566728	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:61566728C>G	uc002sbe.2	-	17	2611	c.2589G>C	c.(2587-2589)TTG>TTC	p.L863F		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	863					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CTATATCCCACAACAAAGTAT	0.303			NA											5	71					0	0	0.000602	0	0
ANTXR1	84168	broad.mit.edu	37	2	69304562	69304562	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:69304562A>C	uc002sfg.2	+	8	940	c.584A>C	c.(583-585)AAG>ACG	p.K195T	ANTXR1_uc002sfe.2_Missense_Mutation_p.K195T|ANTXR1_uc002sff.2_Missense_Mutation_p.K195T|ANTXR1_uc002sfd.2_Missense_Mutation_p.K195T	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	195	Extracellular (Potential).|VWFA.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						GCGGACAGTAAGGATCATGTG	0.498			NA							Familial_Infantile_Hemangioma				12	171					0	0	0.001855	0	0
DYSF	8291	broad.mit.edu	37	2	71795382	71795382	+	Silent	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:71795382G>C	uc002sie.2	+	26	3100	c.2724G>C	c.(2722-2724)ACG>ACC	p.T908T	DYSF_uc010feg.2_Silent_p.T939T|DYSF_uc010feh.2_Silent_p.T894T|DYSF_uc002sig.3_Silent_p.T894T|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.T908T|DYSF_uc010fef.2_Silent_p.T925T|DYSF_uc010fei.2_Silent_p.T925T|DYSF_uc010fek.2_Silent_p.T926T|DYSF_uc010fej.2_Silent_p.T895T|DYSF_uc010fel.2_Silent_p.T895T|DYSF_uc010feo.2_Silent_p.T940T|DYSF_uc010fem.2_Silent_p.T909T|DYSF_uc010fen.2_Silent_p.T926T|DYSF_uc002sif.2_Silent_p.T909T	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	908	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						CTGACGTCACGGGCAAGATCA	0.592			NA											23	412					0	0	0.003954	0	0
DCTN1	1639	broad.mit.edu	37	2	74593020	74593020	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:74593020C>T	uc002skx.2	-	24	3197	c.2886G>A	c.(2884-2886)AAG>AAA	p.K962K	SLC4A5_uc002skl.2_5'Flank|DCTN1_uc002skt.1_5'Flank|DCTN1_uc002skv.2_Silent_p.K828K|DCTN1_uc002sku.2_Silent_p.K828K|DCTN1_uc002skw.1_Silent_p.K938K|DCTN1_uc010ffd.2_Silent_p.K942K|DCTN1_uc002sky.2_Silent_p.K925K	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	962	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						CTACCCTCACCTTAATCTTGA	0.512			NA											14	207					0	0	0.003163	0	0
MRPL35	51318	broad.mit.edu	37	2	86433312	86433312	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:86433312A>C	uc002srg.3	+	2	185	c.127A>C	c.(127-129)ACT>CCT	p.T43P	MRPL35_uc002srf.3_Missense_Mutation_p.T43P	NM_016622	NP_057706	Q9NZE8	RM35_HUMAN	mitochondrial ribosomal protein L35 isoform a	43					translation	mitochondrial ribosome	structural constituent of ribosome				0						TGCATTGTCCACTGGACGTTT	0.458			NA											24	259					0	0	0.007291	0	0
RGPD4	285190	broad.mit.edu	37	2	108488728	108488728	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:108488728C>G	uc010ywk.1	+	20	4350	c.4268C>G	c.(4267-4269)ACA>AGA	p.T1423R	RGPD4_uc002tdu.2_Missense_Mutation_p.T610R|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1423	RanBD1 2.				intracellular transport		binding			skin(2)	2						ATGAAAGGGACAGAAAGAGTA	0.388			NA											55	462					0	0	0.00361	0	0
RANBP2	5903	broad.mit.edu	37	2	109371430	109371430	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:109371430G>A	uc002tem.3	+	16	2398	c.2272G>A	c.(2272-2274)GAA>AAA	p.E758K		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	758					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						AGACTATAGTGAAGGAGGTCC	0.378			NA											23	375					0	0	0.00632	0	0
BUB1	699	broad.mit.edu	37	2	111398671	111398671	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:111398671C>A	uc002tgc.2	-	23	3007	c.2895G>T	c.(2893-2895)AAG>AAT	p.K965N	BUB1_uc010yxh.1_Missense_Mutation_p.K945N|BUB1_uc010fkb.2_Missense_Mutation_p.K908N	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	965	Protein kinase.				apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		ATGTTTCACACTTTGCTGTGA	0.383			NA											19	170					1.56452e-12	3.1651e-12	0.007413	1	0
DPP10	57628	broad.mit.edu	37	2	116525883	116525883	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:116525883C>A	uc002tla.1	+	13	1581	c.1124C>A	c.(1123-1125)CCC>CAC	p.P375H	DPP10_uc002tlb.1_Missense_Mutation_p.P325H|DPP10_uc002tlc.1_Missense_Mutation_p.P371H|DPP10_uc002tle.2_Missense_Mutation_p.P379H|DPP10_uc002tlf.1_Missense_Mutation_p.P368H	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	375	Extracellular (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						AATGAGGAGCCCGTGTTTTCT	0.448			NA											10	74					0.000673444	0.000835147	0.008291	1	0
GLI2	2736	broad.mit.edu	37	2	121743871	121743871	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:121743871C>T	uc010flp.2	+	12	2004	c.1974C>T	c.(1972-1974)CCC>CCT	p.P658P	GLI2_uc002tmq.1_Silent_p.P330P|GLI2_uc002tmr.1_Silent_p.P313P|GLI2_uc002tmt.3_Silent_p.P330P|GLI2_uc002tmu.3_Silent_p.P313P|GLI2_uc002tmw.1_Silent_p.P641P	NM_005270	NP_005261	P10070	GLI2_HUMAN	GLI-Kruppel family member GLI2	658					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|lung(2)|breast(1)|central_nervous_system(1)|pancreas(1)	13	Renal(3;0.0496)	Prostate(154;0.0623)				AGTCCAGCCCCGGGGCCCAGT	0.667			NA											4	29					0	0	0.000602	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542273	133542273	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:133542273C>A	uc002ttp.2	-	14	2485	c.2111G>T	c.(2110-2112)GGA>GTA	p.G704V	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	704							protein binding				0						TGCCTTGGGTCCAGCAGGAGT	0.453			NA											11	190					5.16669e-11	9.99196e-11	0.000978	1	0
LRP1B	53353	broad.mit.edu	37	2	141135856	141135856	+	Splice_Site	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:141135856C>G	uc002tvj.1	-	68	11504	c.10532_splice	c.e68-1	p.K3511_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTCTGTGGCTCTGGGGATAAA	0.368	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			6	38					0	0	0.001168	0	0
CYTIP	9595	broad.mit.edu	37	2	158272583	158272583	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:158272583C>A	uc002tzj.1	-	8	758	c.686G>T	c.(685-687)GGG>GTG	p.G229V	CYTIP_uc010zcl.1_Missense_Mutation_p.G123V	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	229					regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						TGGGCCTGGCCCAGGCAGGGG	0.517			NA											5	89					3.59834e-05	5.19628e-05	0.001168	1	0
XIRP2	129446	broad.mit.edu	37	2	168102024	168102024	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:168102024C>A	uc002udx.2	+	8	4140	c.4122C>A	c.(4120-4122)GTC>GTA	p.V1374V	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Silent_p.V1199V|XIRP2_uc010fpq.2_Silent_p.V1152V|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1199					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTAAATCTGTCACACAAGAAG	0.358			NA											9	112					0.000274275	0.000355182	0.004482	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803228	185803228	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:185803228G>T	uc002uph.2	+	4	3699	c.3105G>T	c.(3103-3105)TTG>TTT	p.L1035F		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1035						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AAGCATTATTGATCCCACTAG	0.413			NA											9	147					6.40141e-05	8.97834e-05	0.000978	1	0
COL5A2	1290	broad.mit.edu	37	2	189904125	189904125	+	Silent	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:189904125T>A	uc002uqk.2	-	51	4073	c.3798A>T	c.(3796-3798)CCA>CCT	p.P1266P	COL5A2_uc010frx.2_Silent_p.P842P	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1266	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CATGAACCCCTGGGTCCGTTT	0.512			NA											4	54					0	0	0.000248	0	0
CD28	940	broad.mit.edu	37	2	204591409	204591409	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:204591409G>T	uc002vah.3	+	2	328	c.106G>T	c.(106-108)GTC>TTC	p.V36F	CD28_uc002vag.1_RNA|CD28_uc010zio.1_RNA|CD28_uc010ftx.2_Intron|CD28_uc002vaj.3_RNA	NM_006139	NP_006130	P10747	CD28_HUMAN	CD28 antigen precursor	36	Extracellular (Potential).|Ig-like V-type.				cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity				0						CGACAATGCGGTCAACCTTAG	0.433			NA											11	139					1.08611e-07	1.85526e-07	0.000978	1	0
GPR1	2825	broad.mit.edu	37	2	207041255	207041255	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:207041255C>A	uc002vbl.3	-	3	1103	c.717G>T	c.(715-717)CTG>CTT	p.L239L	GPR1_uc010fue.2_Silent_p.L239L|GPR1_uc010fuf.2_Silent_p.L239L	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	239	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		TACTGGAGATCAGGATGCTTC	0.438			NA											7	77					0.00307968	0.00362461	0.00308	1	0
DYTN	391475	broad.mit.edu	37	2	207564941	207564941	+	Splice_Site	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:207564941C>A	uc002vbr.1	-	6	601	c.484_splice	c.e6-1	p.I162_splice		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin							plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		AAGTTGGGATCTGCAAGAGAC	0.552			NA											7	90					2.0095e-06	3.24327e-06	0.001984	1	0
MARCH4	57574	broad.mit.edu	37	2	217124066	217124066	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:217124066C>T	uc002vgb.2	-	4	2969	c.1202G>A	c.(1201-1203)CGA>CAA	p.R401Q		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	401						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GACCAGCTCTCGGCTGCTGCC	0.612			NA											5	99					0	0	0.000602	0	0
PRKAG3	53632	broad.mit.edu	37	2	219695055	219695055	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:219695055G>A	uc002vjb.1	-	4	298	c.279C>T	c.(277-279)TTC>TTT	p.F93F	PRKAG3_uc010zkn.1_RNA|PRKAG3_uc010fvy.1_Silent_p.F93F|PRKAG3_uc010zko.1_Silent_p.F89F	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	93					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGGTCTTGGGGAATGTGGCCT	0.632			NA											5	42					0	0	0.00308	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882479	228882479	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:228882479C>A	uc002vpq.2	-	7	3138	c.3091G>T	c.(3091-3093)GTC>TTC	p.V1031F	SPHKAP_uc002vpp.2_Missense_Mutation_p.V1031F|SPHKAP_uc010zlx.1_Missense_Mutation_p.V1031F	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1031						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GAATCTGGGACATCTTCAAGG	0.507			NA											13	187					1.05317e-09	1.97582e-09	0.00245	1	0
SAG	6295	broad.mit.edu	37	2	234227423	234227423	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:234227423C>A	uc002vuh.2	+	4	551	c.163C>A	c.(163-165)CTT>ATT	p.L55I	SAG_uc002vug.2_RNA|SAG_uc010zmq.1_5'UTR	NM_000541	NP_000532	P10523	ARRS_HUMAN	S-arrestin	55					rhodopsin mediated phototransduction|rhodopsin mediated signaling pathway		protein phosphatase inhibitor activity			ovary(1)	1		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.018)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.054)		Epithelial(121;2.86e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00608)|Lung(119;0.00714)|GBM - Glioblastoma multiforme(43;0.207)		TGATCCTGATCTTGTGAAGGG	0.512			NA											14	158					2.31682e-05	3.44775e-05	0.003163	1	0
DNAJB3	414061	broad.mit.edu	37	2	234652384	234652384	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:234652384T>C	uc002vuz.2	-	1	278	c.179A>G	c.(178-180)AAG>AGG	p.K60R	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Intron|UGT1A10_uc002vur.2_Intron|UGT1A9_uc010zmw.1_Intron|UGT1A9_uc002vus.2_Intron|UGT1A7_uc010zmx.1_Intron|UGT1A7_uc002vut.2_Intron|UGT1A6_uc002vuu.2_Intron|UGT1A6_uc010zmy.1_Intron|UGT1A6_uc002vuv.3_Intron|UGT1A5_uc010zmz.1_Intron|UGT1A5_uc002vuw.2_Intron|UGT1A4_uc010zna.1_Intron|UGT1A4_uc002vux.2_Intron|UGT1A3_uc010znb.1_Intron|UGT1A3_uc002vuy.2_Intron	NM_001001394	NP_001001394	Q8WWF6	DNJB3_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 3	60	J.				protein folding		heat shock protein binding|unfolded protein binding				0						ATCGCGTTTCTTGGCGTCCGA	0.622			NA											11	167					0	0	0.001368	0	0
HDAC4	9759	broad.mit.edu	37	2	239976512	239976512	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:239976512T>A	uc002vyk.3	-	25	3798	c.3006A>T	c.(3004-3006)GAA>GAT	p.E1002D	HDAC4_uc010fyy.2_Missense_Mutation_p.E959D	NM_006037	NP_006028	P56524	HDAC4_HUMAN	histone deacetylase 4	1002	Histone deacetylase.				B cell differentiation|cardiac muscle hypertrophy in response to stress|chromatin remodeling|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of glycolysis|negative regulation of myotube differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nervous system development|peptidyl-lysine deacetylation|positive regulation of cell proliferation|positive regulation of protein sumoylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|response to denervation involved in regulation of muscle adaptation|response to interleukin-1|transcription, DNA-dependent	histone deacetylase complex|transcriptional repressor complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|potassium ion binding|repressing transcription factor binding|zinc ion binding			breast(3)|skin(2)|ovary(1)	6		all_epithelial(40;1.45e-17)|Breast(86;1.53e-05)|Renal(207;0.000355)|all_lung(227;0.0121)|Ovarian(221;0.0183)|Lung NSC(271;0.0413)|Melanoma(123;0.0749)|all_hematologic(139;0.159)		Epithelial(121;6.38e-25)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-12)|Kidney(56;6.04e-08)|KIRC - Kidney renal clear cell carcinoma(57;1.18e-06)|BRCA - Breast invasive adenocarcinoma(100;3.99e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.04)		GTAAAACCTTTTCTGGGAGAG	0.473			NA											12	130					0	0	0.001855	0	0
KIF16B	55614	broad.mit.edu	37	20	16355030	16355030	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr20:16355030C>A	uc002wpg.1	-	20	3380	c.3222G>T	c.(3220-3222)CTG>CTT	p.L1074L	KIF16B_uc002wpe.1_Silent_p.L456L|KIF16B_uc002wpf.1_Silent_p.L456L|KIF16B_uc010gch.1_Intron|KIF16B_uc010gci.1_Silent_p.L1074L	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	1074	Potential.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TCTTCTGTTTCAGCTGCTGGA	0.323			NA											8	149					0.00448238	0.00523342	0.004482	1	0
EMILIN3	90187	broad.mit.edu	37	20	39992319	39992319	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr20:39992319G>T	uc002xjy.1	-	3	697	c.473C>A	c.(472-474)CCC>CAC	p.P158H		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	158						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				AGGGGGCCTGGGGCCTGGGTC	0.647			NA											4	64					0.000602214	0.000753197	0.000602	1	0
PTPRT	11122	broad.mit.edu	37	20	40748573	40748573	+	Splice_Site	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr20:40748573A>T	uc002xkg.2	-	20	3068	c.2884_splice	c.e20+1	p.G962_splice	PTPRT_uc010ggj.2_Splice_Site_p.G981_splice|PTPRT_uc010ggi.2_Splice_Site_p.G165_splice	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T						homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GAGGGCACTTACCTTGAGTCG	0.512			NA											14	172					0	0	0.003163	0	0
MYBL2	4605	broad.mit.edu	37	20	42331360	42331361	+	Missense_Mutation	DNP	CA	CA	TT			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr20:42331360_42331361CA>TT	uc002xlb.1	+	8	1397_1398	c.1182_1183CA>TT	c.(1180-1185)CCCAGC>CCTTGC	p.S395C	MYBL2_uc010zwj.1_Missense_Mutation_p.S371C|MYBL2_uc002xla.1_Missense_Mutation_p.S395C	NM_002466	NP_002457	P10244	MYBB_HUMAN	MYB-related protein B	395						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(3)|kidney(2)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			CCATCTCCCCCAGCACTGAAGT	0.649			NA											6	62					0	0	0.004672	0	0
BMP7	655	broad.mit.edu	37	20	55803312	55803312	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr20:55803312T>C	uc010gip.1	-	2	1113	c.584A>G	c.(583-585)TAT>TGT	p.Y195C	BMP7_uc010giq.1_Missense_Mutation_p.Y195C|BMP7_uc002xyc.2_Missense_Mutation_p.Y195C	NM_001719	NP_001710	P18075	BMP7_HUMAN	bone morphogenetic protein 7 precursor	195					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			skin(1)	1	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			GAGCACCTGATAAACGCTGAT	0.572			NA											9	239					0	0	0.008291	0	0
STX16	8675	broad.mit.edu	37	20	57245566	57245566	+	Splice_Site	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr20:57245566A>C	uc002xzi.2	+	6	1292	c.557_splice	c.e6-2	p.R186_splice	STX16_uc010zzq.1_Splice_Site|STX16_uc002xzk.2_Splice_Site_p.R169_splice|STX16_uc002xzm.2_Splice_Site_p.R182_splice|STX16_uc002xzj.2_Splice_Site_p.R165_splice|STX16_uc002xzl.2_Splice_Site	NM_001001433	NP_001001433	O14662	STX16_HUMAN	syntaxin 16 isoform a						intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			ovary(1)	1	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			TATCTGTGATAGGCATGAAGA	0.388			NA											3	82					0	0	0.004672	0	0
LIPI	149998	broad.mit.edu	37	21	15537620	15537620	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:15537620A>T	uc002yjm.2	-	6	898	c.888T>A	c.(886-888)TGT>TGA	p.C296*	LIPI_uc010gkw.1_Nonsense_Mutation_p.C199*	NM_198996	NP_945347	Q6XZB0	LIPI_HUMAN	lipase, member I	275					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			ovary(2)	2				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TGTATGAACGACAAGGAAATG	0.358			NA											11	99					0	0	0.008291	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28306829	28306829	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:28306829G>T	uc002ymg.2	-	4	2374	c.1645C>A	c.(1645-1647)CTG>ATG	p.L549M		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	549	Disintegrin.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TTGCCCTGCAGGCAGATTCTC	0.507	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											8	137					0.000274275	0.000355182	0.004482	1	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692128	31692128	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:31692128G>T	uc002ynw.2	-	1	480	c.226C>A	c.(226-228)CTT>ATT	p.L76I		NM_203405	NP_981950	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	76						intermediate filament				ovary(1)	1						GAGGTTTCAAGATTGCCGGTC	0.547			NA											13	125					8.60227e-14	1.78976e-13	0.004007	1	0
KRTAP19-3	337970	broad.mit.edu	37	21	31864089	31864089	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:31864089C>A	uc002yog.1	-	1	187	c.187G>T	c.(187-189)GGA>TGA	p.G63*		NM_181609	NP_853640	Q7Z4W3	KR193_HUMAN	keratin associated protein 19-3	63						intermediate filament					0						CAGCCATATCCGTAGCCTCCG	0.502			NA											6	122					0.000978159	0.00120621	0.000978	1	0
MORC3	23515	broad.mit.edu	37	21	37741309	37741309	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:37741309G>T	uc002yvi.2	+	15	1719	c.1643G>T	c.(1642-1644)CGT>CTT	p.R548L		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	548					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						CTTTCTACTCGTTCCTCAATT	0.294			NA											7	46					8.12818e-05	0.000111161	0.001984	1	0
TRAPPC10	7109	broad.mit.edu	37	21	45522849	45522849	+	Silent	SNP	C	C	T	rs146580471		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:45522849C>T	uc002zea.2	+	22	3706	c.3537C>T	c.(3535-3537)GAC>GAT	p.D1179D	TRAPPC10_uc010gpo.2_Silent_p.D890D|TRAPPC10_uc011afa.1_Silent_p.D557D	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	1179					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CCCAACTGGACGCTGGTAAGG	0.512			NA											3	71					0	0	0.004672	0	0
KRTAP10-10	353333	broad.mit.edu	37	21	46057462	46057462	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr21:46057462C>A	uc002zfq.2	+	1	190	c.128C>A	c.(127-129)ACC>AAC	p.T43N	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_181688	NP_859016	P60014	KR10A_HUMAN	keratin associated protein 10-10	43	15 X 5 AA repeats of C-C-X(3).					keratin filament					0						CTGGTCTGCACCCCAGTGAGC	0.662			NA											3	38					3.59834e-05	5.19628e-05	0.001168	1	0
PPIL2	23759	broad.mit.edu	37	22	22035675	22035675	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr22:22035675A>G	uc010gtj.1	+	7	499	c.383A>G	c.(382-384)TAT>TGT	p.Y128C	PPIL2_uc002zvh.3_Missense_Mutation_p.Y128C|PPIL2_uc002zvi.3_Missense_Mutation_p.Y128C|PPIL2_uc002zvg.3_Missense_Mutation_p.Y128C|PPIL2_uc011aij.1_Missense_Mutation_p.Y107C	NM_148175	NP_680480	Q13356	PPIL2_HUMAN	peptidylprolyl isomerase-like 2 isoform a	128					blood coagulation|leukocyte migration|protein folding|protein polyubiquitination	Golgi lumen|nucleus|ubiquitin ligase complex	peptidyl-prolyl cis-trans isomerase activity|ubiquitin-ubiquitin ligase activity			ovary(2)	2	Colorectal(54;0.105)					GTCTACGCCTATGAGGTGTGT	0.587			NA											3	44					0	0	0.004672	0	0
C22orf30	253143	broad.mit.edu	37	22	32108284	32108284	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr22:32108284G>T	uc003alp.3	-	4	5734	c.5541C>A	c.(5539-5541)ACC>ACA	p.T1847T	C22orf30_uc003alo.1_Silent_p.T1646T|C22orf30_uc010gwj.1_Silent_p.T1646T	NM_173566	NP_775837	Q5THK1	PR14L_HUMAN	hypothetical protein LOC253143	1847											0						GCCTCTGCATGGTAGGCATGT	0.522			NA											6	94					0.00307968	0.00362461	0.00308	1	0
CNTN4	152330	broad.mit.edu	37	3	2942376	2942376	+	Silent	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:2942376T>A	uc003bpc.2	+	10	1169	c.948T>A	c.(946-948)CCT>CCA	p.P316P	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Silent_p.P316P|CNTN4_uc003bpe.2_5'UTR|CNTN4_uc003bpf.2_5'UTR	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	316	Ig-like C2-type 4.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TAGCTCAACCTAATTGGATTC	0.348			NA											4	149					0	0	0.000248	0	0
KIF9	64147	broad.mit.edu	37	3	47289507	47289507	+	Splice_Site	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:47289507C>A	uc010hjp.2	-	12	1732	c.1128_splice	c.e12+1	p.L376_splice	KIF9_uc003cqx.2_Splice_Site_p.L376_splice|KIF9_uc003cqy.2_Splice_Site_p.L376_splice|KIF9_uc011bat.1_Splice_Site|KIF9_uc011bau.1_Splice_Site	NM_001134878	NP_001128350	Q9HAQ2	KIF9_HUMAN	kinesin family member 9 isoform 2						blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(1)	1		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		TAGCCTCTTACCAGGCTGTCA	0.577	Colon(44;962 1147 15977 24541)		NA											18	168					2.44723e-14	5.11588e-14	0.004656	1	0
OR5K1	26339	broad.mit.edu	37	3	98188903	98188903	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:98188903G>T	uc003dsm.2	+	1	483	c.483G>T	c.(481-483)GGG>GGT	p.G161G		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	161	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TTCATGTAGGGCTTGTATTTA	0.418			NA											11	375					0.00829132	0.00962933	0.008291	1	0
IGSF11	152404	broad.mit.edu	37	3	118623644	118623644	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:118623644G>A	uc003ebw.2	-	6	952	c.705C>T	c.(703-705)CCC>CCT	p.P235P	IGSF11_uc011biv.1_Intron|IGSF11_uc003ebx.2_Silent_p.A211A|IGSF11_uc003eby.2_Silent_p.P234P|IGSF11_uc003ebz.2_Silent_p.A210A|IGSF11_uc010hqs.2_Silent_p.P234P	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	235	Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						TCCTGGGCTGGGCTGCAAAAT	0.348			NA											17	195					0	0	0.004007	0	0
PARP9	83666	broad.mit.edu	37	3	122274537	122274537	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:122274537C>A	uc010hri.2	-	4	731	c.586G>T	c.(586-588)GCT>TCT	p.A196S	PARP9_uc003eff.3_Missense_Mutation_p.A161S|PARP9_uc011bjs.1_Missense_Mutation_p.A161S|PARP9_uc003efg.2_Intron|PARP9_uc003efi.2_Missense_Mutation_p.A161S|PARP9_uc003efh.2_Missense_Mutation_p.A196S|PARP9_uc003efj.2_Missense_Mutation_p.A161S	NM_001146102	NP_001139574	Q8IXQ6	PARP9_HUMAN	poly (ADP-ribose) polymerase family, member 9	196	Macro 1.				cell migration	cytosol|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)|pancreas(1)|prostate(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0519)		GGCCCAACAGCATGGATGATC	0.463			NA											4	58					0.00024832	0.000326385	0.000248	1	0
RHO	6010	broad.mit.edu	37	3	129251250	129251250	+	Silent	SNP	C	C	A	rs143003934		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:129251250C>A	uc003emt.2	+	3	782	c.687C>A	c.(685-687)ACC>ACA	p.T229T		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	229	Helical; Name=5; (Potential).				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	TCGTCTTCACCGTCAAGGAGG	0.592	Esophageal Squamous(118;214 1623 30842 43234 46940)		NA											9	99					3.86212e-05	5.52271e-05	0.008291	1	0
CLRN1	7401	broad.mit.edu	37	3	150690263	150690263	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:150690263G>C	uc003eyk.1	-	1	524	c.233C>G	c.(232-234)GCA>GGA	p.A78G	CLRN1OS_uc011bny.1_Intron|CLRN1OS_uc003eyl.2_5'Flank	NM_174878	NP_777367	P58418	CLRN1_HUMAN	clarin 1 isoform a	78					equilibrioception|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	integral to membrane					0			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			AAAGGGCCTTGCTCCCAACCC	0.478			NA											5	92					0	0	0.001168	0	0
PPM1L	151742	broad.mit.edu	37	3	160474182	160474182	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:160474182T>C	uc003fdr.2	+	1	187	c.86T>C	c.(85-87)CTG>CCG	p.L29P		NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	29	Helical; (Potential).				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			CTTTTCCTGCTGTGCATCAGC	0.517	Pancreas(86;250 1994 13715 43211)		NA											16	88					0	0	0.007413	0	0
SI	6476	broad.mit.edu	37	3	164709251	164709251	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:164709251G>T	uc003fei.2	-	44	5060	c.4998C>A	c.(4996-4998)GGC>GGA	p.G1666G		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1666	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTCCTCTGACGCCAATATCTT	0.403			NA								HNSCC(35;0.089)			8	66					0.000157383	0.000210004	0.00308	1	0
HTR3E	285242	broad.mit.edu	37	3	183822012	183822012	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:183822012G>A	uc010hxq.2	+	4	788	c.322G>A	c.(322-324)GAG>AAG	p.E108K	HTR3E_uc003fml.3_Missense_Mutation_p.E93K|HTR3E_uc003fmm.2_Missense_Mutation_p.E123K|HTR3E_uc010hxr.2_Missense_Mutation_p.E108K|HTR3E_uc003fmn.2_Missense_Mutation_p.E108K	NM_182589	NP_872395	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine receptor 3 subunit E	108	Extracellular (Potential).					integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			AGAGGAATGTGAGGGCATCAC	0.483	Melanoma(7;227 727 6634 44770)		NA											3	36					0	0	0.000602	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2321937	2321937	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:2321937C>G	uc003gex.1	-	7	1082	c.763G>C	c.(763-765)GAG>CAG	p.E255Q	ZFYVE28_uc011bvk.1_Missense_Mutation_p.E185Q|ZFYVE28_uc011bvl.1_Missense_Mutation_p.E225Q|ZFYVE28_uc003gew.1_Missense_Mutation_p.E141Q	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	255					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						CGGAACAGCTCGGACATGTCT	0.607			NA											7	47					0	0	0.00308	0	0
EVC2	132884	broad.mit.edu	37	4	5693029	5693029	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:5693029G>A	uc003gij.2	-	4	536	c.482C>T	c.(481-483)ACT>ATT	p.T161I	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.T81I	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	161						integral to membrane				large_intestine(3)|ovary(2)	5						ATTTTCAGAAGTCCCTTGAAC	0.299			NA											5	147					0	0	0.001168	0	0
PPEF2	5470	broad.mit.edu	37	4	76797517	76797517	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:76797517C>A	uc003hix.2	-	11	1600	c.1243G>T	c.(1243-1245)GAG>TAG	p.E415*	PPEF2_uc003hiy.2_RNA|PPEF2_uc003hiz.1_Nonsense_Mutation_p.E415*	NM_006239	NP_006230	O14830	PPE2_HUMAN	serine/threonine protein phosphatase with	415	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			ovary(2)|lung(1)|central_nervous_system(1)	4			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			CGGGAGGGCTCCTCTTTCTCT	0.677	NSCLC(105;1359 1603 15961 44567 47947)		NA											10	67					3.07112e-06	4.88486e-06	0.000978	1	0
MRPL1	65008	broad.mit.edu	37	4	78830509	78830509	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:78830509C>T	uc003hku.2	+	7	958	c.760C>T	c.(760-762)CAG>TAG	p.Q254*	MRPL1_uc010iji.1_Nonsense_Mutation_p.Q177*	NM_020236	NP_064621	Q9BYD6	RM01_HUMAN	mitochondrial ribosomal protein L1 precursor	254							RNA binding				0						GAACTTTCTCCAGACCAAAAT	0.294			NA											7	133					0	0	0.001984	0	0
UBE2D3	7323	broad.mit.edu	37	4	103723775	103723775	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:103723775G>A	uc003hwk.2	-	5	602	c.141C>T	c.(139-141)GGC>GGT	p.G47G	UBE2D3_uc003hwi.2_Silent_p.G47G|UBE2D3_uc003hwj.2_RNA|UBE2D3_uc003hwl.2_Silent_p.G47G|UBE2D3_uc011cet.1_Silent_p.G47G|UBE2D3_uc011ceu.1_Silent_p.G47G|UBE2D3_uc003hwo.2_Silent_p.G47G|UBE2D3_uc003hwp.2_Silent_p.G47G|UBE2D3_uc003hwq.2_Silent_p.G49G|UBE2D3_uc003hwr.2_Silent_p.G47G	NM_181887	NP_871616	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3 isoform 1	47					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		AGAATACACCGCCTTGATATG	0.323			NA											6	133					0	0	0.001168	0	0
NHEDC1	150159	broad.mit.edu	37	4	103910990	103910990	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:103910990G>C	uc003hww.2	-	3	300	c.178C>G	c.(178-180)CTA>GTA	p.L60V	NHEDC1_uc003hwu.2_Missense_Mutation_p.L60V|NHEDC1_uc010ilm.2_5'UTR|NHEDC1_uc003hwv.2_RNA|NHEDC1_uc011cev.1_Intron	NM_139173	NP_631912	Q4ZJI4	NHDC1_HUMAN	Na+/H+ exchanger domain containing 1 isoform 1	60						integral to membrane	solute:hydrogen antiporter activity			ovary(1)|skin(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;1.5e-08)		ACTCCTCTTAGAGGACAAGAA	0.284			NA											11	53					0	0	0.008291	0	0
ANK2	287	broad.mit.edu	37	4	114177071	114177071	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:114177071C>A	uc003ibe.3	+	11	1271	c.1171C>A	c.(1171-1173)CCG>ACG	p.P391T	ANK2_uc003ibd.3_Missense_Mutation_p.P370T|ANK2_uc003ibf.3_Missense_Mutation_p.P391T|ANK2_uc003ibc.2_Missense_Mutation_p.P367T|ANK2_uc011cgb.1_Missense_Mutation_p.P406T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	391	ANK 11.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGAGCCAATCCGAACGCCAG	0.493			NA											8	120					0.000442599	0.000564829	0.006214	1	0
TMEM144	55314	broad.mit.edu	37	4	159162701	159162701	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:159162701T>G	uc003ipx.2	+	11	1363	c.843T>G	c.(841-843)TGT>TGG	p.C281W	TMEM144_uc010iqi.2_RNA	NM_018342	NP_060812	Q7Z5S9	TM144_HUMAN	transmembrane protein 144	281	Helical; (Potential).					integral to membrane					0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0539)		CTACCTGCTGTTGGTTCATAG	0.408			NA											27	273					0	0	0.001786	0	0
DDX60L	91351	broad.mit.edu	37	4	169300609	169300609	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:169300609G>A	uc003irq.3	-	32	4489	c.4268C>T	c.(4267-4269)GCA>GTA	p.A1423V		NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1423							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CAAATATGATGCAAGTCCTGC	0.328			NA											7	48					0	0	0.001984	0	0
MFAP3L	9848	broad.mit.edu	37	4	170912688	170912688	+	Silent	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:170912688T>A	uc003isp.3	-	3	1249	c.1071A>T	c.(1069-1071)GCA>GCT	p.A357A	MFAP3L_uc003isn.3_Silent_p.A254A	NM_021647	NP_067679	O75121	MFA3L_HUMAN	microfibrillar-associated protein 3-like isoform	357	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|all_neural(102;0.122)|Melanoma(52;0.17)		GBM - Glioblastoma multiforme(119;0.0201)|LUSC - Lung squamous cell carcinoma(193;0.116)		TAGAAGGTTCTGCAGTTTCGG	0.507			NA											9	136					0	0	0.004482	0	0
LOC285501	285501	broad.mit.edu	37	4	178896957	178896957	+	Splice_Site	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:178896957G>C	uc010iru.2	+	5		c.627_splice	c.e5-1			NR_028342				Homo sapiens cDNA clone IMAGE:4828874.												0		all_lung(41;6.03e-08)|Lung NSC(41;4.26e-07)|Breast(14;0.00066)|Melanoma(52;0.00168)|Prostate(90;0.0129)|all_hematologic(60;0.0202)|Renal(120;0.0246)|Colorectal(36;0.0508)|Hepatocellular(41;0.236)		all cancers(43;9.24e-25)|Epithelial(43;6.28e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.29e-10)|LUSC - Lung squamous cell carcinoma(1;2.61e-05)|Lung(1;3.22e-05)|GBM - Glioblastoma multiforme(59;0.000185)|Colorectal(24;0.000244)|STAD - Stomach adenocarcinoma(60;0.000777)|COAD - Colon adenocarcinoma(29;0.000884)		TCTTTTCTTAGGAGAGAAGAC	0.423			NA											10	124					0	0	0.006214	0	0
F11	2160	broad.mit.edu	37	4	187201386	187201386	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr4:187201386A>G	uc003iza.1	+	9	1208	c.875A>G	c.(874-876)CAT>CGT	p.H292R		NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	292	Apple 4.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GTGTTCTGCCATTCTTCATTT	0.502			NA											16	209					0	0	0.006122	0	0
MARCH6	10299	broad.mit.edu	37	5	10410252	10410252	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:10410252G>A	uc003jet.1	+	18	1738	c.1555G>A	c.(1555-1557)GAT>AAT	p.D519N	MARCH6_uc011cmu.1_Missense_Mutation_p.D471N|MARCH6_uc003jeu.1_Missense_Mutation_p.D217N|MARCH6_uc011cmv.1_Missense_Mutation_p.D414N	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	519	Extracellular (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						CTCTTTCAGTGATGCTCCAGT	0.378			NA											54	200					0	0	0.00361	0	0
PRDM9	56979	broad.mit.edu	37	5	23522766	23522766	+	Silent	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:23522766C>G	uc003jgo.2	+	8	836	c.654C>G	c.(652-654)GCC>GCG	p.A218A		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	218					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GCTGTGCTGCCCATGGGCCCC	0.512			NA								HNSCC(3;0.000094)			15	63					0	0	0.004007	0	0
CDH9	1007	broad.mit.edu	37	5	26906121	26906121	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:26906121G>T	uc003jgs.1	-	5	927	c.758C>A	c.(757-759)ACA>AAA	p.T253K	CDH9_uc010iug.2_Missense_Mutation_p.T253K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	253	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GATGTTCACTGTGGTGGTTCC	0.458	Melanoma(8;187 585 15745 40864 52829)		NA											19	301					7.07596e-05	9.89282e-05	0.006122	1	0
NPR3	4883	broad.mit.edu	37	5	32786366	32786366	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:32786366G>T	uc003jhv.2	+	8	1759	c.1541G>T	c.(1540-1542)AGG>ATG	p.R514M	NPR3_uc011cnz.1_Missense_Mutation_p.R297M|NPR3_uc003jhu.2_Missense_Mutation_p.R513M|C5orf23_uc003jhw.1_5'Flank	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	514	Cytoplasmic (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	ACCATTGAGAGGCGAACCCAG	0.418			NA											6	12					0.00198382	0.00237301	0.001984	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33546167	33546167	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:33546167G>T	uc003jia.1	-	22	4606	c.4443C>A	c.(4441-4443)GAC>GAA	p.D1481E	ADAMTS12_uc010iuq.1_Missense_Mutation_p.D1396E	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1481	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GTCTTACCAGGTCCCAGTTCC	0.333			NA								HNSCC(64;0.19)			11	144					2.80697e-09	5.17757e-09	0.000978	1	0
RAI14	26064	broad.mit.edu	37	5	34823639	34823639	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:34823639G>T	uc003jir.2	+	15	1888	c.1692G>T	c.(1690-1692)GAG>GAT	p.E564D	RAI14_uc010iur.2_Missense_Mutation_p.E535D|RAI14_uc011coj.1_Missense_Mutation_p.E564D|RAI14_uc003jis.2_Missense_Mutation_p.E567D|RAI14_uc003jit.2_Missense_Mutation_p.E564D|RAI14_uc011cok.1_Missense_Mutation_p.E556D	NM_015577	NP_056392	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14 isoform a	564	Potential.					cell cortex|cytoskeleton	protein binding			ovary(1)	1	all_lung(31;0.000191)					tagagagggagaaagGTACAG	0.239			NA											8	101					1.26484e-09	2.35283e-09	0.00308	1	0
NIPBL	25836	broad.mit.edu	37	5	36955648	36955648	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:36955648G>C	uc003jkl.3	+	3	638	c.139G>C	c.(139-141)GCA>CCA	p.A47P	NIPBL_uc003jkk.3_Missense_Mutation_p.A47P	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	47					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TGCACGAATAGCAGAAGAGGT	0.413			NA											60	172					0	0	0.00361	0	0
NIPBL	25836	broad.mit.edu	37	5	37049220	37049220	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:37049220A>T	uc003jkl.3	+	40	7270	c.6771A>T	c.(6769-6771)AAA>AAT	p.K2257N	NIPBL_uc003jkk.3_Missense_Mutation_p.K2257N|NIPBL_uc003jkn.2_5'Flank	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	2257	HEAT 4.				brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TAGGGAAGAAAGTTGCAAAAC	0.358			NA											23	239					0	0	0.00333	0	0
FYB	2533	broad.mit.edu	37	5	39134975	39134975	+	Silent	SNP	T	T	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:39134975T>G	uc003jls.2	-	7	1724	c.1657A>C	c.(1657-1659)AGA>CGA	p.R553R	FYB_uc003jlt.2_Silent_p.R553R|FYB_uc003jlu.2_Silent_p.R553R|FYB_uc011cpl.1_Silent_p.R563R	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	553	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			CTTGCTGTTCTGCCCAACCAT	0.423			NA											14	110					0	0	0.00245	0	0
ZNF366	167465	broad.mit.edu	37	5	71756814	71756814	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:71756814C>A	uc003kce.1	-	2	696	c.510G>T	c.(508-510)CTG>CTT	p.L170L		NM_152625	NP_689838	Q8N895	ZN366_HUMAN	zinc finger protein 366	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2		Lung NSC(167;0.0247)|Ovarian(174;0.0908)|Prostate(461;0.155)		OV - Ovarian serous cystadenocarcinoma(47;2.51e-53)		AGGGCGTGGGCAGGAATGGAG	0.637			NA											13	107					0.000308642	0.000398511	0.003163	1	0
FAM169A	26049	broad.mit.edu	37	5	74100403	74100403	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:74100403G>T	uc003kdm.2	-	8	870	c.827C>A	c.(826-828)CCT>CAT	p.P276H	FAM169A_uc010izm.2_Missense_Mutation_p.P216H|FAM169A_uc003kdl.2_Missense_Mutation_p.P94H	NM_015566	NP_056381	Q9Y6X4	F169A_HUMAN	hypothetical protein LOC26049	276											0						TCCAGACATAGGTCTTTTAGG	0.368			NA											10	140					2.27111e-07	3.83468e-07	0.001368	1	0
MEGF10	84466	broad.mit.edu	37	5	126754829	126754829	+	Silent	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:126754829C>G	uc003kuh.3	+	12	1685	c.1323C>G	c.(1321-1323)ACC>ACG	p.T441T	MEGF10_uc010jdc.1_Silent_p.T441T|MEGF10_uc010jdd.1_Silent_p.T441T|MEGF10_uc003kui.3_Silent_p.T441T	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	441	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACTGCTCTACCCCATGCCCTC	0.448			NA											13	202					0	0	0.003163	0	0
MEGF10	84466	broad.mit.edu	37	5	126792950	126792950	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:126792950C>T	uc003kuh.3	+	26	3725	c.3363C>T	c.(3361-3363)TCC>TCT	p.S1121S	MEGF10_uc003kui.3_Silent_p.S1121S	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	1121	Cytoplasmic (Potential).|Necessary for formation of large intracellular vacuoles.|Ser-rich.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACAGTTCATCCTCCCCTAAGC	0.453			NA											6	30					0	0	0.00308	0	0
SEC24A	10802	broad.mit.edu	37	5	134002584	134002584	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:134002584C>T	uc003kzs.2	+	3	925	c.637C>T	c.(637-639)CCT>TCT	p.P213S	SEC24A_uc011cxu.1_5'UTR	NM_021982	NP_068817	O95486	SC24A_HUMAN	SEC24 related gene family, member A	213	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TCATGGGCCCCCTCCAGCTGG	0.522			NA											9	83					0	0	0.000978	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175994	140175994	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:140175994C>T	uc003lhd.2	+	1	1551	c.1445C>T	c.(1444-1446)GCG>GTG	p.A482V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Missense_Mutation_p.A482V|PCDHA2_uc011czy.1_Missense_Mutation_p.A482V	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	482	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGTGGGATGCGGACGCGCAG	0.657			NA											3	54					0	0	0.004672	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181956	140181956	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:140181956C>A	uc003lhf.2	+	1	1174	c.1174C>A	c.(1174-1176)CAC>AAC	p.H392N	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.H392N	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	392	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGACGCCCCACGTCCCCTT	0.567			NA											5	102					3.59834e-05	5.19628e-05	0.001168	1	0
PCDHA11	56138	broad.mit.edu	37	5	140249814	140249814	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:140249814C>A	uc003lia.2	+	1	1984	c.1126C>A	c.(1126-1128)CGT>AGT	p.R376S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Missense_Mutation_p.R376S	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	376	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGTCTGACCGTGACTCAGG	0.572			NA											12	94					7.93312e-07	1.29949e-06	0.00245	1	0
RANBP17	64901	broad.mit.edu	37	5	170640697	170640697	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:170640697G>T	uc003mba.2	+	21	2310	c.2294G>T	c.(2293-2295)TGT>TTT	p.C765F	RANBP17_uc003mbb.2_Missense_Mutation_p.C90F|RANBP17_uc003mbd.2_Missense_Mutation_p.C128F|RANBP17_uc010jjs.2_RNA	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	765					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GAGCCAACATGTACAACTCCC	0.418			NA	T	TRD@	ALL								26	232					2.65835e-16	5.63775e-16	0.007291	1	0
CDHR2	54825	broad.mit.edu	37	5	176011514	176011514	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:176011514C>A	uc003mem.1	+	19	2298	c.2232C>A	c.(2230-2232)ATC>ATA	p.I744I	CDHR2_uc003men.1_Silent_p.I744I	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	744	Cadherin 7.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						ACTTCATGATCCGAGGCTTGG	0.632			NA											10	138					0.00185496	0.00226202	0.001855	1	0
OR2Y1	134083	broad.mit.edu	37	5	180166174	180166174	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:180166174G>A	uc003mmf.1	-	1	885	c.885C>T	c.(883-885)GAC>GAT	p.D295D		NM_001001657	NP_001001657	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCCTTCACGTCCTTGTTTC	0.408			NA											8	231					0	0	0.008291	0	0
MGAT1	4245	broad.mit.edu	37	5	180218718	180218718	+	Silent	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:180218718A>C	uc003mmg.3	-	2	1749	c.1254T>G	c.(1252-1254)GGT>GGG	p.G418G	MGAT1_uc010jlf.2_Silent_p.G418G|MGAT1_uc010jlg.2_Silent_p.G418G|MGAT1_uc003mmh.3_Silent_p.G418G|MGAT1_uc010jlh.2_Silent_p.G418G|MGAT1_uc003mmi.3_Silent_p.G418G	NM_002406	NP_002397	P26572	MGAT1_HUMAN	mannosyl (alpha-1,3-)-glycoprotein	418	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(1)	1	all_cancers(89;1.11e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.0027)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00356)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGTGACAATACCCCGGTAGC	0.612			NA											7	26					0	0	0.000978	0	0
KLHL31	401265	broad.mit.edu	37	6	53519984	53519984	+	Silent	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:53519984T>C	uc003pcb.3	-	2	228	c.87A>G	c.(85-87)AAA>AAG	p.K29K		NM_001003760	NP_001003760	Q9H511	KLH31_HUMAN	kelch repeat and BTB (POZ) domain containing 1	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent					ovary(1)	1	Lung NSC(77;0.0158)					AAGCATTCAGTTTGTTTAGGG	0.423			NA											6	88					0	0	0.001168	0	0
GJA10	84694	broad.mit.edu	37	6	90604267	90604267	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:90604267C>A	uc011eaa.1	+	1	80	c.80C>A	c.(79-81)ACC>AAC	p.T27N		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	27	Helical; (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		ATCTGGCTGACCATCCTCTTC	0.507			NA											19	156					1.33834e-09	2.47903e-09	0.007413	1	0
EPHA7	2045	broad.mit.edu	37	6	94120814	94120814	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:94120814G>T	uc003poe.2	-	3	478	c.237C>A	c.(235-237)CCC>CCA	p.P79P	EPHA7_uc003pof.2_Silent_p.P79P|EPHA7_uc011eac.1_Silent_p.P79P|EPHA7_uc003pog.3_Silent_p.P79P	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	79	Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		TGTTTTGGTTGGGCTCCATGA	0.418			NA											13	179					1.36491e-13	2.77405e-13	0.001855	1	0
BCLAF1	9774	broad.mit.edu	37	6	136597201	136597201	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:136597201T>A	uc003qgx.1	-	5	1715	c.1462A>T	c.(1462-1464)ATA>TTA	p.I488L	BCLAF1_uc003qgw.1_Intron|BCLAF1_uc003qgy.1_Missense_Mutation_p.I486L|BCLAF1_uc011edc.1_Intron|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Missense_Mutation_p.I486L	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	488					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTTACTGTTATTCTTTCAGAA	0.363	Colon(142;1534 1789 5427 7063 28491)		NA											17	355					0	0	0.007413	0	0
CCDC28A	25901	broad.mit.edu	37	6	139097279	139097279	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:139097279A>G	uc003qie.2	+	2	447	c.292A>G	c.(292-294)AGG>GGG	p.R98G	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	98											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		GAAAGTGAAGAGGAGGAGTCC	0.403			NA											22	101					0	0	0.002299	0	0
SYNE1	23345	broad.mit.edu	37	6	152725441	152725441	+	Silent	SNP	A	A	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:152725441A>C	uc010kiw.2	-	46	7334	c.6732T>G	c.(6730-6732)GTT>GTG	p.V2244V	SYNE1_uc003qot.3_Silent_p.V2251V|SYNE1_uc003qou.3_Silent_p.V2244V|SYNE1_uc010kjb.1_Silent_p.V2227V	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2244	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTTGTTTTTAACTTCAGACT	0.333			NA								HNSCC(10;0.0054)			9	139					0	0	0.006214	0	0
RBM16	22828	broad.mit.edu	37	6	155152133	155152133	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:155152133G>T	uc003qqa.2	+	20	2450	c.2218G>T	c.(2218-2220)GGT>TGT	p.G740C	TIAM2_uc003qqb.2_5'Flank|RBM16_uc011efj.1_Missense_Mutation_p.G806C|RBM16_uc011efk.1_Missense_Mutation_p.G785C|RBM16_uc003qpz.2_Missense_Mutation_p.G740C|RBM16_uc010kji.2_Missense_Mutation_p.G761C	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	740	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		TATACCAGGCGGTTCTGTTGC	0.433			NA											16	131					1.00905e-13	2.06033e-13	0.008871	1	0
MAP3K4	4216	broad.mit.edu	37	6	161508882	161508882	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:161508882G>T	uc003qtn.2	+	10	2861	c.2719G>T	c.(2719-2721)GGT>TGT	p.G907C	MAP3K4_uc010kkc.1_Missense_Mutation_p.G907C|MAP3K4_uc003qto.2_Missense_Mutation_p.G907C|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Missense_Mutation_p.G360C	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	907					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		GACCAAGCACGGTGATCGAGC	0.512			NA											23	112					2.21704e-12	4.44419e-12	0.00278	1	0
PDE10A	10846	broad.mit.edu	37	6	165792703	165792703	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:165792703G>T	uc003qun.2	-	19	2176	c.1935C>A	c.(1933-1935)AAC>AAA	p.N645K	PDE10A_uc011egj.1_RNA|PDE10A_uc011egk.1_Missense_Mutation_p.N575K|PDE10A_uc003quo.2_Missense_Mutation_p.N655K	NM_006661	NP_006652	Q9Y233	PDE10_HUMAN	phosphodiesterase 10A isoform 2	645					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			ovary(3)|skin(2)	5		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GATTATTAAGGTTTAGTGATC	0.368	Esophageal Squamous(22;308 615 5753 12038 40624)		NA											14	165					4.3838e-07	7.28973e-07	0.001855	1	0
TMEM195	392636	broad.mit.edu	37	7	15430503	15430503	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:15430503T>A	uc003stb.1	-	7	874	c.704A>T	c.(703-705)AAT>ATT	p.N235I		NM_001004320	NP_001004320	Q6ZNB7	ALKMO_HUMAN	transmembrane protein 195	235					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding				0						ACCAGCATAATTTTTGTCTAT	0.259			NA											10	38					0	0	0.000978	0	0
FERD3L	222894	broad.mit.edu	37	7	19184745	19184745	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:19184745C>A	uc003suo.1	-	1	300	c.241G>T	c.(241-243)GAG>TAG	p.E81*	uc003sun.1_RNA	NM_152898	NP_690862	Q96RJ6	FER3L_HUMAN	nephew of atonal 3	81	Poly-Glu.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			large_intestine(1)	1						cttccgcgctcctcttcctcc	0.358			NA											7	30					8.12818e-05	0.000111161	0.001984	1	0
CLK2P	1197	broad.mit.edu	37	7	23625238	23625238	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:23625238C>G	uc003swk.2	-	1	909	c.259G>C	c.(259-261)GAG>CAG	p.E87Q		NR_002711				SubName: Full=cDNA FLJ61616, highly similar to Dual specificity protein kinase CLK2 (EC 2.7.12.1); SubName: Full=CDC-like kinase 2, isoform CRA_c; SubName: Full=Putative uncharacterized protein CLK2;												0						ACACTGCGCTCATGTCGCTTC	0.493			NA											8	136					0	0	0.00308	0	0
HOXA2	3199	broad.mit.edu	37	7	27141063	27141063	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:27141063C>A	uc003syh.2	-	2	688	c.413G>T	c.(412-414)GGC>GTC	p.G138V		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	138						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						CCCGCCGCTGCCATCGGCGAT	0.542			NA											3	28					0.000602214	0.000753197	0.000602	1	0
POU6F2	11281	broad.mit.edu	37	7	39247049	39247049	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:39247049C>A	uc003thb.1	+	4	383	c.341C>A	c.(340-342)CCC>CAC	p.P114H	POU6F2_uc010kxo.2_Missense_Mutation_p.P106H	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	114					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						CCGGGAGGCCCCCCAGCCCTC	0.582			NA											10	94					6.31663e-08	1.1092e-07	0.003163	1	0
HECW1	23072	broad.mit.edu	37	7	43531769	43531769	+	Silent	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:43531769A>G	uc003tid.1	+	18	3935	c.3330A>G	c.(3328-3330)TCA>TCG	p.S1110S	HECW1_uc011kbi.1_Silent_p.S1076S	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	1110					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						AACATGAGTCATTGCCACTGG	0.433			NA											9	69					0	0	0.008291	0	0
RAMP3	10268	broad.mit.edu	37	7	45222926	45222926	+	Missense_Mutation	SNP	C	C	T	rs146295145		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:45222926C>T	uc003tnb.2	+	3	423	c.362C>T	c.(361-363)CCG>CTG	p.P121L	RAMP3_uc003tnc.2_Missense_Mutation_p.P89L	NM_005856	NP_005847	O60896	RAMP3_HUMAN	receptor activity modifying protein 3 precursor	121	Helical; (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	integral to plasma membrane|lysosome	protein transporter activity				0					Pramlintide(DB01278)	GTTCTCATCCCGCTGATCGTT	0.622			NA											11	193					0	0	0.000978	0	0
ZNF479	90827	broad.mit.edu	37	7	57188064	57188064	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:57188064T>C	uc010kzo.2	-	5	1329	c.1058A>G	c.(1057-1059)TAT>TGT	p.Y353C		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	353	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TTCACAGGCATAGGGTTTCTC	0.438			NA											12	72					0	0	0.001855	0	0
ABCB1	5243	broad.mit.edu	37	7	87179543	87179543	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:87179543C>T	uc003uiz.1	-	13	1712	c.1294G>A	c.(1294-1296)GGG>AGG	p.G432R	ABCB1_uc011khc.1_Missense_Mutation_p.G368R	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	432	ATP 1 (By similarity).|ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GTGCTCTTCCCACAGCCACTG	0.552			NA											4	36					0	0	0.001984	0	0
SAMD9	54809	broad.mit.edu	37	7	92731291	92731291	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:92731291C>A	uc003umf.2	-	3	4376	c.4120G>T	c.(4120-4122)GAA>TAA	p.E1374*	SAMD9_uc003umg.2_Nonsense_Mutation_p.E1374*	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1374						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			GTGCATTGTTCTAAGAGAAAA	0.363			NA											18	191					2.94398e-08	5.27514e-08	0.007413	1	0
DYNC1I1	1780	broad.mit.edu	37	7	95616384	95616384	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:95616384G>T	uc003uoc.3	+	9	1088	c.811G>T	c.(811-813)GCC>TCC	p.A271S	DYNC1I1_uc003uod.3_Missense_Mutation_p.A254S|DYNC1I1_uc003uob.2_Missense_Mutation_p.A234S|DYNC1I1_uc003uoe.3_Missense_Mutation_p.A251S|DYNC1I1_uc010lfl.2_Missense_Mutation_p.A260S	NM_004411	NP_004402	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	271					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			ovary(3)|kidney(1)	4	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TCAGGCTGGAGCCAATCTTTC	0.433			NA											25	560					1.77063e-15	3.73705e-15	0.005443	1	0
LMTK2	22853	broad.mit.edu	37	7	97822649	97822649	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:97822649G>T	uc003upd.1	+	11	3165	c.2872G>T	c.(2872-2874)GCA>TCA	p.A958S		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	958					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.A958T(1)		lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					TTCTAAAGACGCAGCAAAAGA	0.502			NA											7	95					7.48243e-07	1.23488e-06	0.006214	1	0
MUC17	140453	broad.mit.edu	37	7	100677756	100677757	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:100677756_100677757CC>AA	uc003uxp.1	+	3	3112_3113	c.3059_3060CC>AA	c.(3058-3060)GCC>GAA	p.A1020E	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1020	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|15.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCTACTGAAGCCAGTTCACCTC	0.525			NA											26	660					0	0	0.004672	0	0
SH2B2	10603	broad.mit.edu	37	7	101952177	101952177	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:101952177C>T	uc011kko.1	+	4	1086	c.1041C>T	c.(1039-1041)TGC>TGT	p.C347C		NM_020979	NP_066189	O14492	SH2B2_HUMAN	SH2B adaptor protein 2	304	PH.				blood coagulation|insulin receptor signaling pathway|intracellular signal transduction	cytosol|plasma membrane	JAK pathway signal transduction adaptor activity|SH3/SH2 adaptor activity|signal transducer activity				0						TCCAGGGCTGCGTGGACCCCG	0.607			NA											11	145					0	0	0.008291	0	0
RELN	5649	broad.mit.edu	37	7	103214661	103214661	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:103214661G>T	uc003vca.2	-	30	4549	c.4389C>A	c.(4387-4389)TAC>TAA	p.Y1463*	RELN_uc010liz.2_Nonsense_Mutation_p.Y1463*	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	1463					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CTGTTATCTTGTACCACAGAG	0.498	NSCLC(146;835 1944 15585 22231 52158)		NA											5	143					2.0095e-06	3.24327e-06	0.001984	1	0
PAX4	5078	broad.mit.edu	37	7	127255560	127255560	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:127255560C>T	uc010lld.1	-	1	221	c.15G>A	c.(13-15)GGG>GGA	p.G5G	PAX4_uc003vmf.2_5'UTR|PAX4_uc003vmg.1_Silent_p.G5G|PAX4_uc003vmh.2_5'UTR	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	13	Paired.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAAAGAGCCCCCCAAGCTGGT	0.627	Ovarian(113;737 1605 7858 27720 34092)		NA											4	77					0	0	0.000602	0	0
LEP	3952	broad.mit.edu	37	7	127892140	127892140	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:127892140C>T	uc003vml.2	+	2	126	c.69C>T	c.(67-69)CCC>CCT	p.P23P	LEP_uc003vmm.2_Silent_p.P23P	NM_000230	NP_000221	P41159	LEP_HUMAN	leptin precursor	23					adult feeding behavior|energy reserve metabolic process|negative regulation of appetite|placenta development|positive regulation of developmental growth	extracellular space					0						AAGCTGTGCCCATCCAAAAAG	0.488			NA											19	222					0	0	0.008871	0	0
FLNC	2318	broad.mit.edu	37	7	128493588	128493588	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:128493588G>T	uc003vnz.3	+	38	6483	c.6274G>T	c.(6274-6276)GAG>TAG	p.E2092*	FLNC_uc003voa.3_Nonsense_Mutation_p.E2059*	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2092	Filamin 19.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TGAGGACATGGAGGACGGGAC	0.562			NA											4	41					1.23904e-05	1.87565e-05	0.000602	1	0
MGAM	8972	broad.mit.edu	37	7	141758016	141758016	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:141758016C>T	uc003vwy.2	+	31	3761	c.3707C>T	c.(3706-3708)CCT>CTT	p.P1236L		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1236	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ATTGGCCGGCCTGTGATGGTA	0.438			NA											31	467					0	0	0.006999	0	0
TRYX3	136541	broad.mit.edu	37	7	141955355	141955355	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:141955355G>C	uc003vxb.2	-	2	499	c.179C>G	c.(178-180)CCA>CGA	p.P60R	TRYX3_uc003vxc.3_Missense_Mutation_p.P60R	NM_001001317	NP_001001317	Q8IYP2	PRS58_HUMAN	trypsin X3 precursor	60	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity				0	Melanoma(164;0.0272)					TATCACTCACGGTAAATTGCA	0.498			NA											9	112					0	0	0.008291	0	0
PRSS1	5644	broad.mit.edu	37	7	142459655	142459655	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:142459655C>A	uc003wak.2	+	3	248	c.231C>A	c.(229-231)AAC>AAA	p.N77K	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.N17K	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	77	Peptidase S1.	Calcium; via carbonyl oxygen.			digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GAGAGCACAACATCGAAGTCC	0.552			NA							Hereditary_Pancreatitis				10	204					2.27111e-07	3.83468e-07	0.001368	1	0
TRPV6	55503	broad.mit.edu	37	7	142574936	142574936	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:142574936C>A	uc003wbx.1	-	4	662	c.446G>T	c.(445-447)GGC>GTC	p.G149V	TRPV6_uc003wbw.1_5'Flank|TRPV6_uc010lou.1_Missense_Mutation_p.G20V	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	149	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					GAAGGCAGTGCCTGTGGCTCT	0.433			NA											3	25					0.000602214	0.000753197	0.000602	1	0
GIMAP2	26157	broad.mit.edu	37	7	150390208	150390208	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:150390208G>C	uc003who.2	+	3	922	c.834G>C	c.(832-834)CAG>CAC	p.Q278H	GIMAP1_uc003whp.2_Intron	NM_015660	NP_056475	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	278	Helical; (Potential).					integral to membrane	GTP binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTTGTATTCAGTTGTTTCTCA	0.363			NA											3	64					0	0	0.000248	0	0
CSMD1	64478	broad.mit.edu	37	8	2855612	2855612	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:2855612C>A	uc011kwk.1	-	54	8691	c.8301G>T	c.(8299-8301)ACG>ACT	p.T2767T	CSMD1_uc011kwj.1_Silent_p.T2096T|CSMD1_uc010lrg.2_Silent_p.T777T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2767	Extracellular (Potential).|Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCAAATAGCCCGTGTTGCAGG	0.557			NA											5	70					0.000602214	0.000753197	0.000602	1	0
TNKS	8658	broad.mit.edu	37	8	9623218	9623218	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:9623218A>T	uc003wss.2	+	24	3469	c.3464A>T	c.(3463-3465)AAC>ATC	p.N1155I	TNKS_uc011kww.1_Missense_Mutation_p.N918I	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1155	PARP catalytic.				mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		AAAGTTGTCAACAAGAAGTTG	0.388			NA											6	94					0	0	0.004482	0	0
SOX7	83595	broad.mit.edu	37	8	10583456	10583456	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:10583456T>A	uc003wtf.2	-	2	1038	c.959A>T	c.(958-960)CAG>CTG	p.Q320L	SOX7_uc011kwz.1_Missense_Mutation_p.Q372L	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	320	Sox C-terminal.				endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GAGTTCCACCTGGCTCAGTTG	0.627			NA											6	40					0	0	0.001984	0	0
EBF2	64641	broad.mit.edu	37	8	25716008	25716008	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:25716008T>C	uc003xes.1	-	14	1372	c.1355A>G	c.(1354-1356)AAC>AGC	p.N452S	PPP2R2A_uc003xek.2_Intron|EBF2_uc010lug.1_RNA	NM_022659	NP_073150	Q9HAK2	COE2_HUMAN	early B-cell factor 2	452					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding			ovary(3)|skin(1)	4		all_cancers(63;0.0989)|Ovarian(32;2.74e-05)|all_epithelial(46;0.0608)|Prostate(55;0.0845)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0277)|Epithelial(17;3.29e-10)|Colorectal(74;0.00383)|COAD - Colon adenocarcinoma(73;0.00738)		GCTGCTTGTGTTGCGGATGTA	0.522	Esophageal Squamous(166;1018 1046 3854 8328 13429 13634 14071 26624 32918)		NA											7	55					0	0	0.00308	0	0
EXTL3	2137	broad.mit.edu	37	8	28573840	28573840	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:28573840G>T	uc003xgz.1	+	3	857	c.264G>T	c.(262-264)TCG>TCT	p.S88S		NM_001440	NP_001431	O43909	EXTL3_HUMAN	exostoses-like 3	88	Lumenal (Potential).					integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			skin(2)	2		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		TCCGGGAGTCGGTGAGTGAAG	0.582			NA											5	38					1.23904e-05	1.87565e-05	0.000602	1	0
BRF2	55290	broad.mit.edu	37	8	37704488	37704488	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:37704488C>A	uc003xkk.2	-	3	530	c.420G>T	c.(418-420)ACG>ACT	p.T140T		NM_018310	NP_060780	Q9HAW0	BRF2_HUMAN	RNA polymerase III transcription initiation	140	1.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding				0		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			CATACAACAGCGTGCAGATGG	0.527			NA											17	350					5.01169e-05	7.14329e-05	0.00499	1	0
MYBL1	4603	broad.mit.edu	37	8	67492485	67492485	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:67492485C>T	uc003xwj.2	-	9	1391	c.984G>A	c.(982-984)CAG>CAA	p.Q328Q	MYBL1_uc003xwl.2_Silent_p.Q328Q|MYBL1_uc003xwk.2_Silent_p.Q327Q	NM_001080416	NP_001073885	P10243	MYBA_HUMAN	v-myb myeloblastosis viral oncogene homolog	328	Negative regulatory domain (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)	3			Epithelial(68;0.00211)|all cancers(69;0.00726)|OV - Ovarian serous cystadenocarcinoma(28;0.00989)|BRCA - Breast invasive adenocarcinoma(89;0.0938)			CAGACACAGGCTGATTTTCAT	0.458			NA											9	44					0	0	0.006214	0	0
SNX31	169166	broad.mit.edu	37	8	101601166	101601166	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:101601166G>T	uc003yjr.2	-	11	1171	c.1020C>A	c.(1018-1020)AAC>AAA	p.N340K	SNX31_uc011lha.1_Missense_Mutation_p.N135K|SNX31_uc011lhb.1_Missense_Mutation_p.N241K	NM_152628	NP_689841	Q8N9S9	SNX31_HUMAN	sorting nexin 31	340					cell communication|protein transport		phosphatidylinositol binding				0	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CTAAGTTCTGGTTGAGAGTTC	0.358			NA											7	84					8.12818e-05	0.000111161	0.001984	1	0
TRPS1	7227	broad.mit.edu	37	8	116617157	116617157	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:116617157G>C	uc003ynz.2	-	3	1459	c.1000C>G	c.(1000-1002)CGC>GGC	p.R334G	TRPS1_uc011lhy.1_Missense_Mutation_p.R338G|TRPS1_uc003yny.2_Missense_Mutation_p.R347G|TRPS1_uc010mcy.2_Missense_Mutation_p.R334G	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	334	C2H2-type 2; atypical.				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AATTTACAGCGGAAATACTTG	0.413			NA							Langer-Giedion_syndrome				8	161					0	0	0.004482	0	0
ZHX1	11244	broad.mit.edu	37	8	124266616	124266616	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:124266616C>A	uc003yqe.2	-	3	2001	c.1571G>T	c.(1570-1572)AGT>ATT	p.S524I	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.S524I|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.S524I	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	524	Homeobox 2.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GCACTGATTACTCTTTGAATT	0.388			NA											28	337					6.12954e-19	1.31262e-18	0.004656	1	0
TMED10P1	286102	broad.mit.edu	37	8	146220548	146220548	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr8:146220548G>A	uc003zey.2	+	1	298	c.277G>A	c.(277-279)GGG>AGG	p.G93R	ZNF252_uc003zew.3_Intron|ZNF252_uc011llo.1_Intron	NR_002807				Homo sapiens mRNA for Tmp21-II putative transcribed pseudogene.												0						TACAACCAAGGGGAAATTTGC	0.458			NA											5	88					0	0	0.000602	0	0
DENND4C	55667	broad.mit.edu	37	9	19369931	19369931	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:19369931T>G	uc003znq.2	+	26	4799	c.4766T>G	c.(4765-4767)CTT>CGT	p.L1589R	DENND4C_uc011lnc.1_Missense_Mutation_p.L919R|DENND4C_uc011lnd.1_Missense_Mutation_p.L877R|DENND4C_uc003znr.2_Missense_Mutation_p.L877R|DENND4C_uc003zns.2_Missense_Mutation_p.L771R	NM_017925	NP_060395	Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	1589						integral to membrane				ovary(1)|skin(1)	2						AATAATGTTCTTAAACCCATC	0.378			NA											4	93					0	0	0.000248	0	0
TOPORS	10210	broad.mit.edu	37	9	32543811	32543811	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:32543811T>A	uc003zrb.2	-	3	879	c.712A>T	c.(712-714)AGG>TGG	p.R238W	TOPORS_uc003zrc.2_Missense_Mutation_p.R171W	NM_005802	NP_005793	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich	238	Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		GTAGTTGGCCTCCTTACTGCA	0.398			NA											7	218					0	0	0.00308	0	0
UNC13B	10497	broad.mit.edu	37	9	35403960	35403960	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:35403960G>T	uc003zwq.2	+	39	4998	c.4706G>T	c.(4705-4707)AGC>ATC	p.S1569I	UNC13B_uc003zwr.2_Missense_Mutation_p.S1588I|ATP8B5P_uc010mkn.1_5'Flank|ATP8B5P_uc010mko.2_5'Flank|ATP8B5P_uc010mkp.2_5'Flank|ATP8B5P_uc003zwu.2_5'Flank	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1569					excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			TCTCAGAGGAGCAATGACGAG	0.557			NA											5	79					1.024e-07	1.78387e-07	0.000602	1	0
Unknown	0	broad.mit.edu	37	9	84676025	84676026	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:84676025_84676026GG>TT	uc010mpu.1	-	3	402_403	c.399_400CC>AA	c.(397-402)TCCCAG>TCAAAG	p.Q134K		NM_001164339	NP_001157811			hypothetical protein LOC404770												NA						TCTGGTGGCTGGGAGGCACTTA	0.589			NA											16	273					0	0	0.004672	0	0
FAM75C1	441452	broad.mit.edu	37	9	90536768	90536768	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:90536768A>T	uc010mqi.2	+	4	1975	c.1946A>T	c.(1945-1947)CAG>CTG	p.Q649L	FAM75C1_uc004apq.3_Missense_Mutation_p.Q632L	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						CTGTGTACTCAGCAGGTGCTG	0.522			NA											22	201					0	0	0.001882	0	0
Unknown	0	broad.mit.edu	37	9	90744734	90744734	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:90744734C>T	uc011lti.1	-	4	3247	c.3218G>A	c.(3217-3219)CGC>CAC	p.R1073H	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;												NA						CGAGGCATGGCGCGCATGGCA	0.517			NA											4	104					0	0	0.000248	0	0
ROR2	4920	broad.mit.edu	37	9	94486066	94486066	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:94486066C>A	uc004arj.1	-	9	2909	c.2710G>T	c.(2710-2712)GGG>TGG	p.G904W	ROR2_uc004ari.1_Intron	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	904	Cytoplasmic (Potential).				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						CTCTGGGCCCCATCTTCTGGG	0.637			NA											11	135					4.3838e-07	7.28973e-07	0.001855	1	0
OGN	4969	broad.mit.edu	37	9	95163438	95163438	+	Silent	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:95163438C>T	uc004asa.2	-	3	439	c.204G>A	c.(202-204)GAG>GAA	p.E68E	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|OGN_uc004asb.2_Silent_p.E68E|OGN_uc011ltx.1_Silent_p.E86E	NM_014057	NP_054776	P20774	MIME_HUMAN	osteoglycin preproprotein	68						extracellular space|proteinaceous extracellular matrix	growth factor activity				0						GAAGACTTTTCTCATTGGGTA	0.214			NA											9	188					0	0	0.006214	0	0
ECM2	1842	broad.mit.edu	37	9	95272247	95272247	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:95272247A>G	uc004ash.2	-	6	1305	c.1240T>C	c.(1240-1242)TCT>CCT	p.S414P	CENPP_uc004arz.2_Intron|CENPP_uc010mqx.2_Intron|ECM2_uc004asf.3_Missense_Mutation_p.S392P|ECM2_uc011lty.1_Missense_Mutation_p.S414P|ECM2_uc004asg.2_Missense_Mutation_p.S392P	NM_001393	NP_001384	O94769	ECM2_HUMAN	extracellular matrix protein 2 precursor	414	LRR 2.				cell-matrix adhesion		integrin binding			ovary(1)|skin(1)	2						TCTAATGTAGATGGCAATTGT	0.299			NA											3	83					0	0	0.004672	0	0
C9orf102	375748	broad.mit.edu	37	9	98678023	98678023	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:98678023A>T	uc004avt.3	+	5	1283	c.895A>T	c.(895-897)ATG>TTG	p.M299L	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_Missense_Mutation_p.M1L|C9orf102_uc010mry.1_Missense_Mutation_p.M1L|C9orf102_uc010mrz.2_Missense_Mutation_p.M110L	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	299	Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				AACAGAAGTTATGAAAGCTTT	0.398			NA											15	131					0	0	0.003163	0	0
COL15A1	1306	broad.mit.edu	37	9	101797630	101797630	+	Splice_Site	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:101797630A>T	uc004azb.1	+	19	2427	c.2221_splice	c.e19-2	p.D741_splice		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor						angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				CTCCTTCCCCAGGATACCGAA	0.318			NA											11	114					0	0	0.00245	0	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112898635	112898635	+	Missense_Mutation	SNP	G	G	T	rs146199973	byFrequency	TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:112898635G>T	uc004bei.2	+	9	1699	c.1507G>T	c.(1507-1509)GAT>TAT	p.D503Y	PALM2-AKAP2_uc004bek.3_Missense_Mutation_p.D271Y|PALM2-AKAP2_uc004bej.3_Missense_Mutation_p.D271Y|PALM2-AKAP2_uc004bel.1_Missense_Mutation_p.D81Y|AKAP2_uc011lwi.1_Missense_Mutation_p.D129Y|AKAP2_uc004bem.2_Missense_Mutation_p.D129Y|PALM2-AKAP2_uc010mtw.1_Missense_Mutation_p.D89Y|AKAP2_uc011lwj.1_Missense_Mutation_p.D40Y|PALM2-AKAP2_uc004ben.2_Missense_Mutation_p.D40Y	NM_001136562	NP_001130034	Q9Y2D5	AKAP2_HUMAN	A kinase (PRKA) anchor protein 2 isoform 2	40							enzyme binding			ovary(3)|central_nervous_system(2)|skin(1)	6						CCTCCTTACTGATCACCACGA	0.498			NA											9	227					0.000442599	0.000564829	0.006214	1	0
TLR4	7099	broad.mit.edu	37	9	120475650	120475650	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr9:120475650G>T	uc004bjz.2	+	3	1535	c.1244G>T	c.(1243-1245)AGT>ATT	p.S415I	TLR4_uc004bka.2_Missense_Mutation_p.S375I|TLR4_uc004bkb.2_Missense_Mutation_p.S215I	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	415	LRR 12.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ATTACCATGAGTTCAAACTTC	0.373			NA											13	164					7.93312e-07	1.29949e-06	0.00245	1	0
MXRA5	25878	broad.mit.edu	37	X	3240239	3240239	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:3240239G>A	uc004crg.3	-	5	3644	c.3487C>T	c.(3487-3489)CGC>TGC	p.R1163C		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1163						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGCCGGTGGCGGAATTTGTTG	0.493			NA											16	199					0	0	0.006122	0	0
PHKA2	5256	broad.mit.edu	37	X	18972504	18972504	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:18972504G>T	uc004cyv.3	-	2	535	c.105C>A	c.(103-105)GCC>GCA	p.A35A	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_5'UTR	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	35					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					GCTCATGGCTGGCTGACAGCA	0.552			NA											7	84					7.48243e-07	1.23488e-06	0.006214	1	0
PTCHD1	139411	broad.mit.edu	37	X	23412216	23412216	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:23412216A>T	uc004dal.3	+	3	2589	c.2581A>T	c.(2581-2583)AAT>TAT	p.N861Y		NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	861					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						AGAGAAGAAAAATCCTGAGAA	0.398			NA											10	187					0	0	0.006214	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938086	29938086	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:29938086G>T	uc004dby.2	+	8	1440	c.932G>T	c.(931-933)GGG>GTG	p.G311V		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	311	Extracellular (Potential).|Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						GAGCATCTTGGGGAACAGGAA	0.373			NA											11	252					1.61879e-10	3.11688e-10	0.001368	1	0
DMD	1756	broad.mit.edu	37	X	32382758	32382758	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:32382758C>T	uc004dda.1	-	36	5339	c.5095G>A	c.(5095-5097)GAC>AAC	p.D1699N	DMD_uc004dcw.2_Missense_Mutation_p.D355N|DMD_uc004dcx.2_Missense_Mutation_p.D358N|DMD_uc004dcz.2_Missense_Mutation_p.D1576N|DMD_uc004dcy.1_Missense_Mutation_p.D1695N|DMD_uc004ddb.1_Missense_Mutation_p.D1691N|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	1699	Spectrin 12.|Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				AAAAGTGTGTCAGCCTGAATG	0.373			NA											12	249					0	0	0.000978	0	0
FAM47C	442444	broad.mit.edu	37	X	37028015	37028015	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:37028015G>A	uc004ddl.1	+	1	1546	c.1532G>A	c.(1531-1533)CGC>CAC	p.R511H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	511										ovary(3)	3						TCTCATCTCCGCCCAGAGCCT	0.602			NA											9	131					0	0	0.004482	0	0
RPGR	6103	broad.mit.edu	37	X	38132700	38132700	+	Nonsense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:38132700G>C	uc004deb.2	-	18	2348	c.2180C>G	c.(2179-2181)TCA>TGA	p.S727*	RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_000328	NP_000319	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform A	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GATTTCTAATGAACTGCTATC	0.328			NA											4	58					0	0	0.000248	0	0
RPGR	6103	broad.mit.edu	37	X	38169932	38169932	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:38169932C>A	uc004ded.1	-	7	882	c.714G>T	c.(712-714)GTG>GTT	p.V238V	RPGR_uc004deb.2_Silent_p.V238V|RPGR_uc004dea.2_RNA|RPGR_uc004dec.2_RNA	NM_001034853	NP_001030025	Q92834	RPGR_HUMAN	retinitis pigmentosa GTPase regulator isoform C	238	RCC1 4.				intracellular protein transport|response to stimulus|visual perception	Golgi apparatus|photoreceptor outer segment	guanyl-nucleotide exchange factor activity|protein binding			ovary(1)	1						GAATTTCAGACACCAGCTGGG	0.507			NA											8	71					0.00307968	0.00362461	0.00308	1	0
DUSP21	63904	broad.mit.edu	37	X	44703492	44703492	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:44703492C>G	uc004dgd.2	+	1	244	c.114C>G	c.(112-114)AAC>AAG	p.N38K		NM_022076	NP_071359	Q9H596	DUS21_HUMAN	dual specificity phosphatase 21	38	Tyrosine-protein phosphatase.					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)	2						TGGCCGCCAACGACAAACTCC	0.512			NA											7	97					0	0	0.006214	0	0
CLCN5	1184	broad.mit.edu	37	X	49845313	49845313	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:49845313C>A	uc004dos.1	+	5	704	c.456C>A	c.(454-456)TTC>TTA	p.F152L	CLCN5_uc004dor.1_Missense_Mutation_p.F222L|CLCN5_uc004doq.1_Missense_Mutation_p.F222L|CLCN5_uc004dot.1_Missense_Mutation_p.F152L	NM_000084	NP_000075	P51795	CLCN5_HUMAN	chloride channel 5 isoform b	152	Helical; (By similarity).				excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			ovary(2)|lung(1)|central_nervous_system(1)	4	Ovarian(276;0.236)					TATTTGCCTTCCTTGCCGTAT	0.443			NA											5	150					1.23904e-05	1.87565e-05	0.000602	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912683	77912683	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:77912683G>T	uc004edc.1	-	2	1531	c.1235C>A	c.(1234-1236)CCC>CAC	p.P412H		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	412							nucleic acid binding|zinc ion binding			ovary(1)	1						TGGACTCTCGGGTCCATCTCC	0.527			NA											13	144					9.31168e-06	1.44958e-05	0.001855	1	0
LPAR4	2846	broad.mit.edu	37	X	78010954	78010954	+	Silent	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:78010954C>G	uc010nme.2	+	2	993	c.588C>G	c.(586-588)GTC>GTG	p.V196V		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	196	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						CCAAACGTGTCTGGAAGACTT	0.413			NA											8	160					0	0	0.004482	0	0
GPR174	84636	broad.mit.edu	37	X	78426662	78426662	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:78426662G>T	uc004edg.1	+	1	194	c.158G>T	c.(157-159)CGA>CTA	p.R53L		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	53	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						GAAACAAAACGAGCTGTGATA	0.373			NA								HNSCC(63;0.18)			4	40					2.56e-06	4.11663e-06	0.000248	1	0
CYLC1	1538	broad.mit.edu	37	X	83128563	83128563	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:83128563T>A	uc004eei.1	+	4	868	c.847T>A	c.(847-849)TAT>AAT	p.Y283N	CYLC1_uc004eeh.1_Missense_Mutation_p.Y282N	NM_021118	NP_066941	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head	283	1.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			ovary(4)|skin(1)	5						GTATACAAAGTATACAAAGAA	0.313			NA											7	69					0	0	0.001984	0	0
SATL1	340562	broad.mit.edu	37	X	84363147	84363147	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:84363147C>A	uc011mqx.1	-	1	828	c.828G>T	c.(826-828)ATG>ATT	p.M276I	SATL1_uc004een.2_Missense_Mutation_p.M276I	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	89	Gln-rich.						N-acetyltransferase activity			breast(2)	2						TCCATTGGTTCATGTCCATTT	0.448			NA											19	218					1.55795e-14	3.27243e-14	0.001882	1	0
GLA	2717	broad.mit.edu	37	X	100662735	100662735	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:100662735T>A	uc004ehl.1	-	1	267	c.157A>T	c.(157-159)AAC>TAC	p.N53Y	HNRNPH2_uc004ehm.2_5'Flank|HNRNPH2_uc004ehn.2_5'Flank|GLA_uc011mrj.1_Missense_Mutation_p.N53Y	NM_000169	NP_000160	P06280	AGAL_HUMAN	alpha-galactosidase A precursor	53					glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding				0					Agalsidase beta(DB00103)	CAGTCAAGGTTGCACATGAAG	0.552	Colon(193;776 2816 31189 44474)		NA											8	141					0	0	0.00308	0	0
NXF5	55998	broad.mit.edu	37	X	101096045	101096045	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:101096045C>A	uc011mrk.1	-	8	783	c.423G>T	c.(421-423)CTG>CTT	p.L141L	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_RNA|NXF5_uc004eil.1_RNA	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	141					mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						TTCTTCGATTCAGGATTATAT	0.522			NA											9	224					2.17888e-05	3.2646e-05	0.006214	1	0
NXF5	55998	broad.mit.edu	37	X	101096677	101096677	+	Missense_Mutation	SNP	C	C	T	rs145492861		TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:101096677C>T	uc011mrk.1	-	5	569	c.209G>A	c.(208-210)AGT>AAT	p.S70N	NXF5_uc004eih.1_RNA|NXF5_uc004eii.1_RNA|NXF5_uc004eij.1_RNA|NXF5_uc004eik.1_Intron|NXF5_uc004eil.1_Intron	NM_032946	NP_116564	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	70	RRM.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						AATCTTATAACTGACATCCTT	0.488			NA											6	203					0	0	0.00308	0	0
GPRASP1	9737	broad.mit.edu	37	X	101911404	101911404	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:101911404G>T	uc004ejj.3	+	5	3364	c.2563G>T	c.(2563-2565)GAG>TAG	p.E855*	GPRASP1_uc004eji.3_Nonsense_Mutation_p.E855*|GPRASP1_uc010nod.2_Nonsense_Mutation_p.E855*	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	855	Glu-rich.					cytoplasm	protein binding			ovary(1)|lung(1)	2						GGCCAGTCCGGAGGCAGTGGC	0.517			NA											8	143					0.000274275	0.000355182	0.004482	1	0
NXF3	56000	broad.mit.edu	37	X	102338133	102338133	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:102338133C>A	uc004eju.2	-	6	680	c.609G>T	c.(607-609)GTG>GTT	p.V203V	NXF3_uc010noi.1_Silent_p.V53V|NXF3_uc011mrw.1_Silent_p.V203V|NXF3_uc011mrx.1_Silent_p.V114V	NM_022052	NP_071335	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	203						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			ovary(1)|lung(1)|central_nervous_system(1)	3						TTATCTGCTCCACCTTTTCTG	0.498			NA											14	172					4.7546e-09	8.69696e-09	0.004007	1	0
TBC1D8B	54885	broad.mit.edu	37	X	106117037	106117037	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:106117037T>A	uc004emo.2	+	21	3370	c.3205T>A	c.(3205-3207)TTT>ATT	p.F1069I	MORC4_uc004emp.3_Intron	NM_017752	NP_060222	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	1069						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(2)|central_nervous_system(1)|skin(1)	4						TCCTTGTTCCTTTAGGGAGGA	0.458			NA											7	204					0	0	0.001984	0	0
TEX13B	56156	broad.mit.edu	37	X	107224961	107224961	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:107224961C>T	uc004enn.1	-	2	490	c.397G>A	c.(397-399)GAG>AAG	p.E133K		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	133										ovary(1)	1						AGGCTGGTCTCGGTTAGCTGC	0.572			NA											5	135					0	0	0.001168	0	0
ATG4A	115201	broad.mit.edu	37	X	107377577	107377577	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:107377577G>T	uc004enr.2	+	6	526	c.403G>T	c.(403-405)GGT>TGT	p.G135C	ATG4A_uc004ent.2_Missense_Mutation_p.G135C|ATG4A_uc004ens.2_Missense_Mutation_p.G51C|ATG4A_uc011msl.1_Missense_Mutation_p.G51C|ATG4A_uc010npi.2_Intron|ATG4A_uc004enu.2_Missense_Mutation_p.G51C	NM_052936	NP_443168	Q8WYN0	ATG4A_HUMAN	autophagy-related cysteine endopeptidase 2	135					autophagy|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity			pancreas(1)	1						AGCACAAATGGGTGTAGGAGA	0.338			NA											8	92					3.86212e-05	5.52271e-05	0.008291	1	0
ALG13	79868	broad.mit.edu	37	X	110925492	110925492	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:110925492C>T	uc011msy.1	+	2	248	c.214C>T	c.(214-216)CAG>TAG	p.Q72*	ALG13_uc004epi.1_Nonsense_Mutation_p.Q72*|ALG13_uc011msw.1_Intron|ALG13_uc011msx.1_5'UTR|ALG13_uc011msz.1_Intron|ALG13_uc011mta.1_5'UTR|ALG13_uc011mtb.1_5'UTR			Q9NP73	ALG13_HUMAN	SubName: Full=Asparagine-linked glycosylation 13 homolog (S. cerevisiae);	72					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			lung(1)	1						AGAAGACATTCAGAAAGCAGA	0.363			NA											9	238					0	0	0.006214	0	0
HTR2C	3358	broad.mit.edu	37	X	114141513	114141513	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:114141513C>A	uc004epu.1	+	6	1640	c.912C>A	c.(910-912)AAC>AAA	p.N304K	HTR2C_uc010nqc.1_Missense_Mutation_p.N304K|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	304	Cytoplasmic (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AGGCTATCAACAATGAAAGAA	0.458			NA											23	254					2.89027e-11	5.61428e-11	0.002299	1	0
HTR2C	3358	broad.mit.edu	37	X	114141543	114141543	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:114141543G>A	uc004epu.1	+	6	1670	c.942G>A	c.(940-942)GGG>GGA	p.G314G	HTR2C_uc010nqc.1_Silent_p.G314G|HTR2C_uc004epv.1_3'UTR	NM_000868	NP_000859	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C	314	Helical; Name=6; (By similarity).				cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			ovary(3)	3					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	AAGTCCTTGGGATTGTTTTCT	0.433			NA											24	290					0	0	0.00278	0	0
KLHL13	90293	broad.mit.edu	37	X	117079444	117079444	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:117079444G>T	uc004eql.2	-	2	255	c.193C>A	c.(193-195)CCT>ACT	p.P65T	KLHL13_uc004eqk.2_Missense_Mutation_p.P14T|KLHL13_uc011mtn.1_5'UTR|KLHL13_uc011mto.1_Missense_Mutation_p.P59T|KLHL13_uc011mtp.1_Missense_Mutation_p.P67T|KLHL13_uc004eqm.2_Missense_Mutation_p.P14T|KLHL13_uc011mtq.1_Missense_Mutation_p.P49T	NM_033495	NP_277030	Q9P2N7	KLH13_HUMAN	kelch-like 13	65					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				kidney(1)|skin(1)	2						ATGCGTGTAGGTCCTGCCTTG	0.458			NA											7	126					0.00198382	0.00237301	0.001984	1	0
XIAP	331	broad.mit.edu	37	X	123019764	123019764	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:123019764G>T	uc010nqu.2	+	2	378	c.252G>T	c.(250-252)AGG>AGT	p.R84S	XIAP_uc004etx.2_Missense_Mutation_p.R84S|XIAP_uc010nqv.2_Intron	NM_001167	NP_001158	P98170	XIAP_HUMAN	baculoviral IAP repeat-containing protein 4	84	BIR 1.				anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			ovary(1)|lung(1)	2						GAAGACACAGGAAAGTATCCC	0.423			NA							X-linked_Lymphoproliferative_syndrome				8	182					0.000157383	0.000210004	0.00308	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298618	125298618	+	Silent	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:125298618C>A	uc004euk.1	-	1	1317	c.1290G>T	c.(1288-1290)GCG>GCT	p.A430A		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	430										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GGGTGTAGAGCGCATTGGGGA	0.597			NA											21	197					1.96292e-10	3.76298e-10	0.001523	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298934	125298934	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:125298934G>C	uc004euk.1	-	1	1001	c.974C>G	c.(973-975)TCT>TGT	p.S325C		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	325										lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GTGGGACTGAGAGCCCACAGC	0.627			NA											9	149					0	0	0.004482	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128890485	128890485	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:128890485C>A	uc004eut.1	+	14	1565	c.1321C>A	c.(1321-1323)CTG>ATG	p.L441M		NM_003399	NP_003390	O43895	XPP2_HUMAN	X-prolyl aminopeptidase 2, membrane-bound	441					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0						GAACCGCAAGCTGTCCTCAGA	0.597			NA											8	119					2.17888e-05	3.2646e-05	0.006214	1	0
ZDHHC9	51114	broad.mit.edu	37	X	128975899	128975899	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:128975899T>A	uc004euv.2	-	2	392	c.23A>T	c.(22-24)AAG>ATG	p.K8M	ZDHHC9_uc004euw.2_Missense_Mutation_p.K8M|ZDHHC9_uc004eux.1_Missense_Mutation_p.K8M|ZDHHC9_uc004euy.1_Intron	NM_001008222	NP_001008223	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC domain containing 9	8	Cytoplasmic (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1						TGTCACCTTCTTTCTCACCAC	0.498			NA											10	219					0	0	0.008291	0	0
USP26	83844	broad.mit.edu	37	X	132159958	132159958	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:132159958C>A	uc010nrm.1	-	6	2761	c.2291G>T	c.(2290-2292)GGC>GTC	p.G764V	USP26_uc011mvf.1_Missense_Mutation_p.G764V	NM_031907	NP_114113	Q9BXU7	UBP26_HUMAN	ubiquitin-specific protease 26	764					protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(3)|central_nervous_system(3)|kidney(1)|liver(1)	8	Acute lymphoblastic leukemia(192;0.000127)					CCCCTGGGTGCCTGGCTTTGG	0.463	NSCLC(104;342 1621 36940 47097 52632)		NA											8	218					1.06961e-07	1.84866e-07	0.00308	1	0
GPC4	2239	broad.mit.edu	37	X	132438835	132438835	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:132438835G>T	uc004exc.1	-	7	1422	c.1210C>A	c.(1210-1212)CCG>ACG	p.P404T	GPC4_uc011mvg.1_Missense_Mutation_p.P334T	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	404					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					ACGTTGCTCGGAAGGGAGGAC	0.428			NA											16	232					1.99824e-07	3.4001e-07	0.00499	1	0
GPR112	139378	broad.mit.edu	37	X	135482265	135482265	+	Silent	SNP	A	A	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:135482265A>T	uc004ezu.1	+	21	8856	c.8565A>T	c.(8563-8565)CTA>CTT	p.L2855L	GPR112_uc010nsb.1_Silent_p.L2650L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	2855	Helical; Name=4; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AATTTTGTCTAGTTGGTTGGG	0.338			NA											11	164					0	0	0.000978	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717341	142717341	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:142717341C>A	uc004fbx.2	-	2	1960	c.1584G>T	c.(1582-1584)TTG>TTT	p.L528F	SLITRK4_uc004fby.2_Missense_Mutation_p.L528F	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	528	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GGTTGCCCTCCAAGTCAATCT	0.478			NA											11	274					3.07112e-06	4.88486e-06	0.000978	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904119	144904119	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:144904119C>A	uc004fcd.2	+	5	1166	c.176C>A	c.(175-177)CCC>CAC	p.P59H	SLITRK2_uc010nsp.2_Missense_Mutation_p.P59H|SLITRK2_uc010nso.2_Missense_Mutation_p.P59H|SLITRK2_uc011mwq.1_Missense_Mutation_p.P59H|SLITRK2_uc011mwr.1_Missense_Mutation_p.P59H|SLITRK2_uc011mws.1_Missense_Mutation_p.P59H|SLITRK2_uc004fcg.2_Missense_Mutation_p.P59H|SLITRK2_uc011mwt.1_Missense_Mutation_p.P59H	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	59	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTCCAGCCCCCCCAGTAT	0.428			NA											8	95					0.00307968	0.00362461	0.00308	1	0
MAGEA8	4107	broad.mit.edu	37	X	149013858	149013858	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:149013858G>A	uc004fdw.1	+	3	1027	c.812G>A	c.(811-813)CGC>CAC	p.R271H		NM_005364	NP_005355	P43361	MAGA8_HUMAN	melanoma antigen family A, 8	271	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					GATCCTGTGCGCTACGAGTTC	0.567			NA											11	240					0	0	0.001855	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482377	152482378	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:152482377_152482378CC>AA	uc004fhf.2	-	3	853_854	c.633_634GG>TT	c.(631-636)GAGGAG>GATTAG	p.211_212EE>D*		NM_004988	NP_004979	P43355	MAGA1_HUMAN	melanoma antigen family A, 1	211_212	MAGE.					cytoplasm|plasma membrane				central_nervous_system(7)|ovary(1)|lung(1)|breast(1)	10	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGATTTCCTCCTCAGGAGCAT	0.545			NA											6	162					0	0	0.004672	0	0
ATP2B3	492	broad.mit.edu	37	X	152807850	152807850	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:152807850C>G	uc004fht.1	+	4	860	c.734C>G	c.(733-735)ACG>AGG	p.T245R	ATP2B3_uc004fhs.1_Missense_Mutation_p.T245R	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	245	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCTCCCTGACGGGCGAGTCT	0.647			NA											6	58					0	0	0.001168	0	0
L1CAM	3897	broad.mit.edu	37	X	153141232	153141232	+	Silent	SNP	G	G	A			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:153141232G>A	uc004fjb.2	-	1	168	c.60C>T	c.(58-60)ATC>ATT	p.I20I	L1CAM_uc004fjc.2_Silent_p.I20I|L1CAM_uc010nuo.2_Silent_p.I20I|L1CAM_uc004fje.1_Silent_p.I20I	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	20	Extracellular (Potential).				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CGGGGATCTGGATAAGCAGGC	0.642			NA											3	42					0	0	0.004672	0	0
OPN1MW	2652	broad.mit.edu	37	X	153496193	153496193	+	Silent	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:153496193G>T	uc004fkd.2	+	5	1003	c.921G>T	c.(919-921)CCG>CCT	p.P307P		NM_000513	NP_000504	P04001	OPSG_HUMAN	opsin 1 (cone pigments), medium-wave-sensitive	307	Helical; Name=7; (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0	all_cancers(53;1.83e-16)|all_epithelial(53;2.73e-10)|all_lung(58;6.39e-07)|Lung NSC(58;8.37e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCCCTGCCGGCCTTCTTTG	0.537			NA											12	81					1.00905e-13	2.06033e-13	0.008871	1	0
TKTL1	8277	broad.mit.edu	37	X	153551614	153551614	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:153551614G>T	uc004fkg.2	+	9	1434	c.1248G>T	c.(1246-1248)AAG>AAT	p.K416N	TKTL1_uc011mzl.1_Missense_Mutation_p.K410N|TKTL1_uc011mzm.1_Missense_Mutation_p.K212N|TKTL1_uc004fkh.2_Missense_Mutation_p.K360N	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	416					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCATTCCCAAGTGCACGATCT	0.522			NA											12	185					4.3838e-07	7.28973e-07	0.001855	1	0
LCE5A	254910	broad.mit.edu	37	1	152484167	152484167	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:152484167delG	uc001ezy.2	+	2	333	c.157delG	c.(157-159)GGTfs	p.G53fs	CRCT1_uc001ezz.2_5'Flank	NM_178438	NP_848525	Q5TCM9	LCE5A_HUMAN	late cornified envelope 5A	53	Cys-rich.				keratinization					ovary(1)	1	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCTGCTGTGGTTCCAGCTC	0.517			NA											12	137	---	---	---	---	NA	NA	NA	NA	NA
RYR2	6262	broad.mit.edu	37	1	237666676	237666676	+	Frame_Shift_Del	DEL	A	A	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr1:237666676delA	uc001hyl.1	+	22	2604	c.2484delA	c.(2482-2484)CCAfs	p.P828fs		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	828	Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGTTCTGCCAAAAGAAAAGT	0.493			NA											10	70	---	---	---	---	NA	NA	NA	NA	NA
PDCD11	22984	broad.mit.edu	37	10	105198508	105198508	+	Frame_Shift_Del	DEL	A	A	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr10:105198508delA	uc001kwy.1	+	27	4055	c.3968delA	c.(3967-3969)GAAfs	p.E1323fs		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1323					mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GACATTAAGGAAGGGCAGCTT	0.507			NA											8	121	---	---	---	---	NA	NA	NA	NA	NA
VWF	7450	broad.mit.edu	37	12	6078534	6078535	+	Frame_Shift_Ins	INS	-	-	G			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr12:6078534_6078535insG	uc001qnn.1	-	45	7821_7822	c.7571_7572insC	c.(7570-7572)CCGfs	p.P2524fs	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	2524					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	AGGGGTTCTCCGGGGAGGCCCA	0.604			NA											9	85	---	---	---	---	NA	NA	NA	NA	NA
RAMP2	10266	broad.mit.edu	37	17	40914762	40914762	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr17:40914762delC	uc002ibg.2	+	4	488	c.420delC	c.(418-420)GACfs	p.D140fs	LOC100190938_uc002ibd.1_5'Flank|LOC100190938_uc002ibe.3_5'Flank|LOC100190938_uc002ibf.3_5'Flank|RAMP2_uc010cyt.2_Frame_Shift_Del_p.D145fs|RAMP2_uc002ibh.2_Frame_Shift_Del_p.T104fs	NM_005854	NP_005845	O60895	RAMP2_HUMAN	receptor activity modifying protein 2 precursor	140	Extracellular (Potential).				intracellular protein transport|receptor-mediated endocytosis|regulation of G-protein coupled receptor protein signaling pathway	coated pit|integral to plasma membrane|lysosome	protein transporter activity				0		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0741)	Pramlintide(DB01278)	CCTTCTCTGACCCCCCAGAGG	0.552			NA											7	89	---	---	---	---	NA	NA	NA	NA	NA
SDPR	8436	broad.mit.edu	37	2	192700826	192700826	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr2:192700826delC	uc002utb.2	-	2	1431	c.1101delG	c.(1099-1101)GGGfs	p.G367fs		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	367						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TGCTGTCCATCCCCGAGTTAC	0.582			NA											9	298	---	---	---	---	NA	NA	NA	NA	NA
MYH15	22989	broad.mit.edu	37	3	108102463	108102463	+	Frame_Shift_Del	DEL	T	T	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:108102463delT	uc003dxa.1	-	41	5862	c.5805delA	c.(5803-5805)AAAfs	p.K1935fs		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	1935	Potential.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						ACTCTCTTGCTTTAATTTTGA	0.368			NA											44	348	---	---	---	---	NA	NA	NA	NA	NA
STXBP5L	9515	broad.mit.edu	37	3	121126216	121126216	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr3:121126216delG	uc003eec.3	+	24	2926	c.2786delG	c.(2785-2787)TGGfs	p.W929fs	STXBP5L_uc011bji.1_Frame_Shift_Del_p.W905fs	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	929	WD 12.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		GAAAAATCTTGGAGAAGGAAA	0.393			NA											21	120	---	---	---	---	NA	NA	NA	NA	NA
IQGAP2	10788	broad.mit.edu	37	5	75964638	75964638	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr5:75964638delC	uc003kek.2	+	23	3034	c.2812delC	c.(2812-2814)CTTfs	p.L938fs	IQGAP2_uc010izv.2_Frame_Shift_Del_p.L491fs|IQGAP2_uc011csv.1_Frame_Shift_Del_p.L434fs|IQGAP2_uc003kel.2_Frame_Shift_Del_p.L434fs	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	938	Ras-GAP.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACTTCTCAAGCTTTTTAAAAC	0.333			NA											8	98	---	---	---	---	NA	NA	NA	NA	NA
PKHD1	5314	broad.mit.edu	37	6	51890920	51890920	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr6:51890920delC	uc003pah.1	-	32	3964	c.3688delG	c.(3688-3690)GTAfs	p.V1230fs	PKHD1_uc003pai.2_Frame_Shift_Del_p.V1230fs	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	1230	Extracellular (Potential).|IPT/TIG 7.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCCACAAGTACCCAAACCAAA	0.517			NA											10	104	---	---	---	---	NA	NA	NA	NA	NA
HOXA2	3199	broad.mit.edu	37	7	27141898	27141899	+	Frame_Shift_Ins	INS	-	-	T			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chr7:27141898_27141899insT	uc003syh.2	-	1	496_497	c.221_222insA	c.(220-222)AAGfs	p.K74fs		NM_006735	NP_006726	O43364	HXA2_HUMAN	homeobox A2	74						nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						cggggcTCGGCTTGGGGCGGCC	0.5			NA											5	9	---	---	---	---	NA	NA	NA	NA	NA
RGAG1	57529	broad.mit.edu	37	X	109695829	109695829	+	Frame_Shift_Del	DEL	G	G	-			TCGA-38-4626-01A-01D-1553-08	TCGA-38-4626-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	85b56ce7-b420-433e-a77d-43ef628d685c	4443344e-b4c7-48a7-9b46-05fbe1c32326	g.chrX:109695829delG	uc004eor.1	+	3	2230	c.1984delG	c.(1984-1986)GCCfs	p.A662fs	RGAG1_uc011msr.1_Frame_Shift_Del_p.A662fs	NM_020769	NP_065820	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	662										lung(2)|upper_aerodigestive_tract(1)|ovary(1)	4						GACAGACACAGCCTCTGGAGG	0.512			NA											7	107	---	---	---	---	NA	NA	NA	NA	NA