Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CSMD2	114784	broad.mit.edu	37	1	34071024	34071024	+	Silent	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr1:34071024G>A	uc001bxn.1	-	43	6425	c.6396C>T	c.(6394-6396)GGC>GGT	p.G2132G	CSMD2_uc001bxm.1_Silent_p.G2130G|CSMD2_uc001bxo.1_Silent_p.G1003G	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2132	Sushi 12.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCTCACAATGCCATTGGCAA	0.507			NA											9	82					0	0	0.058154	0	0
CD34	947	broad.mit.edu	37	1	208073342	208073342	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr1:208073342C>T	uc001hgw.1	-	2	344	c.86G>A	c.(85-87)GGG>GAG	p.G29E	CD34_uc001hgx.1_Missense_Mutation_p.G29E|CD34_uc010psj.1_5'UTR	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	29					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						ACTCATGAACCCAGAAGCTAT	0.423			NA											10	55					0	0	0.058154	0	0
RAG1	5896	broad.mit.edu	37	11	36597479	36597479	+	Silent	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr11:36597479C>T	uc001mwu.3	+	2	2749	c.2625C>T	c.(2623-2625)TCC>TCT	p.S875S	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	875					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TAATTCCTTCCGAGGAGAGGC	0.483	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				15	123					0	0	0.0333	0	0
OR5D14	219436	broad.mit.edu	37	11	55563607	55563608	+	Missense_Mutation	DNP	TG	TG	AT	rs144571267	byFrequency	TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr11:55563607_55563608TG>AT	uc010rim.1	+	1	576_577	c.576_577TG>AT	c.(574-579)TCTGAT>TCATAT	p.D193Y		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				TGTCTGGCTCTGATATACTCAT	0.431			NA											34	372					0	0	0.004672	0	0
ALX1	8092	broad.mit.edu	37	12	85677431	85677431	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr12:85677431G>A	uc001tae.3	+	2	312	c.308G>A	c.(307-309)CGA>CAA	p.R103Q		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	103					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		AACAGTCTCCGAATGTCTCCC	0.478			NA											10	84					0	0	0.09319	0	0
KLHL1	57626	broad.mit.edu	37	13	70314633	70314633	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr13:70314633G>T	uc001vip.2	-	8	2489	c.1695C>A	c.(1693-1695)AGC>AGA	p.S565R	KLHL1_uc010thm.1_Missense_Mutation_p.S504R	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	565	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TATTCAGATAGCTCCAGCCAT	0.388			NA											10	116					3.86212e-05	4.70171e-05	0.069234	1	0
OR4K17	390436	broad.mit.edu	37	14	20586121	20586121	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr14:20586121C>T	uc001vwo.1	+	1	556	c.556C>T	c.(556-558)CAC>TAC	p.H186Y		NM_001004715	NP_001004715	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GGGTCTCCTTCACTCAGGGTT	0.453			NA											33	285					0	0	0.045705	0	0
OR10G3	26533	broad.mit.edu	37	14	22038086	22038086	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr14:22038086C>G	uc010tmb.1	-	1	790	c.790G>C	c.(790-792)GAA>CAA	p.E264Q		NM_001005465	NP_001005465	Q8NGC4	O10G3_HUMAN	olfactory receptor, family 10, subfamily G,	264	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;0.000987)			GBM - Glioblastoma multiforme(265;0.0139)		CTGTTGGTTTCAGGCCTCAGG	0.582			NA											4	149					0	0	0.009096	0	0
SERPINA6	866	broad.mit.edu	37	14	94780977	94780977	+	Silent	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr14:94780977G>A	uc001ycv.2	-	2	113	c.9C>T	c.(7-9)CTC>CTT	p.L3L	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	3					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TGTACAGGAGGAGTGGCATTG	0.458			NA											12	143					0	0	0.09319	0	0
MKL2	57496	broad.mit.edu	37	16	14340356	14340356	+	Silent	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr16:14340356G>A	uc010uza.1	+	12	1394	c.1239G>A	c.(1237-1239)AAG>AAA	p.K413K	MKL2_uc002dcg.2_Silent_p.K413K|MKL2_uc002dcj.2_5'Flank	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	402	SAP.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						CAGAACTGAAGTTAAGGGGTC	0.498			NA											3	75					0	0	0.004672	0	0
CHD9	80205	broad.mit.edu	37	16	53326814	53326814	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr16:53326814G>A	uc002ehb.2	+	28	5524	c.5360G>A	c.(5359-5361)CGT>CAT	p.R1787H	CHD9_uc002egy.2_Missense_Mutation_p.R1787H|CHD9_uc002ehc.2_Missense_Mutation_p.R1787H|CHD9_uc002ehf.2_Missense_Mutation_p.R901H|CHD9_uc010cbw.2_Missense_Mutation_p.R155H	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	1787					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CGTTTGAGGCGTCTCATCACT	0.388			NA											26	140					0	0	0.0918	0	0
ITGAE	3682	broad.mit.edu	37	17	3638115	3638115	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr17:3638115T>A	uc002fwo.3	-	21	2750	c.2651A>T	c.(2650-2652)CAA>CTA	p.Q884L		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	884	Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AGTCACCTTTTGCATCCTCTT	0.557	NSCLC(182;635 2928 8995 38788)		NA											27	243					0	0	0.108266	0	0
POLR2A	5430	broad.mit.edu	37	17	7416688	7416688	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr17:7416688C>T	uc002ghf.3	+	29	5339	c.5105C>T	c.(5104-5106)ACA>ATA	p.T1702I		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1702	16.|52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN].				mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				tactcaccgacatctcccagc	0			NA											5	19					0	0	0.014758	0	0
SEPT4	5414	broad.mit.edu	37	17	56606477	56606477	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr17:56606477C>A	uc002iwm.1	-	1	187	c.59G>T	c.(58-60)GGG>GTG	p.G20V	SEPT4_uc002iwk.1_5'Flank|SEPT4_uc010wnw.1_5'Flank|SEPT4_uc002iwl.1_5'Flank|SEPT4_uc002iwn.1_Missense_Mutation_p.G20V|SEPT4_uc002iwo.1_Intron|SEPT4_uc002iwp.1_Intron|SEPT4_uc010wnx.1_Intron|SEPT4_uc010wny.1_Intron|SEPT4_uc010dcy.1_Intron	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	20					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCACCTTACCCCAGCTTCAGT	0.552			NA											5	83					0.00116845	0.00139219	0.021553	1	0
BCAS3	54828	broad.mit.edu	37	17	59024579	59024579	+	Splice_Site	SNP	G	G	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr17:59024579G>T	uc002iyv.3	+	14	1197	c.1088_splice	c.e14-1	p.G363_splice	BCAS3_uc010wow.1_Splice_Site_p.G150_splice|BCAS3_uc002iyu.3_Splice_Site_p.G363_splice|BCAS3_uc002iyw.3_Splice_Site_p.G359_splice|BCAS3_uc002iyx.1_Splice_Site_p.G178_splice|BCAS3_uc002iyy.3_Splice_Site_p.G134_splice	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1							nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			TTGTCTTCCAGGAATGCTTCT	0.353			NA											24	250					1.77063e-15	2.25353e-15	0.108266	1	0
MC5R	4161	broad.mit.edu	37	18	13826014	13826014	+	Silent	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr18:13826014C>T	uc010xaf.1	+	1	250	c.250C>T	c.(250-252)CTG>TTG	p.L84L		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	84	Helical; Name=2; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GGCGGACATGCTGGTGAGCAT	0.522			NA											3	53					0	0	0.004672	0	0
U2AF2	11338	broad.mit.edu	37	19	56173908	56173908	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr19:56173908G>A	uc002qlu.2	+	6	1582	c.527G>A	c.(526-528)GGG>GAG	p.G176E	U2AF2_uc002qlt.2_Missense_Mutation_p.G176E	NM_007279	NP_009210	P26368	U2AF2_HUMAN	U2 (RNU2) small nuclear RNA auxiliary factor 2	176	RRM 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	nucleoplasm|spliceosomal complex	enzyme binding|nucleotide binding|RNA binding			ovary(1)	1		Colorectal(82;0.00244)|Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.107)		ATGCGCCTGGGGGGGCTGACC	0.458			NA											4	81					0	0	0.014758	0	0
TTN	7273	broad.mit.edu	37	2	179440815	179440815	+	Silent	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr2:179440815G>A	uc010zfg.1	-	275	62564	c.62340C>T	c.(62338-62340)GCC>GCT	p.A20780A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A14475A|TTN_uc010zfi.1_Silent_p.A14408A|TTN_uc010zfj.1_Silent_p.A14283A|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21707							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCGAAGCTCGGCATCTAGTT	0.468			NA											15	156					0	0	0.024245	0	0
PMS1	5378	broad.mit.edu	37	2	190742066	190742066	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr2:190742066C>G	uc002urh.3	+	13	3232	c.2703C>G	c.(2701-2703)ATC>ATG	p.I901M	PMS1_uc002urk.3_Missense_Mutation_p.I862M|PMS1_uc002uri.3_Missense_Mutation_p.I739M|PMS1_uc010zgc.1_Missense_Mutation_p.I725M|PMS1_uc010zgd.1_Missense_Mutation_p.I725M|PMS1_uc002urj.2_RNA|PMS1_uc010frz.2_Missense_Mutation_p.I217M|PMS1_uc002url.2_Missense_Mutation_p.I524M|PMS1_uc002urm.2_RNA	NM_000534	NP_000525	P54277	PMS1_HUMAN	postmeiotic segregation 1 isoform a	901					mismatch repair|reciprocal meiotic recombination	MutLalpha complex	ATP binding|ATPase activity|mismatched DNA binding			ovary(2)|kidney(1)|central_nervous_system(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0013)|Epithelial(96;0.0263)|all cancers(119;0.0751)			AAGACATTATCTACAGAATGA	0.378			NA	Mis|N			colorectal|endometrial|ovarian		Direct_reversal_of_damage|MMR					12	116					0	0	0.080935	0	0
HIRA	7290	broad.mit.edu	37	22	19398295	19398295	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr22:19398295G>A	uc002zpf.1	-	2	264	c.44C>T	c.(43-45)CCG>CTG	p.P15L	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.P15L|HIRA_uc010gro.1_5'UTR|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	15	WD 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TGAAAAAATCGGCTTGCCTGG	0.378			NA											34	293					0	0	0.074837	0	0
BPIL2	254240	broad.mit.edu	37	22	32833811	32833811	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr22:32833811A>T	uc003amn.2	-	7	683	c.683T>A	c.(682-684)CTG>CAG	p.L228Q	BPIL2_uc010gwo.2_Missense_Mutation_p.L42Q|BPIL2_uc011amb.1_5'UTR	NM_174932	NP_777592	Q8NFQ6	BPIL2_HUMAN	bactericidal/permeability-increasing	228						extracellular region	lipopolysaccharide binding|phospholipid binding			ovary(1)|skin(1)	2						GTAATCCAGCAGAGTGTAGTT	0.343			NA											8	79					0	0	0.047766	0	0
RASA2	5922	broad.mit.edu	37	3	141295935	141295935	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr3:141295935G>A	uc003etz.1	+	15	1577	c.1577G>A	c.(1576-1578)CGA>CAA	p.R526Q	RASA2_uc010huq.1_Missense_Mutation_p.R526Q|RASA2_uc003eua.1_Missense_Mutation_p.R526Q|RASA2_uc011bnc.1_Missense_Mutation_p.R118Q	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	526	Ras-GAP.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						TTTCATTTGCGACCTCATCAT	0.343			NA											21	204					0	0	0.099896	0	0
SLC9A9	285195	broad.mit.edu	37	3	143550932	143550932	+	Nonsense_Mutation	SNP	C	C	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr3:143550932C>A	uc003evn.2	-	2	489	c.307G>T	c.(307-309)GAA>TAA	p.E103*	SLC9A9_uc011bnk.1_Intron	NM_173653	NP_775924	Q8IVB4	SL9A9_HUMAN	solute carrier family 9 (sodium/hydrogen	103					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			ovary(2)|skin(1)	3						TATTTATATTCATAAACTTGG	0.338			NA											17	144					3.45872e-05	4.30418e-05	0.028581	1	0
CDC23	8697	broad.mit.edu	37	5	137527959	137527959	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr5:137527959G>A	uc003lcl.2	-	11	1316	c.1285C>T	c.(1285-1287)CGA>TGA	p.R429*		NM_004661	NP_004652	Q9UJX2	CDC23_HUMAN	cell division cycle protein 23	429	TPR 7.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G1 phase of mitotic cell cycle|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase plate congression|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of exit from mitosis	anaphase-promoting complex|cytosol|nucleoplasm	binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CAGGCTTACCGAAGCTGGTGG	0.438			NA											18	97					0	0	0.0333	0	0
PCDH1	5097	broad.mit.edu	37	5	141233671	141233671	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr5:141233671G>A	uc003llp.2	-	5	3767	c.3650C>T	c.(3649-3651)TCG>TTG	p.S1217L		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TGGGAAGTCCGAGGTCTGGGT	0.677	Ovarian(132;1609 1739 4190 14731 45037)		NA											4	14					0	0	0.014758	0	0
CDKAL1	54901	broad.mit.edu	37	6	20758841	20758841	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr6:20758841C>T	uc003ndc.1	+	7	658	c.484C>T	c.(484-486)CGT>TGT	p.R162C	CDKAL1_uc003ndd.1_Missense_Mutation_p.R162C|CDKAL1_uc003nde.1_Missense_Mutation_p.R92C	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	162	MTTase N-terminal.				RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			GCAGATAGATCGTGTGGTAGA	0.328			NA											7	66					0	0	0.047766	0	0
SLC17A1	6568	broad.mit.edu	37	6	25813423	25813423	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr6:25813423A>G	uc003nfh.3	-	7	751	c.635T>C	c.(634-636)GTA>GCA	p.V212A	SLC17A1_uc011djy.1_Intron|SLC17A1_uc010jqb.1_Missense_Mutation_p.V210A|SLC17A1_uc010jqc.1_Missense_Mutation_p.V210A	NM_005074	NP_005065	Q14916	NPT1_HUMAN	solute carrier family 17 (sodium phosphate),	212	Helical; (Potential).				sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			ovary(3)|pancreas(1)	4						GAGAAGACATACGGCACAGCC	0.438			NA											5	40					0	0	0.02938	0	0
PHF1	5252	broad.mit.edu	37	6	33380553	33380553	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr6:33380553G>A	uc003oeh.2	+	4	556	c.320G>A	c.(319-321)TGT>TAT	p.C107Y	PHF1_uc011drh.1_RNA|PHF1_uc003oei.2_Missense_Mutation_p.C107Y|PHF1_uc010jux.2_Intron	NM_024165	NP_077084	O43189	PHF1_HUMAN	PHD finger protein 1 isoform b	107	PHD-type 1.				chromatin modification	nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(999;0.0443)				CTGGTCAGCTGTGAGAAGTGT	0.577			NA											7	103					0	0	0.038147	0	0
TMEM106B	54664	broad.mit.edu	37	7	12270022	12270022	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr7:12270022A>G	uc011jxk.1	+	7	990	c.590A>G	c.(589-591)TAC>TGC	p.Y197C	TMEM106B_uc003ssh.2_Missense_Mutation_p.Y197C	NM_018374	NP_060844	Q9NUM4	T106B_HUMAN	transmembrane protein 106B	197				Y -> N (in Ref. 2; BAD96983).		integral to membrane					0				UCEC - Uterine corpus endometrioid carcinoma (126;0.185)		CAGATTGATTACACAGTACCT	0.264			NA											8	114					0	0	0.038147	0	0
EGFR	1956	broad.mit.edu	37	7	55210075	55210075	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr7:55210075T>G	uc003tqk.2	+	2	431	c.185T>G	c.(184-186)CTT>CGT	p.L62R	EGFR_uc003tqh.2_Missense_Mutation_p.L62R|EGFR_uc003tqi.2_Missense_Mutation_p.L62R|EGFR_uc003tqj.2_Missense_Mutation_p.L62R|EGFR_uc010kzg.1_Missense_Mutation_p.L62R|EGFR_uc011kco.1_Missense_Mutation_p.L9R	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	62	Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.V30_R297>G(5)|p.L62R(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GAGGTGGTCCTTGGGAATTTG	0.408			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			35	194					0	0	0.059317	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr7:55259515T>G	uc003tqk.2	+	21	2819	c.2573T>G	c.(2572-2574)CTG>CGG	p.L858R	EGFR_uc010kzg.1_Missense_Mutation_p.L813R|EGFR_uc011kco.1_Missense_Mutation_p.L805R|uc003tqo.2_5'Flank	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	858	Cytoplasmic (Potential).|Protein kinase.		L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).|L -> M (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(3429)|p.L858L(4)|p.L858M(4)|p.L858Q(3)|p.L858A(2)|p.L858W(1)|p.L858P(1)|p.L858K(1)|p.L858G(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537		L858R(NCIH1975_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			14	101					0	0	0.0333	0	0
Unknown	0	broad.mit.edu	37	7	100608884	100608884	+	Missense_Mutation	SNP	G	G	A	rs73163797	by1000genomes	TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr7:100608884G>A	uc003uxl.1	+	7	2763	c.1963G>A	c.(1963-1965)GCG>ACG	p.A655T	uc003uxm.1_RNA|uc003uxn.1_Intron|uc010lhn.1_RNA					SubName: Full=Intestinal mucin; Flags: Fragment;									p.A755T(1)			NA						GAGCGGTCCCGCGTGTCGGTA	0.667			NA											3	9					0	0	0.014758	0	0
ZNF425	155054	broad.mit.edu	37	7	148800831	148800831	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr7:148800831G>A	uc003wfj.2	-	4	2205	c.2132C>T	c.(2131-2133)GCC>GTC	p.A711V		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	711	C2H2-type 18.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GCACAGATGGGCCTTCAGGCT	0.557			NA											23	94					0	0	0.083992	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885731	88885731	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr8:88885731C>T	uc003ydz.2	-	1	566	c.469G>A	c.(469-471)GTG>ATG	p.V157M		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	157										ovary(1)	1						GGGAGCAGCACGGCACAGCTT	0.552			NA											7	109					0	0	0.038147	0	0
MXRA5	25878	broad.mit.edu	37	X	3235707	3235707	+	Silent	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chrX:3235707G>A	uc004crg.3	-	6	6172	c.6015C>T	c.(6013-6015)CAC>CAT	p.H2005H		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2005	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCCGGTTTTCGTGCAGGGTGA	0.622			NA											6	43					0	0	0.02938	0	0
DMD	1756	broad.mit.edu	37	X	31496381	31496381	+	Nonsense_Mutation	SNP	T	T	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chrX:31496381T>A	uc004dda.1	-	59	9023	c.8779A>T	c.(8779-8781)AGA>TGA	p.R2927*	DMD_uc004dcq.1_Nonsense_Mutation_p.R198*|DMD_uc004dcr.1_Nonsense_Mutation_p.R467*|DMD_uc004dcs.1_Nonsense_Mutation_p.R467*|DMD_uc004dct.1_Nonsense_Mutation_p.R467*|DMD_uc004dcu.1_Nonsense_Mutation_p.R467*|DMD_uc004dcv.1_Nonsense_Mutation_p.R467*|DMD_uc004dcw.2_Nonsense_Mutation_p.R1583*|DMD_uc004dcx.2_Nonsense_Mutation_p.R1586*|DMD_uc004dcz.2_Nonsense_Mutation_p.R2804*|DMD_uc004dcy.1_Nonsense_Mutation_p.R2923*|DMD_uc004ddb.1_Nonsense_Mutation_p.R2919*	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2927	Spectrin 21.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TCTATTTTTCTCTGCCAGTCA	0.527			NA											10	125					0	0	0.058154	0	0
G6PD	2539	broad.mit.edu	37	X	153764207	153764207	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chrX:153764207G>A	uc004fly.1	-	4	325	c.212C>T	c.(211-213)GCC>GTC	p.A71V	G6PD_uc004flx.1_Missense_Mutation_p.A101V	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	71					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCGGGAACGGGCATAGCCCAC	0.627			NA											4	56					0	0	0.009096	0	0
MYH3	4621	broad.mit.edu	37	17	10542739	10542739	+	Frame_Shift_Del	DEL	A	A	-			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr17:10542739delA	uc002gmq.1	-	23	3055	c.2978delT	c.(2977-2979)TTAfs	p.L993fs		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	993	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTCTCTGGTTAACTTTGCAAT	0.413			NA											11	90	---	---	---	---	NA	NA	NA	NA	NA
RUNDC1	146923	broad.mit.edu	37	17	41132982	41132982	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr17:41132982delC	uc002ici.1	+	1	401	c.389delC	c.(388-390)GCCfs	p.A130fs	AARSD1_uc002icd.2_5'Flank|AARSD1_uc002ice.2_5'Flank|AARSD1_uc002icf.2_5'Flank|AARSD1_uc010whg.1_5'Flank|AARSD1_uc002icg.2_5'Flank|AARSD1_uc002ich.2_5'Flank|AARSD1_uc010whh.1_5'Flank|RUNDC1_uc010whi.1_5'UTR	NM_173079	NP_775102	Q96C34	RUND1_HUMAN	RUN domain containing 1	130											0		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		GAAGACTTCGCCTTCCGCGGC	0.726			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
C8orf59	401466	broad.mit.edu	37	8	86129664	86129664	+	Frame_Shift_Del	DEL	T	T	-			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr8:86129664delT	uc010mac.1	-	3	305	c.65delA	c.(64-66)AACfs	p.N22fs	C8orf59_uc003ydd.2_Frame_Shift_Del_p.N22fs|C8orf59_uc010mad.1_Frame_Shift_Del_p.N22fs|C8orf59_uc003yde.2_Frame_Shift_Del_p.N22fs|C8orf59_uc011lfu.1_RNA	NM_001099670	NP_001093140	Q8N0T1	CH059_HUMAN	hypothetical protein LOC401466	22											0						AGCCTTAAAGTTTTTTTGGCT	0.343			NA											8	261	---	---	---	---	NA	NA	NA	NA	NA
PHF20L1	51105	broad.mit.edu	37	8	133855032	133855032	+	Frame_Shift_Del	DEL	T	T	-			TCGA-38-4627-01A-01D-1553-08	TCGA-38-4627-11A-01D-1553-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	abef97da-d7db-495f-b594-fa66577becd6	21d49f80-fd21-421f-a3bd-5f39b1ac3e48	g.chr8:133855032delT	uc003ytt.2	+	19	2985	c.2660delT	c.(2659-2661)GTTfs	p.V887fs	PHF20L1_uc011lja.1_Frame_Shift_Del_p.V861fs	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	887							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GATGATGATGTTAGTAGTTTG	0.383			NA											18	208	---	---	---	---	NA	NA	NA	NA	NA