Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10713525	10713525	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:10713525C>T	uc001aro.2	-	11	2909	c.2589G>A	c.(2587-2589)ATG>ATA	p.M863I	CASZ1_uc001arp.1_Missense_Mutation_p.M863I|CASZ1_uc009vmx.2_Missense_Mutation_p.M887I	NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	863					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		AGATCCTCTCCATGATGGAGG	0.672			NA											4	41					0	0	0.00116845	0	0
LPHN2	23266	broad.mit.edu	37	1	82417722	82417722	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:82417722A>C	uc001dit.3	+	9	1859	c.1678A>C	c.(1678-1680)AGT>CGT	p.S560R	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.S560R|LPHN2_uc001div.2_Missense_Mutation_p.S560R|LPHN2_uc009wcd.2_Missense_Mutation_p.S560R|LPHN2_uc001diw.2_Missense_Mutation_p.S131R	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	560	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TGGGGATGTAAGTTCTTCAGT	0.433			NA											4	31					0	0	0.000602214	0	0
COL11A1	1301	broad.mit.edu	37	1	103468348	103468348	+	Splice_Site	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:103468348C>T	uc001dul.2	-	22	2317	c.1999_splice	c.e22-1	p.G667_splice	COL11A1_uc001duk.2_Splice_Site|COL11A1_uc001dum.2_Splice_Site_p.G679_splice|COL11A1_uc001dun.2_Splice_Site_p.G628_splice|COL11A1_uc009weh.2_Splice_Site_p.G551_splice	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGCCATACCCTGCAATGAAG	0.343			NA											5	27					0	0	0.000442599	0	0
PBXIP1	57326	broad.mit.edu	37	1	154919177	154919177	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:154919177G>A	uc001ffr.2	-	10	1032	c.973C>T	c.(973-975)CGG>TGG	p.R325W	PBXIP1_uc001ffs.2_Missense_Mutation_p.R296W|PBXIP1_uc010pep.1_Missense_Mutation_p.R170W	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein	325	Potential.				cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TCCAGAGCCCGCTGGAAGGCT	0.672			NA											16	13					0	0	0.000422831	0	0
CLK2	1196	broad.mit.edu	37	1	155240629	155240629	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:155240629C>T	uc001fjy.2	-	2	430	c.140G>A	c.(139-141)CGA>CAA	p.R47Q	RAG1AP1_uc010pey.1_Intron|CLK2_uc001fjw.2_Missense_Mutation_p.R47Q|CLK2_uc001fjx.2_5'UTR|CLK2_uc009wqm.2_Missense_Mutation_p.R47Q	NM_003993	NP_003984	P49760	CLK2_HUMAN	CDC-like kinase 2	47						nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GCTGTCCTCTCGCCGACGCCG	0.527			NA						Other_conserved_DNA_damage_response_genes					61	153					0	0	0.000781405	0	0
VAMP4	8674	broad.mit.edu	37	1	171679944	171679944	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:171679944G>C	uc001ghx.1	-	5	389	c.175C>G	c.(175-177)CAA>GAA	p.Q59E	VAMP4_uc001ghw.1_RNA|VAMP4_uc001ghy.1_Missense_Mutation_p.Q58E|VAMP4_uc001ghv.1_5'Flank	NM_003762	NP_003753	O75379	VAMP4_HUMAN	vesicle-associated membrane protein 4	59	Cytoplasmic (Potential).|v-SNARE coiled-coil homology.				vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome					0	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TCATCCACTTGATTCTGAACA	0.303			NA											6	105					0	0	0.000157383	0	0
PAPPA2	60676	broad.mit.edu	37	1	176563941	176563941	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:176563941G>A	uc001gkz.2	+	3	2365	c.1201G>A	c.(1201-1203)GCA>ACA	p.A401T	PAPPA2_uc001gky.1_Missense_Mutation_p.A401T|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	401					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						CCCCTTCATGGCATCTTGCCG	0.602			NA											13	93					0	0	0.000219431	0	0
LAMC2	3918	broad.mit.edu	37	1	183190037	183190037	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:183190037C>G	uc001gqa.2	+	5	895	c.581C>G	c.(580-582)GCC>GGC	p.A194G	LAMC2_uc001gpz.3_Missense_Mutation_p.A194G|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	194	Laminin EGF-like 4; first part.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						GGGCATTCAGCCAGCTGCCGC	0.453			NA											4	59					0	0	0.00024832	0	0
CAMSAP1L1	23271	broad.mit.edu	37	1	200817373	200817373	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:200817373A>G	uc001gvl.2	+	12	1779	c.1509A>G	c.(1507-1509)ATA>ATG	p.I503M	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.I492M|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.I476M	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	503						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						AACTTAATATAGATTCTCACA	0.343			NA											36	72					0	0	0.000953801	0	0
OR13G1	441933	broad.mit.edu	37	1	247836182	247836182	+	Silent	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr1:247836182C>A	uc001idi.1	-	1	162	c.162G>T	c.(160-162)ACG>ACT	p.T54T		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	54	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CATACATGGGCGTATGCAAGG	0.418			NA											10	34					2.17888e-05	0.000121836	0.000442599	1	0
TUBB8	347688	broad.mit.edu	37	10	93320	93320	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:93320T>A	uc001ifi.2	-	4	1012	c.1012A>T	c.(1012-1014)AGC>TGC	p.S338C	TUBB8_uc009xhe.2_Missense_Mutation_p.S301C|TUBB8_uc010pzs.1_Missense_Mutation_p.S266C	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	338					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		AAGTAACTGCTGTTCTTATCT	0.527	Pancreas(192;2041 3010 9013 18103)		NA											41	103					0	0	0.00148497	0	0
ADARB2	105	broad.mit.edu	37	10	1405829	1405830	+	Missense_Mutation	DNP	CG	CG	TT			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:1405829_1405830CG>TT	uc009xhq.2	-	3	844_845	c.470_471CG>AA	c.(469-471)GCG>GAA	p.A157E		NM_018702	NP_061172	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2	157	DRBM 1.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CCACCGCTACCGCGAAGACCGG	0.688			NA											4	24					0	0	6.4e-05	0	0
GPR158	57512	broad.mit.edu	37	10	25887907	25887907	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:25887907G>T	uc001isj.2	+	11	3412	c.3352G>T	c.(3352-3354)GAA>TAA	p.E1118*	GPR158_uc001isk.2_Nonsense_Mutation_p.E493*	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1118	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						TGGGCAGAGCGAAGAACTGCC	0.473			NA											10	92					1.76689e-08	1.05385e-07	0.000442599	1	0
MYO3A	53904	broad.mit.edu	37	10	26414396	26414396	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:26414396G>A	uc001isn.2	+	19	2333	c.1973G>A	c.(1972-1974)AGA>AAA	p.R658K	MYO3A_uc009xko.1_Missense_Mutation_p.R658K|MYO3A_uc009xkp.1_RNA|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	658	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity	p.R658G(1)		ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						GTGGTCACTAGAGGAGAAACA	0.428			NA											9	93					0	0	0.000442599	0	0
ABI1	10006	broad.mit.edu	37	10	27060003	27060003	+	Splice_Site	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:27060003C>A	uc001isx.2	-	4	644	c.477_splice	c.e4+1	p.K159_splice	ABI1_uc001ite.2_Intron|ABI1_uc010qdh.1_Intron|ABI1_uc010qdi.1_Intron|ABI1_uc001isy.2_Splice_Site_p.K159_splice|ABI1_uc001ita.2_Splice_Site_p.K159_splice|ABI1_uc001isz.2_Intron|ABI1_uc001itb.2_Splice_Site_p.K176_splice|ABI1_uc001itc.2_Splice_Site_p.K159_splice|ABI1_uc010qdj.1_Splice_Site_p.K159_splice|ABI1_uc001itd.2_Splice_Site_p.K159_splice|ABI1_uc010qdk.1_Splice_Site_p.K159_splice|ABI1_uc010qdg.1_Intron	NM_005470	NP_005461	Q8IZP0	ABI1_HUMAN	abl-interactor 1 isoform a						actin polymerization or depolymerization|cellular component movement|negative regulation of cell proliferation|peptidyl-tyrosine phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	cell junction|cytoskeleton|cytosol|endoplasmic reticulum|filopodium|growth cone|lamellipodium|nucleus|soluble fraction|synapse|synaptosome	cytoskeletal protein binding			central_nervous_system(1)	1						ATGGCTCTTACCTTGGCTTTT	0.383			NA											8	32					0.000157383	0.000865608	0.000157383	1	0
MTPAP	55149	broad.mit.edu	37	10	30615549	30615549	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:30615549G>A	uc001iva.3	-	5	859	c.796C>T	c.(796-798)CTG>TTG	p.L266L	MTPAP_uc001ivb.3_Silent_p.L396L	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	266					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						AATTCCATCAGAAAATTTCCT	0.338			NA											15	97					0	0	0.000308642	0	0
PCDH15	65217	broad.mit.edu	37	10	55755520	55755520	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:55755520C>T	uc001jju.1	-	21	3152	c.2757G>A	c.(2755-2757)ATG>ATA	p.M919I	PCDH15_uc010qhq.1_Missense_Mutation_p.M924I|PCDH15_uc010qhr.1_Missense_Mutation_p.M919I|PCDH15_uc010qhs.1_Missense_Mutation_p.M931I|PCDH15_uc010qht.1_Missense_Mutation_p.M926I|PCDH15_uc010qhu.1_Missense_Mutation_p.M919I|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.M919I|PCDH15_uc010qhw.1_Missense_Mutation_p.M882I|PCDH15_uc010qhx.1_Missense_Mutation_p.M848I|PCDH15_uc010qhy.1_Missense_Mutation_p.M924I|PCDH15_uc010qhz.1_Missense_Mutation_p.M919I|PCDH15_uc010qia.1_Missense_Mutation_p.M897I|PCDH15_uc010qib.1_Missense_Mutation_p.M897I|PCDH15_uc001jjw.2_Missense_Mutation_p.M919I	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	919	Extracellular (Potential).|Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GATAATCATTCATATCCTGTA	0.393			NA								HNSCC(58;0.16)			10	22					0	0	0.000442599	0	0
STOX1	219736	broad.mit.edu	37	10	70641845	70641845	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:70641845C>T	uc001jos.2	+	2	529	c.442C>T	c.(442-444)CGT>TGT	p.R148C	STOX1_uc001jor.2_Missense_Mutation_p.R148C|STOX1_uc009xpy.2_Missense_Mutation_p.R148C|STOX1_uc001joq.2_Missense_Mutation_p.R38C	NM_001130161	NP_001123633	Q6ZVD7	STOX1_HUMAN	storkhead box 1 isoform a	148						cytoplasm|nucleolus	DNA binding			kidney(1)|skin(1)	2						ACTTTTGGAGCGTTTGATGAA	0.343			NA											12	75					0	0	0.000422831	0	0
DDX50	79009	broad.mit.edu	37	10	70706252	70706252	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:70706252G>A	uc001jou.2	+	15	2187	c.2080G>A	c.(2080-2082)GGT>AGT	p.G694S	DDX50_uc010qjc.1_Intron	NM_024045	NP_076950	Q9BQ39	DDX50_HUMAN	nucleolar protein GU2	694	Arg-rich.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1						AGGCCGGTCAGGTGGTCGATC	0.498			NA											6	41					0	0	0.00116845	0	0
SAMD8	142891	broad.mit.edu	37	10	76910337	76910337	+	Silent	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:76910337A>G	uc001jwx.1	+	2	154	c.51A>G	c.(49-51)GTA>GTG	p.V17V	SAMD8_uc001jwy.1_Silent_p.V17V	NM_144660	NP_653261	Q96LT4	SAMD8_HUMAN	sterile alpha motif domain containing 8	17	SAM.				sphingomyelin biosynthetic process	integral to membrane					0	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					CCAAGCATGTAGCTGTGTGGC	0.433			NA											20	56					0	0	0.00121646	0	0
DLG5	9231	broad.mit.edu	37	10	79553773	79553773	+	Nonsense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:79553773G>T	uc001jzk.2	-	31	5719	c.5649C>A	c.(5647-5649)TAC>TAA	p.Y1883*	DLG5_uc001jzi.2_Nonsense_Mutation_p.Y638*|DLG5_uc001jzj.2_Nonsense_Mutation_p.Y1298*	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1883	Guanylate kinase-like.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TACCTGTGAAGTACCTGCTGT	0.577			NA											12	79					5.50884e-06	3.11935e-05	0.00136819	1	0
NRG3	10718	broad.mit.edu	37	10	84744862	84744862	+	Missense_Mutation	SNP	C	C	T	rs150723859		TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:84744862C>T	uc001kco.2	+	9	1619	c.1592C>T	c.(1591-1593)TCC>TTC	p.S531F	NRG3_uc010qlz.1_Missense_Mutation_p.S530F|NRG3_uc001kcp.2_Missense_Mutation_p.S334F|NRG3_uc001kcq.2_Missense_Mutation_p.S181F|NRG3_uc001kcr.2_Missense_Mutation_p.S205F	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	555	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AGGTATTCATCCAGTGGTTTA	0.303			NA											61	180					0	0	0.000781405	0	0
NEURL	9148	broad.mit.edu	37	10	105349409	105349409	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:105349409C>G	uc001kxh.2	+	5	1888	c.1478C>G	c.(1477-1479)TCT>TGT	p.S493C	SH3PXD2A_uc010qqr.1_Intron	NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	493					nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CTGGGTAGCTCTGCTGGTGGT	0.652			NA											8	75					0	0	0.000274275	0	0
SORCS1	114815	broad.mit.edu	37	10	108434901	108434901	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:108434901C>T	uc001kym.2	-	14	1854	c.1846G>A	c.(1846-1848)GAA>AAA	p.E616K	SORCS1_uc001kyl.2_Missense_Mutation_p.E616K|SORCS1_uc009xxs.2_Missense_Mutation_p.E616K|SORCS1_uc001kyn.1_Missense_Mutation_p.E616K|SORCS1_uc001kyo.2_Missense_Mutation_p.E616K	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	616	Lumenal (Potential).|BNR 5.					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GATCTCCCTTCATCAAAACTC	0.378			NA											5	56					0	0	0.000602214	0	0
C10orf118	55088	broad.mit.edu	37	10	115922598	115922598	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:115922598C>G	uc001lbb.1	-	2	1082	c.430G>C	c.(430-432)GAC>CAC	p.D144H	C10orf118_uc001lbc.1_Missense_Mutation_p.D144H|C10orf118_uc009xye.1_RNA|C10orf118_uc001lbd.2_Missense_Mutation_p.D144H|C10orf118_uc001lbe.2_Missense_Mutation_p.D144H	NM_018017	NP_060487	Q7Z3E2	CJ118_HUMAN	CTCL tumor antigen L14-2	144										ovary(2)	2		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		TTGGTGCAGTCTGTATCATAG	0.353			NA											13	101					0	0	0.00185496	0	0
PNLIP	5406	broad.mit.edu	37	10	118306878	118306878	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr10:118306878C>A	uc001lcm.2	+	3	162	c.119C>A	c.(118-120)CCC>CAC	p.P40H		NM_000936	NP_000927	P16233	LIPP_HUMAN	pancreatic lipase precursor	40					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|skin(1)	3				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	ACGGAAAGACCCCTCCATATA	0.438			NA											5	56					0.000602214	0.00325876	0.000602214	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16863240	16863240	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:16863240G>C	uc001mmo.2	-	9	741	c.726C>G	c.(724-726)ATC>ATG	p.I242M	PLEKHA7_uc010rcu.1_Missense_Mutation_p.I242M	NM_175058	NP_778228	Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A	242	PH.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			skin(2)|central_nervous_system(1)	3						AGCTGTTATAGATGAGCGCTC	0.552			NA											3	44					0	0	0.00024832	0	0
SAAL1	113174	broad.mit.edu	37	11	18110877	18110877	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:18110877C>A	uc001mnq.2	-	7	820	c.770G>T	c.(769-771)CGT>CTT	p.R257L	SAAL1_uc001mnr.2_Missense_Mutation_p.R257L|SAAL1_uc001mns.2_RNA|SAAL1_uc009yhf.2_Missense_Mutation_p.R257L	NM_138421	NP_612430	Q96ER3	SAAL1_HUMAN	serum amyloid A-like 1	257					acute-phase response	extracellular region	binding				0						GCTCACCTACCGTACTTGTTT	0.433			NA											14	56					1.05317e-09	6.54331e-09	0.000219431	1	0
EIF3M	10480	broad.mit.edu	37	11	32610279	32610279	+	Splice_Site	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:32610279G>A	uc001mtu.2	+	3	357	c.314_splice	c.e3+1	p.L105_splice	EIF3M_uc010ref.1_Intron	NM_006360	NP_006351	Q7L2H7	EIF3M_HUMAN	eukaryotic translation initiation factor 3,							eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)|breast(1)|skin(1)	3	Breast(20;0.109)					GACTGCAGTTGTAAGTTAAGA	0.323			NA											23	71					0	0	0.000375601	0	0
RAG1	5896	broad.mit.edu	37	11	36597777	36597777	+	Silent	SNP	C	C	A	rs121918570		TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:36597777C>A	uc001mwu.3	+	2	3047	c.2923C>A	c.(2923-2925)CGG>AGG	p.R975R	RAG1_uc001mwt.2_Intron	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	975			R -> W (in CHIDG; reduced recombination activity).|R -> Q (in OS).		histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				TAGGCGCTTCCGGAAAATGAA	0.473	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				14	76					2.32078e-09	1.43525e-08	0.000308642	1	0
FNBP4	23360	broad.mit.edu	37	11	47754218	47754218	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:47754218C>G	uc009ylv.2	-	11	1844	c.1691G>C	c.(1690-1692)CGA>CCA	p.R564P	FNBP4_uc001ngj.2_Missense_Mutation_p.R471P|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	564										ovary(1)	1						GTCTGCAATTCGAGTCTAGAA	0.398			NA											5	30					0	0	0.00116845	0	0
OR4C16	219428	broad.mit.edu	37	11	55339900	55339900	+	Silent	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:55339900C>A	uc010rih.1	+	1	297	c.297C>A	c.(295-297)GTC>GTA	p.V99V		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	99	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TGATCCAAGTCTTTTCATCCC	0.473			NA											32	206					6.00712e-18	3.95174e-17	0.000409698	1	0
STX5	6811	broad.mit.edu	37	11	62591939	62591939	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:62591939C>G	uc001nvh.2	-	9	932	c.778G>C	c.(778-780)GAC>CAC	p.D260H	STX5_uc010rmi.1_Missense_Mutation_p.D164H|STX5_uc009yoh.2_RNA|STX5_uc001nvi.2_Missense_Mutation_p.D206H|STX5_uc010rmj.1_Missense_Mutation_p.D260H|STX5_uc001nvj.2_Missense_Mutation_p.D75H	NM_003164	NP_003155	Q13190	STX5_HUMAN	syntaxin 5	260	Cytoplasmic (Potential).				intracellular protein transport|retrograde transport, endosome to Golgi|vesicle targeting	ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|nucleus|SNARE complex	protein N-terminus binding|SNAP receptor activity			ovary(1)|breast(1)	2						ACCTGCTCGTCAATGAGCTGC	0.572			NA											10	85					0	0	0.000978159	0	0
DPF2	5977	broad.mit.edu	37	11	65113187	65113187	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:65113187C>T	uc001odm.2	+	7	700	c.688C>T	c.(688-690)CAC>TAC	p.H230Y	DPF2_uc001odn.2_Missense_Mutation_p.H244Y|DPF2_uc010roe.1_Intron	NM_006268	NP_006259	Q92785	REQU_HUMAN	D4, zinc and double PHD fingers family 2	230	C2H2-type.				apoptosis|induction of apoptosis by extracellular signals|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						CCACTATGCCCACTCCCACTT	0.517			NA											6	52					0	0	0.00116845	0	0
SPTBN2	6712	broad.mit.edu	37	11	66460088	66460088	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:66460088C>T	uc001ojd.2	-	25	5181	c.5109G>A	c.(5107-5109)CTG>CTA	p.L1703L		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1703	Spectrin 14.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CCAGGTCATCCAGCTCGCGGC	0.677			NA											5	37					0	0	0.000602214	0	0
SHANK2	22941	broad.mit.edu	37	11	70332188	70332188	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:70332188C>A	uc001oqc.2	-	21	4288	c.4210G>T	c.(4210-4212)GAT>TAT	p.D1404Y	SHANK2_uc010rqn.1_Missense_Mutation_p.D816Y|SHANK2_uc001opz.2_Missense_Mutation_p.D809Y|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1025					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AAAATAAAATCCTCATCCAAG	0.552			NA											10	66					1.08611e-07	6.36488e-07	0.000978159	1	0
KIAA1377	57562	broad.mit.edu	37	11	101786027	101786027	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:101786027G>A	uc001pgm.2	+	1	282	c.12G>A	c.(10-12)GGG>GGA	p.G4G	ANGPTL5_uc001pgl.2_Intron	NM_020802	NP_065853	Q9P2H0	K1377_HUMAN	hypothetical protein LOC57562	4							protein binding			breast(2)|ovary(1)|central_nervous_system(1)	4	all_epithelial(12;0.0104)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00931)		BRCA - Breast invasive adenocarcinoma(274;0.038)		TGCTGGCGGGGAGGCCCGGAA	0.701			NA											6	52					0	0	0.00116845	0	0
CCDC77	84318	broad.mit.edu	37	12	541095	541095	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:541095G>C	uc001qig.2	+	8	827	c.647G>C	c.(646-648)AGA>ACA	p.R216T	CCDC77_uc009zdk.2_Missense_Mutation_p.R184T|CCDC77_uc010sdp.1_Missense_Mutation_p.R184T|CCDC77_uc010sdq.1_Missense_Mutation_p.R184T	NM_032358	NP_115734	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77 isoform a	216	Potential.					centrosome				ovary(1)	1	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			CATTACCAAAGAGACATACAG	0.378			NA											8	50					0	0	0.000673444	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:25398284C>T	uc001rgp.1	-	2	216	c.35G>A	c.(34-36)GGT>GAT	p.G12D	KRAS_uc001rgq.1_Missense_Mutation_p.G12D|KRAS_uc001rgr.2_RNA	NM_033360	NP_203524	P01116	RASK_HUMAN	c-K-ras2 protein isoform a precursor	12	GTP.		G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(7175)|p.G12V(4780)|p.G12C(2482)|p.G12A(1180)|p.G12S(1119)|p.G12R(691)|p.G12?(50)|p.G12F(34)|p.G12N(6)|p.G12G(6)|p.G12L(5)|p.G12I(4)|p.G12_G13insG(4)|p.G12E(3)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12fs*3(1)		large_intestine(12391)|pancreas(3285)|lung(2847)|biliary_tract(521)|ovary(443)|endometrium(339)|haematopoietic_and_lymphoid_tissue(318)|stomach(203)|thyroid(149)|prostate(85)|soft_tissue(77)|small_intestine(62)|upper_aerodigestive_tract(59)|cervix(49)|urinary_tract(48)|skin(38)|liver(31)|breast(28)|testis(17)|oesophagus(15)|central_nervous_system(9)|peritoneum(6)|salivary_gland(6)|kidney(5)|gastrointestinal_tract_(site_indeterminate)(5)|thymus(5)|eye(4)|autonomic_ganglia(2)|bone(2)|genital_tract(1)|penis(1)|adrenal_gland(1)	21052	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348	Pancreas(8;6 143 191 305 2070 2426 4376 10944 11745 26467 38091 50869)	G12D(HPAC_PANCREAS)|G12V(SW403_LARGE_INTESTINE)|G12D(HPAFII_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(NCIH441_LUNG)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(PK1_PANCREAS)|G12V(KP3_PANCREAS)|G12D(PANC0813_PANCREAS)|G12A(SW1116_LARGE_INTESTINE)|G12D(LS180_LARGE_INTESTINE)|G12V(NCIH727_LUNG)|G12V(PATU8988S_PANCREAS)|G12V(CAPAN2_PANCREAS)|G12D(KP4_PANCREAS)|G12D(LS513_LARGE_INTESTINE)|G12D(SNUC2A_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(COLO668_LUNG)|G12D(COLO678_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12D(PANC0203_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(SW900_LUNG)|G12V(LCLC97TM1_LUNG)|G12V(SW620_LARGE_INTESTINE)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(SH10TC_STOMACH)|G12V(A498_KIDNEY)|G12D(PK59_PANCREAS)|G12D(HEC1A_ENDOMETRIUM)|G12D(PANC0504_PANCREAS)|G12V(SNGM_ENDOMETRIUM)|G12A(RERFLCAD1_LUNG)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12D(ASPC1_PANCREAS)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12V(RCM1_LARGE_INTESTINE)|G12V(CORL23_LUNG)|G12D(SW1990_PANCREAS)|G12D(HEYA8_OVARY)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12V(HUPT4_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(HEC50B_ENDOMETRIUM)|G12V(YAPC_PANCREAS)|G12V(NCIH2444_LUNG)|G12V(HCC56_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12V(DANG_PANCREAS)|G12V(SHP77_LUNG)|G12D(AGS_STOMACH)|G12D(SKLU1_LUNG)|G12V(QGP1_PANCREAS)|G12D(L33_PANCREAS)|G12V(PANC0327_PANCREAS)|G12D(PANC1_PANCREAS)|G12V(RKN_OVARY)|G12V(PATU8902_PANCREAS)	119	Mis		pancreatic|colorectal|lung|thyroid|AML|others				Cardiofaciocutaneous_syndrome|Noonan_syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	16					0	0	6.4e-05	0	0
ACVRL1	94	broad.mit.edu	37	12	52314550	52314550	+	Nonsense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:52314550C>G	uc001rzj.2	+	10	1668	c.1385C>G	c.(1384-1386)TCA>TGA	p.S462*	ACVRL1_uc001rzk.2_Nonsense_Mutation_p.S462*|ACVRL1_uc010snm.1_Nonsense_Mutation_p.S288*	NM_000020	NP_000011	P37023	ACVL1_HUMAN	activin A receptor type II-like 1 precursor	462	Cytoplasmic (Potential).|Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			lung(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CAGGTCCTCTCAGGCCTAGCT	0.368			NA							Hereditary_Hemorrhagic_Telangiectasia				4	27					0	0	0.000602214	0	0
KRT80	144501	broad.mit.edu	37	12	52565271	52565271	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:52565271G>A	uc001rzx.2	-	9	1368	c.1270C>T	c.(1270-1272)CGA>TGA	p.R424*	KRT80_uc001rzw.2_Nonsense_Mutation_p.R459*|KRT80_uc001rzy.2_3'UTR	NM_182507	NP_872313	Q6KB66	K2C80_HUMAN	keratin 80 isoform a	424	Tail.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.108)		TTCTTCTTTCGGGAGGGGGCC	0.562	GBM(178;2309 2916 15678 35873)		NA											13	72					0	0	0.00136819	0	0
PAN2	9924	broad.mit.edu	37	12	56712094	56712094	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:56712094G>A	uc001skx.2	-	25	3874	c.3501C>T	c.(3499-3501)CTC>CTT	p.L1167L	CNPY2_uc001sku.1_5'Flank|CNPY2_uc001skv.2_5'Flank|PAN2_uc001skw.2_Silent_p.L315L|PAN2_uc001skz.2_Silent_p.L1166L|PAN2_uc001sky.2_Silent_p.L1163L	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1167					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						AAAGACCCTTGAGCACCTTGT	0.512			NA											25	112					0	0	0.000878237	0	0
GEFT	115557	broad.mit.edu	37	12	58009310	58009310	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:58009310C>G	uc001spb.2	+	12	1514	c.1054C>G	c.(1054-1056)CAG>GAG	p.Q352E	GEFT_uc009zpy.2_Missense_Mutation_p.Q391E|GEFT_uc001soz.1_Missense_Mutation_p.Q200E|GEFT_uc001spa.2_Missense_Mutation_p.Q246E|uc001spc.2_RNA|GEFT_uc001spd.2_Missense_Mutation_p.Q57E	NM_182947	NP_891992	Q86VW2	ARHGP_HUMAN	RhoA/RAC/CDC42 exchange factor isoform 1	352	PH.				regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity				0	Melanoma(17;0.122)					ACTGACTGCTCAGGGGAAGCT	0.552			NA											9	58					0	0	0.000274275	0	0
YEATS4	8089	broad.mit.edu	37	12	69783951	69783951	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:69783951G>C	uc001sux.2	+	7	760	c.539G>C	c.(538-540)AGA>ACA	p.R180T		NM_006530	NP_006521	O95619	YETS4_HUMAN	glioma-amplified sequence-41	180	Interaction with MLLT10.|Potential.|Interaction with TACC1.				histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton				0	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			GTGAAAACCAGAGAAAAATTA	0.294			NA											5	28					0	0	0.000602214	0	0
LGR5	8549	broad.mit.edu	37	12	71978333	71978333	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:71978333G>A	uc001swl.2	+	18	2591	c.2543G>A	c.(2542-2544)AGC>AAC	p.S848N	LGR5_uc001swm.2_Missense_Mutation_p.S824N|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	848	Cytoplasmic (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						AAACACCCAAGCTTGATGTCA	0.448			NA											6	102					0	0	0.00116845	0	0
OSBPL8	114882	broad.mit.edu	37	12	76763510	76763510	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:76763510G>C	uc001sye.1	-	20	2627	c.2147C>G	c.(2146-2148)GCT>GGT	p.A716G	OSBPL8_uc001syf.1_Missense_Mutation_p.A674G|OSBPL8_uc001syg.1_Missense_Mutation_p.A674G|OSBPL8_uc001syh.1_Missense_Mutation_p.A691G	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	716					lipid transport		lipid binding			ovary(1)	1						ATCCCTGGCAGCTTGTCTTTG	0.413			NA											7	52					0	0	0.000157383	0	0
USP44	84101	broad.mit.edu	37	12	95912001	95912001	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:95912001G>C	uc001teg.2	-	6	2212	c.2068C>G	c.(2068-2070)CCA>GCA	p.P690A	USP44_uc001teh.2_Missense_Mutation_p.P690A|USP44_uc009zte.2_Missense_Mutation_p.P687A	NM_001042403	NP_001035862	Q9H0E7	UBP44_HUMAN	ubiquitin thiolesterase 44	690					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)|breast(1)|central_nervous_system(1)	3						AGGAGCTCTGGAGGCAAAAGT	0.433			NA											5	69					0	0	0.00116845	0	0
POLR3B	55703	broad.mit.edu	37	12	106853102	106853102	+	Silent	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:106853102A>T	uc001tlp.2	+	22	2748	c.2526A>T	c.(2524-2526)GGA>GGT	p.G842G	POLR3B_uc001tlq.2_Silent_p.G784G	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	842					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CTTTGGAAGGAAGTAATGTAC	0.378			NA											7	59					0	0	8.12818e-05	0	0
CUX2	23316	broad.mit.edu	37	12	111742083	111742083	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:111742083C>A	uc001tsa.1	+	10	976	c.823C>A	c.(823-825)CGC>AGC	p.R275S		NM_015267	NP_056082	O14529	CUX2_HUMAN	cut-like 2	275	Potential.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)|breast(1)	6						CAGCTCCATCCGCCTGGCTTG	0.642			NA											8	21					7.48243e-07	4.2912e-06	0.000442599	1	0
DNAH10	196385	broad.mit.edu	37	12	124274575	124274575	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr12:124274575C>T	uc001uft.3	+	11	1564	c.1539C>T	c.(1537-1539)GTC>GTT	p.V513V	DNAH10_uc010tav.1_5'UTR|DNAH10_uc010taw.1_5'UTR	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	513	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACGGCCTAGTCACCCCCATGG	0.468			NA											19	152					0	0	0.00188189	0	0
MYO16	23026	broad.mit.edu	37	13	109540774	109540774	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr13:109540774C>T	uc001vqt.1	+	14	1668	c.1542C>T	c.(1540-1542)CTC>CTT	p.L514L	MYO16_uc010agk.1_Silent_p.L536L|MYO16_uc001vqu.1_Silent_p.L314L|MYO16_uc010tjh.1_Silent_p.L26L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	514	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TAAGACACCTCACCTGCAGGG	0.443			NA											7	70					0	0	0.000442599	0	0
AKAP6	9472	broad.mit.edu	37	14	33014499	33014499	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr14:33014499A>G	uc001wrq.2	+	4	810	c.640A>G	c.(640-642)AAT>GAT	p.N214D	AKAP6_uc010aml.2_Missense_Mutation_p.N211D	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	214					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATGTTCTCAAAATTACTTGTC	0.438	Melanoma(49;821 1200 7288 13647 42351)		NA											13	168					0	0	0.00136819	0	0
PPM1A	5494	broad.mit.edu	37	14	60749757	60749757	+	Missense_Mutation	SNP	G	G	A	rs143557303		TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr14:60749757G>A	uc010apn.2	+	3	738	c.336G>A	c.(334-336)ATG>ATA	p.M112I	PPM1A_uc001xew.3_Missense_Mutation_p.M185I|PPM1A_uc001xex.3_Missense_Mutation_p.M112I|PPM1A_uc001xey.3_Missense_Mutation_p.M112I	NM_021003	NP_066283	P35813	PPM1A_HUMAN	protein phosphatase 1A isoform 1	112					cell cycle arrest|insulin receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein dephosphorylation|Wnt receptor signaling pathway	cytosol|nucleus|protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein serine/threonine phosphatase activity|signal transducer activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.046)		ATGAACACATGAGAGTTATGT	0.403			NA											11	56					0	0	0.000978159	0	0
SYNE2	23224	broad.mit.edu	37	14	64469512	64469512	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr14:64469512G>A	uc001xgm.2	+	30	4091	c.3861G>A	c.(3859-3861)AAG>AAA	p.K1287K	SYNE2_uc001xgl.2_Silent_p.K1287K	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1287	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TTGTATTAAAGGAGTTACACC	0.343			NA											8	63					0	0	0.000274275	0	0
SNW1	22938	broad.mit.edu	37	14	78189587	78189587	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr14:78189587C>A	uc001xuf.2	-	11	1094	c.1067G>T	c.(1066-1068)CGG>CTG	p.R356L	SNW1_uc010tvm.1_Missense_Mutation_p.R281L|SNW1_uc010asu.2_Missense_Mutation_p.R194L|SNW1_uc010tvn.1_Missense_Mutation_p.R356L	NM_012245	NP_036377	Q13573	SNW1_HUMAN	SKI-interacting protein	356					negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			ovary(1)	1			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CCTGTCATGCCGGATTTCATC	0.443			NA											32	88					8.73648e-17	5.66394e-16	0.000814825	1	0
AHNAK2	113146	broad.mit.edu	37	14	105418167	105418167	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr14:105418167C>G	uc010axc.1	-	7	3741	c.3621G>C	c.(3619-3621)AAG>AAC	p.K1207N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K1107N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1207						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGTCAGTGGTCTTGAGGTCCC	0.662			NA											20	161					0	0	0.000295444	0	0
UBE3A	7337	broad.mit.edu	37	15	25599501	25599501	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr15:25599501T>A	uc001zaq.2	-	9	2362	c.2362A>T	c.(2362-2364)AGG>TGG	p.R788W	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.R765W|UBE3A_uc001zas.2_Missense_Mutation_p.R785W|UBE3A_uc001zat.2_Missense_Mutation_p.R765W	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	788	HECT.				brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GTACCTCACCTAATCAGAACA	0.383			NA											5	29					0	0	0.00116845	0	0
SPRED1	161742	broad.mit.edu	37	15	38643583	38643583	+	Missense_Mutation	SNP	A	A	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr15:38643583A>C	uc001zka.3	+	7	1388	c.1053A>C	c.(1051-1053)AAA>AAC	p.K351N		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	351	SPR.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TTAGGGGAAAATGTCAGGATG	0.393	Melanoma(196;2146 2959 7698 16532)		NA							Legius_syndrome				8	80					0	0	0.000274275	0	0
LCMT2	9836	broad.mit.edu	37	15	43621554	43621554	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr15:43621554C>A	uc001zrg.2	-	1	1338	c.1134G>T	c.(1132-1134)GAG>GAT	p.E378D	LCMT2_uc010udn.1_5'UTR|ADAL_uc001zrh.2_5'Flank|ADAL_uc010udo.1_5'Flank	NM_014793	NP_055608	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	378					tRNA processing		methyltransferase activity|protein binding				0		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	GCCCCTCCTGCTCTCCAAATC	0.542			NA											19	40					6.94344e-10	4.35425e-09	0.00074312	1	0
FAM63B	54629	broad.mit.edu	37	15	59144100	59144100	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr15:59144100C>G	uc002afj.2	+	8	1875	c.1673C>G	c.(1672-1674)TCT>TGT	p.S558C	FAM63B_uc002afi.2_Missense_Mutation_p.S558C|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	558	Gln-rich.									central_nervous_system(1)	1						AGACGGGCTTCTCAATACTAT	0.453			NA											11	54					0	0	0.000978159	0	0
LRRC49	54839	broad.mit.edu	37	15	71256259	71256259	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr15:71256259G>T	uc002asw.2	+	9	1156	c.909G>T	c.(907-909)ATG>ATT	p.M303I	LRRC49_uc002asu.2_Missense_Mutation_p.M293I|LRRC49_uc002asx.2_Missense_Mutation_p.M259I|LRRC49_uc010ukf.1_Missense_Mutation_p.M308I|LRRC49_uc002asy.2_Missense_Mutation_p.M9I|LRRC49_uc002asz.2_Missense_Mutation_p.M275I	NM_017691	NP_060161	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	303	Potential.|LRRCT.					cytoplasm|microtubule				ovary(1)	1						AGCTAGATATGAAGAGAATCA	0.448			NA											8	63					5.18039e-06	2.9458e-05	0.000157383	1	0
A2BP1	54715	broad.mit.edu	37	16	7645644	7645645	+	Splice_Site	DNP	GT	GT	TC			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr16:7645644_7645645GT>TC	uc002cys.2	+	8	1549	c.561_splice	c.e8+1	p.E187_splice	A2BP1_uc010buf.1_Splice_Site_p.E187_splice|A2BP1_uc002cyr.1_Splice_Site_p.E186_splice|A2BP1_uc002cyt.2_Splice_Site_p.E187_splice|A2BP1_uc010uxz.1_Splice_Site_p.E230_splice|A2BP1_uc010uya.1_Intron|A2BP1_uc002cyv.1_Splice_Site_p.E187_splice|A2BP1_uc010uyb.1_Splice_Site_p.E187_splice|A2BP1_uc002cyw.2_Splice_Site_p.E207_splice|A2BP1_uc002cyy.2_Splice_Site_p.E207_splice|A2BP1_uc002cyx.2_Splice_Site_p.E207_splice|A2BP1_uc010uyc.1_Splice_Site_p.E207_splice	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4						mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		TAAAATCGAGGTGCATGTTCAA	0.446			NA											7	106					0	0	6.4e-05	0	0
ACSM2A	123876	broad.mit.edu	37	16	20494500	20494500	+	Splice_Site	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr16:20494500G>T	uc010bwe.2	+	14	1868	c.1629_splice	c.e14+1	p.K543_splice	ACSM2A_uc002dhf.3_Splice_Site_p.K543_splice|ACSM2A_uc002dhg.3_Splice_Site_p.K543_splice|ACSM2A_uc010vay.1_Splice_Site_p.K464_splice|ACSM2A_uc002dhh.3_Splice_Site_p.K173_splice	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member						fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						CCCAAGAAAGGTAAGGCCTTT	0.463			NA											21	116					2.98393e-07	1.73352e-06	0.000375601	1	0
ITGAL	3683	broad.mit.edu	37	16	30490755	30490755	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr16:30490755G>A	uc002dyi.3	+	6	725	c.549G>A	c.(547-549)ATG>ATA	p.M183I	ITGAL_uc010veu.1_Intron|ITGAL_uc002dyj.3_Intron|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	183	VWFA.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	AGGATGTGATGAAGAAACTCA	0.284	NSCLC(110;1462 1641 3311 33990 49495)		NA											5	36					0	0	0.00116845	0	0
ARMC5	79798	broad.mit.edu	37	16	31477721	31477721	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr16:31477721C>G	uc002ecc.2	+	6	2848	c.2319C>G	c.(2317-2319)TTC>TTG	p.F773L	ARMC5_uc010vfn.1_Missense_Mutation_p.F868L|ARMC5_uc010vfo.1_Missense_Mutation_p.F805L|ARMC5_uc002eca.3_3'UTR|ARMC5_uc010vfp.1_Missense_Mutation_p.F581L|ARMC5_uc002ecb.2_3'UTR	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	773	BTB.						binding			pancreas(1)	1						CCTCCCCTTTCTTCCGGGCCC	0.677			NA											3	19					0	0	6.4e-05	0	0
ZNF423	23090	broad.mit.edu	37	16	49671869	49671869	+	Silent	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr16:49671869C>A	uc002efs.2	-	5	1492	c.1194G>T	c.(1192-1194)CGG>CGT	p.R398R	ZNF423_uc010vgn.1_Silent_p.R281R	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	398					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GCCCGTCATCCCGCATCTTCT	0.632			NA											7	42					8.12818e-05	0.00044889	8.12818e-05	1	0
CIAPIN1	57019	broad.mit.edu	37	16	57473209	57473209	+	Silent	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr16:57473209T>A	uc002ell.1	-	3	366	c.195A>T	c.(193-195)TCA>TCT	p.S65S	CIAPIN1_uc002elk.1_RNA|CIAPIN1_uc002elm.1_Splice_Site_p.C53_splice|CIAPIN1_uc002eln.1_Silent_p.S65S|CIAPIN1_uc010cda.1_Silent_p.S65S|CIAPIN1_uc002elo.1_Silent_p.S65S|CIAPIN1_uc010vhm.1_Silent_p.S65S	NM_020313	NP_064709	Q6FI81	CPIN1_HUMAN	cytokine induced apoptosis inhibitor 1	65					anti-apoptosis|apoptosis	cytoplasm|nucleolus					0						GGACTAAACCTGACAAAATAA	0.493			NA											54	120					0	0	0.000781405	0	0
GGT6	124975	broad.mit.edu	37	17	4463036	4463036	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:4463036G>A	uc002fyd.3	-	2	220	c.160C>T	c.(160-162)CCC>TCC	p.P54S	GGT6_uc010vsb.1_5'UTR|GGT6_uc002fyc.3_Missense_Mutation_p.P54S|GGT6_uc010vsc.1_Missense_Mutation_p.P54S	NM_001122890	NP_001116362	Q6P531	GGT6_HUMAN	gamma-glutamyltransferase 6 isoform a	54	Cytoplasmic (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			skin(1)	1						CAGGTTCCGGGCAGCCCGCCA	0.657			NA											7	17					0	0	8.12818e-05	0	0
MYH2	4620	broad.mit.edu	37	17	10429036	10429036	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:10429036C>T	uc010coi.2	-	31	4473	c.4345G>A	c.(4345-4347)GAC>AAC	p.D1449N	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.D1449N|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1449	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TGCTTTTTGTCAAGGGCGGCA	0.483			NA											13	77					0	0	0.000219431	0	0
DNAH9	1770	broad.mit.edu	37	17	11631181	11631181	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:11631181G>T	uc002gne.2	+	28	5824	c.5756G>T	c.(5755-5757)GGC>GTC	p.G1919V	DNAH9_uc010coo.2_Missense_Mutation_p.G1213V	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1919	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGTGCCTGGGGCTGCTTTGAT	0.483			NA											8	42					1.33987e-11	8.48163e-11	0.000673444	1	0
SLC47A1	55244	broad.mit.edu	37	17	19470429	19470429	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:19470429G>A	uc002gvy.1	+	14	1283	c.1197G>A	c.(1195-1197)CTG>CTA	p.L399L	SLC47A1_uc002gvx.2_Silent_p.L399L|SLC47A1_uc010vyz.1_Silent_p.L376L|SLC47A1_uc010cqp.1_Intron|SLC47A1_uc010cqq.1_Silent_p.L204L|SLC47A1_uc010vza.1_Silent_p.L111L|SLC47A1_uc010vzb.1_Silent_p.L133L|SLC47A1_uc010vzc.1_Silent_p.L71L	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	399	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GTGGTGTTCTGAGGGGGAGTG	0.532			NA											25	169					0	0	0.000586117	0	0
MAP2K3	5606	broad.mit.edu	37	17	21206516	21206516	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:21206516C>G	uc002gys.2	+	7	803	c.538C>G	c.(538-540)CTG>GTG	p.L180V	MAP2K3_uc002gyt.2_Missense_Mutation_p.L151V|MAP2K3_uc002gyu.2_Missense_Mutation_p.L151V	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	180	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		CCTGGAGCATCTGCACAGCAA	0.627			NA											3	18					0	0	0.000602214	0	0
GGNBP2	79893	broad.mit.edu	37	17	34923616	34923616	+	Splice_Site	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:34923616G>A	uc002hnb.2	+	6	890	c.641_splice	c.e6+1	p.R214_splice	GGNBP2_uc002hna.2_Splice_Site_p.R214_splice	NM_024835	NP_079111	Q9H3C7	GGNB2_HUMAN	zinc finger protein 403						cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				ovary(2)	2		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		GAAAACACAGGTAAGTCTGAT	0.408			NA											5	23					0	0	0.000602214	0	0
OR4D2	124538	broad.mit.edu	37	17	56247649	56247649	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:56247649C>G	uc010wnp.1	+	1	633	c.633C>G	c.(631-633)TTC>TTG	p.F211L		NM_001004707	NP_001004707	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D,	211	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						TCGTCTGGTTCTTCCTCCTCC	0.537			NA											26	68					0	0	0.00106085	0	0
RGS9	8787	broad.mit.edu	37	17	63186341	63186341	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr17:63186341G>C	uc002jfe.2	+	11	843	c.733G>C	c.(733-735)GTG>CTG	p.V245L	RGS9_uc010dem.2_Missense_Mutation_p.V242L|RGS9_uc002jfd.2_Missense_Mutation_p.V242L|RGS9_uc002jff.2_RNA|RGS9_uc002jfg.2_Missense_Mutation_p.V16L	NM_003835	NP_003826	O75916	RGS9_HUMAN	regulator of G-protein signaling 9 isoform 1	245	G protein gamma.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			ovary(2)|skin(2)	4						GAAGTCTTCTGTGTCCCTGGG	0.478			NA											121	222					0	0	0.000781405	0	0
ASXL3	80816	broad.mit.edu	37	18	31318481	31318481	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr18:31318481G>A	uc010dmg.1	+	11	1168	c.1113G>A	c.(1111-1113)AAG>AAA	p.K371K	ASXL3_uc002kxq.2_Silent_p.K78K	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AATCTGTGAAGCTCACTACTG	0.448			NA											12	26					0	0	0.00136819	0	0
RTTN	25914	broad.mit.edu	37	18	67687924	67687924	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr18:67687924G>A	uc002lkp.2	-	45	6148	c.6080C>T	c.(6079-6081)ACG>ATG	p.T2027M	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Missense_Mutation_p.T1115M|RTTN_uc002lkn.2_Missense_Mutation_p.T17M|RTTN_uc010dqp.2_Missense_Mutation_p.T279M	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	2027							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				CTGCTGAACCGTGGTGTTCTC	0.473			NA											12	111					0	0	0.00185496	0	0
MED16	10025	broad.mit.edu	37	19	873486	873486	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:873486T>A	uc002lqd.1	-	11	2019	c.1868A>T	c.(1867-1869)GAC>GTC	p.D623V	MED16_uc010drw.1_Missense_Mutation_p.D448V|MED16_uc002lqe.2_Missense_Mutation_p.D612V|MED16_uc002lqf.2_Missense_Mutation_p.D612V|MED16_uc010xfv.1_RNA|MED16_uc010xfw.1_Missense_Mutation_p.D543V|MED16_uc010xfx.1_Missense_Mutation_p.D468V|MED16_uc010xfy.1_Missense_Mutation_p.D200V	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	623					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCACGAAGTCGCCCACCCA	0.612			NA											19	38					0	0	0.00152264	0	0
SBNO2	22904	broad.mit.edu	37	19	1113547	1113547	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:1113547T>A	uc002lrk.3	-	19	2472	c.2234A>T	c.(2233-2235)CAG>CTG	p.Q745L	SBNO2_uc002lrj.3_Missense_Mutation_p.Q688L|SBNO2_uc010dse.2_Missense_Mutation_p.Q728L|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1	745					macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCACCCGCTGGGGGCCGCC	0.697			NA											5	10					0	0	0.00116845	0	0
C19orf35	374872	broad.mit.edu	37	19	2276204	2276204	+	Silent	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:2276204G>C	uc002lvn.2	-	4	997	c.897C>G	c.(895-897)GGC>GGG	p.G299G	SPPL2B_uc010dsw.1_Intron	NM_198532	NP_940934	Q6ZS72	CS035_HUMAN	hypothetical protein LOC374872	299										pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTAGGGCCGCGCCCCACGCCT	0.711			NA											2	1					0	0	6.4e-05	0	0
HDGFRP2	84717	broad.mit.edu	37	19	4499589	4499589	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:4499589G>A	uc002mao.2	+	14	1770	c.1677G>A	c.(1675-1677)CAG>CAA	p.Q559Q	HDGFRP2_uc002map.2_Silent_p.Q559Q|HDGFRP2_uc010dtz.1_RNA|HDGFRP2_uc010dua.2_Silent_p.Q24Q|HDGFRP2_uc002maq.1_Silent_p.Q24Q	NM_001001520	NP_001001520	Q7Z4V5	HDGR2_HUMAN	hepatoma-derived growth factor-related protein 2	559	Potential.				transcription, DNA-dependent	nucleus	DNA binding|protein binding				0						aggcggtgcagaaagtgaaca	0.244			NA											4	16					0	0	0.00024832	0	0
DCAF15	90379	broad.mit.edu	37	19	14065430	14065430	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:14065430A>G	uc002mxt.2	+	3	329	c.323A>G	c.(322-324)CAT>CGT	p.H108R	PODNL1_uc010xnj.1_5'Flank|PODNL1_uc002mxs.2_5'Flank	NM_138353	NP_612362	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	108										central_nervous_system(1)	1						TACATCTACCATCTGTACTGG	0.493			NA											9	57					0	0	0.000673444	0	0
CHERP	10523	broad.mit.edu	37	19	16633869	16633869	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:16633869G>A	uc002nei.1	-	11	2048	c.1974C>T	c.(1972-1974)CTC>CTT	p.L658L	MED26_uc002nee.2_Intron|CHERP_uc010xpg.1_Silent_p.L197L	NM_006387	NP_006378	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum	658	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			ovary(2)	2						TTACCTTCACGAGGGGGGCCA	0.607			NA											7	54					0	0	0.000157383	0	0
ZNF676	163223	broad.mit.edu	37	19	22363504	22363504	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:22363504A>T	uc002nqs.1	-	3	1333	c.1015T>A	c.(1015-1017)TGT>AGT	p.C339S		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	339	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CATTCTTCACATTTGTAGGGT	0.413			NA											20	66					0	0	0.00152264	0	0
ZFP82	284406	broad.mit.edu	37	19	36883908	36883908	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:36883908A>G	uc002ody.1	-	5	1569	c.1334T>C	c.(1333-1335)ATT>ACT	p.I445T		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						TTTCTCACCAATATGAATACT	0.408			NA											9	72					0	0	0.000442599	0	0
FCGBP	8857	broad.mit.edu	37	19	40366480	40366480	+	Nonsense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:40366480G>C	uc002omp.3	-	30	13762	c.13754C>G	c.(13753-13755)TCA>TGA	p.S4585*		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4585	VWFD 11.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CGAGAGCCCTGAGGTTGTGGT	0.672			NA											7	65					0	0	0.000157383	0	0
CYP2A13	1553	broad.mit.edu	37	19	41594951	41594951	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:41594951G>A	uc002opt.2	+	2	307	c.298G>A	c.(298-300)GGG>AGG	p.G100R		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	100					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GGAGTTCAGCGGGCGAGGCGA	0.642			NA											9	43					0	0	0.000274275	0	0
PSG5	5673	broad.mit.edu	37	19	43679469	43679469	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:43679469T>C	uc002ovu.2	-	4	993	c.862A>G	c.(862-864)ATC>GTC	p.I288V	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.I163V|PSG5_uc002ovx.2_Missense_Mutation_p.I288V|PSG5_uc002ovv.2_Missense_Mutation_p.I381V|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	288	Ig-like C2-type 2.			I -> M (in Ref. 3; AAA36514).	female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				ATTTGGGGGATAGAGAGCTTT	0.448			NA											29	369					0	0	0.00127121	0	0
PSG5	5673	broad.mit.edu	37	19	43679557	43679557	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:43679557G>A	uc002ovu.2	-	4	905	c.774C>T	c.(772-774)TAC>TAT	p.Y258Y	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Silent_p.Y133Y|PSG5_uc002ovx.2_Silent_p.Y258Y|PSG5_uc002ovv.2_Silent_p.Y351Y|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	258	Ig-like C2-type 2.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				AGCAGGACAAGTAGAGGTTTT	0.458			NA											58	316					0	0	0.000781405	0	0
SLC17A7	57030	broad.mit.edu	37	19	49934332	49934332	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:49934332G>A	uc002pnp.2	-	11	1501	c.1329C>T	c.(1327-1329)GGC>GGT	p.G443G	SLC17A7_uc002pno.2_Silent_p.G105G	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	443	Helical; (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		GTGTGCCCACGCCGTTGGAGA	0.622			NA											6	29					0	0	8.12818e-05	0	0
ZNF761	388561	broad.mit.edu	37	19	53952852	53952852	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:53952852G>T	uc010eqp.2	+	5	561	c.103G>T	c.(103-105)GAC>TAC	p.D35Y	ZNF761_uc002qbr.2_RNA|ZNF761_uc010ydy.1_5'UTR|ZNF761_uc002qbs.2_RNA|ZNF761_uc002qbt.1_5'Flank	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	35	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TCTATACAGGGACGTGATGCT	0.468			NA											10	39					7.03913e-09	4.27444e-08	0.00136819	1	0
ZNF761	388561	broad.mit.edu	37	19	53959377	53959377	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:53959377G>C	uc010eqp.2	+	7	2074	c.1616G>C	c.(1615-1617)TGC>TCC	p.C539S	ZNF761_uc010ydy.1_Missense_Mutation_p.C485S|ZNF761_uc002qbt.1_Missense_Mutation_p.C485S	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	539	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		TCCCTTACCTGCCATCGTAGA	0.438			NA											20	95					0	0	0.00121646	0	0
LILRB2	10288	broad.mit.edu	37	19	54778622	54778622	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:54778622C>T	uc002qfb.2	-	14	1978	c.1712G>A	c.(1711-1713)AGA>AAA	p.R571K	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_3'UTR|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.R570K|LILRB2_uc010yet.1_Missense_Mutation_p.R455K	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	571	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGCCTTCCGTCTGAGGGTCAA	0.632			NA											9	83					0	0	0.000274275	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55605745	55605745	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:55605745G>A	uc002qix.2	-	13	1667	c.1651C>T	c.(1651-1653)CGT>TGT	p.R551C	PPP1R12C_uc010yfs.1_Missense_Mutation_p.R477C|PPP1R12C_uc002qiy.2_Missense_Mutation_p.R550C	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	551						cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CGCATGAGACGGGAGCGAGCT	0.438			NA											9	71					0	0	0.000442599	0	0
ZNF132	7691	broad.mit.edu	37	19	58945293	58945293	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr19:58945293C>G	uc002qst.3	-	3	1919	c.1518G>C	c.(1516-1518)CAG>CAC	p.Q506H		NM_003433	NP_003424	P52740	ZN132_HUMAN	zinc finger protein 132	506	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0171)|Lung(386;0.182)		TATGTACTTTCTGGTGCTGGA	0.488			NA											9	51					0	0	0.000442599	0	0
RNASEH1	246243	broad.mit.edu	37	2	3596229	3596229	+	Splice_Site	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:3596229C>G	uc002qxt.2	-	6	739	c.649_splice	c.e6+1	p.G217_splice	RNASEH1_uc002qxs.2_Splice_Site_p.G100_splice	NM_002936	NP_002927	O60930	RNH1_HUMAN	ribonuclease H1						RNA catabolic process	cytoplasm	magnesium ion binding|ribonuclease H activity|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0713)|Epithelial(75;0.167)|all cancers(51;0.22)		TGAAAGCTTACCATTTATCGT	0.413			NA											3	38					0	0	0.00024832	0	0
OSR1	130497	broad.mit.edu	37	2	19553422	19553422	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:19553422C>A	uc002rdc.2	-	2	448	c.145G>T	c.(145-147)GCT>TCT	p.A49S		NM_145260	NP_660303	Q8TAX0	OSR1_HUMAN	odd-skipped related 1	49					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				AGGTGCACAGCGTGCAACGCG	0.612			NA											5	19					1.23904e-05	6.98652e-05	0.000602214	1	0
CAPN13	92291	broad.mit.edu	37	2	30985980	30985980	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:30985980G>A	uc002rnn.2	-	7	918	c.742C>T	c.(742-744)CTC>TTC	p.L248F	CAPN13_uc002rnp.1_Missense_Mutation_p.L248F	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	248	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TAGGCATGGAGACTCACCAGC	0.522			NA											5	19					0	0	0.00116845	0	0
SPAST	6683	broad.mit.edu	37	2	32339713	32339713	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:32339713G>C	uc002roc.2	+	5	910	c.689G>C	c.(688-690)GGA>GCA	p.G230A	SPAST_uc002rod.2_Missense_Mutation_p.G198A	NM_014946	NP_055761	Q9UBP0	SPAST_HUMAN	spastin isoform 1	230	Required for interaction with RTN1.|Sufficient for microtubule severing.|Sufficient for interaction with microtubules.				cell cycle|cell death|cell differentiation|cytokinesis, completion of separation|ER to Golgi vesicle-mediated transport|microtubule bundle formation|microtubule severing|nervous system development|protein hexamerization|protein homooligomerization	endoplasmic reticulum|endosome|integral to membrane|microtubule|microtubule organizing center|nucleus|perinuclear region of cytoplasm|spindle	alpha-tubulin binding|ATP binding|beta-tubulin binding|microtubule binding|microtubule-severing ATPase activity			breast(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					TCAGAAAGTGGAGCTGTTCCA	0.358			NA											6	44					0	0	0.00116845	0	0
THADA	63892	broad.mit.edu	37	2	43797537	43797537	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:43797537T>C	uc002rsw.3	-	14	2529	c.2177A>G	c.(2176-2178)CAG>CGG	p.Q726R	THADA_uc010far.2_5'UTR|THADA_uc002rsx.3_Missense_Mutation_p.Q726R|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.Q436R|THADA_uc010fat.1_5'UTR|THADA_uc002rta.2_Missense_Mutation_p.Q436R|THADA_uc002rtb.1_Missense_Mutation_p.Q726R|THADA_uc002rtc.3_Missense_Mutation_p.Q726R|THADA_uc002rtd.2_Missense_Mutation_p.Q726R	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	726							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				CTTATACTGCTGTAAAGAAAC	0.313			NA											6	44					0	0	0.000274275	0	0
CYP26B1	56603	broad.mit.edu	37	2	72360361	72360361	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:72360361G>A	uc002sih.1	-	5	937	c.937C>T	c.(937-939)CTG>TTG	p.L313L	CYP26B1_uc010yra.1_Silent_p.L296L|CYP26B1_uc010yrb.1_Silent_p.L238L	NM_019885	NP_063938	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily b,	313					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			skin(2)	2						GGGTGCTTCAGCAGCTGCATG	0.652			NA											4	20					0	0	0.00024832	0	0
ALMS1	7840	broad.mit.edu	37	2	73830384	73830384	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:73830384G>A	uc002sje.1	+	23	12429	c.12318G>A	c.(12316-12318)CAG>CAA	p.Q4106Q	ALMS1_uc002sjf.1_Silent_p.Q4062Q|ALMS1_uc002sjh.1_Silent_p.Q3492Q	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	4104					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TGGCTATCCAGAAGAACAAGC	0.478			NA											7	36					0	0	0.000274275	0	0
DCTN1	1639	broad.mit.edu	37	2	74604792	74604792	+	Nonsense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:74604792G>C	uc002skx.2	-	3	652	c.341C>G	c.(340-342)TCA>TGA	p.S114*	DCTN1_uc002skv.2_5'Flank|DCTN1_uc002sku.2_5'Flank|DCTN1_uc002skw.1_Nonsense_Mutation_p.S97*|DCTN1_uc010ffd.2_Nonsense_Mutation_p.S114*|DCTN1_uc002sky.2_Nonsense_Mutation_p.S97*	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	114					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						GAGGACTTTTGAAGCAGAAGA	0.468			NA											9	90					0	0	0.000673444	0	0
REG3G	130120	broad.mit.edu	37	2	79254244	79254244	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:79254244A>T	uc002snw.2	+	4	365	c.280A>T	c.(280-282)AGC>TGC	p.S94C	REG3G_uc002snx.2_Missense_Mutation_p.S94C|REG3G_uc010ffu.2_Intron	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	94	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						CCTGGTGAGGAGCATTAGTAA	0.537			NA											18	96					0	0	0.00152264	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125405345	125405345	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:125405345C>G	uc002tno.2	+	13	2248	c.1884C>G	c.(1882-1884)ATC>ATG	p.I628M	CNTNAP5_uc010flu.2_Missense_Mutation_p.I629M	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	628	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		AGGACAAGATCTGGACATCAG	0.547			NA											4	22					0	0	0.00024832	0	0
LRP1B	53353	broad.mit.edu	37	2	141641532	141641532	+	Silent	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:141641532T>A	uc002tvj.1	-	25	4995	c.4023A>T	c.(4021-4023)ACA>ACT	p.T1341T	LRP1B_uc010fnl.1_Silent_p.T523T	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1341	Extracellular (Potential).|LDL-receptor class B 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCAGTCGACTGTCAGGCCTT	0.473	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			14	106					0	0	0.000308642	0	0
LRP1B	53353	broad.mit.edu	37	2	141773358	141773358	+	Silent	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:141773358A>G	uc002tvj.1	-	13	3069	c.2097T>C	c.(2095-2097)GGT>GGC	p.G699G	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	699	Extracellular (Potential).|LDL-receptor class B 7.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCAGAGTTAAACCGTTTGGCC	0.408	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			9	39					0	0	0.000274275	0	0
FIGN	55137	broad.mit.edu	37	2	164466757	164466757	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:164466757C>A	uc002uck.1	-	3	1896	c.1585G>T	c.(1585-1587)GGG>TGG	p.G529W		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	529	ATP (By similarity).					nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						TTGCCTGTCCCCCGAGGTCCA	0.512			NA											11	40					0.000978159	0.00527184	0.000978159	1	0
FIGN	55137	broad.mit.edu	37	2	164467138	164467138	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:164467138G>A	uc002uck.1	-	3	1515	c.1204C>T	c.(1204-1206)CCT>TCT	p.P402S		NM_018086	NP_060556	Q5HY92	FIGN_HUMAN	fidgetin	402						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			large_intestine(2)|ovary(1)|skin(1)	4						CTGTAGGAAGGAGGGGTCAGA	0.473			NA											14	69					0	0	0.000219431	0	0
XIRP2	129446	broad.mit.edu	37	2	167760039	167760039	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:167760039G>T	uc002udx.2	+	1	65	c.47G>T	c.(46-48)TGG>TTG	p.W16L	XIRP2_uc010fpn.2_Missense_Mutation_p.W16L|XIRP2_uc010fpo.2_Missense_Mutation_p.W16L|XIRP2_uc010fpp.2_Missense_Mutation_p.W16L	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	Error:Variant_position_missing_in_A4UGR9_after_alignment					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGGCAGAAATGGGAATCTTGT	0.473			NA											5	49					0.000602214	0.00325876	0.000602214	1	0
TTN	7273	broad.mit.edu	37	2	179431323	179431323	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:179431323G>C	uc010zfg.1	-	275	72056	c.71832C>G	c.(71830-71832)ATC>ATG	p.I23944M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I17639M|TTN_uc010zfi.1_Missense_Mutation_p.I17572M|TTN_uc010zfj.1_Missense_Mutation_p.I17447M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24871							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCCATCATAGATGGGTTTAC	0.443			NA											29	220					0	0	0.00127121	0	0
TTN	7273	broad.mit.edu	37	2	179439646	179439646	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:179439646T>A	uc010zfg.1	-	275	63733	c.63509A>T	c.(63508-63510)GAA>GTA	p.E21170V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E14865V|TTN_uc010zfi.1_Missense_Mutation_p.E14798V|TTN_uc010zfj.1_Missense_Mutation_p.E14673V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	22097							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGATGAAACTTCATCAAATTT	0.448			NA											5	19					0	0	0.00116845	0	0
SSFA2	6744	broad.mit.edu	37	2	182767109	182767109	+	Silent	SNP	T	T	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:182767109T>C	uc002uoi.2	+	8	1651	c.1329T>C	c.(1327-1329)CCT>CCC	p.P443P	SSFA2_uc002uoh.2_Silent_p.P443P|SSFA2_uc002uoj.2_Silent_p.P443P|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Silent_p.P290P|SSFA2_uc002uol.2_Silent_p.P290P	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	443						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			TATCCACACCTGAAAAAGAGC	0.393			NA											4	50					0	0	0.000602214	0	0
COL5A2	1290	broad.mit.edu	37	2	189929354	189929354	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:189929354C>A	uc002uqk.2	-	25	1920	c.1645G>T	c.(1645-1647)GGT>TGT	p.G549C	COL5A2_uc010frx.2_Missense_Mutation_p.G125C	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	549					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCTGAAGAACCTACAGGACCC	0.488			NA											19	51					3.5997e-14	2.31139e-13	0.000295444	1	0
ALS2	57679	broad.mit.edu	37	2	202626448	202626448	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr2:202626448C>T	uc002uyo.2	-	4	625	c.269G>A	c.(268-270)GGG>GAG	p.G90E	ALS2_uc002uyp.3_Missense_Mutation_p.G90E|ALS2_uc002uyq.2_Missense_Mutation_p.G90E|ALS2_uc002uyr.2_Missense_Mutation_p.G90E	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	90	RCC1 1.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						AACATATTGCCCAACCAGGGC	0.502			NA											17	84					0	0	0.00121646	0	0
PLCB4	5332	broad.mit.edu	37	20	9376236	9376236	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr20:9376236A>G	uc002wnf.2	+	18	1617	c.1481A>G	c.(1480-1482)GAG>GGG	p.E494G	PLCB4_uc010gbw.1_Missense_Mutation_p.E494G|PLCB4_uc010gbx.2_Missense_Mutation_p.E494G|PLCB4_uc002wne.2_Missense_Mutation_p.E494G|PLCB4_uc002wnh.2_Missense_Mutation_p.E341G	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	494					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						AACATCTTAGAGGACGATAAT	0.378			NA											9	63					0	0	0.000673444	0	0
KIF16B	55614	broad.mit.edu	37	20	16493527	16493527	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr20:16493527G>A	uc002wpg.1	-	5	548	c.390C>T	c.(388-390)TTC>TTT	p.F130F	KIF16B_uc010gch.1_Silent_p.F130F|KIF16B_uc010gci.1_Silent_p.F130F|KIF16B_uc010gcj.1_Silent_p.F130F	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	130	Kinesin-motor.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						TTATCCGACTGAAGAGTCCTT	0.463			NA											6	50					0	0	8.12818e-05	0	0
CHD6	84181	broad.mit.edu	37	20	40161984	40161984	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr20:40161984C>A	uc002xka.1	-	3	437	c.259G>T	c.(259-261)GGA>TGA	p.G87*	CHD6_uc002xkd.2_Nonsense_Mutation_p.G65*|CHD6_uc002xkc.2_Nonsense_Mutation_p.G122*	NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	87	Poly-Gly.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GTACCTCCTCCTCCACTGTCC	0.507			NA											15	86					1.05317e-09	6.54331e-09	0.000219431	1	0
STAU1	6780	broad.mit.edu	37	20	47768130	47768130	+	Nonsense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr20:47768130C>A	uc002xud.2	-	5	910	c.499G>T	c.(499-501)GAG>TAG	p.E167*	STAU1_uc002xua.2_Nonsense_Mutation_p.E86*|STAU1_uc002xub.2_Nonsense_Mutation_p.E86*|STAU1_uc002xuc.2_Nonsense_Mutation_p.E86*|STAU1_uc002xue.2_Nonsense_Mutation_p.E86*|STAU1_uc002xuf.2_Nonsense_Mutation_p.E86*|STAU1_uc002xug.2_Nonsense_Mutation_p.E167*	NM_017453	NP_059347	O95793	STAU1_HUMAN	staufen isoform b	167						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			ovary(4)|kidney(1)	5			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			TCCAGCCTCTCTGGCAGGGGC	0.547			NA											15	77					1.15088e-07	6.71512e-07	0.000422831	1	0
ATP9A	10079	broad.mit.edu	37	20	50245520	50245520	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr20:50245520T>A	uc002xwg.1	-	16	1760	c.1760A>T	c.(1759-1761)GAG>GTG	p.E587V	ATP9A_uc010gih.1_Missense_Mutation_p.E451V|ATP9A_uc002xwf.1_Intron	NM_006045	NP_006036	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	587	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(4)	4						CACACTTACCTCTTCCTCCAA	0.448			NA											13	127					0	0	0.00185496	0	0
TAF4	6874	broad.mit.edu	37	20	60551268	60551268	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr20:60551268C>G	uc002ybs.2	-	15	3214	c.3214G>C	c.(3214-3216)GAG>CAG	p.E1072Q		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	1072					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TGGCTTGTCTCACGTTCATTT	0.483			NA											10	89					0	0	0.000673444	0	0
TCF20	6942	broad.mit.edu	37	22	42610586	42610586	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr22:42610586G>A	uc003bcj.1	-	1	860	c.726C>T	c.(724-726)TCC>TCT	p.S242S	TCF20_uc003bck.1_Silent_p.S242S|TCF20_uc003bnt.2_Silent_p.S242S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	242	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						aggaggaggaggaggaggaAG	0.448			NA											10	64					0	0	0.000442599	0	0
PACSIN2	11252	broad.mit.edu	37	22	43272321	43272321	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr22:43272321C>T	uc010gzg.2	-	10	1392	c.1170G>A	c.(1168-1170)AAG>AAA	p.K390K	PACSIN2_uc003bdg.3_Silent_p.K390K|PACSIN2_uc003bde.3_Silent_p.K390K|PACSIN2_uc003bdf.3_Silent_p.K349K	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	390					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				AGCTCTGGGTCTTCTCGTAGC	0.627			NA											4	39					0	0	0.000602214	0	0
WNT7A	7476	broad.mit.edu	37	3	13916540	13916540	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:13916540T>G	uc003bye.1	-	2	507	c.202A>C	c.(202-204)ATG>CTG	p.M68L		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	68					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						TCCAGGCCCATTTGTGAGCCT	0.587			NA											4	42					0	0	0.00024832	0	0
GALNTL2	117248	broad.mit.edu	37	3	16237379	16237379	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:16237379G>T	uc003car.3	+	2	1127	c.652G>T	c.(652-654)GTG>TTG	p.V218L	GALNTL2_uc003caq.3_5'UTR	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	218	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						CCTCGACACAGTGCCCAGGGC	0.617			NA											6	49					3.59834e-05	0.000199544	0.00116845	1	0
KCNH8	131096	broad.mit.edu	37	3	19575178	19575178	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:19575178C>T	uc003cbk.1	+	16	3106	c.2911C>T	c.(2911-2913)CAA>TAA	p.Q971*	KCNH8_uc010hex.1_Nonsense_Mutation_p.Q432*	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	971	Ser-rich.|Cytoplasmic (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						GAGCAGCCCCCAACGAACTGG	0.498	NSCLC(124;1625 1765 8018 24930 42026)		NA											19	69					0	0	0.000958276	0	0
ARPP21	10777	broad.mit.edu	37	3	35763130	35763130	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:35763130G>A	uc003cgb.2	+	14	1293	c.1029G>A	c.(1027-1029)GGG>GGA	p.G343G	ARPP21_uc003cga.2_Silent_p.G289G|ARPP21_uc011axy.1_Silent_p.G309G|ARPP21_uc003cgf.2_Silent_p.G144G|ARPP21_uc003cgg.2_5'UTR	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	343	Ser-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						GAACATCTGGGAGTCGACAGA	0.537			NA											4	32					0	0	0.000602214	0	0
SCN10A	6336	broad.mit.edu	37	3	38739977	38739977	+	Silent	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:38739977G>T	uc003ciq.2	-	27	4734	c.4734C>A	c.(4732-4734)GCC>GCA	p.A1578A		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1578	IV.|Helical; Voltage-sensor; Name=S4 of repeat IV; (Potential).				sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGCCAATTCGGGCCAGGCGGA	0.512			NA											17	60					9.16793e-09	5.54205e-08	0.000566183	1	0
SCN11A	11280	broad.mit.edu	37	3	38889071	38889071	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:38889071A>T	uc011ays.1	-	26	4689	c.4490T>A	c.(4489-4491)CTG>CAG	p.L1497Q		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1497	IV.				response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AATGTTGAACAGAGAAGGAAG	0.473			NA											4	32					0	0	0.00024832	0	0
ZNF445	353274	broad.mit.edu	37	3	44488255	44488255	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:44488255C>G	uc003cnf.2	-	8	3256	c.2908G>C	c.(2908-2910)GAC>CAC	p.D970H	ZNF445_uc011azv.1_Missense_Mutation_p.D958H|ZNF445_uc011azw.1_Missense_Mutation_p.D970H	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	970					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		ATGCTTATGTCCTGGAGTCCA	0.443			NA											36	106					0	0	0.000692331	0	0
ZNF167	55888	broad.mit.edu	37	3	44612782	44612782	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:44612782C>T	uc010hin.2	+	6	2568	c.2180C>T	c.(2179-2181)GCC>GTC	p.A727V	ZNF167_uc003cni.2_Intron|ZNF167_uc010hio.2_Intron|ZNF167_uc003cnj.2_Missense_Mutation_p.A727V|ZNF167_uc003cnk.2_Intron	NM_018651	NP_061121	Q9P0L1	ZN167_HUMAN	zinc finger protein 167 isoform 1	727	C2H2-type 13.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(197;0.0486)|Kidney(197;0.0609)		TGTGGGAAAGCCTTTAGTCAG	0.453	Esophageal Squamous(121;907 1626 38429 48584 52774)		NA											15	95					0	0	0.000308642	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64589620	64589620	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:64589620C>A	uc003dmg.2	-	25	3757	c.3725G>T	c.(3724-3726)TGG>TTG	p.W1242L	ADAMTS9_uc011bfo.1_Missense_Mutation_p.W1214L|ADAMTS9_uc003dmh.1_Missense_Mutation_p.W1071L|ADAMTS9_uc011bfp.1_Missense_Mutation_p.W153L	NM_182920	NP_891550	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1242	TSP type-1 8.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|urinary_tract(1)|skin(1)	4		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAAGGCCTTCCATTGCCCACA	0.557			NA											29	72					1.62565e-12	1.03887e-11	0.000409698	1	0
C3orf38	285237	broad.mit.edu	37	3	88199160	88199160	+	Translation_Start_Site	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:88199160G>T	uc003dqw.2	+	1	268	c.-43G>T	c.(-45--41)TAGGG>TATGG		CGGBP1_uc003dqu.2_5'Flank	NM_173824	NP_776185	Q5JPI3	CC038_HUMAN	hypothetical protein LOC285237						apoptosis						0		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		GTGGGCCGTAGGGGCGACATT	0.622			NA											7	20					5.18039e-06	2.9458e-05	0.000157383	1	0
EPHA6	285220	broad.mit.edu	37	3	97311539	97311539	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:97311539C>A	uc010how.1	+	12	2513	c.2470C>A	c.(2470-2472)CCA>ACA	p.P824T	EPHA6_uc011bgo.1_RNA|EPHA6_uc011bgp.1_Missense_Mutation_p.P190T|EPHA6_uc003drs.3_Missense_Mutation_p.P216T|EPHA6_uc003drr.3_Missense_Mutation_p.P216T|EPHA6_uc003drt.2_Missense_Mutation_p.P216T|EPHA6_uc010hox.1_Intron	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	729	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						GGCCCCGCATCCAGTGCCAGG	0.517			NA											11	21					7.03913e-09	4.27444e-08	0.00136819	1	0
MYH15	22989	broad.mit.edu	37	3	108211363	108211363	+	Silent	SNP	T	T	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:108211363T>C	uc003dxa.1	-	10	972	c.915A>G	c.(913-915)GGA>GGG	p.G305G		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	305	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						GCTCTTTTTGTCCAGATAGAA	0.363			NA											10	24					0	0	0.000442599	0	0
GTF2E1	2960	broad.mit.edu	37	3	120489623	120489623	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:120489623C>T	uc003edz.3	+	3	611	c.497C>T	c.(496-498)TCA>TTA	p.S166L		NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	166					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		GAGGATGAATCAGCAATGCCC	0.418			NA											17	156					0	0	0.00074312	0	0
STXBP5L	9515	broad.mit.edu	37	3	120876378	120876378	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:120876378G>A	uc003eec.3	+	9	921	c.781G>A	c.(781-783)GAG>AAG	p.E261K	STXBP5L_uc011bji.1_Missense_Mutation_p.E261K	NM_014980	NP_055795	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	261	WD 5.				exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				ovary(7)|skin(2)	9				GBM - Glioblastoma multiforme(114;0.0694)		TTGGCATCATGAGGGCAAACA	0.373			NA											7	29					0	0	8.12818e-05	0	0
PLSCR1	5359	broad.mit.edu	37	3	146246609	146246609	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:146246609C>A	uc003evx.3	-	4	492	c.104G>T	c.(103-105)GGA>GTA	p.G35V	PLSCR1_uc003evy.3_Missense_Mutation_p.G28V|PLSCR1_uc011bnn.1_Intron|PLSCR1_uc003evz.3_Intron|PLSCR1_uc003ewa.2_Missense_Mutation_p.G35V	NM_021105	NP_066928	O15162	PLS1_HUMAN	phospholipid scramblase 1	35	Cytoplasmic.|WW-binding 2 (Potential).				phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			ovary(2)	2						GCCACTATATCCTGGAGGTCC	0.498			NA											8	28					1.76689e-08	1.05385e-07	0.000442599	1	0
SSR3	6747	broad.mit.edu	37	3	156272859	156272859	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:156272859G>A	uc003fau.2	-	1	77	c.20C>T	c.(19-21)TCC>TTC	p.S7F	SSR3_uc011bop.1_Missense_Mutation_p.S7F	NM_007107	NP_009038	Q9UNL2	SSRG_HUMAN	signal sequence receptor gamma subunit	7	Lumenal (Potential).				cotranslational protein targeting to membrane	integral to endoplasmic reticulum membrane|microsome|Sec61 translocon complex	protein binding|signal sequence binding				0			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CTGCTGTTTGGAGCTGCCTTT	0.632			NA											6	47					0	0	8.12818e-05	0	0
MUC4	4585	broad.mit.edu	37	3	195498624	195498625	+	Missense_Mutation	DNP	GG	GG	AC			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr3:195498624_195498625GG>AC	uc011bto.1	-	6	13216_13217	c.12756_12757CC>GT	c.(12754-12759)AACCCA>AAGTCA	p.4252_4253NP>KS	MUC4_uc003fuz.2_Missense_Mutation_p.T60S|MUC4_uc003fva.2_Intron|MUC4_uc003fvb.2_Intron|MUC4_uc003fvc.2_Intron|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_5'UTR|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_5'UTR|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_5'UTR|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Missense_Mutation_p.121_122NP>KS|MUC4_uc011btk.1_5'UTR|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Missense_Mutation_p.121_122NP>KS|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Missense_Mutation_p.144_145NP>KS|MUC4_uc003fvp.2_Missense_Mutation_p.93_94NP>KS|MUC4_uc010hzu.1_Missense_Mutation_p.992_993NP>KS	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1137_1138					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GTTGGGAGTGGGTTGGGGTAGG	0.559			NA											6	59					0	0	6.4e-05	0	0
DEFB131	644414	broad.mit.edu	37	4	9452085	9452085	+	Splice_Site	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:9452085G>A	uc011bwt.1	+	2	59	c.59_splice	c.e2-1	p.A20_splice		NM_001040448	NP_001035538	P59861	DB131_HUMAN	defensin, beta 131 precursor						defense response to bacterium	extracellular region					0						TCTTTTTAAAGCCAGAAGCTT	0.279			NA											12	11					0	0	0.000978159	0	0
ZNF518B	85460	broad.mit.edu	37	4	10445956	10445956	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:10445956C>T	uc003gmn.2	-	3	2484	c.1997G>A	c.(1996-1998)CGC>CAC	p.R666H		NM_053042	NP_444270	Q9C0D4	Z518B_HUMAN	zinc finger protein 518B	666					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|upper_aerodigestive_tract(1)	4						TATCTTTCTGCGCAACAGTTC	0.443			NA											34	71					0	0	0.00111076	0	0
SLC34A2	10568	broad.mit.edu	37	4	25674767	25674767	+	Silent	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:25674767C>G	uc003grr.2	+	10	1188	c.1107C>G	c.(1105-1107)CTC>CTG	p.L369L	SLC34A2_uc003grs.2_Silent_p.L368L|SLC34A2_uc010iev.2_Silent_p.L368L	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	369	Helical; Name=M4; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				CCATCTTGCTCATACTCTCCC	0.527			NA											10	106					0	0	0.000673444	0	0
PCDH7	5099	broad.mit.edu	37	4	30726045	30726045	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:30726045C>T	uc003gsk.1	+	1	4009	c.3001C>T	c.(3001-3003)CCA>TCA	p.P1001S	PCDH7_uc011bxw.1_Missense_Mutation_p.P954S|PCDH7_uc011bxx.1_Missense_Mutation_p.P1001S	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1001	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						ATCTAGTTCCCCATTGCCTAC	0.532			NA											9	43					0	0	0.000442599	0	0
KIAA1109	84162	broad.mit.edu	37	4	123269788	123269788	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:123269788C>T	uc003ieh.2	+	75	13241	c.13196C>T	c.(13195-13197)CCA>CTA	p.P4399L	KIAA1109_uc003iem.2_Missense_Mutation_p.P755L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4399					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CAAGGGACCCCATGGGAAACA	0.328			NA											14	33					0	0	0.00185496	0	0
FAT1	2195	broad.mit.edu	37	4	187521447	187521447	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:187521447C>G	uc003izf.2	-	22	11896	c.11708G>C	c.(11707-11709)AGC>ACC	p.S3903T		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3903	Extracellular (Potential).|Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GACCTGAATGCTCTGAACAGA	0.478	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			7	19					0	0	0.000157383	0	0
DNAH5	1767	broad.mit.edu	37	5	13700752	13700752	+	Missense_Mutation	SNP	T	T	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:13700752T>G	uc003jfd.2	-	78	13762	c.13720A>C	c.(13720-13722)AAT>CAT	p.N4574H	DNAH5_uc003jfc.2_Missense_Mutation_p.N742H	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4574					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					AACTTACTATTGTTTTCTGCA	0.383			NA							Kartagener_syndrome				30	104					0	0	0.001512	0	0
C7	730	broad.mit.edu	37	5	40958281	40958281	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:40958281G>T	uc003jmh.2	+	11	1521	c.1407G>T	c.(1405-1407)GAG>GAT	p.E469D	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	469	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				CTACTGTTGAGGGGACCCATT	0.483			NA											36	67					1.36161e-19	9.00141e-19	0.000814825	1	0
C6	729	broad.mit.edu	37	5	41203279	41203279	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:41203279C>A	uc003jmk.2	-	2	264	c.54G>T	c.(52-54)AAG>AAT	p.K18N	C6_uc003jml.1_Missense_Mutation_p.K18N	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	18					complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				AGGCTTGGCCCTTGTTGATCA	0.493			NA											60	161					5.82218e-30	3.92631e-29	0.000781405	1	0
MCTP1	79772	broad.mit.edu	37	5	94224613	94224613	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:94224613G>A	uc003kkx.2	-	12	1904	c.1904C>T	c.(1903-1905)GCG>GTG	p.A635V	MCTP1_uc003kkv.2_Missense_Mutation_p.A414V|MCTP1_uc003kkw.2_Missense_Mutation_p.A368V|MCTP1_uc003kkz.2_Missense_Mutation_p.A296V|MCTP1_uc003kku.2_Missense_Mutation_p.A151V	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	635	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TAACCCTTCCGCTCTGATGAC	0.443			NA											10	77					0	0	0.000308642	0	0
FER	2241	broad.mit.edu	37	5	108203572	108203572	+	Nonsense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:108203572C>T	uc003kop.1	+	6	970	c.586C>T	c.(586-588)CAG>TAG	p.Q196*	FER_uc011cve.1_Nonsense_Mutation_p.Q136*|FER_uc011cvf.1_RNA|FER_uc011cvg.1_Nonsense_Mutation_p.Q21*	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	196	Important for interaction with membranes containing phosphoinositides.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		ACAGCTCCATCAGAATCAGTA	0.388	Colon(146;1051 1799 9836 27344 47401)		NA											8	25					0	0	0.000157383	0	0
MAN2A1	4124	broad.mit.edu	37	5	109124722	109124722	+	Silent	SNP	T	T	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:109124722T>G	uc003kou.1	+	11	2811	c.1848T>G	c.(1846-1848)TCT>TCG	p.S616S		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	616	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CATACGACTCTTACTCTCCTG	0.333			NA											6	69					0	0	0.000673444	0	0
RAPGEF6	51735	broad.mit.edu	37	5	130797726	130797726	+	Missense_Mutation	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:130797726G>C	uc003kvn.1	-	19	2742	c.2536C>G	c.(2536-2538)CAA>GAA	p.Q846E	RAPGEF6_uc003kvp.1_Missense_Mutation_p.Q896E|RAPGEF6_uc003kvo.1_Missense_Mutation_p.Q851E|RAPGEF6_uc010jdi.1_Missense_Mutation_p.Q846E|RAPGEF6_uc010jdj.1_Missense_Mutation_p.Q846E|RAPGEF6_uc003kvq.2_Missense_Mutation_p.Q563E|RAPGEF6_uc003kvr.2_Missense_Mutation_p.Q846E|RAPGEF6_uc011cxe.1_RNA	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	846					Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		ACTAGTTCTTGAGCATCTTCA	0.323	Melanoma(168;435 1955 13113 13877 23213)		NA											5	35					0	0	0.000602214	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182124	140182124	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:140182124G>A	uc003lhf.2	+	1	1342	c.1342G>A	c.(1342-1344)GTG>ATG	p.V448M	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Missense_Mutation_p.V448M	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	448	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCCGACGTGAACGACAA	0.662			NA											15	140					0	0	0.000308642	0	0
PCDHA9	9752	broad.mit.edu	37	5	140230156	140230156	+	Silent	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:140230156G>T	uc003lhu.2	+	1	2800	c.2076G>T	c.(2074-2076)ACG>ACT	p.T692T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Silent_p.T692T	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	692	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGAGGTGACGCTGGTGGATG	0.652	Melanoma(55;1800 1972 14909)		NA											9	76					5.4927e-09	3.36585e-08	0.000274275	1	0
PCDHB16	57717	broad.mit.edu	37	5	140564076	140564076	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:140564076G>T	uc003liv.2	+	1	3097	c.1942G>T	c.(1942-1944)GGC>TGC	p.G648C	PCDHB9_uc003liw.1_5'Flank	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	648	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAAGGACAATGGCGAGCCTCC	0.711			NA											17	50					6.33239e-15	4.08561e-14	0.00152264	1	0
ATP10B	23120	broad.mit.edu	37	5	159992643	159992643	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:159992643C>T	uc003lym.1	-	26	5050	c.4203G>A	c.(4201-4203)CAG>CAA	p.Q1401Q	ATP10B_uc010jit.1_Silent_p.Q651Q	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1401	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGCCACATCTCTGTTCGTGGA	0.547			NA											14	106					0	0	0.000219431	0	0
F13A1	2162	broad.mit.edu	37	6	6267034	6267034	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:6267034G>T	uc003mwv.2	-	4	451	c.328C>A	c.(328-330)CCA>ACA	p.P110T	F13A1_uc011dib.1_Missense_Mutation_p.P47T	NM_000129	NP_000120	P00488	F13A_HUMAN	coagulation factor XIII A1 subunit precursor	110					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|pancreas(1)|skin(1)	6	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	TTCTCCTGTGGGTAGCGACCT	0.453			NA											20	78					3.10358e-05	0.000172822	0.000295444	1	0
GCNT2	2651	broad.mit.edu	37	6	10529657	10529657	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:10529657G>A	uc010joo.2	+	3	1064	c.513G>A	c.(511-513)CTG>CTA	p.L171L	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Silent_p.L170L|GCNT2_uc010jon.2_Silent_p.L170L	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	171	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AGGCTGACCTGAACTGCCTGG	0.517			NA											10	47					0	0	0.000673444	0	0
KIF13A	63971	broad.mit.edu	37	6	17834252	17834252	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:17834252C>T	uc003ncg.3	-	12	1311	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	KIF13A_uc003ncf.2_Silent_p.L402L|KIF13A_uc003nch.3_Silent_p.L402L|KIF13A_uc003nci.3_Silent_p.L402L|KIF13A_uc003ncj.2_Silent_p.L78L	NM_022113	NP_071396	Q9H1H9	KI13A_HUMAN	kinesin family member 13A isoform a	402	Potential.				cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			large_intestine(2)|ovary(2)	4	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			GTTCTTTTATCAGCTTTTCAG	0.378			NA											5	31					0	0	0.000602214	0	0
FAM65B	9750	broad.mit.edu	37	6	24843500	24843500	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:24843500C>T	uc003neo.1	-	14	1686	c.1510G>A	c.(1510-1512)GAC>AAC	p.D504N	FAM65B_uc011djs.1_Missense_Mutation_p.D483N|FAM65B_uc011dju.1_Missense_Mutation_p.D488N|FAM65B_uc003nep.2_Missense_Mutation_p.D454N|FAM65B_uc011djt.1_Missense_Mutation_p.D454N	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	504					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						TCCTCTGGGTCTTCCTCCTTC	0.582			NA											7	44					0	0	0.000274275	0	0
BTN3A3	10384	broad.mit.edu	37	6	26444523	26444523	+	Nonsense_Mutation	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:26444523A>T	uc003nhz.2	+	4	604	c.424A>T	c.(424-426)AAG>TAG	p.K142*	BTN3A3_uc003nia.2_Nonsense_Mutation_p.K100*|BTN3A3_uc011dkn.1_Nonsense_Mutation_p.K100*	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	142	Extracellular (Potential).					integral to membrane					0						GGTGGAGCTGAAGGTTGCAGG	0.488			NA											10	82					0	0	0.000978159	0	0
NKAPL	222698	broad.mit.edu	37	6	28227575	28227575	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:28227575G>T	uc003nkt.2	+	1	478	c.426G>T	c.(424-426)AAG>AAT	p.K142N	ZKSCAN4_uc011dlb.1_5'Flank	NM_001007531	NP_001007532	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	142										upper_aerodigestive_tract(1)|ovary(1)	2						CGTCTCCAAAGTTCCCTCAGC	0.512			NA											20	172					4.30721e-22	2.86152e-21	0.00152264	1	0
BAT3	7917	broad.mit.edu	37	6	31608189	31608189	+	Silent	SNP	T	T	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:31608189T>C	uc003nvg.3	-	22	3335	c.3021A>G	c.(3019-3021)ACA>ACG	p.T1007T	BAT3_uc003nvf.3_Silent_p.T1001T|BAT3_uc003nvh.3_Silent_p.T1001T|BAT3_uc003nvi.3_Silent_p.T1001T|BAT3_uc011dnw.1_Silent_p.T1001T|BAT3_uc011dnx.1_Intron	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	1007					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CCCAAGGTTCTGTCTCAGCTG	0.557			NA											30	124					0	0	0.001512	0	0
SRF	6722	broad.mit.edu	37	6	43146097	43146097	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:43146097C>T	uc003oui.2	+	5	1703	c.1228C>T	c.(1228-1230)CCT>TCT	p.P410S	SRF_uc011dvf.1_Missense_Mutation_p.P206S	NM_003131	NP_003122	P11831	SRF_HUMAN	serum response factor (c-fos serum response	410					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			ovary(1)|breast(1)|central_nervous_system(1)	3			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			CATGATGTACCCTAGCCCGCA	0.617			NA											6	52					0	0	0.000274275	0	0
MRPS18A	55168	broad.mit.edu	37	6	43648835	43648835	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:43648835C>T	uc003ovy.1	-	2	147	c.135G>A	c.(133-135)AAG>AAA	p.K45K	MRPS18A_uc003ovz.1_Silent_p.K45K|MRPS18A_uc003owa.1_Silent_p.K45K|MRPS18A_uc010jyw.2_Silent_p.K45K	NM_018135	NP_060605	Q9NVS2	RT18A_HUMAN	mitochondrial ribosomal protein S18A precursor	45					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome				0	all_cancers(18;6.56e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000479)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0102)|OV - Ovarian serous cystadenocarcinoma(102;0.137)			CTATAGTTGTCTTCCCTTCTT	0.473			NA											4	29					0	0	0.00116845	0	0
EYS	346007	broad.mit.edu	37	6	66205196	66205196	+	Silent	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:66205196G>T	uc011dxu.1	-	4	646	c.108C>A	c.(106-108)CCC>CCA	p.P36P	EYS_uc003peq.2_Silent_p.P36P|EYS_uc003per.1_Silent_p.P36P|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	36					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						CATATGATGAGGGTTGTGGAT	0.388			NA											25	86					7.92952e-12	5.04333e-11	0.000586117	1	0
BAI3	577	broad.mit.edu	37	6	69703681	69703681	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:69703681G>T	uc003pev.3	+	11	2204	c.1756G>T	c.(1756-1758)GGG>TGG	p.G586W	BAI3_uc010kak.2_Missense_Mutation_p.G586W	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	586	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.G586R(1)		lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CCTTGCTAAGGGGCAGCGAAT	0.403			NA											70	186					4.75426e-39	3.22233e-38	0.000781405	1	0
BAI3	577	broad.mit.edu	37	6	70071370	70071370	+	Missense_Mutation	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:70071370A>G	uc003pev.3	+	29	4653	c.4205A>G	c.(4204-4206)GAA>GGA	p.E1402G	BAI3_uc010kak.2_Missense_Mutation_p.E1402G|BAI3_uc011dxx.1_Missense_Mutation_p.E608G	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1402	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TCAAGAAGTGAAACTGGATCA	0.373			NA											12	46					0	0	0.000219431	0	0
MCHR2	84539	broad.mit.edu	37	6	100403872	100403872	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:100403872C>A	uc003pqh.1	-	2	467	c.152G>T	c.(151-153)GGC>GTC	p.G51V	MCHR2_uc003pqi.1_Missense_Mutation_p.G51V	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	51	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GAGGATGTTGCCAACCAGCCC	0.383			NA											10	41					1.76689e-08	1.05385e-07	0.000442599	1	0
SAMD3	154075	broad.mit.edu	37	6	130530743	130530743	+	Missense_Mutation	SNP	C	C	T	rs17852709		TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:130530743C>T	uc003qbv.2	-	6	606	c.280G>A	c.(280-282)GAA>AAA	p.E94K	SAMD3_uc003qbx.2_Missense_Mutation_p.E94K|SAMD3_uc003qbw.2_Missense_Mutation_p.E94K|SAMD3_uc010kfg.1_Missense_Mutation_p.E94K|SAMD3_uc003qby.2_Missense_Mutation_p.E94K|SAMD3_uc003qbz.1_Missense_Mutation_p.E53K	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	94										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GAGGACTCTTCATCCCTGTAA	0.468			NA											6	39					0	0	0.00116845	0	0
AHI1	54806	broad.mit.edu	37	6	135784321	135784321	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:135784321G>A	uc003qgi.2	-	8	1257	c.873C>T	c.(871-873)GAC>GAT	p.D291D	AHI1_uc003qgh.2_Silent_p.D291D|AHI1_uc003qgj.2_Silent_p.D291D|AHI1_uc003qgk.3_RNA|AHI1_uc003qgl.3_Silent_p.D291D	NM_001134831	NP_001128303	Q8N157	AHI1_HUMAN	Abelson helper integration site 1 isoform a	291						adherens junction|cilium|microtubule basal body				ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		CTTGCATGCTGTCTTCTGTGC	0.323			NA											7	73					0	0	8.12818e-05	0	0
RBM16	22828	broad.mit.edu	37	6	155095170	155095170	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:155095170G>A	uc003qqa.2	+	3	310	c.78G>A	c.(76-78)ATG>ATA	p.M26I	RBM16_uc011efj.1_Missense_Mutation_p.M92I|RBM16_uc011efk.1_Missense_Mutation_p.M71I|RBM16_uc003qpz.2_Missense_Mutation_p.M26I|RBM16_uc010kji.2_Missense_Mutation_p.M47I	NM_014892	NP_055707	Q9UPN6	SCAF8_HUMAN	RNA-binding motif protein 16	26	CID.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding				0		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;2.33e-15)|BRCA - Breast invasive adenocarcinoma(81;0.00524)		AAGCGAAAATGACCCAAATTA	0.318			NA											30	74					0	0	0.000692331	0	0
EZR	7430	broad.mit.edu	37	6	159206352	159206352	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr6:159206352C>T	uc003qrt.3	-	4	671	c.456G>A	c.(454-456)CTG>CTA	p.L152L	EZR_uc011efs.1_Silent_p.L120L|EZR_uc003qru.3_Silent_p.L152L	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	152	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TTTGAGGGATCAGCCGCTCAG	0.562			NA											10	50					0	0	0.000978159	0	0
RNF216	54476	broad.mit.edu	37	7	5760666	5760666	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:5760666C>T	uc003soy.1	-	9	1661	c.1471G>A	c.(1471-1473)GAG>AAG	p.E491K	RNF216_uc010ksz.1_Missense_Mutation_p.E113K|RNF216_uc010kta.1_Missense_Mutation_p.E113K|RNF216_uc011jwj.1_Missense_Mutation_p.E113K|RNF216_uc003sox.1_Missense_Mutation_p.E548K	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	491	Potential.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		CTTCCTACCTCTGCCATCTCT	0.443			NA											10	163					0	0	0.000673444	0	0
COL28A1	340267	broad.mit.edu	37	7	7472294	7472294	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:7472294C>A	uc003src.1	-	24	2015	c.1898G>T	c.(1897-1899)GGA>GTA	p.G633V	COL28A1_uc011jxe.1_Missense_Mutation_p.G316V|COL28A1_uc003srd.2_Missense_Mutation_p.G188V|COL28A1_uc003sre.1_Missense_Mutation_p.G54V	NM_001037763	NP_001032852	Q2UY09	COSA1_HUMAN	collagen, type XXVIII precursor	633					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			skin(3)	3		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		ACCTTTGAGTCCTGGAGCACC	0.488			NA											61	89					1.3268e-25	8.90285e-25	0.000781405	1	0
HDAC9	9734	broad.mit.edu	37	7	18688173	18688173	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:18688173G>A	uc003suh.2	+	10	1366	c.1325G>A	c.(1324-1326)CGT>CAT	p.R442H	HDAC9_uc003sue.2_Missense_Mutation_p.R442H|HDAC9_uc011jyd.1_Missense_Mutation_p.R442H|HDAC9_uc003sui.2_Missense_Mutation_p.R445H|HDAC9_uc003suj.2_Missense_Mutation_p.R401H|HDAC9_uc011jya.1_Missense_Mutation_p.R439H|HDAC9_uc003sua.1_Missense_Mutation_p.R420H|HDAC9_uc011jyb.1_Missense_Mutation_p.R398H|HDAC9_uc003sud.1_Missense_Mutation_p.R442H|HDAC9_uc011jyc.1_Missense_Mutation_p.R401H|HDAC9_uc003suf.1_Missense_Mutation_p.R473H|HDAC9_uc010kud.1_Missense_Mutation_p.R445H|HDAC9_uc011jye.1_Missense_Mutation_p.R414H|HDAC9_uc011jyf.1_Missense_Mutation_p.R365H|HDAC9_uc010kue.1_Missense_Mutation_p.R185H	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	442					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	AAATTGCCCCGTCACAGACCC	0.493			NA											7	100					0	0	0.000157383	0	0
DFNA5	1687	broad.mit.edu	37	7	24749972	24749972	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:24749972C>T	uc010kus.1	-	6	821	c.733G>A	c.(733-735)GAG>AAG	p.E245K	DFNA5_uc003swz.2_Missense_Mutation_p.E81K|DFNA5_uc003sxa.1_Missense_Mutation_p.E245K|DFNA5_uc010kut.1_Missense_Mutation_p.E81K	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	245					sensory perception of sound					ovary(1)	1						TTCTTGTTCTCGAAGCCACCT	0.488	GBM(78;184 1250 20134 20900 23600)		NA											13	117					0	0	0.000219431	0	0
CCT6A	908	broad.mit.edu	37	7	56122154	56122154	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:56122154C>G	uc003trl.1	+	3	458	c.294C>G	c.(292-294)ATC>ATG	p.I98M	PSPH_uc003trh.2_5'Flank|PSPH_uc003tri.2_5'Flank|PSPH_uc003trj.2_Intron|PSPH_uc003trk.1_5'Flank|CCT6A_uc003trm.1_Intron|CCT6A_uc011kcu.1_Missense_Mutation_p.I67M	NM_001762	NP_001753	P40227	TCPZ_HUMAN	chaperonin containing TCP1, subunit 6A isoform	98					'de novo' posttranslational protein folding	cytosol	ATP binding|unfolded protein binding			upper_aerodigestive_tract(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			ATGTCCTAATCATTGGAGAGC	0.383			NA											16	183					0	0	0.00074312	0	0
PCLO	27445	broad.mit.edu	37	7	82785429	82785429	+	Silent	SNP	A	A	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:82785429A>G	uc003uhx.2	-	2	817	c.528T>C	c.(526-528)TTT>TTC	p.F176F	PCLO_uc003uhv.2_Silent_p.F176F	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	176					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATATCAAATCAAAAGGGTTGA	0.403			NA											7	53					0	0	0.000157383	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628881	84628881	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:84628881T>A	uc003uic.2	-	17	2249	c.2209A>T	c.(2209-2211)AGG>TGG	p.R737W	SEMA3D_uc010led.2_Missense_Mutation_p.R737W|SEMA3D_uc003uib.2_Missense_Mutation_p.R376W	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	737					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						CGCTTCTCCCTGTGCCACATC	0.493	Ovarian(63;442 1191 17318 29975 31528)		NA											5	65					0	0	0.00116845	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761372	92761372	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:92761372C>T	uc003umh.1	-	5	5129	c.3913G>A	c.(3913-3915)GAA>AAA	p.E1305K	SAMD9L_uc003umj.1_Missense_Mutation_p.E1305K|SAMD9L_uc003umi.1_Missense_Mutation_p.E1305K|SAMD9L_uc010lfb.1_Missense_Mutation_p.E1305K|SAMD9L_uc003umk.1_Missense_Mutation_p.E1305K|SAMD9L_uc010lfc.1_Missense_Mutation_p.E1305K|SAMD9L_uc010lfd.1_Missense_Mutation_p.E1305K|SAMD9L_uc011khx.1_Intron	NM_152703	NP_689916	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1305										ovary(4)	4	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CAGAAAAGTTCTGTGTATTTC	0.358			NA											9	73					0	0	0.000274275	0	0
COL1A2	1278	broad.mit.edu	37	7	94053707	94053707	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:94053707C>T	uc003ung.1	+	41	3096	c.2625C>T	c.(2623-2625)CTC>CTT	p.L875L	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_RNA	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	875					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	TTCTGGGTCTCCCTGGCTCGA	0.468			NA								HNSCC(75;0.22)			12	82					0	0	0.00185496	0	0
CPSF4	10898	broad.mit.edu	37	7	99051673	99051674	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:99051673_99051674CC>AA	uc003uqj.2	+	7	798_799	c.655_656CC>AA	c.(655-657)CCG>AAG	p.P219K	PTCD1_uc011kiw.1_Intron|CPSF4_uc003uqi.2_Missense_Mutation_p.P194K|CPSF4_uc003uqk.2_Missense_Mutation_p.P193K|CPSF4_uc011kix.1_Missense_Mutation_p.P141K	NM_006693	NP_006684	O95639	CPSF4_HUMAN	cleavage and polyadenylation specific factor 4,	219					modification by virus of host mRNA processing|mRNA processing|viral infectious cycle	mRNA cleavage and polyadenylation specificity factor complex	RNA binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCAGAGAACCCCGCAGGTCATC	0.554			NA											9	291					0	0	6.4e-05	0	0
DOCK4	9732	broad.mit.edu	37	7	111368635	111368635	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:111368635C>T	uc003vfx.2	-	52	5865	c.5596G>A	c.(5596-5598)GAA>AAA	p.E1866K	DOCK4_uc011kml.1_Missense_Mutation_p.E747K|DOCK4_uc011kmm.1_Missense_Mutation_p.E735K|DOCK4_uc003vfw.2_Missense_Mutation_p.E1278K|DOCK4_uc003vfy.2_Missense_Mutation_p.E1911K|DOCK4_uc003vfv.2_Missense_Mutation_p.E179K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1866					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				ACCTGATTTTCAAAGCCTGAG	0.622			NA											10	61					0	0	0.00136819	0	0
MET	4233	broad.mit.edu	37	7	116371843	116371843	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:116371843C>G	uc003vij.2	+	3	1509	c.1322C>G	c.(1321-1323)TCT>TGT	p.S441C	MET_uc010lkh.2_Missense_Mutation_p.S441C|MET_uc011knc.1_Missense_Mutation_p.S441C|MET_uc011knd.1_Missense_Mutation_p.S441C|MET_uc011kne.1_Missense_Mutation_p.S441C|MET_uc011knf.1_Missense_Mutation_p.S441C|MET_uc011kng.1_Missense_Mutation_p.S441C|MET_uc011knh.1_Missense_Mutation_p.S441C|MET_uc011kni.1_Missense_Mutation_p.S441C|MET_uc011knj.1_Missense_Mutation_p.S11C|MET_uc010lkg.2_Missense_Mutation_p.S441C|MET_uc011kna.1_Missense_Mutation_p.S441C|MET_uc011knb.1_Missense_Mutation_p.S441C	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor	441	Extracellular (Potential).|Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTCTTAACATCTATATCCACC	0.473			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				6	49					0	0	0.000157383	0	0
CHRM2	1129	broad.mit.edu	37	7	136700368	136700368	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:136700368C>G	uc003vtf.1	+	4	1379	c.756C>G	c.(754-756)GAC>GAG	p.D252E	CHRM2_uc003vtg.1_Missense_Mutation_p.D252E|CHRM2_uc003vtj.1_Missense_Mutation_p.D252E|CHRM2_uc003vtk.1_Missense_Mutation_p.D252E|CHRM2_uc003vtl.1_Missense_Mutation_p.D252E|CHRM2_uc003vtm.1_Missense_Mutation_p.D252E|CHRM2_uc003vti.1_Missense_Mutation_p.D252E|CHRM2_uc003vto.1_Missense_Mutation_p.D252E|CHRM2_uc003vtn.1_Missense_Mutation_p.D252E|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	252	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCAGCAGTGACGATGGCCTGG	0.507			NA											3	30					0	0	6.4e-05	0	0
NOBOX	135935	broad.mit.edu	37	7	144098962	144098962	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:144098962C>G	uc011kue.1	-	3	292	c.292G>C	c.(292-294)GGC>CGC	p.G98R		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	98					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					GGGTACTCACCCCTTGTGAGT	0.443			NA											5	15					0	0	0.00116845	0	0
CSMD1	64478	broad.mit.edu	37	8	4851884	4851884	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:4851884G>T	uc011kwk.1	-	1	445	c.55C>A	c.(55-57)CTG>ATG	p.L19M		NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	19						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTCGCGCACAGCACCAGCAGC	0.657			NA											4	30					1.024e-07	6.02723e-07	0.000602214	1	0
RP1L1	94137	broad.mit.edu	37	8	10469299	10469299	+	Missense_Mutation	SNP	G	G	T	rs151054713	by1000genomes	TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:10469299G>T	uc003wtc.2	-	4	2538	c.2309C>A	c.(2308-2310)ACA>AAA	p.T770K		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	770					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		CGGCGAGCATGTCCTGGACCC	0.662			NA											9	42					2.17888e-05	0.000121836	0.000442599	1	0
PTK2B	2185	broad.mit.edu	37	8	27277480	27277480	+	Silent	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:27277480G>T	uc003xfn.1	+	8	1081	c.273G>T	c.(271-273)GGG>GGT	p.G91G	PTK2B_uc003xfo.1_Silent_p.G91G|PTK2B_uc003xfp.1_Silent_p.G91G|PTK2B_uc003xfq.1_Silent_p.G91G	NM_173174	NP_775266	Q14289	FAK2_HUMAN	PTK2B protein tyrosine kinase 2 beta isoform a	91	FERM.				apoptosis|bone resorption|positive regulation of cell proliferation|signal complex assembly	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|signal transducer activity			lung(3)|ovary(1)|skin(1)	5		Ovarian(32;2.72e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|Epithelial(17;6.61e-10)|BRCA - Breast invasive adenocarcinoma(99;0.226)|Colorectal(74;0.229)		AGTGCTATGGGCTGAGGCTGA	0.582			NA											11	31					1.67772e-17	1.09296e-16	0.000978159	1	0
SOX17	64321	broad.mit.edu	37	8	55371727	55371727	+	Silent	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:55371727G>C	uc003xsb.3	+	2	621	c.417G>C	c.(415-417)CCG>CCC	p.P139P		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	139					angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			AGTACCGGCCGCGGCGGCGCA	0.736			NA											3	38					0	0	0.000602214	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764192	77764192	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:77764192A>T	uc003yav.2	+	10	5287	c.4900A>T	c.(4900-4902)ATC>TTC	p.I1634F	ZFHX4_uc003yau.1_Missense_Mutation_p.I1679F|ZFHX4_uc003yaw.1_Missense_Mutation_p.I1634F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1634						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCCTGATTTAATCTCTGCTCA	0.428			NA								HNSCC(33;0.089)			5	106					0	0	0.000602214	0	0
ANGPT1	284	broad.mit.edu	37	8	108348418	108348418	+	Nonsense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:108348418G>A	uc003ymn.2	-	3	1003	c.535C>T	c.(535-537)CAA>TAA	p.Q179*	ANGPT1_uc011lhv.1_5'UTR|ANGPT1_uc003ymo.2_Nonsense_Mutation_p.Q179*	NM_001146	NP_001137	Q15389	ANGP1_HUMAN	angiopoietin 1 precursor	179	Potential.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			ovary(3)|skin(3)|upper_aerodigestive_tract(1)	7	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			TTTGTCTGTTGAAGAAGTTGC	0.343			NA											14	38					0	0	0.000308642	0	0
CSMD3	114788	broad.mit.edu	37	8	113504872	113504872	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:113504872C>A	uc003ynu.2	-	31	5283	c.5124G>T	c.(5122-5124)ATG>ATT	p.M1708I	CSMD3_uc003yns.2_Missense_Mutation_p.M980I|CSMD3_uc003ynt.2_Missense_Mutation_p.M1668I|CSMD3_uc011lhx.1_Missense_Mutation_p.M1604I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1708	Extracellular (Potential).|Sushi 9.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGGTGCCATTCATTATATTGC	0.328			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	69					1.30998e-17	8.5756e-17	0.00111076	1	0
ENPP2	5168	broad.mit.edu	37	8	120569904	120569904	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:120569904C>T	uc003yot.1	-	25	2535	c.2449G>A	c.(2449-2451)GAA>AAA	p.E817K	ENPP2_uc011lic.1_Missense_Mutation_p.E355K|ENPP2_uc003yor.1_Missense_Mutation_p.E452K|ENPP2_uc003yos.1_Missense_Mutation_p.E869K|ENPP2_uc010mdd.1_Missense_Mutation_p.E842K	NM_001040092	NP_001035181	Q13822	ENPP2_HUMAN	autotaxin isoform 2 preproprotein	817					cellular component movement|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|phosphate metabolic process|phosphatidylcholine catabolic process|regulation of cell migration	extracellular space|integral to plasma membrane	alkylglycerophosphoethanolamine phosphodiesterase activity|calcium ion binding|lysophospholipase activity|nucleic acid binding|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity|transcription factor binding|zinc ion binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)|kidney(1)	7	Lung NSC(37;5.03e-06)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			ATGAGTTCTTCTACCCATTTT	0.458	Melanoma(20;305 879 2501 4818 31020)		NA											9	176					0	0	0.000673444	0	0
FAM135B	51059	broad.mit.edu	37	8	139323096	139323096	+	Missense_Mutation	SNP	C	C	G			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:139323096C>G	uc003yuy.2	-	3	316	c.145G>C	c.(145-147)GCT>CCT	p.A49P	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	49										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTCTGCCCAGCGATGGAGGCA	0.557			NA								HNSCC(54;0.14)			3	79					0	0	0.00024832	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996466	143996466	+	Missense_Mutation	SNP	T	T	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:143996466T>C	uc003yxk.1	-	3	594	c.591A>G	c.(589-591)ATA>ATG	p.I197M		NM_000498	NP_000489	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B,	197					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity				0	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CCACACCTTCTATGGTGTAGT	0.647			NA							Familial_Hyperaldosteronism_type_I				10	21					0	0	0.000442599	0	0
EPPK1	83481	broad.mit.edu	37	8	144941387	144941387	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr8:144941387G>A	uc003zaa.1	-	1	6048	c.6035C>T	c.(6034-6036)GCC>GTC	p.A2012V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2012	Plectin 34.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCCCCCGTGGCCACCTGCAC	0.627			NA											19	33					0	0	0.00074312	0	0
FOXD4	2298	broad.mit.edu	37	9	118076	118076	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr9:118076C>T	uc003zfz.2	-	1	342	c.44G>A	c.(43-45)CGC>CAC	p.R15H		NM_207305	NP_997188	Q12950	FOXD4_HUMAN	forkhead box D4	15					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CCGGAGGCTGCGCTGCGGTGT	0.642			NA											16	189					0	0	0.00074312	0	0
CER1	9350	broad.mit.edu	37	9	14720260	14720260	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr9:14720260G>A	uc003zlj.2	-	2	677	c.632C>T	c.(631-633)CCT>CTT	p.P211L		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	211	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		GAACTTGGCAGGCAAACAGTG	0.522			NA											19	57					0	0	0.000958276	0	0
ELAVL2	1993	broad.mit.edu	37	9	23693456	23693456	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr9:23693456C>T	uc003zpu.2	-	6	1017	c.742G>A	c.(742-744)GGA>AGA	p.G248R	ELAVL2_uc003zps.2_Intron|ELAVL2_uc003zpt.2_Intron|ELAVL2_uc003zpv.2_Missense_Mutation_p.G248R|ELAVL2_uc003zpw.2_Intron	NM_004432	NP_004423	Q12926	ELAV2_HUMAN	ELAV (embryonic lethal, abnormal vision,	248					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CTCTTTACTCCATAAGCCATA	0.378			NA											12	83					0	0	0.00185496	0	0
PCSK5	5125	broad.mit.edu	37	9	78722189	78722189	+	Missense_Mutation	SNP	G	G	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr9:78722189G>T	uc004ajz.2	+	9	1668	c.1130G>T	c.(1129-1131)CGT>CTT	p.R377L	PCSK5_uc004ajy.2_Missense_Mutation_p.R377L|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	377	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CTGAGGCAGCGTTGCACGGAC	0.478			NA											11	43					4.68919e-08	2.7722e-07	0.000673444	1	0
COL15A1	1306	broad.mit.edu	37	9	101812151	101812151	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr9:101812151C>A	uc004azb.1	+	30	3084	c.2878C>A	c.(2878-2880)CCC>ACC	p.P960T		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	960	Nonhelical region 6 (NC6).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TTTCCCAATACCCGTCCGACC	0.493			NA											11	97					0.00136819	0.00734447	0.00136819	1	0
PPP3R2	5535	broad.mit.edu	37	9	104356919	104356919	+	Silent	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr9:104356919C>T	uc004bbr.2	-	1	365	c.294G>A	c.(292-294)GCG>GCA	p.A98A	GRIN3A_uc004bbp.1_Intron|GRIN3A_uc004bbq.1_Intron|PPP3R2_uc010mtf.1_RNA	NM_147180	NP_671709	Q96LZ3	CANB2_HUMAN	protein phosphatase 3 regulatory subunit B, beta	95	EF-hand 3.						calcium ion binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)			Cyclosporine(DB00091)	AAATGCTGAACGCAAACCTCA	0.537			NA											16	88					0	0	0.000422831	0	0
TBL1X	6907	broad.mit.edu	37	X	9660219	9660219	+	Silent	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:9660219C>A	uc010ndq.2	+	9	1184	c.816C>A	c.(814-816)CTC>CTA	p.L272L	TBL1X_uc004csq.3_Silent_p.L221L|TBL1X_uc010ndr.2_Silent_p.L221L|TBL1X_uc004csr.2_Silent_p.L272L|TBL1X_uc004css.2_Silent_p.L223L	NM_001139466	NP_001132938	O60907	TBL1X_HUMAN	transducin beta-like 1X isoform a	272					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Hepatocellular(5;0.000888)				CCACCCAGCTCGTGTTGAGGC	0.522			NA											18	97					3.32936e-07	1.92586e-06	0.00074312	1	0
IL1RAPL1	11141	broad.mit.edu	37	X	29414549	29414549	+	Silent	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:29414549C>A	uc004dby.2	+	4	1045	c.537C>A	c.(535-537)ATC>ATA	p.I179I		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	179	Ig-like C2-type 2.|Extracellular (Potential).				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						AACCTGAAATCCTTTGGTACA	0.378			NA											13	64					3.27435e-08	1.94433e-07	0.000219431	1	0
MAGEB16	139604	broad.mit.edu	37	X	35820400	35820400	+	Silent	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:35820400G>A	uc010ngt.1	+	2	366	c.87G>A	c.(85-87)CAG>CAA	p.Q29Q		NM_001099921	NP_001093391	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	29										lung(3)|ovary(2)|breast(1)|skin(1)	7						AGGTTGCACAGGTCTCCAAGG	0.557			NA											7	27					0	0	8.12818e-05	0	0
DGKK	139189	broad.mit.edu	37	X	50133388	50133388	+	Missense_Mutation	SNP	C	C	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:50133388C>T	uc010njr.1	-	12	1924	c.1864G>A	c.(1864-1866)GAG>AAG	p.E622K		NM_001013742	NP_001013764	Q5KSL6	DGKK_HUMAN	diacylglycerol kinase kappa	622	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)	2	Ovarian(276;0.236)					CTGGGAGTCTCACGAATCATC	0.398			NA											23	119					0	0	0.00047179	0	0
BRWD3	254065	broad.mit.edu	37	X	79932261	79932261	+	Missense_Mutation	SNP	T	T	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:79932261T>A	uc004edt.2	-	41	5519	c.5256A>T	c.(5254-5256)CAA>CAT	p.Q1752H	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.Q1348H|BRWD3_uc004edp.2_Missense_Mutation_p.Q1581H|BRWD3_uc004edq.2_Missense_Mutation_p.Q1348H|BRWD3_uc010nmj.1_Missense_Mutation_p.Q1348H|BRWD3_uc004edr.2_Missense_Mutation_p.Q1422H|BRWD3_uc004eds.2_Missense_Mutation_p.Q1348H|BRWD3_uc004edu.2_Missense_Mutation_p.Q1422H|BRWD3_uc004edv.2_Missense_Mutation_p.Q1348H|BRWD3_uc004edw.2_Missense_Mutation_p.Q1348H|BRWD3_uc004edx.2_Missense_Mutation_p.Q1348H|BRWD3_uc004edy.2_Missense_Mutation_p.Q1348H|BRWD3_uc004edz.2_Missense_Mutation_p.Q1422H|BRWD3_uc004eea.2_Missense_Mutation_p.Q1422H|BRWD3_uc004eeb.2_Missense_Mutation_p.Q1348H|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1752										ovary(4)	4						TCCTCCTGCCTTGGTTTCTTG	0.418			NA											12	59					0	0	0.00136819	0	0
DCX	1641	broad.mit.edu	37	X	110654193	110654193	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:110654193G>A	uc004epd.2	-	1	182	c.10C>T	c.(10-12)CTC>TTC	p.L4F	DCX_uc011msv.1_Missense_Mutation_p.L4F|DCX_uc004epe.2_Intron|DCX_uc004epf.2_Intron|DCX_uc004epg.2_Intron	NM_000555	NP_000546	O43602	DCX_HUMAN	doublecortin isoform a	4					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			central_nervous_system(2)|lung(1)|skin(1)	4						TGAAGGGGGAGTGTTTTCATT	0.453			NA											12	84					0	0	0.00136819	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298801	125298801	+	Missense_Mutation	SNP	A	A	T			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:125298801A>T	uc004euk.1	-	1	1134	c.1107T>A	c.(1105-1107)CAT>CAA	p.H369Q		NM_001013628	NP_001013650	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	369	WD 4.									lung(2)|skin(2)|large_intestine(1)|pancreas(1)|ovary(1)	7						GCAGGGAACCATGGCCGGTGC	0.642			NA											13	80					0	0	0.000308642	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795254	142795254	+	Missense_Mutation	SNP	C	C	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:142795254C>A	uc004fbz.2	-	2	1178	c.424G>T	c.(424-426)GAC>TAC	p.D142Y		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	142										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATGAGTCCAGGTCTTCG	0.512			NA											88	306					1.67448e-56	1.14068e-55	0.000781405	1	0
SLITRK2	84631	broad.mit.edu	37	X	144905488	144905488	+	Silent	SNP	G	G	C			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:144905488G>C	uc004fcd.2	+	5	2535	c.1545G>C	c.(1543-1545)CTG>CTC	p.L515L	SLITRK2_uc010nsp.2_Silent_p.L515L|SLITRK2_uc010nso.2_Silent_p.L515L|SLITRK2_uc011mwq.1_Silent_p.L515L|SLITRK2_uc011mwr.1_Silent_p.L515L|SLITRK2_uc011mws.1_Silent_p.L515L|SLITRK2_uc004fcg.2_Silent_p.L515L|SLITRK2_uc011mwt.1_Silent_p.L515L	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	515	Extracellular (Potential).|LRR 12.					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGGGTTCTGGATCAGCTCC	0.502			NA											13	104					0	0	0.00185496	0	0
CNGA2	1260	broad.mit.edu	37	X	150912290	150912290	+	Missense_Mutation	SNP	G	G	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chrX:150912290G>A	uc004fey.1	+	7	1539	c.1315G>A	c.(1315-1317)GAG>AAG	p.E439K		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	439	Extracellular (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GCTCAGGGCTGAGATAGCCAT	0.498			NA											12	81					0	0	0.00136819	0	0
TRPC6	7225	broad.mit.edu	37	11	101323821	101323821	+	Frame_Shift_Del	DEL	A	A	-			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr11:101323821delA	uc001pgk.3	-	13	3086	c.2661delT	c.(2659-2661)ATTfs	p.I887fs	TRPC6_uc009ywy.2_Frame_Shift_Del_p.I771fs	NM_004621	NP_004612	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel,	887	Cytoplasmic (Potential).				axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGTCCTGCTTAATTTCCTTCA	0.393	Colon(166;1315 1927 11094 12848 34731)		NA											12	68	---	---	---	---	NA	NA	NA	NA	NA
TIFA	92610	broad.mit.edu	37	4	113199144	113199145	+	Frame_Shift_Ins	INS	-	-	A			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr4:113199144_113199145insA	uc003ial.2	-	2	710_711	c.428_429insT	c.(427-429)TTAfs	p.L143fs		NM_052864	NP_443096	Q96CG3	TIFA_HUMAN	TRAF-interacting protein with a	143							protein binding			breast(1)	1		Ovarian(17;0.0443)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00172)		ATCTTGGAGATAAAATAAATTG	0.465			NA											7	39	---	---	---	---	NA	NA	NA	NA	NA
APC	324	broad.mit.edu	37	5	112177967	112177968	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr5:112177967_112177968delCG	uc010jby.2	+	16	7056_7057	c.6676_6677delCG	c.(6676-6678)CGAfs	p.R2226fs	APC_uc011cvt.1_Frame_Shift_Del_p.R2208fs|APC_uc003kpz.3_Frame_Shift_Del_p.R2226fs|APC_uc003kpy.3_Frame_Shift_Del_p.R2226fs|APC_uc010jbz.2_Frame_Shift_Del_p.R1943fs|APC_uc010jca.2_Frame_Shift_Del_p.R1526fs	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2226	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTCAATCTCTCGAGGCAGGACA	0.401	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			19	125	---	---	---	---	NA	NA	NA	NA	NA
DDX56	54606	broad.mit.edu	37	7	44610424	44610424	+	Frame_Shift_Del	DEL	T	T	-			TCGA-49-6761-01A-31D-1945-08	TCGA-49-6761-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	5721b714-3c3e-49e8-b301-25727fd130cd	24721de3-4572-4864-9ba5-1f54a9023005	g.chr7:44610424delT	uc003tlg.2	-	7	1586	c.943delA	c.(943-945)ACTfs	p.T315fs	DDX56_uc003tle.2_RNA|DDX56_uc003tlf.2_Frame_Shift_Del_p.T251fs|DDX56_uc003tlh.2_RNA|DDX56_uc010kyg.2_Intron|DDX56_uc010kyh.1_RNA	NM_019082	NP_061955	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	315	Helicase C-terminal.				rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			upper_aerodigestive_tract(1)	1						TCAGCATCAGTTGCTATGACA	0.572			NA											100	113	---	---	---	---	NA	NA	NA	NA	NA