Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PLCH2	9651	broad.mit.edu	37	1	2420731	2420731	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:2420731G>A	uc001aji.1	+	9	1595	c.1321G>A	c.(1321-1323)GAC>AAC	p.D441N	PLCH2_uc010nyz.1_Missense_Mutation_p.D229N|PLCH2_uc009vle.1_Missense_Mutation_p.D229N|PLCH2_uc001ajj.1_Missense_Mutation_p.D229N|PLCH2_uc001ajk.1_Missense_Mutation_p.D229N	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	441	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		CATCCTTGGGGACAAGCTGGA	0.552			NA											16	65					0	0	0.004007	0	0
ATP13A2	23400	broad.mit.edu	37	1	17331296	17331296	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:17331296G>A	uc001baa.2	-	5	558	c.368C>T	c.(367-369)TCC>TTC	p.S123F	ATP13A2_uc001bab.2_Missense_Mutation_p.S123F|ATP13A2_uc001bac.2_Missense_Mutation_p.S123F	NM_022089	NP_071372	Q9NQ11	AT132_HUMAN	ATPase type 13A2 isoform 1	123	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		CTCTGCCTGGGACTGTGGGGA	0.662			NA											13	78					0	0	0.00245	0	0
PADI4	23569	broad.mit.edu	37	1	17666217	17666217	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:17666217G>A	uc001baj.2	+	6	589	c.561G>A	c.(559-561)ACG>ACA	p.T187T	PADI4_uc009vpc.2_Silent_p.T187T	NM_012387	NP_036519	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	187					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			ovary(1)|skin(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCCTGAGCACGAAGACCCCCA	0.562			NA											9	37					0	0	0.004482	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17991008	17991008	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:17991008C>G	uc001ban.2	+	26	3086	c.2927C>G	c.(2926-2928)ACC>AGC	p.T976S	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.T937S|ARHGEF10L_uc001bao.2_Missense_Mutation_p.T937S|ARHGEF10L_uc001bap.2_Missense_Mutation_p.T932S|ARHGEF10L_uc001baq.2_Missense_Mutation_p.T737S|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.T749S|ARHGEF10L_uc001bar.2_Missense_Mutation_p.T679S|ARHGEF10L_uc009vpf.2_RNA	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	976					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		CCTGTCCGCACCCTGTTGAGC	0.672			NA											5	18					0	0	0.001984	0	0
BSND	7809	broad.mit.edu	37	1	55472787	55472787	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:55472787C>T	uc001cye.2	+	3	633	c.390C>T	c.(388-390)TCC>TCT	p.S130S		NM_057176	NP_476517	Q8WZ55	BSND_HUMAN	barttin	130	Cytoplasmic (Potential).					basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				ovary(1)|skin(1)	2						ACCACCGCTCCTTGCTGGCCC	0.607	Ovarian(191;1657 2078 22894 42033 48899)		NA											5	55					0	0	0.001984	0	0
KANK4	163782	broad.mit.edu	37	1	62740490	62740490	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:62740490G>T	uc001dah.3	-	3	663	c.286C>A	c.(286-288)CCA>ACA	p.P96T	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	96										ovary(3)|skin(2)|lung(1)	6						GCCTCCCTTGGCACCACGGGA	0.612			NA											16	100					2.48551e-13	3.69662e-13	0.00499	1	0
LRRIQ3	127255	broad.mit.edu	37	1	74507380	74507380	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:74507380C>T	uc001dfy.3	-	7	1427	c.1235G>A	c.(1234-1236)AGA>AAA	p.R412K	LRRIQ3_uc001dfz.3_RNA	NM_001105659	NP_001099129	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	412										ovary(2)	2						CATACCAGCTCTTTGTGGTGC	0.368			NA											37	82					0	0	0.004878	0	0
C1orf173	127254	broad.mit.edu	37	1	75086594	75086594	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:75086594G>C	uc001dgg.2	-	8	1043	c.824C>G	c.(823-825)TCA>TGA	p.S275*	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Nonsense_Mutation_p.S69*	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	275										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						AATCCTTCTTGAATCCTGAAA	0.318			NA											4	39					0	0	0.009096	0	0
FUBP1	8880	broad.mit.edu	37	1	78425923	78425923	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:78425923G>A	uc001dii.2	-	16	1611	c.1522C>T	c.(1522-1524)CAG>TAG	p.Q508*	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Nonsense_Mutation_p.Q529*	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	508	Pro-rich.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CCCCATCCCTGGGGAGCATAT	0.438			NA											11	62					0	0	0.008291	0	0
AMIGO1	57463	broad.mit.edu	37	1	110050444	110050444	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:110050444T>C	uc001dxx.3	-	2	1473	c.1091A>G	c.(1090-1092)CAC>CGC	p.H364R		NM_020703	NP_065754	Q86WK6	AMGO1_HUMAN	AMIGO protein precursor	364	Extracellular (Potential).				axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				ovary(1)|breast(1)	2		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		ATGGTGTCCGTGCAAGGTGAA	0.517			NA											7	49					0	0	0.00308	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882871	144882871	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:144882871G>T	uc001elw.3	-	24	3439	c.3148C>A	c.(3148-3150)CTG>ATG	p.L1050M	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.L1116M|PDE4DIP_uc001elv.3_Missense_Mutation_p.L57M	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1050					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CAAAGGCTCAGCATGGTGTTC	0.493			NA	T	PDGFRB	MPD								20	275					2.21704e-12	3.28539e-12	0.00278	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144915608	144915608	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:144915608C>A	uc001elw.3	-	14	2108	c.1817G>T	c.(1816-1818)GGA>GTA	p.G606V	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.G672V|PDE4DIP_uc001emc.1_Missense_Mutation_p.G606V|PDE4DIP_uc001emd.1_Missense_Mutation_p.G606V|PDE4DIP_uc001emb.1_Missense_Mutation_p.G769V|PDE4DIP_uc001eme.1_Missense_Mutation_p.G135V|PDE4DIP_uc001emf.1_Missense_Mutation_p.G391V	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	606	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGCCCTGGTCCAAGTTTGCA	0.468			NA	T	PDGFRB	MPD								20	107					8.04996e-18	1.26632e-17	0.001882	1	0
VPS45	11311	broad.mit.edu	37	1	150039930	150039930	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:150039930G>T	uc001etp.2	+	1	589	c.16G>T	c.(16-18)GCT>TCT	p.A6S	VPS45_uc010pbp.1_RNA|VPS45_uc010pbq.1_5'UTR|VPS45_uc010pbs.1_Intron|VPS45_uc009wlm.1_Missense_Mutation_p.A6S|VPS45_uc010pbr.1_Intron	NM_007259	NP_009190	Q9NRW7	VPS45_HUMAN	vacuolar protein sorting 45A	6					blood coagulation|intracellular protein transport|vesicle docking involved in exocytosis	endosome membrane|Golgi membrane|integral to membrane of membrane fraction				central_nervous_system(1)|skin(1)	2	Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CGTGGTTTTTGCTGTGAAGCA	0.498			NA											33	92					4.14481e-20	6.67412e-20	0.00623	1	0
FLG	2312	broad.mit.edu	37	1	152286898	152286898	+	Missense_Mutation	SNP	C	C	A	rs113297198		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:152286898C>A	uc001ezu.1	-	3	500	c.464G>T	c.(463-465)AGT>ATT	p.S155I	uc001ezv.2_Intron	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	155					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTTTTCAGAACTAGATTCATG	0.353			NA							Ichthyosis				26	150					5.45024e-15	8.31772e-15	0.00333	1	0
LCE1F	353137	broad.mit.edu	37	1	152748857	152748857	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:152748857C>A	uc010pdv.1	+	1	10	c.10C>A	c.(10-12)CAG>AAG	p.Q4K		NM_178354	NP_848131	Q5T754	LCE1F_HUMAN	late cornified envelope 1F	4					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATGTCTTGCCAGCAGAGCCA	0.368			NA											6	41					8.12818e-05	9.33828e-05	0.001984	1	0
RHBG	57127	broad.mit.edu	37	1	156354339	156354339	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:156354339T>G	uc010pho.1	+	9	1294	c.1256T>G	c.(1255-1257)TTT>TGT	p.F419C	RHBG_uc010phn.1_RNA|RHBG_uc001fos.2_Missense_Mutation_p.F350C|RHBG_uc009wrz.2_Missense_Mutation_p.F387C|RHBG_uc001for.2_Missense_Mutation_p.F389C	NM_020407	NP_065140	Q9H310	RHBG_HUMAN	Rhesus blood group, B glycoprotein	419	Interaction with ANK3.|Cytoplasmic (Potential).			F->A: Loss of interaction with ANK3. Intracellular retention; when associated with A-420 and A-421.	transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			ovary(2)	2	Hepatocellular(266;0.158)					AAGCTACCCTTTCTGGACTCC	0.627			NA									OREG0013871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	45					0	0	0.00245	0	0
ATP1A4	480	broad.mit.edu	37	1	160125911	160125911	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:160125911C>T	uc001fve.3	+	4	967	c.488C>T	c.(487-489)TCC>TTC	p.S163F	ATP1A4_uc001fvf.3_RNA	NM_144699	NP_653300	Q13733	AT1A4_HUMAN	Na+/K+ -ATPase alpha 4 subunit isoform 1	163	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(2)|skin(2)	4	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GCCAAGAGCTCCAAGATCATG	0.512			NA											14	72					0	0	0.003163	0	0
FCRLA	84824	broad.mit.edu	37	1	161680999	161680999	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:161680999C>A	uc001gbe.2	+	4	545	c.303C>A	c.(301-303)GAC>GAA	p.D101E	FCRLA_uc001gbd.2_Missense_Mutation_p.D95E|FCRLA_uc001gbf.2_Intron|FCRLA_uc001gbg.2_Intron|FCRLA_uc009wuo.2_Intron|FCRLA_uc009wup.2_Intron|FCRLA_uc009wuq.2_Intron	NM_032738	NP_116127	Q7L513	FCRLA_HUMAN	Fc receptor-like and mucin-like 1	78	Ig-like C2-type 1.				cell differentiation	cytoplasm|extracellular region					0	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GGACCATAGACTGGCTGATCC	0.592			NA											3	18					0.004672	0.00500222	0.004672	1	0
XCL2	6846	broad.mit.edu	37	1	168511287	168511287	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:168511287C>T	uc001gfn.3	-	2	153	c.120G>A	c.(118-120)CTG>CTA	p.L40L		NM_003175	NP_003166	Q9UBD3	XCL2_HUMAN	chemokine (C motif) ligand 2 precursor	40					blood circulation|chemotaxis|immune response|signal transduction	extracellular space	chemokine activity			ovary(1)	1	all_hematologic(923;0.215)					TGCTAACTGGCAGTCGCTGGG	0.483			NA											8	56					0	0	0.006214	0	0
XCL1	6375	broad.mit.edu	37	1	168549359	168549359	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:168549359G>A	uc001gfo.1	+	2	140	c.120G>A	c.(118-120)CTG>CTA	p.L40L		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	40					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					CCCAGCGACTGCCGGTTAGCA	0.473			NA											15	126					0	0	0.006122	0	0
KLHL20	27252	broad.mit.edu	37	1	173703228	173703228	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:173703228G>A	uc001gjc.2	+	3	579	c.400G>A	c.(400-402)GAA>AAA	p.E134K	KLHL20_uc010pmr.1_Intron|KLHL20_uc009wwf.2_Missense_Mutation_p.E116K|KLHL20_uc001gjd.2_Missense_Mutation_p.E134K	NM_014458	NP_055273	Q9Y2M5	KLH20_HUMAN	kelch-like 20	134	BTB.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			ovary(1)	1						GATAACAGTAGAAGAGGGCAA	0.473	GBM(159;862 2695 6559 23041)		NA											9	63					0	0	0.006214	0	0
TNR	7143	broad.mit.edu	37	1	175355420	175355420	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:175355420G>C	uc001gkp.1	-	6	1606	c.1525C>G	c.(1525-1527)CAG>GAG	p.Q509E	TNR_uc009wwu.1_Missense_Mutation_p.Q509E	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	509	Fibronectin type-III 3.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ACCAGGATCTGCGTGGGGCCG	0.443			NA											2	18					0	0	0.009096	0	0
TNR	7143	broad.mit.edu	37	1	175365934	175365934	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:175365934G>C	uc001gkp.1	-	3	1067	c.986C>G	c.(985-987)CCA>CGA	p.P329R	TNR_uc009wwu.1_Missense_Mutation_p.P329R|TNR_uc010pmz.1_Intron	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	329	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					CAAGTCCTCTGGAGGGGCAAC	0.557			NA											20	98					0	0	0.002096	0	0
FAM20B	9917	broad.mit.edu	37	1	179013192	179013192	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:179013192G>A	uc001gmc.2	+	2	503	c.210G>A	c.(208-210)TGG>TGA	p.W70*		NM_014864	NP_055679	O75063	XYLK_HUMAN	hypothetical protein LOC9917 precursor	70	Lumenal (Potential).					Golgi membrane|integral to membrane	ATP binding|kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(3)	3						CAGCCCAGTGGGTGGTTCCCC	0.562			NA											8	48					0	0	0.00308	0	0
FAM5C	339479	broad.mit.edu	37	1	190423887	190423887	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:190423887T>C	uc001gse.1	-	2	366	c.134A>G	c.(133-135)GAC>GGC	p.D45G	FAM5C_uc010pot.1_Missense_Mutation_p.T7A	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	45						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GAGGAGCCAGTCGAAGGGGCT	0.498			NA											5	25					0	0	0.000602	0	0
KCNT2	343450	broad.mit.edu	37	1	196227445	196227445	+	Silent	SNP	A	A	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:196227445A>C	uc001gtd.1	-	26	3150	c.3090T>G	c.(3088-3090)GGT>GGG	p.G1030G	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.G963G|KCNT2_uc001gtf.1_Silent_p.G1006G|KCNT2_uc001gtg.1_RNA|KCNT2_uc001gth.1_Silent_p.G534G	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1030	Cytoplasmic (Potential).|ATP (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						CAGCTGTTTTACCAGAGTGTT	0.473			NA											9	77					0	0	0.006214	0	0
ASPM	259266	broad.mit.edu	37	1	197059495	197059495	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:197059495C>A	uc001gtu.2	-	24	9917	c.9660G>T	c.(9658-9660)TGG>TGT	p.W3220C	ASPM_uc001gtv.2_Missense_Mutation_p.W1635C|ASPM_uc001gtw.3_Missense_Mutation_p.W1068C	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3220	IQ 39.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TTTTCTTCCTCCAAGAATAGC	0.303			NA											8	43					0.000157383	0.000177817	0.00308	1	0
ASPM	259266	broad.mit.edu	37	1	197112565	197112565	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:197112565C>A	uc001gtu.2	-	3	1074	c.817G>T	c.(817-819)GAG>TAG	p.E273*	ASPM_uc001gtv.2_Nonsense_Mutation_p.E273*|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	273					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						ACAGCTTTCTCATTAAAAGAA	0.363			NA											21	134					3.51602e-12	5.17284e-12	0.008871	1	0
CRB1	23418	broad.mit.edu	37	1	197390222	197390222	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:197390222C>T	uc001gtz.2	+	6	1399	c.1264C>T	c.(1264-1266)CAT>TAT	p.H422Y	CRB1_uc010poz.1_Missense_Mutation_p.H353Y|CRB1_uc010ppa.1_RNA|CRB1_uc009wza.2_Missense_Mutation_p.H310Y|CRB1_uc010ppb.1_Missense_Mutation_p.H422Y|CRB1_uc010ppc.1_RNA|CRB1_uc010ppd.1_5'UTR|CRB1_uc001gub.1_Missense_Mutation_p.H71Y	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	422	Extracellular (Potential).|EGF-like 10; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						TTATACTTGCCATTGCCCATT	0.413			NA											39	152					0	0	0.00623	0	0
KIF21B	23046	broad.mit.edu	37	1	200960801	200960801	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:200960801C>T	uc001gvs.1	-	17	2755	c.2438G>A	c.(2437-2439)AGG>AAG	p.R813K	KIF21B_uc001gvr.1_Missense_Mutation_p.R813K|KIF21B_uc009wzl.1_Missense_Mutation_p.R813K|KIF21B_uc010ppn.1_Missense_Mutation_p.R813K	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	813	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GGTCTTCCTCCTCAGGACCAT	0.607			NA											7	39					0	0	0.006214	0	0
KIF21B	23046	broad.mit.edu	37	1	200969654	200969654	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:200969654G>C	uc001gvs.1	-	11	1866	c.1549C>G	c.(1549-1551)CTG>GTG	p.L517V	KIF21B_uc001gvr.1_Missense_Mutation_p.L517V|KIF21B_uc009wzl.1_Missense_Mutation_p.L517V|KIF21B_uc010ppn.1_Missense_Mutation_p.L517V	NM_017596	NP_060066	O75037	KI21B_HUMAN	kinesin family member 21B	517	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)|skin(3)	6						GAAGCACCCAGGGAGTAGGGG	0.662			NA											10	89					0	0	0.008291	0	0
IGFN1	91156	broad.mit.edu	37	1	201187763	201187763	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:201187763C>A	uc001gwc.2	+	7	2127	c.1355C>A	c.(1354-1356)GCT>GAT	p.A452D	IGFN1_uc001gwb.2_RNA	NM_178275	NP_840059			RecName: Full=Immunoglobulin-like and fibronectin type III domain-containing protein 1; AltName: Full=EEF1A2-binding protein 1; AltName: Full=KY-interacting protein 1;											ovary(2)|pancreas(1)	3						CCATCGGATGCTGTCTTTGCT	0.627			NA											8	26					7.48243e-07	9.50408e-07	0.006214	1	0
CR2	1380	broad.mit.edu	37	1	207649641	207649641	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:207649641G>T	uc001hfw.2	+	14	2696	c.2602G>T	c.(2602-2604)GCT>TCT	p.A868S	CR2_uc001hfv.2_Missense_Mutation_p.A927S|CR2_uc009xch.2_Intron	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	868	Sushi 14.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						TGGAAACATAGCTCGATTTTC	0.507			NA											4	79					0.00909568	0.00963765	0.009096	1	0
PLXNA2	5362	broad.mit.edu	37	1	208270154	208270154	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:208270154C>A	uc001hgz.2	-	7	2564	c.1806G>T	c.(1804-1806)GTG>GTT	p.V602V		NM_025179	NP_079455	O75051	PLXA2_HUMAN	plexin A2 precursor	602	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane				ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(81;0.199)		CCTGCCCCTCCACCTCTGTCA	0.562			NA											10	37					7.48243e-07	9.50408e-07	0.006214	1	0
TATDN3	128387	broad.mit.edu	37	1	212976051	212976051	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:212976051T>A	uc001hjo.2	+	5	361	c.267T>A	c.(265-267)GAT>GAA	p.D89E	TATDN3_uc010ptj.1_Missense_Mutation_p.D89E|TATDN3_uc010ptk.1_Missense_Mutation_p.D89E|TATDN3_uc001hjp.2_Missense_Mutation_p.D89E|TATDN3_uc010ptl.1_Intron|TATDN3_uc010ptm.1_Missense_Mutation_p.D37E	NM_001042552	NP_001036017	Q17R31	TATD3_HUMAN	TatD DNase domain containing 3 isoform 1	89						nucleus	endodeoxyribonuclease activity, producing 5'-phosphomonoesters|metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00699)|all cancers(67;0.0118)|GBM - Glioblastoma multiforme(131;0.0801)|Epithelial(68;0.104)		AGGATTTGGATGTAGCTTTGC	0.264			NA											14	86					0	0	0.003163	0	0
SUSD4	55061	broad.mit.edu	37	1	223465926	223465926	+	Silent	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:223465926T>C	uc001hnx.2	-	2	850	c.216A>G	c.(214-216)GGA>GGG	p.G72G	SUSD4_uc001hny.3_Silent_p.G72G|SUSD4_uc010puw.1_5'UTR|SUSD4_uc001hnz.2_Silent_p.G72G|SUSD4_uc010pux.1_Intron	NM_017982	NP_060452	Q5VX71	SUSD4_HUMAN	sushi domain containing 4 isoform a	72	Sushi 1.|Extracellular (Potential).					integral to membrane					0				GBM - Glioblastoma multiforme(131;0.0611)		AGAAAACCCCTCCGCTGGGGG	0.502			NA											10	81					0	0	0.001368	0	0
C1orf69	200205	broad.mit.edu	37	1	228362874	228362874	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:228362874A>T	uc001hsl.3	+	3	820	c.731A>T	c.(730-732)GAG>GTG	p.E244V	C1orf69_uc010pvw.1_Missense_Mutation_p.E51V	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	244					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				CTGCCCCTGGAGTCCAACCTG	0.632			NA											10	85					0	0	0.008291	0	0
RHOU	58480	broad.mit.edu	37	1	228879403	228879403	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:228879403G>T	uc001htf.2	+	3	1314	c.693G>T	c.(691-693)CAG>CAT	p.Q231H		NM_021205	NP_067028	Q7L0Q8	RHOU_HUMAN	ras homolog gene family, member U	231					regulation of small GTPase mediated signal transduction	cell projection|cytosol|focal adhesion|Golgi membrane|podosome	GTP binding|metal ion binding|protein binding				0	Breast(184;0.162)	Prostate(94;0.183)				CTCAGCAACAGCCAAAGAAGT	0.468			NA											18	107					1.33834e-09	1.8246e-09	0.007413	1	0
RYR2	6262	broad.mit.edu	37	1	237813179	237813179	+	Silent	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:237813179A>G	uc001hyl.1	+	50	7635	c.7515A>G	c.(7513-7515)GCA>GCG	p.A2505A		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2505	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTTTCAGGCAGCTTTGAGTG	0.458			NA											11	102					0	0	0.000978	0	0
RYR2	6262	broad.mit.edu	37	1	237921011	237921011	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:237921011A>T	uc001hyl.1	+	82	11380	c.11260A>T	c.(11260-11262)ATG>TTG	p.M3754L	RYR2_uc010pya.1_Missense_Mutation_p.M169L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3754					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AACTGGACCAATGGTAGCAGC	0.353			NA											16	82					0	0	0.00499	0	0
OR2T12	127064	broad.mit.edu	37	1	248458341	248458341	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:248458341G>A	uc010pzj.1	-	1	540	c.540C>T	c.(538-540)CCC>CCT	p.P180P		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GCACCAACACGGGGGCCTCGC	0.562			NA											15	63					0	0	0.00499	0	0
OR2T12	127064	broad.mit.edu	37	1	248458344	248458344	+	Silent	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:248458344G>C	uc010pzj.1	-	1	537	c.537C>G	c.(535-537)GCC>GCG	p.A179A		NM_001004692	NP_001004692	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T,	179	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CCAACACGGGGGCCTCGCAGA	0.567			NA											13	60					0	0	0.003163	0	0
OR2M7	391196	broad.mit.edu	37	1	248487249	248487249	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:248487249C>T	uc010pzk.1	-	1	622	c.622G>A	c.(622-624)GTT>ATT	p.V208I		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGGGAAAACAAGCATTACT	0.428			NA											96	325					0	0	0.00361	0	0
OR2M7	391196	broad.mit.edu	37	1	248487840	248487840	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:248487840C>T	uc010pzk.1	-	1	31	c.31G>A	c.(31-33)GAC>AAC	p.D11N		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	11	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGAGGAAGTCAGAGTTGAAG	0.458			NA											30	186					0	0	0.003271	0	0
MYO3A	53904	broad.mit.edu	37	10	26462618	26462618	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:26462618A>T	uc001isn.2	+	30	3785	c.3425A>T	c.(3424-3426)GAA>GTA	p.E1142V	MYO3A_uc009xkp.1_Intron|MYO3A_uc009xkq.1_Intron	NM_017433	NP_059129	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1142					protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			ovary(6)|stomach(3)|lung(3)|central_nervous_system(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	18						AAACAAGCAGAAAATGCAATC	0.328			NA											4	38					0	0	0.009096	0	0
LRRC18	474354	broad.mit.edu	37	10	50121502	50121502	+	Silent	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:50121502T>C	uc001jhd.2	-	1	779	c.699A>G	c.(697-699)AGA>AGG	p.R233R	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Silent_p.R233R	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	233						cytoplasm				ovary(1)|pancreas(1)	2						AGATGGTCTTTCTCGGTGTCG	0.522			NA											25	192					0	0	0.003954	0	0
ERCC6	2074	broad.mit.edu	37	10	50679090	50679090	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:50679090G>T	uc001jhs.3	-	17	3155	c.3001C>A	c.(3001-3003)CTC>ATC	p.L1001I	ERCC6_uc009xod.2_Missense_Mutation_p.L161I|ERCC6_uc010qgr.1_Missense_Mutation_p.L371I|ERCC6_uc001jhr.3_Missense_Mutation_p.L369I	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1001	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						AGCTCATAGAGATCATTGGAT	0.328			NA						Direct_reversal_of_damage|NER					13	187					2.31682e-05	2.75459e-05	0.003163	1	0
ZWINT	11130	broad.mit.edu	37	10	58119843	58119843	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:58119843C>A	uc001jjx.1	-	3	229	c.192G>T	c.(190-192)CAG>CAT	p.Q64H	ZWINT_uc001jjy.1_Missense_Mutation_p.Q64H|ZWINT_uc001jka.1_Missense_Mutation_p.Q64H|ZWINT_uc009xoy.1_Intron	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	64					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						CCAGGATGTTCTGCAGGAAAT	0.562			NA											12	47					4.84862e-15	7.42728e-15	0.000978	1	0
JMJD1C	221037	broad.mit.edu	37	10	64967523	64967523	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:64967523C>A	uc001jmn.2	-	10	4206	c.3906G>T	c.(3904-3906)ATG>ATT	p.M1302I	JMJD1C_uc001jml.2_Missense_Mutation_p.M1083I|JMJD1C_uc001jmm.2_Missense_Mutation_p.M1014I|JMJD1C_uc010qiq.1_Missense_Mutation_p.M1120I|JMJD1C_uc009xpi.2_Missense_Mutation_p.M1120I|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.M339I	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1302					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					TGACAGATGCCATAGCAGCCT	0.423			NA											35	151					1.42033e-22	2.333e-22	0.004289	1	0
VCL	7414	broad.mit.edu	37	10	75874084	75874084	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:75874084G>T	uc001jwd.2	+	20	3186	c.3092G>T	c.(3091-3093)CGG>CTG	p.R1031L	VCL_uc009xrr.2_Missense_Mutation_p.R712L|VCL_uc010qky.1_Missense_Mutation_p.R938L|VCL_uc001jwe.2_Missense_Mutation_p.R963L|VCL_uc010qkz.1_Missense_Mutation_p.R224L	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	1031	C-terminal tail.|Facilitates phospholipid membrane insertion (By similarity).				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					GAGGTGACTCGGTTGGCCAAG	0.498			NA											8	42					1.12685e-05	1.35554e-05	0.004482	1	0
SH2D4B	387694	broad.mit.edu	37	10	82369203	82369203	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:82369203G>T	uc001kck.1	+	6	1311	c.881G>T	c.(880-882)CGC>CTC	p.R294L	SH2D4B_uc001kcl.1_Missense_Mutation_p.R246L|SH2D4B_uc001kcm.1_Missense_Mutation_p.R41L	NM_207372	NP_997255	Q5SQS7	SH24B_HUMAN	SH2 domain containing 4B isoform 1	293											0			Colorectal(32;0.229)			CGCCCGCTGCGCCCAGTCTCC	0.542			NA											4	61					2.56e-06	3.1922e-06	0.009096	1	0
FAM190B	54462	broad.mit.edu	37	10	86259667	86259667	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:86259667G>T	uc001kdh.1	+	10	2556	c.2362G>T	c.(2362-2364)GGC>TGC	p.G788C	FAM190B_uc010qmd.1_Intron|FAM190B_uc001kdi.1_Intron|FAM190B_uc010qme.1_Missense_Mutation_p.G215C	NM_018999	NP_061872	Q9H7U1	F190B_HUMAN	granule cell antiserum positive 14	788										ovary(3)|skin(1)	4						TCCTTGGCAGGGCTCCTTCCA	0.527			NA											8	85					3.09899e-07	3.99838e-07	0.004482	1	0
PLCE1	51196	broad.mit.edu	37	10	95892185	95892185	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:95892185T>A	uc001kjk.2	+	3	2095	c.1461T>A	c.(1459-1461)TTT>TTA	p.F487L	PLCE1_uc010qnx.1_Missense_Mutation_p.F487L|PLCE1_uc001kjm.2_Missense_Mutation_p.F179L	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	487					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TCAGTACTTTTGGAGGATCCA	0.433			NA											19	107					0	0	0.010504	0	0
CNNM1	26507	broad.mit.edu	37	10	101090479	101090479	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:101090479C>T	uc001kpp.3	+	1	1624	c.1335C>T	c.(1333-1335)GAC>GAT	p.D445D	CNNM1_uc009xwe.2_Silent_p.D445D|CNNM1_uc010qpi.1_Silent_p.D445D|CNNM1_uc009xwf.2_Silent_p.D445D	NM_020348	NP_065081	Q9NRU3	CNNM1_HUMAN	cyclin M1	445	CBS 1.				ion transport	integral to membrane|plasma membrane					0		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		TGCGCTCAGACGCGGTGCTCG	0.602			NA											5	35					0	0	0.001168	0	0
WNT8B	7479	broad.mit.edu	37	10	102242208	102242208	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:102242208C>T	uc001krb.2	+	6	805	c.691C>T	c.(691-693)CGC>TGC	p.R231C		NM_003393	NP_003384	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family,	231					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			ovary(1)|breast(1)|large_intestine(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		CGCGGCCGGCCGCGGCGCCAT	0.667			NA									OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	24					0	0	0.009096	0	0
NEURL	9148	broad.mit.edu	37	10	105330655	105330655	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:105330655A>G	uc001kxh.2	+	2	522	c.112A>G	c.(112-114)ACT>GCT	p.T38A		NM_004210	NP_004201	O76050	NEU1A_HUMAN	neuralized-like	38					nervous system development	perinuclear region of cytoplasm	zinc ion binding				0				Epithelial(162;2.12e-09)|all cancers(201;6.99e-08)|BRCA - Breast invasive adenocarcinoma(275;0.125)		CTTCCCCGTCACTTCTCACCG	0.652			NA											48	234					0	0	0.00361	0	0
VAX1	11023	broad.mit.edu	37	10	118896116	118896116	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:118896116C>A	uc009xyx.2	-	2	541	c.296G>T	c.(295-297)CGG>CTG	p.R99L	VAX1_uc001ldb.1_Missense_Mutation_p.R99L	NM_001112704	NP_001106175	Q5SQQ9	VAX1_HUMAN	ventral anterior homeobox 1 isoform a	99						nucleus	sequence-specific DNA binding			ovary(2)	2				all cancers(201;0.0108)		CCTCTTAGGCCGGTCCAAGTC	0.657			NA											10	22					0.00621372	0.00661825	0.006214	1	0
CPXM2	119587	broad.mit.edu	37	10	125521558	125521558	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:125521558G>A	uc001lhk.1	-	11	1932	c.1607C>T	c.(1606-1608)ACG>ATG	p.T536M	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	536					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GTGTTCCTGCGTCTTCCAGGG	0.657			NA											10	74					0	0	0.000978	0	0
LOC338651	338651	broad.mit.edu	37	11	1618918	1618918	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:1618918G>T	uc009ycx.1	+	2	769	c.18G>T	c.(16-18)AGG>AGT	p.R6S	LOC338651_uc001ltt.1_RNA|KRTAP5-2_uc001ltv.2_3'UTR	NR_021489				SubName: Full=cDNA FLJ30579 fis, clone BRAWH2006989, weakly similar to DNA-DIRECTED RNA POLYMERASE II LARGEST SUBUNIT;          EC=2.7.7.6;												0						CACCAAACAGGAGAAACCTGA	0.547			NA											6	50					0.00198382	0.00214651	0.001984	1	0
KRTAP5-5	439915	broad.mit.edu	37	11	1651183	1651183	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:1651183G>T	uc001lty.2	+	1	151	c.113G>T	c.(112-114)TGT>TTT	p.C38F		NM_001001480	NP_001001480	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	38						keratin filament				lung(1)	1		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		tgtgggggctgtggctccggc	0.09			NA											4	25					1.23904e-05	1.48612e-05	0.000602	1	0
OSBPL5	114879	broad.mit.edu	37	11	3121425	3121425	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:3121425C>T	uc001lxk.2	-	14	1742	c.1584G>A	c.(1582-1584)GAG>GAA	p.E528E	OSBPL5_uc010qxq.1_Silent_p.E439E|OSBPL5_uc009ydw.2_Silent_p.E460E|OSBPL5_uc001lxl.2_Silent_p.E460E|OSBPL5_uc009ydx.2_Silent_p.E552E	NM_020896	NP_065947	Q9H0X9	OSBL5_HUMAN	oxysterol-binding protein-like protein 5 isoform	528					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			large_intestine(2)|central_nervous_system(1)	3		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		GGGTGTAATCCTCGGCTCGGT	0.607			NA											3	18					0	0	0.009096	0	0
TEAD1	7003	broad.mit.edu	37	11	12886397	12886397	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:12886397A>G	uc001mkj.3	+	5	900	c.235A>G	c.(235-237)ATT>GTT	p.I79V	TEAD1_uc009ygk.2_RNA	NM_021961	NP_068780	P28347	TEAD1_HUMAN	TEA domain family member 1	94	TEA.				hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0				Epithelial(150;0.00223)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GTCTAGTCACATTCAGGTTCT	0.473			NA											25	110					0	0	0.007291	0	0
DGKZ	8525	broad.mit.edu	37	11	46389247	46389247	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:46389247T>G	uc001ncn.1	+	4	1008	c.883T>G	c.(883-885)TCC>GCC	p.S295A	DGKZ_uc001nch.1_Missense_Mutation_p.S123A|DGKZ_uc010rgq.1_Missense_Mutation_p.S72A|DGKZ_uc001ncj.1_Missense_Mutation_p.S72A|DGKZ_uc010rgr.1_Missense_Mutation_p.S71A|DGKZ_uc001nck.1_5'UTR|DGKZ_uc001ncl.2_Missense_Mutation_p.S106A|DGKZ_uc001ncm.2_Missense_Mutation_p.S106A|DGKZ_uc009yky.1_Missense_Mutation_p.S106A|DGKZ_uc010rgs.1_Missense_Mutation_p.S106A|DGKZ_uc001nci.1_Missense_Mutation_p.S72A	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	295	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		GACCAACGTGTCCGGGGACTT	0.647			NA									OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	30					0	0	0.001984	0	0
LOC440040	440040	broad.mit.edu	37	11	49598269	49598269	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:49598269G>A	uc010rhy.1	+	2	860	c.382G>A	c.(382-384)GTC>ATC	p.V128I	LOC440040_uc009ymb.2_Missense_Mutation_p.V128I	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						AGCCATTCAGGTCCAGAATTT	0.488			NA											6	18					0	0	0.00308	0	0
OR4A16	81327	broad.mit.edu	37	11	55111517	55111517	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:55111517A>G	uc010rie.1	+	1	841	c.841A>G	c.(841-843)AAT>GAT	p.N281D		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	281	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						ACTCATGTTGAATCCTTTAAT	0.318			NA											12	62					0	0	0.000978	0	0
OR8H1	219469	broad.mit.edu	37	11	56057612	56057612	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:56057612G>T	uc010rje.1	-	1	927	c.927C>A	c.(925-927)GAC>GAA	p.D309E		NM_001005199	NP_001005199	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3	Esophageal squamous(21;0.00448)					ATTACCTGGAGTCCTGTCTTC	0.328			NA											22	162					3.83957e-06	4.71587e-06	0.00278	1	0
OR5M8	219484	broad.mit.edu	37	11	56258326	56258326	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:56258326T>A	uc001nix.1	-	1	521	c.521A>T	c.(520-522)AAT>ATT	p.N174I		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GTAGAAGTGATTAATTTCATT	0.493			NA											14	64					0	0	0.00245	0	0
OR4D6	219983	broad.mit.edu	37	11	59225048	59225048	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:59225048G>T	uc010rku.1	+	1	615	c.615G>T	c.(613-615)CTG>CTT	p.L205L		NM_001004708	NP_001004708	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ACAACGGACTGGTGACCCTGC	0.542			NA											28	63					4.87955e-14	7.36435e-14	0.005443	1	0
MS4A1	931	broad.mit.edu	37	11	60235910	60235910	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:60235910C>A	uc001npp.2	+	8	1279	c.863C>A	c.(862-864)TCC>TAC	p.S288Y	MS4A1_uc001npq.2_Missense_Mutation_p.S288Y|MS4A1_uc009yna.2_Missense_Mutation_p.S288Y|MS4A1_uc009ymz.2_Missense_Mutation_p.S275Y|MS4A1_uc010rlc.1_Missense_Mutation_p.S121Y	NM_152866	NP_690605	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member	288	Cytoplasmic (Potential).				B cell activation|immune response	integral to plasma membrane				ovary(3)|lung(2)	5					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	GATCAGGAATCCTCACCAATA	0.378			NA											4	68					3.59834e-05	4.26585e-05	0.001168	1	0
C11orf9	745	broad.mit.edu	37	11	61541490	61541490	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:61541490G>T	uc001nsc.1	+	8	1263	c.1167G>T	c.(1165-1167)GTG>GTT	p.V389V	C11orf9_uc001nse.1_Silent_p.V380V	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	389	NDT80.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						ACTTTTCGGTGGGCGACGACG	0.652			NA											6	28					0.00116845	0.00128122	0.001168	1	0
HNRNPUL2	221092	broad.mit.edu	37	11	62488849	62488849	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:62488849A>T	uc001nuw.2	-	9	1722	c.1529T>A	c.(1528-1530)CTT>CAT	p.L510H	HNRNPUL2_uc001nuu.1_RNA	NM_001079559	NP_001073027	Q1KMD3	HNRL2_HUMAN	heterogeneous nuclear ribonucleoprotein U-like	510					cell killing	nucleus	ATP binding|nucleic acid binding				0						CTGAACTAAAAGGTCTCGGCT	0.413			NA											27	291					0	0	0.002445	0	0
ATG2A	23130	broad.mit.edu	37	11	64678617	64678617	+	Silent	SNP	C	C	A	rs151243555		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:64678617C>A	uc001obx.2	-	10	1474	c.1359G>T	c.(1357-1359)ACG>ACT	p.T453T		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	453							protein binding			ovary(1)|central_nervous_system(1)	2						TGAAAAAGTGCGTGGCGAGGT	0.607			NA											4	52					0.00024832	0.000279019	0.009096	1	0
MMP27	64066	broad.mit.edu	37	11	102565698	102565698	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:102565698C>T	uc001phd.1	-	7	1056	c.1033G>A	c.(1033-1035)GAT>AAT	p.D345N		NM_022122	NP_071405	Q9H306	MMP27_HUMAN	matrix metalloproteinase 27 precursor	345	Hemopexin-like 2.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3	all_cancers(8;0.000843)|all_epithelial(12;0.00362)|Lung NSC(15;0.21)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0509)|Lung(13;0.0696)|LUSC - Lung squamous cell carcinoma(19;0.13)|all cancers(10;0.176)	BRCA - Breast invasive adenocarcinoma(274;0.0151)		GCCAGGTTACCTTTAAAAACC	0.448			NA											15	23					0	0	0.004007	0	0
DDI1	414301	broad.mit.edu	37	11	103907640	103907640	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:103907640C>A	uc001phr.2	+	1	333	c.90C>A	c.(88-90)TTC>TTA	p.F30L	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	30	Ubiquitin-like.				proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TCCGAAACTTCAAGGTCCTCT	0.557			NA											36	95					3.09479e-21	5.02289e-21	0.006999	1	0
CADM1	23705	broad.mit.edu	37	11	115080337	115080337	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:115080337G>A	uc001ppi.3	-	8	1164	c.1035C>T	c.(1033-1035)ACC>ACT	p.T345T	CADM1_uc001ppf.3_Intron|CADM1_uc001ppk.3_Intron|CADM1_uc001ppj.3_Intron|CADM1_uc001pph.3_Silent_p.T97T	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	345	Extracellular (Potential).			PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggtggtggttg	0.269			NA											5	44					0	0	0.000602	0	0
OAF	220323	broad.mit.edu	37	11	120097542	120097542	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:120097542G>A	uc001pxb.2	+	3	625	c.384G>A	c.(382-384)GTG>GTA	p.V128V		NM_178507	NP_848602	Q86UD1	OAF_HUMAN	OAF homolog precursor	128											0		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)		CCCGGGCAGTGCGGCAGGCGG	0.607			NA											6	54					0	0	0.004482	0	0
OR10G9	219870	broad.mit.edu	37	11	123894188	123894188	+	Missense_Mutation	SNP	G	G	T	rs144713433		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:123894188G>T	uc010sad.1	+	1	469	c.469G>T	c.(469-471)GTC>TTC	p.V157F		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	157	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GCACTCTGCTGTCCAGACCAT	0.557			NA											64	93					5.00163e-47	8.45317e-47	0.00361	1	0
CCDC15	80071	broad.mit.edu	37	11	124857203	124857203	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:124857203C>T	uc001qbm.3	+	8	1340	c.1081C>T	c.(1081-1083)CAG>TAG	p.Q361*		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	361						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		GCCAGATACCCAGGCTGTTGA	0.473			NA											43	101					0	0	0.002522	0	0
ST14	6768	broad.mit.edu	37	11	130064043	130064043	+	Splice_Site	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr11:130064043G>T	uc001qfw.2	+	8	1069	c.876_splice	c.e8-1	p.Q292_splice	ST14_uc010sca.1_Splice_Site_p.Q102_splice	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase						proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	TGCCCCCACAGGTTGTGTGGC	0.602			NA											11	93					6.40141e-05	7.48051e-05	0.000978	1	0
GALNT8	26290	broad.mit.edu	37	12	4873146	4873146	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:4873146G>C	uc001qne.1	+	9	1618	c.1526G>C	c.(1525-1527)TGC>TCC	p.C509S		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	509	Ricin B-type lectin.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						GAAAATGTCTGCTTGGATCAG	0.512	Colon(108;631 1558 7270 20097 39846)		NA											7	51					0	0	0.00308	0	0
SLC2A14	144195	broad.mit.edu	37	12	7967074	7967074	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:7967074C>A	uc001qtk.2	-	16	2194	c.1401G>T	c.(1399-1401)TTG>TTT	p.L467F	SLC2A14_uc001qtl.2_Missense_Mutation_p.L444F|SLC2A14_uc001qtm.2_Missense_Mutation_p.L444F|SLC2A14_uc010sgg.1_Missense_Mutation_p.L358F|SLC2A14_uc001qtn.2_Missense_Mutation_p.L467F|SLC2A14_uc001qto.2_Missense_Mutation_p.L102F|SLC2A14_uc010sgh.1_Missense_Mutation_p.L482F	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	467	Helical; Name=12; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		AGGTAAAGGCCAAGAAGGTAA	0.453			NA											11	55					3.86212e-05	4.55218e-05	0.008291	1	0
ZNF705A	440077	broad.mit.edu	37	12	8329650	8329650	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:8329650G>A	uc001qud.1	+	5	446	c.374G>A	c.(373-375)TGC>TAC	p.C125Y		NM_001004328	NP_001004328	Q6ZN79	Z705A_HUMAN	zinc finger protein 705A	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				Kidney(36;0.0877)		GGAGAAGATTGCACTCACAGT	0.393			NA											28	118					0	0	0.002445	0	0
GRIN2B	2904	broad.mit.edu	37	12	13768141	13768141	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:13768141C>T	uc001rbt.2	-	7	1740	c.1561G>A	c.(1561-1563)GAG>AAG	p.E521K		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	521	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCGACCACCTCCGATCGTTCC	0.502			NA											6	57					0	0	0.001984	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21033901	21033901	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:21033901C>T	uc001rek.2	+	11	1570	c.1444C>T	c.(1444-1446)CTG>TTG	p.L482L	SLCO1B3_uc001rel.2_Silent_p.L482L|SLCO1B3_uc010sil.1_Silent_p.L482L|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Silent_p.L307L	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	482	Extracellular (Potential).|Kazal-like.				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					AATAACTTACCTGTCACCTTG	0.393			NA											20	122					0	0	0.00278	0	0
ABCC9	10060	broad.mit.edu	37	12	21998656	21998656	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:21998656G>T	uc001rfi.1	-	24	2997	c.2977C>A	c.(2977-2979)CTG>ATG	p.L993M	ABCC9_uc001rfh.2_Missense_Mutation_p.L993M|ABCC9_uc001rfj.1_Missense_Mutation_p.L957M	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	993	Helical; Name=12; (Potential).				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AGGATGAGCAGGAAGAATCCT	0.448			NA											15	55					1.05317e-09	1.45523e-09	0.00245	1	0
OR10A7	121364	broad.mit.edu	37	12	55615682	55615682	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:55615682C>A	uc010spf.1	+	1	874	c.874C>A	c.(874-876)CTG>ATG	p.L292M		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						CATCTACGGCCTGAGGAACAA	0.448			NA											7	54					2.17888e-05	2.59814e-05	0.006214	1	0
OR6C70	390327	broad.mit.edu	37	12	55863608	55863608	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:55863608C>A	uc010spn.1	-	1	315	c.315G>T	c.(313-315)TTG>TTT	p.L105F		NM_001005499	NP_001005499	A6NIJ9	O6C70_HUMAN	olfactory receptor, family 6, subfamily C,	105	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CTGTAACCCCCAAGAATATGT	0.393			NA											11	60					1.36491e-13	2.04487e-13	0.001855	1	0
LRP1	4035	broad.mit.edu	37	12	57595378	57595378	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:57595378G>A	uc001snd.2	+	66	10910	c.10444G>A	c.(10444-10446)GGC>AGC	p.G3482S		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3482	Extracellular (Potential).|LDL-receptor class A 24.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTGTGTGGATGGCAGTGATGA	0.642			NA											6	37					0	0	0.001168	0	0
MON2	23041	broad.mit.edu	37	12	62981934	62981934	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:62981934A>G	uc001sre.2	+	34	5379	c.4988A>G	c.(4987-4989)AAT>AGT	p.N1663S	MON2_uc009zqj.2_Missense_Mutation_p.N1663S|MON2_uc010ssl.1_Missense_Mutation_p.N1591S|MON2_uc010ssm.1_Missense_Mutation_p.N1634S|MON2_uc010ssn.1_Missense_Mutation_p.N1657S|MON2_uc001srf.2_Missense_Mutation_p.N1426S|MON2_uc001srg.2_Missense_Mutation_p.N532S	NM_015026	NP_055841	Q7Z3U7	MON2_HUMAN	MON2 homolog	1664					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CAGCCTGAGAATGGTAAGTGC	0.299			NA											7	16					0	0	0.006214	0	0
POC1B	282809	broad.mit.edu	37	12	89860637	89860637	+	Silent	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:89860637G>C	uc001tbc.2	-	9	1047	c.942C>G	c.(940-942)CTC>CTG	p.L314L	POC1B_uc001tba.2_Silent_p.L272L|POC1B_uc001tbb.2_Silent_p.L184L|POC1B_uc010sun.1_RNA|POC1B_uc009zsp.2_RNA|POC1B_uc009zsq.2_RNA	NM_172240	NP_758440	Q8TC44	POC1B_HUMAN	WD repeat domain 51B	314					cell projection organization	centriole|microtubule basal body				ovary(1)	1						GTAATCTTTTGAGATTTCTTT	0.348			NA											21	74					0	0	0.008871	0	0
DNAH10	196385	broad.mit.edu	37	12	124298029	124298029	+	Missense_Mutation	SNP	C	C	T	rs138397621	byFrequency	TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:124298029C>T	uc001uft.3	+	19	3134	c.3109C>T	c.(3109-3111)CGC>TGC	p.R1037C	DNAH10_uc010tav.1_Missense_Mutation_p.R579C|DNAH10_uc010taw.1_Missense_Mutation_p.R522C	NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1037	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGAGGTTATGCGCCACCCTCT	0.443			NA											3	68					0	0	0.004672	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138770	126138770	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:126138770C>G	uc001uhe.1	+	9	2759	c.2751C>G	c.(2749-2751)ATC>ATG	p.I917M	TMEM132B_uc001uhf.1_Missense_Mutation_p.I429M	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	917	Helical; (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TCTTCTTGATCAACTGCGTGG	0.532			NA											11	64					0	0	0.001368	0	0
EP400	57634	broad.mit.edu	37	12	132498101	132498101	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:132498101G>T	uc001ujn.2	+	17	3713	c.3678G>T	c.(3676-3678)GTG>GTT	p.V1226V	EP400_uc001ujl.2_Silent_p.V1225V|EP400_uc001ujm.2_Silent_p.V1226V	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	1262	Interactions with RUVBL1 and RUVBL2.|Helicase ATP-binding.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGACCATGGTGCACTTCCTGG	0.552			NA											17	63					2.35188e-11	3.39901e-11	0.006122	1	0
EP400	57634	broad.mit.edu	37	12	132539519	132539519	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr12:132539519G>C	uc001ujn.2	+	43	7764	c.7729G>C	c.(7729-7731)GCA>CCA	p.A2577P	EP400_uc001ujl.2_Missense_Mutation_p.A2576P|EP400_uc001ujm.2_Missense_Mutation_p.A2496P	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2613	Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TTTTAAATAGGCAGGAACCAT	0.264			NA											5	45					0	0	0.001984	0	0
IFT88	8100	broad.mit.edu	37	13	21166510	21166510	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr13:21166510C>T	uc001unh.2	+	9	788	c.392C>T	c.(391-393)CCT>CTT	p.P131L	IFT88_uc001uni.2_Missense_Mutation_p.P122L|IFT88_uc001unj.2_Missense_Mutation_p.P121L|IFT88_uc010tcq.1_Missense_Mutation_p.P102L	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	131					cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TCAAGGGGCCCTGCTTCCCCT	0.353			NA											21	57					0	0	0.00278	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33018246	33018246	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr13:33018246T>A	uc010abe.1	-	7	450	c.428A>T	c.(427-429)AAA>ATA	p.K143I	N4BP2L2_uc001uug.2_Missense_Mutation_p.K26I|N4BP2L2_uc010abd.1_Missense_Mutation_p.K56I|N4BP2L2_uc001uuh.2_5'UTR|N4BP2L2_uc001uuj.2_Intron|N4BP2L2_uc010tdz.1_Missense_Mutation_p.K128I	NM_033111	NP_149102	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	Error:Variant_position_missing_in_Q92802_after_alignment											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ATGCCCAGTTTTCTTCAAAAC	0.313			NA											6	33					0	0	0.001168	0	0
SETDB2	83852	broad.mit.edu	37	13	50042023	50042023	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr13:50042023G>C	uc001vcz.2	+	6	1174	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	SETDB2_uc010adg.2_Missense_Mutation_p.E66Q|SETDB2_uc001vcy.3_Missense_Mutation_p.E78Q|SETDB2_uc010adh.2_Missense_Mutation_p.E78Q|SETDB2_uc001vda.2_Missense_Mutation_p.E78Q	NM_031915	NP_114121	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2 isoform a	90					cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		GACTCAGAAGGAACAGGAAAA	0.323			NA											6	46					0	0	0.001168	0	0
PCDH17	27253	broad.mit.edu	37	13	58240807	58240807	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr13:58240807T>A	uc001vhq.1	+	3	3529	c.2637T>A	c.(2635-2637)TTT>TTA	p.F879L	PCDH17_uc010aec.1_Missense_Mutation_p.F878L|PCDH17_uc001vhr.1_5'UTR	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	879	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCTCCACGTTTAAGGACCCAG	0.443	Melanoma(72;952 1291 1619 12849 33676)		NA											12	29					0	0	0.001855	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454106	84454106	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr13:84454106C>T	uc001vlk.2	-	1	2423	c.1537G>A	c.(1537-1539)GGG>AGG	p.G513R		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	513	Extracellular (Potential).|LRR 12.					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TCCAGCACCCCTGCCACCGGG	0.562			NA											8	43					0	0	0.004482	0	0
DNAJC3	5611	broad.mit.edu	37	13	96443247	96443247	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr13:96443247C>T	uc001vmq.2	+	12	1586	c.1478C>T	c.(1477-1479)TCA>TTA	p.S493L	DNAJC3_uc001vmr.2_Missense_Mutation_p.S442L	NM_006260	NP_006251	Q13217	DNJC3_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 3	493					protein folding|response to unfolded protein|response to virus		heat shock protein binding|protein kinase inhibitor activity|unfolded protein binding				0	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.126)			CCCTTCAGCTCAGGCGGACCA	0.428			NA											12	91					0	0	0.001855	0	0
OR4N5	390437	broad.mit.edu	37	14	20612416	20612416	+	Silent	SNP	C	C	A	rs76001619	byFrequency	TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:20612416C>A	uc010tla.1	+	1	522	c.522C>A	c.(520-522)CTC>CTA	p.L174L		NM_001004724	NP_001004724	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CAAACCAGCTCGATAACTTCT	0.507			NA											13	86					1.5842e-08	2.11744e-08	0.001855	1	0
LRFN5	145581	broad.mit.edu	37	14	42356586	42356586	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:42356586G>A	uc001wvm.2	+	3	1956	c.758G>A	c.(757-759)CGT>CAT	p.R253H	LRFN5_uc010ana.2_Missense_Mutation_p.R253H	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	253	Extracellular (Potential).|LRRCT.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TGGTTGAGGCGTCTGTCCAGA	0.443			NA								HNSCC(30;0.082)			39	153					0	0	0.00874	0	0
NID2	22795	broad.mit.edu	37	14	52509064	52509064	+	Silent	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:52509064T>A	uc001wzo.2	-	7	1818	c.1584A>T	c.(1582-1584)GCA>GCT	p.A528A	NID2_uc010tqs.1_Silent_p.A528A|NID2_uc010tqt.1_Silent_p.A528A|NID2_uc001wzp.2_Silent_p.A528A	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	528	Nidogen G2 beta-barrel.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CTCGGTGAGGTGCCCCTAAAA	0.512			NA											19	81					0	0	0.008871	0	0
PTGER2	5732	broad.mit.edu	37	14	52781374	52781374	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:52781374G>T	uc001wzr.2	+	1	359	c.108G>T	c.(106-108)GTG>GTT	p.V36V		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	36	Helical; Name=1; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CGGCCGGGGTGCTGGGGAACC	0.682			NA											3	29					6.4e-05	7.48051e-05	0.004672	1	0
DACT1	51339	broad.mit.edu	37	14	59112610	59112610	+	Silent	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:59112610A>G	uc001xdw.2	+	4	1433	c.1269A>G	c.(1267-1269)TCA>TCG	p.S423S	DACT1_uc010trv.1_Silent_p.S142S|DACT1_uc001xdx.2_Silent_p.S386S|DACT1_uc010trw.1_Silent_p.S142S	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	423					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						CGAAAGAATCAAAGGCCGAAC	0.567			NA											5	23					0	0	0.000602	0	0
DLST	1743	broad.mit.edu	37	14	75360125	75360125	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:75360125C>T	uc001xqv.2	+	9	733	c.670C>T	c.(670-672)CGG>TGG	p.R224W	DLST_uc001xqu.2_Missense_Mutation_p.R136W|DLST_uc001xqt.2_Missense_Mutation_p.R140W|DLST_uc010tuw.1_Missense_Mutation_p.R138W|DLST_uc001xqs.2_RNA|DLST_uc010tuv.1_Missense_Mutation_p.R224W	NM_001933	NP_001924	P36957	ODO2_HUMAN	dihydrolipoamide S-succinyltransferase (E2	224					lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	dihydrolipoyllysine-residue succinyltransferase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00698)		TTCAGAACATCGGGTAAGCCT	0.517			NA											7	44					0	0	0.00308	0	0
TTC8	123016	broad.mit.edu	37	14	89327606	89327606	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:89327606T>C	uc010ath.2	+	10	1021	c.887T>C	c.(886-888)CTT>CCT	p.L296P	TTC8_uc001xxl.2_Missense_Mutation_p.L41P|TTC8_uc010ati.2_Missense_Mutation_p.L82P|TTC8_uc001xxm.2_Missense_Mutation_p.L240P|TTC8_uc010atj.2_Intron|TTC8_uc001xxi.2_Missense_Mutation_p.L280P|TTC8_uc001xxj.2_Missense_Mutation_p.L270P|TTC8_uc001xxk.2_Missense_Mutation_p.L240P	NM_198309	NP_938051	Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8 isoform B	306	TPR 3.				cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding				0						GCTTTAAATCTTTTCAAACAA	0.289			NA							Bardet-Biedl_syndrome				3	80					0	0	0.009096	0	0
CATSPERB	79820	broad.mit.edu	37	14	92074741	92074741	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:92074741T>C	uc001xzs.1	-	22	2746	c.2606A>G	c.(2605-2607)TAC>TGC	p.Y869C	CATSPERB_uc010aub.1_Missense_Mutation_p.Y391C	NM_024764	NP_079040	Q9H7T0	CTSRB_HUMAN	cation channel, sperm-associated, beta	869					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(2)|skin(2)|ovary(1)	5		all_cancers(154;0.0663)|all_epithelial(191;0.236)				TGGAGGCCTGTAGTTTATCTG	0.323			NA											7	49					0	0	0.00308	0	0
RIN3	79890	broad.mit.edu	37	14	93118691	93118691	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:93118691G>T	uc001yap.2	+	6	1449	c.1297G>T	c.(1297-1299)GGC>TGC	p.G433C	RIN3_uc010auk.2_Missense_Mutation_p.G95C|RIN3_uc001yaq.2_Missense_Mutation_p.G358C|RIN3_uc001yar.1_Missense_Mutation_p.G95C|RIN3_uc001yas.1_Missense_Mutation_p.G95C	NM_024832	NP_079108	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	433	Pro-rich.				endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding			lung(2)|ovary(1)	3		all_cancers(154;0.0701)				CACGGAGCAAGGCCAGGACAC	0.657			NA											7	33					0.000157383	0.000177817	0.00308	1	0
KIAA1409	57578	broad.mit.edu	37	14	94060029	94060029	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:94060029G>A	uc001ybv.1	+	20	2588	c.2505G>A	c.(2503-2505)CTG>CTA	p.L835L	KIAA1409_uc001ybs.1_Silent_p.L835L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1012						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCCCTAGCCTGTGGAGGGTCG	0.478			NA											19	91					0	0	0.007413	0	0
KIAA1409	57578	broad.mit.edu	37	14	94158119	94158119	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:94158119C>G	uc001ybv.1	+	45	7032	c.6949C>G	c.(6949-6951)CTC>GTC	p.L2317V	KIAA1409_uc001ybs.1_Missense_Mutation_p.L2295V	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2472	Helical; (Potential).					integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		CATGTGCTCCCTCTTCCACGC	0.542			NA											9	44					0	0	0.008291	0	0
DICER1	23405	broad.mit.edu	37	14	95573988	95573988	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:95573988C>A	uc001ydw.2	-	18	2943	c.2761G>T	c.(2761-2763)GTT>TTT	p.V921F	DICER1_uc010avh.1_5'Flank|DICER1_uc001ydv.2_Missense_Mutation_p.V911F|DICER1_uc001ydx.2_Missense_Mutation_p.V921F	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	921	PAZ.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AATTTAAAAACAAAGGGTGTT	0.343			NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				12	91					1.61879e-10	2.32311e-10	0.001368	1	0
ATG2B	55102	broad.mit.edu	37	14	96756049	96756049	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:96756049G>C	uc001yfi.2	-	41	6315	c.5950C>G	c.(5950-5952)CAC>GAC	p.H1984D		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1984										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ACTGGCTGGTGGGCTAACCGG	0.522			NA											20	93					0	0	0.008871	0	0
TDRD9	122402	broad.mit.edu	37	14	104490907	104490907	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:104490907G>T	uc001yom.3	+	25	2638	c.2608G>T	c.(2608-2610)GTG>TTG	p.V870L	TDRD9_uc001yon.3_Missense_Mutation_p.V608L	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	870					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				ATTATGTAGGGTGAATGTGGA	0.323			NA											6	54					8.12818e-05	9.33828e-05	0.001984	1	0
AHNAK2	113146	broad.mit.edu	37	14	105418880	105418880	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr14:105418880C>A	uc010axc.1	-	7	3028	c.2908G>T	c.(2908-2910)GCC>TCC	p.A970S	AHNAK2_uc001ypx.2_Missense_Mutation_p.A870S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	970						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCCTTCTGGGCCTGGACATCC	0.607			NA											38	212					5.43694e-19	8.65256e-19	0.005524	1	0
RYR3	6263	broad.mit.edu	37	15	33936678	33936678	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:33936678C>T	uc001zhi.2	+	28	3793	c.3723C>T	c.(3721-3723)CTC>CTT	p.L1241L	RYR3_uc010bar.2_Silent_p.L1241L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1241	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCAAGCGCCTCCCGACGTTTG	0.502			NA											5	26					0	0	0.001168	0	0
MEIS2	4212	broad.mit.edu	37	15	37187407	37187407	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:37187407C>A	uc001zjr.2	-	11	2129	c.1092G>T	c.(1090-1092)CAG>CAT	p.Q364H	MEIS2_uc001zjl.2_Missense_Mutation_p.Q351H|MEIS2_uc010ucj.1_Missense_Mutation_p.Q344H|MEIS2_uc001zjm.2_Missense_Mutation_p.Q269H|MEIS2_uc001zjn.2_Missense_Mutation_p.Q218H|MEIS2_uc001zjo.2_Missense_Mutation_p.Q364H|MEIS2_uc001zjp.2_Missense_Mutation_p.Q357H|MEIS2_uc001zjs.2_Missense_Mutation_p.Q357H|MEIS2_uc001zju.2_Missense_Mutation_p.Q344H|MEIS2_uc001zjt.2_Missense_Mutation_p.Q357H|MEIS2_uc001zjj.2_Missense_Mutation_p.Q60H|MEIS2_uc001zjk.2_Missense_Mutation_p.Q53H	NM_170675	NP_733775	O14770	MEIS2_HUMAN	Meis homeobox 2 isoform c	364					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)	2		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		TCCCCATGGGCTGACCCTCTG	0.537			NA											10	71					3.07112e-06	3.79482e-06	0.000978	1	0
UNC13C	440279	broad.mit.edu	37	15	54914534	54914534	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:54914534C>A	uc002ack.2	+	29	6116	c.6116C>A	c.(6115-6117)TCC>TAC	p.S2039Y	UNC13C_uc002acm.2_5'UTR	NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	2039					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GGTCGTTCCTCCAAAGATGCC	0.408			NA											9	66					0.00010058	0.00011523	0.001368	1	0
SMAD3	4088	broad.mit.edu	37	15	67473723	67473723	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:67473723G>A	uc002aqj.2	+	6	1101	c.803G>A	c.(802-804)CGC>CAC	p.R268H	SMAD3_uc010ujr.1_Missense_Mutation_p.R163H|SMAD3_uc010ujs.1_Missense_Mutation_p.R224H|SMAD3_uc010ujt.1_Missense_Mutation_p.R73H	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	268	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		AATTCGGAGCGCTTCTGCCTA	0.607			NA											5	29					0	0	0.001984	0	0
PTPN9	5780	broad.mit.edu	37	15	75816577	75816577	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:75816577C>G	uc002bal.2	-	3	778	c.270G>C	c.(268-270)GAG>GAC	p.E90D		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	90	CRAL-TRIO.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						CACTGAGGATCTCAGAACGAA	0.393			NA											14	77					0	0	0.006122	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100801699	100801699	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:100801699G>C	uc002bvv.1	-	6	1095	c.1016C>G	c.(1015-1017)GCC>GGC	p.A339G	ADAMTS17_uc002bvx.1_Missense_Mutation_p.A96G	NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	339	Peptidase M12B.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CACAAACACGGCAGCATCCAC	0.537			NA											6	23					0	0	0.001984	0	0
PARN	5073	broad.mit.edu	37	16	14711498	14711498	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:14711498T>C	uc010uzd.1	-	6	479	c.337A>G	c.(337-339)ATT>GTT	p.I113V	PARN_uc010uzc.1_Missense_Mutation_p.I52V|PARN_uc010uze.1_Missense_Mutation_p.I67V|PARN_uc010uzf.1_Intron|PARN_uc010uzg.1_RNA	NM_002582	NP_002573	O95453	PARN_HUMAN	poly(A)-specific ribonuclease (deadenylation	113				I->A: Loss of dimerization. Loss of activity.	female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			ovary(2)	2						AGAAAGTCAATGCTGGAGCTC	0.348			NA											8	54					0	0	0.006214	0	0
NDE1	54820	broad.mit.edu	37	16	15785148	15785148	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:15785148C>T	uc002ddt.1	+	5	714	c.671C>T	c.(670-672)TCA>TTA	p.S224L	NDE1_uc010uzy.1_Missense_Mutation_p.S224L|NDE1_uc002dds.2_Missense_Mutation_p.S224L|NDE1_uc002ddu.1_Missense_Mutation_p.S161L	NM_017668	NP_060138	Q9NXR1	NDE1_HUMAN	nuclear distribution gene E homolog 1	224	Interaction with CENPF (By similarity).				cell differentiation|cell division|centrosome duplication|establishment of chromosome localization|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|mitotic prometaphase|nervous system development	cleavage furrow|condensed chromosome kinetochore|cytosol|microtubule|spindle pole centrosome	microtubule binding			ovary(1)	1						GGACCCAGCTCAAGTTTAAAC	0.572			NA											6	19					0	0	0.001168	0	0
GPR139	124274	broad.mit.edu	37	16	20043936	20043937	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:20043936_20043937GG>TT	uc002dgu.1	-	2	344_345	c.182_183CC>AA	c.(181-183)TCC>TAA	p.S61*	GPR139_uc010vaw.1_5'UTR	NM_001002911	NP_001002911	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	61	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)	2						AGTTGTAGGAGGACTTCTGTCT	0.45			NA											10	42					0	0	0.004672	0	0
GP2	2813	broad.mit.edu	37	16	20329664	20329664	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:20329664C>A	uc002dgv.2	-	8	1188	c.1105G>T	c.(1105-1107)GGG>TGG	p.G369W	GP2_uc002dgw.2_Missense_Mutation_p.G366W|GP2_uc002dgx.2_Missense_Mutation_p.G222W|GP2_uc002dgy.2_Missense_Mutation_p.G219W	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	369	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						ACTGCATCCCCTTCGTAAGGA	0.507			NA											42	146					3.43241e-23	5.68363e-23	0.009718	1	0
ACSM5	54988	broad.mit.edu	37	16	20429494	20429494	+	Silent	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:20429494G>C	uc002dhe.2	+	3	465	c.318G>C	c.(316-318)CTG>CTC	p.L106L	ACSM5_uc002dhd.1_Silent_p.L106L	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	106					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						CCAATGTGCTGGGGGGTGCAT	0.617			NA											9	33					0	0	0.006214	0	0
SLC12A3	6559	broad.mit.edu	37	16	56913484	56913484	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:56913484C>T	uc010ccm.2	+	11	1395	c.1366C>T	c.(1366-1368)CTG>TTG	p.L456L	SLC12A3_uc002ekd.3_Silent_p.L456L|SLC12A3_uc010ccn.2_Silent_p.L455L	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	456	Helical; (Potential).				sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	CTTCGCGCCCCTGATCACGGC	0.642			NA											14	35					0	0	0.004007	0	0
GINS2	51659	broad.mit.edu	37	16	85712182	85712182	+	Silent	SNP	A	A	G	rs138755140		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr16:85712182A>G	uc002fja.2	-	4	480	c.396T>C	c.(394-396)GCT>GCC	p.A132A		NM_016095	NP_057179	Q9Y248	PSF2_HUMAN	DNA replication complex GINS protein PSF2	132					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	nucleoplasm	protein binding				0						CAAAGCTGTCAGCAGACACTC	0.557			NA											22	54					0	0	0.002299	0	0
OR1A2	26189	broad.mit.edu	37	17	3101096	3101096	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:3101096G>A	uc002fvd.1	+	1	284	c.284G>A	c.(283-285)GGG>GAG	p.G95E		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	95	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						ATCTCCTTTGGGGGATGCCTA	0.517			NA											22	82					0	0	0.010504	0	0
OR3A3	8392	broad.mit.edu	37	17	3324736	3324737	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:3324736_3324737CC>AA	uc010vrd.1	+	1	875_876	c.875_876CC>AA	c.(874-876)CCC>CAA	p.P292Q		NM_012373	NP_036505	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A,	292	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTGATCAACCCCATGCTGAACC	0.495			NA											34	65					0	0	0.004672	0	0
TP53	7157	broad.mit.edu	37	17	7577609	7577609	+	Splice_Site	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:7577609C>G	uc002gim.2	-	7	867	c.673_splice	c.e7-1	p.V225_splice	TP53_uc002gig.1_Splice_Site_p.V225_splice|TP53_uc002gih.2_Splice_Site_p.V225_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Splice_Site_p.V93_splice|TP53_uc010cng.1_Splice_Site_p.V93_splice|TP53_uc002gii.1_Splice_Site_p.V93_splice|TP53_uc010cnh.1_Splice_Site_p.V225_splice|TP53_uc010cni.1_Splice_Site_p.V225_splice|TP53_uc002gij.2_Splice_Site_p.V225_splice|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(12)|p.0?(7)|p.V225fs*24(1)|p.E224_V225insXX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGAGCCAACCTAGGAGATAA	0.488	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	17					0	0	0.00245	0	0
SHMT1	6470	broad.mit.edu	37	17	18243507	18243507	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:18243507C>A	uc002gta.2	-	7	854	c.664G>T	c.(664-666)GGG>TGG	p.G222W	SHMT1_uc002gsz.2_5'UTR|SHMT1_uc002gtb.2_Missense_Mutation_p.G222W|SHMT1_uc010cqb.2_Missense_Mutation_p.G222W|SHMT1_uc010vxt.1_Missense_Mutation_p.G84W|SHMT1_uc002gtd.1_Missense_Mutation_p.G222W	NM_004169	NP_004160	P34896	GLYC_HUMAN	serine hydroxymethyltransferase 1 (soluble)	222					carnitine biosynthetic process|folic acid metabolic process|L-serine catabolic process|one-carbon metabolic process|purine base biosynthetic process	cytosol|nucleus	glycine hydroxymethyltransferase activity|protein homodimerization activity|pyridoxal phosphate binding			ovary(1)	1					Glycine(DB00145)|Mimosine(DB01055)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	AGATACGCCCCGTTCTCATCT	0.582			NA											22	94					1.64293e-13	2.45241e-13	0.00333	1	0
LGALS9	3965	broad.mit.edu	37	17	25974363	25974363	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:25974363G>T	uc002gzp.2	+	10	944	c.826G>T	c.(826-828)GCT>TCT	p.A276S	LGALS9_uc002gzq.2_Missense_Mutation_p.A244S|LGALS9_uc002gzr.2_Missense_Mutation_p.A187S|LGALS9_uc010waa.1_Intron|LGALS9_uc002gzs.2_Intron	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	276	Galectin 2.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		TGATGAGAATGCTGTGGTCCG	0.572	Melanoma(106;677 1527 28724 29571 46552)|Ovarian(193;263 2088 2118 29005 43023)		NA											7	53					0.000157383	0.000177817	0.00308	1	0
NOS2	4843	broad.mit.edu	37	17	26114746	26114746	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:26114746T>A	uc002gzu.2	-	5	689	c.425A>T	c.(424-426)CAA>CTA	p.Q142L	NOS2_uc010crh.1_Missense_Mutation_p.Q142L|NOS2_uc010wab.1_Missense_Mutation_p.Q142L	NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	142					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	TTCGATAGCTTGAGGTAGAAG	0.527			NA											20	169					0	0	0.010504	0	0
SLC13A2	9058	broad.mit.edu	37	17	26818601	26818601	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:26818601G>A	uc002hbh.2	+	5	788	c.721G>A	c.(721-723)GCA>ACA	p.A241T	SLC13A2_uc010wal.1_Missense_Mutation_p.A198T|SLC13A2_uc010wam.1_Missense_Mutation_p.A197T|SLC13A2_uc010wan.1_Missense_Mutation_p.A290T|SLC13A2_uc010wao.1_Missense_Mutation_p.A198T|SLC13A2_uc002hbi.2_Missense_Mutation_p.A170T	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	241	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GACTGGCACCGCACCCAACCT	0.627			NA											11	57					0	0	0.001368	0	0
TMIGD1	388364	broad.mit.edu	37	17	28656339	28656339	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:28656339G>A	uc002hfa.1	-	3	364	c.291C>T	c.(289-291)AAC>AAT	p.N97N	TMIGD1_uc010csh.1_Silent_p.N97N	NM_206832	NP_996663	Q6UXZ0	TMIG1_HUMAN	transmembrane and immunoglobulin domain	97	Extracellular (Potential).|Ig-like C2-type 1.					integral to membrane					0						AGCTGATTCCGTTGTCATTTT	0.488			NA											12	76					0	0	0.001368	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	A	T	rs113059833	by1000genomes	TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:39261693A>T	uc010wfp.1	+	1	53	c.53A>T	c.(52-54)GAC>GTC	p.D18V		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament					0						TGCGGCCAAGACCTCTGTCAG	0.627			NA											5	25					0	0	0.000602	0	0
KRT14	3861	broad.mit.edu	37	17	39739908	39739908	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:39739908C>T	uc002hxf.1	-	5	1009	c.948G>A	c.(946-948)GAG>GAA	p.E316E	JUP_uc010wfs.1_Intron|KRT14_uc010cxp.1_Silent_p.E316E	NM_000526	NP_000517	P02533	K1C14_HUMAN	keratin 14	316	Rod.|Coil 2.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			ovary(1)	1		Breast(137;0.000307)				TGGTGGCCACCTCGCGGTTCA	0.587			NA											23	102					0	0	0.003954	0	0
WNK4	65266	broad.mit.edu	37	17	40933017	40933017	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:40933017A>G	uc002ibj.2	+	1	322	c.301A>G	c.(301-303)AGC>GGC	p.S101G	WNK4_uc010wgx.1_5'UTR|WNK4_uc002ibk.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	101					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCCACCGCCTAGCTCCAAAGA	0.726	Esophageal Squamous(6;201 374 4964 23855 42828)		NA											7	18					0	0	0.00308	0	0
BRCA1	672	broad.mit.edu	37	17	41251814	41251814	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:41251814C>A	uc002icq.2	-	7	757	c.525G>T	c.(523-525)AAG>AAT	p.K175N	BRCA1_uc010whp.1_Missense_Mutation_p.K128N|BRCA1_uc010whl.1_Missense_Mutation_p.K175N|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.K104N|BRCA1_uc002icu.2_Missense_Mutation_p.K175N|BRCA1_uc010cyx.2_Missense_Mutation_p.K128N|BRCA1_uc002ict.2_Missense_Mutation_p.K175N|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Missense_Mutation_p.K48N|BRCA1_uc002idc.1_Missense_Mutation_p.K174N|BRCA1_uc010whr.1_Missense_Mutation_p.K128N|BRCA1_uc002idd.2_Missense_Mutation_p.K175N|BRCA1_uc002ide.1_Missense_Mutation_p.K47N|BRCA1_uc010cyy.1_Missense_Mutation_p.K175N|BRCA1_uc010whs.1_Missense_Mutation_p.K175N|BRCA1_uc010cyz.2_Missense_Mutation_p.K128N|BRCA1_uc010cza.2_Missense_Mutation_p.K149N|BRCA1_uc010wht.1_Intron	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	175					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		AGACAGACGTCTTTTGAGGTT	0.383			NA	D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			31	173					6.53348e-20	1.04792e-19	0.003755	1	0
KIF2B	84643	broad.mit.edu	37	17	51901824	51901824	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:51901824C>T	uc002iua.2	+	1	1586	c.1430C>T	c.(1429-1431)GCC>GTC	p.A477V	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	477					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGTCTTCTAGCCCTCAAAGAA	0.512			NA											7	37					0	0	0.001984	0	0
TBC1D3P2	440452	broad.mit.edu	37	17	60351180	60351180	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:60351180G>T	uc002izq.2	-	3	247	c.135C>A	c.(133-135)AAC>AAA	p.N45K	TBC1D3P2_uc010woz.1_RNA					SubName: Full=Putative uncharacterized protein TBC1D3E;												0						AGTGATCGATGTTGTTGTTGT	0.557			NA											39	133					3.61848e-18	5.73627e-18	0.007835	1	0
TBC1D16	125058	broad.mit.edu	37	17	77987181	77987181	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:77987181C>A	uc002jxj.2	-	2	282	c.166G>T	c.(166-168)GGG>TGG	p.G56W		NM_019020	NP_061893	Q8TBP0	TBC16_HUMAN	TBC1 domain family, member 16	56						intracellular	Rab GTPase activator activity				0	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.00739)|BRCA - Breast invasive adenocarcinoma(99;0.0819)			TGGTGCTCCCCCAGCCCCTGC	0.667	Ovarian(14;397 562 4850 31922 49378)		NA											3	20					2.56e-06	3.1922e-06	0.009096	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14852116	14852116	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr18:14852116G>T	uc010dlo.2	+	36	3996	c.3816G>T	c.(3814-3816)CAG>CAT	p.Q1272H	ANKRD30B_uc010xal.1_Missense_Mutation_p.Q414H	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1357	Potential.									ovary(1)|skin(1)	2						GTGAAACACAGTGTCAAATGA	0.368			NA											6	20					0.00198382	0.00214651	0.001984	1	0
ASXL3	80816	broad.mit.edu	37	18	31323961	31323961	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr18:31323961C>T	uc010dmg.1	+	12	4204	c.4149C>T	c.(4147-4149)GCC>GCT	p.A1383A	ASXL3_uc002kxq.2_Silent_p.A1090A	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1383					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AAGAACAGGCCACTGTATCCA	0.507			NA									OREG0024911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	71					0	0	0.000978	0	0
FHOD3	80206	broad.mit.edu	37	18	34310681	34310681	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr18:34310681G>T	uc002kzt.1	+	16	3011	c.2914G>T	c.(2914-2916)GGT>TGT	p.G972C	FHOD3_uc002kzs.1_Missense_Mutation_p.G989C|FHOD3_uc010dmz.1_Missense_Mutation_p.G704C|FHOD3_uc010dnb.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	972	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				CATCAATATTGGTCTGACGGT	0.428			NA											14	87					3.27435e-08	4.30614e-08	0.00245	1	0
LRRC8E	80131	broad.mit.edu	37	19	7965609	7965609	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:7965609G>A	uc002mir.2	+	3	2303	c.2202G>A	c.(2200-2202)CTG>CTA	p.L734L		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	734	LRR 10.					integral to membrane				lung(1)|pancreas(1)	2						ACAACCAGCTGAGCCAGCTCT	0.632			NA											8	51					0	0	0.004482	0	0
MUC16	94025	broad.mit.edu	37	19	9048033	9048033	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:9048033C>A	uc002mkp.2	-	5	33802	c.33598G>T	c.(33598-33600)GTC>TTC	p.V11200F		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11202	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTAGGGGAGACAGCTAAAGTT	0.453			NA											9	14					1.12685e-05	1.35554e-05	0.004482	1	0
MUC16	94025	broad.mit.edu	37	19	9087382	9087382	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:9087382C>T	uc002mkp.2	-	1	4637	c.4433G>A	c.(4432-4434)AGT>AAT	p.S1478N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1478	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGAACTTGGACTTGAAATATC	0.448			NA											31	155					0	0	0.009535	0	0
ZNF439	90594	broad.mit.edu	37	19	11978562	11978562	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:11978562C>T	uc002mss.2	+	3	806	c.678C>T	c.(676-678)CTC>CTT	p.L226L	ZNF439_uc002msr.2_Silent_p.L90L	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	226	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TCCATTGTCTCAGTTTATATC	0.358			NA											23	116					0	0	0.002299	0	0
ZNF492	57615	broad.mit.edu	37	19	22847981	22847981	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:22847981C>T	uc002nqw.3	+	4	1754	c.1510C>T	c.(1510-1512)CTC>TTC	p.L504F		NM_020855	NP_065906	Q9P255	ZN492_HUMAN	zinc finger protein 492	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				TGGAGAGAAACTCTACAAACC	0.343			NA											8	10					0	0	0.000978	0	0
NFKBID	84807	broad.mit.edu	37	19	36380905	36380905	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:36380905C>A	uc002oci.1	-	11	1349	c.775G>T	c.(775-777)GCC>TCC	p.A259S	NFKBID_uc002och.1_Missense_Mutation_p.A96S|NFKBID_uc002ocj.1_Missense_Mutation_p.A274S	NM_139239	NP_640332	Q8NI38	IKBD_HUMAN	nuclear factor of kappa light polypeptide gene	259	ANK 6.				inflammatory response	nucleus					0						GCCTCCTGGGCCGGCCCAGGG	0.706			NA											7	17					2.0095e-06	2.53668e-06	0.001984	1	0
SUPT5H	6829	broad.mit.edu	37	19	39959770	39959770	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:39959770C>T	uc002olo.3	+	15	1374	c.1195C>T	c.(1195-1197)CAG>TAG	p.Q399*	SUPT5H_uc002olp.3_Nonsense_Mutation_p.Q399*|SUPT5H_uc002olq.3_Nonsense_Mutation_p.Q395*|SUPT5H_uc002oln.3_Nonsense_Mutation_p.Q399*|SUPT5H_uc002olr.3_Nonsense_Mutation_p.Q399*|SUPT5H_uc002ols.1_Nonsense_Mutation_p.Q22*|SUPT5H_uc010egp.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	399	Interaction with RNA polymerase II.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTTTGAGGACCAGCCAGAGGG	0.577			NA											13	49					0	0	0.001855	0	0
CEACAM19	56971	broad.mit.edu	37	19	45175887	45175887	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:45175887G>T	uc002ozo.3	+	2	555	c.75G>T	c.(73-75)TGG>TGT	p.W25C	CEACAM19_uc002ozp.3_Missense_Mutation_p.W25C	NM_020219	NP_064604	Q7Z692	CEA19_HUMAN	carcinoembryonic antigen-related cell adhesion	25						integral to membrane					0	Lung NSC(12;0.00308)|all_lung(12;0.00806)	Prostate(69;0.0376)				TGGTCCTCTGGATGCTCCAAG	0.552			NA											18	42					8.00594e-06	9.68766e-06	0.007413	1	0
GPR77	27202	broad.mit.edu	37	19	47845055	47845055	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:47845055G>T	uc010ela.1	+	2	1217	c.999G>T	c.(997-999)TCG>TCT	p.S333S	GPR77_uc002pgk.1_Silent_p.S333S	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	333	Cytoplasmic (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		ACCTGGTCTCGGAGATGGAGG	0.458			NA											3	31					2.56e-06	3.1922e-06	0.009096	1	0
TSKS	60385	broad.mit.edu	37	19	50245161	50245161	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:50245161C>A	uc002ppm.2	-	9	1489	c.1478G>T	c.(1477-1479)AGG>ATG	p.R493M		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	493							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CTTGTGTAGCCTCTGACAGCT	0.582			NA											8	78					2.74318e-10	3.86883e-10	0.006214	1	0
SIGLEC6	946	broad.mit.edu	37	19	52033116	52033116	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:52033116C>T	uc002pwy.2	-	5	1036	c.874G>A	c.(874-876)GCC>ACC	p.A292T	SIGLEC6_uc002pwz.2_Missense_Mutation_p.A276T|SIGLEC6_uc002pxa.2_Missense_Mutation_p.A292T|SIGLEC6_uc010ydb.1_Missense_Mutation_p.A229T|SIGLEC6_uc010ydc.1_Missense_Mutation_p.A292T|SIGLEC6_uc010eoz.1_Missense_Mutation_p.A270T|SIGLEC6_uc010epb.1_Missense_Mutation_p.A245T|SIGLEC6_uc010epa.1_Missense_Mutation_p.A281T	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	292	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GCGTTCAGGGCGGGGAAGCCC	0.637			NA											11	61					0	0	0.001368	0	0
LILRA6	79168	broad.mit.edu	37	19	54745485	54745485	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:54745485G>T	uc002qeu.1	-	4	749	c.625C>A	c.(625-627)CAC>AAC	p.H209N	LILRB3_uc002qeh.1_Intron|LILRB3_uc002qeg.1_Intron|LILRB3_uc002qei.1_Missense_Mutation_p.H209N|LILRA6_uc002qek.1_Missense_Mutation_p.H209N|LILRB3_uc010erh.1_Intron|LILRB3_uc002qej.1_Intron|LILRA6_uc002qel.1_Missense_Mutation_p.H209N|LILRA6_uc002qem.1_RNA|LILRB3_uc002qen.1_Intron|LILRB3_uc002qeo.1_Missense_Mutation_p.H209N|LILRB3_uc002qep.1_Intron|LILRB3_uc002qeq.1_Missense_Mutation_p.H209N|LILRB3_uc002qer.1_RNA|LILRB3_uc002qes.1_Missense_Mutation_p.H209N|LILRA6_uc010yep.1_Missense_Mutation_p.H209N|LILRA6_uc010yeq.1_Missense_Mutation_p.H209N|LILRA6_uc002qet.3_Intron|LILRA6_uc002qev.1_Missense_Mutation_p.H70N	NM_024318	NP_077294	Q6PI73	LIRA6_HUMAN	leukocyte immunoglobulin-like receptor,	209	Extracellular (Potential).					integral to membrane	receptor activity			skin(2)	2	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCACTGGGGTGGGACCACACC	0.612			NA											19	85					3.85864e-22	6.31274e-22	0.00278	1	0
LILRB1	10859	broad.mit.edu	37	19	55143393	55143393	+	Nonsense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:55143393C>G	uc002qgj.2	+	6	706	c.366C>G	c.(364-366)TAC>TAG	p.Y122*	LILRB1_uc010erp.1_Intron|LILRB1_uc002qgl.2_Nonsense_Mutation_p.Y122*|LILRB1_uc002qgk.2_Nonsense_Mutation_p.Y122*|LILRB1_uc002qgm.2_Nonsense_Mutation_p.Y122*|LILRB1_uc010erq.2_Nonsense_Mutation_p.Y122*|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	122	Ig-like C2-type 2.|Extracellular (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		TAGGAGCCTACATCAAACCCA	0.592			NA								HNSCC(37;0.09)			6	63					0	0	0.001984	0	0
PEG3	5178	broad.mit.edu	37	19	57327625	57327625	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:57327625T>C	uc002qnu.2	-	7	2536	c.2185A>G	c.(2185-2187)ACT>GCT	p.T729A	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.T700A|PEG3_uc002qnv.2_Missense_Mutation_p.T729A|PEG3_uc002qnw.2_Missense_Mutation_p.T605A|PEG3_uc002qnx.2_Missense_Mutation_p.T603A|PEG3_uc010etr.2_Missense_Mutation_p.T729A	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	729					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGAGATTCAGTGAATGGCCCA	0.423			NA											44	85					0	0	0.002522	0	0
ZNF304	57343	broad.mit.edu	37	19	57868358	57868358	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr19:57868358G>C	uc010ygw.1	+	3	1509	c.1121G>C	c.(1120-1122)CGT>CCT	p.R374P	ZNF304_uc010etw.2_Missense_Mutation_p.R421P|ZNF304_uc010etx.2_Missense_Mutation_p.R332P	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	374	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		GCCTTTAGCCGTAAAGACACA	0.448			NA											15	42					0	0	0.004007	0	0
ASAP2	8853	broad.mit.edu	37	2	9540191	9540191	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:9540191G>T	uc002qzh.2	+	25	3064	c.2724G>T	c.(2722-2724)CCG>CCT	p.P908P	ASAP2_uc002qzi.2_Silent_p.P863P	NM_003887	NP_003878	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	908	Pro-rich.				regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding				0						AAGGCCAACCGAGAGGACCTG	0.517			NA											5	49					0.000602214	0.000665691	0.000602	1	0
ATP6V1C2	245973	broad.mit.edu	37	2	10917755	10917755	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:10917755G>A	uc002ras.2	+	11	979	c.870G>A	c.(868-870)CCG>CCA	p.P290P	ATP6V1C2_uc002rat.2_Intron	NM_001039362	NP_001034451	Q8NEY4	VATC2_HUMAN	vacuolar H+ ATPase C2 isoform a	290					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		CCACCTTCCCGGACCACAAGG	0.483	NSCLC(188;1042 2136 10807 16813 47705)		NA											39	88					0	0	0.006999	0	0
NBAS	51594	broad.mit.edu	37	2	15427279	15427279	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:15427279C>A	uc002rcc.1	-	42	5082	c.5056G>T	c.(5056-5058)GCT>TCT	p.A1686S	NBAS_uc010exl.1_Missense_Mutation_p.A758S|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1686										ovary(2)|liver(1)|skin(1)	4						AGAGAAATAGCAATGCTGTAG	0.468			NA											9	54					2.17888e-05	2.59814e-05	0.006214	1	0
OTOF	9381	broad.mit.edu	37	2	26683600	26683600	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:26683600C>A	uc002rhk.2	-	45	5855	c.5728G>T	c.(5728-5730)GAG>TAG	p.E1910*	OTOF_uc010yla.1_Nonsense_Mutation_p.E640*|OTOF_uc002rhh.2_Nonsense_Mutation_p.E1143*|OTOF_uc002rhi.2_Nonsense_Mutation_p.E1220*|OTOF_uc002rhj.2_Nonsense_Mutation_p.E1143*	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	1910	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAATGCAGCTCAGCCTCCACC	0.647	GBM(102;732 1451 20652 24062 31372)		NA											4	21					2.56e-06	3.1922e-06	0.009096	1	0
AGBL5	60509	broad.mit.edu	37	2	27292958	27292958	+	Splice_Site	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:27292958A>T	uc002rie.2	+	15	2707	c.2490_splice	c.e15-2	p.G830_splice	AGBL5_uc002rif.2_Splice_Site	NM_021831	NP_068603	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5 isoform 1						protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTCTGTTGCAGGCTGCCTCA	0.547			NA											12	73					0	0	0.00245	0	0
XDH	7498	broad.mit.edu	37	2	31611101	31611101	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:31611101C>A	uc002rnv.1	-	7	635	c.556G>T	c.(556-558)GAC>TAC	p.D186Y		NM_000379	NP_000370	P47989	XDH_HUMAN	xanthine dehydrogenase	186					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			skin(4)|breast(2)|ovary(1)|central_nervous_system(1)	8	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	ACTGAGTGGTCTTTCTTCTGG	0.502	Colon(66;682 1445 30109 40147)		NA											7	52					0.000157383	0.000177817	0.00308	1	0
HEATR5B	54497	broad.mit.edu	37	2	37227729	37227729	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:37227729C>A	uc002rpp.1	-	33	5641	c.5545G>T	c.(5545-5547)GAA>TAA	p.E1849*	HEATR5B_uc002rpo.1_Missense_Mutation_p.D162Y|HEATR5B_uc010ezy.1_Nonsense_Mutation_p.E344*	NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	1849							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				GATAGGTTACCTGGTTGAGAA	0.388			NA											6	73					0.00116845	0.00128122	0.001168	1	0
PKDCC	91461	broad.mit.edu	37	2	42284449	42284449	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:42284449G>T	uc002rsg.2	+	6	1490	c.1311G>T	c.(1309-1311)GTG>GTT	p.V437V		NM_138370	NP_612379	Q504Y2	PKDCC_HUMAN	protein kinase-like protein SgK493	437	Protein kinase.				cell differentiation|embryonic digestive tract development|lung alveolus development|negative regulation of Golgi to plasma membrane protein transport|ossification|palate development|positive regulation of bone mineralization|positive regulation of chondrocyte differentiation|protein transport	Golgi apparatus	ATP binding|protein kinase activity			breast(1)	1						TCCTTTCAGTGTTCAACCTGG	0.602			NA											9	111					0.000442599	0.000491911	0.006214	1	0
MTA3	57504	broad.mit.edu	37	2	42883392	42883392	+	Silent	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:42883392A>T	uc002rso.1	+	8	1054	c.384A>T	c.(382-384)CCA>CCT	p.P128P	MTA3_uc002rsp.1_Silent_p.P128P|MTA3_uc002rsq.2_Silent_p.P184P|MTA3_uc002rsr.2_Silent_p.P184P	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	184	ELM2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						TTTGGGATCCAAATAGCCCAC	0.353			NA											20	67					0	0	0.004656	0	0
FBXO11	80204	broad.mit.edu	37	2	48066010	48066010	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:48066010T>A	uc010fbl.2	-	4	437	c.323A>T	c.(322-324)GAT>GTT	p.D108V	FBXO11_uc002rwe.2_Missense_Mutation_p.D108V|FBXO11_uc002rwf.2_Missense_Mutation_p.D108V|FBXO11_uc002rwg.1_Missense_Mutation_p.D108V	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	192	F-box.				ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CAAAATTGGATCATTAGCAAG	0.383			NA											12	41					0	0	0.001368	0	0
PNPT1	87178	broad.mit.edu	37	2	55894127	55894127	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:55894127T>A	uc002rzf.2	-	13	1228	c.1175A>T	c.(1174-1176)CAG>CTG	p.Q392L	PNPT1_uc002rzg.2_RNA	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1	392					mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ATAAATTACCTGTGTTTGTCC	0.318			NA											7	48					0	0	0.001984	0	0
DYSF	8291	broad.mit.edu	37	2	71839888	71839888	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:71839888C>T	uc002sie.2	+	39	4661	c.4285C>T	c.(4285-4287)CTG>TTG	p.L1429L	DYSF_uc010feg.2_Silent_p.L1460L|DYSF_uc010feh.2_Silent_p.L1415L|DYSF_uc002sig.3_Silent_p.L1415L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.L1429L|DYSF_uc010fef.2_Silent_p.L1446L|DYSF_uc010fei.2_Silent_p.L1446L|DYSF_uc010fek.2_Silent_p.L1447L|DYSF_uc010fej.2_Silent_p.L1416L|DYSF_uc010fel.2_Silent_p.L1416L|DYSF_uc010feo.2_Silent_p.L1461L|DYSF_uc010fem.2_Silent_p.L1430L|DYSF_uc010fen.2_Silent_p.L1447L|DYSF_uc002sif.2_Silent_p.L1430L|DYSF_uc010yqy.1_Silent_p.L310L|DYSF_uc010yqz.1_Silent_p.L169L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1429	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						GGAGAGCTTCCTGTGTGACCC	0.657			NA											7	21					0	0	0.001984	0	0
DNAH6	1768	broad.mit.edu	37	2	84775457	84775457	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:84775457A>G	uc010fgb.2	+	8	1369	c.1232A>G	c.(1231-1233)CAT>CGT	p.H411R	DNAH6_uc002soo.2_5'UTR|DNAH6_uc002sop.2_5'UTR	NM_001370	NP_001361	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy polypeptide 6	411	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			central_nervous_system(1)	1						AATACACCACATGAGTTGCCC	0.383			NA											8	59					0	0	0.00308	0	0
PROM2	150696	broad.mit.edu	37	2	95953996	95953996	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:95953996G>T	uc002suh.1	+	21	2415	c.2282G>T	c.(2281-2283)GGA>GTA	p.G761V	PROM2_uc002sui.2_Missense_Mutation_p.G761V|PROM2_uc002suj.2_Missense_Mutation_p.G415V|PROM2_uc002suk.2_Missense_Mutation_p.G761V|PROM2_uc002sul.2_Missense_Mutation_p.G287V|PROM2_uc002sum.2_RNA	NM_144707	NP_653308	Q8N271	PROM2_HUMAN	prominin 2 precursor	761	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				ovary(1)	1						CCCCTCTCCGGAGCCCTGGAC	0.622			NA											11	85					9.70103e-10	1.34499e-09	0.008291	1	0
IL1F6	27179	broad.mit.edu	37	2	113764288	113764288	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:113764288G>T	uc010yxr.1	+	3	238	c.238G>T	c.(238-240)GGG>TGG	p.G80W		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	80					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding	p.G80R(1)			0						TGCTAAAGTCGGGGACCAGCC	0.483			NA											20	131					8.10497e-08	1.06248e-07	0.010504	1	0
POTEF	728378	broad.mit.edu	37	2	130832641	130832641	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:130832641G>T	uc010fmh.2	-	17	2804	c.2404C>A	c.(2404-2406)CCC>ACC	p.P802T		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	802	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						AGCAGGACGGGGTGCTCCTCG	0.582			NA											36	93					2.40579e-17	3.77e-17	0.00623	1	0
THSD7B	80731	broad.mit.edu	37	2	138163308	138163308	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:138163308G>T	uc002tva.1	+	12	2533	c.2533G>T	c.(2533-2535)GCT>TCT	p.A845S	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.A735S	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CACCTTCACTGCTTGGTCCAA	0.507			NA											10	22					0.00621372	0.00661825	0.006214	1	0
LRP1B	53353	broad.mit.edu	37	2	140995720	140995720	+	Splice_Site	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:140995720C>G	uc002tvj.1	-	89	14532	c.13560_splice	c.e89+1	p.K4520_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGACATACTACCTTTGTTGGG	0.373	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			12	99					0	0	0.001368	0	0
LRP1B	53353	broad.mit.edu	37	2	141641581	141641581	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:141641581G>T	uc002tvj.1	-	25	4946	c.3974C>A	c.(3973-3975)GCC>GAC	p.A1325D	LRP1B_uc010fnl.1_Missense_Mutation_p.A507D	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1325	Extracellular (Potential).|LDL-receptor class B 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACTTCAATGGCACTGACACC	0.473	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			19	69					2.94398e-08	3.90938e-08	0.007413	1	0
SCN2A	6326	broad.mit.edu	37	2	166164446	166164446	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:166164446G>C	uc002udc.2	+	4	765	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	SCN2A_uc002udd.2_Missense_Mutation_p.E159Q|SCN2A_uc002ude.2_Missense_Mutation_p.E159Q	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	159	I.|Helical; Name=S2 of repeat I; (Potential).				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	AAAGAATGTGGAGTAAGTATA	0.338			NA											43	196					0	0	0.002522	0	0
CSRNP3	80034	broad.mit.edu	37	2	166533101	166533101	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:166533101G>A	uc002udf.2	+	6	1064	c.688G>A	c.(688-690)GCT>ACT	p.A230T	CSRNP3_uc002udg.2_Missense_Mutation_p.A230T	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	230	Cys-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						CTGCAGCCTGGCTGGCATTAA	0.537			NA											5	68					0	0	0.000602	0	0
CSRNP3	80034	broad.mit.edu	37	2	166535484	166535484	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:166535484G>A	uc002udf.2	+	7	1355	c.979G>A	c.(979-981)GTG>ATG	p.V327M	CSRNP3_uc002udg.2_Missense_Mutation_p.V327M	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	327	Glu-rich.				apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						CCAGGCTGCAGTGCTGCACCT	0.507			NA											29	66					0	0	0.007291	0	0
LRP2	4036	broad.mit.edu	37	2	170127535	170127535	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:170127535C>T	uc002ues.2	-	16	2412	c.2199G>A	c.(2197-2199)ATG>ATA	p.M733I	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	733	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	AAACTGGAACCATGACATCTT	0.413			NA											8	66					0	0	0.004482	0	0
HOXD10	3236	broad.mit.edu	37	2	176981647	176981647	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:176981647C>A	uc002ukj.2	+	1	156	c.86C>A	c.(85-87)TCC>TAC	p.S29Y		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	29						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		AGTTTTTATTCCAGCAGCGCC	0.488			NA											34	84					3.11337e-16	4.82337e-16	0.002836	1	0
OSBPL6	114880	broad.mit.edu	37	2	179238620	179238620	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:179238620G>T	uc002ulx.2	+	15	1777	c.1399G>T	c.(1399-1401)GGT>TGT	p.G467C	OSBPL6_uc002ulw.2_Missense_Mutation_p.G400C|OSBPL6_uc002uly.2_Missense_Mutation_p.G492C|OSBPL6_uc010zfe.1_Missense_Mutation_p.G436C|OSBPL6_uc002ulz.2_Missense_Mutation_p.G431C|OSBPL6_uc002uma.2_Missense_Mutation_p.G471C	NM_032523	NP_115912	Q9BZF3	OSBL6_HUMAN	oxysterol-binding protein-like protein 6 isoform	467					lipid transport		lipid binding			pancreas(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			TCTGCAGGCTGGTGAGCAAAT	0.433			NA											3	59					0.004672	0.00500222	0.004672	1	0
TTN	7273	broad.mit.edu	37	2	179449532	179449532	+	Silent	SNP	A	A	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:179449532A>C	uc010zfg.1	-	259	57356	c.57132T>G	c.(57130-57132)GCT>GCG	p.A19044A	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.A12739A|TTN_uc010zfi.1_Silent_p.A12672A|TTN_uc010zfj.1_Silent_p.A12547A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19971							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTGACTGAAGCTAGAGCCG	0.517			NA											30	229					0	0	0.007291	0	0
TTN	7273	broad.mit.edu	37	2	179582535	179582535	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:179582535G>C	uc010zfg.1	-	84	21558	c.21334C>G	c.(21334-21336)CGC>GGC	p.R7112G	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.R3773G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8039							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGAAGTTTGCGCGCTGTAAAG	0.378			NA											6	43					0	0	0.001168	0	0
SSFA2	6744	broad.mit.edu	37	2	182780208	182780208	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:182780208C>T	uc002uoi.2	+	11	2163	c.1841C>T	c.(1840-1842)CCA>CTA	p.P614L	SSFA2_uc002uoh.2_Missense_Mutation_p.P614L|SSFA2_uc002uoj.2_Missense_Mutation_p.P614L|SSFA2_uc002uok.2_RNA|SSFA2_uc010zfo.1_Missense_Mutation_p.P461L|SSFA2_uc002uol.2_Missense_Mutation_p.P461L|SSFA2_uc002uom.2_Missense_Mutation_p.P82L	NM_001130445	NP_001123917	P28290	SSFA2_HUMAN	sperm specific antigen 2 isoform 1	614						cytoplasm|plasma membrane	actin binding			breast(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ACCTGTAGTCCAGGGGATCAT	0.453			NA											12	63					0	0	0.001368	0	0
COL3A1	1281	broad.mit.edu	37	2	189870978	189870978	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:189870978G>T	uc002uqj.1	+	42	3203	c.3086G>T	c.(3085-3087)GGT>GTT	p.G1029V		NM_000090	NP_000081	P02461	CO3A1_HUMAN	collagen type III alpha 1 preproprotein	1029	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			central_nervous_system(7)|ovary(4)|large_intestine(2)	13			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GGATCTCCTGGTGGCAAGGTA	0.368			NA											16	91					1.33834e-09	1.8246e-09	0.007413	1	0
COL5A2	1290	broad.mit.edu	37	2	189923181	189923181	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:189923181C>G	uc002uqk.2	-	33	2478	c.2203G>C	c.(2203-2205)GGA>CGA	p.G735R	COL5A2_uc010frx.2_Missense_Mutation_p.G311R	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	735					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCATGTCCTCCAGCCATTCCC	0.433			NA											11	40					0	0	0.003163	0	0
MFSD6	54842	broad.mit.edu	37	2	191301129	191301129	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:191301129C>T	uc002urz.2	+	3	698	c.374C>T	c.(373-375)GCA>GTA	p.A125V		NM_017694	NP_060164	Q6ZSS7	MFSD6_HUMAN	major facilitator superfamily domain containing	125	Helical; (Potential).				transmembrane transport	integral to membrane				ovary(2)	2						GGTGTAGTTGCAGACCGCTTT	0.428			NA											31	80					0	0	0.002445	0	0
DNAH7	56171	broad.mit.edu	37	2	196825191	196825191	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:196825191G>T	uc002utj.3	-	18	2785	c.2684C>A	c.(2683-2685)GCT>GAT	p.A895D		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	895	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TTCTTTGCTAGCTGCTTCACT	0.403			NA											25	143					6.21321e-17	9.69925e-17	0.00278	1	0
C2orf66	401027	broad.mit.edu	37	2	197674027	197674027	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:197674027C>A	uc002utv.2	-	1	974	c.85G>T	c.(85-87)GCC>TCC	p.A29S		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	29						extracellular region					0						AGCACCAGGGCAACACATAGT	0.498			NA											20	163					8.00594e-06	9.68766e-06	0.007413	1	0
PARD3B	117583	broad.mit.edu	37	2	206364739	206364739	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:206364739A>T	uc002var.1	+	21	3371	c.3164A>T	c.(3163-3165)GAG>GTG	p.E1055V	PARD3B_uc002vao.1_Missense_Mutation_p.E954V|PARD3B_uc002vap.1_Missense_Mutation_p.E993V|PARD3B_uc002vaq.1_Missense_Mutation_p.E986V	NM_152526	NP_689739	Q8TEW8	PAR3L_HUMAN	par-3 partitioning defective 3 homolog B isoform	1055					cell cycle|cell division	endomembrane system|tight junction				skin(2)|ovary(1)|breast(1)	4		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AGGCCATCTGAGTATGACCTA	0.438			NA											45	157					0	0	0.00361	0	0
ADAM23	8745	broad.mit.edu	37	2	207452814	207452814	+	Splice_Site	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:207452814G>T	uc002vbq.2	+	20	2012	c.1789_splice	c.e20-1	p.G597_splice	ADAM23_uc010ziv.1_Splice_Site	NM_003812	NP_003803	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23 preproprotein						cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		CCTGTCCCCAGGGCCGCTGCT	0.493	Melanoma(194;1127 2130 19620 24042 27855)		NA											16	48					2.5808e-16	4.01348e-16	0.006122	1	0
ACCN4	55515	broad.mit.edu	37	2	220396524	220396524	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:220396524G>T	uc002vma.2	+	2	1022	c.1008G>T	c.(1006-1008)CCG>CCT	p.P336P	ACCN4_uc010fwi.1_Silent_p.P336P|ACCN4_uc010fwj.1_Silent_p.P336P|ACCN4_uc002vly.1_Silent_p.P336P|ACCN4_uc002vlz.2_Silent_p.P336P|ACCN4_uc002vmb.2_5'UTR	NM_182847	NP_878267	Q96FT7	ACCN4_HUMAN	amiloride-sensitive cation channel 4 isoform 2	336	Extracellular (Potential).					integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity			ovary(2)	2		Renal(207;0.0183)		Epithelial(149;5.47e-10)|all cancers(144;9e-08)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.0086)|READ - Rectum adenocarcinoma(5;0.156)		ACGCGGACCCGCGGAGCTCGC	0.617			NA											29	85					2.4375e-19	3.89428e-19	0.007291	1	0
SIRPB1	10326	broad.mit.edu	37	20	1551451	1551451	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr20:1551451C>A	uc010gai.2	-	4	1183	c.1084G>T	c.(1084-1086)GAA>TAA	p.E362*	SIRPB1_uc002wfk.3_Intron	NM_006065	NP_006056	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1 isoform 1	362	Extracellular (Potential).				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			ovary(1)	1						GTAACCGCACCATGGGTGATA	0.413			NA											38	104					2.35958e-20	3.81451e-20	0.009718	1	0
C20orf103	24141	broad.mit.edu	37	20	9496758	9496758	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr20:9496758C>A	uc002wni.1	+	3	578	c.349C>A	c.(349-351)CTC>ATC	p.L117I	C20orf103_uc010zrc.1_Intron	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	117	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			CGCATATGCACTCAAAATGCT	0.617			NA											10	14					4.3838e-07	5.63828e-07	0.001855	1	0
KIAA1755	85449	broad.mit.edu	37	20	36869019	36869019	+	Missense_Mutation	SNP	G	G	T	rs144867582		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr20:36869019G>T	uc002xhy.1	-	3	1786	c.1514C>A	c.(1513-1515)TCT>TAT	p.S505Y	KIAA1755_uc002xhz.1_Missense_Mutation_p.S505Y	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	505										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGGTTTAGGAGAGTAGAGGGA	0.502			NA											39	83					7.04047e-22	1.14723e-21	0.005524	1	0
EYA2	2139	broad.mit.edu	37	20	45702913	45702913	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr20:45702913C>A	uc002xsm.2	+	7	974	c.600C>A	c.(598-600)TCC>TCA	p.S200S	EYA2_uc010ghp.2_Silent_p.S200S|EYA2_uc002xsn.2_Silent_p.S205S|EYA2_uc002xso.2_Silent_p.S200S|EYA2_uc002xsp.2_Silent_p.S200S|EYA2_uc002xsq.2_Silent_p.S200S	NM_005244	NP_005235	O00167	EYA2_HUMAN	eyes absent 2 isoform a	200					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			ovary(1)	1		Myeloproliferative disorder(115;0.0241)				TCTCCACGTCCACCTACGTCC	0.617	Pancreas(120;56 1725 18501 25218 43520)		NA											19	40					1.96292e-10	2.79734e-10	0.010504	1	0
CTCFL	140690	broad.mit.edu	37	20	56099046	56099046	+	Silent	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr20:56099046C>G	uc010gix.1	-	1	878	c.216G>C	c.(214-216)TCG>TCC	p.S72S	CTCFL_uc010giw.1_Silent_p.S72S|CTCFL_uc002xym.2_Silent_p.S72S|CTCFL_uc010giz.1_Intron|CTCFL_uc010giy.1_Intron|CTCFL_uc010gja.1_Silent_p.S72S|CTCFL_uc010gjb.1_Silent_p.S72S|CTCFL_uc010gjc.1_Silent_p.S72S|CTCFL_uc010gjd.1_Silent_p.S72S|CTCFL_uc010gje.2_Silent_p.S72S|CTCFL_uc010gjf.2_Intron|CTCFL_uc010gjg.2_Intron|CTCFL_uc010gjh.1_Silent_p.S72S|CTCFL_uc010gji.1_Intron|CTCFL_uc010gjj.1_Silent_p.S72S|CTCFL_uc010gjk.1_Silent_p.S72S|CTCFL_uc010gjl.1_Silent_p.S72S	NM_080618	NP_542185	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor-like protein	72					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|skin(1)	4	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			CGCTCTCCTCCGAGGGGGCCA	0.587			NA											37	63					0	0	0.003755	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61910347	61910347	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr20:61910347G>T	uc002yem.2	+	7	739	c.627G>T	c.(625-627)TCG>TCT	p.S209S	ARFGAP1_uc011aas.1_Silent_p.S156S|ARFGAP1_uc011aat.1_Silent_p.S96S|ARFGAP1_uc002yel.2_Silent_p.S209S|ARFGAP1_uc002yen.2_Silent_p.S209S	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	209					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					CCCTGTACTCGGTGAGGACTT	0.612			NA											8	19					5.18039e-06	6.34365e-06	0.00308	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253584	32253584	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr21:32253584C>G	uc002yov.2	-	1	291	c.260G>C	c.(259-261)CGA>CCA	p.R87P		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	87						keratin filament	structural molecule activity			pancreas(1)	1						GGTAGTTTGTCGAGAGCAAGT	0.562			NA											3	31					0	0	0.009096	0	0
COL6A1	1291	broad.mit.edu	37	21	47423462	47423462	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr21:47423462G>T	uc002zhu.1	+	35	2724	c.2622G>T	c.(2620-2622)GCG>GCT	p.A874A	COL6A1_uc010gqd.1_Silent_p.A205A|COL6A1_uc002zhv.1_Silent_p.A205A|COL6A1_uc002zhw.1_5'UTR	NM_001848	NP_001839	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1 precursor	874	C-terminal globular domain.|VWFA 3.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			ovary(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	TGCGGGTGGCGGTGGTGCAGT	0.697			NA											10	25					1.11149e-13	1.67132e-13	0.008291	1	0
SEZ6L	23544	broad.mit.edu	37	22	26747161	26747161	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr22:26747161C>A	uc003acb.2	+	12	2707	c.2551C>A	c.(2551-2553)CGT>AGT	p.R851S	SEZ6L_uc003acc.2_Missense_Mutation_p.R851S|SEZ6L_uc011akc.1_Missense_Mutation_p.R851S|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Missense_Mutation_p.R851S|SEZ6L_uc003ace.2_Missense_Mutation_p.R851S|SEZ6L_uc003acf.1_Missense_Mutation_p.R624S|SEZ6L_uc010gvc.1_Missense_Mutation_p.R624S|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	851	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						CTGCTACAGCCGTGAAACAGG	0.532			NA											19	43					1.10923e-09	1.5224e-09	0.00278	1	0
TTLL8	164714	broad.mit.edu	37	22	50485615	50485615	+	Silent	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr22:50485615T>A	uc011ark.1	-	4	375	c.375A>T	c.(373-375)ACA>ACT	p.T125T		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		TGAAGGAGGCTGTCTTTGCGT	0.582			NA											5	23					0	0	0.000602	0	0
SRGAP3	9901	broad.mit.edu	37	3	9032338	9032338	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:9032338G>A	uc003brf.1	-	21	3420	c.2744C>T	c.(2743-2745)GCG>GTG	p.A915V	SRGAP3_uc003brg.1_Missense_Mutation_p.A891V	NM_014850	NP_055665	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	915					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(4)	central_nervous_system(4)|skin(3)|urinary_tract(1)|breast(1)	9				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CCCGAACGTCGCCATCCTCCG	0.652			NA	T	RAF1	pilocytic astrocytoma								5	12					0	0	0.000602	0	0
ATP2B2	491	broad.mit.edu	37	3	10444022	10444022	+	Silent	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:10444022C>G	uc003bvt.2	-	4	847	c.408G>C	c.(406-408)ACG>ACC	p.T136T	ATP2B2_uc003bvv.2_Silent_p.T136T|ATP2B2_uc003bvw.2_Silent_p.T136T|ATP2B2_uc010hdp.2_Silent_p.T136T|ATP2B2_uc010hdo.2_5'UTR	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	136	Extracellular (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CACCCTGGGCCGTCGCACATC	0.582	Ovarian(125;1619 1709 15675 19819 38835)		NA											34	73					0	0	0.002836	0	0
ZNF662	389114	broad.mit.edu	37	3	42949613	42949613	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:42949613G>A	uc003cmi.2	+	2	359	c.7G>A	c.(7-9)GAG>AAG	p.E3K	ZNF662_uc003cmk.2_Missense_Mutation_p.E64K|ZNF662_uc003cmj.2_5'UTR	NM_207404	NP_997287	Q6ZS27	ZN662_HUMAN	zinc finger protein 662 isoform 1	3	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(284;0.217)		TGTGATGCTGGAGAATTATGG	0.567			NA											7	25					0	0	0.00308	0	0
UQCRC1	7384	broad.mit.edu	37	3	48646610	48646610	+	Silent	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:48646610A>G	uc003cub.1	-	2	240	c.195T>C	c.(193-195)TCT>TCC	p.S65S	UQCRC1_uc003cuc.1_Silent_p.S65S|UQCRC1_uc003cud.1_Silent_p.S65S	NM_003365	NP_003356	P31930	QCR1_HUMAN	ubiquinol-cytochrome c reductase core protein I	65					aerobic respiration|proteolysis		metalloendopeptidase activity|ubiquinol-cytochrome-c reductase activity|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)	Atovaquone(DB01117)	AAGTGGGCTGAGAGGACTGCT	0.647	NSCLC(81;1112 1427 27031 32409 45529)		NA											16	21					0	0	0.006122	0	0
BSN	8927	broad.mit.edu	37	3	49699759	49699759	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:49699759G>T	uc003cxe.3	+	6	10595	c.10481G>T	c.(10480-10482)CGA>CTA	p.R3494L		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	3494					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		AGCCGGGTACGACCCCCCATG	0.687			NA											3	22					0.004672	0.00500222	0.004672	1	0
CNTN3	5067	broad.mit.edu	37	3	74350822	74350822	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:74350822C>A	uc003dpm.1	-	14	2001	c.1921G>T	c.(1921-1923)GTG>TTG	p.V641L		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	641	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TGCCAACCCACGGAGAAAGGT	0.448			NA											17	40					2.94398e-08	3.90938e-08	0.007413	1	0
CNTN3	5067	broad.mit.edu	37	3	74350861	74350861	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:74350861C>G	uc003dpm.1	-	14	1962	c.1882G>C	c.(1882-1884)GTT>CTT	p.V628L		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	628	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		TAGGATATAACTGGGCTATGG	0.463			NA											10	55					0	0	0.008291	0	0
CASR	846	broad.mit.edu	37	3	122003983	122003983	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:122003983G>A	uc003eev.3	+	7	3554	c.3182G>A	c.(3181-3183)AGC>AAC	p.S1061N	CASR_uc003eew.3_Missense_Mutation_p.S1071N	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	1061	Cytoplasmic (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGTTCACAGAGCTTTGTCATC	0.517			NA											30	70					0	0	0.002836	0	0
PLCH1	23007	broad.mit.edu	37	3	155199813	155199813	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:155199813C>A	uc011bok.1	-	23	4303	c.4026G>T	c.(4024-4026)GAG>GAT	p.E1342D	PLCH1_uc011boj.1_3'UTR|PLCH1_uc011bol.1_Missense_Mutation_p.E1304D	NM_001130960	NP_001124432	Q4KWH8	PLCH1_HUMAN	phospholipase C eta 1 isoform a	1342					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(3)|ovary(1)	4			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CTATTACATCCTCCAGGGTCA	0.468			NA											6	61					5.9392e-07	7.61484e-07	0.001168	1	0
ARL14	80117	broad.mit.edu	37	3	160395577	160395577	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:160395577A>G	uc003fdq.2	+	1	630	c.443A>G	c.(442-444)GAC>GGC	p.D148G		NM_025047	NP_079323	Q8N4G2	ARL14_HUMAN	ADP-ribosylation factor-like 14	148					small GTPase mediated signal transduction	intracellular	GTP binding				0			Lung(72;7.02e-05)|LUSC - Lung squamous cell carcinoma(72;7.23e-05)			CTTTGCAGTGACCGGAACTGG	0.498			NA											21	52					0	0	0.002299	0	0
SI	6476	broad.mit.edu	37	3	164766917	164766917	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr3:164766917C>A	uc003fei.2	-	15	1775	c.1713G>T	c.(1711-1713)GAG>GAT	p.E571D		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	571	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCACTTACTGCTCTGTGGCTA	0.328			NA								HNSCC(35;0.089)			6	53					8.12818e-05	9.33828e-05	0.001984	1	0
CPZ	8532	broad.mit.edu	37	4	8616159	8616159	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:8616159C>T	uc003glm.2	+	9	1563	c.1437C>T	c.(1435-1437)CCC>CCT	p.P479P	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Silent_p.P342P|CPZ_uc003glo.2_Silent_p.P468P|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	479					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						TGAAGTTCCCCCCCGAGGAGG	0.572			NA											7	27					0	0	0.001984	0	0
BOD1L	259282	broad.mit.edu	37	4	13588025	13588025	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:13588025T>A	uc003gmz.1	-	17	8545	c.8428A>T	c.(8428-8430)ACA>TCA	p.T2810S		NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2810							DNA binding			ovary(5)|breast(1)	6						AATACCTTTGTGTCATGTGGC	0.363			NA											19	47					0	0	0.001882	0	0
SLIT2	9353	broad.mit.edu	37	4	20597397	20597397	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:20597397A>C	uc003gpr.1	+	31	3464	c.3260A>C	c.(3259-3261)AAC>ACC	p.N1087T	SLIT2_uc003gps.1_Missense_Mutation_p.N1079T	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1087	EGF-like 5; calcium-binding (Potential).				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						AAGTGTAAAAACGGAGCCCAC	0.423			NA											11	110					0	0	0.000978	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23814445	23814445	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:23814445T>G	uc003gqs.2	-	10	2064	c.1944A>C	c.(1942-1944)GAA>GAC	p.E648D	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	648					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				TGCGATATTCTTCCCTCTTCA	0.463	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											16	191					0	0	0.006122	0	0
PCDH7	5099	broad.mit.edu	37	4	30725632	30725632	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:30725632A>T	uc003gsk.1	+	1	3596	c.2588A>T	c.(2587-2589)CAG>CTG	p.Q863L	PCDH7_uc011bxw.1_Missense_Mutation_p.Q816L|PCDH7_uc011bxx.1_Missense_Mutation_p.Q863L	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	863	Extracellular (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CCACTCACCCAGGATATAGCT	0.448			NA											16	50					0	0	0.004007	0	0
SLAIN2	57606	broad.mit.edu	37	4	48381723	48381723	+	Silent	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:48381723A>G	uc003gya.3	+	4	864	c.720A>G	c.(718-720)TCA>TCG	p.S240S	SLAIN2_uc003gyb.1_5'Flank	NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	240						centrosome					0						TGAAAAGCTCAGACAGAAATC	0.313			NA											10	60					0	0	0.006214	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68934421	68934421	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:68934421G>T	uc003hdt.1	-	7	719	c.670C>A	c.(670-672)CTC>ATC	p.L224I	LOC550112_uc003hdl.3_Intron|uc011cak.1_Intron	NM_207407	NP_997290	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	224	Peptidase S1.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						ATGAGCTGGAGGCTGGCCTGC	0.507			NA											10	57					2.74318e-10	3.86883e-10	0.006214	1	0
YTHDC1	91746	broad.mit.edu	37	4	69197847	69197847	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:69197847C>A	uc003hdx.2	-	7	1449	c.1096G>T	c.(1096-1098)GAG>TAG	p.E366*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.E348*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	366	YTH.									upper_aerodigestive_tract(1)|ovary(1)	2						GACACATTCTCATGGTTGTTA	0.318			NA											11	62					1.15088e-07	1.49431e-07	0.004007	1	0
UGT2B28	54490	broad.mit.edu	37	4	70160247	70160247	+	Splice_Site	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:70160247G>C	uc003hej.2	+	6	1313	c.1311_splice	c.e6-1	p.S437_splice	UGT2B28_uc010ihr.2_Splice_Site_p.I335_splice	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,						xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TTATCCTTCAGATATAAAGAG	0.333			NA											12	76					0	0	0.003163	0	0
MUC7	4589	broad.mit.edu	37	4	71347269	71347269	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:71347269G>T	uc011cat.1	+	4	1096	c.808G>T	c.(808-810)GAC>TAC	p.D270Y	MUC7_uc011cau.1_Missense_Mutation_p.D270Y|MUC7_uc003hfj.2_Missense_Mutation_p.D270Y|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	270	Thr-rich.|5.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			AACTACCCTAGACCCATCATC	0.592			NA											15	119					1.15088e-07	1.49431e-07	0.004007	1	0
CCDC158	339965	broad.mit.edu	37	4	77305770	77305770	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:77305770T>C	uc003hkb.3	-	4	490	c.337A>G	c.(337-339)ATT>GTT	p.I113V	CCDC158_uc003hkd.2_Missense_Mutation_p.I113V	NM_001042784	NP_001036249	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	113	Potential.									skin(3)|ovary(2)|pancreas(1)	6						TGCAAATCAATGACTGACTGC	0.333			NA											42	126					0	0	0.009718	0	0
FRAS1	80144	broad.mit.edu	37	4	79373507	79373507	+	Silent	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:79373507A>T	uc003hlb.2	+	47	7202	c.6762A>T	c.(6760-6762)CCA>CCT	p.P2254P		NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2253	CSPG 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						CAGCATCACCAGGTAAGTCTA	0.463			NA											4	16					0	0	0.009096	0	0
WDFY3	23001	broad.mit.edu	37	4	85660237	85660237	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:85660237C>A	uc003hpd.2	-	40	6908	c.6500G>T	c.(6499-6501)CGC>CTC	p.R2167L		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2167						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TGTGGTCATGCGGGCTTCTGC	0.413			NA											12	79					3.27435e-08	4.30614e-08	0.00245	1	0
MEPE	56955	broad.mit.edu	37	4	88766342	88766342	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:88766342A>T	uc003hqy.2	+	4	361	c.322A>T	c.(322-324)ACT>TCT	p.T108S	MEPE_uc010ikn.2_5'UTR	NM_020203	NP_064588	Q9NQ76	MEPE_HUMAN	matrix, extracellular phosphoglycoprotein with	108					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			ovary(1)|lung(1)|skin(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		CAAAGAGAATACTCACAATGG	0.358			NA											27	72					0	0	0.008361	0	0
USP53	54532	broad.mit.edu	37	4	120170028	120170029	+	Nonsense_Mutation	DNP	GG	GG	CT	rs144065914	by1000genomes	TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:120170028_120170029GG>CT	uc003ics.3	+	6	1429_1430	c.363_364GG>CT	c.(361-366)GCGGAG>GCCTAG	p.E122*	USP53_uc003icr.3_Nonsense_Mutation_p.E122*|USP53_uc003icu.3_5'UTR	NM_019050	NP_061923	Q70EK8	UBP53_HUMAN	ubiquitin specific protease 53	122					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			ovary(1)|breast(1)|kidney(1)|skin(1)	4						ATGATGCTGCGGAGTGCTTTGT	0.386			NA											14	130					0	0	0.004672	0	0
INTU	27152	broad.mit.edu	37	4	128584607	128584607	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:128584607G>A	uc003ifk.1	+	4	910	c.840G>A	c.(838-840)CAG>CAA	p.Q280Q	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	280										ovary(1)	1						AAAAGACACAGTCCAACACAA	0.393			NA											26	44					0	0	0.004656	0	0
DCHS2	54798	broad.mit.edu	37	4	155155900	155155900	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:155155900C>A	uc003inw.2	-	25	8539	c.8539G>T	c.(8539-8541)GGG>TGG	p.G2847W		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2847					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGCACCTGCCCCAGGTTTACT	0.498			NA											19	177					5.03518e-11	7.25137e-11	0.007413	1	0
DCHS2	54798	broad.mit.edu	37	4	155155902	155155902	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:155155902A>G	uc003inw.2	-	25	8537	c.8537T>C	c.(8536-8538)CTG>CCG	p.L2846P		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2846					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CACCTGCCCCAGGTTTACTGC	0.507			NA											20	188					0	0	0.008871	0	0
HPGD	3248	broad.mit.edu	37	4	175443105	175443105	+	Silent	SNP	T	T	C	rs146392763		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:175443105T>C	uc003itu.2	-	2	397	c.207A>G	c.(205-207)CAA>CAG	p.Q69Q	HPGD_uc003itv.2_Silent_p.Q69Q|HPGD_uc011ckf.1_5'UTR|HPGD_uc010irp.2_Intron|HPGD_uc010irq.2_Silent_p.Q69Q|HPGD_uc011ckg.1_Silent_p.Q69Q|HPGD_uc011ckh.1_5'UTR|HPGD_uc003itw.2_Silent_p.Q69Q|HPGD_uc003itx.2_Silent_p.Q69Q	NM_000860	NP_000851	P15428	PGDH_HUMAN	hydroxyprostaglandin dehydrogenase 15-(NAD)	69					female pregnancy|lipoxygenase pathway|negative regulation of cell cycle|parturition|prostaglandin metabolic process|transforming growth factor beta receptor signaling pathway	cytosol|nucleus	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|NAD+ binding|prostaglandin E receptor activity|protein homodimerization activity				0		Prostate(90;0.00763)|Melanoma(52;0.0179)|Renal(120;0.0376)|Breast(14;0.0991)|all_hematologic(60;0.124)|all_neural(102;0.196)		all cancers(43;2.6e-18)|Epithelial(43;4.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.23e-09)|GBM - Glioblastoma multiforme(59;0.00176)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.0253)	NADH(DB00157)	CTCTCAGTTGTTGCTGGTCAG	0.537			NA											18	164					0	0	0.001882	0	0
WDR17	116966	broad.mit.edu	37	4	177061073	177061073	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:177061073T>A	uc003iuj.2	+	11	1618	c.1462T>A	c.(1462-1464)TGG>AGG	p.W488R	WDR17_uc003iuk.2_Missense_Mutation_p.W464R|WDR17_uc003ium.3_Missense_Mutation_p.W464R|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	488	WD 8.									ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		CTGCATTGCCTGGAGTCATAA	0.303			NA											23	152					0	0	0.008361	0	0
KIAA0947	23379	broad.mit.edu	37	5	5486895	5486895	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:5486895G>T	uc003jdm.3	+	18	6804	c.6582G>T	c.(6580-6582)TCG>TCT	p.S2194S		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2194										ovary(1)|central_nervous_system(1)	2						ATATTAGTTCGGTTATTGGTA	0.328			NA											20	7					1.87028e-06	2.36825e-06	0.001882	1	0
TRIO	7204	broad.mit.edu	37	5	14364019	14364019	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:14364019A>G	uc003jff.2	+	14	2576	c.2570A>G	c.(2569-2571)AAT>AGT	p.N857S	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.N808S|TRIO_uc003jfh.1_Missense_Mutation_p.N506S	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	857					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					CAGTATGTCAATGAGGTCCAG	0.507			NA											9	81					0	0	0.004482	0	0
PRDM9	56979	broad.mit.edu	37	5	23526524	23526524	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:23526524G>A	uc003jgo.2	+	11	1509	c.1327G>A	c.(1327-1329)GAT>AAT	p.D443N		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	443					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GCAATATCCAGATCCACACAG	0.473			NA								HNSCC(3;0.000094)			7	112					0	0	0.00308	0	0
PRDM9	56979	broad.mit.edu	37	5	23526569	23526569	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:23526569G>T	uc003jgo.2	+	11	1554	c.1372G>T	c.(1372-1374)GAA>TAA	p.E458*		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	458					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AGAGATCAAAGAAAGGTCCAA	0.483			NA								HNSCC(3;0.000094)			6	59					8.12818e-05	9.33828e-05	0.001984	1	0
PRDM9	56979	broad.mit.edu	37	5	23526586	23526586	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:23526586G>A	uc003jgo.2	+	11	1571	c.1389G>A	c.(1387-1389)TTG>TTA	p.L463L		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	463					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						CCAAACTCTTGAATAAAAGGA	0.463			NA								HNSCC(3;0.000094)			5	56					0	0	0.001168	0	0
PRDM9	56979	broad.mit.edu	37	5	23526601	23526601	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:23526601G>A	uc003jgo.2	+	11	1586	c.1404G>A	c.(1402-1404)TGG>TGA	p.W468*		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	468					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						AAAGGACATGGCAGAGGGAGA	0.453			NA								HNSCC(3;0.000094)			6	64					0	0	0.001984	0	0
CDH10	1008	broad.mit.edu	37	5	24487942	24487942	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:24487942G>T	uc003jgr.1	-	12	2529	c.2197C>A	c.(2197-2199)CTT>ATT	p.L733I	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	733	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAGGTTGCAAGTGAGTCGTAG	0.468			NA								HNSCC(23;0.051)			21	314					1.50039e-11	2.1761e-11	0.001882	1	0
IL7R	3575	broad.mit.edu	37	5	35874576	35874576	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:35874576C>A	uc003jjs.2	+	6	821	c.732C>A	c.(730-732)ACC>ACA	p.T244T	IL7R_uc011coo.1_Intron|IL7R_uc011cop.1_Intron	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	244	Helical; (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TCTTACTAACCATCAGCATTT	0.443			NA											12	304					2.68362e-12	3.96246e-12	0.001368	1	0
RICTOR	253260	broad.mit.edu	37	5	38949913	38949913	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:38949913G>C	uc003jlp.2	-	31	4061	c.4037C>G	c.(4036-4038)TCT>TGT	p.S1346C	RICTOR_uc003jlo.2_Missense_Mutation_p.S1346C|RICTOR_uc010ivf.2_Missense_Mutation_p.S1061C	NM_152756	NP_689969	Q6R327	RICTR_HUMAN	rapamycin-insensitive companion of mTOR	1346					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			ovary(3)|lung(3)|skin(2)|kidney(1)|central_nervous_system(1)	10	all_lung(31;0.000396)					TTCAGAGTGAGATAAGGATGG	0.408			NA											13	219					0	0	0.001368	0	0
C6	729	broad.mit.edu	37	5	41142965	41142965	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:41142965T>G	uc003jmk.2	-	18	2977	c.2767A>C	c.(2767-2769)AAG>CAG	p.K923Q	C6_uc003jml.1_Missense_Mutation_p.K923Q	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	923	Complement control factor I module 2.|C5b-binding domain.|Kazal-like 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				ATTTCCATCTTCCTGTTTGCA	0.433			NA											11	191					0	0	0.001855	0	0
SNX18	112574	broad.mit.edu	37	5	53814525	53814525	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:53814525C>T	uc003jpj.3	+	1	933	c.743C>T	c.(742-744)GCG>GTG	p.A248V	SNX18_uc011cqg.1_Missense_Mutation_p.A248V|SNX18_uc003jpi.3_Missense_Mutation_p.A248V	NM_052870	NP_443102	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform b	248					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				CTGGGGGAGGCGTCAGGCTTC	0.672			NA											11	72					0	0	0.001368	0	0
PJA2	9867	broad.mit.edu	37	5	108717348	108717348	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:108717348T>C	uc003kos.3	-	3	308	c.88A>G	c.(88-90)ACA>GCA	p.T30A		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	30					long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		CCTGTAATTGTCTGATACCCT	0.418			NA											10	81					0	0	0.000978	0	0
TRPC7	57113	broad.mit.edu	37	5	135692916	135692916	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:135692916C>A	uc003lbn.1	-	1	160	c.157G>T	c.(157-159)GGC>TGC	p.G53C	TRPC7_uc010jef.1_Missense_Mutation_p.G45C|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.G45C|TRPC7_uc010jei.1_Missense_Mutation_p.G45C|TRPC7_uc010jej.1_5'UTR	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	54	Cytoplasmic (Potential).|ANK 1.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGGATGTTGCCATACTCAGCC	0.622			NA											17	114					6.94344e-10	9.65942e-10	0.006122	1	0
SLC23A1	9963	broad.mit.edu	37	5	138718265	138718265	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:138718265C>T	uc003leh.2	-	2	163	c.66G>A	c.(64-66)CCG>CCA	p.P22P	SLC23A1_uc003leg.2_Silent_p.P22P	NM_005847	NP_005838	Q9UHI7	S23A1_HUMAN	solute carrier family 23 (nucleobase	22					brain development|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|response to toxin|transepithelial L-ascorbic acid transport|water-soluble vitamin metabolic process	apical plasma membrane|cytoplasm|integral to plasma membrane|intracellular organelle|membrane fraction	dehydroascorbic acid transporter activity|L-ascorbate:sodium symporter activity|nucleobase transmembrane transporter activity|protein binding|sodium-dependent L-ascorbate transmembrane transporter activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)		Vitamin C(DB00126)	CTGTGGGTAGCGGGGTCGAGG	0.567			NA											3	47					0	0	0.004672	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215949	140215949	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:140215949G>A	uc003lhq.2	+	1	1981	c.1981G>A	c.(1981-1983)GCC>ACC	p.A661T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.A661T	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	661	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCTGACAGCCACAGCCAC	0.657	NSCLC(160;258 2013 5070 22440 28951)		NA											11	44					0	0	0.000978	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256413	140256413	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:140256413G>T	uc003lic.2	+	1	1483	c.1356G>T	c.(1354-1356)GCG>GCT	p.A452A	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Silent_p.A452A	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	452	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACAATGCGCCTGCGTTCG	0.662	Pancreas(113;759 1672 13322 24104 50104)		NA											14	68					3.27435e-08	4.30614e-08	0.00245	1	0
PCDHB1	29930	broad.mit.edu	37	5	140431512	140431512	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:140431512C>T	uc003lik.1	+	1	534	c.457C>T	c.(457-459)CCT>TCT	p.P153S		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	153	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCACGTTTTCCTCTGCAGAG	0.527			NA											8	31					0	0	0.006214	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482154	140482154	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:140482154G>A	uc003lio.2	+	1	1921	c.1921G>A	c.(1921-1923)GTG>ATG	p.V641M	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	641	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCACAGGCTGGTGGTGCTGGT	0.701			NA											6	44					0	0	0.001168	0	0
PCDHB13	56123	broad.mit.edu	37	5	140594897	140594897	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:140594897A>G	uc003lja.1	+	1	1389	c.1202A>G	c.(1201-1203)TAC>TGC	p.Y401C		NM_018933	NP_061756	Q9Y5F0	PCDBD_HUMAN	protocadherin beta 13 precursor	401	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAAACTTTTACACCCTACTA	0.448			NA											6	48					0	0	0.001984	0	0
FAM71B	153745	broad.mit.edu	37	5	156592624	156592624	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:156592624G>T	uc003lwn.2	-	1	656	c.556C>A	c.(556-558)CCA>ACA	p.P186T		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	186						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAAGTGTTGGGGTACTGCAG	0.512			NA											40	223					4.92203e-23	8.11737e-23	0.00623	1	0
ATP10B	23120	broad.mit.edu	37	5	160061467	160061467	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:160061467G>T	uc003lym.1	-	12	2122	c.1275C>A	c.(1273-1275)GGC>GGA	p.G425G	ATP10B_uc003lyp.2_Silent_p.G425G|ATP10B_uc011deg.1_Silent_p.G469G|ATP10B_uc003lyn.2_5'UTR|ATP10B_uc003lyo.2_Silent_p.G397G	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	425	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACTGGATCTGGCCCAAGTCCT	0.502			NA											22	94					2.39556e-15	3.68341e-15	0.00278	1	0
DOCK2	1794	broad.mit.edu	37	5	169186763	169186763	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:169186763G>C	uc003maf.2	+	24	2511	c.2431G>C	c.(2431-2433)GAT>CAT	p.D811H	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.D303H	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	811					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AATGGTCTTTGATGCGAAGTT	0.468			NA											13	84					0	0	0.003163	0	0
DOCK2	1794	broad.mit.edu	37	5	169446013	169446013	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:169446013G>A	uc003maf.2	+	33	3362	c.3282G>A	c.(3280-3282)GAG>GAA	p.E1094E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Silent_p.E586E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1094	Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTATATTAGAGATGACACTTA	0.453			NA											33	210					0	0	0.002836	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178541268	178541268	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:178541268T>C	uc003mjw.2	-	22	3236	c.3236A>G	c.(3235-3237)TAT>TGT	p.Y1079C	uc003mjv.3_5'Flank	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1079	PLAC.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GATGGAGCAATAGCGGGACAA	0.502			NA											5	22					0	0	0.001168	0	0
BTNL3	10917	broad.mit.edu	37	5	180419856	180419856	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:180419856G>T	uc003mmr.2	+	2	221	c.93G>T	c.(91-93)TTG>TTT	p.L31F		NM_197975	NP_932079	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3 precursor	31	Extracellular (Potential).				lipid metabolic process	integral to membrane					0	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			TCCAGGCCTTGGTGGGGGAGG	0.542			NA											10	21					0.00136819	0.00149623	0.001368	1	0
ATXN1	6310	broad.mit.edu	37	6	16328216	16328216	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:16328216G>A	uc003nbt.2	-	8	1297	c.326C>T	c.(325-327)CCG>CTG	p.P109L	ATXN1_uc010jpi.2_Missense_Mutation_p.P109L|ATXN1_uc010jpj.1_Intron	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	109					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				CCCTGGCTGCGGGGTGGCGTA	0.647			NA											14	56					0	0	0.00245	0	0
RBM24	221662	broad.mit.edu	37	6	17292081	17292081	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:17292081C>A	uc003nbz.3	+	4	446	c.442C>A	c.(442-444)CCT>ACT	p.P148T	RBM24_uc003nby.3_3'UTR|RBM24_uc011dix.1_Missense_Mutation_p.P90T|RBM24_uc003nca.2_Missense_Mutation_p.P103T|RBM24_uc011diy.1_Silent_p.P61P|RBM24_uc011diz.1_Silent_p.P46P	NM_001143942	NP_001137414	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24 isoform 1	148	Ala-rich.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			ovary(1)|skin(1)	2	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			CTCCACCACCCCTTACATTGA	0.478			NA											14	90					4.36969e-10	6.09967e-10	0.001855	1	0
TRIM39	56658	broad.mit.edu	37	6	30309955	30309955	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:30309955G>T	uc010jrz.2	+	9	1788	c.1476G>T	c.(1474-1476)TGG>TGT	p.W492C	TRIM39_uc003npz.2_Missense_Mutation_p.W462C|TRIM39_uc003nqb.2_Missense_Mutation_p.W462C|TRIM39_uc003nqc.2_Missense_Mutation_p.W462C|TRIM39_uc010jsa.1_Intron|RPP21_uc003nqd.1_5'Flank|RPP21_uc003nqe.1_5'Flank|RPP21_uc003nqf.1_5'Flank	NM_021253	NP_067076	Q9HCM9	TRI39_HUMAN	tripartite motif-containing 39 isoform 1	492	B30.2/SPRY.				apoptosis	cytosol|mitochondrion	identical protein binding|zinc ion binding			ovary(3)	3						AGAAACTTTGGCCCCTCTTCT	0.507			NA											8	34					3.09899e-07	3.99838e-07	0.004482	1	0
TMEM217	221468	broad.mit.edu	37	6	37186304	37186304	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:37186304C>G	uc003onl.2	-	2	584	c.503G>C	c.(502-504)CGA>CCA	p.R168P	TMEM217_uc010jwr.2_Missense_Mutation_p.R168P|TMEM217_uc010jws.2_Intron|TMEM217_uc003onm.3_Missense_Mutation_p.R168P	NM_145316	NP_660359	Q8N7C4	TM217_HUMAN	transmembrane protein 217 isoform 1	168						integral to membrane					0						TGTAGAAATTCGTCTCTTGTA	0.313			NA											25	138					0	0	0.007291	0	0
CUL7	9820	broad.mit.edu	37	6	43018826	43018826	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:43018826C>G	uc003otq.2	-	4	1416	c.1113G>C	c.(1111-1113)TTG>TTC	p.L371F	CUL7_uc011dvb.1_Missense_Mutation_p.L455F|CUL7_uc010jyh.2_Intron|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	371	Interaction with TP53.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CCCGCACATACAAAGCATAGG	0.592			NA											26	49					0	0	0.003954	0	0
ZNF318	24149	broad.mit.edu	37	6	43307502	43307502	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:43307502C>T	uc003oux.2	-	10	4312	c.4234G>A	c.(4234-4236)GGG>AGG	p.G1412R	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1412					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ACCTCTTCCCCTCCAAATGCT	0.413			NA											13	64					0	0	0.001368	0	0
TDRD6	221400	broad.mit.edu	37	6	46660740	46660740	+	Silent	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:46660740G>C	uc003oyj.2	+	1	4875	c.4875G>C	c.(4873-4875)CTG>CTC	p.L1625L	TDRD6_uc010jze.2_Silent_p.L1619L	NM_001010870	NP_001010870	O60522	TDRD6_HUMAN	tudor domain containing 6	1625	Tudor 7.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			breast(3)|ovary(2)|skin(1)	6			Lung(136;0.192)			CTGAACTTCTGTCGGTTCCCA	0.408			NA											28	117					0	0	0.002445	0	0
PRIM2	5558	broad.mit.edu	37	6	57398139	57398139	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:57398139C>T	uc003pdx.2	+	10	929	c.842C>T	c.(841-843)ACC>ATC	p.T281I		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	281					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		TAGCTTTCTACCAAATCCTTC	0.368			NA											21	113					0	0	0.001882	0	0
BCKDHB	594	broad.mit.edu	37	6	80838877	80838877	+	Splice_Site	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:80838877G>T	uc003pjd.2	+	3	342	c.275_splice	c.e3-1	p.V92_splice	BCKDHB_uc003pje.2_Splice_Site_p.V92_splice	NM_000056	NP_000047	P21953	ODBB_HUMAN	branched chain keto acid dehydrogenase E1 beta						branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxy-lyase activity|protein binding				0		all_cancers(76;1.38e-05)|Acute lymphoblastic leukemia(125;1.15e-05)|all_hematologic(105;0.00118)|all_epithelial(107;0.0149)		BRCA - Breast invasive adenocarcinoma(397;0.0291)		CTGTTTTTCAGTAATATTTGG	0.254			NA											16	56					1.15088e-07	1.49431e-07	0.004007	1	0
MED23	9439	broad.mit.edu	37	6	131943063	131943063	+	Silent	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:131943063T>A	uc003qcs.1	-	6	627	c.453A>T	c.(451-453)ACA>ACT	p.T151T	MED23_uc003qcq.2_Silent_p.T151T|MED23_uc003qct.1_Silent_p.T151T|MED23_uc011ecb.1_RNA	NM_004830	NP_004821	Q9ULK4	MED23_HUMAN	mediator complex subunit 23 isoform a	151					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		CAGAGCTCACTGTATTAGGAA	0.358			NA											24	107					0	0	0.004656	0	0
VNN2	8875	broad.mit.edu	37	6	133073886	133073886	+	Nonsense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:133073886G>C	uc003qdt.2	-	4	551	c.540C>G	c.(538-540)TAC>TAG	p.Y180*	VNN2_uc003qds.2_5'UTR|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Nonsense_Mutation_p.Y127*	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	180	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		AGTACAGGTGGTACTACAACA	0.403			NA											11	92					0	0	0.000978	0	0
TXLNB	167838	broad.mit.edu	37	6	139598001	139598001	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:139598001T>A	uc011eds.1	-	3	647	c.482A>T	c.(481-483)AAG>ATG	p.K161M		NM_153235	NP_694967	Q8N3L3	TXLNB_HUMAN	taxilin beta	161	Potential.					cytoplasm				large_intestine(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		AAAATCAAACTTTTCTTCCGG	0.343			NA											6	43					0	0	0.001168	0	0
GRM1	2911	broad.mit.edu	37	6	146480615	146480615	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr6:146480615C>A	uc010khw.1	+	3	1302	c.832C>A	c.(832-834)CGA>AGA	p.R278R	GRM1_uc010khu.1_Silent_p.R278R|GRM1_uc010khv.1_Silent_p.R278R|GRM1_uc003qll.2_Silent_p.R278R|GRM1_uc011edz.1_Silent_p.R278R|GRM1_uc011eea.1_Silent_p.R278R	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	278	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GCGCAAACTCCGAGAGAGGCT	0.587			NA											7	44					8.12818e-05	9.33828e-05	0.001984	1	0
MMD2	221938	broad.mit.edu	37	7	4965100	4965100	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:4965100G>T	uc003sno.3	-	2	307	c.111C>A	c.(109-111)GCC>GCA	p.A37A	MMD2_uc003snl.1_RNA|MMD2_uc003snn.3_Silent_p.A37A|MMD2_uc010ksq.2_Silent_p.A37A	NM_001100600	NP_001094070	Q8IY49	PAQRA_HUMAN	monocyte to macrophage	37	Cytoplasmic (Potential).					integral to membrane	receptor activity			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.097)|OV - Ovarian serous cystadenocarcinoma(56;3.4e-14)		TGGCACAGTTGGCCGCATGTT	0.602			NA											11	126					5.50884e-06	6.7057e-06	0.001368	1	0
NOD1	10392	broad.mit.edu	37	7	30492353	30492353	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:30492353C>A	uc003tav.2	-	6	1203	c.680G>T	c.(679-681)GGG>GTG	p.G227V	NOD1_uc010kvs.2_Intron	NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	227	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						GAATTTGACCCCTGCGTCTAG	0.582			NA											7	86					0.00198382	0.00214651	0.001984	1	0
TBX20	57057	broad.mit.edu	37	7	35242211	35242211	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:35242211C>T	uc011kas.1	-	8	1186	c.1175G>A	c.(1174-1176)CGA>CAA	p.R392Q		NM_001077653	NP_001071121	Q9UMR3	TBX20_HUMAN	T-box transcription factor TBX20	392						nucleus	DNA binding			central_nervous_system(1)	1						CATTCCCAGTCGGCTATATGG	0.552			NA											9	34					0	0	0.008291	0	0
VPS41	27072	broad.mit.edu	37	7	38937702	38937702	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:38937702C>T	uc003tgy.2	-	2	75	c.49G>A	c.(49-51)GAT>AAT	p.D17N	VPS41_uc003tgz.2_Missense_Mutation_p.D17N|VPS41_uc010kxn.2_Missense_Mutation_p.D17N	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	17					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TCAGACTCATCTGTAGATTCT	0.428			NA											4	77					0	0	0.009096	0	0
RALA	5898	broad.mit.edu	37	7	39736360	39736360	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:39736360A>G	uc003thd.2	+	4	700	c.400A>G	c.(400-402)AAA>GAA	p.K134E		NM_005402	NP_005393	P11233	RALA_HUMAN	ras related v-ral simian leukemia viral oncogene	134					actin cytoskeleton reorganization|cell cycle|chemotaxis|cytokinesis|exocytosis|interspecies interaction between organisms|membrane raft localization|nerve growth factor receptor signaling pathway|positive regulation of filopodium assembly|Ras protein signal transduction|regulation of exocytosis	cell surface|cleavage furrow|cytosol|midbody|plasma membrane	Edg-2 lysophosphatidic acid receptor binding|GTP binding|GTPase activity			lung(1)|skin(1)	2						TTTAGAAGATAAAAGACAGGT	0.363			NA											22	66					0	0	0.00278	0	0
CCM2	83605	broad.mit.edu	37	7	45104118	45104118	+	Silent	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:45104118G>C	uc003tmo.2	+	4	491	c.345G>C	c.(343-345)CTG>CTC	p.L115L	CCM2_uc003tmn.2_RNA|CCM2_uc003tmp.2_Silent_p.L57L|CCM2_uc003tmq.2_RNA|CCM2_uc003tmr.2_Silent_p.L115L|CCM2_uc011kcb.1_Silent_p.L78L|CCM2_uc011kcc.1_Silent_p.L108L|CCM2_uc003tms.2_Silent_p.L136L	NM_031443	NP_113631	Q9BSQ5	CCM2_HUMAN	cerebral cavernous malformation 2 isoform 2	115	PID.				endothelial tube morphogenesis|integrin-mediated signaling pathway|stress-activated MAPK cascade|vasculogenesis	cytoplasm	protein binding				0						TGCTCAGCCTGTCTGCGTACA	0.582			NA							Familial_Cerebral_Cavernous_Angioma				6	24					0	0	0.001168	0	0
UPP1	7378	broad.mit.edu	37	7	48146550	48146550	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:48146550G>T	uc003toj.2	+	8	1046	c.517G>T	c.(517-519)GGG>TGG	p.G173W	UPP1_uc003tok.2_Missense_Mutation_p.G173W|UPP1_uc003tol.2_Missense_Mutation_p.G173W|UPP1_uc011kch.1_5'UTR|UPP1_uc003ton.2_Missense_Mutation_p.G36W|UPP1_uc003too.2_Missense_Mutation_p.G36W	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	173					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						GATTGTCCTGGGGAAGCGGGT	0.542			NA											12	82					3.07112e-06	3.79482e-06	0.000978	1	0
ZNF107	51427	broad.mit.edu	37	7	64167304	64167304	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:64167304A>T	uc003ttd.2	+	7	1408	c.622A>T	c.(622-624)ATA>TTA	p.I208L	ZNF107_uc003tte.2_Missense_Mutation_p.I208L	NM_016220	NP_057304	Q9UII5	ZN107_HUMAN	zinc finger protein 107	208	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.00948)|all_lung(88;0.0249)				TATACATAAAATAATTCATAC	0.368			NA											10	72					0	0	0.006214	0	0
CRCP	27297	broad.mit.edu	37	7	65610483	65610483	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:65610483A>T	uc003tus.2	+	5	438	c.293A>T	c.(292-294)CAG>CTG	p.Q98L	CRCP_uc003tuv.2_RNA|CRCP_uc011kdw.1_Missense_Mutation_p.Q91L|CRCP_uc003tut.2_Missense_Mutation_p.Q65L|CRCP_uc003tuu.2_Missense_Mutation_p.Q21L	NM_014478	NP_055293	O75575	RPC9_HUMAN	calcitonin gene-related peptide-receptor	98					acrosome reaction|innate immune response|response to virus|transcription from RNA polymerase III promoter	DNA polymerase III complex|nucleus|plasma membrane	calcitonin receptor activity|DNA-directed RNA polymerase activity|nucleotide binding				0						GTGGAGATCCAGCTGGTGAGT	0.562			NA											12	96					0	0	0.001368	0	0
ABCB1	5243	broad.mit.edu	37	7	87133638	87133638	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:87133638C>A	uc003uiz.1	-	29	4182	c.3764G>T	c.(3763-3765)GGC>GTC	p.G1255V	ABCB1_uc011khc.1_Missense_Mutation_p.G1191V	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	1255	Cytoplasmic (Potential).|ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	CTGATGCGTGCCATGCTCCTT	0.502			NA											16	84					3.52763e-06	4.34579e-06	0.00499	1	0
DLX5	1749	broad.mit.edu	37	7	96650229	96650229	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:96650229G>C	uc003uon.2	-	3	897	c.689C>G	c.(688-690)TCC>TGC	p.S230C		NM_005221	NP_005212	P56178	DLX5_HUMAN	distal-less homeobox 5	230					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(1)	1	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GAGCGAGCGGGACGAGCCCTG	0.647			NA											10	41					0	0	0.008291	0	0
MUC17	140453	broad.mit.edu	37	7	100683669	100683669	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:100683669G>C	uc003uxp.1	+	3	9025	c.8972G>C	c.(8971-8973)AGT>ACT	p.S2991T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2991	Extracellular (Potential).|Ser-rich.|48.|59 X approximate tandem repeats.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCATTAACAAGTATGTCTGTC	0.512			NA											41	220					0	0	0.002522	0	0
DOCK4	9732	broad.mit.edu	37	7	111535708	111535708	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:111535708C>T	uc003vfx.2	-	16	1816	c.1547G>A	c.(1546-1548)AGG>AAG	p.R516K	DOCK4_uc003vfy.2_Missense_Mutation_p.R516K|DOCK4_uc003vga.1_Missense_Mutation_p.R121K	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	516	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				TGGAAGAGTCCTACCATCTTC	0.413			NA											67	236					0	0	0.00361	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117417770	117417770	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:117417770C>G	uc003vjf.2	-	8	2665	c.2573G>C	c.(2572-2574)AGC>ACC	p.S858T		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	858	ANK 5.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		AAGCTTGAGGCTGTCCACATT	0.448			NA											10	73					0	0	0.006214	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117432194	117432194	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:117432194G>T	uc003vjf.2	-	4	1148	c.1056C>A	c.(1054-1056)GCC>GCA	p.A352A		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	352										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TACCTGGTCTGGCCATGGTGG	0.498			NA											13	115					1.5842e-08	2.11744e-08	0.001855	1	0
C7orf58	79974	broad.mit.edu	37	7	120765938	120765938	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:120765938G>T	uc003vjq.3	+	9	1573	c.1126G>T	c.(1126-1128)GTG>TTG	p.V376L	C7orf58_uc003vjr.1_Missense_Mutation_p.V376L|C7orf58_uc003vjs.3_Missense_Mutation_p.V376L|C7orf58_uc003vjt.3_Missense_Mutation_p.V156L|C7orf58_uc010lkk.1_Missense_Mutation_p.V156L	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	376						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					GTACCCTGTAGTGCTCCAGGT	0.388			NA											10	56					0.000442599	0.000491911	0.006214	1	0
RNF133	168433	broad.mit.edu	37	7	122338345	122338345	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:122338345T>C	uc003vkj.1	-	1	864	c.628A>G	c.(628-630)ATT>GTT	p.I210V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron	NM_139175	NP_631914	Q8WVZ7	RN133_HUMAN	ring finger protein 133	210	Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			skin(1)	1						AGTCTATGAATGTGATAAAAG	0.398	Colon(198;1778 2057 7449 19869 45985)		NA											16	103					0	0	0.003163	0	0
OR2A1	346528	broad.mit.edu	37	7	144015559	144015559	+	Silent	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:144015559G>A	uc011kud.1	+	1	324	c.324G>A	c.(322-324)CTG>CTA	p.L108L	OR2A9P_uc003wec.1_Intron	NM_001001802	NP_001001802	Q8NGT9	OR2A1_HUMAN	olfactory receptor, family 2, subfamily A,	114	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Melanoma(164;0.14)					GTCTCCTGCTGGTGCTGATGT	0.557			NA											10	76					0	0	0.00499	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325428	150325428	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:150325428C>A	uc003whn.2	-	3	682	c.258G>T	c.(256-258)TGG>TGT	p.W86C	GIMAP6_uc003whm.2_Intron	NM_024711	NP_078987	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	86							GTP binding			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTTCCCAGCCCACTCTCGGC	0.582			NA											24	150					1.66031e-10	2.37435e-10	0.003954	1	0
GIMAP5	55340	broad.mit.edu	37	7	150439764	150439764	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:150439764G>T	uc003whr.1	+	3	889	c.537G>T	c.(535-537)GAG>GAT	p.E179D	GIMAP5_uc010lpu.2_Missense_Mutation_p.E37D	NM_018384	NP_060854	Q96F15	GIMA5_HUMAN	GTPase, IMAP family member 5	179	Cytoplasmic (Potential).					integral to membrane|mitochondrial outer membrane	GTP binding			ovary(1)|central_nervous_system(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGGTGCGGGAGTGTGAGAGAA	0.582			NA											8	106					5.4927e-09	7.38985e-09	0.004482	1	0
XPO7	23039	broad.mit.edu	37	8	21860812	21860812	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:21860812T>C	uc003xaa.3	+	26	3128	c.3026T>C	c.(3025-3027)ATA>ACA	p.I1009T	XPO7_uc010lti.2_Missense_Mutation_p.I1018T|XPO7_uc010ltk.2_Missense_Mutation_p.I1010T	NM_015024	NP_055839	Q9UIA9	XPO7_HUMAN	exportin 7 isoform b	1009					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			ovary(1)|kidney(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		CTTGGCTTGATATTGCTTAAT	0.493			NA											2	13					0	0	0.004672	0	0
ADAM7	8756	broad.mit.edu	37	8	24342845	24342845	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:24342845C>A	uc003xeb.2	+	10	1044	c.931C>A	c.(931-933)CTG>ATG	p.L311M	ADAM7_uc003xec.2_Missense_Mutation_p.L83M	NM_003817	NP_003808	Q9H2U9	ADAM7_HUMAN	a disintegrin and metalloproteinase domain 7	311	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(1)|kidney(1)	5		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		GGGTATGTGCCTGCCCTATTA	0.368			NA											17	89					2.4624e-09	3.33483e-09	0.008871	1	0
DPYSL2	1808	broad.mit.edu	37	8	26513217	26513217	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:26513217G>T	uc003xfb.1	+	14	2064	c.1714G>T	c.(1714-1716)GGC>TGC	p.G572C	DPYSL2_uc003xfa.2_Missense_Mutation_p.G677C|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.G536C	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	572					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		CACCAGCCTGGGCTAGAGCTC	0.537			NA									OREG0018659	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	48					0.000442599	0.000491911	0.006214	1	0
TEX15	56154	broad.mit.edu	37	8	30694594	30694594	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:30694594A>T	uc003xil.2	-	3	8057	c.8057T>A	c.(8056-8058)GTA>GAA	p.V2686E		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	2686										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		AGATGGCTGTACTTCATATGA	0.438			NA											19	88					0	0	0.001882	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66963858	66963858	+	Silent	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:66963858C>T	uc003xvs.1	+	3	367	c.76C>T	c.(76-78)CTG>TTG	p.L26L	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	26	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			AATTCTTGGTCTGCATAAGGG	0.403			NA											16	162					0	0	0.004007	0	0
TRPA1	8989	broad.mit.edu	37	8	72973915	72973915	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:72973915C>A	uc003xza.2	-	7	1064	c.889G>T	c.(889-891)GGT>TGT	p.G297C		NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	297	Cytoplasmic (Potential).|ANK 7.					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TCCACGCTACCAGAATAGGAC	0.428			NA											23	117					2.44723e-14	3.72088e-14	0.004656	1	0
FABP12	646486	broad.mit.edu	37	8	82437306	82437306	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:82437306G>T	uc011lfp.1	-	4	398	c.398C>A	c.(397-399)TCA>TAA	p.S133*	FABP12_uc003ycg.3_RNA	NM_001105281	NP_001098751	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	133							lipid binding|transporter activity				0						TGAGTTTGATGATACTTTCTC	0.323			NA											4	15					0.00024832	0.000279019	0.009096	1	0
CA2	760	broad.mit.edu	37	8	86385979	86385979	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:86385979G>T	uc003ydk.2	+	3	470	c.290G>T	c.(289-291)TGG>TTG	p.W97L		NM_000067	NP_000058	P00918	CAH2_HUMAN	carbonic anhydrase II	97					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(1)	1					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CACTTTCACTGGGGTTCACTT	0.318			NA											18	131					7.45023e-12	1.08439e-11	0.010504	1	0
MMP16	4325	broad.mit.edu	37	8	89209452	89209452	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:89209452G>T	uc003yeb.3	-	2	498	c.216C>A	c.(214-216)GCC>GCA	p.A72A	MMP16_uc003yec.2_Silent_p.A72A	NM_005941	NP_005932	P51512	MMP16_HUMAN	matrix metalloproteinase 16 isoform 1	72					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)|urinary_tract(1)|skin(1)|kidney(1)	8						TGGCAGCTAGGGCAGACTGCA	0.473			NA											9	71					7.48243e-07	9.50408e-07	0.006214	1	0
RUNX1T1	862	broad.mit.edu	37	8	92999139	92999139	+	Silent	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:92999139T>G	uc003yfd.2	-	7	1137	c.1053A>C	c.(1051-1053)GCA>GCC	p.A351A	RUNX1T1_uc003yfc.1_Silent_p.A324A|RUNX1T1_uc003yfe.1_Silent_p.A314A|RUNX1T1_uc010mao.2_Silent_p.A324A|RUNX1T1_uc011lgi.1_Silent_p.A362A|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Silent_p.A314A	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	351	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TCCACTCTTCTGCCCATTCTC	0.368			NA											16	237					0	0	0.00499	0	0
KIAA1429	25962	broad.mit.edu	37	8	95531312	95531312	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:95531312T>A	uc003ygo.1	-	9	2427	c.2414A>T	c.(2413-2415)AAT>ATT	p.N805I	KIAA1429_uc003ygp.2_Missense_Mutation_p.N805I|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	805					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCCCACAGGATTAAAAGTAAT	0.408			NA											56	81					0	0	0.00361	0	0
RIMS2	9699	broad.mit.edu	37	8	104897787	104897787	+	Nonsense_Mutation	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:104897787C>G	uc003yls.2	+	2	535	c.294C>G	c.(292-294)TAC>TAG	p.Y98*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.Y320*|RIMS2_uc003ylw.2_Nonsense_Mutation_p.Y128*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.Y128*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.Y128*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	351					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGATGAATACGAAAGGCAAA	0.428			NA								HNSCC(12;0.0054)			14	37					0	0	0.001855	0	0
CSMD3	114788	broad.mit.edu	37	8	114326964	114326964	+	Silent	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:114326964A>T	uc003ynu.2	-	2	396	c.237T>A	c.(235-237)CCT>CCA	p.P79P	CSMD3_uc003ynt.2_Silent_p.P39P|CSMD3_uc011lhx.1_Silent_p.P79P|CSMD3_uc010mcx.1_Silent_p.P79P|CSMD3_uc003ynx.3_Silent_p.P79P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	79	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATGGAAAACCAGGGCTTTCTA	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	181					0	0	0.001882	0	0
CSMD3	114788	broad.mit.edu	37	8	114448956	114448956	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:114448956C>A	uc003ynu.2	-	1	287	c.128G>T	c.(127-129)GGA>GTA	p.G43V	CSMD3_uc011lhx.1_Missense_Mutation_p.G43V|CSMD3_uc010mcx.1_Missense_Mutation_p.G43V|CSMD3_uc003ynx.3_Missense_Mutation_p.G43V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	43	Helical; (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAACGTAAATCCACTTTTAAT	0.502			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	199					1.10923e-09	1.5224e-09	0.00278	1	0
TNFRSF11B	4982	broad.mit.edu	37	8	119936780	119936780	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:119936780G>T	uc003yon.3	-	5	1362	c.1039C>A	c.(1039-1041)CAC>AAC	p.H347N		NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	347	Death 2.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			TTTAGTGCGTGCATTAGGCCC	0.438			NA											53	217					6.3008e-33	1.05616e-32	0.00361	1	0
FER1L6	654463	broad.mit.edu	37	8	125052164	125052164	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:125052164C>A	uc003yqw.2	+	20	2712	c.2506C>A	c.(2506-2508)CGG>AGG	p.R836R	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	836	Cytoplasmic (Potential).|C2 3.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GTACCAAGCCCGGGGCCTCAT	0.507			NA											22	90					2.79863e-10	3.93347e-10	0.004656	1	0
OC90	729330	broad.mit.edu	37	8	133053357	133053357	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:133053357C>A	uc003ytg.2	-	4	343	c.343G>T	c.(343-345)GAC>TAC	p.D115Y	OC90_uc011lix.1_Missense_Mutation_p.D131Y	NM_001080399	NP_001073868	Q02509	OC90_HUMAN	otoconin 90	131	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			ovary(2)|skin(1)	3	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			TGGAGACAGTCCATCTCAGCG	0.587			NA											27	114					4.31634e-10	6.04583e-10	0.002445	1	0
FAM135B	51059	broad.mit.edu	37	8	139180172	139180172	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:139180172G>C	uc003yuy.2	-	12	1395	c.1224C>G	c.(1222-1224)ATC>ATG	p.I408M	FAM135B_uc003yux.2_Missense_Mutation_p.I309M|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	408										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGTCCTCAAAGATCACCGGCA	0.542			NA								HNSCC(54;0.14)			25	152					0	0	0.003954	0	0
FAM135B	51059	broad.mit.edu	37	8	139209829	139209829	+	Silent	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:139209829A>T	uc003yuy.2	-	8	924	c.753T>A	c.(751-753)GCT>GCA	p.A251A	FAM135B_uc003yux.2_Silent_p.A152A|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	251										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GACCCCGGTAAGCGTGGAGGA	0.597			NA								HNSCC(54;0.14)			7	65					0	0	0.001984	0	0
TOP1MT	116447	broad.mit.edu	37	8	144407573	144407573	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:144407573T>G	uc003yxz.2	-	5	633	c.614A>C	c.(613-615)AAG>ACG	p.K205T	TOP1MT_uc011lkd.1_Missense_Mutation_p.K107T|TOP1MT_uc011lke.1_Missense_Mutation_p.K107T|TOP1MT_uc010mfb.2_Missense_Mutation_p.K107T|TOP1MT_uc011lkf.1_5'UTR|TOP1MT_uc010mfd.1_5'UTR	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	205					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	CATCCCCATCTTGGGATGGTC	0.577			NA											6	72					0	0	0.001984	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620288	144620288	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:144620288C>A	uc003yyd.2	-	2	1278	c.1249G>T	c.(1249-1251)GGG>TGG	p.G417W		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	417					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			GGTCTGTCCCCCGACGGGGAC	0.632			NA											6	70					0.00116845	0.00128122	0.001168	1	0
ZC3H3	23144	broad.mit.edu	37	8	144621362	144621362	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:144621362G>C	uc003yyd.2	-	2	204	c.175C>G	c.(175-177)CGG>GGG	p.R59G		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	59					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TAGCCCCTCCGGCTTGGACGA	0.652			NA											40	76					0	0	0.002522	0	0
GRINA	2907	broad.mit.edu	37	8	145065687	145065687	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr8:145065687A>T	uc003zan.1	+	2	462	c.296A>T	c.(295-297)TAC>TTC	p.Y99F	GRINA_uc003zao.1_Missense_Mutation_p.Y99F|GRINA_uc003zap.1_Missense_Mutation_p.Y99F	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	99	Pro-rich.					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CAAGGGGGCTACCCCCAGGGG	0.667			NA											4	10					0	0	0.009096	0	0
KIAA1432	57589	broad.mit.edu	37	9	5772720	5772720	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:5772720A>C	uc003zji.2	+	23	3629	c.3536A>C	c.(3535-3537)CAT>CCT	p.H1179P	KIAA1432_uc003zjl.3_Missense_Mutation_p.H1142P|ERMP1_uc011lme.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	1258						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		AAAGGGCCTCATAAATCCCAG	0.458			NA											5	18					0	0	0.001168	0	0
PTPRD	5789	broad.mit.edu	37	9	8449818	8449818	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:8449818A>T	uc003zkk.2	-	33	4606	c.3895T>A	c.(3895-3897)TCT>ACT	p.S1299T	PTPRD_uc003zkp.2_Missense_Mutation_p.S893T|PTPRD_uc003zkq.2_Missense_Mutation_p.S892T|PTPRD_uc003zkr.2_Missense_Mutation_p.S883T|PTPRD_uc003zks.2_Missense_Mutation_p.S878T|PTPRD_uc003zkl.2_Missense_Mutation_p.S1290T|PTPRD_uc003zkm.2_Missense_Mutation_p.S1286T|PTPRD_uc003zkn.2_Missense_Mutation_p.S888T|PTPRD_uc003zko.2_Missense_Mutation_p.S889T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1299	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTTTTTCTAGAGTCGGACTCT	0.423			NA								TSP Lung(15;0.13)			22	145					0	0	0.001882	0	0
TAF1L	138474	broad.mit.edu	37	9	32635336	32635336	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:32635336G>T	uc003zrg.1	-	1	332	c.242C>A	c.(241-243)ACG>AAG	p.T81K	uc003zrh.1_Intron	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	81					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTCATTTGCCGTGAGTTCAGT	0.522			NA											20	93					3.7963e-18	5.99494e-18	0.00333	1	0
PIP5K1B	8395	broad.mit.edu	37	9	71509280	71509280	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:71509280T>C	uc004agu.2	+	8	802	c.497T>C	c.(496-498)CTT>CCT	p.L166P	PIP5K1B_uc011lrq.1_Missense_Mutation_p.L166P|PIP5K1B_uc004agv.2_RNA	NM_003558	NP_003549	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type	166	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			stomach(1)	1				Lung(182;0.133)		CCAAGGACTCTTTTGCCAAAA	0.338			NA											18	100					0	0	0.007413	0	0
TRPM6	140803	broad.mit.edu	37	9	77436681	77436681	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:77436681T>G	uc004ajl.1	-	8	1152	c.914A>C	c.(913-915)GAG>GCG	p.E305A	TRPM6_uc004ajk.1_Missense_Mutation_p.E300A|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.E305A|TRPM6_uc010mpd.1_Missense_Mutation_p.E305A|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	305	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						CTTGACAGTCTCCCACACTGA	0.587			NA											4	39					0	0	0.009096	0	0
VPS13A	23230	broad.mit.edu	37	9	79890421	79890422	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:79890421_79890422GG>CT	uc004akr.2	+	25	2780_2781	c.2520_2521GG>CT	c.(2518-2523)GAGGAG>GACTAG	p.840_841EE>D*	VPS13A_uc004akp.3_Nonsense_Mutation_p.840_841EE>D*|VPS13A_uc004akq.3_Nonsense_Mutation_p.840_841EE>D*|VPS13A_uc004aks.2_Nonsense_Mutation_p.840_841EE>D*	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	840_841					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TAGATTCAGAGGAGGAATTTTT	0.312			NA											10	88					0	0	0.004672	0	0
VPS13A	23230	broad.mit.edu	37	9	79908412	79908412	+	Silent	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:79908412A>G	uc004akr.2	+	32	3755	c.3495A>G	c.(3493-3495)CTA>CTG	p.L1165L	VPS13A_uc004akp.3_Silent_p.L1165L|VPS13A_uc004akq.3_Silent_p.L1165L|VPS13A_uc004aks.2_Silent_p.L1126L|VPS13A_uc010mpo.1_5'UTR	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	1165					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						CGAAATTTCTATATTCTATAT	0.274			NA											19	49					0	0	0.007413	0	0
FLJ46321	389763	broad.mit.edu	37	9	84606402	84606402	+	Silent	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:84606402T>C	uc004amn.2	+	4	1064	c.1017T>C	c.(1015-1017)TCT>TCC	p.S339S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	339						integral to membrane					0						CATCCACCTCTGCCCCAACAA	0.468			NA											19	107					0	0	0.006122	0	0
C9orf3	84909	broad.mit.edu	37	9	97823056	97823056	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:97823056C>A	uc004ava.2	+	13	2331	c.2196C>A	c.(2194-2196)CTC>CTA	p.L732L	C9orf3_uc004auy.2_Silent_p.L633L|C9orf3_uc004auz.1_Silent_p.L633L|C9orf3_uc004avc.2_Silent_p.L187L|C9orf3_uc011luj.1_Silent_p.L94L|C9orf3_uc011luk.1_Silent_p.L73L|C9orf3_uc004avd.2_Silent_p.L94L	NM_032823	NP_116212	Q8N6M6	AMPO_HUMAN	aminopeptidase O	732					leukotriene biosynthetic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(323;0.000275)		TGCAAAGCCTCCAGAGGACAT	0.517			NA											9	36					0.000274275	0.000307338	0.004482	1	0
ASTN2	23245	broad.mit.edu	37	9	119976834	119976834	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:119976834A>T	uc004bjs.1	-	3	919	c.818T>A	c.(817-819)CTG>CAG	p.L273Q	ASTN2_uc004bjr.1_Missense_Mutation_p.L273Q|ASTN2_uc004bjt.1_Missense_Mutation_p.L273Q	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	273	Cytoplasmic (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						GTGGGTTTGCAGCCGGGATGA	0.602			NA											6	38					0	0	0.001168	0	0
ENG	2022	broad.mit.edu	37	9	130586661	130586661	+	Silent	SNP	C	C	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:130586661C>G	uc004bsj.3	-	8	1469	c.1056G>C	c.(1054-1056)CCG>CCC	p.P352P	ENG_uc011mam.1_Silent_p.P163P|ENG_uc004bsk.3_Silent_p.P352P	NM_001114753	NP_001108225	P17813	EGLN_HUMAN	endoglin isoform 1 precursor	352	Ser/Thr-rich.|Extracellular (Potential).				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding				0						TGAGCAGCTCCGGGCTACAAG	0.597			NA							Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				12	37					0	0	0.001368	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670205	131670205	+	Silent	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr9:131670205G>T	uc004bwl.3	+	3	1016	c.762G>T	c.(760-762)GTG>GTT	p.V254V	LRRC8A_uc010myp.2_Silent_p.V254V|LRRC8A_uc010myq.2_Silent_p.V254V	NM_019594	NP_062540	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member	254					pre-B cell differentiation	integral to membrane					0						GGACCCATGTGGAGGAGGGGG	0.557			NA											11	55					3.86212e-05	4.55218e-05	0.008291	1	0
ZBED1	9189	broad.mit.edu	37	X	2406876	2406877	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:2406876_2406877CC>AA	uc004cqg.2	-	2	2085_2086	c.1884_1885GG>TT	c.(1882-1887)GTGGTC>GTTTTC	p.V629F	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Missense_Mutation_p.V629F	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	629						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGCGCTGACCACGTTGGCGG	0.673			NA											34	96					0	0	0.004672	0	0
ZBED1	9189	broad.mit.edu	37	X	2407791	2407791	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:2407791G>A	uc004cqg.2	-	2	1171	c.970C>T	c.(970-972)CAG>TAG	p.Q324*	DHRSX_uc004cqf.3_Intron|ZBED1_uc004cqh.1_Nonsense_Mutation_p.Q324*	NM_004729	NP_004720	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	324						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				ACGGCAGACTGCTGGAAGTAC	0.632			NA											15	28					0	0	0.00245	0	0
ARSF	416	broad.mit.edu	37	X	3030325	3030325	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:3030325C>A	uc004cre.1	+	11	1722	c.1501C>A	c.(1501-1503)CAC>AAC	p.H501N	ARSF_uc004crf.1_Missense_Mutation_p.H501N	NM_004042	NP_004033	P54793	ARSF_HUMAN	arylsulfatase F precursor	501						extracellular region	arylsulfatase activity|metal ion binding			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTTACCTACCACAACCCCCC	0.532			NA											16	91					8.28177e-16	1.27821e-15	0.007413	1	0
SMS	6611	broad.mit.edu	37	X	22010739	22010739	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:22010739G>T	uc004dag.2	+	10	1071	c.970G>T	c.(970-972)GCA>TCA	p.A324S	SMS_uc010nfs.2_RNA|SMS_uc010nft.2_Intron	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	324					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	TCTGACAGAAGCACTGTCGCT	0.443			NA											7	54					2.74318e-10	3.86883e-10	0.006214	1	0
FAM47A	158724	broad.mit.edu	37	X	34149722	34149722	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:34149722G>C	uc004ddg.2	-	1	707	c.674C>G	c.(673-675)CCG>CGG	p.P225R		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	225	Pro-rich.							p.P225P(1)		ovary(4)|central_nervous_system(1)	5						AGGAGGCTCCGGGCGGAGACT	0.662			NA											7	41					0	0	0.001984	0	0
FAM47C	442444	broad.mit.edu	37	X	37028384	37028384	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:37028384C>T	uc004ddl.1	+	1	1915	c.1901C>T	c.(1900-1902)CCT>CTT	p.P634L		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	634										ovary(3)	3						CGCCCAGAGCCTCCCAAGACT	0.627			NA											10	94					0	0	0.001368	0	0
SYTL5	94122	broad.mit.edu	37	X	37984682	37984682	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:37984682T>C	uc004ddu.2	+	17	2507	c.1973T>C	c.(1972-1974)CTA>CCA	p.L658P	SYTL5_uc004ddv.2_Missense_Mutation_p.L658P|SYTL5_uc004ddx.2_Missense_Mutation_p.L680P	NM_001163335	NP_001156807	Q8TDW5	SYTL5_HUMAN	synaptotagmin-like 5 isoform 1	658	C2 2.				intracellular protein transport	membrane	metal ion binding|Rab GTPase binding			skin(1)	1						AATGTTTGCCTAGAACTTACT	0.438			NA											12	101					0	0	0.000978	0	0
TBX22	50945	broad.mit.edu	37	X	79286020	79286020	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:79286020G>T	uc010nmg.1	+	9	1107	c.973G>T	c.(973-975)GTG>TTG	p.V325L	TBX22_uc004edi.1_Missense_Mutation_p.V205L|TBX22_uc004edj.1_Missense_Mutation_p.V325L	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	325					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CTCATCTCCAGTGACCTCTAG	0.433			NA											16	67					2.32078e-09	3.15349e-09	0.003163	1	0
COL4A5	1287	broad.mit.edu	37	X	107858176	107858177	+	Missense_Mutation	DNP	GG	GG	TT	rs104886182		TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:107858176_107858177GG>TT	uc004enz.1	+	30	2633_2634	c.2431_2432GG>TT	c.(2431-2433)GGA>TTA	p.G811L	COL4A5_uc011mso.1_Missense_Mutation_p.G811L|COL4A5_uc004eob.1_Missense_Mutation_p.G419L	NM_033380	NP_203699	P29400	CO4A5_HUMAN	type IV collagen alpha 5 isoform 2 precursor	811	Triple-helical region.		G -> V (in APSX; juvenile type).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			ovary(3)|central_nervous_system(1)	4						TGGACCAATGGGACCTCCTGGG	0.46			NA							Alport_syndrome_with_Diffuse_Leiomyomatosis				10	30					0	0	0.004672	0	0
DOCK11	139818	broad.mit.edu	37	X	117758564	117758564	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:117758564A>G	uc004eqp.2	+	32	3597	c.3534A>G	c.(3532-3534)ATA>ATG	p.I1178M	DOCK11_uc004eqq.2_Missense_Mutation_p.I957M	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1178					blood coagulation	cytosol	GTP binding			ovary(3)	3						TGGAAAATATACAGCGATTAG	0.338			NA											83	186					0	0	0.00361	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128975781	128975781	+	Silent	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:128975781C>A	uc004euv.2	-	2	510	c.141G>T	c.(139-141)GGG>GGT	p.G47G	ZDHHC9_uc004euw.2_Silent_p.G47G|ZDHHC9_uc004eux.1_Silent_p.G47G|ZDHHC9_uc004euy.1_Intron	NM_001008222	NP_001008223	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC domain containing 9	47	Helical; (Potential).					endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)	1						GTGTACATGTCCCCAGGATGA	0.517			NA											33	82					6.02846e-25	1.00229e-24	0.003271	1	0
MST4	51765	broad.mit.edu	37	X	131206387	131206387	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:131206387G>T	uc004ewk.1	+	9	1325	c.1024G>T	c.(1024-1026)GCA>TCA	p.A342S	MST4_uc004ewl.1_Missense_Mutation_p.A265S|MST4_uc011mux.1_Missense_Mutation_p.A364S|MST4_uc010nrj.1_Missense_Mutation_p.A342S|MST4_uc004ewm.1_Missense_Mutation_p.A280S	NM_016542	NP_057626	Q9P289	MST4_HUMAN	serine/threonine protein kinase MST4 isoform 1	342					cellular component disassembly involved in apoptosis|regulation of apoptosis	cytosol|Golgi membrane	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(3)|stomach(2)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(192;0.000127)					ACAGAATGGGGCAGTATGTAT	0.388			NA											17	29					3.99206e-14	6.04723e-14	0.007413	1	0
MAGEC1	9947	broad.mit.edu	37	X	140995890	140995890	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:140995890C>A	uc004fbt.2	+	4	2986	c.2700C>A	c.(2698-2700)AGC>AGA	p.S900R	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	900							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					TGATAGAGAGCGAGCCCTTGT	0.473			NA								HNSCC(15;0.026)			87	171					1.52795e-29	2.55073e-29	0.00361	1	0
AFF2	2334	broad.mit.edu	37	X	148038041	148038041	+	Silent	SNP	A	A	C			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chrX:148038041A>C	uc004fcp.2	+	11	2945	c.2466A>C	c.(2464-2466)GCA>GCC	p.A822A	AFF2_uc004fcq.2_Silent_p.A812A|AFF2_uc004fcr.2_Silent_p.A783A|AFF2_uc011mxb.1_Silent_p.A787A|AFF2_uc004fcs.2_Silent_p.A789A|AFF2_uc011mxc.1_Silent_p.A463A	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	822					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TCCATGCAGCACCTGCCAAGC	0.532			NA											7	32					0	0	0.000978	0	0
PKLR	5313	broad.mit.edu	37	1	155261655	155261655	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr1:155261655delG	uc001fkb.3	-	10	1549	c.1510delC	c.(1510-1512)CGCfs	p.R504fs	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Frame_Shift_Del_p.R473fs	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	504			R -> L (in PKRD; unstability of the protein).		endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	TGGACCTGGCGGGCAGCCTGG	0.602			NA											18	92	---	---	---	---	NA	NA	NA	NA	NA
C10orf82	143379	broad.mit.edu	37	10	118424338	118424338	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr10:118424338delT	uc001lcr.2	-	4	450	c.395delA	c.(394-396)AACfs	p.N132fs	C10orf82_uc001lcs.1_3'UTR	NM_144661	NP_653262	Q8WW14	CJ082_HUMAN	hypothetical protein LOC143379	132											0				all cancers(201;0.0143)		CTTGTAGCAGTTTTTGGCCAT	0.567			NA											8	204	---	---	---	---	NA	NA	NA	NA	NA
MKRN3	7681	broad.mit.edu	37	15	23811300	23811300	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr15:23811300delG	uc001ywh.3	+	1	847	c.371delG	c.(370-372)CGGfs	p.R124fs	MKRN3_uc001ywi.2_Intron|MKRN3_uc010ayi.1_Frame_Shift_Del_p.R124fs	NM_005664	NP_005655	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	124						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			lung(6)|large_intestine(2)|ovary(2)	10		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		CTTTCTGGTCGGAAGATGGCC	0.602			NA											11	65	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29562721	29562721	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:29562721delG	uc002hgg.2	+	28	4134	c.3801delG	c.(3799-3801)TTGfs	p.L1267fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L1267fs|NF1_uc010csn.1_Frame_Shift_Del_p.L1127fs|NF1_uc002hgi.1_Frame_Shift_Del_p.L300fs	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1267	Ras-GAP.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(2)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAGTAGAATTGGCAGACTCCA	0.413			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			88	321	---	---	---	---	NA	NA	NA	NA	NA
NF1	4763	broad.mit.edu	37	17	29679430	29679430	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr17:29679430delT	uc002hgg.2	+	51	7946	c.7613delT	c.(7612-7614)CTTfs	p.L2538fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L2517fs|NF1_uc010cso.2_Frame_Shift_Del_p.L726fs|NF1_uc010wbt.1_Intron|NF1_uc010wbu.1_RNA	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	2538					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity			soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		AAGAAGTTGCTTGGTTAGTTT	0.363			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			10	26	---	---	---	---	NA	NA	NA	NA	NA
GALNT14	79623	broad.mit.edu	37	2	31178519	31178519	+	Frame_Shift_Del	DEL	C	C	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr2:31178519delC	uc002rnr.2	-	6	1238	c.619delG	c.(619-621)GACfs	p.D207fs	GALNT14_uc002rnq.2_Frame_Shift_Del_p.D187fs|GALNT14_uc002rns.2_Frame_Shift_Del_p.D212fs|GALNT14_uc010ymr.1_Frame_Shift_Del_p.D172fs|GALNT14_uc010ezo.1_Frame_Shift_Del_p.D174fs|GALNT14_uc010ezp.1_Frame_Shift_Del_p.D178fs	NM_024572	NP_078848	Q96FL9	GLT14_HUMAN	N-acetylgalactosaminyltransferase 14	207	Lumenal (Potential).|Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(2)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TGGAGCCAGTCCCTGTTCACC	0.632			NA											18	43	---	---	---	---	NA	NA	NA	NA	NA
ARHGEF38	54848	broad.mit.edu	37	4	106534548	106534549	+	Frame_Shift_Ins	INS	-	-	TATC			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr4:106534548_106534549insTATC	uc003hxu.2	+	3	538_539	c.392_393insTATC	c.(391-393)AGGfs	p.R131fs		NM_017700	NP_060170	Q9NXL2	ARH38_HUMAN	hypothetical protein LOC54848	131	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|breast(1)	3						CAGACTGATAGGCTGGATGTGG	0.441			NA											15	221	---	---	---	---	NA	NA	NA	NA	NA
ZFR	51663	broad.mit.edu	37	5	32419951	32419953	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	GGT	GGT	-	-	GGT	GGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr5:32419951_32419953delGGT	uc003jhr.1	-	3	473_475	c.393_395delACC	c.(391-396)CCACCC>CCC	p.131_132PP>P	ZFR_uc010iun.1_In_Frame_Del_p.131_132PP>P	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	131_132	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		AGTAGCTGGGGGTGGTGGTGGTG	0.483			NA											7	498	---	---	---	---	NA	NA	NA	NA	NA
PTPRZ1	5803	broad.mit.edu	37	7	121651908	121651909	+	Frame_Shift_Ins	INS	-	-	T			TCGA-50-6593-01A-11D-1753-08	TCGA-50-6593-11A-01D-1753-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	10e03053-f6e3-42b7-8638-ce58c6e7dfaa	acd8a6fc-5145-499f-9d88-9bd6082a0d9b	g.chr7:121651908_121651909insT	uc003vjy.2	+	12	3203_3204	c.2808_2809insT	c.(2806-2811)TCCCAAfs	p.S936fs	PTPRZ1_uc003vjz.2_Intron|PTPRZ1_uc011knt.1_Intron	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	936_937	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						ATGAGGGCTCCCAACACATCTT	0.455			NA											22	106	---	---	---	---	NA	NA	NA	NA	NA