Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CAMTA1	23261	broad.mit.edu	37	1	7805023	7805023	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:7805023G>C	uc001aoi.2	+	17	4518	c.4311G>C	c.(4309-4311)ATG>ATC	p.M1437I	CAMTA1_uc010nzv.1_Missense_Mutation_p.M524I|CAMTA1_uc001aok.3_Missense_Mutation_p.M480I|CAMTA1_uc001aoj.2_Missense_Mutation_p.M393I|CAMTA1_uc009vmf.2_Missense_Mutation_p.M41I	NM_015215	NP_056030	Q9Y6Y1	CMTA1_HUMAN	calmodulin-binding transcription activator 1	1437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			ovary(5)|central_nervous_system(2)|breast(1)|pancreas(1)	9	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		GCAGTACAATGAGCTGGCTGG	0.517			NA											4	65					0	0	0.00024832	0	0
PRAMEF12	390999	broad.mit.edu	37	1	12836075	12836075	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:12836075T>A	uc001aui.2	+	2	704	c.677T>A	c.(676-678)CTG>CAG	p.L226Q		NM_001080830	NP_001074299	O95522	PRA12_HUMAN	PRAME family member 12	226										ovary(3)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCCTTACCTGGGCCAGATG	0.522			NA											28	85					0	0	0.000878237	0	0
CELA2A	63036	broad.mit.edu	37	1	15783627	15783627	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:15783627G>T	uc001awk.2	+	2	113	c.87G>T	c.(85-87)GTG>GTT	p.V29V		NM_033440	NP_254275	P08217	CEL2A_HUMAN	elastase 2A preproprotein	29	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						TGACTAGGGTGGTTGGCGGTG	0.567			NA											8	30					1.58986e-06	5.52161e-06	0.000673444	1	0
IL22RA1	58985	broad.mit.edu	37	1	24454646	24454646	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:24454646C>A	uc001biq.1	-	5	694	c.655G>T	c.(655-657)GTG>TTG	p.V219L	IL22RA1_uc010oeg.1_Missense_Mutation_p.V111L|IL22RA1_uc009vrb.1_Missense_Mutation_p.V83L|IL22RA1_uc010oeh.1_Missense_Mutation_p.V219L	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	219	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGTGTCTTCACTCGGCACATG	0.547			NA											4	23					0.00024832	0.000757292	0.00024832	1	0
HMGB4	127540	broad.mit.edu	37	1	34330269	34330269	+	Silent	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:34330269C>G	uc001bxp.2	+	2	2220	c.477C>G	c.(475-477)CTC>CTG	p.L159L	CSMD2_uc001bxm.1_Intron|CSMD2_uc001bxn.1_Intron|HMGB4_uc001bxq.2_Silent_p.L85L	NM_145205	NP_660206	Q8WW32	HMGB4_HUMAN	HMG2 like isoform 1	159						nucleus	DNA binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AACTTGAACTCTACCGTAAAC	0.488			NA											5	32					0	0	0.00116845	0	0
ZMYM4	9202	broad.mit.edu	37	1	35862216	35862216	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:35862216T>A	uc001byt.2	+	19	3055	c.2975T>A	c.(2974-2976)ATA>AAA	p.I992K	ZMYM4_uc009vuu.2_Missense_Mutation_p.I960K|ZMYM4_uc001byu.2_Missense_Mutation_p.I668K|ZMYM4_uc009vuv.2_Missense_Mutation_p.I731K	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	992					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TTTGTTCCCATACCTCTTCAC	0.393			NA											18	73					0	0	0.00121646	0	0
KIAA0467	23334	broad.mit.edu	37	1	43896264	43896264	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:43896264A>G	uc001cjk.1	+	17	2343	c.1881A>G	c.(1879-1881)CTA>CTG	p.L627L		NM_015284	NP_056099	Q5T011	SZT2_HUMAN	hypothetical protein LOC23334	1526						peroxisome					0	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CTGCTGGGCTAGACTCTGCCT	0.567			NA											10	51					0	0	0.00185496	0	0
FAF1	11124	broad.mit.edu	37	1	50941222	50941222	+	Missense_Mutation	SNP	T	T	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:50941222T>G	uc009vyx.1	-	19	1846	c.1783A>C	c.(1783-1785)AAG>CAG	p.K595Q	FAF1_uc009vyw.1_RNA|FAF1_uc001cse.1_Missense_Mutation_p.K595Q|FAF1_uc010onc.1_Missense_Mutation_p.K353Q	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1	595	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		ATCTGGAGCTTGTTGCTGGCC	0.512			NA											7	49					0	0	0.00198382	0	0
EPS15	2060	broad.mit.edu	37	1	51869091	51869091	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:51869091C>A	uc001csq.1	-	17	1883	c.1791G>T	c.(1789-1791)GAG>GAT	p.E597D	EPS15_uc009vyz.1_Missense_Mutation_p.E463D|EPS15_uc001csp.3_Missense_Mutation_p.E283D	NM_001981	NP_001972	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway	597					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding			lung(1)|kidney(1)	2						CATTTTTTACCTCTTTTGAAT	0.204			NA	T	MLL	ALL								7	52					2.7689e-08	1.06575e-07	0.00198382	1	0
DMRTB1	63948	broad.mit.edu	37	1	53930460	53930460	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:53930460C>A	uc001cvq.1	+	3	956	c.901C>A	c.(901-903)CCA>ACA	p.P301T		NM_033067	NP_149056	Q96MA1	DMRTB_HUMAN	DMRT-like family B with proline-rich C-terminal,	301	Pro-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						GCCACCGCCACCACCACCTCC	0.557			NA											7	71					5.18039e-06	1.7629e-05	0.00307968	1	0
SGIP1	84251	broad.mit.edu	37	1	67147941	67147941	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:67147941G>C	uc001dcr.2	+	15	1421	c.1204G>C	c.(1204-1206)GAT>CAT	p.D402H	SGIP1_uc010opd.1_Intron|SGIP1_uc001dcs.2_Intron|SGIP1_uc001dct.2_Intron|SGIP1_uc009wat.2_Missense_Mutation_p.D169H	NM_032291	NP_115667	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting	402	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			ovary(3)	3						ATCTCCTAAAGATTTTGGGTT	0.512			NA											16	84					0	0	0.00400662	0	0
GBP4	115361	broad.mit.edu	37	1	89655932	89655932	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:89655932G>A	uc001dnb.2	-	7	1102	c.986C>T	c.(985-987)GCA>GTA	p.A329V		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	329						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		TGCTGTCACTGCATTCTCCAG	0.537			NA											15	44					0	0	0.00074312	0	0
HFM1	164045	broad.mit.edu	37	1	91739299	91739299	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:91739299T>C	uc001doa.3	-	34	3842	c.3742A>G	c.(3742-3744)AGA>GGA	p.R1248G	HFM1_uc009wdb.2_RNA|HFM1_uc010osu.1_Missense_Mutation_p.R927G|HFM1_uc001dob.3_Missense_Mutation_p.R436G|HFM1_uc010osv.1_Missense_Mutation_p.R932G	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1248							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		GGTTCTTGTCTAACTTTTCCA	0.318			NA											16	60					0	0	0.000958276	0	0
OLFM3	118427	broad.mit.edu	37	1	102269968	102269969	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:102269968_102269969GG>TT	uc001duf.2	-	6	1333_1334	c.1262_1263CC>AA	c.(1261-1263)TCC>TAA	p.S421*	OLFM3_uc001dug.2_Nonsense_Mutation_p.S401*|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Nonsense_Mutation_p.S326*|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	421	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGGTTTTGGTGGAATAGGAATA	0.446			NA											21	164					0	0	6.4e-05	0	0
HIST2H3D	653604	broad.mit.edu	37	1	149784921	149784921	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:149784921C>T	uc010pbl.1	-	1	316	c.316G>A	c.(316-318)GAA>AAA	p.E106K	HIST2H2BF_uc010pbj.1_5'Flank|HIST2H2BF_uc010pbk.1_5'Flank|HIST2H2BF_uc001esr.2_5'Flank	NM_001123375	NP_001116847	Q71DI3	H32_HUMAN	histone cluster 2, H3d	106					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding|protein binding				0						TTCGTGTCTTCGAACAGCCCC	0.652			NA											6	32					0	0	0.00116845	0	0
HORMAD1	84072	broad.mit.edu	37	1	150681431	150681431	+	Missense_Mutation	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:150681431A>C	uc001evk.1	-	8	440	c.334T>G	c.(334-336)TCA>GCA	p.S112A	HORMAD1_uc001evl.1_Missense_Mutation_p.S105A|HORMAD1_uc001evm.1_Missense_Mutation_p.S32A	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	112	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TAACATTCTGAAATTGTCTTA	0.303			NA											5	45					0	0	0.00116845	0	0
FLG	2312	broad.mit.edu	37	1	152280118	152280119	+	Missense_Mutation	DNP	AG	AG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152280118_152280119AG>TT	uc001ezu.1	-	3	7279_7280	c.7243_7244CT>AA	c.(7243-7245)CTC>AAC	p.L2415N		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2415	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACCTGGTAGAGGAAAGACCCT	0.614			NA							Ichthyosis				27	143					0	0	6.4e-05	0	0
FLG2	388698	broad.mit.edu	37	1	152324228	152324228	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152324228G>T	uc001ezw.3	-	3	6107	c.6034C>A	c.(6034-6036)CAT>AAT	p.H2012N	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2012	Filaggrin 9.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTGTCCATGACCAGAGTGG	0.527			NA											91	235					1.42479e-40	7.31895e-40	0.00361006	1	0
FLG2	388698	broad.mit.edu	37	1	152325056	152325056	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152325056C>A	uc001ezw.3	-	3	5279	c.5206G>T	c.(5206-5208)GGG>TGG	p.G1736W	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1736							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCTGAGTACCCTTCACTGTCA	0.488			NA											70	219					8.29215e-51	4.29222e-50	0.00361006	1	0
LCE3A	353142	broad.mit.edu	37	1	152595328	152595328	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:152595328A>G	uc010pdt.1	-	1	252	c.252T>C	c.(250-252)AGT>AGC	p.S84S		NM_178431	NP_848518	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	84					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCCGCAGAACTGTGGCCAC	0.547			NA											7	54					0	0	0.00198382	0	0
BCAN	63827	broad.mit.edu	37	1	156628521	156628521	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:156628521G>A	uc001fpp.2	+	13	2960	c.2624G>A	c.(2623-2625)AGA>AAA	p.R875K		NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	875					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GTGCCCAGAAGACCTGTGAGT	0.468			NA											11	38					0	0	0.000978159	0	0
CD1A	909	broad.mit.edu	37	1	158225793	158225793	+	Splice_Site	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:158225793G>C	uc001frt.2	+	3	859	c.326_splice	c.e3-1	p.Y109_splice		NM_001763	NP_001754	P06126	CD1A_HUMAN	CD1A antigen precursor						antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	CATAACCCCAGATCCTTTTGA	0.423			NA											18	75					0	0	0.00121646	0	0
MNDA	4332	broad.mit.edu	37	1	158813834	158813834	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:158813834C>A	uc001fsz.1	+	4	692	c.492C>A	c.(490-492)GCC>GCA	p.A164A		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	164					B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					CCTCAGGAGCCAGCACATCTG	0.488			NA											30	79					8.88839e-20	4.25823e-19	0.00209593	1	0
CACNA1E	777	broad.mit.edu	37	1	181452918	181452918	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:181452918G>T	uc001gow.2	+	1	203	c.38G>T	c.(37-39)GGG>GTG	p.G13V		NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	13	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GCCAGGCCAGGGTCCGGCGAT	0.652			NA											11	22					1.36491e-13	6.20874e-13	0.00185496	1	0
HMCN1	83872	broad.mit.edu	37	1	186008104	186008104	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:186008104G>T	uc001grq.1	+	38	6224	c.5995G>T	c.(5995-5997)GCT>TCT	p.A1999S		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1999	Ig-like C2-type 17.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						CTCAGCTGGAGCTACAGAGTT	0.408			NA											18	81					2.35188e-11	1.0087e-10	0.00074312	1	0
ZBTB41	360023	broad.mit.edu	37	1	197150178	197150178	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:197150178C>G	uc001gtx.1	-	5	1685	c.1616G>C	c.(1615-1617)TGT>TCT	p.C539S	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	539	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						ACCATGAGTACATTCTATATG	0.358			NA											14	60					0	0	0.00185496	0	0
KDM5B	10765	broad.mit.edu	37	1	202711841	202711841	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:202711841C>G	uc001gyf.2	-	17	2532	c.2416G>C	c.(2416-2418)GAT>CAT	p.D806H	KDM5B_uc009xag.2_Missense_Mutation_p.D842H|KDM5B_uc001gyg.1_Missense_Mutation_p.D648H	NM_006618	NP_006609	Q9UGL1	KDM5B_HUMAN	jumonji, AT rich interactive domain 1B	806					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(2)|breast(2)|urinary_tract(1)	5						TTCTCTGCATCCTGTGTGACT	0.458			NA											25	89					0	0	0.00395357	0	0
CR2	1380	broad.mit.edu	37	1	207646412	207646412	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:207646412C>A	uc001hfw.2	+	10	1960	c.1866C>A	c.(1864-1866)TAC>TAA	p.Y622*	CR2_uc001hfv.2_Nonsense_Mutation_p.Y622*|CR2_uc009xch.2_Nonsense_Mutation_p.Y622*|CR2_uc009xci.1_Nonsense_Mutation_p.Y107*	NM_001877	NP_001868	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus)	622	Sushi 10.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			upper_aerodigestive_tract(3)|skin(3)|urinary_tract(1)|ovary(1)	8						CATATTTCTACAATGACACTG	0.438			NA											14	71					4.36969e-10	1.77815e-09	0.00185496	1	0
MARK1	4139	broad.mit.edu	37	1	220825454	220825454	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:220825454G>C	uc001hmn.3	+	15	2295	c.1698G>C	c.(1696-1698)CTG>CTC	p.L566L	MARK1_uc009xdw.2_Silent_p.L566L|MARK1_uc010pun.1_Silent_p.L566L|MARK1_uc001hmm.3_Silent_p.L544L	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	566					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		AAGTCACACTGCCAACCATTA	0.473			NA											13	78					0	0	0.00244969	0	0
HHIPL2	79802	broad.mit.edu	37	1	222717364	222717364	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:222717364C>A	uc001hnh.1	-	2	547	c.489G>T	c.(487-489)AGG>AGT	p.R163S		NM_024746	NP_079022	Q6UWX4	HIPL2_HUMAN	HHIP-like 2 precursor	163					carbohydrate metabolic process	extracellular region	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding			ovary(1)	1				GBM - Glioblastoma multiforme(131;0.0185)		GGGTACCGTCCCTTCCATGAG	0.567			NA											14	46					0.000151284	0.000470934	0.00185496	1	0
AGT	183	broad.mit.edu	37	1	230841707	230841707	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:230841707G>T	uc001hty.3	-	3	1604	c.1096C>A	c.(1096-1098)CTC>ATC	p.L366I	AGT_uc009xfe.2_Missense_Mutation_p.L366I|AGT_uc009xff.2_Missense_Mutation_p.L338I	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	366					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	ATCCAGTTGAGGGAGTTTTGC	0.607			NA											20	75					4.35082e-09	1.71369e-08	0.00152264	1	0
AGT	183	broad.mit.edu	37	1	230846414	230846414	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:230846414C>A	uc001hty.3	-	2	691	c.183G>T	c.(181-183)AAG>AAT	p.K61N	AGT_uc009xfe.2_Missense_Mutation_p.K61N|AGT_uc009xff.2_Intron	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	61					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	GGTCTTTGGGCTTCCCGGCAT	0.572			NA											6	33					8.12818e-05	0.000254784	0.00198382	1	0
C1orf101	257044	broad.mit.edu	37	1	244747191	244747191	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:244747191G>T	uc001iam.2	+	13	2094	c.2035G>T	c.(2035-2037)GTT>TTT	p.V679F	C1orf101_uc001iak.1_Missense_Mutation_p.V233F|C1orf101_uc001ial.2_Missense_Mutation_p.V679F|C1orf101_uc010pym.1_Missense_Mutation_p.V528F|C1orf101_uc010pyn.1_Missense_Mutation_p.V612F	NM_001130957	NP_001124429	Q5SY80	CA101_HUMAN	hypothetical protein LOC257044 isoform 1	679	Extracellular (Potential).					integral to membrane				ovary(1)|breast(1)	2	all_cancers(71;2.99e-05)|all_epithelial(71;0.00015)|all_neural(11;0.0269)|Breast(184;0.0654)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0874)|Lung NSC(105;0.121)		all cancers(7;1.22e-05)|OV - Ovarian serous cystadenocarcinoma(106;0.001)|GBM - Glioblastoma multiforme(7;0.0154)			TCTTGTGCTGGTTCAGTTTCG	0.423			NA											14	26					0.000219431	0.000672226	0.00244969	1	0
OR2B11	127623	broad.mit.edu	37	1	247614745	247614745	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:247614745G>C	uc010pyx.1	-	1	540	c.540C>G	c.(538-540)AAC>AAG	p.N180K		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	180	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CACAGAAAAAGTTGTTCAGCA	0.592			NA											5	19					0	0	0.00116845	0	0
OR2L2	26246	broad.mit.edu	37	1	248201833	248201833	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248201833C>G	uc001idw.2	+	1	360	c.264C>G	c.(262-264)AAC>AAG	p.N88K	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	88	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			tgtatggaaacaagtctatct	0.303			NA											46	220					0	0	0.0025221	0	0
OR2L2	26246	broad.mit.edu	37	1	248202089	248202089	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248202089A>G	uc001idw.2	+	1	616	c.520A>G	c.(520-522)AAT>GAT	p.N174D	OR2L13_uc001ids.2_Intron	NM_001004686	NP_001004686	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAGAGCCATCAATCATTTTTT	0.428			NA											72	201					0	0	0.00361006	0	0
OR2L3	391192	broad.mit.edu	37	1	248224498	248224498	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248224498C>G	uc001idx.1	+	1	515	c.515C>G	c.(514-516)GCC>GGC	p.A172G	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	172	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAATCCAGGGCCATCAATCAT	0.468			NA											31	131					0	0	0.00178596	0	0
OR2L3	391192	broad.mit.edu	37	1	248224827	248224827	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248224827C>A	uc001idx.1	+	1	844	c.844C>A	c.(844-846)CCA>ACA	p.P282T	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CACCCTCACTCCAATGCTCAA	0.488			NA											21	63					5.45024e-15	2.52167e-14	0.00332997	1	0
OR14C36	127066	broad.mit.edu	37	1	248512663	248512663	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248512663T>C	uc010pzl.1	+	1	587	c.587T>C	c.(586-588)ATG>ACG	p.M196T		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AATGAGGTCATGATTGTTGTC	0.493			NA											13	71					0	0	0.00185496	0	0
OR14C36	127066	broad.mit.edu	37	1	248512671	248512671	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248512671G>T	uc010pzl.1	+	1	595	c.595G>T	c.(595-597)GTC>TTC	p.V199F		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	199	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						CATGATTGTTGTCTCTGCTCT	0.488			NA											11	71					5.50884e-06	1.84676e-05	0.00136819	1	0
OR2T6	254879	broad.mit.edu	37	1	248551233	248551233	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248551233G>T	uc001iei.1	+	1	324	c.324G>T	c.(322-324)ATG>ATT	p.M108I		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGGCTTTATGGGGGCTGAAT	0.562			NA											12	67					6.40141e-05	0.00020349	0.000978159	1	0
OR2T1	26696	broad.mit.edu	37	1	248570293	248570294	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248570293_248570294CC>AA	uc010pzm.1	+	1	998_999	c.998_999CC>AA	c.(997-999)CCC>CAA	p.P333Q		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	333	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATTCTCACACCCATGCTGAACC	0.525			NA											27	122					0	0	6.4e-05	0	0
OR2T3	343173	broad.mit.edu	37	1	248637474	248637474	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248637474C>A	uc001iel.1	+	1	823	c.823C>A	c.(823-825)CAG>AAG	p.Q275K		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	275	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CACAGCTGAGCAGGACATGAT	0.542			NA											36	266					1.59932e-28	8.03229e-28	0.00170553	1	0
OR2T5	401993	broad.mit.edu	37	1	248652006	248652006	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:248652006C>A	uc001iem.1	+	1	117	c.117C>A	c.(115-117)TTC>TTA	p.F39L		NM_001004697	NP_001004697	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T,	39	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGTGGTTTTCCTGAAGGCGT	0.478			NA											16	108					2.19358e-23	1.08554e-22	0.00111076	1	0
ANKRD16	54522	broad.mit.edu	37	10	5927686	5927686	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:5927686C>A	uc010qat.1	-	3	1121	c.578G>T	c.(577-579)AGG>ATG	p.R193M	ANKRD16_uc009xie.2_Missense_Mutation_p.R193M|ANKRD16_uc009xif.2_Missense_Mutation_p.R193M|ANKRD16_uc001iiq.2_Missense_Mutation_p.R193M	NM_019046	NP_061919	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16 isoform a	193	ANK 5.										0						ttgttcttacctcttaaGAAG	0.214			NA											7	30					5.18039e-06	1.7629e-05	0.00307968	1	0
FBXO18	84893	broad.mit.edu	37	10	5960359	5960359	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:5960359C>A	uc001iis.2	+	13	2113	c.2018C>A	c.(2017-2019)CCG>CAG	p.P673Q	FBXO18_uc001iir.2_Missense_Mutation_p.P599Q|FBXO18_uc009xig.2_Missense_Mutation_p.P599Q|FBXO18_uc001iit.2_Missense_Mutation_p.P724Q	NM_178150	NP_835363	Q8NFZ0	FBX18_HUMAN	F-box only protein, helicase, 18 isoform 2	673					DNA repair	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(2)|skin(1)	3						GTAGGGGACCCGCACCAGCAG	0.537			NA											7	98					0.00307968	0.00896691	0.00307968	1	0
FAM171A1	221061	broad.mit.edu	37	10	15255673	15255673	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:15255673C>A	uc001iob.2	-	8	1921	c.1914G>T	c.(1912-1914)CTG>CTT	p.L638L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	638	Cytoplasmic (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						CCTGGGAAGACAGGGGCTGGG	0.602			NA											16	22					0.000308642	0.000932831	0.00316338	1	0
ITGA8	8516	broad.mit.edu	37	10	15600165	15600165	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:15600165C>T	uc001ioc.1	-	26	2674	c.2674G>A	c.(2674-2676)GCC>ACC	p.A892T	ITGA8_uc010qcb.1_Missense_Mutation_p.A877T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	892	Extracellular (Potential).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						CGCAAAAAGGCGCTGAGCTCA	0.458			NA											12	40					0	0	0.00185496	0	0
YME1L1	10730	broad.mit.edu	37	10	27409370	27409370	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:27409370C>A	uc001iti.2	-	14	1758	c.1576G>T	c.(1576-1578)GAT>TAT	p.D526Y	YME1L1_uc001itj.2_Missense_Mutation_p.D469Y|YME1L1_uc010qdl.1_Missense_Mutation_p.D436Y|YME1L1_uc009xkv.2_Intron	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	526					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						TTACATTGATCAAACTTTATT	0.333			NA											11	40					9.70103e-10	3.92398e-09	0.000673444	1	0
LOC387646	387646	broad.mit.edu	37	10	27539200	27539200	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:27539200G>T	uc001its.2	-	1	2036	c.193C>A	c.(193-195)CAT>AAT	p.H65N		NR_003525				SubName: Full=cDNA FLJ44924 fis, clone BRAMY3014555;												0						TGAGTTTGATGGTGACCTGGA	0.532			NA											19	82					2.94398e-08	1.12354e-07	0.000958276	1	0
MTPAP	55149	broad.mit.edu	37	10	30615418	30615418	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:30615418C>A	uc001iva.3	-	5	990	c.927G>T	c.(925-927)CGG>CGT	p.R309R	MTPAP_uc001ivb.3_Silent_p.R439R	NM_018109	NP_060579	Q9NVV4	PAPD1_HUMAN	PAP associated domain containing 1 precursor	309					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			ovary(1)	1						CGAGCGGACACCGGGCATTTA	0.443			NA											15	108					0.000219431	0.000672226	0.00244969	1	0
RET	5979	broad.mit.edu	37	10	43610004	43610004	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:43610004G>C	uc001jal.2	+	11	2146	c.1956G>C	c.(1954-1956)CTG>CTC	p.L652L	RET_uc001jak.1_Silent_p.L652L|RET_uc010qez.1_Silent_p.L398L	NM_020975	NP_066124	P07949	RET_HUMAN	ret proto-oncogene isoform a	652	Helical; (Potential).				homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity			thyroid(404)|adrenal_gland(20)|lung(9)|large_intestine(5)|breast(4)|ovary(4)|central_nervous_system(3)|urinary_tract(1)|NS(1)	451		Ovarian(717;0.0423)			Sunitinib(DB01268)	CGGTGCTGCTGTCTGCCTTCT	0.627	Melanoma(102;360 522 3376 9752 9881 14372 17251 18341 20876 24662 34807 43144 48149)		1	T|Mis|N|F	H4|PRKAR1A|NCOA4|PCM1|GOLGA5|TRIM33|KTN1|TRIM27|HOOK3	medullary thyroid| papillary thyroid|pheochromocytoma	medullary thyroid| papillary thyroid|pheochromocytoma	Hirschsprung disease		Multiple_Endocrine_Neoplasia_type_2B|Multiple_Endocrine_Neoplasia_type_2A|Familial_Medullary_Thyroid_Carcinoma				8	42					0	0	0.00307968	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819098	50819098	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:50819098G>A	uc001jhw.2	+	1	752	c.312G>A	c.(310-312)GCG>GCA	p.A104A	CHAT_uc001jhv.1_Intron|CHAT_uc001jhx.1_5'Flank|CHAT_uc001jhy.1_5'Flank|CHAT_uc001jia.2_5'Flank|CHAT_uc001jhz.2_5'Flank	NM_003055	NP_003046	Q16572	VACHT_HUMAN	vesicular acetylcholine transporter	104	Lumenal, vesicle (Potential).				neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			ovary(2)	2						CGACAGCTGCGTGGCCAGCGG	0.682			NA											9	30					0	0	0.00448238	0	0
PCDH15	65217	broad.mit.edu	37	10	55582648	55582648	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:55582648C>G	uc001jju.1	-	33	5233	c.4838G>C	c.(4837-4839)GGA>GCA	p.G1613A	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.G1610A|PCDH15_uc010qhw.1_Missense_Mutation_p.G1573A|PCDH15_uc010qhx.1_Missense_Mutation_p.G1544A|PCDH15_uc010qhy.1_Missense_Mutation_p.G1620A|PCDH15_uc010qhz.1_Missense_Mutation_p.G1615A|PCDH15_uc010qia.1_Missense_Mutation_p.G1593A|PCDH15_uc010qib.1_Missense_Mutation_p.G1590A	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1613	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TGTACAGATTCCAGTGTTTTC	0.433			NA								HNSCC(58;0.16)			26	106					0	0	0.00465635	0	0
PCDH15	65217	broad.mit.edu	37	10	55826597	55826597	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:55826597C>A	uc001jju.1	-	18	2535	c.2140G>T	c.(2140-2142)GCT>TCT	p.A714S	PCDH15_uc010qhq.1_Missense_Mutation_p.A719S|PCDH15_uc010qhr.1_Missense_Mutation_p.A714S|PCDH15_uc010qhs.1_Missense_Mutation_p.A726S|PCDH15_uc010qht.1_Missense_Mutation_p.A721S|PCDH15_uc010qhu.1_Missense_Mutation_p.A714S|PCDH15_uc001jjv.1_Missense_Mutation_p.A692S|PCDH15_uc010qhv.1_Missense_Mutation_p.A714S|PCDH15_uc010qhw.1_Missense_Mutation_p.A677S|PCDH15_uc010qhx.1_Missense_Mutation_p.A643S|PCDH15_uc010qhy.1_Missense_Mutation_p.A719S|PCDH15_uc010qhz.1_Missense_Mutation_p.A714S|PCDH15_uc010qia.1_Missense_Mutation_p.A692S|PCDH15_uc010qib.1_Missense_Mutation_p.A692S|PCDH15_uc001jjw.2_Missense_Mutation_p.A714S	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	714	Cadherin 6.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				AACACTGGAGCATTGTCATTG	0.363			NA								HNSCC(58;0.16)			11	75					5.16669e-11	2.18815e-10	0.000978159	1	0
SUPV3L1	6832	broad.mit.edu	37	10	70956824	70956824	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:70956824G>T	uc001jpe.1	+	8	1063	c.1008G>T	c.(1006-1008)ACG>ACT	p.T336T	SUPV3L1_uc010qjd.1_Silent_p.T205T	NM_003171	NP_003162	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 precursor	336					DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			urinary_tract(1)|ovary(1)	2						TGTACACAACGGGGGAGGAAG	0.473			NA											17	86					4.96729e-08	1.87978e-07	0.00121646	1	0
PSAP	5660	broad.mit.edu	37	10	73591639	73591639	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:73591639G>A	uc001jsm.2	-	3	317	c.213C>T	c.(211-213)ACC>ACT	p.T71T		NM_002778	NP_002769	P07602	SAP_HUMAN	prosaposin isoform a preproprotein	71	Saposin B-type 1.				glycosphingolipid metabolic process|lipid transport|platelet activation|platelet degranulation	extracellular space|Golgi apparatus|integral to membrane|lysosomal lumen	enzyme activator activity|lipid binding			ovary(1)	1						CACCAGCTGCGGTGACAACGT	0.517			NA											29	95					0	0	0.0024448	0	0
LRIT2	340745	broad.mit.edu	37	10	85984201	85984201	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:85984201G>T	uc001kcy.2	-	2	788	c.780C>A	c.(778-780)GCC>GCA	p.A260A	LRIT2_uc010qmc.1_Silent_p.A260A	NM_001017924	NP_001017924	A6NDA9	LRIT2_HUMAN	leucine rich repeat containing 22 precursor	260	Ig-like.					integral to membrane				ovary(2)	2						TGGTGATATTGGCACTGGGGG	0.542			NA											13	54					2.31682e-05	7.5241e-05	0.00316338	1	0
RNLS	55328	broad.mit.edu	37	10	90074241	90074241	+	Silent	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:90074241T>C	uc001kfe.2	-	6	993	c.858A>G	c.(856-858)CAA>CAG	p.Q286Q	RNLS_uc010qms.1_Silent_p.Q203Q|RNLS_uc001kfd.2_Silent_p.Q286Q|RNLS_uc009xtj.2_Silent_p.Q118Q	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	renalase isoform 1	286						extracellular region	oxidoreductase activity			ovary(1)	1						GTCTCCATTTTTGGCATTTGG	0.418			NA											24	70					0	0	0.00106085	0	0
KIF20B	9585	broad.mit.edu	37	10	91488933	91488933	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:91488933G>T	uc001kgs.1	+	18	2392	c.2320G>T	c.(2320-2322)GAT>TAT	p.D774Y	KIF20B_uc001kgr.1_Missense_Mutation_p.D734Y|KIF20B_uc001kgt.1_5'UTR	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	774	Potential.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						AAATATAATTGATCAAAAAGA	0.244			NA											9	57					0.000442599	0.0013229	0.000442599	1	0
MYOF	26509	broad.mit.edu	37	10	95141111	95141111	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:95141111G>T	uc001kin.2	-	20	1864	c.1741C>A	c.(1741-1743)CAT>AAT	p.H581N	MYOF_uc001kio.2_Missense_Mutation_p.H568N|MYOF_uc009xue.2_RNA	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	581	Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GTGGCTGAATGAAACACGGCA	0.448			NA											15	43					0.000422831	0.0012751	0.00400662	1	0
LGI1	9211	broad.mit.edu	37	10	95518028	95518028	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:95518028C>A	uc001kjc.3	+	1	463	c.127C>A	c.(127-129)CCT>ACT	p.P43T	LGI1_uc010qnv.1_Missense_Mutation_p.P43T|LGI1_uc001kjd.3_Missense_Mutation_p.P43T|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_RNA	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	43	LRRNT.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				GCCAAAATGCCCTGCCGTGTG	0.463			NA											17	97					6.49762e-13	2.89712e-12	0.00074312	1	0
COL17A1	1308	broad.mit.edu	37	10	105815145	105815145	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:105815145T>A	uc001kxr.2	-	19	1871	c.1702A>T	c.(1702-1704)AGC>TGC	p.S568C	COL17A1_uc010qqv.1_Missense_Mutation_p.S552C	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	568	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GGGCCAGGGCTTCCTCGGAGA	0.353			NA											16	61					0	0	0.00400662	0	0
C10orf79	80217	broad.mit.edu	37	10	105990542	105990542	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:105990542T>A	uc001kxw.2	-	2	241	c.125A>T	c.(124-126)TAC>TTC	p.Y42F	C10orf79_uc001kxx.3_Missense_Mutation_p.Y42F|C10orf79_uc001kxy.1_Missense_Mutation_p.Y42F|C10orf79_uc001kxz.2_Missense_Mutation_p.Y42F	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	42											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		CCCACAAGGGTAGCAAATGGT	0.358			NA											10	72					0	0	0.000673444	0	0
DMBT1	1755	broad.mit.edu	37	10	124396776	124396776	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:124396776C>G	uc001lgk.1	+	51	6609	c.6503C>G	c.(6502-6504)CCG>CGG	p.P2168R	DMBT1_uc001lgl.1_Missense_Mutation_p.P2158R|DMBT1_uc001lgm.1_Missense_Mutation_p.P1540R|DMBT1_uc009xzz.1_Missense_Mutation_p.P2167R|DMBT1_uc010qtx.1_Missense_Mutation_p.P888R|DMBT1_uc009yab.1_Missense_Mutation_p.P871R|DMBT1_uc009yac.1_Missense_Mutation_p.P462R	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2168	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CAGATAACGCCGAACCTGGTG	0.517	Ovarian(182;93 2026 18125 22222 38972)		NA											3	18					0	0	6.4e-05	0	0
MTG1	92170	broad.mit.edu	37	10	135233639	135233639	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr10:135233639G>T	uc001lnd.2	+	11	1079	c.975G>T	c.(973-975)CGG>CGT	p.R325R	MTG1_uc010qve.1_Silent_p.R190R	NM_138384	NP_612393	Q9BT17	MTG1_HUMAN	GTP_binding protein precursor	325						mitochondrion	GTP binding|protein binding			skin(1)	1		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|all cancers(32;1.69e-06)|Epithelial(32;1.94e-06)		ACGTCCTGCGGGGCCACCCCC	0.637			NA											10	20					0.000442599	0.0013229	0.000442599	1	0
MUC5B	727897	broad.mit.edu	37	11	1268767	1268767	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:1268767C>A	uc009ycr.1	+	50	12367	c.12241C>A	c.(12241-12243)CTG>ATG	p.L4081M	MUC5B_uc001ltb.2_Missense_Mutation_p.L3556M	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3553	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCTCGACCCTGCTGCCCAG	0.682			NA											5	41					8.12818e-05	0.000254784	0.00198382	1	0
TRAF6	7189	broad.mit.edu	37	11	36512083	36512083	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:36512083C>A	uc001mwr.1	-	8	1214	c.874G>T	c.(874-876)GTC>TTC	p.V292F	TRAF6_uc001mws.1_Missense_Mutation_p.V292F	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	292	Potential.|Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				AAATTCCGGACCTCTGAGATA	0.483			NA											24	88					2.65835e-16	1.24271e-15	0.00127121	1	0
MADD	8567	broad.mit.edu	37	11	47296557	47296557	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:47296557C>G	uc001ner.1	+	3	697	c.506C>G	c.(505-507)TCC>TGC	p.S169C	MADD_uc001neq.2_Missense_Mutation_p.S169C|MADD_uc001nev.1_Missense_Mutation_p.S169C|MADD_uc001nes.1_Missense_Mutation_p.S169C|MADD_uc001net.1_Missense_Mutation_p.S169C|MADD_uc009yln.1_Missense_Mutation_p.S169C|MADD_uc001neu.1_Missense_Mutation_p.S169C|MADD_uc001nex.2_Missense_Mutation_p.S169C|MADD_uc001nez.2_Missense_Mutation_p.S169C|MADD_uc001new.2_Missense_Mutation_p.S169C	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	169					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GGGAGCCGCTCCCGCAACAGT	0.602			NA											7	33					0	0	0.00448238	0	0
OR4B1	119765	broad.mit.edu	37	11	48238420	48238420	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:48238420C>A	uc010rhs.1	+	1	59	c.59C>A	c.(58-60)GCT>GAT	p.A20D		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	20	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						CAGGATCCAGCTGTGCAGAGT	0.507			NA											17	67					1.78486e-19	8.52067e-19	0.000958276	1	0
OR4A16	81327	broad.mit.edu	37	11	55110821	55110821	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55110821G>T	uc010rie.1	+	1	145	c.145G>T	c.(145-147)GGC>TGC	p.G49C		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						GACTACTATTGGCAGCCCCTC	0.413			NA											19	87					2.94398e-08	1.12354e-07	0.000958276	1	0
OR4A16	81327	broad.mit.edu	37	11	55111429	55111429	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55111429C>A	uc010rie.1	+	1	753	c.753C>A	c.(751-753)CCC>CCA	p.P251P		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TTTTTGTTCCCTGTATTTTTA	0.373			NA											12	57					9.31168e-06	3.09854e-05	0.00185496	1	0
OR5M9	390162	broad.mit.edu	37	11	56230095	56230095	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:56230095G>T	uc010rjj.1	-	1	783	c.783C>A	c.(781-783)CCC>CCA	p.P261P		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	261	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					ATTCCTCAGTGGGTCTCCTGA	0.493			NA											8	38					0.000157383	0.000488793	0.00307968	1	0
OR5B3	441608	broad.mit.edu	37	11	58170847	58170847	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:58170847A>T	uc010rkf.1	-	1	36	c.36T>A	c.(34-36)CTT>CTA	p.L12L		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TTAGTCCTAGAAGAATGAATT	0.383			NA											19	89					0	0	0.00152264	0	0
GLYAT	10249	broad.mit.edu	37	11	58478071	58478071	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:58478071G>T	uc001nnb.2	-	5	635	c.480C>A	c.(478-480)CCC>CCA	p.P160P	GLYAT_uc001nnc.2_Silent_p.P160P	NM_201648	NP_964011	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase isoform a	160					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity				0		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	ACATGGCCTTGGGTTTGCCAC	0.323			NA											12	67					8.00594e-06	2.67723e-05	0.000958276	1	0
TCN1	6947	broad.mit.edu	37	11	59630179	59630179	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:59630179C>A	uc001noj.2	-	3	374	c.276G>T	c.(274-276)TCG>TCT	p.S92S		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	92					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAAGCTCTCCCGAGCTTACAT	0.388			NA											21	67					5.45024e-15	2.52167e-14	0.00332997	1	0
PICALM	8301	broad.mit.edu	37	11	85692255	85692255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:85692255G>A	uc001pbm.2	-	17	1982	c.1696C>T	c.(1696-1698)CAA>TAA	p.Q566*	PICALM_uc001pbl.2_Nonsense_Mutation_p.Q516*|PICALM_uc001pbn.2_Nonsense_Mutation_p.Q559*|PICALM_uc010rtl.1_Nonsense_Mutation_p.Q465*|PICALM_uc001pbk.2_RNA|PICALM_uc010rtk.1_Nonsense_Mutation_p.Q143*|PICALM_uc001pbo.1_Nonsense_Mutation_p.Q198*	NM_007166	NP_009097	Q13492	PICAL_HUMAN	phosphatidylinositol-binding clathrin assembly	566					clathrin coat assembly|endosome transport|negative regulation of receptor-mediated endocytosis|positive regulation of transcription, DNA-dependent|receptor internalization|regulation of protein localization	clathrin coat|clathrin-coated vesicle|coated pit|Golgi apparatus|nucleus|postsynaptic membrane|presynaptic membrane	1-phosphatidylinositol binding|clathrin heavy chain binding			urinary_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(157;7.42e-07)|all_hematologic(158;0.00092)				TCACCTGGTTGACTCCAATTT	0.353			NA	T	MLLT10|MLL	TALL|AML|								17	53					0	0	0.00074312	0	0
ENDOD1	23052	broad.mit.edu	37	11	94862474	94862474	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:94862474C>T	uc001pfh.2	+	2	1309	c.1234C>T	c.(1234-1236)CTC>TTC	p.L412F		NM_015036	NP_055851	O94919	ENDD1_HUMAN	endonuclease domain containing 1 precursor	412						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding				0		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				CATCAGGGCTCTCCTCCGGAT	0.552			NA											12	69					0	0	0.000978159	0	0
EXPH5	23086	broad.mit.edu	37	11	108384345	108384345	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:108384345G>A	uc001pkk.2	-	6	2000	c.1889C>T	c.(1888-1890)TCC>TTC	p.S630F	EXPH5_uc010rvy.1_Missense_Mutation_p.S442F|EXPH5_uc010rvz.1_Missense_Mutation_p.S474F|EXPH5_uc010rwa.1_Missense_Mutation_p.S554F	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	630					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		CTGGGAAAAGGAAGTTTTGAA	0.408			NA											8	115					0	0	0.000442599	0	0
OR10G7	390265	broad.mit.edu	37	11	123909438	123909438	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:123909438T>C	uc001pzq.1	-	1	271	c.271A>G	c.(271-273)ATC>GTC	p.I91V		NM_001004463	NP_001004463	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGGAAGGAGATAGTCCTGCCG	0.527			NA											21	118					0	0	0.00278032	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839603	128839603	+	Silent	SNP	G	G	T	rs79505038	by1000genomes	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:128839603G>T	uc009zcp.2	-	22	5463	c.5463C>A	c.(5461-5463)CCC>CCA	p.P1821P	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Silent_p.P780P|ARHGAP32_uc001qez.2_Silent_p.P1472P	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	1821	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CCTCTCCCTCGGGACTGATGG	0.577			NA											5	46					0.00116845	0.00343167	0.00116845	1	0
CACNA2D4	93589	broad.mit.edu	37	12	1965194	1965194	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:1965194C>T	uc001qjp.2	-	22	2367	c.2136G>A	c.(2134-2136)AAG>AAA	p.K712K	CACNA2D4_uc009zds.1_RNA|CACNA2D4_uc009zdt.1_Silent_p.K576K|CACNA2D4_uc009zdr.1_5'Flank	NM_172364	NP_758952	Q7Z3S7	CA2D4_HUMAN	voltage-gated calcium channel alpha(2)delta-4	712	Extracellular (Potential).					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			ovary(1)	1	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGTCTGGGTCCTTCCTGGTGA	0.577	Colon(2;101 179 21030 23310 28141)		NA											5	25					0	0	0.000602214	0	0
CACNA1C	775	broad.mit.edu	37	12	2791158	2791158	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:2791158G>T	uc009zdu.1	+	45	5944	c.5631G>T	c.(5629-5631)AGG>AGT	p.R1877S	CACNA1C_uc009zdv.1_Intron|CACNA1C_uc001qkb.2_Intron|CACNA1C_uc001qkc.2_Intron|CACNA1C_uc001qke.2_Intron|CACNA1C_uc001qkf.2_Intron|CACNA1C_uc001qjz.2_Intron|CACNA1C_uc001qkd.2_Intron|CACNA1C_uc001qkg.2_Intron|CACNA1C_uc009zdw.1_Intron|CACNA1C_uc001qkh.2_Intron|CACNA1C_uc001qkl.2_Intron|CACNA1C_uc001qkn.2_Intron|CACNA1C_uc001qko.2_Intron|CACNA1C_uc001qkp.2_Intron|CACNA1C_uc001qkr.2_Intron|CACNA1C_uc001qku.2_Missense_Mutation_p.R1829S|CACNA1C_uc001qkq.2_Intron|CACNA1C_uc001qks.2_Intron|CACNA1C_uc001qkt.2_Intron|CACNA1C_uc001qki.1_Intron|CACNA1C_uc001qkj.1_Missense_Mutation_p.R1565S|CACNA1C_uc001qkk.1_Intron|CACNA1C_uc001qkm.1_Intron|CACNA1C_uc010sea.1_Intron|uc001qkx.1_Intron|CACNA1C_uc001qky.1_Intron	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	1877	Cytoplasmic (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGCTCAGGAGGGATTCAGGCT	0.572			NA											6	47					5.9392e-07	2.12271e-06	0.00116845	1	0
ZNF384	171017	broad.mit.edu	37	12	6776900	6776900	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:6776900C>T	uc010sfh.1	-	11	1922	c.1714G>A	c.(1714-1716)GAG>AAG	p.E572K	ZNF384_uc001qpz.2_Missense_Mutation_p.E511K|ZNF384_uc001qqa.2_Missense_Mutation_p.E511K|ZNF384_uc001qqb.2_Missense_Mutation_p.E495K|ZNF384_uc001qqc.2_Missense_Mutation_p.E511K|ZNF384_uc001qqd.2_Missense_Mutation_p.E456K|ZNF384_uc001qqe.2_Missense_Mutation_p.E495K	NM_001135734	NP_001129206	Q8TF68	ZN384_HUMAN	nuclear matrix transcription factor 4 isoform d	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		EWSR1/ZNF384(4)	haematopoietic_and_lymphoid_tissue(4)|central_nervous_system(3)|kidney(1)	8						GCCAGGTGCTCCACCTGGATG	0.557			NA	T	EWSR1|TAF15 	ALL								12	109					0	0	0.000978159	0	0
CD163	9332	broad.mit.edu	37	12	7632483	7632483	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:7632483C>T	uc001qsz.3	-	16	3581	c.3453G>A	c.(3451-3453)AAG>AAA	p.K1151K	CD163_uc001qta.3_3'UTR|CD163_uc009zfw.2_3'UTR	NM_004244	NP_004235	Q86VB7	C163A_HUMAN	CD163 antigen isoform a	1151	Cytoplasmic (Potential).				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			ovary(6)|pancreas(1)|skin(1)	8						TCCCATTTTCCTTTTCAGTGT	0.403			NA											17	63					0	0	0.000566183	0	0
SLC2A14	144195	broad.mit.edu	37	12	7984305	7984305	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:7984305G>T	uc001qtk.2	-	9	1029	c.236C>A	c.(235-237)TCT>TAT	p.S79Y	SLC2A14_uc001qtl.2_Missense_Mutation_p.S56Y|SLC2A14_uc001qtm.2_Missense_Mutation_p.S56Y|SLC2A14_uc010sgg.1_Intron|SLC2A14_uc001qtn.2_Missense_Mutation_p.S79Y|SLC2A14_uc001qto.2_Intron|SLC2A14_uc010sgh.1_Missense_Mutation_p.S94Y	NM_153449	NP_703150	Q8TDB8	GTR14_HUMAN	glucose transporter 14	79	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane	glucose transmembrane transporter activity			ovary(1)	1				Kidney(36;0.0883)		CAGCACCTCAGAGGGAGGGGC	0.463			NA									OREG0021654	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	53					6.31663e-08	2.36392e-07	0.00316338	1	0
ZNF705A	440077	broad.mit.edu	37	12	8329900	8329900	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:8329900C>A	uc001qud.1	+	5	696	c.624C>A	c.(622-624)GCC>GCA	p.A208A	FAM66C_uc001que.3_5'Flank|FAM66C_uc001quf.3_5'Flank|FAM66C_uc009zgc.2_5'Flank|FAM66C_uc001qug.3_5'Flank	NM_001004328	NP_001004328	Q6ZN79	Z705A_HUMAN	zinc finger protein 705A	208	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				Kidney(36;0.0877)		GTGGAAAAGCCTTCACTCAGT	0.423			NA											27	82					6.70999e-13	2.98197e-12	0.00428921	1	0
PZP	5858	broad.mit.edu	37	12	9353608	9353608	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:9353608C>A	uc001qvl.2	-	6	579	c.550G>T	c.(550-552)GCT>TCT	p.A184S	PZP_uc009zgl.2_Missense_Mutation_p.A53S	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TTGATGCCAGCTTCTAGCTTG	0.478	Melanoma(125;1402 1695 4685 34487 38571)		NA											18	87					1.50039e-11	6.49688e-11	0.00188189	1	0
PTPRO	5800	broad.mit.edu	37	12	15669860	15669861	+	Missense_Mutation	DNP	AG	AG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:15669860_15669861AG>TT	uc001rcv.1	+	9	1923_1924	c.1749_1750AG>TT	c.(1747-1752)ATAGCA>ATTTCA	p.A584S	PTPRO_uc001rcw.1_Missense_Mutation_p.A584S|PTPRO_uc001rcu.1_Missense_Mutation_p.A584S	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	584	Fibronectin type-III 6.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				ACTATGAAATAGCAGCAACTGT	0.416			NA											31	113					0	0	6.4e-05	0	0
SOX5	6660	broad.mit.edu	37	12	23818489	23818489	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:23818489G>A	uc001rfw.2	-	7	922	c.820C>T	c.(820-822)CAG>TAG	p.Q274*	SOX5_uc001rfx.2_Nonsense_Mutation_p.Q261*|SOX5_uc001rfy.2_Nonsense_Mutation_p.Q261*|SOX5_uc010siv.1_Nonsense_Mutation_p.Q261*|SOX5_uc010siw.1_RNA|SOX5_uc001rfz.1_Nonsense_Mutation_p.Q226*	NM_006940	NP_008871	P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5 isoform a	274	Potential.				transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(5)|lung(1)	6						GGCGGCAGCTGACCTTGAACC	0.483			NA											20	63					0	0	0.00188189	0	0
Unknown	0	broad.mit.edu	37	12	31301909	31301909	+	Splice_Site	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:31301909T>A	uc010sjy.1	-	10	1045	c.1045_splice	c.e10-1	p.L349_splice						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						AAATTTAAGCTGTACAAGAAA	0.303			NA											4	24					0	0	0.00024832	0	0
SYT10	341359	broad.mit.edu	37	12	33579112	33579112	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:33579112C>A	uc001rll.1	-	2	767	c.470G>T	c.(469-471)CGT>CTT	p.R157L	SYT10_uc009zju.1_5'UTR	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	157	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TCTTTGCACACGTGCATGTTT	0.318			NA											41	175					2.47872e-24	1.2357e-23	0.0025221	1	0
CNTN1	1272	broad.mit.edu	37	12	41316083	41316083	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:41316083G>T	uc001rmm.1	+	5	366	c.253G>T	c.(253-255)GAT>TAT	p.D85Y	CNTN1_uc009zjy.1_Missense_Mutation_p.D85Y|CNTN1_uc001rmn.1_Missense_Mutation_p.D74Y|CNTN1_uc001rmo.2_Missense_Mutation_p.D85Y	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	85	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TGGGGACGTTGATCTCACAAG	0.393			NA											17	54					7.45023e-12	3.26794e-11	0.00152264	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43777718	43777718	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:43777718A>G	uc010skx.1	-	30	4515	c.4515T>C	c.(4513-4515)GTT>GTC	p.V1505V		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1505	TSP type-1 12.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCACCTGACCAACACCTTTCA	0.488			NA											6	38					0	0	0.00116845	0	0
DBX2	440097	broad.mit.edu	37	12	45417504	45417504	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:45417504G>T	uc001rok.1	-	3	845	c.673C>A	c.(673-675)CTA>ATA	p.L225I		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	225	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GATTCCTTTAGTCCCAAGTTG	0.303			NA											43	197					1.91693e-13	8.69051e-13	0.00361006	1	0
KRT6B	3854	broad.mit.edu	37	12	52845722	52845722	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:52845722C>A	uc001sak.2	-	1	189	c.141G>T	c.(139-141)CTG>CTT	p.L47L		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	47	Head.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		ATGCGCCACCCAGGCCACCAC	0.667			NA											8	68					1.08611e-07	3.99818e-07	0.000978159	1	0
OR10A7	121364	broad.mit.edu	37	12	55615378	55615378	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:55615378G>A	uc010spf.1	+	1	570	c.570G>A	c.(568-570)GTG>GTA	p.V190V		NM_001005280	NP_001005280	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)	4						TAGTCACAGTGGATACAACCA	0.448			NA											14	57					0	0	0.00185496	0	0
LGR5	8549	broad.mit.edu	37	12	71898402	71898402	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:71898402G>T	uc001swl.2	+	2	269	c.221G>T	c.(220-222)AGT>ATT	p.S74I	LGR5_uc001swm.2_Missense_Mutation_p.S74I|LGR5_uc001swn.1_RNA	NM_003667	NP_003658	O75473	LGR5_HUMAN	leucine-rich repeat-containing G protein-coupled	74	LRR 1.|Extracellular (Potential).					integral to plasma membrane	protein-hormone receptor activity			lung(4)|skin(3)|ovary(1)|pancreas(1)	9						AGAGACCTCAGTATGAACAAC	0.493			NA											43	193					2.51966e-14	1.1618e-13	0.00361006	1	0
RPH3A	22895	broad.mit.edu	37	12	113319615	113319615	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:113319615C>A	uc010syl.1	+	15	1652	c.1290C>A	c.(1288-1290)CCC>CCA	p.P430P	RPH3A_uc001ttz.2_Silent_p.P430P|RPH3A_uc001tty.2_Silent_p.P426P|RPH3A_uc009zwe.1_Silent_p.P426P|RPH3A_uc010sym.1_Silent_p.P381P|RPH3A_uc001tua.2_Silent_p.P190P	NM_001143854	NP_001137326	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog isoform 1	430	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			ovary(3)|central_nervous_system(2)|skin(2)	7				BRCA - Breast invasive adenocarcinoma(302;0.00453)		TGGCTGATCCCTACGTTAAGC	0.607			NA											14	49					1.3612e-06	4.77659e-06	0.00316338	1	0
MED13L	23389	broad.mit.edu	37	12	116413011	116413011	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:116413011C>A	uc001tvw.2	-	25	5751	c.5696G>T	c.(5695-5697)GGG>GTG	p.G1899V		NM_015335	NP_056150	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1899					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					skin(4)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	8	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		CCCAAGTCGCCCGATTACAAC	0.443			NA											9	62					7.48243e-07	2.65322e-06	0.000442599	1	0
CCDC60	160777	broad.mit.edu	37	12	119937958	119937958	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:119937958C>G	uc001txe.2	+	6	1098	c.633C>G	c.(631-633)TTC>TTG	p.F211L	uc001txf.2_Intron	NM_178499	NP_848594	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	211										ovary(2)|upper_aerodigestive_tract(1)	3	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		GGGAGCATTTCATCACAGCGC	0.468			NA											14	47					0	0	0.00244969	0	0
PITPNM2	57605	broad.mit.edu	37	12	123477210	123477210	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr12:123477210T>A	uc001uej.1	-	15	2379	c.2240A>T	c.(2239-2241)CAG>CTG	p.Q747L	PITPNM2_uc001uek.1_Missense_Mutation_p.Q747L	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	747	DDHD.				metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		CGGCCGCAGCTGGAAAACTGG	0.662			NA											3	14					0	0	6.4e-05	0	0
SACS	26278	broad.mit.edu	37	13	23904603	23904603	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:23904603T>A	uc001uon.2	-	10	14001	c.13412A>T	c.(13411-13413)GAG>GTG	p.E4471V	SACS_uc001uoo.2_Missense_Mutation_p.E4324V|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4471	HEPN.				cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		GCACACCCACTCATTGGCATT	0.443			NA											35	125					0	0	0.000953801	0	0
PARP4	143	broad.mit.edu	37	13	25021220	25021220	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:25021220G>A	uc001upl.2	-	26	3325	c.3219C>T	c.(3217-3219)GCC>GCT	p.A1073A		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1073					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		ACGGCACCTGGGCTGGGGCCT	0.512			NA											6	68					0	0	0.00198382	0	0
N4BP2L2	10443	broad.mit.edu	37	13	33110497	33110497	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:33110497T>C	uc001uuk.3	-	2	846	c.668A>G	c.(667-669)GAT>GGT	p.D223G	N4BP2L2_uc010abe.1_Intron|N4BP2L2_uc010tdz.1_Intron|N4BP2L2_uc001uul.1_Missense_Mutation_p.D223G|N4BP2L2_uc001uum.2_5'Flank	NM_014887	NP_055702	Q92802	N42L2_HUMAN	phosphonoformate immuno-associated protein 5	223											0		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		ATTACTAAGATCTTTCTTTTC	0.353			NA											11	73					0	0	0.00136819	0	0
NBEA	26960	broad.mit.edu	37	13	36228995	36228995	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:36228995A>G	uc001uvb.2	+	53	8182	c.7976A>G	c.(7975-7977)AAT>AGT	p.N2659S	NBEA_uc010abi.2_Missense_Mutation_p.N1315S|NBEA_uc010tef.1_Missense_Mutation_p.N452S|NBEA_uc001uvd.2_Missense_Mutation_p.N237S	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	2659						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTTTTAGCCAATAATTCAGGT	0.348			NA											4	25					0	0	0.00024832	0	0
EPSTI1	94240	broad.mit.edu	37	13	43474446	43474446	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:43474446C>A	uc001uyw.1	-	10	924	c.848G>T	c.(847-849)AGG>ATG	p.R283M	EPSTI1_uc001uyx.1_Missense_Mutation_p.R272M	NM_001002264	NP_001002264	Q96J88	ESIP1_HUMAN	epithelial stromal interaction 1 isoform 1	283										ovary(1)	1		Lung NSC(96;3.6e-06)|Breast(139;0.00869)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		GBM - Glioblastoma multiforme(144;0.000528)|BRCA - Breast invasive adenocarcinoma(63;0.0858)		CCAGTTTTACCTCCTGTGTTC	0.343			NA											12	43					4.3838e-07	1.58781e-06	0.00185496	1	0
SERPINE3	647174	broad.mit.edu	37	13	51922467	51922467	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:51922467C>T	uc001vfh.2	+	4	879	c.819C>T	c.(817-819)ATC>ATT	p.I273I	SERPINE3_uc010tgp.1_Silent_p.I273I	NM_001101320	NP_001094790	A8MV23	SERP3_HUMAN	nexin-related serine protease inhibitor	273					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						TGAGCCACATCGAGCCACACC	0.622			NA											6	18					0	0	0.00198382	0	0
THSD1	55901	broad.mit.edu	37	13	52951957	52951957	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:52951957A>G	uc001vgo.2	-	5	2693	c.2148T>C	c.(2146-2148)AGT>AGC	p.S716S	THSD1_uc001vgp.2_Silent_p.S663S|THSD1_uc010tgz.1_Silent_p.S337S|THSD1_uc010aea.2_Silent_p.S177S	NM_018676	NP_061146	Q9NS62	THSD1_HUMAN	thrombospondin type I domain-containing 1	716	Cytoplasmic (Potential).					extracellular region|integral to membrane|intracellular membrane-bounded organelle				ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		Breast(56;0.000207)|Lung NSC(96;0.00145)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.8e-08)		CACGGGTTCCACTTGCCTCTT	0.557			NA											9	40					0	0	0.000673444	0	0
PCDH9	5101	broad.mit.edu	37	13	67205364	67205364	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:67205364A>G	uc001vik.2	-	4	4010	c.3318T>C	c.(3316-3318)GAT>GAC	p.D1106D	PCDH9_uc010aei.2_RNA|PCDH9_uc001vil.2_Silent_p.D1072D|PCDH9_uc010thl.1_Silent_p.D1064D	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	1106	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CAGAGTTGCCATCTGCTTCAG	0.478			NA											11	80					0	0	0.00136819	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455447	84455447	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:84455447G>T	uc001vlk.2	-	1	1082	c.196C>A	c.(196-198)CAT>AAT	p.H66N		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	66	LRR 1.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GAATTGCCATGCAGAAATAAA	0.438			NA											13	65					1.61879e-10	6.70855e-10	0.00136819	1	0
OXGR1	27199	broad.mit.edu	37	13	97639970	97639970	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:97639970G>T	uc001vmx.1	-	4	288	c.44C>A	c.(43-45)CCC>CAC	p.P15H	OXGR1_uc010afr.1_Missense_Mutation_p.P15H	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	15	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TGCATAATCGGGGAAATCAGA	0.403			NA											18	88					1.28384e-07	4.71322e-07	0.00188189	1	0
ABHD13	84945	broad.mit.edu	37	13	108881821	108881821	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:108881821A>G	uc001vqq.2	+	2	520	c.255A>G	c.(253-255)CCA>CCG	p.P85P		NM_032859	NP_116248	Q7L211	ABHDD_HUMAN	abhydrolase domain containing 13	85						integral to membrane	hydrolase activity	p.P85L(1)		ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CTGGCATTCCACATGAAAACA	0.378	Pancreas(22;506 789 38166 45896 51596)		NA											22	133					0	0	0.00332997	0	0
NFKBIA	4792	broad.mit.edu	37	14	35873698	35873698	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:35873698C>T	uc001wtf.3	-	1	263	c.153G>A	c.(151-153)GAG>GAA	p.E51E	NFKBIA_uc001wte.3_5'Flank|NFKBIA_uc001wtg.3_Silent_p.E51E|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	51	Nuclear export signal.			MVKELQEI->AAKEAQEA: No nuclear export.	anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		CGAGGCGGATCTCCTGCAGCT	0.677			NA											5	11					0	0	0.00116845	0	0
RGS6	9628	broad.mit.edu	37	14	72939605	72939605	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:72939605G>A	uc001xna.3	+	9	1085	c.562G>A	c.(562-564)GAA>AAA	p.E188K	RGS6_uc010ttn.1_Missense_Mutation_p.E188K|RGS6_uc001xmx.3_Missense_Mutation_p.E188K|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.E188K|RGS6_uc010ttp.1_Missense_Mutation_p.E119K|RGS6_uc001xmz.1_Missense_Mutation_p.E49K|RGS6_uc010arg.2_RNA	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	188					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		AGACAAGACAGAAAGGAAAAT	0.398	Ovarian(143;1926 2468 21071 48641)		NA											68	154					0	0	0.00361006	0	0
YLPM1	56252	broad.mit.edu	37	14	75264921	75264921	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:75264921C>T	uc001xqj.3	+	5	3045	c.2921C>T	c.(2920-2922)TCA>TTA	p.S974L	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		GTAGCAACATCATCATTAACA	0.448			NA											22	36					0	0	0.00395357	0	0
TSHR	7253	broad.mit.edu	37	14	81610628	81610628	+	Silent	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:81610628T>A	uc001xvd.1	+	10	2382	c.2226T>A	c.(2224-2226)ATT>ATA	p.I742I		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	742	Cytoplasmic (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	ATGAACTGATTGAAAACTCCC	0.438			NA	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						38	67					0	0	0.00195071	0	0
EML5	161436	broad.mit.edu	37	14	89091321	89091321	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:89091321C>G	uc001xxg.2	-	36	5077	c.4891G>C	c.(4891-4893)GAA>CAA	p.E1631Q	EML5_uc001xxf.2_Missense_Mutation_p.E418Q|EML5_uc001xxh.1_Missense_Mutation_p.E762Q	NM_183387	NP_899243	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like	1623	WD 24.					cytoplasm|microtubule				ovary(3)	3						CACGGCCTTTCCTTTCCCCCA	0.453			NA											9	17					0	0	0.00448238	0	0
SLC12A6	9990	broad.mit.edu	37	15	34528271	34528271	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:34528271G>A	uc001zhw.2	-	23	3336	c.3172C>T	c.(3172-3174)CGG>TGG	p.R1058W	SLC12A6_uc001zhv.2_Missense_Mutation_p.R1007W|SLC12A6_uc001zhx.2_Missense_Mutation_p.R1043W|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.R999W|SLC12A6_uc001zib.2_Missense_Mutation_p.R1049W|SLC12A6_uc001zic.2_Missense_Mutation_p.R1058W|SLC12A6_uc010bau.2_Missense_Mutation_p.R1058W|SLC12A6_uc001zid.2_Missense_Mutation_p.R999W|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.R870W	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	1058	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	TTTTGTCCCCGGGATGCCATG	0.458			NA											8	83					0	0	0.00307968	0	0
FBN1	2200	broad.mit.edu	37	15	48808532	48808532	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:48808532G>A	uc001zwx.1	-	11	1503	c.1175C>T	c.(1174-1176)CCT>CTT	p.P392L		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	392					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AATTACCATAGGAACAGAGCA	0.483			NA											15	34					0	0	0.00316338	0	0
NTRK3	4916	broad.mit.edu	37	15	88476310	88476310	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:88476310C>A	uc002bme.1	-	15	1984	c.1822G>T	c.(1822-1824)GGC>TGC	p.G608C	NTRK3_uc002bmh.2_Missense_Mutation_p.G600C|NTRK3_uc002bmf.1_Missense_Mutation_p.G608C|NTRK3_uc010upl.1_Missense_Mutation_p.G510C|NTRK3_uc010bnh.1_Missense_Mutation_p.G600C	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	608	Cytoplasmic (Potential).|Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.G608S(2)	ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCCCCATCGCCGCACACTCCA	0.547			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			10	21					0.000442599	0.0013229	0.000442599	1	0
LINS1	55180	broad.mit.edu	37	15	101109855	101109855	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr15:101109855C>A	uc002bwe.2	-	8	2153	c.1862G>T	c.(1861-1863)CGG>CTG	p.R621L	LINS1_uc002bwd.2_Missense_Mutation_p.R208L|LINS1_uc002bwf.2_Missense_Mutation_p.R621L|LINS1_uc002bwg.2_Missense_Mutation_p.R621L|LINS1_uc002bwh.2_Missense_Mutation_p.R621L	NM_001040614	NP_001035704	Q8NG48	LINES_HUMAN	lines homolog 1	621											0	Lung NSC(78;0.0018)|all_lung(78;0.00223)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.00095)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)			TTGAGAGGCCCGGGGGGAAGA	0.527			NA											5	64					0.00116845	0.00343167	0.00116845	1	0
CRAMP1L	57585	broad.mit.edu	37	16	1718043	1718043	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:1718043G>C	uc010uvh.1	+	17	3183	c.3183G>C	c.(3181-3183)GAG>GAC	p.E1061D	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	1061						nucleus	DNA binding				0						CCTCGTCAGAGAGCTCCAGCA	0.617			NA											3	21					0	0	6.4e-05	0	0
ABCC6	368	broad.mit.edu	37	16	16276354	16276354	+	Missense_Mutation	SNP	C	C	A	rs72650701		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:16276354C>A	uc002den.3	-	17	2199	c.2162G>T	c.(2161-2163)TGG>TTG	p.W721L	ABCC6_uc010bvo.2_RNA	NM_001171	NP_001162	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C, member 6	721	ABC transporter 1.|Cytoplasmic (By similarity).				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(2)|ovary(1)	3				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		TCTCTCCAGCCAGGGTGGGTC	0.592			NA											11	28					0.000673444	0.00199523	0.000673444	1	0
ACSM5	54988	broad.mit.edu	37	16	20441082	20441082	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:20441082A>T	uc002dhe.2	+	8	1231	c.1084A>T	c.(1084-1086)ACT>TCT	p.T362S		NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	362					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						GAAACACCAGACTGGTGTGGA	0.592			NA											4	38					0	0	0.000602214	0	0
ACSM2A	123876	broad.mit.edu	37	16	20482880	20482880	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:20482880G>C	uc010bwe.2	+	7	1002	c.763G>C	c.(763-765)GAT>CAT	p.D255H	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Missense_Mutation_p.D176H|ACSM2A_uc002dhf.3_Missense_Mutation_p.D255H|ACSM2A_uc002dhg.3_Missense_Mutation_p.D255H|ACSM2A_uc010vay.1_Missense_Mutation_p.D176H	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	255					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						GCAAGCCTCTGATATAATGTG	0.458			NA											22	118					0	0	0.0024448	0	0
DNAH3	55567	broad.mit.edu	37	16	21048036	21048036	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:21048036C>A	uc010vbe.1	-	35	5085	c.5085G>T	c.(5083-5085)CAG>CAT	p.Q1695H		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1695	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AGGAACCAACCTGGATAATTT	0.383			NA											18	55					2.94398e-08	1.12354e-07	0.000958276	1	0
DNAH3	55567	broad.mit.edu	37	16	21073854	21073854	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:21073854C>A	uc010vbe.1	-	25	3669	c.3669G>T	c.(3667-3669)TCG>TCT	p.S1223S		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1223	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTTCTTTTTCCGAGCTGATCA	0.428			NA											24	111					1.85244e-09	7.40428e-09	0.00332997	1	0
CDH16	1014	broad.mit.edu	37	16	66950032	66950032	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:66950032A>T	uc002eql.2	-	5	433	c.360T>A	c.(358-360)AAT>AAA	p.N120K	CDH16_uc010cdy.2_Missense_Mutation_p.N120K|CDH16_uc002eqm.2_Missense_Mutation_p.N120K	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	120	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCACCTGGTCATTCTCATCCT	0.577			NA											7	32					0	0	0.00307968	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67320659	67320659	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:67320659T>C	uc002eso.3	+	16	5297	c.2762T>C	c.(2761-2763)CTC>CCC	p.L921P	PLEKHG4_uc002esp.3_Missense_Mutation_p.L728P|PLEKHG4_uc002esq.3_Missense_Mutation_p.L921P|PLEKHG4_uc010cef.2_Missense_Mutation_p.L921P|PLEKHG4_uc002ess.3_Missense_Mutation_p.L921P|PLEKHG4_uc010ceg.2_Missense_Mutation_p.L840P	NM_015432	NP_056247	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G	921	PH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)|pancreas(1)	2				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		CAGGTTAACCTCAAGGAACAG	0.602			NA											4	12					0	0	0.00024832	0	0
SF3B3	23450	broad.mit.edu	37	16	70595659	70595659	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:70595659A>G	uc002ezf.2	+	17	2471	c.2260A>G	c.(2260-2262)ATT>GTT	p.I754V		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	754					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				TCCCGAGGGCATTGTGGCCAT	0.527			NA											16	53					0	0	0.00400662	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401440	77401440	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:77401440C>A	uc002ffc.3	-	4	1095	c.676G>T	c.(676-678)GGT>TGT	p.G226C	ADAMTS18_uc002ffe.1_5'UTR|ADAMTS18_uc010vni.1_RNA	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	226					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						GGGGAGTAACCAGGATAATTC	0.537			NA											11	30					0.00010058	0.000314545	0.00136819	1	0
GAN	8139	broad.mit.edu	37	16	81388292	81388292	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr16:81388292G>T	uc002fgo.2	+	3	713	c.565G>T	c.(565-567)GTT>TTT	p.V189F		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	189	BACK.				cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				GAAGTTAAACGTTGGCAATGA	0.383	GBM(106;1239 1507 7582 9741 33976)		NA											29	75					9.39395e-14	4.30211e-13	0.00106085	1	0
TP53	7157	broad.mit.edu	37	17	7577570	7577570	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:7577570C>T	uc002gim.2	-	7	905	c.711G>A	c.(709-711)ATG>ATA	p.M237I	TP53_uc002gig.1_Missense_Mutation_p.M237I|TP53_uc002gih.2_Missense_Mutation_p.M237I|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.M105I|TP53_uc010cng.1_Missense_Mutation_p.M105I|TP53_uc002gii.1_Missense_Mutation_p.M105I|TP53_uc010cnh.1_Missense_Mutation_p.M237I|TP53_uc010cni.1_Missense_Mutation_p.M237I|TP53_uc002gij.2_Missense_Mutation_p.M237I|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.M144I|TP53_uc002gio.2_Missense_Mutation_p.M105I	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	237	|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		M -> L (in sporadic cancers; somatic mutation).|M -> K (in sporadic cancers; somatic mutation).|M -> I (in LFS; germline mutation and in sporadic cancers; somatic mutation).|M -> R (in sporadic cancers; somatic mutation).|M -> T (in sporadic cancers; somatic mutation).|M -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.M237I(99)|p.M237K(8)|p.0?(7)|p.M237V(6)|p.M237fs*10(4)|p.M237R(3)|p.M237T(2)|p.M237L(2)|p.Y236_M237delYM(1)|p.Y236_M237insXX(1)|p.M237_N239delMCN(1)|p.H233fs*6(1)|p.M144I(1)|p.Y236_M243delYMCNSSCM(1)|p.C238fs*2(1)|p.V225fs*23(1)|p.M237_C238insX(1)|p.Y236_M237>*L(1)|p.H233_C242del10(1)|p.M237fs*1(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AACTGTTACACATGTAGTTGT	0.567	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	34					0	0	0.00448238	0	0
FLCN	201163	broad.mit.edu	37	17	17122418	17122418	+	Missense_Mutation	SNP	G	G	T	rs138031155	byFrequency	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:17122418G>T	uc002gra.3	-	9	1481	c.977C>A	c.(976-978)CCG>CAG	p.P326Q	PLD6_uc010cpn.2_Intron	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	326					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						GGACTCTGCCGGGCCCTGGGT	0.627			NA							Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				21	79					5.35356e-11	2.25316e-10	0.00278032	1	0
ULK2	9706	broad.mit.edu	37	17	19687150	19687150	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:19687150C>A	uc002gwm.3	-	22	2829	c.2320G>T	c.(2320-2322)GGC>TGC	p.G774C	ULK2_uc002gwn.2_Missense_Mutation_p.G774C	NM_001142610	NP_001136082	Q8IYT8	ULK2_HUMAN	unc-51-like kinase 2	774					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			skin(2)|large_intestine(1)|stomach(1)	4	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					AAGCCTGGGCCAGGCGGGGAC	0.642			NA											7	20					2.0095e-06	6.9433e-06	0.00198382	1	0
NOS2	4843	broad.mit.edu	37	17	26086080	26086080	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:26086080G>T	uc002gzu.2	-	26	3445	c.3181C>A	c.(3181-3183)CGG>AGG	p.R1061R		NM_000625	NP_000616	P35228	NOS2_HUMAN	nitric oxide synthase 2A	1061					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			skin(2)|ovary(1)|breast(1)	4					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGCTGCTGCCGCAGGATGTCC	0.622			NA											4	12					1.23904e-05	4.04334e-05	0.000602214	1	0
LRRC37B	114659	broad.mit.edu	37	17	30349307	30349307	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:30349307C>G	uc002hgu.2	+	1	1153	c.1142C>G	c.(1141-1143)TCT>TGT	p.S381C	LRRC37B_uc010wbx.1_Missense_Mutation_p.S299C|LRRC37B_uc010csu.2_Missense_Mutation_p.S381C	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	381	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				GAACCTTCTTCTACAGCCCTG	0.547			NA											24	81					0	0	0.00229938	0	0
KRT23	25984	broad.mit.edu	37	17	39092731	39092731	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:39092731C>G	uc002hvm.1	-	2	714	c.125G>C	c.(124-126)CGC>CCC	p.R42P	KRT23_uc010wfl.1_Intron|KRT23_uc010cxf.1_Intron|KRT23_uc010cxg.2_Missense_Mutation_p.R42P|KRT23_uc002hvn.1_Missense_Mutation_p.R42P	NM_015515	NP_056330	Q9C075	K1C23_HUMAN	keratin 23	42	Head.					intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)|Ovarian(249;0.15)				CAGGGAGATGCGGGCTCCCCC	0.706			NA											6	21					0	0	0.00198382	0	0
C17orf57	124989	broad.mit.edu	37	17	45518003	45518003	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:45518003C>A	uc002iln.2	+	25	3256	c.2845C>A	c.(2845-2847)CAC>AAC	p.H949N		NM_152347	NP_689560	Q8IY85	CQ057_HUMAN	hypothetical protein LOC124989	949							calcium ion binding			breast(1)|central_nervous_system(1)|skin(1)	3						TATAAAACAACACAAGATTAG	0.313			NA											14	81					0.000219431	0.000672226	0.00244969	1	0
NXPH3	11248	broad.mit.edu	37	17	47656161	47656161	+	Silent	SNP	G	G	A	rs36092288		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:47656161G>A	uc002ipa.2	+	2	542	c.258G>A	c.(256-258)CCG>CCA	p.P86P	NXPH3_uc010wlw.1_Silent_p.P86P	NM_007225	NP_009156	O95157	NXPH3_HUMAN	neurexophilin 3 precursor	86	III.				neuropeptide signaling pathway	extracellular region				pancreas(1)|skin(1)	2	all_cancers(4;7.45e-14)|Breast(4;1.08e-27)|all_epithelial(4;2.27e-17)					CCAACCGCCCGAACCACAGCC	0.627			NA											4	23					0	0	0.00024832	0	0
CA10	56934	broad.mit.edu	37	17	50008437	50008437	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:50008437T>A	uc002itw.3	-	3	1178	c.192A>T	c.(190-192)AAA>AAT	p.K64N	CA10_uc002itv.3_Missense_Mutation_p.K70N|CA10_uc002itx.3_Missense_Mutation_p.K64N|CA10_uc002ity.3_Missense_Mutation_p.K64N|CA10_uc002itz.2_Missense_Mutation_p.K64N	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	64					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GCGACTGCCGTTTCCCCACAG	0.478			NA											18	107					0	0	0.000958276	0	0
ANKFN1	162282	broad.mit.edu	37	17	54543847	54543847	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:54543847A>T	uc002iun.1	+	14	1732	c.1697A>T	c.(1696-1698)CAG>CTG	p.Q566L		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	566										large_intestine(1)|ovary(1)	2						AAATGGATGCAGATCTCAAAG	0.398			NA											8	37					0	0	0.00307968	0	0
BZRAP1	9256	broad.mit.edu	37	17	56400700	56400700	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:56400700C>A	uc002ivx.3	-	7	1934	c.1063G>T	c.(1063-1065)GAG>TAG	p.E355*	BZRAP1_uc010dcs.2_Nonsense_Mutation_p.E295*|BZRAP1_uc010wnt.1_Nonsense_Mutation_p.E355*	NM_004758	NP_004749	O95153	RIMB1_HUMAN	peripheral benzodiazepine receptor-associated	355						mitochondrion	benzodiazepine receptor binding			upper_aerodigestive_tract(2)|skin(1)	3	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GCTTCCTGCTCCAGGCTCTCG	0.607			NA											21	90					6.44725e-10	2.61569e-09	0.00229938	1	0
TMEM49	81671	broad.mit.edu	37	17	57917132	57917132	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:57917132G>C	uc002ixu.3	+	12	1354	c.1081G>C	c.(1081-1083)GAA>CAA	p.E361Q	TMEM49_uc010wog.1_Missense_Mutation_p.E169Q|TMEM49_uc010woh.1_Missense_Mutation_p.E305Q|TMEM49_uc010woi.1_Missense_Mutation_p.E264Q|TMEM49_uc010woj.1_Missense_Mutation_p.E227Q|TMEM49_uc002ixv.2_RNA|MIR21_hsa-mir-21|MI0000077_5'Flank	NM_030938	NP_112200	Q96GC9	VMP1_HUMAN	transmembrane protein 49	361	Cytoplasmic (Potential).				autophagy|cell adhesion	endoplasmic reticulum|ER-Golgi intermediate compartment membrane|integral to membrane|plasma membrane|vacuolar membrane					0	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;1.15e-09)|all cancers(12;1.15e-08)			TCTACAGGGAGAAAACTGGTT	0.368			NA											20	299					0	0	0.00229938	0	0
DNAI2	64446	broad.mit.edu	37	17	72278023	72278023	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:72278023C>G	uc002jkf.2	+	2	166	c.67C>G	c.(67-69)CGC>GGC	p.R23G	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	23					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						TTTCTCGGACCGCCAGGCCGA	0.617			NA							Kartagener_syndrome				11	34					0	0	0.00185496	0	0
FAM38B	63895	broad.mit.edu	37	18	10681738	10681738	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:10681738T>A	uc002kor.3	-	9	1371	c.1231A>T	c.(1231-1233)ATG>TTG	p.M411L	FAM38B_uc002koq.2_Missense_Mutation_p.M246L	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2454						integral to membrane	ion channel activity			ovary(1)	1						TGGGCACTCATTGTGAAAATA	0.378			NA											16	71					0	0	0.00074312	0	0
MC5R	4161	broad.mit.edu	37	18	13826290	13826290	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:13826290G>T	uc010xaf.1	+	1	526	c.526G>T	c.(526-528)GTC>TTC	p.V176F		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	176	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CTGCGGCATTGTCTTCATCCT	0.557			NA											68	203					1.77791e-30	9.02993e-30	0.00361006	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14787073	14787073	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:14787073G>T	uc010dlo.2	+	15	1888	c.1708G>T	c.(1708-1710)GAT>TAT	p.D570Y	ANKRD30B_uc010xak.1_RNA	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	570										ovary(1)|skin(1)	2						ACAAAAGGACGATGAAGAAAA	0.289			NA											12	47					4.3838e-07	1.58781e-06	0.00185496	1	0
ZNF521	25925	broad.mit.edu	37	18	22806665	22806665	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:22806665C>A	uc002kvk.2	-	4	1464	c.1217G>T	c.(1216-1218)AGC>ATC	p.S406I	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.S406I|ZNF521_uc002kvl.2_Missense_Mutation_p.S186I	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	406	C2H2-type 9; degenerate.				cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GTAAATACAGCTGTAGGTAAC	0.463			NA	T	PAX5	ALL								26	49					3.73988e-18	1.76664e-17	0.00106085	1	0
CDH2	1000	broad.mit.edu	37	18	25570215	25570215	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:25570215C>A	uc002kwg.2	-	10	1903	c.1444G>T	c.(1444-1446)GCA>TCA	p.A482S	CDH2_uc010xbn.1_Missense_Mutation_p.A451S	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	482	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						GACACGGTTGCAGTTGACTGA	0.448			NA											18	49					1.01871e-10	4.23471e-10	0.00121646	1	0
CDH2	1000	broad.mit.edu	37	18	25583076	25583076	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:25583076C>A	uc002kwg.2	-	7	1364	c.905G>T	c.(904-906)GGG>GTG	p.G302V	CDH2_uc010xbn.1_Missense_Mutation_p.G271V	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	302	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCTCAACATCCCATTGAGGGC	0.458			NA											21	41					0.000175454	0.000543667	0.00152264	1	0
DSC2	1824	broad.mit.edu	37	18	28651795	28651795	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:28651795C>G	uc002kwl.3	-	13	2355	c.1901G>C	c.(1900-1902)CGT>CCT	p.R634P	DSC2_uc002kwk.3_Missense_Mutation_p.R634P	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	634	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			ATAGGAAAGACGTGCTGCTGT	0.323			NA											12	34					0	0	0.00244969	0	0
DSG3	1830	broad.mit.edu	37	18	29039949	29039949	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:29039949C>A	uc002kws.2	+	6	768	c.659C>A	c.(658-660)ACT>AAT	p.T220N		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	220	Extracellular (Potential).|Cadherin 2.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAAGTCCGTACTTTGACCAAT	0.438			NA											10	16					1.08611e-07	3.99818e-07	0.000978159	1	0
C18orf34	374864	broad.mit.edu	37	18	30926184	30926184	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:30926184C>G	uc002kxn.2	-	8	791	c.649G>C	c.(649-651)GTG>CTG	p.V217L	C18orf34_uc010xbr.1_Missense_Mutation_p.V217L|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.V217L|C18orf34_uc002kxp.2_Missense_Mutation_p.V217L	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	217										ovary(1)	1						CCTTTCTGCACAGCCAATGGG	0.323			NA											24	56					0	0	0.00127121	0	0
ACAA2	10449	broad.mit.edu	37	18	47329179	47329179	+	Nonsense_Mutation	SNP	C	C	A	rs147007453	by1000genomes	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:47329179C>A	uc002ldw.3	-	2	458	c.61G>T	c.(61-63)GGA>TGA	p.G21*	ACAA2_uc002ldx.3_Nonsense_Mutation_p.G18*	NM_006111	NP_006102	P42765	THIM_HUMAN	acetyl-coenzyme A acyltransferase 2	21					anti-apoptosis|cholesterol biosynthetic process		acetyl-CoA C-acyltransferase activity|protein binding			ovary(1)	1						AGAAGGCCTCCGTAAGCTCCA	0.453			NA											21	50					7.41877e-09	2.89675e-08	0.00188189	1	0
SERPINB4	6318	broad.mit.edu	37	18	61328320	61328320	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:61328320C>A	uc002ljg.2	-	1	157	c.131G>T	c.(130-132)GGA>GTA	p.G44V	SERPINB3_uc002lji.2_Missense_Mutation_p.G44V|SERPINB3_uc010dqa.2_Missense_Mutation_p.G44V|SERPINB3_uc010dqb.2_Missense_Mutation_p.G44V|SERPINB3_uc010dqc.2_Missense_Mutation_p.G44V			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	44					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						GTCTTTGGCTCCTAAGAGGAC	0.438			NA											28	97					5.60225e-13	2.5145e-12	0.00178596	1	0
SERPINB10	5273	broad.mit.edu	37	18	61602259	61602259	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:61602259C>A	uc010xev.1	+	8	1067	c.977C>A	c.(976-978)TCT>TAT	p.S326Y	SERPINB10_uc010xew.1_Missense_Mutation_p.S326Y	NM_005024	NP_005015	P48595	SPB10_HUMAN	serine (or cysteine) proteinase inhibitor, clade	326						cytoplasm|nucleus	serine-type endopeptidase inhibitor activity			lung(1)|kidney(1)|skin(1)	3		Esophageal squamous(42;0.131)				TCAGGAATGTCTTCAGCAAGA	0.428			NA											16	32					6.31663e-08	2.36392e-07	0.00316338	1	0
PQLC1	80148	broad.mit.edu	37	18	77703343	77703343	+	Missense_Mutation	SNP	C	C	A	rs139297349		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr18:77703343C>A	uc002lnl.2	-	3	495	c.323G>T	c.(322-324)CGC>CTC	p.R108L	PQLC1_uc010dre.2_Missense_Mutation_p.R25L|PQLC1_uc002lnk.2_Missense_Mutation_p.R108L|PQLC1_uc010xfm.1_Missense_Mutation_p.R108L	NM_025078	NP_079354	Q8N2U9	PQLC1_HUMAN	PQ loop repeat containing 1 isoform 1	108						integral to membrane				large_intestine(1)|ovary(1)	2		Esophageal squamous(42;0.0212)|Melanoma(33;0.2)		OV - Ovarian serous cystadenocarcinoma(15;8.2e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0258)		AAAGGAGCGGCGCCTGGCGTT	0.587			NA											28	114					2.47511e-08	9.55391e-08	0.001512	1	0
ABCA7	10347	broad.mit.edu	37	19	1053825	1053825	+	Silent	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:1053825A>C	uc002lqw.3	+	25	3693	c.3462A>C	c.(3460-3462)ACA>ACC	p.T1154T	ABCA7_uc010dsb.1_Silent_p.T1016T	NM_019112	NP_061985	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A, member 7	1154					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			pancreas(7)|ovary(1)|central_nervous_system(1)	9		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCGGACACAGATATGGAGG	0.627			NA											8	49					0	0	0.000442599	0	0
PCSK4	54760	broad.mit.edu	37	19	1488005	1488005	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:1488005G>T	uc002ltb.1	-	4	536	c.474C>A	c.(472-474)GAC>GAA	p.D158E	PCSK4_uc002lta.2_5'UTR	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	158	Catalytic (By similarity).	Charge relay system (By similarity).			proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGATGCCATCGTCCAGCACAG	0.682			NA											15	62					4.14922e-12	1.83189e-11	0.00400662	1	0
ITGB1BP3	27231	broad.mit.edu	37	19	3941117	3941117	+	Missense_Mutation	SNP	C	C	A	rs142587749		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:3941117C>A	uc002lyz.3	+	7	734	c.444C>A	c.(442-444)CAC>CAA	p.H148Q	ITGB1BP3_uc010xia.1_Missense_Mutation_p.H153Q	NM_170678	NP_733778	Q9NPI5	NRK2_HUMAN	integrin beta 1 binding protein 3	148					pyridine nucleotide biosynthetic process		ATP binding|metal ion binding|protein binding|ribosylnicotinamide kinase activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00463)|STAD - Stomach adenocarcinoma(1328;0.18)		TCGATGGCCACGTGTGGCCCA	0.612			NA											5	36					2.0095e-06	6.9433e-06	0.00198382	1	0
MAP2K2	5605	broad.mit.edu	37	19	4110509	4110509	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:4110509T>A	uc002lzk.2	-	3	702	c.448A>T	c.(448-450)ATG>TTG	p.M150L		NM_030662	NP_109587	P36507	MP2K2_HUMAN	mitogen-activated protein kinase kinase 2	150	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|extracellular region	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACTCACCATGTGTTCCATG	0.627			NA							Cardiofaciocutaneous_syndrome				6	44					0	0	0.00198382	0	0
MUC16	94025	broad.mit.edu	37	19	9028337	9028337	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9028337G>T	uc002mkp.2	-	11	36659	c.36455C>A	c.(36454-36456)CCT>CAT	p.P12152H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12154	SEA 1.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGGTCTTCAGGGTCAGGGCG	0.572			NA											23	81					4.16121e-05	0.000133534	0.00278032	1	0
MUC16	94025	broad.mit.edu	37	19	9090346	9090346	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9090346G>T	uc002mkp.2	-	1	1673	c.1469C>A	c.(1468-1470)TCT>TAT	p.S490Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	490	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CTGCCTCCCAGAGGTGCTGCC	0.537			NA											15	54					2.32078e-09	9.19466e-09	0.00316338	1	0
OR7G2	390882	broad.mit.edu	37	19	9213468	9213468	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9213468G>A	uc010xkk.1	-	1	515	c.515C>T	c.(514-516)ACT>ATT	p.T172I		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CACAACACTAGTCAACAGAGA	0.522	Esophageal Squamous(67;143 1448 28637 40648)		NA											7	46					0	0	0.00448238	0	0
ZNF699	374879	broad.mit.edu	37	19	9407478	9407478	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:9407478C>A	uc002mlc.1	-	5	602	c.602G>T	c.(601-603)GGA>GTA	p.G201V		NM_198535	NP_940937	Q32M78	ZN699_HUMAN	zinc finger protein 699	201	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAAGGCCTTTCCACACTCATG	0.418			NA											24	99					8.24728e-16	3.8421e-15	0.00465635	1	0
DNASE2	1777	broad.mit.edu	37	19	12989306	12989306	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:12989306A>T	uc002mvn.1	-	5	745	c.599T>A	c.(598-600)GTG>GAG	p.V200E	DNASE2_uc010xmr.1_Missense_Mutation_p.V145E	NM_001375	NP_001366	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal precursor	200					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding				0						GCCCTTGACCACATTCTCCAA	0.552			NA						Direct_reversal_of_damage					8	26					0	0	0.00307968	0	0
SLC5A5	6528	broad.mit.edu	37	19	17986910	17986910	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:17986910C>A	uc002nhr.3	+	5	1040	c.693C>A	c.(691-693)CTC>CTA	p.L231L		NM_000453	NP_000444	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium iodide	231	Extracellular (Potential).				cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGATCAACCTCATGGAGTGAG	0.468	Melanoma(65;1008 1708 7910 46650)		NA											13	35					5.50884e-06	1.84676e-05	0.00136819	1	0
NCAN	1463	broad.mit.edu	37	19	19345853	19345853	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:19345853T>A	uc002nlz.2	+	10	3297	c.3198T>A	c.(3196-3198)AAT>AAA	p.N1066K	NCAN_uc010ecc.1_Missense_Mutation_p.N630K	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1066	EGF-like 2; calcium-binding (Potential).				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			ATGAGGTCAATGGCTTTGTCT	0.517			NA											5	45					0	0	0.000602214	0	0
ZNF681	148213	broad.mit.edu	37	19	23927743	23927743	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:23927743A>G	uc002nrk.3	-	4	751	c.609T>C	c.(607-609)TGT>TGC	p.C203C	ZNF681_uc002nrl.3_Silent_p.C134C|ZNF681_uc002nrj.3_Silent_p.C134C	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	203	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				AGGCTTTTCCACAGTCTTCAC	0.294			NA											7	18					0	0	0.00448238	0	0
ZNF536	9745	broad.mit.edu	37	19	30934603	30934603	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:30934603A>T	uc002nsu.1	+	2	272	c.134A>T	c.(133-135)CAT>CTT	p.H45L	ZNF536_uc010edd.1_Missense_Mutation_p.H45L	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CAGCTCAGCCATGCCTTCCCC	0.682			NA											9	58					0	0	0.000442599	0	0
ZNF536	9745	broad.mit.edu	37	19	31039599	31039599	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:31039599C>A	uc002nsu.1	+	4	3211	c.3073C>A	c.(3073-3075)CTG>ATG	p.L1025M	ZNF536_uc010edd.1_Missense_Mutation_p.L1025M	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1025					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GGCCAACCACCTGGGCAAAGC	0.557			NA											7	49					1.12685e-05	3.70408e-05	0.00448238	1	0
TSHZ3	57616	broad.mit.edu	37	19	31770099	31770099	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:31770099G>T	uc002nsy.3	-	2	665	c.600C>A	c.(598-600)AGC>AGA	p.S200R		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	200					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					AGAGCTTGCTGCTCTGCCGGT	0.627			NA											9	34					1.08611e-07	3.99818e-07	0.000978159	1	0
ZFP30	22835	broad.mit.edu	37	19	38126323	38126323	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:38126323C>A	uc002ogv.1	-	6	1635	c.1119G>T	c.(1117-1119)CAG>CAT	p.Q373H	ZFP30_uc002ogw.1_Missense_Mutation_p.Q373H|ZFP30_uc002ogx.1_Missense_Mutation_p.Q373H|ZFP30_uc010xtt.1_Missense_Mutation_p.Q372H	NM_014898	NP_055713	Q9Y2G7	ZFP30_HUMAN	zinc finger protein 30 homolog	373	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGTATTCTCTGATGGAGAG	0.403			NA											21	66					5.26018e-13	2.36883e-12	0.00188189	1	0
MAP4K1	11184	broad.mit.edu	37	19	39103262	39103262	+	Silent	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:39103262C>G	uc002oix.1	-	9	762	c.654G>C	c.(652-654)GTG>GTC	p.V218V	MAP4K1_uc002oiy.1_Silent_p.V218V|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	218	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGAGAGGGTGCACATCAAAGA	0.622			NA											6	24					0	0	0.00116845	0	0
PSG7	5676	broad.mit.edu	37	19	43430685	43430685	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:43430685G>T	uc002ovl.3	-	5	995	c.893C>A	c.(892-894)CCC>CAC	p.P298H	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_RNA|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Intron|PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG7_uc010xwl.1_Missense_Mutation_p.P176H	NM_002783	NP_002774	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7	298	Ig-like C2-type 2.				female pregnancy	extracellular region					0		Prostate(69;0.00682)				CGTGACACTGGGTAGAATGAG	0.502			NA											41	188					1.41504e-22	6.95168e-22	0.00285205	1	0
PSG4	5672	broad.mit.edu	37	19	43708326	43708326	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:43708326C>A	uc002ovy.2	-	2	244	c.142G>T	c.(142-144)GGG>TGG	p.G48W	PSG4_uc002owa.2_RNA|PSG4_uc002owb.2_Missense_Mutation_p.G48W|PSG4_uc002ovz.2_Missense_Mutation_p.G48W	NM_002780	NP_002771	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4 isoform	48	Ig-like V-type.				defense response|female pregnancy	extracellular region				ovary(1)	1		Prostate(69;0.00682)				ACATCCTTCCCCTCAGAAACT	0.463			NA											32	178					1.71298e-08	6.6501e-08	0.00375469	1	0
TEX101	83639	broad.mit.edu	37	19	43920616	43920616	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:43920616G>C	uc010xwo.1	+	4	495	c.300G>C	c.(298-300)CTG>CTC	p.L100L	TEX101_uc002owk.2_Silent_p.L118L	NM_001130011	NP_001123483	Q9BY14	TX101_HUMAN	testis expressed 101 isoform 2	100						anchored to membrane|plasma membrane				ovary(1)	1		Prostate(69;0.0199)				CTCCCGGCCTGATCGTGACCT	0.527			NA											28	143					0	0	0.00178596	0	0
SLC8A2	6543	broad.mit.edu	37	19	47935674	47935674	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:47935674G>C	uc002pgx.2	-	9	2417	c.2139C>G	c.(2137-2139)TCC>TCG	p.S713S	SLC8A2_uc010xyq.1_Silent_p.S469S|SLC8A2_uc010xyr.1_Silent_p.S176S|SLC8A2_uc010ele.2_Silent_p.S713S	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	713	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		GCTCCTCCCGGGACCCGTCCT	0.622			NA											6	35					0	0	0.00198382	0	0
KLK2	3817	broad.mit.edu	37	19	51381809	51381809	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:51381809C>A	uc002ptv.2	+	5	821	c.780C>A	c.(778-780)AAC>AAA	p.N260K	KLK2_uc002ptu.2_3'UTR|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Missense_Mutation_p.N243K|KLK2_uc010ycm.1_Missense_Mutation_p.N158K|KLK2_uc010eoh.2_Missense_Mutation_p.N158K	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	260					proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		TCGCAGCCAACCCCTGAGTGC	0.557			NA	T	ETV4	prostate								17	71					1.33834e-09	5.38123e-09	0.000958276	1	0
SIGLEC8	27181	broad.mit.edu	37	19	51955805	51955805	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:51955805C>A	uc002pwt.2	-	7	1395	c.1328G>T	c.(1327-1329)GGA>GTA	p.G443V	SIGLEC8_uc010yda.1_Missense_Mutation_p.G334V|SIGLEC8_uc002pwu.2_Intron|SIGLEC8_uc010eox.2_Missense_Mutation_p.G350V	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	443	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATGGAGCTCTCCTTCCTCCCC	0.567			NA											12	33					5.50884e-06	1.84676e-05	0.00136819	1	0
ZNF534	147658	broad.mit.edu	37	19	52937229	52937229	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:52937229G>A	uc002pzk.2	+	2	98	c.37G>A	c.(37-39)GTG>ATG	p.V13M	ZNF534_uc002pzj.1_Missense_Mutation_p.V13M|ZNF534_uc010epo.1_Missense_Mutation_p.V13M|ZNF534_uc002pzl.2_Missense_Mutation_p.V13M	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTCAGCGATGTGGCCATAGA	0.443			NA											14	59					0	0	0.00244969	0	0
BIRC8	112401	broad.mit.edu	37	19	53793483	53793483	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:53793483A>T	uc002qbk.2	-	1	1393	c.145T>A	c.(145-147)TGG>AGG	p.W49R		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	49	BIR.				apoptosis		zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		TTGGGCTTCCAGTTGGCTAGC	0.433			NA											11	45					0	0	0.000978159	0	0
NLRP12	91662	broad.mit.edu	37	19	54313761	54313761	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:54313761C>A	uc002qch.3	-	3	1372	c.1152G>T	c.(1150-1152)GCG>GCT	p.A384A	NLRP12_uc010eqw.2_5'Flank|NLRP12_uc002qci.3_Silent_p.A384A|NLRP12_uc002qcj.3_Silent_p.A384A|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Silent_p.A384A	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	384	NACHT.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		AGACTTGGCCCGCCTGCTCTG	0.562			NA											34	139					5.66738e-07	2.04177e-06	0.00128727	1	0
USP29	57663	broad.mit.edu	37	19	57640279	57640279	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:57640279A>T	uc002qny.2	+	4	592	c.236A>T	c.(235-237)AAC>ATC	p.N79I		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	79					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTGAAAAACAACGTGTTCTTG	0.333			NA											10	43					0	0	0.000442599	0	0
ZNF264	9422	broad.mit.edu	37	19	57724116	57724116	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:57724116A>T	uc002qob.2	+	4	2064	c.1651A>T	c.(1651-1653)AGC>TGC	p.S551C		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	551	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		CTTCAGTCGCAGCTCGTCCCT	0.458			NA											20	59					0	0	0.000958276	0	0
ZSCAN4	201516	broad.mit.edu	37	19	58187796	58187796	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:58187796G>C	uc002qpu.2	+	3	980	c.283G>C	c.(283-285)GGT>CGT	p.G95R		NM_152677	NP_689890	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	95	SCAN box.				telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTTATGATTGGTGGCCACTG	0.398			NA											15	79					0	0	0.000566183	0	0
ZNF135	7694	broad.mit.edu	37	19	58578565	58578566	+	Missense_Mutation	DNP	GA	GA	AG			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:58578565_58578566GA>AG	uc010yhq.1	+	5	845_846	c.749_750GA>AG	c.(748-750)GGA>GAG	p.G250E	ZNF135_uc002qre.2_Missense_Mutation_p.G238E|ZNF135_uc002qrd.1_Missense_Mutation_p.G196E|ZNF135_uc002qrf.2_Missense_Mutation_p.G196E|ZNF135_uc002qrg.2_Missense_Mutation_p.G208E|ZNF135_uc010yhr.1_Missense_Mutation_p.G59E	NM_003436	NP_003427	B4DHH9	B4DHH9_HUMAN	zinc finger protein 135 isoform 2	250					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		ACGCACACAGGAGAGAGACCTT	0.47			NA											19	115					0	0	6.4e-05	0	0
NOL10	79954	broad.mit.edu	37	2	10712241	10712241	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:10712241C>A	uc002raq.2	-	21	2148	c.2023G>T	c.(2023-2025)GGA>TGA	p.G675*	NOL10_uc010yje.1_Nonsense_Mutation_p.G649*|NOL10_uc010yjf.1_Nonsense_Mutation_p.G625*|NOL10_uc002rap.2_Nonsense_Mutation_p.G625*	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	675						nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		TTCAGGTGTCCGGCCGAACGA	0.478			NA											46	166					6.23363e-37	3.19001e-36	0.00361006	1	0
DDX1	1653	broad.mit.edu	37	2	15760365	15760365	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:15760365G>T	uc002rce.2	+	17	1528	c.1240G>T	c.(1240-1242)GAT>TAT	p.D414Y	DDX1_uc010yjq.1_Missense_Mutation_p.D322Y	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	414	Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		GCATTCTTTCGATGTAAAGAA	0.363			NA											24	93					3.73808e-20	1.79721e-19	0.000878237	1	0
NT5C1B	93034	broad.mit.edu	37	2	18765484	18765484	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:18765484G>C	uc002rcz.2	-	6	1045	c.941C>G	c.(940-942)TCC>TGC	p.S314C	NT5C1B_uc002rcy.2_Missense_Mutation_p.S314C|NT5C1B_uc010exr.2_Missense_Mutation_p.S256C|NT5C1B_uc010yju.1_Missense_Mutation_p.S254C|NT5C1B_uc002rda.2_Missense_Mutation_p.S254C|NT5C1B_uc010yjv.1_Missense_Mutation_p.S331C|NT5C1B_uc010yjw.1_Missense_Mutation_p.S297C|NT5C1B_uc010exs.2_Missense_Mutation_p.S316C|NT5C1B_uc002rdb.1_Missense_Mutation_p.S106C	NM_001002006	NP_001002006	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 1	314					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GAGCGCGCAGGATGAGAGAGC	0.537			NA											21	84					0	0	0.00278032	0	0
APOB	338	broad.mit.edu	37	2	21225982	21225982	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:21225982C>T	uc002red.2	-	29	12440	c.12312G>A	c.(12310-12312)CTG>CTA	p.L4104L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4104					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GATTTCTTCTCAGCTTTGAAG	0.488			NA											27	120					0	0	0.001512	0	0
SPTBN1	6711	broad.mit.edu	37	2	54858128	54858128	+	Nonsense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:54858128C>T	uc002rxu.2	+	16	3193	c.2944C>T	c.(2944-2946)CAG>TAG	p.Q982*	SPTBN1_uc002rxx.2_Nonsense_Mutation_p.Q969*	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	982	Spectrin 7.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			CGAGTCCACCCAGGACCTGGG	0.587			NA											6	23					0	0	0.00116845	0	0
C2orf86	51057	broad.mit.edu	37	2	63631262	63631262	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:63631262C>G	uc002sch.2	-	10	1802	c.1356G>C	c.(1354-1356)AAG>AAC	p.K452N	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.K293N|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.K260N|C2orf86_uc002sci.1_Missense_Mutation_p.K428N|C2orf86_uc010fcr.1_Missense_Mutation_p.K342N	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	452					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TACCTTCACCCTTCTGAGAAA	0.433			NA											15	72					0	0	0.00400662	0	0
C2orf78	388960	broad.mit.edu	37	2	74042529	74042529	+	Silent	SNP	C	C	A	rs143445466	by1000genomes	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:74042529C>A	uc002sjr.1	+	3	1300	c.1179C>A	c.(1177-1179)CCC>CCA	p.P393P		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	393										ovary(2)	2						TAGAAATCCCCGATATTCACC	0.448			NA											8	17					1.12685e-05	3.70408e-05	0.00448238	1	0
LRRTM4	80059	broad.mit.edu	37	2	77745779	77745779	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:77745779G>T	uc002snr.2	-	3	1631	c.1216C>A	c.(1216-1218)CCA>ACA	p.P406T	LRRTM4_uc002snq.2_Missense_Mutation_p.P406T|LRRTM4_uc002sns.2_Missense_Mutation_p.P406T|LRRTM4_uc002snt.2_Missense_Mutation_p.P407T	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	406	Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TGAAACCCTGGGGAAGGGCTT	0.498			NA											9	39					7.48243e-07	2.65322e-06	0.000442599	1	0
REG1A	5967	broad.mit.edu	37	2	79348783	79348783	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:79348783C>A	uc002snz.2	+	3	263	c.160C>A	c.(160-162)CGT>AGT	p.R54S	REG1A_uc010ffx.1_Missense_Mutation_p.R54S|REG1A_uc010ysd.1_Missense_Mutation_p.R54S	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	54	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TAATGAAGACCGTGAGACCTG	0.567			NA											22	101					1.96292e-10	8.08509e-10	0.00152264	1	0
REG1A	5967	broad.mit.edu	37	2	79350017	79350017	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:79350017G>T	uc002snz.2	+	5	475	c.372G>T	c.(370-372)TGG>TGT	p.W124C	REG1A_uc010ysd.1_Missense_Mutation_p.W124C	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	124	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						ACAAGTCCTGGGGCATTGGAG	0.552			NA											17	66					2.27731e-05	7.41359e-05	0.00188189	1	0
REG1A	5967	broad.mit.edu	37	2	79350037	79350037	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:79350037G>A	uc002snz.2	+	5	495	c.392G>A	c.(391-393)AGT>AAT	p.S131N	REG1A_uc010ysd.1_Missense_Mutation_p.S131N	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	131	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						GCCCCAAGCAGTGTTAATCCT	0.577			NA											12	61					0	0	0.000978159	0	0
SNRNP200	23020	broad.mit.edu	37	2	96952157	96952157	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:96952157T>C	uc002svu.2	-	29	3981	c.3895A>G	c.(3895-3897)ACC>GCC	p.T1299A	SNRNP200_uc002svt.2_5'Flank|SNRNP200_uc010yuj.1_5'Flank|SNRNP200_uc002svv.1_5'Flank|SNRNP200_uc002svw.1_Missense_Mutation_p.T371A	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	1299						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						AAAAGTTCGGTTGGAGGGGGG	0.507			NA											13	53					0	0	0.00185496	0	0
PDCL3	79031	broad.mit.edu	37	2	101192814	101192814	+	Splice_Site	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:101192814A>G	uc002tao.2	+	6	690	c.578_splice	c.e6-2	p.E193_splice		NM_024065	NP_076970	Q9H2J4	PDCL3_HUMAN	phosducin-like 3						apoptosis|interspecies interaction between organisms	cytoplasm	protein binding				0						TTTACCATATAGAGTTGGAAT	0.433			NA											14	69					0	0	0.00316338	0	0
RGPD3	653489	broad.mit.edu	37	2	107040375	107040375	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:107040375C>T	uc010ywi.1	-	20	4105	c.4048G>A	c.(4048-4050)GGT>AGT	p.G1350S		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1350	RanBD1 2.				intracellular transport		binding			ovary(1)	1						TTTTCCTCACCACTGGATACT	0.383			NA											22	261					0	0	0.00106085	0	0
INSIG2	51141	broad.mit.edu	37	2	118864760	118864760	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:118864760G>A	uc002tlk.2	+	5	837	c.631G>A	c.(631-633)GCA>ACA	p.A211T	INSIG2_uc010yye.1_Missense_Mutation_p.A103T|INSIG2_uc002tll.2_Intron	NM_016133	NP_057217	Q9Y5U4	INSI2_HUMAN	insulin induced protein 2	211					ER-nuclear sterol response pathway	SREBP-SCAP-Insig complex				ovary(1)|central_nervous_system(1)	2						TCGACAACTGGCAATGGTAAG	0.378			NA											8	106					0	0	0.00307968	0	0
POTEF	728378	broad.mit.edu	37	2	130832747	130832747	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:130832747G>T	uc010fmh.2	-	17	2698	c.2298C>A	c.(2296-2298)ACC>ACA	p.T766T		NM_001099771	NP_001093241	A5A3E0	POTEF_HUMAN	prostate, ovary, testis expressed protein on	766	Actin-like.					cell cortex	ATP binding			skin(3)|ovary(2)	5						GGTACTTCAGGGTCAGGATGC	0.592			NA											15	60					1.99824e-07	7.31603e-07	0.000566183	1	0
LRP1B	53353	broad.mit.edu	37	2	141200182	141200182	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:141200182G>T	uc002tvj.1	-	66	11277	c.10305C>A	c.(10303-10305)AGC>AGA	p.S3435R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3435	Extracellular (Potential).|LDL-receptor class A 24.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTGGAGAACAGCTGTTTTCAG	0.378	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			22	72					4.26978e-12	1.87898e-11	0.00332997	1	0
CYTIP	9595	broad.mit.edu	37	2	158300414	158300414	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:158300414C>A	uc002tzj.1	-	1	191	c.119G>T	c.(118-120)AGA>ATA	p.R40I	CYTIP_uc010zcl.1_Intron	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	40					regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						TTGAATCCTTCTATTATCGTC	0.502			NA											9	86					2.74318e-10	1.12645e-09	0.000442599	1	0
ACVR1C	130399	broad.mit.edu	37	2	158401076	158401076	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:158401076T>C	uc002tzk.3	-	5	1067	c.824A>G	c.(823-825)CAG>CGG	p.Q275R	ACVR1C_uc002tzl.3_Missense_Mutation_p.Q195R|ACVR1C_uc010fof.2_Missense_Mutation_p.Q118R|ACVR1C_uc010foe.2_Missense_Mutation_p.Q225R	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	275	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						TAAGGAGCCCTGTTCATGATA	0.383			NA											13	69					0	0	0.00136819	0	0
GCA	25801	broad.mit.edu	37	2	163215621	163215621	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:163215621C>G	uc002ucg.2	+	6	698	c.522C>G	c.(520-522)TTC>TTG	p.F174L	GCA_uc010zcu.1_Missense_Mutation_p.F155L	NM_012198	NP_036330	P28676	GRAN_HUMAN	grancalcin, EF-hand calcium binding protein	174	EF-hand 4.				cellular membrane fusion	cytoplasm|plasma membrane	calcium ion binding|protein homodimerization activity				0						GCAGAATTTTCTTTGATGATT	0.308			NA											14	160					0	0	0.000566183	0	0
KCNH7	90134	broad.mit.edu	37	2	163693067	163693067	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:163693067A>T	uc002uch.1	-	2	499	c.287T>A	c.(286-288)GTC>GAC	p.V96D	KCNH7_uc002uci.2_Missense_Mutation_p.V96D	NM_033272	NP_150375	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H,	96	Cytoplasmic (Potential).|PAC.				regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			ovary(3)|skin(2)	5					Ibutilide(DB00308)	ATAGTAGGTGACCTCCACTTT	0.418	GBM(196;1492 2208 17507 24132 45496)		NA											6	34					0	0	0.00198382	0	0
SCN3A	6328	broad.mit.edu	37	2	165947492	165947492	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:165947492G>T	uc002ucx.2	-	28	5663	c.5171C>A	c.(5170-5172)CCC>CAC	p.P1724H	SCN3A_uc010zcy.1_Missense_Mutation_p.P207H|SCN3A_uc002ucy.2_Missense_Mutation_p.P1675H|SCN3A_uc002ucz.2_Missense_Mutation_p.P1675H	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1724						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	GTCACAGTCGGGTGGTGCACT	0.458			NA											25	115					4.87955e-14	2.24227e-13	0.000878237	1	0
SCN2A	6326	broad.mit.edu	37	2	166179956	166179956	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:166179956C>A	uc002udc.2	+	12	2252	c.1962C>A	c.(1960-1962)GTC>GTA	p.V654V	SCN2A_uc002udd.2_Silent_p.V654V|SCN2A_uc002ude.2_Silent_p.V654V	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	654					myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ATGGTGTGGTCTCCCTGGTCG	0.582			NA											4	11					0.000602214	0.00178811	0.000602214	1	0
SCN7A	6332	broad.mit.edu	37	2	167262212	167262212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:167262212G>A	uc002udu.1	-	25	5054	c.4927C>T	c.(4927-4929)CGA>TGA	p.R1643*		NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	1643					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TTGTCATTTCGCCTCAAGCGG	0.368			NA											16	166					0	0	0.000566183	0	0
XIRP2	129446	broad.mit.edu	37	2	168099116	168099116	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:168099116C>T	uc002udx.2	+	8	1232	c.1214C>T	c.(1213-1215)TCA>TTA	p.S405L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.S230L|XIRP2_uc010fpq.2_Missense_Mutation_p.S183L|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	230					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAGCCATCATCAGTTGTGAGT	0.428			NA											24	95					0	0	0.00395357	0	0
HOXD11	3237	broad.mit.edu	37	2	176973687	176973688	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:176973687_176973688CC>AA	uc002uki.2	+	2	834_835	c.834_835CC>AA	c.(832-837)ATCCGC>ATAAGC	p.R279S	HOXD11_uc010fqx.2_RNA	NM_021192	NP_067015	P31277	HXD11_HUMAN	homeobox D11	279	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0521)|READ - Rectum adenocarcinoma(9;0.0678)		AGTACCAGATCCGCGAACTGGA	0.525			NA	T	NUP98	AML								10	65					0	0	6.4e-05	0	0
TTN	7273	broad.mit.edu	37	2	179416521	179416521	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179416521A>T	uc010zfg.1	-	284	83626	c.83402T>A	c.(83401-83403)ATC>AAC	p.I27801N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.I21496N|TTN_uc010zfi.1_Missense_Mutation_p.I21429N|TTN_uc010zfj.1_Missense_Mutation_p.I21304N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28728							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGCCAGAGGATGCTATTTCT	0.408			NA											13	127					0	0	0.00185496	0	0
TTN	7273	broad.mit.edu	37	2	179430521	179430521	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179430521G>A	uc010zfg.1	-	275	72858	c.72634C>T	c.(72634-72636)CCT>TCT	p.P24212S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P17907S|TTN_uc010zfi.1_Missense_Mutation_p.P17840S|TTN_uc010zfj.1_Missense_Mutation_p.P17715S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25139							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGGAAGGAGGTTCAGCAGCT	0.478			NA											36	131					0	0	0.00148497	0	0
TTN	7273	broad.mit.edu	37	2	179451991	179451991	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179451991A>G	uc010zfg.1	-	256	56467	c.56243T>C	c.(56242-56244)GTT>GCT	p.V18748A	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V12443A|TTN_uc010zfi.1_Missense_Mutation_p.V12376A|TTN_uc010zfj.1_Missense_Mutation_p.V12251A	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	19675							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGGGGTAACGGTCGACCA	0.493			NA											14	44					0	0	0.00185496	0	0
TTN	7273	broad.mit.edu	37	2	179546109	179546109	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179546109G>T	uc010zfg.1	-	134	29733	c.29509C>A	c.(29509-29511)CCC>ACC	p.P9837T	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6498T|TTN_uc010fre.1_Intron|TTN_uc002una.1_5'Flank|TTN_uc010frf.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10764							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTACCTTTGGGTGGTGGAGGT	0.363			NA											9	35					1.12685e-05	3.70408e-05	0.00448238	1	0
TTN	7273	broad.mit.edu	37	2	179644746	179644746	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:179644746C>A	uc010zfg.1	-	22	3934	c.3710G>T	c.(3709-3711)AGA>ATA	p.R1237I	TTN_uc010zfh.1_Missense_Mutation_p.R1191I|TTN_uc010zfi.1_Missense_Mutation_p.R1191I|TTN_uc010zfj.1_Missense_Mutation_p.R1191I|TTN_uc002unb.2_Missense_Mutation_p.R1237I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1237							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACATAAGTTCTGACCACTAC	0.269			NA											15	75					3.45872e-05	0.000112056	0.00400662	1	0
ZNF804A	91752	broad.mit.edu	37	2	185800553	185800553	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:185800553G>C	uc002uph.2	+	4	1024	c.430G>C	c.(430-432)GTG>CTG	p.V144L		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	144						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AACTGTTACTGTGAGAGAAAA	0.353			NA											19	76					0	0	0.00278032	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801970	185801970	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:185801970C>G	uc002uph.2	+	4	2441	c.1847C>G	c.(1846-1848)ACT>AGT	p.T616S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	616						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAATCAGAAACTCGCTGCAAA	0.343			NA											31	129					0	0	0.00283554	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801983	185801983	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:185801983G>T	uc002uph.2	+	4	2454	c.1860G>T	c.(1858-1860)ATG>ATT	p.M620I		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	620						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GCTGCAAAATGGAAGCAGAGA	0.338			NA											41	134					1.00776e-21	4.91508e-21	0.00361006	1	0
Unknown	0	broad.mit.edu	37	2	190788122	190788122	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:190788122G>T	uc002uro.2	+	1	204	c.61G>T	c.(61-63)GGG>TGG	p.G21W						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;												NA						TGTATTCATTGGGAATCTCAA	0.443			NA											22	81					7.92952e-12	3.46692e-11	0.00395357	1	0
UNC80	285175	broad.mit.edu	37	2	210650811	210650811	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:210650811C>A	uc010zjc.1	+	5	702	c.622C>A	c.(622-624)CTG>ATG	p.L208M	UNC80_uc002vdj.1_Missense_Mutation_p.L208M	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	208						integral to membrane					0						CACCTTCCGTCTGGCCAGTGG	0.498			NA											19	79					8.34094e-07	2.93453e-06	0.00121646	1	0
ERBB4	2066	broad.mit.edu	37	2	212530153	212530153	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:212530153C>A	uc002veg.1	-	15	1864	c.1766G>T	c.(1765-1767)TGT>TTT	p.C589F	ERBB4_uc002veh.1_Missense_Mutation_p.C589F|ERBB4_uc010zji.1_Missense_Mutation_p.C589F|ERBB4_uc010zjj.1_Missense_Mutation_p.C589F|ERBB4_uc010fut.1_Missense_Mutation_p.C589F	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	589	Extracellular (Potential).|Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTTTTCCACACAGTTTGGGCC	0.428			NA								TSP Lung(8;0.080)			5	49					0.00198382	0.00580117	0.00198382	1	0
ABCA12	26154	broad.mit.edu	37	2	215884272	215884272	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:215884272A>T	uc002vew.2	-	12	1756	c.1536T>A	c.(1534-1536)AAT>AAA	p.N512K	ABCA12_uc002vev.2_Missense_Mutation_p.N194K|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	512					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ACTGATCCATATTTAAATTAA	0.343	Ovarian(66;664 1488 5121 34295)		NA											18	75					0	0	0.00152264	0	0
COL4A4	1286	broad.mit.edu	37	2	227876937	227876937	+	Silent	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:227876937A>C	uc010zlt.1	-	44	4947	c.4293T>G	c.(4291-4293)CGT>CGG	p.R1431R		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1431	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TGTCACCTTTACGTCCGGGAG	0.537			NA											3	19					0	0	0.00024832	0	0
SP100	6672	broad.mit.edu	37	2	231371124	231371124	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:231371124A>T	uc002vqt.2	+	22	2118	c.1977A>T	c.(1975-1977)ATA>ATT	p.I659I	SP100_uc002vqs.2_Silent_p.I659I|SP100_uc002vqu.1_Silent_p.I659I|SP100_uc010fxp.1_5'UTR	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	659	SAND.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGCTAAGTATACGCTGCGGTG	0.448			NA											8	39					0	0	0.00307968	0	0
FAM113A	64773	broad.mit.edu	37	20	2819111	2819111	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr20:2819111G>A	uc002wgz.1	-	6	1105	c.608C>T	c.(607-609)GCA>GTA	p.A203V	FAM113A_uc002whb.1_Missense_Mutation_p.A54V|FAM113A_uc002wha.1_Missense_Mutation_p.A54V|FAM113A_uc010zqa.1_Missense_Mutation_p.A50V|FAM113A_uc002whc.1_Missense_Mutation_p.A152V|VPS16_uc002whe.2_5'Flank|VPS16_uc002whf.2_5'Flank|VPS16_uc002whd.2_5'Flank	NM_022760	NP_073597	Q9H1Q7	F113A_HUMAN	hypothetical protein LOC64773	203							hydrolase activity|protein binding			ovary(2)	2						CAGGGAGCCTGCCAGGGGCTG	0.572			NA											5	33					0	0	0.00198382	0	0
ASXL1	171023	broad.mit.edu	37	20	31024829	31024829	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr20:31024829G>T	uc002wxs.2	+	12	4740	c.4314G>T	c.(4312-4314)CAG>CAT	p.Q1438H	ASXL1_uc010geb.2_Missense_Mutation_p.Q1329H	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1438					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						GCATCAAGCAGGCATTTTATG	0.517			NA	F|N|Mis		MDS|CMML								10	68					1.08611e-07	3.99818e-07	0.000978159	1	0
PREX1	57580	broad.mit.edu	37	20	47268019	47268019	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr20:47268019T>C	uc002xtw.1	-	22	2593	c.2570A>G	c.(2569-2571)TAT>TGT	p.Y857C	PREX1_uc002xtv.1_Missense_Mutation_p.Y154C	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	857					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			CACATACTCATACACCACGCC	0.622			NA											5	37					0	0	0.000602214	0	0
KRTAP15-1	254950	broad.mit.edu	37	21	31812810	31812810	+	Nonsense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:31812810C>G	uc002yod.2	+	1	165	c.165C>G	c.(163-165)TAC>TAG	p.Y55*		NM_181623	NP_853654	Q3LI76	KR151_HUMAN	keratin associated protein 15-1	55						intermediate filament					0						AGGAGACCTACTGTGAGCCCA	0.502			NA											13	80					0	0	0.00185496	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253550	32253550	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:32253550A>G	uc002yov.2	-	1	325	c.294T>C	c.(292-294)ACT>ACC	p.T98T		NM_175858	NP_787054	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	98						keratin filament	structural molecule activity			pancreas(1)	1						GGCTGTAGGTAGTTGAGCAGG	0.567			NA											6	43					0	0	0.00116845	0	0
MRPS6	64968	broad.mit.edu	37	21	35497779	35497779	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:35497779G>T	uc002ytp.2	+	2	362	c.184G>T	c.(184-186)GGG>TGG	p.G62W		NM_032476	NP_115865	P82932	RT06_HUMAN	mitochondrial ribosomal protein S6	62					translation	mitochondrion|small ribosomal subunit	rRNA binding|structural constituent of ribosome			skin(1)	1						CAACAGAGGCGGGTAAGTTTC	0.433			NA											26	104					3.28513e-13	1.48435e-12	0.00395357	1	0
POTEH	23784	broad.mit.edu	37	22	16287493	16287493	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:16287493G>T	uc010gqp.2	-	1	445	c.393C>A	c.(391-393)CTC>CTA	p.L131L	POTEH_uc002zlg.1_5'Flank|POTEH_uc002zlh.1_5'Flank|POTEH_uc002zlj.1_Intron	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	131										skin(1)	1						TCTTGCTCCTGAGTGTCTTCA	0.617			NA											36	273					2.00842e-17	9.45427e-17	0.0025221	1	0
OR11H1	81061	broad.mit.edu	37	22	16449081	16449081	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:16449081C>A	uc011agd.1	-	1	724	c.724G>T	c.(724-726)GGT>TGT	p.G242C		NM_001005239	NP_001005239	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H,	242	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		GAAGGCATACCCAACATAGCT	0.408			NA											49	166					3.10996e-30	1.57362e-29	0.00361006	1	0
CCT8L2	150160	broad.mit.edu	37	22	17072290	17072290	+	Missense_Mutation	SNP	C	C	A	rs141686687		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:17072290C>A	uc002zlp.1	-	1	1411	c.1151G>T	c.(1150-1152)GGG>GTG	p.G384V		NM_014406	NP_055221	Q96SF2	TCPQM_HUMAN	T-complex protein 1	384					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			ovary(1)	1	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ACTCCGCAGCCCCTGGGTGGT	0.567			NA											18	29					5.35267e-07	1.93354e-06	0.000958276	1	0
ARVCF	421	broad.mit.edu	37	22	19960554	19960554	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:19960554G>A	uc002zqz.2	-	15	2715	c.2444C>T	c.(2443-2445)TCG>TTG	p.S815L	ARVCF_uc002zqy.2_Missense_Mutation_p.S331L	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	815	ARM 10.				cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					TTCGCGTACCGATTGGCTGTG	0.687			NA											5	17					0	0	0.00116845	0	0
MAPK1	5594	broad.mit.edu	37	22	22142565	22142565	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:22142565G>A	uc002zvn.2	-	6	1077	c.837C>T	c.(835-837)TTC>TTT	p.F279F	MAPK1_uc002zvo.2_Silent_p.F279F|MAPK1_uc010gtk.1_Intron	NM_002745	NP_002736	P28482	MK01_HUMAN	mitogen-activated protein kinase 1	279	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|epidermal growth factor receptor signaling pathway|ERK1 and ERK2 cascade|induction of apoptosis|innate immune response|insulin receptor signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleoplasm	ATP binding|DNA binding|MAP kinase activity|phosphatase binding|RNA polymerase II carboxy-terminal domain kinase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3	Colorectal(54;0.105)	all_lung(157;3.89e-05)		READ - Rectum adenocarcinoma(21;0.0689)	Arsenic trioxide(DB01169)	CAGCATTTGGGAACAGCCTGT	0.363			NA											13	63					0	0	0.00400662	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30722752	30722752	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:30722752G>C	uc011akt.1	-	1	143	c.119C>G	c.(118-120)TCT>TGT	p.S40C	TBC1D10A_uc010gvu.2_Missense_Mutation_p.S40C|TBC1D10A_uc003ahk.3_Missense_Mutation_p.S40C	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	40						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						AGACCCGAGAGAGCTGAGTTC	0.597			NA											5	20					0	0	0.000602214	0	0
PNPLA5	150379	broad.mit.edu	37	22	44285300	44285300	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr22:44285300A>T	uc003beg.2	-	4	708	c.611T>A	c.(610-612)CTG>CAG	p.L204Q	PNPLA5_uc011aqc.1_Missense_Mutation_p.L64Q|PNPLA5_uc003beh.2_Missense_Mutation_p.L90Q	NM_138814	NP_620169	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	204					lipid catabolic process		hydrolase activity				0		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CAGCTCATGCAGGTTGGGGGA	0.567			NA											15	74					0	0	0.000566183	0	0
FANCD2	2177	broad.mit.edu	37	3	10140527	10140527	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:10140527G>T	uc003buw.2	+	43	4387	c.4309G>T	c.(4309-4311)GGC>TGC	p.G1437C	FANCD2_uc003bux.1_Intron|FANCD2_uc003buy.1_Intron|FANCD2_uc010hcw.1_Intron|C3orf24_uc003buz.2_Intron	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	1437					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ACCAGAGTCTGGCACTGATGG	0.458			NA	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	FanconAnemia				14	50					3.27435e-08	1.2461e-07	0.00244969	1	0
ATP2B2	491	broad.mit.edu	37	3	10413663	10413663	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:10413663A>T	uc003bvt.2	-	12	1928	c.1489T>A	c.(1489-1491)TGC>AGC	p.C497S	ATP2B2_uc003bvv.2_Missense_Mutation_p.C452S|ATP2B2_uc003bvw.2_Missense_Mutation_p.C452S|ATP2B2_uc010hdo.2_Missense_Mutation_p.C202S	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	497	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						TTGTCTGAGCAGATGGCTGTG	0.562	Ovarian(125;1619 1709 15675 19819 38835)		NA											20	41					0	0	0.00188189	0	0
KCNH8	131096	broad.mit.edu	37	3	19389436	19389436	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:19389436G>T	uc003cbk.1	+	5	985	c.790G>T	c.(790-792)GTG>TTG	p.V264L	KCNH8_uc011awe.1_Missense_Mutation_p.V264L|KCNH8_uc010hex.1_5'UTR	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	264	Helical; Name=Segment S2; (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TGACATTGCAGTGGAGATTCT	0.403	NSCLC(124;1625 1765 8018 24930 42026)		NA											25	80					2.79863e-10	1.14574e-09	0.00465635	1	0
ARPP21	10777	broad.mit.edu	37	3	35835431	35835431	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:35835431G>T	uc003cgb.2	+	20	2684	c.2420G>T	c.(2419-2421)GGT>GTT	p.G807V	ARPP21_uc003cga.2_Missense_Mutation_p.G788V|ARPP21_uc011axy.1_Missense_Mutation_p.G808V|ARPP21_uc003cgf.2_Missense_Mutation_p.G643V|ARPP21_uc003cgg.2_Missense_Mutation_p.G330V	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	807						cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AGCAATGCTGGTTGGCAGGTC	0.498			NA											7	12					0.00198382	0.00580117	0.00198382	1	0
SEMA3G	56920	broad.mit.edu	37	3	52474509	52474509	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:52474509C>G	uc003dea.1	-	10	1027	c.1027G>C	c.(1027-1029)GTG>CTG	p.V343L		NM_020163	NP_064548	Q9NS98	SEM3G_HUMAN	semaphorin sem2 precursor	343	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		ATGTGGTACACACAGACGGCG	0.622			NA											2	3					0	0	6.4e-05	0	0
CCDC66	285331	broad.mit.edu	37	3	56627033	56627033	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:56627033G>C	uc003dhz.2	+	8	1059	c.972G>C	c.(970-972)GTG>GTC	p.V324V	CCDC66_uc003dhy.2_5'UTR|CCDC66_uc003dhu.2_Silent_p.V290V|CCDC66_uc003dhx.2_RNA	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	324										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TCAGTGCTGTGAAACAAGAAC	0.338			NA											16	118					0	0	0.000958276	0	0
SUCLG2	8801	broad.mit.edu	37	3	67546341	67546341	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:67546341C>A	uc003dna.3	-	9	971	c.943G>T	c.(943-945)GCT>TCT	p.A315S	SUCLG2_uc010hob.2_Intron	NM_003848	NP_003839	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming beta subunit	315					succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|skin(1)	2		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	TCACAAGTAGCCATGGCGAGC	0.438			NA											10	21					3.07112e-06	1.05307e-05	0.000978159	1	0
GPR27	2850	broad.mit.edu	37	3	71804195	71804195	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:71804195G>T	uc011bge.1	+	1	995	c.995G>T	c.(994-996)GGC>GTC	p.G332V	EIF4E3_uc003dox.2_5'Flank|EIF4E3_uc011bgd.1_5'Flank|EIF4E3_uc010hoc.2_5'Flank	NM_018971	NP_061844	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	332	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		GCGCAGGCCGGCATCAACCCC	0.706			NA											4	8					0.00024832	0.000757292	0.00024832	1	0
PDZRN3	23024	broad.mit.edu	37	3	73433092	73433092	+	Silent	SNP	C	C	G	rs141774740		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:73433092C>G	uc003dpl.1	-	10	2721	c.2625G>C	c.(2623-2625)GCG>GCC	p.A875A	PDZRN3_uc011bgh.1_Silent_p.A532A|PDZRN3_uc010hoe.1_Silent_p.A573A|PDZRN3_uc011bgf.1_Silent_p.A592A|PDZRN3_uc011bgg.1_Silent_p.A595A	NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	875							ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GCTGGGCGTGCGCCGGGATGT	0.652			NA											6	30					0	0	0.00116845	0	0
CNTN3	5067	broad.mit.edu	37	3	74347277	74347277	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:74347277C>A	uc003dpm.1	-	17	2312	c.2232G>T	c.(2230-2232)GGG>GGT	p.G744G		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	744	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AGGTGGTAACCCCAAGAGGGC	0.453			NA											11	44					0.000978159	0.00289167	0.000978159	1	0
CADM2	253559	broad.mit.edu	37	3	86010741	86010741	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:86010741G>T	uc003dqj.2	+	7	1513	c.887G>T	c.(886-888)TGT>TTT	p.C296F	CADM2_uc003dqk.2_Missense_Mutation_p.C305F|CADM2_uc003dql.2_Missense_Mutation_p.C298F	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	296	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		ACATATCGATGTGAAGCCACA	0.413			NA											12	91					2.27111e-07	8.27027e-07	0.00136819	1	0
DPPA4	55211	broad.mit.edu	37	3	109050872	109050872	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:109050872C>A	uc003dxq.3	-	3	240	c.185G>T	c.(184-186)TGC>TTC	p.C62F	DPPA4_uc011bho.1_Missense_Mutation_p.C62F|DPPA4_uc011bhp.1_Missense_Mutation_p.C62F	NM_018189	NP_060659	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	62						nucleus	protein binding			upper_aerodigestive_tract(1)	1						TTTCTTAGGGCAGAGCACTGA	0.358			NA											10	97					3.86212e-05	0.000124232	0.000673444	1	0
WDR52	55779	broad.mit.edu	37	3	113082352	113082352	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:113082352C>A	uc003eae.1	-	20	2789	c.2743G>T	c.(2743-2745)GAA>TAA	p.E915*	WDR52_uc003ead.1_Nonsense_Mutation_p.E96*	NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	915										central_nervous_system(1)	1						TCAATGTCTTCTGGAATTGGC	0.363			NA											8	45					0.00307968	0.00896691	0.00307968	1	0
HCLS1	3059	broad.mit.edu	37	3	121350993	121350993	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:121350993C>A	uc003eeh.3	-	13	1404	c.1279G>T	c.(1279-1281)GTG>TTG	p.V427L	HCLS1_uc011bjj.1_Missense_Mutation_p.V390L	NM_005335	NP_005326	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1	427					erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity				0				GBM - Glioblastoma multiforme(114;0.0912)		CCCAGagccacagccccagcc	0.428			NA											9	48					0.000274275	0.00083082	0.00448238	1	0
SRPRB	58477	broad.mit.edu	37	3	133524720	133524720	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:133524720G>A	uc003epx.1	+	1	44	c.28G>A	c.(28-30)GCA>ACA	p.A10T		NM_021203	NP_067026	Q9Y5M8	SRPRB_HUMAN	signal recognition particle receptor, beta	10						endoplasmic reticulum membrane|integral to membrane	GTP binding|protein binding|receptor activity			ovary(1)	1						GCGCCGGGTGGCAGATGGCGG	0.682			NA											6	30					0	0	0.00198382	0	0
TRIM42	287015	broad.mit.edu	37	3	140409921	140409921	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:140409921G>A	uc003eto.1	+	4	2163	c.1972G>A	c.(1972-1974)GAC>AAC	p.D658N		NM_152616	NP_689829	Q8IWZ5	TRI42_HUMAN	tripartite motif-containing 42	658	Fibronectin type-III.					intracellular	zinc ion binding			lung(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|central_nervous_system(1)	7						ACAAATTCGGGACATAATGCA	0.443			NA											14	97					0	0	0.00185496	0	0
PLSCR2	57047	broad.mit.edu	37	3	146176237	146176237	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:146176237C>A	uc003evv.1	-	4	394	c.61G>T	c.(61-63)GAT>TAT	p.D21Y	PLSCR2_uc003evw.1_Missense_Mutation_p.D90Y	NM_020359	NP_065092	Q9NRY7	PLS2_HUMAN	phospholipid scramblase 2	21	Cytoplasmic (By similarity).				phospholipid scrambling	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity				0						AGTATCATATCTATCTATTAT	0.234			NA											4	14					1.23904e-05	4.04334e-05	0.000602214	1	0
AGTR1	185	broad.mit.edu	37	3	148459034	148459034	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:148459034C>A	uc003ewg.2	+	4	658	c.212C>A	c.(211-213)GCA>GAA	p.A71E	AGTR1_uc003ewh.2_Missense_Mutation_p.A71E|AGTR1_uc003ewi.2_Missense_Mutation_p.A71E|AGTR1_uc003ewj.2_Missense_Mutation_p.A71E|AGTR1_uc003ewk.2_Missense_Mutation_p.A71E	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	71	Helical; Name=2; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	TTGAATTTAGCACTGGCTGAC	0.408			NA											14	48					2.61681e-11	1.11877e-10	0.00244969	1	0
FAM194A	131831	broad.mit.edu	37	3	150396332	150396332	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:150396332C>A	uc003eyg.2	-	10	1178	c.1121G>T	c.(1120-1122)CGC>CTC	p.R374L	FAM194A_uc003eyh.2_Missense_Mutation_p.R228L	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	hypothetical protein LOC131831	374										skin(2)|ovary(1)	3						TGTTTTTAAGCGCTTTGAATC	0.269			NA											11	32					6.40141e-05	0.00020349	0.000978159	1	0
GPR149	344758	broad.mit.edu	37	3	154145425	154145425	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:154145425G>T	uc003faa.2	-	2	1154	c.1054C>A	c.(1054-1056)CTG>ATG	p.L352M		NM_001038705	NP_001033794	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	352	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(6)	6			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			GTGGCCAGCAGGGTAAGTAGA	0.532			NA											6	23					5.9392e-07	2.12271e-06	0.00116845	1	0
RFC4	5984	broad.mit.edu	37	3	186510311	186510311	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr3:186510311C>T	uc003fqz.2	-	7	866	c.643G>A	c.(643-645)GCC>ACC	p.A215T	RFC4_uc011bsc.1_Missense_Mutation_p.A215T|RFC4_uc011bsd.1_Missense_Mutation_p.A215T	NM_002916	NP_002907	P35249	RFC4_HUMAN	replication factor C 4	215					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|large_intestine(1)	5	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TCCTTCTTGGCAATGTCTAGT	0.353			NA											30	111					0	0	0.00106085	0	0
CPZ	8532	broad.mit.edu	37	4	8607877	8607877	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:8607877A>G	uc003glm.2	+	5	997	c.871A>G	c.(871-873)ATG>GTG	p.M291V	CPZ_uc003gll.2_RNA|CPZ_uc003gln.2_Missense_Mutation_p.M154V|CPZ_uc003glo.2_Missense_Mutation_p.M280V|CPZ_uc003glp.2_RNA	NM_001014447	NP_001014447	Q66K79	CBPZ_HUMAN	carboxypeptidase Z isoform 1	291				M -> I (in Ref. 1; AAB58911).	proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)|pancreas(1)	3						GCTGCCCTCCATGAACCCTGA	0.617			NA											3	12					0	0	0.00024832	0	0
PI4K2B	55300	broad.mit.edu	37	4	25256887	25256887	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:25256887G>T	uc003grk.2	+	3	757	c.624G>T	c.(622-624)AAG>AAT	p.K208N	PI4K2B_uc011bxs.1_Missense_Mutation_p.K112N	NM_018323	NP_060793	Q8TCG2	P4K2B_HUMAN	phosphatidylinositol 4-kinase type 2 beta	208	PI3K/PI4K.					cytoplasm|membrane	1-phosphatidylinositol 4-kinase activity|ATP binding			ovary(2)|skin(2)	4		Breast(46;0.173)				CTAAAACAAAGGTAAGCCAGA	0.398			NA											12	26					0.000151284	0.000470934	0.00185496	1	0
TBC1D19	55296	broad.mit.edu	37	4	26638832	26638832	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:26638832G>T	uc003gsf.3	+	5	565	c.295_splice	c.e5-1	p.G99_splice	TBC1D19_uc010iew.2_Splice_Site_p.G99_splice|TBC1D19_uc011bxu.1_Splice_Site_p.G34_splice	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19							intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				TTATGTTTCAGGGAAGTTGGG	0.279			NA											17	35					2.35188e-11	1.0087e-10	0.00074312	1	0
PCDH7	5099	broad.mit.edu	37	4	30726066	30726066	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:30726066C>A	uc003gsk.1	+	1	4030	c.3022C>A	c.(3022-3024)CAT>AAT	p.H1008N	PCDH7_uc011bxw.1_Missense_Mutation_p.H961N|PCDH7_uc011bxx.1_Missense_Mutation_p.H1008N	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	1008	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TGTTCAGCTTCATCCCCAGTC	0.517			NA											11	29					5.50884e-06	1.84676e-05	0.00136819	1	0
COX7B2	170712	broad.mit.edu	37	4	46737207	46737207	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:46737207C>A	uc003gxf.2	-	3	183	c.3G>T	c.(1-3)ATG>ATT	p.M1I	COX7B2_uc010ige.2_RNA	NM_130902	NP_570972	Q8TF08	CX7B2_HUMAN	cytochrome c oxidase subunit VIIb2 precursor	1						integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity				0						AGGGAAACATCATGAAGGATT	0.403			NA											13	47					2.32078e-09	9.19466e-09	0.00316338	1	0
NIPAL1	152519	broad.mit.edu	37	4	48032142	48032142	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:48032142G>A	uc003gxw.2	+	3	385	c.319G>A	c.(319-321)GGT>AGT	p.G107S		NM_207330	NP_997213	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	107	Cytoplasmic (Potential).					integral to membrane					0						TTTAGGACAAGGTGGACATTC	0.343			NA											11	52					0	0	0.000978159	0	0
C4orf40	401137	broad.mit.edu	37	4	71024281	71024281	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:71024281C>A	uc003hfa.3	+	4	385	c.312C>A	c.(310-312)CTC>CTA	p.L104L	C4orf40_uc003hfb.3_Silent_p.L104L	NM_214711	NP_999876	Q6MZM9	CD040_HUMAN	hypothetical protein LOC401137 precursor	104						extracellular region					0						TTCCTCCTCTCCCTCCTAGGG	0.527			NA											33	125					9.04072e-19	4.30071e-18	0.00327116	1	0
MUC7	4589	broad.mit.edu	37	4	71347308	71347308	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:71347308G>C	uc011cat.1	+	4	1135	c.847G>C	c.(847-849)GCC>CCC	p.A283P	MUC7_uc011cau.1_Missense_Mutation_p.A283P|MUC7_uc003hfj.2_Missense_Mutation_p.A283P|uc011cav.1_Intron	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	283	6.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			GACCACAGCTGCCCCACCCAC	0.577			NA											43	142					0	0	0.0025221	0	0
PRKG2	5593	broad.mit.edu	37	4	82096055	82096055	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:82096055G>T	uc003hmh.2	-	2	534	c.520C>A	c.(520-522)CCT>ACT	p.P174T	PRKG2_uc011cch.1_Missense_Mutation_p.P174T	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	174	cGMP 1.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ATCTGCTGAGGATCCAGTCTT	0.363			NA											31	124					1.06801e-11	4.65447e-11	0.00178596	1	0
ARHGAP24	83478	broad.mit.edu	37	4	86491874	86491875	+	Splice_Site	DNP	GG	GG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:86491874_86491875GG>TT	uc003hpk.2	+	2	629	c.180_splice	c.e2+1	p.L60_splice	ARHGAP24_uc003hpi.1_Splice_Site_p.L60_splice|ARHGAP24_uc003hpj.2_Splice_Site_p.L60_splice	NM_001025616	NP_001020787	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24 isoform 1						angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding				0		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CCAAGCCCTTGGTGAGTAGGAG	0.46			NA											14	53					0	0	6.4e-05	0	0
UBE2D3	7323	broad.mit.edu	37	4	103730964	103730964	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:103730964G>A	uc003hwk.2	-	3	534	c.73C>T	c.(73-75)CCA>TCA	p.P25S	UBE2D3_uc003hwi.2_Missense_Mutation_p.P25S|UBE2D3_uc003hwj.2_RNA|UBE2D3_uc003hwl.2_Missense_Mutation_p.P25S|UBE2D3_uc011cet.1_Missense_Mutation_p.P25S|UBE2D3_uc011ceu.1_Missense_Mutation_p.P25S|UBE2D3_uc003hwo.2_Missense_Mutation_p.P25S|UBE2D3_uc003hwp.2_Missense_Mutation_p.P25S|UBE2D3_uc003hwq.2_Missense_Mutation_p.P27S|UBE2D3_uc003hwr.2_Missense_Mutation_p.P25S	NM_181887	NP_871616	P61077	UB2D3_HUMAN	ubiquitin-conjugating enzyme E2D 3 isoform 1	25					apoptosis|BMP signaling pathway|DNA repair|negative regulation of type I interferon production|proteasomal ubiquitin-dependent protein catabolic process|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein monoubiquitination|transforming growth factor beta receptor signaling pathway	endosome membrane|plasma membrane	ATP binding|protein binding|ubiquitin-protein ligase activity				0		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.13e-08)		TCCCCAACTGGACCTGCAGAA	0.363			NA											16	93					0	0	0.00400662	0	0
TACR3	6870	broad.mit.edu	37	4	104512718	104512718	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:104512718G>T	uc003hxe.1	-	4	1154	c.1011C>A	c.(1009-1011)GTC>GTA	p.V337V		NM_001059	NP_001050	P29371	NK3R_HUMAN	tachykinin receptor 3	337	Helical; Name=7; (Potential).					integral to plasma membrane	tachykinin receptor activity			ovary(3)|lung(2)|breast(1)|skin(1)	7		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TAGCCAGGTAGACCTGCTGGA	0.398			NA											16	94					6.72482e-11	2.8215e-10	0.00316338	1	0
ANK2	287	broad.mit.edu	37	4	114278909	114278909	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:114278909G>T	uc003ibe.3	+	38	9235	c.9135G>T	c.(9133-9135)TGG>TGT	p.W3045C	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_Missense_Mutation_p.W347C|ANK2_uc011cgb.1_Missense_Mutation_p.W3060C	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	3012					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CTGATTCTTGGAGTGAAATTC	0.413			NA											31	105					3.03874e-20	1.46619e-19	0.00327116	1	0
LARP1B	55132	broad.mit.edu	37	4	129043061	129043061	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:129043061G>T	uc003iga.2	+	11	1373	c.1242G>T	c.(1240-1242)TTG>TTT	p.L414F	LARP1B_uc003igc.2_5'UTR|LARP1B_uc003ifz.1_Missense_Mutation_p.L414F|LARP1B_uc003igb.1_Missense_Mutation_p.L129F	NM_018078	NP_060548	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family member 2	414							RNA binding				0						TTGATTTTTTGTTTGATGAAG	0.338			NA											10	46					1.76689e-08	6.83975e-08	0.000442599	1	0
PCDH18	54510	broad.mit.edu	37	4	138451383	138451383	+	Silent	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:138451383T>A	uc003ihe.3	-	1	2247	c.1860A>T	c.(1858-1860)ATA>ATT	p.I620I	PCDH18_uc003ihf.3_Silent_p.I613I|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Silent_p.I400I|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	620	Cadherin 6.|Extracellular (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					TACCTGCTACTATGGCGCAGC	0.448			NA											60	212					0	0	0.00361006	0	0
IL15	3600	broad.mit.edu	37	4	142643115	142643115	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:142643115G>T	uc003iis.2	+	5	518	c.149G>T	c.(148-150)TGG>TTG	p.W50L	IL15_uc003iit.2_Missense_Mutation_p.W50L|IL15_uc010iol.2_RNA|IL15_uc003iiu.2_RNA	NM_000585	NP_000576	P40933	IL15_HUMAN	interleukin 15 preproprotein	50					cell-cell signaling|immune response|positive regulation of interleukin-17 production	endosome|extracellular space|Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	cytokine activity|cytokine receptor binding|signal transducer activity				0	all_hematologic(180;0.158)					GAAGCCAACTGGGTGAATGTA	0.353	Pancreas(10;184 986 25902)		NA											16	102					2.4624e-09	9.72719e-09	0.00121646	1	0
DCHS2	54798	broad.mit.edu	37	4	155191131	155191131	+	Silent	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:155191131A>G	uc003inw.2	-	19	5133	c.5133T>C	c.(5131-5133)CCT>CCC	p.P1711P		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1711	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAATTGAGTCAGGAGCAAAAG	0.338			NA											18	94					0	0	0.00152264	0	0
NPY2R	4887	broad.mit.edu	37	4	156136118	156136118	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:156136118G>C	uc003ioq.2	+	2	1522	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q	NPY2R_uc003ior.2_Missense_Mutation_p.E343Q	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	343	Cytoplasmic (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				CTTCCGCTGTGAGCAGCGGTT	0.512			NA											6	88					0	0	0.00307968	0	0
FSTL5	56884	broad.mit.edu	37	4	162697220	162697220	+	Missense_Mutation	SNP	T	T	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:162697220T>G	uc003iqh.2	-	5	852	c.416A>C	c.(415-417)AAG>ACG	p.K139T	FSTL5_uc003iqi.2_Missense_Mutation_p.K138T|FSTL5_uc010iqv.2_Missense_Mutation_p.K138T	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	139						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AGTCTTGCACTTATCTCCTGT	0.254			NA											3	28					0	0	0.00024832	0	0
TKTL2	84076	broad.mit.edu	37	4	164393100	164393100	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:164393100A>T	uc003iqp.3	-	1	1948	c.1787T>A	c.(1786-1788)GTG>GAG	p.V596E		NM_032136	NP_115512	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	596						cytoplasm	metal ion binding|transketolase activity			ovary(2)|skin(2)|pancreas(1)	5	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ACGTTGAGGCACTCCTGACAC	0.463			NA											13	55					0	0	0.00244969	0	0
DDX60	55601	broad.mit.edu	37	4	169158497	169158497	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:169158497C>A	uc003irp.2	-	32	4643	c.4351G>T	c.(4351-4353)GTT>TTT	p.V1451F		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	1451							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		CTGACAAAAACAAGATTAGAA	0.353			NA											11	34					1.58986e-06	5.52161e-06	0.000673444	1	0
NEK1	4750	broad.mit.edu	37	4	170523765	170523765	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:170523765C>G	uc003isb.1	-	2	509	c.17G>C	c.(16-18)AGA>ACA	p.R6T	NEK1_uc003isc.1_Missense_Mutation_p.R6T|NEK1_uc003isd.1_Missense_Mutation_p.R6T|NEK1_uc003ise.1_Missense_Mutation_p.R6T|NEK1_uc003isf.1_Missense_Mutation_p.R6T	NM_012224	NP_036356	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	6	Protein kinase.				cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(3)|ovary(2)|large_intestine(1)	6		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CTTCTGTAGTCTAACATACTT	0.308			NA											13	83					0	0	0.00244969	0	0
ADAM29	11086	broad.mit.edu	37	4	175898063	175898063	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:175898063G>T	uc003iuc.2	+	5	2057	c.1387G>T	c.(1387-1389)GAT>TAT	p.D463Y	ADAM29_uc003iud.2_Missense_Mutation_p.D463Y|ADAM29_uc010irr.2_Missense_Mutation_p.D463Y|ADAM29_uc011cki.1_Missense_Mutation_p.D463Y	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	463	Disintegrin.|Extracellular (Potential).				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CAATGAATGTGATCTTCCAGA	0.448	Ovarian(140;1727 1835 21805 25838 41440)		NA											7	55					8.12818e-05	0.000254784	0.00198382	1	0
ACSL1	2180	broad.mit.edu	37	4	185678789	185678789	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:185678789C>A	uc003iww.2	-	20	2250	c.1956G>T	c.(1954-1956)CAG>CAT	p.Q652H	ACSL1_uc011ckm.1_Missense_Mutation_p.Q481H|ACSL1_uc003iwt.1_Missense_Mutation_p.Q652H|ACSL1_uc003iwu.1_Missense_Mutation_p.Q652H|ACSL1_uc011ckn.1_Missense_Mutation_p.Q618H|ACSL1_uc003iws.1_Missense_Mutation_p.Q212H	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	652	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AAGGTCATACCTGTTCAAATG	0.348			NA											55	174					1.14385e-22	5.63995e-22	0.00361006	1	0
TLR3	7098	broad.mit.edu	37	4	186998018	186998018	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:186998018T>C	uc003iyq.2	+	2	346	c.245T>C	c.(244-246)GTA>GCA	p.V82A		NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	82	LRR 2.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		AGCTTGGATGTAGGATTTAAC	0.418			NA											19	91					0	0	0.00121646	0	0
FAT1	2195	broad.mit.edu	37	4	187539651	187539651	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr4:187539651C>A	uc003izf.2	-	10	8277	c.8089G>T	c.(8089-8091)GAA>TAA	p.E2697*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2697	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						AGCTGCATTTCCGGTGGAAGG	0.393	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			17	152					5.3912e-06	1.83003e-05	0.00074312	1	0
SEMA5A	9037	broad.mit.edu	37	5	9202174	9202174	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:9202174G>A	uc003jek.2	-	9	1537	c.825C>T	c.(823-825)CGC>CGT	p.R275R		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	275	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						AGCAGTTCAGGCGAGCCTTCA	0.522			NA											22	45					0	0	0.00278032	0	0
MARCH11	441061	broad.mit.edu	37	5	16067856	16067856	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:16067856G>T	uc003jfo.2	-	4	1146	c.933C>A	c.(931-933)CGC>CGA	p.R311R	MARCH11_uc010itw.1_Silent_p.R67R	NM_001102562	NP_001096032	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	311						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding				0						CAGCTCGCCAGCGCTTAAACA	0.428			NA											10	47					6.40141e-05	0.00020349	0.000978159	1	0
CDH9	1007	broad.mit.edu	37	5	26881683	26881683	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:26881683A>T	uc003jgs.1	-	12	2101	c.1932T>A	c.(1930-1932)CCT>CCA	p.P644P	CDH9_uc011cnv.1_Silent_p.P237P	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	644	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						AAATTATCAGAGGTTCCTTTT	0.388	Melanoma(8;187 585 15745 40864 52829)		NA											11	113					0	0	0.000978159	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33616098	33616098	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:33616098C>A	uc003jia.1	-	15	2386	c.2223G>T	c.(2221-2223)CTG>CTT	p.L741L	ADAMTS12_uc010iuq.1_Silent_p.L656L	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	741	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TCCTGATGGCCAGGAAGTTTC	0.438			NA								HNSCC(64;0.19)			11	74					7.03913e-09	2.75648e-08	0.00136819	1	0
SKP2	6502	broad.mit.edu	37	5	36171762	36171762	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:36171762G>T	uc003jkc.1	+	7	1010	c.828G>T	c.(826-828)GTG>GTT	p.V276V	SKP2_uc011cou.1_Silent_p.V62V|SKP2_uc003jkd.2_Silent_p.V276V	NM_005983	NP_005974	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2 isoform 1	276	LRR 6.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			central_nervous_system(2)|ovary(1)|breast(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ATGTACAGGTGGCTGTTGCGC	0.458			NA											83	140					4.47867e-22	2.19228e-21	0.00361006	1	0
RANBP3L	202151	broad.mit.edu	37	5	36270074	36270074	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:36270074G>T	uc003jkh.2	-	3	662	c.169C>A	c.(169-171)CTG>ATG	p.L57M	RANBP3L_uc011cow.1_Missense_Mutation_p.L57M	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	57					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			GCTTCATACAGGGTGTCTTCT	0.328			NA											69	183					1.25089e-41	6.45019e-41	0.00361006	1	0
C7	730	broad.mit.edu	37	5	40947812	40947812	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:40947812C>T	uc003jmh.2	+	8	961	c.847C>T	c.(847-849)CTC>TTC	p.L283F	C7_uc011cpn.1_Intron	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	283	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GCTTTCCCACCTCCCCTCTCT	0.448			NA											18	31					0	0	0.00074312	0	0
C7	730	broad.mit.edu	37	5	40958249	40958249	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:40958249C>T	uc003jmh.2	+	11	1489	c.1375C>T	c.(1375-1377)CCT>TCT	p.P459S	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	459	EGF-like.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				TCATTGCCGGCCTTGTCAAAA	0.488			NA											15	58					0	0	0.00244969	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41004995	41004995	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:41004995G>T	uc003jmj.3	-	36	4382	c.3892C>A	c.(3892-3894)CAT>AAT	p.H1298N	HEATR7B2_uc003jmi.3_Missense_Mutation_p.H853N	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1298							binding			ovary(6)|central_nervous_system(2)	8						AGATTCCCATGCTTCCAAAGG	0.527			NA											7	25					0.000274275	0.00083082	0.00448238	1	0
ITGA2	3673	broad.mit.edu	37	5	52371050	52371050	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:52371050G>T	uc003joy.2	+	23	2885	c.2742_splice	c.e23-1	p.S914_splice	ITGA2_uc011cqa.1_Splice_Site|ITGA2_uc011cqb.1_Splice_Site|ITGA2_uc011cqc.1_Splice_Site_p.S838_splice|ITGA2_uc011cqd.1_Splice_Site|ITGA2_uc011cqe.1_Splice_Site	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor						axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TCTTTCTATAGTGAAAGCCAA	0.353			NA											18	43					2.35188e-11	1.0087e-10	0.00074312	1	0
SKIV2L2	23517	broad.mit.edu	37	5	54674315	54674315	+	Splice_Site	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:54674315G>T	uc003jpy.3	+	17	2249	c.1983_splice	c.e17+1	p.K661_splice	SKIV2L2_uc011cqi.1_Splice_Site_p.K560_splice	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2						maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TTTGGTAAAGGTATGTCATTG	0.274	Melanoma(2;92 134 23744 29976 33782)		NA											7	34					8.12818e-05	0.000254784	0.00198382	1	0
VCAN	1462	broad.mit.edu	37	5	82836404	82836404	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:82836404G>C	uc003kii.3	+	8	7938	c.7582G>C	c.(7582-7584)GAG>CAG	p.E2528Q	VCAN_uc003kij.3_Missense_Mutation_p.E1541Q|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.E1192Q	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2528	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGGGAATTCGAGGATTCCAC	0.408			NA											12	50					0	0	0.000978159	0	0
FBXL17	64839	broad.mit.edu	37	5	107559923	107559923	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:107559923C>A	uc011cvc.1	-	5	1920	c.1513G>T	c.(1513-1515)GAT>TAT	p.D505Y	FBXL17_uc003kon.3_Missense_Mutation_p.D107Y	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	505											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		ACTGACTGATCTGTCACCTAG	0.313			NA											16	28					2.32078e-09	9.19466e-09	0.00316338	1	0
CAMK4	814	broad.mit.edu	37	5	110814169	110814169	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:110814169C>A	uc011cvj.1	+	10	891	c.792C>A	c.(790-792)CCC>CCA	p.P264P	CAMK4_uc003kpf.2_Silent_p.P264P|CAMK4_uc010jbv.2_Silent_p.P67P	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	264	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		TTATCTCCCCCTGGTGGGATG	0.333			NA											30	69					2.85442e-18	1.35309e-17	0.00209593	1	0
YTHDC2	64848	broad.mit.edu	37	5	112849603	112849603	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:112849603C>G	uc003kqn.2	+	1	194	c.11C>G	c.(10-12)CCG>CGG	p.P4R	YTHDC2_uc010jce.1_Missense_Mutation_p.P4R|YTHDC2_uc010jcf.1_5'UTR	NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	4							ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		ATGTCCAGGCCGAGCAGCGTC	0.716			NA											5	8					0	0	0.00116845	0	0
CSNK1G3	1456	broad.mit.edu	37	5	122927092	122927092	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:122927092A>T	uc003ktm.2	+	10	1789	c.1070A>T	c.(1069-1071)CAA>CTA	p.Q357L	CSNK1G3_uc003ktl.2_Missense_Mutation_p.Q357L|CSNK1G3_uc003ktn.2_Missense_Mutation_p.Q357L|CSNK1G3_uc003kto.2_Missense_Mutation_p.Q357L|CSNK1G3_uc011cwr.1_Missense_Mutation_p.Q282L|CSNK1G3_uc011cws.1_Missense_Mutation_p.Q245L|CSNK1G3_uc010jda.2_Missense_Mutation_p.Q358L	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	357					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		GATAAGATGCAACAATCCAAA	0.383	Pancreas(187;2868 2964 4353 6297)		NA											7	32					0	0	0.00307968	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128958013	128958013	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:128958013C>A	uc003kvb.1	+	10	1724	c.1724C>A	c.(1723-1725)CCA>CAA	p.P575Q	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	575	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTTTTTGGGCCATTGGCTTCT	0.443			NA											10	35					5.50884e-06	1.84676e-05	0.00136819	1	0
SKP1	6500	broad.mit.edu	37	5	133509710	133509710	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:133509710G>A	uc003kzc.3	-	2	183	c.4C>T	c.(4-6)CCT>TCT	p.P2S	SKP1_uc003kzd.3_Missense_Mutation_p.P2S|SKP1_uc010jdv.2_Missense_Mutation_p.P2S	NM_170679	NP_733779	P63208	SKP1_HUMAN	S-phase kinase-associated protein 1 isoform b	2					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|G1/S transition of mitotic cell cycle|histone H2A monoubiquitination|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|viral reproduction	cytosol|nucleoplasm|SCF ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTAATTGAAGGCATCTAAAAA	0.338			NA											13	42					0	0	0.00136819	0	0
PCDHA4	56144	broad.mit.edu	37	5	140189029	140189029	+	Nonsense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:140189029C>T	uc003lhi.2	+	1	2358	c.2257C>T	c.(2257-2259)CAG>TAG	p.Q753*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Nonsense_Mutation_p.Q753*|PCDHA4_uc011daa.1_Nonsense_Mutation_p.Q753*	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	753	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATACTCGCAGCAGAGGAGGCC	0.667			NA											12	34					0	0	0.00136819	0	0
PCDHB18	54660	broad.mit.edu	37	5	140615563	140615563	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:140615563C>A	uc003ljc.1	+	1	1626	c.1278C>A	c.(1276-1278)GAC>GAA	p.D426E		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						CAGACAGAGACTCAGGCACCA	0.652			NA											35	88					5.91797e-21	2.87596e-20	0.0024448	1	0
PCDHGA3	56112	broad.mit.edu	37	5	140725926	140725926	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:140725926G>A	uc003ljm.1	+	1	2326	c.2326G>A	c.(2326-2328)GCG>ACG	p.A776T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Missense_Mutation_p.A536T|PCDHGA3_uc011dap.1_Missense_Mutation_p.A776T	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	776	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCAACTATGCGGACACGCT	0.547			NA											25	69					0	0	0.00127121	0	0
ABLIM3	22885	broad.mit.edu	37	5	148626046	148626046	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:148626046G>T	uc003lpy.2	+	17	1739	c.1488G>T	c.(1486-1488)GTG>GTT	p.V496V	ABLIM3_uc003lpz.1_Silent_p.V496V|ABLIM3_uc003lqa.1_Silent_p.V393V|ABLIM3_uc003lqb.2_Silent_p.V385V|ABLIM3_uc003lqc.1_Silent_p.V463V|ABLIM3_uc003lqd.1_Silent_p.V401V|ABLIM3_uc003lqf.2_Silent_p.V385V|ABLIM3_uc003lqe.1_Silent_p.V385V	NM_014945	NP_055760	O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	496					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			ovary(2)|skin(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTTGACAGTGCCCCGAGCCA	0.473			NA											11	22					6.40141e-05	0.00020349	0.000978159	1	0
SLC36A1	206358	broad.mit.edu	37	5	150858985	150858985	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr5:150858985G>T	uc003luc.2	+	10	1311	c.1094G>T	c.(1093-1095)CGA>CTA	p.R365L	GM2A_uc011dcs.1_Intron|SLC36A1_uc003lub.1_Missense_Mutation_p.R365L|SLC36A1_uc010jhw.1_Missense_Mutation_p.R365L	NM_078483	NP_510968	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 member 1	365	Cytoplasmic (Potential).				cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			skin(1)	1		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TTTGTGTCCCGAGCGCCCGAG	0.507	Melanoma(151;1534 1860 12947 32979 37872)		NA											9	40					1.58986e-06	5.52161e-06	0.000673444	1	0
DEK	7913	broad.mit.edu	37	6	18258558	18258558	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:18258558C>G	uc003ncr.1	-	3	417	c.224G>C	c.(223-225)AGA>ACA	p.R75T	DEK_uc011djf.1_Intron|DEK_uc011djg.1_Intron	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	75					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			AAATGGCTCTCTCTGTAAGGA	0.353			NA	T	NUP214	AML								12	93					0	0	0.00136819	0	0
TNXB	7148	broad.mit.edu	37	6	32036389	32036389	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:32036389G>A	uc003nzl.2	-	17	6200	c.5998C>T	c.(5998-6000)CCT>TCT	p.P2000S		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2082	Fibronectin type-III 13.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AGGGAGTCAGGGGTGGCATCT	0.632			NA											7	17					0	0	0.00448238	0	0
CRISP3	10321	broad.mit.edu	37	6	49696489	49696489	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:49696489C>A	uc003ozs.2	-	8	707	c.692G>T	c.(691-693)AGG>ATG	p.R231M		NM_006061	NP_006052	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3 precursor	231					innate immune response	proteinaceous extracellular matrix|specific granule				skin(2)	2	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GCAACTGTCCCTGACCAACTG	0.388			NA											30	89					1.7881e-09	7.16832e-09	0.001512	1	0
GSTA1	2938	broad.mit.edu	37	6	52657758	52657758	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:52657758G>T	uc003paz.2	-	6	554	c.442C>A	c.(442-444)CTT>ATT	p.L148I		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	148	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	TTGCCAACAAGGTAGTCTTGT	0.527			NA											28	73					7.01153e-11	2.93269e-10	0.00127121	1	0
BAI3	577	broad.mit.edu	37	6	69349230	69349230	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:69349230C>A	uc003pev.3	+	3	1111	c.663C>A	c.(661-663)CCC>CCA	p.P221P	BAI3_uc010kak.2_Silent_p.P221P	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	221	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TGGTGTTACCCCTGAATGAGC	0.522			NA											12	20					3.07112e-06	1.05307e-05	0.000978159	1	0
MYO6	4646	broad.mit.edu	37	6	76599836	76599837	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:76599836_76599837GG>TT	uc003pih.1	+	26	3000_3001	c.2721_2722GG>TT	c.(2719-2724)GAGGAA>GATTAA	p.907_908EE>D*	MYO6_uc003pig.1_Nonsense_Mutation_p.907_908EE>D*|MYO6_uc003pii.1_Nonsense_Mutation_p.907_908EE>D*	NM_004999	NP_004990	Q9UM54	MYO6_HUMAN	myosin VI	907_908	Potential.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			kidney(1)|pancreas(1)	2		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AAAGCTCAGAGGAACTCCTCAG	0.366			NA											21	67					0	0	6.4e-05	0	0
SFRS18	25957	broad.mit.edu	37	6	99854038	99854038	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:99854038C>G	uc003ppo.3	-	8	1099	c.871G>C	c.(871-873)GAT>CAT	p.D291H	SFRS18_uc003ppp.3_Missense_Mutation_p.D291H|SFRS18_uc011eag.1_Missense_Mutation_p.D291H	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	291						nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TCTTCCTCATCACTATCCTAT	0.373			NA											14	26					0	0	0.00244969	0	0
GRIK2	2898	broad.mit.edu	37	6	102503354	102503354	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:102503354G>T	uc003pqp.3	+	15	2710	c.2461G>T	c.(2461-2463)GGT>TGT	p.G821C	GRIK2_uc003pqo.3_Missense_Mutation_p.G821C|GRIK2_uc010kcw.2_Missense_Mutation_p.G821C	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	821	Helical; (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TCAGAATATTGGTGGCATCTT	0.468			NA											31	61					3.67414e-24	1.82491e-23	0.0024448	1	0
SMPDL3A	10924	broad.mit.edu	37	6	123122474	123122474	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:123122474C>A	uc003pzg.2	+	4	1012	c.491C>A	c.(490-492)ACC>AAC	p.T164N	SMPDL3A_uc003pzh.2_Missense_Mutation_p.T33N	NM_006714	NP_006705	Q92484	ASM3A_HUMAN	acid sphingomyelinase-like phosphodiesterase 3A	164					sphingomyelin catabolic process	extracellular space	hydrolase activity, acting on glycosyl bonds|protein binding|sphingomyelin phosphodiesterase activity				0				GBM - Glioblastoma multiforme(226;0.236)		CCTGTAGTCACCAGTAAAGTG	0.328			NA											38	97					2.84425e-11	1.21217e-10	0.00285205	1	0
PTPRK	5796	broad.mit.edu	37	6	128312532	128312532	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:128312532G>A	uc003qbk.2	-	20	3250	c.2883C>T	c.(2881-2883)CCC>CCT	p.P961P	PTPRK_uc003qbj.2_Silent_p.P962P|PTPRK_uc010kfc.2_Silent_p.P968P|PTPRK_uc011ebu.1_Silent_p.P984P	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	961	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TTTCATGAACGGGACCTACAA	0.338			NA											13	24					0	0	0.00185496	0	0
LAMA2	3908	broad.mit.edu	37	6	129636648	129636648	+	Silent	SNP	C	C	T	rs1063373		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:129636648C>T	uc003qbn.2	+	25	3688	c.3583C>T	c.(3583-3585)CTA>TTA	p.L1195L	LAMA2_uc003qbo.2_Silent_p.L1195L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1195	Laminin IV type A 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCAGACCATTCTACCCCTGGT	0.463			NA											19	46					0	0	0.00152264	0	0
TAAR9	134860	broad.mit.edu	37	6	132859864	132859864	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:132859864G>T	uc011eci.1	+	2	438	c.436G>T	c.(436-438)GTG>TTG	p.V146L		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	146	Cytoplasmic (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		CAAGTTTACTGTGTCAGTTTC	0.393	Colon(10;433 445 15992 45047 47213)		NA											14	34					9.31168e-06	3.09854e-05	0.00185496	1	0
ZDHHC14	79683	broad.mit.edu	37	6	158014053	158014053	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:158014053G>C	uc003qqt.2	+	3	937	c.440G>C	c.(439-441)CGC>CCC	p.R147P	ZDHHC14_uc003qqs.2_Missense_Mutation_p.R147P|ZDHHC14_uc010kjm.1_Missense_Mutation_p.R42P	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	147						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		GGGGGGTACCGCCCGCCTCCC	0.567			NA											16	38					0	0	0.00400662	0	0
LPA	4018	broad.mit.edu	37	6	160969685	160969685	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr6:160969685C>T	uc003qtl.2	-	32	5100	c.4980G>A	c.(4978-4980)CTG>CTA	p.L1660L		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4168	Kringle 37.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	AGTTCATTGTCAGGCCACTGG	0.478			NA											13	36					0	0	0.00244969	0	0
PDE1C	5137	broad.mit.edu	37	7	31867932	31867932	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:31867932G>T	uc003tcm.1	-	12	1728	c.1259C>A	c.(1258-1260)TCC>TAC	p.S420Y	PDE1C_uc003tcn.1_Missense_Mutation_p.S420Y|PDE1C_uc003tco.1_Missense_Mutation_p.S480Y|PDE1C_uc003tcr.2_Missense_Mutation_p.S420Y|PDE1C_uc003tcs.2_Missense_Mutation_p.S420Y	NM_005020	NP_005011	Q14123	PDE1C_HUMAN	phosphodiesterase 1C	420	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(3)|central_nervous_system(1)	4			GBM - Glioblastoma multiforme(11;0.216)			AACCATAGTGGACTTTCGGTC	0.468			NA											8	34					1.06961e-07	3.98085e-07	0.00307968	1	0
VPS41	27072	broad.mit.edu	37	7	38857421	38857421	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:38857421T>A	uc003tgy.2	-	7	472	c.446A>T	c.(445-447)AAG>ATG	p.K149M	VPS41_uc003tgz.2_Missense_Mutation_p.K124M|VPS41_uc010kxn.2_Missense_Mutation_p.K149M	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	149					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						ACTTACCTTCTTCCCTCCGGT	0.433			NA											21	60					0	0	0.00278032	0	0
CDC14C	168448	broad.mit.edu	37	7	48964526	48964526	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:48964526G>T	uc010kyv.1	+	1	370	c.258G>T	c.(256-258)AAG>AAT	p.K86N		NR_003595				SubName: Full=Putative uncharacterized protein MGC26484;												0						TGTTAAGGAAGAAAATTGTTC	0.378			NA											9	61					0.000219431	0.000672226	0.00244969	1	0
ZNF735	730291	broad.mit.edu	37	7	63680250	63680250	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:63680250G>C	uc011kdn.1	+	4	821	c.821G>C	c.(820-822)TGT>TCT	p.C274S		NM_001159524	NP_001152996	P0CB33	ZN735_HUMAN	zinc finger protein 735	274	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTGAAGAATGTGGCCAAGCC	0.453			NA											12	35					0	0	0.00136819	0	0
RABGEF1	27342	broad.mit.edu	37	7	66240365	66240365	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:66240365G>A	uc011kee.1	+	3	537	c.373G>A	c.(373-375)GTC>ATC	p.V125I	RABGEF1_uc003tvf.2_5'UTR|RABGEF1_uc003tvg.2_5'UTR|RABGEF1_uc010lag.2_Missense_Mutation_p.V111I|RABGEF1_uc003tvh.2_Missense_Mutation_p.V111I|RABGEF1_uc003tvi.2_5'UTR	NM_014504	NP_055319	Q9UJ41	RABX5_HUMAN	RAB guanine nucleotide exchange factor (GEF) 1	289					endocytosis|protein transport	early endosome|recycling endosome	DNA binding|protein binding|zinc ion binding			ovary(1)	1						ATCTTCCAGGGTCGGATCAAA	0.443			NA											13	50					0	0	0.00244969	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72657661	72657661	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:72657661C>A	uc003txs.1	-	13	2251	c.1323G>T	c.(1321-1323)AAG>AAT	p.K441N	FKBP6_uc003twz.2_Intron	NR_002164				RecName: Full=General transcription factor II-I repeat domain-containing protein 2B; AltName: Full=GTF2I repeat domain-containing protein 2B; AltName: Full=Transcription factor GTF2IRD2-beta;												0						ggaattcggtcttgagttccg	0			NA											19	69					1.36615e-20	6.61528e-20	0.00283554	1	0
SEMA3C	10512	broad.mit.edu	37	7	80427413	80427413	+	Nonsense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:80427413C>A	uc003uhj.2	-	11	1688	c.1126G>T	c.(1126-1128)GGA>TGA	p.G376*	SEMA3C_uc011kgw.1_Nonsense_Mutation_p.G394*|SEMA3C_uc011kgx.1_Nonsense_Mutation_p.G228*	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	376	Sema.				immune response|response to drug	membrane	receptor activity			ovary(1)	1						CTTACAGTTCCAGGGCGAGGA	0.383			NA											12	33					0.00316338	0.00919081	0.00316338	1	0
ABCB1	5243	broad.mit.edu	37	7	87175280	87175280	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:87175280C>G	uc003uiz.1	-	16	2204	c.1786G>C	c.(1786-1788)GAC>CAC	p.D596H	ABCB1_uc011khc.1_Missense_Mutation_p.D532H	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	596	ABC transporter 1.|Cytoplasmic (Potential).				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCGATGACGTCAGCATTACGA	0.393			NA											4	88					0	0	0.00024832	0	0
GTPBP10	85865	broad.mit.edu	37	7	90014350	90014350	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:90014350A>T	uc003ukm.1	+	10	1112	c.1046A>T	c.(1045-1047)CAG>CTG	p.Q349L	GTPBP10_uc003ukn.1_Missense_Mutation_p.Q270L|GTPBP10_uc003uko.1_Missense_Mutation_p.Q159L|CLDN12_uc003ukp.2_5'UTR|CLDN12_uc003ukq.2_5'UTR	NM_033107	NP_149098	A4D1E9	GTPBA_HUMAN	GTP-binding protein 10 isoform 2	349					ribosome biogenesis	chromosome|nucleolus	GTP binding|GTPase activity|magnesium ion binding				0						CAGGCCAACCAGGAAAATGAT	0.388			NA											26	121					0	0	0.000878237	0	0
SAMD9	54809	broad.mit.edu	37	7	92733058	92733058	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:92733058C>A	uc003umf.2	-	3	2609	c.2353G>T	c.(2353-2355)GCA>TCA	p.A785S	SAMD9_uc003umg.2_Missense_Mutation_p.A785S	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	785						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CGGTTCATTGCCCCATAGGTG	0.388			NA											28	130					3.99451e-17	1.87381e-16	0.00178596	1	0
MUC17	140453	broad.mit.edu	37	7	100679317	100679317	+	Silent	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:100679317C>G	uc003uxp.1	+	3	4673	c.4620C>G	c.(4618-4620)GTC>GTG	p.V1540V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1540	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|23.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CTCCTGCTGTCACCAGCACAC	0.478			NA											56	220					0	0	0.00361006	0	0
MUC17	140453	broad.mit.edu	37	7	100682907	100682907	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:100682907A>T	uc003uxp.1	+	3	8263	c.8210A>T	c.(8209-8211)GAA>GTA	p.E2737V	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2737	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|44.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAACTGCTGAAGGTACCAGC	0.502			NA											60	296					0	0	0.00361006	0	0
RELN	5649	broad.mit.edu	37	7	103290776	103290776	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:103290776C>A	uc003vca.2	-	16	2107	c.1947G>T	c.(1945-1947)AGG>AGT	p.R649S	RELN_uc010liz.2_Missense_Mutation_p.R649S	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	649					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCCAGCGAATCCTGGTGTTCC	0.423	NSCLC(146;835 1944 15585 22231 52158)		NA											20	51					1.50039e-11	6.49688e-11	0.00188189	1	0
MLL5	55904	broad.mit.edu	37	7	104719376	104719376	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:104719376G>T	uc003vcm.2	+	12	1748	c.1214G>T	c.(1213-1215)CGA>CTA	p.R405L	MLL5_uc010lja.1_Missense_Mutation_p.R259L|MLL5_uc010ljb.1_Missense_Mutation_p.R405L|MLL5_uc003vcl.2_Missense_Mutation_p.R405L|MLL5_uc010ljc.2_Missense_Mutation_p.R405L|MLL5_uc003vco.1_Intron|MLL5_uc010ljd.1_Missense_Mutation_p.R43L	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	405	SET.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AATGAGGCTCGATTCATCAGG	0.423			NA											22	70					5.35356e-11	2.25316e-10	0.00278032	1	0
LAMB1	3912	broad.mit.edu	37	7	107575913	107575913	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:107575913C>G	uc003vew.2	-	27	4470	c.4135G>C	c.(4135-4137)GAT>CAT	p.D1379H	LAMB1_uc003vev.2_Missense_Mutation_p.D1403H	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1379	Potential.|Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCCAGTTCATCAAGGAGGCGA	0.507			NA											20	162					0	0	0.00152264	0	0
LAMB1	3912	broad.mit.edu	37	7	107580657	107580657	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:107580657G>T	uc003vew.2	-	25	3873	c.3538C>A	c.(3538-3540)CAC>AAC	p.H1180N	LAMB1_uc003vev.2_Missense_Mutation_p.H1204N	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1180	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGCACTGGTGGCAGGGTGTG	0.577			NA											9	48					1.12685e-05	3.70408e-05	0.00448238	1	0
PNPLA8	50640	broad.mit.edu	37	7	108128275	108128275	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:108128275C>G	uc003vff.1	-	10	2213	c.1806G>C	c.(1804-1806)TGG>TGC	p.W602C	PNPLA8_uc003vfg.1_RNA|PNPLA8_uc003vfh.1_Missense_Mutation_p.W602C|PNPLA8_uc003vfi.1_Missense_Mutation_p.W502C|PNPLA8_uc003vfj.1_Missense_Mutation_p.W602C|PNPLA8_uc003vfk.1_Missense_Mutation_p.W502C	NM_015723	NP_056538	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	602	Patatin.				fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(2)	2						TAATGGCCTGCCACATTTTAT	0.388			NA											11	47					0	0	0.000978159	0	0
C7orf58	79974	broad.mit.edu	37	7	120935629	120935629	+	Missense_Mutation	SNP	C	C	T	rs147434701	byFrequency	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:120935629C>T	uc003vjq.3	+	23	3451	c.3004C>T	c.(3004-3006)CAT>TAT	p.H1002Y		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	1002						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ATCGCCATATCATGTCAGAGG	0.378			NA											23	103					0	0	0.000878237	0	0
POT1	25913	broad.mit.edu	37	7	124503463	124503463	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:124503463C>A	uc003vlm.2	-	8	1088	c.487G>T	c.(487-489)GAC>TAC	p.D163Y	POT1_uc011koe.1_RNA|POT1_uc003vlk.2_RNA|POT1_uc003vll.2_RNA|POT1_uc003vlo.2_Missense_Mutation_p.D32Y|POT1_uc003vln.2_RNA	NM_015450	NP_056265	Q9NUX5	POTE1_HUMAN	protection of telomeres 1 isoform 1	163					DNA duplex unwinding|negative regulation of telomere maintenance via telomerase|positive regulation of DNA strand elongation|positive regulation of helicase activity|positive regulation of telomerase activity|positive regulation of telomere maintenance via telomerase|telomere capping|telomere formation via telomerase|telomere maintenance via telomerase	nuclear telomere cap complex|nucleoplasm	DEAD/H-box RNA helicase binding|single-stranded telomeric DNA binding|telomerase inhibitor activity			central_nervous_system(1)	1						CAAGTCAGGTCAAAATACTGC	0.403	Esophageal Squamous(149;1032 1141 16047 36610 40540 42429 44687 51642)		NA											21	97					1.10513e-12	4.8952e-12	0.00229938	1	0
EXOC4	60412	broad.mit.edu	37	7	133160178	133160178	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:133160178G>A	uc003vrk.2	+	8	1314	c.1279G>A	c.(1279-1281)GCC>ACC	p.A427T	EXOC4_uc011kpo.1_Missense_Mutation_p.A326T|EXOC4_uc003vri.2_Missense_Mutation_p.A427T|EXOC4_uc003vrj.2_Missense_Mutation_p.A427T	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	427					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGAGTTTGCAGCCTTTTTTGC	0.378			NA											30	136					0	0	0.00375469	0	0
CALD1	800	broad.mit.edu	37	7	134613555	134613555	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:134613555G>A	uc003vrz.2	+	4	581	c.122G>A	c.(121-123)CGG>CAG	p.R41Q	CALD1_uc003vry.2_Missense_Mutation_p.R41Q|CALD1_uc003vsa.2_Missense_Mutation_p.R41Q|CALD1_uc003vsb.2_Missense_Mutation_p.R41Q|CALD1_uc010lmm.2_Missense_Mutation_p.R41Q|CALD1_uc011kpt.1_5'UTR|CALD1_uc003vsc.2_Missense_Mutation_p.R35Q|CALD1_uc003vsd.2_Missense_Mutation_p.R35Q|CALD1_uc011kpu.1_Missense_Mutation_p.R46Q|CALD1_uc011kpv.1_5'UTR	NM_033138	NP_149129	Q05682	CALD1_HUMAN	caldesmon 1 isoform 1	41	Poly-Arg.|Myosin and calmodulin-binding (By similarity).				cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding				0						GCCCGGGAACGGCGCCGCCGA	0.587			NA											6	26					0	0	0.00307968	0	0
TAS2R4	50832	broad.mit.edu	37	7	141478324	141478324	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:141478324C>T	uc003vwq.1	+	1	36	c.36C>T	c.(34-36)GCC>GCT	p.A12A		NM_016944	NP_058640	Q9NYW5	TA2R4_HUMAN	taste receptor T2R4	12	Helical; Name=1; (Potential).				sensory perception of taste	cilium membrane	taste receptor activity				0	Melanoma(164;0.0171)			BRCA - Breast invasive adenocarcinoma(188;0.196)		CTATTATTGCCTCAGTTATTT	0.353			NA											12	50					0	0	0.000978159	0	0
OR9A4	130075	broad.mit.edu	37	7	141619587	141619587	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:141619587G>C	uc003vwu.1	+	1	912	c.912G>C	c.(910-912)GGG>GGC	p.G304G		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					TTCGGGATGGGGTGAAACGCT	0.423			NA											12	57					0	0	0.00136819	0	0
OR6V1	346517	broad.mit.edu	37	7	142749748	142749748	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:142749748C>A	uc011ksv.1	+	1	311	c.311C>A	c.(310-312)TCC>TAC	p.S104Y		NM_001001667	NP_001001667	Q8N148	OR6V1_HUMAN	olfactory receptor, family 6, subfamily V,	104	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.059)					TTCCACTTTTCCCTGGGGTCC	0.562			NA											14	73					1.36491e-13	6.20874e-13	0.00185496	1	0
OR2A5	393046	broad.mit.edu	37	7	143748240	143748240	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:143748240G>T	uc011ktw.1	+	1	746	c.746G>T	c.(745-747)GGA>GTA	p.G249V		NM_012365	NP_036497	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A,	249	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Melanoma(164;0.0783)					TGCATGGTGGGACTCTTCTTT	0.587			NA											9	68					5.4927e-09	2.15716e-08	0.00448238	1	0
CDK5	1020	broad.mit.edu	37	7	150752397	150752397	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:150752397T>A	uc003wir.1	-	8	608	c.547A>T	c.(547-549)ATC>TTC	p.I183F	CDK5_uc003wis.1_Missense_Mutation_p.I151F	NM_004935	NP_004926	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5 isoform 1	183	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			lung(1)|central_nervous_system(1)	2		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CACATGTCGATGGACGTGGAG	0.582			NA											7	23					0	0	0.00448238	0	0
MLL3	58508	broad.mit.edu	37	7	151856020	151856020	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:151856020C>G	uc003wla.2	-	44	11817	c.11598G>C	c.(11596-11598)AAG>AAC	p.K3866N	MLL3_uc003wkz.2_Missense_Mutation_p.K2927N|MLL3_uc003wkx.2_5'Flank|MLL3_uc003wky.2_Missense_Mutation_p.K1375N	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3866					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTTTCCTTTTCTTTGAGCGAG	0.483	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								16	149					0	0	0.00316338	0	0
MLL3	58508	broad.mit.edu	37	7	151945133	151945133	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr7:151945133T>A	uc003wla.2	-	14	2605	c.2386A>T	c.(2386-2388)ATG>TTG	p.M796L		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	796					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTATGCAGCATGTCATGCGAA	0.448	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								27	561					0	0	0.001512	0	0
RP1L1	94137	broad.mit.edu	37	8	10467395	10467395	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:10467395C>T	uc003wtc.2	-	4	4442	c.4213G>A	c.(4213-4215)GTC>ATC	p.V1405I		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1405					intracellular signal transduction			p.V1405I(1)		ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		TGCCCGTGGACGCTTCCTTCT	0.562			NA											64	211					0	0	0.00361006	0	0
DLC1	10395	broad.mit.edu	37	8	12943362	12943362	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:12943362G>C	uc003wwm.2	-	18	4989	c.4545C>G	c.(4543-4545)TTC>TTG	p.F1515L	DLC1_uc003wwk.1_Missense_Mutation_p.F1078L|DLC1_uc003wwl.1_Missense_Mutation_p.F1112L|DLC1_uc011kxx.1_Missense_Mutation_p.F1004L	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	1515	START.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCTGGTTACTGAAGGAATCCC	0.433			NA											4	67					0	0	0.00024832	0	0
UNC5D	137970	broad.mit.edu	37	8	35608192	35608192	+	Nonsense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:35608192T>A	uc003xjr.1	+	13	2356	c.2028T>A	c.(2026-2028)TAT>TAA	p.Y676*	UNC5D_uc003xjs.1_Nonsense_Mutation_p.Y671*|UNC5D_uc003xju.1_Nonsense_Mutation_p.Y252*	NM_080872	NP_543148	Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D precursor	676	Cytoplasmic (Potential).				apoptosis|axon guidance	integral to membrane	receptor activity			upper_aerodigestive_tract(2)|ovary(2)|pancreas(1)|skin(1)	6				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGGGACCTATGCGCTCACTG	0.512			NA											13	78					0	0	0.00185496	0	0
SNTG1	54212	broad.mit.edu	37	8	51314850	51314850	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:51314850G>T	uc010lxy.1	+	5	479	c.108G>T	c.(106-108)TTG>TTT	p.L36F	SNTG1_uc003xqs.1_Missense_Mutation_p.L36F|SNTG1_uc010lxz.1_Missense_Mutation_p.L36F|SNTG1_uc011ldl.1_RNA	NM_018967	NP_061840	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	36					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			ovary(5)	5		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AAGACATTTTGATGATCCAGG	0.383			NA											25	121					6.32553e-13	2.82973e-12	0.00465635	1	0
C8orf45	157777	broad.mit.edu	37	8	67790844	67790844	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:67790844A>G	uc003xwz.3	+	6	688	c.517A>G	c.(517-519)ACA>GCA	p.T173A	C8orf45_uc003xwv.2_Missense_Mutation_p.T173A|C8orf45_uc011lev.1_Missense_Mutation_p.T173A|C8orf45_uc011lew.1_Missense_Mutation_p.T104A|C8orf45_uc011lex.1_5'UTR|C8orf45_uc003xwy.3_Missense_Mutation_p.T173A	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	173					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			GCCTGGTGCTACAGAATCTGC	0.318			NA											28	102					0	0	0.00178596	0	0
SULF1	23213	broad.mit.edu	37	8	70539471	70539471	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:70539471T>C	uc010lza.1	+	16	2594	c.1877T>C	c.(1876-1878)ATC>ACC	p.I626T	SULF1_uc003xyd.2_Missense_Mutation_p.I626T|SULF1_uc003xye.2_Missense_Mutation_p.I626T|SULF1_uc003xyf.2_Missense_Mutation_p.I626T|SULF1_uc003xyg.2_Missense_Mutation_p.I626T|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_5'Flank	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	626					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AATGACTCTATCCATTGTGAG	0.388			NA											4	32					0	0	0.00024832	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70667841	70667841	+	Missense_Mutation	SNP	A	A	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:70667841A>C	uc003xyl.2	-	4	1783	c.1076T>G	c.(1075-1077)TTT>TGT	p.F359C	SLCO5A1_uc010lzb.2_Missense_Mutation_p.F359C|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Missense_Mutation_p.F359C|SLCO5A1_uc010lzc.2_Missense_Mutation_p.F359C	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	359	Helical; Name=6; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TATCACAAGAAACATTGCAAT	0.343			NA											7	44					0	0	0.000673444	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765873	77765873	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:77765873G>T	uc003yav.2	+	10	6968	c.6581G>T	c.(6580-6582)AGG>ATG	p.R2194M	ZFHX4_uc003yau.1_Missense_Mutation_p.R2239M|ZFHX4_uc003yaw.1_Missense_Mutation_p.R2194M	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2194	Homeobox 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TACCAGCTTAGGGTTCTGCAA	0.398			NA								HNSCC(33;0.089)			17	20					3.41278e-10	1.39295e-09	0.000566183	1	0
RUNX1T1	862	broad.mit.edu	37	8	92998434	92998434	+	Silent	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:92998434G>T	uc003yfd.2	-	8	1281	c.1197C>A	c.(1195-1197)GCC>GCA	p.A399A	RUNX1T1_uc003yfc.1_Silent_p.A372A|RUNX1T1_uc003yfe.1_Silent_p.A362A|RUNX1T1_uc010mao.2_Silent_p.A372A|RUNX1T1_uc011lgi.1_Silent_p.A410A|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Silent_p.A362A	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	399					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTAAGTCCTCGGCGTCACTGT	0.512			NA											49	90					3.86236e-30	1.94703e-29	0.00361006	1	0
VPS13B	157680	broad.mit.edu	37	8	100148930	100148930	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:100148930G>T	uc003yiv.2	+	12	1712	c.1601G>T	c.(1600-1602)GGG>GTG	p.G534V	VPS13B_uc003yiw.2_Missense_Mutation_p.G534V|VPS13B_uc003yit.2_Missense_Mutation_p.G534V|VPS13B_uc003yiu.1_Missense_Mutation_p.G534V|VPS13B_uc003yix.1_Missense_Mutation_p.G5V	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	534					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CAACGGTTTGGGGCTTTTTAT	0.368	Colon(161;2205 2542 7338 31318)		NA											41	183					3.77016e-25	1.88648e-24	0.00321405	1	0
VPS13B	157680	broad.mit.edu	37	8	100182324	100182324	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:100182324C>T	uc003yiv.2	+	16	2377	c.2266C>T	c.(2266-2268)CCT>TCT	p.P756S	VPS13B_uc003yiw.2_Missense_Mutation_p.P756S|VPS13B_uc003yit.2_Missense_Mutation_p.P756S|VPS13B_uc003yiu.1_Missense_Mutation_p.P756S|VPS13B_uc003yix.1_Missense_Mutation_p.P227S	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	756					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTACTGCTTACCTGTACCAGT	0.393	Colon(161;2205 2542 7338 31318)		NA											8	103					0	0	0.000442599	0	0
KLHL38	340359	broad.mit.edu	37	8	124664033	124664033	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:124664033G>T	uc003yqs.1	-	1	1158	c.1134C>A	c.(1132-1134)AGC>AGA	p.S378R		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	378	Kelch 2.										0						TATGGGCAGTGCTTCTGTGGG	0.552			NA											6	34					8.12818e-05	0.000254784	0.00198382	1	0
PHF20L1	51105	broad.mit.edu	37	8	133837560	133837560	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr8:133837560A>T	uc003ytt.2	+	14	2013	c.1688A>T	c.(1687-1689)CAC>CTC	p.H563L	PHF20L1_uc003yts.2_3'UTR|PHF20L1_uc011lja.1_Missense_Mutation_p.H537L|PHF20L1_uc003ytu.1_RNA	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	563	Lys-rich.						nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			gacaaagaTCACTACAGACCA	0.209			NA											7	23					0	0	0.00198382	0	0
TEK	7010	broad.mit.edu	37	9	27185554	27185554	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:27185554C>A	uc003zqi.3	+	9	1696	c.1254C>A	c.(1252-1254)GAC>GAA	p.D418E	TEK_uc011lno.1_Missense_Mutation_p.D375E|TEK_uc011lnp.1_Missense_Mutation_p.D271E|TEK_uc003zqj.1_Missense_Mutation_p.D352E	NM_000459	NP_000450	Q02763	TIE2_HUMAN	TEK tyrosine kinase, endothelial precursor	418	Extracellular (Potential).|Ig-like C2-type 2.				angiogenesis|blood coagulation|cell-cell signaling|leukocyte migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase B signaling cascade|protein oligomerization|transmembrane receptor protein tyrosine kinase signaling pathway	apical plasma membrane|basolateral plasma membrane|cell surface|integral to plasma membrane|membrane raft|microvillus	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			ovary(3)|central_nervous_system(3)|breast(3)|lung(2)|kidney(1)	12		all_neural(11;7.57e-10)|Myeloproliferative disorder(762;0.0255)		Lung(218;4.08e-05)|LUSC - Lung squamous cell carcinoma(38;0.00027)		TCCCCCCTGACTCAGGAGTTT	0.428			NA											18	63					1.15919e-05	3.80112e-05	0.00121646	1	0
DDX58	23586	broad.mit.edu	37	9	32500928	32500928	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:32500928T>A	uc003zra.2	-	2	274	c.116A>T	c.(115-117)CAG>CTG	p.Q39L	DDX58_uc010mjj.2_RNA|DDX58_uc010mjk.1_Intron|DDX58_uc011lnr.1_5'UTR|DDX58_uc010mji.2_5'UTR	NM_014314	NP_055129	O95786	DDX58_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide	39	CARD 1.				detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			ovary(2)|liver(1)|pancreas(1)	4			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CTGAATATACTGCACCTCTTC	0.443			NA											17	72					0	0	0.000958276	0	0
TAF1L	138474	broad.mit.edu	37	9	32630111	32630112	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:32630111_32630112CA>AT	uc003zrg.1	-	1	5556_5557	c.5466_5467TG>AT	c.(5464-5469)GATGGG>GAATGG	p.1822_1823DG>EW		NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1822_1823					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTTCCGTGCCCATCCTTGTGTT	0.495			NA											6	31					0	0	6.4e-05	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745609	37745609	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:37745609C>A	uc004aag.1	+	16	3624	c.3580C>A	c.(3580-3582)CAG>AAG	p.Q1194K	FRMPD1_uc004aah.1_Missense_Mutation_p.Q1194K	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1194						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GCAAGGCTGCCAGGCTCAAGA	0.522			NA											7	61					5.18039e-06	1.7629e-05	0.00307968	1	0
TRPM6	140803	broad.mit.edu	37	9	77357520	77357520	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:77357520C>A	uc004ajl.1	-	33	5395	c.5157G>T	c.(5155-5157)ATG>ATT	p.M1719I	TRPM6_uc004ajk.1_Missense_Mutation_p.M1714I|TRPM6_uc010mpb.1_RNA|TRPM6_uc010mpc.1_Missense_Mutation_p.M670I|TRPM6_uc010mpd.1_Missense_Mutation_p.M552I|TRPM6_uc010mpe.1_Intron|TRPM6_uc004ajj.1_Missense_Mutation_p.M675I	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel,	1719	Cytoplasmic (Potential).				response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|stomach(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	8						GAGAAAGCCTCATTAAATTAT	0.373			NA											10	39					2.27111e-07	8.27027e-07	0.00136819	1	0
PSAT1	29968	broad.mit.edu	37	9	80916926	80916926	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:80916926G>T	uc004ala.2	+	3	246	c.178G>T	c.(178-180)GTG>TTG	p.V60L	PSAT1_uc004alb.2_Missense_Mutation_p.V60L	NM_058179	NP_478059	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1 isoform 1	60					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			ovary(1)	1					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	AGAGAATCTTGTGCGGGAATT	0.328	Colon(34;187 791 10662 18313 37609)		NA											15	34					6.31663e-08	2.36392e-07	0.00316338	1	0
FLJ46321	389763	broad.mit.edu	37	9	84605877	84605877	+	Silent	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:84605877T>A	uc004amn.2	+	4	539	c.492T>A	c.(490-492)TCT>TCA	p.S164S		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	164						integral to membrane					0						CTTCGGCTTCTGCGACTGAGT	0.572			NA											7	47					0	0	0.00198382	0	0
Unknown	0	broad.mit.edu	37	9	90746020	90746020	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:90746020C>A	uc011lti.1	-	4	1961	c.1932G>T	c.(1930-1932)CAG>CAT	p.Q644H						SubName: Full=cDNA FLJ59639;												NA						CTCCCAGCACCTGCTGAGTAC	0.537			NA											22	85					1.10923e-09	4.47335e-09	0.00278032	1	0
TEX10	54881	broad.mit.edu	37	9	103092397	103092397	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:103092397T>A	uc004bas.2	-	6	1520	c.1305A>T	c.(1303-1305)TTA>TTT	p.L435F	TEX10_uc011lvf.1_Missense_Mutation_p.L274F|TEX10_uc011lvg.1_Missense_Mutation_p.L438F|TEX10_uc011lvh.1_Missense_Mutation_p.L370F	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	435						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CAGACAGTGTTAAATTCAGTA	0.388			NA											39	133					0	0	0.00148497	0	0
CYLC2	1539	broad.mit.edu	37	9	105767379	105767379	+	Missense_Mutation	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:105767379G>A	uc004bbs.2	+	5	536	c.466G>A	c.(466-468)GAT>AAT	p.D156N		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	156	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				agaaaagctagatgcaaagaa	0.07			NA											5	28					0	0	0.000602214	0	0
OR13C4	138804	broad.mit.edu	37	9	107289036	107289037	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:107289036_107289037CC>AA	uc011lvn.1	-	1	454_455	c.454_455GG>TT	c.(454-456)GGT>TTT	p.G152F		NM_001001919	NP_001001919	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATTGATTCCACCAGAAAGCCAT	0.426			NA											18	99					0	0	6.4e-05	0	0
ABCA1	19	broad.mit.edu	37	9	107595033	107595033	+	Missense_Mutation	SNP	T	T	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:107595033T>C	uc004bcl.2	-	12	1644	c.1331A>G	c.(1330-1332)GAC>GGC	p.D444G		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	444	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTGGTCATTGTCCCTGCTGTC	0.418			NA											12	48					0	0	0.00316338	0	0
ASTN2	23245	broad.mit.edu	37	9	120053783	120053783	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:120053783C>A	uc004bjs.1	-	2	553	c.452G>T	c.(451-453)GGC>GTC	p.G151V	ASTN2_uc004bjr.1_Missense_Mutation_p.G151V|ASTN2_uc004bjt.1_Missense_Mutation_p.G151V	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	151	Extracellular (Potential).					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CGCTGCTGTGCCAGACATCTC	0.602			NA											5	29					0.000602214	0.00178811	0.000602214	1	0
TLR4	7099	broad.mit.edu	37	9	120470921	120470921	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:120470921C>T	uc004bjz.2	+	2	465	c.174C>T	c.(172-174)AAC>AAT	p.N58N	TLR4_uc004bka.2_Silent_p.N18N|TLR4_uc004bkb.2_Intron	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	58	LRR 1.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CAACCAAGAACCTGGACCTGA	0.443			NA											20	127					0	0	0.00152264	0	0
OR5C1	392391	broad.mit.edu	37	9	125552135	125552135	+	Silent	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:125552135C>A	uc011lzd.1	+	1	924	c.924C>A	c.(922-924)ACC>ACA	p.T308T		NM_001001923	NP_001001923	Q8NGR4	OR5C1_HUMAN	olfactory receptor, family 5, subfamily C,	308	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCAGGCAGACCTGGAGCCGAT	0.582			NA											8	39					0.000274275	0.00083082	0.00448238	1	0
DNM1	1759	broad.mit.edu	37	9	130984836	130984836	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:130984836C>G	uc011mau.1	+	8	1176	c.1089C>G	c.(1087-1089)AAC>AAG	p.N363K	DNM1_uc010mxr.2_Missense_Mutation_p.N363K|DNM1_uc011mat.1_Missense_Mutation_p.N363K	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	363					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						CCCGCATTAACCGAATCTTCC	0.592	GBM(113;146 1575 2722 28670 29921)		NA											6	45					0	0	0.00448238	0	0
TBC1D13	54662	broad.mit.edu	37	9	131568291	131568291	+	Missense_Mutation	SNP	A	A	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:131568291A>G	uc010myj.2	+	10	1195	c.1072A>G	c.(1072-1074)ATG>GTG	p.M358V	TBC1D13_uc010myk.2_Missense_Mutation_p.M233V|TBC1D13_uc010myl.2_Missense_Mutation_p.M177V	NM_018201	NP_060671	Q9NVG8	TBC13_HUMAN	TBC1 domain family, member 13	358						intracellular	Rab GTPase activator activity				0						CTGCTGCGCCATGCTCATGTG	0.622			NA											7	21					0	0	0.00198382	0	0
CAMSAP1	157922	broad.mit.edu	37	9	138719314	138719314	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:138719314C>T	uc004cgr.3	-	8	1162	c.1162G>A	c.(1162-1164)GTG>ATG	p.V388M	CAMSAP1_uc004cgq.3_Missense_Mutation_p.V278M|CAMSAP1_uc010nbg.2_Missense_Mutation_p.V110M	NM_015447	NP_056262	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein	388						cytoplasm|microtubule				ovary(1)|central_nervous_system(1)|pancreas(1)	3				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		GGCAGCTGCACGGGGGGCTGC	0.597			NA											5	18					0	0	0.000602214	0	0
TLR8	51311	broad.mit.edu	37	X	12939365	12939365	+	Missense_Mutation	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:12939365A>T	uc004cve.2	+	2	2274	c.2206A>T	c.(2206-2208)AGT>TGT	p.S736C	TLR8_uc004cvd.2_Missense_Mutation_p.S754C	NM_138636	NP_619542	Q9NR97	TLR8_HUMAN	toll-like receptor 8 precursor	736	Extracellular (Potential).				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			ovary(4)|lung(2)|large_intestine(1)	7						TTCTGAAGTCAGTAGTCTGAA	0.413			NA											15	127					0	0	0.00316338	0	0
SMS	6611	broad.mit.edu	37	X	21996187	21996187	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:21996187G>T	uc004dag.2	+	6	716	c.615G>T	c.(613-615)TTG>TTT	p.L205F	SMS_uc011mjq.1_Missense_Mutation_p.L109F|SMS_uc004daf.1_Missense_Mutation_p.L152F|SMS_uc010nfs.2_5'Flank|SMS_uc010nft.2_5'Flank	NM_004595	NP_004586	P52788	SPSY_HUMAN	spermine synthase	205					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			ovary(1)	1					Spermine(DB00127)	GAGGCATATTGTGTGAAATAG	0.428			NA											15	59					6.31663e-08	2.36392e-07	0.00316338	1	0
FAM47A	158724	broad.mit.edu	37	X	34149860	34149860	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:34149860G>T	uc004ddg.2	-	1	569	c.536C>A	c.(535-537)CCT>CAT	p.P179H		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	179	Pro-rich.									ovary(4)|central_nervous_system(1)	5						ATGTTTACCAGGCTCAGTGGG	0.577			NA											5	24					1.6384e-10	6.76905e-10	0.00198382	1	0
FAM47C	442444	broad.mit.edu	37	X	37028698	37028698	+	Missense_Mutation	SNP	C	C	T	rs144392292		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:37028698C>T	uc004ddl.1	+	1	2229	c.2215C>T	c.(2215-2217)CGC>TGC	p.R739C		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	739										ovary(3)	3						GTCCCATCTCCGCCCAGAGCC	0.637			NA											12	41					0	0	0.00185496	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40458862	40458862	+	Silent	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:40458862C>T	uc004det.2	+	7	709	c.607C>T	c.(607-609)CTA>TTA	p.L203L	ATP6AP2_uc010nhc.2_RNA|ATP6AP2_uc011mkl.1_Silent_p.L127L|ATP6AP2_uc011mkm.1_Silent_p.L171L|ATP6AP2_uc011mkn.1_Silent_p.L125L|ATP6AP2_uc004deu.1_Silent_p.L68L	NM_005765	NP_005756	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory	203	Extracellular (Potential).				angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity				0						TCATAAGCATCTAGCCAAGGA	0.408			NA											6	71					0	0	0.00307968	0	0
PHF16	9767	broad.mit.edu	37	X	46917717	46917717	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:46917717C>G	uc004dgx.2	+	11	1761	c.1710C>G	c.(1708-1710)AGC>AGG	p.S570R	PHF16_uc004dgy.2_Missense_Mutation_p.S570R	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	570					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						CTGACAGCAGCTCATCTGTTC	0.458			NA											8	53					0	0	0.000442599	0	0
XAGE5	170627	broad.mit.edu	37	X	52844149	52844149	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:52844149C>A	uc004drd.1	+	4	277	c.212C>A	c.(211-213)TCT>TAT	p.S71Y		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	71										ovary(1)	1						CAGGAGCTGTCTCAGTCAAAG	0.443			NA											10	44					0.000442599	0.0013229	0.000442599	1	0
KLF8	11279	broad.mit.edu	37	X	56296679	56296679	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:56296679C>A	uc004dur.2	+	5	1769	c.823C>A	c.(823-825)CAA>AAA	p.Q275K	KLF8_uc011mop.1_Intron|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	275	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACGGATTCACCAATGTGACTT	0.493			NA											8	53					1.12685e-05	3.70408e-05	0.00448238	1	0
ZXDB	158586	broad.mit.edu	37	X	57620764	57620764	+	Silent	SNP	A	A	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:57620764A>T	uc004dvd.2	+	1	2496	c.2283A>T	c.(2281-2283)GTA>GTT	p.V761V		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	761					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AGTGGAACGTACATCCTGACT	0.473			NA											11	83					0	0	0.000673444	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722958	64722958	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:64722958C>G	uc010nko.2	+	5	2356	c.2347C>G	c.(2347-2349)CAG>GAG	p.Q783E		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	783							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						ACACCAGTATCAGACCTACAA	0.498			NA											5	45					0	0	0.000602214	0	0
EDA	1896	broad.mit.edu	37	X	69255360	69255360	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:69255360G>T	uc004dxs.2	+	8	1319	c.1077G>T	c.(1075-1077)AAG>AAT	p.K359N	EDA_uc004dxr.2_Missense_Mutation_p.K357N|EDA_uc011mpj.1_Missense_Mutation_p.K354N	NM_001399	NP_001390	Q92838	EDA_HUMAN	ectodysplasin A isoform EDA-A1	359	Extracellular (Potential).				cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			ovary(2)|large_intestine(1)	3						CCCGGCAGAAGATCGCCGTCA	0.577			NA											7	39					8.12818e-05	0.000254784	0.00198382	1	0
TEX11	56159	broad.mit.edu	37	X	69774579	69774579	+	Missense_Mutation	SNP	C	C	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:69774579C>A	uc004dyl.2	-	27	2419	c.2257G>T	c.(2257-2259)GAT>TAT	p.D753Y	TEX11_uc004dyk.2_Missense_Mutation_p.D428Y|TEX11_uc004dym.2_Missense_Mutation_p.D738Y	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	753							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					AGTAATGGATCATTCAATTTG	0.363			NA											17	44					9.16793e-09	3.56942e-08	0.000566183	1	0
ZMYM3	9203	broad.mit.edu	37	X	70465222	70465222	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:70465222G>C	uc004dzh.1	-	18	3061	c.2974C>G	c.(2974-2976)CCT>GCT	p.P992A	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.P992A|ZMYM3_uc004dzj.1_Missense_Mutation_p.P980A	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	992					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCTTGCCCAGGCTCATCCAAG	0.547			NA											4	25					0	0	0.00024832	0	0
PHKA1	5255	broad.mit.edu	37	X	71840645	71840645	+	Missense_Mutation	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:71840645G>C	uc004eax.3	-	19	2368	c.2067C>G	c.(2065-2067)TTC>TTG	p.F689L	PHKA1_uc004eay.3_Missense_Mutation_p.F689L|PHKA1_uc011mqi.1_Intron	NM_002637	NP_002628	P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle) isoform	689					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(3)|skin(1)	4	Renal(35;0.156)					CAGCAGCTTGGAACCGATCTA	0.512			NA											5	33					0	0	0.000602214	0	0
ATRX	546	broad.mit.edu	37	X	76845317	76845317	+	Silent	SNP	G	G	C			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:76845317G>C	uc004ecp.3	-	27	6436	c.6204C>G	c.(6202-6204)CCC>CCG	p.P2068P	ATRX_uc004ecq.3_Silent_p.P2030P|ATRX_uc004eco.3_Silent_p.P1853P	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2068	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TATAAATAAGGGGTTTATCTT	0.308			NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						5	40					0	0	0.00116845	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912566	77912567	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:77912566_77912567GG>TT	uc004edc.1	-	2	1647_1648	c.1351_1352CC>AA	c.(1351-1353)CCT>AAT	p.P451N		NM_152694	NP_689907	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	451	CCHC-type.						nucleic acid binding|zinc ion binding			ovary(1)	1						AAAATGACCAGGATAACCACAG	0.554			NA											5	22					0	0	6.4e-05	0	0
TBX22	50945	broad.mit.edu	37	X	79279561	79279562	+	Splice_Site	DNP	GG	GG	TT			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:79279561_79279562GG>TT	uc010nmg.1	+	4	491	c.357_splice	c.e4-1	p.R119_splice	TBX22_uc004edi.1_Splice_Site|TBX22_uc004edj.1_Splice_Site_p.R119_splice	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1						multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						CTTTCTTACAGGCGGATGTTCC	0.48			NA											7	61					0	0	6.4e-05	0	0
BRWD3	254065	broad.mit.edu	37	X	79978262	79978262	+	Missense_Mutation	SNP	T	T	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:79978262T>A	uc004edt.2	-	17	1938	c.1675A>T	c.(1675-1677)ACG>TCG	p.T559S	BRWD3_uc004edo.2_Missense_Mutation_p.T155S|BRWD3_uc004edp.2_Missense_Mutation_p.T388S|BRWD3_uc004edq.2_Missense_Mutation_p.T155S|BRWD3_uc010nmj.1_Missense_Mutation_p.T155S|BRWD3_uc004edr.2_Missense_Mutation_p.T229S|BRWD3_uc004eds.2_Missense_Mutation_p.T155S|BRWD3_uc004edu.2_Missense_Mutation_p.T229S|BRWD3_uc004edv.2_Missense_Mutation_p.T155S|BRWD3_uc004edw.2_Missense_Mutation_p.T155S|BRWD3_uc004edx.2_Missense_Mutation_p.T155S|BRWD3_uc004edy.2_Missense_Mutation_p.T155S|BRWD3_uc004edz.2_Missense_Mutation_p.T229S|BRWD3_uc004eea.2_Missense_Mutation_p.T229S|BRWD3_uc004eeb.2_Missense_Mutation_p.T155S	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	559										ovary(4)	4						CGATAATCCGTGTGGAAGAAC	0.388			NA											26	68					0	0	0.00127121	0	0
SATL1	340562	broad.mit.edu	37	X	84363384	84363384	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:84363384G>A	uc011mqx.1	-	1	591	c.591C>T	c.(589-591)GGC>GGT	p.G197G	SATL1_uc004een.2_Silent_p.G197G	NM_001163541	NP_001157013	Q86VE3	SATL1_HUMAN	spermidine/spermine N1-acetyl transferase-like 1	10	Gln-rich.						N-acetyltransferase activity			breast(2)	2						GTTGTTGCACGCCTGGTTGCC	0.572			NA											19	75					0	0	0.000958276	0	0
SEPT6	23157	broad.mit.edu	37	X	118767439	118767439	+	Missense_Mutation	SNP	C	C	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:118767439C>T	uc004erv.2	-	8	1238	c.973G>A	c.(973-975)GAG>AAG	p.E325K	SEPT6_uc010nqk.2_Intron|SEPT6_uc004ers.2_Missense_Mutation_p.E325K|SEPT6_uc004ert.2_Missense_Mutation_p.E325K|SEPT6_uc004eru.2_Missense_Mutation_p.E325K|SEPT6_uc004erw.2_Missense_Mutation_p.E267K|SEPT6_uc011mtv.1_Missense_Mutation_p.E267K|SEPT6_uc011mtw.1_Missense_Mutation_p.E355K	NM_015129	NP_055944	Q14141	SEPT6_HUMAN	septin 6 isoform B	325	Potential.				cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			lung(1)|ovary(1)|prostate(1)|kidney(1)	4						CTTTTGGCCTCATATGTCTCC	0.448			NA											62	119					0	0	0.00361006	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795247	142795247	+	Missense_Mutation	SNP	G	G	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:142795247G>T	uc004fbz.2	-	2	1185	c.431C>A	c.(430-432)TCT>TAT	p.S144Y		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	144										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					AGATCCTTCAGATGAGTCCAG	0.522			NA											72	176					5.0909e-33	2.5954e-32	0.00361006	1	0
AFF2	2334	broad.mit.edu	37	X	147744018	147744018	+	Missense_Mutation	SNP	C	C	G			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:147744018C>G	uc004fcp.2	+	3	1249	c.770C>G	c.(769-771)TCT>TGT	p.S257C	AFF2_uc004fco.2_Missense_Mutation_p.S253C|AFF2_uc004fcq.2_Missense_Mutation_p.S253C|AFF2_uc004fcr.2_Missense_Mutation_p.S253C|AFF2_uc011mxb.1_Missense_Mutation_p.S257C|AFF2_uc004fcs.2_Missense_Mutation_p.S253C	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	257					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGCTTCCTCTTTATTAGCT	0.478			NA											7	138					0	0	0.00198382	0	0
CNGA2	1260	broad.mit.edu	37	X	150911608	150911608	+	Silent	SNP	G	G	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chrX:150911608G>A	uc004fey.1	+	7	857	c.633G>A	c.(631-633)CTG>CTA	p.L211L		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	211	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCAAGAAACTGCGAGACAACT	0.488			NA											10	34					0	0	0.000673444	0	0
ACADM	34	broad.mit.edu	37	1	76211563	76211563	+	Frame_Shift_Del	DEL	G	G	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:76211563delG	uc001dgw.3	+	8	1102	c.672delG	c.(670-672)GTGfs	p.V224fs	ACADM_uc010ord.1_Frame_Shift_Del_p.V138fs|ACADM_uc009wbp.2_Frame_Shift_Del_p.V228fs|ACADM_uc009wbr.2_Frame_Shift_Del_p.V257fs|ACADM_uc010ore.1_Frame_Shift_Del_p.V188fs|ACADM_uc010orf.1_Frame_Shift_Del_p.V35fs|ACADM_uc001dgx.3_Frame_Shift_Del_p.V138fs|ACADM_uc010org.1_Frame_Shift_Del_p.V94fs|ACADM_uc009wbs.1_RNA	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	224					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						GATTCATTGTGGAAGCAGATA	0.343			NA											13	97	---	---	---	---	NA	NA	NA	NA	NA
RBM34	23029	broad.mit.edu	37	1	235324345	235324345	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:235324345delC	uc001hwn.2	-	2	121	c.91delG	c.(91-93)GAAfs	p.E31fs	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Frame_Shift_Del_p.E31fs	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	31						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CTGTAGTCTTCCGGCGGACTC	0.607			NA											12	18	---	---	---	---	NA	NA	NA	NA	NA
OR2B11	127623	broad.mit.edu	37	1	247614468	247614468	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr1:247614468delC	uc010pyx.1	-	1	817	c.817delG	c.(817-819)GAGfs	p.E273fs		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	273	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TTGCCCTGCTCTTGGGAGTAG	0.493			NA											17	126	---	---	---	---	NA	NA	NA	NA	NA
MICALCL	84953	broad.mit.edu	37	11	12316384	12316389	+	In_Frame_Del	DEL	CTCCTA	CTCCTA	-	rs3812754	byFrequency	TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	CTCCTA	CTCCTA	-	-	CTCCTA	CTCCTA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:12316384_12316389delCTCCTA	uc001mkg.1	+	3	1697_1702	c.1406_1411delCTCCTA	c.(1405-1413)CCTCCTACA>CCA	p.PT470del		NM_032867	NP_116256	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	470_471					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			skin(1)	1				Epithelial(150;0.00177)		cctcctcctcctcctACAGCGGGAGG	0.432			NA											4	2	---	---	---	---	NA	NA	NA	NA	NA
OR5D14	219436	broad.mit.edu	37	11	55563619	55563619	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr11:55563619delC	uc010rim.1	+	1	588	c.588delC	c.(586-588)ATCfs	p.I196fs		NM_001004735	NP_001004735	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3		all_epithelial(135;0.196)				ATATACTCATCCCCCACCTGC	0.418			NA											19	181	---	---	---	---	NA	NA	NA	NA	NA
PABPC3	5042	broad.mit.edu	37	13	25671273	25671273	+	Frame_Shift_Del	DEL	G	G	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr13:25671273delG	uc001upy.2	+	1	998	c.937delG	c.(937-939)GCGfs	p.A313fs		NM_030979	NP_112241	Q9H361	PABP3_HUMAN	poly(A) binding protein, cytoplasmic 3	313	RRM 4.				mRNA metabolic process	cytoplasm	nucleotide binding|poly(A) RNA binding			ovary(3)|skin(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		TCTCCGGAAAGCGTTTTCTCC	0.408			NA											7	292	---	---	---	---	NA	NA	NA	NA	NA
NID2	22795	broad.mit.edu	37	14	52526841	52526841	+	Splice_Site	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr14:52526841delC	uc001wzo.2	-	3	1001	c.767_splice	c.e3+1	p.Q256_splice	NID2_uc010tqs.1_Splice_Site_p.Q256_splice|NID2_uc010tqt.1_Splice_Site_p.Q256_splice|NID2_uc001wzp.2_Splice_Site_p.Q256_splice	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor							basement membrane	calcium ion binding|collagen binding	p.?(1)		pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					ATGTTACTTACTGATAGAGAT	0.418			NA											7	35	---	---	---	---	NA	NA	NA	NA	NA
KIF2B	84643	broad.mit.edu	37	17	51901016	51901016	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr17:51901016delC	uc002iua.2	+	1	778	c.622delC	c.(622-624)CCCfs	p.P208fs	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	208					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						AGTCCTGGAGCCCCCGCAAGA	0.552			NA											8	26	---	---	---	---	NA	NA	NA	NA	NA
CARD8	22900	broad.mit.edu	37	19	48733883	48733883	+	Frame_Shift_Del	DEL	G	G	-	rs148180647		TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr19:48733883delG	uc002pie.3	-	6	842	c.529delC	c.(529-531)CGGfs	p.R177fs	CARD8_uc002pii.3_Frame_Shift_Del_p.R283fs|CARD8_uc010xzi.1_Frame_Shift_Del_p.R178fs|CARD8_uc010els.2_Frame_Shift_Del_p.R216fs|CARD8_uc010xzj.1_Frame_Shift_Del_p.R283fs|CARD8_uc010xzk.1_Frame_Shift_Del_p.R202fs|CARD8_uc002pif.3_Frame_Shift_Del_p.R177fs|CARD8_uc002pig.3_Frame_Shift_Del_p.R8fs|CARD8_uc002pih.3_Frame_Shift_Del_p.R233fs|CARD8_uc010xzl.1_Frame_Shift_Del_p.R233fs|CARD8_uc010xzm.1_Frame_Shift_Del_p.R283fs	NM_014959	NP_055774	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	177					negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity				0		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		GGCTCCACCCGGGCTGGATGC	0.577			NA											11	75	---	---	---	---	NA	NA	NA	NA	NA
LRP2	4036	broad.mit.edu	37	2	170134449	170134450	+	Frame_Shift_Ins	INS	-	-	A			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr2:170134449_170134450insA	uc002ues.2	-	13	1790_1791	c.1577_1578insT	c.(1576-1578)TTCfs	p.F526fs	LRP2_uc010zdf.1_Intron	NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	526	LDL-receptor class B 3.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CCCAATCTGAGAAAAATAAATA	0.391			NA											16	73	---	---	---	---	NA	NA	NA	NA	NA
TMPRSS15	5651	broad.mit.edu	37	21	19770237	19770238	+	Frame_Shift_Ins	INS	-	-	T			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr21:19770237_19770238insT	uc002ykw.2	-	3	333_334	c.302_303insA	c.(301-303)AATfs	p.N101fs		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor	101	Extracellular (Potential).|SEA.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						CATTCTTCAGATTGCTTGATAG	0.243			NA											7	28	---	---	---	---	NA	NA	NA	NA	NA
TBC1D2	55357	broad.mit.edu	37	9	100971254	100971254	+	Frame_Shift_Del	DEL	C	C	-			TCGA-53-7626-01A-12D-2063-08	TCGA-53-7626-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0dc05a31-557a-4026-af11-f2dfdb91d5f3	5eea1eb3-ae16-4285-a8cb-d71ebfaa362b	g.chr9:100971254delC	uc011lvb.1	-	9	2026	c.1846delG	c.(1846-1848)GCCfs	p.A616fs	TBC1D2_uc004ayp.2_Frame_Shift_Del_p.A156fs|TBC1D2_uc004ayq.2_Frame_Shift_Del_p.A616fs|TBC1D2_uc004ayr.2_Frame_Shift_Del_p.A398fs|TBC1D2_uc004ayo.3_Frame_Shift_Del_p.A616fs	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	616						cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		TTGAGCTCGGCTGAGGGCACA	0.672			NA											7	42	---	---	---	---	NA	NA	NA	NA	NA