Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MIB2	142678	broad.mit.edu	37	1	1563878	1563878	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:1563878G>A	uc001agg.2	+	16	2279	c.2152G>A	c.(2152-2154)GAC>AAC	p.D718N	MIB2_uc001agh.2_Missense_Mutation_p.D704N|MIB2_uc001agi.2_Missense_Mutation_p.D714N|MIB2_uc001agj.2_Missense_Mutation_p.D559N|MIB2_uc001agk.2_Missense_Mutation_p.D653N|MIB2_uc001agl.1_Missense_Mutation_p.D674N|MIB2_uc001agm.2_Missense_Mutation_p.D595N|MIB2_uc010nyq.1_Missense_Mutation_p.D674N|MIB2_uc009vkh.2_Missense_Mutation_p.D524N|MIB2_uc001agn.2_Missense_Mutation_p.D350N|MIB2_uc001ago.2_5'Flank	NM_080875	NP_543151	Q96AX9	MIB2_HUMAN	mindbomb homolog 2	718	ANK 6.				Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GGGCCGCTGTGACGTGAACGT	0.726			NA											8	27					0	0	0.00308	0	0
PANK4	55229	broad.mit.edu	37	1	2440356	2440356	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:2440356G>C	uc001ajm.1	-	19	2261	c.2252C>G	c.(2251-2253)GCG>GGG	p.A751G	PANK4_uc010nza.1_Missense_Mutation_p.A712G	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	751					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GGCCAGCCACGCGTTCTTGAT	0.652			NA											9	8					0	0	0.010729	0	0
PTCHD2	57540	broad.mit.edu	37	1	11596438	11596438	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:11596438G>T	uc001ash.3	+	21	4012	c.3874G>T	c.(3874-3876)GCC>TCC	p.A1292S		NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1292	Helical; (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CGTGGGCGTGGCCATCGTCTC	0.657			NA											38	69					9.8876e-21	1.27919e-20	0.021022	1	0
SPATA21	374955	broad.mit.edu	37	1	16727321	16727321	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:16727321C>T	uc001ayn.2	-	11	1551	c.1068G>A	c.(1066-1068)CGG>CGA	p.R356R	SPATA21_uc001ayl.1_RNA|SPATA21_uc010occ.1_Silent_p.R333R	NM_198546	NP_940948	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	356							calcium ion binding			ovary(2)|breast(1)	3		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		GCAACCGCAGCCGGCCTACGG	0.592			NA											115	293					0	0	0.01441	0	0
PLA2G2A	5320	broad.mit.edu	37	1	20304613	20304613	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:20304613A>T	uc001bcu.2	-	4	405	c.187T>A	c.(187-189)TGC>AGC	p.C63S	PLA2G2A_uc001bcv.2_Missense_Mutation_p.C63S|PLA2G2A_uc010oda.1_Missense_Mutation_p.C63S|PLA2G2A_uc010odb.1_Missense_Mutation_p.C63S	NM_001161729	NP_001155201	P14555	PA2GA_HUMAN	phospholipase A2, group IIA precursor	63					defense response to Gram-positive bacterium|lipid catabolic process|low-density lipoprotein particle remodeling|phosphatidic acid metabolic process|positive regulation of inflammatory response|positive regulation of macrophage derived foam cell differentiation	endoplasmic reticulum|extracellular space|membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|phospholipid binding				0		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00459)|Lung NSC(340;0.00475)|Breast(348;0.00526)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000138)|Kidney(64;0.000171)|GBM - Glioblastoma multiforme(114;0.00032)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GTGACACAGCAGCTGTGAGGA	0.562			NA											24	58					0	0	0.021523	0	0
ZBTB40	9923	broad.mit.edu	37	1	22837737	22837737	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:22837737C>A	uc001bft.2	+	11	2410	c.1899C>A	c.(1897-1899)GCC>GCA	p.A633A	ZBTB40_uc001bfu.2_Silent_p.A633A|ZBTB40_uc009vqi.1_Silent_p.A521A|ZBTB40_uc001bfv.1_Silent_p.A262A	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	633					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		TGAGCAGAGCCATGGAAAAAT	0.512			NA											42	234					4.67007e-22	6.08195e-22	0.00874	1	0
LIN28A	79727	broad.mit.edu	37	1	26738039	26738039	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:26738039C>T	uc001bmj.2	+	2	308	c.194C>T	c.(193-195)GCG>GTG	p.A65V	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	65	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						GCCGGGGTCGCGCTCGACCCC	0.647			NA											43	99					0	0	0.01441	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33954745	33954745	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:33954745C>T	uc001bxj.3	+	4	802	c.635C>T	c.(634-636)CCA>CTA	p.P212L	ZSCAN20_uc001bxk.2_Intron|ZSCAN20_uc009vui.2_Missense_Mutation_p.P212L	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	212					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCTACTCTCCCAAAGATGGGG	0.517			NA											16	54					0	0	0.008871	0	0
CSMD2	114784	broad.mit.edu	37	1	34554714	34554714	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:34554714C>A	uc001bxn.1	-	2	177	c.148G>T	c.(148-150)GCC>TCC	p.A50S	CSMD2_uc001bxm.1_Missense_Mutation_p.A90S	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	50	CUB 1.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTGCAGTTGGCGTAATTGGGG	0.552			NA											21	56					4.4004e-07	4.84539e-07	0.01892	1	0
NCDN	23154	broad.mit.edu	37	1	36029491	36029491	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:36029491G>A	uc001bza.2	+	7	1861	c.1734G>A	c.(1732-1734)CGG>CGA	p.R578R	NCDN_uc001bzb.2_Silent_p.R578R|NCDN_uc001bzc.2_Silent_p.R561R	NM_001014839	NP_001014839	Q9UBB6	NCDN_HUMAN	neurochondrin isoform 1	578					neuron projection development	cytosol|dendrite|neuronal cell body				large_intestine(2)|pancreas(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TCATGGCCCGGCTCCTTAGCA	0.572			NA											23	59					0	0	0.014323	0	0
MTF1	4520	broad.mit.edu	37	1	38280877	38280877	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:38280877A>T	uc001cce.1	-	11	2334	c.2193T>A	c.(2191-2193)AAT>AAA	p.N731K		NM_005955	NP_005946	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	731						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			ovary(1)|pancreas(1)	2	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				TGGGAATCAGATTGGACGGGG	0.547			NA											6	158					0	0	0.001168	0	0
MACF1	23499	broad.mit.edu	37	1	39765882	39765882	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:39765882G>C	uc010ois.1	+	23	2702	c.2497G>C	c.(2497-2499)GAT>CAT	p.D833H	MACF1_uc001cda.1_Missense_Mutation_p.D741H|MACF1_uc001cdc.1_5'UTR|MACF1_uc009vvq.1_5'UTR|MACF1_uc001cdb.1_5'UTR	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	833					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CATTTTGTAGGATGAAAAGGA	0.418			NA											16	180					0	0	0.006122	0	0
MACF1	23499	broad.mit.edu	37	1	39788376	39788376	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:39788376A>G	uc010ois.1	+	33	4346	c.4141A>G	c.(4141-4143)ATC>GTC	p.I1381V	MACF1_uc001cda.1_Missense_Mutation_p.I1289V|MACF1_uc001cdc.1_Missense_Mutation_p.I468V|MACF1_uc009vvq.1_Missense_Mutation_p.I438V|MACF1_uc001cdb.1_Missense_Mutation_p.I468V	NM_012090	NP_036222	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	1381					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTCAGATGCCATCACTCAAGA	0.488			NA											33	91					0	0	0.010818	0	0
NFYC	4802	broad.mit.edu	37	1	41236480	41236480	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:41236480C>T	uc001cge.2	+	10	1365	c.1357C>T	c.(1357-1359)CCC>TCC	p.P453S	NFYC_uc001cfx.3_Missense_Mutation_p.P349S|NFYC_uc009vwd.2_Missense_Mutation_p.P330S|NFYC_uc001cfz.2_Missense_Mutation_p.P329S|NFYC_uc010ojn.1_Missense_Mutation_p.P292S|NFYC_uc001cfy.3_Missense_Mutation_p.P330S|NFYC_uc001cgc.2_Missense_Mutation_p.P296S|NFYC_uc001cgb.2_Missense_Mutation_p.P434S|NFYC_uc001cgd.3_Missense_Mutation_p.P330S	NM_001142588	NP_001136060	Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma isoform 1	453					protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|kidney(1)	3	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			CGGGCAGGCCCCCCAGGTGAC	0.642			NA											20	111					0	0	0.010504	0	0
EDN2	1907	broad.mit.edu	37	1	41948217	41948217	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:41948217C>T	uc001cgx.2	-	3	336	c.264G>A	c.(262-264)CGG>CGA	p.R88R	EDN2_uc001cgu.2_RNA|EDN2_uc001cgv.2_RNA|EDN2_uc009vwh.2_5'UTR|EDN2_uc001cgw.2_RNA|EDN2_uc009vwi.2_Intron|EDN2_uc009vwj.2_Intron	NM_001956	NP_001947	P20800	EDN2_HUMAN	endothelin 2 preproprotein	88					artery smooth muscle contraction|calcium-mediated signaling|cytokine-mediated signaling pathway|elevation of cytosolic calcium ion concentration|hormonal regulation of the force of heart contraction|inositol phosphate-mediated signaling|macrophage activation|macrophage chemotaxis|neutrophil chemotaxis|positive regulation of cell proliferation|positive regulation of heart rate|positive regulation of leukocyte chemotaxis|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of the force of heart contraction by chemical signal|prostaglandin biosynthetic process|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	extracellular space	endothelin B receptor binding|hormone activity				0	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGGAGCGGCGCCGGCGTCTTG	0.617			NA											13	22					0	0	0.004007	0	0
ELAVL4	1996	broad.mit.edu	37	1	50659526	50659526	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:50659526G>A	uc001csb.2	+	4	712	c.444G>A	c.(442-444)CTG>CTA	p.L148L	ELAVL4_uc001cry.3_Silent_p.L151L|ELAVL4_uc001crz.3_Silent_p.L148L|ELAVL4_uc001csa.3_Silent_p.L165L|ELAVL4_uc001csc.3_Silent_p.L148L|ELAVL4_uc009vyu.2_Silent_p.L153L|ELAVL4_uc010omz.1_Silent_p.L153L	NM_021952	NP_068771	P26378	ELAV4_HUMAN	ELAV-like 4 isoform 1	148	RRM 2.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			ovary(1)|pancreas(1)	2						AGAAGGAACTGGAGCAACTTT	0.463			NA											82	190					0	0	0.01441	0	0
NRD1	4898	broad.mit.edu	37	1	52301803	52301803	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:52301803T>C	uc001ctc.3	-	5	1238	c.916A>G	c.(916-918)ATG>GTG	p.M306V	NRD1_uc009vzb.2_Missense_Mutation_p.M1V|NRD1_uc001ctd.3_Missense_Mutation_p.M238V|NRD1_uc001cte.2_Missense_Mutation_p.M174V|NRD1_uc001ctf.2_Missense_Mutation_p.M238V|NRD1_uc010ong.1_RNA|NRD1_uc009vzc.1_Missense_Mutation_p.M106V	NM_002525	NP_002516	O43847	NRDC_HUMAN	nardilysin isoform a	237					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding				0						AAATTCTTACTGTGCTCCAAA	0.423			NA											21	46					0	0	0.014323	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704107	52704107	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:52704107C>T	uc001cto.2	+	4	1190	c.1018C>T	c.(1018-1020)CTT>TTT	p.L340F	ZFYVE9_uc001ctn.2_Missense_Mutation_p.L340F|ZFYVE9_uc001ctp.2_Missense_Mutation_p.L340F	NM_004799	NP_004790	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9 isoform 3	340					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			ovary(2)|lung(2)|central_nervous_system(2)|skin(2)	8						TTTACCTTTGCTTCTCAAACC	0.453			NA											54	123					0	0	0.01441	0	0
TTC22	55001	broad.mit.edu	37	1	55266541	55266541	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:55266541T>C	uc009vzt.1	-	1	401	c.296A>G	c.(295-297)AAC>AGC	p.N99S	TTC22_uc001cxz.3_Missense_Mutation_p.N99S	NM_001114108	NP_001107580	Q5TAA0	TTC22_HUMAN	tetratricopeptide repeat domain 22 isoform 1	99	TPR 1.						binding				0						GGCATTGAGGTTGCCCGGGTG	0.687			NA											13	15					0	0	0.013537	0	0
SERBP1	26135	broad.mit.edu	37	1	67878931	67878931	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:67878931G>C	uc001ddv.2	-	8	1326	c.1186C>G	c.(1186-1188)CCT>GCT	p.P396A	SERBP1_uc001ddx.2_Missense_Mutation_p.P390A|SERBP1_uc001ddy.2_Missense_Mutation_p.P375A|SERBP1_uc001ddw.2_Missense_Mutation_p.P381A	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	396					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						TCCACATCAGGAGCAGAAGCA	0.418			NA											4	47					0	0	0.001984	0	0
DIRAS3	9077	broad.mit.edu	37	1	68512673	68512673	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:68512673C>A	uc001ded.2	-	2	603	c.308G>T	c.(307-309)CGC>CTC	p.R103L	uc001deb.1_Intron|uc001dec.1_Intron	NM_004675	NP_004666	O95661	DIRA3_HUMAN	DIRAS family, GTP-binding RAS-like 3	103					regulation of cyclin-dependent protein kinase activity|regulation of gene expression by genetic imprinting|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			skin(1)	1						TATAACGTGGCGCTGCAGAGC	0.577			NA											58	308					1.13205e-32	1.54352e-32	0.01441	1	0
NEGR1	257194	broad.mit.edu	37	1	72163734	72163734	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:72163734A>T	uc001dfw.2	-	4	724	c.624T>A	c.(622-624)GAT>GAA	p.D208E	NEGR1_uc001dfv.2_Missense_Mutation_p.D80E|NEGR1_uc010oqs.1_Intron	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	208	Ig-like C2-type 2.			D -> A (in Ref. 2).	cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GGAATGACACATCATTTTCCG	0.353			NA											21	125					0	0	0.014323	0	0
ZZZ3	26009	broad.mit.edu	37	1	78098634	78098634	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:78098634G>A	uc001dhq.2	-	5	882	c.406C>T	c.(406-408)CCT>TCT	p.P136S	ZZZ3_uc001dhr.2_Intron|ZZZ3_uc009wbz.1_Missense_Mutation_p.P136S|ZZZ3_uc001dhp.2_Missense_Mutation_p.P136S	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						GATTTTATAGGAGAATCTTCT	0.383			NA											89	172					0	0	0.01441	0	0
GBP3	2635	broad.mit.edu	37	1	89481013	89481013	+	Missense_Mutation	SNP	G	G	A	rs142900270	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:89481013G>A	uc001dmt.2	-	3	480	c.275C>T	c.(274-276)ACC>ATC	p.T92I	GBP3_uc010oss.1_Missense_Mutation_p.T13I|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	92						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		CAGGACTAAGGTGTGTTCTGG	0.458			NA											34	243					0	0	0.013726	0	0
GBP3	2635	broad.mit.edu	37	1	89481019	89481019	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:89481019T>G	uc001dmt.2	-	3	474	c.269A>C	c.(268-270)GAA>GCA	p.E90A	GBP3_uc010oss.1_Missense_Mutation_p.E11A|GBP3_uc001dmu.2_5'UTR|GBP3_uc001dmv.2_RNA	NM_018284	NP_060754	Q9H0R5	GBP3_HUMAN	guanylate binding protein 3	90						integral to membrane	GTP binding|GTPase activity			ovary(1)|pancreas(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0103)|Epithelial(280;0.0293)		TAAGGTGTGTTCTGGCTTTTT	0.458			NA											33	244					0	0	0.010818	0	0
LRRC8C	84230	broad.mit.edu	37	1	90178876	90178876	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:90178876G>T	uc001dnl.3	+	3	989	c.747G>T	c.(745-747)AGG>AGT	p.R249S		NM_032270	NP_115646	Q8TDW0	LRC8C_HUMAN	leucine rich repeat containing 8 family, member	249						endoplasmic reticulum membrane|integral to membrane				ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8		all_lung(203;0.126)		all cancers(265;0.00756)|Epithelial(280;0.0313)		AGAAGTTCAGGCTGCATGTGG	0.403			NA											52	108					3.77171e-38	5.19688e-38	0.01441	1	0
ZNF644	84146	broad.mit.edu	37	1	91406850	91406850	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:91406850C>A	uc001dnw.2	-	3	203	c.61G>T	c.(61-63)GGG>TGG	p.G21W	ZNF644_uc001dnv.2_Intron|ZNF644_uc001dnx.2_Intron|ZNF644_uc001dny.1_Missense_Mutation_p.G21W	NM_201269	NP_958357	Q9H582	ZN644_HUMAN	zinc finger protein 644 isoform 1	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTGGCAAGCCCATTTAACACA	0.299			NA											29	136					1.90571e-15	2.34181e-15	0.019004	1	0
LPPR5	163404	broad.mit.edu	37	1	99470209	99470209	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:99470209C>T	uc001dsb.2	-	1	241	c.19G>A	c.(19-21)GCG>ACG	p.A7T	uc001dsd.1_Intron|LPPR5_uc001dsc.2_Missense_Mutation_p.A7T	NM_001037317	NP_001032394	Q32ZL2	LPPR5_HUMAN	phosphatidic acid phosphatase type 2d isoform 1	7						integral to membrane	hydrolase activity				0						CTGGTGAGCGCCGCGGGCAGC	0.572			NA											39	63					0	0	0.010771	0	0
OLFM3	118427	broad.mit.edu	37	1	102271669	102271669	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:102271669C>A	uc001duf.2	-	5	793	c.722G>T	c.(721-723)TGG>TTG	p.W241L	OLFM3_uc001dug.2_Missense_Mutation_p.W221L|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.W146L|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	241	Olfactomedin-like.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		GTCTGTCATCCAAGCACCAAA	0.408			NA											49	156					2.55665e-31	3.45588e-31	0.01441	1	0
COL11A1	1301	broad.mit.edu	37	1	103461446	103461446	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:103461446C>A	uc001dul.2	-	28	2632	c.2314G>T	c.(2314-2316)GGT>TGT	p.G772C	COL11A1_uc001duk.2_Translation_Start_Site|COL11A1_uc001dum.2_Missense_Mutation_p.G784C|COL11A1_uc001dun.2_Missense_Mutation_p.G733C|COL11A1_uc009weh.2_Missense_Mutation_p.G656C	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	772	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCCTTGAGACCTCTGACACCA	0.279			NA											4	192					1.23904e-05	1.32887e-05	0.014758	1	0
EPS8L3	79574	broad.mit.edu	37	1	110294756	110294756	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:110294756T>C	uc001dyr.1	-	15	1440	c.1295A>G	c.(1294-1296)CAT>CGT	p.H432R	EPS8L3_uc001dys.1_Intron|EPS8L3_uc001dyq.1_Missense_Mutation_p.H433R|EPS8L3_uc009wfm.1_Intron|EPS8L3_uc009wfn.1_Intron	NM_133181	NP_573444	Q8TE67	ES8L3_HUMAN	epidermal growth factor receptor pathway	432						cytoplasm	protein binding			ovary(2)|skin(1)	3		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		CTGAGGGTCATGGTTGTGTGT	0.562			NA											123	302					0	0	0.01441	0	0
KCNA2	3737	broad.mit.edu	37	1	111146592	111146592	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:111146592C>T	uc001dzu.2	-	2	1309	c.813G>A	c.(811-813)GGG>GGA	p.G271G	KCNA2_uc009wfv.1_Silent_p.G271G|KCNA2_uc009wfw.2_Silent_p.G271G	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	271	Helical; Name=Segment S3; (Potential).					juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		CCAACTCTGTCCCCAGGGTGA	0.532	Pancreas(18;568 735 10587 23710 36357)		NA											43	185					0	0	0.010771	0	0
KCNA2	3737	broad.mit.edu	37	1	111147346	111147346	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:111147346T>C	uc001dzu.2	-	2	555	c.59A>G	c.(58-60)CAG>CGG	p.Q20R	KCNA2_uc009wfv.1_Missense_Mutation_p.Q20R|KCNA2_uc009wfw.2_Missense_Mutation_p.Q20R	NM_004974	NP_004965	P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related	20						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(1)	1		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		ATAGGTGTCCTGTGGGTGCCC	0.587	Pancreas(18;568 735 10587 23710 36357)		NA											108	243					0	0	0.01441	0	0
C1orf103	55791	broad.mit.edu	37	1	111494316	111494316	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:111494316T>C	uc001eaa.2	-	2	1446	c.1190A>G	c.(1189-1191)CAG>CGG	p.Q397R	C1orf103_uc001dzz.2_Intron|C1orf103_uc001eab.2_Intron|C1orf103_uc001eac.1_Intron	NM_018372	NP_060842	Q5T3J3	LRIF1_HUMAN	receptor-interacting factor 1 isoform 1	397					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding				0		all_cancers(81;1.02e-05)|all_epithelial(167;1.87e-05)|all_lung(203;0.000234)|Lung NSC(277;0.000451)		Lung(183;0.0155)|Colorectal(144;0.0314)|all cancers(265;0.082)|LUSC - Lung squamous cell carcinoma(189;0.0826)|Epithelial(280;0.0891)|COAD - Colon adenocarcinoma(174;0.134)		ACTCACTGTCTGTAACGTGTC	0.393			NA											69	367					0	0	0.01441	0	0
DDX20	11218	broad.mit.edu	37	1	112308806	112308806	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:112308806A>G	uc001ebs.2	+	11	2117	c.1760A>G	c.(1759-1761)TAC>TGC	p.Y587C	DDX20_uc010owf.1_Missense_Mutation_p.Y349C|DDX20_uc001ebt.2_Missense_Mutation_p.Y195C	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	587					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCAGCCATACACGTTGACT	0.443			NA											82	161					0	0	0.01441	0	0
ZNF697	90874	broad.mit.edu	37	1	120165639	120165639	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:120165639C>T	uc001ehy.1	-	3	1441	c.1327G>A	c.(1327-1329)GGG>AGG	p.G443R		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	443	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		AAGCCCTTCCCGCACTCGCGG	0.667			NA											4	10					0	0	0.009096	0	0
FLG	2312	broad.mit.edu	37	1	152285774	152285774	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:152285774A>G	uc001ezu.1	-	3	1624	c.1588T>C	c.(1588-1590)TCC>CCC	p.S530P	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	530	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCGTGGTGGGATCCCTGCCTT	0.602			NA							Ichthyosis				15	893					0	0	0.014323	0	0
LCE3A	353142	broad.mit.edu	37	1	152595433	152595433	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:152595433C>G	uc010pdt.1	-	1	147	c.147G>C	c.(145-147)CTG>CTC	p.L49L		NM_178431	NP_848518	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	49					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGGTGACTCAGGCAGCAGC	0.657			NA											12	134					0	0	0.004007	0	0
INSRR	3645	broad.mit.edu	37	1	156823768	156823768	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:156823768G>T	uc010pht.1	-	2	667	c.413C>A	c.(412-414)GCT>GAT	p.A138D	NTRK1_uc001fqf.1_Intron|NTRK1_uc009wsi.1_Intron|INSRR_uc009wsj.1_Missense_Mutation_p.A138D	NM_014215	NP_055030	P14616	INSRR_HUMAN	insulin receptor-related receptor precursor	138					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|insulin receptor substrate binding|metal ion binding|phosphatidylinositol 3-kinase binding|transmembrane receptor protein tyrosine kinase activity			lung(11)|ovary(5)|skin(2)|kidney(1)|central_nervous_system(1)	20	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CACACGCACAGCCCCACGCAG	0.632			NA											28	45					2.44723e-14	2.97001e-14	0.004656	1	0
OR10T2	128360	broad.mit.edu	37	1	158368853	158368853	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:158368853A>C	uc010pih.1	-	1	404	c.404T>G	c.(403-405)CTC>CGC	p.L135R		NM_001004475	NP_001004475	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T,	135	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GTTTATGATGAGTGTGTACCT	0.463			NA											45	185					0	0	0.01441	0	0
OR6N1	128372	broad.mit.edu	37	1	158735615	158735615	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:158735615G>A	uc010piq.1	-	1	858	c.858C>T	c.(856-858)AAC>AAT	p.N286N		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	286	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGATGAAGGGGTTGAGGAAGG	0.527			NA											86	268					0	0	0.01441	0	0
SLAMF9	89886	broad.mit.edu	37	1	159923368	159923368	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:159923368G>T	uc001fus.2	-	2	239	c.122C>A	c.(121-123)CCC>CAC	p.P41H	SLAMF9_uc009wtd.2_Missense_Mutation_p.P41H|SLAMF9_uc001fut.2_Missense_Mutation_p.P41H	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	41	Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TATTTCCAGGGGGAGGCTGAT	0.527			NA											69	130					2.18329e-32	2.9717e-32	0.01441	1	0
FCRLB	127943	broad.mit.edu	37	1	161692781	161692781	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:161692781C>A	uc001gbh.2	+	4	268	c.34C>A	c.(34-36)CCA>ACA	p.P12T	FCRLB_uc009wus.2_Missense_Mutation_p.P12T|FCRLB_uc001gbj.2_Missense_Mutation_p.P12T|FCRLB_uc001gbk.2_Missense_Mutation_p.P12T|FCRLB_uc001gbl.2_Intron|FCRLB_uc001gbm.2_Intron|FCRLB_uc001gbi.2_Missense_Mutation_p.P12T|FCRLB_uc001gbn.3_5'Flank	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	12						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			TTCTGCAGTTCCAAGCAGTGG	0.458			NA											45	84					8.86878e-18	1.1125e-17	0.01441	1	0
RGS4	5999	broad.mit.edu	37	1	163043250	163043250	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:163043250G>C	uc009wuy.2	+	4	727	c.216G>C	c.(214-216)GGG>GGC	p.G72G	RGS4_uc001gcl.3_Silent_p.G169G|RGS4_uc009wuz.2_Intron|RGS4_uc009wva.2_Silent_p.G54G	NM_005613	NP_005604	P49798	RGS4_HUMAN	regulator of G-protein signaling 4 isoform 2	72	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			ovary(2)|central_nervous_system(1)	3						TCATAGGTGGGCTGGCAGCTT	0.423	Ovarian(76;1257 1738 3039 6086)		NA											36	136					0	0	0.00623	0	0
RGS5	8490	broad.mit.edu	37	1	163172591	163172591	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:163172591C>A	uc001gcn.2	-	1	282	c.35G>T	c.(34-36)TGC>TTC	p.C12F	RGS5_uc009wvb.2_RNA	NM_003617	NP_003608	O15539	RGS5_HUMAN	regulator of G-protein signalling 5	12					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity				0			LUSC - Lung squamous cell carcinoma(543;0.187)			CCTTTCCAGGCATGAGTGGGG	0.448			NA											15	45					1.02788e-11	1.21182e-11	0.00499	1	0
MAEL	84944	broad.mit.edu	37	1	166973415	166973415	+	Splice_Site	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:166973415A>G	uc001gdy.1	+	6	595	c.524_splice	c.e6-2	p.S175_splice	MAEL_uc001gdz.1_Splice_Site_p.S144_splice|MAEL_uc009wvf.1_Splice_Site	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog						cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						TATTTCCCTCAGGTGATTCTA	0.378			NA											9	177					0	0	0.008291	0	0
XCL1	6375	broad.mit.edu	37	1	168550295	168550295	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:168550295T>C	uc001gfo.1	+	3	202	c.182T>C	c.(181-183)ATT>ACT	p.I61T		NM_002995	NP_002986	P47992	XCL1_HUMAN	chemokine (C motif) ligand 1	61					CD4-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell proliferation|cell-cell signaling|cellular response to interleukin-4|cellular response to transforming growth factor beta stimulus|immunoglobulin production in mucosal tissue|lymphocyte chemotaxis|negative regulation of interferon-gamma production|negative regulation of interleukin-2 production|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T cell cytokine production|negative regulation of T-helper 1 cell activation|negative regulation of transcription, DNA-dependent|neutrophil chemotaxis|positive regulation of activated T cell proliferation|positive regulation of B cell chemotaxis|positive regulation of granzyme A production|positive regulation of granzyme B production|positive regulation of interleukin-10 production|positive regulation of natural killer cell chemotaxis|positive regulation of neutrophil chemotaxis|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell chemotaxis|positive regulation of T cell cytokine production|positive regulation of T cell mediated cytotoxicity|positive regulation of thymocyte migration|positive regulation of transforming growth factor-beta production|regulation of inflammatory response|release of sequestered calcium ion into cytosol|response to virus|T-helper 1 cell cytokine production|T-helper 2 cell cytokine production	extracellular space	chemokine activity|protein homodimerization activity				0	all_hematologic(923;0.208)					TACAGTTTTATTACCAAACGT	0.468			NA											30	46					0	0	0.008361	0	0
C1orf156	92342	broad.mit.edu	37	1	169761944	169761944	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:169761944T>C	uc001ggn.2	-	2	1171	c.893A>G	c.(892-894)AAC>AGC	p.N298S	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	298						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATAATCTGGGTTGTAAATGGT	0.343			NA											12	55					0	0	0.013537	0	0
TNN	63923	broad.mit.edu	37	1	175063368	175063368	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:175063368G>A	uc001gkl.1	+	7	1680	c.1567G>A	c.(1567-1569)GCT>ACT	p.A523T	TNN_uc010pmx.1_Missense_Mutation_p.A523T	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	523	Fibronectin type-III 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GAGCAAGAAAGCTGACACCAA	0.532			NA											16	111					0	0	0.004007	0	0
TNR	7143	broad.mit.edu	37	1	175331897	175331897	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:175331897G>C	uc001gkp.1	-	12	2837	c.2756C>G	c.(2755-2757)ACC>AGC	p.T919S	TNR_uc009wwu.1_Missense_Mutation_p.T919S	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	919	Fibronectin type-III 7.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCTGGTGATGGTGAATTCTGT	0.517			NA											45	153					0	0	0.01441	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564340	176564340	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:176564340G>T	uc001gkz.2	+	3	2764	c.1600G>T	c.(1600-1602)GAT>TAT	p.D534Y	PAPPA2_uc001gky.1_Missense_Mutation_p.D534Y|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	534	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GAACATCTGTGATGATGAGGG	0.527			NA											53	79					1.21353e-23	1.59633e-23	0.01441	1	0
CACNA1E	777	broad.mit.edu	37	1	181548245	181548245	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:181548245G>T	uc001gow.2	+	5	819	c.654G>T	c.(652-654)ATG>ATT	p.M218I	CACNA1E_uc009wxr.2_Missense_Mutation_p.M125I|CACNA1E_uc009wxs.2_Missense_Mutation_p.M125I	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	218	Cytoplasmic (Potential).|I.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						TGAAGGCCATGGTACCTCTTC	0.488			NA											9	162					0.000442599	0.000462664	0.006214	1	0
LAMC2	3918	broad.mit.edu	37	1	183189974	183189974	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:183189974A>T	uc001gqa.2	+	5	832	c.518A>T	c.(517-519)TAC>TTC	p.Y173F	LAMC2_uc001gpz.3_Missense_Mutation_p.Y173F|LAMC2_uc010poa.1_5'UTR	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	173	Laminin EGF-like 3.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						CGATCAGGTTACTATAATCTG	0.443			NA											47	81					0	0	0.01441	0	0
RGL1	23179	broad.mit.edu	37	1	183885633	183885633	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:183885633C>T	uc001gqo.2	+	16	1959	c.1802C>T	c.(1801-1803)TCC>TTC	p.S601F	RGL1_uc001gqm.2_Missense_Mutation_p.S636F|RGL1_uc010pog.1_Missense_Mutation_p.S599F|RGL1_uc010poh.1_Missense_Mutation_p.S599F|RGL1_uc010poi.1_Missense_Mutation_p.S572F	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	601	Ser-rich.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						GACACAAATTCCTCAGGGATG	0.507			NA											61	209					0	0	0.01441	0	0
RGS1	5996	broad.mit.edu	37	1	192547444	192547445	+	Missense_Mutation	DNP	GA	GA	AG			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:192547444_192547445GA>AG	uc001gsi.1	+	4	439_440	c.373_374GA>AG	c.(373-375)GAG>AGG	p.E125R	RGS1_uc010pou.1_Missense_Mutation_p.E125R	NM_002922	NP_002913	Q08116	RGS1_HUMAN	regulator of G-protein signalling 1	125	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity				0		Breast(1374;0.188)				TAAGAAAACAGAGTCTGATCTT	0.366			NA											62	198					0	0	0.004672	0	0
CFHR5	81494	broad.mit.edu	37	1	196971714	196971714	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:196971714G>T	uc001gts.3	+	8	1378	c.1250G>T	c.(1249-1251)TGT>TTT	p.C417F		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	417	Sushi 7.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						GCTGTTCTCTGTAAAGAAAAC	0.388			NA											19	58					7.21436e-19	9.18192e-19	0.008871	1	0
PRELP	5549	broad.mit.edu	37	1	203452913	203452913	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:203452913G>T	uc001gzs.2	+	2	801	c.601G>T	c.(601-603)GAT>TAT	p.D201Y	PRELP_uc001gzt.2_Missense_Mutation_p.D201Y	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	201	Poly-Leu.|LRR 5.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCTGCTCCTGGATCTCCAGCA	0.607			NA											31	313					1.30897e-18	1.66326e-18	0.009535	1	0
SLC45A3	85414	broad.mit.edu	37	1	205631992	205631992	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:205631992C>G	uc001hda.1	-	3	1266	c.927G>C	c.(925-927)CCG>CCC	p.P309P	SLC45A3_uc010prn.1_5'Flank|SLC45A3_uc010pro.1_Silent_p.P143P|SLC45A3_uc010prp.1_Intron|ELK4_uc010prq.1_Intron	NM_033102	NP_149093	Q96JT2	S45A3_HUMAN	prostein	309					transmembrane transport	integral to membrane		p.P309L(1)	SLC45A3/BRAF(2)	ovary(2)|prostate(2)	4	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			CCTCGGTGCCCGGCTCAGCTC	0.632			NA	T	ETV1|ETV5|ELK4|ERG	prostate 								27	91					0	0	0.005443	0	0
PIGR	5284	broad.mit.edu	37	1	207112588	207112588	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:207112588C>A	uc001hez.2	-	3	448	c.264G>T	c.(262-264)CCG>CCT	p.P88P	PIGR_uc009xbz.2_Silent_p.P88P	NM_002644	NP_002635	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor precursor	88	Ig-like V-type 1.|Extracellular (Potential).					extracellular region|integral to plasma membrane	protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3						TGCCGTTCTCCGGGAAGTTGG	0.592			NA											16	91					1.3612e-06	1.4884e-06	0.003163	1	0
CR1L	1379	broad.mit.edu	37	1	207867885	207867885	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:207867885G>A	uc001hga.3	+	5	772	c.651G>A	c.(649-651)TGG>TGA	p.W217*	CR1L_uc001hfz.2_RNA|CR1L_uc001hgb.1_RNA	NM_175710	NP_783641	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	217	Sushi 3.					cytoplasm|extracellular region|membrane					0						TGGGCATCTGGAGTGGCCCAG	0.463			NA											67	411					0	0	0.01441	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213445953	213445953	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:213445953G>C	uc010ptr.1	+	15	3336	c.3177G>C	c.(3175-3177)GTG>GTC	p.V1059V	RPS6KC1_uc001hkd.2_Silent_p.V1047V|RPS6KC1_uc010pts.1_Silent_p.V847V|RPS6KC1_uc010ptt.1_Silent_p.V847V|RPS6KC1_uc010ptu.1_Silent_p.V878V|RPS6KC1_uc010ptv.1_Silent_p.V594V|RPS6KC1_uc001hke.2_Silent_p.V878V	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	1059					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		TTACCCCTGTGGATTGGGCAG	0.458			NA											9	126					0	0	0.006214	0	0
DISP1	84976	broad.mit.edu	37	1	223178410	223178410	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:223178410C>G	uc001hnu.1	+	8	3818	c.3671C>G	c.(3670-3672)GCA>GGA	p.A1224G		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1224					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AACAGCCAAGCAAAGAATTTA	0.473			NA											42	115					0	0	0.00623	0	0
LIN9	286826	broad.mit.edu	37	1	226426782	226426782	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:226426782G>A	uc001hqa.2	-	12	1493	c.1183C>T	c.(1183-1185)CCC>TCC	p.P395S	LIN9_uc001hqb.2_Missense_Mutation_p.P360S|LIN9_uc001hqc.2_Missense_Mutation_p.P327S|LIN9_uc009xel.1_Missense_Mutation_p.P360S	NM_173083	NP_775106	Q5TKA1	LIN9_HUMAN	lin-9 homolog	379	Potential.				cell cycle|DNA replication	nucleoplasm					0	Breast(184;0.158)			GBM - Glioblastoma multiforme(131;0.131)		ATGCTGATGGGCATGGAATAT	0.343	Ovarian(197;1696 2974 11248 14117)		NA											13	123					0	0	0.016723	0	0
JMJD4	65094	broad.mit.edu	37	1	227920196	227920196	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:227920196G>A	uc001hrb.2	-	6	1289	c.1289C>T	c.(1288-1290)GCG>GTG	p.A430V	SNAP47_uc001hqz.2_Intron|SNAP47_uc001hra.2_Intron|SNAP47_uc001hrd.2_5'Flank|SNAP47_uc001hre.2_5'Flank|SNAP47_uc001hrf.2_5'Flank|LOC100130093_uc001hqx.3_RNA|LOC100130093_uc001hqy.3_RNA|JMJD4_uc001hrc.2_Missense_Mutation_p.A414V	NM_023007	NP_075383	Q9H9V9	JMJD4_HUMAN	jumonji domain containing 4 isoform 1	430											0		Prostate(94;0.0885)				GTCGGGGTGCGCAACCAAGGA	0.627			NA											5	156					0	0	0.014758	0	0
OBSCN	84033	broad.mit.edu	37	1	228509331	228509331	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:228509331G>T	uc009xez.1	+	55	14833	c.14789G>T	c.(14788-14790)CGC>CTC	p.R4930L	OBSCN_uc001hsn.2_Missense_Mutation_p.R4930L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	4930	Ig-like 48.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GTGCGAGCCCGCTGGCTGAAG	0.642			NA											29	37					3.65163e-15	4.48025e-15	0.00632	1	0
AGT	183	broad.mit.edu	37	1	230845985	230845985	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:230845985C>A	uc001hty.3	-	2	1120	c.612G>T	c.(610-612)CTG>CTT	p.L204L	AGT_uc009xfe.2_Silent_p.L204L|AGT_uc009xff.2_Silent_p.L176L	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	204					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	CCGTGGACAGCAGCAGCTGGG	0.667			NA											25	52					3.6726e-16	4.53436e-16	0.021523	1	0
ACTN2	88	broad.mit.edu	37	1	236889278	236889278	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:236889278C>A	uc001hyf.2	+	5	698	c.494C>A	c.(493-495)ACT>AAT	p.T165N	ACTN2_uc001hyg.2_Translation_Start_Site|ACTN2_uc009xgi.1_Missense_Mutation_p.T165N	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	165	CH 2.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CAGAGGAAAACTGCTCCTTAT	0.478			NA											13	322					4.3838e-07	4.8407e-07	0.016723	1	0
RYR2	6262	broad.mit.edu	37	1	237802406	237802406	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:237802406G>A	uc001hyl.1	+	46	7140	c.7020G>A	c.(7018-7020)GGG>GGA	p.G2340G		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2340	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGAAGGTGGGAATGGGCTTC	0.502			NA											19	46					0	0	0.012319	0	0
RYR2	6262	broad.mit.edu	37	1	237948113	237948114	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:237948113_237948114GG>TT	uc001hyl.1	+	90	13221_13222	c.13101_13102GG>TT	c.(13099-13104)AAGGAG>AATTAG	p.4367_4368KE>N*	RYR2_uc010pya.1_Nonsense_Mutation_p.782_783KE>N*	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4367_4368					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCGACTTAAAGGAGCTGACAGA	0.535			NA											48	58					0	0	0.004672	0	0
FMN2	56776	broad.mit.edu	37	1	240493928	240493928	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:240493928T>C	uc010pyd.1	+	11	4688	c.4463T>C	c.(4462-4464)ATG>ACG	p.M1488T	FMN2_uc010pye.1_Missense_Mutation_p.M1492T|FMN2_uc010pyf.1_Missense_Mutation_p.M134T|FMN2_uc010pyg.1_Missense_Mutation_p.M84T	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1488	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCAGGGGTTATGCAGGTTCTA	0.383			NA											52	84					0	0	0.01441	0	0
EXO1	9156	broad.mit.edu	37	1	242048689	242048689	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:242048689G>T	uc001hzh.2	+	15	2825	c.2285G>T	c.(2284-2286)AGA>ATA	p.R762I	EXO1_uc001hzi.2_Missense_Mutation_p.R762I|EXO1_uc001hzj.2_Missense_Mutation_p.R762I|EXO1_uc009xgq.2_Missense_Mutation_p.R761I	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	762	Interaction with MSH2.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			GGACCTGCCAGAGCCAGTGGG	0.478			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					25	44					6.00712e-18	7.57168e-18	0.012213	1	0
HNRNPU	3192	broad.mit.edu	37	1	245018903	245018903	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:245018903C>T	uc001iaz.1	-	12	2393	c.2175G>A	c.(2173-2175)GGG>GGA	p.G725G	HNRNPU_uc001iaw.1_RNA|HNRNPU_uc001iax.1_RNA|HNRNPU_uc001iay.1_Silent_p.G449G|HNRNPU_uc001iba.1_Silent_p.G706G	NM_031844	NP_114032	Q00839	HNRPU_HUMAN	heterogeneous nuclear ribonucleoprotein U	725	RNA-binding RGG-box.|Gly-rich.				CRD-mediated mRNA stabilization	catalytic step 2 spliceosome|cell surface|CRD-mediated mRNA stability complex|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	ATP binding|DNA binding|protein binding|RNA binding				0	all_cancers(71;6.97e-06)|all_epithelial(71;0.000104)|all_neural(11;0.0269)|Breast(184;0.0545)|Glioma(6;0.0724)|Ovarian(71;0.0761)|all_lung(81;0.0989)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.00868)			CGCCACGATTCCCAGGGGCTA	0.468	NSCLC(33;911 1010 3329 23631 49995)		NA											11	90					0	0	0.003163	0	0
OR2G2	81470	broad.mit.edu	37	1	247751695	247751695	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:247751695C>G	uc010pyy.1	+	1	34	c.34C>G	c.(34-36)CTA>GTA	p.L12V		NM_001001915	NP_001001915	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G,	12	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGAGAGCAACCTAGCAGGTTT	0.393			NA											106	132					0	0	0.01441	0	0
SH3BP5L	80851	broad.mit.edu	37	1	249107312	249107312	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:249107312C>A	uc001iew.1	-	6	1139	c.587G>T	c.(586-588)CGA>CTA	p.R196L	SH3BP5L_uc010pzp.1_Missense_Mutation_p.R89L|SH3BP5L_uc010pzq.1_Missense_Mutation_p.R164L|SH3BP5L_uc001iev.1_Missense_Mutation_p.R77L	NM_030645	NP_085148	Q7L8J4	3BP5L_HUMAN	SH3-binding domain protein 5-like	196	Potential.										0	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.19)	OV - Ovarian serous cystadenocarcinoma(106;0.00805)			CCGAGTCACTCGCTGGTGCTC	0.637			NA											5	6					2.14196e-07	2.38198e-07	0.007291	1	0
SFMBT2	57713	broad.mit.edu	37	10	7325987	7325987	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:7325987G>A	uc009xio.1	-	6	742	c.651C>T	c.(649-651)CGC>CGT	p.R217R	SFMBT2_uc001ijn.1_Silent_p.R217R|SFMBT2_uc010qay.1_Silent_p.R217R	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	217	MBT 2.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						CATAGCGAAGGCGTAATCTTC	0.413			NA											11	173					0	0	0.016723	0	0
TAF3	83860	broad.mit.edu	37	10	8056639	8056639	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:8056639G>C	uc010qbd.1	+	7	2715	c.2715G>C	c.(2713-2715)ATG>ATC	p.M905I		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	905	PHD-type.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						CAGAAGAGATGCAGTGGTTCT	0.507			NA											16	43					0	0	0.00499	0	0
C10orf47	254427	broad.mit.edu	37	10	11911910	11911910	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:11911910G>T	uc001ikx.2	+	4	967	c.813G>T	c.(811-813)CTG>CTT	p.L271L	uc001iky.1_Intron	NM_153256	NP_694988	Q86WR7	CJ047_HUMAN	hypothetical protein LOC254427	271										central_nervous_system(1)	1						GCAGGACCCTGTCCAGGGCGG	0.657			NA											6	2					0.000442599	0.000462664	0.006214	1	0
NUDT5	11164	broad.mit.edu	37	10	12209745	12209745	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:12209745G>T	uc001ilj.2	-	10	1032	c.616C>A	c.(616-618)CAT>AAT	p.H206N	SEC61A2_uc001ilf.3_Intron|SEC61A2_uc001ilh.3_Intron|SEC61A2_uc001ilg.3_Intron|uc001ili.1_5'Flank|NUDT5_uc001ilk.2_3'UTR	NM_014142	NP_054861	Q9UKK9	NUDT5_HUMAN	nudix-type motif 5	206					D-ribose catabolic process|ribonucleoside diphosphate catabolic process	intracellular	ADP-ribose diphosphatase activity|magnesium ion binding			ovary(1)|pancreas(1)	2		Renal(717;0.228)				GCATTTGCATGTTTCAGTGCT	0.443			NA											103	109					1.07597e-44	1.50636e-44	0.01441	1	0
PTPLA	9200	broad.mit.edu	37	10	17636321	17636321	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:17636321C>T	uc001ipg.2	-	6	702	c.667G>A	c.(667-669)GCT>ACT	p.A223T		NM_014241	NP_055056	B0YJ81	HACD1_HUMAN	protein tyrosine phosphatase-like, member A	223	Lumenal (Potential).				fatty acid biosynthetic process|multicellular organismal development|signal transduction	endoplasmic reticulum membrane|integral to membrane	lyase activity|protein tyrosine phosphatase activity			central_nervous_system(1)|skin(1)	2						GGCAAGGCAGCGTATATTGTA	0.313			NA											5	99					0	0	0.014758	0	0
ARMC3	219681	broad.mit.edu	37	10	23270366	23270366	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:23270366A>T	uc001irm.3	+	9	1097	c.1014A>T	c.(1012-1014)CAA>CAT	p.Q338H	ARMC3_uc010qcv.1_Missense_Mutation_p.Q338H|ARMC3_uc010qcw.1_Missense_Mutation_p.Q75H	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	338	ARM 8.						binding				0						CTGCTTCCCAAGCTATTTCAG	0.363			NA											4	71					0	0	0.009096	0	0
ARMC3	219681	broad.mit.edu	37	10	23292330	23292330	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:23292330A>G	uc001irm.3	+	13	1801	c.1718A>G	c.(1717-1719)TAT>TGT	p.Y573C	ARMC3_uc010qcv.1_Missense_Mutation_p.Y573C|ARMC3_uc010qcw.1_Missense_Mutation_p.Y310C	NM_173081	NP_775104	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	573							binding				0						GATGGATTCTATGATTATGGT	0.333			NA											100	90					0	0	0.01441	0	0
ARMC4	55130	broad.mit.edu	37	10	28260243	28260243	+	Splice_Site	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:28260243C>A	uc009xky.2	-	8	1035	c.937_splice	c.e8-1	p.G313_splice	ARMC4_uc010qds.1_Intron|ARMC4_uc010qdt.1_Splice_Site_p.G5_splice|ARMC4_uc001itz.2_Splice_Site_p.G313_splice|ARMC4_uc010qdu.1_Splice_Site_p.G5_splice	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4								binding			ovary(4)|skin(2)	6						AGCTAATTCCCTTTATTTAAA	0.388			NA											7	61					0.00198382	0.00205458	0.001984	1	0
ZEB1	6935	broad.mit.edu	37	10	31810791	31810791	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:31810791A>G	uc001ivs.3	+	7	2591	c.2528A>G	c.(2527-2529)TAC>TGC	p.Y843C	ZEB1_uc001ivr.3_Missense_Mutation_p.Y625C|ZEB1_uc010qee.1_Missense_Mutation_p.Y625C|ZEB1_uc010qef.1_Missense_Mutation_p.Y625C|ZEB1_uc009xlj.1_Missense_Mutation_p.Y769C|ZEB1_uc010qeg.1_Missense_Mutation_p.Y702C|ZEB1_uc009xlk.1_Missense_Mutation_p.Y625C|ZEB1_uc001ivt.3_Missense_Mutation_p.Y625C|ZEB1_uc001ivu.3_Missense_Mutation_p.Y844C|ZEB1_uc001ivv.3_Missense_Mutation_p.Y823C|ZEB1_uc010qeh.1_Missense_Mutation_p.Y776C|ZEB1_uc009xlo.1_Missense_Mutation_p.Y826C|ZEB1_uc009xlp.2_Missense_Mutation_p.Y827C	NM_030751	NP_110378	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1 isoform b	843					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(3)|central_nervous_system(2)	5		Prostate(175;0.0156)				CAGGTGGCATACACCTACTCA	0.483	Ovarian(40;423 959 14296 36701 49589)		NA											58	47					0	0	0.01441	0	0
CUL2	8453	broad.mit.edu	37	10	35327986	35327986	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:35327986C>A	uc001ixv.2	-	9	949	c.739G>T	c.(739-741)GAA>TAA	p.E247*	CUL2_uc009xma.2_Nonsense_Mutation_p.E116*|CUL2_uc010qer.1_Nonsense_Mutation_p.E266*|CUL2_uc001ixw.2_Nonsense_Mutation_p.E247*|CUL2_uc010qes.1_Nonsense_Mutation_p.E184*	NM_003591	NP_003582	Q13617	CUL2_HUMAN	cullin 2	247					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			ovary(3)	3						CATCGAATTTCTTCATCTTTT	0.318			NA											6	54					0.00198382	0.00205458	0.001984	1	0
FRMPD2	143162	broad.mit.edu	37	10	49371699	49371699	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:49371699C>T	uc001jgi.2	-	28	3660	c.3553G>A	c.(3553-3555)GCT>ACT	p.A1185T	FRMPD2_uc001jgh.2_Missense_Mutation_p.A1153T|FRMPD2_uc001jgj.2_Missense_Mutation_p.A1163T|FRMPD2L1_uc001jgf.2_Missense_Mutation_p.A196T|FRMPD2_uc001jgg.2_Missense_Mutation_p.A137T|FRMPD2_uc001jgk.2_Missense_Mutation_p.A137T	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	1185					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		TCTTTGTCAGCTGAGAGTTCA	0.458			NA											11	193					0	0	0.006122	0	0
ASAH2	56624	broad.mit.edu	37	10	52005145	52005145	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:52005145C>A	uc001jjd.2	-	2	197	c.197G>T	c.(196-198)CGC>CTC	p.R66L	ASAH2_uc009xos.2_Missense_Mutation_p.R66L	NM_019893	NP_063946	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase 2 isoform a	66	Lumenal (Potential).				apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity				0						GGCTGTGGAGCGTTGGGCAGC	0.507			NA											35	66					1.61788e-16	2.01336e-16	0.012213	1	0
PCDH15	65217	broad.mit.edu	37	10	55591271	55591271	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:55591271C>A	uc001jju.1	-	30	4401	c.4006G>T	c.(4006-4008)GAT>TAT	p.D1336Y	PCDH15_uc010qhq.1_Missense_Mutation_p.D1341Y|PCDH15_uc010qhr.1_Missense_Mutation_p.D1336Y|PCDH15_uc010qhs.1_Missense_Mutation_p.D1348Y|PCDH15_uc010qht.1_Missense_Mutation_p.D1343Y|PCDH15_uc010qhu.1_Missense_Mutation_p.D1336Y|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D1336Y|PCDH15_uc010qhw.1_Missense_Mutation_p.D1299Y|PCDH15_uc010qhx.1_Missense_Mutation_p.D1265Y|PCDH15_uc010qhy.1_Missense_Mutation_p.D1341Y|PCDH15_uc010qhz.1_Missense_Mutation_p.D1336Y|PCDH15_uc010qia.1_Missense_Mutation_p.D1314Y|PCDH15_uc010qib.1_Missense_Mutation_p.D1314Y	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1336	Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTATTGATATCAAGTAGTTTG	0.353			NA								HNSCC(58;0.16)			26	65					3.17567e-06	3.43885e-06	0.008361	1	0
ANK3	288	broad.mit.edu	37	10	61874084	61874084	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:61874084T>C	uc001jky.2	-	26	3039	c.2847A>G	c.(2845-2847)CTA>CTG	p.L949L	ANK3_uc001jkw.2_Silent_p.L83L|ANK3_uc009xpa.2_Silent_p.L83L|ANK3_uc001jkx.2_Silent_p.L127L|ANK3_uc010qih.1_Silent_p.L950L|ANK3_uc001jkz.3_Silent_p.L943L|ANK3_uc001jla.1_Silent_p.L15L|ANK3_uc001jlb.1_Silent_p.L456L	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	949					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTGTGAATGTTAGATGCTGAA	0.328			NA											10	63					0	0	0.006214	0	0
HERC4	26091	broad.mit.edu	37	10	69716678	69716678	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:69716678G>T	uc001jng.3	-	18	2317	c.2006C>A	c.(2005-2007)GCA>GAA	p.A669E	HERC4_uc009xpq.2_Missense_Mutation_p.A202E|HERC4_uc001jnf.3_RNA|HERC4_uc001jnh.3_Missense_Mutation_p.A661E|HERC4_uc009xpr.2_Missense_Mutation_p.A669E|HERC4_uc001jni.3_Missense_Mutation_p.A405E	NM_022079	NP_071362	Q5GLZ8	HERC4_HUMAN	hect domain and RLD 4 isoform a	669					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			ovary(1)|breast(1)|skin(1)	3						AGTAGTTTTTGCTTGGGCATC	0.318			NA											8	156					9.05144e-12	1.06872e-11	0.016723	1	0
USP54	159195	broad.mit.edu	37	10	75289573	75289573	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:75289573C>G	uc001juo.2	-	13	1942	c.1925G>C	c.(1924-1926)CGG>CCG	p.R642P	USP54_uc001juk.2_5'UTR|USP54_uc001jul.2_5'UTR|USP54_uc001jum.2_RNA|USP54_uc001jun.2_RNA|USP54_uc001jup.2_Missense_Mutation_p.R642P|USP54_uc010qkl.1_Missense_Mutation_p.R642P	NM_152586	NP_689799	Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	642					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(3)|lung(2)|kidney(1)	6	Prostate(51;0.0112)					AGAGCCTGGCCGTGCTGGGCC	0.522	Colon(195;880 2046 8854 25025 38456)		NA									OREG0020266	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	174					0	0	0.01441	0	0
KCNMA1	3778	broad.mit.edu	37	10	78708951	78708951	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:78708951G>C	uc001jxn.2	-	22	2835	c.2658C>G	c.(2656-2658)CTC>CTG	p.L886L	KCNMA1_uc001jxj.2_Silent_p.L832L|KCNMA1_uc001jxk.1_Silent_p.L504L|KCNMA1_uc009xrt.1_Silent_p.L677L|KCNMA1_uc001jxl.1_Silent_p.L511L|KCNMA1_uc001jxo.2_Silent_p.L869L|KCNMA1_uc001jxm.2_Silent_p.L828L|KCNMA1_uc001jxq.2_Silent_p.L831L	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	886	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	ATTCCCGCTTGAGGTACTCAA	0.483			NA											9	188					0	0	0.008291	0	0
CDHR1	92211	broad.mit.edu	37	10	85968522	85968522	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:85968522C>T	uc001kcv.2	+	12	1205	c.1205C>T	c.(1204-1206)CCC>CTC	p.P402L	CDHR1_uc001kcw.2_Missense_Mutation_p.P402L|CDHR1_uc009xst.2_Missense_Mutation_p.P161L	NM_033100	NP_149091	Q96JP9	CDHR1_HUMAN	protocadherin 21 precursor	402	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion		calcium ion binding|receptor activity			ovary(1)	1						CTGGTGGGACCCAGGGGCATC	0.443			NA											6	43					0	0	0.001984	0	0
PAPSS2	9060	broad.mit.edu	37	10	89475536	89475536	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:89475536C>G	uc001kex.2	+	7	1064	c.801C>G	c.(799-801)CCC>CCG	p.P267P	PAPSS2_uc001kew.2_Silent_p.P267P|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	267	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		GGGCCACTCCCCTCAAAGGTT	0.438			NA											8	45					0	0	0.00308	0	0
LIPM	340654	broad.mit.edu	37	10	90572926	90572926	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:90572926A>T	uc009xtm.1	+	3	505	c.338A>T	c.(337-339)AAC>ATC	p.N113I	LIPM_uc009xtn.1_Missense_Mutation_p.N88I	NM_001128215	NP_001121687	Q5VYY2	LIPM_HUMAN	lipase, family member M precursor	113					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)	1						AACCTGCCCAACAATAGCCTG	0.498			NA											5	16					0	0	0.014758	0	0
CEP55	55165	broad.mit.edu	37	10	95263113	95263113	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:95263113G>C	uc009xug.2	+	3	609	c.427G>C	c.(427-429)GAA>CAA	p.E143Q	CEP55_uc001kiq.3_Missense_Mutation_p.E143Q	NM_001127182	NP_001120654	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	143	Potential.				cell division|mitosis	centriole|cleavage furrow|midbody					0		Colorectal(252;0.207)				TGCTGAACTTGAAAGCAAAAC	0.383			NA											22	104					0	0	0.016522	0	0
CC2D2B	387707	broad.mit.edu	37	10	97779094	97779094	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:97779094T>C	uc001kll.2	+	7	856	c.657T>C	c.(655-657)AAT>AAC	p.N219N	uc001klg.1_Intron|uc001klj.1_Intron|CC2D2B_uc001klk.2_Intron|CC2D2B_uc010qop.1_Silent_p.N219N|uc009xvb.1_RNA	NM_001001732	NP_001001732	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B isoform	219										ovary(1)	1		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		ATGATAGAAATGTAAGTATAT	0.249			NA											15	97					0	0	0.020292	0	0
PDCD11	22984	broad.mit.edu	37	10	105194078	105194078	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:105194078C>G	uc001kwy.1	+	24	3725	c.3638C>G	c.(3637-3639)TCC>TGC	p.S1213C		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1213	S1 motif 10.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CCAGATTCCTCCAAGACCCTC	0.552			NA											9	211					0	0	0.006214	0	0
CALHM1	255022	broad.mit.edu	37	10	105218247	105218247	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:105218247G>T	uc001kxe.2	-	1	402	c.262C>A	c.(262-264)CGC>AGC	p.R88S		NM_001001412	NP_001001412	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	88						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			ovary(1)	1						TTGGCCCGGCGGCCCAGCGGC	0.662			NA											9	32					3.07112e-06	3.33023e-06	0.010729	1	0
COL17A1	1308	broad.mit.edu	37	10	105797421	105797421	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:105797421C>T	uc001kxr.2	-	46	3350	c.3181G>A	c.(3181-3183)GCA>ACA	p.A1061T		NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1061	Extracellular (Potential).|Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		ACGTGGCTTGCCAGCTCTGAG	0.592			NA											4	110					0	0	0.009096	0	0
C10orf79	80217	broad.mit.edu	37	10	105903388	105903388	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:105903388T>G	uc001kxw.2	-	32	4070	c.3954A>C	c.(3952-3954)AAA>AAC	p.K1318N	C10orf79_uc009xxq.2_Missense_Mutation_p.K597N	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	1318											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		GCGTTTTCTGTTTGGAAATCC	0.413			NA											13	43					0	0	0.013537	0	0
VTI1A	143187	broad.mit.edu	37	10	114428028	114428028	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:114428028T>A	uc001kzy.2	+	6	855	c.479T>A	c.(478-480)ATA>AAA	p.I160K	VTI1A_uc001kzz.2_Missense_Mutation_p.I160K	NM_145206	NP_660207	Q96AJ9	VTI1A_HUMAN	SNARE Vti1a-beta protein	160	Potential.				intracellular protein transport|retrograde transport, endosome to Golgi	SNARE complex	protein transporter activity|SNAP receptor activity			ovary(1)	1		Colorectal(252;0.0314)|Breast(234;0.183)		Epithelial(162;0.0126)|all cancers(201;0.0487)		AGAGAAAAGATACAGCGAGCA	0.358			NA											8	36					0	0	0.004482	0	0
TCF7L2	6934	broad.mit.edu	37	10	114925681	114925681	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:114925681G>T	uc001lae.3	+	14	2266	c.1759G>T	c.(1759-1761)GCC>TCC	p.A587S	TCF7L2_uc001lac.3_Missense_Mutation_p.A581S|TCF7L2_uc010qrk.1_3'UTR|TCF7L2_uc010qrl.1_Missense_Mutation_p.A564S|TCF7L2_uc010qrm.1_3'UTR|TCF7L2_uc010qrn.1_3'UTR|TCF7L2_uc001lad.3_3'UTR|TCF7L2_uc001lag.3_3'UTR|TCF7L2_uc001laf.3_Missense_Mutation_p.A564S|TCF7L2_uc010qro.1_3'UTR|TCF7L2_uc001lah.2_3'UTR|TCF7L2_uc010qrp.1_3'UTR|TCF7L2_uc010qrq.1_3'UTR|TCF7L2_uc010qrr.1_Missense_Mutation_p.A519S|TCF7L2_uc010qrs.1_Missense_Mutation_p.A475S|TCF7L2_uc010qrt.1_Missense_Mutation_p.A475S|TCF7L2_uc010qru.1_3'UTR|TCF7L2_uc010qrv.1_3'UTR|TCF7L2_uc010qrw.1_3'UTR|TCF7L2_uc010qrx.1_3'UTR	NM_001146274	NP_001139746	Q9NQB0	TF7L2_HUMAN	transcription factor 7-like 2 isoform 1	604					anti-apoptosis|blood vessel development|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell cycle arrest|cell proliferation|fat cell differentiation|glucose homeostasis|maintenance of DNA repeat elements|myoblast cell fate commitment|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|pancreas development|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of insulin secretion|positive regulation of protein binding|positive regulation of protein export from nucleus|positive regulation of protein kinase B signaling cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone metabolic process|regulation of smooth muscle cell proliferation|response to glucose stimulus	beta-catenin-TCF7L2 complex|PML body|protein-DNA complex	armadillo repeat domain binding|beta-catenin binding|gamma-catenin binding|nuclear hormone receptor binding|protein kinase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			large_intestine(3)|ovary(1)	4		Breast(234;0.058)|Colorectal(252;0.0615)		Epithelial(162;0.00554)|all cancers(201;0.02)		CAGCTCCCTGGCCGGGACCCA	0.587			NA											18	66					6.94344e-10	7.97022e-10	0.006122	1	0
ATRNL1	26033	broad.mit.edu	37	10	117040877	117040877	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:117040877T>A	uc001lcg.2	+	14	2499	c.2113T>A	c.(2113-2115)TAC>AAC	p.Y705N		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	705	PSI 2.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGTCAAGAACTACACCAAATG	0.284			NA											23	46					0	0	0.012319	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118203902	118203902	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:118203902A>G	uc001lcl.3	+	4	434	c.333A>G	c.(331-333)CTA>CTG	p.L111L		NM_001011709	NP_001011709	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3 precursor	111					lipid catabolic process	extracellular region	triglyceride lipase activity			ovary(1)	1				all cancers(201;0.0131)		AGGTGTTGCTACAGCTGGAAG	0.358			NA											10	37					0	0	0.008291	0	0
C10orf120	399814	broad.mit.edu	37	10	124457832	124457832	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:124457832A>T	uc001lgn.2	-	3	457	c.425T>A	c.(424-426)ATA>AAA	p.I142K		NM_001010912	NP_001010912	Q5SQS8	CJ120_HUMAN	hypothetical protein LOC399814	142										kidney(1)	1		all_neural(114;0.169)|Glioma(114;0.222)				TGCTGTCCATATTTTTTCTAG	0.458			NA											10	173					0	0	0.006214	0	0
MKI67	4288	broad.mit.edu	37	10	129907466	129907466	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:129907466C>A	uc001lke.2	-	13	2833	c.2638G>T	c.(2638-2640)GAG>TAG	p.E880*	MKI67_uc001lkf.2_Nonsense_Mutation_p.E520*|MKI67_uc009yav.1_Nonsense_Mutation_p.E455*|MKI67_uc009yaw.1_Nonsense_Mutation_p.E30*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	880					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTCCTGAACTCTGTAGACCTT	0.403			NA											58	180					6.25564e-26	8.29852e-26	0.01441	1	0
STK32C	282974	broad.mit.edu	37	10	134059451	134059451	+	Missense_Mutation	SNP	C	C	A	rs142282211		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:134059451C>A	uc001lle.1	-	2	411	c.271G>T	c.(271-273)GAC>TAC	p.D91Y	STK32C_uc001lld.1_5'UTR|STK32C_uc010quu.1_Missense_Mutation_p.D104Y|STK32C_uc009ybc.1_5'UTR|STK32C_uc009ybd.1_5'UTR|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	91							ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		TGGAAGTGGTCGAAGTTCACT	0.637			NA											22	59					2.98393e-07	3.30891e-07	0.016522	1	0
INPP5A	3632	broad.mit.edu	37	10	134459432	134459432	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr10:134459432A>C	uc001llp.2	+	3	426	c.178A>C	c.(178-180)AAC>CAC	p.N60H	INPP5A_uc001llo.1_Missense_Mutation_p.N60H|INPP5A_uc001llq.2_Missense_Mutation_p.N12H	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	60					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TGGAGGGAAGAACTACGAGGC	0.607	Pancreas(63;823 1267 11107 20380 51626)		NA											5	45					0	0	0.001168	0	0
OR51E1	143503	broad.mit.edu	37	11	4674113	4674113	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:4674113G>T	uc001lzi.3	+	2	501	c.357G>T	c.(355-357)CTG>CTT	p.L119L		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAGTGCTGCTGGCCATGGCTT	0.517			NA											23	93					2.89027e-11	3.377e-11	0.014323	1	0
HBD	3045	broad.mit.edu	37	11	5255426	5255426	+	Missense_Mutation	SNP	G	G	T	rs34383555		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:5255426G>T	uc001maf.1	-	2	305	c.110C>A	c.(109-111)CCT>CAT	p.P37H		NM_000519	NP_000510	P02042	HBD_HUMAN	delta globin	37					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTGGGTCCAAGGGTAGACCAC	0.517			NA											42	122					1.57019e-19	2.01808e-19	0.007835	1	0
OR56A4	120793	broad.mit.edu	37	11	6024118	6024118	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:6024118G>T	uc010qzv.1	-	1	261	c.261C>A	c.(259-261)AGC>AGA	p.S87R		NM_001005179	NP_001005179	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A,	35	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGAAGAGAAGGCTGAGGGGCA	0.592			NA											31	77					6.04164e-23	7.92082e-23	0.010818	1	0
OR52B2	255725	broad.mit.edu	37	11	6190952	6190952	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:6190952A>G	uc010qzy.1	-	1	605	c.605T>C	c.(604-606)TTC>TCC	p.F202S		NM_001004052	NP_001004052	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B,	202	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGGCACTGAGAAGCCATACCA	0.488	NSCLC(5;186 261 1778 7098 14207)		NA											9	40					0	0	0.013537	0	0
DCHS1	8642	broad.mit.edu	37	11	6661983	6661983	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:6661983C>A	uc001mem.1	-	2	1272	c.862G>T	c.(862-864)GGG>TGG	p.G288W		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	288	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCACAGCCCCATTGACACCA	0.592			NA											47	126					2.77807e-22	3.62397e-22	0.013114	1	0
MRPL17	63875	broad.mit.edu	37	11	6704014	6704014	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:6704014G>C	uc001men.2	-	2	312	c.207C>G	c.(205-207)AAC>AAG	p.N69K		NM_022061	NP_071344	Q9NRX2	RM17_HUMAN	mitochondrial ribosomal protein L17 precursor	69					translation	ribosome	protein domain specific binding|structural constituent of ribosome				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGGCTCGTTCGTTAGTGTCTC	0.512			NA											18	45					0	0	0.016522	0	0
OR6A2	8590	broad.mit.edu	37	11	6816486	6816486	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:6816486C>A	uc001mes.1	-	1	654	c.454G>T	c.(454-456)GGC>TGC	p.G152C		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCCCAAGAGCCAGCAGCCATC	0.502			NA											30	72					7.26314e-15	8.89735e-15	0.007291	1	0
OR10A3	26496	broad.mit.edu	37	11	7961052	7961052	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:7961052G>A	uc010rbi.1	-	1	16	c.16C>T	c.(16-18)CAA>TAA	p.Q6*		NM_001003745	NP_001003745	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACACAGCTTTGATTTTGTCTT	0.403			NA											45	85					0	0	0.009718	0	0
FSHB	2488	broad.mit.edu	37	11	30255202	30255202	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:30255202C>A	uc001msl.2	+	3	314	c.245C>A	c.(244-246)CCC>CAC	p.P82H	FSHB_uc001msm.2_Missense_Mutation_p.P82H|FSHB_uc001msn.2_Missense_Mutation_p.P82H	NM_000510	NP_000501	P01225	FSHB_HUMAN	follicle stimulating hormone, beta polypeptide	82					cellular nitrogen compound metabolic process|female gamete generation|female pregnancy|ovarian follicle development|peptide hormone processing|progesterone biosynthetic process|spermatogenesis|transforming growth factor beta receptor signaling pathway	cytoplasm|extracellular region|soluble fraction	follicle-stimulating hormone activity|protein heterodimerization activity			ovary(3)	3					Follitropin beta(DB00066)|Thyrotropin Alfa(DB00024)|Urofollitropin(DB00094)	GTGAGAGTGCCCGGCTGTGCT	0.502			NA											21	86					1.96292e-10	2.26313e-10	0.010504	1	0
DCDC1	341019	broad.mit.edu	37	11	31312213	31312214	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:31312213_31312214CC>AA	uc001msv.2	-	7	1142_1143	c.940_941GG>TT	c.(940-942)GGA>TTA	p.G314L	DCDC1_uc001msu.1_Intron	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	314					intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					TGTTTCTTTTCCCACTGTAATC	0.327			NA											24	62					0	0	0.004672	0	0
WT1	7490	broad.mit.edu	37	11	32413610	32413610	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:32413610C>A	uc001mtn.1	-	9	1536	c.1340G>T	c.(1339-1341)GGT>GTT	p.G447V	WT1_uc001mtl.1_Missense_Mutation_p.G235V|WT1_uc001mtm.1_Missense_Mutation_p.G218V|WT1_uc001mto.1_Missense_Mutation_p.G447V|WT1_uc001mtp.1_Missense_Mutation_p.G430V|WT1_uc001mtq.1_Missense_Mutation_p.G430V|WT1_uc009yjs.1_RNA	NM_024426	NP_077744	P19544	WT1_HUMAN	Wilms tumor 1 isoform D	379	Important for interaction with target DNA.		G -> C (in NPHS4).		adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.G379V(2)|p.V380_S410del(1)	EWSR1/WT1(231)	haematopoietic_and_lymphoid_tissue(318)|soft_tissue(231)|kidney(132)|pleura(2)|lung(2)|upper_aerodigestive_tract(1)|peritoneum(1)	687	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TGGTTTCACACCTAAATGGAC	0.532			NA	D|Mis|N|F|S	EWSR1	Wilms|desmoplastic small round cell tumor	Wilms			Denys-Drash_syndrome|Frasier_syndrome|Familial_Wilms_tumor|Wilms_tumor-Aniridia-ambiguous_Genitals-mental_Retardation				120	218					3.84086e-47	5.38682e-47	0.01441	1	0
C11orf41	25758	broad.mit.edu	37	11	33628193	33628193	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:33628193C>T	uc001mup.3	+	13	4137	c.4013C>T	c.(4012-4014)GCG>GTG	p.A1338V		NM_012194	NP_036326	Q6ZVL6	CK041_HUMAN	hypothetical protein LOC25758	1332						integral to membrane				ovary(2)	2						TCAGTGCCAGCGAGTGACGAA	0.483			NA											7	85					0	0	0.008291	0	0
SLC1A2	6506	broad.mit.edu	37	11	35333830	35333830	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:35333830T>C	uc001mwd.2	-	4	1068	c.476A>G	c.(475-477)AAT>AGT	p.N159S	SLC1A2_uc001mwe.2_Missense_Mutation_p.N150S|SLC1A2_uc010rev.1_Missense_Mutation_p.N159S	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	159	Extracellular (Potential).				D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	CACTTCATCATTCTTCTTCCC	0.512	NSCLC(100;1273 1575 12993 16869 47409)|Ovarian(164;45 1946 8965 30452 48454)		NA											48	399					0	0	0.01441	0	0
EXT2	2132	broad.mit.edu	37	11	44097136	44097136	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:44097136G>C	uc010rfo.1	+	1	61	c.48G>C	c.(46-48)AGG>AGC	p.R16S	ACCS_uc010rfm.1_Missense_Mutation_p.A111P|ACCS_uc009yks.1_Missense_Mutation_p.A184P|ACCS_uc010rfn.1_3'UTR|ACCS_uc001mxx.2_Missense_Mutation_p.A184P	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GCTGTGTGAGGCCGGGGGTAA	0.577			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				15	137					0	0	0.020292	0	0
MADD	8567	broad.mit.edu	37	11	47314115	47314115	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:47314115A>C	uc001ner.1	+	21	3574	c.3383A>C	c.(3382-3384)GAA>GCA	p.E1128A	MADD_uc001neq.2_Intron|MADD_uc001nev.1_Intron|MADD_uc001nes.1_Intron|MADD_uc001net.1_Intron|MADD_uc009yln.1_Intron|MADD_uc001neu.1_Intron|MADD_uc001nex.2_Missense_Mutation_p.E1128A|MADD_uc001nez.2_Intron|MADD_uc001new.2_Intron|MADD_uc009ylo.2_Missense_Mutation_p.E46A	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1128					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		AAGCACCAGGAAGTGAAAAAG	0.493			NA											16	101					0	0	0.006122	0	0
OR4C3	256144	broad.mit.edu	37	11	48346726	48346726	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:48346726C>T	uc010rhv.1	+	1	234	c.234C>T	c.(232-234)CCC>CCT	p.P78P		NM_001004702	NP_001004702	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						CCTCCAGCCCCACGCTGGCTT	0.453			NA											13	197					0	0	0.013537	0	0
OR4A15	81328	broad.mit.edu	37	11	55136184	55136184	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:55136184C>A	uc010rif.1	+	1	825	c.825C>A	c.(823-825)GTC>GTA	p.V275V		NM_001005275	NP_001005275	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A,	275	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TCACTGTGGTCATTTTATTCT	0.408			NA											104	202					4.98208e-43	6.92544e-43	0.01441	1	0
OR8K5	219453	broad.mit.edu	37	11	55927514	55927514	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:55927514A>T	uc010rja.1	-	1	280	c.280T>A	c.(280-282)TAT>AAT	p.Y94N		NM_001004058	NP_001004058	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				CATGCATAATAGGAAATAGTA	0.403			NA											33	115					0	0	0.015359	0	0
OR5M1	390168	broad.mit.edu	37	11	56380147	56380147	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:56380147A>T	uc001nja.1	-	1	832	c.832T>A	c.(832-834)TAT>AAT	p.Y278N		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						AAAAAAGTATAAAAGACTGCA	0.413			NA											139	242					0	0	0.01441	0	0
FAM111B	374393	broad.mit.edu	37	11	58891882	58891882	+	Missense_Mutation	SNP	C	C	A	rs150852006		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:58891882C>A	uc001nnl.2	+	4	555	c.312C>A	c.(310-312)AGC>AGA	p.S104R	FAM111B_uc001nnm.2_Missense_Mutation_p.S74R|FAM111B_uc010rko.1_Missense_Mutation_p.S74R	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	104				S -> G (in Ref. 3; AAH62456).			catalytic activity			ovary(2)	2						GTAAACCCAGCGAGAGTATCT	0.338			NA											35	85					2.47316e-13	2.97843e-13	0.015359	1	0
OR5A2	219981	broad.mit.edu	37	11	59190132	59190132	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:59190132C>G	uc010rkt.1	-	1	295	c.295G>C	c.(295-297)GCC>CCC	p.A99P		NM_001001954	NP_001001954	Q8NGI9	OR5A2_HUMAN	olfactory receptor, family 5, subfamily A,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACTGAGTGGCACAGCCAACA	0.512			NA											43	74					0	0	0.010771	0	0
MS4A7	58475	broad.mit.edu	37	11	60150636	60150636	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:60150636A>G	uc001npe.2	+	2	167	c.22A>G	c.(22-24)ATG>GTG	p.M8V	MS4A7_uc001npf.2_Missense_Mutation_p.M8V|MS4A7_uc001npg.2_Missense_Mutation_p.M8V|MS4A7_uc001nph.2_Missense_Mutation_p.M8V|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Missense_Mutation_p.M8V	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	8	Cytoplasmic (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						ATCCCAAACCATGGGGGTTTC	0.453			NA											58	107					0	0	0.01441	0	0
MS4A5	64232	broad.mit.edu	37	11	60198329	60198329	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:60198329T>A	uc001npo.2	+	2	300	c.214T>A	c.(214-216)TTG>ATG	p.L72M		NM_023945	NP_076434	Q9H3V2	MS4A5_HUMAN	membrane-spanning 4-domains, subfamily A, member	72	Helical; (Potential).					integral to membrane	receptor activity			large_intestine(1)|ovary(1)	2						CCTTTTCACCTTGTTAAAACC	0.368			NA											64	185					0	0	0.01441	0	0
DDB1	1642	broad.mit.edu	37	11	61077340	61077340	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:61077340C>T	uc001nrc.3	-	20	2720	c.2494G>A	c.(2494-2496)GGC>AGC	p.G832S	DDB1_uc010rle.1_Missense_Mutation_p.G143S|DDB1_uc010rlf.1_Missense_Mutation_p.G832S	NM_001923	NP_001914	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1	832	Interaction with CDT1 and CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			ovary(2)|lung(1)|central_nervous_system(1)	4						ATTGCTGTGCCCACAATGAAG	0.512			NA						NER					30	134					0	0	0.00632	0	0
AHNAK	79026	broad.mit.edu	37	11	62292744	62292744	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:62292744C>T	uc001ntl.2	-	5	9445	c.9145G>A	c.(9145-9147)GCT>ACT	p.A3049T	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	3049					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCAAGGTCAGCCTTGGGCAGG	0.498			NA											15	423					0	0	0.020292	0	0
KRTAP5-11	440051	broad.mit.edu	37	11	71293630	71293630	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:71293630G>A	uc001oqu.2	-	1	292	c.254C>T	c.(253-255)TCC>TTC	p.S85F		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	85	6 X 4 AA repeats of C-C-X-P.					keratin filament					0						ACAGCAGTTGGACTGGGAGCA	0.358			NA											40	106					0	0	0.005524	0	0
C2CD3	26005	broad.mit.edu	37	11	73825446	73825446	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:73825446C>T	uc001ouu.2	-	10	1940	c.1713G>A	c.(1711-1713)GTG>GTA	p.V571V	C2CD3_uc001ouv.2_Silent_p.V571V	NM_015531	NP_056346	Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	571						centrosome				ovary(4)|pancreas(2)|skin(1)	7	Breast(11;4.16e-06)					TTGCTGTAGTCACCTTAGGTG	0.408			NA											6	54					0	0	0.001984	0	0
NARS2	79731	broad.mit.edu	37	11	78204159	78204159	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:78204159T>C	uc001ozi.2	-	7	1148	c.772A>G	c.(772-774)ATG>GTG	p.M258V	NARS2_uc010rsq.1_Missense_Mutation_p.M31V	NM_024678	NP_078954	Q96I59	SYNM_HUMAN	asparaginyl-tRNA synthetase 2, mitochondrial	258					asparaginyl-tRNA aminoacylation	mitochondrial matrix	asparagine-tRNA ligase activity|ATP binding|nucleic acid binding			ovary(2)	2	all_cancers(14;2.63e-17)|all_epithelial(13;1.85e-19)				L-Asparagine(DB00174)	GCTTCTATCATATAAAACTCT	0.393			NA											57	80					0	0	0.01441	0	0
DLG2	1740	broad.mit.edu	37	11	83173087	83173087	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:83173087G>C	uc001paj.2	-	22	2767	c.2464C>G	c.(2464-2466)CGA>GGA	p.R822G	DLG2_uc001pai.2_Missense_Mutation_p.R701G|DLG2_uc010rsy.1_Missense_Mutation_p.R771G|DLG2_uc010rsz.1_Missense_Mutation_p.R818G|DLG2_uc010rta.1_Missense_Mutation_p.R804G|DLG2_uc001pak.2_Missense_Mutation_p.R927G|DLG2_uc010rtb.1_Missense_Mutation_p.R789G|DLG2_uc010rsw.1_Missense_Mutation_p.R286G|DLG2_uc010rsx.1_Missense_Mutation_p.R299G	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	822	Guanylate kinase-like.					cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TTAATTGCTCGATCATAGGTT	0.378			NA											16	91					0	0	0.006122	0	0
CCDC67	159989	broad.mit.edu	37	11	93118676	93118676	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:93118676G>C	uc001pdq.2	+	8	1002	c.902G>C	c.(901-903)GGA>GCA	p.G301A	CCDC67_uc001pdo.1_Missense_Mutation_p.G301A|CCDC67_uc001pdp.2_Missense_Mutation_p.G301A	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	301										ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TTAAAAATAGGAGAGTGCCAA	0.323			NA											12	36					0	0	0.010729	0	0
PIWIL4	143689	broad.mit.edu	37	11	94322291	94322291	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:94322291A>G	uc001pfa.2	+	8	1130	c.919A>G	c.(919-921)AAT>GAT	p.N307D	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	307	PAZ.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TGGCAGATACAATAACAGAAC	0.378			NA											19	76					0	0	0.006122	0	0
CWF19L2	143884	broad.mit.edu	37	11	107207336	107207336	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:107207336T>G	uc010rvp.1	-	15	2336	c.2306A>C	c.(2305-2307)GAA>GCA	p.E769A	CWF19L2_uc001pjh.3_RNA|CWF19L2_uc009yxo.2_RNA	NM_152434	NP_689647	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control	769							catalytic activity				0		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		AGGAATACATTCATAAACCAT	0.333			NA											27	70					0	0	0.009535	0	0
NPAT	4863	broad.mit.edu	37	11	108040747	108040747	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:108040747G>C	uc001pjz.3	-	14	2911	c.2809C>G	c.(2809-2811)CCA>GCA	p.P937A	NPAT_uc010rvv.1_5'UTR	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	937					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		GGCTGGACTGGAGAGGCAATT	0.383			NA											108	116					0	0	0.01441	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110035851	110035851	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:110035851C>T	uc009yxw.2	+	6	2092	c.2041C>T	c.(2041-2043)CAC>TAC	p.H681Y	ZC3H12C_uc010rwc.1_Missense_Mutation_p.H682Y|ZC3H12C_uc010rwd.1_Missense_Mutation_p.H682Y|ZC3H12C_uc001pkr.3_Missense_Mutation_p.H650Y	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	681							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		GCAGAATTTCCACGACCCCTT	0.547			NA											71	484					0	0	0.01441	0	0
FAM55D	54827	broad.mit.edu	37	11	114453150	114453150	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:114453150G>C	uc001ppc.2	-	3	871	c.690C>G	c.(688-690)TGC>TGG	p.C230W	FAM55D_uc001ppd.2_Intron	NM_001077639	NP_001071107	Q6UWF7	FA55D_HUMAN	hypothetical protein LOC54827 isoform 1	230						extracellular region				ovary(2)|skin(2)	4		all_cancers(61;8.53e-16)|all_epithelial(67;1.71e-08)|all_hematologic(158;3.05e-05)|Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0194)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0906)		BRCA - Breast invasive adenocarcinoma(274;2.82e-06)|Epithelial(105;0.000129)|all cancers(92;0.000938)		CCAGGTACTGGCACAATTCAG	0.478			NA											23	211					0	0	0.016522	0	0
DSCAML1	57453	broad.mit.edu	37	11	117308768	117308768	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:117308768G>T	uc001prh.1	-	25	4457	c.4455C>A	c.(4453-4455)AGC>AGA	p.S1485R		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1425	Fibronectin type-III 5.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TCCACTCCTCGCTGTTGTCCA	0.602			NA											44	39					4.1673e-28	5.56587e-28	0.01441	1	0
IL10RA	3587	broad.mit.edu	37	11	117870171	117870171	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:117870171C>A	uc001prv.2	+	7	1629	c.1552C>A	c.(1552-1554)CAG>AAG	p.Q518K	IL10RA_uc010rxl.1_Missense_Mutation_p.Q498K|IL10RA_uc010rxm.1_Missense_Mutation_p.Q498K|IL10RA_uc010rxn.1_Missense_Mutation_p.Q369K|IL10RA_uc001prw.2_Missense_Mutation_p.Q369K	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	518	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		ACAGTGGAACCAGCCCACTGA	0.577			NA											59	69					2.47907e-22	3.23931e-22	0.01441	1	0
FOXR1	283150	broad.mit.edu	37	11	118851198	118851198	+	Splice_Site	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:118851198A>G	uc001pui.2	+	5	837	c.612_splice	c.e5-2	p.R204_splice	FOXR1_uc001puj.2_Intron|FOXR1_uc001puk.2_Splice_Site_p.R35_splice	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1						embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CCCTGTCCATAGAAAGCACTT	0.537			NA											82	117					0	0	0.01441	0	0
DPAGT1	1798	broad.mit.edu	37	11	118971090	118971090	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:118971090C>A	uc001pvi.2	-	4	945	c.525G>T	c.(523-525)CTG>CTT	p.L175L	DPAGT1_uc001pvj.2_Silent_p.L68L|DPAGT1_uc009zaq.2_RNA|DPAGT1_uc001pvk.2_Silent_p.L3L|DPAGT1_uc010ryz.1_Silent_p.L175L|DPAGT1_uc001pvm.1_Silent_p.L68L|DPAGT1_uc010rza.1_Silent_p.L68L	NM_001382	NP_001373	Q9H3H5	GPT_HUMAN	UDP-N-acetylglucosamine-dolichyl-phosphate	175	Helical; (Potential).				dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|ovary(1)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		ACACTGCCAGCAGCCCCATGT	0.463			NA									OREG0021396	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	195					1.19403e-26	1.58665e-26	0.01441	1	0
POU2F3	25833	broad.mit.edu	37	11	120175882	120175882	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:120175882G>A	uc001pxc.2	+	7	690	c.588G>A	c.(586-588)AAG>AAA	p.K196K	POU2F3_uc010rzk.1_Silent_p.K150K|POU2F3_uc010rzl.1_Silent_p.K126K|POU2F3_uc001pxe.1_5'Flank	NM_014352	NP_055167	Q9UKI9	PO2F3_HUMAN	POU transcription factor	196	POU-specific.				negative regulation by host of viral transcription	cytoplasm	sequence-specific DNA binding			ovary(1)|skin(1)	2		Breast(109;0.0011)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;6.85e-06)		AGTTTGCCAAGACCTTCAAGC	0.567			NA											30	233					0	0	0.008361	0	0
HSPA8	3312	broad.mit.edu	37	11	122930824	122930824	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:122930824C>T	uc001pyo.2	-	4	642	c.564G>A	c.(562-564)AAG>AAA	p.K188K	HSPA8_uc009zbc.2_5'UTR|HSPA8_uc001pyp.2_Silent_p.K188K|HSPA8_uc010rzu.1_Silent_p.K111K|HSPA8_uc009zbd.1_Silent_p.K188K|HSPA8_uc010rzv.1_Silent_p.K188K	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	188	Interaction with BAG1.				cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGTACATACCTTTTTGTCTA	0.368	Colon(21;486 594 5900 6733 14272)		NA											18	192					0	0	0.007413	0	0
OR10G4	390264	broad.mit.edu	37	11	123887150	123887150	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:123887150G>A	uc010sac.1	+	1	869	c.869G>A	c.(868-870)AGA>AAA	p.R290K		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	290	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TACACCCTGAGAAACAAGGAG	0.433			NA											80	110					0	0	0.01441	0	0
FEZ1	9638	broad.mit.edu	37	11	125325834	125325834	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:125325834T>A	uc001qbx.2	-	6	988	c.836A>T	c.(835-837)AAC>ATC	p.N279I	FEZ1_uc001qbw.2_Missense_Mutation_p.N69I|FEZ1_uc010sbc.1_Missense_Mutation_p.N250I	NM_005103	NP_005094	Q99689	FEZ1_HUMAN	zygin 1 isoform 1	279	Potential.				axon guidance|cell adhesion|transport	microtubule|plasma membrane				central_nervous_system(3)|ovary(1)	4	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		CTTCTGCTTGTTCTGAACCTC	0.542	Melanoma(180;509 2033 10762 15939 24711)		NA											9	265					0	0	0.006214	0	0
KCNJ1	3758	broad.mit.edu	37	11	128710054	128710054	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:128710054T>A	uc001qeo.1	-	2	193	c.142A>T	c.(142-144)AGG>TGG	p.R48W	KCNJ1_uc001qep.1_Missense_Mutation_p.R29W|KCNJ1_uc001qeq.1_Missense_Mutation_p.R29W|KCNJ1_uc001qer.1_Missense_Mutation_p.R29W|KCNJ1_uc001qes.1_Missense_Mutation_p.R29W	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	48	Cytoplasmic (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	ATGTTGCACCTTCCATCTTTG	0.438			NA											10	293					0	0	0.006214	0	0
ST14	6768	broad.mit.edu	37	11	130058061	130058061	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:130058061A>G	uc001qfw.2	+	2	327	c.134A>G	c.(133-135)AAG>AGG	p.K45R	ST14_uc010sca.1_5'Flank	NM_021978	NP_068813	Q9Y5Y6	ST14_HUMAN	matriptase	45	Cytoplasmic (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(2)|skin(2)|central_nervous_system(1)	5	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	AACAACGTCAAGAAGGTGGAA	0.617			NA											36	51					0	0	0.01441	0	0
OPCML	4978	broad.mit.edu	37	11	132307138	132307138	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:132307138C>T	uc001qgs.2	-	4	692	c.642G>A	c.(640-642)CGG>CGA	p.R214R	OPCML_uc001qgu.2_Silent_p.R207R|OPCML_uc010sck.1_Silent_p.R214R|OPCML_uc001qgt.2_Silent_p.R213R|OPCML_uc010scl.1_Silent_p.R173R	NM_002545	NP_002536	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion	214	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			ovary(2)|skin(1)	3	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		TTTTTACTTTCCGCACATCGG	0.542			NA											6	279					0	0	0.001984	0	0
GLB1L2	89944	broad.mit.edu	37	11	134240907	134240907	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:134240907C>G	uc001qhp.2	+	13	1409	c.1221C>G	c.(1219-1221)ATC>ATG	p.I407M	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	407					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		CGCAGCCAATCAAGTCTGAAA	0.567			NA											53	309					0	0	0.01441	0	0
WNK1	65125	broad.mit.edu	37	12	970256	970256	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:970256G>C	uc001qio.3	+	7	2205	c.1698G>C	c.(1696-1698)AAG>AAC	p.K566N	WNK1_uc001qip.3_Missense_Mutation_p.K566N|WNK1_uc001qir.3_Missense_Mutation_p.K13N	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	566					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CATTAATTAAGAGGAAACGAG	0.433	Colon(19;451 567 6672 12618 28860)		NA											78	323					0	0	0.01441	0	0
PZP	5858	broad.mit.edu	37	12	9344799	9344799	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:9344799C>A	uc001qvl.2	-	13	1565	c.1536G>T	c.(1534-1536)GAG>GAT	p.E512D	PZP_uc009zgl.2_Missense_Mutation_p.E381D	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TGTCTCCTGACTCCACAGGCA	0.463	Melanoma(125;1402 1695 4685 34487 38571)		NA											17	34					1.67942e-08	1.89176e-08	0.006122	1	0
DDX12	440081	broad.mit.edu	37	12	9573997	9573997	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:9573997T>G	uc010sgs.1	-	20	2234	c.2039A>C	c.(2038-2040)GAC>GCC	p.D680A	DDX12_uc001qvx.3_5'Flank|DDX12_uc001qvy.1_5'Flank	NM_004400	NP_004391			DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12												0						CTGAGGCAGGTCTCTCTTCTG	0.617			NA											7	12					0	0	0.008361	0	0
CLEC7A	64581	broad.mit.edu	37	12	10280406	10280406	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:10280406C>T	uc001qxg.2	-	2	329	c.142G>A	c.(142-144)GTA>ATA	p.V48I	CLEC7A_uc001qxe.3_RNA|CLEC7A_uc001qxf.2_Missense_Mutation_p.V48I|CLEC7A_uc001qxh.2_Missense_Mutation_p.V48I|CLEC7A_uc001qxi.2_Missense_Mutation_p.V48I|CLEC7A_uc001qxj.2_Intron|CLEC7A_uc009zhg.1_Intron|CLEC7A_uc001qxk.1_RNA|CLEC7A_uc001qxl.1_Missense_Mutation_p.V48I|CLEC7A_uc010sgy.1_Missense_Mutation_p.V48I|CLEC7A_uc001qxm.1_Missense_Mutation_p.V48I|CLEC7A_uc001qxn.2_Missense_Mutation_p.V48I	NM_197947	NP_922938	Q9BXN2	CLC7A_HUMAN	dendritic cell-associated C-type lectin 1	48	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)	1						CCCAAAATTACAGCAATGAGG	0.458			NA											4	4					0	0	0.009096	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21068974	21068974	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:21068974C>G	uc001rek.2	+	15	2028	c.1902C>G	c.(1900-1902)TTC>TTG	p.F634L	SLCO1B3_uc001rel.2_Missense_Mutation_p.F634L|SLCO1B3_uc010sil.1_Intron|LST-3TM12_uc010sim.1_Intron	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	634	Helical; Name=12; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					CTTTAAGATTCCCAGCACTTG	0.294			NA											5	172					0	0	0.001168	0	0
SLCO1B1	10599	broad.mit.edu	37	12	21349976	21349976	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:21349976C>A	uc001req.3	+	8	928	c.824C>A	c.(823-825)CCA>CAA	p.P275Q		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	275	Helical; Name=6; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TCTTCCATACCATTCTTTTTC	0.393			NA											19	332					1.56452e-12	1.86695e-12	0.007413	1	0
SLCO1B1	10599	broad.mit.edu	37	12	21350017	21350017	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:21350017G>A	uc001req.3	+	8	969	c.865G>A	c.(865-867)GAA>AAA	p.E289K		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	289	Cytoplasmic (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	ACCACAAAAAGAAAGAAAAGC	0.353			NA											12	276					0	0	0.020292	0	0
ETNK1	55500	broad.mit.edu	37	12	22824222	22824222	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:22824222T>C	uc001rft.2	+	5	1006	c.984T>C	c.(982-984)ATT>ATC	p.I328I	ETNK1_uc009ziz.2_Silent_p.I328I	NM_018638	NP_061108	Q9HBU6	EKI1_HUMAN	ethanolamine kinase 1 isoform A	328					phosphatidylethanolamine biosynthetic process	cytoplasm	ATP binding|ethanolamine kinase activity				0						TACAGTTCATTGATTATGAAT	0.299	Esophageal Squamous(42;87 913 3224 6226 43339)		NA											8	701					0	0	0.006214	0	0
C12orf11	55726	broad.mit.edu	37	12	27066454	27066454	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:27066454C>T	uc001rhk.3	-	14	2278	c.1741G>A	c.(1741-1743)GAG>AAG	p.E581K	C12orf11_uc001rhj.3_Missense_Mutation_p.E149K|C12orf11_uc010sjk.1_Missense_Mutation_p.E480K	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	581	Potential.				cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					GACTTGTCCTCTTTGTCTTCC	0.453			NA											243	679					0	0	0.01441	0	0
C12orf11	55726	broad.mit.edu	37	12	27067485	27067485	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:27067485G>C	uc001rhk.3	-	12	1812	c.1275C>G	c.(1273-1275)AAC>AAG	p.N425K	C12orf11_uc001rhj.3_Intron|C12orf11_uc010sjk.1_Missense_Mutation_p.N324K	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	425					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					GAGTTAATCTGTTTTCCCTCA	0.338			NA											12	401					0	0	0.013537	0	0
C12orf11	55726	broad.mit.edu	37	12	27078748	27078748	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:27078748G>A	uc001rhk.3	-	6	1158	c.621C>T	c.(619-621)ATC>ATT	p.I207I	C12orf11_uc010sjk.1_Silent_p.I106I	NM_018164	NP_060634	Q9NVM9	M89BB_HUMAN	hypothetical protein LOC55726	207					cell division|mitosis|regulation of mitotic cell cycle		protein binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	Colorectal(261;0.0847)					GGTAGGTGTGGATCAAGACCA	0.323			NA											256	551					0	0	0.01441	0	0
FAR2	55711	broad.mit.edu	37	12	29486613	29486613	+	Silent	SNP	C	C	T	rs142204438	by1000genomes	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:29486613C>T	uc001ris.3	+	12	1581	c.1434C>T	c.(1432-1434)GCC>GCT	p.A478A	FAR2_uc001rit.2_Silent_p.A478A|FAR2_uc009zjm.2_Silent_p.A381A	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	478	Helical; (Potential).				ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						TCCTTATCGCCTGGCGCCTTC	0.438			NA											39	178					0	0	0.00623	0	0
FGD4	121512	broad.mit.edu	37	12	32735077	32735077	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:32735077T>C	uc001rkz.2	+	4	753	c.276T>C	c.(274-276)GGT>GGC	p.G92G	FGD4_uc001rlc.2_Silent_p.G177G|FGD4_uc001rky.2_5'UTR|FGD4_uc001rla.2_5'UTR|FGD4_uc010ske.1_Silent_p.G204G|FGD4_uc001rlb.1_RNA|FGD4_uc001rkx.3_Silent_p.G92G	NM_139241	NP_640334	Q96M96	FGD4_HUMAN	FYVE, RhoGEF and PH domain containing 4	92	Actin filament-binding (By similarity).				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|filopodium|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)					TGGCCAACGGTGTAATGGCAG	0.488			NA											13	541					0	0	0.003163	0	0
KIF21A	55605	broad.mit.edu	37	12	39701384	39701384	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:39701384C>G	uc001rly.2	-	34	4571	c.4425G>C	c.(4423-4425)AGG>AGC	p.R1475S	KIF21A_uc001rlv.2_Missense_Mutation_p.R420S|KIF21A_uc001rlw.2_Missense_Mutation_p.R745S|KIF21A_uc001rlx.2_Missense_Mutation_p.R1462S|KIF21A_uc001rlz.2_Missense_Mutation_p.R1422S|KIF21A_uc010skl.1_Missense_Mutation_p.R1438S|KIF21A_uc001rlt.2_Missense_Mutation_p.R95S|KIF21A_uc001rlu.2_Missense_Mutation_p.R95S	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1475	WD 3.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				GATCCCACATCCTGACAGCAT	0.398			NA											10	122					0	0	0.006214	0	0
KIF21A	55605	broad.mit.edu	37	12	39716581	39716581	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:39716581G>A	uc001rly.2	-	27	3706	c.3560C>T	c.(3559-3561)ACA>ATA	p.T1187I	KIF21A_uc001rlv.2_Missense_Mutation_p.T192I|KIF21A_uc001rlw.2_Missense_Mutation_p.T504I|KIF21A_uc001rlx.2_Missense_Mutation_p.T1174I|KIF21A_uc001rlz.2_Missense_Mutation_p.T1151I|KIF21A_uc010skl.1_Missense_Mutation_p.T1167I	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1187					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TGCAACAGGTGTGAGAGGGCC	0.498			NA											55	337					0	0	0.01441	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43856734	43856734	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:43856734C>T	uc010skx.1	-	11	1578	c.1578G>A	c.(1576-1578)GTG>GTA	p.V526V		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	526	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGCTGGTGGCACGTGTTGAG	0.463			NA											4	16					0	0	0.014758	0	0
DBX2	440097	broad.mit.edu	37	12	45410296	45410296	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:45410296G>T	uc001rok.1	-	4	965	c.793C>A	c.(793-795)CTC>ATC	p.L265I		NM_001004329	NP_001004329	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	265						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		GACCGTGAGAGGGGATCCTCT	0.483			NA											49	122					4.86159e-25	6.40586e-25	0.01441	1	0
AMIGO2	347902	broad.mit.edu	37	12	47471976	47471976	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:47471976A>G	uc001rpm.2	-	3	1465	c.810T>C	c.(808-810)CGT>CGC	p.R270R	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Silent_p.R270R|AMIGO2_uc001rpl.2_Silent_p.R270R	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	270	Extracellular (Potential).|LRRCT.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					GAAGTACCTGACGCGAGTGCC	0.493			NA											8	120					0	0	0.00308	0	0
TMEM106C	79022	broad.mit.edu	37	12	48358151	48358151	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:48358151C>T	uc001rqp.2	+	2	247	c.132C>T	c.(130-132)ACC>ACT	p.T44T	TMEM106C_uc001rqo.2_Silent_p.T44T|TMEM106C_uc001rqr.2_Silent_p.T44T|TMEM106C_uc001rqq.2_Silent_p.T44T	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	44						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TGGAATTCACCGGGAGAGATA	0.537			NA											18	38					0	0	0.007413	0	0
COL2A1	1280	broad.mit.edu	37	12	48376677	48376677	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:48376677T>C	uc001rqu.2	-	33	2328	c.2147A>G	c.(2146-2148)CAG>CGG	p.Q716R	COL2A1_uc009zkw.2_RNA|COL2A1_uc001rqv.2_Missense_Mutation_p.Q647R	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	716	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	ACGGGGACCCTGGAGGCCCTG	0.627			NA											67	97					0	0	0.01441	0	0
WNT10B	7480	broad.mit.edu	37	12	49362003	49362003	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:49362003C>A	uc001rss.2	-	4	783	c.437G>T	c.(436-438)TGT>TTT	p.C146F	WNT10B_uc001rst.2_Missense_Mutation_p.C146F	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	146					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						CTTCCAGCCACAGCCACAGCT	0.597			NA											20	45					5.35047e-06	5.77792e-06	0.01892	1	0
TROAP	10024	broad.mit.edu	37	12	49719372	49719372	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:49719372G>T	uc001rtx.3	+	4	593	c.426G>T	c.(424-426)GGG>GGT	p.G142G	TROAP_uc009zlh.2_Silent_p.G142G|TROAP_uc001rty.2_5'Flank	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	142					cell adhesion	cytoplasm				ovary(1)	1						GTCACCTGGGGCGCCAGCCTA	0.582			NA											21	92					1.96292e-10	2.26313e-10	0.010504	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54925558	54925558	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:54925558C>G	uc001sgc.3	+	25	2809	c.2730C>G	c.(2728-2730)ATC>ATG	p.I910M	NCKAP1L_uc010sox.1_Missense_Mutation_p.I452M|NCKAP1L_uc010soy.1_Missense_Mutation_p.I860M	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	910					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GCATGACCATCATTGGGGTTA	0.488			NA											31	90					0	0	0.015359	0	0
SLC35E3	55508	broad.mit.edu	37	12	69140237	69140237	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:69140237G>T	uc001suh.2	+	1	302	c.80G>T	c.(79-81)TGC>TTC	p.C27F		NM_018656	NP_061126	Q7Z769	S35E3_HUMAN	solute carrier family 35, member E2	27	Helical; (Potential).					integral to membrane					0	Breast(13;2.31e-06)|Renal(347;0.0684)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00372)			GTGTCCATCTGCATTGTGTTC	0.592			NA											25	56					3.28513e-13	3.95021e-13	0.021523	1	0
KCNC2	3747	broad.mit.edu	37	12	75444633	75444633	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:75444633C>A	uc001sxg.1	-	3	1696	c.1152G>T	c.(1150-1152)CTG>CTT	p.L384L	KCNC2_uc009zry.2_Silent_p.L384L|KCNC2_uc001sxe.2_Silent_p.L384L|KCNC2_uc001sxf.2_Silent_p.L384L|KCNC2_uc010stw.1_Silent_p.L384L	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	384	Helical; Name=Segment S5; (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AAATTATCAGCAGCAAAAATT	0.453			NA											18	73					2.5808e-16	3.20657e-16	0.006122	1	0
OSBPL8	114882	broad.mit.edu	37	12	76786490	76786490	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:76786490G>A	uc001sye.1	-	10	1280	c.800C>T	c.(799-801)TCT>TTT	p.S267F	OSBPL8_uc001syf.1_Missense_Mutation_p.S225F|OSBPL8_uc001syg.1_Missense_Mutation_p.S225F|OSBPL8_uc001syh.1_Missense_Mutation_p.S242F	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	267					lipid transport		lipid binding			ovary(1)	1						AAGAAGACTAGAACATTTCAA	0.383			NA											15	66					0	0	0.003163	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373677	86373677	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:86373677A>G	uc001tai.3	-	8	2077	c.827T>C	c.(826-828)TTA>TCA	p.L276S	MGAT4C_uc001tal.3_Missense_Mutation_p.L276S|MGAT4C_uc001taj.3_Missense_Mutation_p.L276S|MGAT4C_uc001tak.3_Missense_Mutation_p.L276S|MGAT4C_uc010sum.1_Missense_Mutation_p.L300S|MGAT4C_uc001tah.3_Missense_Mutation_p.L276S	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	276	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						AAACATTAATAAAAAATGGGC	0.383			NA											24	51					0	0	0.016522	0	0
SLC5A8	160728	broad.mit.edu	37	12	101576622	101576622	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:101576622G>A	uc001thz.3	-	9	1514	c.1124C>T	c.(1123-1125)TCG>TTG	p.S375L		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	375	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						TTCTGAGAGCGATCTGAAGTA	0.368	GBM(60;420 1056 13605 22380 47675)		NA											14	64					0	0	0.004007	0	0
STAB2	55576	broad.mit.edu	37	12	104098343	104098343	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:104098343G>A	uc001tjw.2	+	36	4037	c.3851G>A	c.(3850-3852)TGT>TAT	p.C1284Y		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1284	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AAGGGAAGATGTAGGACATGC	0.373			NA											18	37					0	0	0.00499	0	0
KIAA1033	23325	broad.mit.edu	37	12	105538144	105538144	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:105538144G>T	uc001tld.2	+	21	2177	c.2090G>T	c.(2089-2091)CGA>CTA	p.R697L	KIAA1033_uc010swr.1_Missense_Mutation_p.R698L|KIAA1033_uc010sws.1_Missense_Mutation_p.R509L	NM_015275	NP_056090	Q2M389	WAHS7_HUMAN	hypothetical protein LOC23325	697					endosome transport	WASH complex				kidney(1)|central_nervous_system(1)	2						CTGGATGACCGAAACCCTTTC	0.373			NA											31	99					3.11337e-16	3.85606e-16	0.013726	1	0
CRY1	1407	broad.mit.edu	37	12	107393851	107393851	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:107393851C>T	uc001tmi.3	-	6	1553	c.694G>A	c.(694-696)GCA>ACA	p.A232T		NM_004075	NP_004066	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	232	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			ovary(3)	3						TCAAAATTTGCCACCCAAGCC	0.348			NA											4	82					0	0	0.009096	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686656	108686656	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:108686656C>T	uc009zuw.2	-	3	275	c.84G>A	c.(82-84)TTG>TTA	p.L28L	CMKLR1_uc001tmw.2_Silent_p.L28L|CMKLR1_uc001tmv.2_Silent_p.L26L|CMKLR1_uc009zuv.2_Silent_p.L28L	NM_001142345	NP_001135817	Q99788	CML1_HUMAN	chemokine-like receptor 1 isoform a	28	Extracellular (Potential).				chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			lung(3)|ovary(1)|pancreas(1)	5						ATAAGTCCTCCAAAACCACAA	0.493			NA											30	49					0	0	0.007291	0	0
ACACB	32	broad.mit.edu	37	12	109647064	109647064	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:109647064G>A	uc001tob.2	+	21	3274	c.3155G>A	c.(3154-3156)CGC>CAC	p.R1052H	ACACB_uc001toc.2_Missense_Mutation_p.R1052H	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1052					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	GTGGCAGGCCGCATCCCCGCC	0.637			NA											3	13					0	0	0.004672	0	0
HVCN1	84329	broad.mit.edu	37	12	111099066	111099066	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:111099066G>A	uc001trs.1	-	4	374	c.209C>T	c.(208-210)GCA>GTA	p.A70V	HVCN1_uc001trq.1_Missense_Mutation_p.A70V|HVCN1_uc001trt.1_Missense_Mutation_p.A70V|HVCN1_uc010syd.1_Missense_Mutation_p.A50V	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	70	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						GTCAGGGGCTGCAGCTCTGCC	0.517			NA											10	50					0	0	0.016723	0	0
DHX37	57647	broad.mit.edu	37	12	125435313	125435313	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:125435313C>A	uc001ugy.2	-	22	3005	c.2906G>T	c.(2905-2907)AGC>ATC	p.S969I	DHX37_uc001ugz.1_Missense_Mutation_p.S56I	NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	969							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		AAGGACGGAGCTGGGGTGGAT	0.567			NA											158	120					1.08359e-82	1.55592e-82	0.01441	1	0
ANKLE2	23141	broad.mit.edu	37	12	133331681	133331681	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:133331681G>C	uc001ukx.2	-	2	287	c.220C>G	c.(220-222)CTT>GTT	p.L74V	ANKLE2_uc001uky.3_Missense_Mutation_p.L12V	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	74	LEM.					cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		GGATTCAGAAGTTTCAATCGA	0.403			NA											32	133					0	0	0.009535	0	0
FRY	10129	broad.mit.edu	37	13	32776615	32776615	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:32776615A>T	uc001utx.2	+	31	4465	c.3969A>T	c.(3967-3969)TCA>TCT	p.S1323S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1323					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCTCTTGTCATGTGAGCTGG	0.493			NA											88	66					0	0	0.01441	0	0
DCLK1	9201	broad.mit.edu	37	13	36700141	36700141	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:36700141C>A	uc001uvf.2	-	2	367	c.134G>T	c.(133-135)CGC>CTC	p.R45L		NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	45					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		CTGCAGCGTGCGGGTGCGGTA	0.592			NA											65	54					1.26778e-28	1.69614e-28	0.01441	1	0
SPG20	23111	broad.mit.edu	37	13	36909952	36909952	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:36909952G>C	uc001uvn.2	-	3	286	c.16C>G	c.(16-18)CAA>GAA	p.Q6E	SPG20_uc010ten.1_Missense_Mutation_p.Q6E|SPG20_uc001uvm.2_Missense_Mutation_p.Q6E|SPG20_uc001uvo.2_Missense_Mutation_p.Q6E|SPG20_uc001uvq.2_Missense_Mutation_p.Q6E|SPG20_uc001uvp.2_Missense_Mutation_p.Q6E	NM_001142296	NP_001135768	Q8N0X7	SPG20_HUMAN	spartin	6					cell death	cytoplasm	ubiquitin protein ligase binding				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		TCTCCATTTTGTGGCTCTTGC	0.234			NA											51	58					0	0	0.01441	0	0
TRPC4	7223	broad.mit.edu	37	13	38266459	38266459	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:38266459G>T	uc001uws.2	-	4	1146	c.911C>A	c.(910-912)CCC>CAC	p.P304H	TRPC4_uc010abv.2_Intron|TRPC4_uc001uwt.2_Missense_Mutation_p.P304H|TRPC4_uc010tey.1_Missense_Mutation_p.P304H|TRPC4_uc010abw.2_Missense_Mutation_p.P131H|TRPC4_uc010abx.2_Missense_Mutation_p.P304H|TRPC4_uc010aby.2_Missense_Mutation_p.P304H	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	304	Cytoplasmic (Potential).|Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTGACAATTGGGCTGGGCAAC	0.438			NA											28	22					1.12875e-08	1.27697e-08	0.00632	1	0
AKAP11	11215	broad.mit.edu	37	13	42876762	42876762	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:42876762G>C	uc001uys.1	+	8	4055	c.3880G>C	c.(3880-3882)GGT>CGT	p.G1294R		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1294					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TTATGCTGATGGTGACGAAGA	0.398			NA											7	80					0	0	0.00308	0	0
EDNRB	1910	broad.mit.edu	37	13	78492316	78492316	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:78492316G>C	uc001vko.2	-	1	651	c.393C>G	c.(391-393)TGC>TGG	p.C131W	uc001vks.2_5'Flank|EDNRB_uc001vkq.1_Missense_Mutation_p.C131W|EDNRB_uc010aez.1_Missense_Mutation_p.C131W|EDNRB_uc001vkp.1_Missense_Mutation_p.C214W|EDNRB_uc010afa.1_Missense_Mutation_p.C131W	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	131	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	CGTTTCGCATGCACTTGTTCT	0.483			NA											75	61					0	0	0.01441	0	0
SLC10A2	6555	broad.mit.edu	37	13	103703714	103703714	+	Missense_Mutation	SNP	G	G	T	rs140050923		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr13:103703714G>T	uc001vpy.3	-	4	1251	c.654C>A	c.(652-654)AGC>AGA	p.S218R		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	218	Cytoplasmic (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGATCCAGGCGCTTTGGTACA	0.478			NA											61	63					7.55815e-43	1.04878e-42	0.01441	1	0
OR4K2	390431	broad.mit.edu	37	14	20345048	20345048	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:20345048T>A	uc001vwh.1	+	1	622	c.622T>A	c.(622-624)TTG>ATG	p.L208M		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATAATTGCGTTGTCCTGTTT	0.398			NA											115	514					0	0	0.01441	0	0
TEP1	7011	broad.mit.edu	37	14	20859894	20859894	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:20859894C>G	uc001vxe.2	-	13	2001	c.1961G>C	c.(1960-1962)AGG>ACG	p.R654T	TEP1_uc010ahk.2_Missense_Mutation_p.R4T|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.R546T	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	654	TROVE.				telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		CTGTCGGTACCTGTTCAGCAT	0.542			NA											45	198					0	0	0.013114	0	0
JUB	84962	broad.mit.edu	37	14	23445718	23445718	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:23445718A>T	uc001whz.2	-	4	1562	c.1186T>A	c.(1186-1188)TTT>ATT	p.F396I	JUB_uc001why.2_5'UTR	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	396	LIM zinc-binding 1.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GCCTCCTGAAACCCTGAAAAC	0.468	Esophageal Squamous(134;328 1721 9795 37986 41605)		NA											37	214					0	0	0.019004	0	0
MYH6	4624	broad.mit.edu	37	14	23851669	23851669	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:23851669G>T	uc001wjv.2	-	38	5831	c.5764C>A	c.(5764-5766)CTT>ATT	p.L1922I		NM_002471	NP_002462	P13533	MYH6_HUMAN	myosin heavy chain 6	1922	Potential.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			pancreas(2)|ovary(1)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		TTGGCTCGAAGCTTGTTGACC	0.592			NA											33	134					2.61193e-14	3.165e-14	0.009535	1	0
MYH7	4625	broad.mit.edu	37	14	23884664	23884664	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:23884664G>C	uc001wjx.2	-	36	5315	c.5209C>G	c.(5209-5211)CTC>GTC	p.L1737V		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1737	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TCAGTCTGGAGCTGGGACAGG	0.562			NA											5	168					0	0	0.014758	0	0
BAZ1A	11177	broad.mit.edu	37	14	35243536	35243536	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:35243536G>C	uc001wsk.2	-	19	3562	c.2994C>G	c.(2992-2994)ATC>ATG	p.I998M	BAZ1A_uc001wsl.2_Missense_Mutation_p.I966M	NM_013448	NP_038476	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	998					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			lung(2)|central_nervous_system(2)|ovary(1)|breast(1)|skin(1)	7	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		TACAAACCTTGATGGCTCCTA	0.348			NA											4	72					0	0	0.014758	0	0
PRPF39	55015	broad.mit.edu	37	14	45571881	45571881	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:45571881A>G	uc001wvz.3	+	5	889	c.719A>G	c.(718-720)TAT>TGT	p.Y240C	PRPF39_uc001wvy.3_Missense_Mutation_p.Y119C|PRPF39_uc010and.2_Missense_Mutation_p.Y30C	NM_017922	NP_060392	Q86UA1	PRP39_HUMAN	PRP39 pre-mRNA processing factor 39 homolog	240	HAT 4.				mRNA processing|RNA splicing	nucleus	binding			ovary(1)|breast(1)	2						ACACAGCTGTATAGTCATCAT	0.338			NA											87	200					0	0	0.01441	0	0
FKBP3	2287	broad.mit.edu	37	14	45603642	45603642	+	Silent	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:45603642T>A	uc010tqf.1	-	1	91	c.18A>T	c.(16-18)CCA>CCT	p.P6P	FANCM_uc001wwc.2_5'Flank|FANCM_uc001wwd.3_5'Flank|FANCM_uc010anf.2_5'Flank	NM_002013	NP_002004	Q00688	FKBP3_HUMAN	FK506 binding protein 3, 25kDa	6					protein folding	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|receptor activity				0						ACGCCCGCTGTGGAACGGCCG	0.667			NA											17	26					0	0	0.010818	0	0
OTX2	5015	broad.mit.edu	37	14	57268677	57268677	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:57268677C>T	uc001xcp.2	-	3	817	c.646G>A	c.(646-648)GGG>AGG	p.G216R	OTX2_uc010aou.2_Missense_Mutation_p.G216R|OTX2_uc001xcq.2_Missense_Mutation_p.G224R	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	216					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					AGTGTGGCCCCTGGTCCGGGA	0.527			NA											26	113					0	0	0.005443	0	0
SLC35F4	341880	broad.mit.edu	37	14	58031051	58031051	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:58031051G>T	uc001xdb.1	-	8	1368	c.1368C>A	c.(1366-1368)CGC>CGA	p.R456R	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Silent_p.R297R	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TAGCAGCCAGGCGGACAACAT	0.448			NA											3	20					8.12818e-05	8.62313e-05	0.001984	1	0
PPP2R5E	5529	broad.mit.edu	37	14	63888812	63888812	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:63888812C>G	uc001xgd.1	-	4	945	c.355G>C	c.(355-357)GTA>CTA	p.V119L	PPP2R5E_uc010tsf.1_Missense_Mutation_p.V43L|PPP2R5E_uc010tsg.1_Missense_Mutation_p.V43L|PPP2R5E_uc001xge.2_Missense_Mutation_p.V119L|PPP2R5E_uc010tsh.1_Missense_Mutation_p.V119L|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	119					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		TTGCAAGATACCTAAAAATAA	0.448			NA											7	82					0	0	0.001984	0	0
SPTB	6710	broad.mit.edu	37	14	65246605	65246605	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:65246605C>G	uc001xht.2	-	20	4365	c.4311G>C	c.(4309-4311)GAG>GAC	p.E1437D	SPTB_uc001xhr.2_Missense_Mutation_p.E1437D|SPTB_uc001xhs.2_Missense_Mutation_p.E1437D|SPTB_uc001xhu.2_Missense_Mutation_p.E1437D|SPTB_uc010aqi.2_Missense_Mutation_p.E98D	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1437	Spectrin 11.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GGGCAAACAGCTCCCCCAGCT	0.537			NA											54	280					0	0	0.01441	0	0
MAP3K9	4293	broad.mit.edu	37	14	71197442	71197442	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:71197442C>A	uc001xmm.2	-	12	2970	c.2970G>T	c.(2968-2970)GAG>GAT	p.E990D	MAP3K9_uc010ttk.1_Missense_Mutation_p.E718D|MAP3K9_uc001xmk.2_Missense_Mutation_p.E723D|MAP3K9_uc001xml.2_Missense_Mutation_p.E1004D	NM_033141	NP_149132	P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase	990					activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			stomach(2)|lung(1)|central_nervous_system(1)|skin(1)	5				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		GAGGCAGAAACTCCAGAGTCT	0.627	GBM(114;411 1587 13539 28235 50070)		NA											44	78					1.0331e-37	1.42096e-37	0.01441	1	0
NUMB	8650	broad.mit.edu	37	14	73743882	73743882	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:73743882G>A	uc001xny.1	-	13	1680	c.1360C>T	c.(1360-1362)CAG>TAG	p.Q454*	NUMB_uc010aro.1_Nonsense_Mutation_p.Q259*|NUMB_uc010arp.1_Nonsense_Mutation_p.Q248*|NUMB_uc010arq.1_Nonsense_Mutation_p.Q308*|NUMB_uc010arr.1_Nonsense_Mutation_p.Q297*|NUMB_uc001xoa.1_Nonsense_Mutation_p.Q406*|NUMB_uc001xnz.1_Nonsense_Mutation_p.Q443*|NUMB_uc001xob.1_Nonsense_Mutation_p.Q395*|NUMB_uc001xod.1_Nonsense_Mutation_p.Q406*|NUMB_uc001xoc.1_Nonsense_Mutation_p.Q454*|NUMB_uc010ars.1_Nonsense_Mutation_p.Q443*|NUMB_uc010ttz.1_Nonsense_Mutation_p.Q152*|NUMB_uc001xoe.2_RNA	NM_001005743	NP_001005743	P49757	NUMB_HUMAN	numb homolog isoform 1	454					axon guidance|lateral ventricle development|neuroblast division in subventricular zone|positive regulation of neurogenesis	integral to plasma membrane				ovary(2)|central_nervous_system(1)|skin(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.00471)|OV - Ovarian serous cystadenocarcinoma(108;0.161)		TGGGGCTGCTGAGCCCGGACG	0.602			NA											16	53					0	0	0.003163	0	0
C14orf169	79697	broad.mit.edu	37	14	73959323	73959323	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:73959323A>T	uc001xok.1	+	3	1681	c.1602A>T	c.(1600-1602)GAA>GAT	p.E534D	HEATR4_uc010tua.1_Intron	NM_024644	NP_078920	Q9H6W3	NO66_HUMAN	chromosome 14 open reading frame 169	534					negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm	histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K4 specific)|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0				BRCA - Breast invasive adenocarcinoma(234;0.0033)|OV - Ovarian serous cystadenocarcinoma(108;0.215)		AGGCTGGAGAACCTGTAAACG	0.527			NA											14	62					0	0	0.020292	0	0
LTBP2	4053	broad.mit.edu	37	14	74975375	74975375	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:74975375C>T	uc001xqa.2	-	24	3971	c.3584G>A	c.(3583-3585)AGC>AAC	p.S1195N		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1195	Cys-rich.|EGF-like 12; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGACCCGTGGCTGTTGAGGCA	0.632			NA											19	62					0	0	0.014323	0	0
NRXN3	9369	broad.mit.edu	37	14	79434538	79434538	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:79434538G>T	uc001xun.2	+	11	2363	c.1872G>T	c.(1870-1872)CTG>CTT	p.L624L	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.L749L	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	997	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TGGCTGGTCTGGCCCAAGGCA	0.488			NA											42	62					4.0306e-16	4.96854e-16	0.01441	1	0
NRXN3	9369	broad.mit.edu	37	14	80328143	80328143	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:80328143T>C	uc001xun.2	+	17	3513	c.3022T>C	c.(3022-3024)TAC>CAC	p.Y1008H	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.Y584H|NRXN3_uc010asw.2_Missense_Mutation_p.Y406H|NRXN3_uc001xur.3_Missense_Mutation_p.Y379H	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1590	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GTACGCCATGTACAAGTACAG	0.587			NA											18	57					0	0	0.00499	0	0
PTPN21	11099	broad.mit.edu	37	14	89016693	89016693	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:89016693C>A	uc001xwv.3	-	2	400	c.69G>T	c.(67-69)CTG>CTT	p.L23L	PTPN21_uc010twc.1_5'UTR|PTPN21_uc010atf.1_Silent_p.L23L	NM_007039	NP_008970	Q16825	PTN21_HUMAN	protein tyrosine phosphatase, non-receptor type	23	FERM.					cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			ovary(3)|skin(1)	4						TCCGGGCAACCAGGCAACTCT	0.557			NA											46	138					5.2432e-18	6.61944e-18	0.01441	1	0
CLMN	79789	broad.mit.edu	37	14	95677189	95677189	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:95677189C>G	uc001yef.2	-	7	752	c.636G>C	c.(634-636)GCG>GCC	p.A212A		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	212	Actin-binding.|CH 2.					integral to membrane	actin binding				0				Epithelial(152;0.193)		TCCAACTGCCCGCAAAGTCCT	0.562			NA											19	193					0	0	0.008361	0	0
ATG2B	55102	broad.mit.edu	37	14	96777950	96777950	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:96777950C>A	uc001yfi.2	-	27	4284	c.3919G>T	c.(3919-3921)GTT>TTT	p.V1307F		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1307										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		ATCACACGAACATAATCTAAA	0.313			NA											20	71					1.28384e-07	1.42973e-07	0.012319	1	0
CDC42BPB	9578	broad.mit.edu	37	14	103412024	103412024	+	Silent	SNP	G	G	C	rs141924737		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:103412024G>C	uc001ymi.1	-	29	4018	c.3786C>G	c.(3784-3786)CTC>CTG	p.L1262L	CDC42BPB_uc001ymj.1_Silent_p.L364L	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1262	CNH.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CTATGACATAGAGCCCTTCTT	0.473			NA											12	67					0	0	0.013537	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104251168	104251168	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:104251168G>A	uc001yof.1	-	3	524	c.241C>T	c.(241-243)CGA>TGA	p.R81*	PPP1R13B_uc001yog.1_5'UTR	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	81					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TCCTCGTGTCGAAGGAAAAAT	0.393			NA											23	82					0	0	0.014323	0	0
ADAM6	8755	broad.mit.edu	37	14	107122205	107122205	+	Splice_Site	SNP	C	C	G	rs113057405	by1000genomes	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr14:107122205C>G	uc010tyt.1	-	75		c.3728_splice	c.e75+1							Parts of antibodies, mostly variable regions.												0						TTCACAGACGCGGCGTATTCT	0.488			NA											31	51					0	0	0.007291	0	0
CYFIP1	23191	broad.mit.edu	37	15	23000107	23000107	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:23000107G>C	uc001yus.2	+	30	3565	c.3461G>C	c.(3460-3462)GGT>GCT	p.G1154A	CYFIP1_uc001yut.2_Missense_Mutation_p.G1154A|CYFIP1_uc001yuu.2_Missense_Mutation_p.G723A|CYFIP1_uc001yuv.2_Missense_Mutation_p.G348A	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	1154					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CAGTGCTTTGGTGATGGGCTA	0.483			NA											21	78					0	0	0.01892	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889431	23889431	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:23889431A>T	uc001ywj.3	-	1	1745	c.1650T>A	c.(1648-1650)ACT>ACA	p.T550T		NM_019066	NP_061939			MAGE-like protein 2												0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGAGCTTCTTAGTATTTCCAA	0.473			NA											4	65					0	0	0.009096	0	0
C15orf2	23742	broad.mit.edu	37	15	24921525	24921525	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:24921525G>C	uc001ywo.2	+	1	985	c.511G>C	c.(511-513)GGG>CGG	p.G171R		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	171					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GCAGATCGAAGGGGAGGATGA	0.612			NA											17	87					0	0	0.007413	0	0
GABRB3	2562	broad.mit.edu	37	15	26806314	26806314	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:26806314G>T	uc001zaz.2	-	8	987	c.845C>A	c.(844-846)ACT>AAT	p.T282N	GABRB3_uc010uae.1_Missense_Mutation_p.T197N|GABRB3_uc001zba.2_Missense_Mutation_p.T282N|GABRB3_uc001zbb.2_Missense_Mutation_p.T338N	NM_000814	NP_000805	P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	282	Helical; (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			upper_aerodigestive_tract(1)|ovary(1)|lung(1)|liver(1)|central_nervous_system(1)	5		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TGTCAGCACAGTTGTGATCCC	0.438			NA											32	104					1.99505e-19	2.55994e-19	0.012213	1	0
OCA2	4948	broad.mit.edu	37	15	28116363	28116363	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:28116363C>G	uc001zbh.3	-	21	2291	c.2181G>C	c.(2179-2181)CTG>CTC	p.L727L	OCA2_uc010ayv.2_Silent_p.L703L	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	727	Helical; (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		CCCACACCACCAGGACAATGG	0.562			NA							Oculocutaneous_Albinism				5	91					0	0	0.001984	0	0
OTUD7A	161725	broad.mit.edu	37	15	31862303	31862303	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:31862303A>G	uc001zfq.2	-	2	342	c.249T>C	c.(247-249)GGT>GGC	p.G83G	OTUD7A_uc001zfr.2_Silent_p.G83G|OTUD7A_uc001zfs.1_RNA|OTUD7A_uc010baa.1_Silent_p.G83G	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	83						cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GCTGCTTGGGACCCCGCCCTT	0.622			NA											12	94					0	0	0.00499	0	0
ARHGAP11A	9824	broad.mit.edu	37	15	32928496	32928496	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:32928496A>G	uc001zgy.1	+	12	2244	c.1522A>G	c.(1522-1524)ACT>GCT	p.T508A	ARHGAP11A_uc010ubw.1_Missense_Mutation_p.T319A|ARHGAP11A_uc010ubx.1_Missense_Mutation_p.T319A	NM_014783	NP_055598	Q6P4F7	RHGBA_HUMAN	Rho GTPase activating protein 11A isoform 1	508					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			skin(3)|breast(2)|urinary_tract(1)	6		all_lung(180;1.3e-11)		all cancers(64;3.34e-21)|Epithelial(43;2.64e-15)|GBM - Glioblastoma multiforme(186;5.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.00112)|Lung(196;0.227)		AACCTTACTAACTCCAGAGCG	0.358	Colon(45;757 1134 30003 36652)		NA											16	86					0	0	0.006122	0	0
RYR3	6263	broad.mit.edu	37	15	33955875	33955875	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:33955875G>A	uc001zhi.2	+	36	5626	c.5556G>A	c.(5554-5556)CTG>CTA	p.L1852L	RYR3_uc010bar.2_Silent_p.L1852L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1852	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCAGGCCCTGAACATGTCTG	0.567			NA											5	35					0	0	0.001168	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42434278	42434278	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:42434278G>A	uc001zoz.2	-	20	2517	c.2454C>T	c.(2452-2454)CTC>CTT	p.L818L	PLA2G4F_uc010bcq.2_Silent_p.L115L|PLA2G4F_uc001zoy.2_Silent_p.L450L|PLA2G4F_uc010bcr.2_Silent_p.L569L|PLA2G4F_uc001zpa.2_Silent_p.L569L|PLA2G4F_uc010bcs.2_Silent_p.L605L	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	818	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		TGTATCGACTGAGGGCCACCA	0.587			NA											11	70					0	0	0.008291	0	0
UBR1	197131	broad.mit.edu	37	15	43258422	43258422	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:43258422G>A	uc001zqq.2	-	41	4586	c.4520C>T	c.(4519-4521)CCT>CTT	p.P1507L		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1507					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GCGAAGATAAGGGGTGATGCC	0.433			NA											6	94					0	0	0.001168	0	0
UNC13C	440279	broad.mit.edu	37	15	54305855	54305855	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:54305855G>T	uc002ack.2	+	1	755	c.755G>T	c.(754-756)GGA>GTA	p.G252V		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	252					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GAACTTCAGGGAATAAGTCAG	0.463			NA											30	95					2.4375e-19	3.11238e-19	0.007291	1	0
UNC13C	440279	broad.mit.edu	37	15	54306827	54306827	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:54306827G>T	uc002ack.2	+	1	1727	c.1727G>T	c.(1726-1728)AGC>ATC	p.S576I		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	576					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ACTAATGGAAGCTCTCTCCTG	0.433			NA											12	51					9.05144e-12	1.06872e-11	0.016723	1	0
UNC13C	440279	broad.mit.edu	37	15	54307661	54307661	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:54307661C>A	uc002ack.2	+	1	2561	c.2561C>A	c.(2560-2562)ACG>AAG	p.T854K		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	854					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		GATGTCTACACGGAGCCCTAT	0.423			NA											28	55					2.4375e-19	3.11238e-19	0.007291	1	0
TCF12	6938	broad.mit.edu	37	15	57525012	57525012	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:57525012G>A	uc002aec.2	+	11	1212	c.928G>A	c.(928-930)GCC>ACC	p.A310T	TCF12_uc010ugm.1_Missense_Mutation_p.A362T|TCF12_uc010ugn.1_Missense_Mutation_p.A306T|TCF12_uc002aea.2_Missense_Mutation_p.A310T|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Missense_Mutation_p.A310T|TCF12_uc002aed.2_Missense_Mutation_p.A310T|TCF12_uc002aee.2_Missense_Mutation_p.A140T|TCF12_uc010bft.2_Missense_Mutation_p.A140T|TCF12_uc010ugo.1_Missense_Mutation_p.A74T	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	310					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		TTACGTTGCTGCCTCACACAC	0.473			NA	T	TEC	extraskeletal myxoid chondrosarcoma								35	62					0	0	0.021022	0	0
AQP9	366	broad.mit.edu	37	15	58458996	58458996	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:58458996C>T	uc002aez.2	+	2	593	c.236C>T	c.(235-237)TCT>TTT	p.S79F	ALDH1A2_uc010ugw.1_Intron|AQP9_uc010ugx.1_Missense_Mutation_p.S14F	NM_020980	NP_066190	O43315	AQP9_HUMAN	aquaporin 9	79	Cytoplasmic (Potential).				cellular response to cAMP|excretion|immune response|metabolic process|response to mercury ion|response to osmotic stress|water homeostasis	integral to plasma membrane|intracellular membrane-bounded organelle	amine transmembrane transporter activity|carboxylic acid transmembrane transporter activity|glycerol channel activity|porin activity|purine base transmembrane transporter activity|pyrimidine base transmembrane transporter activity|water channel activity			ovary(1)	1				GBM - Glioblastoma multiforme(80;0.16)		GGCGGTGTCTCTGGTAAGCAG	0.269			NA											18	193					0	0	0.00499	0	0
LIPC	3990	broad.mit.edu	37	15	58830684	58830684	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:58830684C>A	uc010bga.1	+	4	849	c.241C>A	c.(241-243)CTG>ATG	p.L81M	LIPC_uc010bfz.1_Missense_Mutation_p.L81M|LIPC_uc002afa.1_Missense_Mutation_p.L81M|LIPC_uc010bgb.1_Intron|LIPC_uc010ugy.1_Missense_Mutation_p.L81M	NM_000236	NP_000227	P11150	LIPC_HUMAN	lipase C precursor	81					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			ovary(1)	1		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		CAACTCCTCCCTGCCTCTGGT	0.473			NA											65	200					1.40369e-38	1.93748e-38	0.01441	1	0
FAM96A	84191	broad.mit.edu	37	15	64380925	64380925	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:64380925T>A	uc002amt.1	-	2	490	c.250A>T	c.(250-252)ACG>TCG	p.T84S	FAM96A_uc002amu.1_Missense_Mutation_p.T84S|FAM96A_uc010uin.1_Missense_Mutation_p.T84S	NM_032231	NP_115607	Q9H5X1	FA96A_HUMAN	family with sequence similarity 96, member A	84					chromosome segregation						0						ACTGTTGGCGTGAACCTGATA	0.348			NA											15	46					0	0	0.003163	0	0
PLEKHO2	80301	broad.mit.edu	37	15	65157686	65157686	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:65157686G>T	uc002anv.2	+	6	1206	c.1072G>T	c.(1072-1074)GCT>TCT	p.A358S	PLEKHO2_uc010bgz.2_Missense_Mutation_p.A34S|PLEKHO2_uc002anw.2_Missense_Mutation_p.A308S	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	358	Pro-rich.									ovary(1)|lung(1)	2						GCCCTCTCAGGCTGAGGGCAC	0.617			NA											31	76					9.78306e-22	1.26985e-21	0.009535	1	0
NEO1	4756	broad.mit.edu	37	15	73528761	73528761	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:73528761C>G	uc002avm.3	+	8	1507	c.1365C>G	c.(1363-1365)ATC>ATG	p.I455M	NEO1_uc010ukx.1_Missense_Mutation_p.I455M|NEO1_uc010uky.1_Missense_Mutation_p.I455M|NEO1_uc010ukz.1_Translation_Start_Site|NEO1_uc002avn.3_Missense_Mutation_p.I120M	NM_002499	NP_002490	Q92859	NEO1_HUMAN	neogenin homolog 1 precursor	455	Extracellular (Potential).|Fibronectin type-III 1.				axon guidance|cell adhesion|positive regulation of muscle cell differentiation	Golgi apparatus|integral to plasma membrane|nucleus				pancreas(1)	1						CCCGCTTCATCAAATTGACGT	0.552			NA											55	186					0	0	0.01441	0	0
CYP1A1	1543	broad.mit.edu	37	15	75014042	75014042	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:75014042A>T	uc002ayp.3	-	3	964	c.842T>A	c.(841-843)ATC>AAC	p.I281N	CYP1A1_uc010bjv.2_RNA|CYP1A1_uc010bjw.2_RNA|CYP1A1_uc010bju.2_Missense_Mutation_p.I17N|CYP1A1_uc010bjx.2_Missense_Mutation_p.I17N|CYP1A1_uc002ayq.3_Missense_Mutation_p.I281N|CYP1A1_uc010bjy.2_Missense_Mutation_p.I281N|CYP1A1_uc010bjz.1_Missense_Mutation_p.I17N	NM_000499	NP_000490	P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A,	281					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			ovary(2)|breast(2)|pancreas(1)	5					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	GCTGTCTGTGATGTCCCGGAT	0.512			NA							Endometrial_Cancer_Familial_Clustering_of|ACTH-independent_macronodular_adrenal_hyperplasia				25	118					0	0	0.004656	0	0
C15orf26	161502	broad.mit.edu	37	15	81428997	81428997	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:81428997G>A	uc002bgb.2	+	3	327	c.300G>A	c.(298-300)CAG>CAA	p.Q100Q	C15orf26_uc010blp.1_Silent_p.Q75Q	NM_173528	NP_775799	Q6P656	CO026_HUMAN	hypothetical protein LOC161502	100											0						ATGAAATTCAGTCCCATCTGA	0.468			NA											26	110					0	0	0.005443	0	0
IL16	3603	broad.mit.edu	37	15	81591951	81591951	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:81591951G>A	uc002bgh.3	+	14	2660	c.2284G>A	c.(2284-2286)GAC>AAC	p.D762N	IL16_uc010blq.1_Missense_Mutation_p.D716N|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.D804N|IL16_uc002bgg.2_Missense_Mutation_p.D762N|IL16_uc002bgi.1_Missense_Mutation_p.D152N|IL16_uc002bgj.2_Missense_Mutation_p.D256N|IL16_uc002bgk.2_Missense_Mutation_p.D61N|IL16_uc002bgl.1_Missense_Mutation_p.D61N|IL16_uc010unq.1_Missense_Mutation_p.D61N	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	762					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						ACCAAAGCTGGACACCGCCAA	0.562			NA											18	98					0	0	0.007413	0	0
EFTUD1	79631	broad.mit.edu	37	15	82533698	82533698	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:82533698C>A	uc002bgt.1	-	5	460	c.291G>T	c.(289-291)GTG>GTT	p.V97V	EFTUD1_uc002bgu.1_Silent_p.V46V	NM_024580	NP_078856	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain	97					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			ovary(1)	1						AGGAAAAGTCCACGTGTCCTG	0.423			NA											14	55					4.3838e-07	4.8407e-07	0.016723	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611402	84611402	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:84611402G>T	uc002bjz.3	+	18	2396	c.2172G>T	c.(2170-2172)CAG>CAT	p.Q724H	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.Q724H|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.Q724H	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	724	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TTGGAATTCAGACCCGAGATG	0.532			NA											33	120					1.26612e-14	1.54376e-14	0.015359	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84683293	84683294	+	Splice_Site	DNP	GG	GG	TT			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:84683293_84683294GG>TT	uc002bjz.3	+	24	4198	c.3974_splice	c.e24-1	p.G1325_splice	ADAMTSL3_uc010bmt.1_Splice_Site_p.G1325_splice|ADAMTSL3_uc010bmu.1_Splice_Site_p.G1325_splice	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor							proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TTGTTCCAAAGGTGTCCCTCAG	0.416			NA											32	138					0	0	0.004672	0	0
NTRK3	4916	broad.mit.edu	37	15	88678465	88678465	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:88678465C>A	uc002bme.1	-	9	1233	c.1071G>T	c.(1069-1071)GAG>GAT	p.E357D	NTRK3_uc002bmh.2_Missense_Mutation_p.E357D|NTRK3_uc002bmf.1_Missense_Mutation_p.E357D|NTRK3_uc010upl.1_Missense_Mutation_p.E259D|NTRK3_uc010bnh.1_Missense_Mutation_p.E357D|NTRK3_uc002bmg.2_Missense_Mutation_p.E357D	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	357	Ig-like C2-type 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCTCGGAAATCTCTCCCTCTT	0.562			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			26	135					7.76418e-22	1.00947e-21	0.005443	1	0
HAPLN3	145864	broad.mit.edu	37	15	89424754	89424754	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:89424754G>C	uc002bnc.2	-	3	455	c.327C>G	c.(325-327)CAC>CAG	p.H109Q	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.H171Q	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	109	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					CAAAGGAGCGGTGCCTCAGCC	0.657			NA											25	96					0	0	0.01892	0	0
PEX11A	8800	broad.mit.edu	37	15	90226986	90226986	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr15:90226986C>G	uc002boi.2	-	3	461	c.366G>C	c.(364-366)AGG>AGC	p.R122S	PEX11A_uc010upy.1_RNA	NM_003847	NP_003838	O75192	PX11A_HUMAN	peroxisomal biogenesis factor 11 alpha	122	Lumenal (Potential).				cellular lipid metabolic process|peroxisome fission|signal transduction	integral to peroxisomal membrane					0	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			GGTGAGCAGCCCTCGTTCGCC	0.493			NA											21	178					0	0	0.008871	0	0
Unknown	0	broad.mit.edu	37	16	66989	66989	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:66989A>C	uc002cfg.1	-	5	1306	c.647T>G	c.(646-648)CTG>CGG	p.L216R		NM_182905	NP_878908			WAS protein family homolog 1												NA						CTCTGCCCCCAGCATCACATG	0.582			NA											9	29					0	0	0.006214	0	0
MSLNL	401827	broad.mit.edu	37	16	819450	819450	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:819450A>C	uc002cjz.1	-	16	3140	c.3140T>G	c.(3139-3141)CTT>CGT	p.L1047R	MIR662_hsa-mir-662|MI0003670_5'Flank	NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	696	Cytoplasmic (Potential).				cell adhesion	integral to membrane				breast(3)|ovary(1)	4						CGTCAGCCCAAGTGGGCGTCC	0.627			NA											17	91					0	0	0.00499	0	0
SSTR5	6755	broad.mit.edu	37	16	1129358	1129358	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:1129358T>A	uc002ckq.2	+	1	578	c.490T>A	c.(490-492)TGG>AGG	p.W164R	LOC146336_uc002cko.2_5'Flank|LOC146336_uc002ckp.1_5'Flank	NM_001053	NP_001044	P35346	SSR5_HUMAN	somatostatin receptor 5	164	Helical; Name=4; (Potential).				negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			lung(1)	1		Hepatocellular(780;0.00369)			Octreotide(DB00104)	CGCCGCGGCCTGGGTCCTGTC	0.721			NA											3	9					0	0	0.006214	0	0
MKL2	57496	broad.mit.edu	37	16	14340513	14340513	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:14340513C>T	uc010uza.1	+	12	1551	c.1396C>T	c.(1396-1398)CCG>TCG	p.P466S	MKL2_uc002dcg.2_Missense_Mutation_p.P466S|MKL2_uc002dcj.2_5'Flank	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein	455					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						TGTGGCCTTGCCGGTTACAAC	0.532			NA											4	193					0	0	0.009096	0	0
MYH11	4629	broad.mit.edu	37	16	15917231	15917231	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:15917231T>C	uc002ddy.2	-	3	490	c.383A>G	c.(382-384)TAT>TGT	p.Y128C	MYH11_uc002ddv.2_Missense_Mutation_p.Y128C|MYH11_uc002ddw.2_Missense_Mutation_p.Y128C|MYH11_uc002ddx.2_Missense_Mutation_p.Y128C|MYH11_uc010bvg.2_5'UTR|MYH11_uc002deb.3_Missense_Mutation_p.Y128C	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	128	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CAGGTGTTTATAGGGGTTGAC	0.557			NA	T	CBFB	AML								75	158					0	0	0.01441	0	0
PDILT	204474	broad.mit.edu	37	16	20410590	20410590	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:20410590C>T	uc002dhc.1	-	2	256	c.33G>A	c.(31-33)GTG>GTA	p.V11V		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	11					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						CACAAGCGGCCACCAGCAGCA	0.587			NA											37	175					0	0	0.009718	0	0
ACSM1	116285	broad.mit.edu	37	16	20636757	20636757	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:20636757C>A	uc002dhm.1	-	11	1583	c.1515G>T	c.(1513-1515)CCG>CCT	p.P505P	ACSM1_uc002dhn.1_Intron|ACSM1_uc010bwg.1_Silent_p.P505P	NM_052956	NP_443188	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member	505					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|skin(1)	2						CCCCTCGAATCGGGTCTGGGC	0.602			NA											25	52					1.12875e-08	1.27697e-08	0.00632	1	0
OTOA	146183	broad.mit.edu	37	16	21739597	21739597	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:21739597C>T	uc002djh.2	+	19	2053	c.2052C>T	c.(2050-2052)ATC>ATT	p.I684I	uc002diq.3_Intron|OTOA_uc010vbj.1_Silent_p.I605I|OTOA_uc002dji.2_Silent_p.I360I|OTOA_uc010vbk.1_Silent_p.I332I	NM_144672	NP_653273	Q7RTW8	OTOAN_HUMAN	otoancorin isoform 1	698					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(48;0.0414)		CTGTGGACATCATGGGGAACC	0.557			NA											57	135					0	0	0.01441	0	0
IL21R	50615	broad.mit.edu	37	16	27456538	27456538	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:27456538C>G	uc002doq.1	+	7	959	c.726C>G	c.(724-726)CTC>CTG	p.L242L	IL21R_uc002dor.1_Silent_p.L242L|IL21R_uc002dos.1_Silent_p.L242L	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	242	Helical; (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						TGCTTCTCCTCCTGCTTGTCA	0.542			NA	T	BCL6	NHL								28	69					0	0	0.007291	0	0
SPN	6693	broad.mit.edu	37	16	29675057	29675057	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:29675057C>T	uc002dtm.2	+	2	144	c.8C>T	c.(7-9)ACG>ATG	p.T3M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SPN_uc002dtn.2_Missense_Mutation_p.T3M|SPN_uc010bzd.2_RNA	NM_001030288	NP_001025459	P16150	LEUK_HUMAN	sialophorin precursor	3					blood coagulation|cellular defense response|chemotaxis|defense response to bacterium|establishment or maintenance of cell polarity|immune response|leukocyte migration|negative regulation of cell adhesion|positive regulation of tumor necrosis factor biosynthetic process	extracellular space|integral to plasma membrane	bacterial cell surface binding|transmembrane receptor activity			central_nervous_system(2)	2						GAAATGGCCACGCTTCTCCTT	0.632			NA											8	448					0	0	0.004482	0	0
SRCAP	10847	broad.mit.edu	37	16	30721220	30721220	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:30721220C>T	uc002dze.1	+	8	1290	c.905C>T	c.(904-906)ACG>ATG	p.T302M	SRCAP_uc002dzf.2_RNA|SRCAP_uc002dzg.1_Missense_Mutation_p.T159M|SRCAP_uc010bzz.1_Translation_Start_Site|SNORA30_uc002dzh.1_5'Flank	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	302	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GATGAGGAAACGATTGAAGTT	0.532			NA											11	105					0	0	0.010729	0	0
CNOT1	23019	broad.mit.edu	37	16	58580244	58580244	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:58580244G>C	uc002env.2	-	29	4280	c.3987C>G	c.(3985-3987)CTC>CTG	p.L1329L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L1324L|CNOT1_uc002enx.2_Silent_p.L1329L|CNOT1_uc010vik.1_Silent_p.L286L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1329					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TGATGGGAGGGAGTTCTTCTG	0.413			NA											22	118					0	0	0.01892	0	0
CDH11	1009	broad.mit.edu	37	16	64981591	64981591	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:64981591T>C	uc002eoi.2	-	13	2740	c.2306A>G	c.(2305-2307)TAT>TGT	p.Y769C	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Missense_Mutation_p.Y643C	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	769	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TAGATAATCATAGTCCAAGTC	0.448			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			68	135					0	0	0.01441	0	0
DPEP2	64174	broad.mit.edu	37	16	68026508	68026508	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:68026508C>A	uc010cey.2	-	2	459	c.295G>T	c.(295-297)GTT>TTT	p.V99F	DPEP2_uc002evd.3_Missense_Mutation_p.V99F|DPEP2_uc002eve.2_Missense_Mutation_p.V99F|DPEP2_uc002evf.2_RNA|DPEP2_uc002evg.2_Intron	NM_022355	NP_071750	Q9H4A9	DPEP2_HUMAN	dipeptidase 2 precursor	99					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		TTCTGGTAAACCTGCCTTAGG	0.582			NA											41	130					1.48734e-19	1.91473e-19	0.013114	1	0
NFATC3	4775	broad.mit.edu	37	16	68225604	68225604	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:68225604G>A	uc002evo.1	+	9	3242	c.3032G>A	c.(3031-3033)AGC>AAC	p.S1011N	NFATC3_uc010vkl.1_Missense_Mutation_p.S532N|NFATC3_uc010vkm.1_Missense_Mutation_p.S532N|NFATC3_uc010vkn.1_Missense_Mutation_p.S532N|NFATC3_uc010vko.1_Missense_Mutation_p.S532N|NFATC3_uc010vkp.1_Missense_Mutation_p.S532N|NFATC3_uc010vkq.1_Missense_Mutation_p.S532N|NFATC3_uc002evl.2_Missense_Mutation_p.S532N|NFATC3_uc002evk.2_Missense_Mutation_p.S1011N|NFATC3_uc002evm.1_Missense_Mutation_p.S1011N|NFATC3_uc002evn.1_Missense_Mutation_p.S1011N|NFATC3_uc010vkr.1_Missense_Mutation_p.S532N|NFATC3_uc010vks.1_Missense_Mutation_p.S532N|NFATC3_uc010vkt.1_Missense_Mutation_p.S532N|NFATC3_uc010vku.1_Missense_Mutation_p.S532N|NFATC3_uc010vkv.1_Missense_Mutation_p.S532N|NFATC3_uc010vkw.1_Missense_Mutation_p.S532N|NFATC3_uc010vkx.1_Missense_Mutation_p.S532N|NFATC3_uc010vky.1_Missense_Mutation_p.S532N|NFATC3_uc010vkz.1_Missense_Mutation_p.S532N|NFATC3_uc010vla.1_Missense_Mutation_p.S532N|NFATC3_uc010vlb.1_Missense_Mutation_p.S532N|NFATC3_uc010vlc.1_Missense_Mutation_p.S532N	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	1011					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GCAACTGTGAGCATTAAACCT	0.463			NA											137	203					0	0	0.01441	0	0
KIAA0174	9798	broad.mit.edu	37	16	71955338	71955338	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:71955338A>T	uc002fbj.1	+	8	856	c.573A>T	c.(571-573)GAA>GAT	p.E191D	KIAA0174_uc010cgh.1_Missense_Mutation_p.E191D|KIAA0174_uc002fbk.1_Missense_Mutation_p.E178D|KIAA0174_uc002fbm.1_Missense_Mutation_p.E178D|KIAA0174_uc002fbl.1_Missense_Mutation_p.E178D|KIAA0174_uc002fbn.1_Missense_Mutation_p.E30D|KIAA0174_uc010cgi.1_Intron|KIAA0174_uc010cgj.1_Missense_Mutation_p.E110D|KIAA0174_uc010vml.1_5'Flank|KIAA0174_uc010vmk.1_Missense_Mutation_p.E30D			P53990	IST1_HUMAN	SubName: Full=cDNA FLJ32696 fis, clone TESTI2000358; SubName: Full=cDNA FLJ77725;	178	Interaction with VPS37B.				cell cycle|cell division	cytoplasmic membrane-bounded vesicle|ER-Golgi intermediate compartment	protein binding			ovary(1)	1						TACCCTATGAACCTGACTCTG	0.393			NA											12	83					0	0	0.013537	0	0
ZC3H18	124245	broad.mit.edu	37	16	88653008	88653008	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:88653008G>T	uc002fky.2	+	3	804	c.604G>T	c.(604-606)GAT>TAT	p.D202Y	ZC3H18_uc010voy.1_Missense_Mutation_p.D85Y|ZC3H18_uc010voz.1_Missense_Mutation_p.D202Y|ZC3H18_uc010vpa.1_Missense_Mutation_p.D202Y	NM_144604	NP_653205	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	202	Poly-Asp.					nucleus	nucleic acid binding|zinc ion binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0542)		TCTGTTTCAGGATGATGACCT	0.537	Ovarian(121;375 2276 20373 38669)		NA											23	76					2.32416e-17	2.91077e-17	0.014323	1	0
ATP2A3	489	broad.mit.edu	37	17	3844532	3844532	+	Missense_Mutation	SNP	G	G	C	rs140617781		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:3844532G>C	uc002fxb.1	-	14	1984	c.1833C>G	c.(1831-1833)ATC>ATG	p.I611M	ATP2A3_uc002fwx.1_Missense_Mutation_p.I611M|ATP2A3_uc002fwy.1_Missense_Mutation_p.I611M|ATP2A3_uc002fwz.1_Missense_Mutation_p.I611M|ATP2A3_uc002fxa.1_Missense_Mutation_p.I611M|ATP2A3_uc002fxc.1_Missense_Mutation_p.I611M|ATP2A3_uc002fxd.1_Missense_Mutation_p.I611M	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	611	Cytoplasmic (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		AGCAGCGTGTGATGCAGGCAG	0.647	GBM(32;29 774 15719 37967)		NA											3	107					0	0	0.009096	0	0
TP53	7157	broad.mit.edu	37	17	7577551	7577551	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:7577551C>A	uc002gim.2	-	7	924	c.730G>T	c.(730-732)GGC>TGC	p.G244C	TP53_uc002gig.1_Missense_Mutation_p.G244C|TP53_uc002gih.2_Missense_Mutation_p.G244C|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G112C|TP53_uc010cng.1_Missense_Mutation_p.G112C|TP53_uc002gii.1_Missense_Mutation_p.G112C|TP53_uc010cnh.1_Missense_Mutation_p.G244C|TP53_uc010cni.1_Missense_Mutation_p.G244C|TP53_uc002gij.2_Missense_Mutation_p.G244C|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G151C|TP53_uc002gio.2_Missense_Mutation_p.G112C	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	244	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> A (in sporadic cancers; somatic mutation).|G -> S (in sporadic cancers; somatic mutation).|G -> R (in sporadic cancers; somatic mutation).|MG -> IC (in a sporadic cancer; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> C (in sporadic cancers; somatic mutation).|MG -> IS (in a sporadic cancer; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G244C(36)|p.G244S(35)|p.G244D(32)|p.G244V(14)|p.G244G(13)|p.G244A(9)|p.0?(7)|p.G244fs*3(5)|p.G244R(3)|p.M243_G244>IC(1)|p.G244E(1)|p.G244fs*19(1)|p.G151C(1)|p.G244fs*17(1)|p.M243fs*18(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.C242_M246>L(1)|p.G244del(1)|p.C238_M246delCNSSCMGGM(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCATGCCGCCCATGCAGGAA	0.582	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			27	21					4.15321e-07	4.59904e-07	0.009535	1	0
PIK3R5	23533	broad.mit.edu	37	17	8784284	8784284	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:8784284G>A	uc002glt.2	-	18	2500	c.2433C>T	c.(2431-2433)AAC>AAT	p.N811N	PIK3R5_uc010vuz.1_Silent_p.N811N|PIK3R5_uc002glu.3_Silent_p.N425N	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	811					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						AGGGGCAGCTGTTGGAGCCGA	0.562	NSCLC(18;589 615 7696 20311 50332)		NA											38	83					0	0	0.011902	0	0
WDR16	146845	broad.mit.edu	37	17	9532031	9532031	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:9532031C>G	uc002gly.2	+	9	1137	c.1068C>G	c.(1066-1068)ATC>ATG	p.I356M	WDR16_uc002glz.2_Missense_Mutation_p.I288M|WDR16_uc010coc.2_Missense_Mutation_p.I366M	NM_145054	NP_659491	Q8N1V2	WDR16_HUMAN	WD40-repeat protein upregulated in HCC isoform	356	WD 5.					cytoplasm|intracellular membrane-bounded organelle	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						AGAAGGATATCAGGGTGTGGC	0.517			NA											5	87					0	0	0.014758	0	0
MYH4	4622	broad.mit.edu	37	17	10369629	10369629	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:10369629C>T	uc002gmn.2	-	4	420	c.309G>A	c.(307-309)CTG>CTA	p.L103L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	103	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGAGGTTATACAGCACAGCAG	0.458			NA											50	73					0	0	0.01441	0	0
MYH3	4621	broad.mit.edu	37	17	10535936	10535936	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:10535936C>A	uc002gmq.1	-	33	4890	c.4813G>T	c.(4813-4815)GAG>TAG	p.E1605*		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	1605	Potential.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CTCCGCACCTCGGCGTCCAGG	0.557			NA											10	517					1.61879e-10	1.87742e-10	0.013537	1	0
KCNJ12	3768	broad.mit.edu	37	17	21318672	21318672	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:21318672G>T	uc002gyv.1	+	3	723	c.18G>T	c.(16-18)CGG>CGT	p.R6R		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	6	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	CGGCCAGCCGGGCCAACCCCT	0.697			NA								Prostate(3;0.18)			4	40					1.23904e-05	1.32887e-05	0.014758	1	0
NF1	4763	broad.mit.edu	37	17	29657349	29657349	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:29657349G>A	uc002hgg.2	+	39	5978	c.5645G>A	c.(5644-5646)TGT>TAT	p.C1882Y	NF1_uc002hgh.2_Missense_Mutation_p.C1861Y|NF1_uc002hgi.1_Missense_Mutation_p.C894Y|NF1_uc010cso.2_Missense_Mutation_p.C70Y	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1882					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.C1882F(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GCCTTAACTTGTACCTTTAAT	0.353			NA	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			49	78					0	0	0.01441	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349570	30349570	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:30349570A>G	uc002hgu.2	+	1	1416	c.1405A>G	c.(1405-1407)AAG>GAG	p.K469E	LRRC37B_uc010wbx.1_Missense_Mutation_p.K387E|LRRC37B_uc010csu.2_Missense_Mutation_p.K469E	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	469	Extracellular (Potential).			K -> E (in Ref. 2; AAR28082).		integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AGCCCTGGAGAAGACTAGAGC	0.527			NA											55	114					0	0	0.01441	0	0
MED1	5469	broad.mit.edu	37	17	37565297	37565297	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:37565297G>C	uc002hrv.3	-	17	3389	c.3177C>G	c.(3175-3177)CCC>CCG	p.P1059P	MED1_uc010wee.1_Silent_p.P887P|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1059	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTTTGGGAATGGGTGGTGTGG	0.507	Pancreas(21;279 768 2492 4877 24026)		NA								HNSCC(31;0.082)			306	187					0	0	0.01441	0	0
ZPBP2	124626	broad.mit.edu	37	17	38031516	38031516	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:38031516C>T	uc002hte.2	+	7	871	c.718C>T	c.(718-720)CGA>TGA	p.R240*	ZPBP2_uc002htf.2_Nonsense_Mutation_p.R218*	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	240					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			GGCAAGAGATCGAATAGAAGA	0.358			NA											16	162					0	0	0.00499	0	0
ZPBP2	124626	broad.mit.edu	37	17	38031554	38031554	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:38031554C>T	uc002hte.2	+	7	909	c.756C>T	c.(754-756)TTC>TTT	p.F252F	ZPBP2_uc002htf.2_Silent_p.F230F	NM_199321	NP_955353	Q6X784	ZPBP2_HUMAN	zona pellucida binding protein 2 isoform 2	252					binding of sperm to zona pellucida	extracellular region				ovary(1)	1	Colorectal(19;0.000442)		Lung(15;0.00849)|LUSC - Lung squamous cell carcinoma(15;0.171)			CATATATTTTCTACCATAACT	0.373			NA											20	160					0	0	0.008871	0	0
TOP2A	7153	broad.mit.edu	37	17	38545891	38545891	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:38545891C>T	uc002huq.2	-	35	4602	c.4476G>A	c.(4474-4476)AAG>AAA	p.K1492K		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1492					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CACTCTCCCCCTTGGATTTCT	0.398			NA											3	38					0	0	0.009096	0	0
TOP2A	7153	broad.mit.edu	37	17	38546301	38546301	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:38546301C>T	uc002huq.2	-	34	4509	c.4383G>A	c.(4381-4383)AAG>AAA	p.K1461K		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	1461					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TGCGGCGATTCTTGGTTTTGG	0.448			NA											5	63					0	0	0.014758	0	0
TUBG2	27175	broad.mit.edu	37	17	40818442	40818442	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:40818442C>T	uc010wgr.1	+	10	1354	c.1098C>T	c.(1096-1098)TAC>TAT	p.Y366Y	TUBG2_uc002iaq.2_Silent_p.Y208Y|TUBG2_uc002iar.2_Silent_p.Y213Y|TUBG2_uc002ias.2_Silent_p.Y208Y|TUBG2_uc002iap.2_Silent_p.Y213Y	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	366					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		AGTCTCCCTACCTGCCCTCGG	0.602			NA											28	230					0	0	0.007291	0	0
AOC2	314	broad.mit.edu	37	17	40996773	40996773	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:40996773G>A	uc002ibu.2	+	1	165	c.130G>A	c.(130-132)GCC>ACC	p.A44T	AOC2_uc002ibt.2_Missense_Mutation_p.A44T	NM_009590	NP_033720	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 isoform b	44					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			ovary(2)	2		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		ATCCCATAGGGCCCAGCCCTG	0.627			NA											63	485					0	0	0.01441	0	0
PPY	5539	broad.mit.edu	37	17	42018943	42018943	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:42018943G>A	uc002iep.2	-	2	125	c.80C>T	c.(79-81)GCC>GTC	p.A27V		NM_002722	NP_002713	P01298	PAHO_HUMAN	pancreatic polypeptide preproprotein	27					digestion|protein secretion	extracellular region	hormone activity				0		Breast(137;0.00314)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)		GGCTCCCTGGGCACCCAGCAG	0.612			NA											13	69					0	0	0.020292	0	0
UBTF	7343	broad.mit.edu	37	17	42286812	42286812	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:42286812G>A	uc002igb.2	-	16	1880	c.1813C>T	c.(1813-1815)CAG>TAG	p.Q605*	UBTF_uc002igc.2_Nonsense_Mutation_p.Q568*|UBTF_uc010czs.2_Nonsense_Mutation_p.Q605*|UBTF_uc002igd.2_Nonsense_Mutation_p.Q568*|UBTF_uc010czt.2_Nonsense_Mutation_p.Q605*|UBTF_uc002ige.2_Nonsense_Mutation_p.Q568*	NM_014233	NP_055048	P17480	UBF1_HUMAN	upstream binding transcription factor, RNA	605	HMG box 6.				positive regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm	DNA binding|protein binding				0		Breast(137;0.00765)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.114)		GAGATGCGCTGCCAGCGACTG	0.587			NA											22	63					0	0	0.016522	0	0
ACBD4	79777	broad.mit.edu	37	17	43215142	43215142	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:43215142G>A	uc002iid.2	+	7	862	c.518G>A	c.(517-519)AGG>AAG	p.R173K	ACBD4_uc010wjj.1_Missense_Mutation_p.G186R|ACBD4_uc002iie.2_Missense_Mutation_p.G186R|ACBD4_uc002iif.2_Missense_Mutation_p.R173K|ACBD4_uc002iic.2_Missense_Mutation_p.R173K|ACBD4_uc010dae.2_Missense_Mutation_p.G108R	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	173							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						CATTCACCCAGGGACCTGGAC	0.597			NA											115	336					0	0	0.01441	0	0
KIAA1267	284058	broad.mit.edu	37	17	44249381	44249381	+	Silent	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:44249381A>C	uc002ikb.2	-	1	214	c.129T>G	c.(127-129)CTT>CTG	p.L43L	KIAA1267_uc002ikc.2_Silent_p.L43L|KIAA1267_uc002ikd.2_Silent_p.L43L|KIAA1267_uc010dav.2_Silent_p.L43L	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	43						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				TGGCAGCAATAAGGATGTTGG	0.512			NA											4	468					0	0	0.014758	0	0
NSF	4905	broad.mit.edu	37	17	44782158	44782158	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:44782158G>A	uc002iku.2	+	13	1512	c.1408G>A	c.(1408-1410)GCA>ACA	p.A470T	NSF_uc010wke.1_Missense_Mutation_p.A376T|NSF_uc010wkf.1_Missense_Mutation_p.A376T|NSF_uc010wkg.1_Missense_Mutation_p.A465T	NM_006178	NP_006169	P46459	NSF_HUMAN	vesicle-fusing ATPase	470					protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			ovary(1)	1		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		CATGGAGAAAGCAGAAAGCCT	0.378	Ovarian(25;472 742 1472 36813 50223)		NA											17	138					0	0	0.010504	0	0
HOXB1	3211	broad.mit.edu	37	17	46607116	46607116	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:46607116C>A	uc002ink.1	-	2	705	c.699G>T	c.(697-699)AGG>AGT	p.R233S		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	233	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CAATCTCCACCCTCCGGGCCC	0.567			NA											49	298					6.03219e-31	8.12584e-31	0.01441	1	0
DLX3	1747	broad.mit.edu	37	17	48072147	48072147	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:48072147A>T	uc002ipy.2	-	1	442	c.216T>A	c.(214-216)AAT>AAA	p.N72K		NM_005220	NP_005211	O60479	DLX3_HUMAN	distal-less homeobox 3	72						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGCAAGCCCATTGAGATTGA	0.612			NA											48	106					0	0	0.01441	0	0
ANKFN1	162282	broad.mit.edu	37	17	54403587	54403587	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:54403587G>A	uc002iun.1	+	3	103	c.68G>A	c.(67-69)GGA>GAA	p.G23E		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	23										large_intestine(1)|ovary(1)	2						CACAGAATAGGAAGGAGATTC	0.398			NA											85	108					0	0	0.01441	0	0
HEATR6	63897	broad.mit.edu	37	17	58134604	58134604	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:58134604C>T	uc002iyk.1	-	12	1901	c.1884G>A	c.(1882-1884)AAG>AAA	p.K628K	HEATR6_uc010ddk.1_Silent_p.K167K|HEATR6_uc010wos.1_Silent_p.K460K	NM_022070	NP_071353	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	628							binding			ovary(1)|skin(1)	2	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CAGGGGCTTTCTTCCACCAAT	0.517			NA											41	248					0	0	0.00874	0	0
ACE	1636	broad.mit.edu	37	17	61555354	61555354	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:61555354G>T	uc002jau.1	+	2	334	c.312G>T	c.(310-312)CTG>CTT	p.L104L	ACE_uc010wph.1_Silent_p.L104L|ACE_uc010wpi.1_Silent_p.L104L|ACE_uc010ddu.1_5'UTR	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	104	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CCAAGGAGCTGTATGAACCGA	0.652			NA											17	31					6.94344e-10	7.97022e-10	0.006122	1	0
GH1	2688	broad.mit.edu	37	17	61995377	61995377	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:61995377G>T	uc002jdj.2	-	3	353	c.291C>A	c.(289-291)TCC>TCA	p.S97S	GH1_uc002jdi.2_Silent_p.S82S|GH1_uc002jdk.2_Intron|GH1_uc002jdl.2_Intron|GH1_uc002jdm.2_Intron|GH1_uc002jdn.2_Silent_p.S97S	NM_000515	NP_000506	P01241	SOMA_HUMAN	growth hormone 1 isoform 1	97			S -> F (in IGHD1B; reduced ability to activate the JAK/STAT pathway).		glucose transport|growth hormone receptor signaling pathway|JAK-STAT cascade|positive regulation of activation of JAK2 kinase activity|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of MAP kinase activity|positive regulation of multicellular organism growth|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|response to estradiol stimulus	extracellular space	growth factor activity|growth hormone receptor binding|hormone activity|metal ion binding|prolactin receptor binding				0						ATCCACTCACGGATTTCTGTT	0.572			NA											106	130					8.08851e-39	1.11841e-38	0.01441	1	0
PRKCA	5578	broad.mit.edu	37	17	64800011	64800011	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:64800011C>A	uc002jfp.1	+	17	1919	c.1875C>A	c.(1873-1875)AAC>AAA	p.N625K		NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	625	AGC-kinase C-terminal.				activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	GAGCAGAGAACTTTGACAAGT	0.493			NA											33	133					3.03874e-20	3.92483e-20	0.015359	1	0
ABCA8	10351	broad.mit.edu	37	17	66891114	66891114	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:66891114C>A	uc002jhp.2	-	20	2864	c.2685G>T	c.(2683-2685)CAG>CAT	p.Q895H	ABCA8_uc002jhq.2_Missense_Mutation_p.Q935H|ABCA8_uc010wqq.1_Missense_Mutation_p.Q935H|ABCA8_uc010wqr.1_Missense_Mutation_p.Q874H|ABCA8_uc002jhr.2_Missense_Mutation_p.Q935H	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	895						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					AAGCTATGTTCTGGTGCTCCA	0.378			NA											23	84					3.7963e-18	4.80049e-18	0.01892	1	0
ABCA9	10350	broad.mit.edu	37	17	67031811	67031811	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:67031811C>T	uc002jhu.2	-	7	1075	c.932G>A	c.(931-933)GGC>GAC	p.G311D	ABCA9_uc010dez.2_Missense_Mutation_p.G311D	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	311	Helical; (Potential).				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					CAAAGACAGGCCATAGAGGAG	0.383			NA											18	54					0	0	0.008871	0	0
SDK2	54549	broad.mit.edu	37	17	71394318	71394318	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:71394318G>T	uc010dfm.2	-	24	3210	c.3210C>A	c.(3208-3210)CGC>CGA	p.R1070R	SDK2_uc002jjt.3_Silent_p.R229R|SDK2_uc010dfn.2_Silent_p.R749R	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1070	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CCTGGCGCATGCGGAAGCTGG	0.627			NA											10	76					3.07112e-06	3.33023e-06	0.010729	1	0
CD300C	10871	broad.mit.edu	37	17	72540857	72540857	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:72540857C>T	uc002jky.1	-	2	652	c.291G>A	c.(289-291)CTG>CTA	p.L97L		NM_006678	NP_006669	Q08708	CLM6_HUMAN	CD300C antigen precursor	97	Extracellular (Potential).|Ig-like V-type.				cellular defense response	integral to plasma membrane	transmembrane receptor activity				0						TGAGATTCTCCAGGGTCACTG	0.552	Esophageal Squamous(66;421 1121 20537 25337 27468)		NA											45	111					0	0	0.009718	0	0
OTOP2	92736	broad.mit.edu	37	17	72926822	72926822	+	Silent	SNP	G	G	A	rs150890021	by1000genomes	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr17:72926822G>A	uc010wrp.1	+	7	1181	c.1092G>A	c.(1090-1092)ACG>ACA	p.T364T		NM_178160	NP_835454	Q7RTS6	OTOP2_HUMAN	otopetrin 2	364						integral to membrane		p.T364A(1)		ovary(3)|large_intestine(1)	4	all_lung(278;0.172)|Lung NSC(278;0.207)					AGAACCCCACGCGCACTCTGG	0.617			NA											16	112					0	0	0.00499	0	0
L3MBTL4	91133	broad.mit.edu	37	18	5969418	5969418	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:5969418G>T	uc002kmz.3	-	18	1775	c.1615C>A	c.(1615-1617)CAA>AAA	p.Q539K	L3MBTL4_uc010dkt.2_Missense_Mutation_p.Q539K|L3MBTL4_uc002kmy.3_Missense_Mutation_p.Q368K	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	539					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				CGTGCCACTTGGCTGGCCCGG	0.637	Esophageal Squamous(41;748 902 17366 28959 43175)		NA											11	84					4.68919e-08	5.2444e-08	0.008291	1	0
C18orf1	753	broad.mit.edu	37	18	13645351	13645351	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:13645351A>T	uc002ksa.2	+	7	1284	c.616A>T	c.(616-618)AGG>TGG	p.R206W	C18orf1_uc002ksb.2_Missense_Mutation_p.R188W|C18orf1_uc002kse.2_Missense_Mutation_p.R169W|C18orf1_uc002ksf.2_Missense_Mutation_p.R151W|C18orf1_uc002ksg.1_Missense_Mutation_p.R129W|C18orf1_uc002ksh.1_Missense_Mutation_p.R148W|C18orf1_uc002ksi.1_Missense_Mutation_p.R130W	NM_181481	NP_852146	O15165	CR001_HUMAN	hypothetical protein LOC753 isoform alpha 1	206	Cytoplasmic (Potential).					integral to membrane|plasma membrane				ovary(2)|skin(1)	3				READ - Rectum adenocarcinoma(73;0.0642)		AGAGTCCGTGAGGGCCCCACC	0.587			NA											46	146					0	0	0.013114	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996562	19996562	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:19996562C>A	uc002ktv.1	-	1	1317	c.1213G>T	c.(1213-1215)GCC>TCC	p.A405S		NM_172241	NP_758441	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	405	Potential.					integral to membrane				ovary(1)	1	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					AGATCTTTGGCTCGCTTTCGG	0.383			NA											36	276					6.97489e-18	8.76332e-18	0.021022	1	0
DSG3	1830	broad.mit.edu	37	18	29055815	29055815	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:29055815T>A	uc002kws.2	+	16	2701	c.2592T>A	c.(2590-2592)GAT>GAA	p.D864E	DSG3_uc002kwt.2_Missense_Mutation_p.D146E	NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	864	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TTGGTGTTGATGGTGAAGGCA	0.448			NA											27	114					0	0	0.005443	0	0
C18orf34	374864	broad.mit.edu	37	18	30554589	30554589	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:30554589C>A	uc002kxn.2	-	21	2587	c.2445G>T	c.(2443-2445)GTG>GTT	p.V815V	C18orf34_uc010xbq.1_RNA|C18orf34_uc010dme.1_Silent_p.V279V|C18orf34_uc010xbr.1_Silent_p.V839V|C18orf34_uc010dmf.1_Silent_p.V135V|C18orf34_uc002kxo.2_Silent_p.V777V|C18orf34_uc002kxp.2_Silent_p.V815V	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	815										ovary(1)	1						TGAAGAGGACCACCAGTTTGA	0.512			NA											16	43					2.35188e-11	2.76029e-11	0.006122	1	0
MBD1	4152	broad.mit.edu	37	18	47799766	47799766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:47799766C>A	uc010dow.1	-	13	1959	c.1522G>T	c.(1522-1524)GAG>TAG	p.E508*	MBD1_uc002lef.2_Intron|MBD1_uc002leg.2_Nonsense_Mutation_p.E458*|MBD1_uc010xdi.1_Nonsense_Mutation_p.E559*|MBD1_uc002leh.3_Nonsense_Mutation_p.E452*|MBD1_uc002len.2_Intron|MBD1_uc002lei.3_Nonsense_Mutation_p.E508*|MBD1_uc002lej.3_Intron|MBD1_uc002lek.3_Nonsense_Mutation_p.E459*|MBD1_uc002lel.3_Intron|MBD1_uc002lem.3_Nonsense_Mutation_p.E508*|MBD1_uc010xdj.1_Intron|MBD1_uc010xdk.1_Nonsense_Mutation_p.E533*|MBD1_uc010dox.1_Intron|MBD1_uc002leo.2_Intron	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	508					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						GGTGTCCACTCGTCCTGGGTA	0.607			NA											35	96					6.05902e-23	7.93034e-23	0.017118	1	0
ME2	4200	broad.mit.edu	37	18	48447064	48447064	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:48447064C>T	uc002ley.2	+	9	1134	c.878C>T	c.(877-879)GCA>GTA	p.A293V	ME2_uc010dpd.2_Missense_Mutation_p.A293V	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	293					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	GGTCTTCTTGCAGCACAAAAA	0.348			NA											31	98					0	0	0.010818	0	0
MEX3C	51320	broad.mit.edu	37	18	48703798	48703798	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:48703798G>A	uc002lfc.3	-	2	903	c.903C>T	c.(901-903)TCC>TCT	p.S301S		NM_016626	NP_057710	Q5U5Q3	MEX3C_HUMAN	ring finger and KH domain containing 2	301						cytoplasm|nucleus	RNA binding|zinc ion binding			lung(2)|ovary(1)|skin(1)	4		Colorectal(6;0.003)|all_epithelial(6;0.0473)		Colorectal(16;0.0175)|READ - Rectum adenocarcinoma(32;0.15)		CACGAATCATGGAGAAGTGCT	0.502			NA											27	40					0	0	0.021523	0	0
WDR7	23335	broad.mit.edu	37	18	54446673	54446673	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:54446673T>C	uc002lgk.1	+	18	3170	c.2959T>C	c.(2959-2961)TTA>CTA	p.L987L	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Silent_p.L954L	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	987										ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		TTGGAGTCAGTTAGCTGCTAT	0.403			NA											94	74					0	0	0.01441	0	0
LMAN1	3998	broad.mit.edu	37	18	57026338	57026338	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:57026338C>G	uc002lhz.2	-	1	171	c.139G>C	c.(139-141)GAG>CAG	p.E47Q	LMAN1_uc010xek.1_Missense_Mutation_p.E47Q	NM_005570	NP_005561	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1 precursor	47	Lumenal (Potential).|L-type lectin-like.				blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			skin(1)	1		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TATTTGTACTCGAAACGGCGA	0.687			NA											45	112					0	0	0.01441	0	0
SALL3	27164	broad.mit.edu	37	18	76753743	76753743	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr18:76753743A>G	uc002lmt.2	+	2	1752	c.1752A>G	c.(1750-1752)CCA>CCG	p.P584P	SALL3_uc010dra.2_Silent_p.P191P	NM_171999	NP_741996	Q9BXA9	SALL3_HUMAN	sal-like 3	584					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)	4		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCGAGTCCCCACAGTCGCTCC	0.746			NA											5	2					0	0	0.013537	0	0
RPS15	6209	broad.mit.edu	37	19	1440170	1440170	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:1440170G>A	uc002lsp.1	+	3	304	c.242G>A	c.(241-243)CGG>CAG	p.R81Q	RPS15_uc002lsq.1_Missense_Mutation_p.R88Q	NM_001018	NP_001009	P62841	RS15_HUMAN	ribosomal protein S15	81					endocrine pancreas development|ribosomal small subunit export from nucleus|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleoplasm	DNA binding|protein binding|RNA binding				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGCACCTGCGGGACATGATC	0.637	Ovarian(170;79 2680 5719 44260)		NA											4	28					0	0	0.014758	0	0
THOP1	7064	broad.mit.edu	37	19	2790467	2790467	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:2790467A>G	uc002lwj.2	+	2	220	c.65A>G	c.(64-66)AAC>AGC	p.N22S		NM_003249	NP_003240	P52888	THOP1_HUMAN	thimet oligopeptidase 1	22					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCTGTGGTAAACGACCTGCGG	0.607			NA											59	81					0	0	0.01441	0	0
MYO1F	4542	broad.mit.edu	37	19	8591385	8591385	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:8591385C>T	uc002mkg.2	-	24	2836	c.2722G>A	c.(2722-2724)GGT>AGT	p.G908S		NM_012335	NP_036467	O00160	MYO1F_HUMAN	myosin IF	908						unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(1)	3						AGGGTCCGACCGCCAACCTTG	0.677			NA											2	2					0	0	0.004672	0	0
OR1M1	125963	broad.mit.edu	37	19	9203967	9203967	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:9203967G>T	uc010xkj.1	+	1	47	c.47G>T	c.(46-48)GGA>GTA	p.G16V		NM_001004456	NP_001004456	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M,	16	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)	3						ATCCTCCTGGGACTCTCAGAA	0.507			NA											27	33					1.2476e-16	1.55751e-16	0.00632	1	0
MAN2B1	4125	broad.mit.edu	37	19	12758269	12758269	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:12758269G>C	uc002mub.2	-	22	2884	c.2808C>G	c.(2806-2808)ACC>ACG	p.T936T	MAN2B1_uc010dyv.1_Silent_p.T935T	NM_000528	NP_000519	O00754	MA2B1_HUMAN	mannosidase, alpha, class 2B, member 1	936					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			ovary(4)|central_nervous_system(2)	6						TCAAGTTCAAGGTAACGGGGG	0.577			NA											8	169					0	0	0.004482	0	0
OR7A10	390892	broad.mit.edu	37	19	14952191	14952191	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:14952191G>C	uc002mzx.1	-	1	499	c.499C>G	c.(499-501)CCC>GCC	p.P167A		NM_001005190	NP_001005190	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					GTACAAAAGGGCAGTGGCAAC	0.428			NA											37	54					0	0	0.017118	0	0
OR7A17	26333	broad.mit.edu	37	19	14991871	14991871	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:14991871G>C	uc010xob.1	-	1	297	c.297C>G	c.(295-297)ACC>ACG	p.T99T		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	99	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					AGCACATCTGGGTGATGCAGC	0.468			NA											45	50					0	0	0.01441	0	0
OR7C2	26658	broad.mit.edu	37	19	15052376	15052376	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:15052376C>T	uc010xoc.1	+	1	76	c.76C>T	c.(76-78)CTC>TTC	p.L26F		NM_012377	NP_036509	O60412	OR7C2_HUMAN	olfactory receptor, family 7, subfamily C,	26	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Ovarian(108;0.203)					CATGCAGCTTCTCCTCCATGG	0.537			NA											66	66					0	0	0.01441	0	0
PGLYRP2	114770	broad.mit.edu	37	19	15586354	15586354	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:15586354A>G	uc002nbf.3	-	2	1260	c.1127T>C	c.(1126-1128)TTC>TCC	p.F376S	PGLYRP2_uc002nbg.3_Missense_Mutation_p.F376S	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	376					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CTCACCCAGGAAGGCCTCAGT	0.517			NA											110	140					0	0	0.01441	0	0
MAST3	23031	broad.mit.edu	37	19	18254604	18254604	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:18254604T>G	uc002nhz.3	+	21	2284	c.2284T>G	c.(2284-2286)TGT>GGT	p.C762G		NM_015016	NP_055831	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase	762							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			large_intestine(2)|ovary(2)|stomach(1)	5						TGGATCCTCCTGTCAGTCATC	0.592			NA											4	37					0	0	0.009096	0	0
ZNF569	148266	broad.mit.edu	37	19	37903769	37903769	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:37903769C>A	uc002ogi.2	-	6	2349	c.1791G>T	c.(1789-1791)ATG>ATT	p.M597I	ZNF569_uc002ogh.2_Missense_Mutation_p.M438I|ZNF569_uc002ogj.2_Missense_Mutation_p.M621I	NM_152484	NP_689697	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	597	C2H2-type 15.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|skin(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TATGGCCTCTCATGTGCACAA	0.403			NA											82	79					2.96794e-49	4.18501e-49	0.01441	1	0
FCGBP	8857	broad.mit.edu	37	19	40367914	40367914	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:40367914T>C	uc002omp.3	-	29	13054	c.13046A>G	c.(13045-13047)GAG>GGG	p.E4349G		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4349						extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GCAGGTGATCTCTGTGGGCAG	0.607			NA											47	117					0	0	0.011902	0	0
CYP2A7	1549	broad.mit.edu	37	19	41386491	41386491	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:41386491C>A	uc002opm.2	-	3	928	c.386G>T	c.(385-387)CGC>CTC	p.R129L	CYP2A7_uc002opo.2_Missense_Mutation_p.R129L|CYP2A7_uc002opn.2_Missense_Mutation_p.R78L	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	129						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GATGGCAAAGCGCAGGAGCTG	0.697			NA											14	35					6.31663e-08	7.05447e-08	0.003163	1	0
FOXA3	3171	broad.mit.edu	37	19	46376130	46376130	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:46376130A>T	uc002pdr.2	+	2	1064	c.867A>T	c.(865-867)CCA>CCT	p.P289P		NM_004497	NP_004488	P55318	FOXA3_HUMAN	forkhead box A3	289					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)	1		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		TGGAGCTCCCAGGGGAGCTGA	0.607			NA											38	24					0	0	0.007835	0	0
LIG1	3978	broad.mit.edu	37	19	48620931	48620931	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:48620931G>A	uc002pia.1	-	26	2667	c.2547C>T	c.(2545-2547)CTC>CTT	p.L849L	LIG1_uc010xze.1_Silent_p.L542L|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Silent_p.L781L|LIG1_uc010xzg.1_Silent_p.L818L	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	849					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GAGAGAGGGAGAGGTCAGCGC	0.662			NA						NER					9	22					0	0	0.004482	0	0
SLC6A16	28968	broad.mit.edu	37	19	49814442	49814442	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:49814442G>A	uc002pmz.2	-	2	397	c.163C>T	c.(163-165)CGG>TGG	p.R55W	SLC6A16_uc002pna.2_Missense_Mutation_p.R55W|hsa-mir-4324|MI0015854_5'Flank	NM_014037	NP_054756	Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	55	Cytoplasmic (Potential).					integral to membrane|intracellular	neurotransmitter:sodium symporter activity			skin(2)|ovary(1)|kidney(1)	4		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		TCTGCAACCCGGGCTGCTGAA	0.542			NA											9	59					0	0	0.006214	0	0
POLD1	5424	broad.mit.edu	37	19	50905742	50905742	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:50905742A>G	uc002psb.3	+	7	846	c.790A>G	c.(790-792)AAC>GAC	p.N264D	POLD1_uc002psc.3_Missense_Mutation_p.N264D|POLD1_uc010enx.2_RNA|POLD1_uc010eny.2_Missense_Mutation_p.N264D	NM_002691	NP_002682	P28340	DPOD1_HUMAN	DNA-directed DNA polymerase delta 1	264					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		CGTCGGCTGCAACTGGCTGGA	0.667			NA						DNA_polymerases_(catalytic_subunits)					11	8					0	0	0.007413	0	0
LILRB2	10288	broad.mit.edu	37	19	54783844	54783844	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:54783844G>T	uc002qfb.2	-	4	423	c.157C>A	c.(157-159)CTT>ATT	p.L53I	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.L53I|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.L53I|LILRB2_uc010yet.1_Intron|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	53	Extracellular (Potential).|Ig-like C2-type 1.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGCTTCAAGGCTCCCCTGA	0.547			NA											147	133					1.24568e-56	1.76923e-56	0.01441	1	0
GP6	51206	broad.mit.edu	37	19	55543670	55543670	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:55543670C>G	uc002qik.2	-	3	190	c.162G>C	c.(160-162)GTG>GTC	p.V54V	GP6_uc002qil.2_Silent_p.V54V|GP6_uc010esq.2_Silent_p.V54V|RDH13_uc010esr.1_Intron	NM_016363	NP_057447	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet) isoform 2	54	Ig-like C2-type 1.|Extracellular (Potential).				enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GGTACAGGTCCACGCCCGGAG	0.652			NA											52	44					0	0	0.01441	0	0
NLRP8	126205	broad.mit.edu	37	19	56490839	56490839	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:56490839C>A	uc002qmh.2	+	9	3027	c.2956C>A	c.(2956-2958)CTG>ATG	p.L986M	NLRP8_uc010etg.2_Missense_Mutation_p.L967M	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	986	LRR 6.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCTGAGACATCTGGACTTGAG	0.488			NA											97	94					8.92586e-32	1.20861e-31	0.01441	1	0
C2orf48	348738	broad.mit.edu	37	2	10350487	10350487	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:10350487G>A	uc002rai.1	+	4	533	c.244G>A	c.(244-246)GCC>ACC	p.A82T		NM_182626	NP_872432	Q96LS8	CB048_HUMAN	hypothetical protein LOC348738	82											0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		GAGAAGCCCAGCCCTCATTGT	0.522			NA											57	99					0	0	0.01441	0	0
WDR35	57539	broad.mit.edu	37	2	20153619	20153619	+	Missense_Mutation	SNP	C	C	A	rs146380332		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:20153619C>A	uc002rdi.2	-	13	1517	c.1409G>T	c.(1408-1410)CGG>CTG	p.R470L	WDR35_uc002rdj.2_Missense_Mutation_p.R459L|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Missense_Mutation_p.R35L|WDR35_uc002rdk.3_Missense_Mutation_p.R35L	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	470										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTTCGAGACCGTGTGATCTG	0.378			NA											34	204					2.80507e-11	3.28235e-11	0.012213	1	0
C2orf39	92749	broad.mit.edu	37	2	26676417	26676417	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:26676417G>T	uc002rhg.2	+	14	1993	c.1919G>T	c.(1918-1920)AGG>ATG	p.R640M		NM_145038	NP_659475	Q96MC2	CC164_HUMAN	hypothetical protein LOC92749	640											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGAAGCCTAGGTGGGCTGCG	0.567			NA											13	67					1.3612e-06	1.4884e-06	0.003163	1	0
ALK	238	broad.mit.edu	37	2	29519878	29519878	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:29519878A>G	uc002rmy.2	-	9	2600	c.1693T>C	c.(1693-1695)TCC>CCC	p.S565P		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	565	MAM 2.|Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AGCACCAAGGACACGTTTCCC	0.547			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				16	117					0	0	0.00499	0	0
HEATR5B	54497	broad.mit.edu	37	2	37302747	37302747	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:37302747G>A	uc002rpp.1	-	5	574	c.478C>T	c.(478-480)CTA>TTA	p.L160L		NM_019024	NP_061897	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	160							binding			ovary(5)|skin(2)|breast(1)	8		all_hematologic(82;0.21)				ACTTTCTGTAGACTCATTAAG	0.388			NA											48	174					0	0	0.01441	0	0
CYP1B1	1545	broad.mit.edu	37	2	38297933	38297933	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:38297933G>C	uc002rqo.2	-	4	1967	c.1564C>G	c.(1564-1566)CTC>GTC	p.L522V		NM_000104	NP_000095	Q16678	CP1B1_HUMAN	cytochrome P450, family 1, subfamily B,	522					visual perception|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			ovary(1)|central_nervous_system(1)	2		all_hematologic(82;0.21)			Estrone(DB00655)	GACTCTCTGAGAGTGACATTG	0.408			NA											54	123					0	0	0.01441	0	0
EML4	27436	broad.mit.edu	37	2	42530318	42530318	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:42530318A>G	uc002rsi.2	+	15	1978	c.1716A>G	c.(1714-1716)CGA>CGG	p.R572R	EML4_uc010fap.2_Silent_p.R514R|EML4_uc002rsj.2_Silent_p.R261R|EML4_uc010faq.2_5'UTR|EML4_uc010ynv.1_5'UTR	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	572					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						GCACATCACGAAACTTTATTT	0.348			NA	T	ALK	NSCLC								28	165					0	0	0.007291	0	0
COX7A2L	9167	broad.mit.edu	37	2	42578436	42578436	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:42578436T>A	uc002rsk.2	-	3	323	c.268A>T	c.(268-270)ACC>TCC	p.T90S	COX7A2L_uc002rsl.2_RNA	NM_004718	NP_004709	O14548	COX7R_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 2	90					respiratory electron transport chain	mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0						AGCGCCATGGTGGTCCGGTAA	0.522			NA											28	53					0	0	0.007291	0	0
THADA	63892	broad.mit.edu	37	2	43768305	43768305	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:43768305A>T	uc002rsw.3	-	21	3609	c.3257T>A	c.(3256-3258)GTG>GAG	p.V1086E	THADA_uc010far.2_Missense_Mutation_p.V355E|THADA_uc002rsx.3_Missense_Mutation_p.V1086E|THADA_uc002rsy.3_RNA|THADA_uc010fas.1_RNA|THADA_uc002rsz.2_Missense_Mutation_p.V795E|THADA_uc010fat.1_Missense_Mutation_p.V233E|THADA_uc002rta.2_Missense_Mutation_p.V796E	NM_001083953	NP_001077422	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1086							binding			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				TACCTGCTCCACCGTCAATAA	0.388			NA											34	66					0	0	0.010818	0	0
SRBD1	55133	broad.mit.edu	37	2	45616530	45616530	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:45616530G>A	uc002rus.2	-	21	2983	c.2907C>T	c.(2905-2907)CCC>CCT	p.P969P	SRBD1_uc010yoc.1_Silent_p.P488P	NM_018079	NP_060549	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	969	S1 motif.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			central_nervous_system(1)	1		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CTCTTTCTCCGGGGCCCAGTC	0.468			NA											4	134					0	0	0.009096	0	0
TTC7A	57217	broad.mit.edu	37	2	47256494	47256495	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:47256494_47256495GG>TT	uc002rvo.2	+	15	2141_2142	c.1773_1774GG>TT	c.(1771-1776)ATGGCC>ATTTCC	p.591_592MA>IS	TTC7A_uc002rvm.2_Missense_Mutation_p.557_558MA>IS|TTC7A_uc002rvn.1_Missense_Mutation_p.472_473MA>IS|TTC7A_uc010fbb.2_Missense_Mutation_p.591_592MA>IS|TTC7A_uc010fbc.2_Missense_Mutation_p.237_238MA>IS|TTC7A_uc002rvp.2_Missense_Mutation_p.472_473MA>IS|TTC7A_uc002rvq.2_Missense_Mutation_p.331_332MA>IS|TTC7A_uc002rvr.2_Missense_Mutation_p.40_41MA>IS	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	591_592	TPR 6.						binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTGTCAACATGGCCATCACCGA	0.619			NA											51	137					0	0	0.004672	0	0
RTN4	57142	broad.mit.edu	37	2	55253145	55253145	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:55253145A>G	uc002rye.2	-	3	2388	c.2090T>C	c.(2089-2091)ATT>ACT	p.I697T	RTN4_uc002ryd.2_Missense_Mutation_p.I491T|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	697	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						ATCACATGCAATAGATATATA	0.343			NA											52	107					0	0	0.01441	0	0
RTN4	57142	broad.mit.edu	37	2	55253716	55253716	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:55253716C>T	uc002rye.2	-	3	1817	c.1519G>A	c.(1519-1521)GAG>AAG	p.E507K	RTN4_uc002ryd.2_Missense_Mutation_p.E301K|RTN4_uc002ryf.2_Intron|RTN4_uc002ryg.2_Intron	NM_020532	NP_065393	Q9NQC3	RTN4_HUMAN	reticulon 4 isoform A	507	Cytoplasmic (Potential).				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			ovary(2)|large_intestine(1)	3						GTATTCTTCTCTGTTACTATT	0.353			NA											33	153					0	0	0.015359	0	0
AFTPH	54812	broad.mit.edu	37	2	64808353	64808353	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:64808353G>C	uc002sdc.2	+	7	2517	c.2485G>C	c.(2485-2487)GAT>CAT	p.D829H	AFTPH_uc002scz.2_Missense_Mutation_p.D829H|AFTPH_uc002sda.2_Intron|AFTPH_uc002sdb.2_Intron	NM_203437	NP_982261	Q6ULP2	AFTIN_HUMAN	aftiphilin protein isoform a	829	Clathrin-binding (Potential).				protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			ovary(2)	2						TCTGAACCTTGATTTCTTTGG	0.478			NA											3	30					0	0	0.004672	0	0
ANTXR1	84168	broad.mit.edu	37	2	69304605	69304605	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:69304605A>G	uc002sfg.2	+	8	983	c.627A>G	c.(625-627)CAA>CAG	p.Q209Q	ANTXR1_uc002sfe.2_Silent_p.Q209Q|ANTXR1_uc002sff.2_Silent_p.Q209Q|ANTXR1_uc002sfd.2_Silent_p.Q209Q	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	209	Extracellular (Potential).|VWFA.				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						AGGCTCTGCAAGGCATCATCC	0.488			NA							Familial_Infantile_Hemangioma				28	228					0	0	0.007291	0	0
DCTN1	1639	broad.mit.edu	37	2	74597136	74597136	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:74597136G>C	uc002skx.2	-	13	1659	c.1348C>G	c.(1348-1350)CTG>GTG	p.L450V	DCTN1_uc002skv.2_Missense_Mutation_p.L316V|DCTN1_uc002sku.2_Missense_Mutation_p.L316V|DCTN1_uc002skw.1_Missense_Mutation_p.L426V|DCTN1_uc010ffd.2_Missense_Mutation_p.L430V|DCTN1_uc002sky.2_Missense_Mutation_p.L413V	NM_004082	NP_004073	Q14203	DCTN1_HUMAN	dynactin 1 isoform 1	450	Potential.				cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			ovary(3)|skin(2)	5						TTCTCTTCCAGATTCAGGTTC	0.537			NA											52	229					0	0	0.01441	0	0
LRRTM4	80059	broad.mit.edu	37	2	77746613	77746613	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:77746613T>A	uc002snr.2	-	3	797	c.382A>T	c.(382-384)ACA>TCA	p.T128S	LRRTM4_uc002snq.2_Missense_Mutation_p.T128S|LRRTM4_uc002sns.2_Missense_Mutation_p.T128S|LRRTM4_uc002snt.2_Missense_Mutation_p.T129S	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	128	LRR 3.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		GGGTGAAATGTTTTATTGTGC	0.378			NA											25	68					0	0	0.016522	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88885469	88885469	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:88885469C>G	uc002stc.3	-	9	1742	c.1540G>C	c.(1540-1542)GAT>CAT	p.D514H		NM_004836	NP_004827	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha	514	Lumenal (Potential).				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						AGAACAGGATCCTTTTTGCGG	0.398	GBM(138;671 1851 16235 39058 45249)		NA											74	140					0	0	0.01441	0	0
INPP4A	3631	broad.mit.edu	37	2	99193584	99193584	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:99193584C>T	uc002syy.2	+	25	3172	c.2779C>T	c.(2779-2781)CAG>TAG	p.Q927*	INPP4A_uc010yvj.1_Nonsense_Mutation_p.Q888*|INPP4A_uc010yvk.1_Nonsense_Mutation_p.Q888*|INPP4A_uc002syx.2_Nonsense_Mutation_p.Q922*|INPP4A_uc010fik.2_Nonsense_Mutation_p.Q256*	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1	927					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						GGTCTTCACCCAGGCCCTGGA	0.527			NA											26	32					0	0	0.01892	0	0
AFF3	3899	broad.mit.edu	37	2	100210522	100210522	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:100210522C>T	uc002tag.2	-	14	1837	c.1601G>A	c.(1600-1602)AGG>AAG	p.R534K	AFF3_uc002taf.2_Missense_Mutation_p.R559K|AFF3_uc010fiq.1_Missense_Mutation_p.R534K|AFF3_uc010yvr.1_Missense_Mutation_p.R687K|AFF3_uc002tah.1_Missense_Mutation_p.R559K	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	534					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GTTGGCTGTCCTTGGCCTTTG	0.647			NA											131	192					0	0	0.01441	0	0
NMS	129521	broad.mit.edu	37	2	101093874	101093874	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:101093874G>A	uc002tan.1	+	5	266	c.259G>A	c.(259-261)GGG>AGG	p.G87R		NM_001011717	NP_001011717	Q5H8A3	NMS_HUMAN	neuromedin S precursor	87					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				ovary(1)	1						AGTTAAAACTGGGGTCAGTAT	0.383			NA											18	65					0	0	0.012319	0	0
IL1R1	3554	broad.mit.edu	37	2	102785058	102785058	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:102785058A>C	uc002tbq.2	+	7	974	c.656A>C	c.(655-657)GAG>GCG	p.E219A	IL1R1_uc010fix.2_Missense_Mutation_p.E219A|IL1R1_uc002tbp.2_Missense_Mutation_p.E219A|IL1R1_uc002tbr.2_Missense_Mutation_p.E219A	NM_000877	NP_000868	P14778	IL1R1_HUMAN	interleukin 1 receptor, type I precursor	219	Extracellular (Potential).				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			skin(1)	1					Anakinra(DB00026)	TTTCTTTCAGAGGAAAACAAA	0.433			NA											4	232					0	0	0.014758	0	0
SLC9A4	389015	broad.mit.edu	37	2	103141553	103141553	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:103141553G>A	uc002tbz.3	+	10	2346	c.1889G>A	c.(1888-1890)CGC>CAC	p.R630H		NM_001011552	NP_001011552	Q6AI14	SL9A4_HUMAN	solute carrier family 9 (sodium/hydrogen	630	Cytoplasmic (Potential).				regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			skin(2)|central_nervous_system(1)	3						ATTCTGATCCGCCGCCAGAAC	0.507			NA											17	320					0	0	0.007413	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460211	107460211	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:107460211C>G	uc002tdq.2	-	2	342	c.223G>C	c.(223-225)GAC>CAC	p.D75H	ST6GAL2_uc002tdr.2_Missense_Mutation_p.D75H|ST6GAL2_uc002tds.3_Missense_Mutation_p.D75H	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	75	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						TGGCGTGCGTCCAGGCCCCCA	0.692			NA											15	52					0	0	0.020292	0	0
PTPN4	5775	broad.mit.edu	37	2	120723109	120723109	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:120723109A>G	uc002tmf.1	+	25	3217	c.2446A>G	c.(2446-2448)ATA>GTA	p.I816V	PTPN4_uc010flj.1_Missense_Mutation_p.I529V|PTPN4_uc010yyr.1_Missense_Mutation_p.I449V	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	816	Tyrosine-protein phosphatase.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	GATCCAGTACATAGCCTGGCC	0.368			NA											85	106					0	0	0.01441	0	0
MYO7B	4648	broad.mit.edu	37	2	128394197	128394197	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:128394197G>C	uc002top.2	+	45	6176	c.6123G>C	c.(6121-6123)AAG>AAC	p.K2041N	MYO7B_uc002tos.1_Missense_Mutation_p.K151N|MYO7B_uc002tot.2_Missense_Mutation_p.K151N	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	2041	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TCCACCCCAAGACCAAGGTAG	0.652			NA											5	24					0	0	0.014758	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489461	133489461	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:133489461C>A	uc002ttp.2	-	17	5666	c.5292G>T	c.(5290-5292)ATG>ATT	p.M1764I	NCKAP5_uc002ttq.2_Missense_Mutation_p.M445I	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1764							protein binding				0						TTTGGGCTCTCATGGAAGAAA	0.582			NA											20	90					4.26978e-12	5.07198e-12	0.01892	1	0
NCKAP5	344148	broad.mit.edu	37	2	133547750	133547750	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:133547750A>T	uc002ttp.2	-	13	1312	c.938T>A	c.(937-939)TTG>TAG	p.L313*	NCKAP5_uc002ttq.2_Nonsense_Mutation_p.L313*	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	313							protein binding				0						AGGGCATTTCAAGGCCGATTT	0.493			NA											3	48					0	0	0.004672	0	0
LRP1B	53353	broad.mit.edu	37	2	141032165	141032165	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:141032165C>A	uc002tvj.1	-	85	13942	c.12970G>T	c.(12970-12972)GTG>TTG	p.V4324L		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4324	Extracellular (Potential).|EGF-like 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGGTGGCACACGTCTAGGAAA	0.353	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			24	46					2.98393e-07	3.30891e-07	0.016522	1	0
DPP4	1803	broad.mit.edu	37	2	162868405	162868405	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:162868405C>G	uc002ubz.2	-	20	2291	c.1730G>C	c.(1729-1731)AGC>ACC	p.S577T	DPP4_uc010fpb.2_Missense_Mutation_p.S253T	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	577	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	GCCATCAAAGCTAGCTACTAT	0.428			NA											11	223					0	0	0.010729	0	0
SCN2A	6326	broad.mit.edu	37	2	166201299	166201299	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:166201299C>A	uc002udc.2	+	16	3087	c.2797C>A	c.(2797-2799)CTG>ATG	p.L933M	SCN2A_uc002udd.2_Missense_Mutation_p.L933M|SCN2A_uc002ude.2_Missense_Mutation_p.L933M	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	933	II.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CCACTCCTTCCTGATCGTGTT	0.493			NA											63	199					3.07281e-33	4.19701e-33	0.01441	1	0
SCN9A	6335	broad.mit.edu	37	2	167168167	167168167	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:167168167C>G	uc010fpl.2	-	2	441	c.100G>C	c.(100-102)GAA>CAA	p.E34Q		NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	34						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCTTTGGGTTCCTTTGATTTT	0.468			NA											43	182					0	0	0.009718	0	0
XIRP2	129446	broad.mit.edu	37	2	168100642	168100642	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:168100642T>C	uc002udx.2	+	8	2758	c.2740T>C	c.(2740-2742)TGG>CGG	p.W914R	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.W739R|XIRP2_uc010fpq.2_Missense_Mutation_p.W692R|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	739	Xin 11.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						GCATCAAAAATGGATTTTTGA	0.368			NA											26	75					0	0	0.021523	0	0
KBTBD10	10324	broad.mit.edu	37	2	170336019	170336019	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:170336019G>T	uc010zdh.1	+	1	14	c.-44G>T	c.(-46--42)TAGGC>TATGC		BBS5_uc002uet.2_Translation_Start_Site|BBS5_uc010fpw.2_Translation_Start_Site	NM_152384	NP_689597	O60662	KBTBA_HUMAN	Bardet-Biedl syndrome 5						striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						GACGCAGCTAGGCCTGCACGG	0.662			NA											7	25					2.0095e-06	2.18812e-06	0.001984	1	0
TLK1	9874	broad.mit.edu	37	2	171863034	171863034	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:171863034C>G	uc002ugn.2	-	17	2190	c.1718G>C	c.(1717-1719)AGA>ACA	p.R573T	TLK1_uc002ugo.2_Missense_Mutation_p.R594T|TLK1_uc002ugp.2_Missense_Mutation_p.R525T|TLK1_uc002ugq.2_RNA|TLK1_uc010zdn.1_Missense_Mutation_p.R477T	NM_012290	NP_036422	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1 isoform 1	573	Protein kinase.				cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)	1						ATTGAGATATCTTAGTGCATT	0.313			NA											3	204					0	0	0.004672	0	0
TTN	7273	broad.mit.edu	37	2	179395627	179395627	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:179395627G>T	uc010zfg.1	-	307	98235	c.98011C>A	c.(98011-98013)CCT>ACT	p.P32671T	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P26366T|TTN_uc010zfi.1_Missense_Mutation_p.P26299T|TTN_uc010zfj.1_Missense_Mutation_p.P26174T|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33598							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCACCCGAGGCTCTGGGGAT	0.483			NA											73	148					1.46168e-27	1.94891e-27	0.01441	1	0
TTN	7273	broad.mit.edu	37	2	179497651	179497651	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:179497651C>A	uc010zfg.1	-	183	35727	c.35503G>T	c.(35503-35505)GTG>TTG	p.V11835L	TTN_uc010zfh.1_Missense_Mutation_p.V5530L|TTN_uc010zfi.1_Missense_Mutation_p.V5463L|TTN_uc010zfj.1_Missense_Mutation_p.V5338L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	12762							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACCTTTCACTTTCAGATTG	0.438			NA											28	199					9.39395e-14	1.1348e-13	0.00632	1	0
TTN	7273	broad.mit.edu	37	2	179550274	179550274	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:179550274G>A	uc010zfg.1	-	125	28855	c.28631C>T	c.(28630-28632)TCT>TTT	p.S9544F	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S6205F|TTN_uc010fre.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10471							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTCTCTTAGAAATAATGTG	0.358			NA											16	27					0	0	0.006122	0	0
TTN	7273	broad.mit.edu	37	2	179639767	179639767	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:179639767G>T	uc010zfg.1	-	29	6895	c.6671C>A	c.(6670-6672)TCT>TAT	p.S2224Y	TTN_uc010zfh.1_Missense_Mutation_p.S2178Y|TTN_uc010zfi.1_Missense_Mutation_p.S2178Y|TTN_uc010zfj.1_Missense_Mutation_p.S2178Y|TTN_uc002unb.2_Missense_Mutation_p.S2224Y|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2224							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTCTGTCAGAGTGCATCCT	0.398			NA											44	85					1.61572e-30	2.17278e-30	0.010771	1	0
DNAH7	56171	broad.mit.edu	37	2	196620908	196620908	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:196620908T>C	uc002utj.3	-	62	11636	c.11535A>G	c.(11533-11535)AAA>AAG	p.K3845K	DNAH7_uc002uti.3_Silent_p.K328K	NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3845					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						TGCCAAGTGGTTTAAGGCTTG	0.393			NA											4	130					0	0	0.009096	0	0
HECW2	57520	broad.mit.edu	37	2	197182014	197182014	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:197182014G>T	uc002utm.1	-	10	2601	c.2418C>A	c.(2416-2418)GAC>GAA	p.D806E	HECW2_uc002utl.1_Missense_Mutation_p.D450E	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	806	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGAGAGCCTCGTCCACCCTCT	0.522			NA											15	43					1.5739e-10	1.82805e-10	0.004007	1	0
HECW2	57520	broad.mit.edu	37	2	197184122	197184122	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:197184122C>G	uc002utm.1	-	9	1675	c.1492G>C	c.(1492-1494)GAT>CAT	p.D498H	HECW2_uc002utl.1_Missense_Mutation_p.D142H	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	498					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						CTTCCATCATCAGCTCTGGAT	0.512			NA											3	65					0	0	0.004672	0	0
HECW2	57520	broad.mit.edu	37	2	197298062	197298062	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:197298062T>A	uc002utm.1	-	2	269	c.86A>T	c.(85-87)CAG>CTG	p.Q29L		NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	29					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GGCAAGGCTCTGGAGGTTCTC	0.592			NA											46	145					0	0	0.01441	0	0
RFTN2	130132	broad.mit.edu	37	2	198482528	198482528	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:198482528A>G	uc002uuo.3	-	6	1448	c.1046T>C	c.(1045-1047)ATT>ACT	p.I349T		NM_144629	NP_653230	Q52LD8	RFTN2_HUMAN	raftlin family member 2	349						plasma membrane					0						GCTCACCTCAATAACAGTCCA	0.303			NA											21	81					0	0	0.014323	0	0
GPR1	2825	broad.mit.edu	37	2	207041754	207041754	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:207041754G>T	uc002vbl.3	-	3	604	c.218C>A	c.(217-219)ACT>AAT	p.T73N	GPR1_uc010fue.2_Missense_Mutation_p.T73N|GPR1_uc010fuf.2_Missense_Mutation_p.T73N	NM_005279	NP_005270	P46091	GPR1_HUMAN	G protein-coupled receptor 1	73	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity				0		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		GAACCACAGAGTGGTGACTGT	0.468			NA											13	308					9.31168e-06	1.00142e-05	0.016723	1	0
DYTN	391475	broad.mit.edu	37	2	207527696	207527696	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:207527696G>T	uc002vbr.1	-	11	1681	c.1564C>A	c.(1564-1566)CTG>ATG	p.L522M		NM_001093730	NP_001087199	A2CJ06	DYTN_HUMAN	dystrotelin	522	Potential.					plasma membrane	zinc ion binding			ovary(1)|central_nervous_system(1)	2				LUSC - Lung squamous cell carcinoma(261;0.082)|Epithelial(149;0.129)|Lung(261;0.153)		TCTTCCTCCAGCTCATCCTTT	0.463			NA											115	221					3.45881e-44	4.82511e-44	0.01441	1	0
FASTKD2	22868	broad.mit.edu	37	2	207635937	207635937	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:207635937G>C	uc002vbu.2	+	4	1323	c.913G>C	c.(913-915)GAA>CAA	p.E305Q	FASTKD2_uc002vbv.2_Missense_Mutation_p.E305Q|FASTKD2_uc002vbx.2_Missense_Mutation_p.E305Q|FASTKD2_uc002vbw.1_Missense_Mutation_p.E305Q	NM_001136193	NP_001129665	Q9NYY8	FAKD2_HUMAN	FAST kinase domains 2	305					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			ovary(2)|skin(1)	3				LUSC - Lung squamous cell carcinoma(261;0.0718)|Epithelial(149;0.119)|Lung(261;0.138)		TTGGAAAATAGAAGATGTCTT	0.259			NA											16	43					0	0	0.00499	0	0
PIKFYVE	200576	broad.mit.edu	37	2	209141468	209141468	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:209141468G>T	uc002vcz.2	+	4	513	c.355G>T	c.(355-357)GGT>TGT	p.G119C	PIKFYVE_uc010fun.1_Translation_Start_Site|PIKFYVE_uc002vcy.1_Missense_Mutation_p.G119C|PIKFYVE_uc002vcv.2_Intron|PIKFYVE_uc002vcw.2_Missense_Mutation_p.G119C|PIKFYVE_uc002vcx.2_Intron	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	119					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TACCTTTGGAGGTCATGACCC	0.428			NA											48	118					2.13384e-23	2.80223e-23	0.01441	1	0
CXCR2P1	3580	broad.mit.edu	37	2	218925700	218925700	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:218925700A>T	uc002vgx.2	-	1	314	c.21T>A	c.(19-21)ATT>ATA	p.I7I	RUFY4_uc002vgw.2_Intron	NR_002712				Homo sapiens interleukin 8 receptor, beta pseudogene, mRNA (cDNA clone IMAGE:5450999), with apparent retained intron.												0						TGGCATGGACAATGGCCAGGT	0.537			NA											6	12					0	0	0.001984	0	0
RHBDD1	84236	broad.mit.edu	37	2	227731981	227731981	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:227731981G>A	uc002voi.2	+	3	634	c.513G>A	c.(511-513)CCG>CCA	p.P171P	RHBDD1_uc010fxc.2_Silent_p.P171P	NM_032276	NP_115652	Q8TEB9	RHBD1_HUMAN	rhomboid domain containing 1	171						integral to membrane	serine-type endopeptidase activity			ovary(1)	1		Renal(207;0.023)|all_lung(227;0.13)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;1.47e-11)|all cancers(144;1.52e-08)|Lung(261;0.0128)|LUSC - Lung squamous cell carcinoma(224;0.0175)		TTCCTGTACCGAACAGATTTG	0.398			NA											54	261					0	0	0.01441	0	0
ALPP	250	broad.mit.edu	37	2	233245175	233245175	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:233245175C>T	uc002vsq.2	+	7	1003	c.838C>T	c.(838-840)CTG>TTG	p.L280L	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	280						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCAGGCTTCCCTGGACCCGTC	0.627			NA											8	247					0	0	0.010729	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951264	235951264	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:235951264C>T	uc002vvp.2	+	4	2244	c.1851C>T	c.(1849-1851)ATC>ATT	p.I617I	SH3BP4_uc010fym.2_Silent_p.I617I|SH3BP4_uc002vvq.2_Silent_p.I617I	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	617					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AAAGTGCCATCAAGCCTTCCG	0.547			NA											8	93					0	0	0.00308	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741438	242741438	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:242741438T>C	uc002wcj.1	+	3	493	c.362T>C	c.(361-363)TTC>TCC	p.F121S		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	121	Lumenal (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CACCTGAGGTTCAACCTGCCT	0.667			NA											14	25					0	0	0.020292	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242742789	242742789	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:242742789C>G	uc002wcj.1	+	4	536	c.405C>G	c.(403-405)TTC>TTG	p.F135L		NM_022134	NP_071417	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	135	Lumenal (Potential).				biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity				0		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		ACGACACCTTCTACTTCTCCA	0.667			NA											7	18					0	0	0.00308	0	0
NRSN2	80023	broad.mit.edu	37	20	334097	334097	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:334097G>A	uc002wdi.3	+	4	971	c.433G>A	c.(433-435)GAC>AAC	p.D145N	NRSN2_uc002wdj.2_RNA|NRSN2_uc002wdl.2_Intron	NM_024958	NP_079234	Q9GZP1	NRSN2_HUMAN	neurensin 2	145						integral to membrane|plasma membrane|transport vesicle					0		all_cancers(10;0.0834)				GCTGAGCCAGGACACCAAGGC	0.632			NA											6	112					0	0	0.00308	0	0
ZNF343	79175	broad.mit.edu	37	20	2464027	2464027	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:2464027C>A	uc002wge.1	-	6	2068	c.1580G>T	c.(1579-1581)GGG>GTG	p.G527V	ZNF343_uc010gao.1_Missense_Mutation_p.G527V|ZNF343_uc002wgd.1_Missense_Mutation_p.G437V	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	527	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AAAGCCTCGCCCACATTCCCT	0.512			NA											47	95					2.40228e-13	2.89752e-13	0.013114	1	0
C20orf194	25943	broad.mit.edu	37	20	3340199	3340199	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:3340199C>T	uc002wii.2	-	7	705	c.654G>A	c.(652-654)AAG>AAA	p.K218K	C20orf194_uc002wik.2_5'UTR|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	218											0						TAGGATCCATCTTGCTGTAGA	0.373			NA											6	79					0	0	0.001168	0	0
ATRN	8455	broad.mit.edu	37	20	3529820	3529820	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:3529820C>A	uc002wim.2	+	6	1037	c.947C>A	c.(946-948)CCT>CAT	p.P316H	ATRN_uc002wil.2_Missense_Mutation_p.P316H	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	316	Extracellular (Potential).				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						TTATTAGGTCCTGGATGTTCA	0.333			NA											62	119					1.80625e-27	2.40425e-27	0.01441	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3672716	3672716	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:3672716C>A	uc002wja.2	-	16	4164	c.4164G>T	c.(4162-4164)ACG>ACT	p.T1388T	SIGLEC1_uc002wjb.1_Silent_p.T27T|SIGLEC1_uc002wiz.3_Silent_p.T1388T	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1388	Ig-like C2-type 14.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						CCCCGCTGCTCGTGGCCAGCA	0.617			NA											5	35					0.000602214	0.000627841	0.014758	1	0
SSTR4	6754	broad.mit.edu	37	20	23016252	23016252	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:23016252G>T	uc002wsr.2	+	1	196	c.132G>T	c.(130-132)GCG>GCT	p.A44A		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	44	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					acgcgcgggcggcgggcATGG	0.562	Esophageal Squamous(15;850 1104 16640)		NA											18	32					9.16793e-09	1.04018e-08	0.00499	1	0
C20orf185	359710	broad.mit.edu	37	20	31661396	31661396	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:31661396G>T	uc002wym.1	+	15	1416	c.1416G>T	c.(1414-1416)CTG>CTT	p.L472L		NM_182658	NP_872599	P59826	LPLC3_HUMAN	antimicrobial peptide RYA3 precursor	472					innate immune response	cytoplasm|extracellular region	lipid binding|protein binding			ovary(4)	4						CTGTTGTGCTGACCGTGGCAT	0.557			NA											34	116					9.8876e-21	1.27919e-20	0.021022	1	0
C20orf186	149954	broad.mit.edu	37	20	31680430	31680430	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:31680430A>T	uc010zue.1	+	9	1325	c.1310A>T	c.(1309-1311)CAG>CTG	p.Q437L		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	437						cytoplasm|extracellular region	lipid binding				0						CTGCAGAAGCAGCATGCTCTA	0.592			NA											64	131					0	0	0.01441	0	0
EPB41L1	2036	broad.mit.edu	37	20	34802331	34802331	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:34802331C>G	uc002xfb.2	+	17	2408	c.2237C>G	c.(2236-2238)TCC>TGC	p.S746C	EPB41L1_uc002xeu.2_Intron|EPB41L1_uc010zvo.1_Intron|EPB41L1_uc002xev.2_Missense_Mutation_p.S745C|EPB41L1_uc002xew.2_Missense_Mutation_p.S637C|EPB41L1_uc002xex.2_Missense_Mutation_p.S566C|EPB41L1_uc002xey.2_Intron|EPB41L1_uc002xez.2_Intron|EPB41L1_uc010gfq.2_Missense_Mutation_p.S844C	NM_012156	NP_036288	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	746	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			ovary(2)|pancreas(1)	3	Breast(12;0.0239)					ACCACTCCCTCCATCACCACG	0.582			NA											3	90					0	0	0.004672	0	0
EMILIN3	90187	broad.mit.edu	37	20	39990391	39990391	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:39990391G>T	uc002xjy.1	-	4	2042	c.1818C>A	c.(1816-1818)AGC>AGA	p.S606R		NM_052846	NP_443078	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	606						proteinaceous extracellular matrix				ovary(1)	1		Myeloproliferative disorder(115;0.00425)				CAGAGTACTGGCTGACAGAGT	0.582			NA											62	105					3.00472e-47	4.22927e-47	0.01441	1	0
PIGT	51604	broad.mit.edu	37	20	44047576	44047576	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:44047576A>T	uc002xoh.1	+	3	523	c.450A>T	c.(448-450)ACA>ACT	p.T150T	PIGT_uc010ghb.1_Silent_p.T140T|PIGT_uc010zwt.1_Intron|PIGT_uc010ghd.1_Missense_Mutation_p.Q91L|PIGT_uc010ghc.1_Intron|PIGT_uc010ghe.1_Intron|PIGT_uc010ghf.1_Missense_Mutation_p.Q137L|PIGT_uc002xoj.1_Silent_p.T150T|PIGT_uc002xok.1_Silent_p.T150T|PIGT_uc010zwu.1_5'UTR|PIGT_uc002xoi.1_RNA|PIGT_uc010zwv.1_5'UTR|PIGT_uc010zww.1_Intron|PIGT_uc010zwx.1_Missense_Mutation_p.Q19L|PIGT_uc010zwy.1_Intron|PIGT_uc010zwz.1_Intron|PIGT_uc010zxa.1_Intron|PIGT_uc002xol.1_5'UTR|PIGT_uc010zxb.1_5'Flank	NM_015937	NP_057021	Q969N2	PIGT_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	150	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			pancreas(1)	1		Myeloproliferative disorder(115;0.0122)				CCACCAACACAGTCACTCCCA	0.512			NA											61	168					0	0	0.01441	0	0
WFDC11	259239	broad.mit.edu	37	20	44278014	44278014	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:44278014C>T	uc002xpa.2	-	4	320	c.125G>A	c.(124-126)TGC>TAC	p.C42Y		NM_147197	NP_671730	Q8NEX6	WFD11_HUMAN	WAP four-disulfide core domain 11 precursor	42						extracellular region					0		Myeloproliferative disorder(115;0.0122)				CTTTCCCCAGCATTCTTCAAG	0.393			NA											66	163					0	0	0.01441	0	0
SLC12A5	57468	broad.mit.edu	37	20	44671860	44671860	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:44671860C>A	uc010zxl.1	+	9	1280	c.1204C>A	c.(1204-1206)CTG>ATG	p.L402M	SLC12A5_uc010zxm.1_Intron|SLC12A5_uc002xrb.2_Missense_Mutation_p.L379M	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	402	Cytoplasmic (Potential).				potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	CTCGGTGGGCCTGGCCGATGG	0.577			NA											64	553					3.4266e-16	4.23731e-16	0.01441	1	0
DPM1	8813	broad.mit.edu	37	20	49558641	49558641	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:49558641C>T	uc002xvw.1	-	6	421	c.421G>A	c.(421-423)GAT>AAT	p.D141N	DPM1_uc002xvv.1_Missense_Mutation_p.D36N|DPM1_uc002xvx.1_RNA	NM_003859	NP_003850	O60762	DPM1_HUMAN	dolichyl-phosphate mannosyltransferase 1	141					C-terminal protein lipidation|dolichol metabolic process|dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|protein N-linked glycosylation via asparagine|protein O-linked mannosylation	dolichol-phosphate-mannose synthase complex|endoplasmic reticulum membrane|membrane fraction	dolichyl-phosphate beta-D-mannosyltransferase activity|dolichyl-phosphate-mannose-protein mannosyltransferase activity|protein binding			ovary(1)	1						GAGACAATATCAAAATTACCC	0.353			NA											9	161					0	0	0.008291	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871901	51871901	+	Missense_Mutation	SNP	G	G	A	rs139065096	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:51871901G>A	uc002xwo.2	+	2	2860	c.1904G>A	c.(1903-1905)CGC>CAC	p.R635H		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	635					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			GATTCTTTCCGCAAAAGTGAA	0.522			NA											9	156					0	0	0.004482	0	0
PHACTR3	116154	broad.mit.edu	37	20	58318161	58318161	+	Splice_Site	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:58318161G>A	uc002yau.2	+	2	586	c.119_splice	c.e2-1	p.D40_splice	PHACTR3_uc002yat.2_Splice_Site_p.D37_splice|PHACTR3_uc010zzw.1_Splice_Site|PHACTR3_uc002yav.2_Splice_Site|PHACTR3_uc002yaw.2_Splice_Site|PHACTR3_uc002yax.2_Splice_Site	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1							nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			TCGTCTTCCAGATGAGATGGA	0.587			NA											102	211					0	0	0.01441	0	0
LAMA5	3911	broad.mit.edu	37	20	60890128	60890128	+	Missense_Mutation	SNP	C	C	T	rs149325805		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr20:60890128C>T	uc002ycq.2	-	59	8070	c.8003G>A	c.(8002-8004)CGG>CAG	p.R2668Q		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2668	Potential.|Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCCTGGCCCCGCAGGCCCTC	0.706			NA											9	40					0	0	0.004482	0	0
C21orf62	56245	broad.mit.edu	37	21	34166538	34166538	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr21:34166538G>A	uc010glz.2	-	4	567	c.195C>T	c.(193-195)ACC>ACT	p.T65T	C21orf49_uc002yqs.2_Intron|C21orf49_uc002yqu.3_Intron|C21orf49_uc002yqt.2_Intron|C21orf62_uc011adt.1_Silent_p.T65T|C21orf62_uc011adu.1_Silent_p.T65T	NM_001162495	NP_001155967	Q9NYP8	CU062_HUMAN	hypothetical protein LOC56245	65										ovary(1)	1		Myeloproliferative disorder(46;0.0255)				GGGGCAGGACGGTTTTACAGT	0.537			NA											11	123					0	0	0.008291	0	0
KRTAP10-2	386679	broad.mit.edu	37	21	45970637	45970637	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr21:45970637G>C	uc002zfi.1	-	1	752	c.705C>G	c.(703-705)TGC>TGG	p.C235W	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198693	NP_941966	P60368	KR102_HUMAN	keratin associated protein 10-2	235						keratin filament				large_intestine(1)	1						ACACGGGGCGGCAGAGGAGGG	0.672			NA											59	69					0	0	0.01441	0	0
PCNT	5116	broad.mit.edu	37	21	47786561	47786561	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr21:47786561A>G	uc002zji.3	+	15	2779	c.2672A>G	c.(2671-2673)CAG>CGG	p.Q891R	PCNT_uc002zjj.2_Missense_Mutation_p.Q773R	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	891				Missing (in Ref. 1; AAD10838).	cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GCCTTCCTGCAGGAGGCCCAG	0.562			NA											8	87					0	0	0.010729	0	0
PRODH	5625	broad.mit.edu	37	22	18905888	18905888	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:18905888C>T	uc010grl.2	-	11	1382	c.1368G>A	c.(1366-1368)GAG>GAA	p.E456E	PRODH_uc002zoj.3_Silent_p.E346E|PRODH_uc002zol.3_Silent_p.E346E|PRODH_uc002zok.3_Silent_p.E456E	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	456				AE -> Q (in Ref. 7; AAC39529).	glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	CATAGCCGATCTCTGCCGCAC	0.667			NA											23	121					0	0	0.014323	0	0
LGALS2	3957	broad.mit.edu	37	22	37966600	37966600	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:37966600G>T	uc003ata.2	-	3	344	c.232C>A	c.(232-234)CCA>ACA	p.P78T		NM_006498	NP_006489	P05162	LEG2_HUMAN	lectin, galactoside-binding, soluble, 2	78	Galectin.									breast(1)|skin(1)	2	Melanoma(58;0.0574)					TCTGACCCTGGGCTGAAGCAC	0.582	GBM(193;1840 2185 13711 20676 24505)		NA											103	236					8.87708e-63	1.26769e-62	0.01441	1	0
GCAT	23464	broad.mit.edu	37	22	38212280	38212280	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:38212280G>T	uc003atz.2	+	8	1080	c.1060G>T	c.(1060-1062)GGT>TGT	p.G354C	GCAT_uc003aua.1_Missense_Mutation_p.G380C	NM_014291	NP_055106	O75600	KBL_HUMAN	glycine C-acetyltransferase precursor	354					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups				0	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGTGATGCTGGGTGATGCCCG	0.577			NA											18	115					1.67942e-08	1.89176e-08	0.006122	1	0
PLA2G6	8398	broad.mit.edu	37	22	38512182	38512182	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:38512182C>T	uc003auy.1	-	13	1915	c.1779G>A	c.(1777-1779)CCG>CCA	p.P593P	PLA2G6_uc003auz.1_Silent_p.P539P|PLA2G6_uc003ava.1_Silent_p.P593P|PLA2G6_uc003avb.2_Silent_p.P539P|PLA2G6_uc010gxk.1_RNA|PLA2G6_uc003aux.1_5'Flank	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	593					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	GGAGTTCAGCCGGCTGCCGGT	0.602			NA											5	73					0	0	0.001168	0	0
PRR5	55615	broad.mit.edu	37	22	45132764	45132764	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:45132764G>A	uc003bfb.1	+	8	1076	c.804G>A	c.(802-804)GCG>GCA	p.A268A	PRR5_uc003bew.1_Silent_p.A259A|PRR5_uc003bex.1_Silent_p.A173A|PRR5_uc010gzt.1_Silent_p.A291A|PRR5_uc010gzu.1_Silent_p.A232A|PRR5_uc003bey.1_Silent_p.A259A|PRR5_uc003bez.1_Silent_p.A173A|PRR5-ARHGAP8_uc003bfc.2_Intron|PRR5-ARHGAP8_uc003bfd.2_Intron|PRR5-ARHGAP8_uc011aqi.1_Intron|PRR5-ARHGAP8_uc011aqj.1_Intron|PRR5_uc003bfa.1_Silent_p.A161A|PRR5_uc003bfe.1_RNA|PRR5-ARHGAP8_uc003bfg.1_Intron|PRR5_uc003bfh.1_Silent_p.A167A	NM_181333	NP_851850	P85299	PRR5_HUMAN	proline rich 5 (renal) isoform 1	268					cell cycle					skin(1)	1		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		AGCACGAGGCGGAGGGCGCGG	0.711			NA											4	76					0	0	0.009096	0	0
WNT7B	7477	broad.mit.edu	37	22	46319011	46319011	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:46319011T>A	uc003bgo.2	-	4	1149	c.775A>T	c.(775-777)AGC>TGC	p.S259C	WNT7B_uc010haa.2_Missense_Mutation_p.S263C	NM_058238	NP_478679	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family,	259					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			lung(1)	1		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		TTCTGATAGCTGCGCAGCTGT	0.652			NA											48	99					0	0	0.01441	0	0
TBC1D22A	25771	broad.mit.edu	37	22	47274578	47274578	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:47274578A>G	uc003bib.2	+	5	802	c.667A>G	c.(667-669)ATC>GTC	p.I223V	TBC1D22A_uc010haf.2_Missense_Mutation_p.I193V|TBC1D22A_uc003bic.2_Missense_Mutation_p.I164V|TBC1D22A_uc003bie.2_Missense_Mutation_p.I145V|TBC1D22A_uc003bid.2_Intron|TBC1D22A_uc010hag.2_RNA|TBC1D22A_uc003bif.2_Missense_Mutation_p.I176V	NM_014346	NP_055161	Q8WUA7	TB22A_HUMAN	TBC1 domain family, member 22A	223	Rab-GAP TBC.					intracellular	protein homodimerization activity|Rab GTPase activator activity			ovary(1)	1		all_cancers(38;4.44e-05)|all_epithelial(38;0.000507)|Breast(42;0.0488)|all_lung(38;0.0682)|Ovarian(80;0.0731)|all_neural(38;0.0966)|Glioma(61;0.222)|Lung SC(80;0.236)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0347)|BRCA - Breast invasive adenocarcinoma(115;0.231)		CTGGTCCGGAATCCCTAAGCC	0.522			NA											4	191					0	0	0.014758	0	0
NCAPH2	29781	broad.mit.edu	37	22	50960175	50960175	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:50960175C>A	uc003blr.3	+	12	1128	c.1006C>A	c.(1006-1008)CCT>ACT	p.P336T	NCAPH2_uc003blv.2_Missense_Mutation_p.P336T|NCAPH2_uc010hbb.2_Missense_Mutation_p.P187T|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.P336T|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	336					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CCCAGGTAGGCCTTACTCTGT	0.642			NA											7	199					5.4927e-09	6.25913e-09	0.004482	1	0
ODF3B	440836	broad.mit.edu	37	22	50969207	50969207	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:50969207C>A	uc003bmh.2	-	6	752	c.615G>T	c.(613-615)CTG>CTT	p.L205L	TYMP_uc003bmb.3_5'Flank|TYMP_uc003bmc.3_5'Flank|TYMP_uc003bmd.3_5'Flank|TYMP_uc010hbd.2_5'Flank|TYMP_uc003bme.3_5'Flank|TYMP_uc003bmf.3_5'Flank|TYMP_uc011arz.1_5'Flank|ODF3B_uc003bmg.2_Missense_Mutation_p.G182C	NM_001014440	NP_001014440	A8MYP8	ODF3B_HUMAN	outer dense fiber of sperm tails 3B	205	DUF1309.										0						AAGTCCGCGCCAGAATCGTGA	0.667			NA											7	26					1.76689e-08	1.98744e-08	0.006214	1	0
GRM7	2917	broad.mit.edu	37	3	7620536	7620536	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:7620536C>T	uc003bqm.2	+	8	2217	c.1943C>T	c.(1942-1944)GCC>GTC	p.A648V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.A648V|GRM7_uc003bql.2_Missense_Mutation_p.A648V|GRM7_uc003bqn.1_Missense_Mutation_p.A231V|GRM7_uc010hch.1_Missense_Mutation_p.A159V	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	648	Helical; Name=2; (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	CTGATGATTGCCAAACCAGAT	0.473			NA											49	218					0	0	0.01441	0	0
SLC6A1	6529	broad.mit.edu	37	3	11059650	11059650	+	Silent	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:11059650T>A	uc010hdq.2	+	4	771	c.360T>A	c.(358-360)CCT>CCA	p.P120P		NM_003042	NP_003033	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter	120					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(1)|skin(1)	2		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	AGCTGGCTCCTATGTTCAAGG	0.612			NA											46	226					0	0	0.01441	0	0
ATG7	10533	broad.mit.edu	37	3	11382132	11382132	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:11382132A>G	uc003bwc.2	+	10	1020	c.903A>G	c.(901-903)GCA>GCG	p.A301A	ATG7_uc003bwd.2_Silent_p.A301A|ATG7_uc011aum.1_Silent_p.A262A	NM_006395	NP_006386	O95352	ATG7_HUMAN	APG7 autophagy 7-like isoform a	301					autophagy|cellular membrane fusion|positive regulation of protein modification process|protein lipidation|protein transport	cytoplasm	APG12 activating enzyme activity|protein homodimerization activity|ubiquitin activating enzyme activity			central_nervous_system(1)	1						GTCCTAAAGCAGTTGGATGGG	0.393			NA											14	64					0	0	0.020292	0	0
CAPN7	23473	broad.mit.edu	37	3	15288300	15288300	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:15288300G>C	uc003bzn.2	+	18	2342	c.2072G>C	c.(2071-2073)CGG>CCG	p.R691P		NM_014296	NP_055111	Q9Y6W3	CAN7_HUMAN	calpain 7	691	Domain III.				proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1						TTATCAAAACGGGTGAGAAAA	0.294			NA											15	34					0	0	0.004007	0	0
GALNTL2	117248	broad.mit.edu	37	3	16254145	16254145	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:16254145G>T	uc003car.3	+	6	1742	c.1267G>T	c.(1267-1269)GAT>TAT	p.D423Y	GALNTL2_uc003caq.3_Missense_Mutation_p.D156Y	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	423	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						CCAAAATCAGGATTCCCATTC	0.537			NA											53	111					3.19069e-20	4.11431e-20	0.01441	1	0
SLC4A7	9497	broad.mit.edu	37	3	27490147	27490147	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:27490147G>C	uc003cdv.2	-	3	328	c.257C>G	c.(256-258)TCT>TGT	p.S86C	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.S91C|SLC4A7_uc011aww.1_Missense_Mutation_p.S95C|SLC4A7_uc011awx.1_Missense_Mutation_p.S95C|SLC4A7_uc011awy.1_Missense_Mutation_p.S91C|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.S91C|SLC4A7_uc011axb.1_Missense_Mutation_p.S95C|SLC4A7_uc010hfm.2_Missense_Mutation_p.S91C|SLC4A7_uc003cdw.2_Missense_Mutation_p.S86C	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	86	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CTTACCATAAGAAGGAGATTC	0.353			NA											17	116					0	0	0.00499	0	0
TTC21A	199223	broad.mit.edu	37	3	39178787	39178787	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:39178787G>T	uc003cjc.2	+	25	3557	c.3380G>T	c.(3379-3381)CGG>CTG	p.R1127L	TTC21A_uc003cje.2_Missense_Mutation_p.R1128L|TTC21A_uc003cjd.2_Intron|TTC21A_uc011ayx.1_Missense_Mutation_p.R1079L|TTC21A_uc003cjf.2_Missense_Mutation_p.R248L	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	1127							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		ACCCAGCTGCGGCTGCTGCAG	0.612			NA											22	22					6.38683e-12	7.56386e-12	0.008361	1	0
CCRL2	9034	broad.mit.edu	37	3	46450373	46450373	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:46450373C>G	uc003cpp.3	+	2	1088	c.803C>G	c.(802-804)TCC>TGC	p.S268C	CCRL2_uc010hjg.2_Missense_Mutation_p.S280C|CCRL2_uc010hjf.2_Missense_Mutation_p.S268C	NM_003965	NP_003956	O00421	CCRL2_HUMAN	chemokine (C-C motif) receptor-like 2 isoform 1	268	Extracellular (Potential).				chemotaxis|inflammatory response	integral to plasma membrane	CCR chemokine receptor binding|chemokine receptor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)		GAACACTTCTCCCTGAGTGAC	0.463			NA											11	584					0	0	0.008291	0	0
CDC25A	993	broad.mit.edu	37	3	48207217	48207217	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:48207217G>C	uc003csh.1	-	12	1464	c.1100C>G	c.(1099-1101)TCT>TGT	p.S367C	CDC25A_uc003csi.1_Missense_Mutation_p.S327C	NM_001789	NP_001780	P30304	MPIP1_HUMAN	cell division cycle 25A isoform a	367					cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			lung(3)|kidney(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ATTCAAAACAGATGCCATCTG	0.423			NA											31	119					0	0	0.007291	0	0
DNAH1	25981	broad.mit.edu	37	3	52416404	52416404	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:52416404T>A	uc011bef.1	+	50	8135	c.7874T>A	c.(7873-7875)GTG>GAG	p.V2625E	DNAH1_uc003ddv.2_5'Flank	NM_015512	NP_056327	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	2625	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			large_intestine(3)	3				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CGAGATGATGTGAAGAAGGTC	0.572			NA											4	170					0	0	0.009096	0	0
ROBO2	6092	broad.mit.edu	37	3	77600017	77600017	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:77600017G>T	uc003dpy.3	+	8	1751	c.1108G>T	c.(1108-1110)GTG>TTG	p.V370L	ROBO2_uc003dpz.2_Missense_Mutation_p.V374L|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.V374L	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	370	Ig-like C2-type 4.|Extracellular (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TAGATGCTCAGTGTCACCAAC	0.443			NA											48	62					4.85424e-44	6.75972e-44	0.01441	1	0
HTR1F	3355	broad.mit.edu	37	3	88040798	88040798	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:88040798G>A	uc003dqr.2	+	2	1057	c.899G>A	c.(898-900)GGT>GAT	p.G300D		NM_000866	NP_000857	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F	300	Helical; Name=6; (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			ovary(3)	3	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TTAATCTTGGGTGCATTTGTA	0.368			NA											6	36					0	0	0.001984	0	0
OR5K4	403278	broad.mit.edu	37	3	98073318	98073318	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:98073318A>G	uc011bgv.1	+	1	621	c.621A>G	c.(619-621)CAA>CAG	p.Q207Q		NM_001005517	NP_001005517	A6NMS3	OR5K4_HUMAN	olfactory receptor, family 5, subfamily K,	207	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TACCAATTCAAATCTTTACCA	0.338			NA											4	75					0	0	0.009096	0	0
CBLB	868	broad.mit.edu	37	3	105378032	105378032	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:105378032G>A	uc003dwc.2	-	19	3053	c.2731C>T	c.(2731-2733)CGC>TGC	p.R911C	CBLB_uc003dwa.2_Missense_Mutation_p.R126C|CBLB_uc011bhi.1_Missense_Mutation_p.R889C	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	911	Pro-rich.|Interaction with SH3KBP1.			R->A: Reduced interaction with CD2AP and with SH3KBP1. Strongly reduced interaction with CD2AP; when associated with A-907. Strongly reduced interaction with SH3KBP1; when associated with A-904.|R -> C (in Ref. 7; CAH56175).	cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						GCAGTCCTGCGCGGTCGTGGT	0.453	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								8	106					0	0	0.004482	0	0
MYH15	22989	broad.mit.edu	37	3	108219032	108219032	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:108219032C>G	uc003dxa.1	-	5	546	c.489G>C	c.(487-489)AAG>AAC	p.K163N		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	myosin, heavy polypeptide 15	163	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(5)|central_nervous_system(2)	7						CTGATCGCCTCTTCCCTTTGT	0.463			NA											41	31					0	0	0.009718	0	0
ZNF80	7634	broad.mit.edu	37	3	113955524	113955524	+	Missense_Mutation	SNP	T	T	C	rs143330045		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:113955524T>C	uc010hqo.2	-	1	902	c.398A>G	c.(397-399)TAT>TGT	p.Y133C	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	133	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				GCTGCACTCATAGGGCTTCTC	0.537	GBM(23;986 1114 21716)		NA											8	83					0	0	0.00308	0	0
ZBTB20	26137	broad.mit.edu	37	3	114057870	114057870	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:114057870C>A	uc003ebi.2	-	5	2388	c.2208G>T	c.(2206-2208)ATG>ATT	p.M736I	ZBTB20_uc003ebj.2_Missense_Mutation_p.M663I|ZBTB20_uc010hqp.2_Missense_Mutation_p.M663I|ZBTB20_uc003ebk.2_Missense_Mutation_p.M663I|ZBTB20_uc003ebl.2_Missense_Mutation_p.M663I|ZBTB20_uc003ebm.2_Missense_Mutation_p.M663I|ZBTB20_uc003ebn.2_Missense_Mutation_p.M663I	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	736	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CAGACACATGCATCCTCATGT	0.453	NSCLC(69;748 1344 9802 11203 30933)		NA											40	73					3.68427e-32	4.99735e-32	0.010771	1	0
TMEM39A	55254	broad.mit.edu	37	3	119155826	119155826	+	Splice_Site	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:119155826C>G	uc003eck.1	-	7	1288	c.925_splice	c.e7-1	p.S309_splice	TMEM39A_uc003ecl.1_Splice_Site_p.S157_splice	NM_018266	NP_060736	Q9NV64	TM39A_HUMAN	transmembrane protein 39A							integral to membrane				ovary(1)|breast(1)	2				GBM - Glioblastoma multiforme(114;0.244)		ACTGGGTACTCTGGAAGAGAT	0.473			NA											47	169					0	0	0.013114	0	0
ILDR1	286676	broad.mit.edu	37	3	121712504	121712504	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:121712504C>A	uc003ees.2	-	7	1198	c.1092G>T	c.(1090-1092)CTG>CTT	p.L364L	ILDR1_uc003eeq.2_Silent_p.L332L|ILDR1_uc003eer.2_Silent_p.L320L|ILDR1_uc010hrg.2_Silent_p.L275L	NM_175924	NP_787120	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor	364	Cytoplasmic (Potential).					cytosol|integral to membrane|plasma membrane	receptor activity			skin(1)	1				GBM - Glioblastoma multiforme(114;0.156)		TCCCCTCCCTCAGATCCCAGG	0.597			NA											16	77					2.32078e-09	2.66008e-09	0.003163	1	0
HEG1	57493	broad.mit.edu	37	3	124739860	124739860	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:124739860A>T	uc003ehs.3	-	4	1096	c.1028T>A	c.(1027-1029)CTG>CAG	p.L343Q	HEG1_uc011bke.1_Missense_Mutation_p.L343Q	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	343	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						CAAAGATCGCAGCGTTCTCGG	0.532			NA											5	27					0	0	0.001168	0	0
COL6A6	131873	broad.mit.edu	37	3	130287011	130287011	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:130287011G>C	uc010htl.2	+	5	1995	c.1964G>C	c.(1963-1965)GGA>GCA	p.G655A		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	655	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCTCAGATTGGACCAGATCGG	0.418			NA											50	202					0	0	0.01441	0	0
EPHB1	2047	broad.mit.edu	37	3	134873067	134873067	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:134873067G>A	uc003eqt.2	+	6	1591	c.1371G>A	c.(1369-1371)CCG>CCA	p.P457P	EPHB1_uc003equ.2_Silent_p.P18P	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	457	Fibronectin type-III 2.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGCCACAGCCGGAGCAGCCCA	0.557			NA											4	219					0	0	0.009096	0	0
PIK3CB	5291	broad.mit.edu	37	3	138375084	138375084	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:138375084A>G	uc011bmq.1	-	21	2975	c.2975T>C	c.(2974-2976)ATT>ACT	p.I992T	PIK3CB_uc011bmn.1_Missense_Mutation_p.I504T|PIK3CB_uc011bmo.1_Missense_Mutation_p.I443T|PIK3CB_uc011bmp.1_Missense_Mutation_p.I579T|PIK3CB_uc003est.1_5'Flank	NM_006219	NP_006210	P42338	PK3CB_HUMAN	catalytic phosphatidylinositol 3-kinase beta	992	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			breast(2)|ovary(1)|lung(1)|skin(1)	5						CCGTCGTAAAATCAGATATGC	0.458			NA											12	41					0	0	0.016723	0	0
CLSTN2	64084	broad.mit.edu	37	3	140277665	140277665	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:140277665C>T	uc003etn.2	+	12	2197	c.2007C>T	c.(2005-2007)GCC>GCT	p.A669A		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	669	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						GCACCTTCGCCAAAACCGAAG	0.532	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			35	89					0	0	0.017118	0	0
PCOLCE2	26577	broad.mit.edu	37	3	142567171	142567171	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:142567171A>T	uc003evd.2	-	3	532	c.336T>A	c.(334-336)CCT>CCA	p.P112P		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	112	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						CAAGGGCTCCAGGCCGGAAAG	0.547			NA											51	94					0	0	0.01441	0	0
ZIC4	84107	broad.mit.edu	37	3	147108910	147108910	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:147108910C>T	uc003ewd.1	-	4	1085	c.812G>A	c.(811-813)TGC>TAC	p.C271Y	ZIC4_uc003ewc.1_Missense_Mutation_p.C201Y|ZIC4_uc011bno.1_Missense_Mutation_p.C321Y	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	271	C2H2-type 5.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GCACTTGTCGCAGCCCCGCAC	0.637			NA											18	44					0	0	0.016522	0	0
ZIC4	84107	broad.mit.edu	37	3	147108987	147108987	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:147108987G>T	uc003ewd.1	-	4	1008	c.735C>A	c.(733-735)TTC>TTA	p.F245L	ZIC4_uc003ewc.1_Missense_Mutation_p.F175L|ZIC4_uc011bno.1_Missense_Mutation_p.F295L	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	245	C2H2-type 4.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						TGCTGTTGGCGAAGCGCCGCT	0.612			NA											22	34					2.27525e-19	2.9147e-19	0.021523	1	0
AGTR1	185	broad.mit.edu	37	3	148459426	148459426	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:148459426C>A	uc003ewg.2	+	4	1050	c.604C>A	c.(604-606)CTG>ATG	p.L202M	AGTR1_uc003ewh.2_Missense_Mutation_p.L202M|AGTR1_uc003ewi.2_Missense_Mutation_p.L202M|AGTR1_uc003ewj.2_Missense_Mutation_p.L202M|AGTR1_uc003ewk.2_Missense_Mutation_p.L202M	NM_031850	NP_114038	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	202	Helical; Name=5; (Potential).				calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity				0			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	CAAAAATATACTGGGTTTCCT	0.373			NA											16	63					4.7546e-09	5.42592e-09	0.004007	1	0
SI	6476	broad.mit.edu	37	3	164712076	164712076	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:164712076C>T	uc003fei.2	-	41	4872	c.4810G>A	c.(4810-4812)GGT>AGT	p.G1604S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1604	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACAGTGCCACCATTAGCATGA	0.338			NA								HNSCC(35;0.089)			16	77					0	0	0.004007	0	0
ZBBX	79740	broad.mit.edu	37	3	167078466	167078466	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:167078466G>T	uc003fep.2	-	7	642	c.319C>A	c.(319-321)CAA>AAA	p.Q107K	ZBBX_uc011bpc.1_Missense_Mutation_p.Q107K|ZBBX_uc003feq.2_Missense_Mutation_p.Q78K	NM_024687	NP_078963	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	107						intracellular	zinc ion binding			ovary(2)	2						TATTTACCTTGAATCTGTTCC	0.269			NA											7	18					0.000157383	0.000165845	0.00308	1	0
SEC62	7095	broad.mit.edu	37	3	169693437	169693437	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:169693437G>T	uc003fgg.2	+	2	109	c.78G>T	c.(76-78)AAG>AAT	p.K26N	SEC62_uc003fgh.2_Missense_Mutation_p.K26N	NM_003262	NP_003253	Q99442	SEC62_HUMAN	translocation protein 1	26	Cytoplasmic (Potential).				cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			ovary(1)	1						CTGTGGCCAAGTATCTTCGAT	0.353			NA											35	72					6.97489e-18	8.76332e-18	0.021022	1	0
SLC7A14	57709	broad.mit.edu	37	3	170216672	170216672	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:170216672C>A	uc003fgz.2	-	4	859	c.543G>T	c.(541-543)GGG>GGT	p.G181G	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	181						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			CTTCACCTTTCCCTAGAGAGG	0.488			NA											22	61					1.96292e-10	2.26313e-10	0.010504	1	0
NLGN1	22871	broad.mit.edu	37	3	173993231	173993231	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:173993231T>C	uc003fio.1	+	5	1196	c.773T>C	c.(772-774)TTT>TCT	p.F258S	NLGN1_uc010hww.1_Missense_Mutation_p.F298S|NLGN1_uc003fip.1_Missense_Mutation_p.F258S	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	275	Extracellular (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			ATCACTGTTTTTGGATCTGGT	0.428			NA											70	89					0	0	0.01441	0	0
SENP2	59343	broad.mit.edu	37	3	185329518	185329518	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:185329518T>C	uc003fpn.2	+	8	973	c.802T>C	c.(802-804)TTT>CTT	p.F268L	SENP2_uc011brv.1_Missense_Mutation_p.F258L|SENP2_uc011brw.1_Missense_Mutation_p.F81L	NM_021627	NP_067640	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific protease 2	268					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity				0	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			AACAACTCAGTTTGTTCCAAA	0.378			NA											3	71					0	0	0.004672	0	0
C3orf65	646600	broad.mit.edu	37	3	185431229	185431229	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:185431229T>C	uc003fpr.2	+	1	190	c.14T>C	c.(13-15)CTA>CCA	p.L5P	IGF2BP2_uc010hyi.2_Intron|IGF2BP2_uc010hyj.2_Intron|IGF2BP2_uc010hyk.2_Intron|IGF2BP2_uc010hyl.2_Intron|IGF2BP2_uc003fpo.2_Intron|IGF2BP2_uc003fpp.2_Intron|IGF2BP2_uc003fpq.2_Intron|C3orf65_uc003fps.3_RNA	NR_027317				RecName: Full=Putative uncharacterized protein C3orf65;												0	all_cancers(143;1.5e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			GCAACACCACTAGATAACTGT	0.458			NA											13	64					0	0	0.016723	0	0
HRG	3273	broad.mit.edu	37	3	186395193	186395193	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:186395193C>T	uc003fqq.2	+	7	1122	c.1099C>T	c.(1099-1101)CAT>TAT	p.H367Y		NM_000412	NP_000403	P04196	HRG_HUMAN	histidine-rich glycoprotein precursor	367	His/Pro-rich (HRR).				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			ovary(1)|central_nervous_system(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		acaccatccccatgcacacca	0.095			NA											5	21					0	0	0.014758	0	0
LPP	4026	broad.mit.edu	37	3	188202445	188202445	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:188202445A>T	uc003frs.1	+	4	505	c.259A>T	c.(259-261)AAC>TAC	p.N87Y	LPP_uc011bsg.1_Missense_Mutation_p.N87Y|LPP_uc011bsi.1_Missense_Mutation_p.N87Y|LPP_uc003frt.2_Missense_Mutation_p.N87Y	NM_005578	NP_005569	Q93052	LPP_HUMAN	LIM domain containing preferred translocation	87	Pro-rich.				cell adhesion	cytoplasm|focal adhesion|nucleus	protein binding|zinc ion binding		HMGA2/LPP(161)	soft_tissue(134)|bone(27)|lung(2)|ovary(1)|breast(1)	165	all_cancers(143;1.37e-09)|all_hematologic(3;0.0429)|Ovarian(172;0.088)	all_lung(153;0.00139)|Lung NSC(153;0.00202)		GBM - Glioblastoma multiforme(93;0.00602)		TATCTCTGGAAACTTTCCTCC	0.413			NA	T	HMGA2|MLL|C12orf9	lipoma|leukemia								51	290					0	0	0.01441	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2307157	2307157	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:2307157C>T	uc003gex.1	-	8	1229	c.910G>A	c.(910-912)GCT>ACT	p.A304T	ZFYVE28_uc011bvk.1_Missense_Mutation_p.A234T|ZFYVE28_uc011bvl.1_Missense_Mutation_p.A274T|ZFYVE28_uc003gew.1_Missense_Mutation_p.A190T	NM_020972	NP_066023	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	304					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			skin(2)|ovary(1)	3						GCCAGGGCAGCGGGTCCCTGC	0.657			NA											43	63					0	0	0.00874	0	0
MSX1	4487	broad.mit.edu	37	4	4864774	4864774	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:4864774C>A	uc003gif.2	+	2	1051	c.816C>A	c.(814-816)TAC>TAA	p.Y272*		NM_002448	NP_002439	P28360	MSX1_HUMAN	msh homeobox 1	266					apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCTCGCTCTACGGTGCCTCTG	0.706			NA											7	25					5.18039e-06	5.60197e-06	0.00308	1	0
WFS1	7466	broad.mit.edu	37	4	6303098	6303099	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:6303098_6303099GG>TT	uc003giy.2	+	8	1742_1743	c.1576_1577GG>TT	c.(1576-1578)GGC>TTC	p.G526F	WFS1_uc003gix.2_Missense_Mutation_p.G526F|WFS1_uc003giz.2_Missense_Mutation_p.G344F	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	526					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GAATTTCAAGGGCACCTACTGC	0.604			NA											24	156					0	0	0.004672	0	0
SLC34A2	10568	broad.mit.edu	37	4	25677973	25677973	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:25677973G>T	uc003grr.2	+	13	1756	c.1675G>T	c.(1675-1677)GGG>TGG	p.G559W	SLC34A2_uc003grs.2_Missense_Mutation_p.G558W|SLC34A2_uc010iev.2_Missense_Mutation_p.G558W	NM_006424	NP_006415	O95436	NPT2B_HUMAN	solute carrier family 34 (sodium phosphate),	559	Helical; Name=M8; (Potential).				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			skin(3)|ovary(1)|kidney(1)	5		Breast(46;0.0503)				GGTTGGTGTCGGGGTTCCCGT	0.597			NA											30	126					1.61788e-16	2.01336e-16	0.012213	1	0
ARAP2	116984	broad.mit.edu	37	4	36149346	36149346	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:36149346T>G	uc003gsq.1	-	18	3361	c.3023A>C	c.(3022-3024)GAA>GCA	p.E1008A		NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	1008					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TGTTAAGTTTTCAGCAAATAA	0.368			NA											5	57					0	0	0.014758	0	0
LIMCH1	22998	broad.mit.edu	37	4	41687737	41687737	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:41687737G>C	uc003gvu.3	+	23	2880	c.2826G>C	c.(2824-2826)CAG>CAC	p.Q942H	LIMCH1_uc003gvv.3_Missense_Mutation_p.Q942H|LIMCH1_uc003gvw.3_Missense_Mutation_p.Q941H|LIMCH1_uc003gvx.3_Missense_Mutation_p.Q954H|LIMCH1_uc003gwe.3_Missense_Mutation_p.Q865H|LIMCH1_uc003gvy.3_Missense_Mutation_p.Q770H|LIMCH1_uc003gwa.3_Missense_Mutation_p.Q782H|LIMCH1_uc003gvz.3_Missense_Mutation_p.Q1326H|LIMCH1_uc011byu.1_Missense_Mutation_p.Q775H|LIMCH1_uc003gwc.3_Missense_Mutation_p.Q787H|LIMCH1_uc003gwd.3_Missense_Mutation_p.Q775H|LIMCH1_uc011byv.1_Missense_Mutation_p.Q692H|LIMCH1_uc011byw.1_Missense_Mutation_p.Q241H	NM_014988	NP_055803	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1 isoform a	942					actomyosin structure organization		actin binding|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4						ATCCATCCCAGAATCAGCAGA	0.428			NA											26	74					0	0	0.004656	0	0
GNPDA2	132789	broad.mit.edu	37	4	44713078	44713078	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:44713078T>C	uc003gwy.2	-	5	643	c.486A>G	c.(484-486)CTA>CTG	p.L162L	GNPDA2_uc010iga.2_Silent_p.L128L|GNPDA2_uc011bzb.1_Silent_p.L92L|GNPDA2_uc003gwz.1_Silent_p.L162L	NM_138335	NP_612208	Q8TDQ7	GNPI2_HUMAN	glucosamine-6-phosphate deaminase 2	162					N-acetylglucosamine metabolic process	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity			ovary(1)	1						TATCCATTGCTAGAGTCTTTA	0.393	Colon(54;743 1010 7604 16453 19544)		NA											41	100					0	0	0.007835	0	0
LNX1	84708	broad.mit.edu	37	4	54327087	54327087	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:54327087C>T	uc003hag.3	-	11	2430	c.2174G>A	c.(2173-2175)GGC>GAC	p.G725D	PDGFRA_uc003haa.2_Intron|LNX1_uc003haf.3_Missense_Mutation_p.G629D|LNX1_uc003hah.3_RNA	NM_001126328	NP_001119800	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1 isoform a	725						cytoplasm	zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TAAAAAAGTGCCAGGCCAAGA	0.338			NA											4	144					0	0	0.009096	0	0
KIAA1211	57482	broad.mit.edu	37	4	57181273	57181273	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:57181273G>T	uc003hbk.2	+	8	1996	c.1605G>T	c.(1603-1605)CGG>CGT	p.R535R	KIAA1211_uc010iha.2_Silent_p.R528R|KIAA1211_uc011bzz.1_Silent_p.R445R|KIAA1211_uc003hbm.1_Silent_p.R421R	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	535										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					CCATGCCCCGGCCCTACACGT	0.642			NA											18	20					7.41877e-09	8.44168e-09	0.012319	1	0
TECRL	253017	broad.mit.edu	37	4	65180482	65180482	+	Splice_Site	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:65180482C>A	uc003hcv.2	-	5	545	c.436_splice	c.e5-1	p.V146_splice	TECRL_uc003hcw.2_Splice_Site_p.V146_splice	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2						lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CCAAAAACACCTGAAAATAAA	0.328			NA											6	94					5.9392e-07	6.52147e-07	0.001168	1	0
SULT1B1	27284	broad.mit.edu	37	4	70592821	70592821	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:70592821G>C	uc003hen.2	-	8	1174	c.876C>G	c.(874-876)TTC>TTG	p.F292L		NM_014465	NP_055280	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member	292					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol					0						TCTCTGTGCGGAATTGAAGTG	0.393			NA											10	126					0	0	0.006214	0	0
MUC7	4589	broad.mit.edu	37	4	71346890	71346890	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:71346890A>C	uc011cat.1	+	4	717	c.429A>C	c.(427-429)GAA>GAC	p.E143D	MUC7_uc011cau.1_Missense_Mutation_p.E143D|MUC7_uc003hfj.2_Missense_Mutation_p.E143D|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	143	Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CTTCAAGAGAAAATGTTAACA	0.458			NA											49	261					0	0	0.01441	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73149304	73149304	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:73149304G>A	uc003hgk.1	-	22	3204	c.3167C>T	c.(3166-3168)ACC>ATC	p.T1056I		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1056					collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGGTGGCAGGGTGCTACTGCG	0.463	NSCLC(168;1941 2048 2918 13048 43078)		NA											65	129					0	0	0.01441	0	0
CXCL9	4283	broad.mit.edu	37	4	76927399	76927399	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:76927399A>T	uc003hjh.1	-	2	132	c.93T>A	c.(91-93)TGT>TGA	p.C31*		NM_002416	NP_002407	Q07325	CXCL9_HUMAN	small inducible cytokine B9 precursor	31					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			ovary(1)	1			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TGATGCAGGAACAGCGACCCT	0.428			NA											81	161					0	0	0.01441	0	0
DSPP	1834	broad.mit.edu	37	4	88534203	88534203	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:88534203G>T	uc003hqu.2	+	4	985	c.865G>T	c.(865-867)GAT>TAT	p.D289Y		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	289					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		TGGGAAAGAAGATGATCATGA	0.428			NA											17	52					6.94344e-10	7.97022e-10	0.006122	1	0
FAM190A	401145	broad.mit.edu	37	4	91230336	91230336	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:91230336G>T	uc003hsv.3	+	2	1241	c.901G>T	c.(901-903)GCT>TCT	p.A301S	FAM190A_uc003hsu.3_Missense_Mutation_p.A301S|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.A301S	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	301										large_intestine(1)|ovary(1)	2						CCTCAATTCTGCTGCTGTTAC	0.433			NA											66	181					4.46356e-37	6.1286e-37	0.01441	1	0
EMCN	51705	broad.mit.edu	37	4	101344211	101344211	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:101344211C>T	uc003hvr.2	-	7	714	c.535G>A	c.(535-537)GCA>ACA	p.A179T	EMCN_uc011cel.1_Missense_Mutation_p.A166T|EMCN_uc011cem.1_Intron	NM_016242	NP_057326	Q9ULC0	MUCEN_HUMAN	endomucin isoform 1	179	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		GAAGTGCTTGCATTTTTTCCA	0.418			NA											17	53					0	0	0.006122	0	0
EEF1A1P9	441032	broad.mit.edu	37	4	106406218	106406218	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:106406218G>A	uc003hxt.1	+	1	356	c.226G>A	c.(226-228)GAA>AAA	p.E76K		NR_003586				SubName: Full=Eukaryotic translation elongation factor 1 alpha; Flags: Fragment;												0						TGGTGAATTTGAAGCTGGTAT	0.468			NA											14	28					0	0	0.020292	0	0
DKK2	27123	broad.mit.edu	37	4	107845748	107845748	+	Silent	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:107845748T>A	uc003hyi.2	-	3	1188	c.483A>T	c.(481-483)GGA>GGT	p.G161G	DKK2_uc010ilw.1_RNA|DKK2_uc003hyj.1_Silent_p.G161G	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	161					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GATTCTGCCATCCCAAGTCAT	0.418			NA											45	148					0	0	0.013114	0	0
LEF1	51176	broad.mit.edu	37	4	109088767	109088767	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:109088767T>C	uc003hyt.1	-	1	812	c.157A>G	c.(157-159)ATC>GTC	p.I53V	LEF1_uc011cfj.1_5'Flank|LEF1_uc011cfk.1_5'Flank|LEF1_uc003hyu.1_Missense_Mutation_p.I53V|LEF1_uc003hyv.1_Missense_Mutation_p.I53V|LEF1_uc010imb.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	53	CTNNB1-binding (By similarity).				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		GAAGACTTGATGTCAGCTAAA	0.587			NA											36	143					0	0	0.021022	0	0
ENPEP	2028	broad.mit.edu	37	4	111436540	111436540	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:111436540C>T	uc003iab.3	+	8	1793	c.1451C>T	c.(1450-1452)TCT>TTT	p.S484F		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase	484	Extracellular (Potential).				cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TAGGGATCTTCTATTTTGAGA	0.299			NA											20	53					0	0	0.00632	0	0
C4orf21	55345	broad.mit.edu	37	4	113461166	113461166	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:113461166C>T	uc003iau.2	-	27	6236	c.6025G>A	c.(6025-6027)GTA>ATA	p.V2009I	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Missense_Mutation_p.V467I	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	831						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		CTTGTCCTTACACAGGACAGA	0.403			NA											5	32					0	0	0.014758	0	0
NDST4	64579	broad.mit.edu	37	4	115997379	115997379	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:115997379C>T	uc003ibu.2	-	2	1493	c.814G>A	c.(814-816)GGC>AGC	p.G272S	NDST4_uc010imw.2_Intron	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	272	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		AAGTTGTTGCCAAAAAGTACT	0.448			NA											40	139					0	0	0.00623	0	0
KIAA1109	84162	broad.mit.edu	37	4	123165092	123165092	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:123165092C>T	uc003ieh.2	+	29	4871	c.4826C>T	c.(4825-4827)CCA>CTA	p.P1609L	KIAA1109_uc003iek.2_Missense_Mutation_p.P228L	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1609					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						CTGGATCAACCAGTGTCCCAG	0.408			NA											14	91					0	0	0.016723	0	0
MFSD8	256471	broad.mit.edu	37	4	128842683	128842683	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:128842683G>A	uc003ifp.2	-	12	1509	c.1346C>T	c.(1345-1347)CCT>CTT	p.P449L	MFSD8_uc011cgu.1_Missense_Mutation_p.P404L|MFSD8_uc011cgv.1_3'UTR	NM_152778	NP_689991	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing	449	Cytoplasmic (Potential).				cell death|transmembrane transport	integral to membrane|lysosomal membrane				ovary(1)|liver(1)	2						GCTTACCTGAGGTTTTGGTCC	0.378			NA											33	62					0	0	0.013726	0	0
PRMT10	90826	broad.mit.edu	37	4	148559746	148559746	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:148559746T>C	uc003ilc.2	-	12	2617	c.2475A>G	c.(2473-2475)GGA>GGG	p.G825G	PRMT10_uc003ilb.2_Silent_p.G469G|PRMT10_uc003ild.2_Silent_p.G712G	NM_138364	NP_612373	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10	825						cytoplasm	binding|protein methyltransferase activity			ovary(1)|central_nervous_system(1)	2						CAAGTTCCTCTCCCATTTCAA	0.408			NA											36	152					0	0	0.021022	0	0
LRBA	987	broad.mit.edu	37	4	151765810	151765810	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:151765810C>G	uc010ipj.2	-	27	4935	c.4461G>C	c.(4459-4461)AAG>AAC	p.K1487N	LRBA_uc003ilt.3_Missense_Mutation_p.K146N|LRBA_uc003ilu.3_Missense_Mutation_p.K1487N	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1487						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					GTATACTTACCTTCGCTGCAG	0.323			NA											21	45					0	0	0.01892	0	0
ANP32C	23520	broad.mit.edu	37	4	165118750	165118750	+	Silent	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:165118750T>A	uc011cjk.1	-	1	114	c.114A>T	c.(112-114)ACA>ACT	p.T38T	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	38											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		CAAATTCATCTGTGAGGGCTT	0.458			NA											52	223					0	0	0.01441	0	0
DDX60L	91351	broad.mit.edu	37	4	169348279	169348279	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:169348279A>T	uc003irq.3	-	14	2093	c.1872T>A	c.(1870-1872)GTT>GTA	p.V624V	DDX60L_uc003irr.1_Silent_p.V624V|DDX60L_uc003irs.1_Silent_p.V351V	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	624							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CTAACATTTCAACTCCAAATT	0.343			NA											8	14					0	0	0.00308	0	0
FAT1	2195	broad.mit.edu	37	4	187541804	187541804	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:187541804A>C	uc003izf.2	-	10	6124	c.5936T>G	c.(5935-5937)TTT>TGT	p.F1979C		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	1979	Extracellular (Potential).|Cadherin 17.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATCCTGGGTAAACTTTAGGTG	0.453	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			83	267					0	0	0.01441	0	0
TRIML2	205860	broad.mit.edu	37	4	189022242	189022242	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:189022242C>T	uc003izl.2	-	3	334	c.298G>A	c.(298-300)GAG>AAG	p.E100K	TRIML2_uc003izj.1_5'UTR|TRIML2_uc003izk.1_5'UTR|TRIML2_uc011cle.1_Missense_Mutation_p.E150K|TRIML2_uc011clf.1_Missense_Mutation_p.E150K	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	100	Potential.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TCCTCTAGCTCGGTGGCAAGC	0.413			NA											16	63					0	0	0.00499	0	0
IRX1	79192	broad.mit.edu	37	5	3600327	3600327	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:3600327C>T	uc003jde.2	+	2	1317	c.1265C>T	c.(1264-1266)GCA>GTA	p.A422V		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	422						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						GCCCCGGGGGCACTCAATGGA	0.706			NA											9	19					0	0	0.005443	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5190105	5190105	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:5190105C>T	uc003jdl.2	+	7	1207	c.1069C>T	c.(1069-1071)CAC>TAC	p.H357Y	ADAMTS16_uc003jdk.1_Missense_Mutation_p.H357Y|ADAMTS16_uc003jdj.1_Missense_Mutation_p.H357Y	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	357	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						GATAAGTCACCACGCAGACCA	0.488			NA											87	146					0	0	0.01441	0	0
ADCY2	108	broad.mit.edu	37	5	7690926	7690926	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:7690926G>T	uc003jdz.1	+	5	910	c.843G>T	c.(841-843)CTG>CTT	p.L281L	ADCY2_uc011cmo.1_Silent_p.L101L	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	281	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						TCCACAACCTGTATGTGAAGC	0.557			NA											27	83					1.17739e-12	1.40928e-12	0.005443	1	0
ADCY2	108	broad.mit.edu	37	5	7727285	7727285	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:7727285C>T	uc003jdz.1	+	14	1849	c.1782C>T	c.(1780-1782)GCC>GCT	p.A594A	ADCY2_uc011cmo.1_Silent_p.A414A	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	594	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGTACCGGGCCACGGCACTGC	0.507			NA											9	224					0	0	0.004482	0	0
BASP1	10409	broad.mit.edu	37	5	17275998	17275998	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:17275998G>A	uc003jfx.2	+	2	852	c.673G>A	c.(673-675)GTG>ATG	p.V225M		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	225					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						AACCGTAACCGTGAAAGAGTG	0.423			NA											12	62					0	0	0.003163	0	0
RXFP3	51289	broad.mit.edu	37	5	33937437	33937437	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:33937437C>A	uc003jic.1	+	1	949	c.592C>A	c.(592-594)CGG>AGG	p.R198R		NM_016568	NP_057652	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	198	Cytoplasmic (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1						AGGACACGGCCGGGGCGACTG	0.672			NA											42	64					2.61675e-31	3.53104e-31	0.013114	1	0
HMGCS1	3157	broad.mit.edu	37	5	43297159	43297159	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:43297159T>C	uc003jnr.3	-	5	891	c.684A>G	c.(682-684)GCA>GCG	p.A228A	HMGCS1_uc003jnp.3_5'Flank|HMGCS1_uc003jnq.3_Silent_p.A228A	NM_001098272	NP_001091742	Q01581	HMCS1_HUMAN	hydroxymethylglutaryl-CoA synthase 1	228					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity				0						AGCGGTCTAATGCACTGAGGT	0.413			NA											65	174					0	0	0.01441	0	0
ITGA1	3672	broad.mit.edu	37	5	52204758	52204758	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:52204758A>T	uc003jou.2	+	13	1538	c.1486A>T	c.(1486-1488)ACA>TCA	p.T496S	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.T27S	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	496	Extracellular (Potential).|FG-GAP 5.				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				TATTTTAACAACAACTGACAT	0.383			NA											48	85					0	0	0.01441	0	0
ITGA2	3673	broad.mit.edu	37	5	52351515	52351515	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:52351515A>G	uc003joy.2	+	8	1070	c.927A>G	c.(925-927)ATA>ATG	p.I309M	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Missense_Mutation_p.I233M|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	309	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GGTTTGGCATAGCAGTAAGTG	0.398			NA											24	151					0	0	0.014323	0	0
FST	10468	broad.mit.edu	37	5	52779455	52779455	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:52779455G>A	uc003jpd.2	+	3	426	c.399G>A	c.(397-399)GGG>GGA	p.G133G	FST_uc003jpc.2_Silent_p.G133G	NM_013409	NP_037541	P19883	FST_HUMAN	follistatin isoform FST344 precursor	133	Kazal-like 1.				hemopoietic progenitor cell differentiation|negative regulation of activin receptor signaling pathway|negative regulation of follicle-stimulating hormone secretion|negative regulation of transcription from RNA polymerase II promoter|positive regulation of hair follicle development	extracellular region	activin binding|protein binding|signal transducer activity				0		Ovarian(174;1.78e-06)|Lung NSC(810;3.55e-06)|Breast(144;4.08e-05)				CAGTCTGCGGGCTGGATGGGA	0.512			NA											26	61					0	0	0.01892	0	0
F2RL1	2150	broad.mit.edu	37	5	76128923	76128923	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:76128923T>A	uc003keo.2	+	2	666	c.491T>A	c.(490-492)CTC>CAC	p.L164H		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	164	Helical; Name=3; (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		TGTTCCATTCTCTTCATGACC	0.468			NA											72	237					0	0	0.01441	0	0
ARSB	411	broad.mit.edu	37	5	78135202	78135202	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:78135202G>A	uc003kfq.2	-	6	2476	c.1190C>T	c.(1189-1191)CCG>CTG	p.P397L	ARSB_uc003kfr.3_Missense_Mutation_p.P397L	NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	397					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		CACGAAGTTCGGGTCAATATT	0.428	Melanoma(169;563 1968 25780 26156 52266)		NA											24	84					0	0	0.004656	0	0
BHMT	635	broad.mit.edu	37	5	78426781	78426781	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:78426781C>A	uc003kfu.3	+	8	1168	c.1063C>A	c.(1063-1065)CTT>ATT	p.L355I	BHMT_uc011cti.1_Missense_Mutation_p.L202I	NM_001713	NP_001704	Q93088	BHMT1_HUMAN	betaine-homocysteine methyltransferase	355					protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			ovary(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	CTGGGAGAATCTTCGGATAGC	0.502			NA											110	127					1.44639e-49	2.04318e-49	0.01441	1	0
HSPA9	3313	broad.mit.edu	37	5	137909529	137909529	+	Missense_Mutation	SNP	T	T	C	rs138260125		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:137909529T>C	uc003ldf.2	-	3	259	c.151A>G	c.(151-153)ATC>GTC	p.I51V	HSPA9_uc011cyw.1_5'UTR	NM_004134	NP_004125	P38646	GRP75_HUMAN	heat shock 70kDa protein 9 precursor	51					anti-apoptosis|protein folding	cell surface|mitochondrial nucleoid	ATP binding|unfolded protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GCTCCCTTGATTGCTTCTGAT	0.373			NA											28	23					0	0	0.010818	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209511	140209511	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:140209511A>C	uc003lho.2	+	1	1862	c.1835A>C	c.(1834-1836)CAG>CCG	p.Q612P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc011dab.1_Missense_Mutation_p.Q612P	NM_018909	NP_061732	Q9UN73	PCDA6_HUMAN	protocadherin alpha 6 isoform 1 precursor	612	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TATGAGCTGCAGCCCCCGGCA	0.667			NA											3	94					0	0	0.004672	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481535	140481535	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:140481535G>C	uc003lio.2	+	1	1302	c.1302G>C	c.(1300-1302)AAG>AAC	p.K434N	uc003lin.2_Intron	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	434	Extracellular (Potential).|Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGAAAACCAAGTACAACATAA	0.562			NA											40	99					0	0	0.006999	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736176	140736176	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:140736176C>T	uc003ljq.1	+	1	1409	c.1409C>T	c.(1408-1410)TCC>TTC	p.S470F	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.S470F	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	470	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGAGGAGCCTCCATCTTATCT	0.507			NA											40	113					0	0	0.006999	0	0
SPINK7	84651	broad.mit.edu	37	5	147693664	147693664	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:147693664T>A	uc003lpd.2	+	3	146	c.89T>A	c.(88-90)GTG>GAG	p.V30E	uc003lpb.1_Intron	NM_032566	NP_115955	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7	30	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGACACAGGTGGACTGCAGC	0.468			NA											113	115					0	0	0.01441	0	0
TIMD4	91937	broad.mit.edu	37	5	156381703	156381703	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:156381703C>G	uc003lwh.2	-	2	180	c.123G>C	c.(121-123)CTG>CTC	p.L41L	TIMD4_uc010jii.2_Silent_p.L41L	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	41	Ig-like V-type.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGGATGAGTACAGACAGGGCA	0.527			NA											41	50					0	0	0.009718	0	0
FAF2	23197	broad.mit.edu	37	5	175919294	175919294	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr5:175919294G>A	uc003mej.3	+	5	497	c.444G>A	c.(442-444)GGG>GGA	p.G148G		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	148					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						AGAAATATGGGAGGGCACACC	0.488			NA											13	72					0	0	0.003163	0	0
HDGFL1	154150	broad.mit.edu	37	6	22569979	22569979	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:22569979T>A	uc003nds.2	+	1	302	c.175T>A	c.(175-177)TAC>AAC	p.Y59N		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	59	PWWP.										0	Ovarian(93;0.163)					CCTGTTCCCGTACAAGGAGTG	0.617			NA											27	76					0	0	0.005443	0	0
HIST1H1C	3006	broad.mit.edu	37	6	26056435	26056435	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:26056435C>T	uc003nfw.2	-	1	265	c.222G>A	c.(220-222)GAG>GAA	p.E74E		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	74	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TGTTGTTTTTCTCCACATCAT	0.537			NA											39	146					0	0	0.01441	0	0
HIST1H2BC	8347	broad.mit.edu	37	6	26123802	26123802	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:26123802C>G	uc003ngk.3	-	1	353	c.331G>C	c.(331-333)GCC>CCC	p.A111P	HIST1H2BC_uc003ngl.2_Missense_Mutation_p.A111P|HIST1H2AC_uc003ngm.2_5'Flank|HIST1H2AC_uc003ngn.2_5'Flank|HIST1H2AC_uc003ngo.2_5'Flank|HIST1H2AC_uc003ngp.2_5'Flank	NM_003526	NP_003517	P62807	H2B1C_HUMAN	histone cluster 1, H2bc	111					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			ovary(1)	1						TCCGACACGGCGTGCTTGGCC	0.587			NA											14	170					0	0	0.016723	0	0
BTN2A3	54718	broad.mit.edu	37	6	26431814	26431814	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:26431814C>A	uc011dkl.1	+	6	1762	c.1732C>A	c.(1732-1734)CCA>ACA	p.P578T	BTN2A3_uc011dkm.1_RNA					RecName: Full=Butyrophilin subfamily 2 member A3; Flags: Precursor;												0						ACTAGTTGTTCCACAGCTCCC	0.483			NA											86	172					3.27475e-32	4.44957e-32	0.01441	1	0
HIST1H2AH	85235	broad.mit.edu	37	6	27115128	27115128	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:27115128A>T	uc003niz.2	+	1	221	c.221A>T	c.(220-222)AAC>ATC	p.N74I	HIST1H2BK_uc003nix.1_5'Flank|hsa-mir-3143|MI0014167_5'Flank	NM_080596	NP_542163	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	74					nucleosome assembly	nucleosome|nucleus	DNA binding				0						GCCCGCGACAACAAGAAGACC	0.647			NA											32	92					0	0	0.012213	0	0
ZNF391	346157	broad.mit.edu	37	6	27368223	27368223	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:27368223C>G	uc003njf.1	+	3	592	c.74C>G	c.(73-75)TCA>TGA	p.S25*		NM_001076781	NP_001070249	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	25					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(2)|skin(1)	3						GGCCAATTATCAAGGCAAACA	0.418			NA											5	173					0	0	0.001984	0	0
HIST1H2AJ	8331	broad.mit.edu	37	6	27782453	27782453	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:27782453G>T	uc003njn.1	-	1	66	c.66C>A	c.(64-66)GCC>GCA	p.A22A	HIST1H2BM_uc003njo.2_5'Flank	NM_021066	NP_066544	Q99878	H2A1J_HUMAN	histone cluster 1, H2aj	22					nucleosome assembly	nucleosome|nucleus	DNA binding				0						ACTGAAGCCCGGCCCGAGAAG	0.622			NA											40	56					2.76378e-25	3.64782e-25	0.01441	1	0
OR11A1	26531	broad.mit.edu	37	6	29394899	29394899	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:29394899G>A	uc003nmg.2	-	1	611	c.520C>T	c.(520-522)CAC>TAC	p.H174Y		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	174	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGGTCAATGTGGTTGGGGCCA	0.547			NA											27	63					0	0	0.021523	0	0
ATF6B	1388	broad.mit.edu	37	6	32087669	32087669	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:32087669G>A	uc003nzn.2	-	9	931	c.898C>T	c.(898-900)CCA>TCA	p.P300S	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_5'Flank|ATF6B_uc003nzo.2_Missense_Mutation_p.P297S|ATF6B_uc003nzp.1_5'UTR	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	300	Cytoplasmic (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCAGGCCGTGGTAGAGAGGGA	0.607			NA											45	88					0	0	0.01441	0	0
DNAH8	1769	broad.mit.edu	37	6	38867598	38867598	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:38867598G>T	uc003ooe.1	+	60	9059	c.8459G>T	c.(8458-8460)GGT>GTT	p.G2820V		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TTGCTGGTGGGTGTTGGTGGT	0.353			NA											13	97					0.000151284	0.00016028	0.016723	1	0
ZNF318	24149	broad.mit.edu	37	6	43308638	43308638	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:43308638A>G	uc003oux.2	-	9	3463	c.3385T>C	c.(3385-3387)TTT>CTT	p.F1129L	ZNF318_uc003ouw.2_Intron	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1129					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGAACCAGAAACTCAGAGCCT	0.448			NA											8	129					0	0	0.00308	0	0
CAPN11	11131	broad.mit.edu	37	6	44140984	44140984	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:44140984G>A	uc003owt.1	+	7	730	c.692G>A	c.(691-693)GGG>GAG	p.G231E		NM_007058	NP_008989	Q9UMQ6	CAN11_HUMAN	calpain 11	231	Calpain catalytic.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)|breast(1)	2	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GCATTGTCAGGGGGCAGTACC	0.607			NA									OREG0017466	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	66	179					0	0	0.01441	0	0
CDC5L	988	broad.mit.edu	37	6	44371547	44371547	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:44371547C>A	uc003oxl.2	+	6	800	c.541C>A	c.(541-543)CGT>AGT	p.R181S		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	181	Potential.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCTTTTCAGACGTCTTGCTGC	0.353			NA											26	40					1.1804e-14	1.44148e-14	0.021523	1	0
GPR115	221393	broad.mit.edu	37	6	47682493	47682493	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:47682493C>T	uc003oza.1	+	6	1770	c.1512C>T	c.(1510-1512)GTC>GTT	p.V504V	GPR115_uc003oyz.1_Silent_p.V561V|GPR115_uc003ozb.1_Silent_p.V502V	NM_153838	NP_722580	Q8IZF3	GP115_HUMAN	G-protein coupled receptor 115 precursor	504	Helical; Name=3; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(3)|upper_aerodigestive_tract(1)|breast(1)	8						GAATATTGGTCATTTTCCGTA	0.423	GBM(22;431 510 9010 26644 32828)		NA											23	452					0	0	0.014323	0	0
DEFB112	245915	broad.mit.edu	37	6	50011359	50011359	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:50011359C>T	uc011dws.1	-	2	271	c.271G>A	c.(271-273)GAC>AAC	p.D91N		NM_001037498	NP_001032587	Q30KQ8	DB112_HUMAN	beta-defensin 112 precursor	91					defense response to bacterium	extracellular region				central_nervous_system(1)	1	Lung NSC(77;0.042)					TTATTTGGGTCCGTAGGGTCA	0.413			NA											25	106					0	0	0.004656	0	0
C6orf142	90523	broad.mit.edu	37	6	54025173	54025173	+	Missense_Mutation	SNP	T	T	A	rs142613357	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:54025173T>A	uc003pcg.3	+	5	806	c.693T>A	c.(691-693)GAT>GAA	p.D231E	C6orf142_uc003pcf.2_Missense_Mutation_p.D755E|C6orf142_uc003pch.3_Intron|C6orf142_uc011dxa.1_Missense_Mutation_p.D766E	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	231						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					AGGCACTAGATGAACCAGCCA	0.383			NA											17	49					0	0	0.00499	0	0
EYS	346007	broad.mit.edu	37	6	66204948	66204948	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:66204948G>T	uc011dxu.1	-	4	894	c.356C>A	c.(355-357)ACA>AAA	p.T119K	EYS_uc003peq.2_Missense_Mutation_p.T119K|EYS_uc003per.1_Missense_Mutation_p.T119K|EYS_uc010kaj.1_RNA	NM_001142800	NP_001136272	Q5T1H1	EYS_HUMAN	eyes shut homolog isoform 1	119					response to stimulus|visual perception	extracellular region	calcium ion binding			lung(4)|ovary(1)|skin(1)	6						ATCTTCCGTTGTGGTATTTTG	0.358			NA											45	120					1.76056e-25	2.33155e-25	0.011902	1	0
BAI3	577	broad.mit.edu	37	6	70071247	70071247	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:70071247T>A	uc003pev.3	+	29	4530	c.4082T>A	c.(4081-4083)ATG>AAG	p.M1361K	BAI3_uc010kak.2_Missense_Mutation_p.M1361K|BAI3_uc011dxx.1_Missense_Mutation_p.M567K	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1361	Cytoplasmic (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				CAGTTCAATATGAACTTAGAG	0.433			NA											33	141					0	0	0.015359	0	0
SMAP1	60682	broad.mit.edu	37	6	71562317	71562318	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:71562317_71562318GG>TT	uc003pfr.2	+	8	987_988	c.739_740GG>TT	c.(739-741)GGA>TTA	p.G247L	SMAP1_uc003pfs.2_Missense_Mutation_p.G220L|SMAP1_uc010kao.2_Missense_Mutation_p.G220L|SMAP1_uc010kap.2_Missense_Mutation_p.G237L	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	247					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						GGACATCTTTGGACCGATGATT	0.455			NA											10	281					0	0	0.004672	0	0
C6orf221	154288	broad.mit.edu	37	6	74072525	74072525	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:74072525G>A	uc003pgt.3	+	1	126	c.73G>A	c.(73-75)GGT>AGT	p.G25S		NM_001017361	NP_001017361	Q587J8	ECAT1_HUMAN	hypothetical protein LOC154288	25										skin(2)	2						GGAGGTGCTCGGTCACCTCCC	0.577			NA											22	78					0	0	0.010504	0	0
EEF1A1	1915	broad.mit.edu	37	6	74228549	74228549	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:74228549T>C	uc003phi.2	-	4	681	c.644A>G	c.(643-645)AAA>AGA	p.K215R	EEF1A1_uc003phd.2_5'Flank|EEF1A1_uc003phe.2_Missense_Mutation_p.K205R|EEF1A1_uc003phf.2_Missense_Mutation_p.K215R|EEF1A1_uc003phg.2_Missense_Mutation_p.K215R|EEF1A1_uc003phh.2_Missense_Mutation_p.K61R|EEF1A1_uc003phj.2_Missense_Mutation_p.K215R|EEF1A1_uc003phk.2_Missense_Mutation_p.K215R|EEF1A1_uc003phl.2_Intron|EEF1A1_uc003phm.1_Intron	NM_001402	NP_001393	P68104	EF1A1_HUMAN	eukaryotic translation elongation factor 1 alpha	215						cytosol|eukaryotic translation elongation factor 1 complex	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0						ACGGGTGACTTTCCATCCCTT	0.502			NA									OREG0003895|OREG0003891	type=REGULATORY REGION|Gene=EEF1A1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay|type=REGULATORY REGION|Gene=D16891|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	32	51					0	0	0.010818	0	0
IMPG1	3617	broad.mit.edu	37	6	76728444	76728444	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:76728444G>A	uc003pik.1	-	7	928	c.798C>T	c.(796-798)TCC>TCT	p.S266S		NM_001563	NP_001554	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	266	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				CCTGAAGTTGGGACTTTCCTG	0.547	Pancreas(37;839 1141 2599 26037)		NA											27	153					0	0	0.00632	0	0
TBX18	9096	broad.mit.edu	37	6	85446428	85446428	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:85446428G>C	uc003pkl.1	-	8	1799	c.1799C>G	c.(1798-1800)TCT>TGT	p.S600C	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	600					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AGATACTTGAGATGATGACAG	0.413			NA											35	58					0	0	0.013726	0	0
ZNF292	23036	broad.mit.edu	37	6	87968870	87968870	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:87968870A>T	uc003plm.3	+	8	5564	c.5523A>T	c.(5521-5523)TTA>TTT	p.L1841F		NM_015021	NP_055836	O60281	ZN292_HUMAN	zinc finger protein 292	1841	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		AGGAAATTTTAGAAGGCTTAC	0.373			NA											15	31					0	0	0.020292	0	0
GJA10	84694	broad.mit.edu	37	6	90604983	90604983	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:90604983G>T	uc011eaa.1	+	1	796	c.796G>T	c.(796-798)GTG>TTG	p.V266L		NM_032602	NP_115991	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10	266	Cytoplasmic (Potential).				synaptic transmission	connexon complex|integral to membrane	gap junction channel activity				0		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		GAAATATTCTGTGGCCCAGCA	0.413			NA											23	69					5.35356e-11	6.22728e-11	0.016522	1	0
KIAA0776	23376	broad.mit.edu	37	6	96999336	96999336	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:96999336T>A	uc003por.2	+	16	1894	c.1846T>A	c.(1846-1848)TCA>ACA	p.S616T	KIAA0776_uc010kck.2_RNA	NM_015323	NP_056138	O94874	UFL1_HUMAN	hypothetical protein LOC23376	616					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity			ovary(1)	1		all_cancers(76;5.83e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0604)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0934)		AAGTAAATTATCAGAAGAAAC	0.299			NA											5	112					0	0	0.014758	0	0
C6orf167	253714	broad.mit.edu	37	6	97597755	97597755	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:97597755C>T	uc003ppb.2	-	24	3890	c.3624G>A	c.(3622-3624)TGG>TGA	p.W1208*	C6orf167_uc011eaf.1_Nonsense_Mutation_p.W1168*	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1208					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		TGCCAAGGCCCCATTTCTGCT	0.348			NA											14	57					0	0	0.020292	0	0
MCHR2	84539	broad.mit.edu	37	6	100395759	100395759	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:100395759G>A	uc003pqh.1	-	3	586	c.271C>T	c.(271-273)CAC>TAC	p.H91Y	MCHR2_uc003pqi.1_Missense_Mutation_p.H91Y	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	91	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		GCCCATTGGTGAATAAGAAAA	0.483			NA											35	143					0	0	0.013726	0	0
SIM1	6492	broad.mit.edu	37	6	100838954	100838954	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:100838954C>A	uc003pqj.3	-	11	1791	c.1584G>T	c.(1582-1584)TGG>TGT	p.W528C	SIM1_uc010kcu.2_Missense_Mutation_p.W528C	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	528	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TATCTTCATCCCAATGACCTC	0.403			NA											20	94					1.10513e-12	1.32481e-12	0.014323	1	0
SIM1	6492	broad.mit.edu	37	6	100897259	100897259	+	Missense_Mutation	SNP	G	G	A	rs438766		TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:100897259G>A	uc003pqj.3	-	5	730	c.523C>T	c.(523-525)CTC>TTC	p.L175F	SIM1_uc010kcu.2_Missense_Mutation_p.L175F	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1	175					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CCACAGGTGAGGCCGGCGTTA	0.622			NA											4	57					0	0	0.014758	0	0
RTN4IP1	84816	broad.mit.edu	37	6	107035616	107035616	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:107035616G>A	uc003prj.2	-	7	1405	c.928C>T	c.(928-930)CGA>TGA	p.R310*	RTN4IP1_uc010kdd.2_Intron|RTN4IP1_uc003prk.2_Nonsense_Mutation_p.R210*	NM_032730	NP_116119	Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1 precursor	310						mitochondrion	oxidoreductase activity|zinc ion binding				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		ATGCCCAATCGGTCCATGTTC	0.502			NA											39	75					0	0	0.005524	0	0
HDAC2	3066	broad.mit.edu	37	6	114277837	114277837	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:114277837G>C	uc003pwd.1	-	4	586	c.586C>G	c.(586-588)CCA>GCA	p.P196A	HDAC2_uc003pwc.1_Missense_Mutation_p.P72A|HDAC2_uc003pwe.1_Missense_Mutation_p.P72A	NM_001527	NP_001518	Q92769	HDAC2_HUMAN	histone deacetylase 2	102	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			skin(2)|ovary(1)|central_nervous_system(1)	4		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	TCAAACACTGGACAATCTTCT	0.363			NA											7	55					0	0	0.00308	0	0
THEMIS	387357	broad.mit.edu	37	6	128134623	128134623	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:128134623T>A	uc003qbi.2	-	5	1482	c.1163A>T	c.(1162-1164)CAG>CTG	p.Q388L	THEMIS_uc010kfa.2_Missense_Mutation_p.Q291L|THEMIS_uc011ebt.1_Missense_Mutation_p.Q388L|THEMIS_uc010kfb.2_Missense_Mutation_p.Q353L	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	388	CABIT 2.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CACCAGAAACTGGTCCCCAAC	0.468			NA											24	81					0	0	0.01892	0	0
NMBR	4829	broad.mit.edu	37	6	142397123	142397123	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:142397123A>T	uc003qiu.2	-	3	976	c.835T>A	c.(835-837)TGG>AGG	p.W279R		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	279	Helical; Name=6; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TTTGGAAACCAACAGAAGATG	0.413			NA											38	59					0	0	0.019004	0	0
HIVEP2	3097	broad.mit.edu	37	6	143080972	143080972	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:143080972G>C	uc003qjd.2	-	9	7196	c.6453C>G	c.(6451-6453)TAC>TAG	p.Y2151*		NM_006734	NP_006725	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer	2151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GTGGGTTATGGTATAAAGCCC	0.438	Esophageal Squamous(107;843 1510 13293 16805 42198)		NA											23	90					0	0	0.016522	0	0
C6orf97	80129	broad.mit.edu	37	6	151894422	151894422	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:151894422C>A	uc003qol.2	+	6	977	c.888C>A	c.(886-888)AGC>AGA	p.S296R		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	hypothetical protein LOC80129	296											0		Ovarian(120;0.126)	BRCA - Breast invasive adenocarcinoma(37;0.111)	OV - Ovarian serous cystadenocarcinoma(155;1.48e-10)		AGGAAGTGAGCCTCCTGAAGA	0.473			NA											17	47					9.16793e-09	1.04018e-08	0.00499	1	0
MAS1	4142	broad.mit.edu	37	6	160328002	160328002	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:160328002C>G	uc003qsz.2	+	1	29	c.15C>G	c.(13-15)AAC>AAG	p.N5K		NM_002377	NP_002368	P04201	MAS_HUMAN	MAS1 oncogene	5	Extracellular (Potential).				anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			ovary(2)|lung(2)	4		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		ATGGGTCAAACGTGACATCAT	0.458			NA											5	135					0	0	0.014758	0	0
PACRG	135138	broad.mit.edu	37	6	163483243	163483243	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:163483243A>C	uc003qua.2	+	4	577	c.353A>C	c.(352-354)GAA>GCA	p.E118A	PACRG_uc003qub.2_Missense_Mutation_p.E118A|PACRG_uc003quc.2_Missense_Mutation_p.E118A	NM_152410	NP_689623	Q96M98	PACRG_HUMAN	parkin co-regulated gene protein isoform 1	118											0		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		GGGCTTTGTGAAATGACATTT	0.433			NA											22	104					0	0	0.016522	0	0
TTLL2	83887	broad.mit.edu	37	6	167754837	167754837	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr6:167754837A>T	uc003qvs.1	+	3	1537	c.1449A>T	c.(1447-1449)GCA>GCT	p.A483A	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	483					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CTGAAGCTGCACCTGCCTCCC	0.517			NA											29	112					0	0	0.009535	0	0
DGKB	1607	broad.mit.edu	37	7	14661113	14661113	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:14661113G>A	uc003ssz.2	-	14	1364	c.1177C>T	c.(1177-1179)CAA>TAA	p.Q393*	DGKB_uc011jxt.1_Nonsense_Mutation_p.Q374*|DGKB_uc003sta.2_Nonsense_Mutation_p.Q393*|DGKB_uc011jxu.1_Nonsense_Mutation_p.Q392*	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	393					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	ACTGTTGATTGTCTTTCCTGT	0.294			NA											11	21					0	0	0.008291	0	0
C7orf31	136895	broad.mit.edu	37	7	25175779	25175779	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:25175779T>C	uc003sxn.1	-	10	2146	c.1585A>G	c.(1585-1587)ATT>GTT	p.I529V	C7orf31_uc003sxm.1_Missense_Mutation_p.I371V	NM_138811	NP_620166	Q8N865	CG031_HUMAN	hypothetical protein LOC136895	529											0						GCTCTAGGAATCCAACCAAGA	0.388			NA											6	224					0	0	0.001984	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26236615	26236615	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:26236615T>G	uc003sxr.3	-	5	539	c.323A>C	c.(322-324)CAT>CCT	p.H108P	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.H96P	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	108					RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						CACAGTTACATGAGCCCCTGG	0.383			NA	T	ETV1	prostate								44	137					0	0	0.01441	0	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26236626	26236626	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:26236626T>G	uc003sxr.3	-	5	528	c.312A>C	c.(310-312)AAA>AAC	p.K104N	HNRNPA2B1_uc003sxs.3_Missense_Mutation_p.K92N	NM_031243	NP_112533	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	104	RRM 1.				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|protein binding|RNA binding|single-stranded telomeric DNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3						GAGCCCCTGGTTTTCCAGATT	0.393			NA	T	ETV1	prostate								37	116					0	0	0.00874	0	0
WIPF3	644150	broad.mit.edu	37	7	29928925	29928925	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:29928925A>T	uc003taj.1	+	6	1253	c.1253A>T	c.(1252-1254)GAC>GTC	p.D418V		NM_001080529	NP_001073998	A6NGB9	WIPF3_HUMAN	WAS/WASL interacting protein family, member 3	418										ovary(1)	1						TGTGCAGATGACTTCGAGTCT	0.443			NA											11	42					0	0	0.010729	0	0
GHRHR	2692	broad.mit.edu	37	7	31010827	31010827	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:31010827C>G	uc003tbx.2	+	5	508	c.460C>G	c.(460-462)CTC>GTC	p.L154V	GHRHR_uc003tbw.1_Missense_Mutation_p.L154V|GHRHR_uc003tby.2_Missense_Mutation_p.L90V|GHRHR_uc003tbz.2_5'UTR	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	154	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CCTGGTTGCTCTCAGGTTTGT	0.493			NA											2	7					0	0	0.004672	0	0
BMPER	168667	broad.mit.edu	37	7	34091581	34091581	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:34091581G>T	uc011kap.1	+	8	899	c.785G>T	c.(784-786)AGG>ATG	p.R262M		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	262	VWFC 4.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TGTACCTGCAGGGTAAGGCAG	0.453			NA											21	85					1.55795e-14	1.89369e-14	0.012319	1	0
POU6F2	11281	broad.mit.edu	37	7	39243834	39243834	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:39243834G>C	uc003thb.1	+	3	233	c.191G>C	c.(190-192)GGG>GCG	p.G64A	POU6F2_uc010kxo.2_Missense_Mutation_p.G56A	NM_007252	NP_009183	P78424	PO6F2_HUMAN	POU class 6 homeobox 2 isoform 1	64					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1						TGAATTCCAGGGGCTAGAGGA	0.473			NA											10	48					0	0	0.020292	0	0
HIP1	3092	broad.mit.edu	37	7	75171247	75171247	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:75171247C>A	uc003uds.1	-	29	2984	c.2943G>T	c.(2941-2943)ATG>ATT	p.M981I	HIP1_uc011kfz.1_Missense_Mutation_p.M807I	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	981	I/LWEQ.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						CCTGAGAATCCATCTCTTGGC	0.453			NA	T	PDGFRB	CMML								37	151					2.40579e-17	3.0082e-17	0.00623	1	0
SEMA3C	10512	broad.mit.edu	37	7	80387687	80387687	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:80387687C>T	uc003uhj.2	-	15	2165	c.1603G>A	c.(1603-1605)GAT>AAT	p.D535N	SEMA3C_uc011kgw.1_Missense_Mutation_p.D553N	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	535					immune response|response to drug	membrane	receptor activity			ovary(1)	1						GAATGGCCATCCCAGGCGCAA	0.532			NA											9	197					0	0	0.004482	0	0
CACNA2D1	781	broad.mit.edu	37	7	81746386	81746386	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:81746386T>A	uc003uhr.1	-	6	756	c.500A>T	c.(499-501)CAT>CTT	p.H167L		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	167	Extracellular (Potential).					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	AGTAGGAATATGGACTGCTGC	0.423			NA											6	201					0	0	0.001168	0	0
PCLO	27445	broad.mit.edu	37	7	82544499	82544499	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:82544499C>G	uc003uhx.2	-	7	13092	c.12803G>C	c.(12802-12804)GGA>GCA	p.G4268A	PCLO_uc003uhv.2_Missense_Mutation_p.G4268A|PCLO_uc010lec.2_Missense_Mutation_p.G1233A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4199					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TATGGTATTTCCTAATGTGCC	0.393			NA											6	24					0	0	0.001168	0	0
TRRAP	8295	broad.mit.edu	37	7	98533224	98533224	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:98533224A>G	uc003upp.2	+	28	4246	c.4037A>G	c.(4036-4038)GAA>GGA	p.E1346G	TRRAP_uc011kis.1_Missense_Mutation_p.E1346G|TRRAP_uc003upr.2_Missense_Mutation_p.E1038G	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1346					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TGTGAGGCTGAAGATTCAGCT	0.388			NA											38	54					0	0	0.006999	0	0
CYP3A7	1551	broad.mit.edu	37	7	99311132	99311132	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:99311132C>T	uc003uru.2	-	9	930	c.825G>A	c.(823-825)ATG>ATA	p.M275I	ZNF498_uc003urn.2_Intron|CYP3A5_uc003urs.2_Intron|CYP3A5_uc010lgg.2_Intron	NM_000765	NP_000756	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A,	275					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)	1	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					GAGAGTCAATCATCAGCTGAA	0.433			NA											20	148					0	0	0.014323	0	0
CYP3A4	1576	broad.mit.edu	37	7	99358457	99358457	+	Silent	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:99358457A>C	uc003urv.1	-	12	1505	c.1401T>G	c.(1399-1401)CCT>CCG	p.P467P	CYP3A4_uc003urw.1_Silent_p.P466P|CYP3A4_uc011kiz.1_Silent_p.P426P|CYP3A4_uc011kja.1_Silent_p.P418P|CYP3A4_uc011kjb.1_Silent_p.P317P	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	467					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTTCTTTACAAGGTTTGAAGG	0.338			NA											68	96					0	0	0.01441	0	0
SLC26A5	375611	broad.mit.edu	37	7	103017307	103017307	+	Silent	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:103017307A>T	uc003vbz.2	-	19	2225	c.1989T>A	c.(1987-1989)ATT>ATA	p.I663I	SLC26A5_uc003vbt.1_Silent_p.I663I|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.I631I|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	663	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						ATTCTTTTACAATCTGTAATA	0.323			NA											28	100					0	0	0.00632	0	0
RELN	5649	broad.mit.edu	37	7	103155820	103155820	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:103155820C>T	uc003vca.2	-	50	8091	c.7931G>A	c.(7930-7932)AGA>AAA	p.R2644K	RELN_uc010liz.2_Missense_Mutation_p.R2644K	NM_005045	NP_005036	P78509	RELN_HUMAN	reelin isoform a	2644					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			ovary(8)|upper_aerodigestive_tract(5)|large_intestine(2)|central_nervous_system(2)|skin(1)|pancreas(1)	19				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCCGTCATGTCTTGGCTGCCA	0.532	NSCLC(146;835 1944 15585 22231 52158)		NA											14	62					0	0	0.016723	0	0
PIK3CG	5294	broad.mit.edu	37	7	106524641	106524641	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:106524641C>T	uc003vdv.3	+	9	2887	c.2802C>T	c.(2800-2802)GGC>GGT	p.G934G	PIK3CG_uc003vdu.2_Silent_p.G934G|PIK3CG_uc003vdw.2_Silent_p.G934G	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	934	PI3K/PI4K.				G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						CCTGTGCAGGCTACTGTGTGG	0.363			NA											102	174					0	0	0.01441	0	0
LAMB4	22798	broad.mit.edu	37	7	107743504	107743504	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:107743504G>A	uc010ljo.1	-	10	1249	c.1165C>T	c.(1165-1167)CCC>TCC	p.P389S	LAMB4_uc003vey.2_Missense_Mutation_p.P389S	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	389	Laminin EGF-like 2.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						CACGCGTAGGGATCTGAGATG	0.597			NA											35	45					0	0	0.019004	0	0
FLNC	2318	broad.mit.edu	37	7	128497383	128497383	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:128497383G>T	uc003vnz.3	+	46	7982	c.7773G>T	c.(7771-7773)AAG>AAT	p.K2591N	FLNC_uc003voa.3_Missense_Mutation_p.K2558N	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2591	Interaction with INPPL1.|Filamin 23.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TCAAGGCCAAGGTCACTGGTG	0.632			NA											4	67					0.00116845	0.00121655	0.001168	1	0
CREB3L2	64764	broad.mit.edu	37	7	137586170	137586170	+	Splice_Site	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:137586170T>A	uc003vtw.2	-	8	1370	c.975_splice	c.e8-1	p.K325_splice	CREB3L2_uc003vtx.1_Splice_Site_p.K325_splice|CREB3L2_uc003vtv.2_Splice_Site_p.K262_splice	NM_194071	NP_919047	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like						chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	soft_tissue(158)|upper_aerodigestive_tract(1)|ovary(1)	160						GACTCCACTCTACAAAGGAGG	0.463			NA	T	FUS	fibromyxoid sarcoma								7	81					0	0	0.004482	0	0
ZC3HAV1L	92092	broad.mit.edu	37	7	138713464	138713464	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:138713464C>G	uc003vum.1	-	3	756	c.744G>C	c.(742-744)AAG>AAC	p.K248N		NM_080660	NP_542391	Q96H79	ZCCHL_HUMAN	zinc finger CCCH-type, antiviral 1-like	248											0						TTTCAAGCATCTTGTGCAGCT	0.403			NA											24	158					0	0	0.01892	0	0
DENND2A	27147	broad.mit.edu	37	7	140301227	140301227	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:140301227C>G	uc010lnj.2	-	1	1116	c.971G>C	c.(970-972)AGA>ACA	p.R324T	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.R324T|DENND2A_uc003vvw.2_Missense_Mutation_p.R324T|DENND2A_uc003vvx.2_Missense_Mutation_p.R324T	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	324										ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GGATTTCTGTCTCCCGGTCCA	0.378			NA											17	163					0	0	0.006122	0	0
TRPV6	55503	broad.mit.edu	37	7	142570163	142570163	+	Silent	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:142570163G>A	uc003wbx.1	-	14	2073	c.1857C>T	c.(1855-1857)TGC>TGT	p.C619C	TRPV6_uc003wbw.1_Silent_p.C405C|TRPV6_uc010lou.1_Silent_p.C490C	NM_018646	NP_061116	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel,	619	Cytoplasmic (Potential).				regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			ovary(2)	2	Melanoma(164;0.059)					ACTCCCGTCCGCAGATCCCGG	0.622			NA											7	58					0	0	0.001984	0	0
KEL	3792	broad.mit.edu	37	7	142640627	142640627	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:142640627A>G	uc003wcb.2	-	15	1859	c.1649T>C	c.(1648-1650)GTA>GCA	p.V550A		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	550	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					TGGAAAGACTACCACATGGTC	0.547			NA											25	77					0	0	0.007291	0	0
OR2A14	135941	broad.mit.edu	37	7	143827010	143827010	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:143827010C>A	uc011kua.1	+	1	805	c.805C>A	c.(805-807)CAG>AAG	p.Q269K		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	269	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					TCCTGAGGAGCAGCAGAAAGT	0.552			NA											100	319					3.21569e-47	4.5181e-47	0.01441	1	0
AGAP3	116988	broad.mit.edu	37	7	150817157	150817157	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:150817157C>T	uc003wjg.1	+	8	1056	c.1053C>T	c.(1051-1053)CGC>CGT	p.R351R	AGAP3_uc003wje.1_Silent_p.R123R|AGAP3_uc003wjf.1_Silent_p.R351R|AGAP3_uc010lpy.1_Intron|AGAP3_uc003wjh.1_Silent_p.R531R|AGAP3_uc003wji.1_5'Flank	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	315	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						GGGAGCTGCGCATCGAGACCA	0.657			NA											9	87					0	0	0.006214	0	0
CHPF2	54480	broad.mit.edu	37	7	150932245	150932245	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr7:150932245C>A	uc003wjr.1	+	2	1888	c.375C>A	c.(373-375)GCC>GCA	p.A125A	CHPF2_uc003wjq.1_Silent_p.A117A	NM_019015	NP_061888	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	125	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(1)	1						GTACGGTGGCCCATCACTTCC	0.657			NA											44	138					1.7489e-18	2.21867e-18	0.011902	1	0
CSMD1	64478	broad.mit.edu	37	8	2855548	2855548	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:2855548G>T	uc011kwk.1	-	54	8755	c.8365C>A	c.(8365-8367)CTG>ATG	p.L2789M	CSMD1_uc011kwj.1_Missense_Mutation_p.L2118M|CSMD1_uc010lrg.2_Missense_Mutation_p.L799M	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2789	Extracellular (Potential).|Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACGTGGGCAGAGGGCTACTC	0.557			NA											12	43					5.50884e-06	5.94075e-06	0.013537	1	0
C8orf80	389643	broad.mit.edu	37	8	27891171	27891171	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:27891171A>G	uc003xgm.3	-	14	1798	c.1655T>C	c.(1654-1656)GTT>GCT	p.V552A		NM_001010906	NP_001010906	Q68CJ6	SLIP_HUMAN	speckled-like pattern in the germinal center	552						nucleus	GTP binding|GTPase activity			ovary(1)|central_nervous_system(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.126)|Kidney(114;0.15)|Colorectal(74;0.181)		TTTCAGGCAAACAGCTTTCAG	0.408			NA											11	116					0	0	0.008291	0	0
TEX15	56154	broad.mit.edu	37	8	30703478	30703478	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:30703478G>C	uc003xil.2	-	1	3056	c.3056C>G	c.(3055-3057)ACT>AGT	p.T1019S		NM_031271	NP_112561	Q9BXT5	TEX15_HUMAN	testis expressed 15	1019										ovary(3)|upper_aerodigestive_tract(2)|skin(2)	7				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		TCCTACTTTAGTTATAAGCTG	0.338			NA											60	282					0	0	0.01441	0	0
PLAT	5327	broad.mit.edu	37	8	42046532	42046532	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:42046532C>G	uc003xos.2	-	4	382	c.173G>C	c.(172-174)CGC>CCC	p.R58P	PLAT_uc010lxf.1_Intron|PLAT_uc010lxg.1_Missense_Mutation_p.R58P|PLAT_uc003xot.2_Intron|PLAT_uc011lcm.1_Missense_Mutation_p.R58P|PLAT_uc011lcn.1_Missense_Mutation_p.R58P	NM_000930	NP_000921	P00750	TPA_HUMAN	plasminogen activator, tissue isoform 1	58	Fibronectin type-I.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|skin(1)	2	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GAGCACAGGGCGCAGCCATGA	0.468			NA											93	510					0	0	0.01441	0	0
PXDNL	137902	broad.mit.edu	37	8	52359614	52359614	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:52359614C>T	uc003xqu.3	-	12	1576	c.1475G>A	c.(1474-1476)AGT>AAT	p.S492N		NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	492	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCCCAACGAACTGACTGCTTG	0.468			NA											55	215					0	0	0.01441	0	0
NPBWR1	2831	broad.mit.edu	37	8	53853265	53853265	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:53853265C>A	uc011ldu.1	+	1	798	c.798C>A	c.(796-798)CCC>CCA	p.P266P		NM_005285	NP_005276	P48145	NPBW1_HUMAN	G protein-coupled receptor 7	266	Helical; Name=6; (Potential).				synaptic transmission	plasma membrane	opioid receptor activity|protein binding			ovary(2)|breast(1)	3		Lung NSC(129;0.0222)|all_epithelial(80;0.0301)|all_lung(136;0.0431)				GCTGGACGCCCTACCACCTGA	0.657			NA											4	60					0.00909568	0.00937058	0.009096	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767721	77767721	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:77767721C>A	uc003yav.2	+	10	8816	c.8429C>A	c.(8428-8430)CCT>CAT	p.P2810H	ZFHX4_uc003yau.1_Missense_Mutation_p.P2855H|ZFHX4_uc003yaw.1_Missense_Mutation_p.P2810H	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2810						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCAACCACACCTACCACGGAG	0.473			NA								HNSCC(33;0.089)			26	54					3.08376e-08	3.46371e-08	0.01892	1	0
LRRCC1	85444	broad.mit.edu	37	8	86042277	86042277	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:86042277A>G	uc003ycw.2	+	11	1904	c.1750A>G	c.(1750-1752)AAA>GAA	p.K584E	LRRCC1_uc010lzz.1_RNA|LRRCC1_uc010maa.1_Missense_Mutation_p.K285E|LRRCC1_uc003ycx.2_Missense_Mutation_p.K491E|LRRCC1_uc003ycy.2_Missense_Mutation_p.K564E	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	584	Potential.				cell division|mitosis	centriole|nucleus					0						TCTTGCATTGAAAGAACAGGA	0.358			NA											16	102					0	0	0.006122	0	0
MATN2	4147	broad.mit.edu	37	8	99015950	99015950	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:99015950G>T	uc003yic.2	+	8	1497	c.1266G>T	c.(1264-1266)GAG>GAT	p.E422D	MATN2_uc003yib.1_Missense_Mutation_p.E422D|MATN2_uc010mbh.1_Missense_Mutation_p.E381D|MATN2_uc003yid.2_Missense_Mutation_p.E422D|MATN2_uc003yie.1_Missense_Mutation_p.E422D|MATN2_uc010mbi.1_Missense_Mutation_p.E255D	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	422	EGF-like 5.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			ACATGGAGGAGAGCTACTACT	0.577			NA											7	91					2.0095e-06	2.18812e-06	0.001984	1	0
KLF10	7071	broad.mit.edu	37	8	103664623	103664623	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:103664623C>G	uc011lhk.1	-	2	193	c.39G>C	c.(37-39)GAG>GAC	p.E13D	KLF10_uc011lhj.1_Missense_Mutation_p.E2D	NM_005655	NP_005646	Q13118	KLF10_HUMAN	Kruppel-like factor 10 isoform a	13					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			CCATTCTTTCCTCCTATAAAA	0.303	Esophageal Squamous(16;495 519 2144 16528 44005)		NA											7	171					0	0	0.001984	0	0
RIMS2	9699	broad.mit.edu	37	8	104927789	104927789	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:104927789A>C	uc003yls.2	+	5	1454	c.1213A>C	c.(1213-1215)AGT>CGT	p.S405R	RIMS2_uc003ylp.2_Missense_Mutation_p.S627R|RIMS2_uc003ylw.2_Missense_Mutation_p.S435R|RIMS2_uc003ylq.2_Missense_Mutation_p.S435R|RIMS2_uc003ylr.2_Missense_Mutation_p.S482R|RIMS2_uc003ylt.2_Missense_Mutation_p.S28R|RIMS2_uc003ylu.1_Missense_Mutation_p.S18R|RIMS2_uc003ylv.1_Missense_Mutation_p.S18R	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	705	PDZ.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAAAAAGGAAGTTTAGCTGA	0.323			NA								HNSCC(12;0.0054)			6	99					0	0	0.00308	0	0
TM7SF4	81501	broad.mit.edu	37	8	105361663	105361663	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:105361663C>T	uc003ylx.1	+	2	932	c.883C>T	c.(883-885)CTG>TTG	p.L295L		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	295	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAACCTGGGGCTGTTTTTCCT	0.488			NA											62	264					0	0	0.01441	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457293	110457293	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:110457293C>A	uc003yne.2	+	38	5299	c.5195C>A	c.(5194-5196)CCT>CAT	p.P1732H		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	1732	IPT/TIG 9.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATGGAGTGCCTGCCCAGTGC	0.433			NA								HNSCC(38;0.096)			150	210					1.13155e-68	1.61886e-68	0.01441	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110504206	110504206	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:110504206T>A	uc003yne.2	+	62	10323	c.10219T>A	c.(10219-10221)TGG>AGG	p.W3407R		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3407	Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTCAACTCTCTGGCATGCAGC	0.333			NA								HNSCC(38;0.096)			6	21					0	0	0.001168	0	0
CSMD3	114788	broad.mit.edu	37	8	113275890	113275890	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:113275890A>T	uc003ynu.2	-	61	9999	c.9840T>A	c.(9838-9840)AGT>AGA	p.S3280R	CSMD3_uc003yns.2_Missense_Mutation_p.S2482R|CSMD3_uc003ynt.2_Missense_Mutation_p.S3240R|CSMD3_uc011lhx.1_Missense_Mutation_p.S3111R	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3280	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GTACTTCACCACTCCAGGTAC	0.393			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			35	67					0	0	0.017118	0	0
CSMD3	114788	broad.mit.edu	37	8	113275989	113275989	+	Silent	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:113275989T>A	uc003ynu.2	-	61	9900	c.9741A>T	c.(9739-9741)ACA>ACT	p.T3247T	CSMD3_uc003yns.2_Silent_p.T2449T|CSMD3_uc003ynt.2_Silent_p.T3207T|CSMD3_uc011lhx.1_Silent_p.T3078T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3247	Sushi 25.|Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGTCGAAATTTGTTCCTTCCA	0.453			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	147					0	0	0.001168	0	0
CSMD3	114788	broad.mit.edu	37	8	113651001	113651001	+	Silent	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:113651001A>G	uc003ynu.2	-	21	3609	c.3450T>C	c.(3448-3450)TAT>TAC	p.Y1150Y	CSMD3_uc003yns.2_Silent_p.Y422Y|CSMD3_uc003ynt.2_Silent_p.Y1110Y|CSMD3_uc011lhx.1_Silent_p.Y1046Y	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1150	Extracellular (Potential).|CUB 6.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TGAAATTTCCATAGAGACCAG	0.383			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	90					0	0	0.008361	0	0
EIF3H	8667	broad.mit.edu	37	8	117658741	117658741	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:117658741C>A	uc003yoa.2	-	7	956	c.930G>T	c.(928-930)CCG>CCT	p.P310P	EIF3H_uc003yob.2_Silent_p.P324P	NM_003756	NP_003747	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3,	310					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(3)	3	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					TCCTGGCAGGCGGCTGTGGTG	0.552			NA											86	308					1.67174e-50	2.36579e-50	0.01441	1	0
HAS2	3037	broad.mit.edu	37	8	122641020	122641020	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:122641020C>T	uc003yph.2	-	2	1099	c.561G>A	c.(559-561)TGG>TGA	p.W187*		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	187	Cytoplasmic (Potential).					integral to plasma membrane	hyaluronan synthase activity	p.W187C(1)	HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			TTTTTCCACCCCATTTTTGCA	0.463			NA											75	326					0	0	0.01441	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134478232	134478232	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:134478232C>A	uc003yuk.2	-	6	1237	c.408G>T	c.(406-408)TCG>TCT	p.S136S	ST3GAL1_uc003yum.2_Silent_p.S136S	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	136	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			GGCAGCCCACCGACCTCTTCT	0.577			NA											34	114					1.08052e-11	1.27196e-11	0.019004	1	0
FAM135B	51059	broad.mit.edu	37	8	139144901	139144901	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:139144901C>A	uc003yuy.2	-	20	4327	c.4156G>T	c.(4156-4158)GTG>TTG	p.V1386L	FAM135B_uc003yux.2_Missense_Mutation_p.V1287L|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1386										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GAATCCAGCACAGCGATGTGA	0.522			NA								HNSCC(54;0.14)			173	229					4.18953e-109	6.03785e-109	0.01441	1	0
FAM135B	51059	broad.mit.edu	37	8	139164526	139164527	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:139164526_139164527CC>AA	uc003yuy.2	-	13	2362_2363	c.2191_2192GG>TT	c.(2191-2193)GGA>TTA	p.G731L	FAM135B_uc003yux.2_Missense_Mutation_p.G632L|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G293L|FAM135B_uc003yvb.2_Missense_Mutation_p.G293L	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	731										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTCTGTGTGTCCACCCTCTAGG	0.559			NA								HNSCC(54;0.14)			31	57					0	0	0.004672	0	0
FAM135B	51059	broad.mit.edu	37	8	139268979	139268979	+	Silent	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:139268979T>A	uc003yuy.2	-	5	492	c.321A>T	c.(319-321)GTA>GTT	p.V107V	FAM135B_uc003yux.2_Silent_p.V8V|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	107										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTTGAAAATCTACTTCACTCA	0.438			NA								HNSCC(54;0.14)			4	64					0	0	0.009096	0	0
CPSF1	29894	broad.mit.edu	37	8	145623236	145623236	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:145623236A>G	uc003zcj.2	-	20	2081	c.2006T>C	c.(2005-2007)CTG>CCG	p.L669P		NM_013291	NP_037423	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1,	669					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			skin(1)	1	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			ACTCTTCAGCAGGAACATGGT	0.677	NSCLC(133;1088 1848 27708 34777 35269)		NA											18	95					0	0	0.01892	0	0
PTPRD	5789	broad.mit.edu	37	9	8486043	8486043	+	Missense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:8486043A>T	uc003zkk.2	-	27	3485	c.2774T>A	c.(2773-2775)CTT>CAT	p.L925H	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Missense_Mutation_p.L916H|PTPRD_uc003zkm.2_Missense_Mutation_p.L912H|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	925	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTCTGAGTGAAGGTTTTGAGG	0.478			NA								TSP Lung(15;0.13)			23	68					0	0	0.016522	0	0
PTPLAD2	401494	broad.mit.edu	37	9	21011691	21011691	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:21011691G>T	uc010miq.1	-	5	433	c.387C>A	c.(385-387)TAC>TAA	p.Y129*	PTPLAD2_uc003zoj.1_Nonsense_Mutation_p.Y92*|PTPLAD2_uc010mir.1_Nonsense_Mutation_p.Y129*	NM_001010915	NP_001010915	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain	129	Helical; (Potential).				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			skin(1)	1				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		TGCTATAAGTGTACCTGAAAG	0.368			NA											10	30					0.00829132	0.00855315	0.008291	1	0
LINGO2	158038	broad.mit.edu	37	9	27949535	27949535	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:27949535G>T	uc003zqu.1	-	2	1329	c.1135C>A	c.(1135-1137)CAA>AAA	p.Q379K	LINGO2_uc010mjf.1_Missense_Mutation_p.Q379K|LINGO2_uc003zqv.1_Missense_Mutation_p.Q379K	NM_152570	NP_689783	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	379	LRRCT.|Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CACATAGGTTGCTGGCCACCA	0.517			NA											30	27					5.77227e-19	7.35847e-19	0.008361	1	0
TAF1L	138474	broad.mit.edu	37	9	32630480	32630480	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:32630480G>T	uc003zrg.1	-	1	5188	c.5098C>A	c.(5098-5100)CCA>ACA	p.P1700T	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1700					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGTTTTTCTGGAGTGGCAGTG	0.463			NA											86	202					1.42954e-44	1.99779e-44	0.01441	1	0
KIF24	347240	broad.mit.edu	37	9	34257209	34257209	+	Missense_Mutation	SNP	T	T	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:34257209T>G	uc003zua.3	-	11	2516	c.2396A>C	c.(2395-2397)CAG>CCG	p.Q799P	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	799					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			ATTCGTGAGCTGACCCTCTGG	0.478			NA											69	157					0	0	0.01441	0	0
PIGO	84720	broad.mit.edu	37	9	35092310	35092310	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:35092310A>C	uc003zwd.2	-	7	1970	c.1574T>G	c.(1573-1575)TTT>TGT	p.F525C	PIGO_uc003zwc.1_3'UTR|PIGO_uc003zwe.2_Intron|PIGO_uc003zwf.2_Intron|PIGO_uc003zwg.1_Missense_Mutation_p.F88C	NM_032634	NP_116023	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	525	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			large_intestine(1)|ovary(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TTTCCACAGAAAAGGGAGGAA	0.582			NA											69	45					0	0	0.01441	0	0
FRMPD1	22844	broad.mit.edu	37	9	37724227	37724227	+	Silent	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:37724227T>C	uc004aag.1	+	7	566	c.522T>C	c.(520-522)AAT>AAC	p.N174N	FRMPD1_uc004aah.1_Silent_p.N174N|FRMPD1_uc011lqm.1_5'UTR|FRMPD1_uc011lqn.1_Silent_p.N43N	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	174						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		TCCAGGGTAATTCTCTGCTGT	0.299			NA											83	38					0	0	0.01441	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396791	38396791	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:38396791G>T	uc004aay.2	+	2	1158	c.1046G>T	c.(1045-1047)GGG>GTG	p.G349V		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	349					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	AGGAAAGTGGGGAACCCCTTT	0.572			NA											59	34					1.93748e-29	2.59655e-29	0.01441	1	0
ZNF658	26149	broad.mit.edu	37	9	40772612	40772612	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:40772612C>A	uc004abs.2	-	5	2815	c.2663G>T	c.(2662-2664)GGG>GTG	p.G888V	ZNF658_uc010mmm.1_Intron|ZNF658_uc010mmn.1_Missense_Mutation_p.G888V	NM_033160	NP_149350	Q5TYW1	ZN658_HUMAN	zinc finger protein 658	888	C2H2-type 19; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		GAAAGTCTTCCCACAGTCATT	0.453			NA											73	105					1.3009e-50	1.84432e-50	0.01441	1	0
FAM75A6	389730	broad.mit.edu	37	9	43624943	43624943	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:43624943G>T	uc011lrb.1	-	4	3773	c.3744C>A	c.(3742-3744)CAC>CAA	p.H1248Q		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1248						integral to membrane					0						AGTAGAAGAGGTGCCTGTGGT	0.502			NA											8	271					0.000157383	0.000165845	0.00308	1	0
FLJ46321	389763	broad.mit.edu	37	9	84607513	84607513	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:84607513C>T	uc004amn.2	+	4	2175	c.2128C>T	c.(2128-2130)CTG>TTG	p.L710L		NM_001001670	NP_001001670	Q6ZQQ2	F75D1_HUMAN	hypothetical protein LOC389763	710						integral to membrane					0						CCATGAGTCTCTGTCATTGCT	0.483			NA											37	47					0	0	0.017118	0	0
HNRNPK	3190	broad.mit.edu	37	9	86592668	86592668	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:86592668T>C	uc004ang.3	-	4	316	c.92A>G	c.(91-93)CAA>CGA	p.Q31R	HNRNPK_uc011lsw.1_5'Flank|HNRNPK_uc004and.3_5'Flank|HNRNPK_uc004ank.3_Missense_Mutation_p.Q31R|HNRNPK_uc004anf.3_Missense_Mutation_p.Q31R|HNRNPK_uc004anh.3_Missense_Mutation_p.Q31R|HNRNPK_uc011lsx.1_Missense_Mutation_p.Q31R|HNRNPK_uc004ani.3_Missense_Mutation_p.Q31R|HNRNPK_uc004anj.3_Missense_Mutation_p.Q31R|HNRNPK_uc004ann.3_Missense_Mutation_p.Q31R|HNRNPK_uc004anl.3_Missense_Mutation_p.Q31R|HNRNPK_uc004anm.3_Missense_Mutation_p.Q31R|RMI1_uc004anq.3_5'Flank|RMI1_uc004anr.3_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	31	Necessary for interaction with DDX1.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						TTTAAATGCTTGTTCCTCTTC	0.358			NA											17	63					0	0	0.006122	0	0
RMI1	80010	broad.mit.edu	37	9	86617462	86617462	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:86617462C>G	uc004anq.3	+	3	1969	c.1561C>G	c.(1561-1563)CTC>GTC	p.L521V	RMI1_uc004anr.3_Missense_Mutation_p.L521V|RMI1_uc004anp.3_Missense_Mutation_p.L521V|RMI1_uc004ans.3_Missense_Mutation_p.L521V	NM_024945	NP_079221	Q9H9A7	RMI1_HUMAN	RMI1, RecQ mediated genome instability 1,	521					DNA replication	nucleus					0						AACTGGAAATCTCTCAAGTTC	0.378			NA											5	242					0	0	0.001168	0	0
SPTLC1	10558	broad.mit.edu	37	9	94794786	94794786	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:94794786C>G	uc004arl.1	-	15	1421	c.1383G>C	c.(1381-1383)GCG>GCC	p.A461A	SPTLC1_uc011ltv.1_Missense_Mutation_p.V451L	NM_006415	NP_006406	O15269	SPTC1_HUMAN	serine palmitoyltransferase subunit 1 isoform a	461	Cytoplasmic (Potential).					integral to membrane|SPOTS complex	protein binding|pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			ovary(1)|breast(1)	2					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	TGATGGTGGACGCAGCTCTCT	0.527			NA											11	111					0	0	0.008291	0	0
COL15A1	1306	broad.mit.edu	37	9	101818644	101818644	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:101818644G>T	uc004azb.1	+	35	3501	c.3295G>T	c.(3295-3297)GGG>TGG	p.G1099W		NM_001855	NP_001846	P39059	COFA1_HUMAN	alpha 1 type XV collagen precursor	1099	Triple-helical region 8 (COL8).				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			ovary(6)	6		Acute lymphoblastic leukemia(62;0.0562)				TGGGCCACCGGGGCCCCCGGG	0.622			NA											58	48					5.82218e-30	7.81608e-30	0.01441	1	0
GRIN3A	116443	broad.mit.edu	37	9	104375693	104375693	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:104375693C>A	uc004bbp.1	-	6	3332	c.2731G>T	c.(2731-2733)GTT>TTT	p.V911F	GRIN3A_uc004bbq.1_Missense_Mutation_p.V911F	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	911	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	CCACAGGGAACCACCCTGTAC	0.458			NA											27	27					2.48779e-11	2.91544e-11	0.005443	1	0
EPB41L4B	54566	broad.mit.edu	37	9	111947854	111947854	+	Missense_Mutation	SNP	T	T	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:111947854T>C	uc004bdz.1	-	23	2628	c.2333A>G	c.(2332-2334)CAC>CGC	p.H778R		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	778						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						ACAGCGAGAGTGGGCACAGTG	0.408			NA											33	20					0	0	0.015359	0	0
CEP110	11064	broad.mit.edu	37	9	123920102	123920102	+	Silent	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:123920102A>C	uc004bkx.1	+	27	4612	c.4581A>C	c.(4579-4581)GCA>GCC	p.A1527A	CEP110_uc004bla.1_Silent_p.A975A|CEP110_uc010mvo.1_Silent_p.A196A|CEP110_uc004blb.1_Silent_p.A196A|CEP110_uc010mvp.1_5'UTR	NM_007018	NP_008949	Q7Z7A1	CNTRL_HUMAN	centrosomal protein 110kDa	1527	Potential.				cell division|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein binding				0						AAATTGTAGCAGCAAAAGACT	0.408			NA											42	69					0	0	0.011902	0	0
RABGAP1	23637	broad.mit.edu	37	9	125782613	125782613	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:125782613A>T	uc011lzh.1	+	13	1803	c.1669A>T	c.(1669-1671)AAG>TAG	p.K557*	RABGAP1_uc004bnl.3_RNA	NM_012197	NP_036329	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	557					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			ovary(3)|kidney(2)	5						TGTGAGACCGAAGCAGTTGTC	0.383			NA											48	55					0	0	0.01441	0	0
SURF4	6836	broad.mit.edu	37	9	136230446	136230446	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:136230446C>A	uc004cdj.2	-	6	863	c.733G>T	c.(733-735)GTG>TTG	p.V245L	SURF4_uc011mda.1_Missense_Mutation_p.V236L|SURF4_uc010nal.2_3'UTR|SURF4_uc011mdb.1_Missense_Mutation_p.V202L|SURF4_uc011mdc.1_Missense_Mutation_p.V202L|SURF4_uc011mdd.1_3'UTR	NM_033161	NP_149351	O15260	SURF4_HUMAN	surfeit 4	245	Helical; (Potential).					endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	protein binding				0				OV - Ovarian serous cystadenocarcinoma(145;5.32e-07)|Epithelial(140;4.56e-06)|all cancers(34;4.25e-05)		CCCCCAATCACCGACATGGTC	0.532			NA											14	54					2.31682e-05	2.47128e-05	0.003163	1	0
GLRA2	2742	broad.mit.edu	37	X	14627186	14627186	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:14627186C>T	uc010nep.2	+	8	1121	c.789C>T	c.(787-789)ATC>ATT	p.I263I	GLRA2_uc010neq.2_Silent_p.I263I|GLRA2_uc004cwe.3_Silent_p.I263I|GLRA2_uc011mio.1_Silent_p.I174I|GLRA2_uc011mip.1_Silent_p.I241I	NM_001118885	NP_001112357	P23416	GLRA2_HUMAN	glycine receptor, alpha 2 isoform A	263	Helical; (Probable).				neuropeptide signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			ovary(1)|lung(1)	2	Hepatocellular(33;0.128)				Ethanol(DB00898)|Glycine(DB00145)	AGATGTACATCCCAAGCCTGC	0.433			NA											21	95					0	0	0.010504	0	0
SYAP1	94056	broad.mit.edu	37	X	16773137	16773137	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:16773137C>T	uc004cxp.2	+	6	738	c.645C>T	c.(643-645)CTC>CTT	p.L215L	SYAP1_uc004cxo.2_Silent_p.L215L|SYAP1_uc011miv.1_Silent_p.L181L	NM_032796	NP_116185	Q96A49	SYAP1_HUMAN	SYAP1 protein	215										skin(1)	1	Hepatocellular(33;0.0997)					CAGCCCAGCTCACGGCCCTGG	0.512			NA											45	41					0	0	0.01441	0	0
SAT1	6303	broad.mit.edu	37	X	23801932	23801932	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:23801932G>A	uc004dau.2	+	3	328	c.134G>A	c.(133-135)GGT>GAT	p.G45D	SAT1_uc010nfv.2_Missense_Mutation_p.G45D|SAT1_uc004dav.2_RNA	NM_002970	NP_002961	P21673	SAT1_HUMAN	diamine N-acetyltransferase 1	45	N-acetyltransferase.				angiogenesis|polyamine biosynthetic process	cytosol	diamine N-acetyltransferase activity|protein binding				0					Spermine(DB00127)	CTAGAAGATGGTTTTGGAGAG	0.587			NA											34	27					0	0	0.012213	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254960	30254961	+	Missense_Mutation	DNP	TA	TA	GT			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:30254960_30254961TA>GT	uc004dca.1	+	5	1656_1657	c.919_920TA>GT	c.(919-921)TAT>GTT	p.Y307V		NM_002365	NP_002356	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	307	MAGE.										0						CCAGTTCTGGTATGAAGAGGCT	0.515			NA											18	23					0	0	0.004672	0	0
FAM47C	442444	broad.mit.edu	37	X	37028810	37028810	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:37028810C>A	uc004ddl.1	+	1	2341	c.2327C>A	c.(2326-2328)CCA>CAA	p.P776Q		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	776										ovary(3)	3						CATCTCCACCCAGAGCTTCCC	0.632			NA											12	21					3.27435e-08	3.67252e-08	0.020292	1	0
USP9X	8239	broad.mit.edu	37	X	41000347	41000347	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:41000347A>G	uc004dfb.2	+	8	1532	c.899A>G	c.(898-900)AAT>AGT	p.N300S	USP9X_uc004dfc.2_Missense_Mutation_p.N300S	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	300					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GAAGCAAAGAATGAAGCCAAA	0.299	Ovarian(172;1807 2695 35459 49286)		NA											91	9					0	0	0.01441	0	0
GPR34	2857	broad.mit.edu	37	X	41554925	41554925	+	Silent	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:41554925C>G	uc004dfp.3	+	3	323	c.39C>G	c.(37-39)GTC>GTG	p.V13V	CASK_uc004dfl.3_Intron|CASK_uc004dfm.3_Intron|CASK_uc004dfn.3_Intron|GPR34_uc004dfq.3_Silent_p.V13V|GPR34_uc010nhg.2_Silent_p.V13V|GPR34_uc004dfr.3_Silent_p.V13V	NM_001097579	NP_001091048	Q9UPC5	GPR34_HUMAN	G protein-coupled receptor 34	13	Extracellular (Potential).					integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1						CAACTTCAGTCAGCAGCTGGC	0.423			NA											8	419					0	0	0.008291	0	0
NDP	4693	broad.mit.edu	37	X	43817789	43817789	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:43817789C>T	uc004dga.3	-	2	682	c.103G>A	c.(103-105)GAC>AAC	p.D35N		NM_000266	NP_000257	Q00604	NDP_HUMAN	norrin precursor	35					canonical Wnt receptor signaling pathway|cell proliferation|cell-cell signaling|nervous system development|positive regulation of transcription, DNA-dependent|sensory perception of sound|vacuole organization|visual perception	extracellular matrix|extracellular space	cell surface binding|frizzled binding|growth factor activity|protein homodimerization activity				0						CGTCGAGGGTCCGAGTCCATT	0.473			NA											11	591					0	0	0.008291	0	0
GPKOW	27238	broad.mit.edu	37	X	48973405	48973405	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:48973405C>T	uc004dmr.2	-	6	899	c.892G>A	c.(892-894)GAC>AAC	p.D298N		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	298						nucleus	nucleic acid binding			ovary(2)	2						GTGTTCTTGTCAAACTCCTGC	0.567			NA											110	583					0	0	0.01441	0	0
GPKOW	27238	broad.mit.edu	37	X	48973451	48973451	+	Silent	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:48973451C>T	uc004dmr.2	-	6	853	c.846G>A	c.(844-846)GTG>GTA	p.V282V		NM_015698	NP_056513	Q92917	GPKOW_HUMAN	G patch domain and KOW motifs	282						nucleus	nucleic acid binding			ovary(2)	2						CACTAACAGTCACCACCCGGC	0.547			NA											172	706					0	0	0.01441	0	0
SYP	6855	broad.mit.edu	37	X	49050789	49050789	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:49050789G>C	uc004dmz.1	-	4	273	c.257C>G	c.(256-258)ACC>AGC	p.T86S	SYP_uc011mmz.1_5'UTR|SYP_uc004dna.1_Missense_Mutation_p.T80S	NM_003179	NP_003170	P08247	SYPH_HUMAN	synaptophysin	86	Vesicular (Potential).|MARVEL.				regulation of long-term neuronal synaptic plasticity|regulation of short-term neuronal synaptic plasticity|synaptic vesicle maturation|synaptic vesicle membrane organization	cell junction|integral to synaptic vesicle membrane|synaptosome	calcium ion binding|cholesterol binding|transporter activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(315;0.00016)				CCCTCGGCAGGTGGGTGCATC	0.582			NA											12	620					0	0	0.016723	0	0
HUWE1	10075	broad.mit.edu	37	X	53641577	53641577	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:53641577T>A	uc004dsp.2	-	23	2581	c.2179A>T	c.(2179-2181)AGT>TGT	p.S727C		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	727					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						TCATCCTCACTAGAGGCTTCT	0.488			NA											37	37					0	0	0.00623	0	0
KIAA2022	340533	broad.mit.edu	37	X	73964291	73964291	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:73964291G>C	uc004eby.2	-	3	718	c.101C>G	c.(100-102)GCA>GGA	p.A34G		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	34					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						TGACTTCATTGCCACATCCTG	0.453			NA											6	12					0	0	0.001168	0	0
LPAR4	2846	broad.mit.edu	37	X	78010954	78010954	+	Silent	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:78010954C>A	uc010nme.2	+	2	993	c.588C>A	c.(586-588)GTC>GTA	p.V196V		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	196	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						CCAAACGTGTCTGGAAGACTT	0.413			NA											9	27					0.000442599	0.000462664	0.006214	1	0
P2RY10	27334	broad.mit.edu	37	X	78216847	78216847	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:78216847G>C	uc004ede.2	+	4	1199	c.830G>C	c.(829-831)TGT>TCT	p.C277S	P2RY10_uc004edf.2_Missense_Mutation_p.C277S	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	277	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						ATTAGCAGTTGTCCCGTTGTC	0.413			NA											72	62					0	0	0.01441	0	0
POU3F4	5456	broad.mit.edu	37	X	82763575	82763575	+	Silent	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:82763575G>T	uc004eeg.2	+	1	307	c.243G>T	c.(241-243)GTG>GTT	p.V81V		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	81					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						AGCAGGACGTGAAGCCCGGGC	0.667			NA											7	3					0.00198382	0.00205458	0.001984	1	0
DACH2	117154	broad.mit.edu	37	X	85403695	85403695	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:85403695G>T	uc004eew.2	+	1	241	c.71G>T	c.(70-72)CGG>CTG	p.R24L	DACH2_uc004eex.2_Missense_Mutation_p.R24L|DACH2_uc010nmq.2_5'UTR	NM_053281	NP_444511	Q96NX9	DACH2_HUMAN	dachshund 2 isoform a	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			ovary(4)|pancreas(1)	5						GGCTTATTCCGGGCCGAACCC	0.582			NA											8	7					0.000157383	0.000165845	0.00308	1	0
BHLHB9	80823	broad.mit.edu	37	X	102005310	102005310	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:102005310C>G	uc010nog.2	+	4	1958	c.1387C>G	c.(1387-1389)CTT>GTT	p.L463V	BHLHB9_uc011mrq.1_Missense_Mutation_p.L463V|BHLHB9_uc011mrr.1_Missense_Mutation_p.L463V|BHLHB9_uc011mrs.1_Missense_Mutation_p.L463V|BHLHB9_uc011mrt.1_Missense_Mutation_p.L463V|BHLHB9_uc004ejo.2_Missense_Mutation_p.L463V|BHLHB9_uc011mru.1_Missense_Mutation_p.L463V|BHLHB9_uc011mrv.1_Missense_Mutation_p.L463V	NM_001142526	NP_001135998	Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class	463						cytoplasm|nucleus	binding			ovary(2)	2						AACCAGAAATCTTGTTTTGAA	0.363			NA											3	128					0	0	0.004672	0	0
DOCK11	139818	broad.mit.edu	37	X	117788700	117788700	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:117788700T>A	uc004eqp.2	+	43	4894	c.4831T>A	c.(4831-4833)TAT>AAT	p.Y1611N	DOCK11_uc004eqq.2_Missense_Mutation_p.Y1390N	NM_144658	NP_653259	Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1611	DHR-2.				blood coagulation	cytosol	GTP binding			ovary(3)	3						AGCCAAGTCCTATGCAAGCAC	0.433			NA											219	38					0	0	0.01441	0	0
ATP1B4	23439	broad.mit.edu	37	X	119504691	119504691	+	Missense_Mutation	SNP	G	G	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:119504691G>T	uc004esr.2	+	3	534	c.450G>T	c.(448-450)AAG>AAT	p.K150N	ATP1B4_uc004esq.2_Missense_Mutation_p.K146N|ATP1B4_uc011mtx.1_Missense_Mutation_p.K115N|ATP1B4_uc011mty.1_Intron	NM_001142447	NP_001135919	Q9UN42	AT1B4_HUMAN	ATPase, (Na+)/K+ transporting, beta 4	150	Perinuclear space (Potential).				ATP biosynthetic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to plasma membrane|nuclear inner membrane	sodium:potassium-exchanging ATPase activity			ovary(1)|skin(1)	2						AGCGGGTAAAGCCTCCTGGTG	0.493			NA											394	121					1.38562e-190	2.0006e-190	0.01441	1	0
THOC2	57187	broad.mit.edu	37	X	122769970	122769970	+	Missense_Mutation	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:122769970G>C	uc004etu.2	-	19	2010	c.1978C>G	c.(1978-1980)CTT>GTT	p.L660V	THOC2_uc011muh.1_Missense_Mutation_p.L585V	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	660					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TACTGAAGAAGACCAGCAAGA	0.333			NA											7	109					0	0	0.001984	0	0
ODZ1	10178	broad.mit.edu	37	X	123631060	123631060	+	Silent	SNP	G	G	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:123631060G>C	uc004euj.2	-	20	3565	c.3501C>G	c.(3499-3501)GTC>GTG	p.V1167V	ODZ1_uc011muj.1_Silent_p.V1166V|ODZ1_uc010nqy.2_Silent_p.V1167V	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1167	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGGTTGATATGACTGGGGGCT	0.423			NA											39	14					0	0	0.005524	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686243	125686243	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:125686243A>G	uc004eul.2	-	1	600	c.349T>C	c.(349-351)TGT>CGT	p.C117R		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	117										skin(3)|ovary(1)	4						AGCGTGTTACACTTGGTGCCG	0.642			NA											31	82					0	0	0.007291	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218650	130218650	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:130218650C>T	uc004evz.2	+	6	1144	c.799C>T	c.(799-801)CGT>TGT	p.R267C	ARHGAP36_uc004ewa.2_Missense_Mutation_p.R255C|ARHGAP36_uc004ewb.2_Missense_Mutation_p.R236C|ARHGAP36_uc004ewc.2_Missense_Mutation_p.R131C	NM_144967	NP_659404	Q6ZRI8	RHG36_HUMAN	hypothetical protein LOC158763 precursor	267	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)	3						GCAGCGAGTGCGTCAGGTAAA	0.498			NA											22	219					0	0	0.010504	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135829672	135829672	+	Missense_Mutation	SNP	G	G	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:135829672G>A	uc004fab.2	-	3	791	c.329C>T	c.(328-330)ACA>ATA	p.T110I	ARHGEF6_uc011mwd.1_5'UTR|ARHGEF6_uc011mwe.1_5'UTR	NM_004840	NP_004831	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor 6	110	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity				0	Acute lymphoblastic leukemia(192;0.000127)					CTTACCTTCTGTTGCTTTGTT	0.403			NA											18	84					0	0	0.008871	0	0
SPANXN2	494119	broad.mit.edu	37	X	142795241	142795241	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:142795241C>T	uc004fbz.2	-	2	1191	c.437G>A	c.(436-438)GGA>GAA	p.G146E		NM_001009615	NP_001009615	Q5MJ10	SPXN2_HUMAN	SPANX-N2 protein	146										ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)					CTGTGAAGATCCTTCAGATGA	0.527			NA											82	612					0	0	0.01441	0	0
SLITRK2	84631	broad.mit.edu	37	X	144906014	144906014	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:144906014C>A	uc004fcd.2	+	5	3061	c.2071C>A	c.(2071-2073)CCT>ACT	p.P691T	SLITRK2_uc010nsp.2_Missense_Mutation_p.P691T|SLITRK2_uc010nso.2_Missense_Mutation_p.P691T|SLITRK2_uc011mwq.1_Missense_Mutation_p.P691T|SLITRK2_uc011mwr.1_Missense_Mutation_p.P691T|SLITRK2_uc011mws.1_Missense_Mutation_p.P691T|SLITRK2_uc004fcg.2_Missense_Mutation_p.P691T|SLITRK2_uc011mwt.1_Missense_Mutation_p.P691T|CXorf1_uc004fch.2_5'Flank	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	691	Cytoplasmic (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					TATCCCCCCACCTGTGGGTCA	0.468			NA											104	40					8.27256e-43	1.14588e-42	0.01441	1	0
CNGA2	1260	broad.mit.edu	37	X	150912021	150912021	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:150912021A>G	uc004fey.1	+	7	1270	c.1046A>G	c.(1045-1047)GAG>GGG	p.E349G		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	349	Cytoplasmic (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGATGAGGAGTACCTATTT	0.502			NA											26	229					0	0	0.01892	0	0
GABRA3	2556	broad.mit.edu	37	X	151533027	151533027	+	Missense_Mutation	SNP	T	T	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:151533027T>A	uc010ntk.1	-	2	256	c.16A>T	c.(16-18)ACA>TCA	p.T6S		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	6					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGTGACTTGTTTGTGTGATT	0.373	NSCLC(142;2578 2613 10251 16743)		NA											34	107					0	0	0.019004	0	0
PNCK	139728	broad.mit.edu	37	X	152938064	152938064	+	Missense_Mutation	SNP	C	C	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:152938064C>A	uc011myu.1	-	3	592	c.406G>T	c.(406-408)GGC>TGC	p.G136C	PNCK_uc011myt.1_Missense_Mutation_p.G70C|PNCK_uc004fia.2_Missense_Mutation_p.G65C|PNCK_uc004fhz.3_5'UTR|PNCK_uc010nuh.2_Missense_Mutation_p.G136C|PNCK_uc011myv.1_Missense_Mutation_p.G80C|PNCK_uc011myw.1_Missense_Mutation_p.G80C	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	pregnancy upregulated non-ubiquitously expressed	53	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCTCCTTGCCCCGGAGGGCC	0.657			NA											27	96					2.12542e-12	2.53241e-12	0.00632	1	0
L1CAM	3897	broad.mit.edu	37	X	153134081	153134081	+	Missense_Mutation	SNP	C	C	T			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:153134081C>T	uc004fjb.2	-	12	1589	c.1481G>A	c.(1480-1482)CGC>CAC	p.R494H	L1CAM_uc004fjc.2_Missense_Mutation_p.R494H|L1CAM_uc010nuo.2_Missense_Mutation_p.R489H|L1CAM_uc004fjd.1_Missense_Mutation_p.R308H	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	494	Extracellular (Potential).|Ig-like C2-type 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCAGAAGTAGCGTCCGGTGTC	0.552			NA											71	22					0	0	0.01441	0	0
L1CAM	3897	broad.mit.edu	37	X	153135921	153135921	+	Missense_Mutation	SNP	A	A	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:153135921A>C	uc004fjb.2	-	7	836	c.728T>G	c.(727-729)CTC>CGC	p.L243R	L1CAM_uc004fjc.2_Missense_Mutation_p.L243R|L1CAM_uc010nuo.2_Missense_Mutation_p.L238R|L1CAM_uc004fjd.1_Missense_Mutation_p.L57R|L1CAM_uc004fje.1_Missense_Mutation_p.L238R	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	243	Extracellular (Potential).|Ig-like C2-type 3.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGGGAAGAGCAGGCGCGG	0.607			NA											5	43					0	0	0.001168	0	0
TKTL1	8277	broad.mit.edu	37	X	153553731	153553731	+	Missense_Mutation	SNP	A	A	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:153553731A>G	uc004fkg.2	+	10	1550	c.1364A>G	c.(1363-1365)TAC>TGC	p.Y455C	TKTL1_uc011mzl.1_Missense_Mutation_p.Y449C|TKTL1_uc011mzm.1_Missense_Mutation_p.Y251C|TKTL1_uc004fkh.2_Missense_Mutation_p.Y399C	NM_012253	NP_036385	P51854	TKTL1_HUMAN	transketolase-like 1 isoform a	455					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			ovary(3)|skin(1)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATGGTTATTTACACCCCACAA	0.448			NA											3	147					0	0	0.009096	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4925273	4925273	+	Missense_Mutation	SNP	C	C	G			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrY:4925273C>G	uc004fqo.2	+	1	1143	c.409C>G	c.(409-411)CAT>GAT	p.H137D	PCDH11Y_uc010nwg.1_Missense_Mutation_p.H126D|PCDH11Y_uc004fql.1_Missense_Mutation_p.H126D|PCDH11Y_uc004fqm.1_Missense_Mutation_p.H126D|PCDH11Y_uc004fqn.1_Missense_Mutation_p.H137D	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked isoform c	137	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						AAGGGATGAGCATTGCTTTTA	0.408			NA											93	55					0	0	0.01441	0	0
FAM71A	149647	broad.mit.edu	37	1	212799845	212799845	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr1:212799845delG	uc001hjk.2	+	1	2030	c.1626delG	c.(1624-1626)GTGfs	p.V542fs	uc010pth.1_RNA	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	542										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		CAAAAGTAGTGGGCACACCAC	0.582			NA											77	125	---	---	---	---	NA	NA	NA	NA	NA
CNTN5	53942	broad.mit.edu	37	11	99690425	99690425	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr11:99690425delG	uc001pga.2	+	4	545	c.206delG	c.(205-207)TGGfs	p.W69fs	CNTN5_uc009ywv.1_Frame_Shift_Del_p.W69fs|CNTN5_uc001pfz.2_Frame_Shift_Del_p.W69fs|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	69					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCACCCAGCTGGCTAGGGGCA	0.383			NA											8	94	---	---	---	---	NA	NA	NA	NA	NA
KCNA6	3742	broad.mit.edu	37	12	4920328	4920328	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr12:4920328delG	uc001qng.2	+	1	1987	c.1121delG	c.(1120-1122)AGGfs	p.R374fs		NM_002235	NP_002226	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related	374						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(2)|ovary(1)	3						GCCTCCATGAGGGAGCTGGGG	0.597			NA								HNSCC(72;0.22)			16	48	---	---	---	---	NA	NA	NA	NA	NA
CD2BP2	10421	broad.mit.edu	37	16	30365550	30365552	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	CAT	CAT	-	-	CAT	CAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr16:30365550_30365552delCAT	uc002dxr.2	-	2	423_425	c.170_172delATG	c.(169-174)GATGGG>GGG	p.D57del	CD2BP2_uc002dxs.2_In_Frame_Del_p.D57del	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	57					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CTGGACCCCCCATCATCATCATC	0.532			NA											8	818	---	---	---	---	NA	NA	NA	NA	NA
IL12RB1	3594	broad.mit.edu	37	19	18194265	18194265	+	Frame_Shift_Del	DEL	G	G	-	rs113524129	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr19:18194265delG	uc002nhw.1	-	2	165	c.101delC	c.(100-102)CCGfs	p.P34fs	IL12RB1_uc010xqb.1_Frame_Shift_Del_p.P34fs|IL12RB1_uc002nhx.1_Frame_Shift_Del_p.P74fs|IL12RB1_uc002nhy.2_Frame_Shift_Del_p.P34fs	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	34	Extracellular (Potential).				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						CGGATATGGCGGGTCCTGAAA	0.562			NA											53	119	---	---	---	---	NA	NA	NA	NA	NA
REG1B	5968	broad.mit.edu	37	2	79314038	79314040	+	In_Frame_Del	DEL	TCT	TCT	-	rs139007123	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	TCT	TCT	-	-	TCT	TCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr2:79314038_79314040delTCT	uc002sny.2	-	3	193_195	c.81_83delAGA	c.(79-84)ACAGAG>ACG	p.E28del	REG1B_uc010ffv.1_In_Frame_Del_p.E28del|REG1B_uc010ffw.2_In_Frame_Del_p.E28del	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	28					cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						ATTAGGCAGCTCTGTCTGGGACT	0.493			NA											59	248	---	---	---	---	NA	NA	NA	NA	NA
RTDR1	27156	broad.mit.edu	37	22	23482595	23482595	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:23482595delG	uc002zwt.2	-	2	171	c.13delC	c.(13-15)CAGfs	p.Q5fs	RTDR1_uc010gtv.1_Frame_Shift_Del_p.Q5fs	NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	5							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		AAGGAGTTCTGGGAATGGGCC	0.488			NA											7	77	---	---	---	---	NA	NA	NA	NA	NA
SLC5A1	6523	broad.mit.edu	37	22	32439304	32439304	+	Frame_Shift_Del	DEL	G	G	-	rs148720069	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr22:32439304delG	uc003amc.2	+	1	268	c.36delG	c.(34-36)GCGfs	p.A12fs		NM_000343	NP_000334	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose	12	Extracellular (Potential).				carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			skin(1)	1						AGACCACCGCGGTCACCCGGC	0.597			NA											20	50	---	---	---	---	NA	NA	NA	NA	NA
COL6A6	131873	broad.mit.edu	37	3	130285632	130285633	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:130285632_130285633insC	uc010htl.2	+	4	1400_1401	c.1369_1370insC	c.(1369-1371)ACGfs	p.T457fs		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	457	VWFA 3.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TGAAATGAAGACGTTCCTGTCA	0.5			NA											27	133	---	---	---	---	NA	NA	NA	NA	NA
CLSTN2	64084	broad.mit.edu	37	3	140281113	140281113	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:140281113delG	uc003etn.2	+	13	2365	c.2175delG	c.(2173-2175)CTGfs	p.L725fs		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	725	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AACGACACCTGGATGCCACTA	0.527	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			19	103	---	---	---	---	NA	NA	NA	NA	NA
COMMD2	51122	broad.mit.edu	37	3	149470067	149470068	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr3:149470067_149470068insA	uc003exk.2	-	2	121_122	c.74_75insT	c.(73-75)GCCfs	p.A25fs		NM_016094	NP_057178	Q86X83	COMD2_HUMAN	COMM domain containing 2	25							protein binding				0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCCAAACTCGGCGACCACTGC	0.619			NA											26	168	---	---	---	---	NA	NA	NA	NA	NA
HELQ	113510	broad.mit.edu	37	4	84376684	84376698	+	In_Frame_Del	DEL	TTTTCCGCCTCCTGT	TTTTCCGCCTCCTGT	-	rs150006112	byFrequency	TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	TTTTCCGCCTCCTGT	TTTTCCGCCTCCTGT	-	-	TTTTCCGCCTCCTGT	TTTTCCGCCTCCTGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr4:84376684_84376698delTTTTCCGCCTCCTGT	uc003hom.2	-	1	328_342	c.149_163delACAGGAGGCGGAAAA	c.(148-165)AACAGGAGGCGGAAAACC>ACC	p.NRRRK50del	HELQ_uc010ikb.2_In_Frame_Del_p.NRRRK50del|HELQ_uc003hol.3_RNA|HELQ_uc010ikc.2_RNA|HELQ_uc003hon.1_5'UTR|HELQ_uc003hoo.1_In_Frame_Del_p.NRRRK50del|HELQ_uc003hop.1_5'UTR|HELQ_uc003hoq.1_In_Frame_Del_p.NRRRK50del|MRPS18C_uc003hor.3_5'Flank|MRPS18C_uc011ccu.1_5'Flank	NM_133636	NP_598375	Q8TDG4	HELQ_HUMAN	DNA helicase HEL308	50_54							ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(1)|breast(1)|skin(1)	3						ACGCCCGCGGTTTTCCGCCTCCTGTTCTCAGCCAC	0.6			NA						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function			OREG0016254	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	232	---	---	---	---	NA	NA	NA	NA	NA
ZNF623	9831	broad.mit.edu	37	8	144732931	144732931	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr8:144732931delG	uc003yzd.2	+	1	978	c.889delG	c.(889-891)GGGfs	p.G297fs	ZNF623_uc011lkp.1_Frame_Shift_Del_p.G257fs|ZNF623_uc003yzc.2_Frame_Shift_Del_p.G257fs	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	297	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CAAAGAATGTGGGAAGGCATT	0.453			NA											33	121	---	---	---	---	NA	NA	NA	NA	NA
NOTCH1	4851	broad.mit.edu	37	9	139396481	139396482	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chr9:139396481_139396482insC	uc004chz.2	-	29	5443_5444	c.5443_5444insG	c.(5443-5445)GACfs	p.D1815fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1815	Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CAGGTCCTCGTCCCCCCACTCA	0.673			NA	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			60	71	---	---	---	---	NA	NA	NA	NA	NA
OPHN1	4983	broad.mit.edu	37	X	67283757	67283757	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-1592-01A-01D-0969-08	TCGA-55-1592-11A-01D-0969-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1a09c2f5-cd26-4e6a-8993-c436312fdbb3	28c0bdc9-9dd1-4ce6-9254-e177f58970b8	g.chrX:67283757delG	uc004dww.3	-	21	2391	c.2097delC	c.(2095-2097)ACCfs	p.T699fs	OPHN1_uc011mpg.1_Intron	NM_002547	NP_002538	O60890	OPHN1_HUMAN	oligophrenin 1	699	Pro-rich.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(2)	2						AGGGGGTCTTGGTGGGCCCAG	0.617			NA											8	11	---	---	---	---	NA	NA	NA	NA	NA