Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SDF4	51150	broad.mit.edu	37	1	1158663	1158663	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:1158663C>T	uc001adh.3	-	4	867	c.538G>A	c.(538-540)GCC>ACC	p.A180T	SDF4_uc001adg.2_5'Flank|SDF4_uc001adi.3_Missense_Mutation_p.A180T|SDF4_uc009vjv.2_Missense_Mutation_p.A58T|SDF4_uc009vjw.2_RNA|SDF4_uc001adj.1_Missense_Mutation_p.A58T	NM_016176	NP_057260	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4 isoform 2	180					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|calcium ion binding|identical protein binding|protein binding			upper_aerodigestive_tract(1)|large_intestine(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		AGCCTGATGGCGTCGGCAACC	0.502			NA											20	111					0	0	0.000375601	0	0
RUNX3	864	broad.mit.edu	37	1	25229017	25229017	+	Missense_Mutation	SNP	C	C	A	rs149811022		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:25229017C>A	uc001bjq.2	-	5	1255	c.844G>T	c.(844-846)GCC>TCC	p.A282S	RUNX3_uc010oen.1_Missense_Mutation_p.A229S|RUNX3_uc009vrj.2_Missense_Mutation_p.A296S|RUNX3_uc001bjr.2_Missense_Mutation_p.A296S|RUNX3_uc001bjs.2_RNA	NM_004350	NP_004341	Q13761	RUNX3_HUMAN	runt-related transcription factor 3 isoform 2	282	Pro/Ser/Thr-rich.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GAGGGCGTGGCGCTGTAGGGG	0.692			NA											24	66					4.72057e-08	7.69108e-07	0.000586117	1	0
RCSD1	92241	broad.mit.edu	37	1	167654689	167654689	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:167654689C>T	uc001gem.2	+	3	327	c.140C>T	c.(139-141)CCG>CTG	p.P47L	RCSD1_uc010pli.1_Intron	NM_052862	NP_443094	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	47										ovary(2)|central_nervous_system(2)|skin(1)	5	all_hematologic(923;0.215)					CGAAGGAAACCGCCCTGTTCC	0.577			NA											7	46					0	0	8.12818e-05	0	0
TNR	7143	broad.mit.edu	37	1	175362964	175362964	+	Silent	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:175362964C>T	uc001gkp.1	-	4	1389	c.1308G>A	c.(1306-1308)GAG>GAA	p.E436E	TNR_uc009wwu.1_Silent_p.E436E|TNR_uc010pmz.1_3'UTR	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	436	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					ATGAGAAGGGCTCCCACTGCA	0.463			NA											15	173					0	0	0.000422831	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202391825	202391825	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:202391825C>T	uc001gya.1	+	3	644	c.500C>T	c.(499-501)CCA>CTA	p.P167L	PPP1R12B_uc001gxy.2_Missense_Mutation_p.P167L|PPP1R12B_uc009xad.1_Intron|PPP1R12B_uc009xae.1_Missense_Mutation_p.P167L|PPP1R12B_uc001gxz.1_Missense_Mutation_p.P167L	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	167					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAGAAGAGCCAGCCATGAAG	0.458			NA											13	61					0	0	0.000219431	0	0
OR14C36	127066	broad.mit.edu	37	1	248512522	248512522	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:248512522G>A	uc010pzl.1	+	1	446	c.446G>A	c.(445-447)AGT>AAT	p.S149N		NM_001001918	NP_001001918	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3						TCCCTACTCAGTGGTCTTGTC	0.527			NA											5	66					0	0	0.000602214	0	0
POLR3A	11128	broad.mit.edu	37	10	79779004	79779004	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:79779004T>C	uc001jzn.2	-	9	1299	c.1205A>G	c.(1204-1206)AAT>AGT	p.N402S		NM_007055	NP_008986	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	402					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding				0	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CCTCAAGAAATTGATGTTTGC	0.383			NA											9	50					0	0	0.000274275	0	0
DMBT1	1755	broad.mit.edu	37	10	124339221	124339221	+	Silent	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124339221T>C	uc001lgk.1	+	10	913	c.807T>C	c.(805-807)AAT>AAC	p.N269N	DMBT1_uc001lgl.1_Silent_p.N269N|DMBT1_uc001lgm.1_Silent_p.N269N|DMBT1_uc009xzz.1_Silent_p.N269N|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.N121N	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	269	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGATGCCAATGTGGTCTGCA	0.607	Ovarian(182;93 2026 18125 22222 38972)		NA											20	289					0	0	0.000375601	0	0
DMBT1	1755	broad.mit.edu	37	10	124339277	124339277	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124339277A>G	uc001lgk.1	+	10	969	c.863A>G	c.(862-864)CAG>CGG	p.Q288R	DMBT1_uc001lgl.1_Missense_Mutation_p.Q288R|DMBT1_uc001lgm.1_Missense_Mutation_p.Q288R|DMBT1_uc009xzz.1_Missense_Mutation_p.Q288R|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Missense_Mutation_p.Q140R	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	288	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGAAATGCCCAGTTTGGCCAG	0.607	Ovarian(182;93 2026 18125 22222 38972)		NA											7	172					0	0	0.000442599	0	0
DMBT1	1755	broad.mit.edu	37	10	124339284	124339284	+	Silent	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124339284C>T	uc001lgk.1	+	10	976	c.870C>T	c.(868-870)GGC>GGT	p.G290G	DMBT1_uc001lgl.1_Silent_p.G290G|DMBT1_uc001lgm.1_Silent_p.G290G|DMBT1_uc009xzz.1_Silent_p.G290G|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.G142G	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	290	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCCAGTTTGGCCAGGGCTCAG	0.597	Ovarian(182;93 2026 18125 22222 38972)		NA											7	149					0	0	0.000274275	0	0
DMBT1	1755	broad.mit.edu	37	10	124377716	124377716	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124377716A>G	uc001lgk.1	+	38	4794	c.4688A>G	c.(4687-4689)CAG>CGG	p.Q1563R	DMBT1_uc001lgl.1_Missense_Mutation_p.Q1553R|DMBT1_uc001lgm.1_Missense_Mutation_p.Q935R|DMBT1_uc009xzz.1_Missense_Mutation_p.Q1563R|DMBT1_uc010qtx.1_Missense_Mutation_p.Q414R|DMBT1_uc009yab.1_Missense_Mutation_p.Q266R|DMBT1_uc009yac.1_5'Flank	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	1563	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGAAATGCCCAGTTTGGCCAG	0.612	Ovarian(182;93 2026 18125 22222 38972)		NA											5	229					0	0	0.000157383	0	0
OR52E6	390078	broad.mit.edu	37	11	5862669	5862669	+	Silent	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:5862669C>T	uc010qzq.1	-	1	459	c.459G>A	c.(457-459)AGG>AGA	p.R153R	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	153	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTACAAGCTCCTCAGGACAG	0.483			NA											7	204					0	0	8.12818e-05	0	0
LRP4	4038	broad.mit.edu	37	11	46880755	46880755	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:46880755G>A	uc001ndn.3	-	38	5643	c.5497C>T	c.(5497-5499)CGG>TGG	p.R1833W	uc001ndl.2_Intron|LRP4_uc001ndm.3_Missense_Mutation_p.R75W	NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	1833	Cytoplasmic (Potential).				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		AGGCCCCCCCGTGAGCTTCGC	0.562			NA											22	68					0	0	0.000295444	0	0
LOC440040	440040	broad.mit.edu	37	11	49597962	49597962	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:49597962G>A	uc010rhy.1	+	2	553	c.75G>A	c.(73-75)AGG>AGA	p.R25R	LOC440040_uc009ymb.2_Silent_p.R25R	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						TTCATGAGAGGAAGTGTGGGG	0.522			NA											4	23					0	0	0.000602214	0	0
PIWIL4	143689	broad.mit.edu	37	11	94316616	94316616	+	Silent	SNP	C	C	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:94316616C>A	uc001pfa.2	+	5	727	c.516C>A	c.(514-516)GTC>GTA	p.V172V	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	172					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				TTTCCCAGGTCACAGAGTTGT	0.418			NA											32	186					1.80694e-10	3.0176e-09	0.000279167	1	0
Unknown	0	broad.mit.edu	37	12	31307356	31307356	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:31307356T>C	uc010sjy.1	-	7	724	c.724A>G	c.(724-726)AAA>GAA	p.K242E						RecName: Full=Ovostatin homolog 1; Flags: Precursor;												NA						ATTTGGGTTTTCCCTTGCACA	0.383			NA											4	18					0	0	0.00024832	0	0
CDK4	1019	broad.mit.edu	37	12	58145430	58145430	+	Missense_Mutation	SNP	C	C	A	rs104894340		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:58145430C>A	uc001spv.2	-	2	298	c.71G>T	c.(70-72)CGT>CTT	p.R24L	CDK4_uc010ssb.1_5'UTR|CDK4_uc001spw.2_RNA|uc010ssc.1_RNA	NM_000075	NP_000066	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	24	Protein kinase.		R -> H (in CMM3).		cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding			lung(1)|breast(1)|central_nervous_system(1)	3	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GTGGGGATCACGGGCCTTGTA	0.557			NA	Mis			melanoma 			Hereditary_Melanoma				13	29					4.3838e-07	6.97233e-06	0.000151284	1	0
SVOP	55530	broad.mit.edu	37	12	109309580	109309580	+	Silent	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:109309580G>C	uc010sxh.1	-	14	1591	c.1419C>G	c.(1417-1419)CTC>CTG	p.L473L		NM_018711	NP_061181	Q8N4V2	SVOP_HUMAN	SV2 related protein	473	Helical; (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity				0						ACGGAGTGATGAGAGCACCCA	0.557			NA											4	14					0	0	0.000602214	0	0
HVCN1	84329	broad.mit.edu	37	12	111099246	111099246	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:111099246G>A	uc001trs.1	-	4	194	c.29C>T	c.(28-30)ACC>ATC	p.T10I	HVCN1_uc001trq.1_Missense_Mutation_p.T10I|HVCN1_uc001trt.1_Missense_Mutation_p.T10I|HVCN1_uc010syd.1_5'UTR	NM_032369	NP_115745	Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	10	Cytoplasmic (Potential).				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			skin(1)	1						GGCCCTGCGGGTGACTGCCTA	0.602			NA											5	25					0	0	0.000602214	0	0
DIAPH3	81624	broad.mit.edu	37	13	60545013	60545013	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr13:60545013G>C	uc001vht.2	-	16	2151	c.1932C>G	c.(1930-1932)ATC>ATG	p.I644M	DIAPH3_uc001vhu.2_Missense_Mutation_p.I381M|DIAPH3_uc001vhv.2_Missense_Mutation_p.I222M	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	644	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTCTCATGCTGATTTCAGGTT	0.338			NA											5	40					0	0	8.12818e-05	0	0
IPO4	79711	broad.mit.edu	37	14	24652208	24652208	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:24652208C>T	uc001wmv.1	-	23	2526	c.2395G>A	c.(2395-2397)GTG>ATG	p.V799M	IPO4_uc001wmt.1_Missense_Mutation_p.V277M|IPO4_uc001wmu.2_Missense_Mutation_p.V461M|IPO4_uc001wmx.1_Missense_Mutation_p.V663M|IPO4_uc001wmy.1_Missense_Mutation_p.V663M|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Missense_Mutation_p.V799M	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	799					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		GCCTTGAGCACGCCACAGAGC	0.677			NA											15	56					0	0	0.000219431	0	0
G2E3	55632	broad.mit.edu	37	14	31077238	31077238	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:31077238A>G	uc001wqk.2	+	12	1617	c.1463A>G	c.(1462-1464)GAT>GGT	p.D488G	G2E3_uc010tpe.1_3'UTR|G2E3_uc010tpf.1_Missense_Mutation_p.D442G	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	488	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						ATTTTAGATGATGTTTCAGAC	0.343			NA											10	106					0	0	0.000151284	0	0
GNPNAT1	64841	broad.mit.edu	37	14	53250176	53250176	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:53250176G>C	uc001xab.2	-	3	437	c.182C>G	c.(181-183)ACA>AGA	p.T61R		NM_198066	NP_932332	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	61	N-acetyltransferase.	Substrate.			dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity				0	Breast(41;0.176)					TCCAGTCTCTGTTAGCTGACC	0.318			NA											3	95					0	0	0.000602214	0	0
TRMT5	57570	broad.mit.edu	37	14	61446337	61446337	+	Silent	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:61446337T>C	uc001xff.3	-	2	370	c.279A>G	c.(277-279)ACA>ACG	p.T93T	SLC38A6_uc001xfg.1_5'Flank|SLC38A6_uc001xfh.1_5'Flank|SLC38A6_uc001xfi.2_5'Flank|SLC38A6_uc001xfj.1_5'Flank|SLC38A6_uc001xfk.2_5'Flank|SLC38A6_uc010trz.1_5'Flank	NM_020810	NP_065861	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	93						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			central_nervous_system(2)|large_intestine(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		GAATGTTGACTGTCTTTTTAA	0.423			NA											15	192					0	0	0.000566183	0	0
ATG2B	55102	broad.mit.edu	37	14	96811066	96811066	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:96811066A>C	uc001yfi.2	-	4	871	c.506T>G	c.(505-507)ATA>AGA	p.I169R		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	169										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AACAGTATCTATAAAAGTGAC	0.294			NA											6	32					0	0	0.000274275	0	0
RAB40C	57799	broad.mit.edu	37	16	675984	675984	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:675984C>T	uc002chr.2	+	5	544	c.428C>T	c.(427-429)GCG>GTG	p.A143V	RAB40C_uc002chq.2_Missense_Mutation_p.A124V	NM_021168	NP_066991	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	143					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0		Hepatocellular(780;0.0218)				CAGGCCCGCGCGTACGCAGAG	0.617	Melanoma(123;1631 1690 28262 44104 44957)		NA											11	31					0	0	6.40141e-05	0	0
CPPED1	55313	broad.mit.edu	37	16	12875100	12875100	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:12875100C>G	uc002dca.3	-	2	342	c.231G>C	c.(229-231)AAG>AAC	p.K77N	CPPED1_uc002dcb.3_Missense_Mutation_p.K77N	NM_018340	NP_060810	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain	77				K -> E (in Ref. 2; BAA92034).			hydrolase activity|metal ion binding				0						TGGGGTTCAGCTTGTTGATGG	0.562			NA											3	41					0	0	6.4e-05	0	0
CACNG3	10368	broad.mit.edu	37	16	24268206	24268206	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:24268206C>G	uc002dmf.2	+	1	1331	c.131C>G	c.(130-132)TCT>TGT	p.S44C		NM_006539	NP_006530	O60359	CCG3_HUMAN	voltage-dependent calcium channel gamma-3	44					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0				GBM - Glioblastoma multiforme(48;0.0809)		AGGACTAAATCTACAAGTGAT	0.453			NA											3	86					0	0	0.00024832	0	0
TUFM	7284	broad.mit.edu	37	16	28855408	28855408	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:28855408G>A	uc002drh.2	-	8	1076	c.937C>T	c.(937-939)CAC>TAC	p.H313Y	uc010vct.1_Intron|SH2B1_uc002dri.2_5'Flank	NM_003321	NP_003312	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	310						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			ovary(1)	1						AGGCTCTTGTGGAACATCTCA	0.622			NA											11	62					0	0	0.000673444	0	0
CDYL2	124359	broad.mit.edu	37	16	80718848	80718848	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:80718848G>C	uc002ffs.2	-	2	308	c.203C>G	c.(202-204)TCA>TGA	p.S68*		NM_152342	NP_689555	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	68						nucleus	catalytic activity|protein binding			central_nervous_system(1)	1						CTGCTTCCCTGACTTGATCCT	0.547			NA											22	74					0	0	0.000586117	0	0
FLOT2	2319	broad.mit.edu	37	17	27208290	27208290	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr17:27208290G>A	uc002hdc.2	-	9	1141	c.1018C>T	c.(1018-1020)CGG>TGG	p.R340W		NM_004475	NP_004466	Q14254	FLOT2_HUMAN	flotillin 2	340					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction					0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			AGCTTCATCCGCTCAGCCTCT	0.612			NA											9	39					0	0	0.000673444	0	0
Unknown	0	broad.mit.edu	37	17	43617325	43617325	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr17:43617325A>T	uc002ijh.2	-	4	1181	c.1060T>A	c.(1060-1062)TTA>ATA	p.L354I	uc010wjv.1_RNA					Homo sapiens cDNA FLJ45049 fis, clone BRAWH3022347.												NA						TTGCAGGATAAATCTCTAGGA	0.264			NA											6	88					0	0	8.12818e-05	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655855	48655855	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr17:48655855A>G	uc002irk.1	+	9	2603	c.2231A>G	c.(2230-2232)TAC>TGC	p.Y744C	CACNA1G_uc002iri.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irj.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irl.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irm.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irn.1_Missense_Mutation_p.Y744C|CACNA1G_uc002iro.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irp.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irq.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irr.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irs.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irt.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irv.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irw.1_Missense_Mutation_p.Y744C|CACNA1G_uc002iru.1_Missense_Mutation_p.Y744C|CACNA1G_uc002irx.1_Missense_Mutation_p.Y657C|CACNA1G_uc002iry.1_Missense_Mutation_p.Y657C|CACNA1G_uc002irz.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isa.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isb.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isc.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isd.1_Missense_Mutation_p.Y657C|CACNA1G_uc002ise.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isf.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isg.1_Missense_Mutation_p.Y657C|CACNA1G_uc002ish.1_Missense_Mutation_p.Y657C|CACNA1G_uc002isi.1_Missense_Mutation_p.Y657C	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	744	Helical; Name=S1 of repeat II; (Potential).|II.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GACAGCAAGTACTTTGGCCGG	0.592			NA											6	66					0	0	3.59834e-05	0	0
DSG3	1830	broad.mit.edu	37	18	29044158	29044158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr18:29044158C>T	uc002kws.2	+	9	1193	c.1084C>T	c.(1084-1086)CGA>TGA	p.R362*		NM_001944	NP_001935	P32926	DSG3_HUMAN	desmoglein 3 preproprotein	362	Cadherin 3.|Extracellular (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			skin(4)|ovary(3)|lung(1)|central_nervous_system(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGTTATCTCTCGATACCGAGT	0.378			NA											13	45					0	0	0.000219431	0	0
KIR2DS4	3809	broad.mit.edu	37	19	55344253	55344253	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr19:55344253G>T	uc002qhm.1	+	1	80	c.34G>T	c.(34-36)GGG>TGG	p.G12W	KIR2DS4_uc010yfj.1_Intron|KIR2DS4_uc010yfk.1_Intron|KIR3DL1_uc002qhl.3_Intron|KIR2DS4_uc010esg.1_Missense_Mutation_p.G12W	NM_012314	NP_036446	P43632	KI2S4_HUMAN	killer cell immunoglobulin-like receptor, two	12						integral to plasma membrane	receptor activity				0				GBM - Glioblastoma multiforme(193;0.0192)		GGCGTGTGTTGGTGAGTCCTG	0.612			NA											10	155					1.58986e-06	2.49889e-05	0.000673444	1	0
PRKD3	23683	broad.mit.edu	37	2	37543552	37543552	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:37543552C>T	uc002rqd.2	-	1	671	c.116G>A	c.(115-117)CGA>CAA	p.R39Q	PRKD3_uc002rqf.1_Missense_Mutation_p.R39Q	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	39					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				ATTAGAGAGTCGGGCAGAGAG	0.517	Melanoma(80;621 1355 8613 11814 51767)		NA											7	83					0	0	8.12818e-05	0	0
REL	5966	broad.mit.edu	37	2	61149499	61149499	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:61149499G>T	uc002sam.1	+	11	1913	c.1689G>T	c.(1687-1689)GAG>GAT	p.E563D	REL_uc002san.1_Missense_Mutation_p.E531D	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	563					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			ATGCATTTGAGGGATCTGACT	0.418			NA	A		Hodgkin Lymphoma								21	102					1.96292e-10	3.23761e-09	0.000175454	1	0
RGPD4	285190	broad.mit.edu	37	2	108488724	108488724	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:108488724G>C	uc010ywk.1	+	20	4346	c.4264G>C	c.(4264-4266)GGG>CGG	p.G1422R	RGPD4_uc002tdu.2_Missense_Mutation_p.G609R|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1422	RanBD1 2.				intracellular transport		binding			skin(2)	2						AAATATGAAAGGGACAGAAAG	0.378			NA											21	328					0	0	0.000375601	0	0
TMEM177	80775	broad.mit.edu	37	2	120439204	120439204	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:120439204G>C	uc010flg.1	+	2	1248	c.775G>C	c.(775-777)GCC>CCC	p.A259P	TMEM177_uc002tme.2_Intron|TMEM177_uc002tmc.1_Missense_Mutation_p.A259P|TMEM177_uc002tmd.2_Missense_Mutation_p.A259P|TMEM177_uc010flh.2_Intron	NM_001105198	NP_001098668	Q53S58	TM177_HUMAN	transmembrane protein 177	259						integral to membrane				ovary(1)	1	Colorectal(110;0.196)					GGGCAACCTGGCCCTGCGCAG	0.587			NA											7	50					0	0	8.12818e-05	0	0
TANK	10010	broad.mit.edu	37	2	162036222	162036222	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:162036222C>T	uc002ubr.1	+	2	207	c.49C>T	c.(49-51)CGG>TGG	p.R17W	TANK_uc002ubq.1_Missense_Mutation_p.R17W|TANK_uc002ubs.2_Missense_Mutation_p.R17W	NM_004180	NP_004171	Q92844	TANK_HUMAN	TRAF interacting protein TANK isoform a	17						cytosol	metal ion binding|protein binding			ovary(1)	1						TGAAGCCTTCCGGCAGGCATG	0.403			NA											4	30					0	0	0.000602214	0	0
DNAJC10	54431	broad.mit.edu	37	2	183584806	183584806	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:183584806C>T	uc002uow.1	+	4	692	c.277C>T	c.(277-279)CGG>TGG	p.R93W	DNAJC10_uc002uox.1_RNA|DNAJC10_uc002uoy.1_RNA|DNAJC10_uc002uoz.1_Missense_Mutation_p.R93W|DNAJC10_uc010fro.1_RNA	NM_018981	NP_061854	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	93	J.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			ovary(1)|large_intestine(1)|breast(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGAAGATCTACGGAAAAAGTA	0.313	Pancreas(56;860 1183 25669 35822 48585)		NA											6	56					0	0	8.12818e-05	0	0
COL4A4	1286	broad.mit.edu	37	2	227872966	227872966	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:227872966T>C	uc010zlt.1	-	46	5231	c.4577A>G	c.(4576-4578)AAC>AGC	p.N1526S		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1526	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTGGTGGATGTTGCAGTAGGC	0.582			NA											3	33					0	0	6.4e-05	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545643	234545643	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:234545643A>G	uc002vur.2	+	1	521	c.475A>G	c.(475-477)AAA>GAA	p.K159E	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Missense_Mutation_p.K159E	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	159					flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		AATTGTTGCTAAATATTTCTC	0.423			NA											26	132					0	0	0.000227799	0	0
GPR35	2859	broad.mit.edu	37	2	241569479	241569479	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:241569479T>G	uc002vzs.1	+	1	685	c.110T>G	c.(109-111)CTC>CGC	p.L37R	GPR35_uc010fzh.1_Missense_Mutation_p.L68R|GPR35_uc010fzi.1_Missense_Mutation_p.L68R	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	37	Helical; Name=1; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GGCCTGCTGCTCAACAGCCTG	0.642			NA											5	50					0	0	0.000602214	0	0
ZNF341	84905	broad.mit.edu	37	20	32378868	32378868	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr20:32378868G>A	uc002wzy.2	+	15	2130	c.2110G>A	c.(2110-2112)GCC>ACC	p.A704T	ZNF341_uc002wzx.2_Missense_Mutation_p.A697T|ZNF341_uc010geq.2_Missense_Mutation_p.A614T|ZNF341_uc010ger.2_RNA|ZNF341_uc002wzz.2_Missense_Mutation_p.A131T	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	704	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GCATCAGCGCGCCCACACGGG	0.612			NA											5	35					0	0	0.000602214	0	0
NCOA5	57727	broad.mit.edu	37	20	44691001	44691001	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr20:44691001G>C	uc002xrd.2	-	7	2206	c.1678C>G	c.(1678-1680)CAG>GAG	p.Q560E	NCOA5_uc002xrc.2_3'UTR|NCOA5_uc002xre.2_Missense_Mutation_p.Q560E	NM_020967	NP_066018	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	560	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				GCTGTGGTCTGGCTAACCAGG	0.547			NA											4	30					0	0	0.000602214	0	0
UMODL1	89766	broad.mit.edu	37	21	43522353	43522353	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr21:43522353G>A	uc002zaf.1	+	8	1264	c.1264G>A	c.(1264-1266)GAG>AAG	p.E422K	UMODL1_uc002zad.1_Missense_Mutation_p.E350K|UMODL1_uc002zae.1_Missense_Mutation_p.E350K|UMODL1_uc002zag.1_Missense_Mutation_p.E422K|UMODL1_uc010gow.1_Missense_Mutation_p.E214K|UMODL1_uc002zai.1_Missense_Mutation_p.E73K|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_Missense_Mutation_p.E73K|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.E167K|C21orf128_uc002zak.2_3'UTR	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	422	Extracellular (Potential).|SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						CAGCAGTGTGGAGTACCAGGA	0.438	Pancreas(122;680 807 13940 14411 22888 25505 31742 36028 36332 38435)		NA											8	144					0	0	0.000274275	0	0
PCBP3	54039	broad.mit.edu	37	21	47360050	47360050	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr21:47360050G>A	uc002zhq.1	+	13	1141	c.1016G>A	c.(1015-1017)CGT>CAT	p.R339H	PCBP3_uc002zhp.1_Missense_Mutation_p.R319H|PCBP3_uc002zhs.1_Missense_Mutation_p.R313H|PCBP3_uc002zhr.1_Missense_Mutation_p.R338H|PCBP3_uc002zht.1_Missense_Mutation_p.R329H	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	339	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TCCTCAGAGCGTCAGATCACC	0.557			NA											11	46					0	0	6.40141e-05	0	0
IL2RB	3560	broad.mit.edu	37	22	37524438	37524438	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr22:37524438C>T	uc003aqv.1	-	10	1485	c.1354G>A	c.(1354-1356)GAA>AAA	p.E452K		NM_000878	NP_000869	P14784	IL2RB_HUMAN	interleukin 2 receptor beta precursor	452	Cytoplasmic (Potential).				interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity				0					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ATCCTCTCTTCACCGGCCCCA	0.667			NA											9	10					0	0	0.000442599	0	0
SCN5A	6331	broad.mit.edu	37	3	38674694	38674694	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr3:38674694G>A	uc003cio.2	-	2	299	c.105C>T	c.(103-105)GGC>GGT	p.G35G	SCN5A_uc003cin.2_Silent_p.G35G|SCN5A_uc003cil.3_Silent_p.G35G|SCN5A_uc010hhi.2_Silent_p.G35G|SCN5A_uc010hhk.2_Silent_p.G35G|SCN5A_uc011ayr.1_Silent_p.G35G	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	35					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGTGGTTGAGCCGCGGGCTT	0.637			NA											3	16					0	0	6.4e-05	0	0
BSN	8927	broad.mit.edu	37	3	49692949	49692949	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr3:49692949C>T	uc003cxe.3	+	5	6074	c.5960C>T	c.(5959-5961)ACC>ATC	p.T1987I		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	1987					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ATGTCTGACACCAATTTGGCT	0.627			NA											4	29					0	0	0.000602214	0	0
ECT2	1894	broad.mit.edu	37	3	172480505	172480505	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr3:172480505A>T	uc003fii.2	+	9	959	c.821A>T	c.(820-822)GAT>GTT	p.D274V	ECT2_uc010hwv.1_Missense_Mutation_p.D305V|ECT2_uc003fih.2_Missense_Mutation_p.D273V|ECT2_uc003fij.1_Missense_Mutation_p.D274V|ECT2_uc003fik.1_Missense_Mutation_p.D274V|ECT2_uc003fil.1_Missense_Mutation_p.D305V	NM_018098	NP_060568	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	274	BRCT 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|ovary(1)|skin(1)	4	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CCGCTTGGAGATGAAAGATGC	0.333			NA											4	52					0	0	3.59834e-05	0	0
WHSC1	7468	broad.mit.edu	37	4	1961302	1961303	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr4:1961302_1961303GG>TC	uc003gdz.3	+	17	3266_3267	c.3090_3091GG>TC	c.(3088-3093)TCGGAG>TCTCAG	p.E1031Q	WHSC1_uc003geb.3_Missense_Mutation_p.E1031Q|WHSC1_uc003gec.3_Missense_Mutation_p.E1031Q|WHSC1_uc003ged.3_Missense_Mutation_p.E1031Q|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.E250Q|WHSC1_uc011bvh.1_Missense_Mutation_p.E92Q|WHSC1_uc010icf.2_Missense_Mutation_p.E379Q	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1031	AWS.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GCTTTGATTCGGAGTGTCTGAA	0.525			NA	T	IGH@	MM								11	51					0	0	6.4e-05	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630087	9630087	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr5:9630087C>A	uc003jem.1	-	1	377	c.58G>T	c.(58-60)GGG>TGG	p.G20W		NM_019599	NP_062545	Q9NYW7	TA2R1_HUMAN	taste receptor T2R1	20	Helical; Name=1; (Potential).				chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			ovary(3)	3						GTGAAAATCCCAAGAAGAAAT	0.343			NA											20	56					8.10497e-08	1.30461e-06	0.000175454	1	0
ISL1	3670	broad.mit.edu	37	5	50683467	50683467	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr5:50683467C>T	uc003jor.2	+	3	910	c.362C>T	c.(361-363)GCG>GTG	p.A121V		NM_002202	NP_002193	P61371	ISL1_HUMAN	islet-1	121	LIM zinc-binding 2.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3		Lung NSC(810;0.000845)|Breast(144;0.0411)				GACGAATTTGCGCTTCGGGAG	0.632			NA											7	30					0	0	8.12818e-05	0	0
FAT2	2196	broad.mit.edu	37	5	150931118	150931118	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr5:150931118G>A	uc003lue.3	-	6	4219	c.4206C>T	c.(4204-4206)ATC>ATT	p.I1402I	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1402	Extracellular (Potential).|Cadherin 12.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGCAATGACGATGCTGCCTG	0.522			NA											7	63					0	0	0.000274275	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32918314	32918314	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr6:32918314T>C	uc003ocm.2	-	2	441	c.355A>G	c.(355-357)AAA>GAA	p.K119E	HLA-DMA_uc011dqm.1_Missense_Mutation_p.K119E	NM_006120	NP_006111	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM	119						integral to membrane|MHC class II protein complex					0						ACCGGGATTTTCCCATCAAGT	0.488			NA											9	209					0	0	0.000442599	0	0
TAAR5	9038	broad.mit.edu	37	6	132910007	132910007	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr6:132910007C>T	uc003qdk.2	-	1	871	c.819G>A	c.(817-819)ATG>ATA	p.M273I		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	273	Helical; Name=6; (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GGCTGTCGACCATCGTGTCTA	0.517			NA											11	90					0	0	6.40141e-05	0	0
NOD1	10392	broad.mit.edu	37	7	30491515	30491515	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:30491515G>A	uc003tav.2	-	6	2041	c.1518C>T	c.(1516-1518)CCC>CCT	p.P506P		NM_006092	NP_006083	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain	506	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			ovary(1)|skin(1)	2						GGTCACCCCCGGGGCCCAGCT	0.627			NA											7	56					0	0	0.000274275	0	0
KIAA0895	23366	broad.mit.edu	37	7	36373544	36373544	+	Silent	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:36373544G>T	uc003tfd.2	-	5	1278	c.1227C>A	c.(1225-1227)GGC>GGA	p.G409G	KIAA0895_uc003tfc.2_Silent_p.G396G|KIAA0895_uc011kaw.1_Silent_p.G306G|KIAA0895_uc003tfb.2_Silent_p.G358G|KIAA0895_uc011kax.1_Silent_p.G406G	NM_001100425	NP_001093895	Q8NCT3	K0895_HUMAN	hypothetical protein LOC23366 isoform 1	409											0						TGACAAACCTGCCAATATCTT	0.448			NA											6	122					2.0095e-06	3.12173e-05	8.12818e-05	1	0
OGDH	4967	broad.mit.edu	37	7	44687313	44687313	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:44687313G>T	uc003tln.2	+	4	581	c.472G>T	c.(472-474)GAC>TAC	p.D158Y	OGDH_uc003tlm.2_Missense_Mutation_p.D158Y|OGDH_uc011kbx.1_Intron|OGDH_uc011kby.1_Intron|OGDH_uc003tlp.2_Intron|OGDH_uc011kbz.1_Missense_Mutation_p.W4C|OGDH_uc003tlo.1_5'UTR	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	158					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	TGCTGATCTGGACTCCTCCGT	0.557			NA											18	148					1.10513e-12	1.86893e-11	0.000295444	1	0
MAGI2	9863	broad.mit.edu	37	7	77764449	77764449	+	Silent	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:77764449G>T	uc003ugx.2	-	17	3174	c.2920C>A	c.(2920-2922)CGG>AGG	p.R974R	MAGI2_uc003ugy.2_Silent_p.R960R|MAGI2_uc010ldx.1_Silent_p.R567R	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	974	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GCTAGGATCCGGTCTCCCACT	0.483			NA											5	159					8.12818e-05	0.00124819	8.12818e-05	1	0
MOGAT3	346606	broad.mit.edu	37	7	100843556	100843556	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:100843556G>A	uc003uyc.2	-	3	414	c.247C>T	c.(247-249)CGG>TGG	p.R83W	MOGAT3_uc010lhr.2_Missense_Mutation_p.R83W	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	83					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					CAAATTGCCCGGTTCCTTATC	0.562			NA											29	200					0	0	0.000409698	0	0
ADAM18	8749	broad.mit.edu	37	8	39564352	39564352	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr8:39564352G>A	uc003xni.2	+	18	1946	c.1946G>A	c.(1945-1947)AGA>AAA	p.R649K	ADAM18_uc010lww.2_RNA|ADAM18_uc010lwx.2_Missense_Mutation_p.R625K	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18	649	EGF-like.|Extracellular (Potential).				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CCTGGACATAGACCTCCAGAT	0.348			NA											21	58					0	0	0.000295444	0	0
FZD6	8323	broad.mit.edu	37	8	104331000	104331000	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr8:104331000G>A	uc003ylh.2	+	3	644	c.360G>A	c.(358-360)GAG>GAA	p.E120E	FZD6_uc003yli.2_Silent_p.E120E|FZD6_uc003ylj.2_Silent_p.E120E|FZD6_uc011lhn.1_Silent_p.E86E|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Silent_p.E65E	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	120	FZ.|Extracellular (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			GGCCTGAGGAGCTTGAATGTG	0.368			NA											6	44					0	0	3.59834e-05	0	0
ZNF462	58499	broad.mit.edu	37	9	109773236	109773236	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr9:109773236G>C	uc004bcz.2	+	13	7735	c.7446G>C	c.(7444-7446)AAG>AAC	p.K2482N	ZNF462_uc010mto.2_Missense_Mutation_p.K2391N|ZNF462_uc004bda.2_Missense_Mutation_p.K2390N|ZNF462_uc011lvz.1_Missense_Mutation_p.K439N|uc004bdc.1_Intron	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2482					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						TTTCCCTAAAGAATGAAACAG	0.413			NA											6	19					0	0	8.12818e-05	0	0
RABEPK	10244	broad.mit.edu	37	9	127969995	127969995	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr9:127969995A>G	uc004bpi.2	+	4	379	c.206A>G	c.(205-207)GAT>GGT	p.D69G	RABEPK_uc004bph.1_Missense_Mutation_p.D69G|RABEPK_uc004bpj.2_Missense_Mutation_p.D69G|RABEPK_uc004bpk.2_Missense_Mutation_p.D69G|RABEPK_uc004bpl.1_Missense_Mutation_p.D69G|RABEPK_uc004bpm.2_Missense_Mutation_p.D69G	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	69	Kelch 1.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						CACACCATGGATCTGGGTAAG	0.507			NA											10	78					0	0	0.000673444	0	0
FLJ44635	392490	broad.mit.edu	37	X	71380019	71380019	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:71380019A>C	uc004eal.1	+	2	688	c.340A>C	c.(340-342)AAA>CAA	p.K114Q		NM_207422	NP_997305	Q56UQ5	TPT1L_HUMAN	hypothetical protein LOC392490	114										lung(1)	1	Renal(35;0.156)					ACAGAGACCAAAAAGAGTAAA	0.378			NA											9	98					0	0	0.000442599	0	0
LPAR4	2846	broad.mit.edu	37	X	78010493	78010493	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:78010493G>A	uc010nme.2	+	2	532	c.127G>A	c.(127-129)GGT>AGT	p.G43S		NM_005296	NP_005287	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	43	Extracellular (Potential).					integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			ovary(3)	3						TAATCTCAATGGTGCTGTCTA	0.408			NA											21	261					0	0	0.000295444	0	0
MCTS1	28985	broad.mit.edu	37	X	119739377	119739377	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:119739377A>G	uc004esx.2	+	2	475	c.127A>G	c.(127-129)ATC>GTC	p.I43V	MCTS1_uc011mub.1_Missense_Mutation_p.I44V	NM_014060	NP_054779	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1 isoform 1	43					cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding				0						GCTTAATCAAATCATGCCTAA	0.343			NA											4	139					0	0	0.00024832	0	0
GRIA3	2892	broad.mit.edu	37	X	122598956	122598956	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:122598956G>C	uc004etq.3	+	14	2610	c.2317G>C	c.(2317-2319)GCA>CCA	p.A773P	GRIA3_uc004etr.3_Missense_Mutation_p.A773P|GRIA3_uc004ets.3_RNA	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	773	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	TAAAGGCTCAGCATTAAGGTG	0.398			NA											5	75					0	0	0.000602214	0	0
PRPF40A	55660	broad.mit.edu	37	2	153547493	153547494	+	Splice_Site	INS	-	-	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:153547493_153547494insA	uc002tyi.2	-	5	423	c.410_splice	c.e5-1	p.G137_splice	PRPF40A_uc002tyh.3_Splice_Site_p.G110_splice|PRPF40A_uc010zcd.1_Intron|PRPF40A_uc002tyj.2_Splice_Site_p.G6_splice|PRPF40A_uc002tyl.1_Splice_Site_p.G137_splice	NM_017892	NP_060362	O75400	PR40A_HUMAN	formin binding protein 3						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding				0						GATGCTGTACCTAAAAAATAAA	0.267			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55242468	55242482	+	In_Frame_Del	DEL	ATTAAGAGAAGCAAC	ATTAAGAGAAGCAAC	-	rs121913435		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	ATTAAGAGAAGCAAC	ATTAAGAGAAGCAAC	-	-	ATTAAGAGAAGCAAC	ATTAAGAGAAGCAAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:55242468_55242482delATTAAGAGAAGCAAC	uc003tqk.2	+	19	2484_2498	c.2238_2252delATTAAGAGAAGCAAC	c.(2236-2253)GAATTAAGAGAAGCAACA>GAA	p.LREAT747del	EGFR_uc010kzg.1_In_Frame_Del_p.LREAT702del|EGFR_uc011kco.1_In_Frame_Del_p.LREAT694del	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	747_751	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1613)|p.L747_P753>S(166)|p.L747_A750>P(115)|p.L747_T751del(114)|p.E746_S752>V(67)|p.L747_S752del(64)|p.L747_T751>P(33)|p.E746_T751>A(30)|p.L747_E749del(26)|p.L747_P753del(21)|p.L747_P753>Q(19)|p.E746_T751del(18)|p.K745_E749del(14)|p.L747_T751>S(12)|p.E746_E749del(12)|p.L747_A750del(11)|p.E746_S752del(10)|p.L747_T751>Q(7)|p.E746_P753>VS(6)|p.T751_I759>N(5)|p.E746_A750>IP(5)|p.L747P(5)|p.E746_T751>I(5)|p.E746_T751>V(5)|p.E746_S752>A(5)|p.E746_T751>IP(5)|p.T751I(5)|p.L747S(4)|p.E746_A750>QP(4)|p.E746_S752>D(4)|p.K745_A750del(4)|p.T751_I759>S(3)|p.L747_S752>Q(3)|p.A750P(3)|p.L747del(3)|p.E746_T751>VA(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.E746_A750>S(2)|p.L747_S752>QH(2)|p.E746_T751>L(2)|p.L747_T751>A(2)|p.A750_E758>P(2)|p.E746_T751>Q(2)|p.E746_T751>S(2)|p.E746_A750>DP(2)|p.E746_S752>T(2)|p.E746_P753del(2)|p.E746_S752>I(2)|p.E746_A750>AP(2)|p.L747_K754>ST(1)|p.E746_A750>A(1)|p.A750_K754del(1)|p.E746_A750>VP(1)|p.L747_K754>N(1)|p.L747_A755del(1)|p.E746_A750>EP(1)|p.L747_R748>FP(1)|p.K745_L747del(1)|p.L747_S752>V(1)|p.L747_N756>SKDD(1)|p.L747_E749>C(1)|p.E746_P753>LS(1)|p.L747_T751>F(1)|p.E746_P753>VQ(1)|p.L747_P753>CG(1)|p.E746_T751>LS(1)|p.A750_E758del(1)|p.E746V(1)|p.E746_R748del(1)|p.I744_A750>VK(1)|p.E746_T751>P(1)|p.L747_K754del(1)|p.R748I(1)|p.L747_T751>N(1)|p.E746_A750>KP(1)|p.T751_I759>REA(1)|p.L747_S752>QR(1)|p.L747_K754>GC(1)|p.T751_E758del(1)|p.L747_A755>SKS(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTATCAAGGAATTAAGAGAAGCAACATCTCCGAAA	0.479		E746_A750del(NCIH1650_LUNG)|L747_P753>Q(HCC4006_LUNG)|E746_A750del(PC14_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			66	108	---	---	---	---	NA	NA	NA	NA	NA
KIAA1429	25962	broad.mit.edu	37	8	95538800	95538800	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr8:95538800delG	uc003ygo.1	-	8	1685	c.1672delC	c.(1672-1674)CATfs	p.H558fs	KIAA1429_uc003ygp.2_Frame_Shift_Del_p.H558fs|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	558					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCATAGAAATGGCATTTTTGG	0.398			NA											50	118	---	---	---	---	NA	NA	NA	NA	NA