Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
EXTL1	2134	broad.mit.edu	37	1	26357639	26357639	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:26357639T>G	uc001blf.2	+	5	1985	c.1118T>G	c.(1117-1119)ATT>AGT	p.I373S		NM_004455	NP_004446	Q92935	EXTL1_HUMAN	exostoses-like 1	373	Lumenal (Potential).				skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGACCGGATTTTTGGAACA	0.587			NA											20	92					0	0	0.014323	0	0
NBPF14	25832	broad.mit.edu	37	1	148009403	148009403	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:148009403T>C	uc001eqq.2	-	16	1921	c.1904A>G	c.(1903-1905)TAC>TGC	p.Y635C	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.Y208C|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	635	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					GGCACTTCTGTAGGGCTGGCA	0.468			NA											31	341					0	0	0.004289	0	0
GPA33	10223	broad.mit.edu	37	1	167042703	167042703	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:167042703G>A	uc001gea.1	-	2	461	c.117C>T	c.(115-117)GTC>GTT	p.V39V		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	39	Ig-like V-type.|Extracellular (Potential).					integral to plasma membrane	receptor activity				0						AGGGCAGGGTGACACTCTTTC	0.532			NA											12	33					0	0	0.013537	0	0
PRRX1	5396	broad.mit.edu	37	1	170705309	170705309	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:170705309G>A	uc001ghf.2	+	4	767	c.720G>A	c.(718-720)CAG>CAA	p.Q240Q	PRRX1_uc001ghe.2_3'UTR	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	240						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGAGGAACCAGGTGCCAACAG	0.433			NA											34	72					0	0	0.010818	0	0
HMCN1	83872	broad.mit.edu	37	1	186056718	186056718	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:186056718G>T	uc001grq.1	+	60	9533	c.9304G>T	c.(9304-9306)GAG>TAG	p.E3102*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3102	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATGATAACAGAGTCTACTCA	0.428			NA											17	91					2.35188e-11	3.37103e-11	0.006122	1	0
OR2M5	127059	broad.mit.edu	37	1	248308722	248308722	+	Silent	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:248308722C>G	uc010pze.1	+	1	273	c.273C>G	c.(271-273)TCC>TCG	p.S91S		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GCAGCAAGTCCATTTCTATGG	0.463			NA											145	317					0	0	0.01441	0	0
PTCHD3	374308	broad.mit.edu	37	10	27688056	27688056	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:27688056T>A	uc001itu.2	-	4	1589	c.1471A>T	c.(1471-1473)ACA>TCA	p.T491S		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	491	SSD.|Helical; (Potential).				spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTGGTGATTGTAATAGACACT	0.413			NA											13	32					0	0	0.001855	0	0
ERCC6	2074	broad.mit.edu	37	10	50667157	50667157	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:50667157T>C	uc001jhs.3	-	21	4340	c.4186A>G	c.(4186-4188)AGA>GGA	p.R1396G	ERCC6_uc009xod.2_Missense_Mutation_p.R556G|ERCC6_uc010qgr.1_Missense_Mutation_p.R766G|ERCC6_uc001jhr.3_Missense_Mutation_p.R764G	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1396					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						AGGTGGTTTCTAGCTCTCATT	0.512			NA						Direct_reversal_of_damage|NER					18	76					0	0	0.00499	0	0
GRID1	2894	broad.mit.edu	37	10	87373269	87373269	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:87373269G>A	uc001kdl.1	-	15	2597	c.2496C>T	c.(2494-2496)GCC>GCT	p.A832A	GRID1_uc009xsu.1_RNA|GRID1_uc010qmf.1_Silent_p.A403A	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	832	Helical; (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGAAGACCCCGGCGAAGCTGT	0.657			NA								Multiple Myeloma(13;0.14)			4	60					0	0	0.009096	0	0
EIF4G2	1982	broad.mit.edu	37	11	10822541	10822541	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:10822541G>C	uc001mjc.2	-	15	1924	c.1507C>G	c.(1507-1509)CCA>GCA	p.P503A	EIF4G2_uc001mjb.2_Missense_Mutation_p.P297A|EIF4G2_uc009ygf.2_Missense_Mutation_p.P297A|EIF4G2_uc001mjd.2_Missense_Mutation_p.P465A|EIF4G2_uc001mjf.1_Missense_Mutation_p.P259A	NM_001418	NP_001409	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4	503					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			ovary(1)|central_nervous_system(1)	2				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTGCGTGGTGGTTGTGCACTA	0.428			NA											4	49					0	0	0.000602	0	0
OR4S2	219431	broad.mit.edu	37	11	55418704	55418704	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:55418704G>T	uc001nhs.1	+	1	325	c.325G>T	c.(325-327)GAG>TAG	p.E109*		NM_001004059	NP_001004059	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.0748)				TGGTTGCACTGAGATCTTCAT	0.418			NA											20	111					2.37509e-13	3.52169e-13	0.010504	1	0
OR5L1	219437	broad.mit.edu	37	11	55579820	55579820	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:55579820G>T	uc001nhw.1	+	1	878	c.878G>T	c.(877-879)AGA>ATA	p.R293I		NM_001004738	NP_001004738	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L,	293	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|ovary(2)	5		all_epithelial(135;0.208)				TACAGCCTGAGAAATAAAGAT	0.453			NA											4	38					0.000602214	0.000690539	0.000602	1	0
OTUB1	55611	broad.mit.edu	37	11	63764060	63764060	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:63764060A>G	uc001nyf.1	+	4	882	c.278A>G	c.(277-279)TAT>TGT	p.Y93C	OTUB1_uc001nyg.1_Missense_Mutation_p.I67V|OTUB1_uc010rmz.1_Missense_Mutation_p.Y130C|OTUB1_uc010rna.1_Missense_Mutation_p.I33V|OTUB1_uc009ypa.2_Intron|OTUB1_uc009ypb.1_Missense_Mutation_p.Y63C	NM_017670	NP_060140	Q96FW1	OTUB1_HUMAN	otubain 1	93	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)	1						AACTGTTTCTATCGGGCTTTC	0.592			NA											29	32					0	0	0.005443	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64596984	64596984	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:64596984C>A	uc001obs.3	-	30	3926	c.3926G>T	c.(3925-3927)CGT>CTT	p.R1309L		NM_017525	NP_059995	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1309	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(3)|central_nervous_system(1)	4						CTCGTGGCCACGAGACTTGCG	0.652			NA											14	26					0.00244969	0.00270095	0.00245	1	0
SLC36A4	120103	broad.mit.edu	37	11	92881884	92881884	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:92881884T>C	uc001pdn.2	-	11	1431	c.1334A>G	c.(1333-1335)TAT>TGT	p.Y445C	uc001pdl.1_5'Flank|SLC36A4_uc001pdm.2_Missense_Mutation_p.Y310C	NM_152313	NP_689526	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid	445					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCATATATTATAATGTTCCTT	0.358			NA											13	25					0	0	0.003163	0	0
TROAP	10024	broad.mit.edu	37	12	49724607	49724607	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr12:49724607C>T	uc001rtx.3	+	13	2146	c.1979C>T	c.(1978-1980)CCC>CTC	p.P660L	TROAP_uc009zlh.2_Missense_Mutation_p.P660L|TROAP_uc001rty.2_Missense_Mutation_p.P339L	NM_005480	NP_005471	Q12815	TROAP_HUMAN	tastin isoform 1	660	Cys-rich.				cell adhesion	cytoplasm				ovary(1)	1						AGTCTACCACCCTGCTGCAGT	0.607			NA											21	127					0	0	0.012319	0	0
FBXO21	23014	broad.mit.edu	37	12	117612494	117612494	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr12:117612494C>T	uc001twk.2	-	5	740	c.701G>A	c.(700-702)GGC>GAC	p.G234D	FBXO21_uc001twj.2_Missense_Mutation_p.G234D|FBXO21_uc009zwq.2_Missense_Mutation_p.G234D	NM_033624	NP_296373	O94952	FBX21_HUMAN	F-box only protein 21 isoform 1	234					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	ubiquitin-protein ligase activity			kidney(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0291)		ACTGTTTATGCCCCGAAGGGT	0.468	GBM(168;452 2038 13535 17701 43680)		NA											3	41					0	0	0.004672	0	0
B3GNT4	79369	broad.mit.edu	37	12	122691766	122691766	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr12:122691766C>T	uc001ubx.2	+	3	1186	c.968C>T	c.(967-969)GCT>GTT	p.A323V	B3GNT4_uc001uby.2_Missense_Mutation_p.A298V	NM_030765	NP_110392	Q9C0J1	B3GN4_HUMAN	UDP-GlcNAc:betaGal	323	Lumenal (Potential).				protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			ovary(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000297)|Epithelial(86;0.000497)|BRCA - Breast invasive adenocarcinoma(302;0.222)		ATGCACCATGCTGGCTTCAAG	0.597			NA											3	50					0	0	0.004672	0	0
FLRT2	23768	broad.mit.edu	37	14	86089656	86089656	+	Silent	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr14:86089656C>T	uc001xvr.2	+	2	2565	c.1798C>T	c.(1798-1800)CTG>TTG	p.L600L	FLRT2_uc010atd.2_Silent_p.L600L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	600	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CAACTCCATCCTGGAGATGAC	0.498			NA											4	149					0	0	0.009096	0	0
GP2	2813	broad.mit.edu	37	16	20335360	20335360	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr16:20335360C>T	uc002dgv.2	-	3	396	c.313G>A	c.(313-315)GAG>AAG	p.E105K	GP2_uc002dgw.2_Missense_Mutation_p.E105K|GP2_uc002dgx.2_Intron|GP2_uc002dgy.2_Intron	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	105						anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						ACACAGGTCTCCGACATCCTT	0.592			NA											39	69					0	0	0.00874	0	0
TP53	7157	broad.mit.edu	37	17	7578526	7578526	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:7578526C>A	uc002gim.2	-	5	598	c.404G>T	c.(403-405)TGC>TTC	p.C135F	TP53_uc002gig.1_Missense_Mutation_p.C135F|TP53_uc002gih.2_Missense_Mutation_p.C135F|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.C3F|TP53_uc010cng.1_Missense_Mutation_p.C3F|TP53_uc002gii.1_Missense_Mutation_p.C3F|TP53_uc010cnh.1_Missense_Mutation_p.C135F|TP53_uc010cni.1_Missense_Mutation_p.C135F|TP53_uc002gij.2_Missense_Mutation_p.C135F|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.C42F|TP53_uc002gio.2_Missense_Mutation_p.C3F|TP53_uc010vug.1_Missense_Mutation_p.C96F	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	135	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		C -> S (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> R (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(51)|p.C135F(34)|p.C135W(19)|p.C135S(10)|p.C135fs*35(9)|p.0?(7)|p.C135*(7)|p.C135G(6)|p.C135R(6)|p.C135C(5)|p.C135fs*14(2)|p.N131fs*27(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*36(1)|p.C135fs*15(1)|p.Y126fs*11(1)|p.C135_A138delCQLA(1)|p.C42Y(1)|p.C3Y(1)|p.M133fs*13(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)|p.C135_Q136insXXXXXX(1)|p.C135_Q136insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCAGTTGGCAAAACATCTT	0.572	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	28					7.48243e-07	9.06322e-07	0.006214	1	0
NCOR1	9611	broad.mit.edu	37	17	16024509	16024509	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:16024509C>A	uc002gpo.2	-	16	1949	c.1709G>T	c.(1708-1710)CGG>CTG	p.R570L	NCOR1_uc002gpn.2_Missense_Mutation_p.R570L|NCOR1_uc002gpp.1_Missense_Mutation_p.R461L|NCOR1_uc002gpr.2_Missense_Mutation_p.R461L	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	570					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTTCGCCCCCGGGGTGTGGC	0.537			NA											32	84					9.65963e-10	1.31862e-09	0.003271	1	0
PLD6	201164	broad.mit.edu	37	17	17106252	17106252	+	Silent	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:17106252C>A	uc002gqz.2	-	2	620	c.588G>T	c.(586-588)CGG>CGT	p.R196R	PLD6_uc010cpn.2_RNA	NM_178836	NP_849158	Q8N2A8	PLD6_HUMAN	phospholipase D6	196	Cytoplasmic (Potential).				DNA methylation involved in gamete generation|lipid catabolic process|meiosis|mitochondrial fusion|P granule organization|piRNA metabolic process|spermatid development	integral to membrane|mitochondrial outer membrane	cardiolipin hydrolase activity|protein homodimerization activity				0						CCAGAAAAAGCCGCACGTACT	0.507			NA											21	43					3.62473e-10	5.02785e-10	0.012319	1	0
NUP85	79902	broad.mit.edu	37	17	73206052	73206052	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:73206052G>T	uc002jng.1	+	3	522	c.262G>T	c.(262-264)GAG>TAG	p.E88*	NUP85_uc010dgd.1_Nonsense_Mutation_p.E88*|NUP85_uc010wrv.1_Nonsense_Mutation_p.E42*	NM_024844	NP_079120	Q9BW27	NUP85_HUMAN	nucleoporin 85	88					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			ovary(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			AATTGACGAAGAGTTGACTGG	0.403			NA											14	49					1.67942e-08	2.18833e-08	0.006122	1	0
CCDC57	284001	broad.mit.edu	37	17	80146200	80146200	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:80146200C>T	uc002kdz.1	-	8	1302	c.947G>A	c.(946-948)AGG>AAG	p.R316K	CCDC57_uc002kdx.1_Missense_Mutation_p.R316K	NM_198082	NP_932348	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	316	Potential.									ovary(2)	2	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CTCCAGAACCCTGGTCTGCAG	0.652			NA											4	12					0	0	0.009096	0	0
KLHL14	57565	broad.mit.edu	37	18	30254700	30254700	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr18:30254700C>T	uc002kxm.1	-	9	2195	c.1807G>A	c.(1807-1809)GAA>AAA	p.E603K	KLHL14_uc010dmd.1_Missense_Mutation_p.E152K	NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	603	Kelch 6.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						ACATCTCCTTCGAGTTCTGTC	0.473			NA											5	164					0	0	0.000602	0	0
PRR12	57479	broad.mit.edu	37	19	50099261	50099261	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr19:50099261G>T	uc002poo.3	+	4	1669	c.1669G>T	c.(1669-1671)GGT>TGT	p.G557C		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	330	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGAGGCGGCGGTGAGGCCAG	0.692			NA											11	42					1.08611e-07	1.3537e-07	0.010729	1	0
BIRC8	112401	broad.mit.edu	37	19	53793270	53793270	+	Missense_Mutation	SNP	G	G	C	rs113838023	byFrequency	TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr19:53793270G>C	uc002qbk.2	-	1	1606	c.358C>G	c.(358-360)CGA>GGA	p.R120G		NM_033341	NP_203127	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat-containing 8	120					apoptosis		zinc ion binding	p.R120*(1)		lung(1)	1				GBM - Glioblastoma multiforme(134;0.00304)		AATCCCATTCGTATAGCTTCT	0.383			NA											16	81					0	0	0.003163	0	0
KIDINS220	57498	broad.mit.edu	37	2	8919861	8919861	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr2:8919861G>A	uc002qzc.2	-	18	2495	c.2313C>T	c.(2311-2313)GTC>GTT	p.V771V	KIDINS220_uc010yiv.1_Silent_p.V537V|KIDINS220_uc002qzd.2_Silent_p.V729V|KIDINS220_uc010yiw.1_Silent_p.V772V	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	771	KAP NTPase.|Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CATCGATGATGACCACCAGCC	0.463			NA											11	33					0	0	0.010729	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170309	207170309	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr2:207170309T>C	uc002vbp.2	+	5	1307	c.1057T>C	c.(1057-1059)TTT>CTT	p.F353L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	353							nucleic acid binding|zinc ion binding			ovary(3)	3						CAAGACAGCCTTTTGGGAACA	0.388			NA											11	39					0	0	0.013537	0	0
KIAA0406	9675	broad.mit.edu	37	20	36641109	36641109	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr20:36641109G>A	uc002xhl.2	-	3	1319	c.1110C>T	c.(1108-1110)CTC>CTT	p.L370L	KIAA0406_uc002xhm.2_Silent_p.L370L	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	370							binding				0		Myeloproliferative disorder(115;0.00874)				AGATGTCAGCGAGGGCTTTGT	0.458			NA											15	136					0	0	0.010504	0	0
PTGIS	5740	broad.mit.edu	37	20	48140776	48140776	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr20:48140776C>A	uc002xut.2	-	6	728	c.674G>T	c.(673-675)GGG>GTG	p.G225V	PTGIS_uc010zyi.1_Missense_Mutation_p.G86V	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	225					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	GTCCTTGTCCCCTGCAGGGAC	0.602			NA											4	72					0.00909568	0.00990163	0.009096	1	0
CADPS	8618	broad.mit.edu	37	3	62751619	62751619	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr3:62751619T>C	uc003dll.2	-	2	842	c.482A>G	c.(481-483)CAG>CGG	p.Q161R	CADPS_uc003dlm.2_Missense_Mutation_p.Q161R|CADPS_uc003dln.2_Missense_Mutation_p.Q161R	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	161					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GAGGAAAGCCTGAAACCGGTC	0.463			NA											3	68					0	0	0.004672	0	0
ZNF148	7707	broad.mit.edu	37	3	124951371	124951371	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr3:124951371G>C	uc003ehx.3	-	9	2685	c.2199C>G	c.(2197-2199)TTC>TTG	p.F733L	SLC12A8_uc003ehw.3_Intron|ZNF148_uc003ehz.3_Missense_Mutation_p.F733L|ZNF148_uc010hsa.2_Missense_Mutation_p.F733L|ZNF148_uc003eia.3_Missense_Mutation_p.F733L|ZNF148_uc003ehy.2_Missense_Mutation_p.F70L	NM_021964	NP_068799	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	733					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4						AGGGAGCACGGAAGGGCTGTT	0.493			NA											22	61					0	0	0.010504	0	0
TNK2	10188	broad.mit.edu	37	3	195593860	195593860	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr3:195593860G>A	uc003fvu.1	-	14	3553	c.3010C>T	c.(3010-3012)CGG>TGG	p.R1004W	TNK2_uc003fvq.1_Missense_Mutation_p.R413W|TNK2_uc003fvr.1_Missense_Mutation_p.R531W|TNK2_uc003fvs.1_Missense_Mutation_p.R1006W|TNK2_uc003fvt.1_Missense_Mutation_p.R1052W	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	1004				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CCTCTGGGCCGCAGACCCAGC	0.682			NA											3	30					0	0	0.004672	0	0
SCFD2	152579	broad.mit.edu	37	4	53786890	53786890	+	Splice_Site	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:53786890G>A	uc003gzu.2	-	6	1841	c.1707_splice	c.e6+1	p.Q569_splice	SCFD2_uc010igm.2_Splice_Site_p.Q569_splice	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2						protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GTATATACTTGCCTGGTGGGT	0.373			NA											6	46					0	0	0.001168	0	0
TECRL	253017	broad.mit.edu	37	4	65274985	65274985	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:65274985C>A	uc003hcv.2	-	1	194	c.85G>T	c.(85-87)GAT>TAT	p.D29Y	TECRL_uc003hcw.2_Missense_Mutation_p.D29Y	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	29					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						TTTCTCATATCATCCTTCAGT	0.428			NA											13	54					3.27435e-08	4.2029e-08	0.00245	1	0
KIAA1109	84162	broad.mit.edu	37	4	123192658	123192658	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:123192658G>A	uc003ieh.2	+	45	8024	c.7979G>A	c.(7978-7980)AGA>AAA	p.R2660K	KIAA1109_uc003iel.1_Missense_Mutation_p.R595K|KIAA1109_uc003iek.2_Missense_Mutation_p.R1279K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2660					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCATTAGGAAGATCTGAAAGA	0.353			NA											4	20					0	0	0.009096	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192663	123192663	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:123192663G>A	uc003ieh.2	+	45	8029	c.7984G>A	c.(7984-7986)GAA>AAA	p.E2662K	KIAA1109_uc003iel.1_Missense_Mutation_p.E597K|KIAA1109_uc003iek.2_Missense_Mutation_p.E1281K	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2662					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						AGGAAGATCTGAAAGAAGAAC	0.348			NA											3	19					0	0	0.004672	0	0
CEP72	55722	broad.mit.edu	37	5	639251	639251	+	Silent	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:639251G>T	uc003jbf.2	+	8	1326	c.1254G>T	c.(1252-1254)CTG>CTT	p.L418L	CEP72_uc011clz.1_RNA	NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	418					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			AGACGGCCCTGCAGGCGGCGC	0.632			NA											19	53					1.67942e-08	2.18833e-08	0.006122	1	0
ITGA1	3672	broad.mit.edu	37	5	52235460	52235460	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:52235460G>A	uc003jou.2	+	25	3171	c.3119G>A	c.(3118-3120)AGT>AAT	p.S1040N	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Missense_Mutation_p.S571N	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	1040	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GATCCTTTCAGTATCAACTCT	0.358			NA											5	20					0	0	0.001168	0	0
CDHR2	54825	broad.mit.edu	37	5	176019778	176019778	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:176019778C>G	uc003mem.1	+	31	3855	c.3789C>G	c.(3787-3789)ATC>ATG	p.I1263M	CDHR2_uc003men.1_Missense_Mutation_p.I1263M	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	1263	Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GTCAGGAAATCAAGGCAAGAT	0.552			NA											23	53					0	0	0.00632	0	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:29910607G>C	uc003nol.2	+	2	147	c.147G>C	c.(145-147)GTG>GTC	p.V49V	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Silent_p.V49V|HLA-A_uc003noo.2_Silent_p.V49V|HLA-A_uc010jrr.2_Silent_p.V49V|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Silent_p.V21V|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						TCATCGCCGTGGGCTACGTGG	0.692			NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			7	32					0	0	0.004482	0	0
DNAH8	1769	broad.mit.edu	37	6	38843499	38843499	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:38843499G>A	uc003ooe.1	+	51	7702	c.7102G>A	c.(7102-7104)GAA>AAA	p.E2368K		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AGAAAGCAGAGAAAAGCTTGA	0.398			NA											4	43					0	0	0.001168	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130425623	130425623	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:130425623C>A	uc003qbt.2	+	19	1959	c.1789C>A	c.(1789-1791)CCA>ACA	p.P597T	L3MBTL3_uc003qbu.2_Missense_Mutation_p.P572T	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	597					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CCGTATTTTTCCAGACCGCTT	0.378			NA											35	48					2.66277e-13	3.88132e-13	0.006999	1	0
FTSJ2	29960	broad.mit.edu	37	7	2279318	2279318	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:2279318G>A	uc003slm.2	-	2	62	c.33C>T	c.(31-33)TCC>TCT	p.S11S	FTSJ2_uc003slk.2_Intron|FTSJ2_uc003sll.2_5'UTR|FTSJ2_uc003sln.2_RNA|FTSJ2_uc003slo.2_Intron|NUDT1_uc003slp.1_5'Flank|NUDT1_uc003slq.1_5'Flank|NUDT1_uc003slr.1_5'Flank|NUDT1_uc003sls.1_5'Flank|NUDT1_uc003slt.1_5'Flank	NM_013393	NP_037525	Q9UI43	RRMJ2_HUMAN	FtsJ homolog 2	11					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			ovary(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		GACGCTGAAAGGAAACACACA	0.453			NA											13	86					0	0	0.006122	0	0
SNX8	29886	broad.mit.edu	37	7	2309240	2309240	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:2309240C>A	uc003slw.2	-	5	618	c.575G>T	c.(574-576)TGC>TTC	p.C192F		NM_013321	NP_037453	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	192					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			large_intestine(1)|ovary(1)	2		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		GTCCCCGACGCACTGTGCTGA	0.378			NA											7	28					1.26484e-09	1.69964e-09	0.00308	1	0
PKD1L1	168507	broad.mit.edu	37	7	47882684	47882684	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:47882684A>G	uc003tny.1	-	34	5321	c.5321T>C	c.(5320-5322)GTA>GCA	p.V1774A		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1774	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ATGATGATCTACTTGTCTACT	0.413			NA											6	23					0	0	0.001984	0	0
EGFR	1956	broad.mit.edu	37	7	55242490	55242490	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:55242490A>G	uc003tqk.2	+	19	2506	c.2260A>G	c.(2260-2262)AAA>GAA	p.K754E	EGFR_uc010kzg.1_Missense_Mutation_p.K709E|EGFR_uc011kco.1_Missense_Mutation_p.K701E	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	754	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S752_I759del(15)|p.T751_I759>N(8)|p.T751_I759>S(3)|p.A750_E758>P(3)|p.A750_K757del(2)|p.A750_E758del(2)|p.T751_I759>NKA(2)|p.E749_E758>QP(2)|p.T751_E758del(2)|p.K754E(2)|p.L747_K754>ST(1)|p.L747_N756>SKDD(1)|p.T751_E758>A(1)|p.T751_I759>REA(1)|p.L747_A755del(1)|p.P753_I759del(1)|p.K754R(1)|p.K754K(1)|p.K754A(1)|p.L747_A755>SKS(1)|p.L747_K754>N(1)|p.A750_K754del(1)|p.L747_K754del(1)|p.L747_K754>GC(1)|p.S752_V769del(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AACATCTCCGAAAGCCAACAA	0.493			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			9	34					0	0	0.006214	0	0
CUL1	8454	broad.mit.edu	37	7	148497609	148497609	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:148497609C>G	uc010lpg.2	+	22	2792	c.2266C>G	c.(2266-2268)CTA>GTA	p.L756V	CUL1_uc003wey.2_Missense_Mutation_p.L756V|CUL1_uc003wez.2_Missense_Mutation_p.L646V|CUL1_uc003wfa.2_Missense_Mutation_p.L417V	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	756					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CATTGACATTCTAATTGAGAA	0.428			NA											9	32					0	0	0.004482	0	0
DNAJB6	10049	broad.mit.edu	37	7	157174955	157174955	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:157174955A>T	uc003wnk.2	+	6	516	c.362A>T	c.(361-363)GAC>GTC	p.D121V	DNAJB6_uc003wnj.2_Missense_Mutation_p.D121V|DNAJB6_uc003wnl.2_Missense_Mutation_p.D108V|DNAJB6_uc011kvy.1_Missense_Mutation_p.D72V|DNAJB6_uc011kvz.1_Intron|DNAJB6_uc010lqt.2_Missense_Mutation_p.D121V	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	121	Gly/Phe-rich.|Interaction with HSP70.|Interaction with KRT18.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CCTTTTGAGGACTTCTTTGGG	0.418	Esophageal Squamous(46;195 967 1350 20350 43814)		NA											11	39					0	0	0.008291	0	0
LETM2	137994	broad.mit.edu	37	8	38250462	38250462	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr8:38250462G>T	uc003xlm.1	+	3	480	c.309G>T	c.(307-309)ATG>ATT	p.M103I	LETM2_uc003xlk.2_Missense_Mutation_p.M150I|LETM2_uc011lbn.1_5'UTR|LETM2_uc003xll.1_Missense_Mutation_p.M103I|LETM2_uc003xln.1_5'UTR|LETM2_uc003xlo.1_5'UTR	NM_144652	NP_653253	Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane	150	LETM1.|Mitochondrial intermembrane (Potential).					integral to membrane|mitochondrial inner membrane					0	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			CTGCCAGAATGGTTTGGAGGC	0.373			NA											9	15					1.11149e-13	1.70693e-13	0.008291	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617547	77617548	+	Missense_Mutation	DNP	GG	GG	CT	rs13250763		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr8:77617547_77617548GG>CT	uc003yav.2	+	2	1611_1612	c.1224_1225GG>CT	c.(1222-1227)CTGGGG>CTCTGG	p.G409W	ZFHX4_uc003yat.1_Missense_Mutation_p.G409W|ZFHX4_uc003yau.1_Missense_Mutation_p.G409W|ZFHX4_uc003yaw.1_Missense_Mutation_p.G409W	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	409						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAGTGAATCTGGGGGGGCTGTC	0.535			NA								HNSCC(33;0.089)			7	16					0	0	0.004672	0	0
FAM75C1	441452	broad.mit.edu	37	9	90538360	90538360	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:90538360C>G	uc010mqi.2	+	4	3567	c.3538C>G	c.(3538-3540)CCC>GCC	p.P1180A	FAM75C1_uc004apq.3_Missense_Mutation_p.P1163A	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GCCGAAGACACCCAGTGCCTC	0.542			NA											3	69					0	0	0.009096	0	0
LAMC3	10319	broad.mit.edu	37	9	133936562	133936562	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:133936562C>T	uc004caa.1	+	13	2397	c.2299C>T	c.(2299-2301)CCA>TCA	p.P767S		NM_006059	NP_006050	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3 precursor	767	Laminin EGF-like 7.				cell adhesion	basement membrane|membrane	structural molecule activity			ovary(2)|pancreas(1)	3	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TACGACCATCCCAGAGAGCCG	0.677			NA											12	18					0	0	0.010729	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553884	135553884	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:135553884C>T	uc010mzv.2	+	2	1136	c.878C>T	c.(877-879)CCG>CTG	p.P293L	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	293					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TTTCAGCTGCCGTTTGTAGGA	0.473	Pancreas(142;417 1875 11086 31973 47667)		NA											6	50					0	0	0.001168	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139301868	139301868	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:139301868C>A	uc004chi.2	-	5	753	c.548G>T	c.(547-549)GGA>GTA	p.G183V	SDCCAG3_uc004chj.2_Missense_Mutation_p.G160V|SDCCAG3_uc004chk.2_Missense_Mutation_p.G110V	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	183						cytoplasm					0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CCCACTCCATCCGGTGTCCTC	0.622			NA											5	20					1.23904e-05	1.47996e-05	0.000602	1	0
MTMR8	55613	broad.mit.edu	37	X	63444984	63444984	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:63444984C>A	uc011mou.1	-	10	1740	c.1672G>T	c.(1672-1674)GGC>TGC	p.G558C	ASB12_uc004dvp.1_Missense_Mutation_p.G174C|ASB12_uc004dvq.1_Missense_Mutation_p.G183C|ASB12_uc004dvr.1_Missense_Mutation_p.G183C	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	Error:Variant_position_missing_in_Q96EF0_after_alignment						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						TAGAGGGGGCCAGAACATGAA	0.562			NA											6	18					0.00198382	0.00221569	0.001984	1	0
DLG3	1741	broad.mit.edu	37	X	69719800	69719800	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:69719800G>A	uc004dyi.1	+	16	2374	c.2046G>A	c.(2044-2046)ATG>ATA	p.M682I	DLG3_uc004dyj.1_Missense_Mutation_p.M377I|DLG3_uc011mpn.1_Missense_Mutation_p.M230I	NM_021120	NP_066943	Q92796	DLG3_HUMAN	synapse-associated protein 102 isoform a	682	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			large_intestine(1)|pancreas(1)	2	Renal(35;0.156)					GAGAACAAATGGAGAAAGATA	0.488			NA											5	26					0	0	0.000602	0	0
AFF2	2334	broad.mit.edu	37	X	148055037	148055037	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:148055037G>T	uc004fcp.2	+	16	3783	c.3304G>T	c.(3304-3306)GCC>TCC	p.A1102S	AFF2_uc004fcq.2_Missense_Mutation_p.A1092S|AFF2_uc004fcr.2_Missense_Mutation_p.A1063S|AFF2_uc011mxb.1_Missense_Mutation_p.A1067S|AFF2_uc004fcs.2_Missense_Mutation_p.A1067S|AFF2_uc011mxc.1_Missense_Mutation_p.A743S	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1102					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					TTATGCTGATGCCGCCCTCTC	0.453			NA											20	48					2.37509e-13	3.52169e-13	0.010504	1	0
ELF3	1999	broad.mit.edu	37	1	201983060	201983060	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:201983060delC	uc001gxg.3	+	7	4101	c.909delC	c.(907-909)TTCfs	p.F303fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.F303fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.F303fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	303	ETS.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						AAGGCGTCTTCAAGTTCCTGC	0.582			NA											11	20	---	---	---	---	NA	NA	NA	NA	NA
OBSCN	84033	broad.mit.edu	37	1	228560034	228560034	+	Frame_Shift_Del	DEL	C	C	-	rs36119328	by1000genomes	TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:228560034delC	uc009xez.1	+	94	21599	c.21555delC	c.(21553-21555)TACfs	p.Y7185fs	OBSCN_uc001hsr.1_Frame_Shift_Del_p.Y1814fs	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	7185					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GCGGGGGCTACGCAGGCGTGG	0.667			NA											5	4	---	---	---	---	NA	NA	NA	NA	NA
DUXA	503835	broad.mit.edu	37	19	57666695	57666695	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr19:57666695delT	uc002qoa.1	-	5	529	c.484delA	c.(484-486)AGGfs	p.R162fs		NM_001012729	NP_001012747	A6NLW8	DUXA_HUMAN	double homeobox A	162						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		ACAGGTTCCCTTTTTCTCTGG	0.408			NA											7	54	---	---	---	---	NA	NA	NA	NA	NA
TADA2B	93624	broad.mit.edu	37	4	7056195	7056196	+	Frame_Shift_Ins	INS	-	-	C	rs75397160		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:7056195_7056196insC	uc003gjw.3	+	2	828_829	c.677_678insC	c.(676-678)TACfs	p.Y226fs	TADA2B_uc010idi.2_Frame_Shift_Ins_p.Y151fs	NM_152293	NP_689506	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2 (ADA2 homolog,	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding				0						GCCCGTGACTACAATCTGGTGC	0.579			NA											31	105	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55242466	55242474	+	In_Frame_Del	DEL	GAATTAAGA	GAATTAAGA	-	rs121913426		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08	GAATTAAGA	GAATTAAGA	-	-	GAATTAAGA	GAATTAAGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:55242466_55242474delGAATTAAGA	uc003tqk.2	+	19	2482_2490	c.2236_2244delGAATTAAGA	c.(2236-2244)GAATTAAGAdel	p.ELR746del	EGFR_uc010kzg.1_In_Frame_Del_p.ELR701del|EGFR_uc011kco.1_In_Frame_Del_p.ELR693del	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	746_748	Cytoplasmic (Potential).|Protein kinase.		R -> P (found in a lung cancer sample).|Missing (found in a lung cancer sample).|Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1613)|p.L747_P753>S(110)|p.L747_A750>P(74)|p.E746_S752>V(67)|p.L747_T751del(62)|p.E746_T751>A(30)|p.L747_S752del(28)|p.L747_T751>P(20)|p.E746_T751del(18)|p.L747_E749del(18)|p.K745_E749del(14)|p.E746_E749del(12)|p.E746_S752del(10)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.E746_P753>VS(6)|p.E746_A750>IP(5)|p.L747_T751>Q(5)|p.E746_T751>I(5)|p.E746_T751>V(5)|p.E746_S752>A(5)|p.E746_T751>IP(5)|p.E746_A750>QP(4)|p.E746V(4)|p.E746_S752>D(4)|p.K745_A750del(4)|p.L747S(3)|p.L747_S752>Q(3)|p.E746_T751>VA(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.E746_A750>S(2)|p.E746_S752>T(2)|p.E746_T751>Q(2)|p.E746_T751>S(2)|p.E746_A750>DP(2)|p.E746_T751>L(2)|p.E746K(2)|p.E746_P753del(2)|p.E746_S752>I(2)|p.K745_E746insVPVAIK(2)|p.E746_A750>AP(2)|p.L747_K754>ST(1)|p.E746_A750>A(1)|p.E746_T751>P(1)|p.E746del(1)|p.L747_S752>QH(1)|p.L747P(1)|p.E746_A750>VP(1)|p.L747_K754>N(1)|p.L747_R748>FP(1)|p.K745_L747del(1)|p.L747_T751>A(1)|p.E746_P753>LS(1)|p.E746_P753>VQ(1)|p.E746_T751>LS(1)|p.E746_R748del(1)|p.I744_A750>VK(1)|p.E746I(1)|p.L747_K754del(1)|p.R748I(1)|p.E746_A750>KP(1)|p.E746_A750>EP(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCTATCAAGGAATTAAGAGAAGCAACAT	0.478		E746_A750del(NCIH1650_LUNG)|E746K(HCC827_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	50	---	---	---	---	NA	NA	NA	NA	NA