Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CASZ1	54897	broad.mit.edu	37	1	10702967	10702967	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:10702967T>A	uc001aro.2	-	20	4431	c.4111A>T	c.(4111-4113)ATG>TTG	p.M1371L		NM_001079843	NP_001073312	Q86V15	CASZ1_HUMAN	castor homolog 1, zinc finger isoform a	1371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			skin(1)	1	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		CTCCGGTCCATGGTGGATGAC	0.662			NA											11	17					0	0	0.080935	0	0
C1orf175	374977	broad.mit.edu	37	1	55161113	55161113	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:55161113G>C	uc010ooe.1	+	17	3238	c.2914G>C	c.(2914-2916)GAG>CAG	p.E972Q	C1orf175_uc001cxq.2_RNA|C1orf175_uc010ooc.1_Intron|C1orf175_uc001cxs.2_RNA|C1orf175_uc010ood.1_Missense_Mutation_p.E490Q|C1orf175_uc010oof.1_RNA|C1orf175_uc001cxr.1_RNA|C1orf175_uc010oog.1_Missense_Mutation_p.E972Q|C1orf175_uc010ooh.1_RNA|C1orf175_uc009vzq.1_RNA|C1orf175_uc001cxt.1_RNA|C1orf175_uc009vzr.1_Missense_Mutation_p.E174Q|C1orf175_uc001cxu.2_Missense_Mutation_p.E118Q	NM_001039464	NP_001034553	Q68CQ1	HEAT8_HUMAN	hypothetical protein LOC374977	972	HEAT 1.					integral to membrane	binding				0						CCCGCTCCTGGAGCGAGGCGA	0.667			NA											9	19					0	0	0.069234	0	0
MYSM1	114803	broad.mit.edu	37	1	59165712	59165712	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:59165712C>G	uc009wab.1	-	1	36	c.13G>C	c.(13-15)GAG>CAG	p.E5Q	MYSM1_uc001czd.2_Missense_Mutation_p.E5Q	NM_001085487	NP_001078956	Q5VVJ2	MYSM1_HUMAN	Myb-like, SWIRM and MPN domains 1	5					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin remodeling complex	DNA binding|histone binding|metal ion binding|metallopeptidase activity|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(1)	1	all_cancers(7;9.36e-06)					ACATCCGCCTCTTCAGCCGCC	0.692			NA											5	45					0	0	0.217242	0	0
ROR1	4919	broad.mit.edu	37	1	64516358	64516358	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:64516358G>T	uc001dbj.2	+	4	851	c.452G>T	c.(451-453)GGC>GTC	p.G151V	ROR1_uc001dbi.3_Missense_Mutation_p.G151V	NM_005012	NP_005003	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	151	Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			ovary(6)|large_intestine(3)|breast(3)|stomach(2)|lung(2)|central_nervous_system(1)|skin(1)|kidney(1)	19						ATTTCTTCAGGCCCCCCTCCC	0.398			NA											56	135					3.09758e-43	4.25117e-43	0.139131	1	0
IFI44L	10964	broad.mit.edu	37	1	79094635	79094636	+	Splice_Site	DNP	GG	GG	TT			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:79094635_79094636GG>TT	uc010oro.1	+	3	658	c.479_splice	c.e3-1	p.G160_splice	IFI44L_uc010orp.1_Splice_Site|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like							cytoplasm					0						ATTTCCTATAGGAATTAAGGAT	0.307			NA											12	29					0	0	0.115264	0	0
MCOLN3	55283	broad.mit.edu	37	1	85510827	85510827	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:85510827C>T	uc001dkp.2	-	2	310	c.217G>A	c.(217-219)GTG>ATG	p.V73M	MCOLN3_uc001dkq.2_Missense_Mutation_p.V73M|MCOLN3_uc001dkr.2_Missense_Mutation_p.V73M|MCOLN3_uc001dks.3_Translation_Start_Site	NM_018298	NP_060768	Q8TDD5	MCLN3_HUMAN	mucolipin 3	73	Helical; (Potential).					integral to membrane	ion channel activity			skin(1)	1				all cancers(265;0.00957)|Epithelial(280;0.0254)		TGGATAGTCACCATTGCAATT	0.343			NA											13	19					0	0	0.146539	0	0
IGSF3	3321	broad.mit.edu	37	1	117150638	117150638	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:117150638T>G	uc001egr.1	-	5	1853	c.1148A>C	c.(1147-1149)AAA>ACA	p.K383T	IGSF3_uc001egq.1_Missense_Mutation_p.K383T|IGSF3_uc001egs.1_Missense_Mutation_p.K56T	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	383	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGTCACGGTTTTCTCTCGCTC	0.517			NA											52	86					0	0	0.139131	0	0
ITGA10	8515	broad.mit.edu	37	1	145532169	145532169	+	Silent	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:145532169G>T	uc001eoa.2	+	8	889	c.813G>T	c.(811-813)CTG>CTT	p.L271L	NBPF10_uc001emp.3_Intron|ITGA10_uc010oyv.1_Silent_p.L140L|ITGA10_uc009wiw.2_Silent_p.L128L|ITGA10_uc010oyw.1_Silent_p.L216L	NM_003637	NP_003628	O75578	ITA10_HUMAN	integrin, alpha 10 precursor	271	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			lung(2)|ovary(2)|kidney(2)|large_intestine(1)|skin(1)	8	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCAGGCTACTGGTGGTTGTCA	0.542			NA											11	143					1.49906e-05	1.64814e-05	0.11911	1	0
FDPS	2224	broad.mit.edu	37	1	155290326	155290326	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:155290326G>A	uc001fkc.2	+	11	1405	c.1186G>A	c.(1186-1188)GAA>AAA	p.E396K	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.E330K|FDPS_uc001fke.2_Missense_Mutation_p.E396K|FDPS_uc001fkf.2_Missense_Mutation_p.E330K|C1orf104_uc001fkh.1_Intron|C1orf104_uc001fki.2_3'UTR|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank|RUSC1_uc009wqn.1_5'Flank|RUSC1_uc009wqo.1_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	396					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	GGCTCTCATTGAACAGTACGC	0.547			NA											5	96					0	0	0.184627	0	0
FCRL1	115350	broad.mit.edu	37	1	157772326	157772326	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:157772326C>A	uc001frg.2	-	4	561	c.448G>T	c.(448-450)GGG>TGG	p.G150W	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.G150W|FCRL1_uc001fri.2_Missense_Mutation_p.G150W|FCRL1_uc001frj.2_Intron	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	150	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTACAGCCCCTTTGTACCAA	0.517	GBM(54;482 1003 11223 30131 35730)		NA											63	68					9.42754e-34	1.27625e-33	0.139131	1	0
FAM78B	149297	broad.mit.edu	37	1	166135391	166135391	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:166135391G>T	uc001gdr.2	-	2	685	c.95C>A	c.(94-96)ACG>AAG	p.T32K	FAM78B_uc010plc.1_RNA	NM_001017961	NP_001017961	Q5VT40	FA78B_HUMAN	hypothetical protein LOC149297	32								p.T32T(1)		central_nervous_system(1)|skin(1)	2	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					CTCGATGCGCGTGGGGCACTG	0.647			NA											5	14					8.12818e-05	8.64978e-05	0.02938	1	0
DUSP27	92235	broad.mit.edu	37	1	167082975	167082975	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:167082975G>A	uc001geb.1	+	2	139	c.139G>A	c.(139-141)GAA>AAA	p.E47K		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	47					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						TGCAGAAACAGAAAGCATTTT	0.428			NA											18	411					0	0	0.069288	0	0
C1orf9	51430	broad.mit.edu	37	1	172554999	172554999	+	Silent	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:172554999A>T	uc001giq.3	+	17	1885	c.1569A>T	c.(1567-1569)GGA>GGT	p.G523G	C1orf9_uc010pmm.1_Silent_p.G523G|C1orf9_uc009wwd.2_Silent_p.G479G|C1orf9_uc010pmn.1_Silent_p.G486G|C1orf9_uc010pmo.1_Intron	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	523					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		TTAAAATAGGAAATAAAAGTA	0.264	Colon(43;174 953 11768 38880 47057)		NA											103	127					0	0	0.139131	0	0
RNASEL	6041	broad.mit.edu	37	1	182553258	182553258	+	Silent	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:182553258G>T	uc001gpj.1	-	2	1691	c.1524C>A	c.(1522-1524)ATC>ATA	p.I508I	RNASEL_uc009wxz.1_Silent_p.I508I|RNASEL_uc001gpk.2_Silent_p.I508I|RNASEL_uc009wya.1_Intron	NM_021133	NP_066956	Q05823	RN5A_HUMAN	ribonuclease L	508	Protein kinase.				mRNA processing|response to virus|type I interferon-mediated signaling pathway	mitochondrion	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding|protein kinase activity|RNA binding			ovary(4)|stomach(1)	5						CAGCCCACTTGATGCTCTTAT	0.383			NA							Hereditary_Prostate_Cancer				28	107					6.00712e-18	7.76245e-18	0.163468	1	0
CFHR1	3078	broad.mit.edu	37	1	196799682	196799682	+	Silent	SNP	T	T	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:196799682T>C	uc001gtn.2	+	5	774	c.660T>C	c.(658-660)ACT>ACC	p.T220T	CFHR1_uc001gtm.2_Silent_p.T124T	NM_002113	NP_002104	Q03591	FHR1_HUMAN	complement factor H-related 1 precursor	220	Sushi 4.				complement activation	extracellular space					0						GGGACATTACTTCATTCCCGT	0.398			NA											64	79					0	0	0.139131	0	0
CHI3L1	1116	broad.mit.edu	37	1	203154346	203154346	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:203154346T>A	uc001gzi.2	-	3	394	c.223A>T	c.(223-225)ACG>TCG	p.T75S	FMOD_uc010pqi.1_Intron|CHI3L1_uc001gzj.2_Missense_Mutation_p.T75S	NM_001276	NP_001267	P36222	CH3L1_HUMAN	chitinase 3-like 1 precursor	75					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			pancreas(1)	1						CCGTAGAGCGTCACATCATTC	0.577			NA											12	132					0	0	0.132662	0	0
OPTC	26254	broad.mit.edu	37	1	203472695	203472695	+	Silent	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:203472695C>A	uc001gzu.1	+	7	962	c.846C>A	c.(844-846)ACC>ACA	p.T282T		NM_014359	NP_055174	Q9UBM4	OPT_HUMAN	opticin precursor	282	LRR 5.					proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding				0			BRCA - Breast invasive adenocarcinoma(75;0.109)			TGATAGAGACCATGCAGAGAG	0.557			NA											42	66					1.6237e-14	2.01947e-14	0.131918	1	0
ANGEL2	90806	broad.mit.edu	37	1	213186478	213186478	+	Silent	SNP	G	G	A	rs138048743		TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:213186478G>A	uc001hjz.2	-	2	497	c.342C>T	c.(340-342)AAC>AAT	p.N114N	ANGEL2_uc010pto.1_Intron|ANGEL2_uc010ptp.1_Intron|ANGEL2_uc001hka.2_Intron|ANGEL2_uc010ptq.1_Intron|ANGEL2_uc001hkb.2_Silent_p.N92N	NM_144567	NP_653168	Q5VTE6	ANGE2_HUMAN	LOC90806 protein	114											0				OV - Ovarian serous cystadenocarcinoma(81;0.00446)|all cancers(67;0.0169)|Epithelial(68;0.0921)|GBM - Glioblastoma multiforme(131;0.185)		CTCCCTCAGCGTTCATGACGT	0.403			NA											31	101					0	0	0.214465	0	0
PROX1	5629	broad.mit.edu	37	1	214170908	214170908	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:214170908G>C	uc001hkh.2	+	2	1302	c.1030G>C	c.(1030-1032)GAA>CAA	p.E344Q	PROX1_uc001hkg.1_Missense_Mutation_p.E344Q	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	344					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CTTACAACCGGAAGGCAAACA	0.512			NA											20	63					0	0	0.234183	0	0
CHRM3	1131	broad.mit.edu	37	1	240070927	240070927	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:240070927C>A	uc001hyp.2	+	5	955	c.176C>A	c.(175-177)CCT>CAT	p.P59H		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	59	Extracellular (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	ACCGATGACCCTCTGGGAGGT	0.552			NA											40	26					1.76056e-25	2.3202e-25	0.124865	1	0
OR2T6	254879	broad.mit.edu	37	1	248551197	248551197	+	Silent	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:248551197C>A	uc001iei.1	+	1	288	c.288C>A	c.(286-288)GCC>GCA	p.A96A		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTCATCGCCTGCACTGCTC	0.532			NA											60	34					1.17004e-41	1.59479e-41	0.139131	1	0
CAMK1D	57118	broad.mit.edu	37	10	12833187	12833187	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:12833187G>A	uc001ilo.2	+	6	831	c.596G>A	c.(595-597)AGC>AAC	p.S199N	CAMK1D_uc001iln.2_Missense_Mutation_p.S199N	NM_153498	NP_705718	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	199	Protein kinase.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)|stomach(1)	2				GBM - Glioblastoma multiforme(1;3.16e-05)		AAACCTTACAGCAAAGCCGTT	0.473			NA											27	71					0	0	0.125774	0	0
TRDMT1	1787	broad.mit.edu	37	10	17204237	17204237	+	Splice_Site	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:17204237C>G	uc001iop.2	-	4	300	c.252_splice	c.e4-1	p.R84_splice	TRDMT1_uc001ioq.2_Intron|TRDMT1_uc001ior.2_Intron|TRDMT1_uc001ios.2_Splice_Site_p.R13_splice|TRDMT1_uc009xjt.2_Splice_Site_p.K25_splice|TRDMT1_uc010qcc.1_Splice_Site_p.R13_splice|TRDMT1_uc010qcd.1_Intron|TRDMT1_uc009xjs.1_Intron|TRDMT1_uc009xju.1_Intron	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform						tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						CCGGCCAATCCTAAAGGGGTa	0.313			NA											21	50					0	0	0.069288	0	0
IPMK	253430	broad.mit.edu	37	10	59955896	59955896	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:59955896C>T	uc001jkb.2	-	6	1515	c.1192G>A	c.(1192-1194)GGA>AGA	p.G398R		NM_152230	NP_689416	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	398						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			ovary(1)	1						TAAACATATCCCTCATCTATT	0.388			NA											20	86					0	0	0.219247	0	0
MYPN	84665	broad.mit.edu	37	10	69934049	69934049	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:69934049G>A	uc001jnm.3	+	12	2385	c.2200G>A	c.(2200-2202)GCA>ACA	p.A734T	MYPN_uc001jnn.3_Missense_Mutation_p.A459T|MYPN_uc001jno.3_Missense_Mutation_p.A734T|MYPN_uc009xpt.2_Missense_Mutation_p.A734T|MYPN_uc010qit.1_Missense_Mutation_p.A440T|MYPN_uc010qiu.1_RNA	NM_032578	NP_115967	Q86TC9	MYPN_HUMAN	myopalladin	734						nucleus|sarcomere	actin binding			ovary(3)|skin(2)	5						GAACACCACCGCAGCAACTGT	0.542			NA											8	169					0	0	0.047766	0	0
DNA2	1763	broad.mit.edu	37	10	70225496	70225496	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:70225496T>A	uc001jof.2	-	4	773	c.773A>T	c.(772-774)AAT>ATT	p.N258I	DNA2_uc001jog.1_Missense_Mutation_p.N172I|DNA2_uc001joh.1_RNA	NM_001080449	NP_001073918	P51530	DNA2L_HUMAN	DNA replication helicase 2 homolog	172					base-excision repair|DNA replication, removal of RNA primer|mitochondrial DNA repair|mitochondrial DNA replication|positive regulation of DNA replication|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	mitochondrial nucleoid|nucleoplasm	5'-flap endonuclease activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|site-specific endodeoxyribonuclease activity, specific for altered base				0						GGCAAAGCTATTATTTATGGC	0.368			NA											6	12					0	0	0.02938	0	0
PAPSS2	9060	broad.mit.edu	37	10	89475540	89475540	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:89475540A>C	uc001kex.2	+	7	1068	c.805A>C	c.(805-807)AAA>CAA	p.K269Q	PAPSS2_uc001kew.2_Missense_Mutation_p.K269Q|PAPSS2_uc009xtg.1_RNA	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	269	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CACTCCCCTCAAAGGTTTCAT	0.433			NA											21	51					0	0	0.099896	0	0
TACC2	10579	broad.mit.edu	37	10	124013514	124013514	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:124013514A>C	uc001lfv.2	+	23	9150	c.8790A>C	c.(8788-8790)GAA>GAC	p.E2930D	TACC2_uc001lfw.2_Missense_Mutation_p.E1076D|TACC2_uc009xzx.2_Missense_Mutation_p.E2808D|TACC2_uc010qtv.1_Missense_Mutation_p.E2857D|TACC2_uc001lfx.2_Missense_Mutation_p.E557D|TACC2_uc001lfy.2_Missense_Mutation_p.E553D|TACC2_uc001lfz.2_Missense_Mutation_p.E1008D|TACC2_uc001lga.2_Missense_Mutation_p.E978D|TACC2_uc009xzy.2_Missense_Mutation_p.E990D|TACC2_uc001lgb.2_Missense_Mutation_p.E888D	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2930	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGAATAAAGAAATAGAAGAAC	0.433			NA											13	44					0	0	0.11911	0	0
DMBT1	1755	broad.mit.edu	37	10	124333279	124333279	+	Splice_Site	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr10:124333279G>A	uc001lgk.1	+	6	389	c.283_splice	c.e6+1	p.G95_splice	DMBT1_uc001lgl.1_Splice_Site_p.G95_splice|DMBT1_uc001lgm.1_Splice_Site_p.G95_splice|DMBT1_uc009xzz.1_Splice_Site_p.G95_splice|DMBT1_uc010qtx.1_Splice_Site_p.G95_splice|DMBT1_uc009yaa.1_Splice_Site	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b						epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTAGCAGAAGGTAACGTCTAC	0.527	Ovarian(182;93 2026 18125 22222 38972)		NA											35	104					0	0	0.225048	0	0
MPPED2	744	broad.mit.edu	37	11	30433051	30433051	+	Silent	SNP	T	T	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:30433051T>G	uc001msr.2	-	6	969	c.849A>C	c.(847-849)CCA>CCC	p.P283P	MPPED2_uc001msq.3_Intron|MPPED2_uc009yji.2_Silent_p.P157P	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	283					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						CAAATATAATTGGAGGGTTGG	0.453			NA											23	22					0	0	0.0918	0	0
LMO2	4005	broad.mit.edu	37	11	33886309	33886309	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:33886309G>A	uc001mve.2	-	2	535	c.96C>T	c.(94-96)GGC>GGT	p.G32G	LMO2_uc001mvc.2_Silent_p.G25G|LMO2_uc001mvd.2_Silent_p.G25G|LMO2_uc010rel.1_Silent_p.G32G|LMO2_uc010rem.1_Silent_p.G101G	NM_001142316	NP_001135788	P25791	RBTN2_HUMAN	LIM domain only 2 isoform 2	32	LIM zinc-binding 1.				multicellular organismal development	nucleus	protein binding|zinc ion binding			lung(1)	1						TCTGCTGGCAGCCGCCGCATG	0.627			NA	T	TRD@	T-ALL								29	30					0	0	0.225048	0	0
OR8J3	81168	broad.mit.edu	37	11	55904276	55904276	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:55904276T>A	uc010riz.1	-	1	919	c.919A>T	c.(919-921)AAT>TAT	p.N307Y		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TAACATGGATTTTCCATGAAT	0.323			NA											4	42					0	0	0.150653	0	0
OR9G4	283189	broad.mit.edu	37	11	56510879	56510879	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:56510879G>T	uc010rjo.1	-	1	409	c.409C>A	c.(409-411)CGC>AGC	p.R137S		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GCTGCATGGCGGTCATATGCC	0.488			NA											28	102					1.36615e-20	1.77688e-20	0.173368	1	0
CYBASC3	220002	broad.mit.edu	37	11	61124140	61124140	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:61124140G>A	uc001nrf.3	-	1	222	c.46C>T	c.(46-48)CTG>TTG	p.L16L	CYBASC3_uc010rlh.1_Silent_p.L33L|CYBASC3_uc001nrg.2_Silent_p.L16L|CYBASC3_uc009ynn.2_RNA|CYBASC3_uc001nrh.2_Silent_p.L16L|CYBASC3_uc001nri.2_Intron|CYBASC3_uc009yno.2_Silent_p.L16L	NM_001161452	NP_001154924	Q8NBI2	CYAC3_HUMAN	cytochrome b, ascorbate dependent 3 isoform 2	16	Cytochrome b561.|Helical; Name=1; (Potential).				electron transport chain|transport	integral to membrane|late endosome membrane|lysosomal membrane	metal ion binding|oxidoreductase activity				0						ATAGAGCCCAGGGACCCCAGC	0.527			NA											6	79					0	0	0.047766	0	0
NXF1	10482	broad.mit.edu	37	11	62571439	62571439	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:62571439C>G	uc001nvf.1	-	2	176	c.40G>C	c.(40-42)GAA>CAA	p.E14Q	NXF1_uc001nvg.1_Missense_Mutation_p.E14Q|NXF1_uc009yog.1_Missense_Mutation_p.E57Q|NXF1_uc010rmh.1_Intron	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	14	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						TTAACGCGTTCATCATCGTGT	0.448			NA											14	69					0	0	0.175082	0	0
LRRC32	2615	broad.mit.edu	37	11	76372201	76372201	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:76372201C>A	uc001oxq.3	-	3	679	c.436G>T	c.(436-438)GGG>TGG	p.G146W	LRRC32_uc001oxr.3_Missense_Mutation_p.G146W|LRRC32_uc010rsf.1_Missense_Mutation_p.G146W	NM_005512	NP_005503	Q14392	LRC32_HUMAN	leucine rich repeat containing 32 precursor	146	Extracellular (Potential).					integral to plasma membrane					0						GGTGCCTCCCCCAGCAGCCGC	0.677			NA											12	27					6.40141e-05	6.92327e-05	0.080935	1	0
BCL9L	283149	broad.mit.edu	37	11	118772162	118772162	+	Missense_Mutation	SNP	G	G	A	rs148554205	byFrequency	TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:118772162G>A	uc001pug.2	-	6	3255	c.2290C>T	c.(2290-2292)CCC>TCC	p.P764S	BCL9L_uc009zal.2_Missense_Mutation_p.P759S	NM_182557	NP_872363	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	764	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			ovary(1)|pancreas(1)	2	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GGCCCCATGGGTGGGTCCACC	0.527			NA											4	21					0	0	0.150653	0	0
HMBS	3145	broad.mit.edu	37	11	118960770	118960770	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:118960770G>C	uc001puz.1	+	7	572	c.415G>C	c.(415-417)GAG>CAG	p.E139Q	HMBS_uc009zao.1_Missense_Mutation_p.E84Q|HMBS_uc001pvc.1_Missense_Mutation_p.E84Q|HMBS_uc009zap.1_Missense_Mutation_p.E122Q|HMBS_uc001pva.1_Missense_Mutation_p.E139Q|HMBS_uc001pvb.1_Missense_Mutation_p.E121Q|HMBS_uc001pvd.1_Missense_Mutation_p.E122Q|HMBS_uc001pve.1_Missense_Mutation_p.E122Q|HMBS_uc001pvf.1_Missense_Mutation_p.E122Q	NM_000190	NP_000181	P08397	HEM3_HUMAN	hydroxymethylbilane synthase isoform 1	139					peptidyl-pyrromethane cofactor linkage	cytosol	hydroxymethylbilane synthase activity				0	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.72e-05)		AACCCTGCCAGAGAAGAGGTA	0.542			NA							Porphyria_Acute_Intermittent				12	50					0	0	0.09319	0	0
THY1	7070	broad.mit.edu	37	11	119291006	119291006	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:119291006G>A	uc001pwq.2	-	2	162	c.128C>T	c.(127-129)ACC>ATC	p.T43I	uc001pwo.2_Intron|uc001pwp.1_Intron|THY1_uc001pwr.2_Missense_Mutation_p.T43I|THY1_uc001pws.2_RNA	NM_006288	NP_006279	P04216	THY1_HUMAN	Thy-1 cell surface antigen preproprotein	43	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity				0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		TGAACTGCTGGTATTCTCATG	0.597			NA											23	44					0	0	0.0918	0	0
OR8D2	283160	broad.mit.edu	37	11	124189609	124189609	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr11:124189609C>T	uc010sah.1	-	1	485	c.485G>A	c.(484-486)CGC>CAC	p.R162H		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		CACTGACATGCGGGTAGTATG	0.453			NA											28	37					0	0	0.134883	0	0
CACNA1C	775	broad.mit.edu	37	12	2676956	2676956	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:2676956A>T	uc009zdu.1	+	13	2204	c.1891A>T	c.(1891-1893)ACG>TCG	p.T631S	CACNA1C_uc009zdv.1_Missense_Mutation_p.T628S|CACNA1C_uc001qkb.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkc.2_Missense_Mutation_p.T631S|CACNA1C_uc001qke.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkf.2_Missense_Mutation_p.T631S|CACNA1C_uc001qjz.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkd.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkg.2_Missense_Mutation_p.T631S|CACNA1C_uc009zdw.1_Missense_Mutation_p.T631S|CACNA1C_uc001qkh.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkl.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkn.2_Missense_Mutation_p.T631S|CACNA1C_uc001qko.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkp.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkr.2_Missense_Mutation_p.T631S|CACNA1C_uc001qku.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkq.2_Missense_Mutation_p.T631S|CACNA1C_uc001qks.2_Missense_Mutation_p.T631S|CACNA1C_uc001qkt.2_Missense_Mutation_p.T631S|CACNA1C_uc001qka.1_Missense_Mutation_p.T166S|CACNA1C_uc001qki.1_Missense_Mutation_p.T367S|CACNA1C_uc001qkj.1_Missense_Mutation_p.T367S|CACNA1C_uc001qkk.1_Missense_Mutation_p.T367S|CACNA1C_uc001qkm.1_Missense_Mutation_p.T367S	NM_199460	NP_955630	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type,	631	II.|Helical; Name=S4 of repeat II; (Potential).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			ovary(10)|central_nervous_system(1)	11			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTTCAAGATCACGAGGTACTG	0.602			NA											8	11					0	0	0.038147	0	0
GPR162	27239	broad.mit.edu	37	12	6933408	6933408	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:6933408G>A	uc001qqw.1	+	2	879	c.344G>A	c.(343-345)CGC>CAC	p.R115H	GPR162_uc010sfn.1_Missense_Mutation_p.R115H|GPR162_uc001qqx.1_Intron|GPR162_uc009zfd.1_Intron|GPR162_uc001qqy.1_5'Flank	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	115	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TCCTACCATCGCATGTGGATG	0.592			NA											7	75					0	0	0.02938	0	0
USP5	8078	broad.mit.edu	37	12	6965958	6965958	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:6965958C>T	uc001qri.3	+	6	731	c.672C>T	c.(670-672)TTC>TTT	p.F224F	USP5_uc001qrh.3_Silent_p.F224F	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	224	Substrate binding.|UBP-type.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						GACGCTACTTCGATGGCAGTG	0.577			NA											6	109					0	0	0.02938	0	0
CLEC2D	29121	broad.mit.edu	37	12	9845494	9845494	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:9845494G>T	uc001qwg.1	+	4	450	c.428G>T	c.(427-429)TGG>TTG	p.W143L	CLEC2D_uc001qwf.1_Missense_Mutation_p.W143L|CLEC2D_uc009zgs.1_RNA|CLEC2D_uc001qwh.1_RNA|CLEC2D_uc009zgt.1_Intron|CLEC2D_uc009zgu.1_Intron	NM_013269	NP_037401	Q9UHP7	CLC2D_HUMAN	osteoclast inhibitory lectin isoform 1	143	Extracellular (Potential).|C-type lectin.				cell surface receptor linked signaling pathway	cell surface|endoplasmic reticulum|integral to plasma membrane|membrane fraction	sugar binding|transmembrane receptor activity				0						GGCCAACCATGGAAATGGATA	0.358			NA											14	32					5.3912e-06	6.02725e-06	0.175082	1	0
RAPGEF3	10411	broad.mit.edu	37	12	48142639	48142639	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:48142639C>T	uc009zkp.2	-	10	1431	c.991G>A	c.(991-993)GCC>ACC	p.A331T	RAPGEF3_uc010sln.1_5'Flank|RAPGEF3_uc001rpy.2_5'Flank|RAPGEF3_uc009zkq.2_Missense_Mutation_p.A331T|RAPGEF3_uc001rpz.3_Missense_Mutation_p.A373T|RAPGEF3_uc001rqa.2_5'Flank|RAPGEF3_uc009zkr.2_RNA|RAPGEF3_uc009zks.2_Missense_Mutation_p.A385T	NM_001098532	NP_001092002	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor 3 isoform	331					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			lung(2)|skin(1)|pancreas(1)	4	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GAAGGGCCGGCGCCCTGAGAG	0.597			NA											8	82					0	0	0.058154	0	0
DNAJC22	79962	broad.mit.edu	37	12	49745252	49745252	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:49745252T>A	uc001rua.2	+	3	1394	c.993T>A	c.(991-993)AGT>AGA	p.S331R	DNAJC22_uc001rub.2_Missense_Mutation_p.S331R	NM_024902	NP_079178	Q8N4W6	DJC22_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 22	331	J.				protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			ovary(1)	1						AAGTCCTGAGTCAACCCAGGA	0.562			NA											10	15					0	0	0.105934	0	0
HOXC9	3225	broad.mit.edu	37	12	54394137	54394137	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:54394137C>T	uc001sep.2	+	2	263	c.165C>T	c.(163-165)TTC>TTT	p.F55F	HOXC9_uc001seq.2_Silent_p.F55F	NM_006897	NP_008828	P31274	HXC9_HUMAN	homeobox C9	55					multicellular organismal development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)|skin(1)	3						CCTGTAGCTTCGCGCCCAAGC	0.687			NA											3	40					0	0	0.150653	0	0
BAZ2A	11176	broad.mit.edu	37	12	57000043	57000043	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:57000043C>T	uc001slq.1	-	12	2447	c.2253G>A	c.(2251-2253)AAG>AAA	p.K751K	BAZ2A_uc001slp.1_Silent_p.K749K|BAZ2A_uc009zov.1_5'Flank|BAZ2A_uc009zow.1_Silent_p.K719K	NM_013449	NP_038477	Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	751	Lys-rich.|Potential.				chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding				0						TGGATTTCTTCTTAGCTTCCT	0.398			NA											7	30					0	0	0.069234	0	0
BTBD11	121551	broad.mit.edu	37	12	107713770	107713770	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:107713770G>A	uc001tmk.1	+	1	1574	c.1053G>A	c.(1051-1053)CTG>CTA	p.L351L	BTBD11_uc009zut.1_Silent_p.L351L|BTBD11_uc001tmj.2_Silent_p.L351L	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	351						integral to membrane	DNA binding			skin(2)|ovary(1)	3						TGGAGACCCTGGAGCACACGG	0.443			NA											11	25					0	0	0.069234	0	0
NOS1	4842	broad.mit.edu	37	12	117681123	117681123	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:117681123C>A	uc001twm.1	-	19	3627	c.2941G>T	c.(2941-2943)GAA>TAA	p.E981*		NM_000620	NP_000611	P29475	NOS1_HUMAN	nitric oxide synthase 1, neuronal	981					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			ovary(3)|skin(3)|pancreas(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TCTGGAGCTTCGGCCACAAAG	0.517	Esophageal Squamous(162;1748 2599 51982 52956)		NA											25	47					1.17739e-12	1.43743e-12	0.108266	1	0
GOLGA3	2802	broad.mit.edu	37	12	133375030	133375030	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr12:133375030G>T	uc001ukz.1	-	9	2393	c.1834C>A	c.(1834-1836)CAC>AAC	p.H612N	GOLGA3_uc001ula.1_Missense_Mutation_p.H612N|GOLGA3_uc001ulb.2_Missense_Mutation_p.H612N	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	612	Gln-rich.|Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		AGTTTCAGGTGCTCCAGGAGA	0.517			NA											18	48					6.94344e-10	8.0334e-10	0.175082	1	0
GPR12	2835	broad.mit.edu	37	13	27333689	27333689	+	Silent	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr13:27333689C>A	uc010aal.2	-	2	498	c.276G>T	c.(274-276)CTG>CTT	p.L92L	GPR12_uc010tdl.1_Intron	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	92	Helical; Name=2; (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		CAATGCCGGCCAGCAGGTCTG	0.532			NA											21	32					7.92952e-12	9.44895e-12	0.0918	1	0
MYCBP2	23077	broad.mit.edu	37	13	77847655	77847655	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr13:77847655G>A	uc001vkf.2	-	6	874	c.783C>T	c.(781-783)ATC>ATT	p.I261I	MYCBP2_uc010aev.2_5'UTR	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	261					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		GGATAGCAGAGATGGCCTGAA	0.428			NA											21	29					0	0	0.234183	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21788336	21788336	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:21788336G>A	uc001wag.2	+	11	1467	c.1467G>A	c.(1465-1467)GAG>GAA	p.E489E	RPGRIP1_uc001wah.2_Silent_p.E131E|RPGRIP1_uc001wai.2_Silent_p.E131E|RPGRIP1_uc001waj.1_5'Flank|RPGRIP1_uc001wak.2_5'Flank|RPGRIP1_uc010aim.2_5'Flank|RPGRIP1_uc001wal.2_5'Flank	NM_020366	NP_065099	Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator	489	Potential.				response to stimulus|visual perception	cilium				ovary(4)|breast(2)|pancreas(1)	7	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CTCAGATCGAGGTAAGAGCCT	0.428			NA											3	30					0	0	0.217242	0	0
STRN3	29966	broad.mit.edu	37	14	31371778	31371778	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:31371778C>T	uc001wqu.2	-	16	2317	c.2101G>A	c.(2101-2103)GAA>AAA	p.E701K	STRN3_uc001wqv.2_Missense_Mutation_p.E617K|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	701	WD 4.				negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		TGTCTATCTTCATGAGCAGTT	0.294			NA											5	74					0	0	0.217242	0	0
SAMD4A	23034	broad.mit.edu	37	14	55218249	55218249	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:55218249G>T	uc001xbb.2	+	5	1168	c.1167G>T	c.(1165-1167)TTG>TTT	p.L389F	SAMD4A_uc001xbc.2_Missense_Mutation_p.L301F	NM_015589	NP_056404	Q9UPU9	SMAG1_HUMAN	sterile alpha motif domain containing 4 isoform	390	SAM.				positive regulation of translation	cell junction|cytoplasm|dendrite|synapse|synaptosome	translation repressor activity				0						TGAAGTCTTTGGAAAGGGTAA	0.373			NA											7	83					0.00448238	0.0046947	0.047766	1	0
FBXO34	55030	broad.mit.edu	37	14	55818909	55818909	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:55818909A>G	uc001xbu.2	+	2	2046	c.1801A>G	c.(1801-1803)ACC>GCC	p.T601A	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.T601A	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	601	F-box.									ovary(2)|lung(2)|skin(1)	5						CCTTAAATGTACCTGCTGCTA	0.448			NA											34	34					0	0	0.193644	0	0
EXOC5	10640	broad.mit.edu	37	14	57676740	57676740	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:57676740C>A	uc001xct.2	-	16	1904	c.1653G>T	c.(1651-1653)TTG>TTT	p.L551F	EXOC5_uc001xcs.2_Missense_Mutation_p.L230F|EXOC5_uc010trg.1_Missense_Mutation_p.L496F|EXOC5_uc010trh.1_Missense_Mutation_p.L486F	NM_006544	NP_006535	O00471	EXOC5_HUMAN	SEC10 protein	551					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				ovary(2)|breast(1)	3						GTTCTGCAGCCAAAATATGCT	0.289			NA											3	12					0.004672	0.00484233	0.115264	1	0
SLC35F4	341880	broad.mit.edu	37	14	58033208	58033208	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:58033208C>A	uc001xdb.1	-	7	1309	c.1309G>T	c.(1309-1311)GTT>TTT	p.V437F	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.V278F	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TTTCCAGGAACGCTGAGCACT	0.483			NA											5	8					8.12818e-05	8.64978e-05	0.02938	1	0
KCNH5	27133	broad.mit.edu	37	14	63416975	63416975	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:63416975C>A	uc001xfx.2	-	7	1296	c.1245G>T	c.(1243-1245)AAG>AAT	p.K415N	KCNH5_uc001xfy.2_Missense_Mutation_p.K415N|KCNH5_uc001xfz.1_Missense_Mutation_p.K357N|KCNH5_uc001xga.2_Missense_Mutation_p.K357N	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	415	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ACAATGAATCCTTGCTGGGTC	0.463			NA											23	53					2.44723e-14	3.02484e-14	0.099896	1	0
ZFYVE1	53349	broad.mit.edu	37	14	73490979	73490979	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:73490979G>A	uc001xnm.2	-	2	878	c.238C>T	c.(238-240)CAT>TAT	p.H80Y	ZFYVE1_uc010arj.2_Missense_Mutation_p.H80Y	NM_021260	NP_067083	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1 isoform 1	80						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			skin(1)	1		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		CCTGGTAAATGCCCACTGAGA	0.537			NA											97	140					0	0	0.139131	0	0
AK7	122481	broad.mit.edu	37	14	96953381	96953381	+	Silent	SNP	T	T	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:96953381T>C	uc001yfn.2	+	17	2165	c.2121T>C	c.(2119-2121)CCT>CCC	p.P707P		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	707	DPY-30.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CCGAAGACCCTGTTGATTTTC	0.284			NA											23	40					0	0	0.083992	0	0
DIO3	1735	broad.mit.edu	37	14	102028667	102028667	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:102028667C>T	uc010txq.1	+	2	980	c.756C>T	c.(754-756)GAC>GAT	p.D252D	DIO3OS_uc001ykd.1_5'Flank|uc001yke.2_5'Flank|uc001ykf.2_5'Flank|uc001ykg.2_5'Flank|uc001ykh.3_5'Flank|MIR1247_hsa-mir-1247|MI0006382_5'Flank	NM_001362	NP_001353	P55073	IOD3_HUMAN	deiodinase, iodothyronine, type III	252	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process	endosome membrane|integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|thyroxine 5-deiodinase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		all_neural(303;0.185)				GTGGCCCCGACGGCTACCAGG	0.597			NA											3	58					0	0	0.115264	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104206830	104206830	+	Silent	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:104206830A>T	uc001yof.1	-	12	2206	c.1923T>A	c.(1921-1923)CCT>CCA	p.P641P	PPP1R13B_uc010awv.1_RNA|PPP1R13B_uc001yog.1_Silent_p.P508P	NM_015316	NP_056131	Q96KQ4	ASPP1_HUMAN	apoptosis-stimulating protein of p53, 1	641	Pro-rich.				apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			ovary(1)	1		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TACTTTCTGAAGGTGGCTGAG	0.622			NA											25	54					0	0	0.099896	0	0
CILP	8483	broad.mit.edu	37	15	65491330	65491330	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr15:65491330A>G	uc002aon.2	-	9	1475	c.1294T>C	c.(1294-1296)TGC>CGC	p.C432R		NM_003613	NP_003604	O75339	CILP1_HUMAN	cartilage intermediate layer protein	432					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				ovary(4)|pancreas(2)|skin(1)	7						TTAACAGGGCAGCGTCCCACG	0.527			NA											4	35					0	0	0.184627	0	0
CHRNB4	1143	broad.mit.edu	37	15	78921866	78921866	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr15:78921866C>G	uc002bed.1	-	5	893	c.781G>C	c.(781-783)GGC>CGC	p.G261R	CHRNB4_uc002bee.1_Intron|CHRNB4_uc010blh.1_Missense_Mutation_p.G79R	NM_000750	NP_000741	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4	261	Cytoplasmic (Potential).				regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						ATCTTCTCGCCGCAGTCGGAT	0.567			NA											7	84					0	0	0.047766	0	0
HOMER2	9455	broad.mit.edu	37	15	83523419	83523419	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr15:83523419C>G	uc002bjg.2	-	6	847	c.661G>C	c.(661-663)GAG>CAG	p.E221Q	HOMER2_uc002bjh.2_Missense_Mutation_p.E210Q|HOMER2_uc002bjj.2_Intron|HOMER2_uc002bji.2_Intron	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	221	Potential.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						CGGTCATTCTCATCACGGCAG	0.622			NA											6	16					0	0	0.02938	0	0
SMG1	23049	broad.mit.edu	37	16	18893522	18893522	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:18893522G>A	uc002dfm.2	-	10	1621	c.1258C>T	c.(1258-1260)CGG>TGG	p.R420W	SMG1_uc010bwb.2_Missense_Mutation_p.R280W	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	420	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						GGAGGACCCCGAATTGGGCTG	0.438			NA											6	10					0	0	0.217242	0	0
DNAH3	55567	broad.mit.edu	37	16	20952737	20952737	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:20952737G>A	uc010vbe.1	-	59	11640	c.11640C>T	c.(11638-11640)CTC>CTT	p.L3880L	DNAH3_uc010vbd.1_Silent_p.L1315L	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3880					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TGAATCTGATGAGCTCCTGCC	0.493			NA											155	262					0	0	0.139131	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29883532	29883532	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:29883532G>A	uc002duq.3	-	16	2919	c.2679C>T	c.(2677-2679)TTC>TTT	p.F893F	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Silent_p.F836F|SEZ6L2_uc002dur.3_Silent_p.F823F|SEZ6L2_uc002dus.3_Silent_p.F792F|SEZ6L2_uc010vec.1_Silent_p.F906F|SEZ6L2_uc010ved.1_Silent_p.F862F	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	893	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GCGGGTTGCTGAAGTCCGACT	0.587			NA											5	28					0	0	0.02938	0	0
SALL1	6299	broad.mit.edu	37	16	51171263	51171263	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:51171263C>T	uc010vgs.1	-	3	3766	c.3735G>A	c.(3733-3735)CTG>CTA	p.L1245L	SALL1_uc010vgr.1_Silent_p.L1148L|SALL1_uc010cbv.2_Silent_p.L97L	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	1245					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCTTCATCGCCAGCCCGTTGG	0.552	GBM(103;1352 1446 1855 4775 8890)		NA											13	34					0	0	0.11911	0	0
CHD9	80205	broad.mit.edu	37	16	53260328	53260328	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:53260328A>G	uc002ehb.2	+	4	2111	c.1947A>G	c.(1945-1947)ATA>ATG	p.I649M	CHD9_uc002egy.2_Missense_Mutation_p.I649M|CHD9_uc002egz.1_Missense_Mutation_p.I649M|CHD9_uc002eha.1_Missense_Mutation_p.I649M|CHD9_uc002ehc.2_Missense_Mutation_p.I649M|CHD9_uc002ehd.2_Missense_Mutation_p.I175M	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	649	Lys-rich.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CAGAAGATATAGAAGGGAAGC	0.299			NA											6	12					0	0	0.217242	0	0
ARL2BP	23568	broad.mit.edu	37	16	57284415	57284415	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:57284415G>A	uc002elf.1	+	5	628	c.386G>A	c.(385-387)AGA>AAA	p.R129K	ARL2BP_uc010vhl.1_Missense_Mutation_p.R129K	NM_012106	NP_036238	Q9Y2Y0	AR2BP_HUMAN	binder of Arl Two	129					maintenance of protein location in nucleus|positive regulation of tyrosine phosphorylation of Stat3 protein|signal transduction	centrosome|midbody|mitochondrial intermembrane space|nucleus|spindle	protein binding|small GTPase regulator activity|transcription coactivator activity				0						TTGGACTACAGAGCAGTAAGT	0.423			NA											12	26					0	0	0.09319	0	0
VAC14	55697	broad.mit.edu	37	16	70818036	70818036	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:70818036G>A	uc002ezm.2	-	5	832	c.574C>T	c.(574-576)CGG>TGG	p.R192W	VAC14_uc010cfw.2_5'UTR|VAC14_uc002ezn.2_Intron	NM_018052	NP_060522	Q08AM6	VAC14_HUMAN	Vac14 homolog	192	HEAT 3.				interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			pancreas(1)|skin(1)	2		Ovarian(137;0.0699)				ATGAACTGCCGGGCATACTGG	0.522			NA											4	62					0	0	0.217242	0	0
TRAF4	9618	broad.mit.edu	37	17	27074265	27074265	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr17:27074265C>T	uc002hcs.2	+	2	286	c.178C>T	c.(178-180)CCT>TCT	p.P60S	TRAF4_uc002hcq.1_Missense_Mutation_p.P60S	NM_004295	NP_004286	Q9BUZ4	TRAF4_HUMAN	TNF receptor-associated factor 4	60					apoptosis|positive regulation of JNK cascade|positive regulation of protein homodimerization activity|positive regulation of protein kinase activity|regulation of apoptosis|signal transduction	cytoskeleton|nucleus|perinuclear region of cytoplasm|tight junction	DNA binding|ubiquitin-protein ligase activity|WW domain binding|zinc ion binding			upper_aerodigestive_tract(1)|lung(1)	2	Lung NSC(42;0.01)		Epithelial(11;3.26e-05)|all cancers(11;0.000272)|OV - Ovarian serous cystadenocarcinoma(11;0.235)			GGACCAGCTTCCTCTGGACTA	0.602			NA											3	67					0	0	0.184627	0	0
KLHL10	317719	broad.mit.edu	37	17	39994186	39994186	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr17:39994186T>C	uc010cxr.2	+	1	144	c.2T>C	c.(1-3)ATG>ACG	p.M1T	NT5C3L_uc010wfu.1_5'Flank|NT5C3L_uc002hyb.3_5'Flank|NT5C3L_uc002hyc.3_5'Flank|NT5C3L_uc002hyd.3_5'Flank|NT5C3L_uc002hxy.3_5'Flank|NT5C3L_uc002hxz.3_5'Flank|NT5C3L_uc002hya.3_5'Flank|KLHL10_uc010wfv.1_Missense_Mutation_p.M1T|KLHL10_uc010wfw.1_5'UTR	NM_152467	NP_689680	Q6JEL2	KLH10_HUMAN	kelch-like 10	1						cytoplasm				ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		Breast(137;0.000162)				CAGGGTGCCATGGAGATGGAG	0.592			NA											68	96					0	0	0.139131	0	0
TEX2	55852	broad.mit.edu	37	17	62226339	62226340	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr17:62226339_62226340TC>AA	uc002jec.2	-	12	3546_3547	c.3373_3374GA>TT	c.(3373-3375)GAT>TTT	p.D1125F	TEX2_uc002jed.2_Missense_Mutation_p.D1132F|TEX2_uc002jee.2_Missense_Mutation_p.D1125F	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	1125					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		TCATGGCTGATCAGCAGCCTCC	0.515			NA											10	91					0	0	0.115264	0	0
GNAL	2774	broad.mit.edu	37	18	11752513	11752513	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr18:11752513G>C	uc010dkz.2	+	2	327	c.81G>C	c.(79-81)AAG>AAC	p.K27N	GNAL_uc002kqc.2_Intron|GNAL_uc002kqd.2_Missense_Mutation_p.K27N	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	27					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						CCAACAAAAAGATCGAGAAGC	0.637			NA											4	61					0	0	0.150653	0	0
C18orf34	374864	broad.mit.edu	37	18	30977173	30977173	+	Splice_Site	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr18:30977173C>A	uc002kxn.2	-	3	201	c.59_splice	c.e3-1	p.G20_splice	C18orf34_uc010xbr.1_Splice_Site_p.G20_splice|C18orf34_uc010dmf.1_Splice_Site_p.G20_splice|C18orf34_uc002kxo.2_Splice_Site_p.G20_splice|C18orf34_uc002kxp.2_Splice_Site_p.G20_splice	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1											ovary(1)	1						CATGTTAAACCTATAAAAGGT	0.333			NA											19	37					6.33239e-15	7.92544e-15	0.219247	1	0
FHOD3	80206	broad.mit.edu	37	18	34273362	34273362	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr18:34273362C>T	uc002kzt.1	+	13	1733	c.1636C>T	c.(1636-1638)CCA>TCA	p.P546S	FHOD3_uc002kzr.1_Missense_Mutation_p.P546S|FHOD3_uc002kzs.1_Missense_Mutation_p.P563S|FHOD3_uc010dmz.1_Missense_Mutation_p.P278S|FHOD3_uc010dna.1_5'UTR	NM_025135	NP_079411	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	546					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			skin(3)|large_intestine(2)|breast(2)|ovary(1)	8		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				TGCCTCCTCCCCAGGAACCCC	0.572			NA											5	25					0	0	0.02938	0	0
RTTN	25914	broad.mit.edu	37	18	67781805	67781805	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr18:67781805G>A	uc002lkp.2	-	27	3627	c.3559C>T	c.(3559-3561)CTG>TTG	p.L1187L	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_Silent_p.L275L	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	1187							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				GACTCTGTCAGAACCAAGAGG	0.373			NA											31	60					0	0	0.214465	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2399124	2399124	+	Silent	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:2399124G>T	uc010xgx.1	+	3	345	c.345G>T	c.(343-345)CGG>CGT	p.R115R	TMPRSS9_uc002lvv.1_Silent_p.R149R	NM_182973	NP_892018	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	115	Extracellular (Potential).				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGGATCCGGGCAAGGCTGC	0.622			NA											10	21					2.74318e-10	3.21113e-10	0.058154	1	0
EMR2	30817	broad.mit.edu	37	19	14875276	14875276	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:14875276C>T	uc002mzp.1	-	11	1509	c.1053G>A	c.(1051-1053)GGG>GGA	p.G351G	EMR2_uc010dzs.1_5'UTR|EMR2_uc010xnw.1_Silent_p.G351G|EMR2_uc002mzo.1_Silent_p.G351G|EMR2_uc002mzq.1_Silent_p.G302G|EMR2_uc002mzr.1_Silent_p.G302G|EMR2_uc002mzs.1_Silent_p.G209G|EMR2_uc002mzt.1_Silent_p.G258G|EMR2_uc002mzu.1_Silent_p.G258G|EMR2_uc010xnx.1_RNA|EMR2_uc010xny.1_RNA	NM_013447	NP_038475	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone	351	Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			lung(2)|ovary(1)|skin(1)	4						AGTTCAACAGCCCATTGGAAA	0.572			NA											4	26					0	0	0.217242	0	0
NCAN	1463	broad.mit.edu	37	19	19337426	19337426	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:19337426C>A	uc002nlz.2	+	7	1303	c.1204C>A	c.(1204-1206)CCT>ACT	p.P402T	NCAN_uc010ecc.1_5'UTR	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	402					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GGTGGTCACCCCTGACTTCCA	0.597			NA											4	26					0.00909568	0.0093301	0.150653	1	0
NCAN	1463	broad.mit.edu	37	19	19338673	19338673	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:19338673G>A	uc002nlz.2	+	8	2343	c.2244G>A	c.(2242-2244)ACG>ACA	p.T748T	NCAN_uc010ecc.1_Silent_p.T312T	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	748					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			CTGAGCCAACGGGCCTCAGGG	0.582			NA											8	79					0	0	0.058154	0	0
GMIP	51291	broad.mit.edu	37	19	19744910	19744910	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:19744910G>A	uc002nnd.2	-	19	2291	c.2174C>T	c.(2173-2175)CCG>CTG	p.P725L	GMIP_uc010xrb.1_Missense_Mutation_p.P699L|GMIP_uc010xrc.1_Missense_Mutation_p.P696L	NM_016573	NP_057657	Q9P107	GMIP_HUMAN	GEM interacting protein	725	Rho-GAP.				negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			ovary(1)	1						GGCTGCCCGCGGGCCGTCCGG	0.617			NA											4	55					0	0	0.150653	0	0
UQCRFS1	7386	broad.mit.edu	37	19	29698679	29698679	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:29698679C>G	uc002nsd.2	-	2	712	c.601G>C	c.(601-603)GAT>CAT	p.D201H		NM_006003	NP_005994	P47985	UCRI_HUMAN	ubiquinol-cytochrome c reductase, Rieske	201	Rieske.				respiratory electron transport chain	integral to membrane|mitochondrial respiratory chain complex III	2 iron, 2 sulfur cluster binding|metal ion binding|ubiquinol-cytochrome-c reductase activity				0	Breast(6;0.0545)|Esophageal squamous(110;0.239)		Lung(7;0.092)			CGATCTAGATCATGCTGTGGG	0.453			NA											27	93					0	0	0.163468	0	0
PRKD2	25865	broad.mit.edu	37	19	47181778	47181778	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:47181778C>A	uc002pfh.2	-	17	2555	c.2213G>T	c.(2212-2214)GGC>GTC	p.G738V	PRKD2_uc002pfd.2_Missense_Mutation_p.G112V|PRKD2_uc010eks.2_Missense_Mutation_p.G141V|PRKD2_uc010ekt.2_Missense_Mutation_p.G5V|PRKD2_uc002pfe.2_Missense_Mutation_p.G258V|PRKD2_uc002pff.2_Missense_Mutation_p.G258V|PRKD2_uc002pfg.2_Missense_Mutation_p.G581V|PRKD2_uc002pfi.2_Missense_Mutation_p.G738V|PRKD2_uc002pfj.2_Missense_Mutation_p.G738V|PRKD2_uc010xye.1_Missense_Mutation_p.G738V|PRKD2_uc002pfk.2_Missense_Mutation_p.G581V	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	738	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		CATGATCACGCCCACTGACCA	0.617			NA											20	47					9.95505e-16	1.26182e-15	0.069288	1	0
GRLF1	2909	broad.mit.edu	37	19	47424426	47424426	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:47424426C>T	uc010ekv.2	+	1	2494	c.2494C>T	c.(2494-2496)CGG>TGG	p.R832W		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	832					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		GCACAAGAAGCGGATTGAACT	0.423			NA											3	61					0	0	0.184627	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022413	51022413	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:51022413C>T	uc002pss.2	-	3	694	c.557G>A	c.(556-558)CGC>CAC	p.R186H		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	186	LRR 5.|Extracellular (Potential).					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		CAGGTCCAGGCGCCGCAGCGA	0.652			NA											8	28					0	0	0.038147	0	0
KLK13	26085	broad.mit.edu	37	19	51563323	51563323	+	Missense_Mutation	SNP	G	G	T	rs138178458	byFrequency	TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:51563323G>T	uc002pvn.2	-	3	310	c.267C>A	c.(265-267)CAC>CAA	p.H89Q	KLK13_uc002pvl.2_RNA|KLK13_uc002pvm.2_RNA|KLK13_uc002pvo.2_RNA|KLK13_uc002pvp.2_RNA|KLK13_uc010eon.2_Missense_Mutation_p.H89Q|KLK13_uc002pvq.2_RNA|KLK13_uc010eoo.2_Intron|KLK13_uc002pvr.2_Missense_Mutation_p.H89Q	NM_015596	NP_056411	Q9UKR3	KLK13_HUMAN	kallikrein 13 precursor	89	Peptidase S1.				proteolysis		protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00224)|GBM - Glioblastoma multiforme(134;0.00432)		GCCCTAGGGCGTGCTTGCCTA	0.478			NA											12	53					8.60227e-14	1.0567e-13	0.146539	1	0
SIGLEC14	100049587	broad.mit.edu	37	19	52147227	52147227	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:52147227C>T	uc002pxf.3	-	5	937	c.817G>A	c.(817-819)GCC>ACC	p.A273T		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	273	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		ACTGTGCAGGCGAGGAACAGG	0.617			NA											6	9					0	0	0.217242	0	0
ZNF761	388561	broad.mit.edu	37	19	53959918	53959918	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:53959918G>T	uc010eqp.2	+	7	2615	c.2157G>T	c.(2155-2157)AAG>AAT	p.K719N	ZNF761_uc010ydy.1_Missense_Mutation_p.K665N|ZNF761_uc002qbt.1_Missense_Mutation_p.K665N	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	719	C2H2-type 19.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AACCTTACAAGTGTAATGAGT	0.398			NA											36	107					3.33393e-15	4.19907e-15	0.214465	1	0
ZIM2	23619	broad.mit.edu	37	19	57301308	57301308	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr19:57301308G>C	uc002qnr.2	-	8	791	c.409C>G	c.(409-411)CAG>GAG	p.Q137E	uc010ygp.1_RNA|uc002qnp.1_RNA|ZIM2_uc010ygq.1_5'UTR|ZIM2_uc010ygr.1_5'UTR|ZIM2_uc002qnq.2_Missense_Mutation_p.Q137E|ZIM2_uc010etp.2_Missense_Mutation_p.Q137E|ZIM2_uc010ygs.1_Missense_Mutation_p.Q137E	NM_015363	NP_056178	Q9NZV7	ZIM2_HUMAN	zinc finger, imprinted 2	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)	3		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		ACAGAGTCCTGAGCAAGGAAA	0.522			NA											8	16					0	0	0.069234	0	0
SLC8A1	6546	broad.mit.edu	37	2	40655667	40655667	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:40655667C>T	uc002rrx.2	-	1	1778	c.1754G>A	c.(1753-1755)GGG>GAG	p.G585E	SLC8A1_uc002rry.2_Missense_Mutation_p.G585E|SLC8A1_uc002rrz.2_Missense_Mutation_p.G585E|SLC8A1_uc002rsa.2_Missense_Mutation_p.G585E|SLC8A1_uc002rsd.3_Missense_Mutation_p.G585E|SLC8A1_uc002rsb.1_Missense_Mutation_p.G585E|SLC8A1_uc010fan.1_Missense_Mutation_p.G585E|SLC8A1_uc002rsc.1_Missense_Mutation_p.G585E	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	585	Calx-beta 2.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AAAATCCTCCCCTCCACCTCT	0.363			NA											16	40					0	0	0.146539	0	0
ANTXR1	84168	broad.mit.edu	37	2	69318050	69318050	+	Silent	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:69318050A>G	uc002sfg.2	+	9	1058	c.702A>G	c.(700-702)GGA>GGG	p.G234G	ANTXR1_uc002sfe.2_Silent_p.G234G|ANTXR1_uc002sff.2_Silent_p.G234G|ANTXR1_uc002sfd.2_Silent_p.G234G	NM_032208	NP_115584	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1 isoform 1 precursor	234	Extracellular (Potential).				actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			ovary(2)|skin(2)	4						TATGTGCAGGAGGTAAATTGA	0.388			NA							Familial_Infantile_Hemangioma				4	48					0	0	0.184627	0	0
EIF5B	9669	broad.mit.edu	37	2	99978277	99978277	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:99978277G>A	uc002tab.2	+	4	1097	c.913G>A	c.(913-915)GCA>ACA	p.A305T		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	305					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						TCCCACAGCTGCAGAAGGTTG	0.388	Colon(162;2388 2567 2705 3444)		NA											36	51					0	0	0.203993	0	0
C2orf29	55571	broad.mit.edu	37	2	101885540	101885540	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:101885540A>T	uc002taw.3	+	6	1359	c.1277A>T	c.(1276-1278)CAC>CTC	p.H426L		NM_017546	NP_060016	Q9UKZ1	CB029_HUMAN	hypothetical protein LOC55571	426					cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol				ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						GAATTTATTCACCTTTATATA	0.294			NA											6	27					0	0	0.02938	0	0
RGPD4	285190	broad.mit.edu	37	2	108475942	108475942	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:108475942A>T	uc010ywk.1	+	11	1648	c.1566A>T	c.(1564-1566)AAA>AAT	p.K522N	RGPD4_uc002tdu.2_5'UTR|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	522					intracellular transport		binding			skin(2)	2						CTGTATGTAAACAGCTTTGTA	0.393			NA											88	221					0	0	0.139131	0	0
LRP1B	53353	broad.mit.edu	37	2	141625810	141625811	+	Missense_Mutation	DNP	CC	CC	TA			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:141625810_141625811CC>TA	uc002tvj.1	-	26	5163_5164	c.4191_4192GG>TA	c.(4189-4194)TGGGAT>TGTAAT	p.1397_1398WD>CN	LRP1B_uc010fnl.1_Missense_Mutation_p.579_580WD>CN	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1397_1398	Extracellular (Potential).|LDL-receptor class B 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AAATTTGCATCCCAGTCTGTCC	0.287	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			7	39					0	0	0.115264	0	0
NR4A2	4929	broad.mit.edu	37	2	157182419	157182419	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:157182419C>T	uc002tyz.3	-	8	2056	c.1634G>A	c.(1633-1635)GGG>GAG	p.G545E	NR4A2_uc002tyx.3_Missense_Mutation_p.G482E|NR4A2_uc010zcf.1_Missense_Mutation_p.G545E	NM_006186	NP_006177	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	545					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GCGGTTCAACCCCCCATTGTT	0.478			NA											3	60					0	0	0.150653	0	0
TTN	7273	broad.mit.edu	37	2	179616751	179616751	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:179616751C>A	uc002unb.2	-	46	10600	c.10376G>T	c.(10375-10377)GGG>GTG	p.G3459V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGATTCCCCCTCAGAGAA	0.323			NA											18	89					3.51602e-12	4.24053e-12	0.204396	1	0
PIKFYVE	200576	broad.mit.edu	37	2	209190010	209190010	+	Silent	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:209190010G>T	uc002vcz.2	+	20	2633	c.2475G>T	c.(2473-2475)CTG>CTT	p.L825L	PIKFYVE_uc010fun.1_Silent_p.L506L|PIKFYVE_uc002vcy.1_Silent_p.L769L	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	825					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						CCAAGACACTGATGTTTTTTG	0.378			NA											5	26					0.00198382	0.00208878	0.02938	1	0
FRG1B	284802	broad.mit.edu	37	20	29625875	29625875	+	Missense_Mutation	SNP	T	T	C	rs143761036	by1000genomes	TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr20:29625875T>C	uc010ztl.1	+	2	61	c.29T>C	c.(28-30)ATC>ACC	p.I10T	FRG1B_uc002wvm.1_RNA|FRG1B_uc010ztj.1_RNA|FRG1B_uc010gdr.1_RNA|FRG1B_uc010ztk.1_Intron					Homo sapiens cDNA FLJ32537 fis, clone SMINT2000400, highly similar to Homo sapiens FRG1 mRNA.												0						ATGTACAGAATCGCCCTGAAA	0.353			NA											4	64					0	0	0.217242	0	0
TPX2	22974	broad.mit.edu	37	20	30345327	30345327	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr20:30345327C>T	uc002wwp.1	+	3	746	c.48C>T	c.(46-48)TTC>TTT	p.F16F	TPX2_uc010gdv.1_Silent_p.F16F	NM_012112	NP_036244	Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated protein homolog	16					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			large_intestine(1)|ovary(1)	2			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			CCTCGGATTTCATCAATTTTT	0.398			NA											17	57					0	0	0.189662	0	0
GTPBP5	26164	broad.mit.edu	37	20	60768505	60768505	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr20:60768505G>T	uc002yce.3	+	2	67	c.29G>T	c.(28-30)AGA>ATA	p.R10I	GTPBP5_uc011aab.1_Intron|GTPBP5_uc011aac.1_Intron|GTPBP5_uc011aad.1_5'UTR|GTPBP5_uc011aae.1_Intron|GTPBP5_uc011aaf.1_Missense_Mutation_p.R10I|GTPBP5_uc011aag.1_Missense_Mutation_p.R10I	NM_015666	NP_056481	Q9H4K7	GTPB5_HUMAN	GTP binding protein 5	10					ribosome biogenesis	mitochondrion	GTP binding|GTPase activity|magnesium ion binding				0	Breast(26;3.52e-09)		BRCA - Breast invasive adenocarcinoma(19;2.5e-08)			TTCTCAGCAAGATTGAGGACC	0.542			NA											7	116					1.12685e-05	1.25276e-05	0.047766	1	0
COL9A3	1299	broad.mit.edu	37	20	61460123	61460123	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr20:61460123C>A	uc002ydm.2	+	18	911	c.908C>A	c.(907-909)CCG>CAG	p.P303Q		NM_001853	NP_001844	Q14050	CO9A3_HUMAN	alpha 3 type IX collagen precursor	303	Triple-helical region 3 (COL3).				axon guidance	collagen type IX					0	Breast(26;5.68e-08)					CAGGGCATGCCGGGCAAGGAC	0.682			NA											9	28					2.17888e-05	2.3824e-05	0.058154	1	0
HSPA13	6782	broad.mit.edu	37	21	15750686	15750686	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr21:15750686C>A	uc002yjt.2	-	3	483	c.414G>T	c.(412-414)GAG>GAT	p.E138D	HSPA13_uc011abx.1_Intron	NM_006948	NP_008879	P48723	HSP13_HUMAN	heat shock protein 70kDa family member 13	138						endoplasmic reticulum|microsome	ATP binding			kidney(1)	1						CTGTGATGGTCTCATTACTTG	0.333			NA											10	38					1.61879e-10	1.90615e-10	0.09319	1	0
C21orf63	59271	broad.mit.edu	37	21	33887132	33887132	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr21:33887132G>C	uc002ypr.1	+	8	1368	c.958G>C	c.(958-960)GAG>CAG	p.E320Q	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.E317Q|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.E225Q|C21orf63_uc011adq.1_Silent_p.R19R	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	320	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						AGCCCACCCGGAGAGAGCTGC	0.612			NA											7	88					0	0	0.058154	0	0
U2AF1	7307	broad.mit.edu	37	21	44524456	44524456	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr21:44524456G>A	uc002zda.1	-	2	185	c.101C>T	c.(100-102)TCT>TTT	p.S34F	U2AF1_uc002zcy.1_5'UTR|U2AF1_uc002zcz.1_5'UTR|U2AF1_uc002zdb.1_Missense_Mutation_p.S34F|U2AF1_uc010gpi.1_Missense_Mutation_p.S34F|U2AF1_uc002zdc.1_Missense_Mutation_p.S34F	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	34	C3H1-type 1.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						GTGCAACCGAGAGCACCTGTC	0.358			NA											7	24					0	0	0.047766	0	0
DIP2A	23181	broad.mit.edu	37	21	47916917	47916917	+	Silent	SNP	C	C	T	rs139510335	by1000genomes	TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr21:47916917C>T	uc002zjo.2	+	4	483	c.300C>T	c.(298-300)GCC>GCT	p.A100A	DIP2A_uc011afy.1_Silent_p.A36A|DIP2A_uc011afz.1_Silent_p.A100A|DIP2A_uc002zjl.2_Silent_p.A100A|DIP2A_uc002zjm.2_Silent_p.A100A|DIP2A_uc010gql.2_Silent_p.A100A|DIP2A_uc002zjn.2_Silent_p.A100A	NM_015151	NP_055966	Q14689	DIP2A_HUMAN	disco-interacting protein 2A isoform a	100					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			ovary(2)	2	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		ACACTGAAGCCGTGCAAGCAG	0.408			NA											5	22					0	0	0.217242	0	0
CCDC116	164592	broad.mit.edu	37	22	21991356	21991356	+	Silent	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr22:21991356C>A	uc002zve.2	+	5	1932	c.1839C>A	c.(1837-1839)GTC>GTA	p.V613V		NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	Error:Variant_position_missing_in_Q8IYX3_after_alignment										ovary(1)|skin(1)	2	Colorectal(54;0.105)					aggaTGGAGTCTAGAGCCTCC	0.453			NA											3	7					0.004672	0.00484233	0.115264	1	0
MN1	4330	broad.mit.edu	37	22	28193018	28193018	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr22:28193018C>A	uc003adj.2	-	1	4469	c.3514G>T	c.(3514-3516)GAC>TAC	p.D1172Y		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1172							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						AGAGGCTGGTCCTCGGAGATG	0.677			NA	T	ETV6	AML|meningioma								3	12					0.00909568	0.0093301	0.150653	1	0
NCAPH2	29781	broad.mit.edu	37	22	50956689	50956689	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr22:50956689A>T	uc003blr.3	+	7	750	c.628A>T	c.(628-630)ATG>TTG	p.M210L	NCAPH2_uc003blq.3_Missense_Mutation_p.M210L|NCAPH2_uc003blv.2_Missense_Mutation_p.M210L|NCAPH2_uc010hbb.2_Missense_Mutation_p.M61L|NCAPH2_uc003blu.3_RNA|NCAPH2_uc003bls.3_RNA|NCAPH2_uc003blt.3_RNA|NCAPH2_uc003blw.3_RNA|NCAPH2_uc003blx.3_Missense_Mutation_p.M210L|NCAPH2_uc003bly.3_RNA	NM_152299	NP_689512	Q6IBW4	CNDH2_HUMAN	kleisin beta isoform 2	210					chromosome condensation	chromosome|nucleus				ovary(1)|skin(1)	2		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CGTTTCCCCCATGCCAGGGAC	0.627			NA											7	33					0	0	0.038147	0	0
CISH	1154	broad.mit.edu	37	3	50645182	50645182	+	Silent	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr3:50645182C>A	uc003dax.2	-	3	814	c.633G>T	c.(631-633)GTG>GTT	p.V211V	CISH_uc010hlq.2_Silent_p.V228V	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	211	SOCS box.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CAAAGGGCTGCACCAGTTTTA	0.637			NA											41	95					6.87076e-12	8.23664e-12	0.139131	1	0
GPR128	84873	broad.mit.edu	37	3	100356215	100356215	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr3:100356215G>A	uc003duc.2	+	6	935	c.667G>A	c.(667-669)GCT>ACT	p.A223T	GPR128_uc011bhc.1_Silent_p.L6L	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	223	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TCAAAGAGTTGCTGCTACTGC	0.393	Pancreas(87;185 1975 7223 18722)		NA											35	52					0	0	0.09836	0	0
IGSF10	285313	broad.mit.edu	37	3	151164743	151164743	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr3:151164743C>G	uc011bod.1	-	4	3026	c.3026G>C	c.(3025-3027)CGC>CCC	p.R1009P		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1009					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTCCCAAAGCGTCTGAACAG	0.488			NA											31	47					0	0	0.183431	0	0
SCHIP1	29970	broad.mit.edu	37	3	159606673	159606673	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr3:159606673G>A	uc003fcs.1	+	6	1325	c.1259G>A	c.(1258-1260)AGA>AAA	p.R420K	SCHIP1_uc003fcq.1_Missense_Mutation_p.R496K|SCHIP1_uc003fcr.1_Missense_Mutation_p.R409K|SCHIP1_uc003fct.1_Missense_Mutation_p.R407K|SCHIP1_uc010hvz.1_Missense_Mutation_p.R380K|SCHIP1_uc003fcu.1_Missense_Mutation_p.R177K|SCHIP1_uc003fcv.1_Missense_Mutation_p.R193K	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	420						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			ACCGACCTGAGAGACATGACT	0.388			NA											25	69					0	0	0.0918	0	0
SLIT2	9353	broad.mit.edu	37	4	20620487	20620487	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:20620487G>T	uc003gpr.1	+	37	4649	c.4445G>T	c.(4444-4446)TGC>TTC	p.C1482F	SLIT2_uc003gps.1_Missense_Mutation_p.C1474F	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	1482	CTCK.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						CGATTAGAGTGCAGAGGTGGG	0.527			NA											19	14					8.10497e-08	9.26948e-08	0.219247	1	0
PPARGC1A	10891	broad.mit.edu	37	4	23803877	23803877	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:23803877T>A	uc003gqs.2	-	11	2231	c.2111A>T	c.(2110-2112)GAG>GTG	p.E704V	PPARGC1A_uc003gqt.2_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	704	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				TGTGCACTCCTCAATTTCACC	0.418	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											60	25					0	0	0.139131	0	0
ANAPC4	29945	broad.mit.edu	37	4	25417102	25417102	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:25417102G>T	uc003gro.2	+	26	1970	c.1841G>T	c.(1840-1842)GGA>GTA	p.G614V	ANAPC4_uc003grp.2_Missense_Mutation_p.G500V|ANAPC4_uc003grq.2_Missense_Mutation_p.G67V	NM_013367	NP_037499	Q9UJX5	APC4_HUMAN	anaphase-promoting complex subunit 4	614					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5		Breast(46;0.0503)				GTGAGTAATGGACTAATTGCT	0.353			NA											10	8					3.07112e-06	3.45284e-06	0.080935	1	0
AFP	174	broad.mit.edu	37	4	74306366	74306366	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:74306366G>T	uc003hgz.1	+	4	365	c.318G>T	c.(316-318)GAG>GAT	p.E106D	AFP_uc003hha.1_Missense_Mutation_p.E106D|AFP_uc011cbg.1_5'Flank	NM_001134	NP_001125	P02771	FETA_HUMAN	alpha-fetoprotein precursor	106	Albumin 1.				transport		metal ion binding			ovary(1)	1	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAATTTTGGAGAAGTACGGAC	0.393			NA							Alpha-Fetoprotein_Hereditary_Persistence_of				47	47					7.92265e-33	1.06527e-32	0.139131	1	0
SHROOM3	57619	broad.mit.edu	37	4	77677649	77677649	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:77677649C>T	uc011cbx.1	+	8	5710	c.4757C>T	c.(4756-4758)CCT>CTT	p.P1586L	SHROOM3_uc003hkg.2_Missense_Mutation_p.P1364L	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1586					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			AGGCACATGCCTGGTGCAGCC	0.403			NA											8	21					0	0	0.047766	0	0
PCDH10	57575	broad.mit.edu	37	4	134073114	134073114	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:134073114G>A	uc003iha.2	+	1	2645	c.1819G>A	c.(1819-1821)GAC>AAC	p.D607N	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.D607N	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	607	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GGCCGCCGTGGACGCGGACGA	0.692			NA											14	51					0	0	0.105934	0	0
DCHS2	54798	broad.mit.edu	37	4	155158151	155158151	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:155158151G>A	uc003inw.2	-	25	6288	c.6288C>T	c.(6286-6288)GTC>GTT	p.V2096V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2096	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TATAGGATTTGACTGTGAATT	0.423			NA											4	160					0	0	0.184627	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160268001	160268001	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:160268001G>T	uc003iqg.3	+	19	3390	c.3080G>T	c.(3079-3081)AGG>ATG	p.R1027M		NM_014247	NP_055062	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor 2	1027					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			lung(2)|upper_aerodigestive_tract(1)|skin(1)	4	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		GTAGCTCCAAGGGCAGGGTCA	0.498			NA											31	67					3.11337e-16	3.97155e-16	0.173368	1	0
FAM134B	54463	broad.mit.edu	37	5	16572124	16572124	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:16572124C>A	uc003jfs.2	-	2	446	c.408G>T	c.(406-408)ATG>ATT	p.M136I		NM_001034850	NP_001030022	Q9H6L5	F134B_HUMAN	hypothetical protein LOC54463 isoform 1	136	Helical; (Potential).				sensory perception of pain	cis-Golgi network|endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3						TAGACAAAACCATATCCTTTA	0.363			NA											8	54					3.09899e-07	3.50397e-07	0.047766	1	0
CDH9	1007	broad.mit.edu	37	5	26881724	26881724	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:26881724C>T	uc003jgs.1	-	12	2060	c.1891G>A	c.(1891-1893)GTG>ATG	p.V631M	CDH9_uc011cnv.1_Missense_Mutation_p.V224M	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	631	Helical; (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						GCAAACAACACGACTAAAACT	0.388	Melanoma(8;187 585 15745 40864 52829)		NA											5	27					0	0	0.184627	0	0
C9	735	broad.mit.edu	37	5	39341264	39341264	+	Nonsense_Mutation	SNP	G	G	A	rs144138616		TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:39341264G>A	uc003jlv.3	-	4	549	c.460C>T	c.(460-462)CGA>TGA	p.R154*		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	154	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			CCTGCTGTTCGTGCCAGCTCA	0.458			NA											41	111					0	0	0.139131	0	0
ZNF131	7690	broad.mit.edu	37	5	43175089	43175089	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:43175089G>T	uc011cpw.1	+	7	1762	c.1726G>T	c.(1726-1728)GAG>TAG	p.E576*	ZNF131_uc003jnj.3_Nonsense_Mutation_p.E297*|ZNF131_uc003jnk.2_Nonsense_Mutation_p.E542*|ZNF131_uc003jnn.3_Nonsense_Mutation_p.E297*|ZNF131_uc003jnl.1_Intron|ZNF131_uc010ivm.1_Intron	NM_003432	NP_003423	P52739	ZN131_HUMAN	zinc finger protein 131	576						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						GAACCAAGAGGAGAGAGAGTC	0.488			NA											18	44					6.94344e-10	8.0334e-10	0.175082	1	0
HCN1	348980	broad.mit.edu	37	5	45262605	45262605	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:45262605G>A	uc003jok.2	-	8	2116	c.2091C>T	c.(2089-2091)TGC>TGT	p.C697C		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	697	Cytoplasmic (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						TGGTGTAGGAGCAGGGTGACA	0.632			NA											11	31					0	0	0.080935	0	0
MCCC2	64087	broad.mit.edu	37	5	70946009	70946009	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:70946009A>G	uc003kbs.3	+	15	1625	c.1487A>G	c.(1486-1488)CAG>CGG	p.Q496R	MCCC2_uc003kbt.3_RNA	NM_022132	NP_071415	Q9HCC0	MCCB_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 2 (beta)	496	Carboxyltransferase.				leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)	1		Lung NSC(167;0.000697)|Prostate(74;0.0107)|Ovarian(174;0.0175)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.04e-54)	Biotin(DB00121)	GAAGGAAAGCAGGTCGGTGTC	0.527			NA											16	31					0	0	0.160694	0	0
TBCA	6902	broad.mit.edu	37	5	76987267	76987267	+	Silent	SNP	C	C	T	rs147194873		TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:76987267C>T	uc003kfh.1	-	4	407	c.303G>A	c.(301-303)CTG>CTA	p.L101L	TBCA_uc003kfi.1_3'UTR	NM_004607	NP_004598	O75347	TBCA_HUMAN	tubulin-specific chaperone a	101					'de novo' posttranslational protein folding|post-chaperonin tubulin folding pathway|tubulin complex assembly	cytoplasm|microtubule	chaperone binding|unfolded protein binding			ovary(1)	1		all_lung(232;0.000511)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;1.02e-49)|Epithelial(54;1.05e-44)|all cancers(79;4.08e-40)		TCACTGAATCCAGTACTAAAC	0.333			NA											3	12					0	0	0.184627	0	0
AP3B1	8546	broad.mit.edu	37	5	77477446	77477446	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:77477446G>A	uc003kfj.2	-	8	952	c.827C>T	c.(826-828)TCT>TTT	p.S276F		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	276					endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		ATCATCATCAGATTCGTAGAA	0.348			NA							Hermansky-Pudlak_syndrome				9	15					0	0	0.058154	0	0
ARSB	411	broad.mit.edu	37	5	78251288	78251288	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:78251288T>C	uc003kfq.2	-	4	2014	c.728A>G	c.(727-729)GAG>GGG	p.E243G	ARSB_uc003kfr.3_Missense_Mutation_p.E243G	NM_000046	NP_000037	P15848	ARSB_HUMAN	arylsulfatase B isoform 1 precursor	243					lysosomal transport|lysosome organization	lysosome	arylsulfatase activity|metal ion binding|N-acetylgalactosamine-4-sulfatase activity			upper_aerodigestive_tract(1)	1		all_lung(232;0.000637)|Lung NSC(167;0.00173)|Ovarian(174;0.0105)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;4.24e-44)|Epithelial(54;3.12e-39)|all cancers(79;3.02e-34)		CTGAAGGGGCTCATGCACAGA	0.428	Melanoma(169;563 1968 25780 26156 52266)		NA											9	46					0	0	0.069234	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101813454	101813454	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:101813454C>G	uc003knn.2	-	3	900	c.728G>C	c.(727-729)GGA>GCA	p.G243A	SLCO6A1_uc003kno.2_Intron|SLCO6A1_uc003knp.2_Missense_Mutation_p.G243A|SLCO6A1_uc003knq.2_Intron	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	243	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AAGAGGCATTCCTGCTATTCC	0.408			NA											53	97					0	0	0.139131	0	0
MEGF10	84466	broad.mit.edu	37	5	126755842	126755842	+	Silent	SNP	C	C	T	rs151266058	byFrequency	TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:126755842C>T	uc003kuh.3	+	13	1895	c.1533C>T	c.(1531-1533)GAC>GAT	p.D511D	MEGF10_uc010jdc.1_Silent_p.D511D|MEGF10_uc010jdd.1_Silent_p.D511D|MEGF10_uc003kui.3_Silent_p.D511D	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	511	Extracellular (Potential).|EGF-like 9.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup		p.D511D(1)		ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACACCCTGGACGGGACCTGCA	0.592			NA											30	61					0	0	0.225048	0	0
GFRA3	2676	broad.mit.edu	37	5	137600050	137600050	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:137600050G>A	uc003lcn.2	-	2	419	c.279C>T	c.(277-279)CTC>CTT	p.L93L	GFRA3_uc003lco.2_Silent_p.L93L	NM_001496	NP_001487	O60609	GFRA3_HUMAN	GDNF family receptor alpha 3 preproprotein	93					peripheral nervous system development	anchored to membrane|cytoplasm|extrinsic to membrane|intracellular membrane-bounded organelle	receptor binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			AGCTGTTCCTGAGTTGCTGTG	0.597			NA											8	31					0	0	0.038147	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188828	140188828	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:140188828G>C	uc003lhi.2	+	1	2157	c.2056G>C	c.(2056-2058)GCT>CCT	p.A686P	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Missense_Mutation_p.A686P|PCDHA4_uc011daa.1_Missense_Mutation_p.A686P	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	686	Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTGGTGGGCGCTGTGGGTCC	0.642			NA											15	32					0	0	0.160694	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516913	140516913	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:140516913G>A	uc003liq.2	+	1	2114	c.1897G>A	c.(1897-1899)GAC>AAC	p.D633N		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	633	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCGAGCGCGACGCGGCCAA	0.692			NA											23	50					0	0	0.108266	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626348	140626348	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:140626348A>G	uc003lje.2	+	1	1202	c.1202A>G	c.(1201-1203)TAC>TGC	p.Y401C		NM_018935	NP_061758	Q9Y5E8	PCDBF_HUMAN	protocadherin beta 15 precursor	401	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(2)|breast(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGAATTTCTACAGGCTGGTA	0.458			NA											15	27					0	0	0.132662	0	0
PANK3	79646	broad.mit.edu	37	5	167988438	167988438	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:167988438T>C	uc003lzz.1	-	5	1196	c.896A>G	c.(895-897)AAT>AGT	p.N299S	uc003maa.1_5'Flank|MIR103-1_hsa-mir-103-1|MI0000109_5'Flank	NM_024594	NP_078870	Q9H999	PANK3_HUMAN	pantothenate kinase 3	299					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			ovary(1)	1	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		ACCAATGTTATTGGTGATAGT	0.323			NA											12	20					0	0	0.09319	0	0
FOXI1	2299	broad.mit.edu	37	5	169535488	169535488	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:169535488G>T	uc003mai.3	+	2	1055	c.1010G>T	c.(1009-1011)TGG>TTG	p.W337L	FOXI1_uc003maj.3_Missense_Mutation_p.W242L	NM_012188	NP_036320	Q12951	FOXI1_HUMAN	forkhead box I1 isoform a	337					epidermal cell fate specification|otic placode formation|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0267)|all_lung(126;0.04)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGGGTGACTGGGCGAACCCC	0.582			NA							Pendred_syndrome				34	80					2.19358e-23	2.87186e-23	0.225048	1	0
HRH2	3274	broad.mit.edu	37	5	175110362	175110362	+	Silent	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:175110362C>A	uc003mdd.2	+	1	1899	c.126C>A	c.(124-126)GCC>GCA	p.A42A	HRH2_uc003mdc.3_Silent_p.A42A	NM_022304	NP_071640	P25021	HRH2_HUMAN	histamine receptor H2 isoform 2	42	Helical; Name=1; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			ovary(1)	1	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	TCTGTCTGGCCGTGGGCTTGA	0.587			NA											60	148					1.02487e-32	1.36879e-32	0.139131	1	0
NSD1	64324	broad.mit.edu	37	5	176637018	176637018	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr5:176637018G>T	uc003mfr.3	+	5	1756	c.1618G>T	c.(1618-1620)GGG>TGG	p.G540W	NSD1_uc003mft.3_Missense_Mutation_p.G271W|NSD1_uc003mfs.1_Missense_Mutation_p.G437W|NSD1_uc011dfx.1_Missense_Mutation_p.G188W	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	540					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		CTTTATCTCTGGGGATATATC	0.438			NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			30	53					3.11337e-16	3.97155e-16	0.173368	1	0
EXOC2	55770	broad.mit.edu	37	6	549247	549247	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:549247T>A	uc003mtd.2	-	22	2300	c.2166A>T	c.(2164-2166)GAA>GAT	p.E722D	EXOC2_uc003mte.2_Missense_Mutation_p.E722D|EXOC2_uc011dho.1_Missense_Mutation_p.E317D	NM_018303	NP_060773	Q96KP1	EXOC2_HUMAN	Sec5 protein	722					exocytosis|protein transport					breast(4)|ovary(2)|pancreas(1)	7	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		AGGTGTGACGTTCTAGATAGC	0.383			NA											42	80					0	0	0.09836	0	0
ATXN1	6310	broad.mit.edu	37	6	16306818	16306818	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:16306818G>A	uc003nbt.2	-	9	3161	c.2190C>T	c.(2188-2190)ATC>ATT	p.I730I	ATXN1_uc010jpi.2_Silent_p.I730I|ATXN1_uc010jpj.1_RNA	NM_000332	NP_000323	P54253	ATX1_HUMAN	ataxin 1	730	Interaction with USP7.|RNA-binding.				cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			skin(3)|central_nervous_system(1)	4	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				TCCCCTGGTTGATTCCGTTTT	0.587			NA											5	95					0	0	0.184627	0	0
HLA-G	3135	broad.mit.edu	37	6	29797446	29797446	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:29797446C>T	uc003nnw.2	+	5	1049	c.871C>T	c.(871-873)CCG>TCG	p.P291S	HLA-G_uc011dmb.1_Missense_Mutation_p.P263S|HLA-G_uc003raj.3_Missense_Mutation_p.P296S|HLA-G_uc003nnz.3_Missense_Mutation_p.P199S|HLA-G_uc010jrn.2_Intron|HLA-G_uc003nny.3_RNA|HLA-G_uc003ran.1_5'Flank	NM_002127	NP_002118	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	291	Extracellular (Potential).|Ig-like C1-type.|Alpha-3.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			ovary(3)|central_nervous_system(1)	4						TGAGGGGCTGCCGGAGCCCCT	0.582			NA											7	24					0	0	0.038147	0	0
HLA-A	3105	broad.mit.edu	37	6	29910587	29910587	+	Nonsense_Mutation	SNP	G	G	T	rs41549014		TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:29910587G>T	uc003nol.2	+	2	127	c.127G>T	c.(127-129)GAG>TAG	p.E43*	HLA-G_uc011dmb.1_Intron|HCG4P6_uc003nog.1_Intron|HLA-A_uc010jrq.2_5'UTR|HLA-A_uc003nok.2_5'UTR|HLA-A_uc003non.2_Nonsense_Mutation_p.E43*|HLA-A_uc003noo.2_Nonsense_Mutation_p.E43*|HLA-A_uc010jrr.2_Nonsense_Mutation_p.E43*|HLA-A_uc003nom.2_5'UTR|HLA-A_uc010klp.2_Nonsense_Mutation_p.E15*|HLA-A_uc011dmc.1_5'UTR|HLA-A_uc011dmd.1_5'Flank	NM_002116	NP_002107	P30443	1A01_HUMAN	major histocompatibility complex, class I, A	43	Extracellular (Potential).|Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity			upper_aerodigestive_tract(1)|ovary(1)	2						CGGCCGCGGGGAGCCCCGCTT	0.706			NA							Melanoma_Familial_Clustering_of|Lichen_Sclerosis_et_Atrophicus_Familial_Clustering_of|Osteosarcoma_Familial_Clustering_of|Naso-/Oropharyngeal/Laryngeal_Cancer_Familial_Clustering_of	Multiple Myeloma(9;0.094)			3	13					1.23904e-05	1.36983e-05	0.184627	1	0
LY6G6F	259215	broad.mit.edu	37	6	31675858	31675858	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:31675858G>T	uc003nwa.1	+	3	593	c.593G>T	c.(592-594)AGA>ATA	p.R198I	BAT5_uc011dnz.1_Intron|LY6G6F_uc003nwb.1_Missense_Mutation_p.R198I	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	198	Extracellular (Potential).					integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						CGAAGACCAAGAATCATCCGC	0.542			NA											6	139					3.09899e-07	3.50397e-07	0.047766	1	0
SYNGAP1	8831	broad.mit.edu	37	6	33405994	33405994	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:33405994G>A	uc011dri.1	+	8	1507	c.1312G>A	c.(1312-1314)GCC>ACC	p.A438T	SYNGAP1_uc003oeo.1_Missense_Mutation_p.A423T|SYNGAP1_uc010juy.2_Missense_Mutation_p.A423T|SYNGAP1_uc010juz.2_Missense_Mutation_p.A150T	NM_006772	NP_006763	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	438					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			ovary(4)	4						CTTGGAGCCCGCCCTGAATGT	0.512			NA											94	169					0	0	0.139131	0	0
GPR126	57211	broad.mit.edu	37	6	142691435	142691435	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:142691435G>A	uc010khc.2	+	4	985	c.574G>A	c.(574-576)GTT>ATT	p.V192I	GPR126_uc010khd.2_Missense_Mutation_p.V192I|GPR126_uc010khe.2_Missense_Mutation_p.V192I|GPR126_uc010khf.2_Missense_Mutation_p.V192I|GPR126_uc003qix.2_Missense_Mutation_p.V192I	NM_020455	NP_065188	Q86SQ4	GP126_HUMAN	G protein-coupled receptor 126 alpha 1	192	Pentaxin.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		AGCAACCAAAGTTGGCCATGA	0.438			NA											10	8					0	0	0.09319	0	0
THSD7A	221981	broad.mit.edu	37	7	11486868	11486868	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:11486868C>T	uc003ssf.3	-	12	3041	c.2789G>A	c.(2788-2790)CGC>CAC	p.R930H		NM_015204	NP_056019	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	930	TSP type-1 9.|Extracellular (Potential).					integral to membrane				ovary(3)	3				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		AACAAGAGTGCGCTTTCTGGT	0.463			NA								HNSCC(18;0.044)			7	23					0	0	0.02938	0	0
HOXA10	3206	broad.mit.edu	37	7	27211592	27211592	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:27211592G>A	uc011jzm.1	-	2	1189	c.1159C>T	c.(1159-1161)CGC>TGC	p.R387C	MIR196B_hsa-mir-196b|MI0001150_5'Flank|HOXA10_uc003syw.3_Missense_Mutation_p.R71C	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	387	Homeobox.			R -> P (in Ref. 7; AAD14030/AAD14031).	spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTCATCCTGCGGTTCTGAAAC	0.478			NA											5	53					0	0	0.184627	0	0
DPY19L1	23333	broad.mit.edu	37	7	34989430	34989430	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:34989430C>T	uc003tem.3	-	14	1327	c.1182G>A	c.(1180-1182)GAG>GAA	p.E394E		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	394						integral to membrane					0						TAAAGTCAAACTCCGCTGCAC	0.338			NA											7	28					0	0	0.047766	0	0
AMPH	273	broad.mit.edu	37	7	38431514	38431514	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:38431514G>A	uc003tgu.2	-	19	1782	c.1713C>T	c.(1711-1713)GAC>GAT	p.D571D	AMPH_uc003tgv.2_Silent_p.D529D|AMPH_uc003tgt.2_Silent_p.D456D|AMPH_uc003tgw.1_Silent_p.D594D|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	571					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						GAGGAGCCGCGTCCTCGGTGG	0.607			NA											14	29					0	0	0.146539	0	0
CACNA2D1	781	broad.mit.edu	37	7	81634739	81634739	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:81634739C>A	uc003uhr.1	-	18	1846	c.1590G>T	c.(1588-1590)AAG>AAT	p.K530N		NM_000722	NP_000713	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha	530	Extracellular (Potential).|Cache.					voltage-gated calcium channel complex	metal ion binding			ovary(5)|pancreas(1)	6					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	ATATACTGACCTTTGGCTGAA	0.289			NA											6	15					8.12818e-05	8.64978e-05	0.02938	1	0
ASNS	440	broad.mit.edu	37	7	97481608	97481608	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:97481608C>A	uc003uot.3	-	13	2155	c.1649G>T	c.(1648-1650)CGC>CTC	p.R550L	ASNS_uc011kin.1_Missense_Mutation_p.R467L|ASNS_uc003uou.3_Missense_Mutation_p.R550L|ASNS_uc003uov.3_Missense_Mutation_p.R550L|ASNS_uc011kio.1_Missense_Mutation_p.R529L|ASNS_uc003uow.3_Missense_Mutation_p.R529L|ASNS_uc003uox.3_Missense_Mutation_p.R467L	NM_133436	NP_597680	P08243	ASNS_HUMAN	asparagine synthetase	550					cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGTCAGCGTGCGGGCAGAAGG	0.512	Melanoma(70;6 1280 3108 3799 51123)|GBM(6;275 291 425 9929 27738)		NA											11	51					2.80697e-09	3.22883e-09	0.080935	1	0
EPO	2056	broad.mit.edu	37	7	100319326	100319326	+	Silent	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:100319326G>A	uc003uwi.2	+	2	340	c.159G>A	c.(157-159)ACG>ACA	p.T53T	EPO_uc011kkc.1_Silent_p.T53T	NM_000799	NP_000790	P01588	EPO_HUMAN	erythropoietin precursor	53					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)	2	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	AGAATATCACGGTGAGACCCC	0.612			NA											7	29					0	0	0.038147	0	0
TAS2R16	50833	broad.mit.edu	37	7	122634844	122634844	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:122634844G>T	uc003vkl.1	-	1	911	c.845C>A	c.(844-846)ACG>AAG	p.T282K		NM_016945	NP_058641	Q9NYV7	T2R16_HUMAN	taste receptor T2R16	282	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			ovary(1)|skin(1)	2						CCTTTTCAACGTAGGGCTGCT	0.423			NA											44	81					1.63429e-32	2.16816e-32	0.139131	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	Colon(40;35 892 2973 5743 27438)	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				24	53					0	0	0.134883	0	0
BRAF	673	broad.mit.edu	37	7	140534477	140534477	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr7:140534477G>A	uc003vwc.3	-	3	497	c.436C>T	c.(436-438)CGG>TGG	p.R146W		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	146					activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding		KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GGGTTGCTCCGTGCCACATCT	0.438	Colon(40;35 892 2973 5743 27438)		61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				26	61					0	0	0.108266	0	0
XKR5	389610	broad.mit.edu	37	8	6682698	6682698	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr8:6682698T>A	uc003wqp.2	-	3	438	c.416A>T	c.(415-417)GAT>GTT	p.D139V	XKR5_uc003wqq.2_5'UTR|XKR5_uc003wqr.1_RNA	NM_207411	NP_997294	Q6UX68	XKR5_HUMAN	XK-related protein 5a	139						integral to membrane					0			STAD - Stomach adenocarcinoma(24;0.0984)	READ - Rectum adenocarcinoma(644;0.137)|COAD - Colon adenocarcinoma(149;0.166)		TGGCACAATATCTGTGAAGTC	0.557			NA											9	21					0	0	0.09319	0	0
PRKDC	5591	broad.mit.edu	37	8	48801713	48801713	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr8:48801713C>A	uc003xqi.2	-	34	4199	c.4142G>T	c.(4141-4143)AGC>ATC	p.S1381I	PRKDC_uc003xqj.2_Missense_Mutation_p.S1381I|PRKDC_uc011ldh.1_Intron	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	1381					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				GAAACCTATGCTTGCGGGCTC	0.443	Esophageal Squamous(79;1091 1253 12329 31680 40677)		NA						NHEJ					13	29					6.72482e-11	7.96571e-11	0.132662	1	0
NCOA2	10499	broad.mit.edu	37	8	71075726	71075726	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr8:71075726C>T	uc003xyn.1	-	8	968	c.806G>A	c.(805-807)AGT>AAT	p.S269N		NM_006540	NP_006531	Q15596	NCOA2_HUMAN	nuclear receptor coactivator 2	269					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	histone acetyltransferase activity|ligand-dependent nuclear receptor binding|nuclear hormone receptor binding|signal transducer activity		PAX3/NCOA2(4)	lung(6)|soft_tissue(4)|breast(2)|skin(2)|ovary(1)|pancreas(1)	16	Breast(64;0.201)		Epithelial(68;0.0147)|OV - Ovarian serous cystadenocarcinoma(28;0.0455)|all cancers(69;0.0606)			AGTAGTAAAACTTTCTGATGA	0.393			NA	T	RUNXBP2	AML								17	31					0	0	0.175082	0	0
SLC25A32	81034	broad.mit.edu	37	8	104419926	104419926	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr8:104419926G>A	uc003yll.2	-	2	544	c.241C>T	c.(241-243)CTT>TTT	p.L81F	SLC25A32_uc011lhr.1_5'UTR	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	81	Solcar 1.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	CCTTGATAAAGTCCCCGTAGT	0.388			NA											55	77					0	0	0.139131	0	0
COL22A1	169044	broad.mit.edu	37	8	139606389	139606389	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr8:139606389G>C	uc003yvd.2	-	63	4933	c.4486C>G	c.(4486-4488)CAA>GAA	p.Q1496E	COL22A1_uc011ljo.1_Missense_Mutation_p.Q776E	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1496	Pro-rich.|Gly-rich.|Collagen-like 15.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGTCTGCCTTGAGATGACTTC	0.617			NA								HNSCC(7;0.00092)			3	40					0	0	0.115264	0	0
IFNA16	3449	broad.mit.edu	37	9	21216973	21216973	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr9:21216973T>C	uc003zor.1	-	1	338	c.332A>G	c.(331-333)GAA>GGA	p.E111G	IFNA14_uc003zoo.1_Intron	NM_002173	NP_002164	P05015	IFN16_HUMAN	interferon, alpha 16 precursor	111					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			skin(1)	1				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		CTGGAAAAGTTCAATGTAGAA	0.488			NA											36	200					0	0	0.193644	0	0
ABCA1	19	broad.mit.edu	37	9	107562812	107562812	+	Silent	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr9:107562812C>T	uc004bcl.2	-	35	5065	c.4752G>A	c.(4750-4752)CTG>CTA	p.L1584L		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1584	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTTGGTGTCCAGTCCTGTCA	0.393			NA											9	107					0	0	0.069234	0	0
ZBTB34	403341	broad.mit.edu	37	9	129642655	129642655	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr9:129642655A>G	uc004bqm.3	+	2	1062	c.965A>G	c.(964-966)CAG>CGG	p.Q322R		NM_001099270	NP_001092740	Q8NCN2	ZBT34_HUMAN	zinc finger and BTB domain containing 34	322					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CGTGCCCGCCAGAAGCGGGCT	0.567			NA											11	21					0	0	0.080935	0	0
MXRA5	25878	broad.mit.edu	37	X	3235828	3235828	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chrX:3235828C>G	uc004crg.3	-	6	6051	c.5894G>C	c.(5893-5895)GGA>GCA	p.G1965A		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1965	Ig-like C2-type 4.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AATGGTGTCTCCCAGGTAGAC	0.582			NA											4	20					0	0	0.184627	0	0
RGAG4	340526	broad.mit.edu	37	X	71350580	71350580	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chrX:71350580G>A	uc010nlh.1	-	1	1172	c.811C>T	c.(811-813)CGC>TGC	p.R271C	NHSL2_uc011mqa.1_Intron|RGAG4_uc004eaj.1_RNA|NHSL2_uc004eak.1_5'Flank	NM_001024455	NP_001019626	Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	271										ovary(2)|skin(1)	3	Renal(35;0.156)					TTTTGGAGGCGGCAGTCATCC	0.507			NA											13	66					0	0	0.11911	0	0
GPR174	84636	broad.mit.edu	37	X	78427044	78427044	+	Silent	SNP	C	C	G			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chrX:78427044C>G	uc004edg.1	+	1	576	c.540C>G	c.(538-540)GCC>GCG	p.A180A		NM_032553	NP_115942	Q9BXC1	GP174_HUMAN	putative purinergic receptor FKSG79	180	Extracellular (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(1)|central_nervous_system(1)	2						TCAACCTGGCCCAGTCCGTTG	0.463			NA								HNSCC(63;0.18)			35	28					0	0	0.203993	0	0
PCDH11X	27328	broad.mit.edu	37	X	91134202	91134202	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chrX:91134202C>T	uc004efk.1	+	2	3808	c.2963C>T	c.(2962-2964)CCC>CTC	p.P988L	PCDH11X_uc004efl.1_Missense_Mutation_p.P988L|PCDH11X_uc004efo.1_Missense_Mutation_p.P988L|PCDH11X_uc010nmv.1_Missense_Mutation_p.P988L|PCDH11X_uc004efm.1_Missense_Mutation_p.P988L|PCDH11X_uc004efn.1_Missense_Mutation_p.P988L|PCDH11X_uc004efh.1_Missense_Mutation_p.P988L|PCDH11X_uc004efj.1_Missense_Mutation_p.P988L	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	988	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						AGTTCAGATCCCTACAGCGTT	0.498	NSCLC(38;925 1092 2571 38200 45895)		NA											62	57					0	0	0.139131	0	0
JTB	10899	broad.mit.edu	37	1	153949696	153949711	+	Frame_Shift_Del	DEL	GGGGAGGCCAGGCCTC	GGGGAGGCCAGGCCTC	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	GGGGAGGCCAGGCCTC	GGGGAGGCCAGGCCTC	-	-	GGGGAGGCCAGGCCTC	GGGGAGGCCAGGCCTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:153949696_153949711delGGGGAGGCCAGGCCTC	uc001fds.2	-	1	741_756	c.18_33delGAGGCCTGGCCTCCCC	c.(16-33)GGGAGGCCTGGCCTCCCCfs	p.G6fs		NM_006694	NP_006685	O76095	JTB_HUMAN	jumping translocation breakpoint precursor	6_11					apoptosis|cell cycle cytokinesis|mitosis|positive regulation of protein kinase activity	integral to plasma membrane|membrane fraction|microtubule organizing center|midbody|mitochondrion|spindle	protein kinase binding				0	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCGGCCCTGGGGGAGGCCAGGCCTCCCGGCACCCG	0.639			NA											8	92	---	---	---	---	NA	NA	NA	NA	NA
MARK1	4139	broad.mit.edu	37	1	220791735	220791736	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr1:220791735_220791736insT	uc001hmn.3	+	8	1233_1234	c.636_637insT	c.(634-639)AAATTGfs	p.K212fs	MARK1_uc009xdw.2_Frame_Shift_Ins_p.K212fs|MARK1_uc010pun.1_Frame_Shift_Ins_p.K212fs|MARK1_uc001hmm.3_Frame_Shift_Ins_p.K190fs	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	212_213	Protein kinase.				intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		TTGGGAACAAATTGGACACATT	0.411			NA											38	35	---	---	---	---	NA	NA	NA	NA	NA
C14orf4	64207	broad.mit.edu	37	14	77493792	77493794	+	In_Frame_Del	DEL	TGT	TGT	-	rs28718623		TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	TGT	TGT	-	-	TGT	TGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr14:77493792_77493794delTGT	uc001xsy.2	-	1	1241_1243	c.342_344delACA	c.(340-345)CAACAG>CAG	p.114_115QQ>Q		NM_024496	NP_078772	Q9H1B7	I2BPL_HUMAN	chromosome 14 open reading frame 4	114_115	Poly-Gln.|Potential.					nucleus					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.00347)|KIRC - Kidney renal clear cell carcinoma(182;0.0878)		ctgctgctgctgttgctgctgct	0.266			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
MGRN1	23295	broad.mit.edu	37	16	4727498	4727500	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	GAA	GAA	-	-	GAA	GAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr16:4727498_4727500delGAA	uc002cwz.2	+	11	1126_1128	c.990_992delGAA	c.(988-993)CGGAAG>CGG	p.K332del	MGRN1_uc002cxa.2_In_Frame_Del_p.K332del|MGRN1_uc010btx.2_In_Frame_Del_p.K333del|MGRN1_uc010btw.2_In_Frame_Del_p.K333del|MGRN1_uc002cxb.2_In_Frame_Del_p.K371del|MGRN1_uc010uxo.1_In_Frame_Del_p.K332del|MGRN1_uc010uxp.1_In_Frame_Del_p.K332del|MGRN1_uc010uxq.1_Intron	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	332					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						GGGCGGTGCGGAAGAAGCCAGGA	0.685			NA											15	38	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579583	7579583	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr17:7579583delA	uc002gim.2	-	4	298	c.104delT	c.(103-105)TTGfs	p.L35fs	TP53_uc002gig.1_Frame_Shift_Del_p.L35fs|TP53_uc002gih.2_Frame_Shift_Del_p.L35fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.L35fs|TP53_uc010cni.1_Frame_Shift_Del_p.L35fs|TP53_uc002gij.2_Frame_Shift_Del_p.L35fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_5'UTR|TP53_uc010cnk.1_Frame_Shift_Del_p.L50fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	35	Transcription activation (acidic).|Interaction with HRMT1L2.		L -> F (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.L35F(3)|p.L35fs*9(2)|p.L35fs*8(1)|p.?(1)|p.S33fs*23(1)|p.P13fs*18(1)|p.S33fs*6(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTGGGACGGCAAGGGGGACTG	0.388	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			73	107	---	---	---	---	NA	NA	NA	NA	NA
SETBP1	26040	broad.mit.edu	37	18	42531549	42531549	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr18:42531549delC	uc010dni.2	+	4	2540	c.2244delC	c.(2242-2244)CACfs	p.H748fs		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	748						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CCATCAAGCACCCCAGGCCTG	0.562			NA							Schinzel-Giedion_syndrome				21	57	---	---	---	---	NA	NA	NA	NA	NA
DSEL	92126	broad.mit.edu	37	18	65180619	65180619	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr18:65180619delT	uc002lke.1	-	2	2481	c.1257delA	c.(1255-1257)ATAfs	p.I419fs		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	409						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GGAATGTGTGTATTTTTGCAG	0.488			NA											23	36	---	---	---	---	NA	NA	NA	NA	NA
SGOL2	151246	broad.mit.edu	37	2	201434609	201434609	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr2:201434609delC	uc002uvw.2	+	6	810	c.697delC	c.(697-699)CCCfs	p.P233fs	SGOL2_uc002uvv.3_Frame_Shift_Del_p.P233fs|SGOL2_uc010zhd.1_Frame_Shift_Del_p.P233fs|SGOL2_uc010zhe.1_Frame_Shift_Del_p.P233fs	NM_152524	NP_689737	Q562F6	SGOL2_HUMAN	shugoshin-like 2 isoform 1	233					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			ovary(2)|skin(2)	4						TGATGTACCTCCCAGAGGTGA	0.289			NA											19	59	---	---	---	---	NA	NA	NA	NA	NA
FAM175A	84142	broad.mit.edu	37	4	84393370	84393390	+	Splice_Site	DEL	AATACCTTTTTGACATTTGAT	AATACCTTTTTGACATTTGAT	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	AATACCTTTTTGACATTTGAT	AATACCTTTTTGACATTTGAT	-	-	AATACCTTTTTGACATTTGAT	AATACCTTTTTGACATTTGAT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr4:84393370_84393390delAATACCTTTTTGACATTTGAT	uc003hou.2	-	4	347	c.282_splice	c.e4+1	p.K94_splice	FAM175A_uc003hot.2_5'Flank|FAM175A_uc003hov.2_Intron	NM_139076	NP_620775	Q6UWZ7	F175A_HUMAN	coiled-coil domain containing 98						chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|response to ionizing radiation	BRCA1-A complex	polyubiquitin binding			kidney(1)	1						TAAATTAGAGAATACCTTTTTGACATTTGATAATATTTTCT	0.276			NA											3	6	---	---	---	---	NA	NA	NA	NA	NA
PRPF4B	8899	broad.mit.edu	37	6	4032674	4032674	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr6:4032674delG	uc003mvv.2	+	2	1014	c.923delG	c.(922-924)CGGfs	p.R308fs	PRPF4B_uc011dhv.1_RNA	NM_003913	NP_003904	Q13523	PRP4B_HUMAN	serine/threonine-protein kinase PRP4K	308	Arg/Lys-rich (basic).					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(5)	5	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				AGAAGGTCACGGTCCAAAGAG	0.368			NA											17	52	---	---	---	---	NA	NA	NA	NA	NA
BAT2L1	84726	broad.mit.edu	37	9	134353948	134353948	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7903-01A-11D-2167-08	TCGA-55-7903-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d4b2ade8-2d2e-4e63-8cde-bcdb7e28e8b1	b4cf6e53-f5cd-433e-9571-98dca4a35bf3	g.chr9:134353948delC	uc004can.3	+	17	4755	c.4700delC	c.(4699-4701)ACCfs	p.T1567fs	BAT2L1_uc004cao.3_Frame_Shift_Del_p.T925fs	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	1567	Potential.						protein binding				0						GAAGTCCTGACCAAGAAGCAG	0.617			NA									OREG0019562	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	89	---	---	---	---	NA	NA	NA	NA	NA