Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCNH1	3756	broad.mit.edu	37	1	211092987	211092987	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr1:211092987A>G	uc001hib.2	-	7	1627	c.1457T>C	c.(1456-1458)ATT>ACT	p.I486T	KCNH1_uc001hic.2_Missense_Mutation_p.I459T	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	486	Helical; Name=Segment S6; (Potential).				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CTTACAGCCAATCATCATGAT	0.493			NA											6	145					0	0	0.02938	0	0
KIAA0913	23053	broad.mit.edu	37	10	75550013	75550013	+	Silent	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr10:75550013C>T	uc009xrl.2	+	7	936	c.904C>T	c.(904-906)CTG>TTG	p.L302L	KIAA0913_uc001jve.2_Silent_p.L302L|KIAA0913_uc001jvf.2_Silent_p.L302L|KIAA0913_uc001jvh.2_5'Flank|KIAA0913_uc001jvi.2_5'Flank|KIAA0913_uc010qkr.1_5'Flank|KIAA0913_uc001jvj.2_5'Flank	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	302							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					CAAAAAGACACTGCACAAGTT	0.552			NA											8	104					0	0	0.038147	0	0
OR5I1	10798	broad.mit.edu	37	11	55703528	55703528	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr11:55703528G>T	uc010ris.1	-	1	349	c.349C>A	c.(349-351)CTG>ATG	p.L117M		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGGCGGCCAGGATGAAGGAT	0.443			NA											11	36					2.80697e-09	3.43075e-09	0.080935	1	0
FAT3	120114	broad.mit.edu	37	11	92616397	92616397	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr11:92616397G>A	uc001pdj.3	+	23	12792	c.12775G>A	c.(12775-12777)GAG>AAG	p.E4259K	FAT3_uc001pdi.3_Missense_Mutation_p.E699K	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4259	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCTGGGAGGCGAGCACCAGGA	0.682			NA								TCGA Ovarian(4;0.039)			17	116					0	0	0.038395	0	0
Unknown	0	broad.mit.edu	37	12	92105	92105	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr12:92105G>A	uc010sdi.1	-	2	233	c.205C>T	c.(205-207)CGC>TGC	p.R69C	uc010sdj.1_RNA					SubName: Full=DEAD/H box polypeptide 11 like 11;												NA						AAGGAAGGGCGCAGCGCCAGG	0.592			NA											3	10					0	0	0.009096	0	0
METT11D1	64745	broad.mit.edu	37	14	21464765	21464765	+	Missense_Mutation	SNP	G	G	A	rs144273829		TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr14:21464765G>A	uc001vyn.2	+	13	1357	c.1160G>A	c.(1159-1161)CGT>CAT	p.R387H	METT11D1_uc001vym.2_Missense_Mutation_p.R387H|METT11D1_uc001vyo.2_Missense_Mutation_p.R387H|METT11D1_uc001vyp.2_Missense_Mutation_p.R229H|METT11D1_uc001vyq.2_Missense_Mutation_p.R229H|SLC39A2_uc001vyr.2_5'Flank|SLC39A2_uc001vys.2_5'Flank	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform	387					translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CGCTGGCCCCGTATCACTCAG	0.537			NA											8	48					0	0	0.047766	0	0
AHNAK2	113146	broad.mit.edu	37	14	105413949	105413949	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr14:105413949G>A	uc010axc.1	-	7	7959	c.7839C>T	c.(7837-7839)AGC>AGT	p.S2613S	AHNAK2_uc001ypx.2_Silent_p.S2513S	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2613						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCACCTCCATGCTGGACAGAG	0.632			NA											36	191					0	0	0.074837	0	0
RYR3	6263	broad.mit.edu	37	15	33765678	33765678	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr15:33765678G>A	uc001zhi.2	+	2	180	c.110G>A	c.(109-111)TGC>TAC	p.C37Y	RYR3_uc010bar.2_Missense_Mutation_p.C37Y	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	37	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGGAAGTTCTGCCTGGCAGCC	0.547			NA											9	55					0	0	0.080935	0	0
LCMT1	51451	broad.mit.edu	37	16	25175976	25175976	+	Silent	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr16:25175976C>T	uc002dnx.1	+	7	785	c.627C>T	c.(625-627)TCC>TCT	p.S209S	LCMT1_uc002dny.1_Silent_p.S154S|LCMT1_uc002dnz.1_Silent_p.S109S|LCMT1_uc002doa.1_Silent_p.S54S	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a	209							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	CAGAGCAGTCCGCAAACCTCC	0.428	Colon(200;565 2072 24396 47922 50898)		NA											12	87					0	0	0.080935	0	0
TTN	7273	broad.mit.edu	37	2	179600640	179600640	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr2:179600640C>T	uc010zfg.1	-	47	11025	c.10801G>A	c.(10801-10803)GAC>AAC	p.D3601N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.D262N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4528							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCTGCGTCGGAAATCCTC	0.438			NA											10	73					0	0	0.09319	0	0
LRRN4	164312	broad.mit.edu	37	20	6022727	6022727	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr20:6022727G>A	uc002wmo.2	-	5	1388	c.1164C>T	c.(1162-1164)ACC>ACT	p.T388T		NM_152611	NP_689824	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4 precursor	388	Extracellular (Potential).					integral to membrane				skin(3)	3						TGGGCGCGACGGTGGTACCCT	0.677			NA											7	39					0	0	0.058154	0	0
PAK7	57144	broad.mit.edu	37	20	9546621	9546621	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr20:9546621G>A	uc002wnl.2	-	6	1946	c.1401C>T	c.(1399-1401)ACC>ACT	p.T467T	PAK7_uc002wnk.2_Silent_p.T467T|PAK7_uc002wnj.2_Silent_p.T467T|PAK7_uc010gby.1_Silent_p.T467T	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	467	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			TGTGTTTCTCGGTGGCGATGC	0.522			NA											17	165					0	0	0.0333	0	0
ARPP21	10777	broad.mit.edu	37	3	35785377	35785377	+	Missense_Mutation	SNP	C	C	T	rs139862817	byFrequency	TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr3:35785377C>T	uc003cgb.2	+	18	2216	c.1952C>T	c.(1951-1953)ACG>ATG	p.T651M	ARPP21_uc003cga.2_Missense_Mutation_p.T632M|ARPP21_uc011axy.1_Missense_Mutation_p.T652M|ARPP21_uc003cgf.2_Missense_Mutation_p.T487M|ARPP21_uc003cgg.2_Missense_Mutation_p.T174M|uc011axz.1_5'Flank|MIR128-2_hsa-mir-128-2|MI0000727_5'Flank	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	651	Gln-rich.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						ACCTCAACCACGCAACAGTAC	0.478			NA											9	110					0	0	0.058154	0	0
EPHA3	2042	broad.mit.edu	37	3	89456471	89456471	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr3:89456471G>A	uc003dqy.2	+	8	1872	c.1647G>A	c.(1645-1647)GCG>GCA	p.A549A	EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	549	Helical; (Potential).					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CCATTTCAGCGGCAGTAGCAA	0.398			NA								TSP Lung(6;0.00050)			3	51					0	0	0.004672	0	0
UNC5C	8633	broad.mit.edu	37	4	96163597	96163597	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr4:96163597T>A	uc003htp.1	-	7	1245	c.1091A>T	c.(1090-1092)GAT>GTT	p.D364V	UNC5C_uc010ilc.1_Missense_Mutation_p.D364V|UNC5C_uc003htq.2_Missense_Mutation_p.D364V	NM_003728	NP_003719	O95185	UNC5C_HUMAN	unc5C precursor	364	Extracellular (Potential).|TSP type-1 2.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			ovary(3)|pancreas(1)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GCAAAGCCCATCAGTGCAGTT	0.512			NA											6	36					0	0	0.021553	0	0
NPC1L1	29881	broad.mit.edu	37	7	44579720	44579720	+	Silent	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr7:44579720G>A	uc003tlb.2	-	2	332	c.276C>T	c.(274-276)TCC>TCT	p.S92S	NPC1L1_uc003tlc.2_Silent_p.S92S|NPC1L1_uc011kbw.1_Silent_p.S92S|NPC1L1_uc003tld.2_Silent_p.S92S	NM_013389	NP_037521	Q9UHC9	NPCL1_HUMAN	Niemann-Pick C1-like protein 1 isoform 1	92	Extracellular (Potential).				cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5					Ezetimibe(DB00973)	GCTGCTTGGCGGAGCAGCAGG	0.602			NA											3	35					0	0	0.004672	0	0
REXO1L1	254958	broad.mit.edu	37	8	86573798	86573798	+	Silent	SNP	T	T	G			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr8:86573798T>G	uc011lfw.1	-	1	1471	c.1425A>C	c.(1423-1425)GCA>GCC	p.A475A		NM_172239	NP_758439	Q8IX06	GOR_HUMAN	exonuclease GOR	643						cytoplasm|nucleus	exonuclease activity|nucleic acid binding				0						GGCAGGCGCTTGCGTCCTCGC	0.667			NA											3	67					0	0	0.009096	0	0
HCFC1	3054	broad.mit.edu	37	X	153228790	153228790	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chrX:153228790G>A	uc004fjp.2	-	4	1126	c.598C>T	c.(598-600)CGG>TGG	p.R200W		NM_005334	NP_005325	P51610	HCFC1_HUMAN	host cell factor 1	200				R->D: Eliminates VIC formation. Unable to rescue proliferation in temperature- sensitive arrested cells.	cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)	2	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGTGACTCCCGGGGTGGTGGT	0.552			NA											24	89					0	0	0.0918	0	0
F8	2157	broad.mit.edu	37	X	154088755	154088755	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chrX:154088755A>T	uc004fmt.2	-	25	7023	c.6852T>A	c.(6850-6852)AGT>AGA	p.S2284R	F8_uc004fms.2_Missense_Mutation_p.S149R	NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	2284	F5/8 type C 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGCCATCTTGACTGCTGGAGA	0.393			NA											23	263					0	0	0.083992	0	0
PDZK1IP1	10158	broad.mit.edu	37	1	47649678	47649678	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr1:47649678delC	uc001cqw.2	-	4	477	c.310delG	c.(310-312)GAGfs	p.E104fs		NM_005764	NP_005755	Q13113	PDZ1I_HUMAN	PDZK1 interacting protein 1	104						integral to membrane					0						CCTTCCTCCTCGGGCACATTC	0.572			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
GDF7	151449	broad.mit.edu	37	2	20867303	20867303	+	Frame_Shift_Del	DEL	A	A	-			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr2:20867303delA	uc002rdz.1	+	1	880	c.304delA	c.(304-306)AGGfs	p.R102fs		NM_182828	NP_878248	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7 preproprotein	102					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTGGCCGGGAGGGCTCCGGC	0.577			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
KCNN2	3781	broad.mit.edu	37	5	113699634	113699634	+	Frame_Shift_Del	DEL	T	T	-			TCGA-75-6203-01A-11D-1753-08	TCGA-75-6203-10A-01D-1753-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d9cd7f95-07d3-4b87-be83-87340b08d249	fdf9b270-14ff-4961-978e-5dff14d77feb	g.chr5:113699634delT	uc003kqo.2	+	2	975	c.518delT	c.(517-519)CTTfs	p.L173fs		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	173	Helical; Name=Segment S2; (Potential).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGAAATGCCTTATCAGTCTC	0.483			NA											10	92	---	---	---	---	NA	NA	NA	NA	NA