Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TAS1R3	83756	broad.mit.edu	37	1	1268436	1268436	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr1:1268436G>C	uc010nyk.1	+	4	1411	c.1411G>C	c.(1411-1413)GTG>CTG	p.V471L		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	471	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	GCTCCACGACGTGGGCAGGTT	0.662			NA											9	38					0	0	0.004482	0	0
DFFA	1676	broad.mit.edu	37	1	10523219	10523219	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr1:10523219T>C	uc001arj.2	-	5	777	c.679A>G	c.(679-681)ATC>GTC	p.I227V	DFFA_uc001ark.2_Missense_Mutation_p.I227V	NM_004401	NP_004392	O00273	DFFA_HUMAN	DNA fragmentation factor, 45kDa, alpha	227					DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction|negative regulation of apoptosis	cytosol|mitochondrion|nucleoplasm|plasma membrane	deoxyribonuclease activity|identical protein binding				0	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.25e-07)|COAD - Colon adenocarcinoma(227;7.25e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000296)|Kidney(185;0.00074)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0487)		TCTCTGCTGATACCCGTGTCT	0.552			NA											15	25					0	0	0.003163	0	0
MACF1	23499	broad.mit.edu	37	1	39853047	39853047	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr1:39853047C>T	uc010oiu.1	+	22	9984	c.9853C>T	c.(9853-9855)CAA>TAA	p.Q3285*	MACF1_uc010ois.1_Nonsense_Mutation_p.Q2783*|MACF1_uc001cda.1_Nonsense_Mutation_p.Q2670*|MACF1_uc001cdc.1_Nonsense_Mutation_p.Q1849*	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4850	Spectrin 4.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AAGTCTTAATCAACACAGTGG	0.433			NA											15	144					0	0	0.004007	0	0
MIA3	375056	broad.mit.edu	37	1	222802129	222802129	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr1:222802129G>A	uc001hnl.2	+	4	1576	c.1567G>A	c.(1567-1569)GAT>AAT	p.D523N	MIA3_uc009xea.1_Missense_Mutation_p.D359N	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	523	Potential.|Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		AGCTTATGATGATACAGAAAA	0.423			NA											16	153					0	0	0.004007	0	0
OBSCN	84033	broad.mit.edu	37	1	228471293	228471293	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr1:228471293G>A	uc009xez.1	+	33	8871	c.8827G>A	c.(8827-8829)GCG>ACG	p.A2943T	OBSCN_uc001hsn.2_Missense_Mutation_p.A2943T|OBSCN_uc001hsp.1_Missense_Mutation_p.A642T|OBSCN_uc001hsq.1_Missense_Mutation_p.A199T	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	2943	Ig-like 29.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGAGCACCCCGCGGCCACAGT	0.632			NA											6	38					0	0	0.021553	0	0
SLIT1	6585	broad.mit.edu	37	10	98770874	98770874	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr10:98770874G>T	uc001kmw.2	-	31	3469	c.3217C>A	c.(3217-3219)CCA>ACA	p.P1073T		NM_003061	NP_003052	O75093	SLIT1_HUMAN	slit homolog 1 precursor	1073	EGF-like 4.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			ovary(4)	4		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GCATAACCTGGCATGCACTCA	0.612			NA											14	23					4.36969e-10	4.68749e-10	0.016723	1	0
DMBT1	1755	broad.mit.edu	37	10	124399750	124399750	+	Silent	SNP	T	T	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr10:124399750T>C	uc001lgk.1	+	52	6856	c.6750T>C	c.(6748-6750)TAT>TAC	p.Y2250Y	DMBT1_uc001lgl.1_Silent_p.Y2240Y|DMBT1_uc001lgm.1_Silent_p.Y1622Y|DMBT1_uc009xzz.1_Silent_p.Y2249Y|DMBT1_uc010qtx.1_Silent_p.Y970Y|DMBT1_uc009yab.1_Silent_p.Y953Y|DMBT1_uc009yac.1_Silent_p.Y544Y	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2250	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AAGTCCAGTATGGCAATTTTG	0.473	Ovarian(182;93 2026 18125 22222 38972)		NA											58	84					0	0	0.01441	0	0
MYO7A	4647	broad.mit.edu	37	11	76905531	76905531	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr11:76905531G>C	uc001oyb.2	+	32	4557	c.4285G>C	c.(4285-4287)GAG>CAG	p.E1429Q	MYO7A_uc010rsm.1_Missense_Mutation_p.E1418Q|MYO7A_uc001oyc.2_Missense_Mutation_p.E1429Q|MYO7A_uc009yus.1_RNA|MYO7A_uc009yut.1_Missense_Mutation_p.E640Q	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1429	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GAAGACGCTGGAGAAGTGGGC	0.592			NA											4	13					0	0	0.009096	0	0
FAT3	120114	broad.mit.edu	37	11	92523337	92523337	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr11:92523337G>A	uc001pdj.3	+	7	4581	c.4564G>A	c.(4564-4566)GAG>AAG	p.E1522K		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1522	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTATACTGCCGAGAGGCTGGA	0.498			NA								TCGA Ovarian(4;0.039)			14	134					0	0	0.016723	0	0
SMUG1	23583	broad.mit.edu	37	12	54576152	54576152	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr12:54576152C>T	uc001sff.1	-	4	670	c.541G>A	c.(541-543)GAG>AAG	p.E181K	SMUG1_uc001sfa.1_RNA|SMUG1_uc001sfe.1_3'UTR|SMUG1_uc001sfg.1_Missense_Mutation_p.E181K|SMUG1_uc009znf.1_Missense_Mutation_p.E181K|SMUG1_uc001sfb.3_Intron|SMUG1_uc001sfc.3_Intron|SMUG1_uc001sfd.3_Intron	NM_014311	NP_055126	Q53HV7	SMUG1_HUMAN	single-strand-selective monofunctional	181	DNA binding (By similarity).				depyrimidination	nucleolus|nucleoplasm	DNA binding|protein binding|single-strand selective uracil DNA N-glycosylase activity				0						GCAGGCAGCTCAGCAGGAGTA	0.602			NA						BER_DNA_glycosylases					11	86					0	0	0.010729	0	0
ANKLE2	23141	broad.mit.edu	37	12	133311158	133311158	+	Silent	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr12:133311158C>T	uc001ukx.2	-	10	1771	c.1704G>A	c.(1702-1704)GAG>GAA	p.E568E	ANKLE2_uc009zyw.1_5'UTR|ANKLE2_uc001uky.3_Silent_p.E506E	NM_015114	NP_055929	Q86XL3	ANKL2_HUMAN	ankyrin repeat and LEM domain containing 2	568						cytoplasm|integral to membrane|nuclear envelope					0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.3e-08)|Epithelial(86;1.56e-07)|all cancers(50;4.94e-06)		CATGAGCTAGCTCCCTGTAAG	0.423			NA											65	159					0	0	0.01441	0	0
SERPINA13	388007	broad.mit.edu	37	14	95108198	95108198	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr14:95108198G>A	uc001ydt.2	+	2	803	c.715G>A	c.(715-717)GAA>AAA	p.E239K		NR_015340				RecName: Full=Serpin A13; Flags: Precursor;											lung(1)|skin(1)	2						CCTCGGCAGTGAAACCACAGC	0.562			NA											19	98					0	0	0.012319	0	0
CCNK	8812	broad.mit.edu	37	14	99969230	99969230	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr14:99969230C>T	uc001ygi.3	+	8	1050	c.920C>T	c.(919-921)CCC>CTC	p.P307L	CCNK_uc001ygg.3_Splice_Site_p.D306_splice	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	307					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				CAGAAGGACCCCCAGCAACCA	0.622			NA											13	89					0	0	0.016723	0	0
DENND4A	10260	broad.mit.edu	37	15	65959865	65959865	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr15:65959865C>T	uc002aph.2	-	28	5409	c.5031G>A	c.(5029-5031)TGG>TGA	p.W1677*	DENND4A_uc002api.2_Nonsense_Mutation_p.W1720*	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1677					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GTCTGAAATACCATACCAGGT	0.368			NA											8	42					0	0	0.00308	0	0
LMAN1L	79748	broad.mit.edu	37	15	75116699	75116699	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr15:75116699C>T	uc002ayt.1	+	13	1333	c.1331C>T	c.(1330-1332)GCA>GTA	p.A444V	LMAN1L_uc010bke.1_Missense_Mutation_p.A432V|CPLX3_uc002ayu.1_5'Flank	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	444	Lumenal (Potential).					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						CAGAAGGCAGCAGCCAAGGCC	0.587			NA											51	65					0	0	0.01441	0	0
TP53	7157	broad.mit.edu	37	17	7578388	7578388	+	Missense_Mutation	SNP	C	C	T	rs138525931	by1000genomes	TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr17:7578388C>T	uc002gim.2	-	5	736	c.542G>A	c.(541-543)CGC>CAC	p.R181H	TP53_uc002gig.1_Missense_Mutation_p.R181H|TP53_uc002gih.2_Missense_Mutation_p.R181H|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R49H|TP53_uc010cng.1_Missense_Mutation_p.R49H|TP53_uc002gii.1_Missense_Mutation_p.R49H|TP53_uc010cnh.1_Missense_Mutation_p.R181H|TP53_uc010cni.1_Missense_Mutation_p.R181H|TP53_uc002gij.2_Missense_Mutation_p.R181H|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R88H|TP53_uc002gio.2_Missense_Mutation_p.R49H|TP53_uc010vug.1_Missense_Mutation_p.R142H	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	181	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R181H(20)|p.R181P(14)|p.R181C(13)|p.P177_C182delPHHERC(8)|p.0?(7)|p.R181L(3)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.R181R(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.K164_P219del(1)|p.R49P(1)|p.C176fs*65(1)|p.R181G(1)|p.V173fs*23(1)|p.R181>XXXXXXX(1)|p.R88P(1)|p.R81fs*24(1)|p.R42fs*24(1)|p.E180_S183del(1)|p.R174fs*3(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTGAGCAGCGCTCATGGTG	0.637	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			15	19					0	0	0.00499	0	0
ATP8B1	5205	broad.mit.edu	37	18	55355661	55355661	+	Silent	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr18:55355661G>A	uc002lgw.2	-	12	1299	c.1299C>T	c.(1297-1299)CCC>CCT	p.P433P	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	433	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				TAGCTTTTGCGGGTGTGTCCT	0.443			NA							Byler_disease				35	42					0	0	0.00623	0	0
MUC16	94025	broad.mit.edu	37	19	8971691	8971691	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr19:8971691C>T	uc002mkp.2	-	78	43105	c.42901G>A	c.(42901-42903)GAC>AAC	p.D14301N	MUC16_uc010dwi.2_RNA|MUC16_uc010dwj.2_Missense_Mutation_p.D1101N|MUC16_uc010xki.1_RNA	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ACATGGATGTCCACCAACTGG	0.527			NA											15	29					0	0	0.004007	0	0
ICAM5	7087	broad.mit.edu	37	19	10403476	10403476	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr19:10403476G>C	uc002mnu.3	+	5	1215	c.1150G>C	c.(1150-1152)GAC>CAC	p.D384H	ICAM5_uc002mnv.3_Missense_Mutation_p.D259H	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	384	Extracellular (Potential).|Ig-like C2-type 4.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			CTTCTTCTGCGACGCCACCCT	0.622			NA											8	30					0	0	0.004482	0	0
PAF1	54623	broad.mit.edu	37	19	39879634	39879634	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr19:39879634G>T	uc002old.2	-	8	764	c.589C>A	c.(589-591)CCC>ACC	p.P197T	PAF1_uc002ole.1_Missense_Mutation_p.P187T|PAF1_uc010xuv.1_RNA|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	197					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			GTGACTCGGGGTTTGCTGTAA	0.552			NA											26	67					9.39395e-14	1.02638e-13	0.00632	1	0
CYP2A7	1549	broad.mit.edu	37	19	41386439	41386439	+	Silent	SNP	C	C	T	rs139522441		TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr19:41386439C>T	uc002opm.2	-	3	980	c.438G>A	c.(436-438)GAG>GAA	p.E146E	CYP2A7_uc002opo.2_Silent_p.E146E|CYP2A7_uc002opn.2_Silent_p.E95E	NM_000764	NP_000755	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A,	146						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			GGATGCGCTCCTCGATGCCTC	0.667			NA											15	10					0	0	0.003163	0	0
CEACAM7	1087	broad.mit.edu	37	19	42190882	42190882	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr19:42190882T>C	uc002ori.1	-	2	337	c.335A>G	c.(334-336)AAC>AGC	p.N112S	CEACAM7_uc010ehx.2_Missense_Mutation_p.N112S|CEACAM7_uc010ehy.1_Missense_Mutation_p.N112S	NM_006890	NP_008821	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion	112	Ig-like V-type.					anchored to membrane|integral to membrane|plasma membrane				ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		GTGGGTGACGTTCTGGATCAG	0.413			NA											17	114					0	0	0.008871	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657206	40657206	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr2:40657206C>A	uc002rrx.2	-	1	239	c.215G>T	c.(214-216)GGG>GTG	p.G72V	SLC8A1_uc002rry.2_Missense_Mutation_p.G72V|SLC8A1_uc002rrz.2_Missense_Mutation_p.G72V|SLC8A1_uc002rsa.2_Missense_Mutation_p.G72V|SLC8A1_uc002rsd.3_Missense_Mutation_p.G72V|SLC8A1_uc002rsb.1_Missense_Mutation_p.G72V|SLC8A1_uc010fan.1_Missense_Mutation_p.G72V|SLC8A1_uc002rsc.1_Missense_Mutation_p.G72V	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	72	Extracellular (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AATTTTGTCCCCAAAAGAAGG	0.423			NA											19	43					1.15919e-05	1.17917e-05	0.008871	1	0
ASTL	431705	broad.mit.edu	37	2	96799269	96799269	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr2:96799269C>T	uc010yui.1	-	5	350	c.350G>A	c.(349-351)CGC>CAC	p.R117H		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	117					proteolysis		metalloendopeptidase activity|zinc ion binding				0						GATGACCTGGCGGCTGGGCTC	0.567			NA											16	27					0	0	0.003163	0	0
SNRNP200	23020	broad.mit.edu	37	2	96955643	96955643	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr2:96955643C>T	uc002svu.2	-	21	2920	c.2834G>A	c.(2833-2835)GGA>GAA	p.G945E	SNRNP200_uc002svw.1_Missense_Mutation_p.G17E	NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	945						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						CAGGGGATCTCCCTTGAGGTC	0.537			NA											11	88					0	0	0.010729	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20493648	20493649	+	Missense_Mutation	DNP	AG	AG	CC			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr20:20493648_20493649AG>CC	uc002wrz.2	-	32	4507_4508	c.4364_4365CT>GG	c.(4363-4365)TCT>TGG	p.S1455W	RALGAPA2_uc010gcx.2_Missense_Mutation_p.S1159W|RALGAPA2_uc010zsg.1_Missense_Mutation_p.S903W|RALGAPA2_uc002wsa.1_Missense_Mutation_p.S227W	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1455					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CATCAGAGAGAGAGCCCACTGG	0.48			NA											6	13					0	0	0.004672	0	0
CABLES2	81928	broad.mit.edu	37	20	60966386	60966386	+	Silent	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr20:60966386C>T	uc002ycv.2	-	9	1222	c.1215G>A	c.(1213-1215)AAG>AAA	p.K405K		NM_031215	NP_112492	Q9BTV7	CABL2_HUMAN	Cdk5 and Abl enzyme substrate 2	405					cell cycle|cell division|regulation of cell cycle|regulation of cell division		cyclin-dependent protein kinase regulator activity			pancreas(1)	1	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)			CAGCGCACAGCTTGCGGTTCT	0.637			NA											35	209					0	0	0.019004	0	0
SAMSN1	64092	broad.mit.edu	37	21	15889271	15889271	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr21:15889271G>A	uc002yju.1	-	3	303	c.221C>T	c.(220-222)TCA>TTA	p.S74L	SAMSN1_uc010gky.1_Intron|SAMSN1_uc002yjv.1_Missense_Mutation_p.S142L	NM_022136	NP_071419	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization	74					negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			ovary(3)|pancreas(1)	4				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CATTGTCCATGAAATAGCTCT	0.343			NA											6	30					0	0	0.021553	0	0
C3orf23	285343	broad.mit.edu	37	3	44434409	44434409	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr3:44434409G>C	uc010him.2	+	6	880	c.635G>C	c.(634-636)AGA>ACA	p.R212T	C3orf23_uc003cnd.3_Missense_Mutation_p.R212T|C3orf23_uc003cne.3_Missense_Mutation_p.R68T	NM_173826	NP_776187	Q8N3R3	CC023_HUMAN	hypothetical protein LOC285343 isoform 1	212						mitochondrion				upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(197;0.0468)|Kidney(197;0.0585)		TTGCCACTTAGAAAAGAACTA	0.323			NA											9	59					0	0	0.004482	0	0
RHO	6010	broad.mit.edu	37	3	129251411	129251411	+	Missense_Mutation	SNP	G	G	C	rs148222991		TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr3:129251411G>C	uc003emt.2	+	4	827	c.732G>C	c.(730-732)CAG>CAC	p.Q244H		NM_000539	NP_000530	P08100	OPSD_HUMAN	rhodopsin	244	Cytoplasmic.				protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding				0		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CCACCACACAGAAGGCAGAGA	0.622	Esophageal Squamous(118;214 1623 30842 43234 46940)		NA											7	61					0	0	0.001984	0	0
EPHB1	2047	broad.mit.edu	37	3	134851754	134851754	+	Missense_Mutation	SNP	C	C	T	rs56396912		TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr3:134851754C>T	uc003eqt.2	+	5	1380	c.1160C>T	c.(1159-1161)ACG>ATG	p.T387M	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_Translation_Start_Site	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	387	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding	p.T387M(4)|p.T387T(1)		lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CTGGGCCTGACGGAGTGCCGC	0.612			NA											6	34					0	0	0.021553	0	0
CSN3	1448	broad.mit.edu	37	4	71114727	71114727	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr4:71114727G>C	uc003hfe.3	+	4	158	c.100G>C	c.(100-102)GAT>CAT	p.D34H		NM_005212	NP_005203	P07498	CASK_HUMAN	casein kappa precursor	34						extracellular region	protein binding			ovary(2)|kidney(1)|central_nervous_system(1)	4						CCATGAGAATGATGAAAGACC	0.299			NA											9	23					0	0	0.008291	0	0
NDST3	9348	broad.mit.edu	37	4	119059304	119059304	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr4:119059304G>T	uc003ibx.2	+	5	1723	c.1320G>T	c.(1318-1320)AAG>AAT	p.K440N	NDST3_uc011cgf.1_Missense_Mutation_p.K359N	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	440	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CCTGGAAGAAGGTCTGGAATA	0.498			NA											28	23					1.32181e-22	1.49975e-22	0.007291	1	0
CMYA5	202333	broad.mit.edu	37	5	79032290	79032290	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr5:79032290A>T	uc003kgc.2	+	2	7774	c.7702A>T	c.(7702-7704)ATG>TTG	p.M2568L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	2568						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AGCCGAGTCTATGAGTAGAGA	0.363			NA											6	23					0	0	0.001984	0	0
VCAN	1462	broad.mit.edu	37	5	82875982	82875982	+	Splice_Site	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr5:82875982G>A	uc003kii.3	+	14	10419	c.10063_splice	c.e14+1	p.P3355_splice	VCAN_uc003kij.3_Splice_Site_p.P2368_splice|VCAN_uc010jau.2_Splice_Site_p.P1601_splice|VCAN_uc003kik.3_Splice_Site_p.P614_splice|VCAN_uc003kil.3_Splice_Site_p.P2019_splice	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor						cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGCATGAACCGTAAGTGGTCC	0.433			NA											20	20					0	0	0.008871	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179292850	179292850	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr5:179292850C>G	uc003mlh.2	-	20	2990	c.2953G>C	c.(2953-2955)GAG>CAG	p.E985Q	TBC1D9B_uc003mli.2_Missense_Mutation_p.E968Q|TBC1D9B_uc003mlj.2_Missense_Mutation_p.E967Q|TBC1D9B_uc003mlf.2_Missense_Mutation_p.E59Q|TBC1D9B_uc003mlg.2_Missense_Mutation_p.E144Q|TBC1D9B_uc011dgv.1_Missense_Mutation_p.E144Q	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	985						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTCTCTCCTCACTTCCACTT	0.507			NA											9	76					0	0	0.010729	0	0
ZNF322A	79692	broad.mit.edu	37	6	26638557	26638557	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:26638557C>T	uc003nil.3	-	4	854	c.225G>A	c.(223-225)ATG>ATA	p.M75I	ZNF322A_uc003nij.2_5'Flank	NM_024639	NP_078915	Q6U7Q0	Z322A_HUMAN	zinc finger protein 322A	75	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding				0						TTTTCTCACACATATCACATT	0.378			NA											23	146					0	0	0.007835	0	0
USP49	25862	broad.mit.edu	37	6	41773992	41773992	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:41773992G>A	uc003ori.2	-	4	952	c.730C>T	c.(730-732)CGC>TGC	p.R244C		NM_018561	NP_061031	Q70CQ1	UBP49_HUMAN	ubiquitin thioesterase 49	244					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(28;0.0919)|Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000309)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			GCCGGCTGGCGACGCAGCTTG	0.517			NA											16	36					0	0	0.003163	0	0
ABCC10	89845	broad.mit.edu	37	6	43400264	43400264	+	Silent	SNP	C	C	G			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:43400264C>G	uc003ouy.1	+	3	761	c.546C>G	c.(544-546)CTC>CTG	p.L182L	ABCC10_uc003ouz.1_Silent_p.L139L	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	182	Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			TGGCTGCACTCTTGGCCTATG	0.637			NA											37	83					0	0	0.017118	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47251956	47251956	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:47251956C>A	uc003oyv.2	-	3	1394	c.961G>T	c.(961-963)GGC>TGC	p.G321C		NM_014452	NP_055267	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily,	321	Extracellular (Potential).				cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity				0			Lung(136;0.189)			GACTTCTCGCCCCCAGTGGCC	0.562			NA											19	126					7.41877e-09	7.81621e-09	0.012319	1	0
MDN1	23195	broad.mit.edu	37	6	90385846	90385846	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:90385846T>C	uc003pnn.1	-	77	12736	c.12620A>G	c.(12619-12621)AAC>AGC	p.N4207S		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	4207					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TAGTGCTGCGTTAAGCCTGGC	0.478			NA											10	27					0	0	0.010729	0	0
TRAF3IP2	10758	broad.mit.edu	37	6	111912597	111912597	+	Silent	SNP	G	G	C			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:111912597G>C	uc011ebc.1	-	3	1308	c.693C>G	c.(691-693)CTC>CTG	p.L231L	TRAF3IP2_uc003pvg.2_Silent_p.L231L|TRAF3IP2_uc003pvf.2_Silent_p.L231L|TRAF3IP2_uc010kdw.2_Silent_p.L231L|TRAF3IP2_uc010kdx.2_Silent_p.L231L	NM_147686	NP_679211	O43734	CIKS_HUMAN	TRAF3 interacting protein 2 isoform 2	240					intracellular signal transduction|positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular				ovary(2)|central_nervous_system(1)	3		all_cancers(87;7.87e-06)|Acute lymphoblastic leukemia(125;3.61e-09)|all_hematologic(75;2.63e-07)|all_epithelial(87;0.0024)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.033)|all cancers(137;0.0412)|Epithelial(106;0.0732)		CCCTGGACCTGAGAGGTCTGG	0.572			NA											11	70					0	0	0.010729	0	0
TAAR8	83551	broad.mit.edu	37	6	132874690	132874690	+	Missense_Mutation	SNP	A	A	G	rs143776669		TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr6:132874690A>G	uc011ecj.1	+	1	859	c.859A>G	c.(859-861)ACC>GCC	p.T287A		NM_053278	NP_444508	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	287	Helical; Name=7; (Potential).					plasma membrane	G-protein coupled receptor activity			ovary(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		GGGCTTCCTGACCCCTGCCTA	0.388			NA											11	114					0	0	0.010729	0	0
MAGI2	9863	broad.mit.edu	37	7	78256514	78256514	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr7:78256514C>G	uc003ugx.2	-	3	714	c.460G>C	c.(460-462)GAT>CAT	p.D154H	MAGI2_uc003ugy.2_Missense_Mutation_p.D154H|MAGI2_uc011kgr.1_5'UTR|MAGI2_uc011kgs.1_5'UTR	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	154	Guanylate kinase-like.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				AAAATATAATCCACTCCAGGG	0.393			NA											5	44					0	0	0.014758	0	0
MET	4233	broad.mit.edu	37	7	116411902	116411902	+	Splice_Site	SNP	G	G	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr7:116411902G>A	uc003vij.2	+	14	3075	c.2888_splice	c.e14-1	p.D963_splice	MET_uc010lkh.2_Splice_Site_p.D981_splice|MET_uc011knj.1_Splice_Site_p.D533_splice	NM_000245	NP_000236	P08581	MET_HUMAN	met proto-oncogene isoform b precursor						axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.982_1028del47(1)|p.?(1)		upper_aerodigestive_tract(63)|lung(41)|kidney(18)|NS(10)|ovary(5)|thyroid(4)|central_nervous_system(4)|stomach(3)|liver(3)|pleura(2)|large_intestine(2)|breast(2)|testis(1)|skin(1)	159	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TCTGTTTTAAGATCTGGGCAG	0.458			NA	Mis		papillary renal|head-neck squamous cell 	papillary renal			Hereditary_Papillary_Renal_Carcinoma_(type_1)				24	9					0	0	0.004656	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811125	5811125	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chrX:5811125C>A	uc010ndh.2	-	6	2685	c.2184G>T	c.(2182-2184)GAG>GAT	p.E728D	NLGN4X_uc004crp.2_Missense_Mutation_p.E748D|NLGN4X_uc004crq.2_Missense_Mutation_p.E728D|NLGN4X_uc010ndi.2_Missense_Mutation_p.E765D|NLGN4X_uc004crr.2_Missense_Mutation_p.E728D|NLGN4X_uc010ndj.2_Missense_Mutation_p.E728D	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	728	Cytoplasmic (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						GAGACATGATCTCTTCGTTCT	0.552			NA											22	54					1.55795e-14	1.73432e-14	0.012319	1	0
SLC6A15	55117	broad.mit.edu	37	12	85270377	85270378	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr12:85270377_85270378insT	uc001szv.2	-	6	1258_1259	c.765_766insA	c.(763-768)TATTTTfs	p.Y255fs	SLC6A15_uc010sul.1_Frame_Shift_Ins_p.Y148fs	NM_182767	NP_877499	Q9H2J7	S6A15_HUMAN	solute carrier family 6, member 15 isoform 1	255_256	Helical; Name=5; (Potential).				cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			pancreas(2)|ovary(1)	3						AGAGAACTAAAATATATGATCT	0.302			NA											14	22	---	---	---	---	NA	NA	NA	NA	NA
RB1	5925	broad.mit.edu	37	13	48951168	48951168	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr13:48951168delC	uc001vcb.2	+	13	1496	c.1330delC	c.(1330-1332)CAGfs	p.Q444fs	RB1_uc010act.1_Frame_Shift_Del_p.Q145fs	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	444	Domain A.|Pocket; binds T and E1A.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)|p.Q444H(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATTGGATCACAGGTAACTTG	0.333			6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			16	15	---	---	---	---	NA	NA	NA	NA	NA
ZNF320	162967	broad.mit.edu	37	19	53384185	53384185	+	Frame_Shift_Del	DEL	C	C	-	rs6509701	byFrequency	TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr19:53384185delC	uc002qag.2	-	4	1385	c.1194delG	c.(1192-1194)GCGfs	p.A398fs	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Frame_Shift_Del_p.A344fs|ZNF320_uc002qai.2_Frame_Shift_Del_p.A398fs	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	398	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ATGCGAGGTACGCTTTTGTAC	0.393			NA											12	41	---	---	---	---	NA	NA	NA	NA	NA
CTNNBL1	56259	broad.mit.edu	37	20	36386054	36386072	+	Splice_Site	DEL	CTCTGGTAAGTTGCACATC	CTCTGGTAAGTTGCACATC	-			TCGA-78-7143-01A-11D-2036-08	TCGA-78-7143-10A-01D-2036-08	CTCTGGTAAGTTGCACATC	CTCTGGTAAGTTGCACATC	-	-	CTCTGGTAAGTTGCACATC	CTCTGGTAAGTTGCACATC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	b710996c-8d35-4a2c-bc51-389b3e35b0f3	11e7f779-f338-41d4-914d-19f50cc524c3	g.chr20:36386054_36386072delCTCTGGTAAGTTGCACATC	uc010zvw.1	+	6	655	c.564_splice	c.e6+1	p.L188_splice	CTNNBL1_uc002xhh.2_Intron|CTNNBL1_uc002xhi.2_Splice_Site	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1						apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				CTCATCGATGCTCTGGTAAGTTGCACATCCTCTGGGGTT	0.502	Ovarian(184;582 2038 3273 4106 42608)		NA											11	19	---	---	---	---	NA	NA	NA	NA	NA