Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ATAD3B	83858	broad.mit.edu	37	1	1412682	1412682	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:1412682G>T	uc001afv.2	+	2	335	c.234G>T	c.(232-234)GCG>GCT	p.A78A	ATAD3B_uc001afw.2_5'Flank|ATAD3B_uc001afx.2_5'Flank	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	78	Potential.						ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		TGAATCTGGCGCAGATGCAGG	0.562			NA											75	22					4.59617e-45	8.26114e-45	0.00361	1	0
SLC35E2B	728661	broad.mit.edu	37	1	1607561	1607561	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:1607561C>A	uc001ahf.3	-	4	1321	c.400G>T	c.(400-402)GCC>TCC	p.A134S	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc009vkl.1_Missense_Mutation_p.A134S|SLC35E2B_uc001ahg.3_Missense_Mutation_p.A134S|SLC35E2B_uc001ahh.3_Missense_Mutation_p.A134S|SLC35E2_uc009vkm.1_Intron|SLC35E2B_uc009vkn.1_Missense_Mutation_p.A134S	NM_001110781	NP_001104251	P0CK96	S352B_HUMAN	similar to solute carrier family 35, member E2	134						integral to membrane					0						GAAAGCCGGGCCTTGTGCTGA	0.527			NA											53	0					2.01807e-28	3.31883e-28	0.00361	1	0
AJAP1	55966	broad.mit.edu	37	1	4829947	4829947	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:4829947C>T	uc001alm.1	+	3	1245	c.864C>T	c.(862-864)GTC>GTT	p.V288V	AJAP1_uc001aln.2_Silent_p.V288V	NM_001042478	NP_001035943	Q9UKB5	AJAP1_HUMAN	adherens junction associated protein 1	288	Helical; Signal-anchor for type III membrane protein; (Potential).				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				lung(1)	1	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		CCATCACCGTCTCCCTCATCA	0.557			NA											302	109					0	0	0.00361	0	0
CHD5	26038	broad.mit.edu	37	1	6181567	6181567	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:6181567G>T	uc001amb.1	-	32	4866	c.4766C>A	c.(4765-4767)CCC>CAC	p.P1589H	CHD5_uc001alz.1_Missense_Mutation_p.P446H|CHD5_uc001ama.1_RNA|CHD5_uc001amc.1_RNA|CHD5_uc009vlx.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1589					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GACTTCCAGGGGCTGCCTTGG	0.592			NA											7	27					8.12818e-05	8.70909e-05	0.001984	1	0
CHD5	26038	broad.mit.edu	37	1	6206398	6206398	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:6206398C>T	uc001amb.1	-	11	1776	c.1676G>A	c.(1675-1677)GGG>GAG	p.G559E	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	559					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GTCTTCATCCCCAGAGCCGTA	0.557			NA											116	35					0	0	0.00361	0	0
C1orf187	374946	broad.mit.edu	37	1	11769435	11769435	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:11769435G>A	uc001asr.1	+	3	695	c.555G>A	c.(553-555)GCG>GCA	p.A185A		NM_198545	NP_940947	Q8NBI3	DRAXI_HUMAN	chromosome 1 open reading frame 187 precursor	185					axon guidance|commissural neuron differentiation in spinal cord|dorsal spinal cord development|forebrain development|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region					0	Ovarian(185;0.249)	Lung NSC(185;4.15e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.48e-06)|COAD - Colon adenocarcinoma(227;0.000283)|BRCA - Breast invasive adenocarcinoma(304;0.000316)|Kidney(185;0.000841)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|STAD - Stomach adenocarcinoma(313;0.00754)|READ - Rectum adenocarcinoma(331;0.0651)		CCAGCCTGGCGCCCACCATGT	0.632			NA											5	29					0	0	0.000602	0	0
LOC649330	649330	broad.mit.edu	37	1	12907569	12907569	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:12907569G>T	uc009vno.2	-	1	669	c.574C>A	c.(574-576)CAG>AAG	p.Q192K	HNRNPCL1_uc010obf.1_Missense_Mutation_p.Q192K	NM_001146181	NP_001139653	B7ZW38	B7ZW38_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	192							nucleic acid binding|nucleotide binding				0						TCCACTTTCTGTTTTATCTGG	0.433			NA											60	398					7.65386e-43	1.36555e-42	0.00361	1	0
NBPF1	55672	broad.mit.edu	37	1	16907943	16907943	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:16907943C>A	uc009vos.1	-	15	2239	c.1351G>T	c.(1351-1353)GAG>TAG	p.E451*	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Nonsense_Mutation_p.E180*	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	451	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGTACTTTCTCAGCCTCCTCA	0.433			NA											51	459					4.02937e-33	6.87196e-33	0.00361	1	0
MST1P9	11223	broad.mit.edu	37	1	17084510	17084510	+	Silent	SNP	G	G	A	rs61769731	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:17084510G>A	uc010ock.1	-	12	1588	c.1588C>T	c.(1588-1590)CTA>TTA	p.L530L	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Silent_p.L130L	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						ACCCGCTGTAGGCCTGGCTCT	0.577			NA											18	199					0	0	0.00499	0	0
MST1P9	11223	broad.mit.edu	37	1	17085373	17085373	+	Missense_Mutation	SNP	C	C	T	rs2092130	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:17085373C>T	uc010ock.1	-	10	1318	c.1318G>A	c.(1318-1320)GGG>AGG	p.G440R	CROCC_uc009voy.1_Intron|MST1P9_uc001azp.3_Missense_Mutation_p.M1I	NR_002729				SubName: Full=Hepatocyte growth factor-like protein homolog;												0						TGGCTATCCCCATCTGGGTCT	0.602			NA											8	139					0	0	0.008871	0	0
PADI6	353238	broad.mit.edu	37	1	17708469	17708469	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:17708469G>A	uc001bak.1	+	6	561	c.561G>A	c.(559-561)ACG>ACA	p.T187T		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	179					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CAGAAATAACGAATCTGTCCC	0.507			NA											11	142					0	0	0.000978	0	0
PAX7	5081	broad.mit.edu	37	1	19029612	19029612	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:19029612C>G	uc001bay.2	+	7	1575	c.977C>G	c.(976-978)CCT>CGT	p.P326R	PAX7_uc001baz.2_Missense_Mutation_p.P324R|PAX7_uc010oct.1_Missense_Mutation_p.P326R	NM_002584	NP_002575	P23759	PAX7_HUMAN	paired box 7 isoform 1	326					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		GTGCACCGGCCTCAGCCCCTG	0.667			NA	T	FOXO1A	alveolar rhabdomyosarcoma								17	37					0	0	0.001882	0	0
CAMK2N1	55450	broad.mit.edu	37	1	20810184	20810184	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:20810184G>T	uc001bdh.2	-	2	1051	c.195C>A	c.(193-195)GAC>GAA	p.D65E	CAMK2N1_uc001bdg.2_RNA	NM_018584	NP_061054	Q7Z7J9	CK2N1_HUMAN	calcium/calmodulin-dependent protein kinase II	65	Inhibitory domain (By similarity).					cell junction|postsynaptic density|postsynaptic membrane|synaptosome					0		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000247)|Lung NSC(340;0.000285)|Breast(348;0.0013)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|COAD - Colon adenocarcinoma(152;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000132)|Kidney(64;0.00016)|GBM - Glioblastoma multiforme(114;0.00116)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.195)		TTTTCAGCACGTCATCAATCC	0.478			NA											9	50					1.58986e-06	1.77324e-06	0.008291	1	0
KIF17	57576	broad.mit.edu	37	1	21016807	21016807	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:21016807G>C	uc001bdr.3	-	7	1373	c.1255C>G	c.(1255-1257)CGG>GGG	p.R419G	KIF17_uc009vpx.2_5'UTR|KIF17_uc001bds.3_Missense_Mutation_p.R419G	NM_020816	NP_065867	Q9P2E2	KIF17_HUMAN	kinesin family member 17 isoform a	419	Potential.				microtubule-based movement|protein transport	cytoplasm|microtubule	ATP binding			ovary(3)|skin(1)	4		all_lung(284;2.99e-05)|Lung NSC(340;3.26e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|COAD - Colon adenocarcinoma(152;1.43e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000168)|Kidney(64;0.000221)|GBM - Glioblastoma multiforme(114;0.000651)|KIRC - Kidney renal clear cell carcinoma(64;0.0031)|STAD - Stomach adenocarcinoma(196;0.00336)|READ - Rectum adenocarcinoma(331;0.0686)|Lung(427;0.209)		GCTTTCAGCCGGGCCAGGCGC	0.562			NA											17	47					0	0	0.00499	0	0
ECE1	1889	broad.mit.edu	37	1	21586789	21586789	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:21586789T>C	uc001bek.2	-	5	665	c.590A>G	c.(589-591)AAA>AGA	p.K197R	ECE1_uc001bem.2_Missense_Mutation_p.K181R|ECE1_uc001bej.2_Missense_Mutation_p.K185R|ECE1_uc001bei.2_Missense_Mutation_p.K194R|ECE1_uc010odl.1_Missense_Mutation_p.K197R|ECE1_uc009vqa.1_Missense_Mutation_p.K197R	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	197	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		CATTAGAGGTTTGGCCCTGAG	0.607			NA											92	269					0	0	0.00361	0	0
EPHA8	2046	broad.mit.edu	37	1	22903330	22903330	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:22903330C>A	uc001bfx.1	+	3	905	c.780C>A	c.(778-780)TGC>TGA	p.C260*	EPHA8_uc001bfw.2_Nonsense_Mutation_p.C260*	NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	260	Extracellular (Potential).|Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TCGGCAAATGCGTGTGCAGTG	0.682			NA											25	14					2.41591e-17	3.39562e-17	0.004656	1	0
RHCE	6006	broad.mit.edu	37	1	25701856	25701856	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:25701856C>A	uc001bkf.2	-	8	1223	c.1137G>T	c.(1135-1137)ACG>ACT	p.T379T	RHCE_uc001bkg.2_Missense_Mutation_p.V335F|RHCE_uc001bkh.2_Intron|RHCE_uc001bki.2_Silent_p.T228T|RHCE_uc001bkj.2_Silent_p.T363T	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	379						integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGACCAGACGTGAGAGCTA	0.572			NA											48	176					2.74695e-27	4.46438e-27	0.00361	1	0
FAM46B	115572	broad.mit.edu	37	1	27338968	27338968	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:27338968C>T	uc010ofj.1	-	1	366	c.194G>A	c.(193-195)AGC>AAC	p.S65N		NM_052943	NP_443175	Q96A09	FA46B_HUMAN	hypothetical protein LOC115572	65										central_nervous_system(1)	1		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		AATCGGCTCGCTCAGAAGAGC	0.647			NA											16	10					0	0	0.003163	0	0
SESN2	83667	broad.mit.edu	37	1	28601354	28601354	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:28601354C>A	uc001bps.2	+	8	1392	c.1039C>A	c.(1039-1041)CAT>AAT	p.H347N		NM_031459	NP_113647	P58004	SESN2_HUMAN	sestrin 2	347					cell cycle arrest	cytoplasm|nucleus				skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CTGGGAAGACCATGGCTACTC	0.557			NA											29	80					2.70662e-09	3.23523e-09	0.009535	1	0
Unknown	0	broad.mit.edu	37	1	33772993	33772993	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:33772993G>A	uc001bxd.1	-	5	397	c.397C>T	c.(397-399)CAG>TAG	p.Q133*		NM_001080438	NP_001073907			RecName: Full=Alpha 1,3-galactosyltransferase 2;          Short=A3galt2;          EC=2.4.1.87; AltName: Full=Isoglobotriaosylceramide synthase; AltName: Full=iGb3 synthase;          Short=iGb3S; Flags: Precursor;												NA						ATCACGCTCTGGCCCGCCATG	0.697			NA											25	75					0	0	0.007291	0	0
CSMD2	114784	broad.mit.edu	37	1	34083116	34083116	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:34083116G>C	uc001bxn.1	-	38	5838	c.5809C>G	c.(5809-5811)CCG>GCG	p.P1937A	CSMD2_uc001bxm.1_Missense_Mutation_p.P1977A|CSMD2_uc001bxo.1_Missense_Mutation_p.P850A	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1937	Sushi 11.|Extracellular (Potential).					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCATATCCCGGCTCACACTGG	0.587			NA											25	14					0	0	0.00333	0	0
CSMD2	114784	broad.mit.edu	37	1	34174850	34174850	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:34174850C>A	uc001bxn.1	-	22	3324	c.3295G>T	c.(3295-3297)GGG>TGG	p.G1099W	CSMD2_uc001bxm.1_Missense_Mutation_p.G1139W|CSMD2_uc001bxo.1_Missense_Mutation_p.G12W	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1099	Extracellular (Potential).|CUB 7.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACTGAATTCCCACACTCAGCT	0.463			NA											10	28					0.000442599	0.000466224	0.006214	1	0
STK40	83931	broad.mit.edu	37	1	36809008	36809008	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:36809008G>C	uc001cak.1	-	11	1453	c.1046C>G	c.(1045-1047)CCT>CGT	p.P349R	STK40_uc001cal.1_Missense_Mutation_p.P354R|STK40_uc001cam.1_Missense_Mutation_p.P349R|STK40_uc009vva.1_Intron|STK40_uc001can.1_Missense_Mutation_p.P349R	NM_032017	NP_114406	Q8N2I9	STK40_HUMAN	serine/threonine kinase 40	349						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1		Myeloproliferative disorder(586;0.0393)				ATCAATGTCAGGAACCACTTG	0.592			NA											20	8					0	0	0.001882	0	0
KIAA0754	643314	broad.mit.edu	37	1	39876984	39876984	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:39876984G>A	uc009vvt.1	+	1	1809	c.1047G>A	c.(1045-1047)CTG>CTA	p.L349L	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	213											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGACTTTTCTGATGGCAGATG	0.468			NA									OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	87					0	0	0.002299	0	0
TIE1	7075	broad.mit.edu	37	1	43783064	43783065	+	Missense_Mutation	DNP	CA	CA	AT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:43783064_43783065CA>AT	uc001ciu.2	+	15	2683_2684	c.2604_2605CA>AT	c.(2602-2607)GCCATC>GCATTC	p.I869F	TIE1_uc010oke.1_Missense_Mutation_p.I824F|TIE1_uc009vwq.2_Missense_Mutation_p.I825F|TIE1_uc010okg.1_Missense_Mutation_p.I514F	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	869	Cytoplasmic (Potential).|Protein kinase.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TGAACGCAGCCATCAAAATGCT	0.589			NA											47	34					0	0	0.004672	0	0
CYP4B1	1580	broad.mit.edu	37	1	47279205	47279205	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:47279205G>A	uc001cqm.3	+	5	631	c.547G>A	c.(547-549)GAT>AAT	p.D183N	CYP4B1_uc009vyl.1_Missense_Mutation_p.D20N|CYP4B1_uc001cqn.3_Missense_Mutation_p.D183N|CYP4B1_uc009vym.2_Missense_Mutation_p.D168N|CYP4B1_uc010omk.1_Missense_Mutation_p.D20N|CYP4B1_uc010oml.1_Missense_Mutation_p.D20N	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	183					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					CATCTTCTGCGATGTGGGTCA	0.582			NA											13	48					0	0	0.001855	0	0
FOXD2	2306	broad.mit.edu	37	1	47904182	47904182	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:47904182G>T	uc001crm.2	+	1	2494	c.375G>T	c.(373-375)CTG>CTT	p.L125L		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	125					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		GGAGCCCGCTGGTGAAGCCGC	0.358			NA											16	33					1.15088e-07	1.32252e-07	0.004007	1	0
DAB1	1600	broad.mit.edu	37	1	57538066	57538066	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:57538066C>A	uc001cys.1	-	7	1002	c.328G>T	c.(328-330)GTT>TTT	p.V110F	DAB1_uc001cyt.1_Missense_Mutation_p.V110F|DAB1_uc001cyq.1_Missense_Mutation_p.V110F|DAB1_uc001cyr.1_Intron|DAB1_uc009vzw.1_Missense_Mutation_p.V110F|DAB1_uc009vzx.1_Missense_Mutation_p.V110F	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	110	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						ATTTCATGAACAGCATGATGA	0.408			NA											43	29					6.1244e-12	7.73651e-12	0.007835	1	0
KANK4	163782	broad.mit.edu	37	1	62739543	62739543	+	Missense_Mutation	SNP	G	G	T	rs143096938		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:62739543G>T	uc001dah.3	-	3	1610	c.1233C>A	c.(1231-1233)GAC>GAA	p.D411E	KANK4_uc001dai.3_Intron|KANK4_uc001dag.3_5'Flank	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	411										ovary(3)|skin(2)|lung(1)	6						TCACCATCACGTCCGTCTGGC	0.517			NA											108	82					2.21257e-79	4.16255e-79	0.00361	1	0
JAK1	3716	broad.mit.edu	37	1	65325846	65325846	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:65325846C>A	uc001dbu.1	-	9	1525	c.1276G>T	c.(1276-1278)GAC>TAC	p.D426Y	JAK1_uc009wam.1_Missense_Mutation_p.D414Y	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1	426					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		GGGGCCACGTCGGTGCAGAGG	0.542			NA	Mis		ALL								13	52					7.93312e-07	8.90979e-07	0.00245	1	0
WDR78	79819	broad.mit.edu	37	1	67288201	67288201	+	Splice_Site	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:67288201C>G	uc001dcx.2	-	16	2396	c.2340_splice	c.e16-1	p.T780_splice	WDR78_uc009waw.2_Splice_Site_p.T493_splice|WDR78_uc009wax.2_Splice_Site	NM_024763	NP_079039	Q5VTH9	WDR78_HUMAN	WD repeat domain 78 isoform 1											ovary(2)	2						AGGGTCCAAACTGTAATGAAA	0.294			NA											6	21					0	0	0.001168	0	0
NEGR1	257194	broad.mit.edu	37	1	72748003	72748003	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:72748003T>A	uc001dfw.2	-	1	275	c.175A>T	c.(175-177)AGG>TGG	p.R59W	NEGR1_uc010oqs.1_Missense_Mutation_p.R59W	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	59	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		TCTTCCTACCTAAGCACCGCC	0.532			NA											29	19					0	0	0.007291	0	0
C1orf173	127254	broad.mit.edu	37	1	75055736	75055736	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:75055736G>A	uc001dgg.2	-	12	1974	c.1755C>T	c.(1753-1755)TCC>TCT	p.S585S	uc001dgh.2_Intron|C1orf173_uc001dgi.3_Silent_p.S379S	NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	585	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						GGTGACTTCTGGATGAGGTTG	0.393			NA											14	21					0	0	0.001855	0	0
C1orf173	127254	broad.mit.edu	37	1	75114965	75114965	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:75114965G>T	uc001dgg.2	-	2	277	c.58C>A	c.(58-60)CAC>AAC	p.H20N		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	20										ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CCAGCCAGGTGTTTATCCATA	0.348			NA											47	43					6.3008e-33	1.07269e-32	0.00361	1	0
ACADM	34	broad.mit.edu	37	1	76199314	76199314	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:76199314G>T	uc001dgw.3	+	5	817	c.387_splice	c.e5+1	p.G129_splice	ACADM_uc010orc.1_Intron|ACADM_uc010ord.1_Splice_Site_p.G43_splice|ACADM_uc009wbp.2_Splice_Site_p.G133_splice|ACADM_uc009wbr.2_Splice_Site_p.G162_splice|ACADM_uc010ore.1_Splice_Site_p.G93_splice|ACADM_uc010orf.1_Intron|ACADM_uc001dgx.3_Splice_Site_p.G43_splice|ACADM_uc010org.1_Intron	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a						carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						TTCTTTGGGGGTAAGTGACTT	0.358			NA											12	41					0.00010058	0.000107352	0.001368	1	0
ACADM	34	broad.mit.edu	37	1	76211578	76211578	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:76211578A>T	uc001dgw.3	+	8	1117	c.687A>T	c.(685-687)CCA>CCT	p.P229P	ACADM_uc010ord.1_Silent_p.P143P|ACADM_uc009wbp.2_Silent_p.P233P|ACADM_uc009wbr.2_Silent_p.P262P|ACADM_uc010ore.1_Silent_p.P193P|ACADM_uc010orf.1_Silent_p.P40P|ACADM_uc001dgx.3_Silent_p.P143P|ACADM_uc010org.1_Silent_p.P99P|ACADM_uc009wbs.1_RNA	NM_000016	NP_000007	P11310	ACADM_HUMAN	medium-chain acyl-CoA dehydrogenase isoform a	229					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(2)|ovary(1)|skin(1)	4						CAGATACCCCAGGAATTCAGA	0.328			NA											50	31					0	0	0.00361	0	0
MSH4	4438	broad.mit.edu	37	1	76345744	76345744	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:76345744G>C	uc001dhd.1	+	13	1728	c.1687G>C	c.(1687-1689)GTG>CTG	p.V563L		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	563					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GATTTCTAAAGTGAAAAATTC	0.279			NA						MMR					14	9					0	0	0.001855	0	0
MSH4	4438	broad.mit.edu	37	1	76345766	76345766	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:76345766C>G	uc001dhd.1	+	13	1750	c.1709C>G	c.(1708-1710)ACA>AGA	p.T570R		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	570					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TACAGCTTTACATCAGCAGAT	0.269			NA						MMR					5	20					0	0	0.001168	0	0
MSH4	4438	broad.mit.edu	37	1	76347015	76347015	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:76347015G>T	uc001dhd.1	+	14	1907	c.1866G>T	c.(1864-1866)ATG>ATT	p.M622I		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	622					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TGCTGGATATGCTACTGTCAT	0.348			NA						MMR					26	29					1.74197e-06	1.94177e-06	0.00632	1	0
ASB17	127247	broad.mit.edu	37	1	76384776	76384776	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:76384776T>C	uc001dhe.1	-	3	889	c.749A>G	c.(748-750)TAC>TGC	p.Y250C	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	250	SOCS box.				intracellular signal transduction					ovary(1)	1						TGGATCTTTGTATCTTGTTGA	0.313			NA											7	27					0	0	0.001984	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77509947	77509947	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:77509947A>T	uc001dhi.2	+	3	495	c.320A>T	c.(319-321)CAC>CTC	p.H107L	ST6GALNAC5_uc010ori.1_Intron|ST6GALNAC5_uc009wbw.2_RNA	NM_030965	NP_112227	Q9BVH7	SIA7E_HUMAN	sialyltransferase 7E	107	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			pancreas(1)|skin(1)	2						CATCTGCTGCACAGTCGGCAA	0.622			NA											16	50					0	0	0.003163	0	0
IFI44L	10964	broad.mit.edu	37	1	79107475	79107475	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:79107475C>G	uc010oro.1	+	9	1519	c.1340C>G	c.(1339-1341)GCG>GGG	p.A447G	IFI44L_uc010orp.1_Missense_Mutation_p.A184G|IFI44L_uc010orq.1_Missense_Mutation_p.A184G	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	447						cytoplasm					0						ATTGAGAGAGCGTTACAGCCC	0.468			NA											79	86					0	0	0.00361	0	0
LPHN2	23266	broad.mit.edu	37	1	82409307	82409307	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:82409307G>T	uc001dit.3	+	6	1233	c.1052G>T	c.(1051-1053)GGA>GTA	p.G351V	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Missense_Mutation_p.G351V|LPHN2_uc001div.2_Missense_Mutation_p.G351V|LPHN2_uc009wcd.2_Missense_Mutation_p.G351V	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor	351	Extracellular (Potential).|Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TTAAACCGAGGAGAATATGTA	0.388			NA											27	79					2.12542e-12	2.70966e-12	0.00632	1	0
LPHN2	23266	broad.mit.edu	37	1	82450266	82450266	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:82450266G>T	uc001dit.3	+	19	3413	c.3232_splice	c.e19-1	p.V1078_splice	LPHN2_uc001dis.2_Intron|LPHN2_uc001diu.2_Splice_Site_p.V1078_splice|LPHN2_uc001div.2_Splice_Site_p.V1078_splice|LPHN2_uc009wcd.2_Splice_Site_p.V1078_splice|LPHN2_uc001diw.2_Splice_Site_p.V662_splice	NM_012302	NP_036434	O95490	LPHN2_HUMAN	latrophilin 2 precursor						neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			ovary(3)|lung(3)|breast(2)|central_nervous_system(1)	9				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		ATTCAATGCAGGTACGAAAAG	0.418			NA											15	36					8.60227e-14	1.12183e-13	0.004007	1	0
SYDE2	84144	broad.mit.edu	37	1	85655845	85655845	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:85655845C>A	uc009wcm.2	-	2	1385	c.1336G>T	c.(1336-1338)GCC>TCC	p.A446S	SYDE2_uc001dku.3_Missense_Mutation_p.A446S	NM_032184	NP_115560	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2	446					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|central_nervous_system(1)	2				all cancers(265;0.0126)|Epithelial(280;0.0336)		GTGGAATGGGCAGGATGTATA	0.453			NA											86	63					5.52753e-52	1.01138e-51	0.00361	1	0
CLCA4	22802	broad.mit.edu	37	1	87012922	87012922	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:87012922T>C	uc009wcs.2	+	1	164	c.120T>C	c.(118-120)CCT>CCC	p.P40P	CLCA4_uc009wct.2_5'UTR|CLCA4_uc009wcu.2_5'UTR	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	40						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTATAGATCCTAGTGTGCCAG	0.284			NA											23	28					0	0	0.00278	0	0
GBP2	2634	broad.mit.edu	37	1	89575510	89575510	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:89575510C>A	uc001dmz.1	-	10	1780	c.1509G>T	c.(1507-1509)ATG>ATT	p.M503I	GBP2_uc001dmy.1_RNA	NM_004120	NP_004111	P32456	GBP2_HUMAN	guanylate binding protein 2,	503					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)	1		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		TTTCCTCCAACATTTTCTTTG	0.373			NA											7	35					8.12818e-05	8.70909e-05	0.001984	1	0
GBP4	115361	broad.mit.edu	37	1	89654327	89654327	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:89654327A>G	uc001dnb.2	-	8	1464	c.1348T>C	c.(1348-1350)TAC>CAC	p.Y450H		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	450						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		TCTTCTAAGTAGAGATTGTGT	0.448			NA											143	336					0	0	0.00361	0	0
BARHL2	343472	broad.mit.edu	37	1	91182132	91182132	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:91182132G>T	uc001dns.2	-	1	663	c.621C>A	c.(619-621)TGC>TGA	p.C207*		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	207						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		ACTCACCGTGGCATTTGATGT	0.602	GBM(199;3561 4100 22440)		NA											11	45					6.40141e-05	6.88944e-05	0.000978	1	0
HFM1	164045	broad.mit.edu	37	1	91866637	91866637	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:91866637C>G	uc001doa.3	-	2	103	c.3G>C	c.(1-3)ATG>ATC	p.M1I	HFM1_uc010osu.1_5'UTR|HFM1_uc010osv.1_5'UTR|HFM1_uc001doc.1_Missense_Mutation_p.M1I	NM_001017975	NP_001017975	A2PYH4	HFM1_HUMAN	HFM1 protein	1							ATP binding|ATP-dependent helicase activity|nucleic acid binding				0		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		TTGATTTCAGCATTGTTGAAA	0.244			NA											6	15					0	0	0.001168	0	0
BRDT	676	broad.mit.edu	37	1	92470805	92470805	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:92470805A>C	uc001dok.3	+	18	3073	c.2724A>C	c.(2722-2724)AAA>AAC	p.K908N	BRDT_uc001dol.3_Missense_Mutation_p.K908N|BRDT_uc010osz.1_Missense_Mutation_p.K912N|BRDT_uc009wdf.2_Missense_Mutation_p.K835N|BRDT_uc010ota.1_Missense_Mutation_p.K862N|BRDT_uc010otb.1_Missense_Mutation_p.K862N|BRDT_uc001dom.3_Missense_Mutation_p.K908N	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	908					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GGCTTCTCAAAGACCGTGATT	0.363			NA											60	48					0	0	0.00361	0	0
EVI5	7813	broad.mit.edu	37	1	93201972	93201972	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:93201972T>A	uc001dox.2	-	2	274	c.264A>T	c.(262-264)AAA>AAT	p.K88N	EVI5_uc010otf.1_Missense_Mutation_p.K88N	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	88	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GTTCTTCCAGTTTAGCCAGGA	0.398			NA											28	21					0	0	0.00632	0	0
EVI5	7813	broad.mit.edu	37	1	93257926	93257926	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:93257926G>T	uc001dox.2	-	1	36	c.26C>A	c.(25-27)GCC>GAC	p.A9D	EVI5_uc010otf.1_Missense_Mutation_p.A9D	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	9	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GTTTCTAAAGGCAGCAGTCAT	0.333			NA											11	28					0.00136819	0.00142493	0.001368	1	0
LPPR4	9890	broad.mit.edu	37	1	99771894	99771894	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:99771894T>A	uc001dse.2	+	7	1726	c.1620T>A	c.(1618-1620)ACT>ACA	p.T540T	LPPR4_uc010oue.1_Silent_p.T482T	NM_014839	NP_055654	Q7Z2D5	LPPR4_HUMAN	plasticity related gene 1	540							phosphatidate phosphatase activity			ovary(3)	3		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CTGAGGAGACTCAGGAAAACA	0.557			NA											90	62					0	0	0.00361	0	0
AMY2A	279	broad.mit.edu	37	1	104160642	104160642	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:104160642C>G	uc001dut.2	+	2	299	c.235C>G	c.(235-237)CCA>GCA	p.P79A	AMY2A_uc010ouq.1_Missense_Mutation_p.P79A	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	79					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	AAGATACCAACCAGTTAGCTA	0.353			NA											30	70					0	0	0.009535	0	0
NTNG1	22854	broad.mit.edu	37	1	107691462	107691462	+	Splice_Site	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:107691462G>C	uc001dvh.3	+	2	964	c.246_splice	c.e2+1	p.M82_splice	NTNG1_uc001dvf.3_Splice_Site_p.M82_splice|NTNG1_uc010out.1_Splice_Site_p.M82_splice|NTNG1_uc001dvc.3_Splice_Site_p.M82_splice|NTNG1_uc001dvd.1_Splice_Site_p.M82_splice	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1						axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CTGTGCAATGGTGAGGTAACC	0.423			NA											18	40					0	0	0.006122	0	0
NTNG1	22854	broad.mit.edu	37	1	107937821	107937821	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:107937821C>A	uc001dvh.3	+	4	1651	c.933C>A	c.(931-933)AGC>AGA	p.S311R	NTNG1_uc001dvf.3_Missense_Mutation_p.S311R|NTNG1_uc010out.1_Missense_Mutation_p.S311R|NTNG1_uc001dvc.3_Missense_Mutation_p.S311R|NTNG1_uc001dvi.2_5'UTR|NTNG1_uc001dve.2_RNA|NTNG1_uc009wek.2_RNA|NTNG1_uc001dvg.2_RNA|NTNG1_uc009wem.2_5'UTR|NTNG1_uc001dvd.1_Missense_Mutation_p.S311R	NM_001113226	NP_001106697	Q9Y2I2	NTNG1_HUMAN	netrin G1 isoform 1	311	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane	protein binding			large_intestine(2)|ovary(2)|skin(2)	6		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		ATGACAACAGCAAATTGACAT	0.478			NA											44	70					1.61863e-15	2.19525e-15	0.00361	1	0
VAV3	10451	broad.mit.edu	37	1	108138931	108138931	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:108138931G>T	uc001dvk.1	-	25	2307	c.2253C>A	c.(2251-2253)CTC>CTA	p.L751L	VAV3_uc010ouu.1_Silent_p.L155L|VAV3_uc001dvj.1_Silent_p.L191L|VAV3_uc010ouv.1_Silent_p.L155L|VAV3_uc010ouw.1_Silent_p.L751L	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	751	SH2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		ACCCTTCCTTGAGAGAATGAT	0.408			NA											22	42					2.37509e-13	3.07458e-13	0.010504	1	0
VAV3	10451	broad.mit.edu	37	1	108313319	108313319	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:108313319C>G	uc001dvk.1	-	6	641	c.587G>C	c.(586-588)TGT>TCT	p.C196S	VAV3_uc010ouw.1_Missense_Mutation_p.C196S|VAV3_uc001dvl.1_Missense_Mutation_p.C20S|VAV3_uc010oux.1_Missense_Mutation_p.C196S	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	196	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTCTGCTAGACAACAACTTCG	0.299			NA											15	36					0	0	0.004007	0	0
CELSR2	1952	broad.mit.edu	37	1	109792961	109792961	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:109792961A>G	uc001dxa.3	+	1	321	c.260A>G	c.(259-261)CAC>CGC	p.H87R		NM_001408	NP_001399	Q9HCU4	CELR2_HUMAN	cadherin EGF LAG seven-pass G-type receptor 2	87	Extracellular (Potential).				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(4)|lung(3)|skin(1)	8		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTACCCCACCACGATGGCCTG	0.632	NSCLC(158;1285 2011 34800 34852 42084)		NA											40	48					0	0	0.004878	0	0
UBL4B	164153	broad.mit.edu	37	1	110655547	110655547	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:110655547G>T	uc001dzc.2	+	1	486	c.391G>T	c.(391-393)GAG>TAG	p.E131*		NM_203412	NP_981957	Q8N7F7	UBL4B_HUMAN	ubiquitin-like 4B	131						cytoplasm				ovary(1)	1		all_cancers(81;1.14e-05)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0236)|all cancers(265;0.0823)|Epithelial(280;0.0917)|Colorectal(144;0.109)|LUSC - Lung squamous cell carcinoma(189;0.134)		GGAGCACCTGGAGCAGCTGGC	0.612			NA											6	9					0.00116845	0.00121886	0.001168	1	0
KCND3	3752	broad.mit.edu	37	1	112524472	112524472	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:112524472G>A	uc001ebu.1	-	2	1357	c.877C>T	c.(877-879)CGC>TGC	p.R293C	KCND3_uc001ebv.1_Missense_Mutation_p.R293C	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	293	Helical; Voltage-sensor; Name=Segment S4; (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CTGAAGACGCGGAAGACCCGG	0.587			NA											20	29					0	0	0.008871	0	0
WNT2B	7482	broad.mit.edu	37	1	113058873	113058873	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:113058873C>A	uc001ecb.2	+	3	1030	c.515C>A	c.(514-516)ACC>AAC	p.T172N	WNT2B_uc001eca.2_Missense_Mutation_p.T153N|WNT2B_uc009wgg.2_Missense_Mutation_p.T80N	NM_024494	NP_078613	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family,	172					chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			ovary(2)|breast(2)|skin(1)	5	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GACCCCTACACCCGTGGCCGA	0.577			NA											37	62					1.59361e-14	2.10522e-14	0.006999	1	0
PTPN22	26191	broad.mit.edu	37	1	114377049	114377049	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:114377049G>A	uc001eds.2	-	15	2037	c.1907C>T	c.(1906-1908)CCA>CTA	p.P636L	PTPN22_uc009wgq.2_Missense_Mutation_p.P581L|PTPN22_uc010owo.1_Missense_Mutation_p.P392L|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.P636L|PTPN22_uc009wgs.2_Missense_Mutation_p.P509L|PTPN22_uc001edu.2_Missense_Mutation_p.P636L	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	636					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGGAACATTTGGTGAGAATTC	0.358			NA											30	48					0	0	0.002836	0	0
AP4B1	10717	broad.mit.edu	37	1	114442706	114442706	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:114442706T>A	uc001eeb.2	-	5	1077	c.934A>T	c.(934-936)AGC>TGC	p.S312C	uc001edv.1_RNA|AP4B1_uc001eec.2_Missense_Mutation_p.S144C|AP4B1_uc001eed.2_Missense_Mutation_p.S312C|AP4B1_uc010owp.1_Missense_Mutation_p.S213C|AP4B1_uc001eea.1_Missense_Mutation_p.S106C|AP4B1_uc001eee.1_5'Flank|AP4B1_uc010owq.1_Missense_Mutation_p.S219C	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	312					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TAGTGGCTGCTAAAGTGACCT	0.468			NA											64	78					0	0	0.00361	0	0
HIPK1	204851	broad.mit.edu	37	1	114499307	114499307	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:114499307G>T	uc001eem.2	+	6	1627	c.1466G>T	c.(1465-1467)AGA>ATA	p.R489I	HIPK1_uc001eel.2_Missense_Mutation_p.R489I|HIPK1_uc001een.2_Missense_Mutation_p.R489I|HIPK1_uc001eeo.2_Missense_Mutation_p.R115I|HIPK1_uc001eep.2_Missense_Mutation_p.R95I	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	489	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGACCGAAGAGAATACATT	0.378			NA											14	16					0.00244969	0.00253897	0.00245	1	0
IGSF3	3321	broad.mit.edu	37	1	117146412	117146412	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:117146412C>G	uc001egr.1	-	6	2163	c.1458G>C	c.(1456-1458)ATG>ATC	p.M486I	IGSF3_uc001egq.1_Missense_Mutation_p.M506I|IGSF3_uc001egs.1_Missense_Mutation_p.M159I	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	486	Ig-like C2-type 4.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GCACCTGCTCCATCTGGACGC	0.617			NA											22	26					0	0	0.002299	0	0
IGSF3	3321	broad.mit.edu	37	1	117158852	117158852	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:117158852C>G	uc001egr.1	-	3	976	c.271G>C	c.(271-273)GGG>CGG	p.G91R	IGSF3_uc001egq.1_Missense_Mutation_p.G91R	NM_001007237	NP_001007238	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3 isoform 2	91	Ig-like C2-type 1.|Extracellular (Potential).					integral to membrane				ovary(2)	2	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		AAGATCTTCCCTCCGCGGACG	0.567			NA											10	19					0	0	0.006214	0	0
TBX15	6913	broad.mit.edu	37	1	119441667	119441667	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:119441667G>T	uc001ehl.1	-	7	1005	c.690C>A	c.(688-690)ACC>ACA	p.T230T	TBX15_uc009whj.1_Silent_p.T21T	NM_152380	NP_689593	Q96SF7	TBX15_HUMAN	T-box 15	336						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|pancreas(1)	2	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GCTTCTGCATGGTGGTGAAGT	0.527			NA											18	33					2.5808e-16	3.5525e-16	0.006122	1	0
NBPF7	343505	broad.mit.edu	37	1	120384152	120384152	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:120384152C>T	uc010oxk.1	-	3	1031	c.410G>A	c.(409-411)AGA>AAA	p.R137K		NM_001047980	NP_001041445	P0C2Y1	NBPF7_HUMAN	hypothetical protein LOC343505	137	Potential.					cytoplasm				ovary(1)|skin(1)	2	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;3.66e-05)|Lung NSC(69;0.000192)|all_epithelial(167;0.0347)		Lung(183;0.0103)|LUSC - Lung squamous cell carcinoma(189;0.0544)		GGAGGCATCTCTCCCTTCCCG	0.498			NA											66	128					0	0	0.00361	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882701	144882701	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:144882701C>A	uc001elw.3	-	24	3609	c.3318G>T	c.(3316-3318)CAG>CAT	p.Q1106H	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.Q113H	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1106	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCAGTTTTCCCTGGAGCTTTC	0.478			NA	T	PDGFRB	MPD								38	222					2.52637e-11	3.16042e-11	0.005524	1	0
NOTCH2NL	388677	broad.mit.edu	37	1	145273203	145273203	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:145273203G>T	uc001emn.3	+	3	427	c.57G>T	c.(55-57)TTG>TTT	p.L19F	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Missense_Mutation_p.L19F|NOTCH2NL_uc001emo.2_Missense_Mutation_p.L19F|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	19	EGF-like 1.			L -> S (in Ref. 1; BAC11381).	cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						AAGGCTTCTTGGGGGAATATT	0.473			NA											14	79					6.49762e-13	8.33315e-13	0.006122	1	0
NOTCH2NL	388677	broad.mit.edu	37	1	145281550	145281550	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:145281550C>T	uc001emn.3	+	4	850	c.480C>T	c.(478-480)CTC>CTT	p.L160L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Silent_p.L160L|NOTCH2NL_uc001emo.2_Silent_p.L160L|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	160	EGF-like 5; calcium-binding (Potential).				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						GCACCTGCCTCAACCTGCCTG	0.562			NA											15	185					0	0	0.004007	0	0
NBPF10	100132406	broad.mit.edu	37	1	145299852	145299852	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:145299852G>A	uc001end.3	+	6	936	c.901G>A	c.(901-903)GAG>AAG	p.E301K	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Missense_Mutation_p.E301K|NBPF10_uc010oyi.1_5'Flank|NBPF10_uc001emq.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	301											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CCAGCTGGCAGAGAAGAAACA	0.463			NA											18	621					0	0	0.00361	0	0
GJA8	2703	broad.mit.edu	37	1	147381061	147381061	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:147381061G>T	uc001epu.1	+	2	1042	c.979G>T	c.(979-981)GGG>TGG	p.G327W		NM_005267	NP_005258	P48165	CXA8_HUMAN	connexin 50	327	Cytoplasmic (Potential).				cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.0276)					CGCTCAGGTGGGGGCACAAGA	0.622	Melanoma(76;1255 1795 8195 52096)		NA											8	13					0.00307968	0.00318168	0.00308	1	0
LOC200030	200030	broad.mit.edu	37	1	148344650	148344650	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:148344650C>T	uc001eqf.2	-	2	303	c.268G>A	c.(268-270)GAG>AAG	p.E90K	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqg.2_Intron|NBPF14_uc009wkf.1_Intron|uc001erd.3_Missense_Mutation_p.E90K|uc001erc.3_Intron|uc010paj.1_Intron|uc010pau.1_5'Flank|uc010pav.1_Missense_Mutation_p.E90K|uc010paw.1_Intron	NM_017940	NP_060410	Q86T75	NBPFB_HUMAN	hypothetical protein LOC55672	90	Potential.					cytoplasm					0						CTGAGCTCCTCAGCTTGCTTG	0.517			NA											99	563					0	0	0.00361	0	0
SV2A	9900	broad.mit.edu	37	1	149878336	149878336	+	Missense_Mutation	SNP	G	G	T	rs149927876		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:149878336G>T	uc001etg.2	-	11	2242	c.1751C>A	c.(1750-1752)CCG>CAG	p.P584Q	SV2A_uc009wlk.2_Missense_Mutation_p.P36Q|SV2A_uc001eth.2_Missense_Mutation_p.P584Q	NM_014849	NP_055664	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2	584	Extracellular (Potential).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(6)|pancreas(1)	7	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CACGTCTAGCGGGCAGCCCTC	0.542			NA											21	26					5.26018e-13	6.76409e-13	0.001882	1	0
ECM1	1893	broad.mit.edu	37	1	150483557	150483557	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:150483557G>A	uc001eus.2	+	6	790	c.591G>A	c.(589-591)CAG>CAA	p.Q197Q	ECM1_uc010pce.1_Silent_p.Q126Q|ECM1_uc010pcf.1_Silent_p.Q119Q|ECM1_uc001eut.2_Silent_p.Q197Q|ECM1_uc001euu.2_Silent_p.Q226Q|ECM1_uc001euv.2_Silent_p.Q224Q|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	197	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			ACCTACCACAGTCCAGCTACT	0.572	Melanoma(156;1696 2560 11093 19685)		NA											88	102					0	0	0.00361	0	0
HRNR	388697	broad.mit.edu	37	1	152191134	152191134	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152191134G>C	uc001ezt.1	-	3	3047	c.2971C>G	c.(2971-2973)CGT>GGT	p.R991G		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	991	11.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAAGACTGACGGGAGCCAGAC	0.582			NA											111	153					0	0	0.00361	0	0
HRNR	388697	broad.mit.edu	37	1	152191741	152191741	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152191741G>A	uc001ezt.1	-	3	2440	c.2364C>T	c.(2362-2364)TCC>TCT	p.S788S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	788	8.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGTGGCTGGAGGAGTGCCCTG	0.602			NA											36	37					0	0	0.003755	0	0
HRNR	388697	broad.mit.edu	37	1	152192435	152192435	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152192435C>A	uc001ezt.1	-	3	1746	c.1670G>T	c.(1669-1671)AGC>ATC	p.S557I		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	557	5.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGCCATAGCTGGAAGACTG	0.587			NA											83	134					3.76054e-38	6.5699e-38	0.00361	1	0
FLG	2312	broad.mit.edu	37	1	152277418	152277418	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152277418T>G	uc001ezu.1	-	3	9980	c.9944A>C	c.(9943-9945)CAC>CCC	p.H3315P		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3315	Filaggrin 20.|Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AATGCCTGAGTGTCTGGAGCT	0.557			NA							Ichthyosis				197	364					0	0	0.00361	0	0
FLG	2312	broad.mit.edu	37	1	152281867	152281867	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152281867G>C	uc001ezu.1	-	3	5531	c.5495C>G	c.(5494-5496)TCG>TGG	p.S1832W		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1832	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTATCTACCGATTGCTCATA	0.577			NA							Ichthyosis				173	259					0	0	0.00361	0	0
FLG2	388698	broad.mit.edu	37	1	152323648	152323648	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152323648C>A	uc001ezw.3	-	3	6687	c.6614G>T	c.(6613-6615)GGA>GTA	p.G2205V	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2205							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGTCGAGATCCGGCTTGGCT	0.507			NA											116	207					2.08041e-53	3.821e-53	0.00361	1	0
FLG2	388698	broad.mit.edu	37	1	152328422	152328422	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152328422C>A	uc001ezw.3	-	3	1913	c.1840G>T	c.(1840-1842)GGT>TGT	p.G614C	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	614	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTAGACTGACCTGATCTAGAC	0.512			NA											149	213					2.0701e-58	3.82752e-58	0.00361	1	0
KPRP	448834	broad.mit.edu	37	1	152732973	152732973	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152732973C>G	uc001fal.1	+	2	967	c.909C>G	c.(907-909)CCC>CCG	p.P303P		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	303	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCTGAACCCATATATAACA	0.597			NA											15	46					0	0	0.010504	0	0
KPRP	448834	broad.mit.edu	37	1	152733137	152733137	+	Missense_Mutation	SNP	G	G	C	rs150376386	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:152733137G>C	uc001fal.1	+	2	1131	c.1073G>C	c.(1072-1074)GGC>GCC	p.G358A		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	358	Pro-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGAGCTGTGGCCCGCAGCCC	0.647			NA											27	36					0	0	0.004656	0	0
SPRR2F	6705	broad.mit.edu	37	1	153085207	153085207	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:153085207C>G	uc001fbi.2	-	2	62	c.3G>C	c.(1-3)ATG>ATC	p.M1I	SPRR2D_uc009wnz.2_Intron|SPRR2A_uc001fbf.2_Intron|SPRR2A_uc009woa.2_Intron	NM_001014450	NP_001014450	Q96RM1	SPR2F_HUMAN	small proline-rich protein 2F	1					keratinization	cornified envelope|cytoplasm					0	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTTGATAAGACATCCTGCTGG	0.542			NA											33	51					0	0	0.003271	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122509	153122509	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:153122509T>A	uc009wod.1	-	2	199	c.78A>T	c.(76-78)CCA>CCT	p.P26P		NM_001014291	NP_001014313	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	26	1.|3 X 9 AA approximate tandem repeats.				keratinization	cornified envelope|cytoplasm					0	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGGTGGACATGGCTCTGGGC	0.597			NA											30	51					0	0	0.002836	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122550	153122550	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:153122550G>T	uc009wod.1	-	2	158	c.37C>A	c.(37-39)CAG>AAG	p.Q13K		NM_001014291	NP_001014313	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	13					keratinization	cornified envelope|cytoplasm					0	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAGGTGGCTGGCAGGGCTGC	0.562			NA											26	47					3.99451e-17	5.57789e-17	0.009535	1	0
PGLYRP4	57115	broad.mit.edu	37	1	153309735	153309735	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:153309735C>G	uc001fbo.2	-	8	930	c.865G>C	c.(865-867)GGC>CGC	p.G289R	PGLYRP4_uc001fbp.2_Missense_Mutation_p.G285R	NM_020393	NP_065126	Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein-I-beta	289					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)|skin(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACATTCCAGCCCACCCCTTCA	0.532			NA											11	25					0	0	0.008291	0	0
C1orf77	26097	broad.mit.edu	37	1	153617542	153617542	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:153617542C>T	uc001fcm.1	+	6	856	c.544C>T	c.(544-546)CGG>TGG	p.R182W	C1orf77_uc001fcn.1_Missense_Mutation_p.R183W|C1orf77_uc001fco.1_Missense_Mutation_p.R157W|C1orf77_uc001fcp.2_RNA	NM_015607	NP_056422	Q9Y3Y2	CHTOP_HUMAN	small protein rich in arginine and glycine	182	Arg/Gly-rich.|Interaction with PRMT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	protein binding|RNA binding				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGGGCCAGGTCGGGGTATGAT	0.542			NA											19	30					0	0	0.008871	0	0
PBXIP1	57326	broad.mit.edu	37	1	154920025	154920025	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:154920025C>A	uc001ffr.2	-	9	798	c.739_splice	c.e9-1	p.D247_splice	PBXIP1_uc001ffs.2_Splice_Site_p.D218_splice|PBXIP1_uc010pep.1_Splice_Site_p.D92_splice	NM_020524	NP_065385	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein						cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			large_intestine(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTAGCCCATCCTGAGGGCAGA	0.602			NA											32	50					2.85442e-18	4.08015e-18	0.002096	1	0
ASH1L	55870	broad.mit.edu	37	1	155448036	155448036	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:155448036T>G	uc009wqq.2	-	3	5105	c.4625A>C	c.(4624-4626)CAT>CCT	p.H1542P	ASH1L_uc001fkt.2_Missense_Mutation_p.H1542P|ASH1L_uc009wqr.1_Missense_Mutation_p.H1542P	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1542					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			AGGAGAGAGATGAGGGCAGGA	0.458			NA											34	59					0	0	0.005524	0	0
SYT11	23208	broad.mit.edu	37	1	155838079	155838079	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:155838079G>T	uc001fmg.2	+	2	621	c.358G>T	c.(358-360)GAC>TAC	p.D120Y	SYT11_uc010pgq.1_Intron	NM_152280	NP_689493	Q9BT88	SYT11_HUMAN	synaptotagmin XI	120	Cytoplasmic (Potential).					cell junction|synaptic vesicle membrane	protein binding|transporter activity			ovary(1)|skin(1)	2	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			ATCTTGTATAGACCAATTACC	0.537			NA											44	66					5.20837e-25	8.25655e-25	0.00874	1	0
SLC25A44	9673	broad.mit.edu	37	1	156169978	156169978	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:156169978G>T	uc001fnp.2	+	2	662	c.340G>T	c.(340-342)GTG>TTG	p.V114L	SLC25A44_uc010phc.1_Intron|SLC25A44_uc009wrr.2_Missense_Mutation_p.V114L|SLC25A44_uc010phd.1_Intron|SLC25A44_uc010phe.1_Intron	NM_014655	NP_055470	Q96H78	S2544_HUMAN	solute carrier family 25, member 44	114	Solcar 2.|Helical; Name=3; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1	Hepatocellular(266;0.158)					CAAATCACTGGTGGCTGGTGG	0.527			NA											24	24					2.44723e-14	3.22188e-14	0.004656	1	0
SH2D2A	9047	broad.mit.edu	37	1	156779009	156779009	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:156779009C>A	uc001fqd.2	-	7	1128	c.988G>T	c.(988-990)GTC>TTC	p.V330F	SH2D2A_uc001fqc.1_Missense_Mutation_p.V302F|SH2D2A_uc009wsh.2_Missense_Mutation_p.V340F|SH2D2A_uc001fqe.2_Missense_Mutation_p.V312F|SH2D2A_uc010phs.1_Missense_Mutation_p.V330F	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	330	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCTCCTGGGACAGGCCTGGAC	0.587			NA											60	115					2.17656e-39	3.84075e-39	0.00361	1	0
FCRL1	115350	broad.mit.edu	37	1	157772359	157772359	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:157772359C>A	uc001frg.2	-	4	528	c.415G>T	c.(415-417)GGC>TGC	p.G139C	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Missense_Mutation_p.G139C|FCRL1_uc001fri.2_Missense_Mutation_p.G139C|FCRL1_uc001frj.2_Intron	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	139	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TCTCCTGTGCCCATAGCAACT	0.542	GBM(54;482 1003 11223 30131 35730)		NA											18	26					2.48551e-13	3.21321e-13	0.00499	1	0
FCRL1	115350	broad.mit.edu	37	1	157772447	157772447	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:157772447A>G	uc001frg.2	-	4	440	c.327T>C	c.(325-327)CCT>CCC	p.P109P	FCRL1_uc001frf.2_5'Flank|FCRL1_uc001frh.2_Silent_p.P109P|FCRL1_uc001fri.2_Silent_p.P109P|FCRL1_uc001frj.2_RNA	NM_052938	NP_443170	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1 isoform 1 precursor	109	Ig-like C2-type 2.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			skin(4)|ovary(3)	7	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CATCAGCGACAGGGACCCCTG	0.537	GBM(54;482 1003 11223 30131 35730)		NA											5	9					0	0	0.001168	0	0
CD1C	911	broad.mit.edu	37	1	158261039	158261039	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:158261039C>G	uc001fru.2	+	2	469	c.177C>G	c.(175-177)GAC>GAG	p.D59E	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	59	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					ATGGCTGGGACAGTGAATCAG	0.478			NA											20	37					0	0	0.008871	0	0
CD1C	911	broad.mit.edu	37	1	158262139	158262139	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:158262139G>T	uc001fru.2	+	3	886	c.594G>T	c.(592-594)ATG>ATT	p.M198I	CD1C_uc001frv.2_Missense_Mutation_p.M1I	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	198	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding	p.M198I(1)		ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					CAGGGAAGATGTATGTACACA	0.453			NA											85	154					6.31949e-53	1.15957e-52	0.00361	1	0
CD1E	913	broad.mit.edu	37	1	158324271	158324272	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:158324271_158324272GG>TT	uc001fse.2	+	2	402_403	c.163_164GG>TT	c.(163-165)GGC>TTC	p.G55F	CD1E_uc010pid.1_Missense_Mutation_p.G53F|CD1E_uc010pie.1_Intron|CD1E_uc010pif.1_Intron|CD1E_uc001fsd.2_Missense_Mutation_p.G55F|CD1E_uc001fsk.2_Missense_Mutation_p.G55F|CD1E_uc001fsj.2_Missense_Mutation_p.G55F|CD1E_uc001fsc.2_Intron|CD1E_uc010pig.1_Intron|CD1E_uc001fsa.2_Intron|CD1E_uc001fsf.2_Missense_Mutation_p.G55F|CD1E_uc001fry.2_Missense_Mutation_p.G55F|CD1E_uc001fsg.2_Intron|CD1E_uc001fsh.2_Intron|CD1E_uc001fsi.2_Missense_Mutation_p.G55F|CD1E_uc009wsv.2_Intron|CD1E_uc001frz.2_Missense_Mutation_p.G55F|CD1E_uc009wsw.2_5'Flank	NM_030893	NP_112155	P15812	CD1E_HUMAN	CD1E antigen isoform a precursor	55					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				skin(3)	3	all_hematologic(112;0.0378)					ACACAGTGAGGGCTCAGGATGG	0.569			NA											29	35					0	0	0.004672	0	0
SPTA1	6708	broad.mit.edu	37	1	158609374	158609374	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:158609374C>G	uc001fst.1	-	35	5177	c.4978G>C	c.(4978-4980)GAG>CAG	p.E1660Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1660	Spectrin 16.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					CTACTTACCTCTCGAGCCAAC	0.483			NA											34	55					0	0	0.004289	0	0
MNDA	4332	broad.mit.edu	37	1	158815556	158815556	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:158815556A>T	uc001fsz.1	+	5	950	c.750A>T	c.(748-750)AAA>AAT	p.K250N		NM_002432	NP_002423	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	250	HIN-200.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(2)|skin(2)	4	all_hematologic(112;0.0378)					TCCATGTGAAAGTCTTCGACA	0.373			NA											7	17					0	0	0.00308	0	0
PYHIN1	149628	broad.mit.edu	37	1	158914788	158914788	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:158914788C>T	uc001ftb.2	+	7	1560	c.1315C>T	c.(1315-1317)CCT>TCT	p.P439S	PYHIN1_uc001ftc.2_Missense_Mutation_p.P430S|PYHIN1_uc001ftd.2_Missense_Mutation_p.P439S|PYHIN1_uc001fte.2_Missense_Mutation_p.P430S	NM_152501	NP_689714	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1 alpha 1	439					cell cycle	nuclear speck				ovary(3)|pancreas(1)	4	all_hematologic(112;0.0378)					TCTCAAGACTCCTCAGATGCC	0.493			NA											39	61					0	0	0.002522	0	0
DARC	2532	broad.mit.edu	37	1	159175667	159175667	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:159175667G>T	uc001fto.2	+	2	678	c.438G>T	c.(436-438)CTG>CTT	p.L146L	DARC_uc001ftp.3_Silent_p.L148L	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	146	Helical; Name=3; (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					AGGCTTTGCTGCTAGGGTGCC	0.647			NA											7	15					8.12818e-05	8.70909e-05	0.001984	1	0
OR10J3	441911	broad.mit.edu	37	1	159283519	159283519	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:159283519C>A	uc010piu.1	-	1	931	c.931G>T	c.(931-933)GTC>TTC	p.V311F		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	311	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					ATTAAGGAGACAGAGTTTTTT	0.423			NA											24	35					2.98393e-07	3.40668e-07	0.00278	1	0
KCNJ9	3765	broad.mit.edu	37	1	160057416	160057416	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:160057416C>A	uc001fuy.1	+	3	1233	c.991C>A	c.(991-993)CCT>ACT	p.P331T		NM_004983	NP_004974	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel subfamily	331	Cytoplasmic (By similarity).				synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			ovary(1)|skin(1)	2	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GGTGCCCACACCTTCGTGCAG	0.572			NA											24	47					4.4004e-07	4.97101e-07	0.00333	1	0
FCGR2A	2212	broad.mit.edu	37	1	161479826	161479826	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:161479826C>A	uc001gan.2	+	4	634	c.581C>A	c.(580-582)ACG>AAG	p.T194K	FCGR2A_uc001gam.2_Missense_Mutation_p.T193K|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	194	Extracellular (Potential).|Ig-like C2-type 2.					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ATAGGCTACACGCTGTTCTCA	0.517			NA											25	39					2.98393e-07	3.40668e-07	0.00278	1	0
SH2D1B	117157	broad.mit.edu	37	1	162381686	162381686	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:162381686A>G	uc001gbz.1	-	1	243	c.121T>C	c.(121-123)TGC>CGC	p.C41R	SH2D1B_uc001gca.1_Missense_Mutation_p.C41R	NM_053282	NP_444512	O14796	SH21B_HUMAN	SH2 domain containing 1B	41	SH2.									pancreas(1)	1	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			ACACAGAGGCACAGGACTCCT	0.502			NA											15	41					0	0	0.004007	0	0
PBX1	5087	broad.mit.edu	37	1	164532548	164532548	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:164532548G>T	uc001gct.2	+	2	523	c.265G>T	c.(265-267)GTT>TTT	p.V89F	PBX1_uc010pku.1_Missense_Mutation_p.V89F|PBX1_uc010pkv.1_Intron|PBX1_uc001gcs.2_Missense_Mutation_p.V89F	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	89		Breakpoint for translocation to form CAA67062A-PBX1 oncogene.			negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						AGAAAAAACAGGTAGGAATGA	0.313			NA	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								23	43					7.87624e-14	1.02854e-13	0.00278	1	0
DUSP27	92235	broad.mit.edu	37	1	167095752	167095752	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:167095752C>A	uc001geb.1	+	5	1384	c.1384C>A	c.(1384-1386)CAC>AAC	p.H462N		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	462					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CCGCCCGGACCACGGCAGGAG	0.672			NA											6	6					8.12818e-05	8.70909e-05	0.001984	1	0
DUSP27	92235	broad.mit.edu	37	1	167096456	167096456	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:167096456G>C	uc001geb.1	+	5	2088	c.2088G>C	c.(2086-2088)GCG>GCC	p.A696A		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	696					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						GCAACATAGCGGGGTGTTCAA	0.597			NA											13	23					0	0	0.001855	0	0
DUSP27	92235	broad.mit.edu	37	1	167096930	167096930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:167096930C>A	uc001geb.1	+	5	2562	c.2562C>A	c.(2560-2562)TAC>TAA	p.Y854*		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	854					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						TGTCTGAGTACAAAATGGAAA	0.498			NA											19	15					6.94344e-10	8.39814e-10	0.006122	1	0
DUSP27	92235	broad.mit.edu	37	1	167097651	167097651	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:167097651T>A	uc001geb.1	+	5	3283	c.3283T>A	c.(3283-3285)TCT>ACT	p.S1095T		NM_001080426	NP_001073895	Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27	1095					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			ovary(3)	3						CTTTATGAGGTCTGAAGAAGA	0.517			NA											11	8					0	0	0.008291	0	0
CD247	919	broad.mit.edu	37	1	167407857	167407857	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:167407857C>A	uc001gei.3	-	4	395	c.250G>T	c.(250-252)GAT>TAT	p.D84Y	CD247_uc001gej.3_Missense_Mutation_p.D84Y|CD247_uc001gek.2_Missense_Mutation_p.D84Y	NM_198053	NP_932170	P20963	CD3Z_HUMAN	T-cell receptor zeta chain isoform 1 precursor	84	Cytoplasmic (Potential).|ITAM 1.				interspecies interaction between organisms|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytoplasm|integral to membrane	protein homodimerization activity|transmembrane receptor activity				0			LUSC - Lung squamous cell carcinoma(543;0.236)			TCCAAAACATCGTACTCCTCT	0.552	Ovarian(192;1815 2869 36877 43334)		NA											50	73					6.08268e-21	9.1193e-21	0.00361	1	0
C1orf156	92342	broad.mit.edu	37	1	169762469	169762469	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:169762469C>A	uc001ggn.2	-	2	646	c.368G>T	c.(367-369)GGT>GTT	p.G123V	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank|C1orf112_uc009wvt.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	123						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGCTGGAAACCTGGTAATGT	0.373			NA											20	26					5.03518e-11	6.25436e-11	0.007413	1	0
C1orf105	92346	broad.mit.edu	37	1	172431345	172431345	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:172431345G>T	uc001gik.2	+	5	497	c.301G>T	c.(301-303)GAT>TAT	p.D101Y		NM_139240	NP_640333	O95561	CA105_HUMAN	hypothetical protein LOC92346	101										skin(1)	1						GAAAATCCCAGATGATCCAAA	0.333			NA											5	6					0.000602214	0.000632636	0.000602	1	0
TNN	63923	broad.mit.edu	37	1	175046647	175046647	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:175046647C>T	uc001gkl.1	+	2	206	c.93C>T	c.(91-93)CCC>CCT	p.P31P	TNN_uc010pmx.1_Silent_p.P31P	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	31					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGGAGCCTCCCGGCTGCAGCA	0.602			NA											14	31					0	0	0.00499	0	0
TNR	7143	broad.mit.edu	37	1	175335228	175335228	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:175335228G>T	uc001gkp.1	-	9	2181	c.2100C>A	c.(2098-2100)ACC>ACA	p.T700T	TNR_uc009wwu.1_Silent_p.T700T	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	700	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GGGAGATGGAGGTCTCCGAGG	0.532			NA											18	31					1.56452e-12	1.99722e-12	0.007413	1	0
TNR	7143	broad.mit.edu	37	1	175360441	175360441	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:175360441G>C	uc001gkp.1	-	5	1571	c.1490C>G	c.(1489-1491)TCG>TGG	p.S497W	TNR_uc009wwu.1_Missense_Mutation_p.S497W	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	497	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					GACGCTGGCCGAGGTAGGGGG	0.547			NA											27	41					0	0	0.009535	0	0
RFWD2	64326	broad.mit.edu	37	1	175957423	175957423	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:175957423C>A	uc001gku.1	-	17	2228	c.1972_splice	c.e17+1	p.G658_splice	RFWD2_uc001gkv.1_Splice_Site_p.G634_splice|RFWD2_uc001gkw.1_Splice_Site_p.G418_splice|RFWD2_uc009wwv.2_Splice_Site_p.G457_splice|RFWD2_uc001gkt.1_Splice_Site_p.G497_splice	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a						DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						GTTTCACTTACCACAAGCTAT	0.368	Ovarian(134;1413 1765 5706 35534 51541)		NA											8	12					0.00448238	0.00462343	0.004482	1	0
PAPPA2	60676	broad.mit.edu	37	1	176563668	176563668	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:176563668G>T	uc001gkz.2	+	3	2092	c.928G>T	c.(928-930)GAT>TAT	p.D310Y	PAPPA2_uc001gky.1_Missense_Mutation_p.D310Y|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	310					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGGTGTGTTTGATAACTGCTC	0.507			NA											6	17					0.00116845	0.00121886	0.001168	1	0
ASTN1	460	broad.mit.edu	37	1	176852122	176852122	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:176852122G>A	uc001glc.2	-	20	3447	c.3235C>T	c.(3235-3237)CTG>TTG	p.L1079L	ASTN1_uc001glb.1_Silent_p.L1079L|ASTN1_uc001gld.1_Silent_p.L1079L	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1087	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						ACAAAGCTCAGCACTGTTTCT	0.483			NA											13	37					0	0	0.001368	0	0
ASTN1	460	broad.mit.edu	37	1	176903322	176903322	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:176903322C>G	uc001glc.2	-	16	2849	c.2637G>C	c.(2635-2637)CGG>CGC	p.R879R	ASTN1_uc001glb.1_Silent_p.R879R|ASTN1_uc001gld.1_Silent_p.R879R	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	887					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GCCAGAGTCGCCGCTGGACCT	0.502			NA											22	33					0	0	0.003954	0	0
ASTN1	460	broad.mit.edu	37	1	176993767	176993767	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:176993767G>T	uc001glc.2	-	6	1434	c.1222C>A	c.(1222-1224)CTC>ATC	p.L408I	ASTN1_uc001glb.1_Missense_Mutation_p.L408I|ASTN1_uc001gld.1_Missense_Mutation_p.L408I|ASTN1_uc009wwx.1_Missense_Mutation_p.L408I|ASTN1_uc001gle.3_RNA	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	408					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TTGACAACGAGAGGGCAGTTG	0.537			NA											19	22					1.67942e-08	1.97446e-08	0.006122	1	0
NPHS2	7827	broad.mit.edu	37	1	179520525	179520525	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:179520525A>G	uc001gmq.3	-	8	1020	c.935T>C	c.(934-936)CTG>CCG	p.L312P	C1orf125_uc009wxg.2_Intron|C1orf125_uc001gmo.2_Intron|C1orf125_uc001gmp.2_Intron|C1orf125_uc009wxh.2_Intron|NPHS2_uc009wxi.2_Missense_Mutation_p.L244P|C1orf125_uc001gmr.2_RNA	NM_014625	NP_055440	Q9NP85	PODO_HUMAN	podocin	312	Cytoplasmic (Potential).				excretion	integral to plasma membrane	protein binding				0						GGTGCCTGACAGAATCTCAGC	0.498			NA											29	32					0	0	0.00632	0	0
CEP350	9857	broad.mit.edu	37	1	180034295	180034295	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:180034295C>T	uc001gnt.2	+	27	5838	c.5455C>T	c.(5455-5457)CCT>TCT	p.P1819S	CEP350_uc009wxl.2_Missense_Mutation_p.P1818S	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1819						centrosome|nucleus|spindle				ovary(4)	4						GGCAACCAGTCCTGGTCCAAC	0.428			NA											5	17					0	0	0.000602	0	0
CACNA1E	777	broad.mit.edu	37	1	181700366	181700366	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:181700366C>G	uc001gow.2	+	19	2461	c.2296C>G	c.(2296-2298)CTG>GTG	p.L766V	CACNA1E_uc009wxs.2_Intron|CACNA1E_uc001gox.1_5'Flank|CACNA1E_uc009wxt.2_5'Flank	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	766	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CAGCAGCCACCTGTATGTGTG	0.522			NA											9	10					0	0	0.001368	0	0
CACNA1E	777	broad.mit.edu	37	1	181702613	181702613	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:181702613G>T	uc001gow.2	+	21	3154	c.2989G>T	c.(2989-2991)GGA>TGA	p.G997*	CACNA1E_uc009wxs.2_Nonsense_Mutation_p.G885*|CACNA1E_uc001gox.1_Nonsense_Mutation_p.G223*|CACNA1E_uc009wxt.2_Nonsense_Mutation_p.G223*	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	997	Cytoplasmic (Potential).				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						CGGGCTGGCAGGAGGCCTTGA	0.617			NA											8	27					0.000157383	0.000167241	0.00308	1	0
ZNF648	127665	broad.mit.edu	37	1	182026788	182026788	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:182026788T>C	uc001goz.2	-	2	566	c.358A>G	c.(358-360)AGC>GGC	p.S120G		NM_001009992	NP_001009992	Q5T619	ZN648_HUMAN	zinc finger protein 648	120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGAGCTCTGCTTGCTCCCGGG	0.557	NSCLC(71;908 1374 5429 20458 35642)		NA											37	42					0	0	0.004878	0	0
HMCN1	83872	broad.mit.edu	37	1	185815179	185815179	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:185815179C>A	uc001grq.1	+	2	519	c.290C>A	c.(289-291)ACC>AAC	p.T97N		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	97	VWFA.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GTGACAATTACCACAGATCCC	0.363			NA											21	16					1.50039e-11	1.88181e-11	0.001882	1	0
HMCN1	83872	broad.mit.edu	37	1	185939626	185939626	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:185939626G>T	uc001grq.1	+	15	2600	c.2371_splice	c.e15+1	p.S791_splice	HMCN1_uc001grr.1_Splice_Site_p.S132_splice	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor						response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GATGTTGGCTGTAAGCCTCCA	0.368			NA											91	59					1.13884e-41	2.02438e-41	0.00361	1	0
HMCN1	83872	broad.mit.edu	37	1	186088942	186088942	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:186088942C>G	uc001grq.1	+	79	12251	c.12022C>G	c.(12022-12024)CCA>GCA	p.P4008A		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4008	Ig-like C2-type 39.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TATTTTATTACCATGTGAAGC	0.383			NA											15	44					0	0	0.00245	0	0
HMCN1	83872	broad.mit.edu	37	1	186143709	186143709	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:186143709G>T	uc001grq.1	+	103	16107	c.15878G>T	c.(15877-15879)AGA>ATA	p.R5293I	HMCN1_uc001grs.1_Missense_Mutation_p.R862I	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5293	EGF-like 5; calcium-binding (Potential).				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAGAATACAAGAGGCAGCTAT	0.418			NA											34	23					5.8336e-16	7.97892e-16	0.003271	1	0
PLA2G4A	5321	broad.mit.edu	37	1	186901983	186901983	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:186901983G>T	uc001gsc.2	+	8	852	c.647G>T	c.(646-648)GGA>GTA	p.G216V	PLA2G4A_uc010pos.1_Missense_Mutation_p.G156V	NM_024420	NP_077734	P47712	PA24A_HUMAN	cytosolic phospholipase A2, group IVA	216	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			lung(2)|breast(1)	3					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TACGAATCAGGAATTCTGGAT	0.408			NA											32	119					3.90053e-15	5.24956e-15	0.002445	1	0
FAM5C	339479	broad.mit.edu	37	1	190068145	190068145	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:190068145C>A	uc001gse.1	-	8	1536	c.1304G>T	c.(1303-1305)TGC>TTC	p.C435F	FAM5C_uc010pot.1_Missense_Mutation_p.C333F	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	435						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					GAACGCGGTGCAGACCACCTG	0.602			NA											27	28					3.28513e-13	4.2328e-13	0.003954	1	0
FAM5C	339479	broad.mit.edu	37	1	190129960	190129960	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:190129960A>G	uc001gse.1	-	7	1254	c.1022T>C	c.(1021-1023)ATA>ACA	p.I341T	FAM5C_uc010pot.1_Missense_Mutation_p.I239T	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	341						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					CAAATGCATTATAGTAGATGT	0.323			NA											14	93					0	0	0.006122	0	0
RGS21	431704	broad.mit.edu	37	1	192335248	192335248	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:192335248T>G	uc001gsh.2	+	5	627	c.453T>G	c.(451-453)TTT>TTG	p.F151L		NM_001039152	NP_001034241	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	151					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(1)|skin(1)	2						GGCTCCCTTTTTTGTGAGGAA	0.328			NA											27	20					0	0	0.003954	0	0
KCNT2	343450	broad.mit.edu	37	1	196311306	196311306	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:196311306C>A	uc001gtd.1	-	15	1516	c.1456G>T	c.(1456-1458)GGG>TGG	p.G486W	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Missense_Mutation_p.G486W|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Missense_Mutation_p.G486W|KCNT2_uc001gth.1_Missense_Mutation_p.G7W	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	486	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ACTTCATTCCCGGAGCATCTA	0.343			NA											19	37					9.7654e-05	0.000104575	0.007413	1	0
CFHR2	3080	broad.mit.edu	37	1	196928191	196928191	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:196928191C>A	uc001gtq.1	+	5	871	c.794C>A	c.(793-795)CCC>CAC	p.P265H	CFHR2_uc001gtr.1_Missense_Mutation_p.P141H	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	265	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						CTGGTATATCCCAGTTGTGAA	0.303			NA											7	31					0.00307968	0.00318168	0.00308	1	0
ASPM	259266	broad.mit.edu	37	1	197073924	197073924	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:197073924T>C	uc001gtu.2	-	18	4714	c.4457A>G	c.(4456-4458)TAT>TGT	p.Y1486C	ASPM_uc001gtv.2_Intron|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1486					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						AGATCTAATATAAATATATTT	0.294			NA											30	15					0	0	0.008361	0	0
ASPM	259266	broad.mit.edu	37	1	197091635	197091635	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:197091635T>A	uc001gtu.2	-	14	3738	c.3481A>T	c.(3481-3483)ATA>TTA	p.I1161L	ASPM_uc001gtv.2_Missense_Mutation_p.I1161L|ASPM_uc001gtw.3_Intron	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	1161	CH 2.				mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						CGCTGACATATAGCGTCAAAT	0.413			NA											11	13					0	0	0.008291	0	0
CACNA1S	779	broad.mit.edu	37	1	201013584	201013584	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:201013584C>A	uc001gvv.2	-	39	4896	c.4669G>T	c.(4669-4671)GCA>TCA	p.A1557S		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	1557	Cytoplasmic (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CGCAGCCCTGCCTGGGGATGA	0.493			NA											29	37					3.1745e-13	4.09571e-13	0.008361	1	0
MYOG	4656	broad.mit.edu	37	1	203055013	203055013	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:203055013T>A	uc001gzd.2	-	1	365	c.77A>T	c.(76-78)CAC>CTC	p.H26L		NM_002479	NP_002470	P15173	MYOG_HUMAN	myogenin	26					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity			skin(2)	2						GCCCTGGAGGTGGACAGGCAG	0.627			NA											27	48					0	0	0.004656	0	0
ADORA1	134	broad.mit.edu	37	1	203134963	203134963	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:203134963C>A	uc001gze.1	+	4	1349	c.916C>A	c.(916-918)CAT>AAT	p.H306N	FMOD_uc010pqi.1_Intron|ADORA1_uc001gzf.1_Missense_Mutation_p.H306N|ADORA1_uc010pqg.1_Missense_Mutation_p.H238N|ADORA1_uc009xak.1_3'UTR|ADORA1_uc010pqh.1_Missense_Mutation_p.H339N	NM_000674	NP_000665	P30542	AA1R_HUMAN	adenosine A1 receptor	306	Cytoplasmic (Potential).				induction of apoptosis by extracellular signals|inflammatory response|nervous system development|phagocytosis	integral to plasma membrane				large_intestine(1)	1					Aminophylline(DB01223)|Caffeine(DB00201)|Defibrotide(DB04932)|Gabapentin(DB00996)|Imipramine(DB00458)|Pegademase bovine(DB00061)|Theophylline(DB00277)	TTGGAATGACCATTTCCGCTG	0.572			NA											21	61					2.89027e-11	3.60864e-11	0.002299	1	0
PRELP	5549	broad.mit.edu	37	1	203452734	203452734	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:203452734T>C	uc001gzs.2	+	2	622	c.422T>C	c.(421-423)ATA>ACA	p.I141T	PRELP_uc001gzt.2_Missense_Mutation_p.I141T	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	141	LRR 3.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			ATCCGCAAGATAGACCAGAGG	0.567			NA											38	76					0	0	0.00623	0	0
REN	5972	broad.mit.edu	37	1	204128682	204128682	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:204128682C>G	uc001haq.2	-	5	578	c.534G>C	c.(532-534)ACG>ACC	p.T178T		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	178					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CGGGCATCTCCGTGACCTCTC	0.577			NA											15	34					0	0	0.004007	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204402453	204402453	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:204402453T>C	uc001haw.2	-	27	4423	c.3944A>G	c.(3943-3945)TAC>TGC	p.Y1315C	PIK3C2B_uc010pqv.1_Missense_Mutation_p.Y1287C	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1315	PI3K/PI4K.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			CCTAGTGAAGTAGGTAGTGGC	0.537			NA											34	23					0	0	0.002836	0	0
CD34	947	broad.mit.edu	37	1	208084384	208084384	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:208084384C>T	uc001hgw.1	-	1	300	c.42G>A	c.(40-42)CCG>CCA	p.P14P	CD34_uc001hgx.1_Silent_p.P14P|CD34_uc010psj.1_5'UTR	NM_001025109	NP_001020280	P28906	CD34_HUMAN	CD34 antigen isoform a	14					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			ovary(1)	1						TCCAGCCCCGCGGCATCCTGG	0.607			NA											7	18					0	0	0.00308	0	0
LOC642587	642587	broad.mit.edu	37	1	209605662	209605662	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:209605662G>A	uc009xcn.2	+	4	660	c.277G>A	c.(277-279)GCA>ACA	p.A93T		NM_001104548	NP_001098018			hypothetical protein LOC642587												0				OV - Ovarian serous cystadenocarcinoma(81;0.0422)		agcagcagcagcagcagcagc	0.279			NA											3	12					0	0	0.004672	0	0
LAMB3	3914	broad.mit.edu	37	1	209803114	209803114	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:209803114C>T	uc001hhg.2	-	9	1490	c.1100G>A	c.(1099-1101)CGC>CAC	p.R367H	LAMB3_uc009xco.2_Missense_Mutation_p.R367H|LAMB3_uc001hhh.2_Missense_Mutation_p.R367H|LAMB3_uc010psl.1_RNA	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	367	Laminin EGF-like 2.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGCTCCCGGGCGCCGGTTCCG	0.572			NA											15	61					0	0	0.00245	0	0
HSD11B1	3290	broad.mit.edu	37	1	209879219	209879219	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:209879219C>G	uc001hhj.2	+	3	259	c.152C>G	c.(151-153)GCT>GGT	p.A51G	HSD11B1_uc001hhk.2_Missense_Mutation_p.A51G	NM_181755	NP_861420	P28845	DHI1_HUMAN	11-beta-hydroxysteroid dehydrogenase 1	51	Lumenal (Potential).|NADP.				glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase (NADP+) activity|11-beta-hydroxysteroid dehydrogenase|binding			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	AGAGAGATGGCTTATCATCTG	0.512			NA											55	40					0	0	0.00361	0	0
KCNH1	3756	broad.mit.edu	37	1	211280628	211280628	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:211280628C>A	uc001hib.2	-	2	341	c.171G>T	c.(169-171)AGG>AGT	p.R57S	KCNH1_uc001hic.2_Missense_Mutation_p.R57S	NM_172362	NP_758872	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H,	57	Cytoplasmic (Potential).|PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			ovary(4)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		TCACTTCTGCCCTGTGATAGC	0.388			NA											33	78					4.2108e-06	4.6562e-06	0.009535	1	0
TRAF5	7188	broad.mit.edu	37	1	211526639	211526639	+	Missense_Mutation	SNP	G	G	T	rs148579195	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:211526639G>T	uc001hih.2	+	2	118	c.58G>T	c.(58-60)GGC>TGC	p.G20C	TRAF5_uc001hii.2_Missense_Mutation_p.G20C|TRAF5_uc010psx.1_Missense_Mutation_p.G20C|TRAF5_uc010psy.1_Missense_Mutation_p.G20C|TRAF5_uc001hij.2_Missense_Mutation_p.G20C	NM_004619	NP_004610	O00463	TRAF5_HUMAN	TNF receptor-associated factor 5	20					apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis	CD40 receptor complex|centrosome|internal side of plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(2)|ovary(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00946)|all cancers(67;0.0808)|Epithelial(68;0.144)		CCAGAATTCCGGCAACTCCAT	0.493			NA									OREG0014232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	78	87					1.92282e-43	3.44009e-43	0.00361	1	0
KCNK2	3776	broad.mit.edu	37	1	215408333	215408333	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:215408333G>C	uc001hkq.2	+	7	1295	c.1126G>C	c.(1126-1128)GAG>CAG	p.E376Q	KCNK2_uc001hko.2_Missense_Mutation_p.E372Q|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.E361Q	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	376	Cytoplasmic (Potential).|Required for basal channel activity (By similarity).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CCACAATCAGGAGCTGACTCC	0.537			NA											13	7					0	0	0.001368	0	0
USH2A	7399	broad.mit.edu	37	1	216219883	216219883	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:216219883A>T	uc001hku.1	-	32	6602	c.6215T>A	c.(6214-6216)CTG>CAG	p.L2072Q		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	2072	Extracellular (Potential).|Fibronectin type-III 7.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCAGGAGAGCAGCAAAGAACT	0.423			NA								HNSCC(13;0.011)			38	3					0	0	0.009718	0	0
USH2A	7399	broad.mit.edu	37	1	216405386	216405386	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:216405386C>A	uc001hku.1	-	14	3289	c.2902G>T	c.(2902-2904)GGT>TGT	p.G968C	USH2A_uc001hkv.2_Missense_Mutation_p.G968C	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	968	Extracellular (Potential).|Laminin EGF-like 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACACACTGACCAGTCAGGCTA	0.448			NA								HNSCC(13;0.011)			61	11					3.89483e-19	5.66361e-19	0.00361	1	0
SLC30A10	55532	broad.mit.edu	37	1	220101623	220101623	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:220101623C>G	uc001hlw.2	-	1	371	c.160G>C	c.(160-162)GGC>CGC	p.G54R	SLC30A10_uc001hlu.1_Intron|SLC30A10_uc001hlx.2_5'UTR	NM_018713	NP_061183	Q6XR72	ZNT10_HUMAN	solute carrier family 30 (zinc transporter),	54	Helical; (Potential).				zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity				0				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		GCGCTCAGGCCCACGCACAGC	0.697	Colon(76;360 1614 43677 51136)		NA											11	2					0	0	0.008291	0	0
OBSCN	84033	broad.mit.edu	37	1	228434381	228434381	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:228434381G>T	uc009xez.1	+	13	3954	c.3910G>T	c.(3910-3912)GTG>TTG	p.V1304L	OBSCN_uc001hsn.2_Missense_Mutation_p.V1304L	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	1304	Ig-like 13.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				CAGTTCGAAAGTGCGCATAGA	0.647			NA											69	19					1.55545e-33	2.65745e-33	0.00361	1	0
OBSCN	84033	broad.mit.edu	37	1	228479742	228479742	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:228479742A>G	uc009xez.1	+	39	10527	c.10483A>G	c.(10483-10485)ATC>GTC	p.I3495V	OBSCN_uc001hsn.2_Missense_Mutation_p.I3495V|OBSCN_uc001hsq.1_Missense_Mutation_p.I751V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	3495	Ig-like 35.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				GGACAGATACATCCTGAGGCA	0.632			NA											71	12					0	0	0.00361	0	0
NUP133	55746	broad.mit.edu	37	1	229622275	229622276	+	Splice_Site	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:229622275_229622276CC>AA	uc001htn.2	-	11	1435	c.1343_splice	c.e11-1	p.G448_splice		NM_018230	NP_060700	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa						carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			breast(4)|skin(2)|ovary(1)	7	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				AACACTATCTCCTAAAAGAAAG	0.351			NA											19	5					0	0	0.004672	0	0
RBM34	23029	broad.mit.edu	37	1	235324532	235324532	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:235324532C>T	uc001hwn.2	-	1	40	c.10G>A	c.(10-12)GAA>AAA	p.E4K	RBM34_uc001hwo.2_RNA|ARID4B_uc001hwp.2_RNA|RBM34_uc010pxp.1_Missense_Mutation_p.E4K	NM_015014	NP_055829	P42696	RBM34_HUMAN	RNA binding motif protein 34 isoform 1	4						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			CTCATCCCTTCCAAGGCCATT	0.627			NA											90	16					0	0	0.00361	0	0
NID1	4811	broad.mit.edu	37	1	236201413	236201413	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:236201413C>A	uc001hxo.2	-	5	1378	c.1276G>T	c.(1276-1278)GTT>TTT	p.V426F	NID1_uc009xgd.2_Missense_Mutation_p.V426F	NM_002508	NP_002499	P14543	NID1_HUMAN	nidogen 1 precursor	426	EGF-like 1.				cell-matrix adhesion	basement membrane	calcium ion binding			large_intestine(1)|pancreas(1)	2	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CCTTCTGCAACACATTGCCTG	0.522			NA											51	19					7.34454e-26	1.17683e-25	0.00361	1	0
RYR2	6262	broad.mit.edu	37	1	237965165	237965165	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:237965165C>A	uc001hyl.1	+	98	14220	c.14100C>A	c.(14098-14100)TCC>TCA	p.S4700S	RYR2_uc010pyb.1_Silent_p.S133S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	4700					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GACTGAACTCCATTGATGTGA	0.393			NA											22	3					6.21321e-17	8.63244e-17	0.00278	1	0
FMN2	56776	broad.mit.edu	37	1	240255968	240255968	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:240255968C>T	uc010pyd.1	+	1	784	c.559C>T	c.(559-561)CAT>TAT	p.H187Y	FMN2_uc010pye.1_Missense_Mutation_p.H187Y	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	187					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTATAGCTTCCATTCGGCTAC	0.478			NA											43	12					0	0	0.00361	0	0
RGS7	6000	broad.mit.edu	37	1	240975230	240975230	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:240975230G>T	uc001hyv.2	-	14	1400	c.1070C>A	c.(1069-1071)TCG>TAG	p.S357*	RGS7_uc010pyh.1_Nonsense_Mutation_p.S331*|RGS7_uc010pyj.1_Nonsense_Mutation_p.S273*|RGS7_uc001hyu.2_Nonsense_Mutation_p.S357*|RGS7_uc009xgn.1_Nonsense_Mutation_p.S304*|RGS7_uc001hyw.2_Nonsense_Mutation_p.S357*|RGS7_uc001hyt.2_Nonsense_Mutation_p.S189*	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	357	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TAAATTTTCCGAGCTGAATTC	0.398			NA											33	9					2.42023e-17	3.39676e-17	0.003271	1	0
WDR64	128025	broad.mit.edu	37	1	241943305	241943305	+	Splice_Site	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:241943305G>C	uc001hzf.1	+	11	1319	c.1166_splice	c.e11-1	p.E389_splice	WDR64_uc001hzg.1_Splice_Site_p.E302_splice	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64											skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			ATTTTATACAGAAGGACATGT	0.259			NA											8	2					0	0	0.008291	0	0
CEP170	9859	broad.mit.edu	37	1	243349110	243349110	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:243349110C>A	uc001hzs.2	-	10	1945	c.1537G>T	c.(1537-1539)GAA>TAA	p.E513*	CEP170_uc001hzt.2_Intron|CEP170_uc001hzu.2_Intron	NM_014812	NP_055627	Q5SW79	CE170_HUMAN	centrosomal protein 170kDa isoform alpha	513						centriole|microtubule|spindle				ovary(1)|haematopoietic_and_lymphoid_tissue(1)	2	all_neural(11;0.101)	all_cancers(173;0.003)	all cancers(7;5.81e-06)|GBM - Glioblastoma multiforme(7;0.000443)|OV - Ovarian serous cystadenocarcinoma(106;0.0101)			GCTTCCACTTCCTCACTGTTG	0.353			NA											72	22					1.17611e-34	2.02547e-34	0.00361	1	0
VN1R5	317705	broad.mit.edu	37	1	247419950	247419950	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:247419950C>A	uc010pyu.1	+	2	577	c.577C>A	c.(577-579)CGG>AGG	p.R193R		NM_173858	NP_776257	Q7Z5H4	VN1R5_HUMAN	vomeronasal 1 receptor 5	193	Cytoplasmic (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0	all_cancers(71;5.7e-05)|all_epithelial(71;1.03e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)	all_cancers(173;0.0314)	OV - Ovarian serous cystadenocarcinoma(106;0.00854)			CCCAGTGAAACGGGGCCAGTC	0.463	GBM(98;63 1399 4825 21305 33017)		NA											172	41					2.41315e-71	4.51357e-71	0.00361	1	0
ZNF496	84838	broad.mit.edu	37	1	247464180	247464180	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:247464180C>T	uc001ico.2	-	9	1870	c.1405G>A	c.(1405-1407)GGG>AGG	p.G469R	ZNF496_uc009xgv.2_Missense_Mutation_p.G505R|ZNF496_uc001icp.2_Missense_Mutation_p.G469R	NM_032752	NP_116141	Q96IT1	ZN496_HUMAN	zinc finger protein 496	469	C2H2-type 3.				positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			AAGCTCTTCCCGCAGGCACCA	0.657			NA											40	4					0	0	0.007835	0	0
OR2T3	343173	broad.mit.edu	37	1	248636956	248636956	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:248636956G>T	uc001iel.1	+	1	305	c.305G>T	c.(304-306)TGT>TTT	p.C102F		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	102	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCGTCAGGCTGTGGGATCCAG	0.557			NA											37	8					1.48734e-19	2.17259e-19	0.003214	1	0
OR2T3	343173	broad.mit.edu	37	1	248637363	248637363	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:248637363G>T	uc001iel.1	+	1	712	c.712G>T	c.(712-714)GGC>TGC	p.G238C		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	238	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTCTGCCGCCGGCCACAGGAA	0.562			NA											156	39					4.10442e-84	7.73679e-84	0.00361	1	0
PITRM1	10531	broad.mit.edu	37	10	3206021	3206021	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:3206021G>A	uc010qah.1	-	6	623	c.591C>T	c.(589-591)CAC>CAT	p.H197H	PITRM1_uc001igr.1_Silent_p.H229H|PITRM1_uc001igt.1_Silent_p.H229H|PITRM1_uc001igu.1_Silent_p.H221H|PITRM1_uc010qai.1_Silent_p.H200H|PITRM1_uc001igw.1_Silent_p.H229H|uc001igx.1_5'Flank			E7ES23	E7ES23_HUMAN	SubName: Full=cDNA FLJ54065, moderately similar to Mus musculus pitrilysin metallepetidase 1 (Pitrm1), mRNA;	197					proteolysis		metalloendopeptidase activity|zinc ion binding			pancreas(1)	1						CTGAGTACGTGTGGTCAGGAA	0.448			NA											40	13					0	0	0.004878	0	0
IL2RA	3559	broad.mit.edu	37	10	6104107	6104107	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:6104107G>C	uc001iiz.1	-	1	167	c.8C>G	c.(7-9)TCA>TGA	p.S3*	IL2RA_uc009xih.1_Nonsense_Mutation_p.S3*	NM_000417	NP_000408	P01589	IL2RA_HUMAN	interleukin 2 receptor, alpha chain precursor	3					cell proliferation	integral to membrane	interleukin-2 receptor activity			ovary(1)|skin(1)	2					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	CAGCAGGTATGAATCCATCTT	0.612			NA											13	47					0	0	0.004007	0	0
ITIH5	80760	broad.mit.edu	37	10	7608211	7608211	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:7608211C>A	uc001ijq.2	-	13	2388	c.2309G>T	c.(2308-2310)AGA>ATA	p.R770I	ITIH5_uc001ijp.2_Missense_Mutation_p.R556I	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	770					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GAGCACCAGTCTGTCCCCACC	0.582			NA											17	2					0.00400662	0.00413491	0.004007	1	0
ITIH5	80760	broad.mit.edu	37	10	7611676	7611676	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:7611676G>T	uc001ijq.2	-	12	2183	c.2104C>A	c.(2104-2106)CAG>AAG	p.Q702K	ITIH5_uc001ijp.2_Missense_Mutation_p.Q488K	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	702					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TCCCCGGGCTGCCCATCAATG	0.547			NA											25	4					4.26978e-12	5.40075e-12	0.00333	1	0
ITIH5	80760	broad.mit.edu	37	10	7679202	7679202	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:7679202C>A	uc001ijq.2	-	5	720	c.641G>T	c.(640-642)GGG>GTG	p.G214V	ITIH5_uc001ijr.1_Missense_Mutation_p.G214V	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	214					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						TTCCCCGCGCCCACTGCCCCT	0.622			NA											88	25					5.88579e-26	9.43874e-26	0.00361	1	0
UCMA	221044	broad.mit.edu	37	10	13264168	13264168	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:13264168G>T	uc001imd.2	-	5	425	c.352C>A	c.(352-354)CAG>AAG	p.Q118K		NM_145314	NP_660357	Q8WVF2	UCMA_HUMAN	upper zone of growth plate and cartilage matrix	118	Potential.					proteinaceous extracellular matrix					0						TGGCGCCACTGCTCCACAGCC	0.607			NA											91	11					3.61922e-38	6.32873e-38	0.00361	1	0
FAM171A1	221061	broad.mit.edu	37	10	15296861	15296861	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:15296861G>T	uc001iob.2	-	4	443	c.436C>A	c.(436-438)CGC>AGC	p.R146S		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	146	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						AAATGAACGCGAGGCTGTGGC	0.552			NA											16	3					1.45105e-14	1.9182e-14	0.006122	1	0
ITGA8	8516	broad.mit.edu	37	10	15658514	15658514	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:15658514T>A	uc001ioc.1	-	14	1444	c.1444A>T	c.(1444-1446)AGA>TGA	p.R482*	ITGA8_uc010qcb.1_Nonsense_Mutation_p.R467*	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	482	Extracellular (Potential).|FG-GAP 7.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						ACCACATACCTGTAAACAGCG	0.343			NA											33	1					0	0	0.003271	0	0
PLXDC2	84898	broad.mit.edu	37	10	20335798	20335798	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:20335798G>C	uc001iqg.1	+	3	962	c.325G>C	c.(325-327)GAG>CAG	p.E109Q	PLXDC2_uc001iqh.1_Intron	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	109	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						ATTATTGCAGGAGGATACAGA	0.313			NA											86	10					0	0	0.00361	0	0
MLLT10	8028	broad.mit.edu	37	10	21903816	21903816	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:21903816A>G	uc001iqs.2	+	7	914	c.566A>G	c.(565-567)CAA>CGA	p.Q189R	MLLT10_uc001iqt.2_Missense_Mutation_p.Q189R|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.Q189R|MLLT10_uc001ira.2_5'Flank|MLLT10_uc001iqz.2_5'UTR	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	189	Interaction with FSTL3.|Self-association.|PHD-type 2.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						GATAATGTCCAATACTGTGGC	0.338			NA	T	MLL|PICALM|CDK6	AL								4	52					0	0	0.000602	0	0
GAD2	2572	broad.mit.edu	37	10	26507994	26507994	+	Silent	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:26507994A>C	uc001isp.2	+	4	812	c.309A>C	c.(307-309)GGA>GGC	p.G103G	GAD2_uc009xkr.2_Silent_p.G103G|GAD2_uc001isq.2_Silent_p.G103G	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	103					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CGTGTGATGGAGAAAGGCCCA	0.363			NA											47	30					0	0	0.00361	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316682	30316682	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:30316682G>T	uc001iux.2	-	2	2454	c.2395C>A	c.(2395-2397)CGG>AGG	p.R799R	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.R661R|KIAA1462_uc009xle.1_Silent_p.R799R	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	799										ovary(4)	4						ACCACCTCCCGCTTAGGCCCA	0.612			NA											107	64					2.66069e-56	4.89607e-56	0.00361	1	0
FZD8	8325	broad.mit.edu	37	10	35929082	35929082	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:35929082C>A	uc001iyz.1	-	1	1281	c.1276G>T	c.(1276-1278)GGT>TGT	p.G426C		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	426	Cytoplasmic (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						CACTTCATACCGGCCGCCAGG	0.632			NA											9	43					1.12685e-05	1.23405e-05	0.004482	1	0
ZNF33A	7581	broad.mit.edu	37	10	38343357	38343357	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:38343357A>T	uc001izh.2	+	5	480	c.302A>T	c.(301-303)CAT>CTT	p.H101L	ZNF33A_uc001izg.2_Missense_Mutation_p.H102L|ZNF33A_uc010qev.1_Missense_Mutation_p.H108L|ZNF33A_uc001izi.1_Missense_Mutation_p.H102L	NM_006974	NP_008905	Q06730	ZN33A_HUMAN	zinc finger protein 33A isoform b	101						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(1)	3						CAATCTAAACATTTGTGGGAA	0.348			NA											68	29					0	0	0.00361	0	0
ZNF37A	7587	broad.mit.edu	37	10	38406450	38406450	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:38406450G>T	uc001izk.2	+	8	1190	c.371G>T	c.(370-372)GGG>GTG	p.G124V	ZNF37A_uc001izl.2_Missense_Mutation_p.G124V|ZNF37A_uc001izm.2_Missense_Mutation_p.G124V	NM_001007094	NP_001007095	P17032	ZN37A_HUMAN	zinc finger protein 37a	124						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)	1						AATAAAAATGGGAACAGCTTC	0.338			NA											72	41					1.43675e-24	2.26462e-24	0.00361	1	0
HNRNPA3P1	10151	broad.mit.edu	37	10	44285076	44285076	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:44285076C>G	uc010qfe.1	-	1	790	c.760G>C	c.(760-762)GGT>CGT	p.G254R		NR_002726				SubName: Full=cDNA FLJ52659, highly similar to Heterogeneous nuclear ribonucleoprotein A3; SubName: Full=cDNA, FLJ79333, highly similar to Heterogeneous nuclear ribonucleoprotein A3; SubName: Full=Heterogeneous nuclear ribonucleoprotein A3, isoform CRA_a;												0						ctgctgccaccacctccacca	0.065			NA											25	48					0	0	0.004656	0	0
RBP3	5949	broad.mit.edu	37	10	48382182	48382182	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:48382182T>C	uc001jez.2	-	4	3581	c.3467A>G	c.(3466-3468)TAT>TGT	p.Y1156C		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	1156	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTTCATGATATAGGTGAACTC	0.592			NA											17	50					0	0	0.002299	0	0
RBP3	5949	broad.mit.edu	37	10	48389347	48389347	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:48389347C>T	uc001jez.2	-	1	1645	c.1531G>A	c.(1531-1533)GAT>AAT	p.D511N		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	511	4 X approximate tandem repeats.|2.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	GTGCGGCGATCATAGGTGGTG	0.657			NA											29	28					0	0	0.007291	0	0
FRMPD2	143162	broad.mit.edu	37	10	49431294	49431294	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:49431294C>A	uc001jgi.2	-	11	1295	c.1188G>T	c.(1186-1188)CTG>CTT	p.L396L	FRMPD2_uc001jgh.2_Silent_p.L365L|FRMPD2_uc001jgj.2_Silent_p.L374L	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	396	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		TTTCACTGTCCAGGAAAAAGA	0.468			NA											33	32					9.65021e-13	1.23681e-12	0.002096	1	0
LRRC18	474354	broad.mit.edu	37	10	50121911	50121911	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:50121911C>T	uc001jhd.2	-	1	370	c.290G>A	c.(289-291)AGC>AAC	p.S97N	WDFY4_uc001jha.3_Intron|LRRC18_uc001jhe.1_Missense_Mutation_p.S97N	NM_001006939	NP_001006940	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	97	LRR 4.					cytoplasm				ovary(1)|pancreas(1)	2						GTAGAGCAGGCTGGTCATCTG	0.567			NA											20	20					0	0	0.008871	0	0
C10orf72	196740	broad.mit.edu	37	10	50272760	50272760	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:50272760C>A	uc001jhf.2	-	5	685	c.656G>T	c.(655-657)TGC>TTC	p.C219F		NM_001031746	NP_001026916	Q8IW00	CJ072_HUMAN	hypothetical protein LOC196740 isoform 1	219	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0						GTTCTGAGGGCATTTCACCAA	0.308			NA											23	34					2.21704e-12	2.82089e-12	0.00278	1	0
C10orf128	170371	broad.mit.edu	37	10	50374978	50374978	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:50374978C>G	uc001jhn.3	-	3	200	c.174G>C	c.(172-174)ATG>ATC	p.M58I	C10orf128_uc001jhl.3_RNA|C10orf128_uc001jhm.3_Missense_Mutation_p.M58I|C10orf128_uc010qgo.1_Missense_Mutation_p.M58I|C10orf128_uc001jho.3_Missense_Mutation_p.M58I	NM_001010863	NP_001010863	Q5T292	CJ128_HUMAN	hypothetical protein LOC170371 precursor	58	Helical; (Potential).					integral to membrane				lung(1)	1						GCCTCCTGATCATGCAGATCT	0.577			NA											16	43					0	0	0.004007	0	0
PGBD3	267004	broad.mit.edu	37	10	50723798	50723798	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:50723798C>A	uc001jht.2	-	2	1618	c.1363G>T	c.(1363-1365)GTG>TTG	p.V455L	ERCC6_uc001jhs.3_Intron|PGBD3_uc009xoe.2_Missense_Mutation_p.V923L|PGBD3_uc001jhu.2_Missense_Mutation_p.V923L	NM_170753	NP_736609	Q8N328	PGBD3_HUMAN	hypothetical protein LOC267004	455										pancreas(1)|breast(1)|skin(1)	3						TGGTTATACACTTTGATCATG	0.438			NA											100	54					1.85599e-38	3.25134e-38	0.00361	1	0
OGDHL	55753	broad.mit.edu	37	10	50964944	50964944	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:50964944A>T	uc001jie.2	-	3	395	c.253T>A	c.(253-255)TCT>ACT	p.S85T	OGDHL_uc009xog.2_Missense_Mutation_p.S112T|OGDHL_uc010qgt.1_Intron|OGDHL_uc010qgu.1_Intron|OGDHL_uc009xoh.2_5'UTR	NM_018245	NP_060715	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like isoform a	85					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			pancreas(1)	1						GGCTGAGCAGAGCCAGAAAAG	0.587			NA											28	30					0	0	0.00632	0	0
PCDH15	65217	broad.mit.edu	37	10	55566820	55566820	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:55566820C>G	uc010qhq.1	-	36	4963	c.4568G>C	c.(4567-4569)AGT>ACT	p.S1523T	PCDH15_uc010qhr.1_Missense_Mutation_p.S1518T	NM_001142771	NP_001136243	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD3-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TTCAGGAGCACTGTCTTCTCC	0.388			NA								HNSCC(58;0.16)			7	25					0	0	0.001984	0	0
PCDH15	65217	broad.mit.edu	37	10	55570367	55570367	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:55570367C>A	uc010qhs.1	-	36	4862	c.4467G>T	c.(4465-4467)GAG>GAT	p.E1489D	PCDH15_uc010qhq.1_Missense_Mutation_p.E1482D|PCDH15_uc010qhr.1_Missense_Mutation_p.E1477D|PCDH15_uc010qht.1_Missense_Mutation_p.E1482D|PCDH15_uc010qhu.1_Missense_Mutation_p.R1501M	NM_001142769	NP_001136241	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD2-1 precursor	Error:Variant_position_missing_in_Q96QU1_after_alignment					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CACCATATTCCTCCTGTCCAG	0.363			NA								HNSCC(58;0.16)			81	23					2.78983e-34	4.78328e-34	0.00361	1	0
PCDH15	65217	broad.mit.edu	37	10	55591103	55591103	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:55591103T>A	uc001jju.1	-	30	4569	c.4174A>T	c.(4174-4176)ATC>TTC	p.I1392F	PCDH15_uc010qhq.1_Missense_Mutation_p.I1397F|PCDH15_uc010qhr.1_Missense_Mutation_p.I1392F|PCDH15_uc010qhs.1_Missense_Mutation_p.I1404F|PCDH15_uc010qht.1_Missense_Mutation_p.I1399F|PCDH15_uc010qhu.1_Missense_Mutation_p.I1392F|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.I1392F|PCDH15_uc010qhw.1_Missense_Mutation_p.I1355F|PCDH15_uc010qhx.1_Missense_Mutation_p.I1321F|PCDH15_uc010qhy.1_Missense_Mutation_p.I1397F|PCDH15_uc010qhz.1_Missense_Mutation_p.I1392F|PCDH15_uc010qia.1_Missense_Mutation_p.I1370F|PCDH15_uc010qib.1_Missense_Mutation_p.I1370F	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1392	Helical; (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACCACCAAGATGGCAGGAATG	0.463			NA								HNSCC(58;0.16)			37	8					0	0	0.007835	0	0
PCDH15	65217	broad.mit.edu	37	10	55912946	55912946	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:55912946G>T	uc001jju.1	-	14	2093	c.1698C>A	c.(1696-1698)ACC>ACA	p.T566T	PCDH15_uc010qhq.1_Silent_p.T571T|PCDH15_uc010qhr.1_Silent_p.T566T|PCDH15_uc010qhs.1_Silent_p.T578T|PCDH15_uc010qht.1_Silent_p.T573T|PCDH15_uc010qhu.1_Silent_p.T566T|PCDH15_uc001jjv.1_Silent_p.T544T|PCDH15_uc010qhv.1_Silent_p.T566T|PCDH15_uc010qhw.1_Silent_p.T529T|PCDH15_uc010qhx.1_Silent_p.T566T|PCDH15_uc010qhy.1_Silent_p.T571T|PCDH15_uc010qhz.1_Silent_p.T566T|PCDH15_uc010qia.1_Silent_p.T544T|PCDH15_uc010qib.1_Silent_p.T544T|PCDH15_uc001jjw.2_Silent_p.T566T	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	566	Cadherin 5.|Extracellular (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGGAGCGATGGTGATAAGCC	0.498			NA								HNSCC(58;0.16)			42	9					4.67007e-22	7.12858e-22	0.00874	1	0
NEUROG3	50674	broad.mit.edu	37	10	71332416	71332416	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:71332416G>T	uc001jpp.2	-	2	542	c.384C>A	c.(382-384)GCC>GCA	p.A128A		NM_020999	NP_066279	Q9Y4Z2	NGN3_HUMAN	neurogenin 3	128	Helix-loop-helix motif.				central nervous system development|endocrine pancreas development|peripheral nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	transcription coactivator activity				0						TGTAGTTGTGGGCGAAGCGCA	0.662			NA											29	3					1.39806e-14	1.85576e-14	0.008361	1	0
ADAMTS14	140766	broad.mit.edu	37	10	72520564	72520564	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:72520564G>C	uc001jrh.2	+	22	3627	c.3627G>C	c.(3625-3627)CTG>CTC	p.L1209L	ADAMTS14_uc001jrg.2_Silent_p.L1212L	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1209	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						GAGAAGACCTGAGACATCCCG	0.642			NA											25	8					0	0	0.005443	0	0
UNC5B	219699	broad.mit.edu	37	10	73050686	73050686	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:73050686G>T	uc001jro.2	+	9	1559	c.1114G>T	c.(1114-1116)GGG>TGG	p.G372W	UNC5B_uc001jrp.2_Missense_Mutation_p.G361W	NM_170744	NP_734465	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B precursor	372	Extracellular (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				ovary(2)|lung(1)	3						GGAGGCCTCAGGGGATGCGGC	0.637			NA											131	38					1.5108e-63	2.80951e-63	0.00361	1	0
SPOCK2	9806	broad.mit.edu	37	10	73826741	73826741	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:73826741G>A	uc001jso.1	-	8	1292	c.847C>T	c.(847-849)CGT>TGT	p.R283C	SPOCK2_uc001jsp.2_Missense_Mutation_p.R283C	NM_014767	NP_055582	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	283					extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding				0						AAGAAGGGACGGATGCAGACC	0.587			NA											28	44					0	0	0.005443	0	0
KCNMA1	3778	broad.mit.edu	37	10	78832898	78832898	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:78832898G>T	uc001jxn.2	-	14	1883	c.1706C>A	c.(1705-1707)TCC>TAC	p.S569Y	KCNMA1_uc001jxj.2_Missense_Mutation_p.S569Y|KCNMA1_uc001jxk.1_Missense_Mutation_p.S184Y|KCNMA1_uc009xrt.1_Missense_Mutation_p.S389Y|KCNMA1_uc001jxl.1_Missense_Mutation_p.S223Y|KCNMA1_uc001jxo.2_Missense_Mutation_p.S569Y|KCNMA1_uc001jxm.2_Missense_Mutation_p.S569Y|KCNMA1_uc001jxq.2_Missense_Mutation_p.S569Y	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	569	Segment S7.|Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	AAGCATGGTGGAGAGGCCTTG	0.507			NA											24	5					7.87624e-14	1.02854e-13	0.00278	1	0
ZMIZ1	57178	broad.mit.edu	37	10	80976007	80976007	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:80976007G>A	uc001kaf.2	+	7	828	c.256G>A	c.(256-258)GAC>AAC	p.D86N	ZMIZ1_uc001kae.2_Missense_Mutation_p.D86N	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	86					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			TGCAAACCGAGACAAGTTCAC	0.597			NA											16	4					0	0	0.00499	0	0
GRID1	2894	broad.mit.edu	37	10	87379728	87379728	+	Silent	SNP	C	C	T	rs142646668	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:87379728C>T	uc001kdl.1	-	14	2357	c.2256G>A	c.(2254-2256)ACG>ACA	p.T752T	GRID1_uc009xsu.1_Intron|GRID1_uc010qmf.1_Silent_p.T323T	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	752	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	AGTCGTCATCCGTCAGGGCTG	0.567			NA								Multiple Myeloma(13;0.14)			41	7					0	0	0.002522	0	0
PTEN	5728	broad.mit.edu	37	10	89653808	89653808	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:89653808G>T	uc001kfb.2	+	3	1137	c.106G>T	c.(106-108)GGA>TGA	p.G36*		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	36	Phosphatase tensin-type.		G -> R (in endometrial hyperplasia).|G -> E (in glioma).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.?(4)|p.G36E(4)|p.Y27fs*1(2)|p.Y27_N212>Y(2)|p.G36V(2)|p.G36*(1)|p.A34_G36del(1)|p.G36R(1)|p.G36fs*18(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TATTGCTATGGGATTTCCTGC	0.284			31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			24	6					2.79863e-10	3.4235e-10	0.004656	1	0
LIPF	8513	broad.mit.edu	37	10	90429683	90429683	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:90429683A>T	uc001kfg.1	+	5	678	c.512A>T	c.(511-513)CAT>CTT	p.H171L	LIPF_uc001kfh.1_Missense_Mutation_p.H148L|LIPF_uc010qmt.1_Missense_Mutation_p.H181L|LIPF_uc010qmu.1_Missense_Mutation_p.H138L	NM_004190	NP_004181	P07098	LIPG_HUMAN	lipase, gastric precursor	171					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity				0		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TATGTTGGCCATTCCCAGGGC	0.403			NA											130	33					0	0	0.00361	0	0
TLL2	7093	broad.mit.edu	37	10	98157013	98157013	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:98157013G>A	uc001kml.1	-	11	1540	c.1314C>T	c.(1312-1314)GAC>GAT	p.D438D	TLL2_uc009xvf.1_Silent_p.D416D	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	438	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		AGAGCCGGCTGTCCGTGGAGA	0.577			NA											26	8					0	0	0.00333	0	0
TLL2	7093	broad.mit.edu	37	10	98170154	98170154	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:98170154G>T	uc001kml.1	-	9	1352	c.1126C>A	c.(1126-1128)CAC>AAC	p.H376N	TLL2_uc009xvf.1_Missense_Mutation_p.H354N	NM_012465	NP_036597	Q9Y6L7	TLL2_HUMAN	tolloid-like 2 precursor	376	CUB 1.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CAGACGCAGTGGGAGTAAGAT	0.567			NA											22	8					1.10923e-09	1.33494e-09	0.00278	1	0
PIK3AP1	118788	broad.mit.edu	37	10	98411116	98411116	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:98411116T>C	uc001kmq.2	-	6	1005	c.877A>G	c.(877-879)AAC>GAC	p.N293D	PIK3AP1_uc001kmp.2_Missense_Mutation_p.N115D	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	293	DBB.					cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GTCTCTGTGTTGTAGGGCACA	0.448			NA											15	22					0	0	0.003163	0	0
C10orf12	26148	broad.mit.edu	37	10	98741316	98741316	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:98741316G>T	uc001kmv.2	+	1	276	c.169G>T	c.(169-171)GAG>TAG	p.E57*	C10orf12_uc009xvg.1_Nonsense_Mutation_p.E367*	NM_015652	NP_056467	Q8N655	CJ012_HUMAN	hypothetical protein LOC26148	57										skin(2)	2		Colorectal(252;0.172)		Epithelial(162;6.35e-09)|all cancers(201;3.21e-07)		TGCTGACAAAGAGAATACTTT	0.413			NA											14	24					0.00244969	0.00253897	0.00245	1	0
ABCC2	1244	broad.mit.edu	37	10	101610458	101610458	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:101610458A>G	uc001kqf.2	+	31	4552	c.4413A>G	c.(4411-4413)ACA>ACG	p.T1471T		NM_000392	NP_000383	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP),	1471	Cytoplasmic (By similarity).|ABC transporter 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	ATCTAGAGACAGACAACCTCA	0.572			NA											50	22					0	0	0.00361	0	0
PKD2L1	9033	broad.mit.edu	37	10	102054763	102054763	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:102054763C>T	uc001kqx.1	-	8	1857	c.1474G>A	c.(1474-1476)GCC>ACC	p.A492T	PKD2L1_uc009xwm.1_Missense_Mutation_p.A445T	NM_016112	NP_057196	Q9P0L9	PK2L1_HUMAN	polycystic kidney disease 2-like 1	492	Helical; (Potential).				signal transduction	integral to membrane	calcium activated cation channel activity|calcium ion binding|cytoskeletal protein binding			ovary(4)	4		Colorectal(252;0.117)		Epithelial(162;6.15e-10)|all cancers(201;5.14e-08)		CCGAGTTGGGCATAGGCGAAG	0.547			NA											44	6					0	0	0.00874	0	0
KAZALD1	81621	broad.mit.edu	37	10	102822830	102822830	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:102822830A>T	uc001ksr.2	+	2	1406	c.481A>T	c.(481-483)ACT>TCT	p.T161S	KAZALD1_uc001kss.3_RNA|KAZALD1_uc001kst.1_Missense_Mutation_p.T161S	NM_030929	NP_112191	Q96I82	KAZD1_HUMAN	Kazal-type serine peptidase inhibitor domain 1	161	Kazal-like.				cell differentiation|multicellular organismal development|ossification|regulation of cell growth		insulin-like growth factor binding				0				Epithelial(162;6.21e-09)|all cancers(201;3.14e-07)		TGCCAACCTCACTGTGGCACA	0.692			NA											26	9					0	0	0.004656	0	0
FBXW4	6468	broad.mit.edu	37	10	103372211	103372211	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:103372211C>A	uc001kto.2	-	7	1206	c.860G>T	c.(859-861)GGC>GTC	p.G287V		NM_022039	NP_071322	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	287					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex				skin(1)	1		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		AAAGTCACTGCCCAAGTGTGT	0.562			NA											51	11					8.99859e-20	1.31743e-19	0.00361	1	0
CCDC147	159686	broad.mit.edu	37	10	106207461	106207461	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:106207461G>T	uc001kyh.2	+	16	2396	c.2262G>T	c.(2260-2262)AAG>AAT	p.K754N		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	754	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ACTAGGAAAAGGAGAAACTCT	0.542			NA											60	11					1.64573e-32	2.78953e-32	0.00361	1	0
SORCS1	114815	broad.mit.edu	37	10	108521397	108521397	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:108521397C>A	uc001kym.2	-	5	916	c.908G>T	c.(907-909)GGG>GTG	p.G303V	SORCS1_uc001kyl.2_Missense_Mutation_p.G303V|SORCS1_uc009xxs.2_Missense_Mutation_p.G303V|SORCS1_uc001kyn.1_Missense_Mutation_p.G303V|SORCS1_uc001kyo.2_Missense_Mutation_p.G303V	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	303	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCATCTTCTCCCAAATTCAGC	0.373			NA											18	2					1.50039e-11	1.88181e-11	0.001882	1	0
ATRNL1	26033	broad.mit.edu	37	10	116919881	116919881	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:116919881G>T	uc001lcg.2	+	6	1296	c.910G>T	c.(910-912)GGT>TGT	p.G304C	ATRNL1_uc001lce.2_RNA|ATRNL1_uc001lcf.2_Missense_Mutation_p.G304C|ATRNL1_uc009xyq.2_Missense_Mutation_p.G304C	NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	304	Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TCCTTCTGTAGGTCGGGCTTC	0.368			NA											119	19					2.09629e-50	3.82474e-50	0.00361	1	0
C10orf96	374355	broad.mit.edu	37	10	118117397	118117397	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:118117397G>T	uc001lck.2	+	7	851	c.600G>T	c.(598-600)GAG>GAT	p.E200D		NM_198515	NP_940917	P0C7W6	CJ096_HUMAN	hypothetical protein LOC374355	200										ovary(2)	2		Lung NSC(174;0.204)|all_lung(145;0.248)		all cancers(201;0.014)		AATATCTAGAGGCAGAAAAAA	0.274			NA											7	6					0.00198382	0.00205832	0.001984	1	0
HSPA12A	259217	broad.mit.edu	37	10	118464761	118464761	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:118464761T>G	uc001lct.2	-	3	260	c.155A>C	c.(154-156)CAG>CCG	p.Q52P	HSPA12A_uc001lcu.2_5'UTR	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	52							ATP binding			ovary(1)	1				all cancers(201;0.0158)		AAATGACTGCTGTTCTGAGAC	0.577			NA											35	69					0	0	0.004878	0	0
HSPA12A	259217	broad.mit.edu	37	10	118464790	118464790	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:118464790C>A	uc001lct.2	-	3	232	c.127_splice	c.e3-1	p.N43_splice	HSPA12A_uc001lcu.2_Splice_Site	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A								ATP binding			ovary(1)	1				all cancers(201;0.0158)		CAGTGTCGTTCTGCAGATATA	0.582			NA											77	24					9.90312e-32	1.67272e-31	0.00361	1	0
SEC23IP	11196	broad.mit.edu	37	10	121662451	121662451	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:121662451A>G	uc001leu.1	+	3	909	c.837A>G	c.(835-837)GTA>GTG	p.V279V	SEC23IP_uc010qtc.1_Silent_p.V68V	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	279	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GCAAGGAGGTAGAATACAAAC	0.418			NA											40	10					0	0	0.00874	0	0
DMBT1	1755	broad.mit.edu	37	10	124351009	124351009	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:124351009A>G	uc001lgk.1	+	19	2258	c.2152A>G	c.(2152-2154)ATC>GTC	p.I718V	DMBT1_uc001lgl.1_Missense_Mutation_p.I708V|DMBT1_uc001lgm.1_Intron|DMBT1_uc009xzz.1_Missense_Mutation_p.I718V|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Intron	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	718					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTTGTCGACCATCACGTTACC	0.438	Ovarian(182;93 2026 18125 22222 38972)		NA											160	43					0	0	0.00361	0	0
C10orf137	26098	broad.mit.edu	37	10	127426992	127426992	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:127426992G>T	uc001liq.1	+	15	2252	c.1959G>T	c.(1957-1959)CAG>CAT	p.Q653H	C10orf137_uc001lin.2_Missense_Mutation_p.Q619H|C10orf137_uc001lio.1_Missense_Mutation_p.Q619H|C10orf137_uc001lip.1_Missense_Mutation_p.Q357H|C10orf137_uc001lir.2_Missense_Mutation_p.Q147H|C10orf137_uc001lis.1_5'Flank	NM_015608	NP_056423	Q3B7T1	EDRF1_HUMAN	erythroid differentiation-related factor 1	653					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			ovary(5)|large_intestine(3)|lung(2)	10		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TAGAGAAGCAGATGGCCTTGT	0.428			NA											30	9					2.61193e-14	3.43638e-14	0.009535	1	0
KNDC1	85442	broad.mit.edu	37	10	135000110	135000110	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:135000110C>T	uc001llz.1	+	6	1259	c.1258C>T	c.(1258-1260)CAG>TAG	p.Q420*	KNDC1_uc001lma.1_Nonsense_Mutation_p.Q355*	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	420					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CGGTGAAGCCCAGACTCCCAG	0.657			NA											25	8					0	0	0.004289	0	0
LOC653544	653544	broad.mit.edu	37	10	135491125	135491125	+	Missense_Mutation	SNP	G	G	A	rs140402194	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:135491125G>A	uc010qvi.1	+	1	847	c.736G>A	c.(736-738)GCG>ACG	p.A246T		NM_001127389	NP_001120861	F5GZ66	F5GZ66_HUMAN	double homeobox, 4-like	246						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CCACACCGGCGCGTGGGGAAC	0.781			NA											4	12					0	0	0.001168	0	0
B4GALNT4	338707	broad.mit.edu	37	11	372748	372748	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:372748G>T	uc001lpb.2	+	3	351	c.342G>T	c.(340-342)CGG>CGT	p.R114R		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	114	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCCATGGCGGGAGGAGGTGA	0.532			NA											19	4					9.95505e-16	1.35681e-15	0.002299	1	0
MUC5B	727897	broad.mit.edu	37	11	1155780	1155780	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:1155780C>T	uc009ycr.1	+	5	594	c.468C>T	c.(466-468)GGC>GGT	p.G156G		NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	152	VWFD 1.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TGGTCAACGGCCACCCGTGAG	0.677			NA											22	5					0	0	0.005443	0	0
KRTAP5-3	387266	broad.mit.edu	37	11	1629419	1629419	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:1629419A>T	uc001ltw.1	-	1	275	c.197T>A	c.(196-198)GTC>GAC	p.V66D		NM_001012708	NP_001012726	Q6L8H2	KRA53_HUMAN	keratin associated protein 5-3	66	11 X 4 AA repeats of C-C-X-P.					keratin filament				ovary(2)	2		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000618)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)		AGAGCCACAGACCCCCTTGGA	0.672			NA											82	99					0	0	0.00361	0	0
TRIM21	6737	broad.mit.edu	37	11	4411570	4411570	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:4411570C>A	uc001lyy.1	-	2	183	c.70G>T	c.(70-72)GTG>TTG	p.V24L		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	24	RING-type.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		ACAGGCTCCACGAAGGGGTCC	0.582			NA											74	15					2.0493e-37	3.56095e-37	0.00361	1	0
OR52K2	119774	broad.mit.edu	37	11	4470577	4470577	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:4470577C>T	uc001lyz.1	+	1	8	c.8C>T	c.(7-9)GCC>GTC	p.A3V		NM_001005172	NP_001005172	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCCATGTCAGCCTCCAATATC	0.473			NA											34	7					0	0	0.003271	0	0
OR52K1	390036	broad.mit.edu	37	11	4510930	4510930	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:4510930C>T	uc001lza.1	+	1	800	c.800C>T	c.(799-801)GCC>GTC	p.A267V		NM_001005171	NP_001005171	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K,	267	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		CACCGTGTAGCCCGCCATGCT	0.512			NA											61	99					0	0	0.00361	0	0
OR52M1	119772	broad.mit.edu	37	11	4566571	4566571	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:4566571G>T	uc010qyf.1	+	1	151	c.151G>T	c.(151-153)GTA>TTA	p.V51L		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCTGGCTGTGGTAAAGATAGA	0.537			NA											55	15					2.01807e-28	3.31883e-28	0.00361	1	0
OR52R1	119695	broad.mit.edu	37	11	4825714	4825714	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:4825714A>G	uc010qym.1	-	1	134	c.134T>C	c.(133-135)ATA>ACA	p.I45T		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	Error:Variant_position_missing_in_Q8NGF1_after_alignment					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGATGGGACTATTGGATACCA	0.323			NA											31	6					0	0	0.007291	0	0
OR51F2	119694	broad.mit.edu	37	11	4843542	4843542	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:4843542G>T	uc010qyn.1	+	1	927	c.927G>T	c.(925-927)AAG>AAT	p.K309N		NM_001004753	NP_001004753	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACAGTGTAAAGATTAAGCAGA	0.383			NA											38	64					3.62531e-18	5.17825e-18	0.004289	1	0
HBE1	3046	broad.mit.edu	37	11	5289756	5289756	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:5289756A>T	uc001mal.1	-	3	640	c.387T>A	c.(385-387)GCT>GCA	p.A129A	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Silent_p.A129A	NM_005330	NP_005321	P02100	HBE_HUMAN	epsilon globin	129					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTGCCAGGCAGCCTGCACTT	0.517			NA											72	21					0	0	0.00361	0	0
OR51B4	79339	broad.mit.edu	37	11	5322292	5322292	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:5322292C>A	uc010qza.1	-	1	885	c.885G>T	c.(883-885)CAG>CAT	p.Q295H	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCTTTGAATCTGCTTGGTCT	0.433			NA											30	4					2.48696e-23	3.83861e-23	0.003271	1	0
OR51B6	390058	broad.mit.edu	37	11	5373621	5373621	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:5373621A>T	uc010qzb.1	+	1	884	c.884A>T	c.(883-885)AAG>ATG	p.K295M	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004750	NP_001004750	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B,	295	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTAAAACTAAGCAGATTCAG	0.413			NA											50	5					0	0	0.00361	0	0
OR51I2	390064	broad.mit.edu	37	11	5475259	5475259	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:5475259C>G	uc010qzf.1	+	1	541	c.541C>G	c.(541-543)CAC>GAC	p.H181D	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004754	NP_001004754	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I,	181	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTACTGCCTGCACCCAGACAT	0.458			NA											55	18					0	0	0.00361	0	0
OR52N1	79473	broad.mit.edu	37	11	5809322	5809322	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:5809322G>T	uc010qzo.1	-	1	725	c.725C>A	c.(724-726)ACC>AAC	p.T242N	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GGCAGTGCAGGTGCTGAAGGC	0.473			NA											21	41					2.54575e-18	3.64432e-18	0.010504	1	0
OR52N1	79473	broad.mit.edu	37	11	5809569	5809569	+	Missense_Mutation	SNP	G	G	T	rs149811568		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:5809569G>T	uc010qzo.1	-	1	478	c.478C>A	c.(478-480)CCT>ACT	p.P160T	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001913	NP_001001913	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N,	160	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P160S(1)		skin(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AAAGTGGAAGGGATAACAAGC	0.498			NA											35	3					1.99505e-19	2.90544e-19	0.002445	1	0
OR56B4	196335	broad.mit.edu	37	11	6129388	6129388	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:6129388A>T	uc010qzx.1	+	1	380	c.380A>T	c.(379-381)GAC>GTC	p.D127V		NM_001005181	NP_001005181	Q8NH76	O56B4_HUMAN	olfactory receptor, family 56, subfamily B,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.31e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGCAGTAGACAGATACATA	0.493			NA											91	21					0	0	0.00361	0	0
OR6A2	8590	broad.mit.edu	37	11	6816919	6816919	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:6816919A>T	uc001mes.1	-	1	221	c.21T>A	c.(19-21)AGT>AGA	p.S7R		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCACTCTCCCACTATGGTTCC	0.512			NA											19	42					0	0	0.008871	0	0
OVCH2	341277	broad.mit.edu	37	11	7712603	7712603	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:7712603G>T	uc010rbf.1	-	15	1536	c.1536C>A	c.(1534-1536)ACC>ACA	p.T512T		NM_198185	NP_937828			ovochymase 2 precursor												0				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		TCAGCACAGGGGTGGGGACAT	0.537			NA											20	8					2.21704e-12	2.82089e-12	0.00278	1	0
NLRP10	338322	broad.mit.edu	37	11	7982249	7982249	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:7982249G>T	uc001mfv.1	-	2	927	c.910C>A	c.(910-912)CTG>ATG	p.L304M		NM_176821	NP_789791	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	304	NACHT.						ATP binding			lung(4)|ovary(2)|pancreas(1)|kidney(1)|skin(1)	9				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GCTTGTTTCAGCAAGGGCTCC	0.552			NA											83	19					2.35699e-46	4.24433e-46	0.00361	1	0
SWAP70	23075	broad.mit.edu	37	11	9749606	9749606	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:9749606A>G	uc001mhw.2	+	5	748	c.649A>G	c.(649-651)ATG>GTG	p.M217V	SWAP70_uc001mhv.2_Missense_Mutation_p.M217V|SWAP70_uc001mhx.2_Missense_Mutation_p.M159V	NM_015055	NP_055870	Q9UH65	SWP70_HUMAN	SWAP-70 protein	217	PH.					cytoplasm|lamellipodium|nucleus|plasma membrane	calcium ion binding|DNA binding			ovary(2)|central_nervous_system(1)	3				all cancers(16;1.21e-10)|Epithelial(150;2.81e-09)|BRCA - Breast invasive adenocarcinoma(625;0.00649)		ACAGGGTTACATGATGAAAAA	0.338			NA											27	1					0	0	0.004656	0	0
INSC	387755	broad.mit.edu	37	11	15197325	15197325	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:15197325T>A	uc001mly.2	+	3	282	c.236T>A	c.(235-237)ATG>AAG	p.M79K	INSC_uc001mlz.2_Missense_Mutation_p.M32K|INSC_uc001mma.2_Missense_Mutation_p.M32K|INSC_uc010rcs.1_Missense_Mutation_p.M32K|INSC_uc001mmb.2_Missense_Mutation_p.M32K|INSC_uc001mmc.2_Missense_Mutation_p.M32K	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	79					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CAGCGCTGGATGGAAGATCTG	0.537			NA											22	9					0	0	0.00278	0	0
ABCC8	6833	broad.mit.edu	37	11	17485047	17485047	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:17485047C>A	uc001mnc.2	-	4	643	c.517G>T	c.(517-519)GGG>TGG	p.G173W	ABCC8_uc010rcy.1_Missense_Mutation_p.G173W	NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	173	Helical; Name=5; (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACCAGCAGCCCTGTGAGGCAG	0.582			NA											9	0					0.000274275	0.000290021	0.004482	1	0
TSG101	7251	broad.mit.edu	37	11	18528444	18528444	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:18528444C>T	uc001mor.2	-	6	634	c.508G>A	c.(508-510)GGA>AGA	p.G170R	TSG101_uc001mos.1_Missense_Mutation_p.G118R|TSG101_uc009yhs.1_RNA	NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	170					cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0						GGAGAGATTCCACCTGGCATG	0.353	GBM(99;1348 1396 8611 26475 50572)		NA											18	32					0	0	0.002299	0	0
IGSF22	283284	broad.mit.edu	37	11	18731902	18731902	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:18731902G>C	uc009yht.2	-	17	2863	c.2673C>G	c.(2671-2673)TCC>TCG	p.S891S	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment										ovary(4)|large_intestine(2)|kidney(1)	7						CTACTGAGCTGGATGGCACAC	0.493			NA											67	20					0	0	0.00361	0	0
IGSF22	283284	broad.mit.edu	37	11	18740226	18740226	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:18740226G>T	uc009yht.2	-	8	936	c.746C>A	c.(745-747)ACC>AAC	p.T249N	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	249	Ig-like 2.									ovary(4)|large_intestine(2)|kidney(1)	7						GACCACTGTGGTGTCAACCTT	0.478			NA											125	32					3.78446e-69	7.05801e-69	0.00361	1	0
ANO3	63982	broad.mit.edu	37	11	26556081	26556081	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:26556081C>G	uc001mqt.3	+	9	1093	c.948C>G	c.(946-948)ACC>ACG	p.T316T	ANO3_uc010rdr.1_Silent_p.T300T|ANO3_uc010rds.1_Silent_p.T155T|ANO3_uc010rdt.1_Silent_p.T170T	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	316	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TGGAACGCACCAAATATGAAA	0.323			NA											43	8					0	0	0.00361	0	0
ANO3	63982	broad.mit.edu	37	11	26664763	26664763	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:26664763G>T	uc001mqt.3	+	23	2455	c.2310G>T	c.(2308-2310)GCG>GCT	p.A770A	ANO3_uc010rdr.1_Silent_p.A754A|ANO3_uc010rds.1_Silent_p.A609A|ANO3_uc010rdt.1_Silent_p.A624A	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	770	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTTTGTTGCGGCTTTTCCTC	0.368			NA											33	12					4.90274e-10	5.9485e-10	0.00623	1	0
KCNA4	3739	broad.mit.edu	37	11	30033117	30033117	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:30033117G>T	uc001msk.2	-	2	2261	c.1109C>A	c.(1108-1110)CCC>CAC	p.P370H		NM_002233	NP_002224	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related	370						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GATGAAGAAGGGGTCATTGAA	0.478			NA											36	3					2.48696e-23	3.83861e-23	0.003271	1	0
MPPED2	744	broad.mit.edu	37	11	30601890	30601890	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:30601890C>A	uc001msr.2	-	1	151	c.31G>T	c.(31-33)GTT>TTT	p.V11F	MPPED2_uc001msq.3_Missense_Mutation_p.V11F|MPPED2_uc009yji.2_5'UTR	NM_001584	NP_001575	Q15777	MPPD2_HUMAN	metallophosphoesterase domain containing 2	11					nervous system development		hydrolase activity|metal ion binding			skin(1)	1						GTTATGGTAACTTTGCCTTGA	0.478			NA											42	8					4.44401e-20	6.55085e-20	0.002522	1	0
LRRC4C	57689	broad.mit.edu	37	11	40137665	40137665	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:40137665C>A	uc001mxa.1	-	2	2142	c.178G>T	c.(178-180)GTG>TTG	p.V60L	LRRC4C_uc001mxc.1_Missense_Mutation_p.V56L|LRRC4C_uc001mxd.1_Missense_Mutation_p.V56L|LRRC4C_uc001mxb.1_Missense_Mutation_p.V56L	NM_020929	NP_065980	Q9HCJ2	LRC4C_HUMAN	netrin-G1 ligand precursor	60	LRRNT.				regulation of axonogenesis	integral to membrane	protein binding			ovary(4)|skin(3)|central_nervous_system(1)	8		all_lung(304;0.0575)|Lung NSC(402;0.138)				ACACAAATCACCTTGCTGAAC	0.542			NA											16	21					2.23348e-06	2.47965e-06	0.004007	1	0
PHF21A	51317	broad.mit.edu	37	11	45992717	45992717	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:45992717C>A	uc001ncc.3	-	7	1186	c.562G>T	c.(562-564)GGG>TGG	p.G188W	PHF21A_uc001ncb.3_Missense_Mutation_p.G188W|PHF21A_uc009ykx.2_Missense_Mutation_p.G188W|PHF21A_uc001nce.2_Missense_Mutation_p.G188W|PHF21A_uc001nca.1_5'UTR	NM_001101802	NP_001095272	Q96BD5	PF21A_HUMAN	BRAF35/HDAC2 complex isoform a	188					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						GCCCCAGGCCCAGTGACCTTA	0.512			NA											41	6					9.9191e-30	1.64949e-29	0.00874	1	0
HARBI1	283254	broad.mit.edu	37	11	46625147	46625147	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:46625147T>C	uc001ncy.2	-	3	1231	c.983A>G	c.(982-984)CAC>CGC	p.H328R		NM_173811	NP_776172	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	328						cytoplasm|nucleus	metal ion binding|nuclease activity				0						GGACTCCATGTGCTCATACTC	0.522			NA											50	12					0	0	0.00361	0	0
ACP2	53	broad.mit.edu	37	11	47269242	47269242	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:47269242G>C	uc001nei.2	-	3	364	c.247C>G	c.(247-249)CTG>GTG	p.L83V	ACP2_uc010rhe.1_Missense_Mutation_p.L55V|ACP2_uc009ylj.2_Missense_Mutation_p.L11V|ACP2_uc010rhf.1_Missense_Mutation_p.L51V|ACP2_uc010rhg.1_Missense_Mutation_p.L83V|ACP2_uc010rhh.1_5'UTR|ACP2_uc010rhi.1_5'UTR|ACP2_uc009ylk.2_Missense_Mutation_p.L83V|ACP2_uc010rhj.1_Missense_Mutation_p.L83V|NR1H3_uc009yll.1_5'Flank|NR1H3_uc010rhk.1_5'Flank|NR1H3_uc001nek.2_5'Flank|NR1H3_uc001nej.2_5'Flank|NR1H3_uc001nel.2_5'Flank	NM_001610	NP_001601	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal isoform 1	83	Lumenal (Potential).					integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity			ovary(1)	1						CGCTGCCGCAGGGCCTGGCCC	0.592	Melanoma(90;262 1440 11488 44828 48531)		NA											18	42					0	0	0.008871	0	0
MYBPC3	4607	broad.mit.edu	37	11	47364673	47364673	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:47364673G>A	uc001nfa.3	-	14	1305	c.1250C>T	c.(1249-1251)GCC>GTC	p.A417V	MYBPC3_uc010rhl.1_RNA	NM_000256	NP_000247	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	416	Ig-like C2-type 2.		A -> S (in CMH4).		cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			ovary(2)|central_nervous_system(1)	3				Lung(87;0.176)		GGTACGCTTGGCACCGATGGA	0.617			NA											11	0					0	0	0.001855	0	0
FNBP4	23360	broad.mit.edu	37	11	47772725	47772725	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:47772725T>G	uc009ylv.2	-	5	908	c.755A>C	c.(754-756)CAG>CCG	p.Q252P	FNBP4_uc001ngj.2_Missense_Mutation_p.Q159P|FNBP4_uc001ngl.2_RNA	NM_015308	NP_056123	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	252										ovary(1)	1						TCCCTGTACCTGTGTGGCAAG	0.388			NA											58	11					0	0	0.00361	0	0
OR4B1	119765	broad.mit.edu	37	11	48238445	48238445	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:48238445G>T	uc010rhs.1	+	1	84	c.84G>T	c.(82-84)GTG>GTT	p.V28V		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	28	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						GCTTTGTGGTGTTTCTCCCCG	0.493			NA											90	18					2.41567e-30	4.03445e-30	0.00361	1	0
OR4X2	119764	broad.mit.edu	37	11	48267347	48267347	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:48267347C>A	uc001ngs.1	+	1	692	c.692C>A	c.(691-693)ACC>AAC	p.T231N		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	231	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GCCCTCTCCACCTGTGGGTCC	0.522			NA											50	9					5.73435e-26	9.20351e-26	0.00361	1	0
FOLH1	2346	broad.mit.edu	37	11	49175458	49175458	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:49175458T>C	uc001ngy.2	-	17	2171	c.1910A>G	c.(1909-1911)AAG>AGG	p.K637R	FOLH1_uc001ngx.2_Missense_Mutation_p.K69R|FOLH1_uc001ngz.2_Missense_Mutation_p.K637R|FOLH1_uc009yly.2_Missense_Mutation_p.K622R|FOLH1_uc009ylz.2_Missense_Mutation_p.K622R|FOLH1_uc009yma.2_Missense_Mutation_p.K329R	NM_004476	NP_004467	Q04609	FOLH1_HUMAN	folate hydrolase 1 isoform 1	637	Extracellular (Probable).				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			large_intestine(1)|ovary(1)|skin(1)	3					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TGTAAAATTCTTTACTGCAGA	0.284			NA											9	36					0	0	0.004482	0	0
LOC440040	440040	broad.mit.edu	37	11	49598110	49598110	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:49598110G>T	uc010rhy.1	+	2	701	c.223G>T	c.(223-225)GCC>TCC	p.A75S	LOC440040_uc009ymb.2_Missense_Mutation_p.A75S	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						TTCGGCTGTGGCCCTAGAGCA	0.522			NA											10	14					0.000442599	0.000466224	0.006214	1	0
LOC440040	440040	broad.mit.edu	37	11	49598375	49598375	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:49598375C>A	uc010rhy.1	+	2	966	c.488C>A	c.(487-489)CCT>CAT	p.P163H	LOC440040_uc009ymb.2_Missense_Mutation_p.P163H	NR_027044				SubName: Full=cDNA FLJ60249, highly similar to Metabotropic glutamate receptor 5;												0						AGGGTTGTGCCTTCAGATGCT	0.453			NA											29	32					1.39806e-14	1.85576e-14	0.008361	1	0
OR4A5	81318	broad.mit.edu	37	11	51411670	51411670	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:51411670G>C	uc001nhi.1	-	1	726	c.726C>G	c.(724-726)ACC>ACG	p.T242T		NM_001005272	NP_001005272	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T242T(1)		ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(304;0.236)				GGACAACAACGGTACTGCCGG	0.398			NA											32	13					0	0	0.002445	0	0
TRIM48	79097	broad.mit.edu	37	11	55032418	55032418	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55032418C>G	uc010rid.1	+	2	173	c.87C>G	c.(85-87)CTC>CTG	p.L29L		NM_024114	NP_077019	Q8IWZ4	TRI48_HUMAN	tripartite motif-containing 48	13						intracellular	zinc ion binding				0						AGAGGGAACTCACCTGCCCCA	0.488			NA											79	224					0	0	0.00361	0	0
OR4C15	81309	broad.mit.edu	37	11	55322199	55322199	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55322199C>G	uc010rig.1	+	1	417	c.417C>G	c.(415-417)CTC>CTG	p.L139L		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	85	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TAGACTCCCTCTATGTGACAA	0.488			NA								HNSCC(20;0.049)			49	128					0	0	0.00361	0	0
OR4C15	81309	broad.mit.edu	37	11	55322684	55322684	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55322684T>G	uc010rig.1	+	1	902	c.902T>G	c.(901-903)ATT>AGT	p.I301S		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						GCTGTTGTGATTTTGTTCTTT	0.428			NA								HNSCC(20;0.049)			42	112					0	0	0.00874	0	0
OR4P4	81300	broad.mit.edu	37	11	55406660	55406660	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55406660T>C	uc010rij.1	+	1	827	c.827T>C	c.(826-828)ATT>ACT	p.I276T		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	276	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						TATACCATCATTGCTCCCATG	0.398			NA											11	66					0	0	0.000978	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735354	55735354	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55735354C>A	uc010rit.1	-	1	586	c.586G>T	c.(586-588)GTG>TTG	p.V196L		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	196	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					GTGATAAACACCACCGCTACT	0.383			NA											17	19					3.45872e-05	3.74953e-05	0.004007	1	0
OR8H3	390152	broad.mit.edu	37	11	55890462	55890462	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55890462C>A	uc001nii.1	+	1	614	c.614C>A	c.(613-615)TCC>TAC	p.S205Y		NM_001005201	NP_001005201	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H,	205	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00693)					ATCGCTGGTTCCACCCTGATG	0.408			NA											65	66					2.54232e-27	4.13527e-27	0.00361	1	0
OR8J3	81168	broad.mit.edu	37	11	55904345	55904345	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:55904345T>C	uc010riz.1	-	1	850	c.850A>G	c.(850-852)ATG>GTG	p.M284V		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	284	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GGATTCAGCATAGGAATCACC	0.363			NA											24	57					0	0	0.002299	0	0
OR5R1	219479	broad.mit.edu	37	11	56185423	56185423	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:56185423C>G	uc010rji.1	-	1	286	c.286G>C	c.(286-288)GCT>CCT	p.A96P		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	96	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTTGCACAAGCATGGAAAGGA	0.478			NA											9	34					0	0	0.006214	0	0
OR5R1	219479	broad.mit.edu	37	11	56185700	56185700	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:56185700T>A	uc010rji.1	-	1	9	c.9A>T	c.(7-9)GAA>GAT	p.E3D		NM_001004744	NP_001004744	Q8NH85	OR5R1_HUMAN	olfactory receptor, family 5, subfamily R,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					TGATATTAACTTCAGCCATTT	0.388			NA											29	66					0	0	0.008361	0	0
OR5M9	390162	broad.mit.edu	37	11	56230457	56230457	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:56230457G>T	uc010rjj.1	-	1	421	c.421C>A	c.(421-423)CGG>AGG	p.R141R		NM_001004743	NP_001004743	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M,	141	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					GAGATGAGCCGAACACACACA	0.458			NA											34	26					1.836e-18	2.63219e-18	0.003755	1	0
OR5M8	219484	broad.mit.edu	37	11	56258458	56258458	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:56258458A>T	uc001nix.1	-	1	389	c.389T>A	c.(388-390)CTT>CAT	p.L130H		NM_001005282	NP_001005282	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M,	130	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	Esophageal squamous(21;0.00352)					GCTGCCATAAAGCAGAGGGTT	0.517			NA											53	48					0	0	0.00361	0	0
OR5AP2	338675	broad.mit.edu	37	11	56409178	56409178	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:56409178G>A	uc001njb.1	-	1	738	c.738C>T	c.(736-738)ACC>ACT	p.T246T		NM_001002925	NP_001002925	Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP,	246	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4						AAGAGGCACAGGTGGAGAAGG	0.468			NA											61	38					0	0	0.00361	0	0
SMTNL1	219537	broad.mit.edu	37	11	57310583	57310583	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:57310583C>A	uc009ymh.1	+	2	522	c.522C>A	c.(520-522)GAC>GAA	p.D174E		NM_001105565	NP_001099035	E9PPJ3	E9PPJ3_HUMAN	smoothelin-like 1	156										ovary(1)	1						ATGCCAATGACAGAGACAAGC	0.552			NA											12	12					7.03913e-09	8.36735e-09	0.001368	1	0
OR9I1	219954	broad.mit.edu	37	11	57886019	57886019	+	Missense_Mutation	SNP	C	C	A	rs147763350		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:57886019C>A	uc001nml.1	-	1	898	c.898G>T	c.(898-900)GCC>TCC	p.A300S	OR9Q1_uc001nmj.2_Intron	NM_001005211	NP_001005211	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I,	300	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1		Breast(21;0.0589)				TTTCTGAAGGCGTCTTTTACA	0.428			NA											44	124					1.00776e-21	1.52623e-21	0.00361	1	0
OR5B17	219965	broad.mit.edu	37	11	58126271	58126271	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:58126271G>T	uc010rke.1	-	1	272	c.272C>A	c.(271-273)TCC>TAC	p.S91Y		NM_001005489	NP_001005489	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B,	91	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGCACTGTAGGAGATGGCTTT	0.463			NA											34	16					5.91797e-21	8.87925e-21	0.002445	1	0
OR5B3	441608	broad.mit.edu	37	11	58170323	58170323	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:58170323C>A	uc010rkf.1	-	1	560	c.560G>T	c.(559-561)TGC>TTC	p.C187F		NM_001005469	NP_001005469	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				TCTATCAGAGCAAGAGAGAAC	0.388			NA											45	18					4.44401e-20	6.55085e-20	0.002522	1	0
OR5B21	219968	broad.mit.edu	37	11	58274827	58274827	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:58274827G>T	uc010rki.1	-	1	752	c.752C>A	c.(751-753)ACA>AAA	p.T251K		NM_001005218	NP_001005218	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B,	251	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GAAGATGATTGTGCCATAGAA	0.473			NA											24	60					3.01185e-09	3.59563e-09	0.003954	1	0
LPXN	9404	broad.mit.edu	37	11	58317280	58317280	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:58317280C>T	uc001nmw.2	-	7	866	c.721G>A	c.(721-723)GGA>AGA	p.G241R	LPXN_uc009ymp.2_Missense_Mutation_p.G111R|LPXN_uc010rkj.1_Missense_Mutation_p.G246R|LPXN_uc010rkk.1_Missense_Mutation_p.G221R	NM_004811	NP_004802	O60711	LPXN_HUMAN	leupaxin isoform 2	241	LIM zinc-binding 2.				cell adhesion|protein complex assembly|signal transduction	cytoplasm	zinc ion binding			ovary(1)	1		Breast(21;0.00725)|all_epithelial(135;0.0101)|all_lung(304;0.24)				AACACCTCTCCGCAGTGAGAG	0.498			NA											13	18					0	0	0.003163	0	0
FAM111A	63901	broad.mit.edu	37	11	58919341	58919341	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:58919341C>T	uc010rkp.1	+	5	427	c.200C>T	c.(199-201)CCA>CTA	p.P67L	FAM111A_uc010rkq.1_Missense_Mutation_p.P67L|FAM111A_uc010rkr.1_Missense_Mutation_p.P67L|FAM111A_uc001nno.2_Missense_Mutation_p.P67L|FAM111A_uc001nnp.2_Missense_Mutation_p.P67L|FAM111A_uc001nnq.2_Missense_Mutation_p.P67L	NM_001142521	NP_001135993	Q96PZ2	F111A_HUMAN	hypothetical protein LOC63901	67					proteolysis		serine-type endopeptidase activity			ovary(3)	3		all_epithelial(135;0.139)				AAGAAAAATCCAGAAGACCAG	0.408			NA											35	94					0	0	0.004878	0	0
OR4D11	219986	broad.mit.edu	37	11	59271521	59271521	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:59271521T>A	uc001noa.1	+	1	473	c.473T>A	c.(472-474)GTG>GAG	p.V158E		NM_001004706	NP_001004706	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CACTCCATCGTGCAGATCTCC	0.547			NA											117	86					0	0	0.00361	0	0
OR10V1	390201	broad.mit.edu	37	11	59480963	59480963	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:59480963A>C	uc001nof.1	-	1	356	c.356T>G	c.(355-357)ATG>AGG	p.M119R		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GTCATAAGCCATGACTACCAG	0.512			NA											15	21					0	0	0.002445	0	0
OR10V1	390201	broad.mit.edu	37	11	59480965	59480965	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:59480965G>T	uc001nof.1	-	1	354	c.354C>A	c.(352-354)GTC>GTA	p.V118V		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CATAAGCCATGACTACCAGCA	0.512			NA											15	21					7.11191e-15	9.49891e-15	0.002836	1	0
MS4A4A	51338	broad.mit.edu	37	11	60064772	60064772	+	Missense_Mutation	SNP	G	G	T	rs140018712		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:60064772G>T	uc001noz.2	+	3	314	c.304G>T	c.(304-306)GGG>TGG	p.G102W	MS4A4A_uc001npa.2_Missense_Mutation_p.G83W|MS4A4A_uc001npb.2_Missense_Mutation_p.G83W|MS4A4A_uc001npc.2_Missense_Mutation_p.G83W	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	102	Helical; (Potential).					integral to membrane	receptor activity				0						CGTGTATATCGGGTACACAAT	0.388			NA											35	21					8.73648e-17	1.21034e-16	0.004289	1	0
C11orf9	745	broad.mit.edu	37	11	61553285	61553285	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:61553285G>A	uc001nsc.1	+	26	3410	c.3314G>A	c.(3313-3315)CGG>CAG	p.R1105Q	C11orf9_uc001nse.1_Missense_Mutation_p.R1065Q|C11orf9_uc010rll.1_Missense_Mutation_p.R491Q	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	1105					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						ACCTCTCACCGGTGGCCAATA	0.617			NA											26	60					0	0	0.00632	0	0
AHNAK	79026	broad.mit.edu	37	11	62284959	62284959	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:62284959C>A	uc001ntl.2	-	5	17230	c.16930G>T	c.(16930-16932)GGG>TGG	p.G5644W	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	5644	Gly-rich.				nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTGAGGCCCAGACACACTC	0.502			NA											52	105					1.35964e-18	1.9565e-18	0.00361	1	0
NRXN2	9379	broad.mit.edu	37	11	64434732	64434732	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:64434732A>G	uc001oar.2	-	10	2227	c.1788T>C	c.(1786-1788)GAT>GAC	p.D596D	NRXN2_uc001oas.2_Silent_p.D565D|NRXN2_uc001oaq.2_Silent_p.D263D	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CTTTTCGCCCATCCCTCTGGA	0.592			NA											16	47					0	0	0.003163	0	0
PYGM	5837	broad.mit.edu	37	11	64525786	64525786	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:64525786C>A	uc001oax.3	-	4	1277	c.460G>T	c.(460-462)GCC>TCC	p.A154S	PYGM_uc001oay.3_Intron	NM_005609	NP_005600	P11217	PYGM_HUMAN	muscle glycogen phosphorylase isoform 1	154					glucose metabolic process|glycogen catabolic process	cytosol	glycogen phosphorylase activity|protein binding			ovary(2)	2					Pyridoxal Phosphate(DB00114)	CCATAGGCGGCCAGGCCCAGT	0.602			NA											87	60					3.59392e-34	6.15646e-34	0.00361	1	0
ATG2A	23130	broad.mit.edu	37	11	64676542	64676542	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:64676542G>A	uc001obx.2	-	16	2400	c.2285C>T	c.(2284-2286)TCA>TTA	p.S762L		NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	762							protein binding			ovary(1)|central_nervous_system(1)	2						ACTCTCCACTGACAGCTCCAG	0.622			NA											19	36					0	0	0.007413	0	0
PPP2R5B	5526	broad.mit.edu	37	11	64695896	64695896	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:64695896C>T	uc001oby.2	+	6	1306	c.721C>T	c.(721-723)CGG>TGG	p.R241W	PPP2R5B_uc001obz.2_Missense_Mutation_p.R241W	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	241					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CATCTTCCTCCGGTGAGTGGC	0.517			NA											63	43					0	0	0.00361	0	0
BATF2	116071	broad.mit.edu	37	11	64756939	64756939	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:64756939C>T	uc001ocf.1	-	3	618	c.487G>A	c.(487-489)GTT>ATT	p.V163I	BATF2_uc001oce.1_Missense_Mutation_p.V78I	NM_138456	NP_612465	Q8N1L9	BATF2_HUMAN	basic leucine zipper transcription factor,	163						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGTTCAGCAACCACAGCGGGG	0.632			NA											20	8					0	0	0.007413	0	0
SPDYC	387778	broad.mit.edu	37	11	64938797	64938797	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:64938797G>T	uc010rnz.1	+	2	27	c.27_splice	c.e2-1	p.G9_splice		NM_001008778	NP_001008778	Q5MJ68	SPDYC_HUMAN	speedy C						cell cycle	nucleus	protein kinase binding				0						TTTCTCTACAGGTCACCCTGC	0.592			NA											62	138					5.10652e-33	8.70133e-33	0.00361	1	0
POLA2	23649	broad.mit.edu	37	11	65055292	65055292	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:65055292G>T	uc001odj.2	+	11	1454	c.1112G>T	c.(1111-1113)CGG>CTG	p.R371L	POLA2_uc010rod.1_Missense_Mutation_p.R163L|POLA2_uc001odk.2_Missense_Mutation_p.R68L	NM_002689	NP_002680	Q14181	DPOA2_HUMAN	DNA-directed DNA polymerase alpha 2	371					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding				0					Dacarbazine(DB00851)	AACCATGACCGGCCAGATGTC	0.493			NA											29	18					5.91797e-21	8.87925e-21	0.002445	1	0
PCNXL3	399909	broad.mit.edu	37	11	65387346	65387346	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:65387346G>T	uc001oey.2	+	8	1951	c.1951G>T	c.(1951-1953)GCC>TCC	p.A651S		NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	651						integral to membrane					0						TGTGCATGAGGCCTGCACCTT	0.642			NA											8	13					0.000157383	0.000167241	0.00308	1	0
PCNXL3	399909	broad.mit.edu	37	11	65391686	65391686	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:65391686G>C	uc001oey.2	+	14	2565	c.2565G>C	c.(2563-2565)GCG>GCC	p.A855A	PCNXL3_uc009yqn.2_5'Flank|PCNXL3_uc001oez.2_5'Flank	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	855	Helical; (Potential).					integral to membrane					0						GGGTGATCGCGTACAGCCGTC	0.637			NA											6	16					0	0	0.001984	0	0
SF3B2	10992	broad.mit.edu	37	11	65826990	65826990	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:65826990A>G	uc001ogy.1	+	12	1365	c.1325A>G	c.(1324-1326)AAG>AGG	p.K442R		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	442					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						TTCTAGGAAAAGAAGCCAGAA	0.502			NA											30	72					0	0	0.008361	0	0
TMEM151A	256472	broad.mit.edu	37	11	66062088	66062088	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:66062088C>A	uc001ohl.2	+	2	483	c.371C>A	c.(370-372)TCC>TAC	p.S124Y		NM_153266	NP_694998	Q8N4L1	T151A_HUMAN	transmembrane protein 151A	124						integral to membrane				central_nervous_system(1)	1						CACGTGCGGTCCTGCCAGGCG	0.687			NA											9	23					0.000442599	0.000466224	0.006214	1	0
TBX10	347853	broad.mit.edu	37	11	67402313	67402313	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67402313G>A	uc001omp.2	-	3	439	c.351C>T	c.(349-351)TTC>TTT	p.F117F		NM_005995	NP_005986	O75333	TBX10_HUMAN	T-box 10	117	T-box.				anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						CCAGGGGGATGAAGTCCATGA	0.632			NA											25	51					0	0	0.003954	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925397	67925397	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67925397G>C	uc001onm.1	-	11	2672	c.2416C>G	c.(2416-2418)CTT>GTT	p.L806V	SUV420H1_uc009yse.1_Missense_Mutation_p.L392V|SUV420H1_uc001onn.1_Missense_Mutation_p.L634V|SUV420H1_uc009ysf.2_Missense_Mutation_p.L566V	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	806					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						AAGAGAGAAAGAGGATCACTG	0.438			NA											140	107					0	0	0.00361	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925427	67925427	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67925427G>A	uc001onm.1	-	11	2642	c.2386C>T	c.(2386-2388)CAT>TAT	p.H796Y	SUV420H1_uc009yse.1_Missense_Mutation_p.H382Y|SUV420H1_uc001onn.1_Missense_Mutation_p.H624Y|SUV420H1_uc009ysf.2_Missense_Mutation_p.H556Y	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	796					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						CCATTTTCATGAAGCCCCTCT	0.408			NA											154	115					0	0	0.00361	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925554	67925554	+	Silent	SNP	G	G	A	rs146549090	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67925554G>A	uc001onm.1	-	11	2515	c.2259C>T	c.(2257-2259)AAC>AAT	p.N753N	SUV420H1_uc009yse.1_Silent_p.N339N|SUV420H1_uc001onn.1_Silent_p.N581N|SUV420H1_uc009ysf.2_Silent_p.N513N	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	753					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						GATTGTTATCGTTGTCATGGT	0.363			NA											106	96					0	0	0.00361	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925786	67925786	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67925786G>A	uc001onm.1	-	11	2283	c.2027C>T	c.(2026-2028)TCA>TTA	p.S676L	SUV420H1_uc009yse.1_Missense_Mutation_p.S262L|SUV420H1_uc001onn.1_Missense_Mutation_p.S504L|SUV420H1_uc009ysf.2_Missense_Mutation_p.S436L	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	676					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						TGTCACAACTGAACAACCGAC	0.473			NA											36	26					0	0	0.003271	0	0
SUV420H1	51111	broad.mit.edu	37	11	67926066	67926066	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67926066G>T	uc001onm.1	-	11	2003	c.1747C>A	c.(1747-1749)CCT>ACT	p.P583T	SUV420H1_uc009yse.1_Missense_Mutation_p.P169T|SUV420H1_uc001onn.1_Missense_Mutation_p.P411T|SUV420H1_uc009ysf.2_Missense_Mutation_p.P343T	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						TGCAGCACAGGAGCTGGCTGC	0.507			NA											89	53					7.68447e-34	1.3152e-33	0.00361	1	0
SUV420H1	51111	broad.mit.edu	37	11	67926533	67926533	+	Missense_Mutation	SNP	G	G	C	rs71459689		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67926533G>C	uc001onm.1	-	11	1536	c.1280C>G	c.(1279-1281)TCT>TGT	p.S427C	SUV420H1_uc009yse.1_Missense_Mutation_p.S13C|SUV420H1_uc001onn.1_Missense_Mutation_p.S255C|SUV420H1_uc009ysf.2_Missense_Mutation_p.S187C	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	427					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						AGTTAGCTTAGATGAGGTAGA	0.378			NA											43	31					0	0	0.002522	0	0
SUV420H1	51111	broad.mit.edu	37	11	67926536	67926536	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:67926536G>A	uc001onm.1	-	11	1533	c.1277C>T	c.(1276-1278)TCA>TTA	p.S426L	SUV420H1_uc009yse.1_Missense_Mutation_p.S12L|SUV420H1_uc001onn.1_Missense_Mutation_p.S254L|SUV420H1_uc009ysf.2_Missense_Mutation_p.S186L	NM_017635	NP_060105	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 isoform	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(2)|kidney(1)	3						TAGCTTAGATGAGGTAGAGTT	0.368			NA											41	31					0	0	0.007835	0	0
MYEOV	26579	broad.mit.edu	37	11	69063426	69063426	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:69063426G>T	uc001oov.2	+	3	959	c.509G>T	c.(508-510)AGA>ATA	p.R170I	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.R170I|MYEOV_uc001oow.2_Missense_Mutation_p.R112I	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	170											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GAAGCCTTTAGAGTGGGCGTT	0.582			NA											69	184					5.22007e-41	9.25354e-41	0.00361	1	0
FGF4	2249	broad.mit.edu	37	11	69589549	69589549	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:69589549C>A	uc001opg.1	-	1	623	c.304G>T	c.(304-306)GGC>TGC	p.G102C	FGF4_uc010rqj.1_Missense_Mutation_p.G102C	NM_002007	NP_001998	P08620	FGF4_HUMAN	fibroblast growth factor 4 precursor	102					cell-cell signaling|chondroblast differentiation|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|mesenchymal cell proliferation|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade	extracellular region	growth factor activity|heparin binding				0	Melanoma(5;1.89e-05)		LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)		Pentosan Polysulfate(DB00686)	CCGATGCGGCCGTCGGGGAGC	0.771			NA											4	2					1.23904e-05	1.35614e-05	0.000602	1	0
PPFIA1	8500	broad.mit.edu	37	11	70171001	70171001	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:70171001C>G	uc001opo.2	+	4	613	c.415C>G	c.(415-417)CTT>GTT	p.L139V	PPFIA1_uc001opn.1_Missense_Mutation_p.L139V|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_5'Flank	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	139	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGAGCGGTCTCTTAGGATGAC	0.448			NA											56	145					0	0	0.00361	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73071371	73071371	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:73071371G>T	uc001otu.2	+	11	4234	c.4213G>T	c.(4213-4215)GAC>TAC	p.D1405Y		NM_014786	NP_055601	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1405					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity				0						ACAGAGCCTGGACGATGCACT	0.637			NA											30	100					5.97227e-30	9.94007e-30	0.002096	1	0
CHRDL2	25884	broad.mit.edu	37	11	74413894	74413894	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:74413894G>T	uc001ovi.2	-	9	1318	c.1065C>A	c.(1063-1065)GCC>GCA	p.A355A	CHRDL2_uc001ovg.2_Silent_p.A239A|CHRDL2_uc001ovh.2_Silent_p.A355A|CHRDL2_uc001ovj.1_RNA|CHRDL2_uc001ovk.1_Silent_p.A290A			Q6WN34	CRDL2_HUMAN	RecName: Full=Chordin-like protein 2; AltName: Full=Chordin-related protein 2; AltName: Full=Breast tumor novel factor 1;          Short=BNF-1; Flags: Precursor;	355					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion					0	Hepatocellular(1;0.098)					CGTGTTCCAGGGCAAAGCGAC	0.612			NA									OREG0021223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	37					3.33393e-15	4.49953e-15	0.004878	1	0
MAP6	4135	broad.mit.edu	37	11	75298606	75298606	+	Missense_Mutation	SNP	G	G	A	rs140994962	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:75298606G>A	uc001owu.2	-	4	2005	c.1940C>T	c.(1939-1941)CCG>CTG	p.P647L		NM_033063	NP_149052	Q96JE9	MAP6_HUMAN	microtubule-associated protein 6 isoform 1	647	Pro-rich.					Golgi apparatus|microtubule|perinuclear region of cytoplasm	calmodulin binding				0	Ovarian(111;0.11)					TTCATCCTTCGGATGCTCTGG	0.517	Esophageal Squamous(181;1115 2007 8647 17065 22697)		NA											103	68					0	0	0.00361	0	0
OMP	4975	broad.mit.edu	37	11	76814343	76814343	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:76814343A>G	uc010rsk.1	+	1	458	c.458A>G	c.(457-459)AAC>AGC	p.N153S	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	153					sensory perception of smell|synaptic transmission						0						GAGCCCGCCAACCTCAAGGCC	0.632			NA											70	49					0	0	0.00361	0	0
ODZ4	26011	broad.mit.edu	37	11	78383237	78383237	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:78383237G>T	uc001ozl.3	-	31	6097	c.5634C>A	c.(5632-5634)AGC>AGA	p.S1878R	ODZ4_uc001ozk.3_Missense_Mutation_p.S103R|ODZ4_uc009yvb.1_Missense_Mutation_p.S462R	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1878	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CATTCAGCCTGCTGCTGGGTG	0.577			NA											14	38					6.31663e-08	7.33275e-08	0.003163	1	0
SYTL2	54843	broad.mit.edu	37	11	85438967	85438967	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:85438967T>A	uc010rth.1	-	7	1707	c.1431A>T	c.(1429-1431)CCA>CCT	p.P477P	SYTL2_uc010rtg.1_Silent_p.P478P|SYTL2_uc010rti.1_Silent_p.P477P|SYTL2_uc010rtj.1_Silent_p.P429P|SYTL2_uc009yvj.2_5'Flank|SYTL2_uc001pbd.2_5'Flank|SYTL2_uc001pbb.2_5'Flank|SYTL2_uc001pbc.2_5'Flank|SYTL2_uc010rtf.1_Silent_p.P335P	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	477					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		AACTGCCACCTGGCACCTGAG	0.448			NA											10	26					0	0	0.008291	0	0
CCDC81	60494	broad.mit.edu	37	11	86126174	86126174	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:86126174G>T	uc001pbx.1	+	13	1938	c.1510G>T	c.(1510-1512)GAC>TAC	p.D504Y	CCDC81_uc001pbw.1_Missense_Mutation_p.D414Y|CCDC81_uc010rtq.1_Missense_Mutation_p.D287Y|CCDC81_uc001pby.1_Missense_Mutation_p.D239Y	NM_001156474	NP_001149946	Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81 isoform 1	504										skin(1)	1		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CTTTGAGCCAGACTCCTCTGA	0.453			NA											41	27					1.06522e-23	1.65872e-23	0.003214	1	0
GRM5	2915	broad.mit.edu	37	11	88300288	88300288	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:88300288C>T	uc001pcq.2	-	7	2763	c.2563G>A	c.(2563-2565)GCA>ACA	p.A855T	GRM5_uc009yvm.2_Missense_Mutation_p.A855T	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	855	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CTGCTGGCTGCGGAGGATGAC	0.567			NA											26	64					0	0	0.005443	0	0
FOLH1B	219595	broad.mit.edu	37	11	89431656	89431656	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:89431656T>C	uc001pda.2	+	14	1744	c.1218T>C	c.(1216-1218)GAT>GAC	p.D406D		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	406					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						CTCTGTTTGATATTGAAAGCA	0.473			NA											52	29					0	0	0.00361	0	0
FAT3	120114	broad.mit.edu	37	11	92086518	92086518	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:92086518G>T	uc001pdj.3	+	1	1257	c.1240G>T	c.(1240-1242)GGT>TGT	p.G414C		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	414	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATTATCTCCTGGTGAGGATGC	0.418			NA								TCGA Ovarian(4;0.039)			7	30					8.12818e-05	8.70909e-05	0.001984	1	0
AMOTL1	154810	broad.mit.edu	37	11	94602374	94602374	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:94602374G>C	uc001pfb.2	+	12	2670	c.2500G>C	c.(2500-2502)GGG>CGG	p.G834R	AMOTL1_uc001pfc.2_Missense_Mutation_p.G784R	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	834						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				ATTGCTGCTGGGGAAGGAGCA	0.498			NA											8	23					0	0	0.008291	0	0
CNTN5	53942	broad.mit.edu	37	11	99827598	99827598	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:99827598G>T	uc001pga.2	+	8	1073	c.734G>T	c.(733-735)CGG>CTG	p.R245L	CNTN5_uc009ywv.1_Missense_Mutation_p.R245L|CNTN5_uc001pfz.2_Missense_Mutation_p.R245L|CNTN5_uc001pgb.2_Missense_Mutation_p.R171L	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	245	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GACAGCCGGCGGTTCATCTCC	0.413			NA											14	49					6.72482e-11	8.32105e-11	0.003163	1	0
PGR	5241	broad.mit.edu	37	11	100933247	100933247	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:100933247G>A	uc001pgh.2	-	4	2886	c.2143C>T	c.(2143-2145)CTG>TTG	p.L715L	PGR_uc001pgg.2_Silent_p.L96L|PGR_uc001pgi.2_Intron|PGR_uc009yww.1_Intron|PGR_uc001pgj.2_RNA|PGR_uc009ywx.1_RNA	NM_000926	NP_000917	P06401	PRGR_HUMAN	progesterone receptor	715	Steroid-binding.				cell-cell signaling|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	enzyme binding|receptor binding|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding			lung(1)|liver(1)|central_nervous_system(1)|pancreas(1)	4		Acute lymphoblastic leukemia(157;0.000885)|all_hematologic(158;0.014)		LUSC - Lung squamous cell carcinoma(1;0.0387)|BRCA - Breast invasive adenocarcinoma(274;0.124)|OV - Ovarian serous cystadenocarcinoma(223;0.148)|Lung(307;0.164)	Desogestrel(DB00304)|Drospirenone(DB01395)|Dydrogesterone(DB00378)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Mifepristone(DB00834)|Norethindrone(DB00717)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)	AGACTTGTCAGCAAAGAACTG	0.388	Pancreas(124;2271 2354 21954 22882)		NA											34	74					0	0	0.003755	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103048482	103048482	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:103048482G>T	uc001pho.2	+	38	6216	c.6072G>T	c.(6070-6072)ATG>ATT	p.M2024I	DYNC2H1_uc001phn.1_Missense_Mutation_p.M2024I|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2024	AAA 2 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		ATATTGACATGGACACAAGAG	0.393			NA											14	46					2.32078e-09	2.78437e-09	0.003163	1	0
GRIA4	2893	broad.mit.edu	37	11	105804547	105804547	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:105804547C>G	uc001pix.2	+	14	2592	c.2146C>G	c.(2146-2148)CGC>GGC	p.R716G	GRIA4_uc001piw.2_Missense_Mutation_p.R716G|GRIA4_uc010rvm.1_RNA|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	716	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AGCTCGTGTCCGCAAATCCAA	0.458			NA											7	31					0	0	0.001984	0	0
EXPH5	23086	broad.mit.edu	37	11	108382616	108382616	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:108382616T>A	uc001pkk.2	-	6	3729	c.3618A>T	c.(3616-3618)TCA>TCT	p.S1206S	EXPH5_uc010rvy.1_Silent_p.S1018S|EXPH5_uc010rvz.1_Silent_p.S1050S|EXPH5_uc010rwa.1_Silent_p.S1130S	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	1206					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		GGTCTTCATTTGAAAGAGCAA	0.388			NA											24	62					0	0	0.00278	0	0
C11orf92	399948	broad.mit.edu	37	11	111166978	111166978	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:111166978T>A	uc001pld.2	-	2	2635	c.226A>T	c.(226-228)AGC>TGC	p.S76C	C11orf92_uc001ple.2_RNA|C11orf93_uc010rwf.1_5'Flank	NM_207429	NP_997312			hypothetical protein LOC399948											lung(1)	1						CCATAAAGGCTGCTGGAGGTT	0.537			NA											17	50					0	0	0.006122	0	0
SDHD	6392	broad.mit.edu	37	11	111959687	111959687	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:111959687C>G	uc001pmz.2	+	3	327	c.266C>G	c.(265-267)TCT>TGT	p.S89C	TIMM8B_uc001pmx.2_5'Flank|TIMM8B_uc001pmy.2_5'Flank	NM_003002	NP_002993	O14521	DHSD_HUMAN	succinate dehydrogenase complex, subunit D	89	Mitochondrial intermembrane (By similarity).				respiratory electron transport chain|transport|tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain complex II	electron carrier activity|heme binding|succinate dehydrogenase activity|ubiquinone binding				0		all_cancers(61;5.7e-14)|all_epithelial(67;3.4e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.13e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;1.05e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0515)	Succinic acid(DB00139)	AATCCTTGCTCTGCGATGGAC	0.507			NA	Mis|N|F|S			paraganglioma|pheochromocytoma			Familial_Paragangliomas|Carney-Stratakis_syndrome|Cowden_syndrome				21	58					0	0	0.010504	0	0
PTS	5805	broad.mit.edu	37	11	112100953	112100953	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:112100953G>T	uc001pnj.3	+	3	265	c.186G>T	c.(184-186)GAG>GAT	p.E62D	PTS_uc009yyo.2_Intron	NM_000317	NP_000308	Q03393	PTPS_HUMAN	6-pyruvoyltetrahydropterin synthase	62					cellular amino acid metabolic process|central nervous system development|tetrahydrobiopterin biosynthetic process	mitochondrion	6-pyruvoyltetrahydropterin synthase activity|metal ion binding				0		all_cancers(61;2.51e-14)|all_epithelial(67;1.64e-08)|Melanoma(852;8.81e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.27e-06)|BRCA - Breast invasive adenocarcinoma(274;1.43e-06)|all cancers(92;2.1e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0519)		TACATGGAGAGGTATGTGCAG	0.393			NA											57	37					1.42676e-28	2.35239e-28	0.00361	1	0
USP28	57646	broad.mit.edu	37	11	113670056	113670056	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:113670056G>T	uc001poh.2	-	25	3173	c.3140C>A	c.(3139-3141)CCA>CAA	p.P1047Q	USP28_uc001pog.2_Missense_Mutation_p.P723Q|USP28_uc010rwy.1_Missense_Mutation_p.P890Q|USP28_uc001poi.2_Missense_Mutation_p.P370Q	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	1047					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCGAATTGTTGGAGGCTCTTT	0.463	Melanoma(4;162 555 7664)|GBM(79;500 2010 17506)|Esophageal Squamous(9;463 924 15765)		NA											30	87					3.80469e-20	5.61701e-20	0.009535	1	0
RNF214	257160	broad.mit.edu	37	11	117153860	117153860	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:117153860G>A	uc001pqt.2	+	14	2025	c.1980G>A	c.(1978-1980)ATG>ATA	p.M660I	RNF214_uc001pqu.2_Missense_Mutation_p.M660I|RNF214_uc010rxf.1_Missense_Mutation_p.M505I	NM_207343	NP_997226	Q8ND24	RN214_HUMAN	ring finger protein 214	660	RING-type; atypical.						zinc ion binding				0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		TATGTCTAATGTGCCAGAAAC	0.488			NA											20	52					0	0	0.00278	0	0
DSCAML1	57453	broad.mit.edu	37	11	117335788	117335788	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:117335788C>T	uc001prh.1	-	17	3317	c.3315G>A	c.(3313-3315)ACG>ACA	p.T1105T		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1045	Extracellular (Potential).|Fibronectin type-III 2.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CGCTGTCCCCCGTGGCCTTCA	0.612			NA											87	63					0	0	0.00361	0	0
DSCAML1	57453	broad.mit.edu	37	11	117667871	117667871	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:117667871C>G	uc001prh.1	-	1	106	c.104G>C	c.(103-105)CGC>CCC	p.R35P	DSCAML1_uc001pri.1_Intron	NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	Error:Variant_position_missing_in_Q8TD84_after_alignment					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCGCTCAGCGCGCTCCCAGCC	0.721			NA											6	20					0	0	0.001168	0	0
FXYD6	53826	broad.mit.edu	37	11	117710519	117710519	+	Nonstop_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:117710519A>G	uc001pro.1	-	7	352	c.286T>C	c.(286-288)TGA>CGA	p.*96R	FXYD6_uc001prn.1_Intron|FXYD6_uc001prp.1_Nonstop_Mutation_p.*96R|FXYD6_uc001prq.1_Nonstop_Mutation_p.*96R|FXYD6_uc001prr.1_Nonstop_Mutation_p.*96R|FXYD6_uc009yzq.1_3'UTR	NM_022003	NP_071286	Q9H0Q3	FXYD6_HUMAN	FXYD domain-containing ion transport regulator 6	96						integral to membrane|plasma membrane	ion channel activity			central_nervous_system(1)|skin(1)	2	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|Breast(348;0.111)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.89e-05)|Epithelial(105;0.00122)		GCTGCACTTCAGTTCTCTGCT	0.577			NA											69	67					0	0	0.00361	0	0
AMICA1	120425	broad.mit.edu	37	11	118081211	118081211	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:118081211C>A	uc001psk.2	-	4	589	c.415G>T	c.(415-417)GAG>TAG	p.E139*	AMICA1_uc001psh.2_Nonsense_Mutation_p.E100*|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Nonsense_Mutation_p.E129*|AMICA1_uc001psj.2_Nonsense_Mutation_p.E139*|AMICA1_uc010rxw.1_Nonsense_Mutation_p.E100*|AMICA1_uc010rxx.1_Nonsense_Mutation_p.E139*|AMICA1_uc001psl.1_Nonsense_Mutation_p.E95*	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	139	Ig-like V-type 2.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		CCTTTGGGCTCCTCTGGAAGC	0.507			NA											27	71					7.68411e-24	1.20041e-23	0.008361	1	0
TRIM29	23650	broad.mit.edu	37	11	120008389	120008389	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:120008389T>A	uc001pwz.2	-	1	475	c.351A>T	c.(349-351)CCA>CCT	p.P117P	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	117					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		AGGTAACGGGTGGCTTCTTGG	0.617			NA											153	166					0	0	0.00361	0	0
GRIK4	2900	broad.mit.edu	37	11	120827558	120827558	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:120827558G>T	uc001pxn.2	+	16	2057	c.1770G>T	c.(1768-1770)CAG>CAT	p.Q590H	GRIK4_uc009zav.1_Missense_Mutation_p.Q590H|GRIK4_uc009zaw.1_Missense_Mutation_p.Q590H|GRIK4_uc009zax.1_Missense_Mutation_p.Q590H	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	590	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TGGTGAACCAGTACTCCCTGG	0.622			NA											63	59					2.82337e-50	5.14646e-50	0.00361	1	0
GRIK4	2900	broad.mit.edu	37	11	120833380	120833380	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:120833380C>A	uc001pxn.2	+	18	2543	c.2256C>A	c.(2254-2256)GGC>GGA	p.G752G	GRIK4_uc009zav.1_Silent_p.G752G|GRIK4_uc009zaw.1_Silent_p.G752G|GRIK4_uc009zax.1_Silent_p.G752G	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	752	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	ATGGGATTGGCATGCCAGTCG	0.537			NA											46	50					0.000147903	0.000157775	0.00361	1	0
SC5DL	6309	broad.mit.edu	37	11	121177947	121177947	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:121177947A>G	uc001pxu.2	+	5	774	c.626A>G	c.(625-627)CAT>CGT	p.H209R	SC5DL_uc001pxt.2_3'UTR|SC5DL_uc001pxv.2_Missense_Mutation_p.H209R	NM_006918	NP_008849	O75845	SC5D_HUMAN	sterol-C5-desaturase	209					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	C-5 sterol desaturase activity|iron ion binding|lathosterol oxidase activity			ovary(1)	1		Breast(109;0.00328)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)	OV - Ovarian serous cystadenocarcinoma(1;0.0334)	BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.144)		ATTTCCATTCATGACGGTGAT	0.363			NA											86	117					0	0	0.00361	0	0
SORL1	6653	broad.mit.edu	37	11	121476192	121476192	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:121476192T>A	uc001pxx.2	+	35	4940	c.4860T>A	c.(4858-4860)GAT>GAA	p.D1620E	SORL1_uc010rzp.1_Missense_Mutation_p.D466E|SORL1_uc010rzq.1_Missense_Mutation_p.D235E	NM_003105	NP_003096	Q92673	SORL_HUMAN	sortilin-related receptor containing LDLR class	1620	Extracellular (Potential).|Fibronectin type-III 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			ovary(5)|breast(4)|large_intestine(2)|skin(2)|central_nervous_system(1)|pancreas(1)	15		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGAAACCAGATACCACGTATC	0.443			NA											50	166					0	0	0.00361	0	0
OR8D4	338662	broad.mit.edu	37	11	123777827	123777827	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:123777827C>T	uc010saa.1	+	1	689	c.689C>T	c.(688-690)TCT>TTT	p.S230F		NM_001005197	NP_001005197	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		CGCATCCACTCTAAAAAGGGC	0.433			NA											67	53					0	0	0.00361	0	0
OR8D1	283159	broad.mit.edu	37	11	124180357	124180357	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:124180357A>T	uc010sag.1	-	1	306	c.306T>A	c.(304-306)TTT>TTA	p.F102L		NM_001002917	NP_001002917	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D,	102	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CCACAAAGAAAAAGAGCTGGA	0.448			NA											15	24					0	0	0.003163	0	0
OR8D2	283160	broad.mit.edu	37	11	124189589	124189589	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:124189589A>G	uc010sah.1	-	1	505	c.505T>C	c.(505-507)TGT>CGT	p.C169R		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	169	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TGAGACCTACAGAATGACAAC	0.453			NA											29	68					0	0	0.005443	0	0
OR8B12	219858	broad.mit.edu	37	11	124413487	124413487	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:124413487G>T	uc010sam.1	-	1	64	c.64C>A	c.(64-66)CTG>ATG	p.L22M		NM_001005195	NP_001005195	Q8NGG6	OR8BC_HUMAN	olfactory receptor, family 8, subfamily B,	22	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0213)		GGGATCCGCAGTCCCGGCTGG	0.542			NA											43	38					1.15183e-24	1.81848e-24	0.009718	1	0
ROBO3	64221	broad.mit.edu	37	11	124742393	124742393	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:124742393G>A	uc001qbc.2	+	8	1467	c.1275G>A	c.(1273-1275)CAG>CAA	p.Q425Q		NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	425	Ig-like C2-type 4.|Extracellular (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		ACGTGTGCCAGGCTGTCAGTG	0.592			NA											21	28					0	0	0.010504	0	0
ACRV1	56	broad.mit.edu	37	11	125547943	125547943	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:125547943G>T	uc001qcs.2	-	2	569	c.302C>A	c.(301-303)ACT>AAT	p.T101N	ACRV1_uc001qck.2_Intron|ACRV1_uc001qcl.2_Intron|ACRV1_uc001qcm.2_Intron|ACRV1_uc001qcn.2_Missense_Mutation_p.T46N|ACRV1_uc001qco.2_Intron|ACRV1_uc001qcp.2_Intron|ACRV1_uc001qcq.2_Intron|ACRV1_uc001qcr.2_Missense_Mutation_p.T101N	NM_001612	NP_001603	P26436	ASPX_HUMAN	acrosomal vesicle protein 1 isoform a precursor	101	4 X 4 AA repeats of S-G-E-H.				multicellular organismal development	acrosomal vesicle					0	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0179)|Lung NSC(97;0.0185)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0713)		AGCATGTTCAGTCGCAGCGGG	0.542			NA											38	120					9.8876e-21	1.47893e-20	0.004878	1	0
ARHGAP32	9743	broad.mit.edu	37	11	128839000	128839000	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:128839000C>A	uc009zcp.2	-	22	6066	c.6066G>T	c.(6064-6066)CAG>CAT	p.Q2022H	ARHGAP32_uc009zcq.1_3'UTR|ARHGAP32_uc009zco.2_Missense_Mutation_p.Q981H|ARHGAP32_uc001qez.2_Missense_Mutation_p.Q1673H	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	2022	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						GGTTATCATACTGGGACACAA	0.577			NA											31	57					1.08312e-15	1.4731e-15	0.009535	1	0
APLP2	334	broad.mit.edu	37	11	130011868	130011868	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:130011868G>T	uc010sby.1	+	17	2246	c.2089G>T	c.(2089-2091)GGC>TGC	p.G697C	APLP2_uc001qfp.2_Missense_Mutation_p.G685C|APLP2_uc001qfq.2_Missense_Mutation_p.G629C|APLP2_uc010sbz.1_Missense_Mutation_p.G485C|APLP2_uc001qfr.2_Missense_Mutation_p.G451C|APLP2_uc001qfs.2_Missense_Mutation_p.G456C|APLP2_uc001qfv.2_Missense_Mutation_p.G588C|APLP2_uc009zcv.2_Missense_Mutation_p.G45C	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	697	Helical; (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TGCTCTCATTGGCCTGCTGGT	0.562			NA											28	46					4.87955e-14	6.38502e-14	0.005443	1	0
GLB1L3	112937	broad.mit.edu	37	11	134182308	134182308	+	Silent	SNP	C	C	A	rs75421740		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:134182308C>A	uc009zdf.2	+	14	1713	c.1353C>A	c.(1351-1353)TCC>TCA	p.S451S	GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	451					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GCGGCCAGTCCTACGGGCTTG	0.592			NA											34	40					6.00712e-18	8.55506e-18	0.002445	1	0
KDM5A	5927	broad.mit.edu	37	12	419077	419077	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:419077C>T	uc001qif.1	-	22	3633	c.3270G>A	c.(3268-3270)AGG>AGA	p.R1090R	KDM5A_uc001qie.1_Silent_p.R1090R|KDM5A_uc010sdn.1_Silent_p.R1049R	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1090					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TTACTTTTTTCCTCCTATTTT	0.403			NA	T 	NUP98	AML								37	7					0	0	0.004878	0	0
ERC1	23085	broad.mit.edu	37	12	1291232	1291232	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:1291232G>T	uc001qjb.2	+	10	2257	c.2016_splice	c.e10+1	p.E672_splice	ERC1_uc001qiz.2_Splice_Site|ERC1_uc001qjc.2_Splice_Site_p.E644_splice|ERC1_uc001qja.2_Splice_Site|ERC1_uc001qjd.2_Splice_Site|ERC1_uc001qjf.2_Splice_Site_p.E672_splice|ERC1_uc010sdv.1_Splice_Site_p.E420_splice|ERC1_uc009zdp.2_Splice_Site_p.E312_splice	NM_178040	NP_829884	Q8IUD2	RB6I2_HUMAN	RAB6-interacting protein 2 isoform epsilon						I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			ovary(2)|lung(2)|breast(1)	5	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			AGAGAAAGAGGTTAAGCTCCC	0.358			NA											12	3					2.80697e-09	3.35311e-09	0.000978	1	0
KCNA5	3741	broad.mit.edu	37	12	5153658	5153658	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:5153658G>T	uc001qni.2	+	1	574	c.345G>T	c.(343-345)GCG>GCT	p.A115A		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	115						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						TGGGCACGGCGTCCCTGCACC	0.697			NA											12	5					5.16669e-11	6.41359e-11	0.000978	1	0
VWF	7450	broad.mit.edu	37	12	6121286	6121286	+	Silent	SNP	C	C	T	rs144221902		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:6121286C>T	uc001qnn.1	-	33	5881	c.5631G>A	c.(5629-5631)AGG>AGA	p.R1877R	VWF_uc010set.1_Intron	NM_000552	NP_000543	P04275	VWF_HUMAN	von Willebrand factor preproprotein	1877					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)	12					Antihemophilic Factor(DB00025)	CCATGCAAATCCTAACAAATC	0.428			NA											103	28					0	0	0.00361	0	0
GPR162	27239	broad.mit.edu	37	12	6936231	6936231	+	Silent	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:6936231T>G	uc001qqw.1	+	5	2164	c.1629T>G	c.(1627-1629)CCT>CCG	p.P543P	LEPREL2_uc001qqz.1_5'Flank|LEPREL2_uc001qra.1_5'Flank|LEPREL2_uc001qrb.1_5'Flank|GPR162_uc001qqx.1_Silent_p.P259P|GPR162_uc009zfd.1_Silent_p.P239P|GPR162_uc001qqy.1_Intron	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	543	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TTGGGTCCCCTGAGAGCAGAG	0.652			NA											71	16					0	0	0.00361	0	0
USP5	8078	broad.mit.edu	37	12	6965198	6965198	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:6965198G>T	uc001qri.3	+	4	381	c.322G>T	c.(322-324)GAC>TAC	p.D108Y	USP5_uc001qrh.3_Missense_Mutation_p.D108Y	NM_001098536	NP_001092006	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 isoform 1	108					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			lung(2)|breast(1)|skin(1)	4						AGGCGGATTTGACCTTAGCGA	0.522			NA											118	29					1.14919e-56	2.11671e-56	0.00361	1	0
GUCY2C	2984	broad.mit.edu	37	12	14809552	14809552	+	Splice_Site	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:14809552C>G	uc001rcd.2	-	12	1502	c.1365_splice	c.e12-1	p.R455_splice		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor						intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TCTATATTTTCTGTGAAAGGA	0.373			NA											35	6					0	0	0.002836	0	0
RERG	85004	broad.mit.edu	37	12	15370383	15370383	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:15370383C>A	uc001rcs.2	-	1	181	c.41G>T	c.(40-42)AGA>ATA	p.R14I	RERG_uc001rct.2_Missense_Mutation_p.R14I|RERG_uc010shu.1_Missense_Mutation_p.R14I	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	14	GTP.				negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CACGCCTGCTCTCCCAAATAT	0.418			NA											60	16					2.165e-29	3.58179e-29	0.00361	1	0
EPS8	2059	broad.mit.edu	37	12	15777257	15777257	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:15777257T>C	uc009zif.2	-	19	2223	c.2129A>G	c.(2128-2130)CAT>CGT	p.H710R	EPS8_uc001rdb.2_Missense_Mutation_p.H710R|EPS8_uc009zig.2_Missense_Mutation_p.H450R|EPS8_uc010shv.1_Missense_Mutation_p.H450R	NM_004447	NP_004438	Q12929	EPS8_HUMAN	epidermal growth factor receptor pathway	710					cell proliferation|epidermal growth factor receptor signaling pathway		SH3/SH2 adaptor activity			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4		all_epithelial(100;1.87e-05)|Breast(259;0.000286)|Hepatocellular(102;0.244)		BRCA - Breast invasive adenocarcinoma(232;4.29e-05)|GBM - Glioblastoma multiforme(207;0.0264)		CCGTGGCACATGGAATTTCTT	0.493			NA											71	22					0	0	0.00361	0	0
PDE3A	5139	broad.mit.edu	37	12	20769266	20769266	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:20769266G>T	uc001reh.1	+	4	1394	c.1372G>T	c.(1372-1374)GTA>TTA	p.V458L		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	458					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GCCTGCACCAGTACGGAGAGA	0.547			NA											44	43					1.63429e-32	2.77256e-32	0.00361	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21051426	21051426	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:21051426G>A	uc001rek.2	+	13	1865	c.1739G>A	c.(1738-1740)AGA>AAA	p.R580K	SLCO1B3_uc001rel.2_Missense_Mutation_p.R580K|SLCO1B3_uc010sil.1_Missense_Mutation_p.R580K|LST-3TM12_uc010sim.1_Intron|SLCO1B3_uc001reo.2_Missense_Mutation_p.R405K	NM_019844	NP_062818	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family,	580	Helical; Name=11; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					ATGGTTATAAGAACACTAGGT	0.259			NA											14	20					0	0	0.004007	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21229434	21229434	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:21229434G>T	uc010sil.1	+	15	2044	c.1979G>T	c.(1978-1980)TGT>TTT	p.C660F	LST-3TM12_uc010sim.1_Missense_Mutation_p.C599F|LST-3TM12_uc010sin.1_Missense_Mutation_p.C552F			Q9NPD5	SO1B3_HUMAN	SubName: Full=Liver-specific organic anion transporter 3TM13; SubName: Full=Organic anion transporter LST-3c;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			large_intestine(2)|ovary(1)|skin(1)	4	Esophageal squamous(101;0.149)					GATACAACGTGTATGAAGTGG	0.353			NA											85	63					1.37401e-58	2.5429e-58	0.00361	1	0
SSPN	8082	broad.mit.edu	37	12	26383870	26383870	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:26383870A>T	uc001rhe.2	+	3	693	c.593A>T	c.(592-594)CAG>CTG	p.Q198L	SSPN_uc001rhd.2_Missense_Mutation_p.Q95L|SSPN_uc009zjf.2_Intron|SSPN_uc001rhf.3_Intron	NM_005086	NP_005077	Q14714	SSPN_HUMAN	sarcospan isoform 1	198	Helical; (Potential).				cell adhesion|muscle contraction	cell junction|dystrophin-associated glycoprotein complex|integral to plasma membrane|postsynaptic membrane|sarcolemma|transport vesicle					0	Colorectal(261;0.0847)					TTACTCATCCAGATGATTCTT	0.502			NA											38	95					0	0	0.007835	0	0
MRPS35	60488	broad.mit.edu	37	12	27908112	27908112	+	Splice_Site	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:27908112A>G	uc001rih.2	+	8	751	c.703_splice	c.e8-2	p.N235_splice	MRPS35_uc001rii.2_Splice_Site	NM_021821	NP_068593	P82673	RT35_HUMAN	mitochondrial ribosomal protein S35 precursor						DNA damage response, detection of DNA damage	mitochondrial small ribosomal subunit					0	Lung SC(9;0.0873)					GTTTTGTTTCAGAATACTGAA	0.249			NA											12	60					0	0	0.001368	0	0
TMTC1	83857	broad.mit.edu	37	12	29670436	29670436	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:29670436C>A	uc001rjb.2	-	14	2243	c.1769G>T	c.(1768-1770)CGA>CTA	p.R590L	TMTC1_uc001riz.2_Missense_Mutation_p.R347L|TMTC1_uc001rja.2_Missense_Mutation_p.R434L|TMTC1_uc001riy.2_Missense_Mutation_p.R43L	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	698	TPR 7.					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CTCTTCGTATCGGCCAGTGTT	0.478			NA											38	105					2.68985e-26	4.32433e-26	0.00361	1	0
TMTC1	83857	broad.mit.edu	37	12	29904703	29904704	+	Missense_Mutation	DNP	CC	CC	AG	rs146096763	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:29904703_29904704CC>AG	uc001rjb.2	-	5	983_984	c.509_510GG>CT	c.(508-510)CGG>CCT	p.R170P	TMTC1_uc001rjc.1_Missense_Mutation_p.R170P	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	278						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TGTGAGGGAACCGCTGCTGCTT	0.569			NA											12	31					0	0	0.004672	0	0
PKP2	5318	broad.mit.edu	37	12	33003763	33003763	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:33003763C>T	uc001rlj.3	-	5	1430	c.1315G>A	c.(1315-1317)GTA>ATA	p.V439I	PKP2_uc001rlk.3_Missense_Mutation_p.V439I|PKP2_uc010skj.1_Missense_Mutation_p.V439I	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	439	ARM 3.				cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AGCCGAGGTACCCCATTTAGT	0.433			NA											63	39					0	0	0.00361	0	0
SYT10	341359	broad.mit.edu	37	12	33559808	33559808	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:33559808C>A	uc001rll.1	-	3	1290	c.993G>T	c.(991-993)GGG>GGT	p.G331G	SYT10_uc009zju.1_Silent_p.G141G	NM_198992	NP_945343	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	331	Cytoplasmic (Potential).|C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			ovary(1)|skin(1)	2	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GAATCACTTCCCCAATCATGT	0.363			NA											23	25					2.98393e-07	3.40668e-07	0.00278	1	0
PRICKLE1	144165	broad.mit.edu	37	12	42853934	42853934	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:42853934T>C	uc010skv.1	-	8	2460	c.2173A>G	c.(2173-2175)ATC>GTC	p.I725V	PRICKLE1_uc001rnl.2_Missense_Mutation_p.I725V|PRICKLE1_uc010skw.1_Missense_Mutation_p.I725V|PRICKLE1_uc001rnm.2_Missense_Mutation_p.I725V|PRICKLE1_uc001rnk.1_5'Flank	NM_001144881	NP_001138353	Q96MT3	PRIC1_HUMAN	prickle homolog 1	725					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			ovary(3)|skin(1)	4	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GCATTCTGGATGTATGCTTGG	0.488			NA											28	46					0	0	0.008361	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43771274	43771274	+	Missense_Mutation	SNP	C	C	G	rs112430320		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:43771274C>G	uc010skx.1	-	32	4889	c.4889G>C	c.(4888-4890)CGG>CCG	p.R1630P		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1630	TSP type-1 14.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AACTATAGGCCGAAGTCGATG	0.413			NA											19	9					0	0	0.010504	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43822270	43822270	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:43822270G>T	uc010skx.1	-	26	3719	c.3719C>A	c.(3718-3720)CCA>CAA	p.P1240Q	ADAMTS20_uc001rno.1_Missense_Mutation_p.P358Q|ADAMTS20_uc001rnp.1_Missense_Mutation_p.P394Q	NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	1240	TSP type-1 8.					proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTCATCAATTGGCTGATGGTA	0.443			NA											19	5					8.28177e-16	1.13194e-15	0.007413	1	0
NELL2	4753	broad.mit.edu	37	12	45173785	45173785	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:45173785C>A	uc001rog.2	-	4	951	c.356G>T	c.(355-357)AGT>ATT	p.S119I	NELL2_uc001rof.3_Missense_Mutation_p.S118I|NELL2_uc001roh.2_Missense_Mutation_p.S119I|NELL2_uc009zkd.2_Missense_Mutation_p.S118I|NELL2_uc010skz.1_Missense_Mutation_p.S169I|NELL2_uc010sla.1_Missense_Mutation_p.S142I|NELL2_uc001roi.1_Missense_Mutation_p.S119I|NELL2_uc010slb.1_Missense_Mutation_p.S118I|NELL2_uc001roj.2_Missense_Mutation_p.S119I	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	119	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CCGATGGCCACTACTTTCCAG	0.413			NA											46	18					2.77807e-22	4.24726e-22	0.003214	1	0
NELL2	4753	broad.mit.edu	37	12	45269639	45269639	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:45269639A>T	uc001rog.2	-	1	609	c.14T>A	c.(13-15)GTC>GAC	p.V5D	NELL2_uc001rof.3_5'Flank|NELL2_uc001roh.2_Missense_Mutation_p.V5D|NELL2_uc009zkd.2_5'UTR|NELL2_uc010skz.1_Missense_Mutation_p.V55D|NELL2_uc010sla.1_Missense_Mutation_p.V28D|NELL2_uc001roi.1_Missense_Mutation_p.V5D|NELL2_uc010slb.1_5'UTR|NELL2_uc001roj.2_Missense_Mutation_p.V5D	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	5					cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TCTCAGTAAGACCCGAGACTC	0.517			NA											49	24					0	0	0.00361	0	0
FAM113B	91523	broad.mit.edu	37	12	47630123	47630123	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:47630123A>G	uc001rpn.2	+	4	2008	c.1277A>G	c.(1276-1278)AAT>AGT	p.N426S	FAM113B_uc001rpq.2_Missense_Mutation_p.N426S	NM_138371	NP_612380	Q96HM7	F113B_HUMAN	hypothetical protein LOC91523	426	Pro-rich.						hydrolase activity			skin(3)|ovary(2)	5	Renal(347;0.138)|Lung SC(27;0.192)					GCCCCAGCCAATCCTGAGCCA	0.552			NA											8	3					0	0	0.004482	0	0
COL2A1	1280	broad.mit.edu	37	12	48386700	48386700	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:48386700C>A	uc001rqu.2	-	16	1165	c.984G>T	c.(982-984)CTG>CTT	p.L328L	COL2A1_uc001rqv.2_Silent_p.L259L	NM_001844	NP_001835	P02458	CO2A1_HUMAN	collagen, type II, alpha 1 isoform 1 precursor	328	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TTTCACCAGGCAGGCCACGAG	0.483			NA											8	18					1.06961e-07	1.23722e-07	0.00308	1	0
WNT10B	7480	broad.mit.edu	37	12	49361986	49361986	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:49361986C>G	uc001rss.2	-	4	800	c.454G>C	c.(454-456)GGT>CGT	p.G152R	WNT10B_uc001rst.2_Missense_Mutation_p.G152R	NM_003394	NP_003385	O00744	WN10B_HUMAN	wingless-type MMTV integration site family,	152					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			skin(4)|lung(3)	7						TCCTGCTCACCACTGCCCTTC	0.552			NA											36	10					0	0	0.005524	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50189365	50189365	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:50189365G>A	uc009zlk.2	-	8	2480	c.2278C>T	c.(2278-2280)CGG>TGG	p.R760W	NCKAP5L_uc001rvc.3_5'UTR|NCKAP5L_uc001rvb.2_Missense_Mutation_p.R353W	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	756										central_nervous_system(1)	1						AGGTCCACCCGGGCCCCCATG	0.667			NA											12	1					0	0	0.001368	0	0
AQP2	359	broad.mit.edu	37	12	50344880	50344880	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:50344880C>A	uc001rvn.2	+	1	357	c.267C>A	c.(265-267)TAC>TAA	p.Y89*		NM_000486	NP_000477	P41181	AQP2_HUMAN	aquaporin 2	89	Helical; (Potential).				cellular response to copper ion|cellular response to mercury ion|excretion	apical plasma membrane|integral to membrane|transport vesicle membrane	glycerol transmembrane transporter activity|water channel activity			ovary(2)	2						CCGCCTTCTACGTGGCTGCCC	0.657			NA											22	5					1.87028e-06	2.0836e-06	0.001882	1	0
LARP4	113251	broad.mit.edu	37	12	50822840	50822840	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:50822840G>T	uc001rwp.1	+	3	433	c.289G>T	c.(289-291)GAA>TAA	p.E97*	LARP4_uc001rwo.1_Nonsense_Mutation_p.E103*|LARP4_uc001rwq.1_Nonsense_Mutation_p.E97*|LARP4_uc001rwr.1_Nonsense_Mutation_p.E97*|LARP4_uc001rws.1_Nonsense_Mutation_p.E96*|LARP4_uc001rwm.2_Nonsense_Mutation_p.E97*|LARP4_uc001rwn.2_Nonsense_Mutation_p.E27*	NM_052879	NP_443111	Q71RC2	LARP4_HUMAN	c-Mpl binding protein isoform a	97							nucleotide binding|RNA binding			ovary(1)	1						TTTAGGACCAGAAGATCTGAG	0.348			NA											27	6					1.30988e-24	2.06632e-24	0.002096	1	0
SCN8A	6334	broad.mit.edu	37	12	52200380	52200380	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:52200380T>A	uc001ryw.2	+	27	5288	c.5110T>A	c.(5110-5112)TCA>ACA	p.S1704T		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1704	IV.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AATCACAACCTCAGCTGGTTG	0.507			NA											47	11					0	0	0.00361	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284445	52284445	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:52284445A>C	uc001rzf.3	+	5	919	c.340A>C	c.(340-342)ACC>CCC	p.T114P	ANKRD33_uc001rzh.3_3'UTR|ANKRD33_uc001rzd.2_Missense_Mutation_p.T239P|ANKRD33_uc001rze.2_Missense_Mutation_p.T135P|ANKRD33_uc001rzg.3_Missense_Mutation_p.T41P|ANKRD33_uc001rzi.3_Missense_Mutation_p.T114P	NM_001130015	NP_001123487	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33 isoform 1	114	ANK 3.										0				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CAGCTTCGACACCGTGTGGAG	0.632			NA											8	22					0	0	0.006214	0	0
ACVR1B	91	broad.mit.edu	37	12	52385742	52385742	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:52385742C>G	uc001rzn.2	+	8	1399	c.1357C>G	c.(1357-1359)CGT>GGT	p.R453G	ACVR1B_uc001rzm.2_Missense_Mutation_p.R453G|ACVR1B_uc010snn.1_Missense_Mutation_p.R494G	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	453	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	TCAGAAGCTGCGTCCCAACAT	0.498			NA											54	12					0	0	0.00361	0	0
SP1	6667	broad.mit.edu	37	12	53777109	53777109	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:53777109G>T	uc001scw.2	+	3	1475	c.1378G>T	c.(1378-1380)GGA>TGA	p.G460*	SP1_uc010sog.1_Nonsense_Mutation_p.G453*	NM_138473	NP_612482	P08047	SP1_HUMAN	Sp1 transcription factor isoform a	460	Transactivation domain B (Gln-rich).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|breast(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(357;0.00527)		GGGGCCCAATGGACAGGTCAG	0.542			NA											26	64					7.26314e-15	9.69421e-15	0.007291	1	0
RDH5	5959	broad.mit.edu	37	12	56117674	56117674	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:56117674G>A	uc001shk.2	+	4	757	c.574G>A	c.(574-576)GAT>AAT	p.D192N	RDH5_uc001shl.2_Missense_Mutation_p.D192N	NM_002905	NP_002896	Q92781	RDH1_HUMAN	retinol dehydrogenase 5 (11-cis and 9-cis)	192					response to stimulus|visual perception	membrane	binding|retinol dehydrogenase activity			ovary(1)	1					NADH(DB00157)|Vitamin A(DB00162)	CTCTAGGCGGGATGTAGCTCA	0.567			NA											35	9					0	0	0.004289	0	0
SILV	6490	broad.mit.edu	37	12	56348026	56348026	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:56348026C>T	uc001sip.2	-	11	1989	c.1958G>A	c.(1957-1959)AGC>AAC	p.S653N	SILV_uc001siq.2_Missense_Mutation_p.S660N|SILV_uc010spx.1_Missense_Mutation_p.S567N|SILV_uc001sir.2_Missense_Mutation_p.S653N	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	653	Cytoplasmic (Potential).				melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GAGGAGGGGGCTGTTCTCACC	0.527			NA											38	6					0	0	0.004878	0	0
PPM1H	57460	broad.mit.edu	37	12	63225978	63225978	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:63225978G>T	uc001srk.3	-	2	476	c.327C>A	c.(325-327)GCC>GCA	p.A109A		NM_020700	NP_065751	Q9ULR3	PPM1H_HUMAN	protein phosphatase 1H (PP2C domain containing)	109							phosphoprotein phosphatase activity			lung(3)|ovary(1)	4			GBM - Glioblastoma multiforme(1;0.000443)|BRCA - Breast invasive adenocarcinoma(9;0.209)	GBM - Glioblastoma multiforme(28;0.0126)		TTGAGGTCACGGCCCCTGCCT	0.552			NA											14	16					2.61681e-11	3.26933e-11	0.00245	1	0
AVPR1A	552	broad.mit.edu	37	12	63544072	63544072	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:63544072C>T	uc001sro.1	-	1	2519	c.545G>A	c.(544-546)AGC>AAC	p.S182N		NM_000706	NP_000697	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	182	Helical; Name=4; (Potential).				activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity				0			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CTGCGGCGTGCTCAGCACGAA	0.652			NA											57	6					0	0	0.00361	0	0
DPY19L2	283417	broad.mit.edu	37	12	63954414	63954414	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:63954414C>A	uc001srp.1	-	22	2336	c.2155G>T	c.(2155-2157)GAT>TAT	p.D719Y	DPY19L2_uc010sso.1_Missense_Mutation_p.D166Y	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	719					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TCTTCCACATCCCAGATTTCA	0.423			NA											16	3					0.00074312	0.000778124	0.006122	1	0
MDM1	56890	broad.mit.edu	37	12	68710012	68710012	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:68710012C>G	uc001stz.2	-	8	1163	c.1027G>C	c.(1027-1029)GCT>CCT	p.A343P	MDM1_uc010stc.1_Missense_Mutation_p.A308P|MDM1_uc009zqv.1_Missense_Mutation_p.A63P	NM_017440	NP_059136	Q8TC05	MDM1_HUMAN	mouse Mdm1 nuclear protein homolog isoform 1	343						nucleus				ovary(3)|skin(2)	5			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		TAAAACTCAGCCTTTTCTCGG	0.403			NA											16	2					0	0	0.004007	0	0
KCNC2	3747	broad.mit.edu	37	12	75444566	75444566	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:75444566C>A	uc001sxg.1	-	3	1763	c.1219G>T	c.(1219-1221)GGA>TGA	p.G407*	KCNC2_uc009zry.2_Nonsense_Mutation_p.G407*|KCNC2_uc001sxe.2_Nonsense_Mutation_p.G407*|KCNC2_uc001sxf.2_Nonsense_Mutation_p.G407*|KCNC2_uc010stw.1_Nonsense_Mutation_p.G407*	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	407					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						GGTTGAGCTCCCACTCTCTCG	0.448			NA											27	6					6.04164e-23	9.30298e-23	0.002096	1	0
KCNC2	3747	broad.mit.edu	37	12	75601353	75601353	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:75601353C>A	uc001sxg.1	-	2	955	c.411G>T	c.(409-411)GAG>GAT	p.E137D	KCNC2_uc009zry.2_Missense_Mutation_p.E137D|KCNC2_uc001sxe.2_Missense_Mutation_p.E137D|KCNC2_uc001sxf.2_Missense_Mutation_p.E137D|KCNC2_uc010stw.1_Missense_Mutation_p.E137D	NM_139137	NP_631875	Q96PR1	KCNC2_HUMAN	Shaw-related voltage-gated potassium channel	137	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(2)|pancreas(2)|skin(1)|lung(1)	6						AGAAGGCCAGCTCCTCCTCGA	0.667			NA											41	13					1.41504e-22	2.16852e-22	0.002852	1	0
NAV3	89795	broad.mit.edu	37	12	78362454	78362454	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:78362454G>T	uc001syp.2	+	5	816	c.643G>T	c.(643-645)GCC>TCC	p.A215S	NAV3_uc001syo.2_Missense_Mutation_p.A215S	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	215						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGCCAGCCAGGCCAAAACCCA	0.443			NA								HNSCC(70;0.22)			15	0					1.5739e-10	1.93387e-10	0.004007	1	0
C12orf26	84190	broad.mit.edu	37	12	82871108	82871108	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:82871108C>T	uc001szq.2	+	11	1717	c.1696C>T	c.(1696-1698)CGA>TGA	p.R566*		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	566											0						TCTTCTGGATCGACTTTGTTA	0.294			NA											21	42					0	0	0.002299	0	0
C12orf50	160419	broad.mit.edu	37	12	88391905	88391905	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:88391905G>A	uc001tam.1	-	4	364	c.196C>T	c.(196-198)CTG>TTG	p.L66L	C12orf50_uc001tan.2_Silent_p.L120L	NM_152589	NP_689802	Q8NA57	CL050_HUMAN	hypothetical protein LOC160419	66										skin(2)|ovary(1)	3						TGAGGTTTCAGAGGTTCTTGA	0.373			NA											22	6					0	0	0.00278	0	0
C12orf12	196477	broad.mit.edu	37	12	91348364	91348364	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:91348364G>T	uc001tbj.2	-	1	590	c.156C>A	c.(154-156)CAC>CAA	p.H52Q		NM_152638	NP_689851	Q8TC90	CL012_HUMAN	hypothetical protein LOC196477	52										central_nervous_system(1)|pancreas(1)	2						GGCTATATCGGTGCGGTCTAT	0.567			NA											9	17					1.12685e-05	1.23405e-05	0.004482	1	0
NR2C1	7181	broad.mit.edu	37	12	95451334	95451334	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:95451334C>G	uc001tdm.3	-	7	1034	c.778G>C	c.(778-780)GAT>CAT	p.D260H	NR2C1_uc010suu.1_Missense_Mutation_p.D260H|NR2C1_uc001tdo.3_Missense_Mutation_p.D260H|NR2C1_uc001tdn.3_Missense_Mutation_p.D260H	NM_003297	NP_003288	P13056	NR2C1_HUMAN	nuclear receptor subfamily 2, group C, member 1	260					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	PML body	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)	1						CACACCTTATCTGATGTCATC	0.328			NA											23	5					0	0	0.001882	0	0
ANO4	121601	broad.mit.edu	37	12	101295615	101295615	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:101295615C>A	uc010svm.1	+	2	624	c.52C>A	c.(52-54)CCA>ACA	p.P18T	ANO4_uc010svl.1_RNA|ANO4_uc001thw.2_Missense_Mutation_p.P18T|ANO4_uc001thx.2_Missense_Mutation_p.P18T	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	18	Extracellular (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						AGTCTTCCACCCAGGTGATGC	0.458			NA								HNSCC(74;0.22)			33	47					4.3181e-19	6.26967e-19	0.002836	1	0
ANO4	121601	broad.mit.edu	37	12	101480565	101480565	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:101480565T>A	uc010svm.1	+	17	2236	c.1664T>A	c.(1663-1665)GTG>GAG	p.V555E	ANO4_uc001thw.2_Missense_Mutation_p.V520E|ANO4_uc001thx.2_Missense_Mutation_p.V555E|ANO4_uc001thy.2_Missense_Mutation_p.V75E	NM_178826	NP_849148	Q32M45	ANO4_HUMAN	anoctamin 4	555	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(4)|skin(2)	6						GGGACTGCTGTGTGCATCAAC	0.483			NA								HNSCC(74;0.22)			51	9					0	0	0.00361	0	0
MYBPC1	4604	broad.mit.edu	37	12	102023252	102023252	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:102023252C>A	uc001tii.2	+	4	246	c.144C>A	c.(142-144)GCC>GCA	p.A48A	MYBPC1_uc001tif.1_Silent_p.A61A|MYBPC1_uc001tig.2_Silent_p.A73A|MYBPC1_uc010svq.1_Silent_p.A35A|MYBPC1_uc001tih.2_Silent_p.A73A|MYBPC1_uc001tij.2_Silent_p.A48A|MYBPC1_uc010svr.1_Silent_p.A48A|MYBPC1_uc010svs.1_Silent_p.A48A|MYBPC1_uc010svt.1_Silent_p.A36A|MYBPC1_uc010svu.1_Silent_p.A48A|MYBPC1_uc001tik.2_Silent_p.A22A	NM_206820	NP_996556	Q00872	MYPC1_HUMAN	myosin binding protein C, slow type isoform 3	48					cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			ovary(2)|liver(1)|skin(1)	4						AGGAACAAGCCAAGCAGAATG	0.478			NA											23	5					7.92952e-12	9.99719e-12	0.003954	1	0
STAB2	55576	broad.mit.edu	37	12	104129323	104129323	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:104129323G>T	uc001tjw.2	+	52	5701	c.5515G>T	c.(5515-5517)GAG>TAG	p.E1839*	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1839	Extracellular (Potential).|FAS1 6.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GCAAGGTTCAGAGCTGAGTGT	0.532			NA											12	5					1.61879e-10	1.98651e-10	0.001368	1	0
RFX4	5992	broad.mit.edu	37	12	107090223	107090223	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:107090223A>T	uc001tlr.2	+	8	898	c.832A>T	c.(832-834)AGC>TGC	p.S278C	RFX4_uc010swv.1_RNA|RFX4_uc001tls.2_Missense_Mutation_p.S287C|RFX4_uc001tlt.2_Missense_Mutation_p.S287C|RFX4_uc001tlv.2_Missense_Mutation_p.S184C	NM_213594	NP_998759	Q33E94	RFX4_HUMAN	regulatory factor X4 isoform c	278					transcription, DNA-dependent	nucleus	DNA binding			upper_aerodigestive_tract(1)	1						ATTACCTGACAGGTGGGCATG	0.522			NA											39	6					0	0	0.00623	0	0
ACACB	32	broad.mit.edu	37	12	109577742	109577742	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:109577742G>T	uc001tob.2	+	2	651	c.532G>T	c.(532-534)GAC>TAC	p.D178Y	ACACB_uc001toc.2_Missense_Mutation_p.D178Y	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	178					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	CTCCGACGAGGACTCTGTTGC	0.572			NA											58	20					1.06179e-41	1.88914e-41	0.00361	1	0
MMAB	326625	broad.mit.edu	37	12	109999611	109999611	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:109999611C>G	uc001tou.2	-	5	468	c.395G>C	c.(394-396)TGC>TCC	p.C132S	MMAB_uc001tov.2_RNA|MMAB_uc001tow.2_RNA|MMAB_uc010sxq.1_Missense_Mutation_p.C41S|MMAB_uc001tox.2_Missense_Mutation_p.C80S	NM_052845	NP_443077	Q96EY8	MMAB_HUMAN	cob(I)alamin adenosyltransferase precursor	132					cobalamin biosynthetic process	mitochondrion	ATP binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity				0					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GGCCGAGGAGCATGGTGTCGC	0.582			NA											3	1					0	0	0.004672	0	0
TBX5	6910	broad.mit.edu	37	12	114823344	114823344	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:114823344G>T	uc001tvo.2	-	7	1187	c.692C>A	c.(691-693)CCC>CAC	p.P231H	TBX5_uc001tvp.2_Missense_Mutation_p.P231H|TBX5_uc001tvq.2_Missense_Mutation_p.P181H|TBX5_uc010syv.1_Missense_Mutation_p.P231H	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	231	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TTTGGCAAAGGGATTATTCTC	0.453	NSCLC(152;1358 1980 4050 23898 40356)		NA											32	13					4.39465e-27	7.12426e-27	0.002836	1	0
TMEM120B	144404	broad.mit.edu	37	12	122188331	122188331	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:122188331C>T	uc001ubc.3	+	4	495	c.351C>T	c.(349-351)CTC>CTT	p.L117L	TMEM120B_uc009zxh.2_Silent_p.L117L	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	117	Helical; (Potential).					integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		TGACCCTCCTCAGCAACCAGG	0.333			NA											45	6					0	0	0.002522	0	0
WDR66	144406	broad.mit.edu	37	12	122413223	122413223	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:122413223G>A	uc009zxk.2	+	18	2987	c.2845G>A	c.(2845-2847)GAA>AAA	p.E949K		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	949							calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		TGGTGGCCGGGAAGGAAAATT	0.463	Esophageal Squamous(85;849 1794 49757 52143)		NA											21	21					0	0	0.002299	0	0
FZD10	11211	broad.mit.edu	37	12	130647776	130647776	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:130647776G>C	uc001uii.2	+	1	745	c.289G>C	c.(289-291)GAG>CAG	p.E97Q	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	97	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GATGTGCACCGAGCAGGTCTC	0.652			NA											32	44					0	0	0.002096	0	0
SFRS8	6433	broad.mit.edu	37	12	132195869	132195869	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr12:132195869G>A	uc001uja.1	+	1	235	c.95G>A	c.(94-96)CGA>CAA	p.R32Q	SFRS8_uc010tbn.1_Missense_Mutation_p.R32Q|SFRS8_uc001ujb.1_5'UTR|SFRS8_uc001uiz.1_5'UTR	NM_004592	NP_004583	Q12872	SFSWA_HUMAN	splicing factor, arginine/serine-rich 8	32					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.44e-07)|Epithelial(86;2.94e-06)|all cancers(50;4.82e-05)		GGGGGCAGCCGAGTGGAGCTC	0.697			NA											17	35					0	0	0.00499	0	0
TPTE2	93492	broad.mit.edu	37	13	20038657	20038657	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:20038657C>A	uc001umd.2	-	11	891	c.680G>T	c.(679-681)CGT>CTT	p.R227L	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.R116L|TPTE2_uc001ume.2_Missense_Mutation_p.R150L|TPTE2_uc009zzm.2_5'UTR|TPTE2_uc010tcm.1_RNA	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	227	Phosphatase tensin-type.					endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		AGCAATAATACGTTCTGAAAG	0.299			NA											18	9					8.00594e-06	8.79744e-06	0.007413	1	0
GJA3	2700	broad.mit.edu	37	13	20716932	20716932	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:20716932C>A	uc001umx.1	-	2	668	c.496G>T	c.(496-498)GGC>TGC	p.G166C		NM_021954	NP_068773	Q9Y6H8	CXA3_HUMAN	connexin 46	166	Helical; (Potential).				cell-cell signaling|visual perception	connexon complex|integral to membrane				pancreas(1)	1		all_cancers(29;1.4e-21)|all_epithelial(30;8.75e-19)|all_lung(29;1.28e-17)|Lung SC(185;0.0257)|Ovarian(182;0.0822)		all cancers(112;0.000554)|Epithelial(112;0.000872)|OV - Ovarian serous cystadenocarcinoma(117;0.0105)|Lung(94;0.0251)|LUSC - Lung squamous cell carcinoma(192;0.0784)		AAGTACTGGCCGGCGATGAAG	0.652			NA											19	10					1.67942e-08	1.97446e-08	0.006122	1	0
SACS	26278	broad.mit.edu	37	13	23905743	23905743	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:23905743G>C	uc001uon.2	-	10	12861	c.12272C>G	c.(12271-12273)TCA>TGA	p.S4091*	SACS_uc001uoo.2_Nonsense_Mutation_p.S3944*|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4091					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TTTACTGTCTGAATGTTGAAT	0.343			NA											22	3					0	0	0.001882	0	0
ATP12A	479	broad.mit.edu	37	13	25274899	25274899	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:25274899T>C	uc001upp.2	+	13	1907	c.1720T>C	c.(1720-1722)TAC>CAC	p.Y574H	ATP12A_uc010aaa.2_Missense_Mutation_p.Y580H	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	574	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	CTGTCATCTCTACCTGCCAGC	0.408	Pancreas(156;1582 1935 18898 22665 26498)		NA											12	7					0	0	0.001368	0	0
CENPJ	55835	broad.mit.edu	37	13	25480995	25480995	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:25480995T>A	uc001upt.3	-	7	1434	c.1181A>T	c.(1180-1182)AAA>ATA	p.K394I	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'Flank	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	394					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		TTCTTTGCCTTTTTGAAACTT	0.403			NA											16	4					0	0	0.004007	0	0
FAM123A	219287	broad.mit.edu	37	13	25744644	25744644	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:25744644G>T	uc001uqb.2	-	1	1214	c.1114C>A	c.(1114-1116)CTG>ATG	p.L372M	FAM123A_uc001uqa.2_Intron|FAM123A_uc001uqc.2_Intron	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	372										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAGCTTTTCAGTGAAGTCACG	0.463			NA											13	4					0.000422831	0.000446373	0.004007	1	0
PAN3	255967	broad.mit.edu	37	13	28835536	28835536	+	Splice_Site	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:28835536A>G	uc001urz.2	+	8	924	c.916_splice	c.e8-2	p.E306_splice	PAN3_uc010tdo.1_Splice_Site_p.E452_splice|PAN3_uc001ury.2_Splice_Site_p.E140_splice|PAN3_uc001urx.2_Splice_Site_p.E252_splice	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease						nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TTTGTTTCATAGGAGCTGATC	0.294			NA											11	3					0	0	0.000978	0	0
HSPH1	10808	broad.mit.edu	37	13	31724221	31724221	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:31724221C>A	uc001utj.2	-	8	1405	c.1007G>T	c.(1006-1008)AGT>ATT	p.S336I	HSPH1_uc001utk.2_Missense_Mutation_p.S336I|HSPH1_uc010aaw.2_Missense_Mutation_p.S295I|HSPH1_uc001utl.2_Missense_Mutation_p.S338I|HSPH1_uc010tds.1_Missense_Mutation_p.S260I|HSPH1_uc010tdt.1_RNA	NM_006644	NP_006635	Q92598	HS105_HUMAN	heat shock 105kD	336					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding				0		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CTCAACTGCACTCACATCTTC	0.398			NA											21	15					0.00121646	0.00126827	0.008871	1	0
RXFP2	122042	broad.mit.edu	37	13	32356837	32356837	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:32356837T>C	uc001utt.2	+	11	953	c.882T>C	c.(880-882)GGT>GGC	p.G294G	RXFP2_uc010aba.2_Intron	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	294	LRR 7.|Extracellular (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		ATCAAATTGGTTTTGTTCCAG	0.388			NA											21	9					0	0	0.003954	0	0
FRY	10129	broad.mit.edu	37	13	32802711	32802711	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:32802711G>T	uc001utx.2	+	40	5821	c.5325G>T	c.(5323-5325)ATG>ATT	p.M1775I	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1775					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TCCCACAGATGACCCAGGAGG	0.532			NA											49	17					3.77016e-25	5.98644e-25	0.003214	1	0
PDS5B	23047	broad.mit.edu	37	13	33344486	33344486	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:33344486G>T	uc010abf.2	+	32	4010	c.3852G>T	c.(3850-3852)CCG>CCT	p.P1284P	PDS5B_uc010abg.2_RNA	NM_015032	NP_055847	Q9NTI5	PDS5B_HUMAN	PDS5, regulator of cohesion maintenance, homolog	1284					cell division|cell proliferation|mitotic sister chromatid cohesion|negative regulation of cell proliferation	chromatin|nucleus	ATP binding|DNA binding|identical protein binding			ovary(2)|lung(1)|pancreas(1)	4		Lung SC(185;0.0367)		all cancers(112;5.55e-06)|Epithelial(112;2.7e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00303)|BRCA - Breast invasive adenocarcinoma(63;0.0204)		AGAATAGTCCGCCAAAAAAGG	0.408			NA											12	2					1.08611e-07	1.2533e-07	0.000978	1	0
POSTN	10631	broad.mit.edu	37	13	38153997	38153997	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:38153997C>A	uc001uwo.3	-	12	1778	c.1660_splice	c.e12+1	p.R554_splice	POSTN_uc010tet.1_Splice_Site_p.R82_splice|POSTN_uc001uwp.3_Splice_Site_p.R554_splice|POSTN_uc001uwr.2_Splice_Site_p.R554_splice|POSTN_uc001uwq.2_Splice_Site_p.R554_splice|POSTN_uc010teu.1_Splice_Site_p.R554_splice|POSTN_uc010tev.1_Splice_Site_p.R554_splice|POSTN_uc010tew.1_Splice_Site_p.R554_splice|POSTN_uc010tex.1_Splice_Site_p.R469_splice	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTTCCACTTACGTATCAGAAT	0.403			NA											10	4					0.000673444	0.000705548	0.008291	1	0
POSTN	10631	broad.mit.edu	37	13	38161012	38161012	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:38161012A>T	uc001uwo.3	-	6	778	c.660T>A	c.(658-660)AAT>AAA	p.N220K	POSTN_uc001uwp.3_Missense_Mutation_p.N220K|POSTN_uc001uwr.2_Missense_Mutation_p.N220K|POSTN_uc001uwq.2_Missense_Mutation_p.N220K|POSTN_uc010teu.1_Missense_Mutation_p.N220K|POSTN_uc010tev.1_Missense_Mutation_p.N220K|POSTN_uc010tew.1_Missense_Mutation_p.N220K|POSTN_uc010tex.1_Missense_Mutation_p.N135K	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1	220	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GGACAACACCATTTGTTGCAA	0.383			NA											16	7					0	0	0.004007	0	0
COG6	57511	broad.mit.edu	37	13	40293944	40293944	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:40293944C>A	uc001uxh.2	+	15	1664	c.1564C>A	c.(1564-1566)CTG>ATG	p.L522M	COG6_uc001uxi.2_Missense_Mutation_p.L470M|COG6_uc010acb.2_Missense_Mutation_p.L522M	NM_020751	NP_065802	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6 isoform	522					protein transport	Golgi membrane|Golgi transport complex				kidney(1)|skin(1)	2		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		TGACAGACGTCTGGAAATGCT	0.343			NA											16	5					3.52763e-06	3.90747e-06	0.00499	1	0
KIAA0564	23078	broad.mit.edu	37	13	42393467	42393467	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:42393467C>A	uc001uyj.2	-	15	1826	c.1756G>T	c.(1756-1758)GTT>TTT	p.V586F	KIAA0564_uc001uyk.2_Missense_Mutation_p.V586F	NM_015058	NP_055873	A3KMH1	K0564_HUMAN	hypothetical protein LOC23078 isoform a	586						extracellular region	ATP binding|ATPase activity			ovary(3)|upper_aerodigestive_tract(1)|kidney(1)|skin(1)	6		Lung NSC(96;4.61e-06)|Prostate(109;0.0167)|Lung SC(185;0.0262)|Breast(139;0.0854)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000368)|GBM - Glioblastoma multiforme(144;0.0033)|BRCA - Breast invasive adenocarcinoma(63;0.0969)		CTTCCAATAACAGGGGGTTCT	0.373			NA											15	8					2.23348e-06	2.47965e-06	0.004007	1	0
CAB39L	81617	broad.mit.edu	37	13	49906179	49906179	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:49906179T>A	uc001vcw.2	-	8	1236	c.738A>T	c.(736-738)ACA>ACT	p.T246T	CAB39L_uc001vcx.2_Silent_p.T246T|CAB39L_uc010adf.2_Silent_p.T243T	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	246					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		TGATATACTTTGTCATGATGG	0.438			NA											72	57					0	0	0.00361	0	0
RCBTB1	55213	broad.mit.edu	37	13	50108290	50108290	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:50108290T>G	uc001vde.1	-	13	1825	c.1564A>C	c.(1564-1566)AAA>CAA	p.K522Q		NM_018191	NP_060661	Q8NDN9	RCBT1_HUMAN	regulator of chromosome condensation (RCC1) and	522					cell cycle|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(1)	1		Lung NSC(96;2.1e-05)|Breast(56;0.00015)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;4.7e-09)		TTACTGGCTTTAGCAATGAAT	0.453			NA											33	80					0	0	0.002836	0	0
DHRS12	79758	broad.mit.edu	37	13	52351249	52351249	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:52351249T>C	uc001vfq.2	-	6	505	c.457A>G	c.(457-459)ATT>GTT	p.I153V	DHRS12_uc001vfr.1_Missense_Mutation_p.I104V|DHRS12_uc001vfs.1_Missense_Mutation_p.I104V			A0PJE2	DHR12_HUMAN	RecName: Full=Dehydrogenase/reductase SDR family member 12;          EC=1.1.-.-;	153							binding|oxidoreductase activity				0		Breast(56;0.00173)|Prostate(109;0.00899)|Lung NSC(96;0.0199)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.81e-08)		GTCGTGAGAATGTACACACCT	0.572			NA											29	24					0	0	0.008361	0	0
OLFM4	10562	broad.mit.edu	37	13	53616220	53616220	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:53616220G>T	uc001vhl.2	+	3	533	c.533G>T	c.(532-534)GGT>GTT	p.G178V	OLFM4_uc001vhk.1_Intron	NM_006418	NP_006409	Q6UX06	OLFM4_HUMAN	olfactomedin 4 precursor	178	Potential.				cell adhesion	extracellular space				skin(1)	1		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		GAGAGTTTTGGTGGAAGCTCA	0.428			NA											5	5					0.000602214	0.000632636	0.000602	1	0
PCDH17	27253	broad.mit.edu	37	13	58208476	58208476	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:58208476G>C	uc001vhq.1	+	1	2688	c.1796G>C	c.(1795-1797)CGC>CCC	p.R599P	PCDH17_uc010aec.1_Missense_Mutation_p.R599P	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	599	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CAGGTGCCGCGCAACGCTGGC	0.647	Melanoma(72;952 1291 1619 12849 33676)		NA											13	5					0	0	0.00245	0	0
DIAPH3	81624	broad.mit.edu	37	13	60590082	60590082	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:60590082C>A	uc001vht.2	-	7	955	c.736G>T	c.(736-738)GTC>TTC	p.V246F	DIAPH3_uc001vhu.2_5'Flank|DIAPH3_uc001vhw.1_Missense_Mutation_p.V235F|DIAPH3_uc010aed.1_Missense_Mutation_p.V200F|DIAPH3_uc010aee.1_Missense_Mutation_p.V176F|uc001vhx.2_Intron|uc001vhy.2_Intron	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	246	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		CACTGTATGACTTTATGTTGA	0.313			NA											9	2					1.08611e-07	1.2533e-07	0.000978	1	0
PCDH20	64881	broad.mit.edu	37	13	61986284	61986284	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:61986284C>T	uc001vid.3	-	2	2312	c.1948G>A	c.(1948-1950)GAA>AAA	p.E650K	PCDH20_uc010thj.1_Missense_Mutation_p.E650K	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	623	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		GGAAAGTTTTCAGGCACAAAA	0.478			NA											23	10					0	0	0.00333	0	0
PCDH9	5101	broad.mit.edu	37	13	67801402	67801402	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:67801402T>A	uc001vik.2	-	2	1863	c.1171A>T	c.(1171-1173)AAG>TAG	p.K391*	PCDH9_uc001vil.2_Nonsense_Mutation_p.K391*|PCDH9_uc010thl.1_Nonsense_Mutation_p.K391*|PCDH9_uc001vin.3_Nonsense_Mutation_p.K391*	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	391	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TCTGTGTCCTTATCTGAAACT	0.378			NA											54	42					0	0	0.00361	0	0
DACH1	1602	broad.mit.edu	37	13	72440789	72440789	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:72440789G>T	uc010thn.1	-	1	542	c.119C>A	c.(118-120)CCG>CAG	p.P40Q	DACH1_uc010tho.1_Missense_Mutation_p.P40Q|DACH1_uc010thp.1_Missense_Mutation_p.P40Q	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	40					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GGAAGGAGCCGGAGACGAAGT	0.677			NA											8	14					5.18039e-06	5.70876e-06	0.00308	1	0
LOC647288	647288	broad.mit.edu	37	13	75814255	75814255	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:75814255T>C	uc010ths.1	-	1	263	c.222A>G	c.(220-222)AGA>AGG	p.R74R		NR_027466				Homo sapiens mRNA; cDNA DKFZp434F0327 (from clone DKFZp434F0327).												0						GTTTTTTCTCTCTTCCCACAT	0.368			NA											28	83					0	0	0.005443	0	0
CLN5	1203	broad.mit.edu	37	13	77569290	77569290	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:77569290A>G	uc001vkc.2	+	2	441	c.413A>G	c.(412-414)GAT>GGT	p.D138G		NM_006493	NP_006484	O75503	CLN5_HUMAN	ceroid-lipofuscinosis, neuronal 5	89					brain development|cell death|lysosomal lumen acidification|neuron maturation|protein catabolic process	endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0503)		ATGGAGGGTGATGATGACATT	0.418			NA											24	58					0	0	0.00278	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453925	84453925	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:84453925G>T	uc001vlk.2	-	1	2604	c.1718C>A	c.(1717-1719)TCC>TAC	p.S573Y		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	573	LRRCT 2.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTCGTCATTGGAGAGGAGCAT	0.542			NA											18	8					5.03518e-11	6.25436e-11	0.007413	1	0
SLITRK1	114798	broad.mit.edu	37	13	84455557	84455557	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:84455557C>G	uc001vlk.2	-	1	972	c.86G>C	c.(85-87)TGT>TCT	p.C29S		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	29	LRRNT.|Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		ATTGCAGGAACAGATCTTCTC	0.468			NA											34	49					0	0	0.002836	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328109	88328109	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:88328109G>A	uc001vln.2	+	2	685	c.466G>A	c.(466-468)GAG>AAG	p.E156K	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	156	LRR 4.|Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GGAGAACCTGGAGTACCTACA	0.448			NA											23	63					0	0	0.001882	0	0
SLITRK5	26050	broad.mit.edu	37	13	88330362	88330362	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:88330362G>T	uc001vln.2	+	2	2938	c.2719G>T	c.(2719-2721)GGG>TGG	p.G907W	SLITRK5_uc010tic.1_Missense_Mutation_p.G666W	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	907	Cytoplasmic (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CCCGGGGGCAGGGGACAGCAG	0.557			NA											25	114					4.47668e-21	6.73766e-21	0.003954	1	0
DCT	1638	broad.mit.edu	37	13	95120999	95120999	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:95120999C>A	uc001vlv.3	-	2	1022	c.595_splice	c.e2+1	p.G199_splice	DCT_uc010afh.2_Splice_Site_p.G199_splice	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1						epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		AAAAAACCCACCTAATAATGT	0.408			NA											72	51					3.41413e-29	5.63871e-29	0.00361	1	0
OXGR1	27199	broad.mit.edu	37	13	97639385	97639386	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:97639385_97639386GG>TT	uc001vmx.1	-	4	872_873	c.628_629CC>AA	c.(628-630)CCC>AAC	p.P210N	OXGR1_uc010afr.1_Missense_Mutation_p.P210N	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	210	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TATCACCAAGGGGAGGCAGAAA	0.475			NA											31	34					0	0	0.004672	0	0
SLC15A1	6564	broad.mit.edu	37	13	99361875	99361875	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:99361875A>T	uc001vno.2	-	14	1095	c.1018T>A	c.(1018-1020)TTC>ATC	p.F340I		NM_005073	NP_005064	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide	340	Helical; (Potential).				digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			ovary(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	ACAGCATCGAAGATCGGGACC	0.517			NA											27	26					0	0	0.008361	0	0
KDELC1	79070	broad.mit.edu	37	13	103450906	103450906	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:103450906G>T	uc001vpq.3	-	1	499	c.115C>A	c.(115-117)CTA>ATA	p.L39I	KDELC1_uc001vpr.3_5'UTR|BIVM_uc001vps.2_5'Flank|BIVM_uc010agc.2_5'Flank	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	39	Filamin.					endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TCTGCTTTTAGCCCGGGTCCC	0.527			NA											34	17					1.22384e-17	1.73272e-17	0.002836	1	0
ERCC5	2073	broad.mit.edu	37	13	103514619	103514619	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:103514619G>T	uc001vpw.2	+	8	1563	c.1120G>T	c.(1120-1122)GCA>TCA	p.A374S	ERCC5_uc001vpu.1_Missense_Mutation_p.A828S|ERCC5_uc010tjb.1_Missense_Mutation_p.A374S|ERCC5_uc010tjc.1_RNA|ERCC5_uc010tjd.1_Missense_Mutation_p.A206S	NM_000123	NP_000114	P28715	ERCC5_HUMAN	XPG-complementing protein	374					negative regulation of apoptosis|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|response to UV-C|transcription-coupled nucleotide-excision repair|UV protection	nucleoplasm	bubble DNA binding|double-stranded DNA binding|endodeoxyribonuclease activity|metal ion binding|protein homodimerization activity|protein N-terminus binding|single-stranded DNA binding			ovary(4)|lung(1)|central_nervous_system(1)|skin(1)	7	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TGGGAGGAACGCACCTGCTGC	0.522			NA	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				45	30					5.78141e-17	8.04407e-17	0.003214	1	0
FAM155A	728215	broad.mit.edu	37	13	108518057	108518057	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:108518057C>A	uc001vql.2	-	1	1404	c.888G>T	c.(886-888)TCG>TCT	p.S296S		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	296						integral to membrane	binding			skin(1)	1						AGGATTTCACCGAGTACTCCT	0.498			NA											42	36					1.96642e-18	2.81708e-18	0.006999	1	0
MYO16	23026	broad.mit.edu	37	13	109777616	109777616	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:109777616G>T	uc001vqt.1	+	30	3752	c.3626G>T	c.(3625-3627)CGG>CTG	p.R1209L	MYO16_uc010agk.1_Missense_Mutation_p.R1231L|MYO16_uc010tjh.1_Missense_Mutation_p.R721L	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	1209					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GACATTGCCCGGGAAAATGAC	0.478			NA											16	23					3.35478e-16	4.61133e-16	0.003163	1	0
TMCO3	55002	broad.mit.edu	37	13	114202690	114202690	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr13:114202690G>T	uc001vtu.3	+	12	2204	c.1843G>T	c.(1843-1845)GCG>TCG	p.A615S		NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	615	Helical; (Potential).					integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GATCGTCTCTGCGGGGCTTGC	0.627			NA											43	32					4.64027e-19	6.73239e-19	0.00361	1	0
OR11H12	440153	broad.mit.edu	37	14	19378079	19378079	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:19378079G>T	uc010tkp.1	+	1	486	c.486G>T	c.(484-486)CTG>CTT	p.L162L		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	olfactory receptor, family 11, subfamily H,	162	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGTCATACTGTGCTGGGTTT	0.473			NA											65	313					1.37693e-34	2.3671e-34	0.00361	1	0
OR4Q3	441669	broad.mit.edu	37	14	20215914	20215914	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20215914G>T	uc010tkt.1	+	1	328	c.328G>T	c.(328-330)GCC>TCC	p.A110S		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	110	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTTCTAGGAGCCAGTGAGAT	0.488			NA											13	142					1.5842e-08	1.8682e-08	0.001855	1	0
OR4M1	441670	broad.mit.edu	37	14	20248716	20248716	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20248716C>G	uc010tku.1	+	1	235	c.235C>G	c.(235-237)CCT>GCT	p.P79A		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	79	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATTACAGCCCCTAAAATGCT	0.443			NA											139	610					0	0	0.00361	0	0
OR4K2	390431	broad.mit.edu	37	14	20344691	20344691	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20344691C>A	uc001vwh.1	+	1	265	c.265C>A	c.(265-267)CAC>AAC	p.H89N		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	89	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCTAACAGGTCACAAAACCAT	0.408			NA											191	181					3.43769e-75	6.44234e-75	0.00361	1	0
OR4K5	79317	broad.mit.edu	37	14	20388871	20388871	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20388871A>G	uc010tkw.1	+	1	106	c.106A>G	c.(106-108)ACA>GCA	p.T36A		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	36	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTGTTGTATACAGTCATTGT	0.403			NA											61	274					0	0	0.00361	0	0
OR4K13	390433	broad.mit.edu	37	14	20502265	20502266	+	Missense_Mutation	DNP	TA	TA	AT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20502265_20502266TA>AT	uc010tkz.1	-	1	652_653	c.652_653TA>AT	c.(652-654)TAT>ATT	p.Y218I		NM_001004714	NP_001004714	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K,	218	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TATGACTCCATAGGAGACAAGC	0.485			NA											52	9					0	0	0.004672	0	0
OR4L1	122742	broad.mit.edu	37	14	20528666	20528666	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20528666C>A	uc001vwn.1	+	1	463	c.463C>A	c.(463-465)CAC>AAC	p.H155N		NM_001004717	NP_001004717	Q8NH43	OR4L1_HUMAN	olfactory receptor, family 4, subfamily L,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		TGGTTTTTTACACTCCATAAG	0.403			NA											81	13					7.31121e-38	1.27501e-37	0.00361	1	0
OR11H6	122748	broad.mit.edu	37	14	20692206	20692206	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20692206C>A	uc010tlc.1	+	1	338	c.338C>A	c.(337-339)TCT>TAT	p.S113Y		NM_001004480	NP_001004480	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H,	113	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		ATCTCCTTCTCTGGTTGCTTC	0.413			NA											74	10					1.356e-25	2.162e-25	0.00361	1	0
PNP	4860	broad.mit.edu	37	14	20940629	20940629	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:20940629A>T	uc001vxo.3	+	2	316	c.174A>T	c.(172-174)CGA>CGT	p.R58R	PNP_uc010ahm.1_Silent_p.R58R|PNP_uc010ahn.2_Silent_p.R58R|PNP_uc001vxn.3_5'UTR	NM_000270	NP_000261	P00491	PNPH_HUMAN	nucleoside phosphorylase	58					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			ovary(2)	2					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	ACTTTCCCCGAAGTACAGGTA	0.468			NA											11	15					0	0	0.000978	0	0
CHD8	57680	broad.mit.edu	37	14	21863490	21863490	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:21863490C>A	uc001was.1	-	29	4406	c.4312G>T	c.(4312-4314)GAT>TAT	p.D1438Y	CHD8_uc001war.1_Missense_Mutation_p.D1334Y	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1717					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		ATCTCCTCATCCATCATCATC	0.468			NA											4	10					0.00024832	0.000262719	0.009096	1	0
CEBPE	1053	broad.mit.edu	37	14	23588155	23588155	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:23588155C>A	uc001wiv.1	-	1	320	c.146G>T	c.(145-147)GGG>GTG	p.G49V		NM_001805	NP_001796	Q15744	CEBPE_HUMAN	CCAAT/enhancer binding protein epsilon	49						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0064)		CTGCTCTTCCCCAGACTCGAT	0.647	NSCLC(63;1230 1818 14565 22565)		NA											55	12					1.78197e-24	2.80189e-24	0.00361	1	0
TM9SF1	10548	broad.mit.edu	37	14	24662025	24662025	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:24662025C>T	uc001wnb.1	-	3	1144	c.796G>A	c.(796-798)GCT>ACT	p.A266T	IPO4_uc001wmz.1_5'Flank|TM9SF1_uc010toa.1_Missense_Mutation_p.A179T|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.A501T|TM9SF1_uc001wnc.2_Missense_Mutation_p.A266T|TM9SF1_uc001wnd.2_Missense_Mutation_p.A122T	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	266					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		TTGTACCGAGCCAGGTCATTC	0.473			NA											63	71					0	0	0.00361	0	0
TM9SF1	10548	broad.mit.edu	37	14	24662418	24662418	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:24662418C>T	uc001wnb.1	-	3	751	c.403G>A	c.(403-405)GAC>AAC	p.D135N	IPO4_uc001wmz.1_5'Flank|TM9SF1_uc010toa.1_Missense_Mutation_p.D48N|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.D370N|TM9SF1_uc001wnc.2_Missense_Mutation_p.D135N|TM9SF1_uc001wnd.2_5'UTR	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	135					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		ATTGGCAAGTCATCTACCACA	0.507			NA											51	45					0	0	0.00361	0	0
TM9SF1	10548	broad.mit.edu	37	14	24664018	24664018	+	Missense_Mutation	SNP	C	C	T	rs148543793		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:24664018C>T	uc001wnb.1	-	2	556	c.208G>A	c.(208-210)GAG>AAG	p.E70K	TM9SF1_uc010toa.1_5'UTR|TM9SF1_uc001wna.1_RNA|TM9SF1_uc010tob.1_Missense_Mutation_p.E305K|TM9SF1_uc001wnc.2_Missense_Mutation_p.E70K|TM9SF1_uc001wnd.2_5'Flank	NM_006405	NP_006396	O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1 isoform a	70					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				ovary(1)	1				GBM - Glioblastoma multiforme(265;0.0183)		CGTATCTTCTCAGGGCAGCAG	0.507			NA											468	393					0	0	0.00361	0	0
CTSG	1511	broad.mit.edu	37	14	25042994	25042994	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:25042994A>T	uc001wpq.2	-	5	654	c.617T>A	c.(616-618)CTG>CAG	p.L206Q		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	206	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		ATTGTTACACAGCAGGGGGCC	0.592			NA											81	21					0	0	0.00361	0	0
CTSG	1511	broad.mit.edu	37	14	25043928	25043928	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:25043928G>T	uc001wpq.2	-	3	329	c.292C>A	c.(292-294)CCT>ACT	p.P98T		NM_001911	NP_001902	P08311	CATG_HUMAN	cathepsin G preproprotein	98	Peptidase S1.				immune response|proteolysis	cell surface|extracellular space|plasma membrane|stored secretory granule	heparin binding|serine-type endopeptidase activity			ovary(2)	2				GBM - Glioblastoma multiforme(265;0.0269)		TTATATTGAGGGTGGCGGATG	0.527			NA											42	6					9.73076e-26	1.55403e-25	0.006999	1	0
NOVA1	4857	broad.mit.edu	37	14	26917170	26917170	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:26917170C>A	uc001wpy.2	-	5	1837	c.1519G>T	c.(1519-1521)GGT>TGT	p.G507C	NOVA1_uc001wpz.2_Missense_Mutation_p.G483C|NOVA1_uc001wqa.2_Missense_Mutation_p.G385C	NM_002515	NP_002506	P51513	NOVA1_HUMAN	neuro-oncological ventral antigen 1 isoform 1	510					locomotory behavior|RNA splicing|synaptic transmission	nucleus	RNA binding			skin(2)|upper_aerodigestive_tract(1)|breast(1)|liver(1)	5				GBM - Glioblastoma multiforme(265;0.0135)		GGCACTCAACCCACTTTCTGA	0.428			NA											89	35					6.03386e-27	9.75709e-27	0.00361	1	0
FOXG1	2290	broad.mit.edu	37	14	29237673	29237673	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:29237673C>T	uc001wqe.2	+	1	1387	c.1188C>T	c.(1186-1188)TGC>TGT	p.C396C		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	396	Interaction with KDM5B.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CGGTGCCCTGCTCTGGGACCT	0.682			NA											18	3					0	0	0.008871	0	0
FOXG1	2290	broad.mit.edu	37	14	29237796	29237796	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:29237796G>T	uc001wqe.2	+	1	1510	c.1311G>T	c.(1309-1311)AGG>AGT	p.R437S		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	437					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TGAGCGCCAGGGCCGCGTCCT	0.637			NA											31	6					6.97489e-18	9.91141e-18	0.004878	1	0
G2E3	55632	broad.mit.edu	37	14	31066643	31066643	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:31066643G>T	uc001wqk.2	+	7	700	c.546G>T	c.(544-546)GCG>GCT	p.A182A	G2E3_uc010tpe.1_Silent_p.A136A|G2E3_uc010tpf.1_Silent_p.A136A	NM_017769	NP_060239	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin ligase	182	PHD-type 2; degenerate.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CAATAAATGCGGGAGTGTTTT	0.313			NA											51	123					2.01807e-28	3.31883e-28	0.00361	1	0
STRN3	29966	broad.mit.edu	37	14	31371816	31371816	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:31371816A>C	uc001wqu.2	-	16	2279	c.2063T>G	c.(2062-2064)GTA>GGA	p.V688G	STRN3_uc001wqv.2_Missense_Mutation_p.V604G|STRN3_uc010tpj.1_RNA	NM_001083893	NP_001077362	Q13033	STRN3_HUMAN	nuclear autoantigen isoform 1	688	WD 4.				negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		GGGATGACTTACTACTCTGTT	0.299			NA											24	33					0	0	0.005443	0	0
HECTD1	25831	broad.mit.edu	37	14	31583534	31583534	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:31583534T>A	uc001wrc.1	-	31	6120	c.5631A>T	c.(5629-5631)AGA>AGT	p.R1877S	HECTD1_uc001wra.1_Missense_Mutation_p.R3S|HECTD1_uc001wrb.1_Missense_Mutation_p.R3S|HECTD1_uc001wrd.1_Missense_Mutation_p.R1345S	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1877					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CCTTCATTTCTCTGTACATGA	0.249			NA											6	6					0	0	0.001984	0	0
AKAP6	9472	broad.mit.edu	37	14	33292940	33292940	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:33292940G>T	uc001wrq.2	+	13	6091	c.5921G>T	c.(5920-5922)AGC>ATC	p.S1974I		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1974					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GAAAATCAAAGCACTGCCTCT	0.388	Melanoma(49;821 1200 7288 13647 42351)		NA											36	44					6.29468e-14	8.23118e-14	0.004878	1	0
Unknown	0	broad.mit.edu	37	14	36841088	36841088	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:36841088T>C	uc001wtp.2	+	1	719	c.470T>C	c.(469-471)CTT>CCT	p.L157P		NM_199286	NP_954980			stella												NA						ACCAAGCCACTTCAGCCATAA	0.378			NA											71	277					0	0	0.00361	0	0
L2HGDH	79944	broad.mit.edu	37	14	50778849	50778849	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:50778849T>C	uc001wxu.2	-	1	99	c.20A>G	c.(19-21)TAT>TGT	p.Y7C	L2HGDH_uc010tqn.1_Missense_Mutation_p.Y7C|L2HGDH_uc010tqo.1_Missense_Mutation_p.Y7C|ATP5S_uc001wxv.2_5'Flank|ATP5S_uc001wxw.1_5'Flank|ATP5S_uc001wxx.1_5'Flank	NM_024884	NP_079160	Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase precursor	7					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			ovary(2)	2	all_epithelial(31;0.000599)|Breast(41;0.0102)					ACCAACCAAATAACGCAGCGC	0.687			NA									OREG0022670	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	6					0	0	0.000978	0	0
TRIM9	114088	broad.mit.edu	37	14	51475904	51475904	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:51475904C>A	uc001wyx.3	-	5	1965	c.1200G>T	c.(1198-1200)TGG>TGT	p.W400C	TRIM9_uc001wyy.2_Missense_Mutation_p.W400C|TRIM9_uc001wyz.3_Missense_Mutation_p.W400C	NM_015163	NP_055978	Q9C026	TRIM9_HUMAN	tripartite motif protein 9 isoform 1	400	COS.				proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			skin(2)|lung(1)	3	all_epithelial(31;0.00418)|Breast(41;0.148)					TGCCTTTACCCCACTGATCCT	0.493			NA											22	44					3.10358e-05	3.37399e-05	0.002299	1	0
GNG2	54331	broad.mit.edu	37	14	52417474	52417474	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:52417474C>A	uc001wzi.2	+	3	607	c.78C>A	c.(76-78)GAC>GAA	p.D26E	GNG2_uc001wzh.2_RNA|GNG2_uc010aoc.1_Intron|GNG2_uc001wzj.2_RNA|GNG2_uc001wzk.2_Missense_Mutation_p.D26E	NM_053064	NP_444292	P59768	GBG2_HUMAN	guanine nucleotide binding protein (G protein),	26					cellular response to glucagon stimulus|energy reserve metabolic process|platelet activation|synaptic transmission	heterotrimeric G-protein complex	protein binding|signal transducer activity				0	all_epithelial(31;0.0659)|Breast(41;0.0684)				Halothane(DB01159)	CCAATATCGACAGGATAAAGG	0.493			NA											13	32					2.27111e-07	2.59901e-07	0.001368	1	0
BMP4	652	broad.mit.edu	37	14	54416818	54416818	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:54416818C>T	uc001xal.3	-	3	1346	c.1159G>A	c.(1159-1161)GAT>AAT	p.D387N	BMP4_uc010aoh.2_Missense_Mutation_p.D387N|BMP4_uc001xao.3_Missense_Mutation_p.D387N|BMP4_uc001xan.3_Missense_Mutation_p.D387N	NM_130851	NP_570912	P12644	BMP4_HUMAN	bone morphogenetic protein 4 preproprotein	387					activation of MAPKK activity|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|BMP signaling pathway involved in heart induction|BMP signaling pathway involved in nephric duct formation|branching involved in ureteric bud morphogenesis|bronchus development|bud dilation involved in lung branching|cardiac septum development|cartilage development|endocardial cushion development|epithelial cell proliferation involved in lung morphogenesis|intermediate mesodermal cell differentiation|lung alveolus development|lymphoid progenitor cell differentiation|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|negative regulation of branching involved in ureteric bud morphogenesis|negative regulation of cell proliferation involved in heart morphogenesis|negative regulation of glomerular mesangial cell proliferation|negative regulation of glomerulus development|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|negative regulation of metanephric comma-shaped body morphogenesis|negative regulation of metanephric S-shaped body morphogenesis|negative regulation of mitosis|negative regulation of myoblast differentiation|negative regulation of phosphorylation|negative regulation of striated muscle tissue development|negative regulation of thymocyte apoptosis|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cardiac muscle fiber development|positive regulation of cartilage development|positive regulation of collagen biosynthetic process|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of kidney development|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|protein localization to nucleus|pulmonary artery endothelial tube morphogenesis|secondary heart field specification|SMAD protein signal transduction|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|steroid hormone mediated signaling pathway	extracellular space|proteinaceous extracellular matrix	BMP receptor binding|chemoattractant activity|cytokine activity|growth factor activity				0						TCATACTCATCCAGGTACAGC	0.483			NA											57	74					0	0	0.00361	0	0
DLGAP5	9787	broad.mit.edu	37	14	55625362	55625362	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:55625362C>G	uc001xbs.2	-	14	1968	c.1751G>C	c.(1750-1752)AGA>ACA	p.R584T	DLGAP5_uc001xbt.2_Missense_Mutation_p.R584T	NM_014750	NP_055565	Q15398	DLGP5_HUMAN	discs large homolog 7 isoform a	584					cell proliferation|cell-cell signaling|mitotic chromosome movement towards spindle pole|positive regulation of mitotic metaphase/anaphase transition	nucleus|spindle pole centrosome	phosphoprotein phosphatase activity|protein binding			ovary(1)|skin(1)	2						AATTCTCTCTCTCATTGCATT	0.393			NA											34	31					0	0	0.003755	0	0
FBXO34	55030	broad.mit.edu	37	14	55818810	55818810	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:55818810C>G	uc001xbu.2	+	2	1947	c.1702C>G	c.(1702-1704)CTT>GTT	p.L568V	FBXO34_uc001xbv.2_RNA|FBXO34_uc010aoo.2_Missense_Mutation_p.L568V	NM_017943	NP_060413	Q9NWN3	FBX34_HUMAN	F-box only protein 34	568										ovary(2)|lung(2)|skin(1)	5						AATCCAGCAGCTTTTGGAGCC	0.468			NA											37	69					0	0	0.004289	0	0
KIAA0831	22863	broad.mit.edu	37	14	55848823	55848823	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:55848823T>G	uc001xbx.1	-	6	770	c.734A>C	c.(733-735)TAC>TCC	p.Y245S	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Missense_Mutation_p.Y132S	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	245					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						TCCTGAGAGGTAAGTTGTCCT	0.537			NA											20	106					0	0	0.010504	0	0
KIAA0831	22863	broad.mit.edu	37	14	55848839	55848839	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:55848839C>A	uc001xbx.1	-	6	754	c.718G>T	c.(718-720)GCC>TCC	p.A240S	FBXO34_uc001xbv.2_Intron|KIAA0831_uc001xbw.1_Missense_Mutation_p.A127S	NM_014924	NP_055739	Q6ZNE5	BAKOR_HUMAN	Barkor	240					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding				0						GTCCTCCGGGCTTCAGCAAGC	0.522			NA											59	50					8.52622e-23	1.30871e-22	0.00361	1	0
PELI2	57161	broad.mit.edu	37	14	56757024	56757024	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:56757024G>T	uc001xch.2	+	5	832	c.546G>T	c.(544-546)ATG>ATT	p.M182I		NM_021255	NP_067078	Q9HAT8	PELI2_HUMAN	pellino 2	182					innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of protein phosphorylation|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	protein binding			ovary(1)	1						ACGGCCACATGGATGGGCTCA	0.537			NA											27	65					7.41945e-09	8.79241e-09	0.005443	1	0
OTX2	5015	broad.mit.edu	37	14	57268602	57268602	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:57268602G>T	uc001xcp.2	-	3	892	c.721C>A	c.(721-723)CAG>AAG	p.Q241K	OTX2_uc010aou.2_Missense_Mutation_p.Q241K|OTX2_uc001xcq.2_Missense_Mutation_p.Q249K	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	241					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CCATATCCCTGGGTGGAAAGA	0.507			NA											21	48					2.32416e-17	3.26903e-17	0.002299	1	0
DAAM1	23002	broad.mit.edu	37	14	59797982	59797982	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:59797982C>T	uc001xdz.1	+	14	1741	c.1616C>T	c.(1615-1617)CCC>CTC	p.P539L	DAAM1_uc001xea.1_Missense_Mutation_p.P539L	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	539	FH1.|Pro-rich.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CCAGGAGGGCCCTTTCCTTCC	0.453			NA											15	92					0	0	0.006122	0	0
SLC38A6	145389	broad.mit.edu	37	14	61512097	61512097	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:61512097T>G	uc001xfg.1	+	11	894	c.778T>G	c.(778-780)TTT>GTT	p.F260V	SLC38A6_uc001xfh.1_Missense_Mutation_p.F260V|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Missense_Mutation_p.F237V	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	260	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		GGCTTTTTCATTTCTCTGCCA	0.313			NA											4	35					0	0	0.000602	0	0
KCNH5	27133	broad.mit.edu	37	14	63175062	63175062	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:63175062G>T	uc001xfx.2	-	11	2182	c.2131C>A	c.(2131-2133)CAG>AAG	p.Q711K	KCNH5_uc001xfy.2_3'UTR	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	711	Calmodulin-binding (Potential).|Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTGAACTTCTGGAAGAGCTTT	0.547			NA											42	89					1.22674e-20	1.83206e-20	0.00874	1	0
KCNH5	27133	broad.mit.edu	37	14	63416986	63416986	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:63416986C>T	uc001xfx.2	-	7	1285	c.1234G>A	c.(1234-1236)GGA>AGA	p.G412R	KCNH5_uc001xfy.2_Missense_Mutation_p.G412R|KCNH5_uc001xfz.1_Missense_Mutation_p.G354R|KCNH5_uc001xga.2_Missense_Mutation_p.G354R	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	412	Extracellular (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TTGCTGGGTCCTCCTTCCCAT	0.468			NA											47	35					0	0	0.00361	0	0
SYNE2	23224	broad.mit.edu	37	14	64467393	64467393	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:64467393A>T	uc001xgm.2	+	28	3824	c.3594A>T	c.(3592-3594)ACA>ACT	p.T1198T	SYNE2_uc001xgl.2_Silent_p.T1198T	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1198	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAAGAGACACACTAAAGGAAA	0.308			NA											31	32					0	0	0.002096	0	0
ZBTB25	7597	broad.mit.edu	37	14	64954030	64954030	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:64954030G>A	uc001xhf.2	-	3	1102	c.919C>T	c.(919-921)CAG>TAG	p.Q307*	ZBTB25_uc001xhc.2_Intron|ZBTB25_uc001xhg.2_Nonsense_Mutation_p.Q307*	NM_006977	NP_008908	P24278	ZBT25_HUMAN	zinc finger protein 46	307						cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2				all cancers(60;0.00865)|OV - Ovarian serous cystadenocarcinoma(108;0.0102)|BRCA - Breast invasive adenocarcinoma(234;0.0469)		TCTGGCTGCTGTTCATTCTCC	0.473			NA											54	93					0	0	0.00361	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68251091	68251091	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:68251091C>A	uc001xka.2	-	20	3725	c.3586G>T	c.(3586-3588)GTG>TTG	p.V1196L	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.V1196L	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1196					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AGATGTGACACCAGTTGGGAA	0.483			NA											51	161					9.53978e-28	1.55696e-27	0.00361	1	0
ADAM21P1	145241	broad.mit.edu	37	14	70712480	70712480	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:70712480A>T	uc010ttg.1	-	1	2039	c.1388T>A	c.(1387-1389)CTG>CAG	p.L463Q		NR_003951				SubName: Full=ADAM21-like protein;												0						TCAGGAAGGCAGATGTGTGAC	0.507			NA											25	24					0	0	0.00278	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72152348	72152348	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:72152348G>C	uc001xms.2	+	10	3722	c.3374G>C	c.(3373-3375)CGG>CCG	p.R1125P	SIPA1L1_uc001xmt.2_Missense_Mutation_p.R1125P|SIPA1L1_uc001xmu.2_Missense_Mutation_p.R1125P|SIPA1L1_uc001xmv.2_Missense_Mutation_p.R1125P|SIPA1L1_uc010ttm.1_Missense_Mutation_p.R600P	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1125					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CTAGAGAGGCGGTAAGTGTGC	0.502			NA											8	34					0	0	0.00308	0	0
RGS6	9628	broad.mit.edu	37	14	72431520	72431520	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:72431520A>T	uc001xna.3	+	2	535	c.12A>T	c.(10-12)GGA>GGT	p.G4G	RGS6_uc010ttn.1_Silent_p.G4G|RGS6_uc001xmx.3_Silent_p.G4G|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Silent_p.G4G	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	4					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity	p.G4R(1)		upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		TGGCTCAAGGATCCGGGGATC	0.458	Ovarian(143;1926 2468 21071 48641)		NA											39	35					0	0	0.00874	0	0
RGS6	9628	broad.mit.edu	37	14	72961950	72961950	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:72961950T>A	uc001xna.3	+	13	1468	c.945T>A	c.(943-945)GCT>GCA	p.A315A	RGS6_uc010ttn.1_Silent_p.A315A|RGS6_uc001xmx.3_Silent_p.A315A|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Silent_p.A315A|RGS6_uc010ttp.1_Silent_p.A246A|RGS6_uc001xmz.1_Silent_p.A176A	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	315	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		ATGACGTTGCTTTGTGGGACA	0.408	Ovarian(143;1926 2468 21071 48641)		NA											29	60					0	0	0.002096	0	0
RGS6	9628	broad.mit.edu	37	14	72961952	72961952	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:72961952T>G	uc001xna.3	+	13	1470	c.947T>G	c.(946-948)TTG>TGG	p.L316W	RGS6_uc010ttn.1_Missense_Mutation_p.L316W|RGS6_uc001xmx.3_Missense_Mutation_p.L316W|RGS6_uc010tto.1_RNA|RGS6_uc001xmy.3_Missense_Mutation_p.L316W|RGS6_uc010ttp.1_Missense_Mutation_p.L247W|RGS6_uc001xmz.1_Missense_Mutation_p.L177W	NM_004296	NP_004287	P49758	RGS6_HUMAN	regulator of G-protein signalling 6	316	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			upper_aerodigestive_tract(1)|lung(1)|skin(1)	3				all cancers(60;0.00309)|BRCA - Breast invasive adenocarcinoma(234;0.0281)|STAD - Stomach adenocarcinoma(64;0.0302)|OV - Ovarian serous cystadenocarcinoma(108;0.0476)		GACGTTGCTTTGTGGGACATA	0.403	Ovarian(143;1926 2468 21071 48641)		NA											28	62					0	0	0.009535	0	0
DCAF4	26094	broad.mit.edu	37	14	73408452	73408452	+	Splice_Site	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:73408452G>C	uc001xng.2	+	5	572	c.352_splice	c.e5-1	p.I118_splice	DCAF4_uc001xnj.2_Splice_Site_p.I118_splice|DCAF4_uc010ttr.1_Splice_Site_p.I96_splice|DCAF4_uc001xnh.2_Splice_Site_p.I18_splice|DCAF4_uc010tts.1_Intron|DCAF4_uc010ttt.1_Splice_Site|DCAF4_uc001xni.2_Intron|DCAF4_uc001xnk.2_Splice_Site_p.I118_splice	NM_015604	NP_056419	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4 isoform 1							CUL4 RING ubiquitin ligase complex				ovary(1)|central_nervous_system(1)|skin(1)	3						AATAAATATAGATTGCCAGGA	0.368			NA											26	72					0	0	0.005443	0	0
ALDH6A1	4329	broad.mit.edu	37	14	74541699	74541699	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:74541699T>A	uc001xpo.2	-	2	169	c.70A>T	c.(70-72)AGT>TGT	p.S24C	C14orf45_uc001xpm.1_Intron|ALDH6A1_uc010asa.2_5'UTR|ALDH6A1_uc010tuq.1_Missense_Mutation_p.S24C	NM_005589	NP_005580	Q02252	MMSA_HUMAN	aldehyde dehydrogenase 6A1 precursor	24						mitochondrial matrix|nucleus	fatty-acyl-CoA binding|malonate-semialdehyde dehydrogenase (acetylating) activity|methylmalonate-semialdehyde dehydrogenase (acylating) activity				0				BRCA - Breast invasive adenocarcinoma(234;0.00354)	NADH(DB00157)	CAGGTGGGACTGGATTTCACC	0.368			NA											11	8					0	0	0.000978	0	0
LTBP2	4053	broad.mit.edu	37	14	75078231	75078231	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:75078231C>A	uc001xqa.2	-	1	804	c.417G>T	c.(415-417)GCG>GCT	p.A139A		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	139					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGAGAGCCGGCGCGGCCCGGG	0.751			NA											35	39					6.53348e-20	9.60893e-20	0.003755	1	0
NRXN3	9369	broad.mit.edu	37	14	79432645	79432645	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:79432645C>A	uc001xun.2	+	9	2045	c.1554C>A	c.(1552-1554)ACC>ACA	p.T518T	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.T643T	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	891	Extracellular (Potential).|Laminin G-like 5.				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AGGCTTACACCTCCATGCACC	0.498			NA											62	45					1.80625e-27	2.94296e-27	0.00361	1	0
NRXN3	9369	broad.mit.edu	37	14	79454368	79454368	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:79454368C>A	uc001xun.2	+	12	2518	c.2027C>A	c.(2026-2028)CCC>CAC	p.P676H	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Missense_Mutation_p.P801H	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1049	EGF-like 3.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		TTACTAGGACCCAGTACCACC	0.428			NA											21	20					3.62473e-10	4.41729e-10	0.001882	1	0
KCNK10	54207	broad.mit.edu	37	14	88729877	88729877	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:88729877G>T	uc001xwo.2	-	2	513	c.56C>A	c.(55-57)GCA>GAA	p.A19E	KCNK10_uc001xwm.2_Missense_Mutation_p.A24E|KCNK10_uc001xwn.2_Missense_Mutation_p.A24E	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	19	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GCACACCGGTGCTGCTGCGGG	0.562			NA											30	45					1.55811e-20	2.32156e-20	0.008361	1	0
C14orf102	55051	broad.mit.edu	37	14	90755006	90755006	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:90755006T>A	uc001xyi.1	-	11	2744	c.2713A>T	c.(2713-2715)AGC>TGC	p.S905C	C14orf102_uc010atp.1_Missense_Mutation_p.S410C|C14orf102_uc001xyj.1_Missense_Mutation_p.S674C|C14orf102_uc001xyk.1_Missense_Mutation_p.S97C	NM_017970	NP_060440	Q9H7Z3	CN102_HUMAN	hypothetical protein LOC55051 isoform 1	905							protein binding			ovary(2)|lung(1)	3		all_cancers(154;0.118)		COAD - Colon adenocarcinoma(157;0.218)		TTAGCCAGGCTAATTAGGCGG	0.483			NA											18	16					0	0	0.00499	0	0
TTC7B	145567	broad.mit.edu	37	14	91044511	91044511	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:91044511C>A	uc001xyp.2	-	19	2371	c.2249G>T	c.(2248-2250)CGG>CTG	p.R750L	TTC7B_uc001xyo.2_Missense_Mutation_p.R194L|TTC7B_uc010ats.2_RNA	NM_001010854	NP_001010854	Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	750	TPR 9.						binding			ovary(2)	2		Melanoma(154;0.222)				ATACCACCGCCGCGCCTCGTC	0.622			NA											13	21					9.31168e-06	1.02091e-05	0.001855	1	0
CCDC88C	440193	broad.mit.edu	37	14	91810001	91810001	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:91810001C>A	uc010aty.2	-	5	440	c.341G>T	c.(340-342)GGG>GTG	p.G114V	CCDC88C_uc010twk.1_Missense_Mutation_p.G78V	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	114					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				CATGCTCTTCCCTAGATCAAG	0.478			NA											8	12					1.11149e-13	1.44658e-13	0.008291	1	0
TRIP11	9321	broad.mit.edu	37	14	92471709	92471709	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:92471709G>A	uc001xzy.2	-	11	3399	c.2611C>T	c.(2611-2613)CGA>TGA	p.R871*	TRIP11_uc010auf.1_Nonsense_Mutation_p.R607*	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	871	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TCCCTGAGTCGTTCCAATTCT	0.413	Ovarian(84;609 1888 9852 42686)		NA	T	PDGFRB	AML								29	41					0	0	0.003271	0	0
SLC24A4	123041	broad.mit.edu	37	14	92792257	92792257	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:92792257G>T	uc001yak.2	+	2	149	c.125G>T	c.(124-126)TGG>TTG	p.W42L	SLC24A4_uc001yai.2_5'UTR|SLC24A4_uc010twm.1_Missense_Mutation_p.W59L|SLC24A4_uc001yaj.2_Missense_Mutation_p.W42L	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	59	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CCAGACACGTGGAGAAATAGA	0.463	NSCLC(10;315 435 10383 28450 38798)		NA											6	4					5.9392e-07	6.68982e-07	0.001168	1	0
KIAA1409	57578	broad.mit.edu	37	14	94044382	94044382	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94044382C>T	uc001ybv.1	+	15	1958	c.1875C>T	c.(1873-1875)ATC>ATT	p.I625I	KIAA1409_uc001ybs.1_Silent_p.I625I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	802						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATTGTTTCATCCTCATGTTTG	0.408			NA											15	24					0	0	0.003163	0	0
KIAA1409	57578	broad.mit.edu	37	14	94046646	94046646	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94046646A>T	uc001ybv.1	+	16	2137	c.2054A>T	c.(2053-2055)CAG>CTG	p.Q685L	KIAA1409_uc001ybs.1_Missense_Mutation_p.Q685L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	862						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		AACTTATGTCAGTCTAGTATC	0.468			NA											25	31					0	0	0.003954	0	0
KIAA1409	57578	broad.mit.edu	37	14	94088153	94088153	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94088153G>T	uc001ybv.1	+	28	4192	c.4109G>T	c.(4108-4110)CGG>CTG	p.R1370L	KIAA1409_uc001ybs.1_Missense_Mutation_p.R1348L	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1525						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TGCATAGATCGGTGTGACATA	0.453			NA											24	40					1.10923e-09	1.33494e-09	0.00278	1	0
KIAA1409	57578	broad.mit.edu	37	14	94120157	94120157	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94120157C>A	uc001ybv.1	+	35	5888	c.5805C>A	c.(5803-5805)GCC>GCA	p.A1935A	KIAA1409_uc001ybs.1_Silent_p.A1913A	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2090						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATCAGTTGGCCCCCAACGGCA	0.552			NA											112	140					1.9362e-44	3.47689e-44	0.00361	1	0
KIAA1409	57578	broad.mit.edu	37	14	94149022	94149022	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94149022G>A	uc001ybv.1	+	41	6536	c.6453G>A	c.(6451-6453)ATG>ATA	p.M2151I	KIAA1409_uc001ybs.1_Missense_Mutation_p.M2129I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2306						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GCAAGCAGATGATAGCCTCTG	0.289			NA											9	16					0	0	0.000978	0	0
KIAA1409	57578	broad.mit.edu	37	14	94152940	94152940	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94152940G>T	uc001ybv.1	+	42	6577	c.6494G>T	c.(6493-6495)TGT>TTT	p.C2165F	KIAA1409_uc001ybs.1_Missense_Mutation_p.C2143F	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	2320						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		GCGATGGAGTGTGTGAGGCAG	0.522			NA											11	24					1.08611e-07	1.2533e-07	0.000978	1	0
ASB2	51676	broad.mit.edu	37	14	94401024	94401024	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94401024A>T	uc001ycc.1	-	8	2231	c.1742T>A	c.(1741-1743)CTG>CAG	p.L581Q	ASB2_uc001ycb.1_Missense_Mutation_p.L275Q|ASB2_uc001ycd.2_Missense_Mutation_p.L629Q	NM_016150	NP_057234	Q96Q27	ASB2_HUMAN	ankyrin repeat and SOCS box-containing protein	581	SOCS box.				intracellular signal transduction					ovary(1)|pancreas(1)	2		all_cancers(154;0.13)		COAD - Colon adenocarcinoma(157;0.217)|Epithelial(152;0.232)		CTCGTATTTCAGGTATCTAAT	0.537			NA											23	33					0	0	0.00278	0	0
SERPINA10	51156	broad.mit.edu	37	14	94756523	94756523	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:94756523G>T	uc001yct.2	-	2	874	c.408C>A	c.(406-408)ACC>ACA	p.T136T	SERPINA10_uc001ycu.3_Silent_p.T136T	NM_016186	NP_057270	Q9UK55	ZPI_HUMAN	serine (or cysteine) proteinase inhibitor, clade	136					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		GCCCGGGCTTGGTGGGCTTCA	0.602			NA											23	21					2.98393e-07	3.40668e-07	0.00278	1	0
SERPINA4	5267	broad.mit.edu	37	14	95030432	95030432	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:95030432G>T	uc001ydk.2	+	2	679	c.613G>T	c.(613-615)GTC>TTC	p.V205F	SERPINA4_uc010avd.2_Missense_Mutation_p.V242F|SERPINA4_uc001ydl.2_Missense_Mutation_p.V205F	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	205					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		CAAGAAGGACGTCTTGATGGT	0.458			NA											23	53					5.45024e-15	7.30982e-15	0.00333	1	0
SERPINA13	388007	broad.mit.edu	37	14	95108049	95108049	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:95108049G>T	uc001ydt.2	+	2	654	c.566G>T	c.(565-567)CGG>CTG	p.R189L		NR_015340				RecName: Full=Serpin A13; Flags: Precursor;											lung(1)|skin(1)	2						CAGGGTCCCCGGCTCCTCCTG	0.632			NA											33	52					4.23469e-30	7.05417e-30	0.003271	1	0
DICER1	23405	broad.mit.edu	37	14	95584026	95584026	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:95584026C>A	uc001ydw.2	-	10	1624	c.1442G>T	c.(1441-1443)GGA>GTA	p.G481V	DICER1_uc001ydv.2_Missense_Mutation_p.G471V|DICER1_uc001ydx.2_Missense_Mutation_p.G481V	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	481	Helicase C-terminal.|Required for interaction with PRKRA and TARBP2.				negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AATGCCATGTCCAGTTATGAA	0.363			NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				19	27					9.95505e-16	1.35681e-15	0.002299	1	0
C14orf49	161176	broad.mit.edu	37	14	95922041	95922041	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:95922041G>A	uc001yei.3	-	5	825	c.810C>T	c.(808-810)CCC>CCT	p.P270P	C14orf49_uc010avi.2_Silent_p.P270P|C14orf49_uc001yej.1_Silent_p.P270P	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	270	Spectrin 1.|Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		CCTCGCCCCTGGGAAAATCTT	0.537			NA											32	50					0	0	0.002096	0	0
C14orf49	161176	broad.mit.edu	37	14	95942072	95942072	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:95942072G>T	uc001yei.3	-	1	102	c.87C>A	c.(85-87)GTC>GTA	p.V29V	C14orf49_uc010avi.2_Silent_p.V29V|C14orf49_uc001yej.1_Silent_p.V29V	NM_152592	NP_689805	Q6ZMZ3	SYNE3_HUMAN	nesprin-3	29	Cytoplasmic (Potential).				cytoskeletal anchoring at nuclear membrane	integral to membrane|nuclear outer membrane|SUN-KASH complex	actin binding			central_nervous_system(1)	1		all_cancers(154;0.0937)		COAD - Colon adenocarcinoma(157;0.245)		TGTTGTCATTGACCTGCAGCT	0.657			NA											4	15					0.00024832	0.000262719	0.009096	1	0
TCL6	27004	broad.mit.edu	37	14	96135931	96135931	+	Missense_Mutation	SNP	G	G	A	rs145339687	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:96135931G>A	uc001yeq.2	+	5	1704	c.235G>A	c.(235-237)GAC>AAC	p.D79N	TCL6_uc001yep.1_RNA|TCL6_uc001yes.2_3'UTR|TCL6_uc001yet.1_Missense_Mutation_p.D21N|TCL6_uc001yeu.2_3'UTR|TCL6_uc001yev.2_3'UTR|TCL1B_uc001yew.2_RNA|TCL1B_uc001yex.2_RNA|TCL1B_uc010avj.2_Intron|TCL6_uc010avk.1_5'Flank	NM_020554	NP_065579			SubName: Full=T-cell leukemia/lymphoma 6 ORF163;												0		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		aaggagaggggaccatgcaaa	0.005			NA	T	TRA@	T-ALL								10	19					0	0	0.001855	0	0
ATG2B	55102	broad.mit.edu	37	14	96769497	96769497	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:96769497C>A	uc001yfi.2	-	33	5303	c.4938G>T	c.(4936-4938)CAG>CAT	p.Q1646H		NM_018036	NP_060506	Q96BY7	ATG2B_HUMAN	ATG2 autophagy related 2 homolog B	1646										ovary(1)|kidney(1)|skin(1)	3		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		TCTCAAGATCCTGAACAATGA	0.433			NA											14	21					0.000151284	0.000161292	0.001855	1	0
BCL11B	64919	broad.mit.edu	37	14	99640777	99640777	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:99640777T>A	uc001yga.2	-	4	2663	c.2396A>T	c.(2395-2397)GAG>GTG	p.E799V	BCL11B_uc001ygb.2_Missense_Mutation_p.E728V	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	799	C2H2-type 4.					nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GCCGCAGTACTCGCACGTGTC	0.597			NA	T	TLX3	T-ALL								4	15					0	0	0.001168	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102469237	102469237	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:102469237C>A	uc001yks.2	+	23	4982	c.4818C>A	c.(4816-4818)GAC>GAA	p.D1606E		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1606	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						GATTGGCAGACCTGCTAGGAA	0.463			NA											26	21					5.45024e-15	7.30982e-15	0.00333	1	0
CDC42BPB	9578	broad.mit.edu	37	14	103405971	103405971	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:103405971C>A	uc001ymi.1	-	34	5035	c.4803G>T	c.(4801-4803)ATG>ATT	p.M1601I		NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1601					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGAGCACCTGCATGCCGTCGC	0.617			NA											30	16					3.65163e-15	4.918e-15	0.00632	1	0
KIAA0284	283638	broad.mit.edu	37	14	105353375	105353377	+	Missense_Mutation	TNP	GGA	GGA	TAC			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GGA	GGA	-	-	GGA	GGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:105353375_105353377GGA>TAC	uc010axb.2	+	12	3023_3025	c.2799_2801GGA>TAC	c.(2797-2802)GTGGAT>GTTACT	p.D934T	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.D864T|KIAA0284_uc001yps.2_Missense_Mutation_p.D840T|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	934						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		CTAATTCTGTGGATGCCGAGTGT	0.675			NA											7	13					0	0	0.004672	0	0
KIAA0284	283638	broad.mit.edu	37	14	105353403	105353403	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:105353403C>T	uc010axb.2	+	12	3051	c.2827C>T	c.(2827-2829)CCG>TCG	p.P943S	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_Missense_Mutation_p.P873S|KIAA0284_uc001yps.2_Missense_Mutation_p.P849S|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	943						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GGGCAGCACCCCGAGGCCGCC	0.687			NA											11	14					0	0	0.002299	0	0
CRIP2	1397	broad.mit.edu	37	14	105945464	105945464	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:105945464G>A	uc001yrd.1	+	6	478	c.409G>A	c.(409-411)GAG>AAG	p.E137K	CRIP2_uc010tyr.1_Missense_Mutation_p.E211K|CRIP2_uc001yre.1_Missense_Mutation_p.E137K|CRIP2_uc001yrf.1_RNA|CRIP2_uc001yrg.2_RNA|CRIP2_uc001yrh.1_RNA	NM_001312	NP_001303	P52943	CRIP2_HUMAN	cysteine-rich protein 2	137	LIM zinc-binding 2.						zinc ion binding				0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.235)		CTTTCCAGCTGAGAAGGTGAC	0.627			NA											17	5					0	0	0.007413	0	0
Unknown	0	broad.mit.edu	37	15	20645832	20645832	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:20645832G>A	uc001ytg.2	-	20	2953	c.2244C>T	c.(2242-2244)CTC>CTT	p.L748L	uc010tyx.1_RNA|uc001yth.3_Silent_p.L748L|uc010tyy.1_Silent_p.L748L					RecName: Full=Putative HERC2-like protein 3;												NA						CCTGCAGCGTGAGAGCGATGC	0.617			NA											9	40					0	0	0.004482	0	0
CXADRP2	646243	broad.mit.edu	37	15	22016402	22016402	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:22016402C>A	uc010tzk.1	-	1	477	c.315G>T	c.(313-315)AAG>AAT	p.K105N		NR_024387				RecName: Full=Coxsackievirus and adenovirus receptor; AltName: Full=Coxsackievirus B-adenovirus receptor; AltName: Full=HCVADR;          Short=hCAR; AltName: Full=CVB3-binding protein; Flags: Precursor;												0						CCAGCTGAATCTTCCTATTTG	0.378			NA											5	40					4.096e-09	4.8869e-09	0.001168	1	0
OR4N4	283694	broad.mit.edu	37	15	22383042	22383042	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:22383042C>A	uc001yuc.1	+	7	1551	c.570C>A	c.(568-570)ACC>ACA	p.T190T	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Silent_p.T190T	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	190	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TGGCTTGCACCGACATGTTTG	0.527			NA											16	23					7.41877e-09	8.79241e-09	0.001882	1	0
OR4N3P	390539	broad.mit.edu	37	15	22413817	22413818	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:22413817_22413818CC>AA	uc001yuf.2	+	1	116_117	c.116_117CC>AA	c.(115-117)GCC>GAA	p.A39E		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						GTTGTGATGGCCTTTGACCGCT	0.5			NA											40	80					0	0	0.004672	0	0
C15orf2	23742	broad.mit.edu	37	15	24921679	24921679	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:24921679G>T	uc001ywo.2	+	1	1139	c.665G>T	c.(664-666)AGT>ATT	p.S222I		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	222					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		AACAGCATGAGTGAGAAGGCC	0.617			NA											18	13					2.35188e-11	2.94594e-11	0.006122	1	0
C15orf2	23742	broad.mit.edu	37	15	24923130	24923130	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:24923130T>A	uc001ywo.2	+	1	2590	c.2116T>A	c.(2116-2118)TCC>ACC	p.S706T		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	706					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		CACTCCTCCTTCCAAGGCTGT	0.512			NA											60	143					0	0	0.00361	0	0
C15orf2	23742	broad.mit.edu	37	15	24923596	24923596	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:24923596T>A	uc001ywo.2	+	1	3056	c.2582T>A	c.(2581-2583)CTA>CAA	p.L861Q		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	861					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GGGAACACACTACACAGTGAC	0.493			NA											47	59					0	0	0.002522	0	0
C15orf2	23742	broad.mit.edu	37	15	24923752	24923752	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:24923752C>G	uc001ywo.2	+	1	3212	c.2738C>G	c.(2737-2739)TCT>TGT	p.S913C		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	913					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TCTGACAGTTCTTTTATTCTG	0.488			NA											84	73					0	0	0.00361	0	0
HERC2	8924	broad.mit.edu	37	15	28380792	28380792	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:28380792C>A	uc001zbj.2	-	79	12168	c.12062G>T	c.(12061-12063)GGG>GTG	p.G4021V		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4021	RCC1 14.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGACTCTGTCCCTCCAATGCC	0.448			NA											64	95					3.30712e-30	5.51376e-30	0.00361	1	0
HERC2	8924	broad.mit.edu	37	15	28391471	28391471	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:28391471T>A	uc001zbj.2	-	71	11026	c.10920A>T	c.(10918-10920)GTA>GTT	p.V3640V		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3640					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGTCAAATTCTACCCTGAGTC	0.527			NA											51	80					0	0	0.00361	0	0
HERC2	8924	broad.mit.edu	37	15	28413635	28413635	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:28413635C>A	uc001zbj.2	-	67	10437	c.10331G>T	c.(10330-10332)AGT>ATT	p.S3444I		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	3444					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		ATTCATGGGACTAGCCATCGC	0.562			NA											78	134					9.35349e-44	1.67652e-43	0.00361	1	0
HERC2	8924	broad.mit.edu	37	15	28465739	28465739	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:28465739C>A	uc001zbj.2	-	37	5810	c.5704G>T	c.(5704-5706)GGA>TGA	p.G1902*		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1902	MIB/HERC2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CTTATCCATCCGTCCTCTCCC	0.577			NA											73	145					3.25985e-27	5.29349e-27	0.00361	1	0
HERC2	8924	broad.mit.edu	37	15	28510997	28510997	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:28510997G>A	uc001zbj.2	-	13	1828	c.1722C>T	c.(1720-1722)ACC>ACT	p.T574T	HERC2_uc001zbl.1_Silent_p.T269T	NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	574	RCC1 2.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGCGGCCCCAGGTGTACAGCT	0.632			NA											34	59					0	0	0.003755	0	0
APBA2	321	broad.mit.edu	37	15	29346822	29346822	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:29346822C>T	uc001zck.2	+	3	942	c.735C>T	c.(733-735)GCC>GCT	p.A245A	APBA2_uc010azj.2_Silent_p.A245A|APBA2_uc010uat.1_Silent_p.A245A|APBA2_uc001zcl.2_Silent_p.A245A|APBA2_uc010uas.1_Silent_p.A245A	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	245	STXBP1-binding.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TCACCAGCGCCAGTGAGGCCA	0.642			NA											68	42					0	0	0.00361	0	0
APBA2	321	broad.mit.edu	37	15	29346929	29346929	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:29346929C>A	uc001zck.2	+	3	1049	c.842C>A	c.(841-843)CCC>CAC	p.P281H	APBA2_uc010azj.2_Missense_Mutation_p.P281H|APBA2_uc010uat.1_Missense_Mutation_p.P281H|APBA2_uc001zcl.2_Missense_Mutation_p.P281H|APBA2_uc010uas.1_Missense_Mutation_p.P281H	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	281					nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GAGGCGAGGCCCAAGTCGCTG	0.677			NA											63	38					9.40535e-28	1.53631e-27	0.00361	1	0
APBA2	321	broad.mit.edu	37	15	29406125	29406125	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:29406125G>T	uc001zck.2	+	13	2291	c.2084G>T	c.(2083-2085)CGT>CTT	p.R695L	APBA2_uc010uat.1_Missense_Mutation_p.R683L|APBA2_uc001zcl.2_Missense_Mutation_p.R683L	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	695	PDZ 2.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GGGGGCGTCCGTGTGGGCCAC	0.627			NA											29	119					1.39806e-14	1.85576e-14	0.008361	1	0
TRPM1	4308	broad.mit.edu	37	15	31294182	31294182	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:31294182C>G	uc001zfm.2	-	27	4783	c.4655G>C	c.(4654-4656)AGT>ACT	p.S1552T	TRPM1_uc010azy.2_Missense_Mutation_p.S1459T|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	1552	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TCCATGTAAACTTTTTGACCT	0.428			NA											75	15					0	0	0.00361	0	0
RYR3	6263	broad.mit.edu	37	15	33822819	33822819	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:33822819C>A	uc001zhi.2	+	4	376	c.306C>A	c.(304-306)ACC>ACA	p.T102T	RYR3_uc010bar.2_Silent_p.T102T	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	102	Cytoplasmic (By similarity).|MIR 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCCACAGGACCCTGTTATACG	0.512			NA											8	7					2.17888e-05	2.37539e-05	0.006214	1	0
RYR3	6263	broad.mit.edu	37	15	34105127	34105127	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:34105127C>T	uc001zhi.2	+	73	10391	c.10321C>T	c.(10321-10323)CCT>TCT	p.P3441S	RYR3_uc010bar.2_Missense_Mutation_p.P3436S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3441					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GAGTGAAGAACCTTTCAATCC	0.458			NA											36	4					0	0	0.004878	0	0
AQR	9716	broad.mit.edu	37	15	35224619	35224619	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:35224619C>A	uc001ziv.2	-	11	981	c.800G>T	c.(799-801)AGG>ATG	p.R267M		NM_014691	NP_055506	O60306	AQR_HUMAN	aquarius	267						catalytic step 2 spliceosome	RNA binding			large_intestine(1)	1		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		AAACCAGCGCCTTGTGGGTAG	0.428			NA											18	26					2.94398e-08	3.44236e-08	0.007413	1	0
C15orf41	84529	broad.mit.edu	37	15	37001480	37001480	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:37001480G>T	uc001zje.3	+	9	851	c.601G>T	c.(601-603)GTA>TTA	p.V201L	C15orf41_uc001zjd.2_Missense_Mutation_p.V201L|C15orf41_uc010bbb.1_Missense_Mutation_p.V103L|C15orf41_uc001zjf.2_Missense_Mutation_p.V103L|C15orf41_uc010uci.1_Missense_Mutation_p.V103L	NM_001130010	NP_001123482	Q9Y2V0	CO041_HUMAN	hypothetical protein LOC84529 isoform 1	201							protein binding			pancreas(1)	1		all_epithelial(112;3.06e-10)|Lung NSC(122;6.48e-08)|all_lung(180;8.31e-07)|Melanoma(134;0.222)		all cancers(64;1.76e-19)|GBM - Glioblastoma multiforme(113;5.03e-07)|BRCA - Breast invasive adenocarcinoma(123;0.11)		CATTTTACAAGTACCAGTTGG	0.264			NA											8	2					4.68919e-08	5.45661e-08	0.008291	1	0
C15orf23	90417	broad.mit.edu	37	15	40675071	40675071	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:40675071T>G	uc001zll.2	+	1	150	c.35T>G	c.(34-36)GTT>GGT	p.V12G	C15orf23_uc010ucp.1_Missense_Mutation_p.V12G|C15orf23_uc001zlo.2_Missense_Mutation_p.V12G|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	12						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		CTGGACAGAGTTTTCCGTACA	0.592			NA											20	5					0	0	0.008871	0	0
C15orf23	90417	broad.mit.edu	37	15	40675205	40675205	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:40675205G>T	uc001zll.2	+	1	284	c.169G>T	c.(169-171)GAG>TAG	p.E57*	C15orf23_uc010ucp.1_Nonsense_Mutation_p.E57*|C15orf23_uc001zlo.2_Nonsense_Mutation_p.E57*|C15orf23_uc001zlm.2_RNA|C15orf23_uc001zln.2_RNA	NM_033286	NP_150628	Q9Y448	T4AF1_HUMAN	TRAF4 associated factor 1 isoform a	57						nucleus	protein binding			ovary(1)|skin(1)	2		all_cancers(109;2.34e-14)|all_epithelial(112;9.21e-12)|Lung NSC(122;2.95e-09)|all_lung(180;6.03e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.39e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0798)		TCTTTTAAACGAGAGCGAGAA	0.622			NA											41	19					1.89013e-27	3.07702e-27	0.00361	1	0
DLL4	54567	broad.mit.edu	37	15	41228552	41228552	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:41228552A>G	uc001zng.1	+	9	1687	c.1367A>G	c.(1366-1368)CAT>CGT	p.H456R		NM_019074	NP_061947	Q9NR61	DLL4_HUMAN	delta-like 4 protein precursor	456	EGF-like 7.|Extracellular (Potential).				blood circulation|cell communication|cell differentiation|Notch receptor processing|Notch signaling pathway	integral to membrane|plasma membrane	calcium ion binding|Notch binding			breast(2)	2		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GGCACTTGCCATGACCTGGAG	0.642			NA											10	0					0	0	0.006214	0	0
CDAN1	146059	broad.mit.edu	37	15	43017718	43017718	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:43017718A>G	uc001zql.2	-	26	3536	c.3419T>C	c.(3418-3420)GTG>GCG	p.V1140A	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Missense_Mutation_p.V466A	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	1140						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CAGAAGCCCCACATTTCTTGG	0.572			NA											61	9					0	0	0.00361	0	0
CDAN1	146059	broad.mit.edu	37	15	43028533	43028533	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:43028533G>A	uc001zql.2	-	2	653	c.536C>T	c.(535-537)CCT>CTT	p.P179L	CDAN1_uc001zqk.2_5'Flank|CDAN1_uc010bcx.1_5'Flank|uc001zqm.2_5'Flank	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	179						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GCCTACGGGAGGGAACTCCTC	0.667			NA											21	7					0	0	0.005443	0	0
CATSPER2	117155	broad.mit.edu	37	15	43939616	43939616	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:43939616C>A	uc001zsh.2	-	3	410	c.195G>T	c.(193-195)GTG>GTT	p.V65V	CATSPER2_uc010bdm.2_RNA|CATSPER2_uc001zsi.2_Silent_p.V65V|CATSPER2_uc001zsj.2_Silent_p.V65V|CATSPER2_uc001zsk.2_Silent_p.V65V|CATSPER2_uc001zsl.1_RNA	NM_172095	NP_742093	Q96P56	CTSR2_HUMAN	sperm-associated cation channel 2 isoform 2	65	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|protein binding|voltage-gated ion channel activity			ovary(1)	1		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TAGAGAAACGCACTAGCTGGT	0.438			NA											74	13					5.04879e-28	8.27488e-28	0.00361	1	0
TRIM69	140691	broad.mit.edu	37	15	45028906	45028906	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:45028906G>C	uc001zuf.2	+	2	899	c.4G>C	c.(4-6)GAG>CAG	p.E2Q	TRIM69_uc001zui.1_5'UTR|TRIM69_uc010bdy.1_5'UTR|TRIM69_uc001zug.1_Missense_Mutation_p.E2Q|TRIM69_uc001zuh.1_Missense_Mutation_p.E2Q	NM_182985	NP_892030	Q86WT6	TRI69_HUMAN	tripartite motif-containing 69 isoform a	2	Necessary for nuclear localization (By similarity).				apoptosis	nuclear speck	zinc ion binding				0		all_cancers(109;2.47e-13)|all_epithelial(112;2.84e-11)|Lung NSC(122;2.23e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;5.5e-19)|GBM - Glioblastoma multiforme(94;1.07e-06)|Colorectal(105;0.138)|COAD - Colon adenocarcinoma(120;0.141)		AAGCTTCATGGAGGTGAGTGA	0.483	Pancreas(84;519 1450 1802 20427 34706)		NA											15	4					0	0	0.003163	0	0
TRPM7	54822	broad.mit.edu	37	15	50905990	50905990	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:50905990G>A	uc001zyt.3	-	15	1948	c.1684C>T	c.(1684-1686)CAT>TAT	p.H562Y	TRPM7_uc010bew.1_Missense_Mutation_p.H562Y|TRPM7_uc001zyu.2_Missense_Mutation_p.H120Y	NM_017672	NP_060142	Q96QT4	TRPM7_HUMAN	transient receptor potential cation channel,	562	Cytoplasmic (Potential).				cell death	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein serine/threonine kinase activity			ovary(4)|stomach(3)|breast(1)|central_nervous_system(1)|skin(1)	10				all cancers(107;0.000819)|GBM - Glioblastoma multiforme(94;0.0045)		AAAGATTCATGACTCTTTCGC	0.383			NA											7	18					0	0	0.004482	0	0
GNB5	10681	broad.mit.edu	37	15	52420406	52420406	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:52420406G>A	uc002abt.1	-	10	964	c.899C>T	c.(898-900)TCA>TTA	p.S300L	GNB5_uc002abr.1_Missense_Mutation_p.S258L|GNB5_uc002abs.1_Missense_Mutation_p.S188L	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	300	WD 5.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		AGCGTCATCTGACCCTGAAGC	0.423			NA											23	12					0	0	0.007291	0	0
UNC13C	440279	broad.mit.edu	37	15	54306850	54306850	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:54306850C>A	uc002ack.2	+	1	1750	c.1750C>A	c.(1750-1752)CGG>AGG	p.R584R		NM_001080534	NP_001074003	Q8NB66	UN13C_HUMAN	unc-13 homolog C	584					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			ovary(5)|pancreas(2)	7				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		ATCTTCGGACCGGGAGCTATG	0.453			NA											18	7					5.01169e-05	5.42396e-05	0.00499	1	0
RFX7	64864	broad.mit.edu	37	15	56387748	56387748	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:56387748T>C	uc010bfn.2	-	9	2178	c.2178A>G	c.(2176-2178)ATA>ATG	p.I726M	RFX7_uc010ugk.1_RNA|RFX7_uc002adn.1_Missense_Mutation_p.I540M	NM_022841	NP_073752	Q2KHR2	RFX7_HUMAN	regulatory factor X domain containing 2	629					regulation of transcription, DNA-dependent	nucleus	DNA binding				0						GATTTGCTCCTATGTGTGAAC	0.413			NA											19	11					0	0	0.007413	0	0
FAM63B	54629	broad.mit.edu	37	15	59102480	59102480	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:59102480G>A	uc002afj.2	+	4	1217	c.1015G>A	c.(1015-1017)GTA>ATA	p.V339I	FAM63B_uc002afi.2_Missense_Mutation_p.V339I|FAM63B_uc002afk.2_RNA|FAM63B_uc002afl.2_RNA	NM_001040450	NP_001035540	Q8NBR6	FA63B_HUMAN	hypothetical protein LOC54629 isoform a	339										central_nervous_system(1)	1						AGGCCTGGATGTAAATGTAAG	0.368			NA											18	13					0	0	0.002299	0	0
PML	5371	broad.mit.edu	37	15	74315359	74315359	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:74315359G>T	uc002awv.2	+	3	933	c.793G>T	c.(793-795)GTC>TTC	p.V265F	PML_uc002awm.2_Missense_Mutation_p.V265F|PML_uc002awl.2_Missense_Mutation_p.V265F|PML_uc002awj.1_Missense_Mutation_p.V265F|PML_uc002awk.2_Missense_Mutation_p.V265F|PML_uc002awn.2_Missense_Mutation_p.V265F|PML_uc002awo.2_Missense_Mutation_p.V265F|PML_uc002awp.2_Missense_Mutation_p.V265F|PML_uc002awq.2_Missense_Mutation_p.V265F|PML_uc002awr.2_Missense_Mutation_p.V265F|PML_uc002aws.2_Missense_Mutation_p.V265F|PML_uc002awt.2_Missense_Mutation_p.V265F|PML_uc002awu.2_Missense_Mutation_p.V265F|PML_uc010ule.1_Intron|PML_uc002aww.1_Missense_Mutation_p.V180F|PML_uc002awx.2_Missense_Mutation_p.V23F|PML_uc002awy.2_5'Flank	NM_033238	NP_150241	P29590	PML_HUMAN	promyelocytic leukemia protein isoform 1	265					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding|zinc ion binding			central_nervous_system(2)|kidney(2)|breast(1)	5						GCACGCGGCCGTCGGCCAGCT	0.701			NA	T	RARA|PAX5	APL|ALL								18	5					1.67942e-08	1.97446e-08	0.006122	1	0
ISLR2	57611	broad.mit.edu	37	15	74426880	74426880	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:74426880A>T	uc002axd.2	+	4	2554	c.1785A>T	c.(1783-1785)GCA>GCT	p.A595A	ISLR2_uc002axe.2_Silent_p.A595A|ISLR2_uc010bjg.2_Silent_p.A595A|ISLR2_uc010bjf.2_Silent_p.A595A	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	595	Helical; (Potential).				positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						TCATAGTGGCAGTGAGCGTAT	0.632			NA									OREG0023277	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	8					0	0	0.004878	0	0
CSPG4	1464	broad.mit.edu	37	15	75977804	75977804	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:75977804G>T	uc002baw.2	-	4	4121	c.4028C>A	c.(4027-4029)CCC>CAC	p.P1343H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	1343	Interaction with COL5A1 (By similarity).|Extracellular (Potential).|Gly/Ser-rich (glycosaminoglycan attachment domain).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						GCCCTCGAGGGGAGCACCCAG	0.672			NA											18	5					2.4624e-09	2.94878e-09	0.008871	1	0
IL16	3603	broad.mit.edu	37	15	81578048	81578048	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:81578048C>A	uc002bgh.3	+	10	1585	c.1209C>A	c.(1207-1209)GAC>GAA	p.D403E	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.D403E|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.D445E|IL16_uc002bgg.2_Missense_Mutation_p.D403E|IL16_uc002bgi.1_5'UTR	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	403	PDZ 2.|Interaction with GRIN2A.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			ovary(2)|lung(1)|skin(1)	4						GGTGTGGGGACGAGATTGTGG	0.527			NA											40	17					1.60099e-16	2.20692e-16	0.004878	1	0
BNC1	646	broad.mit.edu	37	15	83926531	83926531	+	Missense_Mutation	SNP	C	C	A	rs138195790		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:83926531C>A	uc002bjt.1	-	5	2736	c.2648G>T	c.(2647-2649)GGC>GTC	p.G883V	BNC1_uc010uos.1_Missense_Mutation_p.G871V	NM_001717	NP_001708	Q01954	BNC1_HUMAN	basonuclin 1	883					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAGCACAGTGCCTTCCTCACT	0.552			NA											91	22					1.52223e-32	2.58472e-32	0.00361	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611740	84611740	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:84611740C>A	uc002bjz.3	+	19	2620	c.2396C>A	c.(2395-2397)TCA>TAA	p.S799*	ADAMTSL3_uc010bmt.1_Nonsense_Mutation_p.S799*|ADAMTSL3_uc010bmu.1_Nonsense_Mutation_p.S799*	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	799	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TTGAATCTCTCAGATGAATTG	0.522			NA											15	13					1.3612e-06	1.52348e-06	0.003163	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84639249	84639249	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:84639249G>T	uc002bjz.3	+	20	2728	c.2504G>T	c.(2503-2505)TGT>TTT	p.C835F	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.C835F|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.C835F	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	835	TSP type-1 7.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			TCTGTCAGTTGTGGTGTTGGA	0.517			NA											74	20					2.32478e-39	4.09483e-39	0.00361	1	0
AGBL1	123624	broad.mit.edu	37	15	86686992	86686992	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:86686992C>A	uc002blz.1	+	2	120	c.40C>A	c.(40-42)CTG>ATG	p.L14M		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	14					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						TCTGCAGACCCTGGTAGACAC	0.542			NA											44	6					1.61863e-15	2.19525e-15	0.00361	1	0
HAPLN3	145864	broad.mit.edu	37	15	89421289	89421289	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:89421289C>A	uc002bnc.2	-	5	1123	c.995G>T	c.(994-996)TGT>TTT	p.C332F	HAPLN3_uc002bne.2_RNA|HAPLN3_uc002bnd.2_Missense_Mutation_p.C394F	NM_178232	NP_839946	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	332	Link 2.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding				0	Lung NSC(78;0.0392)|all_lung(78;0.077)					TGGGGGCCCACAGTTAGGATG	0.652			NA											74	23					9.63364e-24	1.50133e-23	0.00361	1	0
RHBDF1	64285	broad.mit.edu	37	16	113013	113013	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:113013C>A	uc002cfl.3	-	8	778	c.630G>T	c.(628-630)TCG>TCT	p.S210S	RHBDF1_uc010uty.1_Silent_p.S233S|RHBDF1_uc010utz.1_Silent_p.S210S|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	210	Cytoplasmic (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				TCTTGGCCACCGACTCTCGCT	0.701			NA											13	11					1.15088e-07	1.32252e-07	0.004007	1	0
SOX8	30812	broad.mit.edu	37	16	1035161	1035161	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:1035161C>A	uc002ckn.2	+	3	1231	c.1116C>A	c.(1114-1116)CCC>CCA	p.P372P		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	372					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				cggccgcccccgccggccccT	0.612			NA											8	18					0.00307968	0.00318168	0.00308	1	0
E4F1	1877	broad.mit.edu	37	16	2284322	2284322	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:2284322A>T	uc002cpm.2	+	10	1574	c.1526A>T	c.(1525-1527)CAC>CTC	p.H509L	E4F1_uc010bsi.2_Missense_Mutation_p.H509L|E4F1_uc010bsj.2_Intron|DNASE1L2_uc002cpn.2_5'Flank|DNASE1L2_uc002cpo.2_5'Flank|DNASE1L2_uc002cpp.2_5'Flank|DNASE1L2_uc002cpq.2_5'Flank	NM_004424	NP_004415	Q66K89	E4F1_HUMAN	p120E4F	509	Mediates interaction with CDKN2A.|Interaction with BMI1.|C2H2-type 6.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GTGCGTGGCCACCGGCGCGTC	0.642			NA											19	25					0	0	0.007413	0	0
CREBBP	1387	broad.mit.edu	37	16	3900688	3900688	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:3900688C>A	uc002cvv.2	-	2	612	c.408G>T	c.(406-408)CAG>CAT	p.Q136H	CREBBP_uc002cvw.2_Missense_Mutation_p.Q136H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	136					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGCTGGCTGCCTGTTTAGGCA	0.632			NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybsyndrome				36	43					1.57351e-24	2.47614e-24	0.003755	1	0
CORO7	79585	broad.mit.edu	37	16	4411088	4411088	+	Splice_Site	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:4411088T>A	uc002cwh.3	-	19	1895	c.1775_splice	c.e19-1	p.G592_splice	CORO7_uc002cwe.2_Splice_Site|CORO7_uc002cwf.2_Splice_Site_p.G592_splice|CORO7_uc002cwg.3_Splice_Site_p.G372_splice|CORO7_uc010uxh.1_Splice_Site_p.G574_splice|CORO7_uc010uxi.1_Splice_Site_p.G507_splice|CORO7_uc002cwi.1_Splice_Site_p.G372_splice|CORO7_uc010uxj.1_Splice_Site	NM_024535	NP_078811	P57737	CORO7_HUMAN	coronin 7							cytoplasmic membrane-bounded vesicle|cytosol|Golgi membrane|integral to membrane of membrane fraction|soluble fraction					0						CCGTGTGGCCTGGAGGAAGGC	0.627			NA											9	24					0	0	0.004482	0	0
UBN1	29855	broad.mit.edu	37	16	4924437	4924437	+	Missense_Mutation	SNP	G	G	T	rs150281333		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:4924437G>T	uc002cyb.2	+	15	2365	c.2026G>T	c.(2026-2028)GTG>TTG	p.V676L	UBN1_uc010uxw.1_Missense_Mutation_p.V676L|UBN1_uc002cyc.2_Missense_Mutation_p.V676L	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	676					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GGTGGAAGCCGTGTCCAAGGA	0.547			NA											57	74					3.40343e-31	5.72866e-31	0.00361	1	0
A2BP1	54715	broad.mit.edu	37	16	7703943	7703943	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:7703943A>G	uc002cys.2	+	12	1872	c.884A>G	c.(883-885)TAC>TGC	p.Y295C	A2BP1_uc010buf.1_Missense_Mutation_p.Y295C|A2BP1_uc002cyr.1_Missense_Mutation_p.Y294C|A2BP1_uc002cyt.2_Missense_Mutation_p.Y268C|A2BP1_uc010uxz.1_Missense_Mutation_p.Y338C|A2BP1_uc010uya.1_Missense_Mutation_p.Y252C|A2BP1_uc002cyv.1_Missense_Mutation_p.Y295C|A2BP1_uc010uyb.1_Missense_Mutation_p.Y295C|A2BP1_uc002cyw.2_Missense_Mutation_p.Y315C|A2BP1_uc002cyy.2_Missense_Mutation_p.Y315C|A2BP1_uc002cyx.2_Missense_Mutation_p.Y315C|A2BP1_uc010uyc.1_Missense_Mutation_p.Y288C	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	295					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		ATCCCGGCCTACGGCGGGTAA	0.617			NA											5	8					0	0	0.000602	0	0
C16orf68	79091	broad.mit.edu	37	16	8722679	8722679	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:8722679G>T	uc002cyz.2	+	3	502	c.226G>T	c.(226-228)GAG>TAG	p.E76*	C16orf68_uc002cza.2_Nonsense_Mutation_p.E76*	NM_024109	NP_077014	Q9BUU2	MET22_HUMAN	hypothetical protein LOC79091	76							methyltransferase activity				0						TCACACAAAGGAGCCTCCTTC	0.552			NA											14	39					2.23348e-06	2.47965e-06	0.004007	1	0
C16orf68	79091	broad.mit.edu	37	16	8722940	8722940	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:8722940G>C	uc002cyz.2	+	3	763	c.487G>C	c.(487-489)GGC>CGC	p.G163R	C16orf68_uc002cza.2_Missense_Mutation_p.G107R	NM_024109	NP_077014	Q9BUU2	MET22_HUMAN	hypothetical protein LOC79091	163							methyltransferase activity				0						GGAAGCACAAGGCAGCCCGCA	0.547			NA											62	140					0	0	0.00361	0	0
KIAA0430	9665	broad.mit.edu	37	16	15715643	15715643	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:15715643C>A	uc002ddr.2	-	12	2779	c.2586G>T	c.(2584-2586)AAG>AAT	p.K862N	KIAA0430_uc002ddq.2_Missense_Mutation_p.K696N|KIAA0430_uc010uzv.1_Missense_Mutation_p.K858N|KIAA0430_uc010uzw.1_Missense_Mutation_p.K861N	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	861	RRM.					peroxisome	nucleotide binding|RNA binding				0						AGACCAGGATCTTTTTGCTGC	0.428			NA											14	27					2.31682e-05	2.52152e-05	0.003163	1	0
ABCC1	4363	broad.mit.edu	37	16	16146667	16146667	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:16146667G>T	uc010bvi.2	+	11	1642	c.1467G>T	c.(1465-1467)ACG>ACT	p.T489T	ABCC1_uc010bvj.2_Silent_p.T489T|ABCC1_uc010bvk.2_Silent_p.T489T|ABCC1_uc010bvl.2_Silent_p.T489T|ABCC1_uc010bvm.2_Silent_p.T489T|ABCC1_uc002del.3_Silent_p.T373T|ABCC1_uc010bvn.2_Silent_p.T352T	NM_004996	NP_004987	P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C, member 1	489	Cytoplasmic.|ABC transmembrane type-1 1.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)	4					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	AGACCAAGACGTATCAGGTAA	0.582			NA											42	62					5.20006e-24	8.13666e-24	0.002852	1	0
ABCC6P1	653190	broad.mit.edu	37	16	18602570	18602570	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:18602570G>T	uc002dfg.2	+	8	968	c.768G>T	c.(766-768)CTG>CTT	p.L256L	ABCC6P1_uc010vam.1_Silent_p.L199L	NR_003569				SubName: Full=cDNA FLJ51267, highly similar to Multidrug resistance-associated protein 6;												0						CCTTCCTCCTGGGGACCCTCA	0.597			NA											32	49					1.26612e-14	1.68409e-14	0.003271	1	0
UMOD	7369	broad.mit.edu	37	16	20355356	20355356	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:20355356G>T	uc002dgz.2	-	6	1450	c.1321C>A	c.(1321-1323)CCA>ACA	p.P441T	UMOD_uc002dha.2_Missense_Mutation_p.P441T|UMOD_uc002dhb.2_Missense_Mutation_p.P474T	NM_003361	NP_003352	P07911	UROM_HUMAN	uromodulin precursor	441	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			ovary(1)|skin(1)	2						CTGACCATTGGCTGTAGGGCG	0.547			NA											21	27					1.50039e-11	1.88181e-11	0.001882	1	0
PDILT	204474	broad.mit.edu	37	16	20376864	20376864	+	Splice_Site	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:20376864T>C	uc002dhc.1	-	9	1340	c.1117_splice	c.e9-1	p.K373_splice		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis						cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						TTGATGTTTCTAGGAAGCACA	0.448			NA											36	53					0	0	0.00874	0	0
ACSM2A	123876	broad.mit.edu	37	16	20486999	20486999	+	Nonsense_Mutation	SNP	C	C	A	rs145558453	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:20486999C>A	uc010bwe.2	+	9	1241	c.1002C>A	c.(1000-1002)TGC>TGA	p.C334*	ACSM2A_uc010vax.1_Nonsense_Mutation_p.C255*|ACSM2A_uc002dhf.3_Nonsense_Mutation_p.C334*|ACSM2A_uc002dhg.3_Nonsense_Mutation_p.C334*|ACSM2A_uc010vay.1_Nonsense_Mutation_p.C255*|ACSM2A_uc002dhh.3_5'UTR	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	334					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						TACAGAACTGCGTCACTGTAG	0.517			NA											49	84					1.30916e-28	2.16034e-28	0.00361	1	0
DNAH3	55567	broad.mit.edu	37	16	21133343	21133343	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:21133343G>A	uc010vbe.1	-	10	1507	c.1507C>T	c.(1507-1509)CCA>TCA	p.P503S	DNAH3_uc002die.2_Missense_Mutation_p.P474S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	503	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TCAAAAGATGGATTGAAGACA	0.378			NA											21	17					0	0	0.010504	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261441	21261441	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:21261441C>A	uc010bwp.1	+	2	597	c.554C>A	c.(553-555)CCT>CAT	p.P185H	CRYM_uc010bwq.1_Intron	NM_145865	NP_665872	Q8N8V4	ANS4B_HUMAN	harmonin-interacting ankyrin-repeat containing	185										ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0565)		AGATCATCCCCTTCAAATGCT	0.473			NA											22	36					1.22574e-08	1.44812e-08	0.002299	1	0
IL21R	50615	broad.mit.edu	37	16	27456035	27456035	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:27456035C>A	uc002doq.1	+	6	913	c.680C>A	c.(679-681)TCA>TAA	p.S227*	IL21R_uc002dor.1_Nonsense_Mutation_p.S227*|IL21R_uc002dos.1_Nonsense_Mutation_p.S227*	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	227	Extracellular (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						CAGACCCAGTCAGAGGGTAGG	0.582			NA	T	BCL6	NHL								17	40					3.32936e-07	3.78318e-07	0.006122	1	0
GTF3C1	2975	broad.mit.edu	37	16	27476583	27476583	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:27476583G>T	uc002dov.1	-	33	5393	c.5353C>A	c.(5353-5355)CAG>AAG	p.Q1785K	GTF3C1_uc002dou.2_Missense_Mutation_p.Q1785K	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1785						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CAGCTCACCTGGATGCAATCT	0.572			NA											21	39					3.5997e-14	4.7295e-14	0.002299	1	0
GTF3C1	2975	broad.mit.edu	37	16	27497373	27497373	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:27497373T>A	uc002dov.1	-	24	3843	c.3803A>T	c.(3802-3804)CAG>CTG	p.Q1268L	GTF3C1_uc002dou.2_Missense_Mutation_p.Q1268L	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1268						transcription factor TFIIIC complex	DNA binding|protein binding	p.Q1268Q(1)		ovary(2)|pancreas(1)|breast(1)|skin(1)	5						CCCATCCTCCTGCATAGACCA	0.602			NA											57	71					0	0	0.00361	0	0
APOB48R	55911	broad.mit.edu	37	16	28507384	28507384	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:28507384C>T	uc002dqb.1	+	2	1032	c.1022C>T	c.(1021-1023)TCA>TTA	p.S341L	uc010vct.1_Intron|APOB48R_uc010byg.1_5'UTR	NM_018690	NP_061160	Q0VD83	APOBR_HUMAN	apolipoprotein B48 receptor	341	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle					0						GGGATAGCCTCAGGCGGGGAG	0.721			NA											10	16					0	0	0.008291	0	0
ATP2A1	487	broad.mit.edu	37	16	28909350	28909350	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:28909350C>T	uc002dro.1	+	13	1633	c.1449C>T	c.(1447-1449)TTC>TTT	p.F483F	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.F483F|ATP2A1_uc002drp.1_Silent_p.F358F	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	483	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGAAGGAATTCACCCTGGAGT	0.512			NA											46	79					0	0	0.002852	0	0
CD19	930	broad.mit.edu	37	16	28948976	28948976	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:28948976G>T	uc002drs.2	+	11	1466	c.1404G>T	c.(1402-1404)CTG>CTT	p.L468L	uc010vct.1_Intron|CD19_uc010byo.1_Silent_p.L468L	NM_001770	NP_001761	P15391	CD19_HUMAN	CD19 antigen precursor	468	Cytoplasmic (Potential).				cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			ovary(2)|central_nervous_system(1)	3						ATGAAGAGCTGACCCAGCCGG	0.572			NA											13	26					0.000219431	0.000232792	0.00245	1	0
MAPK3	5595	broad.mit.edu	37	16	30128053	30128053	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:30128053C>A	uc002dws.2	-	8	1176	c.1076G>T	c.(1075-1077)CGG>CTG	p.R359L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MAPK3_uc002dwr.2_Missense_Mutation_p.R245L|MAPK3_uc002dwv.3_Missense_Mutation_p.R315L|MAPK3_uc002dwt.2_3'UTR|MAPK3_uc002dwu.2_RNA|MAPK3_uc010bzp.2_RNA	NM_002746	NP_002737	P27361	MK03_HUMAN	mitogen-activated protein kinase 3 isoform 1	359					activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding				0					Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	CTCCTTCAGCCGCTCCTTAGG	0.642			NA											28	34					4.59853e-10	5.5864e-10	0.005443	1	0
SETD1A	9739	broad.mit.edu	37	16	30977498	30977498	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:30977498G>T	uc002ead.1	+	8	2982	c.2296G>T	c.(2296-2298)GGA>TGA	p.G766*		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	766					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CTCAGTCTCGGGAGAGGAGGC	0.677			NA											16	13					6.72482e-11	8.32105e-11	0.003163	1	0
SETD1A	9739	broad.mit.edu	37	16	30990664	30990664	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:30990664C>T	uc002ead.1	+	14	4243	c.3557C>T	c.(3556-3558)CCG>CTG	p.P1186L		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	1186	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						CCAGCCACACCGCCGCAGGCC	0.687			NA											12	29					0	0	0.003163	0	0
FUS	2521	broad.mit.edu	37	16	31196353	31196353	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:31196353G>C	uc002ebf.2	+	6	700	c.617G>C	c.(616-618)GGT>GCT	p.G206A	FUS_uc002ebe.1_Missense_Mutation_p.G202A|FUS_uc002ebh.2_Missense_Mutation_p.G205A|FUS_uc002ebg.2_Missense_Mutation_p.V13L|FUS_uc002ebi.2_Missense_Mutation_p.G206A|FUS_uc002ebj.2_Missense_Mutation_p.V13L|FUS_uc002ebk.1_5'Flank	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	206	Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		ggtggcagcggtggCTATGGA	0.214			NA	T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								8	13					0	0	0.00308	0	0
TRIM72	493829	broad.mit.edu	37	16	31230804	31230804	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:31230804G>T	uc002ebn.1	+	4	910	c.681G>T	c.(679-681)GAG>GAT	p.E227D	PYDC1_uc002ebo.2_5'Flank	NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	227					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						AGGTCCTGGAGGAGGTGGCGG	0.667			NA											15	23					0.000219431	0.000232792	0.00245	1	0
ITGAX	3687	broad.mit.edu	37	16	31382974	31382974	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:31382974T>A	uc002ebu.1	+	17	2096	c.2029T>A	c.(2029-2031)TTG>ATG	p.L677M	ITGAX_uc002ebt.2_Missense_Mutation_p.L677M	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	677	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CTCTGTGACCTTGGACCTGGC	0.637			NA											32	38					0	0	0.004289	0	0
ITGAX	3687	broad.mit.edu	37	16	31393210	31393210	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:31393210C>A	uc002ebu.1	+	30	3541	c.3474C>A	c.(3472-3474)AGC>AGA	p.S1158R	ITGAX_uc002ebt.2_Missense_Mutation_p.S1158R	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	1158	Cytoplasmic (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AGACCCCCAGCCCGCCCAGTG	0.562			NA											31	34					4.74835e-14	6.22176e-14	0.002096	1	0
ARMC5	79798	broad.mit.edu	37	16	31471207	31471207	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:31471207C>T	uc002ecc.2	+	1	891	c.362C>T	c.(361-363)CCG>CTG	p.P121L	ARMC5_uc010vfn.1_Missense_Mutation_p.P216L|ARMC5_uc010vfo.1_Missense_Mutation_p.P153L|ARMC5_uc002eca.3_Missense_Mutation_p.P121L|ARMC5_uc010vfp.1_Missense_Mutation_p.P121L|ARMC5_uc002ecb.2_Missense_Mutation_p.P121L	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	121							binding			pancreas(1)	1						AGTCCTACGCCGCCAGTGCGC	0.592			NA											11	11					0	0	0.008291	0	0
ZNF267	10308	broad.mit.edu	37	16	31926245	31926245	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:31926245G>C	uc002ecs.3	+	4	884	c.675G>C	c.(673-675)TTG>TTC	p.L225F		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	225					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AAAAAACCTTGAACCAAAGCT	0.303			NA											10	12					0	0	0.006214	0	0
Unknown	0	broad.mit.edu	37	16	33784664	33784664	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:33784664T>A	uc010vgb.1	+	2	73	c.53T>A	c.(52-54)ATC>AAC	p.I18N						RecName: Full=Transporter;												NA						GGCATCTTCATCTTCAACGTT	0.423			NA											6	26					0	0	0.001984	0	0
Unknown	0	broad.mit.edu	37	16	33784689	33784689	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:33784689G>T	uc010vgb.1	+	2	98	c.78G>T	c.(76-78)CCG>CCT	p.P26P						RecName: Full=Transporter;												NA						ACTACGAGCCGCTGGTCTACA	0.478			NA											6	30					8.12818e-05	8.70909e-05	0.001984	1	0
MYLK3	91807	broad.mit.edu	37	16	46755035	46755035	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:46755035C>A	uc002eei.3	-	9	2101	c.1985G>T	c.(1984-1986)AGG>ATG	p.R662M	MYLK3_uc010vge.1_Missense_Mutation_p.R321M	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	662	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				ACCCCCTTACCTTCTGGCCAG	0.448			NA											33	14					1.26612e-14	1.68409e-14	0.003271	1	0
ABCC12	94160	broad.mit.edu	37	16	48174658	48174658	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:48174658G>T	uc002efc.1	-	4	943	c.597C>A	c.(595-597)TCC>TCA	p.S199S	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA|ABCC12_uc002efe.1_Silent_p.S199S|ABCC12_uc010vgj.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	199	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				AAACCAAGGTGGAGAGCGCCA	0.517			NA											47	20					1.47857e-17	2.08423e-17	0.00361	1	0
ZNF423	23090	broad.mit.edu	37	16	49671721	49671721	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:49671721C>A	uc002efs.2	-	5	1640	c.1342G>T	c.(1342-1344)GAC>TAC	p.D448Y	ZNF423_uc010vgn.1_Missense_Mutation_p.D331Y	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	448	C2H2-type 10.				cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				GGCATGGAGTCCAGGCAGATC	0.567			NA											44	18					9.84934e-19	1.41942e-18	0.002522	1	0
HERPUD1	9709	broad.mit.edu	37	16	56976133	56976133	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:56976133C>T	uc002eke.1	+	7	1404	c.995C>T	c.(994-996)CCC>CTC	p.P332L	HERPUD1_uc002ekf.1_Missense_Mutation_p.P331L|HERPUD1_uc002ekg.1_Missense_Mutation_p.P307L|HERPUD1_uc010cco.1_3'UTR|HERPUD1_uc010ccp.1_Missense_Mutation_p.P234L|HERPUD1_uc002ekh.1_Missense_Mutation_p.P150L	NM_014685	NP_055500	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum	332	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	protein binding				0						AATCAGGACCCCAACAATAAC	0.512			NA	T	ERG	prostate								29	19					0	0	0.007291	0	0
GPR56	9289	broad.mit.edu	37	16	57689409	57689409	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:57689409C>T	uc002emb.2	+	7	1159	c.867C>T	c.(865-867)CTC>CTT	p.L289L	GPR56_uc002elz.1_Silent_p.L119L|GPR56_uc002ema.1_Silent_p.L114L|GPR56_uc002emc.2_Silent_p.L289L|GPR56_uc002emf.2_Silent_p.L289L|GPR56_uc010vhs.1_Silent_p.L289L|GPR56_uc002emd.2_Silent_p.L289L|GPR56_uc002eme.2_Silent_p.L289L|GPR56_uc010vht.1_Silent_p.L294L|GPR56_uc002emg.3_Silent_p.L289L|GPR56_uc010vhu.1_Silent_p.L114L	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	289	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						AGAGACTCCTCCTGGTGGACT	0.572			NA											16	7					0	0	0.007413	0	0
SLC9A5	6553	broad.mit.edu	37	16	67298304	67298304	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:67298304G>C	uc002esm.2	+	13	1955	c.1892G>C	c.(1891-1893)CGG>CCG	p.R631P	SLC9A5_uc010cee.2_Missense_Mutation_p.R336P|SLC9A5_uc010vji.1_Missense_Mutation_p.R135P	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	631					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		GCGCAGGAGCGGCAGGACAAG	0.582			NA											20	10					0	0	0.008871	0	0
GFOD2	81577	broad.mit.edu	37	16	67709088	67709089	+	Missense_Mutation	DNP	CA	CA	AG			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:67709088_67709089CA>AG	uc002eub.2	-	3	1422_1423	c.1127_1128TG>CT	c.(1126-1128)CTG>CCT	p.L376P	GFOD2_uc002eua.1_RNA|GFOD2_uc002euc.2_Missense_Mutation_p.L271P	NM_030819	NP_110446	Q3B7J2	GFOD2_HUMAN	glucose-fructose oxidoreductase domain	376						proteinaceous extracellular matrix	binding|oxidoreductase activity			ovary(2)|skin(1)	3		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0151)|Epithelial(162;0.0505)|all cancers(182;0.242)		GTGCCTCACACAGGTTCTGGTT	0.624			NA											43	28					0	0	0.004672	0	0
CIRH1A	84916	broad.mit.edu	37	16	69184491	69184491	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:69184491C>A	uc002ews.3	+	7	886	c.790C>A	c.(790-792)CAG>AAG	p.Q264K	CIRH1A_uc002ewr.2_Missense_Mutation_p.Q264K|CIRH1A_uc002ewt.3_Missense_Mutation_p.Q181K|CIRH1A_uc010cfi.2_Missense_Mutation_p.Q181K|CIRH1A_uc010cfj.1_Missense_Mutation_p.Q83K	NM_032830	NP_116219	Q969X6	CIR1A_HUMAN	cirhin	264	WD 6.					nucleolus	protein binding				0				OV - Ovarian serous cystadenocarcinoma(108;0.125)		CTTCCATTTTCAGCTGGTCCC	0.527	Melanoma(69;1156 1278 4951 8715 52012)		NA									OREG0023906	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	36	24					1.66425e-11	2.08597e-11	0.004878	1	0
GLG1	2734	broad.mit.edu	37	16	74487121	74487121	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:74487121C>A	uc002fcy.3	-	26	3534	c.3484G>T	c.(3484-3486)GGC>TGC	p.G1162C	GLG1_uc002fcx.2_Missense_Mutation_p.G1162C|GLG1_uc002fcw.3_Missense_Mutation_p.G1151C|GLG1_uc002fcz.3_Missense_Mutation_p.G579C	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	1162	Helical; (Potential).					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						CACATCAGGCCAATCAGGAAC	0.488			NA											35	24					1.30998e-17	1.84928e-17	0.005524	1	0
RFWD3	55159	broad.mit.edu	37	16	74662385	74662385	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:74662385T>A	uc002fda.2	-	11	2032	c.1934A>T	c.(1933-1935)AAC>ATC	p.N645I	RFWD3_uc010vmx.1_Missense_Mutation_p.N165I|RFWD3_uc010cgq.2_Missense_Mutation_p.N645I	NM_018124	NP_060594	Q6PCD5	RFWD3_HUMAN	ring finger and WD repeat domain 3	645					DNA repair|mitotic cell cycle G1/S transition DNA damage checkpoint|response to ionizing radiation	nucleus	MDM2 binding|p53 binding|ubiquitin-protein ligase activity|zinc ion binding			lung(2)|breast(1)	3						CCGGGAGCTGTTCTCTGTCTG	0.522			NA											40	16					0	0	0.004878	0	0
MON1B	22879	broad.mit.edu	37	16	77227493	77227493	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:77227493G>A	uc002fez.2	+	3	624	c.294G>A	c.(292-294)GGG>GGA	p.G98G	MON1B_uc010vnf.1_Intron|MON1B_uc010vng.1_Intron|MON1B_uc002ffa.2_5'Flank	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	98							protein binding				0						GCCAGGGCGGGGACCCCAGTG	0.617			NA											19	15					0	0	0.007413	0	0
ADAD2	161931	broad.mit.edu	37	16	84229633	84229633	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:84229633G>A	uc002fhr.2	+	7	1379	c.1265G>A	c.(1264-1266)AGC>AAC	p.S422N	ADAD2_uc002fhq.2_Missense_Mutation_p.S504N|uc002fhs.1_Intron	NM_001145400	NP_001138872	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2 isoform	422	A to I editase.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding				0						CCACTCTACAGCACCAGCCTC	0.677			NA											16	7					0	0	0.004007	0	0
FOXF1	2294	broad.mit.edu	37	16	86544356	86544356	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:86544356A>T	uc002fjl.2	+	1	224	c.181A>T	c.(181-183)ATC>TTC	p.I61F	uc002fjk.1_5'Flank	NM_001451	NP_001442	Q12946	FOXF1_HUMAN	forkhead box F1	61	Fork-head.				branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding				0						CGTCATGGCCATCCAGAGTTC	0.647			NA											13	5					0	0	0.001855	0	0
CBFA2T3	863	broad.mit.edu	37	16	88968062	88968062	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:88968062G>T	uc002fmm.1	-	2	340	c.154C>A	c.(154-156)CCA>ACA	p.P52T	CBFA2T3_uc002fml.1_5'UTR|CBFA2T3_uc010cif.1_5'UTR|CBFA2T3_uc002fmn.1_Missense_Mutation_p.P52T	NM_005187	NP_005178	O75081	MTG16_HUMAN	myeloid translocation gene on chromosome 16	52	Mediates localization to the nucleus (By similarity).|Pro-rich.|Mediates interaction with PDE7A (in isoform 2).|Required for nucleolar targeting (in isoform 1).	Breakpoint for translocation to form type-1 RUNX1-CBFA2T3 fusion protein.			cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(3)|ovary(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0275)		CTGTCCACTGGGGCTGCGACC	0.667			NA	T	RUNX1	AML								11	6					0.000673444	0.000705548	0.008291	1	0
ZNF276	92822	broad.mit.edu	37	16	89789078	89789078	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:89789078G>T	uc002fos.3	+	2	442	c.345G>T	c.(343-345)CGG>CGT	p.R115R	C16orf7_uc002fol.1_5'Flank|C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Silent_p.R40R|ZNF276_uc002foq.3_Silent_p.R40R|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	115	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TGCTCGTACGGGACTTCCAGC	0.647			NA											35	10					2.52637e-11	3.16042e-11	0.005524	1	0
OR1A2	26189	broad.mit.edu	37	17	3101025	3101025	+	Missense_Mutation	SNP	C	C	G	rs141816732		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:3101025C>G	uc002fvd.1	+	1	213	c.213C>G	c.(211-213)ATC>ATG	p.I71M		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	71	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I71I(1)		skin(2)	2						TGGTTGACATCATCTTCTCAT	0.483			NA											34	204					0	0	0.004878	0	0
OR3A2	4995	broad.mit.edu	37	17	3181358	3181358	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:3181358T>C	uc002fvg.2	-	1	911	c.872A>G	c.(871-873)AAC>AGC	p.N291S		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	291	Helical; Name=7; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CAGCATAGGGTTGATAACAGT	0.453	GBM(166;478 2018 3875 5042 31983)|Esophageal Squamous(77;407 1232 1405 14297 15272)		NA											12	48					0	0	0.001368	0	0
P2RX5	5026	broad.mit.edu	37	17	3593389	3593389	+	Missense_Mutation	SNP	G	G	A	rs143709684	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:3593389G>A	uc002fwi.2	-	6	873	c.589C>T	c.(589-591)CGT>TGT	p.R197C	P2RX5_uc002fwd.2_RNA|P2RX5_uc002fwh.1_Missense_Mutation_p.R197C|P2RX5_uc010vrx.1_Missense_Mutation_p.R137C|P2RX5_uc002fwj.2_Missense_Mutation_p.R173C|P2RX5_uc002fwk.2_Missense_Mutation_p.R197C|P2RX5_uc002fwl.2_Missense_Mutation_p.R173C	NM_002561	NP_002552	Q93086	P2RX5_HUMAN	purinergic receptor P2X5 isoform A	197	Extracellular (Potential).				nervous system development|positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity				0						TTGGGGAAACGGATGTGGTTC	0.587			NA											142	138					0	0	0.00361	0	0
GSG2	83903	broad.mit.edu	37	17	3628116	3628116	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:3628116G>T	uc002fwp.2	+	1	920	c.887G>T	c.(886-888)GGC>GTC	p.G296V	ITGAE_uc002fwo.3_Intron|ITGAE_uc002fwn.3_5'Flank	NM_031965	NP_114171	Q8TF76	HASP_HUMAN	haspin	296					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity				0						AGGGCCACAGGCCAGGACTCT	0.567			NA											44	25					1.22674e-20	1.83206e-20	0.00874	1	0
NLRP1	22861	broad.mit.edu	37	17	5418227	5418227	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:5418227G>T	uc002gci.2	-	17	4824	c.4269C>A	c.(4267-4269)CCC>CCA	p.P1423P	NLRP1_uc002gcg.1_Intron|NLRP1_uc002gck.2_Silent_p.P1379P|NLRP1_uc002gcj.2_Silent_p.P1393P|NLRP1_uc002gcl.2_Silent_p.P1349P|NLRP1_uc002gch.3_Silent_p.P1379P	NM_033004	NP_127497	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1 isoform 1	1423	CARD.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			lung(4)|breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	9		Colorectal(1115;3.48e-05)				GCATCTGGCTGGGCCTCGTGT	0.572			NA											20	33					8.34094e-07	9.35694e-07	0.008871	1	0
WSCD1	23302	broad.mit.edu	37	17	5998421	5998421	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:5998421G>T	uc010cli.2	+	5	1107	c.728_splice	c.e5-1	p.R243_splice	WSCD1_uc002gcn.2_Splice_Site_p.R243_splice|WSCD1_uc002gco.2_Splice_Site_p.R243_splice|WSCD1_uc010clj.2_Splice_Site	NM_015253	NP_056068	Q658N2	WSCD1_HUMAN	WSC domain containing 1							integral to membrane	sulfotransferase activity				0						TTTTCCCCCAGGGCGGACCGC	0.557			NA											46	129					1.67753e-36	2.90451e-36	0.00361	1	0
FBXO39	162517	broad.mit.edu	37	17	6684114	6684114	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:6684114G>A	uc010vtg.1	+	2	1047	c.927G>A	c.(925-927)AGG>AGA	p.R309R		NM_153230	NP_694962	Q8N4B4	FBX39_HUMAN	F-box protein 39	309										ovary(1)|skin(1)	2						TCCCGATCAGGAGCATCAGTC	0.527			NA											40	30					0	0	0.00623	0	0
SPEM1	374768	broad.mit.edu	37	17	7323846	7323846	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:7323846T>A	uc002ggv.2	+	1	168	c.143T>A	c.(142-144)CTG>CAG	p.L48Q	FGF11_uc010vtw.1_Intron	NM_199339	NP_955371	Q8N4L4	SPEM1_HUMAN	spermatid maturation 1	48	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm|integral to membrane					0		Prostate(122;0.173)				ATAGTGACCCTGGTCAGGGTG	0.597			NA											21	55					0	0	0.008871	0	0
POLR2A	5430	broad.mit.edu	37	17	7411605	7411605	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:7411605G>T	uc002ghf.3	+	20	3510	c.3276G>T	c.(3274-3276)GCG>GCT	p.A1092A		NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	1092					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				CTCTGGCTGCGCAGTCCCTTG	0.542			NA											13	10					0.00010058	0.000107352	0.001368	1	0
TP53	7157	broad.mit.edu	37	17	7574017	7574017	+	Missense_Mutation	SNP	C	C	A	rs121912664		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:7574017C>A	uc002gim.2	-	10	1204	c.1010G>T	c.(1009-1011)CGC>CTC	p.R337L	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Intron|TP53_uc010cne.1_Intron|TP53_uc010cnf.1_3'UTR|TP53_uc010cng.1_3'UTR|TP53_uc002gii.1_Missense_Mutation_p.R205L|TP53_uc010cnh.1_3'UTR|TP53_uc010cni.1_3'UTR|TP53_uc002gij.2_Missense_Mutation_p.R337L	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	337	Oligomerization.|Interaction with HIPK1 (By similarity).|Interaction with CARM1.|Interaction with HIPK2.		R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(12)|p.0?(7)|p.R337L(5)|p.R337H(2)|p.?(1)|p.I332fs*5(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CATCTCGAAGCGCTCACGCCC	0.453	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			32	8					6.97489e-18	9.91141e-18	0.004878	1	0
DNAH2	146754	broad.mit.edu	37	17	7727220	7727220	+	Missense_Mutation	SNP	G	G	A	rs61739646		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:7727220G>A	uc002giu.1	+	74	11412	c.11398G>A	c.(11398-11400)GTG>ATG	p.V3800M	DNAH2_uc010cnm.1_Missense_Mutation_p.V738M	NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	3800					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CCAGGACCGCGTGGCCTTCTG	0.582			NA											98	10					0	0	0.00361	0	0
GUCY2D	3000	broad.mit.edu	37	17	7910409	7910409	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:7910409C>T	uc002gjt.2	+	5	1484	c.1410C>T	c.(1408-1410)TTC>TTT	p.F470F		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	470	Helical; (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TTCTTGGCTTCCTCCTGGTGG	0.572			NA											28	62					0	0	0.008361	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8222142	8222142	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:8222142G>T	uc002glc.2	+	12	2068	c.1947G>T	c.(1945-1947)GGG>GGT	p.G649G	ARHGEF15_uc002gld.2_Silent_p.G649G|ARHGEF15_uc010vuw.1_Silent_p.G538G	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	649					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GCCGGAGGGGGGGCGTGCTCT	0.647			NA											82	250					2.1672e-28	3.56105e-28	0.00361	1	0
MYH10	4628	broad.mit.edu	37	17	8408032	8408032	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:8408032C>T	uc002gll.2	-	26	3582	c.3486G>A	c.(3484-3486)ACG>ACA	p.T1162T	MYH10_uc002glm.2_Silent_p.T1193T|MYH10_uc010cnx.2_Silent_p.T1171T	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1162	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						GCTGGGCTGCCGTGGTGTCCA	0.607			NA											9	145					0	0	0.008291	0	0
MYH13	8735	broad.mit.edu	37	17	10265475	10265475	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10265475G>T	uc002gmk.1	-	5	555	c.465C>A	c.(463-465)ATC>ATA	p.I155I		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	155	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						AGATGGAGAAGATGTGGGGCG	0.488			NA											101	78					2.91419e-48	5.28709e-48	0.00361	1	0
MYH8	4626	broad.mit.edu	37	17	10303742	10303742	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10303742G>T	uc002gmm.2	-	27	3795	c.3700C>A	c.(3700-3702)CTC>ATC	p.L1234I	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	1234	Potential.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						TTACTGCTGAGGTCATCAGTC	0.463			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				51	140					5.39261e-20	7.93707e-20	0.00361	1	0
MYH8	4626	broad.mit.edu	37	17	10314148	10314148	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10314148C>A	uc002gmm.2	-	15	1628	c.1533G>T	c.(1531-1533)TGG>TGT	p.W511C	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	511	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CAATGAACGTCCACTCGATGC	0.488			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				40	125					3.78316e-11	4.7204e-11	0.00623	1	0
MYH8	4626	broad.mit.edu	37	17	10318833	10318833	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10318833C>A	uc002gmm.2	-	7	699	c.604G>T	c.(604-606)GCA>TCA	p.A202S	uc002gml.1_Intron	NM_002472	NP_002463	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle,	202	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			skin(6)|ovary(3)|breast(2)	11						CCAGTAACTGCAATTGTTGCA	0.458			NA							Trismus-Pseudocamptodactyly_Syndrome_with_Cardiac_Myxoma_and_Freckling				53	59					7.41606e-26	1.18731e-25	0.00361	1	0
MYH1	4619	broad.mit.edu	37	17	10398511	10398511	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10398511C>T	uc002gmo.2	-	36	5387	c.5293G>A	c.(5293-5295)GAT>AAT	p.D1765N	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1765	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCACTCACATCAGTGATGGCC	0.458			NA											48	155					0	0	0.00361	0	0
MYH1	4619	broad.mit.edu	37	17	10402067	10402067	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10402067C>A	uc002gmo.2	-	30	4151	c.4057G>T	c.(4057-4059)GAG>TAG	p.E1353*	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1353	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCCTGCTCCTCCTCATACTGT	0.552			NA											86	53					7.7321e-48	1.39887e-47	0.00361	1	0
MYH1	4619	broad.mit.edu	37	17	10406204	10406204	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10406204C>A	uc002gmo.2	-	24	3056	c.2962G>T	c.(2962-2964)GGT>TGT	p.G988C	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	988	Potential.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TCATCCAGACCCGCCATCTCT	0.507			NA											42	183					2.35958e-20	3.49421e-20	0.009718	1	0
MYH1	4619	broad.mit.edu	37	17	10415180	10415180	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10415180G>T	uc002gmo.2	-	14	1486	c.1392C>A	c.(1390-1392)GAC>GAA	p.D464E	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	464	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						AGCCAGCAATGTCCAAGACCC	0.463			NA											109	89					4.58075e-42	8.15761e-42	0.00361	1	0
MYH2	4620	broad.mit.edu	37	17	10428226	10428226	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10428226G>T	uc010coi.2	-	34	4947	c.4819C>A	c.(4819-4821)CTG>ATG	p.L1607M	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.L1607M|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1607	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCAGCATCCAGCGTGCTCTGC	0.458			NA											82	60					1.52223e-32	2.58472e-32	0.00361	1	0
MYH2	4620	broad.mit.edu	37	17	10432523	10432523	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:10432523G>A	uc010coi.2	-	26	3438	c.3310C>T	c.(3310-3312)CAG>TAG	p.Q1104*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.Q1104*|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1104	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						CCAAGTGCCTGTTCATCTTCA	0.373			NA											12	46					0	0	0.001368	0	0
DNAH9	1770	broad.mit.edu	37	17	11572494	11572494	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:11572494G>T	uc002gne.2	+	16	2913	c.2845G>T	c.(2845-2847)GTT>TTT	p.V949F	DNAH9_uc010coo.2_Missense_Mutation_p.V243F	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	949	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTGTGACATTGTTGAGGGTCT	0.498			NA											83	25					9.5978e-63	1.78311e-62	0.00361	1	0
NCOR1	9611	broad.mit.edu	37	17	15971414	15971414	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:15971414G>C	uc002gpo.2	-	32	4775	c.4535C>G	c.(4534-4536)TCT>TGT	p.S1512C	NCOR1_uc002gpn.2_Missense_Mutation_p.S1528C|NCOR1_uc002gpm.2_Missense_Mutation_p.S33C|NCOR1_uc010vwb.1_Missense_Mutation_p.S96C|NCOR1_uc010coy.2_Missense_Mutation_p.S420C|NCOR1_uc010vwc.1_Missense_Mutation_p.S323C	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1512	Interaction with ETO.|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		ATGATTGGTAGACTTGTTAGA	0.438			NA											10	10					0	0	0.006214	0	0
ZNF287	57336	broad.mit.edu	37	17	16456737	16456737	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:16456737C>A	uc002gqi.2	-	6	1172	c.719G>T	c.(718-720)TGG>TTG	p.W240L		NM_020653	NP_065704	Q9HBT7	ZN287_HUMAN	zinc finger protein 287	233					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TTTAGTTTCCCATTCTGaaat	0.318			NA											30	7					3.65163e-15	4.918e-15	0.00632	1	0
FLJ40504	284085	broad.mit.edu	37	17	26603976	26603976	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:26603976T>C	uc002has.3	-	3	595	c.499A>G	c.(499-501)ACC>GCC	p.T167A		NM_173624	NP_775895			SubName: Full=Putative uncharacterized protein FLJ40504; SubName: Full=cDNA FLJ40504 fis, clone TESTI2045509, highly similar to KERATIN, TYPE I CYTOSKELETAL 18;												0	all_lung(13;0.000238)|Lung NSC(42;0.000789)			UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		TTCTCGATGGTCTTGAAGTCA	0.522			NA											57	35					0	0	0.00361	0	0
PIGS	94005	broad.mit.edu	37	17	26883203	26883204	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:26883203_26883204CC>AG	uc002hbo.2	-	10	1534_1535	c.1161_1162GG>CT	c.(1159-1164)GAGGTG>GACTTG	p.387_388EV>DL	PIGS_uc002hbn.2_Missense_Mutation_p.379_380EV>DL|PIGS_uc010wap.1_Missense_Mutation_p.326_327EV>DL	NM_033198	NP_149975	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	387_388	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(2)|urinary_tract(1)|kidney(1)	4	Lung NSC(42;0.00431)					GCCAGGAACACCTCCATCACTC	0.5			NA											48	47					0	0	0.004672	0	0
TAOK1	57551	broad.mit.edu	37	17	27849415	27849415	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:27849415G>C	uc002hdz.1	+	17	2220	c.2026G>C	c.(2026-2028)GAG>CAG	p.E676Q	TAOK1_uc010wbe.1_Intron|TAOK1_uc010wbf.1_Missense_Mutation_p.E676Q	NM_020791	NP_065842	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	676					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)|skin(1)	4			Colorectal(6;0.198)			GATGCGCTGTGAGTTGATCAG	0.453			NA											21	54					0	0	0.010504	0	0
SLC6A4	6532	broad.mit.edu	37	17	28530283	28530283	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:28530283G>A	uc002hey.3	-	14	2269	c.1725C>T	c.(1723-1725)ATC>ATT	p.I575I	SLC6A4_uc010csg.2_RNA	NM_001045	NP_001036	P31645	SC6A4_HUMAN	solute carrier family 6 member 4	575					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			skin(3)|ovary(1)	4					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	AACCCAAGATGATACTCCAGT	0.388			NA											69	44					0	0	0.00361	0	0
PSMD11	5717	broad.mit.edu	37	17	30774031	30774031	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:30774031G>A	uc010cta.1	+	2	200	c.160G>A	c.(160-162)GGA>AGA	p.G54R	PSMD11_uc010wbz.1_Missense_Mutation_p.G54R|PSMD11_uc002hhm.2_Missense_Mutation_p.G54R	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	54					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			CCTGGAACTGGGATCTCTCCT	0.453	Ovarian(130;1038 1716 9294 11987 19279)		NA											23	53					0	0	0.004656	0	0
CCL2	6347	broad.mit.edu	37	17	32583819	32583819	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:32583819C>A	uc002hhy.2	+	3	346	c.273C>A	c.(271-273)GAC>GAA	p.D91E		NM_002982	NP_002973	P13500	CCL2_HUMAN	small inducible cytokine A2 precursor	91				D->L: 90% reduction in activity.|Missing: 83% reduction in activity.	angiogenesis|anti-apoptosis|apoptotic cell clearance|astrocyte cell migration|cell adhesion|cellular response to interferon-gamma|cellular response to interleukin-1|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor|G-protein signaling, coupled to cyclic nucleotide second messenger|helper T cell extravasation|humoral immune response|inflammatory response|JAK-STAT cascade|macrophage chemotaxis|monocyte chemotaxis|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of T cell activation|viral genome replication	extracellular space	CCR2 chemokine receptor binding|chemokine activity|protein kinase activity|signal transducer activity			pancreas(1)	1	Breast(3;0.00224)	Ovarian(249;0.0694)|Breast(31;0.151)|Lung NSC(157;0.153)		UCEC - Uterine corpus endometrioid carcinoma (308;0.000241)|BRCA - Breast invasive adenocarcinoma(366;0.0103)	Atorvastatin(DB01076)|Danazol(DB01406)|Mimosine(DB01055)|Simvastatin(DB00641)	ACCACCTGGACAAGCAAACCC	0.507			NA											14	46					2.31682e-05	2.52152e-05	0.003163	1	0
TMEM132E	124842	broad.mit.edu	37	17	32959844	32959844	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:32959844C>A	uc002hif.2	+	7	1662	c.1334C>A	c.(1333-1335)CCC>CAC	p.P445H		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	445	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GTCTGGGTCCCCAAGCTGCCC	0.597			NA											89	75					1.82171e-49	3.31751e-49	0.00361	1	0
RFFL	117584	broad.mit.edu	37	17	33348594	33348594	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:33348594C>G	uc002hin.1	-	3	560	c.387G>C	c.(385-387)CTG>CTC	p.L129L	RFFL_uc002hiq.2_Intron|RFFL_uc002him.1_Silent_p.L129L|RFFL_uc010cti.1_Silent_p.L135L|RFFL_uc002hip.1_Silent_p.L129L|RFFL_uc002hio.1_Silent_p.L129L	NM_001017368	NP_001017368	Q8WZ73	RFFL_HUMAN	rififylin	129					apoptosis	membrane	ligase activity|zinc ion binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CCAAGAGCACCAGCTCTTCTT	0.552			NA											17	30					0	0	0.006122	0	0
AMAC1	146861	broad.mit.edu	37	17	33520510	33520510	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:33520510C>A	uc002hjd.2	-	1	903	c.817G>T	c.(817-819)GCG>TCG	p.A273S		NM_152462	NP_689675	Q8N808	AMAC1_HUMAN	acyl-malonyl condensing enzyme 1	273	DUF6 2.					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(366;0.0917)		TTGGTGACCGCATAGCCCACA	0.592			NA											126	85					5.13333e-58	9.48219e-58	0.00361	1	0
SLFN13	146857	broad.mit.edu	37	17	33771790	33771790	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:33771790C>A	uc002hjk.1	-	1	1240	c.910G>T	c.(910-912)GGG>TGG	p.G304W	SLFN13_uc010wch.1_Missense_Mutation_p.G304W|SLFN13_uc002hjl.2_Missense_Mutation_p.G304W|SLFN13_uc010ctt.2_Intron|SLFN13_uc002hjm.2_Intron	NM_144682	NP_653283	Q68D06	SLN13_HUMAN	schlafen family member 13	304						intracellular	ATP binding			ovary(1)|breast(1)	2				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AACTCTTTCCCACAAAACACT	0.418			NA											53	54					1.86277e-20	2.77336e-20	0.00361	1	0
PEX12	5193	broad.mit.edu	37	17	33903138	33903138	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:33903138G>C	uc002hjp.2	-	3	1359	c.743C>G	c.(742-744)TCT>TGT	p.S248C		NM_000286	NP_000277	O00623	PEX12_HUMAN	peroxisomal biogenesis factor 12	248	Helical; (Potential).				protein import into peroxisome matrix	integral to peroxisomal membrane	protein C-terminus binding|zinc ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AAGGCCAGTAGACAGGGATAA	0.453			NA											36	31					0	0	0.004878	0	0
GAS2L2	246176	broad.mit.edu	37	17	34077228	34077228	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:34077228C>G	uc002hjv.1	-	2	523	c.495G>C	c.(493-495)GCG>GCC	p.A165A		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	165					cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CGAGTGTGGGCGCCGCAACAC	0.706			NA											73	200					0	0	0.00361	0	0
CCL23	6368	broad.mit.edu	37	17	34344875	34344875	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:34344875C>A	uc002hkt.1	-	1	131	c.60G>T	c.(58-60)CAG>CAT	p.Q20H	CCL23_uc002hks.1_Missense_Mutation_p.Q20H	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	20				MLVTALGSQARVTKDAETEFMMSKLPLENPVLL -> HAFL LPLVPGPGHKRCRDRVHECQSFHWKIQYFW (in Ref. 1).	cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	TGACCCGGGCCTGGGATCCAA	0.587			NA											16	22					1.02788e-11	1.29422e-11	0.00499	1	0
STAC2	342667	broad.mit.edu	37	17	37371051	37371051	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:37371051C>A	uc002hrs.2	-	7	1055	c.836G>T	c.(835-837)GGA>GTA	p.G279V	STAC2_uc010cvt.2_Missense_Mutation_p.G137V	NM_198993	NP_945344	Q6ZMT1	STAC2_HUMAN	SH3 and cysteine rich domain 2	279					intracellular signal transduction		metal ion binding			pancreas(1)	1						CACCTGCTGTCCAGGACTCTT	0.582			NA											31	8					1.80694e-10	2.21459e-10	0.009535	1	0
MED24	9862	broad.mit.edu	37	17	38209742	38209742	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:38209742C>A	uc002htt.2	-	2	423	c.110G>T	c.(109-111)TGG>TTG	p.W37L	MED24_uc010wet.1_RNA|MED24_uc002hts.2_Missense_Mutation_p.W62L|MED24_uc002htu.2_Missense_Mutation_p.W37L|MED24_uc010cwn.2_Missense_Mutation_p.W37L|MED24_uc010weu.1_5'UTR|MED24_uc010wev.1_Intron|MED24_uc010wew.1_Intron|MED24_uc010wex.1_5'Flank|MED24_uc010wfa.1_5'Flank|MED24_uc010wfb.1_Missense_Mutation_p.W62L|MED24_uc010wfc.1_5'Flank	NM_014815	NP_055630	O75448	MED24_HUMAN	mediator complex subunit 24 isoform 1	37					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)	1	Colorectal(19;0.000442)					GAGAATATCCCAGGTGGCTCC	0.463			NA											209	38					7.15034e-89	1.34915e-88	0.00361	1	0
KRT33A	3883	broad.mit.edu	37	17	39506848	39506848	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:39506848C>G	uc002hwk.1	-	1	209	c.172G>C	c.(172-174)GAG>CAG	p.E58Q		NM_004138	NP_004129	O76009	KT33A_HUMAN	keratin 33A	58	Coil 1A.|Rod.					intermediate filament	protein binding|structural molecule activity				0		Breast(137;0.000496)				TGCATGGTCTCCTTCTCACTG	0.632			NA											110	24					0	0	0.00361	0	0
KRT34	3885	broad.mit.edu	37	17	39538006	39538006	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:39538006G>C	uc002hwm.2	-	2	528	c.516C>G	c.(514-516)AAC>AAG	p.N172K		NM_021013	NP_066293	O76011	KRT34_HUMAN	keratin 34	172	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)	1		Breast(137;0.000496)				CATTGTCAATGTTCACCACCA	0.448			NA											62	12					0	0	0.00361	0	0
HAP1	9001	broad.mit.edu	37	17	39883375	39883375	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:39883375C>A	uc002hxm.1	-	10	1465	c.1453G>T	c.(1453-1455)GAG>TAG	p.E485*	JUP_uc010wfs.1_Intron|HAP1_uc002hxn.1_Nonsense_Mutation_p.E433*|HAP1_uc002hxo.1_Nonsense_Mutation_p.E416*|HAP1_uc002hxp.1_Nonsense_Mutation_p.E408*	NM_177977	NP_817084	P54257	HAP1_HUMAN	huntingtin-associated protein 1 isoform 2	485	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			ovary(2)	2		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			GCCAGCGTCTCCTGGAAACCA	0.572			NA											15	4					6.81908e-15	9.12671e-15	0.00245	1	0
SLC4A1	6521	broad.mit.edu	37	17	42332001	42332001	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:42332001C>G	uc002igf.3	-	16	2069	c.1920G>C	c.(1918-1920)GTG>GTC	p.V640V		NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	640	Extracellular (Potential).|Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		AGGAGTTGGACACCTTGAAGC	0.617			NA											22	2					0	0	0.010504	0	0
SLC4A1	6521	broad.mit.edu	37	17	42333059	42333059	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:42333059G>T	uc002igf.3	-	14	1931	c.1782C>A	c.(1780-1782)AGC>AGA	p.S594R		NM_000342	NP_000333	P02730	B3AT_HUMAN	solute carrier family 4, anion exchanger, member	594	Involved in anion transport.|Cytoplasmic (Potential).|Membrane (anion exchange).				bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GGAAATAGGAGCTGTTCTTGA	0.592			NA											50	9					2.43468e-25	3.87545e-25	0.00361	1	0
MAPT	4137	broad.mit.edu	37	17	44060875	44060875	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:44060875C>G	uc002ijr.3	+	6	1025	c.705C>G	c.(703-705)TCC>TCG	p.S235S	MAPT_uc010dau.2_Silent_p.S235S|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	235					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				CCCCTCCCTCCAAGGCCTCCC	0.687			NA											19	15					0	0	0.001882	0	0
HOXB4	3214	broad.mit.edu	37	17	46654196	46654196	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:46654196A>T	uc002inp.2	-	2	706	c.644T>A	c.(643-645)ATG>AAG	p.M215K	HOXB3_uc010wlm.1_Intron|HOXB3_uc010dbf.2_Intron|HOXB3_uc010dbg.2_Intron|HOXB3_uc002ino.2_5'Flank|HOXB3_uc010wlk.1_5'Flank|HOXB3_uc010wll.1_Intron	NM_024015	NP_076920	P17483	HXB4_HUMAN	homeobox B4	215	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TTTCCACTTCATGCGCCGGTT	0.652			NA											111	25					0	0	0.00361	0	0
TTLL6	284076	broad.mit.edu	37	17	46868791	46868791	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:46868791G>C	uc010wlo.1	-	10	1208	c.1173C>G	c.(1171-1173)ATC>ATG	p.I391M	TTLL6_uc002iob.2_Missense_Mutation_p.I84M|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.I144M|TTLL6_uc002iod.2_Missense_Mutation_p.I238M	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	343	TTL.					cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						CAAAGCCCAGGATCTCAAAGC	0.542			NA									OREG0024526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	4					0	0	0.005443	0	0
ABI3	51225	broad.mit.edu	37	17	47295217	47295217	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:47295217G>T	uc002iop.1	+	3	900	c.402G>T	c.(400-402)ACG>ACT	p.T134T	ABI3_uc002ioq.1_Silent_p.T128T	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	134					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CCCCTCTCACGCCCTACTGCA	0.632			NA								HNSCC(55;0.14)			67	13					4.15811e-52	7.61532e-52	0.00361	1	0
ABI3	51225	broad.mit.edu	37	17	47297633	47297633	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:47297633C>A	uc002iop.1	+	6	1245	c.747C>A	c.(745-747)GCC>GCA	p.A249A	ABI3_uc002ioq.1_Silent_p.A243A	NM_016428	NP_057512	Q9P2A4	ABI3_HUMAN	NESH protein isoform 1	249	Pro-rich.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding				0			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			CACCAGCAGCCGTCGAGGTGT	0.692			NA								HNSCC(55;0.14)			17	3					9.16793e-09	1.08578e-08	0.00499	1	0
SGCA	6442	broad.mit.edu	37	17	48245326	48245326	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:48245326G>A	uc002iqi.2	+	4	367	c.331G>A	c.(331-333)GAC>AAC	p.D111N	SGCA_uc010wmh.1_Missense_Mutation_p.D9N|SGCA_uc002iqj.2_Missense_Mutation_p.D111N|SGCA_uc010wmi.1_RNA	NM_000023	NP_000014	Q16586	SGCA_HUMAN	sarcoglycan, alpha isoform 1 precursor	111	Extracellular (Potential).				muscle contraction|muscle organ development	cytoplasm|cytoskeleton|integral to membrane|sarcoglycan complex|sarcolemma	calcium ion binding			ovary(2)	2						CTACAATCGGGACAGCTTTGA	0.587			NA											69	23					0	0	0.00361	0	0
CACNA1G	8913	broad.mit.edu	37	17	48696314	48696314	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:48696314T>C	uc002irk.1	+	33	6098	c.5726T>C	c.(5725-5727)CTG>CCG	p.L1909P	CACNA1G_uc002irj.1_Missense_Mutation_p.L1875P|CACNA1G_uc002irl.1_Missense_Mutation_p.L1886P|CACNA1G_uc002irm.1_Missense_Mutation_p.L1875P|CACNA1G_uc002irn.1_Missense_Mutation_p.L1868P|CACNA1G_uc002iro.1_Missense_Mutation_p.L1875P|CACNA1G_uc002irp.1_Missense_Mutation_p.L1909P|CACNA1G_uc002irq.1_Missense_Mutation_p.L1886P|CACNA1G_uc002irr.1_Missense_Mutation_p.L1909P|CACNA1G_uc002irs.1_Missense_Mutation_p.L1898P|CACNA1G_uc002irt.1_Missense_Mutation_p.L1891P|CACNA1G_uc002irv.1_Missense_Mutation_p.L1898P|CACNA1G_uc002irw.1_Missense_Mutation_p.L1886P|CACNA1G_uc002iru.1_Missense_Mutation_p.L1875P|CACNA1G_uc002irx.1_Missense_Mutation_p.L1822P|CACNA1G_uc002iry.1_Missense_Mutation_p.L1811P|CACNA1G_uc002irz.1_Missense_Mutation_p.L1815P|CACNA1G_uc002isa.1_Missense_Mutation_p.L1788P|CACNA1G_uc002isb.1_Missense_Mutation_p.L1829P|CACNA1G_uc002isc.1_Missense_Mutation_p.L1811P|CACNA1G_uc002isd.1_Missense_Mutation_p.L1797P|CACNA1G_uc002ise.1_Missense_Mutation_p.L1777P|CACNA1G_uc002isf.1_Missense_Mutation_p.L1804P|CACNA1G_uc002isg.1_Missense_Mutation_p.L1770P|CACNA1G_uc002ish.1_Missense_Mutation_p.L1777P|CACNA1G_uc002isi.1_Missense_Mutation_p.L1765P	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1909	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGGGGCTCTGCACCCAGCG	0.711			NA											26	7					0	0	0.007291	0	0
CA10	56934	broad.mit.edu	37	17	49825100	49825100	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:49825100C>G	uc002itw.3	-	4	1344	c.358G>C	c.(358-360)GGG>CGG	p.G120R	CA10_uc002itu.3_Missense_Mutation_p.G49R|CA10_uc002itv.3_Missense_Mutation_p.G126R|CA10_uc002itx.3_Missense_Mutation_p.G120R|CA10_uc002ity.3_Missense_Mutation_p.G120R|CA10_uc002itz.2_Missense_Mutation_p.G120R	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	120					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTCATGGGCCCTCCAGATATG	0.557			NA											74	13					0	0	0.00361	0	0
RNF43	54894	broad.mit.edu	37	17	56435163	56435163	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:56435163C>A	uc002iwf.2	-	8	3930	c.1974G>T	c.(1972-1974)GGG>GGT	p.G658G	RNF43_uc010wnv.1_Silent_p.G617G|RNF43_uc002iwh.3_Silent_p.G658G|RNF43_uc002iwg.3_Silent_p.G658G|RNF43_uc010dcw.2_Silent_p.G531G	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	658	Pro-rich.|Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CGGAGGGACCCCCCCGCCTTT	0.602			NA											90	28					1.80868e-48	3.28449e-48	0.00361	1	0
RNF43	54894	broad.mit.edu	37	17	56438273	56438273	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:56438273G>A	uc002iwf.2	-	6	2676	c.720C>T	c.(718-720)ATC>ATT	p.I240I	RNF43_uc010wnv.1_Silent_p.I199I|RNF43_uc002iwh.3_Silent_p.I240I|RNF43_uc002iwg.3_Silent_p.I240I|RNF43_uc010dcw.2_Silent_p.I113I	NM_017763	NP_060233	Q68DV7	RNF43_HUMAN	ring finger protein 43 precursor	240	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			ovary(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCAGCTGGCTGATGGCCCAGG	0.652			NA											19	4					0	0	0.010504	0	0
MED13	9969	broad.mit.edu	37	17	60107008	60107009	+	Missense_Mutation	DNP	TC	TC	GA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:60107008_60107009TC>GA	uc002izo.2	-	8	1253_1254	c.1176_1177GA>TC	c.(1174-1179)AGGAAG>AGTCAG	p.392_393RK>SQ	MED13_uc002izp.2_Missense_Mutation_p.8_9RK>SQ	NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	392_393					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GCAGAATACTTCCTCCTAAGAT	0.337			NA											32	6					0	0	0.004672	0	0
SMARCD2	6603	broad.mit.edu	37	17	61911024	61911024	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:61911024C>T	uc010deb.1	-	10	1557	c.1240G>A	c.(1240-1242)GAC>AAC	p.D414N	SMARCD2_uc010wpt.1_Missense_Mutation_p.D366N|SMARCD2_uc010dea.1_Missense_Mutation_p.D339N|SMARCD2_uc010dec.1_Missense_Mutation_p.D393N	NM_001098426	NP_001091896	Q92925	SMRD2_HUMAN	SWI/SNF-related matrix-associated	414					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity				0						TTCAGTGGGTCGTCCACCTCC	0.562			NA											13	51					0	0	0.00245	0	0
GH2	2689	broad.mit.edu	37	17	61957865	61957865	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:61957865C>A	uc002jco.1	-	5	532	c.470G>T	c.(469-471)GGC>GTC	p.G157V	GH2_uc002jcj.2_Intron|CSH2_uc002jck.2_Intron|GH2_uc002jcl.1_Missense_Mutation_p.W241C|GH2_uc002jcm.1_Missense_Mutation_p.A156S|GH2_uc002jcn.1_Missense_Mutation_p.G142V	NM_002059	NP_002050	P01242	SOM2_HUMAN	growth hormone 2 isoform 1	157						extracellular region	hormone activity			upper_aerodigestive_tract(2)|pancreas(1)	3						CCGGGGGCTGCCATCTTCCAG	0.542			NA											69	11					9.68594e-22	1.47153e-21	0.00361	1	0
ABCA6	23460	broad.mit.edu	37	17	67079063	67079063	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:67079063C>G	uc002jhw.1	-	36	4742	c.4567G>C	c.(4567-4569)GTC>CTC	p.V1523L		NM_080284	NP_525023	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A, member 6	1523					transport	integral to membrane	ATP binding|ATPase activity			upper_aerodigestive_tract(2)|large_intestine(2)|ovary(2)|skin(1)	7	Breast(10;5.65e-12)					TCAGTGTGGACCAAAGTCACT	0.453			NA											140	47					0	0	0.00361	0	0
ABCA10	10349	broad.mit.edu	37	17	67186585	67186585	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:67186585T>A	uc010dfa.1	-	19	2924	c.2045A>T	c.(2044-2046)CAG>CTG	p.Q682L	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_Missense_Mutation_p.Q283L	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	682					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					CCTTATGCCCTGGTCAGAACA	0.313			NA											27	8					0	0	0.009535	0	0
TRIM47	91107	broad.mit.edu	37	17	73870763	73870763	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:73870763C>A	uc002jpw.2	-	6	1745	c.1718G>T	c.(1717-1719)CGG>CTG	p.R573L	TRIM47_uc002jpv.2_Missense_Mutation_p.R335L	NM_033452	NP_258411	Q96LD4	TRI47_HUMAN	tripartite motif-containing 47	573	B30.2/SPRY.					cytoplasm|nucleus	zinc ion binding			ovary(2)|prostate(1)|lung(1)|breast(1)	5			Epithelial(20;4.23e-06)|all cancers(21;5.24e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTTCAGCCTCCGCAGGAGGCT	0.677			NA											40	11					2.87052e-16	3.9485e-16	0.005524	1	0
MGAT5B	146664	broad.mit.edu	37	17	74902137	74902137	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:74902137G>T	uc002jti.2	+	7	1029	c.926G>T	c.(925-927)GGG>GTG	p.G309V	MGAT5B_uc002jth.2_Missense_Mutation_p.G298V	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	N-acetylglucosaminyltranferase VB isoform 2	298	Lumenal (Potential).					Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(2)|skin(1)	3						GAGGAGTCCGGGGACGTGTTC	0.667			NA											51	20					2.30037e-20	3.41698e-20	0.00361	1	0
AFMID	125061	broad.mit.edu	37	17	76201752	76201752	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:76201752G>A	uc002jva.3	+	9	728	c.713G>A	c.(712-714)CGT>CAT	p.R238H	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Missense_Mutation_p.R238H	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	238						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CCCACCTGCCGTGTGCTGGTG	0.647			NA											32	6					0	0	0.002445	0	0
ENPP7	339221	broad.mit.edu	37	17	77711769	77711769	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:77711769C>A	uc002jxa.2	+	5	1321	c.1301C>A	c.(1300-1302)GCT>GAT	p.A434D		NM_178543	NP_848638	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	434	Helical; (Potential).				negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			central_nervous_system(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GGAAGATCTGCTCTCCCGCCC	0.597			NA											55	17					2.17126e-26	3.49352e-26	0.00361	1	0
TSPAN10	83882	broad.mit.edu	37	17	79612613	79612613	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:79612613G>A	uc010die.2	+	2	722	c.632G>A	c.(631-633)AGG>AAG	p.R211K	TSPAN10_uc002kaw.1_Missense_Mutation_p.R211K|TSPAN10_uc010did.1_RNA	NM_031945	NP_114151	Q9H1Z9	TSN10_HUMAN	tetraspanin 10	211						integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CTCGGGCTGAGGTGCTGCGGA	0.632			NA											15	4					0	0	0.00245	0	0
ZFP161	7541	broad.mit.edu	37	18	5291177	5291177	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:5291177G>A	uc002kmq.2	-	4	1191	c.1030C>T	c.(1030-1032)CGT>TGT	p.R344C	ZFP161_uc002kmr.2_Missense_Mutation_p.R344C|ZFP161_uc010dkp.2_Missense_Mutation_p.R344C	NM_003409	NP_003400	O43829	ZF161_HUMAN	zinc finger protein 161 homolog	344	C2H2-type 3.				negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TCTGGGGCACGGATAAATGAT	0.448			NA											107	14					0	0	0.00361	0	0
PTPRM	5797	broad.mit.edu	37	18	8370953	8370953	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:8370953A>G	uc002knn.3	+	22	3584	c.3081A>G	c.(3079-3081)ATA>ATG	p.I1027M	PTPRM_uc010dkv.2_Missense_Mutation_p.I1040M|PTPRM_uc010wzl.1_Missense_Mutation_p.I814M	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1027	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				TTACCCTAATAGAAACAGAAC	0.338			NA											23	41					0	0	0.002299	0	0
KIAA0802	23255	broad.mit.edu	37	18	8784148	8784148	+	Missense_Mutation	SNP	C	C	A	rs141911404		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:8784148C>A	uc002knr.2	+	6	1180	c.1038C>A	c.(1036-1038)AGC>AGA	p.S346R	KIAA0802_uc002knq.2_Missense_Mutation_p.S346R|KIAA0802_uc010dkw.1_Missense_Mutation_p.S184R	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	697	Potential.										0						TGCAGATCAGCGAGCTCAGCG	0.692			NA											32	49					2.08457e-15	2.82124e-15	0.002096	1	0
NDUFV2	4729	broad.mit.edu	37	18	9122556	9122556	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:9122556G>C	uc002knu.2	+	5	413	c.346G>C	c.(346-348)GCA>CCA	p.A116P		NM_021074	NP_066552	P19404	NDUV2_HUMAN	NADH dehydrogenase ubiquinone flavoprotein 2	116					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)	ATATGAAGTAGCAACTTTTTA	0.348			NA											63	27					0	0	0.00361	0	0
FAM38B	63895	broad.mit.edu	37	18	10671667	10671667	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:10671667G>T	uc002kor.3	-	14	2127	c.1987C>A	c.(1987-1989)CGA>AGA	p.R663R	FAM38B_uc002koq.2_Silent_p.R498R	NM_022068	NP_071351	Q9H5I5	PIEZ2_HUMAN	family with sequence similarity 38, member B	2706						integral to membrane	ion channel activity			ovary(1)	1						TTCAAAATTCGATCCACATTT	0.378			NA											32	6					9.78306e-22	1.48512e-21	0.009535	1	0
GNAL	2774	broad.mit.edu	37	18	11752922	11752922	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:11752922C>A	uc010dkz.2	+	3	462	c.216C>A	c.(214-216)CCC>CCA	p.P72P	GNAL_uc002kqc.2_Silent_p.P149P|GNAL_uc002kqd.2_Silent_p.P72P	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	72					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						GGTTTAATCCCGAGTAAGAAT	0.428			NA											33	3					3.67414e-24	5.75834e-24	0.002445	1	0
MC5R	4161	broad.mit.edu	37	18	13826127	13826127	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:13826127G>T	uc010xaf.1	+	1	363	c.363G>T	c.(361-363)ATG>ATT	p.M121I		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	121	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						TTGACTCCATGATCTGCATTT	0.517			NA											91	13					2.36867e-37	4.11221e-37	0.00361	1	0
MC2R	4158	broad.mit.edu	37	18	13885081	13885081	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:13885081C>A	uc002ksp.1	-	2	614	c.437G>T	c.(436-438)CGC>CTC	p.R146L		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	146	Cytoplasmic (By similarity).		R -> H (in GCCD1).		G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	CACCACAGTGCGGCGCATGGT	0.577	Colon(141;1584 1782 35999 48227 48692)		NA											46	9					3.54909e-21	5.34991e-21	0.002852	1	0
POTEC	388468	broad.mit.edu	37	18	14542843	14542844	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:14542843_14542844CC>AA	uc010dln.2	-	1	756_757	c.302_303GG>TT	c.(301-303)TGG>TTT	p.W101F	POTEC_uc010xaj.1_RNA	NM_001137671	NP_001131143	B2RU33	POTEC_HUMAN	ANKRD26-like family B, member 2	101										skin(3)	3						AGTGACAGCACCACTTGCCCAT	0.619			NA											122	86					0	0	0.004672	0	0
LAMA3	3909	broad.mit.edu	37	18	21338378	21338378	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:21338378G>A	uc002kuq.2	+	7	1052	c.966G>A	c.(964-966)CAG>CAA	p.Q322Q	LAMA3_uc010dlv.1_Silent_p.Q322Q|LAMA3_uc002kur.2_Silent_p.Q322Q	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	322	Laminin EGF-like 1.|Domain V.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGAATGCCAGCACCACACCT	0.557			NA											30	3					0	0	0.009535	0	0
LAMA3	3909	broad.mit.edu	37	18	21426388	21426388	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:21426388G>T	uc002kuq.2	+	31	3933	c.3847G>T	c.(3847-3849)GGG>TGG	p.G1283W	LAMA3_uc002kur.2_Missense_Mutation_p.G1283W	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	1283	Laminin EGF-like 9.|Domain III B.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCCTGAGGGTGGGCAGTGCCC	0.657			NA											96	18					1.3009e-50	2.37577e-50	0.00361	1	0
PSMA8	143471	broad.mit.edu	37	18	23738084	23738084	+	Splice_Site	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:23738084A>T	uc002kvq.2	+	4	487	c.373_splice	c.e4-2	p.K125_splice	PSMA8_uc002kvo.2_Splice_Site_p.K81_splice|PSMA8_uc002kvp.2_Splice_Site_p.K119_splice|PSMA8_uc002kvr.2_Splice_Site_p.K93_splice	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1						anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			TTATTTTTCTAGAAATATACC	0.303			NA											50	4					0	0	0.00361	0	0
KCTD1	284252	broad.mit.edu	37	18	24039845	24039845	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:24039845C>A	uc002kvw.2	-	4	914	c.354G>T	c.(352-354)CAG>CAT	p.Q118H	KCTD1_uc010xbj.1_Missense_Mutation_p.Q726H|KCTD1_uc010xbk.1_Missense_Mutation_p.Q118H|KCTD1_uc002kvy.2_Missense_Mutation_p.Q36H	NM_001136205	NP_001129677	Q719H9	KCTD1_HUMAN	potassium channel tetramerisation domain	118					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|voltage-gated potassium channel complex	transcription corepressor activity|transcription factor binding|voltage-gated potassium channel activity			ovary(1)	1	all_cancers(21;0.00191)|Lung NSC(5;0.000698)|all_lung(6;0.0019)|Ovarian(20;0.0848)		Epithelial(2;7.8e-06)|OV - Ovarian serous cystadenocarcinoma(3;9.02e-06)|all cancers(3;3.37e-05)			ACAACATGGGCTGAAGCTGAA	0.438			NA											72	19					1.14856e-27	1.87295e-27	0.00361	1	0
DSG1	1828	broad.mit.edu	37	18	28916327	28916327	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:28916327A>G	uc002kwp.2	+	9	1228	c.1016A>G	c.(1015-1017)TAT>TGT	p.Y339C		NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	339	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CCCTTAGATTATGAAGCTATG	0.299			NA											11	4					0	0	0.001855	0	0
SETBP1	26040	broad.mit.edu	37	18	42530404	42530404	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:42530404G>T	uc010dni.2	+	4	1395	c.1099G>T	c.(1099-1101)GGG>TGG	p.G367W		NM_015559	NP_056374	Q9Y6X0	SETBP_HUMAN	SET binding protein 1 isoform a	367						nucleus	DNA binding			upper_aerodigestive_tract(2)|large_intestine(1)	3				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		CAATACAGAAGGGAAAAGGGA	0.448			NA							Schinzel-Giedion_syndrome				32	11					2.2171e-23	3.42756e-23	0.009535	1	0
MBD2	8932	broad.mit.edu	37	18	51686216	51686216	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:51686216T>C	uc002lfg.1	-	6	1396	c.1167A>G	c.(1165-1167)GCA>GCG	p.A389A		NM_003927	NP_003918	Q9UBB5	MBD2_HUMAN	methyl-CpG binding domain protein 2 isoform 1	389					transcription, DNA-dependent		C2H2 zinc finger domain binding|methyl-CpG binding|satellite DNA binding				0				Colorectal(16;0.0212)|READ - Rectum adenocarcinoma(32;0.188)	Hexobarbital(DB01355)	ACAAGATGTCTGCCATCAGTG	0.418			NA											31	6					0	0	0.002445	0	0
ALPK2	115701	broad.mit.edu	37	18	56246747	56246747	+	Missense_Mutation	SNP	C	C	A	rs150536488		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:56246747C>A	uc002lhj.3	-	4	1475	c.1261G>T	c.(1261-1263)GGT>TGT	p.G421C		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	421							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GATGAGGGACCGTGCTTGGAG	0.557			NA									OREG0025011	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	4					9.39024e-22	1.42773e-21	0.009718	1	0
ZNF532	55205	broad.mit.edu	37	18	56586262	56586262	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:56586262A>T	uc002lho.2	+	4	1290	c.743A>T	c.(742-744)AAG>ATG	p.K248M	ZNF532_uc002lhp.2_Missense_Mutation_p.K246M|ZNF532_uc010xeg.1_Missense_Mutation_p.K246M|ZNF532_uc002lhr.2_Missense_Mutation_p.K246M|ZNF532_uc002lhs.2_Missense_Mutation_p.K246M	NM_018181	NP_060651	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	248					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|skin(1)	2						AGCTCCGAGAAGAATGACACC	0.502			NA											33	8					0	0	0.002836	0	0
CDH20	28316	broad.mit.edu	37	18	59221904	59221904	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:59221904G>T	uc010dps.1	+	11	2394	c.2382G>T	c.(2380-2382)TCG>TCT	p.S794S	CDH20_uc002lif.2_Silent_p.S788S	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	794	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				ACGGGGCGTCGGAGGGACCCG	0.692			NA											5	0					0.000602214	0.000632636	0.000602	1	0
PIGN	23556	broad.mit.edu	37	18	59821857	59821857	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:59821857T>C	uc002lii.3	-	7	918	c.470A>G	c.(469-471)TAT>TGT	p.Y157C	PIGN_uc002lij.3_Missense_Mutation_p.Y157C	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	157	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups	p.Y157Y(1)		breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ATCATAACTATATGTATAAAC	0.313			NA											63	26					0	0	0.00361	0	0
SERPINB4	6318	broad.mit.edu	37	18	61306936	61306936	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:61306936A>T	uc002ljf.2	-	6	630	c.544T>A	c.(544-546)TTC>ATC	p.F182I	SERPINB4_uc002lje.2_Missense_Mutation_p.F182I|SERPINB4_uc002ljg.2_Intron	NM_002974	NP_002965	P48594	SPB4_HUMAN	serine (or cysteine) proteinase inhibitor, clade	182					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						TGCCCTTTGAAATAGATTGCG	0.313			NA											23	3					0	0	0.003954	0	0
SERPINB7	8710	broad.mit.edu	37	18	61465858	61465858	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:61465858G>T	uc002ljl.2	+	6	571	c.475G>T	c.(475-477)GGT>TGT	p.G159C	SERPINB7_uc002ljm.2_Missense_Mutation_p.G159C|SERPINB7_uc010xet.1_Missense_Mutation_p.G142C|SERPINB7_uc010dqg.2_Missense_Mutation_p.G159C	NM_001040147	NP_001035237	O75635	SPB7_HUMAN	serine (or cysteine) proteinase inhibitor, clade	159					regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			lung(2)|central_nervous_system(1)	3		Esophageal squamous(42;0.129)				GAACGTGATTGGTGAAGGTGG	0.333			NA											24	8					4.47668e-21	6.73766e-21	0.003954	1	0
SERPINB2	5055	broad.mit.edu	37	18	61569721	61569721	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:61569721A>T	uc010xeu.1	+	8	1095	c.762A>T	c.(760-762)CTA>CTT	p.L254L	SERPINB2_uc002ljo.2_Silent_p.L254L|SERPINB2_uc010dqh.2_Silent_p.L184L|SERPINB2_uc002ljp.1_Silent_p.L59L|SERPINB2_uc002ljq.1_Silent_p.L59L	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	254					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	CTCAGATTCTAGAACTCCCAT	0.413			NA											40	6					0	0	0.006999	0	0
ATP9B	374868	broad.mit.edu	37	18	77108132	77108132	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:77108132G>T	uc002lmx.2	+	25	2853	c.2839G>T	c.(2839-2841)GCT>TCT	p.A947S	ATP9B_uc002lmw.1_Missense_Mutation_p.A947S|ATP9B_uc002lmz.1_Missense_Mutation_p.A641S|ATP9B_uc002lna.2_Intron|ATP9B_uc002lnb.1_Intron|ATP9B_uc010drb.2_RNA	NM_198531	NP_940933	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	947	Helical; (Potential).				ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)	3		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CTCTCTCCAGGCTGTGTTTTC	0.567			NA											59	21					1.87469e-40	3.32019e-40	0.00361	1	0
MED16	10025	broad.mit.edu	37	19	877041	877041	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:877041C>A	uc002lqd.1	-	9	1644	c.1493G>T	c.(1492-1494)AGT>ATT	p.S498I	MED16_uc010drw.1_Missense_Mutation_p.S323I|MED16_uc002lqe.2_Missense_Mutation_p.S487I|MED16_uc002lqf.2_Missense_Mutation_p.S487I|MED16_uc010xfv.1_Intron|MED16_uc010xfw.1_Intron|MED16_uc010xfx.1_Missense_Mutation_p.S343I|MED16_uc010xfy.1_Intron	NM_005481	NP_005472	Q9Y2X0	MED16_HUMAN	mediator complex subunit 16	498					androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	receptor activity|thyroid hormone receptor binding|thyroid hormone receptor coactivator activity|vitamin D receptor binding				0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGTACCATACTGGGCTGCAC	0.677			NA											43	9					4.01765e-15	5.40344e-15	0.009718	1	0
TLE2	7089	broad.mit.edu	37	19	3009671	3009671	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:3009671G>A	uc002lww.2	-	13	1305	c.1042C>T	c.(1042-1044)CCC>TCC	p.P348S	TLE2_uc010xhb.1_Intron|TLE2_uc010dth.2_Missense_Mutation_p.P349S|TLE2_uc010xhc.1_Missense_Mutation_p.P226S|TLE2_uc010dti.2_Missense_Mutation_p.P362S|TLE2_uc010xhd.1_Missense_Mutation_p.P256S	NM_003260	NP_003251	Q04725	TLE2_HUMAN	transducin-like enhancer protein 2 isoform 1	348	Pro/Ser-rich.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTGAAGGGACTGGACAGA	0.652			NA											18	0					0	0	0.007413	0	0
FUT6	2528	broad.mit.edu	37	19	5832203	5832203	+	Missense_Mutation	SNP	G	G	A	rs111589452		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:5832203G>A	uc002mdf.1	-	4	902	c.376C>T	c.(376-378)CGG>TGG	p.R126W	FUT6_uc002mdg.1_Missense_Mutation_p.R126W|FUT6_uc002mdh.1_Missense_Mutation_p.R126W|FUT6_uc010dul.1_Missense_Mutation_p.R126W	NM_001040701	NP_001035791	P51993	FUT6_HUMAN	fucosyltransferase 6	126	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						TGCCCCTGCCGCCTCGGGGAG	0.617			NA											51	5					0	0	0.00361	0	0
C3	718	broad.mit.edu	37	19	6686289	6686289	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:6686289C>A	uc002mfm.2	-	29	3718	c.3656G>T	c.(3655-3657)CGC>CTC	p.R1219L	C3_uc002mfl.2_5'UTR	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1219					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GTCCTCCCAGCGGTTCTTATC	0.542			NA											36	83					8.73648e-17	1.21034e-16	0.004289	1	0
INSR	3643	broad.mit.edu	37	19	7166355	7166355	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:7166355C>A	uc002mgd.1	-	8	1780	c.1671G>T	c.(1669-1671)ACG>ACT	p.T557T	INSR_uc002mge.1_Silent_p.T557T|INSR_uc002mgf.2_Silent_p.T557T	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	557					activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGTCTACCACCGTCCAACTGT	0.552			NA											35	3					1.21669e-08	1.43919e-08	0.003271	1	0
ZNF358	140467	broad.mit.edu	37	19	7584982	7584982	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:7584982A>T	uc002mgn.2	+	2	1024	c.854A>T	c.(853-855)CAC>CTC	p.H285L	MCOLN1_uc010dvh.1_5'Flank|MCOLN1_uc002mgo.2_5'Flank|MCOLN1_uc002mgp.2_5'Flank	NM_018083	NP_060553	Q9NW07	ZN358_HUMAN	zinc finger protein 358	285	C2H2-type 5.				embryonic forelimb morphogenesis|neural tube development|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						CTGCGCACGCACACGGGCGAG	0.741			NA											6	9					0	0	0.001984	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841989	8841989	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:8841989C>A	uc010xkg.1	+	1	599	c.599C>A	c.(598-600)TCC>TAC	p.S200Y		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						ATGGCGCTGTCCACCTCAGGG	0.582			NA									OREG0007662	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=OR2Z1|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	89	11					2.00703e-41	3.56109e-41	0.00361	1	0
OR2Z1	284383	broad.mit.edu	37	19	8842092	8842092	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:8842092A>G	uc010xkg.1	+	1	702	c.702A>G	c.(700-702)AGA>AGG	p.R234R		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	234	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						AGGAGGCCAGACACAAGGCTG	0.587			NA											49	10					0	0	0.00361	0	0
MUC16	94025	broad.mit.edu	37	19	9060014	9060014	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:9060014G>T	uc002mkp.2	-	3	27636	c.27432C>A	c.(27430-27432)GCC>GCA	p.A9144A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9146	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGAGAAAGAGGCAGAGCTGG	0.493			NA											19	7					5.3912e-06	5.93431e-06	0.006122	1	0
MUC16	94025	broad.mit.edu	37	19	9067730	9067730	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:9067730C>T	uc002mkp.2	-	3	19920	c.19716G>A	c.(19714-19716)AAG>AAA	p.K6572K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	6574	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TAGTCGGTATCTTATGTGAGG	0.453			NA											56	14					0	0	0.00361	0	0
MUC16	94025	broad.mit.edu	37	19	9088057	9088057	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:9088057A>T	uc002mkp.2	-	1	3962	c.3758T>A	c.(3757-3759)CTC>CAC	p.L1253H		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1253	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGTGCTCCGAGGTGGATGCT	0.507			NA											354	78					0	0	0.00361	0	0
OR7D4	125958	broad.mit.edu	37	19	9325053	9325053	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:9325053C>A	uc002mla.1	-	1	461	c.461G>T	c.(460-462)TGG>TTG	p.W154L		NM_001005191	NP_001005191	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D,	154	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CAGGGAGAACCAGAAAATGAT	0.527			NA											50	11					2.24722e-20	3.3406e-20	0.00361	1	0
DNMT1	1786	broad.mit.edu	37	19	10254444	10254444	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:10254444G>A	uc002mng.2	-	28	3246	c.3066C>T	c.(3064-3066)TAC>TAT	p.Y1022Y	DNMT1_uc002mnf.2_5'UTR|DNMT1_uc010xlc.1_Silent_p.Y1038Y|DNMT1_uc002mnh.2_Silent_p.Y917Y|DNMT1_uc010xld.1_Silent_p.Y1022Y	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1022	BAH 2.				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CTGCTGACCTGTAGAACTTGT	0.512			NA											157	281					0	0	0.00361	0	0
FARSA	2193	broad.mit.edu	37	19	13039359	13039359	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:13039359G>A	uc002mvs.2	-	6	763	c.715C>T	c.(715-717)CTG>TTG	p.L239L	FARSA_uc002mvt.2_Intron|FARSA_uc010xmv.1_Silent_p.L208L|FARSA_uc010dyy.1_Silent_p.L160L	NM_004461	NP_004452	Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	239					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			ovary(1)	1					L-Phenylalanine(DB00120)	CCCATCTCCAGGAAGATCTGT	0.642			NA											14	5					0	0	0.00245	0	0
CACNA1A	773	broad.mit.edu	37	19	13323474	13323474	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:13323474G>T	uc010dze.2	-	41	6260	c.6024C>A	c.(6022-6024)CCC>CCA	p.P2008P	CACNA1A_uc010xnd.1_Silent_p.P713P|CACNA1A_uc002mwx.3_Silent_p.P713P|CACNA1A_uc010dzc.2_Silent_p.P1533P|CACNA1A_uc002mwy.3_Silent_p.P2007P|CACNA1A_uc002mwv.3_Silent_p.P524P	NM_001127221	NP_001120693	O00555	CAC1A_HUMAN	calcium channel, alpha 1A subunit isoform 3	2008	Cytoplasmic (Potential).				cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			large_intestine(2)	2			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCTGGGTGGAGGGGAGGGCGT	0.682			NA											6	2					8.12818e-05	8.70909e-05	0.001984	1	0
ZSWIM4	65249	broad.mit.edu	37	19	13919735	13919735	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:13919735G>A	uc002mxh.1	+	4	987	c.798G>A	c.(796-798)AAG>AAA	p.K266K	ZSWIM4_uc010xng.1_Silent_p.K72K	NM_023072	NP_075560	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	266							zinc ion binding			central_nervous_system(2)	2			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			AGCAGGTGAAGCAGCTACTGT	0.592			NA											4	10					0	0	0.009096	0	0
CLEC17A	388512	broad.mit.edu	37	19	14710863	14710863	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:14710863C>A	uc010dzn.1	+	12	840	c.763C>A	c.(763-765)CCT>ACT	p.P255T	CLEC17A_uc002mzh.1_Missense_Mutation_p.P238T|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Intron|CLEC17A_uc010dzo.1_Missense_Mutation_p.P255T			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	255	Extracellular (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						AATTACCTGTCCTGAAGGCTG	0.483			NA											33	12					4.34311e-12	5.48991e-12	0.003271	1	0
SYDE1	85360	broad.mit.edu	37	19	15220176	15220176	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:15220176G>C	uc002nah.1	+	2	429	c.398G>C	c.(397-399)GGC>GCC	p.G133A	SYDE1_uc002nai.1_Missense_Mutation_p.G66A|SYDE1_uc002naj.1_5'UTR	NM_033025	NP_149014	Q6ZW31	SYDE1_HUMAN	synapse defective 1, Rho GTPase, homolog 1	133	Pro-rich.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			ovary(1)|pancreas(1)	2						CCACAGCCTGGCTCAGCTGAG	0.647			NA											12	16					0	0	0.00245	0	0
CYP4F22	126410	broad.mit.edu	37	19	15636206	15636206	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:15636206G>C	uc002nbh.3	+	3	226	c.59G>C	c.(58-60)CGC>CCC	p.R20P		NM_173483	NP_775754	Q6NT55	CP4FN_HUMAN	cytochrome P450, family 4, subfamily F,	20						endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			ovary(1)|pancreas(1)	2						ACGGCGTTCCGCATATACGCG	0.622			NA											12	26					0	0	0.001368	0	0
CYP4F2	8529	broad.mit.edu	37	19	15996831	15996831	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:15996831C>G	uc002nbs.1	-	9	1068	c.1018G>C	c.(1018-1020)GTC>CTC	p.V340L	CYP4F2_uc010xot.1_Missense_Mutation_p.V191L|CYP4F2_uc010xou.1_Silent_p.G168G	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	340					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						TGGTACAGGACCCAGGAGAGA	0.597			NA											13	66					0	0	0.003163	0	0
UPF1	5976	broad.mit.edu	37	19	18965953	18965953	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:18965953G>T	uc002nkg.2	+	11	1754	c.1479G>T	c.(1477-1479)GTG>GTT	p.V493V	UPF1_uc002nkf.2_Silent_p.V482V	NM_002911	NP_002902	Q92900	RENT1_HUMAN	regulator of nonsense transcripts 1	493					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|protein binding|RNA binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TGAAGACTGTGCTGCAAAGAC	0.672			NA											32	11					6.00712e-18	8.55506e-18	0.002445	1	0
ZNF90	7643	broad.mit.edu	37	19	20229559	20229559	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:20229559G>A	uc002nor.2	+	4	1335	c.1196G>A	c.(1195-1197)TGT>TAT	p.C399Y	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	399	C2H2-type 9.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CCCTACAAATGTGAAGAATGT	0.358			NA											3	8					0	0	0.004672	0	0
ZNF431	170959	broad.mit.edu	37	19	21365467	21365467	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:21365467G>T	uc002npp.2	+	5	508	c.361G>T	c.(361-363)GAC>TAC	p.D121Y	ZNF431_uc010ecq.2_Missense_Mutation_p.D30Y|ZNF431_uc010ecr.2_Missense_Mutation_p.D122Y	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						GCCAGAGCAAGACATAAAAGA	0.323			NA											22	3					8.04996e-18	1.14307e-17	0.001882	1	0
ZNF676	163223	broad.mit.edu	37	19	22362994	22362994	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:22362994C>A	uc002nqs.1	-	3	1843	c.1525G>T	c.(1525-1527)GAA>TAA	p.E509*		NM_001001411	NP_001001411	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	509	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TTGCCACATTCTTCACATTTG	0.388			NA											13	26					1.61879e-10	1.98651e-10	0.001368	1	0
ATP4A	495	broad.mit.edu	37	19	36051513	36051513	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:36051513G>A	uc002oal.1	-	6	568	c.539C>T	c.(538-540)GCC>GTC	p.A180V	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	180	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GATGACAGTGGCTTGCTGCGG	0.622			NA											21	5					0	0	0.002299	0	0
NPHS1	4868	broad.mit.edu	37	19	36322197	36322197	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:36322197C>A	uc002oby.2	-	26	3387	c.3387_splice	c.e26+1	p.T1129_splice	NPHS1_uc010eem.1_Splice_Site	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor						cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCCCCACTTACCGTGGAGCTC	0.612			NA											48	12					1.61863e-15	2.19525e-15	0.00361	1	0
NPHS1	4868	broad.mit.edu	37	19	36338987	36338987	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:36338987A>G	uc002oby.2	-	11	1396	c.1396T>C	c.(1396-1398)TTG>CTG	p.L466L		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	466	Extracellular (Potential).|Ig-like C2-type 5.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CCGATAGCCAAACACACCAGC	0.652			NA											34	12					0	0	0.003755	0	0
RYR1	6261	broad.mit.edu	37	19	38939429	38939429	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:38939429G>A	uc002oit.2	+	11	1228	c.1098G>A	c.(1096-1098)CTG>CTA	p.L366L	RYR1_uc002oiu.2_Silent_p.L366L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	366	Cytoplasmic.|MIR 5.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCAAGGCCCTGCGGCTCGGCG	0.408			NA											32	5					0	0	0.002445	0	0
RYR1	6261	broad.mit.edu	37	19	38993190	38993190	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:38993190A>C	uc002oit.2	+	48	7788	c.7658A>C	c.(7657-7659)TAC>TCC	p.Y2553S	RYR1_uc002oiu.2_Missense_Mutation_p.Y2553S|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2553	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGAACCGCTACCTGTGCCTG	0.652			NA											23	2					0	0	0.00333	0	0
MAP3K10	4294	broad.mit.edu	37	19	40710509	40710509	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:40710509G>T	uc002ona.2	+	3	1269	c.981G>T	c.(979-981)ACG>ACT	p.T327T	MAP3K10_uc002onb.2_5'UTR	NM_002446	NP_002437	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase	327	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			ovary(2)|lung(2)|skin(1)|pancreas(1)	6						TTCCCTCCACGTGCCCCGAGC	0.672			NA											28	30					5.60225e-13	7.19439e-13	0.009535	1	0
C19orf47	126526	broad.mit.edu	37	19	40832386	40832386	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:40832386C>G	uc002oni.3	-	7	559	c.558G>C	c.(556-558)CTG>CTC	p.L186L	C19orf47_uc002ong.2_Silent_p.L45L|C19orf47_uc002onh.2_Silent_p.L119L	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	186										ovary(1)|skin(1)	2			Lung(22;0.000636)			CCCGGCGGGCCAGGGCTGCTG	0.597			NA											7	15					0	0	0.001984	0	0
SPTBN4	57731	broad.mit.edu	37	19	41009860	41009860	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:41009860G>A	uc002ony.2	+	12	1572	c.1486G>A	c.(1486-1488)GCA>ACA	p.A496T	SPTBN4_uc002onx.2_Missense_Mutation_p.A496T|SPTBN4_uc002onz.2_Missense_Mutation_p.A496T	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	496	Spectrin 3.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGGCATTGGCAGCCGAAGG	0.667			NA											38	8					0	0	0.00623	0	0
LTBP4	8425	broad.mit.edu	37	19	41135376	41135376	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:41135376C>G	uc002ooh.1	+	34	4796	c.4796C>G	c.(4795-4797)TCC>TGC	p.S1599C	LTBP4_uc002oog.1_Missense_Mutation_p.S1562C|LTBP4_uc002ooi.1_Missense_Mutation_p.S1532C|LTBP4_uc002ooj.1_Missense_Mutation_p.S472C|LTBP4_uc002ool.1_Missense_Mutation_p.S611C|LTBP4_uc010xvp.1_Missense_Mutation_p.S359C	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1599	EGF-like 16.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			ACGGATGGCTCCTTCCGCTGC	0.701			NA											22	22					0	0	0.001882	0	0
CYP2B6	1555	broad.mit.edu	37	19	41518391	41518391	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:41518391G>T	uc002opr.1	+	7	1159	c.1152_splice	c.e7+1	p.K384_splice	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Splice_Site_p.K184_splice	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,						cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	CATCCCCAAGGTAAGACCGGC	0.512			NA											42	10					4.67007e-22	7.12858e-22	0.00874	1	0
CYP2A13	1553	broad.mit.edu	37	19	41596345	41596345	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:41596345C>T	uc002opt.2	+	4	539	c.530C>T	c.(529-531)ACA>ATA	p.T177I		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	177					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	CTGAGCCGCACAGTCTCCAAT	0.552			NA											76	22					0	0	0.00361	0	0
PSG8	440533	broad.mit.edu	37	19	43258502	43258502	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:43258502A>G	uc002ouo.2	-	5	1324	c.1226T>C	c.(1225-1227)ATG>ACG	p.M409T	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG8_uc010eim.2_RNA|PSG8_uc002oui.2_Missense_Mutation_p.M248T|PSG8_uc002ouh.2_Missense_Mutation_p.M409T|PSG8_uc010ein.2_Missense_Mutation_p.M287T|PSG8_uc002ouj.3_Missense_Mutation_p.M191T|PSG8_uc002ouk.3_Missense_Mutation_p.M248T|PSG8_uc002oul.3_Missense_Mutation_p.M409T|PSG8_uc002oum.3_Missense_Mutation_p.M316T|PSG1_uc002oun.2_Intron|PSG8_uc002oup.3_Missense_Mutation_p.M316T	NM_182707	NP_874366	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8 isoform	409	Ig-like C2-type 3.					extracellular region					0		Prostate(69;0.00899)				TTTTACTGTCATGGATTTGGA	0.458			NA											211	48					0	0	0.00361	0	0
IRF2BP1	26145	broad.mit.edu	37	19	46388940	46388940	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:46388940G>T	uc002pds.1	-	1	437	c.93C>A	c.(91-93)GCC>GCA	p.A31A		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	31					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CGCGACACACGGCCTCGCTGA	0.697			NA											13	1					9.31168e-06	1.02091e-05	0.001855	1	0
ZC3H4	23211	broad.mit.edu	37	19	47589728	47589728	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:47589728C>T	uc002pga.3	-	6	821	c.783G>A	c.(781-783)ATG>ATA	p.M261I	ZC3H4_uc002pgb.1_Intron	NM_015168	NP_055983	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	261	Gly-rich.						nucleic acid binding|zinc ion binding			skin(4)|ovary(2)	6		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		TGCCCCTGCCCATGCCGCGGC	0.647			NA											35	6					0	0	0.004289	0	0
SULT2A1	6822	broad.mit.edu	37	19	48382354	48382354	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:48382354C>T	uc002phr.2	-	4	646	c.506G>A	c.(505-507)GGC>GAC	p.G169D		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	169					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		GGGCATCCAGCCATGAATGTG	0.438			NA											50	72					0	0	0.00361	0	0
RPL13A	23521	broad.mit.edu	37	19	49993753	49993753	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:49993753G>T	uc002pny.2	+	4	198	c.176G>T	c.(175-177)CGC>CTC	p.R59L	RPL13A_uc002pnz.2_5'UTR|RPL13A_uc002poa.2_Missense_Mutation_p.R49L|SNORD33_uc010emz.1_5'Flank|SNORD34_uc010ena.1_5'Flank|SNORD35A_uc010enb.1_5'Flank	NM_012423	NP_036555	P40429	RL13A_HUMAN	ribosomal protein L13a	59					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|large ribosomal subunit	structural constituent of ribosome				0		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00154)|GBM - Glioblastoma multiforme(486;0.0246)		GCTTTCCTCCGCAAGCGGATG	0.627			NA											42	9					6.31075e-24	9.86661e-24	0.00361	1	0
CPT1C	126129	broad.mit.edu	37	19	50208355	50208355	+	Missense_Mutation	SNP	G	G	T	rs143361095		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:50208355G>T	uc002ppj.2	+	8	1068	c.863G>T	c.(862-864)CGC>CTC	p.R288L	CPT1C_uc002ppl.3_Missense_Mutation_p.R254L|CPT1C_uc002ppi.2_Missense_Mutation_p.R205L|CPT1C_uc002ppk.2_Missense_Mutation_p.R277L|CPT1C_uc010eng.2_Missense_Mutation_p.R288L|CPT1C_uc010enh.2_Missense_Mutation_p.R288L|CPT1C_uc010ybc.1_Missense_Mutation_p.R126L|CPT1C_uc010eni.1_5'Flank	NM_152359	NP_689572	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C isoform 2	288	Cytoplasmic (Potential).				fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CGCCTGAACCGCCAGGAGATA	0.662			NA											67	11					9.12251e-31	1.52885e-30	0.00361	1	0
KLK2	3817	broad.mit.edu	37	19	51379992	51379992	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:51379992G>T	uc002ptv.2	+	3	512	c.471G>T	c.(469-471)TGG>TGT	p.W157C	KLK2_uc010eog.2_Missense_Mutation_p.W55C|KLK2_uc010yck.1_Missense_Mutation_p.W157C|KLK2_uc002ptu.2_Missense_Mutation_p.W157C|KLK2_uc002ptt.2_RNA|KLK2_uc010ycl.1_Missense_Mutation_p.W140C|KLK2_uc010ycm.1_Missense_Mutation_p.W55C|KLK2_uc010eoh.2_Missense_Mutation_p.W55C	NM_005551	NP_005542	P20151	KLK2_HUMAN	kallikrein 2, prostatic isoform 1	157	Peptidase S1.				proteolysis		serine-type endopeptidase activity			ovary(1)|skin(1)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		CCTCAGGCTGGGGCAGCATCG	0.637			NA	T	ETV4	prostate								26	19					4.4004e-07	4.97101e-07	0.00333	1	0
KLK10	5655	broad.mit.edu	37	19	51518109	51518109	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:51518109T>A	uc002puy.2	-	6	859	c.778A>T	c.(778-780)ACC>TCC	p.T260S	KLK10_uc002puz.2_Missense_Mutation_p.T260S|KLK10_uc002pva.2_Missense_Mutation_p.T260S	NM_145888	NP_665895	O43240	KLK10_HUMAN	kallikrein-related peptidase 10 preproprotein	260	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			lung(2)	2		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		CAGATCTGGGTGTAGACAGCT	0.542			NA											23	72					0	0	0.00278	0	0
C19orf75	284369	broad.mit.edu	37	19	51770667	51770667	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:51770667G>A	uc002pwb.1	+	5	832	c.451G>A	c.(451-453)GCG>ACG	p.A151T	C19orf75_uc010eov.1_RNA|C19orf75_uc010ycw.1_Missense_Mutation_p.A57T	NM_173635	NP_775906	Q8N7X8	CS075_HUMAN	hypothetical protein LOC284369	151						integral to membrane				ovary(1)|pancreas(1)	2						GAAAGCTGCAGCGATCAGAGC	0.473			NA											37	92					0	0	0.003271	0	0
CEACAM18	729767	broad.mit.edu	37	19	51983828	51983828	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:51983828C>T	uc002pwv.1	+	3	477	c.477C>T	c.(475-477)GGC>GGT	p.G159G		NM_001080405	NP_001073874	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion	159						integral to membrane				skin(1)	1		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ACAGAGAAGGCAGCCTGTTGA	0.562			NA											30	20					0	0	0.007291	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034179	52034179	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:52034179C>T	uc002pwy.2	-	3	624	c.462G>A	c.(460-462)GGG>GGA	p.G154G	SIGLEC6_uc002pwz.2_Silent_p.G154G|SIGLEC6_uc002pxa.2_Silent_p.G154G|SIGLEC6_uc010ydb.1_Silent_p.G107G|SIGLEC6_uc010ydc.1_Silent_p.G143G|SIGLEC6_uc010eoz.1_Silent_p.G132G|SIGLEC6_uc010epb.1_Silent_p.G107G|SIGLEC6_uc010epa.1_Silent_p.G143G	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	154	Ig-like C2-type 1.|Extracellular (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		ACTCCAGGGTCCCTGGGATGG	0.637			NA											79	64					0	0	0.00361	0	0
ZNF577	84765	broad.mit.edu	37	19	52376688	52376688	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:52376688G>T	uc010yde.1	-	7	946	c.555C>A	c.(553-555)CCC>CCA	p.P185P	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Silent_p.P126P|ZNF577_uc002pxv.2_Silent_p.P178P|ZNF577_uc002pxw.2_Silent_p.P119P	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CACATCCATGGGGTTTCTCTC	0.478			NA											60	46					1.19553e-41	2.12319e-41	0.00361	1	0
ZNF578	147660	broad.mit.edu	37	19	53014061	53014061	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:53014061G>T	uc002pzp.3	+	6	671	c.427G>T	c.(427-429)GAT>TAT	p.D143Y		NM_001099694	NP_001093164	Q96N58	ZN578_HUMAN	zinc finger protein 578	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		AGACCGACATGATCAAAGGCA	0.393			NA											103	69					6.21867e-57	1.14651e-56	0.00361	1	0
VN1R2	317701	broad.mit.edu	37	19	53762072	53762072	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:53762072G>T	uc002qbi.2	+	1	528	c.444G>T	c.(442-444)ATG>ATT	p.M148I		NM_173856	NP_776255	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	148	Extracellular (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity				0				GBM - Glioblastoma multiforme(134;0.00301)		CAGAGACCATGGCAACTTTTG	0.438			NA											22	48					1.10923e-09	1.33494e-09	0.00278	1	0
CACNG6	59285	broad.mit.edu	37	19	54515347	54515347	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:54515347G>T	uc002qct.2	+	4	1277	c.687G>T	c.(685-687)CTG>CTT	p.L229L	CACNG6_uc002qcu.2_Silent_p.L183L|CACNG6_uc002qcv.2_Silent_p.L158L	NM_145814	NP_665813	Q9BXT2	CCG6_HUMAN	voltage-dependent calcium channel gamma-6	229	Helical; (Potential).					voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(2)	2	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		GGGCCGGCCTGATCCTGCTGT	0.716			NA											23	74					5.35356e-11	6.63704e-11	0.00278	1	0
PRPF31	26121	broad.mit.edu	37	19	54621832	54621832	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:54621832G>C	uc002qdh.2	+	2	570	c.174G>C	c.(172-174)AAG>AAC	p.K58N	TFPT_uc010yej.1_5'Flank|TFPT_uc010erd.2_5'Flank|PRPF31_uc010yek.1_Missense_Mutation_p.K58N	NM_015629	NP_056444	Q8WWY3	PRP31_HUMAN	pre-mRNA processing factor 31 homolog	58					assembly of spliceosomal tri-snRNP	Cajal body|MLL1 complex|nuclear speck|U4 snRNP|U4/U6 x U5 tri-snRNP complex|U4atac snRNP	RNA binding|snRNP binding			ovary(1)	1	all_cancers(19;0.00681)|all_epithelial(19;0.00362)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GGGATAGTAAGATGGTAAGAG	0.398			NA											59	114					0	0	0.00361	0	0
LILRB2	10288	broad.mit.edu	37	19	54782228	54782228	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:54782228G>A	uc002qfb.2	-	7	1410	c.1144C>T	c.(1144-1146)CCC>TCC	p.P382S	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.P382S|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.P382S|LILRB2_uc010yet.1_Missense_Mutation_p.P266S|LILRB2_uc010yeu.1_RNA	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	382	Extracellular (Potential).|Ig-like C2-type 4.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGACTCATGGGGAATTCAGCC	0.582			NA											109	76					0	0	0.00361	0	0
NLRP7	199713	broad.mit.edu	37	19	55451566	55451566	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:55451566C>A	uc002qih.3	-	4	697	c.621G>T	c.(619-621)GCG>GCT	p.A207A	NLRP7_uc002qig.3_Silent_p.A207A|NLRP7_uc002qii.3_Silent_p.A207A|NLRP7_uc010esk.2_Silent_p.A207A|NLRP7_uc010esl.2_Silent_p.A235A	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	207	NACHT.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		TGAGGTAGAACGCGTATCTGA	0.582			NA											38	30					3.33393e-15	4.49953e-15	0.004878	1	0
NLRP2	55655	broad.mit.edu	37	19	55493576	55493576	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:55493576G>C	uc002qij.2	+	6	596	c.510G>C	c.(508-510)GAG>GAC	p.E170D	NLRP2_uc010yfp.1_Missense_Mutation_p.E147D|NLRP2_uc010esn.2_Missense_Mutation_p.E146D|NLRP2_uc010eso.2_Missense_Mutation_p.E167D|NLRP2_uc010esp.2_Missense_Mutation_p.E148D	NM_017852	NP_060322	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	170					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		AGTTCCGGGAGATGTGGAAGA	0.502			NA											78	196					0	0	0.00361	0	0
NLRP13	126204	broad.mit.edu	37	19	56443530	56443530	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:56443530C>A	uc010ygg.1	-	1	173	c.148G>T	c.(148-150)GGG>TGG	p.G50W		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	50	DAPIN.						ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GGGAAGTGCCCCTGGGGGGCC	0.547			NA											51	49					1.56793e-16	2.16443e-16	0.00361	1	0
NLRP8	126205	broad.mit.edu	37	19	56487608	56487608	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:56487608G>A	uc002qmh.2	+	8	2886	c.2815G>A	c.(2815-2817)GAT>AAT	p.D939N	NLRP8_uc010etg.2_Missense_Mutation_p.D920N	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	939	LRR 5.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCTGAAGGATGATGGGGTGAT	0.468			NA											41	79					0	0	0.009718	0	0
NLRP5	126206	broad.mit.edu	37	19	56544100	56544100	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:56544100C>A	uc002qmj.2	+	8	2400	c.2400C>A	c.(2398-2400)ACC>ACA	p.T800T	NLRP5_uc002qmi.2_Silent_p.T781T	NM_153447	NP_703148	P59047	NALP5_HUMAN	NACHT, LRR and PYD containing protein 5	800	LRR 3.					mitochondrion|nucleolus	ATP binding			ovary(3)|skin(2)|kidney(1)|central_nervous_system(1)	7		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CCATGAAGACCCTGTGTGCCA	0.607			NA											48	58					3.16986e-14	4.16758e-14	0.00361	1	0
PEG3	5178	broad.mit.edu	37	19	57325401	57325401	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:57325401C>G	uc002qnu.2	-	7	4760	c.4409G>C	c.(4408-4410)GGA>GCA	p.G1470A	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.G1441A|PEG3_uc002qnv.2_Missense_Mutation_p.G1470A|PEG3_uc002qnw.2_Missense_Mutation_p.G1346A|PEG3_uc002qnx.2_Missense_Mutation_p.G1344A|PEG3_uc010etr.2_Missense_Mutation_p.G1470A	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	1470	Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TTCAGCTTTTCCCTCTGGCTC	0.527			NA											54	134					0	0	0.00361	0	0
ZIM3	114026	broad.mit.edu	37	19	57646867	57646867	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:57646867G>T	uc002qnz.1	-	5	1224	c.838C>A	c.(838-840)CAG>AAG	p.Q280K		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	280	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TCATTACACTGATAGGATTTC	0.378			NA											56	42					1.11015e-26	1.79368e-26	0.00361	1	0
ZNF304	57343	broad.mit.edu	37	19	57868146	57868146	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:57868146A>T	uc010ygw.1	+	3	1297	c.909A>T	c.(907-909)GGA>GGT	p.G303G	ZNF304_uc010etw.2_Silent_p.G350G|ZNF304_uc010etx.2_Silent_p.G261G	NM_020657	NP_065708	Q9HCX3	ZN304_HUMAN	zinc finger protein 304	303					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		TTCACACTGGAAAAAGACACT	0.428			NA											17	49					0	0	0.008871	0	0
ZNF548	147694	broad.mit.edu	37	19	57910682	57910682	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:57910682G>T	uc002qom.2	+	3	1277	c.1027G>T	c.(1027-1029)GGG>TGG	p.G343W	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.G346W	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	343	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAATGATTGTGGGAAATTTTT	0.408			NA											17	44					3.45872e-05	3.74953e-05	0.004007	1	0
ZNF256	10172	broad.mit.edu	37	19	58453766	58453766	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:58453766T>A	uc002qqu.2	-	3	645	c.410A>T	c.(409-411)CAG>CTG	p.Q137L	ZNF256_uc010euj.2_5'UTR	NM_005773	NP_005764	Q9Y2P7	ZN256_HUMAN	zinc finger protein 256	137					multicellular organismal development|negative regulation of transcription, DNA-dependent	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			upper_aerodigestive_tract(1)|skin(1)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0155)		ATGCTGCTTCTGGTGCTGATG	0.458	NSCLC(55;1313 1552 8040 11996)		NA											64	65					0	0	0.00361	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58551820	58551820	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:58551820C>A	uc002qrc.1	+	4	620	c.373C>A	c.(373-375)CTG>ATG	p.L125M		NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	125					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CCGCACAGTTCTGGTATCTCT	0.587			NA											50	121					2.47907e-22	3.79613e-22	0.00361	1	0
SLC27A5	10998	broad.mit.edu	37	19	59021368	59021368	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:59021368G>A	uc002qtc.2	-	3	1013	c.903C>T	c.(901-903)CTC>CTT	p.L301L		NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	301	Cytoplasmic (Probable).|AMP (Potential).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CTGGCTTCGGGAGGCCTTGGG	0.577			NA											10	47					0	0	0.008291	0	0
TPO	7173	broad.mit.edu	37	2	1460007	1460007	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:1460007G>T	uc002qww.2	+	7	863	c.772G>T	c.(772-774)GAC>TAC	p.D258Y	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Missense_Mutation_p.D258Y|TPO_uc002qwr.2_Missense_Mutation_p.D258Y|TPO_uc002qwx.2_Missense_Mutation_p.D258Y|TPO_uc010yio.1_Missense_Mutation_p.D258Y|TPO_uc010yip.1_Missense_Mutation_p.D258Y	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	258	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGGAGGGGCTGACTGCCAGAT	0.463			NA											19	11					3.51602e-12	4.46779e-12	0.008871	1	0
ALLC	55821	broad.mit.edu	37	2	3743442	3743442	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:3743442G>T	uc010ewt.2	+	8	808	c.647G>T	c.(646-648)GGG>GTG	p.G216V	ALLC_uc002qyf.2_5'UTR	NM_018436	NP_060906	Q8N6M5	ALLC_HUMAN	allantoicase isoform a	235							allantoicase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		GCTAAGTTTGGGCACCCAAAC	0.443			NA								HNSCC(21;0.051)			14	20					4.36969e-10	5.31174e-10	0.001855	1	0
KCNF1	3754	broad.mit.edu	37	2	11052723	11052723	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:11052723T>A	uc002rax.2	+	1	661	c.171T>A	c.(169-171)GCT>GCA	p.A57A		NM_002236	NP_002227	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F,	57	Cytoplasmic (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		ACTGCTTGGCTGGGGGCTACG	0.622			NA											7	31					0	0	0.001984	0	0
NTSR2	23620	broad.mit.edu	37	2	11809768	11809768	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:11809768G>A	uc002rbq.3	-	1	562	c.488C>T	c.(487-489)TCG>TTG	p.S163L		NM_012344	NP_036476	O95665	NTR2_HUMAN	neurotensin receptor 2	163	Helical; Name=4; (Potential).				sensory perception	integral to plasma membrane					0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	GAGGCCGAGCGAGGCGGCCCA	0.746			NA											3	10					0	0	0.004672	0	0
TRIB2	28951	broad.mit.edu	37	2	12880825	12880825	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:12880825A>T	uc002rbv.3	+	3	2373	c.937A>T	c.(937-939)AGC>TGC	p.S313C	TRIB2_uc010yjp.1_Missense_Mutation_p.S177C	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	313					negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TACAGATTTTAGCGTCTCGAA	0.517			NA											38	23					0	0	0.007835	0	0
NBAS	51594	broad.mit.edu	37	2	15493719	15493719	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:15493719G>T	uc002rcc.1	-	34	4073	c.4047C>A	c.(4045-4047)AGC>AGA	p.S1349R	NBAS_uc010exl.1_Missense_Mutation_p.S421R|NBAS_uc002rcd.1_RNA	NM_015909	NP_056993	A2RRP1	NBAS_HUMAN	neuroblastoma-amplified protein	1349										ovary(2)|liver(1)|skin(1)	4						GAAGTTCAATGCTGCTAGGAG	0.473			NA											47	105					1.57945e-13	2.05425e-13	0.002852	1	0
WDR35	57539	broad.mit.edu	37	2	20173368	20173368	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:20173368C>A	uc002rdi.2	-	8	946	c.838G>T	c.(838-840)GAC>TAC	p.D280Y	WDR35_uc002rdj.2_Missense_Mutation_p.D280Y|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_5'UTR	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	280										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACATCTTTGTCCTGCATGGCT	0.453			NA											12	48					4.3838e-07	4.96386e-07	0.001855	1	0
PUM2	23369	broad.mit.edu	37	2	20482713	20482713	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:20482713G>A	uc002rds.1	-	11	1738	c.1715C>T	c.(1714-1716)TCA>TTA	p.S572L	PUM2_uc002rdt.1_Missense_Mutation_p.S572L|PUM2_uc002rdr.2_Missense_Mutation_p.S511L|PUM2_uc010yjy.1_Missense_Mutation_p.S572L|PUM2_uc002rdu.1_Missense_Mutation_p.S572L|PUM2_uc010yjz.1_Missense_Mutation_p.S511L	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	572	Ser-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTACCTGATGAACCAAATCC	0.408			NA											17	27					0	0	0.006122	0	0
C2orf43	60526	broad.mit.edu	37	2	20990127	20990127	+	Silent	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:20990127T>G	uc002rec.2	-	3	219	c.186A>C	c.(184-186)CCA>CCC	p.P62P	C2orf43_uc002rea.1_Silent_p.P62P|C2orf43_uc002reb.1_RNA|C2orf43_uc010yka.1_Intron|C2orf43_uc010ykb.1_5'UTR|C2orf43_uc010ykc.1_Intron|C2orf43_uc010ykd.1_Silent_p.P62P|C2orf43_uc010yke.1_Intron|C2orf43_uc010ykf.1_Intron	NM_021925	NP_068744	Q9H6V9	CB043_HUMAN	hypothetical protein LOC60526	62											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTTGCAAATGGCACATAAA	0.408			NA											16	79					0	0	0.00499	0	0
APOB	338	broad.mit.edu	37	2	21228598	21228598	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:21228598G>T	uc002red.2	-	26	11270	c.11142C>A	c.(11140-11142)CCC>CCA	p.P3714P		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3714					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATAGCCATTGGGGTTTTTGG	0.403			NA											50	28					3.86361e-14	5.06934e-14	0.00361	1	0
APOB	338	broad.mit.edu	37	2	21230918	21230918	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:21230918G>A	uc002red.2	-	26	8950	c.8822C>T	c.(8821-8823)ACA>ATA	p.T2941I		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2941					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGATTCATGTGTTCCCTCATC	0.438			NA											92	73					0	0	0.00361	0	0
ITSN2	50618	broad.mit.edu	37	2	24522911	24522911	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:24522911C>A	uc002rfe.2	-	12	1469	c.1211G>T	c.(1210-1212)TGG>TTG	p.W404L	ITSN2_uc002rff.2_Missense_Mutation_p.W404L|ITSN2_uc002rfg.2_Missense_Mutation_p.W404L|ITSN2_uc010eyd.2_Missense_Mutation_p.W429L	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	404	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTTCGTTCCCACTCTTCCTT	0.453			NA											40	143					3.43241e-23	5.29369e-23	0.009718	1	0
ADCY3	109	broad.mit.edu	37	2	25064493	25064493	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:25064493C>A	uc002rfs.3	-	4	1199	c.1000G>T	c.(1000-1002)GCC>TCC	p.A334S	ADCY3_uc002rfr.3_5'UTR|ADCY3_uc010ykm.1_Missense_Mutation_p.A334S	NM_004036	NP_004027	O60266	ADCY3_HUMAN	adenylate cyclase 3	334					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding			breast(3)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					GCACTGCAGGCAGAAGACAGC	0.622			NA											6	30					8.12818e-05	8.70909e-05	0.001984	1	0
CGREF1	10669	broad.mit.edu	37	2	27322662	27322662	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:27322662G>T	uc010ylf.1	-	7	961	c.329C>A	c.(328-330)CCG>CAG	p.P110Q	KHK_uc002ril.2_3'UTR|KHK_uc002rim.2_3'UTR|KHK_uc002rin.2_3'UTR|KHK_uc002rio.2_3'UTR|CGREF1_uc002rip.1_3'UTR			Q99674	CGRE1_HUMAN	SubName: Full=cDNA FLJ60367, weakly similar to Cell growth regulator with EF hand domain 1;	208					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTACCATTGCGGCTGCATCGC	0.622			NA											10	11					0.00621372	0.00637862	0.006214	1	0
SLC5A6	8884	broad.mit.edu	37	2	27430140	27430140	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:27430140T>A	uc002rjd.2	-	3	770	c.379A>T	c.(379-381)ACC>TCC	p.T127S	SLC5A6_uc010eyv.1_Missense_Mutation_p.T127S|SLC5A6_uc002rje.1_Missense_Mutation_p.T127S	NM_021095	NP_066918	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium-dependent	127					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	TAGGCACTGGTGAGATGCAGG	0.577			NA											15	35					0	0	0.003163	0	0
IFT172	26160	broad.mit.edu	37	2	27699522	27699522	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:27699522T>C	uc002rku.2	-	14	1448	c.1397A>G	c.(1396-1398)AAG>AGG	p.K466R	IFT172_uc002rkw.2_Missense_Mutation_p.K466R|IFT172_uc010yls.1_Missense_Mutation_p.K445R|IFT172_uc010ezc.2_Missense_Mutation_p.K466R|IFT172_uc002rkv.2_Missense_Mutation_p.K440R	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	466					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					AGCAATAGTCTTAATATCAAT	0.348			NA											24	52					0	0	0.005443	0	0
ALK	238	broad.mit.edu	37	2	29443605	29443605	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:29443605G>C	uc002rmy.2	-	23	4519	c.3612C>G	c.(3610-3612)CTC>CTG	p.L1204L	ALK_uc010ymo.1_Silent_p.L136L	NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	1204	Protein kinase.|Cytoplasmic (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GGAAGGACTTGAGGTCTCCCC	0.587			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				11	17					0	0	0.001368	0	0
ALK	238	broad.mit.edu	37	2	29474108	29474108	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:29474108C>A	uc002rmy.2	-	12	2974	c.2067G>T	c.(2065-2067)GGG>GGT	p.G689G		NM_004304	NP_004295	Q9UM73	ALK_HUMAN	anaplastic lymphoma kinase precursor	689	Extracellular (Potential).				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		NPM1/ALK(632)|EML4/ALK(246)|CLTC/ALK(44)|TPM3/ALK(33)|ATIC/ALK(24)|RANBP2/ALK(16)|TPM4/ALK(12)|TFG/ALK(7)|MSN/ALK(6)|CARS/ALK(5)|VCL/ALK(4)|KIF5B/ALK(4)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|SQSTM1/ALK(2)	haematopoietic_and_lymphoid_tissue(726)|lung(262)|autonomic_ganglia(148)|soft_tissue(61)|breast(4)|kidney(4)|large_intestine(3)|skin(3)|ovary(3)|thyroid(2)|central_nervous_system(1)|pancreas(1)	1218	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCCCGCTGGCCCCACATGTGG	0.657			NA	T|Mis|A	NPM1|TPM3|TFG|TPM4|ATIC|CLTC|MSN|ALO17|CARS|EML4	ALCL|NSCLC|Neuroblastoma	neuroblastoma			Neuroblastoma_Familial_Clustering_of|Congenital_Central_Hypoventilation_Syndrome				15	21					6.31663e-08	7.33275e-08	0.003163	1	0
NLRC4	58484	broad.mit.edu	37	2	32474721	32474722	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:32474721_32474722GG>TT	uc002roi.2	-	4	2457_2458	c.2211_2212CC>AA	c.(2209-2214)AACCTG>AAAATG	p.737_738NL>KM	NLRC4_uc002roj.1_Missense_Mutation_p.737_738NL>KM|NLRC4_uc010ezt.1_Intron	NM_021209	NP_067032	Q9NPP4	NLRC4_HUMAN	caspase recruitment domain protein 12	737_738	LRR 5.				activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			ovary(3)|large_intestine(1)|lung(1)|skin(1)	6	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AAGGTTTTCAGGTTTGTTACAG	0.396			NA											60	117					0	0	0.004672	0	0
LTBP1	4052	broad.mit.edu	37	2	33246008	33246008	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:33246008A>T	uc002ros.2	+	3	598	c.598A>T	c.(598-600)ATG>TTG	p.M200L		NM_206943	NP_996826	Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding	200	EGF-like 1.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|central_nervous_system(1)	8	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				GAATGGAGGGATGTGTCTCCG	0.493			NA											76	206					0	0	0.00361	0	0
SULT6B1	391365	broad.mit.edu	37	2	37406604	37406604	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:37406604G>T	uc002rpu.2	-	4	433	c.412C>A	c.(412-414)CAA>AAA	p.Q138K	SULT6B1_uc010yni.1_RNA	NM_001032377	NP_001027549	Q6IMI4	ST6B1_HUMAN	sulfotransferase family, cytosolic, 6B, member	176						cytoplasm	sulfotransferase activity			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(82;0.248)				GCCATACCTTGTCCTTTCATG	0.373			NA											32	38					4.3181e-19	6.26967e-19	0.002836	1	0
Unknown	0	broad.mit.edu	37	2	38709678	38709678	+	Silent	SNP	C	C	T	rs148735877	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:38709678C>T	uc002rqu.1	+	2	568	c.501C>T	c.(499-501)GAC>GAT	p.D167D						SubName: Full=RPLP0 protein;												NA						TGTCTGCAGACTGGCTACCCA	0.512			NA											4	47					0	0	0.000602	0	0
ABCG8	64241	broad.mit.edu	37	2	44100976	44100976	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:44100976G>C	uc002rtq.2	+	9	1352	c.1262G>C	c.(1261-1263)GGG>GCG	p.G421A	ABCG8_uc010yoa.1_Missense_Mutation_p.G420A	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	421	Helical; Name=1; (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTCATCCATGGGGCGGAGGCC	0.502			NA											89	117					0	0	0.00361	0	0
PPM1B	5495	broad.mit.edu	37	2	44457644	44457644	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:44457644A>T	uc002rtt.2	+	6	1655	c.1227A>T	c.(1225-1227)CAA>CAT	p.Q409H	PPM1B_uc002rtu.2_3'UTR|PPM1B_uc002rtv.2_Missense_Mutation_p.Q122H|PPM1B_uc002rtw.2_Intron|PPM1B_uc002rtx.2_Intron	NM_002706	NP_002697	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 1	409					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACTACCGACAACTTCTGGAGG	0.468			NA											38	36					0	0	0.003755	0	0
SIX3	6496	broad.mit.edu	37	2	45169558	45169558	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:45169558C>G	uc002run.1	+	1	522	c.315C>G	c.(313-315)ATC>ATG	p.I105M		NM_005413	NP_005404	O95343	SIX3_HUMAN	SIX homeobox 3	105			I -> V (in HPE2).		visual perception	nucleus					0		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CGGGCGACATCGAGCGGCTGG	0.697			NA											24	8					0	0	0.00333	0	0
FSHR	2492	broad.mit.edu	37	2	49190604	49190604	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:49190604G>T	uc002rww.2	-	10	1430	c.1356C>A	c.(1354-1356)GCC>GCA	p.A452A	FSHR_uc002rwx.2_Silent_p.A390A|FSHR_uc010fbn.2_Silent_p.A426A	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	452	Helical; Name=3; (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	ACAGCTCACTGGCAAAGACAG	0.507			NA							Gonadal_Dysgenesis_46_XX				12	35					0.00010058	0.000107352	0.001368	1	0
FSHR	2492	broad.mit.edu	37	2	49381474	49381474	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:49381474C>A	uc002rww.2	-	1	157	c.83G>T	c.(82-84)AGG>ATG	p.R28M	FSHR_uc002rwx.2_Missense_Mutation_p.R28M|FSHR_uc010fbn.2_Missense_Mutation_p.R28M|FSHR_uc010fbo.1_RNA	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	28	LRRNT.|Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GAGAAAAACCCTGTTAGAGCA	0.512			NA							Gonadal_Dysgenesis_46_XX				19	24					1.33834e-09	1.60767e-09	0.007413	1	0
NRXN1	9378	broad.mit.edu	37	2	50170875	50170875	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:50170875T>A	uc010fbp.2	-	5	1795	c.988A>T	c.(988-990)ATT>TTT	p.I330F	NRXN1_uc002rxb.3_Missense_Mutation_p.I1067F|NRXN1_uc010fbq.2_Missense_Mutation_p.I1435F|NRXN1_uc002rxe.3_Missense_Mutation_p.I1365F|NRXN1_uc010yon.1_Missense_Mutation_p.I30F|NRXN1_uc002rxa.3_Missense_Mutation_p.I30F	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	330	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CAGGGGTCAATGTCCTCATCA	0.423			NA											8	7					0	0	0.008291	0	0
NRXN1	9378	broad.mit.edu	37	2	50318579	50318579	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:50318579A>G	uc010fbp.2	-	3	1302	c.495T>C	c.(493-495)ATT>ATC	p.I165I	NRXN1_uc002rxb.3_Silent_p.I872I|NRXN1_uc010fbq.2_Silent_p.I1240I|NRXN1_uc002rxe.3_Silent_p.I1200I	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	165	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGGATTCTTCAATGGCGATGT	0.438			NA											50	55					0	0	0.00361	0	0
NRXN1	9378	broad.mit.edu	37	2	50318602	50318602	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:50318602C>A	uc010fbp.2	-	3	1279	c.472G>T	c.(472-474)GTT>TTT	p.V158F	NRXN1_uc002rxb.3_Missense_Mutation_p.V865F|NRXN1_uc010fbq.2_Missense_Mutation_p.V1233F|NRXN1_uc002rxe.3_Missense_Mutation_p.V1193F	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	158	Extracellular (Potential).|Laminin G-like.			V -> I (in Ref. 1; AF064842).	angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCTGTCCCAACATTAAACTTA	0.388			NA											25	62					7.92952e-12	9.99719e-12	0.003954	1	0
NRXN1	9378	broad.mit.edu	37	2	50779845	50779845	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:50779845C>A	uc010fbq.2	-	9	3236	c.1759G>T	c.(1759-1761)GAT>TAT	p.D587Y	NRXN1_uc002rxb.3_Missense_Mutation_p.D219Y|NRXN1_uc002rxe.3_Missense_Mutation_p.D547Y|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGGTGGCCATCTAGCATCTCA	0.438			NA											63	41					1.53716e-24	2.4209e-24	0.00361	1	0
NRXN1	9378	broad.mit.edu	37	2	50850543	50850543	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:50850543G>C	uc010fbq.2	-	6	2619	c.1142C>G	c.(1141-1143)TCA>TGA	p.S381*	NRXN1_uc002rxb.3_Nonsense_Mutation_p.S28*|NRXN1_uc002rxe.3_Nonsense_Mutation_p.S348*|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAGGCCCCTGATCCCAAATT	0.463			NA											5	106					0	0	0.000602	0	0
NRXN1	9378	broad.mit.edu	37	2	51254659	51254659	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:51254659G>T	uc010fbq.2	-	2	2230	c.753C>A	c.(751-753)CGC>CGA	p.R251R	NRXN1_uc002rxe.3_Silent_p.R251R|NRXN1_uc002rxd.1_Silent_p.R251R	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGTCCTTGCCGCGGAAGCCGG	0.746			NA											16	17					2.39187e-15	3.23488e-15	0.008871	1	0
PNPT1	87178	broad.mit.edu	37	2	55921012	55921012	+	Splice_Site	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:55921012A>T	uc002rzf.2	-	1	1	c.-52_splice	c.e1-1		PNPT1_uc002rzg.2_Splice_Site	NM_033109	NP_149100	Q8TCS8	PNPT1_HUMAN	polyribonucleotide nucleotidyltransferase 1						mRNA catabolic process|RNA processing	plasma membrane	3'-5'-exoribonuclease activity|polyribonucleotide nucleotidyltransferase activity|RNA binding				0			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			CACTCCGCAGACCGTGGGGCG	0.662			NA											10	7					0	0	0.006214	0	0
KIAA1841	84542	broad.mit.edu	37	2	61333783	61333783	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:61333783G>T	uc002saw.3	+	14	1900	c.1597G>T	c.(1597-1599)GGG>TGG	p.G533W	KIAA1841_uc002sax.3_Missense_Mutation_p.G387W|KIAA1841_uc002say.2_Missense_Mutation_p.G533W	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	533											0			Epithelial(17;0.193)			TCCCAAAACTGGGGAGCTCAA	0.358			NA											37	50					9.45814e-24	1.47517e-23	0.004878	1	0
ZNF638	27332	broad.mit.edu	37	2	71576910	71576910	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:71576910G>T	uc002shx.2	+	2	1145	c.826G>T	c.(826-828)GGT>TGT	p.G276C	ZNF638_uc010fec.2_Missense_Mutation_p.G382C|ZNF638_uc010yqw.1_Intron|ZNF638_uc002shw.2_Missense_Mutation_p.G276C|ZNF638_uc002shy.2_Missense_Mutation_p.G276C|ZNF638_uc002shz.2_Missense_Mutation_p.G276C|ZNF638_uc002sia.2_Missense_Mutation_p.G276C|ZNF638_uc002sib.1_Missense_Mutation_p.G276C	NM_014497	NP_055312	Q14966	ZN638_HUMAN	zinc finger protein 638	276					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			pancreas(2)|ovary(1)|skin(1)	4						GGACTTCCCCGGTGAGTCCTC	0.433			NA											44	67					9.39024e-22	1.42773e-21	0.009718	1	0
ALMS1	7840	broad.mit.edu	37	2	73826635	73826635	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:73826635G>T	uc002sje.1	+	19	11769	c.11658G>T	c.(11656-11658)AAG>AAT	p.K3886N	ALMS1_uc002sjf.1_Missense_Mutation_p.K3842N|ALMS1_uc002sjh.1_Missense_Mutation_p.K3272N	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	3884					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TGTTAAACAAGGGCATACAAG	0.254			NA											18	70					1.99824e-07	2.29081e-07	0.00499	1	0
C2orf78	388960	broad.mit.edu	37	2	74043870	74043870	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:74043870G>A	uc002sjr.1	+	3	2641	c.2520G>A	c.(2518-2520)AAG>AAA	p.K840K		NM_001080474	NP_001073943	A6NCI8	CB078_HUMAN	hypothetical protein LOC388960	840										ovary(2)	2						CACTGCCCAAGCCTCAAAATC	0.517			NA											33	44					0	0	0.003755	0	0
RTKN	6242	broad.mit.edu	37	2	74654377	74654377	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:74654377C>T	uc002sle.2	-	11	1396	c.1279G>A	c.(1279-1281)GAA>AAA	p.E427K	RTKN_uc002slc.2_Missense_Mutation_p.E414K|RTKN_uc002sld.2_Missense_Mutation_p.E377K	NM_001015055	NP_001015055	Q9BST9	RTKN_HUMAN	rhotekin isoform a	427					apoptosis|regulation of anti-apoptosis|Rho protein signal transduction	intracellular	GTP binding|GTP-Rho binding|GTPase inhibitor activity			skin(1)	1						TTCATGATTTCATCACAGCAC	0.493			NA											22	39					0	0	0.010504	0	0
DOK1	1796	broad.mit.edu	37	2	74784174	74784174	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:74784174G>T	uc002sms.2	+	5	1401	c.1379G>T	c.(1378-1380)AGC>ATC	p.S460I	DOK1_uc002smr.2_Missense_Mutation_p.S321I|DOK1_uc010ffo.2_Missense_Mutation_p.S321I|DOK1_uc002smt.2_Missense_Mutation_p.S246I|DOK1_uc002smu.2_Missense_Mutation_p.S246I|DOK1_uc010yrz.1_Missense_Mutation_p.S449I|DOK1_uc002smv.2_Missense_Mutation_p.S321I|DOK1_uc002smw.1_Missense_Mutation_p.S246I	NM_001381	NP_001372	Q99704	DOK1_HUMAN	docking protein 1	460					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	cytosol|perinuclear region of cytoplasm	insulin receptor binding				0						GCCTCAGGGAGCTGGGACTGT	0.602	Esophageal Squamous(36;520 860 12502 33616 51270)		NA											23	31					4.4004e-07	4.97101e-07	0.00333	1	0
LRRTM4	80059	broad.mit.edu	37	2	77746229	77746229	+	Missense_Mutation	SNP	G	G	T	rs144196554	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:77746229G>T	uc002snr.2	-	3	1181	c.766C>A	c.(766-768)CAC>AAC	p.H256N	LRRTM4_uc002snq.2_Missense_Mutation_p.H256N|LRRTM4_uc002sns.2_Missense_Mutation_p.H256N|LRRTM4_uc002snt.2_Missense_Mutation_p.H257N	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	256	LRR 9.|Extracellular (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TCCAAGTTGTGTAAGGAACTC	0.418			NA											6	14					5.9392e-07	6.68982e-07	0.001168	1	0
REG3G	130120	broad.mit.edu	37	2	79253911	79253911	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:79253911C>A	uc002snw.2	+	3	234	c.149C>A	c.(148-150)CCC>CAC	p.P50H	REG3G_uc002snx.2_Missense_Mutation_p.P50H|REG3G_uc010ffu.2_Missense_Mutation_p.P50H	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	50	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						TATGGCTCCCCCTGCTATGCC	0.527			NA											14	25					9.31168e-06	1.02091e-05	0.001855	1	0
REG1A	5967	broad.mit.edu	37	2	79348029	79348029	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:79348029G>T	uc002snz.2	+	2	145	c.42G>T	c.(40-42)CTG>CTT	p.L14L	REG1A_uc010ffx.1_Silent_p.L14L|REG1A_uc010ysd.1_Silent_p.L14L	NM_002909	NP_002900	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha precursor	14					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding				0						TCTCCTGCCTGATGTTTCTGT	0.458			NA											21	23					1.66031e-10	2.03616e-10	0.003954	1	0
REG3A	5068	broad.mit.edu	37	2	79384806	79384806	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:79384806C>T	uc002sod.1	-	4	607	c.352G>A	c.(352-354)GAA>AAA	p.E118K	REG3A_uc002soe.1_Missense_Mutation_p.E118K|REG3A_uc002sof.1_Missense_Mutation_p.E118K	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	118	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						TCCCAACCTTCTCCATTGGGC	0.552			NA											24	40					0	0	0.00278	0	0
CTNNA2	1496	broad.mit.edu	37	2	79971607	79971607	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:79971607A>T	uc010ysh.1	+	2	202	c.197A>T	c.(196-198)CAA>CTA	p.Q66L	CTNNA2_uc010yse.1_Missense_Mutation_p.Q66L|CTNNA2_uc010ysf.1_Missense_Mutation_p.Q66L|CTNNA2_uc010ysg.1_Missense_Mutation_p.Q66L	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	66					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						TCTGTAGAGCAAGCCACTCAG	0.458			NA											7	17					0	0	0.00308	0	0
GNLY	10578	broad.mit.edu	37	2	85923143	85923143	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:85923143C>G	uc002sql.3	+	3	347	c.219C>G	c.(217-219)GTC>GTG	p.V73V	GNLY_uc010fgp.2_Silent_p.V58V|GNLY_uc010ysx.1_Silent_p.V100V	NM_006433	NP_006424	P22749	GNLY_HUMAN	granulysin isoform NKG5	73	Saposin B-type.				cellular defense response|defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space					0						TGACGATAGTCCAAAAACTGA	0.552			NA											14	20					0	0	0.00245	0	0
ASTL	431705	broad.mit.edu	37	2	96798378	96798378	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:96798378C>A	uc010yui.1	-	6	538	c.538G>T	c.(538-540)GTC>TTC	p.V180F		NM_001002036	NP_001002036	Q6HA08	ASTL_HUMAN	astacin-like metalloendopeptidase precursor	180					proteolysis		metalloendopeptidase activity|zinc ion binding				0						TCATGAAGGACAATGCCCCGG	0.637			NA											49	72					9.55421e-19	1.37791e-18	0.00361	1	0
TMEM131	23505	broad.mit.edu	37	2	98392311	98392311	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:98392311T>G	uc002syh.3	-	32	4544	c.4315A>C	c.(4315-4317)AAG>CAG	p.K1439Q		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1439	Lys-rich.					integral to membrane				ovary(4)|central_nervous_system(2)	6						CGTACCTCCTTGAGGAGCGGT	0.512			NA											15	19					0	0	0.004007	0	0
C2orf55	343990	broad.mit.edu	37	2	99443583	99443583	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:99443583C>T	uc002szf.1	-	6	884	c.590G>A	c.(589-591)CGG>CAG	p.R197Q		NM_207362	NP_997245	Q6NV74	CB055_HUMAN	hypothetical protein LOC343990	197											0						GTCTGAGATCCGGGCAGAGAC	0.557			NA											19	48					0	0	0.002299	0	0
RNF149	284996	broad.mit.edu	37	2	101924612	101924613	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:101924612_101924613TG>AT	uc002taz.1	-	1	540_541	c.438_439CA>AT	c.(436-441)ATCACC>ATATCC	p.T147S	RNF149_uc002tax.1_RNA	NM_173647	NP_775918	Q8NC42	RN149_HUMAN	ring finger protein 149 precursor	147	PA.					integral to membrane	ligase activity|zinc ion binding			ovary(1)|breast(1)	2						ATGGGCAAGGTGATGTTCCCGT	0.683	Colon(25;331 612 6521 7355 31028)		NA											19	47					0	0	0.004672	0	0
IL18RAP	8807	broad.mit.edu	37	2	103068359	103068359	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:103068359A>G	uc002tbx.2	+	12	2002	c.1518A>G	c.(1516-1518)ACA>ACG	p.T506T	IL18RAP_uc010fiz.2_Silent_p.T364T	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	506	TIR.|Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						ATGATCAAACACTGAAACTCA	0.413			NA											13	72					0	0	0.001368	0	0
RGPD3	653489	broad.mit.edu	37	2	107040512	107040512	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:107040512T>A	uc010ywi.1	-	20	3968	c.3911A>T	c.(3910-3912)AAG>ATG	p.K1304M		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1304					intracellular transport		binding			ovary(1)	1						GGCAGGAGACTTAGATAGACT	0.403			NA											54	265					0	0	0.00361	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107446683	107446683	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:107446683G>T	uc002tdq.2	-	5	1276	c.1157C>A	c.(1156-1158)CCG>CAG	p.P386Q	ST6GAL2_uc002tdr.2_Missense_Mutation_p.P386Q|ST6GAL2_uc002tds.3_Missense_Mutation_p.P386Q	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	386	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GTTGTAATCCGGTTTTTTGTA	0.393			NA											10	42					1.08611e-07	1.2533e-07	0.000978	1	0
RGPD4	285190	broad.mit.edu	37	2	108487786	108487786	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:108487786G>C	uc010ywk.1	+	20	3408	c.3326G>C	c.(3325-3327)TGT>TCT	p.C1109S	RGPD4_uc002tdu.2_Missense_Mutation_p.C296S|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1109	RanBD1 1.				intracellular transport		binding			skin(2)	2						CTAAAAGTGTGTGCTAATCAT	0.443			NA											214	100					0	0	0.00361	0	0
SH3RF3	344558	broad.mit.edu	37	2	110053474	110053474	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:110053474G>T	uc010ywt.1	+	7	1700	c.1700G>T	c.(1699-1701)AGG>ATG	p.R567M		NM_001099289	NP_001092759	Q8TEJ3	SH3R3_HUMAN	SH3 domain containing ring finger 3	567							zinc ion binding			ovary(1)	1						ACTGCCACCAGGCCCGCCCTG	0.667			NA											22	64					7.41877e-09	8.79241e-09	0.001882	1	0
IL1F9	56300	broad.mit.edu	37	2	113742625	113742625	+	Nonstop_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:113742625G>T	uc002tio.1	+	5	578	c.509G>T	c.(508-510)TGA>TTA	p.*170L	IL1F9_uc010fkr.1_Nonstop_Mutation_p.*135L	NM_019618	NP_062564	Q9NZH8	IL36G_HUMAN	interleukin 1 family, member 9	170					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity				0						ATAAATGACTGAACTCAGCCT	0.294	Esophageal Squamous(44;715 981 6239 42838 46707)		NA											16	16					2.31682e-05	2.52152e-05	0.003163	1	0
GPR17	2840	broad.mit.edu	37	2	128408340	128408340	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:128408340C>A	uc010yzn.1	+	4	726	c.115C>A	c.(115-117)CTG>ATG	p.L39M	LIMS2_uc002tow.2_5'Flank|LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Missense_Mutation_p.L39M|GPR17_uc010yzo.1_Missense_Mutation_p.L11M|GPR17_uc002tpd.2_Missense_Mutation_p.L11M	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	39	Extracellular (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		tcccccaggtctgatcaccaa	0.104			NA									OREG0014966	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	95					2.81731e-10	3.442e-10	0.002096	1	0
HS6ST1	9394	broad.mit.edu	37	2	129025948	129025948	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:129025948C>A	uc002tpt.3	-	2	1058	c.1024G>T	c.(1024-1026)GAC>TAC	p.D342Y		NM_004807	NP_004798	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	342	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			pancreas(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		ATGTCCAGGTCGTTGAGCTCC	0.627			NA											20	55					1.56452e-12	1.99722e-12	0.007413	1	0
POTEE	445582	broad.mit.edu	37	2	131976074	131976074	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:131976074C>G	uc002tsn.2	+	1	151	c.99C>G	c.(97-99)CCC>CCG	p.P33P	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_5'UTR|POTEE_uc002tsl.2_5'UTR	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	33							ATP binding				0						GTTGCTTCCCCTGCTACAGGG	0.567			NA											193	129					0	0	0.00361	0	0
LYPD1	116372	broad.mit.edu	37	2	133426004	133426004	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:133426004C>A	uc002ttn.2	-	2	1135	c.159G>T	c.(157-159)ATG>ATT	p.M53I	LYPD1_uc002ttm.3_Missense_Mutation_p.M69I|LYPD1_uc002tto.2_Missense_Mutation_p.M1I	NM_144586	NP_653187	Q8N2G4	LYPD1_HUMAN	LY6/PLAUR domain containing 1 isoform a	53	UPAR/Ly6.					anchored to membrane|plasma membrane					0						CTTTCTGACACATGTCTTGAA	0.552			NA											18	54					5.35267e-07	6.03971e-07	0.007413	1	0
NCKAP5	344148	broad.mit.edu	37	2	133540099	133540099	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:133540099C>A	uc002ttp.2	-	14	4659	c.4285G>T	c.(4285-4287)GGG>TGG	p.G1429W	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1429							protein binding				0						TGAGTCCTCCCTGGGCTCTGC	0.577			NA											31	25					2.08457e-15	2.82124e-15	0.002096	1	0
NCKAP5	344148	broad.mit.edu	37	2	133543015	133543015	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:133543015G>T	uc002ttp.2	-	14	1743	c.1369C>A	c.(1369-1371)CTG>ATG	p.L457M	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	457							protein binding				0						GGGCTCCCCAGGTCAGCTGTT	0.473			NA											40	24					2.19358e-23	3.39391e-23	0.005524	1	0
R3HDM1	23518	broad.mit.edu	37	2	136467772	136467772	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:136467772G>T	uc002tuo.2	+	22	2972	c.2602G>T	c.(2602-2604)GAA>TAA	p.E868*	R3HDM1_uc010fni.2_Nonsense_Mutation_p.E867*|R3HDM1_uc002tup.2_Nonsense_Mutation_p.E813*|R3HDM1_uc010zbh.1_Nonsense_Mutation_p.E616*	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	868							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		GAAGTGTGTAGAATTTAGCAG	0.383			NA									OREG0014997	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	42					4.3838e-07	4.96386e-07	0.001855	1	0
LCT	3938	broad.mit.edu	37	2	136594312	136594312	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:136594312C>A	uc002tuu.1	-	1	439	c.428G>T	c.(427-429)AGA>ATA	p.R143I		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	143	Extracellular (Potential).|4 X approximate repeats.|1.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGCTTCGGTTCTCCGGAGGGT	0.602			NA											8	35					3.09899e-07	3.5297e-07	0.004482	1	0
THSD7B	80731	broad.mit.edu	37	2	137917812	137917812	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:137917812G>T	uc002tva.1	+	5	1306	c.1306G>T	c.(1306-1308)GTG>TTG	p.V436L	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Missense_Mutation_p.V326L	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		GGCATTATGTGTGGGACCCGC	0.498			NA											25	56					1.5548e-18	2.2307e-18	0.005443	1	0
LRP1B	53353	broad.mit.edu	37	2	141027836	141027836	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:141027836G>T	uc002tvj.1	-	86	14194	c.13222C>A	c.(13222-13224)CCC>ACC	p.P4408T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4408	Extracellular (Potential).|EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTGTCTCGGGGTCCAGCTGG	0.403	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			30	36					3.67414e-24	5.75834e-24	0.002445	1	0
LRP1B	53353	broad.mit.edu	37	2	141128289	141128289	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:141128289G>T	uc002tvj.1	-	71	11970	c.10998C>A	c.(10996-10998)AAC>AAA	p.N3666K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3666	Extracellular (Potential).|LDL-receptor class A 29.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTCTTTCACAGTTCTCTTCAT	0.413	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			45	107					1.81118e-26	2.91902e-26	0.00361	1	0
LRP1B	53353	broad.mit.edu	37	2	141473552	141473552	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:141473552G>T	uc002tvj.1	-	37	6985	c.6013C>A	c.(6013-6015)CCA>ACA	p.P2005T		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2005	Extracellular (Potential).|LDL-receptor class B 20.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTTTCTCTGGGTGCACAGCT	0.328	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			17	39					5.3912e-06	5.93431e-06	0.006122	1	0
LRP1B	53353	broad.mit.edu	37	2	141526841	141526841	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:141526841A>C	uc002tvj.1	-	35	6671	c.5699T>G	c.(5698-5700)ATG>AGG	p.M1900R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1900	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAAAGCATCCATTTTGTCACT	0.383	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			24	22					0	0	0.003954	0	0
KYNU	8942	broad.mit.edu	37	2	143715246	143715246	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:143715246A>T	uc002tvl.2	+	7	674	c.544A>T	c.(544-546)AAC>TAC	p.N182Y	KYNU_uc002tvk.2_Missense_Mutation_p.N182Y|KYNU_uc010fnm.2_Missense_Mutation_p.N182Y	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	182					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TCACGGACTTAACATTGAAGA	0.313			NA											8	22					0	0	0.004482	0	0
KYNU	8942	broad.mit.edu	37	2	143798057	143798057	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:143798057C>G	uc002tvl.2	+	13	1232	c.1102C>G	c.(1102-1104)CTG>GTG	p.L368V	KYNU_uc010fnm.2_Missense_Mutation_p.L368V	NM_003937	NP_003928	Q16719	KYNU_HUMAN	kynureninase (L-kynurenine hydrolase) isoform a	368					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			skin(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AACTGGCTATCTGGAATACCT	0.403			NA											28	22					0	0	0.007291	0	0
ZEB2	9839	broad.mit.edu	37	2	145157187	145157187	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:145157187T>A	uc002tvu.2	-	8	2047	c.1567A>T	c.(1567-1569)AAA>TAA	p.K523*	ZEB2_uc002tvv.2_Nonsense_Mutation_p.K517*|ZEB2_uc010zbm.1_Nonsense_Mutation_p.K494*|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Nonsense_Mutation_p.K552*	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	523						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		ATAATACTTTTAGTGGCACCA	0.423	Melanoma(33;1235 1264 5755 16332)		NA											19	57					0	0	0.006122	0	0
ZEB2	9839	broad.mit.edu	37	2	145274875	145274875	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:145274875G>T	uc002tvu.2	-	2	523	c.43C>A	c.(43-45)CGC>AGC	p.R15S	ZEB2_uc002tvv.2_Missense_Mutation_p.R10S|ZEB2_uc010zbm.1_Missense_Mutation_p.R10S|ZEB2_uc010fnp.2_Missense_Mutation_p.R10S|ZEB2_uc010fnq.1_Missense_Mutation_p.R44S|ZEB2_uc002tvw.2_Missense_Mutation_p.R10S|ZEB2_uc002tvx.1_RNA|ZEB2_uc002tvy.2_Missense_Mutation_p.R44S|ZEB2_uc002tvz.2_RNA|ZEB2_uc002twa.2_RNA	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	15						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		GCTTGTTTGCGCCTCTTGCAC	0.602	Melanoma(33;1235 1264 5755 16332)		NA											53	46					1.0442e-30	1.74695e-30	0.00361	1	0
MBD5	55777	broad.mit.edu	37	2	149247151	149247152	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:149247151_149247152CC>TT	uc002twm.3	+	12	4239_4240	c.3251_3252CC>TT	c.(3250-3252)TCC>TTT	p.S1084F	MBD5_uc010zbs.1_Intron|MBD5_uc010fns.2_Missense_Mutation_p.S1084F|MBD5_uc002two.2_Missense_Mutation_p.S342F|MBD5_uc002twp.2_Missense_Mutation_p.S134F	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1084						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GGTGATGCTTCCGTAGATGCCA	0.505			NA											43	80					0	0	0.004672	0	0
BAZ2B	29994	broad.mit.edu	37	2	160294873	160294873	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:160294873C>A	uc002uao.2	-	8	1586	c.1234G>T	c.(1234-1236)GGG>TGG	p.G412W	BAZ2B_uc002uap.2_Missense_Mutation_p.G410W|BAZ2B_uc002uas.1_Missense_Mutation_p.G349W|BAZ2B_uc002uau.1_Missense_Mutation_p.G410W|BAZ2B_uc002uaq.1_Missense_Mutation_p.G340W|BAZ2B_uc002uat.3_3'UTR|BAZ2B_uc010fop.1_Missense_Mutation_p.G410W	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						TTTTTATTCCCTGCTTTAAGA	0.338			NA											19	25					1.33834e-09	1.60767e-09	0.007413	1	0
CSRNP3	80034	broad.mit.edu	37	2	166451578	166451578	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:166451578G>T	uc002udf.2	+	4	379	c.3G>T	c.(1-3)ATG>ATT	p.M1I	CSRNP3_uc002udg.2_Missense_Mutation_p.M1I	NM_024969	NP_079245	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	1					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|large_intestine(1)|skin(1)	5						CTGCAGCGATGAGTGGAATTT	0.473			NA											14	26					1.05317e-09	1.26985e-09	0.00245	1	0
SCN1A	6323	broad.mit.edu	37	2	166894413	166894413	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:166894413G>T	uc010zcz.1	-	15	2804	c.2786C>A	c.(2785-2787)TCC>TAC	p.S929Y	SCN1A_uc002udo.3_Missense_Mutation_p.S809Y|SCN1A_uc010fpk.2_Missense_Mutation_p.S781Y	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	940	II.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	AATCAGGAAGGAGTGGAAGAA	0.507			NA											37	107					1.30998e-17	1.84928e-17	0.005524	1	0
XIRP2	129446	broad.mit.edu	37	2	168099742	168099742	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:168099742G>C	uc002udx.2	+	8	1858	c.1840G>C	c.(1840-1842)GTG>CTG	p.V614L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V439L|XIRP2_uc010fpq.2_Missense_Mutation_p.V392L|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	439	Xin 3.				actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TGGTGGTGATGTGAAATATAC	0.428			NA											17	35					0	0	0.006122	0	0
XIRP2	129446	broad.mit.edu	37	2	168101926	168101926	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:168101926G>T	uc002udx.2	+	8	4042	c.4024G>T	c.(4024-4026)GTA>TTA	p.V1342L	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V1167L|XIRP2_uc010fpq.2_Missense_Mutation_p.V1120L|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1167					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AAAAGAAGAGGTAATTCATGG	0.378			NA											7	17					5.18039e-06	5.70876e-06	0.00308	1	0
XIRP2	129446	broad.mit.edu	37	2	168102750	168102750	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:168102750G>T	uc002udx.2	+	8	4866	c.4848G>T	c.(4846-4848)AGG>AGT	p.R1616S	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R1441S|XIRP2_uc010fpq.2_Missense_Mutation_p.R1394S|XIRP2_uc010fpr.2_Intron|XIRP2_uc010fps.1_5'Flank	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	1441					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTTCCAAAAGGGACTGTACTG	0.338			NA											15	12					1.52009e-12	1.94564e-12	0.003163	1	0
XIRP2	129446	broad.mit.edu	37	2	168107960	168107960	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:168107960G>T	uc002udx.2	+	8	10076	c.10058G>T	c.(10057-10059)AGA>ATA	p.R3353I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.R3178I|XIRP2_uc010fpq.2_Missense_Mutation_p.R3131I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	3178					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TCAAATAGAAGAGTTTATGCA	0.358			NA											16	59					2.32078e-09	2.78437e-09	0.003163	1	0
C2orf77	129881	broad.mit.edu	37	2	170518868	170518868	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:170518868A>T	uc002ufe.2	-	5	835	c.741T>A	c.(739-741)AAT>AAA	p.N247K		NM_001085447	NP_001078916	Q0VFZ6	CB077_HUMAN	hypothetical protein LOC129881	247	Potential.										0						CATATAATGCATTCTGTCGCT	0.313			NA											34	55					0	0	0.002096	0	0
UBR3	130507	broad.mit.edu	37	2	170917604	170917604	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:170917604G>C	uc010zdi.1	+	34	4801	c.4801G>C	c.(4801-4803)GAA>CAA	p.E1601Q	UBR3_uc002ufr.3_RNA|UBR3_uc010fqa.2_Missense_Mutation_p.E422Q|UBR3_uc002uft.3_Missense_Mutation_p.E458Q|UBR3_uc010zdj.1_Missense_Mutation_p.E292Q|UBR3_uc002ufu.3_Missense_Mutation_p.E107Q	NM_172070	NP_742067	Q6ZT12	UBR3_HUMAN	E3 ubiquitin-protein ligase UBR3	1601					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding				0						ATGTGATGCAGAAAAGTCTTA	0.289			NA											9	21					0	0	0.004482	0	0
MYO3B	140469	broad.mit.edu	37	2	171225814	171225814	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:171225814G>T	uc002ufy.2	+	9	1041	c.898G>T	c.(898-900)GTT>TTT	p.V300F	MYO3B_uc002ufv.2_Missense_Mutation_p.V287F|MYO3B_uc010fqb.1_Missense_Mutation_p.V287F|MYO3B_uc002ufz.2_Missense_Mutation_p.V300F|MYO3B_uc002ufw.2_RNA|MYO3B_uc002ufx.2_RNA|MYO3B_uc002uga.2_Missense_Mutation_p.V287F|MYO3B_uc002ugb.2_RNA	NM_138995	NP_620482	Q8WXR4	MYO3B_HUMAN	myosin IIIB isoform 2	300					response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			lung(8)|ovary(6)|skin(4)|central_nervous_system(1)	19						ACATGGAAAAGTTCTGTTTCT	0.418			NA											20	23					5.03518e-11	6.25436e-11	0.007413	1	0
CHN1	1123	broad.mit.edu	37	2	175742768	175742768	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:175742768C>A	uc002uji.2	-	6	879	c.349G>T	c.(349-351)GTG>TTG	p.V117L	CHN1_uc010zeq.1_Missense_Mutation_p.V117L|CHN1_uc002ujj.2_Intron	NM_001822	NP_001813	P15882	CHIN_HUMAN	chimerin (chimaerin) 1 isoform a	117	SH2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.226)			CCATCAGTCACCAGATCGTGG	0.438			NA	T	TAF15	extraskeletal myxoid chondrosarcoma								21	54					7.41877e-09	8.79241e-09	0.001882	1	0
PDE11A	50940	broad.mit.edu	37	2	178705003	178705003	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:178705003T>A	uc002ulq.2	-	6	1793	c.1475A>T	c.(1474-1476)TAC>TTC	p.Y492F	PDE11A_uc002ulp.2_Missense_Mutation_p.Y48F|PDE11A_uc002ulr.2_Missense_Mutation_p.Y242F|PDE11A_uc002uls.1_Missense_Mutation_p.Y134F|PDE11A_uc002ult.1_Missense_Mutation_p.Y242F|PDE11A_uc002ulu.1_Missense_Mutation_p.Y134F	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	492	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			CGGATCCTGGTAGGCATCACT	0.463			NA							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				18	23					0	0	0.007413	0	0
TTN	7273	broad.mit.edu	37	2	179408974	179408974	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179408974G>T	uc010zfg.1	-	294	88502	c.88278C>A	c.(88276-88278)AGC>AGA	p.S29426R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.S23121R|TTN_uc010zfi.1_Missense_Mutation_p.S23054R|TTN_uc010zfj.1_Missense_Mutation_p.S22929R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30353							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGCTGTATTCGCTCATACCCT	0.413			NA											21	39					2.32416e-17	3.26903e-17	0.002299	1	0
TTN	7273	broad.mit.edu	37	2	179435287	179435287	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179435287C>A	uc010zfg.1	-	275	68092	c.67868G>T	c.(67867-67869)GGA>GTA	p.G22623V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G16318V|TTN_uc010zfi.1_Missense_Mutation_p.G16251V|TTN_uc010zfj.1_Missense_Mutation_p.G16126V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23550							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGATCTTTCTCCTGCAACATT	0.433			NA											8	15					0.00307968	0.00318168	0.00308	1	0
TTN	7273	broad.mit.edu	37	2	179441953	179441953	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179441953C>A	uc010zfg.1	-	273	61629	c.61405G>T	c.(61405-61407)GTC>TTC	p.V20469F	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V14164F|TTN_uc010zfi.1_Missense_Mutation_p.V14097F|TTN_uc010zfj.1_Missense_Mutation_p.V13972F|uc002umv.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21396							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACATCAAGGACTGTTACCTTC	0.463			NA											10	19					0.00621372	0.00637862	0.006214	1	0
TTN	7273	broad.mit.edu	37	2	179598577	179598577	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179598577A>G	uc010zfg.1	-	50	12031	c.11807T>C	c.(11806-11808)CTA>CCA	p.L3936P	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.L597P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	4863							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGTCCTCCTAGTGCAATCAA	0.418			NA											21	38					0	0	0.008871	0	0
TTN	7273	broad.mit.edu	37	2	179613054	179613054	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179613054A>G	uc002unb.2	-	46	14297	c.14073T>C	c.(14071-14073)AGT>AGC	p.S4691S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCAATACTACTTTTCTCCA	0.308			NA											17	29					0	0	0.004007	0	0
TTN	7273	broad.mit.edu	37	2	179614488	179614488	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179614488G>A	uc002unb.2	-	46	12863	c.12639C>T	c.(12637-12639)AGC>AGT	p.S4213S	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAATTGGTGGCTACAATTAA	0.348			NA											10	28					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179629317	179629317	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179629317A>G	uc010zfg.1	-	42	10149	c.9925T>C	c.(9925-9927)TAT>CAT	p.Y3309H	TTN_uc010zfh.1_Missense_Mutation_p.Y3263H|TTN_uc010zfi.1_Missense_Mutation_p.Y3263H|TTN_uc010zfj.1_Missense_Mutation_p.Y3263H|TTN_uc002umz.1_5'Flank|TTN_uc002unb.2_Missense_Mutation_p.Y3309H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	3309							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACAGGTATAGACTGCCGCA	0.463			NA											49	43					0	0	0.00361	0	0
TTN	7273	broad.mit.edu	37	2	179634420	179634420	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179634420G>C	uc010zfg.1	-	37	9112	c.8888C>G	c.(8887-8889)ACC>AGC	p.T2963S	TTN_uc010zfh.1_Missense_Mutation_p.T2917S|TTN_uc010zfi.1_Missense_Mutation_p.T2917S|TTN_uc010zfj.1_Missense_Mutation_p.T2917S|TTN_uc002unb.2_Missense_Mutation_p.T2963S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2963							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTGTCAGGGTGGCACTGAC	0.353			NA											34	33					0	0	0.003755	0	0
TTN	7273	broad.mit.edu	37	2	179634423	179634423	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179634423G>T	uc010zfg.1	-	37	9109	c.8885C>A	c.(8884-8886)GCC>GAC	p.A2962D	TTN_uc010zfh.1_Missense_Mutation_p.A2916D|TTN_uc010zfi.1_Missense_Mutation_p.A2916D|TTN_uc010zfj.1_Missense_Mutation_p.A2916D|TTN_uc002unb.2_Missense_Mutation_p.A2962D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2962							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTCAGGGTGGCACTGACTTG	0.348			NA											37	33					4.10981e-09	4.90036e-09	0.005524	1	0
TTN	7273	broad.mit.edu	37	2	179659128	179659128	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179659128G>T	uc010zfg.1	-	8	1620	c.1396C>A	c.(1396-1398)CAG>AAG	p.Q466K	TTN_uc010zfh.1_Missense_Mutation_p.Q466K|TTN_uc010zfi.1_Missense_Mutation_p.Q466K|TTN_uc010zfj.1_Missense_Mutation_p.Q466K|TTN_uc002unb.2_Missense_Mutation_p.Q466K|TTN_uc010frg.1_Missense_Mutation_p.Q140K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	466							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCACGTACCTGTTCTTGAGCA	0.562			NA											64	111					3.13296e-38	5.48339e-38	0.00361	1	0
TTN	7273	broad.mit.edu	37	2	179664219	179664219	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:179664219C>A	uc002und.2	-	6	1134	c.909G>T	c.(907-909)CCG>CCT	p.P303P	TTN_uc010zfg.1_Silent_p.P303P|TTN_uc010zfh.1_Silent_p.P303P|TTN_uc010zfi.1_Silent_p.P303P|TTN_uc010zfj.1_Silent_p.P303P|TTN_uc002unb.2_Silent_p.P303P			Q8WZ42	TITIN_HUMAN	Homo sapiens cDNA FLJ32040 fis, clone NTONG2000858, highly similar to H.sapiens mRNA for titin protein.	303							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTACCTGACCGGAGATGGGG	0.438			NA											27	27					1.12875e-08	1.33599e-08	0.00632	1	0
CWC22	57703	broad.mit.edu	37	2	180810056	180810056	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:180810056T>A	uc010frh.1	-	20	2827	c.2527A>T	c.(2527-2529)AGT>TGT	p.S843C	CWC22_uc002uno.2_Missense_Mutation_p.S365C|CWC22_uc002unp.2_Missense_Mutation_p.S843C	NM_020943	NP_065994	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog	843						catalytic step 2 spliceosome	protein binding|RNA binding				0						AAATTTTCACTGTCTTTAATT	0.343			NA											29	51					0	0	0.00632	0	0
NEUROD1	4760	broad.mit.edu	37	2	182543242	182543242	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:182543242C>G	uc002uof.2	-	2	582	c.346G>C	c.(346-348)GGA>CGA	p.G116R	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	116	Helix-loop-helix motif.				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GCGTTCAGTCCGTGCATGCGG	0.552			NA											17	32					0	0	0.007413	0	0
PDE1A	5136	broad.mit.edu	37	2	183129066	183129066	+	Silent	SNP	C	C	T	rs146558594		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:183129066C>T	uc002uos.2	-	3	261	c.177G>A	c.(175-177)GCG>GCA	p.A59A	PDE1A_uc010zfp.1_5'UTR|PDE1A_uc002uoq.1_Silent_p.A59A|PDE1A_uc010zfq.1_Silent_p.A59A|PDE1A_uc002uor.2_Silent_p.A43A|PDE1A_uc002uov.1_RNA	NM_001003683	NP_001003683	P54750	PDE1A_HUMAN	phosphodiesterase 1A isoform 2	59					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			skin(2)|ovary(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.061)			GCACAGATGCCGCATATTCAA	0.378			NA											15	24					0	0	0.007413	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802586	185802586	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:185802586C>A	uc002uph.2	+	4	3057	c.2463C>A	c.(2461-2463)CCC>CCA	p.P821P		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	821						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GATTCCACCCCGGATTTGAAA	0.388			NA											11	35					6.40141e-05	6.88944e-05	0.000978	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803269	185803269	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:185803269G>C	uc002uph.2	+	4	3740	c.3146G>C	c.(3145-3147)TGT>TCT	p.C1049S		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1049						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						AATGTACCATGTGAGGTCTAC	0.463			NA											24	45					0	0	0.00278	0	0
FAM171B	165215	broad.mit.edu	37	2	187604953	187604953	+	Splice_Site	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:187604953A>C	uc002ups.2	+	2	351	c.239_splice	c.e2-2	p.V80_splice	FAM171B_uc002upr.1_Splice_Site_p.V80_splice	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946							integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						TTTTCTCTCCAGTGTCTGTAT	0.368			NA											12	10					0	0	0.000978	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187702221	187702221	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:187702221A>T	uc002upu.1	-	5	595	c.555T>A	c.(553-555)AGT>AGA	p.S185R		NM_182521	NP_872327	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM domain containing 2	185	RING-type 1.				apoptosis		zinc ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TGTTTGATGTACTCTGATAAT	0.343			NA											16	21					0	0	0.003163	0	0
COL5A2	1290	broad.mit.edu	37	2	189899755	189899755	+	Missense_Mutation	SNP	C	C	G	rs139229616	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:189899755C>G	uc002uqk.2	-	53	4515	c.4240G>C	c.(4240-4242)GAT>CAT	p.D1414H	COL5A2_uc010frx.2_Missense_Mutation_p.D990H	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	1414	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TTAGCTTGATCGTCCATGTAT	0.383			NA											20	42					0	0	0.010504	0	0
COL5A2	1290	broad.mit.edu	37	2	189923591	189923591	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:189923591C>A	uc002uqk.2	-	32	2389	c.2114G>T	c.(2113-2115)GGC>GTC	p.G705V	COL5A2_uc010frx.2_Missense_Mutation_p.G281V	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein	705					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TCCTAACGGGCCAACTGCTCC	0.358			NA											8	20					0.00621372	0.00637862	0.006214	1	0
Unknown	0	broad.mit.edu	37	2	190788274	190788274	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:190788274T>C	uc002uro.2	+	1	356	c.213T>C	c.(211-213)GAT>GAC	p.D71D						SubName: Full=cDNA FLJ54127, highly similar to Heterogeneous nuclear ribonucleoproteins C;												NA						CAGGAGAGGATGGCAGAATGA	0.483			NA											26	52					0	0	0.003954	0	0
SDPR	8436	broad.mit.edu	37	2	192701327	192701327	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:192701327C>A	uc002utb.2	-	2	930	c.600G>T	c.(598-600)GTG>GTT	p.V200V		NM_004657	NP_004648	O95810	SDPR_HUMAN	serum deprivation response protein	200						caveola|cytosol	phosphatidylserine binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	AGGAGAGGTCCACGGTGTGCA	0.532			NA											21	37					1.01871e-10	1.2557e-10	0.008871	1	0
DNAH7	56171	broad.mit.edu	37	2	196681586	196681586	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:196681586T>A	uc002utj.3	-	51	9628	c.9527A>T	c.(9526-9528)AAG>ATG	p.K3176M		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3176	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGCCAAGGCCTTGGAGGAAGA	0.393			NA											18	27					0	0	0.007413	0	0
NDUFS1	4719	broad.mit.edu	37	2	206994966	206994966	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:206994966C>T	uc002vbe.2	-	15	1681	c.1554G>A	c.(1552-1554)AGG>AGA	p.R518R	NDUFS1_uc010ziq.1_Silent_p.R532R|NDUFS1_uc010zir.1_Silent_p.R482R|NDUFS1_uc010zis.1_Silent_p.R461R|NDUFS1_uc010zit.1_Silent_p.R407R|NDUFS1_uc010ziu.1_Silent_p.R402R	NM_005006	NP_004997	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1,	518					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			ovary(1)	1					NADH(DB00157)	GACTTGCAATCCTGCAAAGCA	0.388			NA											7	20					0	0	0.004482	0	0
MDH1B	130752	broad.mit.edu	37	2	207621757	207621757	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:207621757T>C	uc002vbs.2	-	4	333	c.278A>G	c.(277-279)TAT>TGT	p.Y93C	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Missense_Mutation_p.Y93C|MDH1B_uc010fuj.2_5'UTR|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	93					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		GGTGACATCATAATAAAGCTA	0.363	Pancreas(76;29 1355 28675 37177 51207)		NA											13	12					0	0	0.003163	0	0
CREB1	1385	broad.mit.edu	37	2	208461697	208461697	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:208461697G>A	uc002vcc.2	+	9	1192	c.941G>A	c.(940-942)AGA>AAA	p.R314K	CREB1_uc002vcd.2_Missense_Mutation_p.R300K|FAM119A_uc002vce.2_Intron	NM_134442	NP_604391	P16220	CREB1_HUMAN	cAMP responsive element binding protein 1	314	Leucine-zipper.	Required for binding TORCs.			activation of phospholipase C activity|axon guidance|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway		protein dimerization activity|transcription cofactor activity		EWSR1/CREB1(42)	soft_tissue(42)|breast(1)|central_nervous_system(1)	44				LUSC - Lung squamous cell carcinoma(261;0.0768)|Epithelial(149;0.127)|Lung(261;0.145)	Adenosine monophosphate(DB00131)|Bromocriptine(DB01200)|Naloxone(DB01183)	TTAGAAAACAGAGTGGCAGTG	0.358			NA	T	EWSR1	clear cell sarcoma|angiomatoid fibrous histiocytoma								16	25					0	0	0.007413	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208866251	208866252	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:208866251_208866252CC>AG	uc002vcl.2	-	2	602_603	c.112_113GG>CT	c.(112-114)GGG>CTG	p.G38L	PLEKHM3_uc002vcm.2_Missense_Mutation_p.G38L	NM_001080475	NP_001073944	Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M,	38					intracellular signal transduction		metal ion binding			ovary(1)	1						TTCCTGGATCCCATAAACCTCT	0.485			NA											49	70					0	0	0.004672	0	0
CRYGC	1420	broad.mit.edu	37	2	208994375	208994375	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:208994375G>T	uc002vco.3	-	2	80	c.42C>A	c.(40-42)GGC>GGA	p.G14G		NM_020989	NP_066269	P07315	CRGC_HUMAN	crystallin, gamma C	14	Beta/gamma crystallin 'Greek key' 1.				visual perception	cytoplasm|nucleus	protein binding|structural constituent of eye lens				0				LUSC - Lung squamous cell carcinoma(261;0.0703)|Epithelial(149;0.0858)|Lung(261;0.133)		CGTAGCTGCGGCCCTGGAAGG	0.517			NA											62	93					1.48873e-21	2.25113e-21	0.00361	1	0
UNC80	285175	broad.mit.edu	37	2	210640637	210640637	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:210640637A>G	uc010zjc.1	+	3	246	c.166A>G	c.(166-168)AAC>GAC	p.N56D	UNC80_uc002vdj.1_Missense_Mutation_p.N56D	NM_032504	NP_115893	Q8N2C7	UNC80_HUMAN	chromosome 2 open reading frame 21 isoform 1	56						integral to membrane					0						GTTGGTAGAAAACAAGCTGCA	0.388			NA											36	61					0	0	0.004289	0	0
CPS1	1373	broad.mit.edu	37	2	211465408	211465408	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:211465408A>C	uc002vee.3	+	15	1811	c.1679A>C	c.(1678-1680)AAG>ACG	p.K560T	CPS1_uc010fur.2_Missense_Mutation_p.K566T|CPS1_uc010fus.2_Missense_Mutation_p.K109T	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	560	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		ATCAATGAAAAGATTGCTCCA	0.393			NA											36	37					0	0	0.004289	0	0
SPAG16	79582	broad.mit.edu	37	2	214174813	214174813	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:214174813G>T	uc002veq.2	+	4	402	c.310G>T	c.(310-312)GCA>TCA	p.A104S	SPAG16_uc010fuz.1_Intron|SPAG16_uc002ver.2_Missense_Mutation_p.A50S|SPAG16_uc010zjk.1_Intron|SPAG16_uc002veo.2_Missense_Mutation_p.A104S|SPAG16_uc002vep.1_Intron|SPAG16_uc002ves.1_Missense_Mutation_p.A73S	NM_024532	NP_078808	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16 isoform 1	104					cilium assembly	cilium axoneme|flagellar axoneme				ovary(1)|skin(1)	2		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		TTCAAAGCATGCAGTACCTGA	0.323			NA											14	22					1.3612e-06	1.52348e-06	0.003163	1	0
FN1	2335	broad.mit.edu	37	2	216262534	216262534	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:216262534C>G	uc002vfa.2	-	22	3652	c.3386G>C	c.(3385-3387)CGA>CCA	p.R1129P	FN1_uc002vfb.2_Missense_Mutation_p.R1129P|FN1_uc002vfc.2_Missense_Mutation_p.R1129P|FN1_uc002vfd.2_Missense_Mutation_p.R1129P|FN1_uc002vfe.2_Missense_Mutation_p.R1129P|FN1_uc002vff.2_Missense_Mutation_p.R1129P|FN1_uc002vfg.2_Missense_Mutation_p.R1129P|FN1_uc002vfh.2_Missense_Mutation_p.R1129P|FN1_uc002vfi.2_Missense_Mutation_p.R1129P|FN1_uc002vfj.2_Missense_Mutation_p.R1129P	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	1129	|Fibronectin type-III 6.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTCACTTCTCGTGGTGCCTC	0.498			NA											23	39					0	0	0.007291	0	0
XRCC5	7520	broad.mit.edu	37	2	216995607	216995607	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:216995607A>G	uc002vfy.2	+	9	1087	c.947A>G	c.(946-948)TAT>TGT	p.Y316C	XRCC5_uc002vfz.2_Missense_Mutation_p.Y202C	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	316	Ku.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		GGGTTCCGCTATGGAAGTGAT	0.388			NA						Direct_reversal_of_damage|NHEJ					13	19					0	0	0.001368	0	0
MARCH4	57574	broad.mit.edu	37	2	217234468	217234468	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:217234468C>G	uc002vgb.2	-	1	2283	c.516G>C	c.(514-516)CAG>CAC	p.Q172H		NM_020814	NP_065865	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4	172	RING-CH-type.					Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		GGGGACTCACCTGTTCTGGCC	0.537			NA											31	40					0	0	0.004289	0	0
PRKAG3	53632	broad.mit.edu	37	2	219692580	219692580	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:219692580G>T	uc002vjb.1	-	7	815	c.796C>A	c.(796-798)CAA>AAA	p.Q266K	PRKAG3_uc010zkn.1_Intron|PRKAG3_uc010fvy.1_Missense_Mutation_p.N307K	NM_017431	NP_059127	Q9UGI9	AAKG3_HUMAN	AMP-activated protein kinase, non-catalytic	266					cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|intracellular protein kinase cascade|regulation of fatty acid oxidation	cytosol	AMP-activated protein kinase activity|protein kinase binding			ovary(1)|lung(1)	2		Renal(207;0.0474)		Epithelial(149;4.35e-07)|all cancers(144;8.96e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATCTTATGTTGTTCAATCTCA	0.572			NA											14	34					3.27435e-08	3.81942e-08	0.00245	1	0
CCDC108	255101	broad.mit.edu	37	2	219890813	219890813	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:219890813C>A	uc002vjl.1	-	14	2364	c.2280G>T	c.(2278-2280)CGG>CGT	p.R760R		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	760						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCCTCGTGCCCGCACCGTCA	0.592			NA											16	35					4.14922e-12	5.25513e-12	0.004007	1	0
GLB1L	79411	broad.mit.edu	37	2	220104998	220104998	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220104998G>T	uc002vkm.2	-	6	700	c.461C>A	c.(460-462)GCC>GAC	p.A154D	GLB1L_uc002vkk.2_5'UTR|GLB1L_uc010zkx.1_Intron|GLB1L_uc002vkn.2_Missense_Mutation_p.A154D	NM_024506	NP_078782	Q6UWU2	GLB1L_HUMAN	galactosidase, beta 1-like precursor	154					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds				0		all_lung(227;1.19e-05)|Lung NSC(271;2.76e-05)|Medulloblastoma(418;0.0208)|Esophageal squamous(248;0.0559)		Epithelial(149;1.3e-11)|all cancers(144;2.07e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTCCACTGCGGCAAGGAAGTC	0.463			NA											25	35					4.4004e-07	4.97101e-07	0.00333	1	0
PTPRN	5798	broad.mit.edu	37	2	220164462	220164462	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220164462C>T	uc002vkz.2	-	10	1572	c.1483G>A	c.(1483-1485)GAG>AAG	p.E495K	PTPRN_uc010zlc.1_Missense_Mutation_p.E405K|PTPRN_uc002vla.2_Intron	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	495	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TGCACATGCTCAGCCAGGATC	0.577			NA											6	68					0	0	0.001984	0	0
SPEG	10290	broad.mit.edu	37	2	220354191	220354191	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220354191C>G	uc010fwg.2	+	36	8451	c.8451C>G	c.(8449-8451)GTC>GTG	p.V2817V		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	2817	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CCCCGTCAGTCACTGTCAGCC	0.672			NA											4	60					0	0	0.009096	0	0
GMPPA	29926	broad.mit.edu	37	2	220369964	220369964	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220369964G>A	uc002vlr.2	+	8	703	c.635G>A	c.(634-636)GGC>GAC	p.G212D	GMPPA_uc002vls.2_Missense_Mutation_p.G212D|GMPPA_uc002vlt.2_Missense_Mutation_p.G212D|GMPPA_uc002vlu.2_Missense_Mutation_p.G212D|GMPPA_uc002vlv.2_Missense_Mutation_p.G212D|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.G212D	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	212					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		GACTCACCAGGCTTGTGGCCA	0.592			NA											15	32					0	0	0.00499	0	0
OBSL1	23363	broad.mit.edu	37	2	220435139	220435139	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220435139C>A	uc010fwk.2	-	1	873	c.816G>T	c.(814-816)AAG>AAT	p.K272N	OBSL1_uc010fwl.1_5'Flank|OBSL1_uc002vmi.2_Missense_Mutation_p.K272N|OBSL1_uc002vmj.2_Intron|INHA_uc002vmk.1_5'Flank	NM_015311	NP_056126	O75147	OBSL1_HUMAN	obscurin-like 1	272	Ig-like 3.				cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity				0		Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		CGGGCTCGGGCTTGCCCATCA	0.701			NA											16	36					1.37285e-15	1.86585e-15	0.004007	1	0
STK11IP	114790	broad.mit.edu	37	2	220476523	220476523	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220476523A>T	uc002vml.2	+	18	2378	c.2335A>T	c.(2335-2337)ACC>TCC	p.T779S		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	779					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCACCGAGCACCCGTGACCA	0.597			NA											9	18					0	0	0.004482	0	0
STK11IP	114790	broad.mit.edu	37	2	220479832	220479832	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:220479832C>T	uc002vml.2	+	24	2962	c.2919C>T	c.(2917-2919)CTC>CTT	p.L973L		NM_052902	NP_443134	Q8N1F8	S11IP_HUMAN	LKB1 interacting protein	973					protein localization	cytoplasm	protein kinase binding			ovary(1)	1		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCACCTGCCTCGTATCCCTGT	0.632			NA											5	14					0	0	0.000602	0	0
COL4A4	1286	broad.mit.edu	37	2	227915763	227915763	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:227915763C>T	uc010zlt.1	-	33	3734	c.3080G>A	c.(3079-3081)GGA>GAA	p.G1027E		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1027	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		GCCTGGGGGTCCAGGAGGCCC	0.587			NA											32	78					0	0	0.009535	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882198	228882198	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:228882198G>A	uc002vpq.2	-	7	3419	c.3372C>T	c.(3370-3372)AGC>AGT	p.S1124S	SPHKAP_uc002vpp.2_Silent_p.S1124S|SPHKAP_uc010zlx.1_Silent_p.S1124S	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1124						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATCGGTGATGCTCTCACAGC	0.547			NA											17	24					0	0	0.004007	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884135	228884135	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:228884135T>G	uc002vpq.2	-	7	1482	c.1435A>C	c.(1435-1437)ACC>CCC	p.T479P	SPHKAP_uc002vpp.2_Missense_Mutation_p.T479P|SPHKAP_uc010zlx.1_Missense_Mutation_p.T479P	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	479						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ATGCTTGAGGTTTCAACAGAG	0.532			NA											18	28					0	0	0.001882	0	0
TRIP12	9320	broad.mit.edu	37	2	230744732	230744732	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:230744732C>A	uc002vpw.1	-	2	173	c.64G>T	c.(64-66)GGG>TGG	p.G22W	TRIP12_uc002vpx.1_Missense_Mutation_p.G22W|TRIP12_uc002vpy.1_Missense_Mutation_p.G22W|TRIP12_uc010zlz.1_RNA|TRIP12_uc010fxh.1_Missense_Mutation_p.G22W	NM_004238	NP_004229	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	22					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			ovary(4)|lung(2)|breast(1)|central_nervous_system(1)|skin(1)	9		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GGTTGGGCCCCGGCAGTGTTC	0.448			NA											9	89					6.40141e-05	6.88944e-05	0.000978	1	0
DIS3L2	129563	broad.mit.edu	37	2	233201200	233201200	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:233201200G>C	uc010fxz.2	+	21	2794	c.2518G>C	c.(2518-2520)GTG>CTG	p.V840L	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA|DIS3L2_uc002vsp.1_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	840							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CTTCAGCCTGGTGGAGGTGGT	0.652			NA											16	14					0	0	0.003163	0	0
ALPP	250	broad.mit.edu	37	2	233245182	233245182	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:233245182C>G	uc002vsq.2	+	7	1010	c.845C>G	c.(844-846)CCG>CGG	p.P282R	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	282						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		TCCCTGGACCCGTCTGTGACC	0.637			NA											6	116					0	0	0.00308	0	0
TRPM8	79054	broad.mit.edu	37	2	234851361	234851361	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:234851361G>T	uc002vvh.2	+	6	708	c.668G>T	c.(667-669)CGG>CTG	p.R223L	TRPM8_uc010fyj.2_5'UTR|TRPM8_uc002vvi.3_Missense_Mutation_p.R173L|TRPM8_uc002vvj.3_Missense_Mutation_p.R146L	NM_024080	NP_076985	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel,	223	Cytoplasmic (Potential).					integral to membrane				skin(4)	4		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	GTCTCCAACCGGGACACCCTC	0.552			NA											39	79					9.73076e-26	1.55403e-25	0.006999	1	0
CXCR7	57007	broad.mit.edu	37	2	237489245	237489245	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:237489245C>A	uc010fyq.2	+	3	367	c.137C>A	c.(136-138)ACG>AAG	p.T46K	CXCR7_uc002vwd.2_Missense_Mutation_p.T46K	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	46	Helical; Name=1; (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		CTGCTCTACACGCTCTCCTTC	0.527			NA											17	10					3.45872e-05	3.74953e-05	0.004007	1	0
CXCR7	57007	broad.mit.edu	37	2	237489334	237489334	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:237489334G>A	uc010fyq.2	+	3	456	c.226G>A	c.(226-228)GGC>AGC	p.G76S	CXCR7_uc002vwd.2_Missense_Mutation_p.G76S	NM_020311	NP_064707	P25106	CXCR7_HUMAN	chemokine orphan receptor 1	76	Cytoplasmic (Potential).				interspecies interaction between organisms	integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3		Breast(86;0.000182)|Renal(207;0.00339)|all_hematologic(139;0.0048)|Acute lymphoblastic leukemia(138;0.0775)|Ovarian(221;0.089)|all_lung(227;0.147)|all_neural(83;0.223)		Epithelial(121;8.35e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.09e-11)|Kidney(56;1.11e-07)|KIRC - Kidney renal clear cell carcinoma(57;3.03e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000176)|Lung(119;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.118)		CAAGACCACAGGCTATGACAC	0.537			NA											15	25					0	0	0.003163	0	0
COL6A3	1293	broad.mit.edu	37	2	238262032	238262032	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:238262032A>T	uc002vwl.2	-	25	6927	c.6642T>A	c.(6640-6642)GGT>GGA	p.G2214G	COL6A3_uc002vwo.2_Silent_p.G2008G|COL6A3_uc010znj.1_Silent_p.G1607G|COL6A3_uc002vwp.1_Silent_p.G35G	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	2214	Triple-helical region.|Collagen-like 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GCTGGCCAGGACCGCCCTTGT	0.532			NA											14	20					0	0	0.004007	0	0
COL6A3	1293	broad.mit.edu	37	2	238283063	238283063	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:238283063G>T	uc002vwl.2	-	8	3956	c.3671C>A	c.(3670-3672)CCG>CAG	p.P1224Q	COL6A3_uc002vwo.2_Missense_Mutation_p.P1018Q|COL6A3_uc010znj.1_Missense_Mutation_p.P617Q|COL6A3_uc002vwq.2_Missense_Mutation_p.P1018Q|COL6A3_uc002vwr.2_Missense_Mutation_p.P817Q	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1224	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACCTGGGCTCGGTAGAGGCTG	0.582			NA											42	63					1.31131e-34	2.25628e-34	0.003214	1	0
COL6A3	1293	broad.mit.edu	37	2	238303671	238303671	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:238303671C>A	uc002vwl.2	-	3	553	c.268G>T	c.(268-270)GAG>TAG	p.E90*	COL6A3_uc002vwo.2_Intron|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Intron|COL6A3_uc002vwr.2_Intron|COL6A3_uc010znk.1_Nonsense_Mutation_p.E90*	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	90	VWFA 1.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AACAGGAACTCGGTATGTGGG	0.383			NA											31	27					3.1745e-13	4.09571e-13	0.008361	1	0
CAPN10	11132	broad.mit.edu	37	2	241537463	241537463	+	Silent	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:241537463A>C	uc002vzk.1	+	10	2086	c.1902A>C	c.(1900-1902)ACA>ACC	p.T634T	CAPN10_uc002vzl.1_Silent_p.T479T|CAPN10_uc002vzm.1_Silent_p.T100T|CAPN10_uc002vzn.1_Silent_p.T506T|CAPN10_uc002vzo.1_RNA|CAPN10_uc010fzg.1_RNA|CAPN10_uc002vzp.1_RNA|CAPN10_uc002vzq.1_Intron	NM_023083	NP_075571	Q9HC96	CAN10_HUMAN	calpain 10 isoform a	634	Domain III 2.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			ovary(3)|large_intestine(2)|lung(1)	6		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		TGCCGGACACAGAGGGGGCCT	0.657			NA											5	59					0	0	0.000602	0	0
KIF1A	547	broad.mit.edu	37	2	241724429	241724429	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:241724429C>A	uc002vzy.2	-	7	843	c.697G>T	c.(697-699)GAG>TAG	p.E233*	KIF1A_uc010fzk.2_Nonsense_Mutation_p.E233*|KIF1A_uc002vzz.1_Nonsense_Mutation_p.E233*	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	233	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ATATTGGTCTCTGCGTCATGG	0.607			NA											56	102					2.6711e-34	4.58377e-34	0.00361	1	0
NSFL1C	55968	broad.mit.edu	37	20	1426310	1426310	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:1426310C>A	uc002wfc.2	-	8	1898	c.950_splice	c.e8+1	p.R317_splice	NSFL1C_uc002wfd.2_Splice_Site_p.R206_splice|NSFL1C_uc002wfe.2_Splice_Site_p.R286_splice|NSFL1C_uc002wff.2_Splice_Site|NSFL1C_uc010gag.2_Splice_Site_p.R83_splice	NM_016143	NP_057227	Q9UNZ2	NSF1C_HUMAN	p47 protein isoform a							chromosome|Golgi stack|nucleus	lipid binding|protein binding				0						ATGCAAGGTACCTGTGGCTGT	0.512			NA											17	137					1.45105e-14	1.9182e-14	0.006122	1	0
SIRPA	140885	broad.mit.edu	37	20	1915365	1915365	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:1915365C>A	uc002wfq.2	+	8	1591	c.1231C>A	c.(1231-1233)CAT>AAT	p.H411N	SIRPA_uc010zps.1_Missense_Mutation_p.H391N|SIRPA_uc002wfr.2_Missense_Mutation_p.H411N|SIRPA_uc002wfs.2_Missense_Mutation_p.H411N|SIRPA_uc002wft.2_Missense_Mutation_p.H411N	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	411	Cytoplasmic (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		TTTTAGGTTGCATGAGCCCGA	0.323	GBM(155;1668 1920 5945 42733 48121)		NA											53	22					1.13709e-37	1.97763e-37	0.00361	1	0
TGM6	343641	broad.mit.edu	37	20	2411243	2411243	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:2411243C>A	uc002wfy.1	+	11	1891	c.1830C>A	c.(1828-1830)ATC>ATA	p.I610I	TGM6_uc010gal.1_Silent_p.I610I	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	610					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	TCATCACCATCAAGGTGACCT	0.547			NA											4	47					0.00024832	0.000262719	0.009096	1	0
ZNF343	79175	broad.mit.edu	37	20	2473448	2473448	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:2473448C>A	uc002wge.1	-	5	689	c.201G>T	c.(199-201)GTG>GTT	p.V67V	ZNF343_uc010gao.1_Silent_p.V67V|ZNF343_uc002wgd.1_5'UTR	NM_024325	NP_077301	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AGATCACAGTCACATCCCTGA	0.438			NA											91	42					1.11079e-38	1.94767e-38	0.00361	1	0
VPS16	64601	broad.mit.edu	37	20	2841496	2841496	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:2841496C>T	uc002whe.2	+	6	665	c.617C>T	c.(616-618)GCC>GTC	p.A206V	VPS16_uc002whh.2_5'Flank|VPS16_uc002whf.2_Missense_Mutation_p.A206V|VPS16_uc002whd.2_RNA|VPS16_uc002whg.2_5'Flank	NM_022575	NP_072097	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 isoform 1	206					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				ovary(2)|pancreas(1)|skin(1)	4						GACCATGCAGCCTGCTCCGCA	0.577			NA											41	23					0	0	0.00623	0	0
ProSAPiP1	9762	broad.mit.edu	37	20	3147616	3147616	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:3147616T>C	uc002wia.1	-	1	1592	c.194A>G	c.(193-195)CAG>CGG	p.Q65R	ProSAPiP1_uc002wib.1_Missense_Mutation_p.Q65R	NM_014731	NP_055546	O60299	PRIP1_HUMAN	ProSAPiP1 protein	65						cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				pancreas(1)	1						GAAACTGCCCTGGCTGCCCCC	0.706			NA											9	6					0	0	0.006214	0	0
ATRN	8455	broad.mit.edu	37	20	3559354	3559354	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:3559354A>T	uc002wim.2	+	15	2569	c.2479A>T	c.(2479-2481)ACA>TCA	p.T827S	ATRN_uc002wil.2_Missense_Mutation_p.T827S	NM_139321	NP_647537	O75882	ATRN_HUMAN	attractin isoform 1	827	Extracellular (Potential).|C-type lectin.				inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding			ovary(1)|breast(1)	2						GGCTTCTCTTACAACCCAGAA	0.383			NA											9	60					0	0	0.004482	0	0
ADAM33	80332	broad.mit.edu	37	20	3653478	3653478	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:3653478C>A	uc002wit.2	-	12	1288	c.1201G>T	c.(1201-1203)GGC>TGC	p.G401C	ADAM33_uc002wiq.1_5'Flank|ADAM33_uc002wir.1_Missense_Mutation_p.G401C|ADAM33_uc002wis.2_5'UTR|ADAM33_uc002wiu.2_Missense_Mutation_p.G401C|uc002wiv.1_5'Flank|ADAM33_uc002wiw.1_Intron|ADAM33_uc010gba.1_Intron|ADAM33_uc010gbb.1_Intron|ADAM33_uc002wix.1_Intron|ADAM33_uc010zqg.1_3'UTR|ADAM33_uc010zqh.1_3'UTR	NM_025220	NP_079496	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33 isoform alpha	401	Extracellular (Potential).|Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			large_intestine(2)|ovary(1)|skin(1)	4						CAAGCGCCGCCCCCCTTGCGG	0.731			NA											20	6					6.33239e-15	8.48119e-15	0.010504	1	0
MAVS	57506	broad.mit.edu	37	20	3842153	3842153	+	Splice_Site	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:3842153T>C	uc002wjw.3	+	4	634	c.465_splice	c.e4+2	p.E155_splice	MAVS_uc010zqn.1_Intron|MAVS_uc002wjx.3_Splice_Site_p.E14_splice|MAVS_uc002wjy.3_Intron	NM_020746	NP_065797	Q7Z434	MAVS_HUMAN	virus-induced signaling adapter						activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity				0						CCAGGAGAGGTCTGTCCTCAT	0.572			NA											32	20					0	0	0.002096	0	0
SLC23A2	9962	broad.mit.edu	37	20	4864461	4864461	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:4864461C>A	uc002wlg.1	-	9	1026	c.651G>T	c.(649-651)GGG>GGT	p.G217G	SLC23A2_uc010zqr.1_Intron|SLC23A2_uc002wlh.1_Silent_p.G217G|SLC23A2_uc002wli.2_Silent_p.G216G	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	217					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						TGATGATGGCCCCCTGGATCT	0.517			NA											27	15					2.44723e-14	3.22188e-14	0.004656	1	0
MCM8	84515	broad.mit.edu	37	20	5939246	5939246	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:5939246A>G	uc002wmi.2	+	7	1040	c.663A>G	c.(661-663)CTA>CTG	p.L221L	MCM8_uc002wmj.2_Silent_p.L221L|MCM8_uc002wmk.2_Silent_p.L221L|MCM8_uc002wml.2_Silent_p.L221L|MCM8_uc010gbp.2_Silent_p.L221L	NM_032485	NP_115874	Q9UJA3	MCM8_HUMAN	minichromosome maintenance complex component 8	221					cell cycle checkpoint|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|nucleoside-triphosphatase activity			skin(1)	1						ACATTGCTCTAAGAGGGACAG	0.408			NA											8	42					0	0	0.004482	0	0
PLCB1	23236	broad.mit.edu	37	20	8689329	8689329	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:8689329G>T	uc002wnb.2	+	12	1183	c.1180G>T	c.(1180-1182)GCA>TCA	p.A394S	PLCB1_uc010zrb.1_Missense_Mutation_p.A293S|PLCB1_uc002wna.2_Missense_Mutation_p.A394S|PLCB1_uc002wnc.1_Missense_Mutation_p.A293S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	394	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AGTGATAGAAGCAATTGCGGA	0.333			NA											17	8					5.03518e-11	6.25436e-11	0.007413	1	0
PLCB1	23236	broad.mit.edu	37	20	8717814	8717814	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:8717814A>T	uc002wnb.2	+	20	2186	c.2183A>T	c.(2182-2184)GAA>GTA	p.E728V	PLCB1_uc010zrb.1_Missense_Mutation_p.E627V|PLCB1_uc002wna.2_Missense_Mutation_p.E728V|PLCB1_uc002wnc.1_Missense_Mutation_p.E627V|PLCB1_uc002wnd.1_Missense_Mutation_p.E305V	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	728	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCTGTCTGGGAAGAAGAACCT	0.378			NA											15	42					0	0	0.003163	0	0
PLCB1	23236	broad.mit.edu	37	20	8770180	8770180	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:8770180G>T	uc002wnb.2	+	30	3297	c.3294G>T	c.(3292-3294)ATG>ATT	p.M1098I	PLCB1_uc002wna.2_Missense_Mutation_p.M1098I	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1098					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AGACAGAGATGATCCGGTCAT	0.398			NA											70	26					7.33394e-39	1.2871e-38	0.00361	1	0
PLCB4	5332	broad.mit.edu	37	20	9402015	9402015	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:9402015C>A	uc002wnf.2	+	25	2326	c.2190C>A	c.(2188-2190)CCC>CCA	p.P730P	PLCB4_uc010gbw.1_Silent_p.P730P|PLCB4_uc010gbx.2_Silent_p.P742P|PLCB4_uc002wne.2_Silent_p.P730P|PLCB4_uc002wnh.2_Silent_p.P577P	NM_182797	NP_877949	Q15147	PLCB4_HUMAN	phospholipase C beta 4 isoform b	730	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			skin(11)|ovary(3)|pancreas(1)	15						ATGGGTTGCCCACTGACACCA	0.418			NA											12	56					0.000978159	0.00102147	0.000978	1	0
PAK7	57144	broad.mit.edu	37	20	9546915	9546915	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:9546915G>T	uc002wnl.2	-	6	1652	c.1107C>A	c.(1105-1107)AGC>AGA	p.S369R	PAK7_uc002wnk.2_Missense_Mutation_p.S369R|PAK7_uc002wnj.2_Missense_Mutation_p.S369R|PAK7_uc010gby.1_Missense_Mutation_p.S369R	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	369	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			ACTGGTGACTGCTTGAGGAAT	0.567			NA											92	59					1.05875e-55	1.9464e-55	0.00361	1	0
FLRT3	23767	broad.mit.edu	37	20	14307564	14307564	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:14307564C>A	uc002wov.1	-	3	1056	c.589G>T	c.(589-591)GGT>TGT	p.G197C	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.G197C	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	197	Extracellular (Potential).|LRR 6.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CTAGTGAGACCTTGAAGAGAT	0.408			NA											59	24					7.47603e-22	1.13937e-21	0.00361	1	0
KIF16B	55614	broad.mit.edu	37	20	16407825	16407825	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:16407825C>G	uc002wpg.1	-	15	1694	c.1536G>C	c.(1534-1536)GTG>GTC	p.V512V	KIF16B_uc010gch.1_Silent_p.V512V|KIF16B_uc010gci.1_Silent_p.V512V|KIF16B_uc010gcj.1_Silent_p.V512V	NM_024704	NP_078980	Q96L93	KI16B_HUMAN	kinesin-like motor protein C20orf23	512	FHA.				cell communication|early endosome to late endosome transport|endoderm development|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|formation of primary germ layer|Golgi to endosome transport|microtubule-based movement|receptor catabolic process|regulation of receptor recycling	early endosome membrane|microtubule	ATP binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|plus-end-directed microtubule motor activity			skin(2)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|ovary(1)|kidney(1)	8						GTATCAGAGTCACTGTCCCCC	0.443			NA											70	27					0	0	0.00361	0	0
C20orf26	26074	broad.mit.edu	37	20	20051508	20051508	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:20051508A>T	uc002wru.2	+	3	230	c.154A>T	c.(154-156)AAC>TAC	p.N52Y	C20orf26_uc010gcw.1_Missense_Mutation_p.N6Y|C20orf26_uc010zse.1_Missense_Mutation_p.N52Y|C20orf26_uc010zsf.1_Missense_Mutation_p.N52Y	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	52										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		AGAAAAGGCCAACCTTGCTGT	0.473			NA											8	30					0	0	0.004482	0	0
INSM1	3642	broad.mit.edu	37	20	20350430	20350430	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:20350430C>G	uc002wrx.2	+	1	1666	c.1519C>G	c.(1519-1521)CGC>GGC	p.R507G		NM_002196	NP_002187	Q01101	INSM1_HUMAN	insulinoma-associated 1	507					endocrine pancreas development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0649)		GGTGCCCGTGCGCCCGGCCTG	0.667			NA											4	26					0	0	0.000602	0	0
FOXA2	3170	broad.mit.edu	37	20	22563685	22563685	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:22563685G>C	uc002wsn.2	-	3	367	c.177C>G	c.(175-177)AGC>AGG	p.S59R	FOXA2_uc002wsm.2_Missense_Mutation_p.S65R	NM_153675	NP_710141	Q9Y261	FOXA2_HUMAN	forkhead box A2 isoform 2	59	Transactivation domain 1 (By similarity).				cell differentiation in hindbrain|central nervous system myelin formation|chromatin modification|dorsal/ventral neural tube patterning|ectoderm formation|endocrine pancreas development|endoderm development|epithelial tube branching involved in lung morphogenesis|in utero embryonic development|lung epithelial cell differentiation|negative regulation of neuron differentiation|neuron fate specification|oligodendrocyte cell fate commitment|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of neuron differentiation|primitive streak formation|regulation of blood coagulation|regulation of sequence-specific DNA binding transcription factor activity|response to interleukin-6	cytoplasm|transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|kidney(1)|central_nervous_system(1)	4	Lung NSC(19;0.188)					TGGAGCCCGCGCTCATGTTGC	0.692			NA											60	35					0	0	0.00361	0	0
SSTR4	6754	broad.mit.edu	37	20	23016580	23016580	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:23016580G>A	uc002wsr.2	+	1	524	c.460G>A	c.(460-462)GCG>ACG	p.A154T		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	154	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCCTCTGCGCGCGGCGACCTA	0.662	Esophageal Squamous(15;850 1104 16640)		NA											9	65					0	0	0.004482	0	0
SSTR4	6754	broad.mit.edu	37	20	23017029	23017029	+	Missense_Mutation	SNP	C	C	G	rs4988475		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:23017029C>G	uc002wsr.2	+	1	973	c.909C>G	c.(907-909)AAC>AAG	p.N303K		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	303	Helical; Name=7; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GCTATGCCAACAGCTGCGCCA	0.577	Esophageal Squamous(15;850 1104 16640)		NA											104	55					0	0	0.00361	0	0
NXT1	29107	broad.mit.edu	37	20	23334706	23334706	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:23334706G>A	uc002wsx.1	+	2	415	c.28G>A	c.(28-30)GTG>ATG	p.V10M		NM_013248	NP_037380	Q9UKK6	NXT1_HUMAN	NTF2-like export factor 1	10						cytoplasm|nuclear pore				ovary(1)	1	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					CAAGACCTATGTGGATCAGGC	0.557			NA											14	88					0	0	0.00245	0	0
CST5	1473	broad.mit.edu	37	20	23856830	23856830	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:23856830C>G	uc002wtr.1	-	3	491	c.424G>C	c.(424-426)GTC>CTC	p.V142L		NM_001900	NP_001891	P28325	CYTD_HUMAN	cystatin D precursor	142						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding				0						GACCCCTAGACTTTCCGGCAC	0.542			NA											27	79					0	0	0.008361	0	0
ZNF341	84905	broad.mit.edu	37	20	32357894	32357894	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:32357894A>T	uc002wzy.2	+	10	1438	c.1418A>T	c.(1417-1419)TAC>TTC	p.Y473F	ZNF341_uc002wzx.2_Missense_Mutation_p.Y466F|ZNF341_uc010geq.2_Missense_Mutation_p.Y383F|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	473	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CTCAAGGTGTACAAGTGTGTG	0.577			NA											21	2					0	0	0.010504	0	0
DLGAP4	22839	broad.mit.edu	37	20	35127691	35127691	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:35127691C>T	uc002xff.2	+	9	2492	c.2057C>T	c.(2056-2058)CCC>CTC	p.P686L	DLGAP4_uc010zvp.1_Missense_Mutation_p.P686L|DLGAP4_uc002xfg.2_Intron|DLGAP4_uc002xfh.2_Intron|DLGAP4_uc002xfi.2_5'UTR|DLGAP4_uc002xfj.2_5'UTR	NM_014902	NP_055717	Q9Y2H0	DLGP4_HUMAN	disks large-associated protein 4 isoform a	684					cell-cell signaling	membrane	protein binding			skin(2)|ovary(1)	3	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				GACAACGGACCCAAAGCGATC	0.433			NA											27	7					0	0	0.002445	0	0
RALGAPB	57148	broad.mit.edu	37	20	37150226	37150226	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:37150226G>C	uc002xiw.2	+	10	1761	c.1504G>C	c.(1504-1506)GCA>CCA	p.A502P	RALGAPB_uc010zvz.1_Intron|RALGAPB_uc002xix.2_Missense_Mutation_p.A502P|RALGAPB_uc002xiy.1_Missense_Mutation_p.A502P|RALGAPB_uc002xiz.2_Missense_Mutation_p.A280P|RALGAPB_uc002xja.1_Missense_Mutation_p.A229P	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	502					activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TATGTTTGATGCAAGTGAATT	0.448			NA											81	9					0	0	0.00361	0	0
CHD6	84181	broad.mit.edu	37	20	40049492	40049492	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:40049492C>A	uc002xka.1	-	31	5961	c.5783G>T	c.(5782-5784)AGG>ATG	p.R1928M		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1928					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				GGGGAAAGCCCTCTGTAGCCC	0.507			NA											114	9					2.13259e-42	3.80131e-42	0.00361	1	0
PTPRT	11122	broad.mit.edu	37	20	40979280	40979280	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:40979280C>T	uc002xkg.2	-	11	2037	c.1853G>A	c.(1852-1854)GGA>GAA	p.G618E	PTPRT_uc010ggj.2_Missense_Mutation_p.G618E	NM_007050	NP_008981	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	618	Extracellular (Potential).|Fibronectin type-III 4.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			skin(8)|ovary(7)|lung(5)	20		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GACAGGAGCTCCCCGGGACTG	0.537			NA											72	16					0	0	0.00361	0	0
CSE1L	1434	broad.mit.edu	37	20	47675016	47675016	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:47675016G>T	uc002xty.2	+	2	150	c.16G>T	c.(16-18)GCA>TCA	p.A6S	CSE1L_uc010zyg.1_5'UTR|CSE1L_uc010ghx.2_Missense_Mutation_p.A6S	NM_001316	NP_001307	P55060	XPO2_HUMAN	CSE1 chromosome segregation 1-like protein	6					apoptosis|cell proliferation|intracellular protein transport	cytoplasm|nucleus	importin-alpha export receptor activity			large_intestine(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000491)|Colorectal(8;0.198)			ACTCAGCGATGCAAATCTGCA	0.333			NA											56	11					4.48484e-38	7.82823e-38	0.00361	1	0
KCNB1	3745	broad.mit.edu	37	20	47990813	47990813	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:47990813T>A	uc002xur.1	-	2	1448	c.1284A>T	c.(1282-1284)AAA>AAT	p.K428N	KCNB1_uc002xus.1_Missense_Mutation_p.K428N	NM_004975	NP_004966	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related	428	Cytoplasmic (Potential).				energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			pancreas(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GTTTGATTGCTTTCTCCTGTC	0.498			NA											118	19					0	0	0.00361	0	0
SALL4	57167	broad.mit.edu	37	20	50406859	50406859	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:50406859C>G	uc002xwh.3	-	2	2264	c.2163G>C	c.(2161-2163)ACG>ACC	p.T721T	SALL4_uc010gii.2_Intron|SALL4_uc002xwi.3_Intron	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	721					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CAAACCCTAGCGTGGGTGATG	0.597			NA											41	3					0	0	0.007835	0	0
RAE1	8480	broad.mit.edu	37	20	55929848	55929849	+	Missense_Mutation	DNP	TA	TA	AT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TA	TA	-	-	TA	TA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:55929848_55929849TA>AT	uc002xyg.2	+	3	512_513	c.171_172TA>AT	c.(169-174)CTTATT>CTATTT	p.I58F	RAE1_uc010gis.1_Missense_Mutation_p.L19Y|RAE1_uc010git.1_Missense_Mutation_p.I58F|RAE1_uc002xyh.2_Missense_Mutation_p.I58F|RAE1_uc002xyi.2_Missense_Mutation_p.I58F	NM_003610	NP_003601	P78406	RAE1L_HUMAN	RAE1 (RNA export 1, S.pombe) homolog	58					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|cytoskeleton|nuclear outer membrane|nuclear pore	microtubule binding|RNA binding				0	Lung NSC(12;0.00263)|all_lung(29;0.00828)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;3.7e-14)|Epithelial(14;1.07e-09)|all cancers(14;1.11e-08)			GGAACTTTCTTATTGCAGGATC	0.421			NA											19	64					0	0	0.004672	0	0
ZBP1	81030	broad.mit.edu	37	20	56188232	56188232	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:56188232G>A	uc002xyo.2	-	5	938	c.657C>T	c.(655-657)GTC>GTT	p.V219V	ZBP1_uc010gjm.2_Silent_p.V218V|ZBP1_uc002xyp.2_Silent_p.V144V|ZBP1_uc010zzn.1_Silent_p.V219V	NM_030776	NP_110403	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1 isoform a	219	RIP homotypic interaction motif (RHIM) 1.					cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			ovary(2)	2	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			CCTCCCTGGAGACTGTCTGTC	0.572			NA											47	7					0	0	0.002852	0	0
ZNF831	128611	broad.mit.edu	37	20	57768318	57768318	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:57768318G>T	uc002yan.2	+	1	2244	c.2244G>T	c.(2242-2244)CTG>CTT	p.L748L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	748						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGAGCCCCCTGGTCTCTCCAA	0.642			NA											16	1					2.23348e-06	2.47965e-06	0.004007	1	0
ZNF831	128611	broad.mit.edu	37	20	57828094	57828094	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:57828094G>A	uc002yan.2	+	4	4089	c.4089G>A	c.(4087-4089)AAG>AAA	p.K1363K		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1363						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GTTGTGGGAAGGAAGAGAAGA	0.468			NA											76	11					0	0	0.00361	0	0
CDH4	1002	broad.mit.edu	37	20	60509225	60509225	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:60509225C>A	uc002ybn.1	+	15	2505	c.2491C>A	c.(2491-2493)CCG>ACG	p.P831T	CDH4_uc002ybp.1_Missense_Mutation_p.P757T	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	831	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GCCCCAGTACCCGATCAGGCC	0.677			NA											47	6					3.39706e-21	5.12873e-21	0.00361	1	0
YTHDF1	54915	broad.mit.edu	37	20	61833654	61833654	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:61833654C>A	uc002yeh.2	-	4	1932	c.1638G>T	c.(1636-1638)GAG>GAT	p.E546D	YTHDF1_uc011aaq.1_Missense_Mutation_p.E496D	NM_017798	NP_060268	Q9BYJ9	YTHD1_HUMAN	YTH domain family, member 1	546										ovary(2)	2						GCACCACCTCCTCCTCCTCCT	0.542			NA											62	98					2.32582e-20	3.45213e-20	0.00361	1	0
COL20A1	57642	broad.mit.edu	37	20	61937381	61937381	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:61937381G>C	uc011aau.1	+	5	586	c.486G>C	c.(484-486)CCG>CCC	p.P162P	COL20A1_uc011aav.1_5'UTR	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	162					cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GCCAGGATCCGCGCACTCCTG	0.627			NA											13	62					0	0	0.001855	0	0
COL20A1	57642	broad.mit.edu	37	20	61941839	61941839	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:61941839G>C	uc011aau.1	+	11	1470	c.1370G>C	c.(1369-1371)GGC>GCC	p.G457A	COL20A1_uc011aav.1_Missense_Mutation_p.G278A	NM_020882	NP_065933	Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	457	Fibronectin type-III 2.				cell adhesion	collagen|extracellular space	structural molecule activity			central_nervous_system(1)	1	all_cancers(38;1.39e-10)					GTTGGCGAAGGCCTGCGGGGC	0.687			NA											8	17					0	0	0.00308	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981848	61981848	+	Silent	SNP	G	G	T	rs121912258		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:61981848G>T	uc002yes.2	-	5	1093	c.915C>A	c.(913-915)CTC>CTA	p.L305L	CHRNA4_uc002yet.1_Silent_p.L129L|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_Silent_p.L234L|CHRNA4_uc002yev.1_Silent_p.L129L|CHRNA4_uc010gkf.1_Silent_p.L129L	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	305					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	ACTCGCCGATGAGTGGGATGA	0.592			NA											46	93					8.00217e-19	1.1558e-18	0.00361	1	0
KCNQ2	3785	broad.mit.edu	37	20	62038193	62038193	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:62038193G>T	uc002yey.1	-	17	2600	c.2423C>A	c.(2422-2424)TCC>TAC	p.S808Y	KCNQ2_uc002yez.1_Missense_Mutation_p.S777Y|KCNQ2_uc002yfa.1_Missense_Mutation_p.S790Y|KCNQ2_uc002yfb.1_Missense_Mutation_p.S780Y	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	808	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	CTTGGACTGGGAGATGCTGAA	0.637			NA											17	26					3.41278e-10	4.16424e-10	0.00499	1	0
SRMS	6725	broad.mit.edu	37	20	62172823	62172823	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:62172823A>G	uc002yfi.1	-	6	1138	c.1097T>C	c.(1096-1098)GTG>GCG	p.V366A		NM_080823	NP_543013	Q9H3Y6	SRMS_HUMAN	src-related kinase lacking C-terminal regulatory	366	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity			stomach(1)|lung(1)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GAAGTCAGCCACCTTGCAGGC	0.706			NA											18	27					0	0	0.006122	0	0
PRIC285	85441	broad.mit.edu	37	20	62193511	62193511	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:62193511C>A	uc002yfm.2	-	11	7335	c.6443G>T	c.(6442-6444)GGA>GTA	p.G2148V	PRIC285_uc002yfl.1_Missense_Mutation_p.G1579V	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2148					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			GTGGCGGCCTCCGGGGATGTT	0.662			NA											19	33					5.35267e-07	6.03971e-07	0.007413	1	0
RTEL1	51750	broad.mit.edu	37	20	62292793	62292793	+	Missense_Mutation	SNP	C	C	T	rs143461704	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:62292793C>T	uc002yfu.1	+	3	588	c.245C>T	c.(244-246)CCG>CTG	p.P82L	RTEL1_uc011abc.1_RNA|RTEL1_uc002yft.1_Missense_Mutation_p.P82L|RTEL1_uc011abd.1_Missense_Mutation_p.P82L|RTEL1_uc002yfv.2_Missense_Mutation_p.P82L|RTEL1_uc011abe.1_5'UTR|RTEL1_uc002yfw.2_RNA	NM_016434	NP_057518	Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	82	Helicase ATP-binding.				DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding				0	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GAGCTTTTCCCGGATCGGGCC	0.647			NA											17	49					0	0	0.006122	0	0
MYT1	4661	broad.mit.edu	37	20	62839650	62839650	+	Silent	SNP	G	G	A	rs148738850		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:62839650G>A	uc002yii.2	+	7	1465	c.1101G>A	c.(1099-1101)TCG>TCA	p.S367S	MYT1_uc002yih.2_Intron|MYT1_uc002yij.2_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	367					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CTGACGAGTCGGAGATGCAGG	0.612	GBM(59;481 1041 20555 21139 33705)		NA											47	89					0	0	0.00361	0	0
MYT1	4661	broad.mit.edu	37	20	62848565	62848565	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:62848565C>T	uc002yii.2	+	11	2141	c.1777C>T	c.(1777-1779)CAG>TAG	p.Q593*	MYT1_uc002yih.2_Nonsense_Mutation_p.Q295*|MYT1_uc002yij.2_Nonsense_Mutation_p.Q225*	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	593					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TTTCGATGCTCAGGTTTTTGG	0.522	GBM(59;481 1041 20555 21139 33705)		NA											58	99					0	0	0.00361	0	0
TPTE	7179	broad.mit.edu	37	21	10944758	10944758	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:10944758T>A	uc002yip.1	-	11	844	c.476A>T	c.(475-477)AAC>ATC	p.N159I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N141I|TPTE_uc002yir.1_Missense_Mutation_p.N121I|TPTE_uc010gkv.1_Missense_Mutation_p.N21I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	159					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATCTAAAATGTTAAATAAGTC	0.318			NA											18	36					0	0	0.00499	0	0
BAGE2	85319	broad.mit.edu	37	21	11021212	11021212	+	Splice_Site	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:11021212C>G	uc002yit.1	-	9	1714	c.1506_splice	c.e9-1		TPTE_uc002yis.1_Splice_Site	NM_182482	NP_872288			B melanoma antigen family, member 2 precursor												0			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAGTAGACACCTATAAAAAGC	0.299			NA											7	54					0	0	0.004482	0	0
USP25	29761	broad.mit.edu	37	21	17150265	17150265	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:17150265G>A	uc002yjy.1	+	4	528	c.311G>A	c.(310-312)AGA>AAA	p.R104K	USP25_uc011aby.1_Missense_Mutation_p.R104K|USP25_uc002yjz.1_Missense_Mutation_p.R104K|USP25_uc010gla.1_Missense_Mutation_p.R104K	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	104	UIM 1.				protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		GATCTTCAGAGAGCAATTGCC	0.348			NA											23	4					0	0	0.009535	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28214257	28214257	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:28214257G>T	uc002ymf.2	-	3	1585	c.1130C>A	c.(1129-1131)ACT>AAT	p.T377N		NM_006988	NP_008919	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1	377	Peptidase M12B.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			lung(3)|large_intestine(2)|central_nervous_system(1)	6		Breast(209;0.000962)		Lung(58;0.215)		ATCACACACAGTTCCAACATC	0.453			NA											43	6					5.44703e-19	7.88514e-19	0.009718	1	0
ADAMTS5	11096	broad.mit.edu	37	21	28305285	28305285	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:28305285C>A	uc002ymg.2	-	5	2497	c.1768G>T	c.(1768-1770)GCC>TCC	p.A590S		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	590	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						TGACGATAGGCAAACTGCACT	0.542	Esophageal Squamous(53;683 1080 10100 14424 45938)		NA											23	1					1.96895e-08	2.31065e-08	0.00278	1	0
C21orf7	56911	broad.mit.edu	37	21	30547109	30547109	+	Missense_Mutation	SNP	G	G	C	rs149210929		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:30547109G>C	uc002yne.2	+	8	896	c.625G>C	c.(625-627)GCT>CCT	p.A209P	C21orf7_uc011acr.1_RNA|C21orf7_uc002ynd.2_RNA|C21orf7_uc010gln.2_RNA|C21orf7_uc002ynf.2_Missense_Mutation_p.A209P|C21orf7_uc010glo.2_Missense_Mutation_p.A54P|C21orf7_uc002yng.2_Missense_Mutation_p.A109P|C21orf7_uc010glp.2_RNA	NM_020152	NP_064537	P57077	TAK1L_HUMAN	chromosome 21 open reading frame 7	209						cytosol|nucleus	protein binding			ovary(2)	2				Colorectal(56;0.248)		GGAATTCGAGGCTCTGACGGA	0.522			NA											57	9					0	0	0.00361	0	0
DOPEY2	9980	broad.mit.edu	37	21	37642320	37642320	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:37642320C>G	uc002yvg.2	+	27	5576	c.5497C>G	c.(5497-5499)CAG>GAG	p.Q1833E	DOPEY2_uc011aeb.1_Missense_Mutation_p.Q1782E	NM_005128	NP_005119	Q9Y3R5	DOP2_HUMAN	pad-1-like	1833					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				ovary(1)|central_nervous_system(1)	2						GGAAATCACTCAGAAAATCCT	0.408			NA											201	28					0	0	0.00361	0	0
DSCAM	1826	broad.mit.edu	37	21	41446970	41446970	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:41446970G>T	uc002yyq.1	-	27	5334	c.4882C>A	c.(4882-4884)CTG>ATG	p.L1628M	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	1628	Cytoplasmic (Potential).				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTACCTCGCAGCCTCTTTAGC	0.607	Melanoma(134;970 1778 1785 21664 32388)		NA											28	4					8.88839e-20	1.30327e-19	0.002096	1	0
MX2	4600	broad.mit.edu	37	21	42767649	42767649	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:42767649G>T	uc002yzf.1	+	7	1111	c.1007G>T	c.(1006-1008)AGG>ATG	p.R336M	MX2_uc011aer.1_RNA|MX2_uc002yzg.1_Missense_Mutation_p.R59M	NM_002463	NP_002454	P20592	MX2_HUMAN	myxovirus resistance protein 2	336					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			ovary(2)	2		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				ATCACAAACAGGCTGAGCTTG	0.478			NA											55	12					1.54043e-34	2.64582e-34	0.00361	1	0
RRP1	8568	broad.mit.edu	37	21	45213224	45213224	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:45213224G>T	uc002zds.2	+	4	392	c.299G>T	c.(298-300)TGG>TTG	p.W100L	RRP1_uc011aez.1_Missense_Mutation_p.W100L|RRP1_uc010gpk.1_5'UTR|RRP1_uc010gpl.1_5'UTR	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	100					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CAGGCCTTCTGGCAGACCATG	0.602			NA											154	31					1.03023e-69	1.92508e-69	0.00361	1	0
C21orf29	54084	broad.mit.edu	37	21	45929249	45929249	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr21:45929249C>A	uc002zfe.1	-	10	1653	c.1587G>T	c.(1585-1587)TGG>TGT	p.W529C	C21orf29_uc010gpv.1_Missense_Mutation_p.W461C	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	529	EAR 5.				cell adhesion	extracellular region	structural molecule activity				0						GGAAGACCTCCCAGTCTGCAG	0.413			NA											35	4					8.69298e-16	1.1873e-15	0.006999	1	0
POTEH	23784	broad.mit.edu	37	22	16287400	16287400	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:16287400G>T	uc010gqp.2	-	1	538	c.486C>A	c.(484-486)GAC>GAA	p.D162E	POTEH_uc002zlg.1_RNA|POTEH_uc002zlh.1_5'UTR|POTEH_uc002zlj.1_5'UTR	NM_001136213	NP_001129685	Q6S545	POTEH_HUMAN	ANKRD26-like family C, member 3	162										skin(1)	1						TGAAAGCGCTGTCGTCGTAGT	0.592			NA											87	147					1.96202e-32	3.32272e-32	0.00361	1	0
CLTCL1	8218	broad.mit.edu	37	22	19203652	19203652	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:19203652C>A	uc002zpb.2	-	19	3109	c.3034G>T	c.(3034-3036)GTT>TTT	p.V1012F	CLTCL1_uc011agv.1_Missense_Mutation_p.V1012F|CLTCL1_uc011agw.1_Missense_Mutation_p.V1012F|CLTCL1_uc002zpe.2_5'Flank|CLTCL1_uc002zpd.1_5'Flank	NM_007098	NP_009029	P53675	CLH2_HUMAN	clathrin, heavy polypeptide-like 1 isoform 1	1012	Proximal segment.|Heavy chain arm.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			ovary(4)|central_nervous_system(1)	5	Colorectal(54;0.0993)					TTATCCAGAACTATCTTCTCC	0.473			NA	T	?	ALCL								52	3					1.17673e-23	1.83089e-23	0.00361	1	0
AIFM3	150209	broad.mit.edu	37	22	21329084	21329084	+	Nonsense_Mutation	SNP	C	C	A	rs138399322		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:21329084C>A	uc002ztj.2	+	8	917	c.699C>A	c.(697-699)TAC>TAA	p.Y233*	AIFM3_uc002ztk.2_Nonsense_Mutation_p.Y233*|AIFM3_uc002ztl.2_Nonsense_Mutation_p.Y239*|AIFM3_uc011ahx.1_Nonsense_Mutation_p.Y221*|AIFM3_uc002ztm.1_Nonsense_Mutation_p.Y45*	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	233					activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			ACCTTCCCTACGACCGTCCCA	0.627			NA											148	4					5.24422e-81	9.87567e-81	0.00361	1	0
GNAZ	2781	broad.mit.edu	37	22	23438545	23438545	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:23438545C>A	uc002zwu.1	+	2	1200	c.663C>A	c.(661-663)GCC>GCA	p.A221A	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	221						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GCGTCACAGCCATCATCTTCT	0.557			NA											405	29					4.57064e-181	8.6663e-181	0.00361	1	0
MYO18B	84700	broad.mit.edu	37	22	26294316	26294316	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26294316G>T	uc003abz.1	+	29	4961	c.4711G>T	c.(4711-4713)GCT>TCT	p.A1571S	MYO18B_uc003aca.1_Missense_Mutation_p.A1452S|MYO18B_uc010guy.1_Missense_Mutation_p.A1453S|MYO18B_uc010guz.1_Missense_Mutation_p.A1451S|MYO18B_uc011aka.1_Missense_Mutation_p.A725S|MYO18B_uc011akb.1_Missense_Mutation_p.A1084S	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1571	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CAAGAAGATGGCTCACCAACT	0.488			NA											104	8					2.97704e-61	5.52552e-61	0.00361	1	0
MYO18B	84700	broad.mit.edu	37	22	26422693	26422693	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26422693G>T	uc003abz.1	+	43	7003	c.6753G>T	c.(6751-6753)TCG>TCT	p.S2251S	MYO18B_uc003aca.1_Silent_p.S2132S|MYO18B_uc010guy.1_Silent_p.S2133S|MYO18B_uc010guz.1_Silent_p.S2131S|MYO18B_uc011aka.1_Silent_p.S1405S|MYO18B_uc011akb.1_Silent_p.S1764S|MYO18B_uc010gva.1_Silent_p.S234S|MYO18B_uc010gvb.1_RNA	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2251						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CGGCCCTCTCGGAGTTCGTGG	0.607			NA											41	1					6.5261e-18	9.28733e-18	0.00874	1	0
SEZ6L	23544	broad.mit.edu	37	22	26692873	26692873	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26692873C>A	uc003acb.2	+	4	1145	c.989C>A	c.(988-990)TCC>TAC	p.S330Y	SEZ6L_uc003acc.2_Missense_Mutation_p.S330Y|SEZ6L_uc011akc.1_Missense_Mutation_p.S330Y|SEZ6L_uc003acd.2_Missense_Mutation_p.S330Y|SEZ6L_uc011akd.1_Missense_Mutation_p.S330Y|SEZ6L_uc003ace.2_Missense_Mutation_p.S330Y|SEZ6L_uc003acf.1_Missense_Mutation_p.S103Y|SEZ6L_uc010gvc.1_Missense_Mutation_p.S103Y	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	330	CUB 1.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GTGAACCTGTCCGATGGGGAA	0.577			NA											40	4					8.16277e-20	1.19869e-19	0.006999	1	0
SEZ6L	23544	broad.mit.edu	37	22	26706660	26706660	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26706660C>T	uc003acb.2	+	7	1695	c.1539C>T	c.(1537-1539)ACC>ACT	p.T513T	SEZ6L_uc003acc.2_Silent_p.T513T|SEZ6L_uc011akc.1_Silent_p.T513T|SEZ6L_uc003acd.2_Silent_p.T513T|SEZ6L_uc011akd.1_Silent_p.T513T|SEZ6L_uc003ace.2_Silent_p.T513T|SEZ6L_uc003acf.1_Silent_p.T286T|SEZ6L_uc010gvc.1_Silent_p.T286T	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	513	CUB 2.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GCGGGCAGACCAACAAGTCAG	0.572			NA											133	9					0	0	0.00361	0	0
SEZ6L	23544	broad.mit.edu	37	22	26747053	26747053	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26747053T>A	uc003acb.2	+	12	2599	c.2443T>A	c.(2443-2445)TCG>ACG	p.S815T	SEZ6L_uc003acc.2_Missense_Mutation_p.S815T|SEZ6L_uc011akc.1_Missense_Mutation_p.S815T|SEZ6L_uc003acd.2_Intron|SEZ6L_uc011akd.1_Missense_Mutation_p.S815T|SEZ6L_uc003ace.2_Missense_Mutation_p.S815T|SEZ6L_uc003acf.1_Missense_Mutation_p.S588T|SEZ6L_uc010gvc.1_Missense_Mutation_p.S588T|SEZ6L_uc011ake.1_RNA	NM_021115	NP_066938	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	815	Sushi 4.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(4)|central_nervous_system(1)|pancreas(1)	6						GGTGGATCACTCGACCCGCTT	0.542			NA											8	159					0	0	0.006214	0	0
SRRD	402055	broad.mit.edu	37	22	26887615	26887615	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26887615G>T	uc010gve.2	+	7	1004	c.997G>T	c.(997-999)GAA>TAA	p.E333*	SRRD_uc003acp.3_Nonsense_Mutation_p.E326*|uc003acu.1_5'Flank	NM_001013694	NP_001013716	Q9UH36	SRR1L_HUMAN	SRR1 domain containing	333					rhythmic process						0						GAACAAGAGAGAAGATCCTTC	0.468			NA											9	58					2.74318e-10	3.35779e-10	0.006214	1	0
TPST2	8459	broad.mit.edu	37	22	26936942	26936942	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:26936942C>A	uc003acv.2	-	2	823	c.655G>T	c.(655-657)GAG>TAG	p.E219*	TPST2_uc003acw.2_Nonsense_Mutation_p.E219*|TPST2_uc003acx.2_Nonsense_Mutation_p.E219*|TPST2_uc011akf.1_Nonsense_Mutation_p.E219*	NM_003595	NP_003586	O60704	TPST2_HUMAN	tyrosylprotein sulfotransferase 2	219	Lumenal (Potential).				peptidyl-tyrosine sulfation	endoplasmic reticulum|Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			central_nervous_system(1)	1						TACATCACCTCGATGGCCTTG	0.597			NA											19	62					1.01871e-10	1.2557e-10	0.008871	1	0
MN1	4330	broad.mit.edu	37	22	28192875	28192875	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:28192875C>A	uc003adj.2	-	1	4612	c.3657G>T	c.(3655-3657)CTG>CTT	p.L1219L		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1219							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						GCTCTGCCATCAGCGAGTCCA	0.667			NA	T	ETV6	AML|meningioma								100	8					5.78178e-49	1.05094e-48	0.00361	1	0
MN1	4330	broad.mit.edu	37	22	28193258	28193258	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:28193258C>A	uc003adj.2	-	1	4229	c.3274G>T	c.(3274-3276)GGG>TGG	p.G1092W		NM_002430	NP_002421	Q10571	MN1_HUMAN	meningioma  1	1092							binding			central_nervous_system(3)|lung(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	10						CCGTGTTCCCCGGCGCCTACC	0.697			NA	T	ETV6	AML|meningioma								27	1					3.6726e-16	5.03746e-16	0.003954	1	0
CCDC117	150275	broad.mit.edu	37	22	29182289	29182289	+	Missense_Mutation	SNP	G	G	T	rs9613680		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:29182289G>T	uc003aeb.2	+	5	991	c.815G>T	c.(814-816)AGC>ATC	p.S272I	CCDC117_uc011aki.1_Missense_Mutation_p.S254I|CCDC117_uc011akj.1_Missense_Mutation_p.S197I|CCDC117_uc011akk.1_Missense_Mutation_p.S140I	NM_173510	NP_775781	Q8IWD4	CC117_HUMAN	coiled-coil domain containing 117	272										breast(1)	1						ACAGCTACTAGCACAGAAGAA	0.418			NA											62	9					1.1362e-29	1.8878e-29	0.00361	1	0
RFPL1	5988	broad.mit.edu	37	22	29834927	29834927	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:29834927A>C	uc003afn.2	+	1	356	c.147A>C	c.(145-147)AAA>AAC	p.K49N	RFPL1S_uc003afm.1_RNA	NM_021026	NP_066306	O75677	RFPL1_HUMAN	ret finger protein-like 1	49	RING-type.						zinc ion binding				0						ATCTAGAGAAACCAATGTCCC	0.512			NA											69	11					0	0	0.00361	0	0
TBC1D10A	83874	broad.mit.edu	37	22	30688566	30688566	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:30688566C>A	uc011akt.1	-	11	1349	c.1325G>T	c.(1324-1326)AGA>ATA	p.R442I	GATSL3_uc003ahc.2_5'Flank|GATSL3_uc003ahe.2_5'Flank|GATSL3_uc003ahd.2_5'Flank|GATSL3_uc003ahf.2_Intron|GATSL3_uc003ahg.2_Intron|GATSL3_uc003ahh.2_Intron|GATSL3_uc010gvq.2_Intron|GATSL3_uc003ahi.2_Intron|GATSL3_uc010gvr.2_5'Flank|GATSL3_uc010gvs.2_5'Flank|TBC1D10A_uc003ahj.3_Missense_Mutation_p.R354I|TBC1D10A_uc010gvu.2_Missense_Mutation_p.R449I|TBC1D10A_uc003ahk.3_Missense_Mutation_p.R442I	NM_031937	NP_114143	Q9BXI6	TB10A_HUMAN	TBC1 domain family, member 10A	442						intracellular|microvillus	guanyl-nucleotide exchange factor activity|PDZ domain binding|Rab GTPase activator activity			ovary(1)	1						CAGCTGCCCTCTCCCCTTCAT	0.647			NA											88	11					3.90494e-43	6.97982e-43	0.00361	1	0
APOL3	80833	broad.mit.edu	37	22	36556832	36556832	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:36556832T>C	uc003aot.2	-	1	146	c.108A>G	c.(106-108)ATA>ATG	p.I36M	APOL3_uc003aoq.2_Translation_Start_Site|APOL3_uc003aor.2_Translation_Start_Site|APOL3_uc003aos.2_Translation_Start_Site|APOL3_uc003aou.2_Translation_Start_Site|APOL3_uc003aov.2_Translation_Start_Site	NM_145640	NP_663615	O95236	APOL3_HUMAN	apolipoprotein L3 isoform 1	36					inflammatory response|lipoprotein metabolic process|positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	lipid binding|lipid transporter activity|signal transducer activity				0						GGCTCTGAGATATACCCTGGA	0.517			NA											40	8					0	0	0.007835	0	0
CSF2RB	1439	broad.mit.edu	37	22	37334022	37334022	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:37334022G>T	uc003aqa.3	+	14	2389	c.2172G>T	c.(2170-2172)GGG>GGT	p.G724G	CSF2RB_uc003aqc.3_Silent_p.G730G	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	724	Cytoplasmic (Potential).				respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	CAAACTCAGGGGCCTCGTCTG	0.632			NA											83	18					5.01286e-43	8.95186e-43	0.00361	1	0
TST	7263	broad.mit.edu	37	22	37407135	37407135	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:37407135C>A	uc003aqg.2	-	2	1527	c.827G>T	c.(826-828)TGG>TTG	p.W276L	TST_uc003aqh.2_Missense_Mutation_p.W276L	NM_003312	NP_003303	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase	276	Rhodanese 2.				cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity				0						CCACTCGGACCAGGAGCCATC	0.642			NA											22	37					0.000295444	0.000312234	0.002299	1	0
PLA2G6	8398	broad.mit.edu	37	22	38524306	38524306	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:38524306G>A	uc003auy.1	-	9	1454	c.1318C>T	c.(1318-1320)CAG>TAG	p.Q440*	PLA2G6_uc003auz.1_Intron|PLA2G6_uc003ava.1_Nonsense_Mutation_p.Q440*|PLA2G6_uc003avb.2_Intron|PLA2G6_uc010gxk.1_RNA|PLA2G6_uc011ano.1_Nonsense_Mutation_p.Q405*	NM_003560	NP_003551	O60733	PA2G6_HUMAN	phospholipase A2, group VI isoform a	440					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				ovary(1)	1	Melanoma(58;0.045)				Quinacrine(DB01103)	GGTGGGGGCTGAGCTCTTTCC	0.652			NA											14	18					0	0	0.003163	0	0
TOMM22	56993	broad.mit.edu	37	22	39079772	39079772	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:39079772A>G	uc003awe.2	+	4	385	c.355A>G	c.(355-357)ATA>GTA	p.I119V	uc003awd.2_5'Flank	NM_020243	NP_064628	Q9NS69	TOM22_HUMAN	mitochondrial import receptor Tom22	119	Mitochondrial intermembrane (Potential).				protein import into mitochondrial outer membrane	integral to membrane|integral to membrane of membrane fraction|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity|receptor activity				0	Melanoma(58;0.04)					TCTTTTCCAGATACTTCTAGG	0.463			NA											25	36					0	0	0.004656	0	0
ENTHD1	150350	broad.mit.edu	37	22	40139884	40139884	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:40139884G>C	uc003ayg.2	-	7	1875	c.1624C>G	c.(1624-1626)CCT>GCT	p.P542A		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	542										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					TTTGCTTCAGGTTCCTGGGGG	0.438			NA											11	17					0	0	0.008291	0	0
MPPED1	758	broad.mit.edu	37	22	43898595	43898595	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:43898595C>A	uc011apv.1	+	6	1043	c.820C>A	c.(820-822)CGC>AGC	p.R274S	MPPED1_uc011apw.1_Missense_Mutation_p.R168S|MPPED1_uc011apx.1_Missense_Mutation_p.R116S|MPPED1_uc011apy.1_Missense_Mutation_p.R274S|MPPED1_uc011apz.1_Missense_Mutation_p.R307S	NM_001044370	NP_001037835	O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	274							hydrolase activity				0		all_neural(38;0.0244)|Ovarian(80;0.0694)				GGTGCAGAGGCGCGTCCAGCC	0.617			NA											56	15					2.01871e-26	3.25078e-26	0.00361	1	0
EFCAB6	64800	broad.mit.edu	37	22	44131757	44131757	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:44131757T>A	uc003bdy.1	-	7	839	c.624A>T	c.(622-624)TTA>TTT	p.L208F	EFCAB6_uc003bdz.1_Missense_Mutation_p.L56F|EFCAB6_uc010gzi.1_Missense_Mutation_p.L56F|EFCAB6_uc011aqa.1_Missense_Mutation_p.L102F|EFCAB6_uc003bea.1_Missense_Mutation_p.L205F|EFCAB6_uc003beb.3_Missense_Mutation_p.L102F	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				CCTCGTCTCTTAACTTCATAC	0.428			NA											60	12					0	0	0.00361	0	0
FBLN1	2192	broad.mit.edu	37	22	45914600	45914600	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:45914600G>A	uc003bgj.1	+	2	265	c.118G>A	c.(118-120)GGA>AGA	p.G40R	FBLN1_uc003bgg.1_Missense_Mutation_p.G40R|FBLN1_uc003bgh.2_Missense_Mutation_p.G40R|FBLN1_uc010gzz.2_Missense_Mutation_p.G40R|FBLN1_uc003bgi.1_Missense_Mutation_p.G40R	NM_006486	NP_006477	P23142	FBLN1_HUMAN	fibulin 1 isoform D	40	Anaphylatoxin-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(1)|central_nervous_system(1)	2		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		CTGTGCGGACGGACACCGGAT	0.597			NA											3	8					0	0	0.009096	0	0
CHL1	10752	broad.mit.edu	37	3	419519	419519	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:419519T>A	uc003bou.2	+	15	1993	c.1722T>A	c.(1720-1722)GCT>GCA	p.A574A	CHL1_uc003bot.2_Silent_p.A590A|CHL1_uc003bow.1_Silent_p.A574A|CHL1_uc011asi.1_Silent_p.A590A|uc003box.1_Intron	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	574	Ig-like C2-type 6.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTGATGGAGCTAATTTGACCA	0.338			NA											42	4					0	0	0.00874	0	0
CHL1	10752	broad.mit.edu	37	3	433372	433372	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:433372A>T	uc003bou.2	+	22	3029	c.2758A>T	c.(2758-2760)ACT>TCT	p.T920S	CHL1_uc003bot.2_Missense_Mutation_p.T936S|CHL1_uc003bow.1_Missense_Mutation_p.T920S|CHL1_uc011asi.1_Missense_Mutation_p.T936S	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	920	Fibronectin type-III 4.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TGAACAGCCAACTTTTCTAAA	0.294			NA											32	6					0	0	0.003271	0	0
CHL1	10752	broad.mit.edu	37	3	447347	447347	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:447347G>A	uc003bou.2	+	27	3851	c.3580G>A	c.(3580-3582)GTT>ATT	p.V1194I	CHL1_uc003bot.2_Missense_Mutation_p.V1210I|CHL1_uc011asi.1_Missense_Mutation_p.V1157I	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	1194	Cytoplasmic (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GAAGGGATCTGTTGAAAGCAA	0.453			NA											35	7					0	0	0.005524	0	0
GRM7	2917	broad.mit.edu	37	3	7494358	7494358	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:7494358C>T	uc003bqm.2	+	6	1513	c.1239C>T	c.(1237-1239)GAC>GAT	p.D413D	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.D413D|GRM7_uc003bql.2_Silent_p.D413D|GRM7_uc003bqn.1_Translation_Start_Site|GRM7_uc010hch.1_Translation_Start_Site	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	413	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TCGTGATTGACGCAGTCTATG	0.453			NA											26	6					0	0	0.003954	0	0
ATP2B2	491	broad.mit.edu	37	3	10392241	10392241	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:10392241C>A	uc003bvt.2	-	15	2596	c.2157G>T	c.(2155-2157)AAG>AAT	p.K719N	ATP2B2_uc003bvv.2_Missense_Mutation_p.K674N|ATP2B2_uc003bvw.2_Missense_Mutation_p.K674N|ATP2B2_uc010hdo.2_Missense_Mutation_p.K424N	NM_001001331	NP_001001331	Q01814	AT2B2_HUMAN	plasma membrane calcium ATPase 2 isoform 1	719	Cytoplasmic (Potential).				ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|ATP binding|calcium ion binding|calcium-transporting ATPase activity|calcium-transporting ATPase activity|calmodulin binding|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			ovary(3)|skin(2)|central_nervous_system(1)	6						CCCGCTGGCACTTGCGGATGG	0.647	Ovarian(125;1619 1709 15675 19819 38835)		NA											57	8					2.67592e-24	4.20067e-24	0.00361	1	0
NUP210	23225	broad.mit.edu	37	3	13401954	13401954	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:13401954C>A	uc003bxv.1	-	15	2053	c.1970G>T	c.(1969-1971)GGC>GTC	p.G657V	NUP210_uc003bxx.2_Missense_Mutation_p.G329V	NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	657	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					CTTTGAGGAGCCCAGGGTTAC	0.572			NA											16	6					1.15088e-07	1.32252e-07	0.004007	1	0
KCNH8	131096	broad.mit.edu	37	3	19479673	19479673	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:19479673G>T	uc003cbk.1	+	8	1390	c.1195G>T	c.(1195-1197)GGA>TGA	p.G399*	KCNH8_uc011awe.1_Nonsense_Mutation_p.G399*|KCNH8_uc010hex.1_5'UTR|KCNH8_uc011awf.1_Nonsense_Mutation_p.G30*	NM_144633	NP_653234	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H,	399	Extracellular (Potential).					integral to membrane	two-component sensor activity			lung(4)|ovary(1)	5						TCATGAGTTGGGAAAGAGACT	0.443	NSCLC(124;1625 1765 8018 24930 42026)		NA											186	32					1.2754e-92	2.41117e-92	0.00361	1	0
NEK10	152110	broad.mit.edu	37	3	27233735	27233735	+	Splice_Site	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:27233735T>A	uc010hfk.2	-	5	457	c.228_splice	c.e5-1	p.R76_splice	NEK10_uc003cds.1_Splice_Site_p.R161_splice|NEK10_uc010hfj.2_Splice_Site_p.R76_splice			Q6ZWH5	NEK10_HUMAN	RecName: Full=Serine/threonine-protein kinase Nek10;          EC=2.7.11.1; AltName: Full=NimA-related protein kinase 10;								ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(5)|stomach(2)|central_nervous_system(2)|lung(2)|skin(1)|pancreas(1)	13						GTGAGGCACCTAAGATAACAT	0.413			NA											10	19					0	0	0.008291	0	0
TRANK1	9881	broad.mit.edu	37	3	36897117	36897117	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:36897117C>A	uc003cgj.2	-	3	2616	c.2314G>T	c.(2314-2316)GGG>TGG	p.G772W		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1322					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						GTGAGTCTCCCATGGGGACAG	0.448			NA											107	15					2.01602e-52	3.69572e-52	0.00361	1	0
TRANK1	9881	broad.mit.edu	37	3	36897470	36897470	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:36897470T>A	uc003cgj.2	-	3	2263	c.1961A>T	c.(1960-1962)CAG>CTG	p.Q654L		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	1204					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						AAGAAGCAGCTGCTTGGAAGT	0.468			NA											164	19					0	0	0.00361	0	0
LRRFIP2	9209	broad.mit.edu	37	3	37170591	37170591	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:37170591T>A	uc003cgp.2	-	4	563	c.140A>T	c.(139-141)GAT>GTT	p.D47V	LRRFIP2_uc011ayf.1_Missense_Mutation_p.D47V|LRRFIP2_uc003cgr.2_Missense_Mutation_p.D47V|LRRFIP2_uc003cgs.3_Missense_Mutation_p.D47V|LRRFIP2_uc003cgt.3_Missense_Mutation_p.D47V	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	47	DVL3-binding.|Potential.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						CATGCGTATATCTCTTGCTTC	0.413			NA											100	20					0	0	0.00361	0	0
C3orf35	339883	broad.mit.edu	37	3	37458927	37458927	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:37458927G>T	uc003cha.3	+	5	834	c.170G>T	c.(169-171)GGC>GTC	p.G57V	C3orf35_uc003chb.2_Missense_Mutation_p.G57V	NM_178339	NP_848029	Q8IVJ8	APRG1_HUMAN	AP20 region protein isoform B	57						integral to membrane				central_nervous_system(1)	1						GAGCAGATGGGCCTGCAGGGC	0.453			NA											50	8					3.39706e-21	5.12873e-21	0.00361	1	0
OXSR1	9943	broad.mit.edu	37	3	38266060	38266060	+	Splice_Site	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:38266060A>G	uc003chy.2	+	8	1045	c.703_splice	c.e8-2	p.V235_splice	OXSR1_uc010hhb.2_Splice_Site_p.V169_splice|OXSR1_uc010hha.1_Splice_Site_p.V167_splice	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1						intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		AAATTCTTGCAGGTTTTAATG	0.264			NA											41	6					0	0	0.009718	0	0
SCN5A	6331	broad.mit.edu	37	3	38592067	38592067	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:38592067C>A	uc003cio.2	-	28	5990	c.5796G>T	c.(5794-5796)GCG>GCT	p.A1932A	SCN5A_uc003cin.2_Silent_p.A1931A|SCN5A_uc003cil.3_Silent_p.A1932A|SCN5A_uc010hhi.2_Silent_p.A1914A|SCN5A_uc010hhk.2_Silent_p.A1899A|SCN5A_uc011ayr.1_Silent_p.A1878A	NM_198056	NP_932173	Q14524	SCN5A_HUMAN	voltage-gated sodium channel type V alpha	1932					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			ovary(4)|pancreas(2)|skin(2)|central_nervous_system(1)	9	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGCCGCTGCCCGCCTGCTGAC	0.622			NA											48	12					1.00953e-15	1.37495e-15	0.003214	1	0
SCN10A	6336	broad.mit.edu	37	3	38766770	38766770	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:38766770G>T	uc003ciq.2	-	17	3123	c.3123C>A	c.(3121-3123)GAC>GAA	p.D1041E		NM_006514	NP_006505	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha	1041					sensory perception	voltage-gated sodium channel complex				ovary(5)|skin(3)|large_intestine(1)|kidney(1)	10				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTGTCAGGTGGTCCCCACACC	0.577			NA											34	4					5.8336e-16	7.97892e-16	0.003271	1	0
ZNF445	353274	broad.mit.edu	37	3	44488673	44488673	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:44488673C>A	uc003cnf.2	-	8	2838	c.2490G>T	c.(2488-2490)GAG>GAT	p.E830D	ZNF445_uc011azv.1_Missense_Mutation_p.E818D|ZNF445_uc011azw.1_Missense_Mutation_p.E830D	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	830					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GGATTTTTGGCTCCACATTTG	0.403			NA											85	18					1.52804e-57	2.81987e-57	0.00361	1	0
DHX30	22907	broad.mit.edu	37	3	47890012	47890012	+	Silent	SNP	C	C	T	rs79236789		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:47890012C>T	uc003cru.2	+	16	2973	c.2547C>T	c.(2545-2547)GAC>GAT	p.D849D	DHX30_uc003crt.2_Silent_p.D810D|MIR1226_hsa-mir-1226|MI0006313_5'Flank	NM_138615	NP_619520	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 30	849						mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		AGGCAGTGGACGAGGCTGTGA	0.527			NA											46	103					0	0	0.00361	0	0
USP19	10869	broad.mit.edu	37	3	49148462	49148462	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:49148462C>A	uc003cwd.1	-	22	3318	c.3157G>T	c.(3157-3159)GCC>TCC	p.A1053S	USP19_uc003cwa.2_Missense_Mutation_p.A861S|USP19_uc003cvz.3_Missense_Mutation_p.A1156S|USP19_uc011bcg.1_Missense_Mutation_p.A1144S|USP19_uc003cwb.2_Intron|USP19_uc003cwc.1_Missense_Mutation_p.A811S|USP19_uc011bch.1_Missense_Mutation_p.A1154S	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	1053	Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCGGCCCGGGCAGCCTCACCG	0.622			NA											60	11					1.19403e-26	1.9276e-26	0.00361	1	0
HYAL1	3373	broad.mit.edu	37	3	50338129	50338129	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:50338129C>T	uc003czp.2	-	4	1225	c.1093G>A	c.(1093-1095)GGC>AGC	p.G365S	HYAL3_uc003czc.1_5'Flank|HYAL3_uc003czd.1_5'Flank|HYAL3_uc003cze.1_5'Flank|HYAL3_uc003czf.1_5'Flank|HYAL3_uc003czg.1_5'Flank|NAT6_uc003czi.2_5'Flank|NAT6_uc003czj.2_5'Flank|NAT6_uc003czk.3_5'Flank|NAT6_uc003czl.1_5'Flank|HYAL1_uc003czm.2_Missense_Mutation_p.G183S|HYAL1_uc003czo.2_Missense_Mutation_p.G106S|HYAL1_uc003czq.2_Missense_Mutation_p.G335S|HYAL1_uc003czr.2_Missense_Mutation_p.G365S|HYAL1_uc003czn.2_Missense_Mutation_p.G26S|HYAL1_uc003czs.2_Missense_Mutation_p.G365S|HYAL1_uc003czt.2_3'UTR	NM_033159	NP_149349	Q12794	HYAL1_HUMAN	hyaluronoglucosaminidase 1 isoform 1	365	EGF-like.					extracellular space|lysosome	hyalurononglucosaminidase activity			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)	Hyaluronidase(DB00070)	CGGCCATGGCCGGAGCACAGG	0.617			NA											15	3					0	0	0.00245	0	0
PARP3	10039	broad.mit.edu	37	3	51979203	51979203	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:51979203C>A	uc003dby.2	+	6	1195	c.824C>A	c.(823-825)TCC>TAC	p.S275Y	PARP3_uc003dbz.2_Missense_Mutation_p.S282Y	NM_005485	NP_005476	Q9Y6F1	PARP3_HUMAN	poly (ADP-ribose) polymerase family, member 3	275	PARP alpha-helical.				DNA repair|protein ADP-ribosylation	centriole|nucleus	NAD+ ADP-ribosyltransferase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCCATCAATTCCCCTGAGCTT	0.642			NA											66	18					1.19759e-16	1.65675e-16	0.00361	1	0
FLNB	2317	broad.mit.edu	37	3	58140568	58140568	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:58140568G>T	uc003djj.2	+	40	6850	c.6685G>T	c.(6685-6687)GCT>TCT	p.A2229S	FLNB_uc010hne.2_Missense_Mutation_p.A2260S|FLNB_uc003djk.2_Missense_Mutation_p.A2218S|FLNB_uc010hnf.2_Missense_Mutation_p.A2205S|FLNB_uc003djl.2_Missense_Mutation_p.A2049S|FLNB_uc003djm.2_Missense_Mutation_p.A2036S	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	2229	Interaction with INPPL1.|Filamin 21.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		CCTCTCCATCGCTGTTGAGGG	0.537			NA											54	8					2.12129e-23	3.28468e-23	0.00361	1	0
CADPS	8618	broad.mit.edu	37	3	62860663	62860663	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:62860663G>C	uc003dll.2	-	1	402	c.42C>G	c.(40-42)ATC>ATG	p.I14M	CADPS_uc003dlm.2_Missense_Mutation_p.I14M|CADPS_uc003dln.2_Missense_Mutation_p.I14M	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	14					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CCTCCTCCACGATCTCATCCG	0.706			NA											7	2					0	0	0.00308	0	0
C3orf64	285203	broad.mit.edu	37	3	69058943	69058943	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:69058943G>C	uc003dnl.2	-	4	460	c.55C>G	c.(55-57)CAG>GAG	p.Q19E	C3orf64_uc003dnk.2_Missense_Mutation_p.Q19E|C3orf64_uc011bfw.1_RNA|C3orf64_uc003dnm.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	19						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		GCTTCATTCTGACCACTCAGT	0.428			NA											24	3					0	0	0.004656	0	0
LMOD3	56203	broad.mit.edu	37	3	69168080	69168080	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:69168080G>A	uc003dns.2	-	2	1635	c.1426C>T	c.(1426-1428)CCG>TCG	p.P476S	LMOD3_uc003dnt.2_Missense_Mutation_p.P476S	NM_198271	NP_938012	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	476						cytoplasm|cytoskeleton	tropomyosin binding			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		CTGTACTTCGGGGCCTGCGAT	0.552			NA											26	9					0	0	0.003954	0	0
PDZRN3	23024	broad.mit.edu	37	3	73657747	73657747	+	Splice_Site	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:73657747A>G	uc003dpl.1	-	2	906	c.810_splice	c.e2+1	p.V270_splice		NM_015009	NP_055824	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3								ubiquitin-protein ligase activity|zinc ion binding			pancreas(2)|ovary(2)|skin(2)|large_intestine(1)	7		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TAATTAACATACCACACTCGG	0.478			NA											5	3					0	0	0.001168	0	0
EPHA3	2042	broad.mit.edu	37	3	89390085	89390085	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:89390085C>A	uc003dqy.2	+	4	1059	c.834C>A	c.(832-834)TAC>TAA	p.Y278*	EPHA3_uc003dqx.1_Nonsense_Mutation_p.Y278*|EPHA3_uc010hon.1_RNA	NM_005233	NP_005224	P29320	EPHA3_HUMAN	ephrin receptor EphA3 isoform a precursor	278	Extracellular (Potential).|Cys-rich.					extracellular region|integral to plasma membrane	ATP binding			lung(17)|ovary(7)|large_intestine(4)|central_nervous_system(2)|stomach(1)|skin(1)|pancreas(1)	33	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		CAGGTTTCTACAAGGCATTGG	0.363			NA								TSP Lung(6;0.00050)			58	15					1.14385e-22	1.75433e-22	0.00361	1	0
PROS1	5627	broad.mit.edu	37	3	93603583	93603583	+	Missense_Mutation	SNP	T	T	G	rs5017713		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:93603583T>G	uc003drb.3	-	12	1822	c.1481A>C	c.(1480-1482)CAC>CCC	p.H494P	PROS1_uc010hoo.2_Missense_Mutation_p.H363P|PROS1_uc003dqz.3_Missense_Mutation_p.H363P	NM_000313	NP_000304	P07225	PROS_HUMAN	protein S, alpha preproprotein	494	Laminin G-like 2.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			large_intestine(1)	1					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ATAATCTATGTGAAATTGAGC	0.274			NA											7	24					0	0	0.004482	0	0
COL8A1	1295	broad.mit.edu	37	3	99514012	99514012	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:99514012G>A	uc003dtg.1	+	5	1512	c.1267G>A	c.(1267-1269)GGG>AGG	p.G423R	COL8A1_uc003dth.1_Missense_Mutation_p.G423R|COL8A1_uc003dti.1_Missense_Mutation_p.G424R	NM_001850	NP_001841	P27658	CO8A1_HUMAN	alpha 1 type VIII collagen precursor	423	Triple-helical region (COL1).				angiogenesis|cell adhesion	basement membrane|collagen type VIII					0						AGGGCCACAGGGGCCACCAGG	0.607			NA											17	40					0	0	0.006122	0	0
ABI3BP	25890	broad.mit.edu	37	3	100621464	100621464	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:100621464G>T	uc003dun.2	-	3	432	c.347C>A	c.(346-348)TCA>TAA	p.S116*	ABI3BP_uc003duo.2_Nonsense_Mutation_p.S109*|ABI3BP_uc003dup.3_Nonsense_Mutation_p.S109*	NM_015429	NP_056244	Q7Z7G0	TARSH_HUMAN	ABI gene family, member 3 (NESH) binding protein	116						extracellular space				ovary(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)	4						GACTATACCTGAACATGACTT	0.398			NA											7	11					2.0095e-06	2.2374e-06	0.001984	1	0
SENP7	57337	broad.mit.edu	37	3	101047391	101047391	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:101047391C>A	uc003dut.2	-	22	2907	c.2796_splice	c.e22-1	p.R932_splice	SENP7_uc003duu.2_Splice_Site_p.R867_splice|SENP7_uc003duv.2_Splice_Site_p.R899_splice|SENP7_uc003duw.2_Splice_Site_p.R866_splice|SENP7_uc003dux.2_Splice_Site_p.R768_splice|SENP7_uc003dus.2_Splice_Site_p.R120_splice	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1						proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						AATACATGGCCTATGAAAAGC	0.318			NA											31	97					7.11191e-15	9.49891e-15	0.002836	1	0
CBLB	868	broad.mit.edu	37	3	105495359	105495359	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:105495359G>C	uc003dwc.2	-	4	769	c.447C>G	c.(445-447)ATC>ATG	p.I149M	CBLB_uc011bhi.1_Missense_Mutation_p.I171M|CBLB_uc003dwd.1_Missense_Mutation_p.I149M|CBLB_uc003dwe.1_Missense_Mutation_p.I149M|CBLB_uc011bhj.1_Intron	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	149	Cbl-PTB.|4H.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TGTGACTGAAGATAAGGGACA	0.373	GBM(93;588 1337 9788 29341 43499)		NA	Mis S		AML								11	35					0	0	0.00245	0	0
CCDC54	84692	broad.mit.edu	37	3	107096857	107096857	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:107096857A>G	uc003dwi.1	+	1	670	c.423A>G	c.(421-423)ACA>ACG	p.T141T		NM_032600	NP_115989	Q8NEL0	CCD54_HUMAN	coiled-coil domain containing 54	141	Potential.										0						AGAAGGTGACAGAACTGGAAA	0.383			NA											11	36					0	0	0.008291	0	0
DZIP3	9666	broad.mit.edu	37	3	108363525	108363525	+	Missense_Mutation	SNP	G	G	T	rs145724685	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:108363525G>T	uc003dxd.2	+	14	2078	c.1656G>T	c.(1654-1656)GAG>GAT	p.E552D	DZIP3_uc003dxf.1_Missense_Mutation_p.E552D|DZIP3_uc011bhm.1_Missense_Mutation_p.E3D|DZIP3_uc003dxe.1_Missense_Mutation_p.E552D|DZIP3_uc003dxg.1_Missense_Mutation_p.E275D	NM_014648	NP_055463	Q86Y13	DZIP3_HUMAN	DAZ interacting protein 3, zinc finger	552					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AAGTGAAGGAGAATCCCATTG	0.403			NA											25	58					1.1804e-14	1.57224e-14	0.003954	1	0
CD96	10225	broad.mit.edu	37	3	111343206	111343206	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:111343206G>T	uc003dxw.2	+	11	1494	c.1324G>T	c.(1324-1326)GGC>TGC	p.G442C	CD96_uc003dxx.2_Missense_Mutation_p.G426C|CD96_uc010hpy.1_Missense_Mutation_p.G426C	NM_198196	NP_937839	P40200	TACT_HUMAN	CD96 antigen isoform 1 precursor	442	Extracellular (Potential).|Pro/Ser/Thr-rich.				cell adhesion|immune response|regulation of immune response	integral to plasma membrane				skin(2)|central_nervous_system(1)	3						GACTACCCGAGGCTTCAACTA	0.388			NA							Opitz_Trigonocephaly_syndrome				22	15					9.95505e-16	1.35681e-15	0.002299	1	0
GCET2	257144	broad.mit.edu	37	3	111845856	111845856	+	Missense_Mutation	SNP	C	C	A	rs150928109		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:111845856C>A	uc003dys.1	-	4	318	c.168G>T	c.(166-168)AAG>AAT	p.K56N	C3orf52_uc011bht.1_Intron|C3orf52_uc003dyr.1_Intron|GCET2_uc003dyt.1_5'UTR	NM_152785	NP_689998	Q8N6F7	GCET2_HUMAN	germinal center expressed transcript 2 isoform	56						mitochondrion					0						AATCTTGCCTCTTTTCAAAAA	0.269			NA											12	23					1.49906e-05	1.63796e-05	0.00245	1	0
WDR52	55779	broad.mit.edu	37	3	113125860	113125860	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:113125860C>T	uc003eae.1	-	8	965	c.919G>A	c.(919-921)GGT>AGT	p.G307S		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	307	WD 2.									central_nervous_system(1)	1						AGCTTGAGACCGGTGAACGTA	0.403			NA											38	34					0	0	0.002522	0	0
GRAMD1C	54762	broad.mit.edu	37	3	113563455	113563455	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:113563455G>T	uc003eaq.3	+	2	209	c.133G>T	c.(133-135)GGG>TGG	p.G45W	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	45						integral to membrane				ovary(2)|skin(1)	3						TAAAAAACAGGGGCCAAATTT	0.363			NA											41	33					1.62957e-23	2.5314e-23	0.00874	1	0
ZNF80	7634	broad.mit.edu	37	3	113955588	113955588	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:113955588T>C	uc010hqo.2	-	1	838	c.334A>G	c.(334-336)AAG>GAG	p.K112E	ZNF80_uc003ebf.2_RNA	NM_007136	NP_009067	P51504	ZNF80_HUMAN	zinc finger protein 80	112	C2H2-type 3; atypical.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Lung NSC(201;0.0233)|all_neural(597;0.0837)				TTGAAGACCTTCCCGCACTCC	0.547	GBM(23;986 1114 21716)		NA											16	29					0	0	0.007413	0	0
TIGIT	201633	broad.mit.edu	37	3	114018486	114018486	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:114018486C>A	uc003ebg.1	+	3	468	c.434C>A	c.(433-435)GCC>GAC	p.A145D		NM_173799	NP_776160	Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	145	Helical; (Potential).				negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)	1						TTGCTTGGAGCCATGGCCGCG	0.572			NA											14	52					5.01169e-05	5.42396e-05	0.00499	1	0
ZBTB20	26137	broad.mit.edu	37	3	114070047	114070047	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:114070047T>G	uc003ebi.2	-	4	1058	c.878A>C	c.(877-879)GAG>GCG	p.E293A	ZBTB20_uc003ebj.2_Missense_Mutation_p.E220A|ZBTB20_uc010hqp.2_Missense_Mutation_p.E220A|ZBTB20_uc003ebk.2_Missense_Mutation_p.E220A|ZBTB20_uc003ebl.2_Missense_Mutation_p.E220A|ZBTB20_uc003ebm.2_Missense_Mutation_p.E220A|ZBTB20_uc003ebn.2_Missense_Mutation_p.E220A|uc003ebo.1_5'Flank	NM_015642	NP_056457	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20 isoform	293					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|skin(1)	5				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CTGCGAGCGCTCATGGATGCG	0.657	NSCLC(69;748 1344 9802 11203 30933)		NA											64	31					0	0	0.00361	0	0
LSAMP	4045	broad.mit.edu	37	3	115561343	115561343	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:115561343C>T	uc003ebt.2	-	5	1232	c.732G>A	c.(730-732)GTG>GTA	p.V244V	LSAMP_uc011bis.1_Silent_p.V244V	NM_002338	NP_002329	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	244	Ig-like C2-type 3.				cell adhesion|nervous system development	anchored to membrane|plasma membrane					0		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		CAGGTGCAGGCACTGCCGAGG	0.547			NA											22	22					0	0	0.00333	0	0
IGSF11	152404	broad.mit.edu	37	3	118623535	118623535	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:118623535T>A	uc003ebw.2	-	6	1061	c.814A>T	c.(814-816)AAT>TAT	p.N272Y	IGSF11_uc011biv.1_Missense_Mutation_p.N244Y|IGSF11_uc003ebx.2_Missense_Mutation_p.N248Y|IGSF11_uc003eby.2_Missense_Mutation_p.N271Y|IGSF11_uc003ebz.2_Missense_Mutation_p.N247Y|IGSF11_uc010hqs.2_Missense_Mutation_p.N271Y	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	272	Cytoplasmic (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						TCCTCTTTATTTTTGCTTCTC	0.343			NA											49	251					0	0	0.00361	0	0
IGSF11	152404	broad.mit.edu	37	3	118623538	118623538	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:118623538T>C	uc003ebw.2	-	6	1058	c.811A>G	c.(811-813)AAA>GAA	p.K271E	IGSF11_uc011biv.1_Missense_Mutation_p.K243E|IGSF11_uc003ebx.2_Missense_Mutation_p.K247E|IGSF11_uc003eby.2_Missense_Mutation_p.K270E|IGSF11_uc003ebz.2_Missense_Mutation_p.K246E|IGSF11_uc010hqs.2_Missense_Mutation_p.K270E	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	271	Cytoplasmic (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						TCTTTATTTTTGCTTCTCCAG	0.353			NA											225	78					0	0	0.00361	0	0
PLA1A	51365	broad.mit.edu	37	3	119336897	119336897	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:119336897G>T	uc003ecu.2	+	7	825	c.786G>T	c.(784-786)AGG>AGT	p.R262S	PLA1A_uc003ecv.2_Missense_Mutation_p.R246S|PLA1A_uc003ecw.2_RNA|PLA1A_uc011bjc.1_Missense_Mutation_p.R89S	NM_015900	NP_056984	Q53H76	PLA1A_HUMAN	phospholipase A1 member A precursor	262					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3						ATCACATGAGGGCTGTGCACC	0.468			NA											220	112					7.99439e-90	1.50988e-89	0.00361	1	0
GTF2E1	2960	broad.mit.edu	37	3	120500084	120500084	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:120500084G>T	uc003edz.3	+	5	1201	c.1087G>T	c.(1087-1089)GAT>TAT	p.D363Y		NM_005513	NP_005504	P29083	T2EA_HUMAN	general transcription factor IIE, polypeptide 1,	363					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.159)		TGAGTCAGATGATGATTCTCC	0.532			NA											73	56					4.98926e-31	8.38334e-31	0.00361	1	0
POLQ	10721	broad.mit.edu	37	3	121151258	121151258	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:121151258G>A	uc003eee.3	-	30	7795	c.7666C>T	c.(7666-7668)CAG>TAG	p.Q2556*	POLQ_uc003eed.2_Nonsense_Mutation_p.Q1728*	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	2556					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TTGACAATCTGAGCTACCTAA	0.398	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					24	17					0	0	0.002299	0	0
SLC15A2	6565	broad.mit.edu	37	3	121643199	121643199	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:121643199G>C	uc003eep.2	+	12	1157	c.1004G>C	c.(1003-1005)GGG>GCG	p.G335A	SLC15A2_uc011bjn.1_Missense_Mutation_p.G304A	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	335					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	ATGTTTCAGGGGTTTTTTGTG	0.368			NA											36	109					0	0	0.007835	0	0
CD86	942	broad.mit.edu	37	3	121822511	121822511	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:121822511G>T	uc003eet.2	+	3	333	c.217G>T	c.(217-219)GAG>TAG	p.E73*	CD86_uc011bjo.1_5'UTR|CD86_uc011bjp.1_Intron|CD86_uc003eeu.2_Nonsense_Mutation_p.E67*	NM_175862	NP_787058	P42081	CD86_HUMAN	CD86 antigen isoform 1	73	Ig-like V-type.|Extracellular (Potential).				interspecies interaction between organisms|positive regulation of cell proliferation|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of lymphotoxin A biosynthetic process|positive regulation of T-helper 2 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation		coreceptor activity|protein binding			pancreas(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.156)	Abatacept(DB01281)	CTTAGGCAAAGAGAAATTTGA	0.428	GBM(67;1379 1389 36064 39806)		NA											17	72					1.67942e-08	1.97446e-08	0.006122	1	0
CASR	846	broad.mit.edu	37	3	121976194	121976194	+	Missense_Mutation	SNP	C	C	A	rs104893694		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:121976194C>A	uc003eev.3	+	3	824	c.452C>A	c.(451-453)ACG>AAG	p.T151K	CASR_uc003eew.3_Missense_Mutation_p.T151K	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	151	Extracellular (Potential).		T -> M (in FIH; there is a shift in the dose-response curve so that the extracellular calcium concentration needed to produce half-maximal increase in total inositol phosphate in the cells is significantly lower than the one required for the wild-type receptor).		anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GGCGTCTCCACGGCAGTGGCA	0.542			NA											39	29					1.30998e-17	1.84928e-17	0.005524	1	0
KALRN	8997	broad.mit.edu	37	3	123987871	123987871	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:123987871G>T	uc003ehg.2	+	5	859	c.732G>T	c.(730-732)GAG>GAT	p.E244D	KALRN_uc010hrv.1_Missense_Mutation_p.E244D|KALRN_uc003ehf.1_Missense_Mutation_p.E244D|KALRN_uc011bjy.1_Missense_Mutation_p.E244D	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	244	Spectrin 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						CTGTGGAGGAGCTGGACCGGG	0.627			NA											15	10					4.14922e-12	5.25513e-12	0.004007	1	0
KALRN	8997	broad.mit.edu	37	3	124356145	124356145	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:124356145A>C	uc003ehg.2	+	37	5783	c.5656A>C	c.(5656-5658)AAG>CAG	p.K1886Q	KALRN_uc003ehi.2_Intron|KALRN_uc003ehk.2_Missense_Mutation_p.K189Q|KALRN_uc011bjz.1_5'UTR|KALRN_uc003ehj.2_Intron	NM_001024660	NP_001019831	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase isoform 1	1885					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(2)|ovary(2)|central_nervous_system(1)|skin(1)	6						GGTCAAAAACAAGCTGGTAAG	0.522			NA											60	48					0	0	0.00361	0	0
UMPS	7372	broad.mit.edu	37	3	124461062	124461062	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:124461062A>T	uc003ehl.3	+	5	1328	c.1222A>T	c.(1222-1224)ATG>TTG	p.M408L	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_Missense_Mutation_p.M230L|UMPS_uc011bkb.1_Missense_Mutation_p.M316L|UMPS_uc011bkc.1_Missense_Mutation_p.M230L|UMPS_uc003ehn.3_Missense_Mutation_p.M230L|UMPS_uc011bkd.1_Intron	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	408	OMPdecase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		CCGAGTAAGCATGAAACCAGA	0.408			NA											80	89					0	0	0.00361	0	0
MUC13	56667	broad.mit.edu	37	3	124646687	124646687	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:124646687G>T	uc003ehq.1	-	2	227	c.203C>A	c.(202-204)CCT>CAT	p.P68H		NM_033049	NP_149038	Q9H3R2	MUC13_HUMAN	mucin 13, epithelial transmembrane	68	Thr-rich.|Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane					0						GGGGGGAGCAGGTGAAGTAGC	0.453			NA											58	187					4.88506e-25	7.75037e-25	0.00361	1	0
HEG1	57493	broad.mit.edu	37	3	124746174	124746174	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:124746174A>T	uc003ehs.3	-	3	856	c.788T>A	c.(787-789)CTT>CAT	p.L263H	HEG1_uc011bke.1_Missense_Mutation_p.L263H	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	263	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						CAAAGCAGGAAGAAAGGACGG	0.562			NA											18	8					0	0	0.002299	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125844477	125844477	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:125844477C>A	uc003eim.1	-	15	1972	c.1782G>T	c.(1780-1782)GTG>GTT	p.V594V	ALDH1L1_uc010hse.1_RNA|ALDH1L1_uc011bki.1_Silent_p.V493V	NM_012190	NP_036322	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	594	Aldehyde dehydrogenase.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GCTTGATCACCACTGTGTTCC	0.572			NA											15	57					4.7546e-09	5.65871e-09	0.004007	1	0
RPN1	6184	broad.mit.edu	37	3	128345673	128345673	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:128345673C>G	uc003ekr.1	-	6	1115	c.1039G>C	c.(1039-1041)GAC>CAC	p.D347H	RPN1_uc011bkq.1_Missense_Mutation_p.D175H	NM_002950	NP_002941	P04843	RPN1_HUMAN	ribophorin I precursor	347	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(114;0.189)		GCATACTGGTCACCTGAAGGA	0.453			NA	T	EVI1	AML								13	40					0	0	0.00245	0	0
COL29A1	256076	broad.mit.edu	37	3	130188172	130188172	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:130188172G>T	uc010htj.1	+	38	7818	c.7324G>T	c.(7324-7326)GTG>TTG	p.V2442L	COL29A1_uc010hti.1_RNA|COL29A1_uc010htk.1_Missense_Mutation_p.V481L	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	2442	VWFA 10.|Nonhelical region.				axon guidance|cell adhesion	collagen					0						CTCCATATTTGTGTTTTCCTT	0.438			NA											16	32					6.72482e-11	8.32105e-11	0.003163	1	0
COL6A6	131873	broad.mit.edu	37	3	130284285	130284285	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:130284285C>T	uc010htl.2	+	3	1140	c.1109C>T	c.(1108-1110)GCC>GTC	p.A370V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	370	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						ATAGAGGGCGCCAGCGACACC	0.547			NA											43	85					0	0	0.009718	0	0
MRPL3	11222	broad.mit.edu	37	3	131181700	131181700	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:131181700G>A	uc003eoh.2	-	10	1078	c.914C>T	c.(913-915)CCT>CTT	p.P305L	MRPL3_uc011blo.1_Missense_Mutation_p.P200L|MRPL3_uc011blp.1_Missense_Mutation_p.P332L	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	305					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						CTTATATGCAGGCAGTTTAGA	0.348			NA											28	21					0	0	0.002445	0	0
MRPL3	11222	broad.mit.edu	37	3	131208896	131208896	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:131208896C>A	uc003eoh.2	-	5	661	c.497G>T	c.(496-498)CGG>CTG	p.R166L	MRPL3_uc011blo.1_Missense_Mutation_p.R61L|MRPL3_uc011blp.1_Missense_Mutation_p.R193L	NM_007208	NP_009139	P09001	RM03_HUMAN	mitochondrial ribosomal protein L3	166					translation	mitochondrial large ribosomal subunit	RNA binding|structural constituent of ribosome				0						TCCAAGTTCCCGGTAAAATTC	0.363			NA											15	15					8.60227e-14	1.12183e-13	0.004007	1	0
TF	7018	broad.mit.edu	37	3	133485178	133485178	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:133485178C>A	uc003epu.1	+	17	3115	c.1387C>A	c.(1387-1389)CTG>ATG	p.L463M	TF_uc011blt.1_Missense_Mutation_p.L336M|TF_uc003epw.1_Intron|TF_uc003epv.1_Missense_Mutation_p.L463M	NM_001063	NP_001054	P02787	TRFE_HUMAN	transferrin precursor	463	Transferrin-like 2.				cellular iron ion homeostasis|platelet activation|platelet degranulation|transferrin transport|transmembrane transport	apical plasma membrane|basal plasma membrane|coated pit|early endosome|endocytic vesicle|endosome membrane|extracellular region|late endosome|perinuclear region of cytoplasm|recycling endosome|stored secretory granule	ferric iron binding			ovary(1)|skin(1)	2					Aluminium(DB01370)|Bismuth(DB01402)|Iron Dextran(DB00893)	CTGGGACAATCTGAAAGGCAA	0.488			NA											65	139					7.82978e-24	1.22218e-23	0.00361	1	0
EPHB1	2047	broad.mit.edu	37	3	134967287	134967287	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:134967287A>C	uc003eqt.2	+	14	2846	c.2626A>C	c.(2626-2628)AAC>CAC	p.N876H	EPHB1_uc003equ.2_Missense_Mutation_p.N437H	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	876	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGAGATTGTCAACACCCTAGA	0.567			NA											7	30					0	0	0.001984	0	0
A4GNT	51146	broad.mit.edu	37	3	137843458	137843458	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:137843458C>A	uc003ers.2	-	3	873	c.671G>T	c.(670-672)GGC>GTC	p.G224V		NM_016161	NP_057245	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	224	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			central_nervous_system(1)	1						CAACTCAGGGCCTTGGTTGCC	0.468			NA											21	83					8.34094e-07	9.35694e-07	0.008871	1	0
PRR23B	389151	broad.mit.edu	37	3	138738889	138738889	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:138738889A>G	uc003esy.1	-	1	880	c.615T>C	c.(613-615)AGT>AGC	p.S205S		NM_001013650	NP_001013672	Q6ZRT6	PR23B_HUMAN	proline rich 23B	205	Pro-rich.									breast(1)	1						GTCTCTCTGAACTGGGGTTGG	0.627			NA											20	47					0	0	0.010504	0	0
COPB2	9276	broad.mit.edu	37	3	139087022	139087022	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:139087022C>T	uc003etf.3	-	13	1640	c.1510G>A	c.(1510-1512)GGA>AGA	p.G504R	COPB2_uc011bmv.1_Missense_Mutation_p.G475R|COPB2_uc010hui.2_Missense_Mutation_p.G475R	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	504					COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						TCAGTAACTCCCTCATGTGTT	0.383			NA											11	50					0	0	0.001855	0	0
COPB2	9276	broad.mit.edu	37	3	139098004	139098004	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:139098004C>T	uc003etf.3	-	4	370	c.240G>A	c.(238-240)CAG>CAA	p.Q80Q	COPB2_uc011bmv.1_Silent_p.Q51Q|COPB2_uc010hui.2_Silent_p.Q51Q|COPB2_uc011bmw.1_Silent_p.Q80Q	NM_004766	NP_004757	P35606	COPB2_HUMAN	coatomer protein complex, subunit beta 2 (beta	80	WD 2.				COPI coating of Golgi vesicle|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity			ovary(2)	2						ACACTCTAATCTGCATGTCAT	0.353			NA											10	19					0	0	0.006214	0	0
CLSTN2	64084	broad.mit.edu	37	3	140185544	140185544	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:140185544C>A	uc003etn.2	+	8	1505	c.1315C>A	c.(1315-1317)CCC>ACC	p.P439T	CLSTN2_uc003etm.2_Missense_Mutation_p.P439T	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	439	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CACCTTTCGCCCCGCGGAGTT	0.562	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			15	39					1.5739e-10	1.93387e-10	0.004007	1	0
CLSTN2	64084	broad.mit.edu	37	3	140251199	140251199	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:140251199A>T	uc003etn.2	+	9	1568	c.1378A>T	c.(1378-1380)AAT>TAT	p.N460Y	CLSTN2_uc003etm.2_Missense_Mutation_p.N460Y	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	460	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTATGTCATCAATGTGGAGTT	0.383	GBM(45;858 913 3709 36904 37282)		NA								HNSCC(16;0.037)			54	47					0	0	0.00361	0	0
RASA2	5922	broad.mit.edu	37	3	141272715	141272715	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:141272715G>T	uc003etz.1	+	6	544	c.544G>T	c.(544-546)GGG>TGG	p.G182W	RASA2_uc010huq.1_Missense_Mutation_p.G182W|RASA2_uc003eua.1_Missense_Mutation_p.G182W|RASA2_uc011bnc.1_5'UTR	NM_006506	NP_006497	Q15283	RASA2_HUMAN	RAS p21 protein activator 2	182	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	intracellular membrane-bounded organelle|intrinsic to internal side of plasma membrane|perinuclear region of cytoplasm	metal ion binding|Ras GTPase activator activity			ovary(2)|lung(2)|breast(1)|skin(1)	6						GGCATGCCATGGGTTGCCTCT	0.323			NA											27	76					7.16026e-08	8.3071e-08	0.002445	1	0
ATR	545	broad.mit.edu	37	3	142232433	142232433	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:142232433C>T	uc003eux.3	-	26	4673	c.4551G>A	c.(4549-4551)ATG>ATA	p.M1517I		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	1517					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						CATGCTTCATCATAATGCTAC	0.363			NA						Other_conserved_DNA_damage_response_genes					10	27					0	0	0.006214	0	0
ATR	545	broad.mit.edu	37	3	142281082	142281082	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:142281082C>T	uc003eux.3	-	4	1284	c.1162G>A	c.(1162-1164)GAT>AAT	p.D388N		NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	388					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						ACCTCTGCATCTACCTCAATT	0.313			NA						Other_conserved_DNA_damage_response_genes					6	31					0	0	0.001984	0	0
PLSCR4	57088	broad.mit.edu	37	3	145924363	145924363	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:145924363C>A	uc010huy.2	-	4	633	c.304G>T	c.(304-306)GGG>TGG	p.G102W	PLSCR4_uc010huz.2_Missense_Mutation_p.G102W|PLSCR4_uc003evt.3_Missense_Mutation_p.G102W|PLSCR4_uc010hva.2_Missense_Mutation_p.G102W|PLSCR4_uc003evu.3_Missense_Mutation_p.G87W	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	102	SH3-binding 3 (Potential).|Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						GGAGTTGGCCCTGGCATCCAT	0.448			NA											49	51					1.4374e-25	2.28989e-25	0.00361	1	0
PLSCR4	57088	broad.mit.edu	37	3	145924375	145924375	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:145924375T>A	uc010huy.2	-	4	621	c.292A>T	c.(292-294)ACA>TCA	p.T98S	PLSCR4_uc010huz.2_Missense_Mutation_p.T98S|PLSCR4_uc003evt.3_Missense_Mutation_p.T98S|PLSCR4_uc010hva.2_Missense_Mutation_p.T98S|PLSCR4_uc003evu.3_Missense_Mutation_p.T83S	NM_001128305	NP_001121777	Q9NRQ2	PLS4_HUMAN	phospholipid scramblase 4 isoform a	98	SH3-binding 3 (Potential).|Cytoplasmic (By similarity).				blood coagulation|phospholipid scrambling	integral to membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding				0						GGCATCCATGTTATTGGAACA	0.453			NA											29	67					0	0	0.002096	0	0
PLSCR5	389158	broad.mit.edu	37	3	146318153	146318153	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:146318153T>A	uc003ewb.2	-	2	1115	c.111A>T	c.(109-111)GCA>GCT	p.A37A	PLSCR5_uc010hvb.2_Silent_p.A37A|PLSCR5_uc010hvc.2_Silent_p.A37A	NM_001085420	NP_001078889	A0PG75	PLS5_HUMAN	phospholipid scramblase family, member 5	37											0						TCAGCTGCCATGCTTGGTTCC	0.502			NA											5	11					0	0	0.000602	0	0
ZIC4	84107	broad.mit.edu	37	3	147108855	147108855	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:147108855C>A	uc003ewd.1	-	4	1140	c.867G>T	c.(865-867)GGG>GGT	p.G289G	ZIC4_uc003ewc.1_Silent_p.G219G|ZIC4_uc011bno.1_Silent_p.G339G	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	289						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GCGGCGAGCGCCCGTGCACCT	0.662			NA											14	53					0.000308642	0.000326004	0.003163	1	0
ZIC1	7545	broad.mit.edu	37	3	147131139	147131139	+	Splice_Site	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:147131139A>C	uc003ewe.2	+	3	1866	c.1147_splice	c.e3-2	p.V383_splice		NM_003412	NP_003403	Q15915	ZIC1_HUMAN	zinc finger protein of the cerebellum 1						behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						TTATTCCTGCAGGTCCACGAA	0.632			NA											12	59					0	0	0.000978	0	0
COMMD2	51122	broad.mit.edu	37	3	149470067	149470067	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:149470067G>A	uc003exk.2	-	2	122	c.75C>T	c.(73-75)GCC>GCT	p.A25A		NM_016094	NP_057178	Q86X83	COMD2_HUMAN	COMM domain containing 2	25							protein binding				0			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCCAAACTCGGCGACCACTG	0.617			NA											77	54					0	0	0.00361	0	0
P2RY14	9934	broad.mit.edu	37	3	150931951	150931952	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:150931951_150931952TG>CT	uc003eyr.1	-	3	631_632	c.153_154CA>AG	c.(151-156)CCCAGC>CCAGGC	p.S52G	MED12L_uc011bnz.1_Intron|MED12L_uc003eyp.2_Intron|P2RY14_uc003eys.1_Missense_Mutation_p.S52G	NM_001081455	NP_001074924	Q15391	P2Y14_HUMAN	P2Y14 receptor	52	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			large_intestine(2)|ovary(1)|lung(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CTCTTAGAGCTGGGCACGTAAA	0.436			NA											43	38					0	0	0.004672	0	0
MED12L	116931	broad.mit.edu	37	3	151105894	151105894	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:151105894C>T	uc003eyp.2	+	35	5318	c.5280C>T	c.(5278-5280)ACC>ACT	p.T1760T	MED12L_uc011bnz.1_Silent_p.T1620T|MED12L_uc003eyy.1_Silent_p.T923T	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	1760					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGGGAAAAACCACAACAGATG	0.488			NA											16	13					0	0	0.004007	0	0
SLITRK3	22865	broad.mit.edu	37	3	164907028	164907028	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:164907028G>C	uc003fej.3	-	2	2035	c.1591C>G	c.(1591-1593)CGG>GGG	p.R531G	SLITRK3_uc003fek.2_Missense_Mutation_p.R531G	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	531	Extracellular (Potential).|LRR 12.					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						AGGTTGAGCCGGGCCAGGGAT	0.507			NA								HNSCC(40;0.11)			8	26					0	0	0.004482	0	0
WDR49	151790	broad.mit.edu	37	3	167319990	167319990	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:167319990C>A	uc003fev.1	-	3	483	c.177G>T	c.(175-177)TGG>TGT	p.W59C	WDR49_uc011bpd.1_Missense_Mutation_p.W112C|WDR49_uc003few.1_Missense_Mutation_p.W400C	NM_178824	NP_849146	Q8IV35	WDR49_HUMAN	WD repeat domain 49	59										large_intestine(1)|ovary(1)|skin(1)	3						CTGAGTGGCCCCAAAGGACAC	0.373			NA											11	39					1.58986e-06	1.77324e-06	0.008291	1	0
GOLIM4	27333	broad.mit.edu	37	3	167747580	167747580	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:167747580T>A	uc003ffe.2	-	10	1765	c.1421A>T	c.(1420-1422)CAG>CTG	p.Q474L	GOLIM4_uc011bpe.1_Missense_Mutation_p.Q474L|GOLIM4_uc011bpf.1_Missense_Mutation_p.Q446L|GOLIM4_uc011bpg.1_Missense_Mutation_p.Q446L	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	474	Glu-rich.|Gln-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						GAGCTGCTCCTGGTGCTGCGG	0.438			NA											28	37					0	0	0.009535	0	0
PRKCI	5584	broad.mit.edu	37	3	170009707	170009707	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:170009707A>T	uc003fgs.2	+	13	1507	c.1269A>T	c.(1267-1269)GAA>GAT	p.E423D	PRKCI_uc003fgt.2_5'UTR	NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	423	Protein kinase.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			TTGCTCCTGAAATTTTAAGAG	0.343			NA											19	19					0	0	0.010504	0	0
PLD1	5337	broad.mit.edu	37	3	171406666	171406666	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:171406666C>A	uc003fhs.2	-	14	1455	c.1339G>T	c.(1339-1341)GTG>TTG	p.V447L	PLD1_uc003fht.2_Missense_Mutation_p.V447L	NM_002662	NP_002653	Q13393	PLD1_HUMAN	phospholipase D1 isoform a	447					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			ovary(2)|lung(1)	3	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	TGTCTCATCACCTTGAGAGGG	0.438	NSCLC(149;2174 3517 34058)		NA											10	23					0.000673444	0.000705548	0.008291	1	0
NLGN1	22871	broad.mit.edu	37	3	173999053	173999053	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:173999053C>A	uc003fio.1	+	7	2855	c.2432C>A	c.(2431-2433)CCC>CAC	p.P811H	NLGN1_uc003fip.1_Missense_Mutation_p.P811H	NM_014932	NP_055747	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	828	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)|ovary(1)|pancreas(1)	7	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CTGCCCCATCCCCATCCCCAC	0.423			NA											22	13					1.50039e-11	1.88181e-11	0.001882	1	0
NAALADL2	254827	broad.mit.edu	37	3	175184802	175184802	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:175184802G>T	uc003fit.2	+	8	1450	c.1363G>T	c.(1363-1365)GCA>TCA	p.A455S	NAALADL2_uc003fiu.1_Missense_Mutation_p.A448S|NAALADL2_uc010hwy.1_Missense_Mutation_p.A229S|NAALADL2_uc010hwz.1_Missense_Mutation_p.A49S	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	455	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TCATCACACTGCACACAGTTA	0.388			NA											41	149					2.77807e-22	4.24726e-22	0.003214	1	0
TTC14	151613	broad.mit.edu	37	3	180324138	180324138	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:180324138G>A	uc003fkk.2	+	8	1159	c.1027G>A	c.(1027-1029)GCT>ACT	p.A343T	TTC14_uc003fkl.2_Missense_Mutation_p.A343T|TTC14_uc003fkm.2_Missense_Mutation_p.A343T	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	343	TPR 3.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAACGTGGAAGCTTTGGTAGC	0.368			NA											19	48					0	0	0.007413	0	0
SOX2	6657	broad.mit.edu	37	3	181430578	181430578	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:181430578G>C	uc003fkx.2	+	1	857	c.430G>C	c.(430-432)GGG>CGG	p.G144R	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	144					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			GAGCGGGGTCGGGGTGGGCGC	0.677			NA	A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						7	14					0	0	0.00308	0	0
MCF2L2	23101	broad.mit.edu	37	3	183014772	183014772	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:183014772C>T	uc003fli.1	-	12	1579	c.1489G>A	c.(1489-1491)GAT>AAT	p.D497N	MCF2L2_uc003flj.1_Missense_Mutation_p.D497N|MCF2L2_uc011bqr.1_Intron|uc003fln.1_RNA|uc003flo.2_5'Flank	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	497					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCTTTGCATCGAGGGTGAGC	0.512			NA											11	48					0	0	0.000978	0	0
ABCC5	10057	broad.mit.edu	37	3	183696421	183696421	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:183696421C>A	uc003fmg.2	-	9	1331	c.1166G>T	c.(1165-1167)CGT>CTT	p.R389L	ABCC5_uc011bqt.1_5'UTR|ABCC5_uc010hxl.2_Missense_Mutation_p.R389L	NM_005688	NP_005679	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C, member 5	389	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CAATATCCGACGCTCCTCCTC	0.473			NA											12	35					6.40141e-05	6.88944e-05	0.000978	1	0
AP2M1	1173	broad.mit.edu	37	3	183896818	183896818	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:183896818A>G	uc011bqx.1	+	3	405	c.248A>G	c.(247-249)TAT>TGT	p.Y83C	AP2M1_uc003fmw.2_Missense_Mutation_p.Y83C|AP2M1_uc003fmx.2_Missense_Mutation_p.Y83C|AP2M1_uc003fmy.2_Missense_Mutation_p.Y83C|AP2M1_uc011bqy.1_5'Flank|AP2M1_uc011bqz.1_5'Flank	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit	83					axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAATTCCTCTATAAGATGTGT	0.483			NA											44	94					0	0	0.002852	0	0
AP2M1	1173	broad.mit.edu	37	3	183899836	183899836	+	Splice_Site	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:183899836G>A	uc011bqx.1	+	9	1120	c.963_splice	c.e9+1	p.E321_splice	AP2M1_uc003fmw.2_Splice_Site_p.E319_splice|AP2M1_uc003fmx.2_Splice_Site_p.E249_splice|AP2M1_uc003fmy.2_Splice_Site_p.E319_splice|AP2M1_uc011bqy.1_Splice_Site_p.E191_splice|AP2M1_uc011bqz.1_Splice_Site_p.E137_splice	NM_004068	NP_004059	Q96CW1	AP2M1_HUMAN	adaptor-related protein complex 2, mu 1 subunit						axon guidance|cellular membrane organization|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|vesicle-mediated transport|viral reproduction	clathrin adaptor complex|clathrin coat of coated pit|cytosol|endocytic vesicle membrane|peroxisomal membrane	lipid binding|protein binding|transporter activity				0	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.92e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GAAGATCGAGGTGAGGACAGG	0.532			NA											5	23					0	0	0.000602	0	0
EIF4G1	1981	broad.mit.edu	37	3	184045040	184045040	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:184045040A>T	uc003fnp.2	+	24	3663	c.3465A>T	c.(3463-3465)GGA>GGT	p.G1155G	EIF4G1_uc003fnt.2_Silent_p.G866G|EIF4G1_uc003fnq.2_Silent_p.G1068G|EIF4G1_uc003fnr.2_Silent_p.G991G|EIF4G1_uc010hxx.2_Silent_p.G1162G|EIF4G1_uc003fns.2_Silent_p.G1115G|EIF4G1_uc010hxy.2_Silent_p.G1162G|EIF4G1_uc003fnv.3_Silent_p.G1156G|EIF4G1_uc003fnu.3_Silent_p.G1155G|EIF4G1_uc003fnw.2_Silent_p.G1162G|EIF4G1_uc003fnx.2_Silent_p.G960G|EIF4G1_uc003fny.3_Silent_p.G959G|EIF4G1_uc003foa.2_5'Flank	NM_198241	NP_937884	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4	1155					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			lung(2)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGAAAGCTGGAGACCGAGGAG	0.577			NA											21	48					0	0	0.008871	0	0
C3orf70	285382	broad.mit.edu	37	3	184801010	184801010	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:184801010G>T	uc003fpd.2	-	2	729	c.538C>A	c.(538-540)CAC>AAC	p.H180N		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	180											0						GAAGAGCAGTGATCTATTTTT	0.498			NA											35	33					2.20474e-14	2.90857e-14	0.003755	1	0
CRYGS	1427	broad.mit.edu	37	3	186257313	186257313	+	Missense_Mutation	SNP	G	G	T	rs148842396		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:186257313G>T	uc003fqe.2	-	2	147	c.95C>A	c.(94-96)ACA>AAA	p.T32K	CRYGS_uc003fqf.2_Missense_Mutation_p.T32K	NM_017541	NP_060011	P22914	CRBS_HUMAN	crystallin, gamma S	32	Beta/gamma crystallin 'Greek key' 1.			T -> M (in Ref. 2; AA sequence).			structural constituent of eye lens				0	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		ACTTAGGTATGTGTGGAAATC	0.453			NA											31	74					3.99451e-17	5.57789e-17	0.009535	1	0
KNG1	3827	broad.mit.edu	37	3	186457126	186457126	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:186457126G>A	uc011bsa.1	+	9	1260	c.1048G>A	c.(1048-1050)GAT>AAT	p.D350N	KNG1_uc003fqr.2_Missense_Mutation_p.D350N	NM_001102416	NP_001095886	P01042	KNG1_HUMAN	kininogen 1 isoform 1	350	Cystatin 3.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			skin(1)	1	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GCAAAGCCTAGATTGCAACGC	0.383			NA											14	34					0	0	0.003163	0	0
RTP2	344892	broad.mit.edu	37	3	187416361	187416361	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:187416361C>A	uc003fro.1	-	2	1032	c.603G>T	c.(601-603)TGG>TGT	p.W201C		NM_001004312	NP_001004312	Q5QGT7	RTP2_HUMAN	receptor transporting protein 2	201	Helical; (Potential).				protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding				0	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		AGAAGAGGCACCAGCGAAGAG	0.567			NA											29	21					3.80469e-20	5.61701e-20	0.009535	1	0
TMEM207	131920	broad.mit.edu	37	3	190147424	190147424	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:190147424C>G	uc003fsj.2	-	5	468	c.401G>C	c.(400-402)GGC>GCC	p.G134A		NM_207316	NP_997199	Q6UWW9	TM207_HUMAN	transmembrane protein 207 precursor	134						integral to membrane					0	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.0176)		AGGTGGGGAGCCTAAAGGGCC	0.408			NA											36	18					0	0	0.004878	0	0
OSTN	344901	broad.mit.edu	37	3	190936625	190936625	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:190936625T>A	uc011bsn.1	+	2	192	c.192T>A	c.(190-192)CTT>CTA	p.L64L		NM_198184	NP_937827	P61366	OSTN_HUMAN	osteocrin precursor	64					cell differentiation|multicellular organismal development|ossification		hormone activity			pancreas(1)|skin(1)	2	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		AACTCTTGCTTCTTGATGAAT	0.458			NA											20	42					0	0	0.010504	0	0
TNK2	10188	broad.mit.edu	37	3	195594441	195594441	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:195594441G>A	uc003fvu.1	-	12	3226	c.2683C>T	c.(2683-2685)CCC>TCC	p.P895S	TNK2_uc003fvq.1_Missense_Mutation_p.P302S|TNK2_uc003fvr.1_Missense_Mutation_p.P420S|TNK2_uc003fvs.1_Missense_Mutation_p.P927S|TNK2_uc003fvt.1_Missense_Mutation_p.P973S|TNK2_uc010hzw.1_RNA	NM_005781	NP_005772	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2 isoform 1	895	Pro-rich.			Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			ovary(3)|central_nervous_system(3)|lung(2)|stomach(1)|skin(1)	10	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	ctgggtgggggcagcagcaga	0.448			NA											7	20					0	0	0.001984	0	0
C3orf34	84984	broad.mit.edu	37	3	196434644	196434644	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:196434644C>A	uc011btw.1	-	3	664	c.282G>T	c.(280-282)ATG>ATT	p.M94I		NM_032898	NP_116287	Q96LK0	CEP19_HUMAN	hypothetical protein LOC84984	90						centriole|spindle pole					0	all_cancers(143;1.48e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;1.08e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00301)		GAATTTGTTCCATTGTTTCTG	0.433			NA											84	69					6.16549e-39	1.08302e-38	0.00361	1	0
PAK2	5062	broad.mit.edu	37	3	196547287	196547287	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:196547287G>C	uc003fwy.3	+	13	1521	c.1199G>C	c.(1198-1200)CGC>CCC	p.R400P		NM_002577	NP_002568	Q13177	PAK2_HUMAN	p21-activated kinase 2	400	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of apoptosis|regulation of defense response to virus by virus|regulation of growth|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|nucleus|perinuclear region of cytoplasm|plasma membrane	ATP binding|identical protein binding|protein kinase binding|protein serine/threonine kinase activity|protein tyrosine kinase activator activity			ovary(1)|lung(1)	2	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;1.07e-23)|all cancers(36;6.38e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.5e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00405)		CAGAGCAAACGCAGTACCATG	0.483			NA											51	42					0	0	0.00361	0	0
IQCG	84223	broad.mit.edu	37	3	197618359	197618359	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:197618359C>T	uc003fyo.2	-	10	1301	c.1155G>A	c.(1153-1155)AAG>AAA	p.K385K	IQCG_uc003fyn.2_Silent_p.K287K|IQCG_uc003fyp.2_Silent_p.K385K|IQCG_uc003fym.2_Silent_p.K86K	NM_001134435	NP_001127907	Q9H095	IQCG_HUMAN	IQ motif containing G	385											0	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;7.19e-24)|all cancers(36;3.34e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.149)		GTTTTACCTTCTTCTTGCTCC	0.368			NA											18	25					0	0	0.001882	0	0
ZNF595	152687	broad.mit.edu	37	4	59446	59446	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:59446C>A	uc003fzv.1	+	2	283	c.127C>A	c.(127-129)CTG>ATG	p.L43M	ZNF595_uc003fzu.1_RNA|ZNF718_uc003fzt.3_Missense_Mutation_p.L43M|ZNF595_uc010iay.1_RNA|ZNF595_uc011bus.1_Translation_Start_Site|ZNF595_uc011but.1_Intron	NM_182524	NP_872330	Q7Z3I0	Q7Z3I0_HUMAN	zinc finger protein 595	43					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		CCTGGTCTCCCTGGGTGAGGA	0.428			NA											77	208					1.58458e-29	2.62828e-29	0.00361	1	0
ZNF141	7700	broad.mit.edu	37	4	367427	367427	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:367427G>T	uc003gaa.2	+	5	1379	c.1201G>T	c.(1201-1203)GGC>TGC	p.G401C	ZNF141_uc003gab.2_Intron	NM_003441	NP_003432	Q15928	ZN141_HUMAN	zinc finger protein 141	401	C2H2-type 9.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding				0						TGAAGAATGTGGCAAAGCCTT	0.393			NA											17	60					3.45872e-05	3.74953e-05	0.004007	1	0
GAK	2580	broad.mit.edu	37	4	905555	905555	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:905555C>A	uc003gbm.3	-	4	487	c.288G>T	c.(286-288)CCG>CCT	p.P96P	GAK_uc003gbn.3_Intron|GAK_uc010ibk.1_Intron|GAK_uc003gbo.2_RNA|GAK_uc003gbl.3_5'UTR	NM_005255	NP_005246	O14976	GAK_HUMAN	cyclin G associated kinase	96	Protein kinase.				cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity			lung(2)|central_nervous_system(1)|skin(1)	4				Colorectal(103;0.219)		GGACAATGTTCGGGTGGCCGG	0.448			NA											62	35					7.05995e-25	1.11826e-24	0.00361	1	0
RNF212	285498	broad.mit.edu	37	4	1079701	1079701	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:1079701C>G	uc003gcj.2	-	5	675	c.345G>C	c.(343-345)CAG>CAC	p.Q115H	RNF212_uc003gci.2_Missense_Mutation_p.Q115H|RNF212_uc010ibp.2_RNA|RNF212_uc010ibq.2_Missense_Mutation_p.Q115H	NM_001131034	NP_001124506	Q495C1	RN212_HUMAN	ring finger protein 212 isoform a	115	Potential.						zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (64;0.151)		GTTGTTCTATCTGCAGCACTG	0.498			NA											36	100					0	0	0.005524	0	0
SH3BP2	6452	broad.mit.edu	37	4	2831327	2831327	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:2831327G>T	uc003gfi.3	+	8	814	c.694G>T	c.(694-696)GGT>TGT	p.G232C	SH3BP2_uc011bvp.1_Missense_Mutation_p.G260C|SH3BP2_uc003gfj.3_Missense_Mutation_p.G289C|SH3BP2_uc003gfk.3_Missense_Mutation_p.G232C|SH3BP2_uc003gfl.3_Missense_Mutation_p.G165C|SH3BP2_uc003gfm.3_Missense_Mutation_p.G207C	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	232					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CAAGGGCCCCGGTCCCCTACT	0.687			NA							Cherubism				12	56					6.40141e-05	6.88944e-05	0.000978	1	0
HTT	3064	broad.mit.edu	37	4	3129315	3129315	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:3129315C>T	uc011bvq.1	+	13	1878	c.1733C>T	c.(1732-1734)TCA>TTA	p.S578L		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	576					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GTTACCCCTTCAGACAGTTCT	0.418			NA											8	68					0	0	0.00308	0	0
DOK7	285489	broad.mit.edu	37	4	3478232	3478232	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:3478232C>T	uc003ghd.2	+	4	565	c.495C>T	c.(493-495)AGC>AGT	p.S165S	DOK7_uc003ghe.2_Missense_Mutation_p.A31V	NM_173660	NP_775931	Q18PE1	DOK7_HUMAN	downstream of tyrosine kinase 7 isoform 1	165	IRS-type PTB.				positive regulation of protein tyrosine kinase activity	cell junction|synapse	insulin receptor binding|protein kinase binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCGTGCCAAGCGGATTCATCT	0.627			NA											25	59					0	0	0.002096	0	0
WFS1	7466	broad.mit.edu	37	4	6303877	6303877	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:6303877C>T	uc003giy.2	+	8	2521	c.2355C>T	c.(2353-2355)AGC>AGT	p.S785S	WFS1_uc003gix.2_Silent_p.S785S|WFS1_uc003giz.2_Silent_p.S603S	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	785					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		CATTCAGCAGCGGCGCTGACG	0.627			NA											11	26					0	0	0.003163	0	0
SH3TC1	54436	broad.mit.edu	37	4	8229720	8229720	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:8229720C>T	uc003gkv.3	+	12	2400	c.2299C>T	c.(2299-2301)CAC>TAC	p.H767Y	SH3TC1_uc003gkw.3_Missense_Mutation_p.H691Y|SH3TC1_uc003gkx.3_RNA|SH3TC1_uc003gky.2_5'Flank	NM_018986	NP_061859	Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	767							binding			large_intestine(2)|pancreas(1)	3						CCAAACTTCCCACTACCTCAG	0.692	NSCLC(145;2298 2623 35616 37297)		NA											23	12					0	0	0.00278	0	0
LOC650293	650293	broad.mit.edu	37	4	8951509	8951509	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:8951509C>A	uc011bwm.1	+	1	33	c.33C>A	c.(31-33)CTC>CTA	p.L11L		NM_001040071	NP_001035160	Q8NGT4	Q8NGT4_HUMAN	seven transmembrane helix receptor	11						integral to membrane	olfactory receptor activity				0						GGAACCTCCTCAGTATCCTGG	0.592			NA											4	11					0.000602214	0.000632636	0.000602	1	0
DRD5	1816	broad.mit.edu	37	4	9783861	9783861	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:9783861C>A	uc003gmb.3	+	1	604	c.208C>A	c.(208-210)CAC>AAC	p.H70N		NM_000798	NP_000789	P21918	DRD5_HUMAN	dopamine receptor D5	70	Cytoplasmic (Potential).				activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				skin(1)	1					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GCGGAGCCGCCACCTGCGCGC	0.647			NA											30	18					1.36615e-20	2.03868e-20	0.002836	1	0
NKX3-2	579	broad.mit.edu	37	4	13544065	13544065	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:13544065C>A	uc003gmx.2	-	2	630	c.554G>T	c.(553-555)GGC>GTC	p.G185V		NM_001189	NP_001180	P78367	NKX32_HUMAN	NK3 homeobox 2	185	Poly-Gly.				negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						cccgctgccgcccccgccgcc	0.463			NA											11	4					4.68919e-08	5.45661e-08	0.008291	1	0
BOD1L	259282	broad.mit.edu	37	4	13602333	13602333	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:13602333C>A	uc003gmz.1	-	10	6308	c.6191G>T	c.(6190-6192)GGT>GTT	p.G2064V	BOD1L_uc010idr.1_Missense_Mutation_p.G1401V	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2064							DNA binding			ovary(5)|breast(1)	6						TTGATTTTTACCCCCTGCTAA	0.433			NA											10	52					1.58986e-06	1.77324e-06	0.008291	1	0
LAP3	51056	broad.mit.edu	37	4	17584016	17584016	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:17584016G>A	uc003gph.1	+	4	541	c.379G>A	c.(379-381)GCG>ACG	p.A127T	LAP3_uc010ieg.2_Intron	NM_015907	NP_056991	P28838	AMPL_HUMAN	leucine aminopeptidase 3	127					proteolysis	nucleus	aminopeptidase activity|magnesium ion binding|manganese ion binding|metalloexopeptidase activity|zinc ion binding				0						TGCTGTTGCAGGTTATTTCAC	0.463			NA											4	12					0	0	0.009096	0	0
GBA3	57733	broad.mit.edu	37	4	22737615	22737615	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:22737615G>A	uc003gqp.3	+	2	161	c.70G>A	c.(70-72)GCA>ACA	p.A24T	GBA3_uc010iep.2_Missense_Mutation_p.A24T|GBA3_uc011bxo.1_Missense_Mutation_p.A25T	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	24					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						AGGCTGGGATGCAGATGGAAA	0.438			NA											15	32					0	0	0.004007	0	0
GBA3	57733	broad.mit.edu	37	4	22749119	22749119	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:22749119A>C	uc003gqp.3	+	3	578	c.487A>C	c.(487-489)ATA>CTA	p.I163L	GBA3_uc010iep.2_Intron|GBA3_uc011bxo.1_Missense_Mutation_p.I164L	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	163					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						GTGGATCACCATAAATGAAGC	0.438			NA											62	40					0	0	0.00361	0	0
TBC1D19	55296	broad.mit.edu	37	4	26668003	26668003	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:26668003G>T	uc003gsf.3	+	9	910	c.640G>T	c.(640-642)GAT>TAT	p.D214Y	TBC1D19_uc010iew.2_Missense_Mutation_p.D214Y|TBC1D19_uc011bxu.1_Missense_Mutation_p.D149Y	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	214						intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				ACTGGGTATAGATGATTCTAC	0.343			NA											15	67					4.75885e-15	6.3914e-15	0.00499	1	0
PGM2	55276	broad.mit.edu	37	4	37857304	37857304	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:37857304A>T	uc011byb.1	+	13	1751	c.1678A>T	c.(1678-1680)AGT>TGT	p.S560C	PGM2_uc011byc.1_Missense_Mutation_p.S400C	NM_018290	NP_060760	Q96G03	PGM2_HUMAN	phosphoglucomutase 2	560					glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity|phosphopentomutase activity			ovary(1)	1						CATGCGCACCAGTGGGACAGA	0.488			NA											10	39					0	0	0.008291	0	0
TLR1	7096	broad.mit.edu	37	4	38798645	38798645	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:38798645T>A	uc003gtl.2	-	4	2082	c.1808A>T	c.(1807-1809)TAC>TTC	p.Y603F		NM_003263	NP_003254	Q15399	TLR1_HUMAN	toll-like receptor 1 precursor	603	Cytoplasmic (Potential).				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			lung(2)|skin(2)|prostate(1)	5						CAGATCCAAGTAGCTGCAGAG	0.527	GBM(5;216 373 40795 46382)		NA											67	52					0	0	0.00361	0	0
RFC1	5981	broad.mit.edu	37	4	39343997	39343997	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:39343997C>G	uc003gty.1	-	4	433	c.299G>C	c.(298-300)CGG>CCG	p.R100P	RFC1_uc003gtx.1_Missense_Mutation_p.R100P|RFC1_uc003gtz.1_5'UTR	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	100					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						AGGATCCTGCCGTGAAATTTT	0.398	Colon(109;59 1555 12203 17579 39824)|Esophageal Squamous(18;360 542 16186 28570 51157)		NA											19	38					0	0	0.006122	0	0
RHOH	399	broad.mit.edu	37	4	40245027	40245027	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:40245027C>A	uc003guz.2	+	3	745	c.21C>A	c.(19-21)TGC>TGA	p.C7*		NM_004310	NP_004301	Q15669	RHOH_HUMAN	ras homolog gene family, member H precursor	7					negative regulation of I-kappaB kinase/NF-kappaB cascade|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|T cell differentiation	cytosol|mitochondrion|plasma membrane	GTP binding|GTPase inhibitor activity|kinase inhibitor activity|Rho GTPase binding			ovary(1)|lung(1)	2						CCATCAAGTGCGTGTTGGTGG	0.577			NA											30	30					2.70662e-09	3.23523e-09	0.009535	1	0
KCTD8	386617	broad.mit.edu	37	4	44450425	44450425	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:44450425G>T	uc003gwu.2	-	1	400	c.116C>A	c.(115-117)CCC>CAC	p.P39H		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	39						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						GAAGGGCGAGGGTGCGCAggg	0.512			NA								HNSCC(17;0.042)			15	5					4.75885e-15	6.3914e-15	0.00499	1	0
GNPDA2	132789	broad.mit.edu	37	4	44720409	44720409	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:44720409C>A	uc003gwy.2	-	3	300	c.143G>T	c.(142-144)TGC>TTC	p.C48F	GNPDA2_uc010iga.2_Intron|GNPDA2_uc011bzb.1_5'UTR|GNPDA2_uc003gwz.1_Missense_Mutation_p.C48F	NM_138335	NP_612208	Q8TDQ7	GNPI2_HUMAN	glucosamine-6-phosphate deaminase 2	48					N-acetylglucosamine metabolic process	cytoplasm	glucosamine-6-phosphate deaminase activity|hydrolase activity			ovary(1)	1						TTTTTTATAGCATCCTAAAGG	0.244	Colon(54;743 1010 7604 16453 19544)		NA											7	19					1.06961e-07	1.23722e-07	0.00308	1	0
GABRA2	2555	broad.mit.edu	37	4	46252441	46252441	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:46252441C>A	uc003gxc.3	-	9	1913	c.1240G>T	c.(1240-1242)GTT>TTT	p.V414F	GABRA2_uc010igc.2_Missense_Mutation_p.V414F|GABRA2_uc011bzc.1_Missense_Mutation_p.V419F	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	414	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATTTTGCTAACACTGTTGAAA	0.393			NA											56	166					2.76378e-25	4.39208e-25	0.00361	1	0
GABRA2	2555	broad.mit.edu	37	4	46334653	46334653	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:46334653G>T	uc003gxc.3	-	3	907	c.234C>A	c.(232-234)GGC>GGA	p.G78G	GABRA2_uc010igc.2_Silent_p.G78G|GABRA2_uc011bzc.1_Intron|GABRA2_uc003gxe.2_Silent_p.G78G	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	78	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CTGAGACAGGGCCAAAACTGG	0.333			NA											12	51					2.61681e-11	3.26933e-11	0.00245	1	0
GABRA4	2557	broad.mit.edu	37	4	46930439	46930439	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:46930439C>A	uc003gxg.2	-	9	1607	c.1468G>T	c.(1468-1470)GTT>TTT	p.V490F		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	490	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATGGTATTAACTGTGGTCTTT	0.473	Ovarian(6;283 369 8234 12290 33402)		NA											30	70					7.01153e-11	8.67027e-11	0.007291	1	0
GABRA4	2557	broad.mit.edu	37	4	46930643	46930643	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:46930643T>C	uc003gxg.2	-	9	1403	c.1264A>G	c.(1264-1266)AAA>GAA	p.K422E		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	422	Cytoplasmic (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GGTGTGCCTTTAGAAGATTCT	0.448	Ovarian(6;283 369 8234 12290 33402)		NA											25	76					0	0	0.004656	0	0
ATP10D	57205	broad.mit.edu	37	4	47517556	47517556	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:47517556C>A	uc003gxk.1	+	3	518	c.354C>A	c.(352-354)TTC>TTA	p.F118L	ATP10D_uc003gxj.3_Missense_Mutation_p.F118L	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	118	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						TAGAAGCCTTCCAAAAGGAAA	0.418			NA											23	73					1.64293e-13	2.13394e-13	0.00333	1	0
ATP10D	57205	broad.mit.edu	37	4	47537548	47537548	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:47537548G>T	uc003gxk.1	+	6	963	c.799G>T	c.(799-801)GTG>TTG	p.V267L	ATP10D_uc003gxl.1_5'Flank|ATP10D_uc003gxj.3_Missense_Mutation_p.V267L	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	267	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						CAAAGAACGCGTGGGTCTCAG	0.378			NA											13	48					0.00316338	0.0032664	0.003163	1	0
CORIN	10699	broad.mit.edu	37	4	47765523	47765523	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:47765523T>C	uc003gxm.2	-	4	583	c.490A>G	c.(490-492)AGA>GGA	p.R164G	CORIN_uc011bzf.1_Missense_Mutation_p.R25G|CORIN_uc011bzg.1_Missense_Mutation_p.R97G|CORIN_uc011bzh.1_Missense_Mutation_p.R164G|CORIN_uc011bzi.1_Missense_Mutation_p.R164G|CORIN_uc003gxn.3_Missense_Mutation_p.R164G	NM_006587	NP_006578	Q9Y5Q5	CORIN_HUMAN	corin	164	Extracellular (Potential).|FZ 1.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			ovary(1)|central_nervous_system(1)	2						TCCATGTTTCTGACAACTGAG	0.493			NA											26	82					0	0	0.00632	0	0
FRYL	285527	broad.mit.edu	37	4	48524980	48524980	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:48524980C>T	uc003gyh.1	-	54	8064	c.7459G>A	c.(7459-7461)GAT>AAT	p.D2487N	FRYL_uc003gyf.1_5'Flank|FRYL_uc003gyg.1_Missense_Mutation_p.D1183N|FRYL_uc003gyi.1_Missense_Mutation_p.D1375N|FRYL_uc003gyj.1_Missense_Mutation_p.D782N	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	2487					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						GAGGACTCATCTGTATCCTCC	0.498			NA											93	74					0	0	0.00361	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52777283	52777283	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:52777283G>T	uc003gze.2	+	9	796	c.663G>T	c.(661-663)TTG>TTT	p.L221F	DCUN1D4_uc003gzf.2_Intron|DCUN1D4_uc011bzn.1_Missense_Mutation_p.L161F|DCUN1D4_uc003gzg.2_RNA|DCUN1D4_uc003gzh.2_Intron|DCUN1D4_uc011bzo.1_Missense_Mutation_p.L265F	NM_001040402	NP_001035492	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain	221	DCUN1.									ovary(2)	2			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			AGTGCATGTTGGGACTGTTAT	0.393			NA											20	44					1.37657e-19	2.0123e-19	0.001882	1	0
SCFD2	152579	broad.mit.edu	37	4	54231379	54231379	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:54231379G>A	uc003gzu.2	-	1	864	c.730C>T	c.(730-732)CAG>TAG	p.Q244*	SCFD2_uc010igm.2_Nonsense_Mutation_p.Q244*	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	244					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GCGATGACCTGACTTAAGGAA	0.517			NA											39	47					0	0	0.009718	0	0
LPHN3	23284	broad.mit.edu	37	4	62812687	62812687	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:62812687G>C	uc010ihh.2	+	13	2444	c.2271G>C	c.(2269-2271)ACG>ACC	p.T757T	LPHN3_uc003hcq.3_Silent_p.T757T|LPHN3_uc003hct.2_Silent_p.T150T	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	744	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						ATTTATCCACGGAGAATGCCA	0.393			NA											52	103					0	0	0.00361	0	0
LPHN3	23284	broad.mit.edu	37	4	62903488	62903488	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:62903488T>A	uc010ihh.2	+	21	3600	c.3427T>A	c.(3427-3429)TGT>AGT	p.C1143S	LPHN3_uc003hcq.3_Missense_Mutation_p.C1143S|LPHN3_uc003hct.2_Missense_Mutation_p.C527S	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1121	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						AACACATTGCTGTAGTGGCAA	0.413			NA											29	25					0	0	0.007291	0	0
LPHN3	23284	broad.mit.edu	37	4	62935844	62935844	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:62935844G>C	uc010ihh.2	+	23	3801	c.3628G>C	c.(3628-3630)GCC>CCC	p.A1210P	LPHN3_uc003hcq.3_Missense_Mutation_p.C1227S|LPHN3_uc003hct.2_Missense_Mutation_p.A594P	NM_015236	NP_056051	Q9HAR2	LPHN3_HUMAN	latrophilin 3 precursor	1188	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			lung(15)|ovary(1)|central_nervous_system(1)|pancreas(1)	18						TCTGAACAATGCCAGGGATAC	0.413			NA											17	24					0	0	0.010504	0	0
EPHA5	2044	broad.mit.edu	37	4	66467728	66467728	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:66467728C>A	uc003hcy.2	-	3	734	c.541G>T	c.(541-543)GAA>TAA	p.E181*	EPHA5_uc003hcx.2_Nonsense_Mutation_p.E112*|EPHA5_uc003hcz.2_Nonsense_Mutation_p.E181*|EPHA5_uc011cah.1_Nonsense_Mutation_p.E181*|EPHA5_uc011cai.1_Nonsense_Mutation_p.E181*|EPHA5_uc003hda.2_Nonsense_Mutation_p.E181*	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	181	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTAAAGCTTTCATCGGCAGCA	0.363			NA								TSP Lung(17;0.13)			17	46					5.01169e-05	5.42396e-05	0.00499	1	0
STAP1	26228	broad.mit.edu	37	4	68436841	68436841	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:68436841C>A	uc003hde.3	+	2	242	c.160C>A	c.(160-162)CTT>ATT	p.L54I	STAP1_uc003hdf.2_Missense_Mutation_p.L54I	NM_012108	NP_036240	Q9ULZ2	STAP1_HUMAN	signal transducing adaptor family member 1	54	PH.				cellular membrane fusion|intracellular protein transport	cytoplasm					0						AGGAACTACTCTTTTCTTTTA	0.308			NA											37	60					1.00776e-21	1.52623e-21	0.00361	1	0
GNRHR	2798	broad.mit.edu	37	4	68610368	68610368	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:68610368G>T	uc003hdn.2	-	2	2411	c.660C>A	c.(658-660)TTC>TTA	p.F220L	LOC550112_uc003hdl.3_Intron|GNRHR_uc003hdm.2_Missense_Mutation_p.H178N	NM_000406	NP_000397	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor isoform	220	Helical; Name=5; (Potential).				multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			ovary(1)	1					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GAGGGATGATGAAGAGGCAGC	0.428			NA											24	35					2.52088e-20	3.7302e-20	0.00278	1	0
TMPRSS11B	132724	broad.mit.edu	37	4	69100207	69100207	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:69100207G>T	uc003hdw.3	-	5	579	c.443C>A	c.(442-444)GCA>GAA	p.A148E		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	148	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						AGCAGGAACTGCATTCCAGGA	0.328			NA											9	26					1.58986e-06	1.77324e-06	0.008291	1	0
TMPRSS11B	132724	broad.mit.edu	37	4	69101916	69101916	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:69101916C>T	uc003hdw.3	-	3	329	c.193G>A	c.(193-195)GCA>ACA	p.A65T		NM_182502	NP_872308	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	65	SEA.|Extracellular (Potential).				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			ovary(1)	1						TGTGAAGCTGCGTTTTCACAA	0.279			NA											4	9					0	0	0.009096	0	0
UGT2B28	54490	broad.mit.edu	37	4	70155468	70155468	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:70155468T>G	uc003hej.2	+	4	1090	c.1088T>G	c.(1087-1089)CTA>CGA	p.L363R	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	363					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AATGACCTTCTAGGTAACACT	0.353			NA											22	42					0	0	0.002299	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156323	70156323	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:70156323C>G	uc003hej.2	+	5	1106	c.1104C>G	c.(1102-1104)ACC>ACG	p.T368T	UGT2B28_uc010ihr.2_Intron	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	368					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	TTCCAAAAACCAGAGCTTTTA	0.383			NA											25	44					0	0	0.008361	0	0
MUC7	4589	broad.mit.edu	37	4	71347452	71347452	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:71347452C>A	uc011cat.1	+	4	1279	c.991C>A	c.(991-993)CAC>AAC	p.H331N	MUC7_uc011cau.1_Missense_Mutation_p.H331N|MUC7_uc003hfj.2_Missense_Mutation_p.H331N|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	331	Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			TGCACCCACACACCAGACTAC	0.438			NA											47	71					3.94638e-17	5.53065e-17	0.00361	1	0
ENAM	10117	broad.mit.edu	37	4	71508260	71508260	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:71508260C>A	uc011caw.1	+	9	1398	c.1117C>A	c.(1117-1119)CGT>AGT	p.R373S		NM_031889	NP_114095	Q9NRM1	ENAM_HUMAN	enamelin precursor	373					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			ovary(3)	3			Lung(101;0.235)			ACAAGTAGCTCGTCCAGGAAA	0.438			NA											41	79					7.63091e-17	1.05869e-16	0.007835	1	0
UTP3	57050	broad.mit.edu	37	4	71555428	71555428	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:71555428A>T	uc003hfo.2	+	1	1233	c.1034A>T	c.(1033-1035)AAG>ATG	p.K345M		NM_020368	NP_065101	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit processome component	345					brain development|chromatin modification|gene silencing	nucleolus					0			Lung(101;0.235)			AAATCCACCAAGCCCAAACCA	0.403			NA											39	51					0	0	0.004878	0	0
CDKL2	8999	broad.mit.edu	37	4	76532444	76532444	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:76532444C>A	uc003hiq.2	-	4	990	c.465G>T	c.(463-465)GGG>GGT	p.G155G	CDKL2_uc011cbp.1_Silent_p.G155G|CDKL2_uc010iix.1_Intron	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	155	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TATAAACCTCCCCAGGAGCTG	0.453			NA											17	26					1.15088e-07	1.32252e-07	0.004007	1	0
FRAS1	80144	broad.mit.edu	37	4	79188481	79188481	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:79188481G>T	uc003hlb.2	+	9	1316	c.876G>T	c.(874-876)CGG>CGT	p.R292R	FRAS1_uc003hkw.2_Silent_p.R292R|FRAS1_uc003hky.1_5'UTR|FRAS1_uc003hkz.2_5'UTR	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	292	VWFC 5.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						GAGTTGTGCGGTACCAGGACG	0.572			NA											9	12					1.76689e-08	2.07605e-08	0.006214	1	0
WDFY3	23001	broad.mit.edu	37	4	85660262	85660262	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:85660262C>A	uc003hpd.2	-	40	6883	c.6475G>T	c.(6475-6477)GGA>TGA	p.G2159*		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2159						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGTCCAAATCCATCCACGTTG	0.413			NA											22	23					1.9806e-07	2.27328e-07	0.002299	1	0
SLC10A6	345274	broad.mit.edu	37	4	87746721	87746721	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:87746721T>A	uc003hqd.2	-	5	919	c.771A>T	c.(769-771)ACA>ACT	p.T257T		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	257	Cytoplasmic (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		CTAAGGAAATTGTCCTGCACC	0.378			NA											11	15					0	0	0.000978	0	0
ABCG2	9429	broad.mit.edu	37	4	89020572	89020572	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:89020572C>T	uc003hrg.2	-	12	1889	c.1396G>A	c.(1396-1398)GTG>ATG	p.V466M	ABCG2_uc003hrh.2_Missense_Mutation_p.V466M|ABCG2_uc003hrf.2_Missense_Mutation_p.V334M	NM_004827	NP_004818	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G, member 2	466	ABC transmembrane type-2.|Cytoplasmic (Potential).				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TAAGATGACACTCTGTAGTAT	0.353			NA											12	13					0	0	0.000978	0	0
FAM13A	10144	broad.mit.edu	37	4	89649693	89649693	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:89649693C>G	uc003hse.1	-	24	3271	c.3063G>C	c.(3061-3063)AAG>AAC	p.K1021N	FAM13A_uc011cdp.1_Missense_Mutation_p.K123N|FAM13A_uc003hsa.1_Missense_Mutation_p.K464N|FAM13A_uc003hsb.1_Missense_Mutation_p.K695N|FAM13A_uc003hsd.1_Missense_Mutation_p.K667N|FAM13A_uc003hsc.1_Missense_Mutation_p.K681N|FAM13A_uc011cdq.1_Missense_Mutation_p.K667N|FAM13A_uc003hsf.1_Missense_Mutation_p.K607N|FAM13AOS_uc003hry.1_RNA|FAM13AOS_uc003hrz.1_RNA	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	1021					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						CTCACATGGACTTGGAATCAG	0.547			NA											17	34					0	0	0.00499	0	0
FAM190A	401145	broad.mit.edu	37	4	91230220	91230220	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:91230220C>A	uc003hsv.3	+	2	1125	c.785C>A	c.(784-786)GCC>GAC	p.A262D	FAM190A_uc003hsu.3_Missense_Mutation_p.A262D|FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Missense_Mutation_p.A262D	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	262										large_intestine(1)|ovary(1)	2						GAATTTTTAGCCTTGACTGAA	0.438			NA											52	81					2.43139e-17	3.40995e-17	0.00361	1	0
FAM190A	401145	broad.mit.edu	37	4	91645125	91645125	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:91645125G>T	uc003hsv.3	+	7	2333	c.1993G>T	c.(1993-1995)GAG>TAG	p.E665*	FAM190A_uc010ikv.2_RNA|FAM190A_uc003hsw.2_Nonsense_Mutation_p.E665*|FAM190A_uc003hsx.2_RNA	NM_001145065	NP_001138537	Q9C0I3	F190A_HUMAN	KIAA1680 protein isoform 1	665										large_intestine(1)|ovary(1)	2						TCTTACTGAAGAGCCAGTGCC	0.333			NA											3	0					0.004672	0.0048062	0.004672	1	0
ATOH1	474	broad.mit.edu	37	4	94750813	94750813	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:94750813G>T	uc003hta.1	+	1	736	c.736G>T	c.(736-738)GGG>TGG	p.G246W		NM_005172	NP_005163	Q92858	ATOH1_HUMAN	atonal homolog 1	246					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity				0		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CTCCTATGAAGGGGGCGCGGG	0.716			NA											17	22					3.32936e-07	3.78318e-07	0.006122	1	0
PDHA2	5161	broad.mit.edu	37	4	96761908	96761908	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:96761908G>T	uc003htr.3	+	1	670	c.607G>T	c.(607-609)GCC>TCC	p.A203S		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	203					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GGGGCAGATAGCCGAAGCTTT	0.463			NA											20	28					1.56452e-12	1.99722e-12	0.007413	1	0
PDHA2	5161	broad.mit.edu	37	4	96762426	96762426	+	Silent	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:96762426T>G	uc003htr.3	+	1	1188	c.1125T>G	c.(1123-1125)GTT>GTG	p.V375V		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	375					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	CTTTTGAAGTTCGTGGTGCAA	0.413			NA											28	35					0	0	0.002445	0	0
TBCK	93627	broad.mit.edu	37	4	107092362	107092362	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:107092362T>A	uc010ilv.2	-	23	2490	c.2125A>T	c.(2125-2127)ACT>TCT	p.T709S	TBCK_uc003hyb.2_Missense_Mutation_p.T452S|TBCK_uc003hye.2_Missense_Mutation_p.T670S|TBCK_uc003hyc.2_Missense_Mutation_p.T646S|TBCK_uc003hyd.2_Missense_Mutation_p.T537S|TBCK_uc003hyf.2_Missense_Mutation_p.T709S	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	709						intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						TGTCTGTAAGTAGCACTTTTA	0.413			NA											18	46					0	0	0.010504	0	0
LEF1	51176	broad.mit.edu	37	4	108991910	108991910	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:108991910C>A	uc003hyt.1	-	9	1680	c.1025G>T	c.(1024-1026)CGT>CTT	p.R342L	LEF1_uc011cfj.1_Missense_Mutation_p.R199L|LEF1_uc011cfk.1_Missense_Mutation_p.R246L|LEF1_uc003hyu.1_Missense_Mutation_p.R314L|LEF1_uc003hyv.1_Missense_Mutation_p.R314L|LEF1_uc010imb.1_RNA|LEF1_uc003hys.1_RNA|LEF1_uc010ima.1_Missense_Mutation_p.R30L|LEF1_uc003hyw.1_RNA	NM_016269	NP_057353	Q9UJU2	LEF1_HUMAN	lymphoid enhancer-binding factor 1 isoform 1	342	HMG box.				canonical Wnt receptor signaling pathway|cell chemotaxis|cellular response to interleukin-4|epithelial to mesenchymal transition|histone H3 acetylation|histone H4 acetylation|negative regulation of apoptosis in bone marrow|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell-cell adhesion|negative regulation of DNA binding|negative regulation of estrogen receptor binding|negative regulation of interleukin-13 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of transcription, DNA-dependent|neutrophil differentiation|osteoblast differentiation|palate development|positive regulation by host of viral transcription|positive regulation of cell cycle process|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of cell proliferation in bone marrow|positive regulation of cell-cell adhesion|positive regulation of epithelial to mesenchymal transition|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|T-helper 1 cell differentiation	cytoplasm|protein-DNA complex|transcription factor complex	armadillo repeat domain binding|beta-catenin binding|C2H2 zinc finger domain binding|caspase inhibitor activity|DNA bending activity|enhancer binding|estrogen receptor activity|estrogen receptor binding|gamma-catenin binding|histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding			large_intestine(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000224)		CTGCTCTTCACGGGAGAGGGC	0.373			NA											19	29					5.03518e-11	6.25436e-11	0.007413	1	0
ENPEP	2028	broad.mit.edu	37	4	111441523	111441523	+	Splice_Site	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:111441523G>A	uc003iab.3	+	10	2069	c.1727_splice	c.e10+1	p.G576_splice		NM_001977	NP_001968	Q07075	AMPE_HUMAN	glutamyl aminopeptidase						cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			skin(3)|ovary(1)|breast(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	CAGATCTTGGGTAAGGCTCTA	0.388			NA											14	26					0	0	0.003163	0	0
ANK2	287	broad.mit.edu	37	4	114274342	114274342	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:114274342C>A	uc003ibe.3	+	38	4668	c.4568C>A	c.(4567-4569)ACA>AAA	p.T1523K	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Missense_Mutation_p.T1538K	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	1490					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATCTTGACCACAGATGTGTCT	0.443			NA											19	34					1.96292e-10	2.40424e-10	0.010504	1	0
ANK2	287	broad.mit.edu	37	4	114276758	114276758	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:114276758A>T	uc003ibe.3	+	38	7084	c.6984A>T	c.(6982-6984)ACA>ACT	p.T2328T	ANK2_uc003ibd.3_Intron|ANK2_uc003ibf.3_Intron|ANK2_uc011cgc.1_Intron|ANK2_uc003ibg.3_Intron|ANK2_uc003ibh.3_Intron|ANK2_uc011cgd.1_5'Flank|ANK2_uc011cgb.1_Silent_p.T2343T	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	2295					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		ATGATTGCACAGGCAGCTGTA	0.493			NA											15	22					0	0	0.00245	0	0
NDST4	64579	broad.mit.edu	37	4	115773944	115773944	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:115773944A>G	uc003ibu.2	-	8	2432	c.1753T>C	c.(1753-1755)TGG>CGG	p.W585R	NDST4_uc010imw.2_RNA	NM_022569	NP_072091	Q9H3R1	NDST4_HUMAN	heparan sulfate N-deacetylase/N-sulfotransferase	585	Lumenal (Potential).|Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			skin(3)|ovary(1)	4		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		TCTCTGGACCAGATGTCTTTG	0.358			NA											8	17					0	0	0.004482	0	0
KIAA1109	84162	broad.mit.edu	37	4	123193425	123193425	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:123193425C>T	uc003ieh.2	+	46	8356	c.8311C>T	c.(8311-8313)CAG>TAG	p.Q2771*	KIAA1109_uc003iel.1_Nonsense_Mutation_p.Q706*|KIAA1109_uc003iek.2_Nonsense_Mutation_p.Q1390*	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2771					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TTCTGAACCTCAGCATGTTAC	0.433			NA											12	18					0	0	0.00245	0	0
BBS12	166379	broad.mit.edu	37	4	123663745	123663745	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:123663745A>T	uc003ieu.2	+	2	891	c.698A>T	c.(697-699)CAC>CTC	p.H233L		NM_152618	NP_689831	Q6ZW61	BBS12_HUMAN	Bardet-Biedl syndrome 12	233					cellular protein metabolic process	cilium	ATP binding			ovary(2)	2						ATACTAATCCACAGTAGGCAT	0.388			NA							Bardet-Biedl_syndrome				18	29					0	0	0.00499	0	0
FAT4	79633	broad.mit.edu	37	4	126372061	126372061	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:126372061G>T	uc003ifj.3	+	9	9890	c.9890G>T	c.(9889-9891)CGT>CTT	p.R3297L	FAT4_uc011cgp.1_Missense_Mutation_p.R1595L|FAT4_uc003ifi.1_Missense_Mutation_p.R775L	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3297	Cadherin 31.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TATGTGCCCCGTTTTGTTTCC	0.403			NA											22	19					4.35082e-09	5.18452e-09	0.010504	1	0
FAT4	79633	broad.mit.edu	37	4	126397370	126397370	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:126397370A>T	uc003ifj.3	+	12	12252	c.12252A>T	c.(12250-12252)CCA>CCT	p.P4084P	FAT4_uc011cgp.1_Silent_p.P2347P|FAT4_uc003ifi.1_Silent_p.P1562P	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4084	Laminin G-like 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACCAAGAGCCAGGATATTGTA	0.348			NA											45	53					0	0	0.00361	0	0
FAT4	79633	broad.mit.edu	37	4	126408613	126408613	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:126408613G>A	uc003ifj.3	+	16	12930	c.12930G>A	c.(12928-12930)GGG>GGA	p.G4310G	FAT4_uc011cgp.1_Silent_p.G2551G|FAT4_uc003ifi.1_Silent_p.G1788G	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4310	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TTCTAATTGGGAAAAATGGAA	0.398			NA											9	31					0	0	0.000978	0	0
FAT4	79633	broad.mit.edu	37	4	126408659	126408659	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:126408659A>G	uc003ifj.3	+	16	12976	c.12976A>G	c.(12976-12978)AGA>GGA	p.R4326G	FAT4_uc011cgp.1_Missense_Mutation_p.R2567G|FAT4_uc003ifi.1_Missense_Mutation_p.R1804G	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4326	Laminin G-like 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AATATATAACAGAGATATTAT	0.418			NA											8	19					0	0	0.00308	0	0
INTU	27152	broad.mit.edu	37	4	128608933	128608933	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:128608933C>T	uc003ifk.1	+	8	1430	c.1360C>T	c.(1360-1362)CCC>TCC	p.P454S	INTU_uc011cgq.1_RNA	NM_015693	NP_056508	Q9ULD6	PDZD6_HUMAN	PDZ domain containing 6	454										ovary(1)	1						CAGCGCCAGTCCCAGTGCTCA	0.473			NA											26	35					0	0	0.00333	0	0
PCDH10	57575	broad.mit.edu	37	4	134073585	134073585	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:134073585G>T	uc003iha.2	+	1	3116	c.2290G>T	c.(2290-2292)GGT>TGT	p.G764C	PCDH10_uc003igz.2_Missense_Mutation_p.G764C	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	764	Cys-rich.|Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		CTGCTGCTGCGGTGGCGGAGG	0.587			NA											7	20					2.7689e-08	3.24352e-08	0.001984	1	0
PCDH18	54510	broad.mit.edu	37	4	138450988	138450988	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:138450988C>A	uc003ihe.3	-	1	2642	c.2255G>T	c.(2254-2256)CGG>CTG	p.R752L	PCDH18_uc003ihf.3_Missense_Mutation_p.R745L|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_Missense_Mutation_p.R532L|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	752	Cytoplasmic (Potential).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					GTGAATCTGCCGGGATGGCCT	0.483			NA											20	43					1.78486e-19	2.60326e-19	0.007413	1	0
MAML3	55534	broad.mit.edu	37	4	141074181	141074181	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:141074181C>A	uc003ihz.1	-	1	1053	c.301G>T	c.(301-303)GAG>TAG	p.E101*	MAML3_uc011chd.1_Nonsense_Mutation_p.E101*	NM_018717	NP_061187	Q96JK9	MAML3_HUMAN	mastermind-like 3	101					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			ovary(1)	1	all_hematologic(180;0.162)					TCCAGCTGCTCCACCTGAGCC	0.677			NA											6	1					0.00198382	0.00205832	0.001984	1	0
TBC1D9	23158	broad.mit.edu	37	4	141600249	141600249	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:141600249G>A	uc010ioj.2	-	5	970	c.698C>T	c.(697-699)TCT>TTT	p.S233F		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	233						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GAGGAATACAGAGAAGAAATG	0.473			NA											53	105					0	0	0.00361	0	0
POU4F2	5458	broad.mit.edu	37	4	147560530	147560530	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:147560530G>T	uc003ikv.2	+	1	486	c.238G>T	c.(238-240)GGC>TGC	p.G80C		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	80	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					tggcagcagcggcggcggggg	0.318			NA											10	17					2.27111e-07	2.59901e-07	0.001368	1	0
POU4F2	5458	broad.mit.edu	37	4	147561536	147561536	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:147561536G>T	uc003ikv.2	+	2	1054	c.806G>T	c.(805-807)CGC>CTC	p.R269L		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	269	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					AAGCAGCGACGCATCAAGCTG	0.687			NA											7	15					5.18039e-06	5.70876e-06	0.00308	1	0
LRBA	987	broad.mit.edu	37	4	151604712	151604712	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:151604712G>A	uc010ipj.2	-	37	6386	c.5912C>T	c.(5911-5913)TCT>TTT	p.S1971F	LRBA_uc003ilt.3_Missense_Mutation_p.S630F|LRBA_uc003ilu.3_Missense_Mutation_p.S1971F	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1971						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					CCTCACTGCAGAATTTCCCCA	0.403			NA											9	71					0	0	0.006214	0	0
ARFIP1	27236	broad.mit.edu	37	4	153803926	153803926	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:153803926G>C	uc003imz.2	+	7	961	c.685G>C	c.(685-687)GAG>CAG	p.E229Q	ARFIP1_uc003inb.2_Missense_Mutation_p.E197Q|ARFIP1_uc003ina.2_Missense_Mutation_p.E197Q|ARFIP1_uc003inc.2_Missense_Mutation_p.E229Q|ARFIP1_uc011cij.1_Missense_Mutation_p.E49Q	NM_001025595	NP_001020766	P53367	ARFP1_HUMAN	ADP-ribosylation factor interacting protein 1	229	AH.				intracellular protein transport|regulation of protein secretion	cytosol|Golgi membrane				ovary(1)	1	all_hematologic(180;0.093)					TAAAAATGGAGAGACTCTTCT	0.338			NA											8	20					0	0	0.00308	0	0
SFRP2	6423	broad.mit.edu	37	4	154709967	154709967	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:154709967C>G	uc003inv.1	-	1	262	c.21G>C	c.(19-21)TCG>TCC	p.S7S		NM_003013	NP_003004	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2 precursor	7					brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			ovary(1)|central_nervous_system(1)	2	all_hematologic(180;0.093)	Renal(120;0.117)				GCAGCAGCAGCGAGCCAGGGC	0.711			NA											11	4					0	0	0.008291	0	0
FGA	2243	broad.mit.edu	37	4	155507680	155507680	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:155507680C>A	uc003iod.1	-	5	959	c.901G>T	c.(901-903)GGA>TGA	p.G301*	FGA_uc003ioe.1_Nonsense_Mutation_p.G301*|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	301	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	CTTCCAGGTCCAGAGCTCCCA	0.572	NSCLC(143;340 1922 20892 22370 48145)		NA											52	79					4.02871e-13	5.18743e-13	0.00361	1	0
FSTL5	56884	broad.mit.edu	37	4	162577480	162577480	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:162577480A>G	uc003iqh.2	-	7	1330	c.894T>C	c.(892-894)AAT>AAC	p.N298N	FSTL5_uc003iqi.2_Silent_p.N297N|FSTL5_uc010iqv.2_Silent_p.N297N	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	298	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		ATGTACTCACATTGATGTCTT	0.348			NA											3	8					0	0	0.004672	0	0
FSTL5	56884	broad.mit.edu	37	4	162577485	162577485	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:162577485T>G	uc003iqh.2	-	7	1325	c.889A>C	c.(889-891)ATC>CTC	p.I297L	FSTL5_uc003iqi.2_Missense_Mutation_p.I296L|FSTL5_uc010iqv.2_Missense_Mutation_p.I296L	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	297	Ig-like 1.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CTCACATTGATGTCTTCCAAA	0.338			NA											4	7					0	0	0.009096	0	0
ANP32C	23520	broad.mit.edu	37	4	165118530	165118530	+	Nonsense_Mutation	SNP	T	T	A	rs138319123		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:165118530T>A	uc011cjk.1	-	1	334	c.334A>T	c.(334-336)AAG>TAG	p.K112*	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	112	LRR 4.										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		TCTAAGCTCTTGAGGTTTTCT	0.418			NA											46	22					0	0	0.002852	0	0
IRF2	3660	broad.mit.edu	37	4	185339812	185339812	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:185339812T>A	uc003iwf.3	-	4	438	c.238A>T	c.(238-240)AAT>TAT	p.N80Y		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	80	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		CATCTGAAATTCGCCTTCCAT	0.388			NA											12	4					0	0	0.001368	0	0
ACSL1	2180	broad.mit.edu	37	4	185687118	185687118	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:185687118C>A	uc003iww.2	-	14	1580	c.1286G>T	c.(1285-1287)CGG>CTG	p.R429L	ACSL1_uc011ckm.1_Missense_Mutation_p.R258L|ACSL1_uc003iwt.1_Missense_Mutation_p.R429L|ACSL1_uc003iwu.1_Missense_Mutation_p.R429L|ACSL1_uc011ckn.1_Missense_Mutation_p.R395L|ACSL1_uc003iws.1_5'UTR	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	429	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CACCATCAGCCGGACTCTTCC	0.647			NA											27	17					1.5548e-18	2.2307e-18	0.005443	1	0
PDLIM3	27295	broad.mit.edu	37	4	186429513	186429513	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:186429513T>C	uc003ixw.3	-	5	726	c.602A>G	c.(601-603)AAT>AGT	p.N201S	PDLIM3_uc003ixx.3_Intron|PDLIM3_uc010isi.2_Intron	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	201						sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		TTCCATAATATTGTCATCTGA	0.418			NA											30	14					0	0	0.007291	0	0
AHRR	57491	broad.mit.edu	37	5	433020	433020	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:433020G>T	uc003jav.2	+	11	1180	c.1136G>T	c.(1135-1137)CGG>CTG	p.R379L	AHRR_uc003jaw.2_Missense_Mutation_p.R357L|AHRR_uc010isy.2_Missense_Mutation_p.R207L|AHRR_uc010isz.2_Missense_Mutation_p.R357L|AHRR_uc003jax.2_Missense_Mutation_p.R120L|AHRR_uc003jay.2_Missense_Mutation_p.R217L|AHRR_uc003jaz.2_5'UTR	NM_020731	NP_065782	A9YTQ3	AHRR_HUMAN	arylhydrocarbon receptor repressor	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)	2			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			CTGTGCCTCCGGGGTGGCCCT	0.672			NA											22	36					1.50039e-11	1.88181e-11	0.001882	1	0
TERT	7015	broad.mit.edu	37	5	1293516	1293516	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:1293516G>A	uc003jcb.1	-	2	1543	c.1485C>T	c.(1483-1485)ATC>ATT	p.I495I	TERT_uc003jca.1_Silent_p.I495I|TERT_uc003jcc.1_Silent_p.I495I|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	495	Required for oligomerization.|RNA-interacting domain 2.|QFP motif.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			TCCCCAGGGAGATGAACTTCT	0.667			NA							TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				30	42					0	0	0.002096	0	0
TERT	7015	broad.mit.edu	37	5	1294381	1294381	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:1294381A>T	uc003jcb.1	-	2	678	c.620T>A	c.(619-621)GTC>GAC	p.V207D	TERT_uc003jca.1_Missense_Mutation_p.V207D|TERT_uc003jcc.1_Missense_Mutation_p.V207D|TERT_uc003jcd.1_RNA|TERT_uc003jce.1_RNA	NM_198253	NP_937983	O14746	TERT_HUMAN	telomerase reverse transcriptase isoform 1	207	RNA-interacting domain 1.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			lung(7)|ovary(2)|central_nervous_system(2)|skin(1)	12	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGCCTCCCTGACGCTATGGTT	0.736			NA							TERT_Mutation-Associated_Haematological_Disorders|Congenital_Dyskeratosis|Pulmonary_Fibrosis_Idiopathic				12	20					0	0	0.00245	0	0
LPCAT1	79888	broad.mit.edu	37	5	1501688	1501688	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:1501688C>A	uc003jcm.2	-	2	283	c.166G>T	c.(166-168)GTC>TTC	p.V56F		NM_024830	NP_079106	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	56	Cytoplasmic (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		AGGAGCCGGACCGGGAAGAGC	0.662			NA											42	40					9.85913e-13	1.26275e-12	0.009718	1	0
ADCY2	108	broad.mit.edu	37	5	7626323	7626323	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:7626323G>C	uc003jdz.1	+	4	681	c.614G>C	c.(613-615)GGA>GCA	p.G205A		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	205	Helical; (Potential).			VWQILANVIIFICGNLAGAY -> GLADPGQCDHFHLWEPG XTN (in Ref. 1; AAP97285).	activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AACCTGGCGGGAGCCTACCAT	0.443			NA											55	110					0	0	0.00361	0	0
MTRR	4552	broad.mit.edu	37	5	7897015	7897015	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:7897015G>T	uc003jed.2	+	13	1826	c.1796G>T	c.(1795-1797)GGA>GTA	p.G599V	MTRR_uc003jee.3_Missense_Mutation_p.G572V|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	599					methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GGAAATTTTGGAGCAATGTGG	0.348			NA											33	48					1.30998e-17	1.84928e-17	0.005524	1	0
SEMA5A	9037	broad.mit.edu	37	5	9066620	9066620	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:9066620C>A	uc003jek.2	-	17	2924	c.2212G>T	c.(2212-2214)GCT>TCT	p.A738S		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	738	TSP type-1 4.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						TTCGGATCAGCCAGGCGGGCT	0.542			NA											83	116					1.68737e-39	2.98024e-39	0.00361	1	0
ROPN1L	83853	broad.mit.edu	37	5	10465002	10465002	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:10465002C>A	uc003jex.3	+	5	907	c.636C>A	c.(634-636)TTC>TTA	p.F212L		NM_031916	NP_114122	Q96C74	ROP1L_HUMAN	ropporin 1-like	212					ciliary or flagellar motility|signal transduction	cytoplasm|motile cilium	cAMP-dependent protein kinase regulator activity|protein binding			ovary(1)	1						CAGATTTCTTCTTTCCAAAGA	0.318			NA											31	99					2.81731e-10	3.442e-10	0.002096	1	0
CTNND2	1501	broad.mit.edu	37	5	10973694	10973694	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:10973694G>T	uc003jfa.1	-	22	3694	c.3549C>A	c.(3547-3549)AGC>AGA	p.S1183R	CTNND2_uc010itt.2_Missense_Mutation_p.S1092R|CTNND2_uc011cmy.1_Missense_Mutation_p.S846R|CTNND2_uc011cmz.1_Missense_Mutation_p.S750R|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.S775R	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1183					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TGGTGTACTCGCTGGCGGGAG	0.522			NA											47	64					9.58827e-17	1.3274e-16	0.00361	1	0
CTNND2	1501	broad.mit.edu	37	5	11082867	11082867	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:11082867C>A	uc003jfa.1	-	16	2874	c.2729G>T	c.(2728-2730)TGC>TTC	p.C910F	CTNND2_uc010itt.2_Missense_Mutation_p.C819F|CTNND2_uc011cmy.1_Missense_Mutation_p.C573F|CTNND2_uc011cmz.1_Missense_Mutation_p.C477F|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Missense_Mutation_p.C502F	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	910	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						GGCCACCGCGCACACCACACG	0.527			NA											40	78					2.6416e-12	3.35888e-12	0.00623	1	0
CTNND2	1501	broad.mit.edu	37	5	11565065	11565065	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:11565065C>G	uc003jfa.1	-	3	423	c.278G>C	c.(277-279)AGC>ACC	p.S93T	CTNND2_uc010itt.2_Missense_Mutation_p.S2T|CTNND2_uc011cmy.1_Missense_Mutation_p.S2T|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	93					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						CCTCATGCTGCTCATGCTGCC	0.542			NA											16	39					0	0	0.004007	0	0
DNAH5	1767	broad.mit.edu	37	5	13769204	13769204	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:13769204C>A	uc003jfd.2	-	58	9804	c.9762G>T	c.(9760-9762)AAG>AAT	p.K3254N	DNAH5_uc003jfc.2_Translation_Start_Site	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3254	Stalk (By similarity).|Potential.				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CAGCCTTGACCTTTTCAGCAG	0.423			NA							Kartagener_syndrome				158	354					3.54725e-78	6.66056e-78	0.00361	1	0
DNAH5	1767	broad.mit.edu	37	5	13891206	13891206	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:13891206C>A	uc003jfd.2	-	17	2498	c.2456G>T	c.(2455-2457)AGG>ATG	p.R819M		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	819	Potential.|Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATCATTGACCCTGTCAAGCAG	0.388			NA							Kartagener_syndrome				72	124					9.07738e-34	1.55222e-33	0.00361	1	0
FBXL7	23194	broad.mit.edu	37	5	15928421	15928422	+	Nonsense_Mutation	DNP	GT	GT	TA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GT	GT	-	-	GT	GT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:15928421_15928422GT>TA	uc003jfn.1	+	3	1031_1032	c.550_551GT>TA	c.(550-552)GTG>TAG	p.V184*		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	184	LRR 1.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CACCCCCAACGTGTGTCTCATG	0.649			NA											21	27					0	0	0.004672	0	0
CDH18	1016	broad.mit.edu	37	5	19721528	19721528	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:19721528A>C	uc003jgc.2	-	4	948	c.571T>G	c.(571-573)TAT>GAT	p.Y191D	CDH18_uc003jgd.2_Missense_Mutation_p.Y191D|CDH18_uc011cnm.1_Missense_Mutation_p.Y191D	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	191	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTGTTTCCATAGGTAGGGTCA	0.448			NA											22	95					0	0	0.001882	0	0
CDH10	1008	broad.mit.edu	37	5	24487969	24487969	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:24487969C>A	uc003jgr.1	-	12	2502	c.2170G>T	c.(2170-2172)GAC>TAC	p.D724Y	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	724	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		GCGGTGGGGTCAAGATCATGC	0.448			NA								HNSCC(23;0.051)			41	76					7.63091e-17	1.05869e-16	0.007835	1	0
CDH10	1008	broad.mit.edu	37	5	24491847	24491847	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:24491847C>A	uc003jgr.1	-	11	2046	c.1714G>T	c.(1714-1716)GAT>TAT	p.D572Y	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	572	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		ATTGGGTAATCATTGTCTGAT	0.433			NA								HNSCC(23;0.051)			23	41					7.41877e-09	8.79241e-09	0.001882	1	0
CDH9	1007	broad.mit.edu	37	5	26916033	26916033	+	Splice_Site	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:26916033C>A	uc003jgs.1	-	3	398	c.229_splice	c.e3-1	p.L77_splice	CDH9_uc010iug.2_Splice_Site_p.L77_splice	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						CAGTGTGAAGCTTTAGAGAGG	0.343	Melanoma(8;187 585 15745 40864 52829)		NA											13	67					1.5842e-08	1.8682e-08	0.001855	1	0
PDZD2	23037	broad.mit.edu	37	5	31799605	31799605	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:31799605G>T	uc003jhl.2	+	2	638	c.250G>T	c.(250-252)GGC>TGC	p.G84C	PDZD2_uc003jhm.2_Missense_Mutation_p.G84C	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	84					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGAGACTGTGGGCCTGAGTTT	0.572			NA											130	132					1.83689e-69	3.42911e-69	0.00361	1	0
ZFR	51663	broad.mit.edu	37	5	32390460	32390460	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:32390460C>A	uc003jhr.1	-	12	2143	c.2063G>T	c.(2062-2064)GGT>GTT	p.G688V	ZFR_uc011cny.1_5'Flank	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	688					multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		ATGAGGATAACCTCCATCTGG	0.532			NA											39	85					2.05212e-20	3.05292e-20	0.005524	1	0
ZFR	51663	broad.mit.edu	37	5	32417849	32417849	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:32417849T>C	uc003jhr.1	-	4	549	c.469A>G	c.(469-471)AGT>GGT	p.S157G	ZFR_uc010iun.1_Missense_Mutation_p.S157G	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	157	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		TATTGCTTACTATCATAAGCT	0.438			NA											83	163					0	0	0.00361	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33527374	33527374	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33527374G>T	uc003jia.1	-	24	4867	c.4704C>A	c.(4702-4704)TGC>TGA	p.C1568*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.C1483*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1568	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						GACACGAGAAGCAGCACTCAG	0.493			NA								HNSCC(64;0.19)			101	306					4.49162e-49	8.17197e-49	0.00361	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577021	33577021	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33577021C>A	uc003jia.1	-	19	3273	c.3110G>T	c.(3109-3111)GGG>GTG	p.G1037V	ADAMTS12_uc010iuq.1_Missense_Mutation_p.G952V	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1037	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGACTCAGGCCCTGTGGGTGT	0.527			NA								HNSCC(64;0.19)			90	111					7.63117e-38	1.32961e-37	0.00361	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33588798	33588798	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33588798G>T	uc003jia.1	-	18	2934	c.2771C>A	c.(2770-2772)ACA>AAA	p.T924K	ADAMTS12_uc010iuq.1_Missense_Mutation_p.T839K	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	924	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CTGGCAGTCTGTGGGCGGGAG	0.627			NA								HNSCC(64;0.19)			31	207					5.60225e-13	7.19439e-13	0.009535	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33624397	33624397	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33624397G>C	uc003jia.1	-	14	2245	c.2082C>G	c.(2080-2082)TGC>TGG	p.C694W	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	694	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CATCTCCCAGGCACACACCGC	0.512			NA								HNSCC(64;0.19)			33	108					0	0	0.002445	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33630890	33630890	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33630890A>T	uc003jia.1	-	13	2180	c.2017T>A	c.(2017-2019)TGT>AGT	p.C673S	ADAMTS12_uc010iuq.1_Intron	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	673	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AATACCTTACATATGCCATTA	0.383			NA								HNSCC(64;0.19)			31	112					0	0	0.007291	0	0
SLC45A2	51151	broad.mit.edu	37	5	33963842	33963842	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33963842G>T	uc003jid.2	-	3	934	c.842C>A	c.(841-843)CCA>CAA	p.P281Q	SLC45A2_uc003jie.2_Missense_Mutation_p.P281Q|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	281	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						TGCCAGCTCTGGATTTACGTA	0.408	Ovarian(31;380 859 8490 22203 49048)		NA											64	303					5.44642e-36	9.4048e-36	0.00361	1	0
SLC45A2	51151	broad.mit.edu	37	5	33963844	33963844	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33963844A>G	uc003jid.2	-	3	932	c.840T>C	c.(838-840)AAT>AAC	p.N280N	SLC45A2_uc003jie.2_Silent_p.N280N|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	280	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CCAGCTCTGGATTTACGTAAC	0.408	Ovarian(31;380 859 8490 22203 49048)		NA											61	307					0	0	0.00361	0	0
SLC45A2	51151	broad.mit.edu	37	5	33982417	33982417	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:33982417G>T	uc003jid.2	-	2	578	c.486C>A	c.(484-486)CCC>CCA	p.P162P	SLC45A2_uc003jie.2_Silent_p.P162P|SLC45A2_uc003jif.3_Silent_p.P162P|SLC45A2_uc011coe.1_Silent_p.P162P	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	162	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						AGGCTTTGATGGGCCCATCAA	0.483	Ovarian(31;380 859 8490 22203 49048)		NA											25	71					4.72057e-08	5.48983e-08	0.003954	1	0
AGXT2	64902	broad.mit.edu	37	5	35003936	35003936	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35003936C>T	uc003jjf.2	-	13	1448	c.1369G>A	c.(1369-1371)GTA>ATA	p.V457I	AGXT2_uc003jje.1_Missense_Mutation_p.V110I|AGXT2_uc011com.1_Missense_Mutation_p.V382I	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	457					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	ATCTGATTTACTTCTTCACGG	0.408			NA									OREG0016558	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	181					0	0	0.00361	0	0
AGXT2	64902	broad.mit.edu	37	5	35014196	35014196	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35014196G>T	uc003jjf.2	-	10	1071	c.992C>A	c.(991-993)TCT>TAT	p.S331Y	AGXT2_uc003jje.1_5'UTR|AGXT2_uc011com.1_Intron	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	331					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	CCAGAAGTGAGAGCCCAACCT	0.448			NA											40	123					7.04047e-22	1.07384e-21	0.005524	1	0
AGXT2	64902	broad.mit.edu	37	5	35039598	35039598	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35039598G>T	uc003jjf.2	-	3	272	c.193C>A	c.(193-195)CGT>AGT	p.R65S	AGXT2_uc011com.1_Missense_Mutation_p.R65S|AGXT2_uc011con.1_5'UTR	NM_031900	NP_114106	Q9BYV1	AGT2_HUMAN	alanine-glyoxylate aminotransferase 2 precursor	65					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(3)|skin(1)	4	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	TCCAGGACACGGTTGTAGCCA	0.473			NA											33	94					1.22384e-17	1.73272e-17	0.002836	1	0
SPEF2	79925	broad.mit.edu	37	5	35641549	35641549	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35641549C>A	uc003jjo.2	+	3	289	c.178C>A	c.(178-180)CTT>ATT	p.L60I	SPEF2_uc003jjn.1_Missense_Mutation_p.L60I|SPEF2_uc003jjq.3_Missense_Mutation_p.L60I	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	60	CH.				nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AAGTGCCAAACTTAATAATTT	0.373			NA											25	91					7.33532e-06	8.06969e-06	0.003954	1	0
IL7R	3575	broad.mit.edu	37	5	35876488	35876488	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35876488C>T	uc003jjs.2	+	8	1369	c.1280C>T	c.(1279-1281)ACA>ATA	p.T427I	IL7R_uc011cop.1_RNA	NM_002185	NP_002176	P16871	IL7RA_HUMAN	interleukin 7 receptor precursor	427	Cytoplasmic (Potential).				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			ovary(3)|breast(1)|skin(1)	5	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			GGAATCCTGACATTGAACCCA	0.502			NA											31	80					0	0	0.002096	0	0
CAPSL	133690	broad.mit.edu	37	5	35921107	35921107	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35921107G>C	uc003jjt.1	-	2	211	c.116C>G	c.(115-117)GCT>GGT	p.A39G	CAPSL_uc003jju.1_Missense_Mutation_p.A39G	NM_001042625	NP_001036090	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	39	EF-hand 1.					cytoplasm	calcium ion binding			skin(1)	1	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TTTGATCCCAGCAGAGCCCCT	0.498			NA											49	118					0	0	0.00361	0	0
UGT3A1	133688	broad.mit.edu	37	5	35968221	35968221	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:35968221C>A	uc003jjv.1	-	3	368	c.211G>T	c.(211-213)GAA>TAA	p.E71*	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Nonsense_Mutation_p.E71*|UGT3A1_uc011cor.1_Nonsense_Mutation_p.E37*|UGT3A1_uc003jjy.1_Nonsense_Mutation_p.E17*	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	71	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TATGATTTTTCCTCCTCTTTA	0.299			NA											25	18					3.6726e-16	5.03746e-16	0.003954	1	0
UGT3A2	167127	broad.mit.edu	37	5	36035965	36035965	+	Silent	SNP	C	C	A	rs138782726		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:36035965C>A	uc003jjz.1	-	7	1500	c.1407G>T	c.(1405-1407)ACG>ACT	p.T469T	UGT3A2_uc011cos.1_Silent_p.T435T|UGT3A2_uc011cot.1_Silent_p.T167T	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	469	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCTTGAGGTGCGTCGCGCCCC	0.622			NA											34	50					9.04072e-19	1.30483e-18	0.003271	1	0
UGT3A2	167127	broad.mit.edu	37	5	36052023	36052023	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:36052023C>A	uc003jjz.1	-	3	353	c.260G>T	c.(259-261)AGA>ATA	p.R87I	UGT3A2_uc011cos.1_Missense_Mutation_p.R53I|UGT3A2_uc011cot.1_5'UTR	NM_174914	NP_777574	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	87	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)	6	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTTAAATTCTCTTTGATGATC	0.284			NA											8	73					0.000157383	0.000167241	0.00308	1	0
FYB	2533	broad.mit.edu	37	5	39202061	39202061	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:39202061C>A	uc003jls.2	-	1	1069	c.1002G>T	c.(1000-1002)AAG>AAT	p.K334N	FYB_uc003jlt.2_Missense_Mutation_p.K334N|FYB_uc003jlu.2_Missense_Mutation_p.K334N|FYB_uc011cpl.1_Missense_Mutation_p.K344N	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	334					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TCTTGTCTCCCTTTTCCTTTT	0.552			NA											28	109					1.88708e-17	2.65814e-17	0.008361	1	0
TTC33	23548	broad.mit.edu	37	5	40728524	40728524	+	Missense_Mutation	SNP	C	C	A	rs139469375		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:40728524C>A	uc003jma.2	-	4	506	c.358G>T	c.(358-360)GTC>TTC	p.V120F	TTC33_uc011cpm.1_Missense_Mutation_p.V12F|TTC33_uc010ivg.2_Intron	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	120	TPR 2.						binding			ovary(1)	1						TTTTGCTGGACGGCCATTTCT	0.403			NA											14	65					0.00185496	0.00192979	0.001855	1	0
C7	730	broad.mit.edu	37	5	40964925	40964925	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:40964925C>G	uc003jmh.2	+	14	1946	c.1832C>G	c.(1831-1833)GCC>GGC	p.A611G	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	611	Sushi 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AACCCAGTGGCCAGATGTGGA	0.398			NA											86	166					0	0	0.00361	0	0
C7	730	broad.mit.edu	37	5	40981659	40981659	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:40981659C>G	uc003jmh.2	+	18	2630	c.2516C>G	c.(2515-2517)GCT>GGT	p.A839G		NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	839	Complement control factor I module 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				AGGCCTTGTGCTGCGGAAACC	0.587			NA											4	41					0	0	0.009096	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41005676	41005676	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:41005676G>T	uc003jmj.3	-	35	4311	c.3821C>A	c.(3820-3822)TCC>TAC	p.S1274Y	HEATR7B2_uc003jmi.3_Missense_Mutation_p.S829Y	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	1274	HEAT 14.						binding			ovary(6)|central_nervous_system(2)	8						GTTCTCCGAGGAGGAGGTAAG	0.512			NA											9	14					0.000673444	0.000705548	0.008291	1	0
HEATR7B2	133558	broad.mit.edu	37	5	41045901	41045901	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:41045901T>A	uc003jmj.3	-	18	2273	c.1783A>T	c.(1783-1785)ACT>TCT	p.T595S	HEATR7B2_uc003jmi.3_Missense_Mutation_p.T150S	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	595	HEAT 7.						binding			ovary(6)|central_nervous_system(2)	8						AAATCCTGAGTCAGCTGAATG	0.393			NA											181	110					0	0	0.00361	0	0
C6	729	broad.mit.edu	37	5	41154084	41154084	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:41154084C>T	uc003jmk.2	-	15	2328	c.2118G>A	c.(2116-2118)AAG>AAA	p.K706K	C6_uc003jml.1_Silent_p.K706K	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	706	C5b-binding domain.|Sushi 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCACAACTGGCTTGATGCACT	0.413			NA											14	76					0	0	0.00245	0	0
C6	729	broad.mit.edu	37	5	41160350	41160350	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:41160350G>T	uc003jmk.2	-	11	1788	c.1578C>A	c.(1576-1578)TGC>TGA	p.C526*	C6_uc003jml.1_Nonsense_Mutation_p.C526*	NM_000065	NP_000056	P13671	CO6_HUMAN	complement component 6 precursor	526	EGF-like.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			ovary(3)|central_nervous_system(2)|skin(2)	7		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				CATTATTAGGGCATGGAGCAC	0.493			NA											78	184					7.62465e-47	1.37557e-46	0.00361	1	0
MGC42105	167359	broad.mit.edu	37	5	43245913	43245913	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:43245913G>T	uc003jno.2	+	2	917	c.36G>T	c.(34-36)GTG>GTT	p.V12V		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	12							ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						GTGGCCTGGTGAACCCCCACT	0.607			NA											86	227					5.56898e-48	1.00846e-47	0.00361	1	0
FGF10	2255	broad.mit.edu	37	5	44388620	44388620	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:44388620G>A	uc003jog.1	-	1	165	c.165C>T	c.(163-165)TCC>TCT	p.S55S		NM_004465	NP_004456	O15520	FGF10_HUMAN	fibroblast growth factor 10 precursor	55	Poly-Ser.				actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			lung(3)	3	Lung NSC(6;1.12e-06)					AGGAGAAGGAGGAGGAAGAAG	0.537			NA											57	32					0	0	0.00361	0	0
ITGA1	3672	broad.mit.edu	37	5	52216286	52216286	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:52216286C>T	uc003jou.2	+	17	2332	c.2280C>T	c.(2278-2280)TCC>TCT	p.S760S	ITGA1_uc003jov.2_RNA|ITGA1_uc003jow.2_Silent_p.S291S	NM_181501	NP_852478	P56199	ITA1_HUMAN	integrin, alpha 1 precursor	760	Extracellular (Potential).				axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			ovary(2)|lung(1)	3		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				CTAAGCACTCCTTCTACATGT	0.348			NA											15	44					0	0	0.00245	0	0
HSPB3	8988	broad.mit.edu	37	5	53751941	53751941	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:53751941G>T	uc003jph.1	+	1	497	c.322G>T	c.(322-324)GGT>TGT	p.G108C		NM_006308	NP_006299	Q12988	HSPB3_HUMAN	heat shock 27kDa protein 3	108					cell death|response to heat|response to unfolded protein	cytoplasm|nucleus					0		Lung NSC(810;0.00104)				GGATGAGCACGGTTTTATCTC	0.473			NA											31	175					1.99505e-19	2.90544e-19	0.002445	1	0
SNX18	112574	broad.mit.edu	37	5	53839209	53839209	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:53839209C>A	uc003jpi.3	+	2	2012	c.1822C>A	c.(1822-1824)CAA>AAA	p.Q608K	SNX18_uc011cqg.1_3'UTR	NM_001102575	NP_001096045	Q96RF0	SNX18_HUMAN	sorting nexin 18 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication|endocytosis|positive regulation of GTPase activity|protein transport	endomembrane system|endosome membrane|extrinsic to internal side of plasma membrane	phosphatidylinositol binding|protein binding				0		Lung NSC(810;3.46e-05)|Breast(144;0.102)				AATATTTTTCCAAAAAGTTAC	0.343			NA											14	98					7.93312e-07	8.90979e-07	0.00245	1	0
HTR1A	3350	broad.mit.edu	37	5	63257032	63257032	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:63257032A>C	uc011cqt.1	-	1	515	c.515T>G	c.(514-516)ATG>AGG	p.M172R		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	172	Helical; Name=4; (By similarity).			M -> I (in Ref. 1; AAA36440/CAA31908).	behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	CCAGCCCAGCATGGGCGGGAT	0.597			NA											101	31					0	0	0.00361	0	0
PDE8B	8622	broad.mit.edu	37	5	76633113	76633113	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:76633113G>C	uc003kfa.2	+	6	815	c.770G>C	c.(769-771)GGG>GCG	p.G257A	PDE8B_uc003kfb.2_Missense_Mutation_p.G237A|PDE8B_uc003kfc.2_Missense_Mutation_p.G257A|PDE8B_uc003kfd.2_Missense_Mutation_p.G257A|PDE8B_uc003kfe.2_Missense_Mutation_p.G257A	NM_003719	NP_003710	O95263	PDE8B_HUMAN	phosphodiesterase 8B isoform 1	257					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity				0		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		ATAGAACATGGGGAAGTTCGC	0.333			NA											11	0					0	0	0.000978	0	0
OTP	23440	broad.mit.edu	37	5	76932818	76932818	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:76932818G>T	uc003kfg.2	-	2	423	c.275C>A	c.(274-276)CCC>CAC	p.P92H		NM_032109	NP_115485	Q5XKR4	OTP_HUMAN	orthopedia homeobox	92						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)	1		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		GGCTTGGCTGGGGTTCGGGCC	0.697			NA											69	25					8.3131e-28	1.36135e-27	0.00361	1	0
CMYA5	202333	broad.mit.edu	37	5	79027442	79027442	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:79027442G>T	uc003kgc.2	+	2	2926	c.2854G>T	c.(2854-2856)GTG>TTG	p.V952L		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	952						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TTCTGCATTTGTGTCAGAATT	0.398			NA											40	11					3.76604e-16	5.16195e-16	0.002522	1	0
ACOT12	134526	broad.mit.edu	37	5	80641822	80641822	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:80641822G>T	uc003khl.3	-	7	710	c.655C>A	c.(655-657)CGC>AGC	p.R219S	RNU5E_uc011cto.1_Intron	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	219	Acyl coenzyme A hydrolase 2.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		CAACACAGGCGGCTGGGGAGA	0.443			NA											23	6					7.4402e-23	1.14383e-22	0.003954	1	0
VCAN	1462	broad.mit.edu	37	5	82836030	82836030	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:82836030C>A	uc003kii.3	+	8	7564	c.7208C>A	c.(7207-7209)GCT>GAT	p.A2403D	VCAN_uc003kij.3_Missense_Mutation_p.A1416D|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.A1067D	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2403	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GATTTTCTGGCTAGAGCTTAT	0.383			NA											21	5					3.10358e-05	3.37399e-05	0.002299	1	0
VCAN	1462	broad.mit.edu	37	5	82837494	82837494	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:82837494C>G	uc003kii.3	+	8	9028	c.8672C>G	c.(8671-8673)TCT>TGT	p.S2891C	VCAN_uc003kij.3_Missense_Mutation_p.S1904C|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.S1555C	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2891	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAGCCTCCCTCTTTATCTCCT	0.383			NA											44	10					0	0	0.003214	0	0
GPR98	84059	broad.mit.edu	37	5	89989938	89989938	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:89989938C>T	uc003kju.2	+	33	7461	c.7365C>T	c.(7363-7365)TTC>TTT	p.F2455F	GPR98_uc003kjt.2_Silent_p.F161F|GPR98_uc003kjv.2_Silent_p.F55F	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	2455	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TTTCATTTTTCAGTGCTTCTG	0.493			NA											18	8					0	0	0.006122	0	0
MCTP1	79772	broad.mit.edu	37	5	94208896	94208896	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:94208896T>A	uc003kkx.2	-	13	1984	c.1984A>T	c.(1984-1986)ACA>TCA	p.T662S	MCTP1_uc003kkv.2_Missense_Mutation_p.T441S|MCTP1_uc003kkw.2_Missense_Mutation_p.T395S|MCTP1_uc003kkz.2_Missense_Mutation_p.T323S|MCTP1_uc003kku.2_Missense_Mutation_p.T178S	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	662	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		ACAGTATGTGTTAGCAGTCTA	0.353			NA											13	10					0	0	0.001855	0	0
APC	324	broad.mit.edu	37	5	112175950	112175950	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:112175950A>G	uc010jby.2	+	16	5039	c.4659A>G	c.(4657-4659)GCA>GCG	p.A1553A	APC_uc011cvt.1_Silent_p.A1535A|APC_uc003kpz.3_Silent_p.A1553A|APC_uc003kpy.3_Silent_p.A1553A|APC_uc010jbz.2_Silent_p.A1270A|APC_uc010jca.2_Silent_p.A853A	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	1553	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1554fs*11(1)|p.K1192fs*3(1)|p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		AGAAAGAGGCAGAAAAAACTA	0.338	NSCLC(107;854 1218 9699 17025 28335 47076 52975)|Esophageal Squamous(32;282 584 32991 36563 39392 49665 50115)		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			16	8					0	0	0.004007	0	0
TSSK1B	83942	broad.mit.edu	37	5	112769886	112769886	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:112769886G>A	uc003kqm.2	-	1	843	c.651C>T	c.(649-651)GAC>GAT	p.D217D	MCC_uc003kql.3_Intron	NM_032028	NP_114417	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1	217	Protein kinase.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|skin(2)|stomach(1)	5		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		TGTTGGAGTCGTCGTAGGGCA	0.577			NA											37	2					0	0	0.007835	0	0
DMXL1	1657	broad.mit.edu	37	5	118513159	118513159	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:118513159C>T	uc003ksd.2	+	27	7047	c.6866C>T	c.(6865-6867)ACG>ATG	p.T2289M	DMXL1_uc010jcl.1_Missense_Mutation_p.T2289M	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	2289										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		ACTCCCAATACGTCACCAGCT	0.353			NA											16	2					0	0	0.007413	0	0
SLC12A2	6558	broad.mit.edu	37	5	127449957	127449957	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:127449957G>C	uc003kus.2	+	3	1094	c.930G>C	c.(928-930)TGG>TGC	p.W310C	SLC12A2_uc010jdf.2_RNA|SLC12A2_uc010jdg.2_Missense_Mutation_p.W310C	NM_001046	NP_001037	P55011	S12A2_HUMAN	solute carrier family 12	310	Extracellular (Potential).				potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			ovary(3)	3		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	GATTGTCATGGATTGTGGGTC	0.378			NA											30	54					0	0	0.008361	0	0
FBN2	2201	broad.mit.edu	37	5	127611786	127611786	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:127611786T>A	uc003kuu.2	-	59	7977	c.7538A>T	c.(7537-7539)TAT>TTT	p.Y2513F		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2513	EGF-like 42; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGAACACTGATAACTCCCCTC	0.453			NA											52	7					0	0	0.00361	0	0
SLC27A6	28965	broad.mit.edu	37	5	128368848	128368848	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:128368848T>C	uc003kuy.2	+	11	2129	c.1733T>C	c.(1732-1734)GTG>GCG	p.V578A	SLC27A6_uc003kuz.2_Missense_Mutation_p.V578A	NM_014031	NP_054750	Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid	578					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding				0		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CATCAGTTGGTGGAAGATGGA	0.323			NA											24	2					0	0	0.005443	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037211	129037211	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:129037211C>A	uc003kvb.1	+	20	3067	c.3067C>A	c.(3067-3069)CCC>ACC	p.P1023T	ADAMTS19_uc010jdh.1_RNA	NM_133638	NP_598377	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1023	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|breast(2)|lung(1)|skin(1)	9		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CTGCATTGGGCCCAAGCCCGC	0.582			NA											39	11					5.44703e-19	7.88514e-19	0.009718	1	0
CHSY3	337876	broad.mit.edu	37	5	129520888	129520888	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:129520888G>T	uc003kvd.2	+	3	2053	c.2053G>T	c.(2053-2055)GAA>TAA	p.E685*		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	685	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		CCCCAAAGCAGAAATGACCCT	0.438			NA											36	2					4.65686e-17	6.48407e-17	0.003755	1	0
TRPC7	57113	broad.mit.edu	37	5	135601950	135601950	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:135601950G>C	uc003lbn.1	-	4	1303	c.1300C>G	c.(1300-1302)CAG>GAG	p.Q434E	TRPC7_uc010jef.1_Missense_Mutation_p.Q371E|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.Q365E|TRPC7_uc010jei.1_Missense_Mutation_p.Q310E|TRPC7_uc010jej.1_Intron	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	435	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CAGGAGAACTGTGTGGTTTTC	0.378			NA											60	20					0	0	0.00361	0	0
TRPC7	57113	broad.mit.edu	37	5	135651404	135651405	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:135651404_135651405GG>TT	uc003lbn.1	-	2	843_844	c.840_841CC>AA	c.(838-843)TGCCGA>TGAAGA	p.C280*	TRPC7_uc010jef.1_Nonsense_Mutation_p.C272*|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Intron|TRPC7_uc010jei.1_Intron|TRPC7_uc010jej.1_Intron	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	281	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TCTGTGTCTCGGCACAGGTCCA	0.48			NA											21	4					0	0	0.004672	0	0
TRPC7	57113	broad.mit.edu	37	5	135692480	135692480	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:135692480T>A	uc003lbn.1	-	1	596	c.593A>T	c.(592-594)AAG>ATG	p.K198M	TRPC7_uc010jef.1_Missense_Mutation_p.K190M|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Missense_Mutation_p.K190M|TRPC7_uc010jei.1_Missense_Mutation_p.K190M|TRPC7_uc010jej.1_Translation_Start_Site	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	199	Cytoplasmic (Potential).				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTCATTGCACTTGCAGAAGTA	0.607			NA											54	12					0	0	0.00361	0	0
WNT8A	7478	broad.mit.edu	37	5	137420278	137420278	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:137420278G>T	uc003lcd.1	+	3	199	c.194G>T	c.(193-195)TGC>TTC	p.C65F	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Missense_Mutation_p.C83F|WNT8A_uc011cyk.1_Missense_Mutation_p.C83F	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	65					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CGCTGGAACTGCCCTGAAAAT	0.527			NA											48	5					2.01872e-29	3.34263e-29	0.00361	1	0
PAIP2	51247	broad.mit.edu	37	5	138704432	138704432	+	Missense_Mutation	SNP	A	A	T	rs151272131		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:138704432A>T	uc003led.2	+	4	506	c.329A>T	c.(328-330)AAT>ATT	p.N110I	PAIP2_uc003lee.2_Missense_Mutation_p.N110I|PAIP2_uc003lef.2_Missense_Mutation_p.N110I|SLC23A1_uc003leh.2_Intron|SLC23A1_uc003leg.2_Intron	NM_016480	NP_057564	Q9BPZ3	PAIP2_HUMAN	poly(A) binding protein interacting protein 2	110	PABPC1-interacting motif-2 (PAM2).				negative regulation of translational initiation	cytoplasm	protein binding|translation repressor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTCAAGAGCAATCTGAATCCA	0.388			NA											38	11					0	0	0.002522	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255556	140255556	+	Missense_Mutation	SNP	C	C	A	rs17844352		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140255556C>A	uc003lic.2	+	1	626	c.499C>A	c.(499-501)CTT>ATT	p.L167I	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc011daf.1_Missense_Mutation_p.L167I	NM_018903	NP_061726	Q9UN75	PCDAC_HUMAN	protocadherin alpha 12 isoform 1 precursor	167	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTAAACTCTCTTTTGACCTA	0.378	Pancreas(113;759 1672 13322 24104 50104)		NA											47	14					8.78508e-14	1.1449e-13	0.00361	1	0
PCDHA13	56136	broad.mit.edu	37	5	140262281	140262281	+	Missense_Mutation	SNP	C	C	A	rs140980938		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140262281C>A	uc003lif.2	+	1	428	c.428C>A	c.(427-429)GCA>GAA	p.A143E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A143E|PCDHA13_uc003lid.2_Missense_Mutation_p.A143E	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	143	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATAATCATTGCAGAATCTAGA	0.493	Melanoma(147;1739 1852 5500 27947 37288)		NA											58	15					5.39261e-20	7.93707e-20	0.00361	1	0
PCDHB2	56133	broad.mit.edu	37	5	140475165	140475166	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140475165_140475166CC>GA	uc003lil.2	+	1	929_930	c.791_792CC>GA	c.(790-792)GCC>GGA	p.A264G	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	264	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCCCAGGTTGCCATCGTCTCTG	0.47			NA											35	8					0	0	0.004672	0	0
PCDHB3	56132	broad.mit.edu	37	5	140482211	140482211	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140482211G>A	uc003lio.2	+	1	1978	c.1978G>A	c.(1978-1980)GTG>ATG	p.V660M	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	660	Extracellular (Potential).|Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACGCTGCATGTGCTCCTGGT	0.711			NA											109	18					0	0	0.00361	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515629	140515629	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140515629C>A	uc003liq.2	+	1	830	c.613C>A	c.(613-615)CGG>AGG	p.R205R		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	205	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGGAGGAGCGGCCTGAGCT	0.542			NA											76	8					7.46257e-40	1.31925e-39	0.00361	1	0
PCDHB16	57717	broad.mit.edu	37	5	140562593	140562593	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140562593T>C	uc003liv.2	+	1	1614	c.459T>C	c.(457-459)CCT>CCC	p.P153P	PCDHB16_uc010jfw.1_Intron	NM_020957	NP_066008	Q9NRJ7	PCDBG_HUMAN	protocadherin beta 16 precursor	153	Extracellular (Potential).|Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGAGTTCCCTCTGAATCATG	0.393			NA											21	7					0	0	0.010504	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574112	140574112	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140574112G>T	uc003lix.2	+	1	2161	c.1987G>T	c.(1987-1989)GTG>TTG	p.V663L		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	663	Cadherin 6.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTGCTCCTGGTGGACGGCTT	0.697			NA											89	19					5.56898e-48	1.00846e-47	0.00361	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140774034	140774034	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140774034G>T	uc003lkd.1	+	1	2552	c.1654G>T	c.(1654-1656)GTG>TTG	p.V552L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Missense_Mutation_p.V552L	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	552	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCCTGTTCGTGCTGGACCA	0.637			NA											120	28					3.59472e-76	6.74315e-76	0.00361	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140774159	140774159	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140774159G>T	uc003lkd.1	+	1	2677	c.1779G>T	c.(1777-1779)GCG>GCT	p.A593A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkb.3_Silent_p.A593A	NM_032088	NP_114477	Q9Y5G5	PCDG8_HUMAN	protocadherin gamma subfamily A, 8 isoform 1	593	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGGTGGCGGTGGACAGAG	0.692			NA											39	73					1.57019e-19	2.29189e-19	0.007835	1	0
PCDHGB5	56101	broad.mit.edu	37	5	140778168	140778168	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140778168A>T	uc003lkf.1	+	1	474	c.474A>T	c.(472-474)GAA>GAT	p.E158D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc011daw.1_Missense_Mutation_p.E158D	NM_018925	NP_061748	Q9Y5G0	PCDGH_HUMAN	protocadherin gamma subfamily B, 5 isoform 1	158	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGTAGCAGAAGATGCAGATA	0.378			NA											44	16					0	0	0.002522	0	0
PCDH1	5097	broad.mit.edu	37	5	141244741	141244741	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:141244741G>A	uc003llq.2	-	3	1272	c.1155C>T	c.(1153-1155)CCC>CCT	p.P385P	PCDH1_uc003llp.2_Silent_p.P385P|PCDH1_uc011dbf.1_Silent_p.P363P	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	385	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCTCAATGGTGGGGGCATTGT	0.582	Ovarian(132;1609 1739 4190 14731 45037)		NA											78	12					0	0	0.00361	0	0
PCDH12	51294	broad.mit.edu	37	5	141334615	141334615	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:141334615G>C	uc003llx.2	-	1	4013	c.2802C>G	c.(2800-2802)AGC>AGG	p.S934R		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	934	Cytoplasmic (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGGACCAGGCTCCGCAGGA	0.627			NA											33	8					0	0	0.005524	0	0
TCERG1	10915	broad.mit.edu	37	5	145838514	145838514	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:145838514A>T	uc003lob.2	+	4	546	c.506A>T	c.(505-507)CAG>CTG	p.Q169L	TCERG1_uc003loc.2_Missense_Mutation_p.Q169L|TCERG1_uc011dbt.1_Missense_Mutation_p.Q169L	NM_006706	NP_006697	O14776	TCRG1_HUMAN	transcription elongation regulator 1 isoform 1	169	Ala/Gln-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			ovary(1)|skin(1)	2		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGGTTATTCAGCAATCAGAA	0.264			NA											65	18					0	0	0.00361	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146017943	146017943	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:146017943G>T	uc003loe.2	-	6	1186	c.661C>A	c.(661-663)CTC>ATC	p.L221I	PPP2R2B_uc010jgm.2_Missense_Mutation_p.L210I|PPP2R2B_uc003log.3_Missense_Mutation_p.L221I|PPP2R2B_uc003lof.3_Missense_Mutation_p.L221I|PPP2R2B_uc003loi.3_Missense_Mutation_p.L224I|PPP2R2B_uc003loh.3_Missense_Mutation_p.L221I|PPP2R2B_uc003loj.3_Missense_Mutation_p.L201I|PPP2R2B_uc003lok.3_Missense_Mutation_p.L210I|PPP2R2B_uc011dbu.1_Missense_Mutation_p.L227I|PPP2R2B_uc011dbv.1_Missense_Mutation_p.L279I	NM_004576	NP_004567	Q00005	2ABB_HUMAN	beta isoform of regulatory subunit B55, protein	221	WD 4.				apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)|prostate(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCTCCGTGAGCTCCTCCATG	0.552			NA											24	21					0.00465635	0.00480031	0.004656	1	0
SPINK9	643394	broad.mit.edu	37	5	147718114	147718114	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:147718114G>A	uc003lpe.1	+	3	216	c.161G>A	c.(160-162)TGT>TAT	p.C54Y	uc003lpb.1_Intron	NM_001040433	NP_001035523	Q5DT21	ISK9_HUMAN	serine peptidase inhibitor, Kazal type 9	54	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCCAATTTGTGGATCTGAT	0.279			NA											14	8					0	0	0.006122	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148743716	148743716	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:148743716G>A	uc003lqk.2	+	3	475	c.413G>A	c.(412-414)GGC>GAC	p.G138D	PCYOX1L_uc003lql.2_Missense_Mutation_p.G121D|PCYOX1L_uc010jgz.2_Missense_Mutation_p.G121D|PCYOX1L_uc003lqm.2_Missense_Mutation_p.G20D|PCYOX1L_uc003lqn.2_Missense_Mutation_p.G48D	NM_024028	NP_076933	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like precursor	138					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCACTATGGCATCAGCTTC	0.612	Ovarian(62;1136 1477 27277 27495)		NA											38	8					0	0	0.005524	0	0
CSNK1A1	1452	broad.mit.edu	37	5	148930456	148930456	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:148930456C>G	uc003lqx.1	-	1	552	c.72G>C	c.(70-72)GGG>GGC	p.G24G	CSNK1A1_uc011dcc.1_5'Flank|CSNK1A1_uc003lqv.1_5'Flank|CSNK1A1_uc003lqw.1_Silent_p.G24G|CSNK1A1_uc003lqy.1_Silent_p.G24G|CSNK1A1_uc010jha.1_Silent_p.G24G	NM_001892	NP_001883	P48729	KC1A_HUMAN	casein kinase 1, alpha 1 isoform 2	24	ATP (By similarity).|Protein kinase.				cell division|mitosis|Wnt receptor signaling pathway	centrosome|condensed chromosome kinetochore|cytosol|nuclear speck	ATP binding|protein binding|protein binding|protein serine/threonine kinase activity			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		AGGAGCCAGACCCGATCTTCC	0.537	Colon(5;64 69 1309 10383)		NA											29	97					0	0	0.009535	0	0
CSF1R	1436	broad.mit.edu	37	5	149435882	149435882	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:149435882G>C	uc003lrl.2	-	17	2537	c.2342C>G	c.(2341-2343)GCG>GGG	p.A781G	CSF1R_uc011dcd.1_Intron|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.A781G	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	781	Protein kinase.|Cytoplasmic (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CACGTTACGCGCTGCCACGTC	0.572			NA											18	30					0	0	0.006122	0	0
MYOZ3	91977	broad.mit.edu	37	5	150056314	150056314	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:150056314C>A	uc003lss.2	+	7	1220	c.633C>A	c.(631-633)CCC>CCA	p.P211P	MYOZ3_uc003lsr.2_Silent_p.P211P	NM_001122853	NP_001116325	Q8TDC0	MYOZ3_HUMAN	myozenin 3	211						sarcomere	protein binding			skin(1)	1		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACTTTTCCCAGGCCAGGCA	0.637			NA											87	18					5.00163e-47	9.04033e-47	0.00361	1	0
FAT2	2196	broad.mit.edu	37	5	150905469	150905469	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:150905469G>A	uc003lue.3	-	17	10379	c.10366C>T	c.(10366-10368)CCA>TCA	p.P3456S	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.P149S	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3456	Extracellular (Potential).|Cadherin 31.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCATTCTCTGGAGAATCTGGG	0.567			NA											20	18					0	0	0.008871	0	0
GLRA1	2741	broad.mit.edu	37	5	151266335	151266335	+	Missense_Mutation	SNP	C	C	T	rs142888296		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:151266335C>T	uc003lut.2	-	3	486	c.199G>A	c.(199-201)GTG>ATG	p.V67M	GLRA1_uc003lur.2_Missense_Mutation_p.V67M|GLRA1_uc003lus.2_Translation_Start_Site	NM_001146040	NP_001139512	P23415	GLRA1_HUMAN	glycine receptor, alpha 1 isoform 1 precursor	67	Extracellular (Probable).				muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			ovary(1)|central_nervous_system(1)	2		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TTGCAGCTCACGTTCACTGGG	0.488			NA											57	12					0	0	0.00361	0	0
KIF4B	285643	broad.mit.edu	37	5	154397119	154397119	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:154397119C>T	uc010jih.1	+	1	3860	c.3700C>T	c.(3700-3702)CAC>TAC	p.H1234Y		NM_001099293	NP_001092763	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1234	Interaction with PRC1 (By similarity).|Globular (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			ovary(1)	1	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AGAAGAGGCCCACTGAAGTTG	0.478			NA											3	1					0	0	0.004672	0	0
ADAM19	8728	broad.mit.edu	37	5	156964947	156964947	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:156964947G>T	uc003lwz.2	-	4	368	c.304C>A	c.(304-306)CCT>ACT	p.P102T	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Missense_Mutation_p.P33T	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	102					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTTTGAGGGTTACCACTT	0.443			NA											20	14					3.62473e-10	4.41729e-10	0.001882	1	0
RNF145	153830	broad.mit.edu	37	5	158596030	158596030	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:158596030C>A	uc003lxp.2	-	8	1285	c.972G>T	c.(970-972)CTG>CTT	p.L324L	RNF145_uc011ddy.1_Silent_p.L338L|RNF145_uc003lxo.1_Silent_p.L352L|RNF145_uc011ddz.1_Silent_p.L341L|RNF145_uc010jiq.1_Silent_p.L354L	NM_144726	NP_653327	Q96MT1	RN145_HUMAN	ring finger protein 145	324	Helical; (Potential).					integral to membrane	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0523)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTGCACTGCCAGGATTAACA	0.378			NA											34	15					1.69901e-12	2.16747e-12	0.005524	1	0
ADRA1B	147	broad.mit.edu	37	5	159344455	159344455	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:159344455C>A	uc003lxt.1	+	1	716	c.543C>A	c.(541-543)CTC>CTA	p.L181L		NM_000679	NP_000670	P35368	ADA1B_HUMAN	alpha-1B-adrenergic receptor	181	Helical; Name=4; (By similarity).				cell proliferation|cell-cell signaling|G-protein signaling, coupled to cAMP nucleotide second messenger|intracellular protein kinase cascade	integral to plasma membrane	alpha1-adrenergic receptor activity			lung(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Guanfacine(DB01018)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Modafinil(DB00745)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Olanzapine(DB00334)|Phendimetrazine(DB01579)|Phenylephrine(DB00388)|Prazosin(DB00457)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Trazodone(DB00656)	TCGGGCCTCTCCTTGGGTGGA	0.602			NA											29	6					7.38237e-10	8.91786e-10	0.00632	1	0
SLIT3	6586	broad.mit.edu	37	5	168114084	168114084	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:168114084C>T	uc003mab.2	-	30	3634	c.3214G>A	c.(3214-3216)GAG>AAG	p.E1072K	SLIT3_uc010jjg.2_Missense_Mutation_p.E1079K	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1072	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGTCTGTCTCACAGAGCTTC	0.597	Ovarian(29;311 847 10864 17279 24903)		NA											13	5					0	0	0.001368	0	0
SLIT3	6586	broad.mit.edu	37	5	168123328	168123328	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:168123328G>A	uc003mab.2	-	28	3471	c.3051C>T	c.(3049-3051)AAC>AAT	p.N1017N	SLIT3_uc010jjg.2_Silent_p.N1024N	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1017	EGF-like 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TACACACGTAGTTGTTGATCC	0.517	Ovarian(29;311 847 10864 17279 24903)		NA											35	13					0	0	0.004878	0	0
SLIT3	6586	broad.mit.edu	37	5	168180966	168180966	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:168180966C>A	uc003mab.2	-	17	2152	c.1732G>T	c.(1732-1734)GAT>TAT	p.D578Y	SLIT3_uc010jjg.2_Missense_Mutation_p.D578Y	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	578	LRR 13.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCTGCTCCATCGAAAGCTCCC	0.532	Ovarian(29;311 847 10864 17279 24903)		NA											8	6					5.18039e-06	5.70876e-06	0.00308	1	0
DOCK2	1794	broad.mit.edu	37	5	169145713	169145713	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:169145713C>T	uc003maf.2	+	22	2265	c.2185C>T	c.(2185-2187)CAA>TAA	p.Q729*	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Nonsense_Mutation_p.Q221*	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	729					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAGAGGGGAGCAATGTGAGCC	0.388			NA											34	5					0	0	0.002445	0	0
DOCK2	1794	broad.mit.edu	37	5	169507216	169507216	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:169507216C>A	uc003maf.2	+	50	5296	c.5216C>A	c.(5215-5217)GCG>GAG	p.A1739E	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.A1231E|DOCK2_uc003mah.2_Missense_Mutation_p.A295E	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1739					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCGGAGCATGCGGCCATCCCC	0.557			NA											40	13					1.15183e-24	1.81848e-24	0.009718	1	0
STC2	8614	broad.mit.edu	37	5	172752989	172752989	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:172752989T>A	uc003mco.1	-	2	1486	c.176A>T	c.(175-177)AAC>ATC	p.N59I	STC2_uc003mcn.1_5'UTR	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	59					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			ATCGCCAGCGTTGACCAAACA	0.443			NA											112	25					0	0	0.00361	0	0
STC2	8614	broad.mit.edu	37	5	172755091	172755091	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:172755091C>A	uc003mco.1	-	1	1416	c.106G>T	c.(106-108)GAC>TAC	p.D36Y	STC2_uc003mcn.1_5'Flank	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	36					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GAGCTCCTGTCTTGGGGACCC	0.667			NA											72	20					2.32478e-39	4.09483e-39	0.00361	1	0
CDHR2	54825	broad.mit.edu	37	5	176011191	176011191	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:176011191G>A	uc003mem.1	+	18	2125	c.2059G>A	c.(2059-2061)GAC>AAC	p.D687N	CDHR2_uc003men.1_Missense_Mutation_p.D687N	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	687	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						CTGACTGCAGGACATCAATGA	0.537			NA											29	11					0	0	0.008361	0	0
HK3	3101	broad.mit.edu	37	5	176308945	176308945	+	Missense_Mutation	SNP	C	C	A	rs141851478	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:176308945C>A	uc003mfa.2	-	16	2329	c.2237G>T	c.(2236-2238)AGG>ATG	p.R746M	HK3_uc003mez.2_Missense_Mutation_p.R302M	NM_002115	NP_002106	P52790	HXK3_HUMAN	hexokinase 3	746	Catalytic.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			ovary(3)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	7	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGCCCACACCTCTGCTTGCC	0.637			NA											49	10					8.04919e-23	1.23647e-22	0.00361	1	0
FGFR4	2264	broad.mit.edu	37	5	176520231	176520231	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:176520231C>T	uc003mfl.2	+	9	1317	c.1150C>T	c.(1150-1152)CTG>TTG	p.L384L	FGFR4_uc003mfm.2_Silent_p.L384L|FGFR4_uc011dfu.1_Intron|FGFR4_uc011dfw.1_3'UTR|FGFR4_uc003mfo.2_Intron	NM_002011	NP_002002	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4 isoform 1	384	Helical; (Potential).				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			lung(11)|stomach(1)|central_nervous_system(1)|breast(1)|skin(1)|prostate(1)	16	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	GGCTGTGCTCCTGCTGCTGGC	0.706			NA								TSP Lung(9;0.080)			34	7					0	0	0.002445	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178553074	178553074	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:178553074C>A	uc003mjw.2	-	18	2675	c.2675G>T	c.(2674-2676)CGT>CTT	p.R892L		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	892	TSP type-1 2.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ACAGAAGCCACGGTGTACCAT	0.657			NA											56	17					2.5401e-28	4.17024e-28	0.00361	1	0
CANX	821	broad.mit.edu	37	5	179146685	179146685	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:179146685G>C	uc003mkk.2	+	9	1105	c.928G>C	c.(928-930)GCT>CCT	p.A310P	CANX_uc011dgp.1_Missense_Mutation_p.A345P|CANX_uc010jlb.1_Missense_Mutation_p.A246P|CANX_uc003mkl.2_Missense_Mutation_p.A310P|CANX_uc011dgq.1_Missense_Mutation_p.A202P	NM_001746	NP_001737	P27824	CALX_HUMAN	calnexin precursor	310	4 X approximate repeats.|P domain (Extended arm) (By similarity).|Lumenal (Potential).				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding				0	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGATGCCCCTGCTAAGATTCC	0.438			NA											12	5					0	0	0.000978	0	0
DUSP22	56940	broad.mit.edu	37	6	350826	350826	+	Silent	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:350826T>G	uc003msx.2	+	8	952	c.513T>G	c.(511-513)GCT>GCG	p.A171A	DUSP22_uc003msy.1_3'UTR	NM_020185	NP_064570	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	171					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		TCACAGCCGCTCCGGGAATTC	0.398			NA											19	67					0	0	0.00333	0	0
RREB1	6239	broad.mit.edu	37	6	7230981	7230981	+	Silent	SNP	G	G	T	rs139120793	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:7230981G>T	uc003mxc.2	+	10	3039	c.2649G>T	c.(2647-2649)TCG>TCT	p.S883S	RREB1_uc003mxb.2_Silent_p.S883S|RREB1_uc010jnx.2_Silent_p.S883S	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	883					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CCCATGTCTCGATCAAGTTGG	0.612			NA											15	75					4.7546e-09	5.65871e-09	0.004007	1	0
DSP	1832	broad.mit.edu	37	6	7583592	7583592	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:7583592G>A	uc003mxp.1	+	24	6376	c.6097G>A	c.(6097-6099)GAG>AAG	p.E2033K	DSP_uc003mxq.1_Missense_Mutation_p.E1434K	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	2033	Plectin 1.|Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CTCTTTGGTAGAGGCCAAGAG	0.478			NA											72	40					0	0	0.00361	0	0
GCNT2	2651	broad.mit.edu	37	6	10529945	10529945	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:10529945G>T	uc010joo.2	+	3	1352	c.801G>T	c.(799-801)GTG>GTT	p.V267V	GCNT2_uc010jol.2_Intron|GCNT2_uc010jom.2_Intron|GCNT2_uc010jop.2_Intron|GCNT2_uc003mza.2_Intron|GCNT2_uc003mzc.3_Silent_p.V266V|GCNT2_uc010jon.2_Silent_p.V266V	NM_145649	NP_663624	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2,	267	Lumenal (Potential).					Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)	2	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		CGGCCTACGTGGCTCTCACAA	0.453			NA											30	131					1.75199e-13	2.26948e-13	0.007291	1	0
DEK	7913	broad.mit.edu	37	6	18250037	18250037	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:18250037C>A	uc003ncr.1	-	7	800	c.607G>T	c.(607-609)GGC>TGC	p.G203C	DEK_uc011djf.1_Missense_Mutation_p.G169C|DEK_uc011djg.1_RNA	NM_003472	NP_003463	P35659	DEK_HUMAN	DEK oncogene isoform 1	203					chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			kidney(1)	1	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			TTTTTACTGCCTTTGCTACAA	0.348			NA	T	NUP214	AML								20	28					8.00594e-06	8.79744e-06	0.007413	1	0
ID4	3400	broad.mit.edu	37	6	19838366	19838366	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:19838366G>T	uc003ncw.2	+	1	750	c.381G>T	c.(379-381)CCG>CCT	p.P127P		NM_001546	NP_001537	P47928	ID4_HUMAN	inhibitor of DNA binding 4, dominant negative	127							transcription corepressor activity				0	Ovarian(93;0.0355)|Breast(50;0.0654)|all_epithelial(95;0.12)		OV - Ovarian serous cystadenocarcinoma(7;0.00659)|all cancers(50;0.0327)|Epithelial(50;0.0621)			CACACCACCCGGCCGGGACCT	0.602	Esophageal Squamous(13;105 518 19978 28644 46870)		NA											14	20					3.27435e-08	3.81942e-08	0.00245	1	0
NRSN1	140767	broad.mit.edu	37	6	24134624	24134624	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:24134624C>A	uc010jpq.1	+	3	306	c.69C>A	c.(67-69)CGC>CGA	p.R23R		NM_080723	NP_542454	Q8IZ57	NRSN1_HUMAN	neurensin 1	23					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle					0						GTTACCAGCGCTATGGAGTCC	0.522			NA											11	62					0.000978159	0.00102147	0.000978	1	0
FAM65B	9750	broad.mit.edu	37	6	24865573	24865573	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:24865573C>G	uc003neo.1	-	7	696	c.520G>C	c.(520-522)GAG>CAG	p.E174Q	FAM65B_uc011djs.1_Missense_Mutation_p.E203Q|FAM65B_uc011dju.1_Missense_Mutation_p.E208Q|FAM65B_uc003nep.2_Missense_Mutation_p.E174Q|FAM65B_uc011djt.1_Missense_Mutation_p.E174Q	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	174					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						GTCAGACTCTCCCGGGCAGCT	0.512			NA											40	75					0	0	0.007835	0	0
LRRC16A	55604	broad.mit.edu	37	6	25450173	25450173	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:25450173G>T	uc011djw.1	+	6	795	c.419G>T	c.(418-420)AGT>ATT	p.S140I	LRRC16A_uc010jpx.2_Missense_Mutation_p.S140I|LRRC16A_uc010jpy.2_Missense_Mutation_p.S140I|LRRC16A_uc003nez.1_5'Flank	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	140					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						CGCCTGGCTAGTCTCCAGGCG	0.493			NA											29	28					4.39465e-27	7.12426e-27	0.002836	1	0
SLC17A3	10786	broad.mit.edu	37	6	25862500	25862500	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:25862500A>T	uc003nfi.3	-	3	374	c.264T>A	c.(262-264)TTT>TTA	p.F88L	SLC17A3_uc003nfk.3_Missense_Mutation_p.F88L|SLC17A3_uc011djz.1_Missense_Mutation_p.F88L|SLC17A3_uc011dka.1_Missense_Mutation_p.F88L	NM_006632	NP_006623	O00476	NPT4_HUMAN	solute carrier family 17 (sodium phosphate),	88					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity				0						TTAGGCCACCAAATGAGTCAA	0.413			NA											23	55					0	0	0.00333	0	0
HIST1H2AD	3013	broad.mit.edu	37	6	26199333	26199333	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:26199333C>A	uc003ngw.2	-	1	139	c.139G>T	c.(139-141)GGC>TGC	p.G47C	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	47					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				ACTGGCGCGCCGGCCCCGACT	0.667			NA											45	75					4.18559e-23	6.45014e-23	0.00361	1	0
ZNF165	7718	broad.mit.edu	37	6	28053315	28053315	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:28053315T>A	uc003nkg.2	+	3	1141	c.57T>A	c.(55-57)CTT>CTA	p.L19L	ZNF165_uc003nkh.2_Silent_p.L19L|ZNF165_uc003nki.3_Silent_p.L19L	NM_003447	NP_003438	P49910	ZN165_HUMAN	zinc finger protein 165	19					viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ATGAAGGACTTCTGATAGTGA	0.438			NA											188	83					0	0	0.00361	0	0
PGBD1	84547	broad.mit.edu	37	6	28269009	28269009	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:28269009G>T	uc003nky.2	+	7	1748	c.1378G>T	c.(1378-1380)GTG>TTG	p.V460L	PGBD1_uc003nkz.2_Missense_Mutation_p.V460L	NM_032507	NP_115896	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	460					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			ovary(4)	4						AATGAGGTGTGTGTTTGGTGT	0.378			NA											27	102					1.26454e-06	1.41775e-06	0.005443	1	0
SCAND3	114821	broad.mit.edu	37	6	28541454	28541454	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:28541454C>T	uc003nlo.2	-	4	2830	c.2212G>A	c.(2212-2214)GAT>AAT	p.D738N		NM_052923	NP_443155	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	738					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			ovary(1)	1						tatgaaggatcatatttccga	0			NA											11	38					0	0	0.000978	0	0
OR2J2	26707	broad.mit.edu	37	6	29141996	29141996	+	Missense_Mutation	SNP	C	C	A	rs149241559	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:29141996C>A	uc011dlm.1	+	1	686	c.584C>A	c.(583-585)GCA>GAA	p.A195E		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GACACCCATGCAAATGAGCTG	0.478			NA											130	71					8.54645e-47	1.54043e-46	0.00361	1	0
LTB	4050	broad.mit.edu	37	6	31548635	31548635	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:31548635C>A	uc003nuk.2	-	4	594	c.586G>T	c.(586-588)GGG>TGG	p.G196W	LTB_uc003nul.2_3'UTR	NM_002341	NP_002332	Q06643	TNFC_HUMAN	lymphotoxin-beta isoform a	196	Extracellular (Potential).				cell-cell signaling|immune response|positive regulation of interleukin-12 biosynthetic process|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding				0					Infliximab(DB00065)|Simvastatin(DB00641)	GGCCCGTACCCTTGTCTCCTG	0.692			NA											9	36					3.09899e-07	3.5297e-07	0.004482	1	0
VARS	7407	broad.mit.edu	37	6	31749678	31749678	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:31749678C>A	uc003nxe.2	-	19	2716	c.2293G>T	c.(2293-2295)GAG>TAG	p.E765*	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_RNA	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	765					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	GCTGCCTTCTCCCGGGCCTCC	0.627			NA											186	102					5.28991e-74	9.90386e-74	0.00361	1	0
NOTCH4	4855	broad.mit.edu	37	6	32168997	32168997	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:32168997G>T	uc003obb.2	-	22	4175	c.4036C>A	c.(4036-4038)CGG>AGG	p.R1346R	NOTCH4_uc003oba.2_Silent_p.R9R|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1346	Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TCTTCAGCCCGGGCCCCAGGA	0.622			NA											44	55					9.9998e-32	1.68757e-31	0.002852	1	0
NOTCH4	4855	broad.mit.edu	37	6	32188025	32188025	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:32188025T>A	uc003obb.2	-	7	1335	c.1196A>T	c.(1195-1197)CAG>CTG	p.Q399L	NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA|NOTCH4_uc003obc.2_Missense_Mutation_p.Q399L	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	399	EGF-like 10.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						ATGGCACGGCTGGCTCAGACA	0.617			NA											22	74					0	0	0.001882	0	0
C6orf10	10665	broad.mit.edu	37	6	32261590	32261590	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:32261590T>A	uc011dpy.1	-	12	1033	c.860A>T	c.(859-861)AAA>ATA	p.K287I	C6orf10_uc011dpx.1_Missense_Mutation_p.K69I	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	287						integral to membrane				skin(1)	1						CATTCCTATTTTGTCTTTCTC	0.393			NA											243	103					0	0	0.00361	0	0
BTNL2	56244	broad.mit.edu	37	6	32370752	32370752	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:32370752G>A	uc003obg.1	-	3	669	c.669C>T	c.(667-669)CCC>CCT	p.P223P	BTNL2_uc010jty.1_Intron|BTNL2_uc010jtz.1_Intron|BTNL2_uc010jua.1_Intron	NM_019602	NP_062548	Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2	223	Ig-like V-type 2.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1						CAGTGAGGACGGGGTTGTGGA	0.587			NA											4	35					0	0	0.009096	0	0
COL11A2	1302	broad.mit.edu	37	6	33145200	33145200	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:33145200G>T	uc003ocx.1	-	23	2188	c.1960C>A	c.(1960-1962)CCT>ACT	p.P654T	COL11A2_uc010jul.1_Silent_p.P33P|COL11A2_uc003ocy.1_Missense_Mutation_p.P568T|COL11A2_uc003ocz.1_Missense_Mutation_p.P547T	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	654	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TGGGTCCCAGGGGTGCCCTGT	0.557	Melanoma(1;90 116 3946 5341 17093)		NA											15	36					1.67942e-08	1.97446e-08	0.006122	1	0
COL11A2	1302	broad.mit.edu	37	6	33157167	33157167	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:33157167A>G	uc003ocx.1	-	2	390	c.162T>C	c.(160-162)TGT>TGC	p.C54C	COL11A2_uc003ocy.1_Silent_p.C54C|COL11A2_uc003ocz.1_Silent_p.C54C|COL11A2_uc003oda.2_Silent_p.C54C	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	54	TSP N-terminal.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						CATCAGCTGGACAGATGCCTT	0.627	Melanoma(1;90 116 3946 5341 17093)		NA											49	21					0	0	0.00361	0	0
CLPS	1208	broad.mit.edu	37	6	35765033	35765033	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:35765033G>T	uc003ole.1	-	1	70	c.33C>A	c.(31-33)GCC>GCA	p.A11A	CLPS_uc003olf.1_Silent_p.A11A	NM_001832	NP_001823	P04118	COL_HUMAN	colipase preproprotein	11					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region					0						CCACAGAGAGGGCGACAAGCA	0.597	Melanoma(167;2962 3494 37796)		NA											15	126					3.52763e-06	3.90747e-06	0.00499	1	0
PXT1	222659	broad.mit.edu	37	6	36359620	36359620	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:36359620T>C	uc003omd.1	-	2	113	c.83A>G	c.(82-84)GAT>GGT	p.D28G		NM_152990	NP_694535	Q8NFP0	PXT1_HUMAN	peroxisomal, testis specific 1	28						peroxisome					0						GACAAAATGATCTAGTGCATC	0.343			NA											26	90					0	0	0.002096	0	0
BTBD9	114781	broad.mit.edu	37	6	38545399	38545399	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:38545399T>A	uc003ooa.3	-	7	1707	c.1131A>T	c.(1129-1131)TTA>TTT	p.L377F	BTBD9_uc003ony.3_Missense_Mutation_p.L309F|BTBD9_uc010jwv.2_Missense_Mutation_p.L309F|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.L377F	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	377					cell adhesion						0						CTGGAAAATATAATTTCTGCC	0.363			NA											56	40					0	0	0.00361	0	0
DNAH8	1769	broad.mit.edu	37	6	38738285	38738285	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:38738285G>T	uc003ooe.1	+	10	1663	c.1063G>T	c.(1063-1065)GAA>TAA	p.E355*		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TGAGGTTTCAGAAATGTATAT	0.363			NA											17	31					2.23348e-06	2.47965e-06	0.004007	1	0
DNAH8	1769	broad.mit.edu	37	6	38891824	38891824	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:38891824T>A	uc003ooe.1	+	71	10797	c.10197T>A	c.(10195-10197)AAT>AAA	p.N3399K	uc003oof.1_Intron	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTCCTTTCAATCAGATATTTA	0.418			NA											23	94					0	0	0.00333	0	0
LRFN2	57497	broad.mit.edu	37	6	40360088	40360088	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:40360088C>T	uc003oph.1	-	3	2429	c.1964G>A	c.(1963-1965)CGC>CAC	p.R655H		NM_020737	NP_065788	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III	655	Cytoplasmic (Potential).					cell junction|integral to membrane|postsynaptic membrane				ovary(2)|skin(1)	3	Ovarian(28;0.0418)|Colorectal(47;0.196)					CCCCATCAGGCGGTCAAGGCT	0.711			NA											5	10					0	0	0.001168	0	0
TRERF1	55809	broad.mit.edu	37	6	42225903	42225904	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:42225903_42225904CC>AA	uc003osd.2	-	10	2868_2869	c.2305_2306GG>TT	c.(2305-2307)GGG>TTG	p.G769L	TRERF1_uc011duq.1_Missense_Mutation_p.G686L|TRERF1_uc003osb.2_Missense_Mutation_p.G525L|TRERF1_uc003osc.2_Missense_Mutation_p.G525L|TRERF1_uc003ose.2_Missense_Mutation_p.G789L	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	769	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTCTCCAGGCCCTGGGGTGACC	0.421			NA											13	33					0	0	0.004672	0	0
ABCC10	89845	broad.mit.edu	37	6	43400872	43400872	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:43400872G>T	uc003ouy.1	+	3	1369	c.1154G>T	c.(1153-1155)GGC>GTC	p.G385V	ABCC10_uc003ouz.1_Missense_Mutation_p.G342V|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	385	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			AACCTACTAGGCACTGACTCT	0.607			NA											20	57					3.8784e-16	5.3122e-16	0.001882	1	0
SLC29A1	2030	broad.mit.edu	37	6	44199133	44199133	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:44199133G>C	uc003owu.1	+	9	1128	c.799G>C	c.(799-801)GGA>CGA	p.G267R	SLC29A1_uc003owv.1_Missense_Mutation_p.G267R|SLC29A1_uc003oww.1_Missense_Mutation_p.G346R|SLC29A1_uc003owx.1_Missense_Mutation_p.G267R|SLC29A1_uc003owy.1_Missense_Mutation_p.G267R|SLC29A1_uc003owz.1_Missense_Mutation_p.G267R	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1	267	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	AGAGGAATCTGGAGTTTCAGT	0.478			NA											5	4					0	0	0.001168	0	0
CDC5L	988	broad.mit.edu	37	6	44390392	44390392	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:44390392C>G	uc003oxl.2	+	10	1509	c.1250C>G	c.(1249-1251)TCT>TGT	p.S417C		NM_001253	NP_001244	Q99459	CDC5L_HUMAN	CDC5-like	417	Interaction with PPP1R8.				cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			lung(3)|ovary(1)|kidney(1)|skin(1)	6	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGGACTCCTTCTAATGGAGCT	0.408			NA											28	83					0	0	0.008361	0	0
TFAP2D	83741	broad.mit.edu	37	6	50712878	50712878	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:50712878C>A	uc003paf.2	+	6	1454	c.942C>A	c.(940-942)GCC>GCA	p.A314A	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	314	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					AGTTTCCAGCCAAAGCAGTAG	0.458			NA											27	21					6.32553e-13	8.11783e-13	0.004656	1	0
GSTA1	2938	broad.mit.edu	37	6	52659012	52659012	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:52659012G>A	uc003paz.2	-	5	437	c.325C>T	c.(325-327)CTG>TTG	p.L109L		NM_145740	NP_665683	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	109	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	CATACGGGCAGAAGGAGGATC	0.388			NA											50	132					0	0	0.00361	0	0
GSTA5	221357	broad.mit.edu	37	6	52697680	52697680	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:52697680T>A	uc003pba.1	-	6	593	c.523A>T	c.(523-525)ATC>TTC	p.I175F		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	175	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	AAGCTGGAGATAAGACTCGAG	0.522			NA											66	55					0	0	0.00361	0	0
C6orf142	90523	broad.mit.edu	37	6	53989559	53989559	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:53989559C>A	uc003pcg.3	+	3	621	c.508C>A	c.(508-510)CTG>ATG	p.L170M	C6orf142_uc003pcf.2_Missense_Mutation_p.L170M|C6orf142_uc003pch.3_Missense_Mutation_p.L108M|C6orf142_uc011dwz.1_Missense_Mutation_p.L129M|C6orf142_uc011dxa.1_Missense_Mutation_p.L181M	NM_138569	NP_612636	Q5VWP3	MLIP_HUMAN	hypothetical protein LOC90523	170						nuclear envelope|PML body	protein binding				0	Lung NSC(77;0.0317)					CTCGTCCAGTCTGGTCTCTGA	0.552			NA											18	49					3.52763e-06	3.90747e-06	0.00499	1	0
LGSN	51557	broad.mit.edu	37	6	63990034	63990034	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:63990034C>A	uc003peh.2	-	4	1456	c.1422G>T	c.(1420-1422)CAG>CAT	p.Q474H	LGSN_uc003pei.2_3'UTR	NM_016571	NP_057655	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase	474					glutamine biosynthetic process		glutamate-ammonia ligase activity			skin(2)	2					L-Glutamic Acid(DB00142)	CTCCTAGAGCCTGTCTCAGGC	0.393			NA											19	42					2.94398e-08	3.44236e-08	0.007413	1	0
COL19A1	1310	broad.mit.edu	37	6	70639585	70639585	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:70639585C>T	uc003pfc.1	+	6	776	c.659C>T	c.(658-660)CCT>CTT	p.P220L	COL19A1_uc010kam.1_Missense_Mutation_p.P116L	NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	220	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						GATGGCAAGCCTGTGGATGTA	0.348			NA											9	46					0	0	0.000978	0	0
COL19A1	1310	broad.mit.edu	37	6	70909428	70909428	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:70909428C>G	uc003pfc.1	+	49	3328	c.3211C>G	c.(3211-3213)CCT>GCT	p.P1071A		NM_001858	NP_001849	Q14993	COJA1_HUMAN	alpha 1 type XIX collagen precursor	1071	Triple-helical region 6 (COL6).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			ovary(2)|breast(2)	4						ACCAGGAGACCCTGGACCCCA	0.473			NA											49	18					0	0	0.00361	0	0
FAM135A	57579	broad.mit.edu	37	6	71235546	71235546	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:71235546C>G	uc003pfj.2	+	13	2892	c.2759C>G	c.(2758-2760)CCT>CGT	p.P920R	FAM135A_uc003pfi.2_Missense_Mutation_p.P724R|FAM135A_uc003pfh.2_Missense_Mutation_p.P707R|FAM135A_uc003pfl.2_Missense_Mutation_p.P587R|FAM135A_uc003pfn.2_Intron|FAM135A_uc003pfo.1_Missense_Mutation_p.P291R|FAM135A_uc010kan.1_5'Flank	NM_001162529	NP_001156001	Q9P2D6	F135A_HUMAN	hypothetical protein LOC57579 isoform c	920										central_nervous_system(1)	1						ATTAAAGACCCTTTACAATTT	0.368			NA											15	37					0	0	0.003163	0	0
SMAP1	60682	broad.mit.edu	37	6	71567637	71567637	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:71567637G>T	uc003pfr.2	+	10	1222	c.974G>T	c.(973-975)GGA>GTA	p.G325V	SMAP1_uc003pfs.2_Missense_Mutation_p.G298V|SMAP1_uc010kao.2_Missense_Mutation_p.G298V|SMAP1_uc010kap.2_Missense_Mutation_p.G315V	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	325					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						GTATTTATGGGACCCACAAAT	0.443			NA											37	26					4.90274e-10	5.9485e-10	0.00623	1	0
RIMS1	22999	broad.mit.edu	37	6	72806748	72806748	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:72806748G>T	uc003pga.2	+	3	419	c.342G>T	c.(340-342)CCG>CCT	p.P114P		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	114	RabBD.|FYVE-type.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				ACGATGCTCCGACTTGTGGAA	0.502			NA											25	10					5.35356e-11	6.63704e-11	0.00278	1	0
COL12A1	1303	broad.mit.edu	37	6	75861589	75861589	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:75861589C>G	uc003phs.2	-	20	4160	c.3994G>C	c.(3994-3996)GCT>CCT	p.A1332P	COL12A1_uc003pht.2_Missense_Mutation_p.A168P	NM_004370	NP_004361	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1 long isoform	1332	VWFA 3.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			ovary(6)|large_intestine(1)|breast(1)|skin(1)	9						GTACCAATAGCAAACAGCTCC	0.413			NA											73	48					0	0	0.00361	0	0
TBX18	9096	broad.mit.edu	37	6	85446925	85446925	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:85446925C>A	uc003pkl.1	-	8	1302	c.1302G>T	c.(1300-1302)TTG>TTT	p.L434F	TBX18_uc010kbq.1_Intron	NM_001080508	NP_001073977	O95935	TBX18_HUMAN	T-box 18	434					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|pancreas(2)|lung(1)	5		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		AGGTCTCTGCCAAAGATGTGC	0.607			NA											37	8					3.76114e-14	4.93825e-14	0.004289	1	0
GJB7	375519	broad.mit.edu	37	6	87993968	87993968	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:87993968G>T	uc003plo.2	-	3	1009	c.663C>A	c.(661-663)CTC>CTA	p.L221L		NM_198568	NP_940970	Q6PEY0	CXB7_HUMAN	gap junction protein, beta 7, 25kDa	221	Cytoplasmic (Potential).				cell communication	connexon complex|integral to membrane					0		all_cancers(76;1.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;7.38e-10)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00323)		BRCA - Breast invasive adenocarcinoma(108;0.0167)		CTCACACACTGAGGACTTGAG	0.423			NA											24	5					3.7963e-18	5.41449e-18	0.00333	1	0
MDN1	23195	broad.mit.edu	37	6	90460092	90460092	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:90460092C>T	uc003pnn.1	-	24	3503	c.3387G>A	c.(3385-3387)GGG>GGA	p.G1129G		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1129					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGACAAGCTTCCCTGAGGAGT	0.423			NA											93	16					0	0	0.00361	0	0
EPHA7	2045	broad.mit.edu	37	6	93956558	93956558	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:93956558A>G	uc003poe.2	-	15	2919	c.2678T>C	c.(2677-2679)ATG>ACG	p.M893T	EPHA7_uc003pof.2_Missense_Mutation_p.M888T|EPHA7_uc011eac.1_Missense_Mutation_p.M889T	NM_004440	NP_004431	Q15375	EPHA7_HUMAN	ephrin receptor EphA7 precursor	893	Cytoplasmic (Potential).|Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(8)|ovary(7)|upper_aerodigestive_tract(3)|central_nervous_system(3)|skin(3)|large_intestine(2)|stomach(1)|pancreas(1)	28		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		GTTTCGAATCATTTTGTCTAG	0.418			NA											38	12					0	0	0.006999	0	0
GRIK2	2898	broad.mit.edu	37	6	102069914	102069914	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:102069914C>A	uc003pqp.3	+	2	455	c.206C>A	c.(205-207)ACA>AAA	p.T69K	GRIK2_uc003pqn.2_Missense_Mutation_p.T69K|GRIK2_uc003pqo.3_Missense_Mutation_p.T69K|GRIK2_uc010kcw.2_Missense_Mutation_p.T69K	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	69	Extracellular (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	AGAAACAGAACATTGCTACCC	0.368			NA											31	11					4.74835e-14	6.22176e-14	0.002096	1	0
FOXO3	2309	broad.mit.edu	37	6	108984932	108984932	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:108984932G>T	uc003psk.2	+	3	1212	c.896G>T	c.(895-897)AGC>ATC	p.S299I	FOXO3_uc003psn.2_Intron|FOXO3_uc003psm.2_Missense_Mutation_p.S299I|FOXO3_uc011ean.1_Missense_Mutation_p.S79I|FOXO3_uc010kdj.1_Missense_Mutation_p.S79I	NM_201559	NP_963853	O43524	FOXO3_HUMAN	forkhead box O3A	299				PGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIMAS -> AWQPHVNAAVMSWMRGRTSVHAPILTPAQSVAACRPSW QV (in Ref. 5; CAA04860).	antral ovarian follicle growth|apoptosis|embryo development|glucose homeostasis|induction of apoptosis|initiation of primordial ovarian follicle growth|insulin receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|oocyte maturation|ovulation from ovarian follicle|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			central_nervous_system(4)|lung(2)	6		all_cancers(87;1.78e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;3.88e-05)|Colorectal(196;0.0294)|all_lung(197;0.0487)|Lung SC(18;0.152)		Epithelial(106;0.000759)|all cancers(137;0.00121)|BRCA - Breast invasive adenocarcinoma(108;0.00163)|OV - Ovarian serous cystadenocarcinoma(136;0.00718)		ACGTCACGCAGCAGTGATGAG	0.627			NA											22	4					1.22574e-08	1.44812e-08	0.002299	1	0
SLC22A16	85413	broad.mit.edu	37	6	110777975	110777975	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:110777975C>A	uc003puf.2	-	2	366	c.299G>T	c.(298-300)AGG>ATG	p.R100M	SLC22A16_uc003pue.2_Missense_Mutation_p.R81M|SLC22A16_uc003pug.2_Missense_Mutation_p.R100M	NM_033125	NP_149116	Q86VW1	S22AG_HUMAN	solute carrier family 22, member 16	100					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			ovary(1)	1		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		CCTGCTACACCTTGAGAGCTC	0.473			NA											134	34					1.67419e-43	2.99804e-43	0.00361	1	0
HS3ST5	222537	broad.mit.edu	37	6	114378639	114378639	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:114378639G>T	uc003pwg.3	-	2	855	c.823C>A	c.(823-825)CTG>ATG	p.L275M	uc003pwf.2_Intron|HS3ST5_uc003pwh.3_Missense_Mutation_p.L275M	NM_153612	NP_705840	Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine)	275	Lumenal (Potential).				heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			ovary(1)|pancreas(1)	2		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		CTTGGAGGCAGATTTAGGAAC	0.428			NA											30	11					8.88839e-20	1.30327e-19	0.002096	1	0
GPRC6A	222545	broad.mit.edu	37	6	117128190	117128190	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:117128190G>T	uc003pxj.1	-	3	700	c.678C>A	c.(676-678)AAC>AAA	p.N226K	GPRC6A_uc003pxk.1_Missense_Mutation_p.N226K|GPRC6A_uc003pxl.1_Missense_Mutation_p.N226K	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	226	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TTATAAAAGTGTTAAGAGCCA	0.393			NA											72	22					2.84776e-26	4.57439e-26	0.00361	1	0
RFX6	222546	broad.mit.edu	37	6	117239224	117239224	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:117239224G>T	uc003pxm.2	+	10	1060	c.997G>T	c.(997-999)GCA>TCA	p.A333S		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	333					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						ACTCATTCCTGCAACAATGCA	0.289			NA											24	43					1.75199e-13	2.26948e-13	0.007291	1	0
C6orf204	387119	broad.mit.edu	37	6	118886876	118886876	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:118886876A>G	uc003pxz.1	-	3	1424	c.836T>C	c.(835-837)ATG>ACG	p.M279T	C6orf204_uc003pya.1_Missense_Mutation_p.M282T|C6orf204_uc003pyb.2_Missense_Mutation_p.M279T|C6orf204_uc011ebj.1_Missense_Mutation_p.M177T|C6orf204_uc003pyc.2_Missense_Mutation_p.M282T|C6orf204_uc011ebl.1_Missense_Mutation_p.M177T	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	279						centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTGACCAAGCATTAAATATTT	0.463			NA											18	20					0	0	0.00499	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130415511	130415511	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:130415511A>T	uc003qbt.2	+	18	1905	c.1735A>T	c.(1735-1737)AGT>TGT	p.S579C	L3MBTL3_uc003qbu.2_Missense_Mutation_p.S554C	NM_032438	NP_115814	Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 isoform a	579					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		GGGCCCTCACAGGTATGTGGT	0.403			NA											33	2					0	0	0.002836	0	0
MAP7	9053	broad.mit.edu	37	6	136687148	136687148	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:136687148G>A	uc003qgz.2	-	10	1244	c.998C>T	c.(997-999)TCC>TTC	p.S333F	MAP7_uc011edf.1_Missense_Mutation_p.S318F|MAP7_uc011edg.1_Missense_Mutation_p.S363F|MAP7_uc010kgu.2_Missense_Mutation_p.S355F|MAP7_uc011edh.1_Missense_Mutation_p.S318F|MAP7_uc010kgv.2_Missense_Mutation_p.S355F|MAP7_uc010kgs.2_Missense_Mutation_p.S187F|MAP7_uc011edi.1_Missense_Mutation_p.S187F|MAP7_uc010kgq.1_Missense_Mutation_p.S239F|MAP7_uc003qha.1_Missense_Mutation_p.S296F|MAP7_uc010kgr.2_Missense_Mutation_p.S187F	NM_003980	NP_003971	Q14244	MAP7_HUMAN	microtubule-associated protein 7	333	Pro-rich.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AAGAGACTTGGACGGAAGCCT	0.572			NA											21	7					0	0	0.008871	0	0
IFNGR1	3459	broad.mit.edu	37	6	137519525	137519525	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:137519525C>G	uc003qho.2	-	7	1216	c.1113G>C	c.(1111-1113)CTG>CTC	p.L371L	IFNGR1_uc011edm.1_Silent_p.L343L	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	371	Cytoplasmic (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	CTATTGGAGTCAGATGGCTGC	0.428			NA											31	73					0	0	0.002445	0	0
CCDC28A	25901	broad.mit.edu	37	6	139094885	139094885	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:139094885T>A	uc003qie.2	+	1	229	c.74T>A	c.(73-75)CTG>CAG	p.L25Q	uc003qid.1_5'Flank	NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	25											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		GCATGGAGGCTGTACCTCTTA	0.622			NA											109	36					0	0	0.00361	0	0
REPS1	85021	broad.mit.edu	37	6	139226204	139226204	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:139226204T>C	uc003qii.2	-	20	2967	c.2388A>G	c.(2386-2388)CTA>CTG	p.L796L	REPS1_uc003qig.3_Silent_p.L769L|REPS1_uc011edr.1_Silent_p.L795L|REPS1_uc003qij.2_Silent_p.L705L|REPS1_uc003qik.2_Silent_p.L402L	NM_031922	NP_114128	Q96D71	REPS1_HUMAN	RALBP1 associated Eps domain containing 1	796	Interaction with RALBP1 (By similarity).					coated pit|plasma membrane	calcium ion binding|SH3 domain binding			lung(1)|breast(1)	2				GBM - Glioblastoma multiforme(68;0.000434)|OV - Ovarian serous cystadenocarcinoma(155;0.000548)		AATTGGCTTATAGGTGAGAGA	0.398			NA											13	5					0	0	0.001855	0	0
SASH1	23328	broad.mit.edu	37	6	148852668	148852668	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:148852668G>T	uc003qme.1	+	13	1910	c.1435G>T	c.(1435-1437)GGC>TGC	p.G479C	SASH1_uc011eeb.1_Missense_Mutation_p.G240C|SASH1_uc003qmf.1_Intron	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	479							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		GCAGGACTCGGGCCTTGATGG	0.522			NA											43	7					2.01872e-29	3.34263e-29	0.00361	1	0
TIAM2	26230	broad.mit.edu	37	6	155498024	155498024	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:155498024T>C	uc003qqb.2	+	12	3709	c.2436T>C	c.(2434-2436)ACT>ACC	p.T812T	TIAM2_uc003qqe.2_Silent_p.T812T|TIAM2_uc010kjj.2_Silent_p.T345T|TIAM2_uc003qqf.2_Silent_p.T188T|TIAM2_uc011efl.1_Silent_p.T148T|TIAM2_uc003qqg.2_Silent_p.T124T	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	812	RBD.				apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		AAATCCAGACTTATGTCCACT	0.428			NA											23	17					0	0	0.00278	0	0
Unknown	0	broad.mit.edu	37	6	160183048	160183048	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:160183048C>A	uc003qsp.2	-	1	317	c.122G>T	c.(121-123)GGC>GTC	p.G41V	ACAT2_uc010kjy.2_5'UTR|ACAT2_uc011efw.1_5'Flank					Homo sapiens cDNA clone IMAGE:5287966.												NA						CCGCGGCAGGCCTGTGGGCTG	0.667			NA											11	1					9.70103e-10	1.17042e-09	0.008291	1	0
PLG	5340	broad.mit.edu	37	6	161173271	161173271	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:161173271C>T	uc003qtm.3	+	18	2313	c.2250C>T	c.(2248-2250)GCC>GCT	p.A750A		NM_000301	NP_000292	P00747	PLMN_HUMAN	plasminogen	750	Peptidase S1.				extracellular matrix disassembly|fibrinolysis|negative regulation of cell proliferation|negative regulation of cell-substrate adhesion|negative regulation of fibrinolysis|platelet activation|platelet degranulation|positive regulation of fibrinolysis|proteolysis|tissue remodeling	extracellular space|extrinsic to external side of plasma membrane|platelet alpha granule lumen	apolipoprotein binding|cell surface binding|serine-type endopeptidase activity	p.A750V(1)		skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(65;5.24e-17)|BRCA - Breast invasive adenocarcinoma(81;7.08e-06)	Aminocaproic Acid(DB00513)|Streptokinase(DB00086)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	GGCATTTGGCCGGAGGCACTG	0.502			NA											19	35					0	0	0.007413	0	0
PARK2	5071	broad.mit.edu	37	6	161970005	161970005	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:161970005C>A	uc003qtx.3	-	9	1098	c.964G>T	c.(964-966)GAG>TAG	p.E322*	PARK2_uc003qtv.3_Intron|PARK2_uc010kkd.2_Nonsense_Mutation_p.E131*|PARK2_uc003qtw.3_Nonsense_Mutation_p.E131*|PARK2_uc003qty.3_Nonsense_Mutation_p.E294*|PARK2_uc003qtz.3_Nonsense_Mutation_p.E173*|PARK2_uc010kke.1_Nonsense_Mutation_p.E341*|PARK2_uc011egf.1_5'UTR	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	322	IBR-type.				aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		AGGACACACTCCTCTGCACCA	0.572			NA											14	37					9.05144e-12	1.14042e-11	0.001855	1	0
TTLL2	83887	broad.mit.edu	37	6	167754848	167754848	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:167754848A>C	uc003qvs.1	+	3	1548	c.1460A>C	c.(1459-1461)CAG>CCG	p.Q487P	TTLL2_uc011egr.1_RNA	NM_031949	NP_114155	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	487					protein modification process		ATP binding|tubulin-tyrosine ligase activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CCTGCCTCCCAGCTGGAAGGA	0.517			NA											17	27					0	0	0.00499	0	0
WDR27	253769	broad.mit.edu	37	6	170033143	170033143	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:170033143C>T	uc003qwx.2	-	21	2643	c.2123G>A	c.(2122-2124)CGG>CAG	p.R708Q	WDR27_uc003qwv.1_RNA|WDR27_uc010kkw.1_Missense_Mutation_p.R708Q|WDR27_uc003qwy.2_Missense_Mutation_p.R581Q			A2RRH5	WDR27_HUMAN	RecName: Full=WD repeat-containing protein 27;	678	WD 7.									pancreas(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GGTCCTGTTCCGGCCAGCTGC	0.522			NA											15	2					0	0	0.003163	0	0
INTS1	26173	broad.mit.edu	37	7	1523719	1523719	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:1523719G>A	uc003skn.2	-	25	3450	c.3349C>T	c.(3349-3351)CTG>TTG	p.L1117L	INTS1_uc003skp.1_Silent_p.L464L	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1117					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGAGCGCTCAGCACGGCGTCC	0.652			NA											69	8					0	0	0.00361	0	0
SDK1	221935	broad.mit.edu	37	7	3991467	3991467	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:3991467G>T	uc003smx.2	+	7	1204	c.1065G>T	c.(1063-1065)GCG>GCT	p.A355A		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	355	Ig-like C2-type 3.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CGACGTCCGCGGACACCGGGC	0.612			NA											45	10					1.00776e-21	1.52623e-21	0.00361	1	0
SDK1	221935	broad.mit.edu	37	7	4249774	4249774	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:4249774A>T	uc003smx.2	+	38	5658	c.5519A>T	c.(5518-5520)GAG>GTG	p.E1840V	SDK1_uc010kso.2_Missense_Mutation_p.E1096V|SDK1_uc003smy.2_Missense_Mutation_p.E327V	NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	1840	Fibronectin type-III 12.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GTGGTGTACGAGCCCTTGGCC	0.642			NA											37	4					0	0	0.004289	0	0
MEOX2	4223	broad.mit.edu	37	7	15725606	15725606	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:15725606C>T	uc003stc.2	-	1	703	c.422G>A	c.(421-423)GGG>GAG	p.G141E	MEOX2_uc011jxw.1_Missense_Mutation_p.G141E	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	141					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		GCACGCGGCCCCAGTCGGGGT	0.697	Esophageal Squamous(140;197 1769 16409 18257 29929)		NA											75	34					0	0	0.00361	0	0
HDAC9	9734	broad.mit.edu	37	7	19015535	19015535	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:19015535A>T	uc003sui.2	+	24	3170	c.3129A>T	c.(3127-3129)CTA>CTT	p.L1043L	HDAC9_uc003sue.2_Silent_p.L1040L|HDAC9_uc003suj.2_Silent_p.L999L|HDAC9_uc003suk.2_Silent_p.L288L	NM_178425	NP_848512	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 5	Error:Variant_position_missing_in_Q9UKV0_after_alignment					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	TGGCCTCCCTAACAGTGGATG	0.537			NA											30	19					0	0	0.009535	0	0
ABCB5	340273	broad.mit.edu	37	7	20782625	20782625	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:20782625G>A	uc003suw.3	+	16	2361	c.1815G>A	c.(1813-1815)GGG>GGA	p.G605G	ABCB5_uc010kuh.2_Silent_p.G1050G	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	605	ATP (Potential).|Cytoplasmic (Potential).|ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						CATTTGTGGGGAGCAGCGGCT	0.478			NA											13	37					0	0	0.001368	0	0
DNAH11	8701	broad.mit.edu	37	7	21784174	21784174	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:21784174T>A	uc003svc.2	+	51	8325	c.8294T>A	c.(8293-8295)TTG>TAG	p.L2765*		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2765					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						GATTGTGATTTGTTTCAGAGA	0.378			NA							Kartagener_syndrome				40	106					0	0	0.00623	0	0
DNAH11	8701	broad.mit.edu	37	7	21827194	21827194	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:21827194T>A	uc003svc.2	+	61	9969	c.9938T>A	c.(9937-9939)TTC>TAC	p.F3313Y		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3313	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						ATCATTAAATTCTATGAGGTA	0.388			NA							Kartagener_syndrome				15	11					0	0	0.003163	0	0
DNAH11	8701	broad.mit.edu	37	7	21901563	21901563	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:21901563C>G	uc003svc.2	+	70	11347	c.11316C>G	c.(11314-11316)ACC>ACG	p.T3772T		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3772					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGAGCATCACCCATGCTGTCT	0.517			NA							Kartagener_syndrome				10	30					0	0	0.008291	0	0
CREB5	9586	broad.mit.edu	37	7	28857757	28857757	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:28857757C>A	uc003szq.2	+	10	1714	c.1324C>A	c.(1324-1326)CCA>ACA	p.P442T	CREB5_uc003szo.2_Missense_Mutation_p.P409T|CREB5_uc003szr.2_Missense_Mutation_p.P435T|CREB5_uc003szs.2_Missense_Mutation_p.P303T	NM_182898	NP_878901	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	442					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)	2						TAAAGACTGCCCAATAACAGC	0.358			NA											62	37					7.577e-32	1.28094e-31	0.00361	1	0
CHN2	1124	broad.mit.edu	37	7	29539621	29539621	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:29539621T>A	uc003szz.2	+	9	1315	c.878T>A	c.(877-879)GTG>GAG	p.V293E	CHN2_uc011jzs.1_Missense_Mutation_p.V368E|CHN2_uc010kva.2_Missense_Mutation_p.V63E|CHN2_uc010kvb.2_Intron|CHN2_uc010kvc.2_Missense_Mutation_p.V258E|CHN2_uc011jzt.1_Missense_Mutation_p.V306E|CHN2_uc010kvd.2_Missense_Mutation_p.V149E|CHN2_uc011jzu.1_Missense_Mutation_p.V278E|CHN2_uc010kvg.2_Missense_Mutation_p.V157E|CHN2_uc010kvh.2_Intron|CHN2_uc010kvi.2_Missense_Mutation_p.V157E|CHN2_uc010kve.2_Missense_Mutation_p.V157E|CHN2_uc003taa.2_Missense_Mutation_p.V157E|CHN2_uc010kvf.2_Intron|CHN2_uc010kvj.2_Missense_Mutation_p.V112E|CHN2_uc010kvk.2_Intron|CHN2_uc010kvl.2_RNA|CHN2_uc010kvm.2_Missense_Mutation_p.V112E|CHN2_uc011jzv.1_Missense_Mutation_p.V86E	NM_004067	NP_004058	P52757	CHIO_HUMAN	beta chimerin isoform 2	293	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|membrane	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(2)	2						AGACCCATGGTGGTAGACATA	0.383	Ovarian(1;44 48 13232 18918 31480)		NA											12	39					0	0	0.000978	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31123758	31123758	+	Missense_Mutation	SNP	A	A	G	rs138870097		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:31123758A>G	uc003tca.1	+	7	554	c.331A>G	c.(331-333)ATG>GTG	p.M111V	ADCYAP1R1_uc003tcb.1_Missense_Mutation_p.M90V|ADCYAP1R1_uc003tcc.1_Missense_Mutation_p.M111V|ADCYAP1R1_uc003tcd.1_Missense_Mutation_p.M111V|ADCYAP1R1_uc003tce.1_Missense_Mutation_p.M111V|ADCYAP1R1_uc003tcf.1_5'Flank	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	111	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						TGCTGCAGACATGGGAGTGGT	0.473	Ovarian(44;225 1186 2158 11092)		NA											68	26					0	0	0.00361	0	0
BMPER	168667	broad.mit.edu	37	7	34091553	34091553	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:34091553T>A	uc011kap.1	+	8	871	c.757T>A	c.(757-759)TAC>AAC	p.Y253N		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	253	VWFC 4.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CTCATTTCTGTACGATAACTG	0.473			NA											99	58					0	0	0.00361	0	0
ANLN	54443	broad.mit.edu	37	7	36438687	36438687	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:36438687G>T	uc003tff.2	+	3	377	c.173_splice	c.e3-1	p.E58_splice	ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Splice_Site_p.E58_splice|ANLN_uc010kxe.2_Splice_Site_p.E58_splice	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein						cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TTTTAATGTAGAGAAATCTTG	0.338			NA											15	37					1.3612e-06	1.52348e-06	0.003163	1	0
TXNDC3	51314	broad.mit.edu	37	7	37928015	37928015	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:37928015A>G	uc003tfn.2	+	15	1756	c.1384A>G	c.(1384-1386)ACA>GCA	p.T462A		NM_016616	NP_057700	Q8N427	TXND3_HUMAN	thioredoxin domain containing 3	462	NDK 3.				cell differentiation|cell redox homeostasis|CTP biosynthetic process|GTP biosynthetic process|multicellular organismal development|spermatogenesis|UTP biosynthetic process	cytoplasm|microtubule cytoskeleton	ATP binding|nucleoside diphosphate kinase activity			ovary(1)|breast(1)|central_nervous_system(1)	3						ACCTCATGCAACAAGTGAACA	0.318	Ovarian(108;903 1537 27096 29907 47400)		NA							Kartagener_syndrome				9	20					0	0	0.006214	0	0
INHBA	3624	broad.mit.edu	37	7	41730103	41730103	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:41730103C>A	uc003thq.2	-	2	661	c.426G>T	c.(424-426)AAG>AAT	p.K142N	INHBA_uc003thr.2_Missense_Mutation_p.K142N	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	142					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						CACTGCCTTCCTTGGAAATCT	0.502			NA								TSP Lung(11;0.080)			17	31					3.41278e-10	4.16424e-10	0.00499	1	0
HECW1	23072	broad.mit.edu	37	7	43484767	43484767	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:43484767G>A	uc003tid.1	+	11	2601	c.1996G>A	c.(1996-1998)GGG>AGG	p.G666R	HECW1_uc011kbi.1_Missense_Mutation_p.G666R	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1	666					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						CAGGCAAGGCGGGGACCACAG	0.692			NA											29	17					0	0	0.008361	0	0
URGCP	55665	broad.mit.edu	37	7	43918044	43918044	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:43918044C>T	uc003tiw.2	-	6	1075	c.1018G>A	c.(1018-1020)GAC>AAC	p.D340N	URGCP_uc003tiu.2_Missense_Mutation_p.D297N|URGCP_uc003tiv.2_Missense_Mutation_p.D265N|URGCP_uc003tix.2_Missense_Mutation_p.D331N|URGCP_uc003tiy.2_Missense_Mutation_p.D297N|URGCP_uc003tiz.2_Missense_Mutation_p.D297N|URGCP_uc011kbj.1_Missense_Mutation_p.D297N	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	340					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						GACCCGATGTCACCTCTCAGG	0.453			NA											20	73					0	0	0.001882	0	0
PGAM2	5224	broad.mit.edu	37	7	44105093	44105093	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:44105093G>C	uc003tjs.2	-	1	71	c.36C>G	c.(34-36)GGC>GGG	p.G12G		NM_000290	NP_000281	P15259	PGAM2_HUMAN	phosphoglycerate mutase 2	12					gluconeogenesis|glycolysis|striated muscle contraction	cytosol	2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity				0						ATGTGCTCTCGCCGTGCCGGA	0.622			NA											22	73					0	0	0.00278	0	0
PKD1L1	168507	broad.mit.edu	37	7	47874766	47874766	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:47874766C>A	uc003tny.1	-	38	6019	c.6019G>T	c.(6019-6021)GCC>TCC	p.A2007S		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2007	Helical; (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						AAGAGCTGGGCCCCTGGAGAA	0.602			NA											18	38					2.4624e-09	2.94878e-09	0.008871	1	0
ABCA13	154664	broad.mit.edu	37	7	48443368	48443368	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:48443368A>T	uc003toq.2	+	39	11987	c.11962A>T	c.(11962-11964)ATT>TTT	p.I3988F	ABCA13_uc010kys.1_Missense_Mutation_p.I1062F|ABCA13_uc003tos.1_Missense_Mutation_p.I814F|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3988	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CTCCCTTGGCATTGCTTTCAT	0.537			NA											13	32					0	0	0.001368	0	0
ABCA13	154664	broad.mit.edu	37	7	48443404	48443404	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:48443404G>C	uc003toq.2	+	39	12023	c.11998G>C	c.(11998-12000)GAT>CAT	p.D4000H	ABCA13_uc010kys.1_Missense_Mutation_p.D1074H|ABCA13_uc003tos.1_Missense_Mutation_p.D826H|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4000	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						CGTGGTTCTGGATGAGCCCAC	0.577			NA											21	15					0	0	0.001882	0	0
COBL	23242	broad.mit.edu	37	7	51094361	51094361	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:51094361G>A	uc003tpr.3	-	11	3571	c.3386C>T	c.(3385-3387)ACG>ATG	p.T1129M	COBL_uc003tps.2_Missense_Mutation_p.T1186M|COBL_uc011kcl.1_Missense_Mutation_p.T1129M|COBL_uc003tpp.3_Missense_Mutation_p.T915M|COBL_uc003tpq.3_Missense_Mutation_p.T1070M|COBL_uc003tpo.3_Missense_Mutation_p.T671M	NM_015198	NP_056013	O75128	COBL_HUMAN	cordon-bleu homolog	1129	WH2 1.									skin(3)|ovary(2)	5	Glioma(55;0.08)					GTGTTCTGCCGTCTAGAATAT	0.507	NSCLC(189;2119 2138 12223 30818 34679)		NA											14	242					0	0	0.00499	0	0
EGFR	1956	broad.mit.edu	37	7	55225444	55225444	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:55225444A>T	uc003tqk.2	+	11	1542	c.1296A>T	c.(1294-1296)CAA>CAT	p.Q432H	EGFR_uc003tqi.2_Missense_Mutation_p.Q432H|EGFR_uc003tqj.2_Missense_Mutation_p.Q432H|EGFR_uc010kzg.1_Missense_Mutation_p.Q387H|EGFR_uc011kco.1_Missense_Mutation_p.Q379H|EGFR_uc011kcp.1_RNA|EGFR_uc011kcq.1_RNA	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	432	Approximate.|Extracellular (Potential).				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GGACCAAGCAACAGTAAGTTG	0.338			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			35	71					0	0	0.004878	0	0
EGFR	1956	broad.mit.edu	37	7	55242491	55242491	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:55242491A>T	uc003tqk.2	+	19	2507	c.2261A>T	c.(2260-2262)AAA>ATA	p.K754I	EGFR_uc010kzg.1_Missense_Mutation_p.K709I|EGFR_uc011kco.1_Missense_Mutation_p.K701I	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	754	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S752_I759del(15)|p.T751_I759>N(8)|p.T751_I759>S(3)|p.A750_E758>P(3)|p.A750_K757del(2)|p.K754E(2)|p.A750_E758del(2)|p.T751_I759>NKA(2)|p.E749_E758>QP(2)|p.T751_E758del(2)|p.L747_K754>ST(1)|p.L747_N756>SKDD(1)|p.T751_E758>A(1)|p.T751_I759>REA(1)|p.L747_A755del(1)|p.P753_I759del(1)|p.K754R(1)|p.K754K(1)|p.K754A(1)|p.L747_K754>N(1)|p.A750_K754del(1)|p.L747_K754del(1)|p.L747_K754>GC(1)|p.S752_V769del(1)|p.L747_A755>SKS(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ACATCTCCGAAAGCCAACAAG	0.493			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			36	46					0	0	0.003755	0	0
EGFR	1956	broad.mit.edu	37	7	55266410	55266410	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:55266410G>T	uc003tqk.2	+	23	2948	c.2702G>T	c.(2701-2703)GGG>GTG	p.G901V	EGFR_uc010kzg.1_Missense_Mutation_p.G856V|EGFR_uc011kco.1_Missense_Mutation_p.G848V	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	901	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	ATCCTCTCAGGGGTGACTGTT	0.468			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			20	188					3.83957e-06	4.24813e-06	0.00278	1	0
FKBP9L	360132	broad.mit.edu	37	7	55750498	55750498	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:55750498G>T	uc010kzl.2	-	6	706	c.606C>A	c.(604-606)GCC>GCA	p.A202A	FKBP9L_uc010kzk.2_Silent_p.A91A|FKBP9L_uc003tqt.2_Silent_p.A91A|FKBP9L_uc011kcs.1_Silent_p.A91A	NR_003949				SubName: Full=cDNA, FLJ79189, highly similar to FK506-binding protein 9 (EC 5.2.1.8);												0						ATGCCACCTGGGCGTGAATGT	0.532			NA											39	69					6.60958e-23	1.01694e-22	0.00361	1	0
SEPT14	346288	broad.mit.edu	37	7	55902167	55902168	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:55902167_55902168TG>CT	uc003tqz.2	-	6	787_788	c.670_671CA>AG	c.(670-672)CAG>AGG	p.Q224R		NM_207366	NP_997249	Q6ZU15	SEP14_HUMAN	septin 14	224					cell cycle|cell division	septin complex	GTP binding|protein binding				0	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGTTGGGAGCTGATATATCTGG	0.371			NA											23	23					0	0	0.004672	0	0
WBSCR17	64409	broad.mit.edu	37	7	70880959	70880959	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:70880959G>T	uc003tvy.2	+	4	674	c.674G>T	c.(673-675)GGC>GTC	p.G225V	WBSCR17_uc003tvz.2_5'UTR	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	225	Catalytic subdomain A.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				AAGAGGGAAGGCCTGATCCGC	0.562			NA											11	8					0.00829132	0.00850685	0.008291	1	0
GNAT3	346562	broad.mit.edu	37	7	80091604	80091604	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:80091604G>C	uc011kgu.1	-	7	745	c.745C>G	c.(745-747)CTG>GTG	p.L249V	CD36_uc003uhc.2_Intron	NM_001102386	NP_001095856	A8MTJ3	GNAT3_HUMAN	guanine nucleotide binding protein, alpha	249					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|rhodopsin mediated phototransduction|sensory perception of sweet taste|sensory perception of umami taste	cytoplasm|heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						CTGTTGAACAGGTGAAGGCTT	0.353			NA											2	2					0	0	0.004672	0	0
ZNF804B	219578	broad.mit.edu	37	7	88963186	88963186	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:88963186C>A	uc011khi.1	+	4	1428	c.890C>A	c.(889-891)TCC>TAC	p.S297Y		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	297						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AATACCATCTCCATAAACTCT	0.353			NA								HNSCC(36;0.09)			23	9					4.26978e-12	5.40075e-12	0.00333	1	0
ZNF804B	219578	broad.mit.edu	37	7	88963308	88963308	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:88963308C>A	uc011khi.1	+	4	1550	c.1012C>A	c.(1012-1014)CCT>ACT	p.P338T		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	338						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGATTTTACTCCTACCAGCAG	0.358			NA								HNSCC(36;0.09)			29	7					3.65163e-15	4.918e-15	0.00632	1	0
SAMD9	54809	broad.mit.edu	37	7	92730661	92730661	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:92730661A>T	uc003umf.2	-	3	5006	c.4750T>A	c.(4750-4752)TAT>AAT	p.Y1584N	SAMD9_uc003umg.2_Missense_Mutation_p.Y1584N	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1584						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCAATGTCATAAGCAAGTGGG	0.388			NA											85	20					0	0	0.00361	0	0
SAMD9	54809	broad.mit.edu	37	7	92734566	92734566	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:92734566T>A	uc003umf.2	-	3	1101	c.845A>T	c.(844-846)AAG>ATG	p.K282M	SAMD9_uc003umg.2_Missense_Mutation_p.K282M	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	282						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCGAATGCACTTCTTTGCTTG	0.378			NA											47	5					0	0	0.003214	0	0
CCDC132	55610	broad.mit.edu	37	7	92905512	92905512	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:92905512A>T	uc003umo.2	+	12	965	c.837A>T	c.(835-837)CAA>CAT	p.Q279H	CCDC132_uc003umq.2_RNA|CCDC132_uc003ump.2_Missense_Mutation_p.Q249H|CCDC132_uc003umr.2_RNA|CCDC132_uc011khz.1_Intron|CCDC132_uc003umn.2_Missense_Mutation_p.Q279H	NM_017667	NP_060137	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132 isoform a	279											0	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			ACTTCACCCAAGCCATTCACA	0.343			NA											58	15					0	0	0.00361	0	0
SLC25A13	10165	broad.mit.edu	37	7	95906644	95906644	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:95906644T>C	uc003uof.3	-	3	267	c.76A>G	c.(76-78)AGC>GGC	p.S26G	SLC25A13_uc003uog.3_Missense_Mutation_p.S26G|SLC25A13_uc011kik.1_5'UTR	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	26					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	TTCTCAATGCTTGCATACTGT	0.313			NA											12	0					0	0	0.001368	0	0
TAC1	6863	broad.mit.edu	37	7	97361940	97361940	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:97361940G>T	uc003uop.3	+	2	262	c.16G>T	c.(16-18)GCC>TCC	p.A6S	TAC1_uc003uoq.3_Missense_Mutation_p.A6S|TAC1_uc003uor.3_Missense_Mutation_p.A6S|TAC1_uc003uos.3_Missense_Mutation_p.A6S	NM_003182	NP_003173	P20366	TKN1_HUMAN	tachykinin 1 isoform beta precursor	6					detection of abiotic stimulus|elevation of cytosolic calcium ion concentration|insemination|neuropeptide signaling pathway|synaptic transmission|tachykinin receptor signaling pathway	extracellular space					0	all_cancers(62;3.95e-09)|all_epithelial(64;1.1e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0358)|all_lung(186;0.0384)				Bacitracin(DB00626)	AATCCTCGTGGCCTTGGCAGT	0.443			NA											106	16					2.68928e-46	4.8382e-46	0.00361	1	0
BAIAP2L1	55971	broad.mit.edu	37	7	97991678	97991678	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:97991678C>T	uc003upj.2	-	2	381	c.118G>A	c.(118-120)GCT>ACT	p.A40T		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	40	IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			CCGTTTACAGCTTTCTCATAA	0.284			NA											33	6					0	0	0.003755	0	0
TRRAP	8295	broad.mit.edu	37	7	98562303	98562303	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:98562303A>T	uc003upp.2	+	47	7069	c.6860A>T	c.(6859-6861)GAC>GTC	p.D2287V	TRRAP_uc011kis.1_Missense_Mutation_p.D2269V|TRRAP_uc003upr.2_Missense_Mutation_p.D1986V	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2287	Interaction with TP53.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGCTACATAGACAGGCTGATC	0.502			NA											59	9					0	0	0.00361	0	0
MUC17	140453	broad.mit.edu	37	7	100686953	100686953	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:100686953C>A	uc003uxp.1	+	3	12309	c.12256C>A	c.(12256-12258)CCT>ACT	p.P4086T	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4086	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GACTGTGAACCCTGAGGCTGT	0.557			NA											87	15					2.33925e-33	3.99303e-33	0.00361	1	0
PIK3CG	5294	broad.mit.edu	37	7	106508261	106508261	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:106508261G>C	uc003vdv.3	+	2	340	c.255G>C	c.(253-255)GCG>GCC	p.A85A	PIK3CG_uc003vdu.2_Silent_p.A85A|PIK3CG_uc003vdw.2_Silent_p.A85A	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	85					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GCGTGGCGGCGGACTTCTACC	0.637			NA											29	10					0	0	0.009535	0	0
COG5	10466	broad.mit.edu	37	7	107002814	107002814	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:107002814C>A	uc003ved.2	-	9	1505	c.980G>T	c.(979-981)CGT>CTT	p.R327L	COG5_uc003vec.2_Missense_Mutation_p.R327L|COG5_uc003vee.2_Missense_Mutation_p.R327L	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	327					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						GAATGAGGCACGCAAAGCTGC	0.388			NA											28	3					2.42023e-17	3.39676e-17	0.003271	1	0
EIF3IP1	442720	broad.mit.edu	37	7	109599911	109599911	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:109599911C>A	uc003vfp.1	-	1	360	c.187G>T	c.(187-189)GAG>TAG	p.E63*		NR_003024				Homo sapiens eukaryotic translation initiation factor 3, subunit I pseudogene 1 (EIF3IP1), non-coding RNA.												0						TTCTGCTTCTCCATGGAGAAC	0.483			NA											12	16					6.40141e-05	6.88944e-05	0.000978	1	0
FOXP2	93986	broad.mit.edu	37	7	114269983	114269983	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:114269983C>G	uc003vhb.2	+	5	894	c.520C>G	c.(520-522)CAA>GAA	p.Q174E	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.Q199E|FOXP2_uc003vha.2_Missense_Mutation_p.Q82E|FOXP2_uc011kmu.1_Missense_Mutation_p.Q191E|FOXP2_uc011kmv.1_Missense_Mutation_p.Q174E|FOXP2_uc010ljz.1_Missense_Mutation_p.Q82E|FOXP2_uc003vgt.1_RNA|FOXP2_uc003vgv.1_Missense_Mutation_p.Q174E|FOXP2_uc003vgx.2_Missense_Mutation_p.Q174E|FOXP2_uc003vhd.2_Missense_Mutation_p.Q174E|FOXP2_uc003vhc.2_Missense_Mutation_p.Q199E	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	174	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q174*(1)		ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						acaacaacaacaacagcagca	0.169			NA											18	5					0	0	0.00499	0	0
ST7	7982	broad.mit.edu	37	7	116869933	116869933	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:116869933A>C	uc011knn.1	+	14	1465	c.1460A>C	c.(1459-1461)CAC>CCC	p.H487P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		TCCTCCACTCACCTCACCCGC	0.522			NA											6	46					0	0	0.003163	0	0
ANKRD7	56311	broad.mit.edu	37	7	117876982	117876982	+	Splice_Site	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:117876982T>A	uc003vji.2	+	5	885	c.712_splice	c.e5+2	p.H238_splice		NM_019644	NP_062618	Q92527	ANKR7_HUMAN	ankyrin repeat domain 7						male gonad development						0						TTTTACTGCGTAAGTGATACT	0.398			NA											94	17					0	0	0.00361	0	0
C7orf58	79974	broad.mit.edu	37	7	120935540	120935540	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:120935540A>T	uc003vjq.3	+	23	3362	c.2915A>T	c.(2914-2916)AAA>ATA	p.K972I		NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	972						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					ATTAAAATGAAAAGATCAAGA	0.328			NA											15	1					0	0	0.003163	0	0
GRM8	2918	broad.mit.edu	37	7	126409993	126409993	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:126409993A>G	uc003vlr.2	-	6	1594	c.1283T>C	c.(1282-1284)ATT>ACT	p.I428T	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.I428T|GRM8_uc010lkz.1_RNA|GRM8_uc003vlu.1_Missense_Mutation_p.I149T	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	428	Extracellular (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	ACAAAGGCCAATGTATCCAGG	0.408			NA								HNSCC(24;0.065)			35	33					0	0	0.004289	0	0
ZNF800	168850	broad.mit.edu	37	7	127014753	127014753	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:127014753C>A	uc003vlx.1	-	5	900	c.637G>T	c.(637-639)GAG>TAG	p.E213*	ZNF800_uc003vlw.1_Nonsense_Mutation_p.E116*|ZNF800_uc003vly.1_Nonsense_Mutation_p.E213*|ZNF800_uc010lla.2_Nonsense_Mutation_p.E213*	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GCCTGCGACTCCTGAGGTTGT	0.433			NA											54	56					1.46357e-32	2.48949e-32	0.00361	1	0
SND1	27044	broad.mit.edu	37	7	127729610	127729610	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:127729610G>T	uc003vmi.2	+	22	2714	c.2488G>T	c.(2488-2490)GTG>TTG	p.V830L	SND1_uc010lle.2_Missense_Mutation_p.V483L	NM_014390	NP_055205	Q7KZF4	SND1_HUMAN	staphylococcal nuclease domain containing 1	830					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CCTGCTCAACGTGGAACACCT	0.597			NA											19	81					1.56452e-12	1.99722e-12	0.007413	1	0
FLNC	2318	broad.mit.edu	37	7	128478681	128478681	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:128478681T>C	uc003vnz.3	+	8	1444	c.1235T>C	c.(1234-1236)GTG>GCG	p.V412A	FLNC_uc003voa.3_Missense_Mutation_p.V412A	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	412	Filamin 2.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GATGTTGCTGTGGTGATCGTG	0.652			NA											57	118					0	0	0.00361	0	0
FLNC	2318	broad.mit.edu	37	7	128486948	128486948	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:128486948G>C	uc003vnz.3	+	24	4486	c.4277G>C	c.(4276-4278)CGG>CCG	p.R1426P	FLNC_uc003voa.3_Missense_Mutation_p.R1426P	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1426	Filamin 12.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						TTCGGGGGGCGGCCCATCCCA	0.592			NA											41	33					0	0	0.009718	0	0
FLNC	2318	broad.mit.edu	37	7	128498253	128498253	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:128498253G>T	uc003vnz.3	+	47	8181	c.7972G>T	c.(7972-7974)GTG>TTG	p.V2658L	FLNC_uc003voa.3_Missense_Mutation_p.V2625L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	2658	Interaction with INPPL1.|Filamin 24.|Self-association site, tail (By similarity).				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CTCCTTCACCGTGGACTGCAG	0.647			NA											29	24					2.12129e-23	3.28468e-23	0.00361	1	0
SMO	6608	broad.mit.edu	37	7	128843410	128843410	+	Missense_Mutation	SNP	C	C	A	rs143083812	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:128843410C>A	uc003vor.2	+	2	797	c.517C>A	c.(517-519)CGC>AGC	p.R173S		NM_005631	NP_005622	Q99835	SMO_HUMAN	smoothened precursor	173	FZ.|Extracellular (Potential).				adenohypophysis development|axon extension involved in axon guidance|canonical Wnt receptor signaling pathway|cardioblast differentiation|central nervous system neuron differentiation|cerebellar cortex morphogenesis|ciliary receptor clustering involved in smoothened signaling pathway|determination of left/right symmetry|dorsal/ventral neural tube patterning|embryonic camera-type eye development|embryonic digestive tract morphogenesis|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|exocrine pancreas development|facial nerve development|floor plate formation|gonad development|heart morphogenesis|muscle cell fate commitment|negative regulation of apoptosis|neural crest cell migration|neuron fate commitment|neuron projection regeneration|odontogenesis of dentine-containing tooth|osteoblast differentiation|otolith morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of neuroblast proliferation|positive regulation of smoothened signaling pathway|semicircular canal morphogenesis|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|smoothened signaling pathway involved in ventral spinal cord patterning|spermatogenesis|vasculogenesis	cilium|cytoplasm|integral to membrane|neuronal cell body|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(19)|large_intestine(10)|central_nervous_system(3)|upper_aerodigestive_tract(2)|biliary_tract(1)|lung(1)|liver(1)	37						CACTCCTGACCGCTTCCCTGA	0.677			NA	Mis		skin basal cell 								9	10					1.58986e-06	1.77324e-06	0.008291	1	0
AHCYL2	23382	broad.mit.edu	37	7	129062682	129062682	+	Missense_Mutation	SNP	C	C	A	rs148610666		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:129062682C>A	uc011kov.1	+	13	1517	c.1463C>A	c.(1462-1464)GCG>GAG	p.A488E	AHCYL2_uc003vot.2_Missense_Mutation_p.A487E|AHCYL2_uc003vov.2_Missense_Mutation_p.A385E|AHCYL2_uc011kow.1_Missense_Mutation_p.A386E|AHCYL2_uc011kox.1_Missense_Mutation_p.A385E	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	488					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GTGTTCCAGGCGAGTCTGCGG	0.502	Pancreas(160;1736 1964 29875 40941 45605)		NA											20	58					4.96729e-08	5.77328e-08	0.008871	1	0
TSGA13	114960	broad.mit.edu	37	7	130357665	130357665	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:130357665G>T	uc003vqi.2	-	6	896	c.439C>A	c.(439-441)CCT>ACT	p.P147T	TSGA13_uc003vqj.2_Missense_Mutation_p.P147T	NM_052933	NP_443165	Q96PP4	TSG13_HUMAN	testis specific, 13	147										ovary(2)	2	Melanoma(18;0.0435)					TTTTTCTGAGGCATGCGGGGC	0.468			NA											32	6					1.13719e-10	1.39995e-10	0.008361	1	0
PLXNA4	91584	broad.mit.edu	37	7	131829931	131829931	+	Silent	SNP	A	A	T	rs138367497	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:131829931A>T	uc003vra.3	-	29	5401	c.5172T>A	c.(5170-5172)GCT>GCA	p.A1724A	PLXNA4_uc003vqz.3_Silent_p.A9A	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1724	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CATGTTTATCAGCCTGCTCAT	0.577			NA											44	37					0	0	0.00361	0	0
TMEM140	55281	broad.mit.edu	37	7	134849422	134849422	+	Silent	SNP	C	C	A	rs145562868	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:134849422C>A	uc003vsi.2	+	2	510	c.229C>A	c.(229-231)CGG>AGG	p.R77R	C7orf49_uc003vsh.2_Intron	NM_018295	NP_060765	Q9NV12	TM140_HUMAN	transmembrane protein 140	77	Extracellular (Potential).					integral to membrane				large_intestine(1)	1						GGGGGTGCCTCGGGTTGGCCT	0.612			NA											88	19					4.066e-59	7.53223e-59	0.00361	1	0
SLC13A4	26266	broad.mit.edu	37	7	135376069	135376069	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:135376069C>T	uc003vta.2	-	13	2012	c.1323G>A	c.(1321-1323)GAG>GAA	p.E441E	SLC13A4_uc003vtb.2_Silent_p.E442E|PL-5283_uc003vsz.3_Intron	NM_012450	NP_036582	Q9UKG4	S13A4_HUMAN	solute carrier family 13 (sodium/sulfate	441						integral to plasma membrane	sodium:sulfate symporter activity				0						GCTCCTGGTTCTCTCCTGGAT	0.512			NA											27	50					0	0	0.002096	0	0
CHRM2	1129	broad.mit.edu	37	7	136700959	136700959	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:136700959G>A	uc003vtf.1	+	4	1970	c.1347G>A	c.(1345-1347)AAG>AAA	p.K449K	CHRM2_uc003vtg.1_Silent_p.K449K|CHRM2_uc003vtj.1_Silent_p.K449K|CHRM2_uc003vtk.1_Silent_p.K449K|CHRM2_uc003vtl.1_Silent_p.K449K|CHRM2_uc003vtm.1_Silent_p.K449K|CHRM2_uc003vti.1_Silent_p.K449K|CHRM2_uc003vto.1_Silent_p.K449K|CHRM2_uc003vtn.1_Silent_p.K449K|uc003vtp.1_Intron	NM_001006630	NP_001006631	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	449	Cytoplasmic (By similarity).				activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			ovary(4)|central_nervous_system(1)	5					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium(DB01334)|Doxacurium chloride(DB01135)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	CCTTCAAGAAGACCTTTAAAC	0.433			NA											71	15					0	0	0.00361	0	0
DENND2A	27147	broad.mit.edu	37	7	140246698	140246698	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:140246698G>T	uc010lnj.2	-	11	2224	c.2079C>A	c.(2077-2079)GCC>GCA	p.A693A	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Silent_p.A693A|DENND2A_uc003vvw.2_Silent_p.A693A|DENND2A_uc003vvx.2_Silent_p.A693A	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	693	DENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GCTGAACCAGGGCAGGAGAGA	0.527			NA											31	9					4.65686e-17	6.48407e-17	0.003755	1	0
MGAM	8972	broad.mit.edu	37	7	141730439	141730439	+	Splice_Site	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:141730439A>T	uc003vwy.2	+	12	1408	c.1354_splice	c.e12-2	p.D452_splice		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase						polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TCCTATTTTTAGGATCCAGCC	0.453			NA											41	10					0	0	0.00874	0	0
MGAM	8972	broad.mit.edu	37	7	141736737	141736737	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:141736737C>T	uc003vwy.2	+	18	2245	c.2191C>T	c.(2191-2193)CAC>TAC	p.H731Y		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	731	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTTCCGTGCTCACAGCCGAGG	0.478			NA											123	24					0	0	0.00361	0	0
TRPV5	56302	broad.mit.edu	37	7	142625798	142625798	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:142625798C>A	uc003wby.1	-	6	1014	c.750G>T	c.(748-750)GAG>GAT	p.E250D	TRPV5_uc003wbz.2_Missense_Mutation_p.E250D	NM_019841	NP_062815	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel,	250	ANK 5.|Cytoplasmic (Potential).				protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			ovary(3)|central_nervous_system(2)|skin(1)	6	Melanoma(164;0.059)					CAGTGTTACCCTCCACTCCAG	0.587			NA											17	2					1.15088e-07	1.32252e-07	0.004007	1	0
C7orf34	135927	broad.mit.edu	37	7	142636792	142636792	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:142636792C>T	uc003wca.2	+	1	190	c.149C>T	c.(148-150)CCT>CTT	p.P50L		NM_178829	NP_849151	Q96L11	CG034_HUMAN	hypothetical protein LOC135927	25						extracellular region					0	Melanoma(164;0.059)					CAGGTGAAGCCTCTGAACGGG	0.597			NA											44	13					0	0	0.003214	0	0
OR9A2	135924	broad.mit.edu	37	7	142723979	142723979	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:142723979G>T	uc003wcc.1	-	1	241	c.241C>A	c.(241-243)CTT>ATT	p.L81I		NM_001001658	NP_001001658	Q8NGT5	OR9A2_HUMAN	olfactory receptor, family 9, subfamily A,	81	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.059)					AATCCCCAAAGCATCATGGGG	0.478			NA											24	40					6.21321e-17	8.63244e-17	0.00278	1	0
TAS2R41	259287	broad.mit.edu	37	7	143175593	143175593	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:143175593C>T	uc003wdc.1	+	1	628	c.628C>T	c.(628-630)CAT>TAT	p.H210Y	uc003wda.2_Intron	NM_176883	NP_795364	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	210	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			pancreas(1)|skin(1)	2	Melanoma(164;0.15)					TCTGAGGAGGCATACTCAGAG	0.463			NA											36	8					0	0	0.002836	0	0
OR6B1	135946	broad.mit.edu	37	7	143701656	143701656	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:143701656C>A	uc003wdt.1	+	1	567	c.567C>A	c.(565-567)TGC>TGA	p.C189*		NM_001005281	NP_001005281	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Melanoma(164;0.0783)					ATCTCTCCTGCACAGACATGT	0.473			NA											21	56					8.10497e-08	9.39749e-08	0.010504	1	0
NOBOX	135935	broad.mit.edu	37	7	144096865	144096865	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:144096865G>T	uc011kue.1	-	6	1139	c.1139C>A	c.(1138-1140)GCC>GAC	p.A380D		NM_001080413	NP_001073882	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	380					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			ovary(1)	1	Melanoma(164;0.14)					TTGACTGCTGGCAGGGCCAGG	0.537			NA											13	2					4.3838e-07	4.96386e-07	0.001855	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146829583	146829583	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:146829583C>A	uc003weu.1	+	8	1846	c.1330C>A	c.(1330-1332)CAA>AAA	p.Q444K		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	444	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CAAGATGAGCCAAATCGATAT	0.408			NA								HNSCC(39;0.1)			29	7					6.38683e-12	8.06275e-12	0.008361	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147092857	147092857	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:147092857G>A	uc003weu.1	+	10	2171	c.1655G>A	c.(1654-1656)TGT>TAT	p.C552Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	552	Extracellular (Potential).|Laminin G-like 2.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ATTGACATGTGTGCGATCATA	0.433			NA								HNSCC(39;0.1)			54	8					0	0	0.00361	0	0
EZH2	2146	broad.mit.edu	37	7	148544290	148544290	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:148544290C>A	uc003wfd.1	-	2	267	c.101G>T	c.(100-102)CGA>CTA	p.R34L	EZH2_uc011kug.1_Missense_Mutation_p.R34L|EZH2_uc003wfb.1_Missense_Mutation_p.R34L|EZH2_uc003wfc.1_Missense_Mutation_p.R34L|EZH2_uc011kuh.1_Missense_Mutation_p.R34L|EZH2_uc011kui.1_Missense_Mutation_p.R34L|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	34	Interaction with DNMT1, DNMT3A and DNMT3B.				negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			TTCATCAGCTCGTCTGAACCT	0.378			NA	Mis		DLBCL								77	83					3.41413e-29	5.63871e-29	0.00361	1	0
ZNF282	8427	broad.mit.edu	37	7	148895563	148895563	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:148895563G>A	uc003wfm.2	+	2	409	c.304G>A	c.(304-306)GTG>ATG	p.V102M	ZNF282_uc011kun.1_Missense_Mutation_p.V102M|ZNF282_uc003wfn.2_Missense_Mutation_p.V42M|ZNF282_uc003wfo.2_Missense_Mutation_p.V42M	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	102					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CTGGACTGTGGTGGCTGCCAT	0.617			NA											41	5					0	0	0.007835	0	0
SSPO	23145	broad.mit.edu	37	7	149480302	149480302	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:149480302G>A	uc010lpk.2	+	16	2184	c.2184G>A	c.(2182-2184)GTG>GTA	p.V728V	SSPO_uc010lpl.1_Silent_p.V63V	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	728	VWFD 2.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGTTCCAGGTGGCCGGCAAGG	0.622			NA											16	13					0	0	0.003163	0	0
GIMAP7	168537	broad.mit.edu	37	7	150217137	150217137	+	Silent	SNP	G	G	T	rs114459899	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:150217137G>T	uc003whk.2	+	2	205	c.75G>T	c.(73-75)GCG>GCT	p.A25A		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	25							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGCAACAGCGAACACCATCC	0.512			NA											43	8					6.2361e-21	9.34208e-21	0.007835	1	0
GIMAP4	55303	broad.mit.edu	37	7	150266999	150266999	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:150266999C>T	uc003whl.2	+	2	92	c.10C>T	c.(10-12)CAA>TAA	p.Q4*	GIMAP4_uc011kuu.1_5'UTR|GIMAP4_uc011kuv.1_Nonsense_Mutation_p.Q4*	NM_018326	NP_060796	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	4							GTP binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AATGGCAGCCCAATACGGCAG	0.512			NA											31	7					0	0	0.004878	0	0
NOS3	4846	broad.mit.edu	37	7	150704224	150704224	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:150704224C>A	uc003wif.2	+	17	2268	c.1972C>A	c.(1972-1974)CCC>ACC	p.P658T	NOS3_uc011kuy.1_Missense_Mutation_p.P452T	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	658	Flavodoxin-like.|FMN (By similarity).				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CCGGGCATACCCCCACTTCTG	0.687			NA											79	15					6.44082e-31	1.08036e-30	0.00361	1	0
DPP6	1804	broad.mit.edu	37	7	154143368	154143368	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:154143368G>T	uc003wlk.2	+	2	442	c.313G>T	c.(313-315)GTC>TTC	p.V105F	DPP6_uc003wli.2_Missense_Mutation_p.V41F|DPP6_uc003wlj.2_Missense_Mutation_p.V105F|DPP6_uc010lqh.1_Missense_Mutation_p.V43F|DPP6_uc003wlm.2_Missense_Mutation_p.V43F|DPP6_uc011kvq.1_Missense_Mutation_p.V43F	NM_130797	NP_570629	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6 isoform 1	105	Helical; Signal-anchor for type II membrane protein; (Potential).				cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			pancreas(3)|breast(1)	4	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TGTCATTCTGGTCATCTGCTC	0.458	NSCLC(125;1384 1783 2490 7422 34254)		NA											29	7					3.99451e-17	5.57789e-17	0.009535	1	0
CSMD1	64478	broad.mit.edu	37	8	2808674	2808674	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:2808674G>T	uc011kwk.1	-	66	10556	c.10166C>A	c.(10165-10167)ACC>AAC	p.T3389N	CSMD1_uc011kwj.1_Missense_Mutation_p.T2703N|CSMD1_uc010lrg.2_Missense_Mutation_p.T1280N	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3389	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTCGCTGAAGGTGGCATTCAC	0.453			NA											10	4					4.68919e-08	5.45661e-08	0.008291	1	0
CSMD1	64478	broad.mit.edu	37	8	2832080	2832081	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:2832080_2832081CC>AA	uc011kwk.1	-	56	9025_9026	c.8635_8636GG>TT	c.(8635-8637)GGC>TTC	p.G2879F	CSMD1_uc011kwj.1_Missense_Mutation_p.G2208F|CSMD1_uc010lrg.2_Missense_Mutation_p.G889F	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2879	Sushi 21.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CACGACGGCGCCATAGGTAAAC	0.559			NA											7	0					0	0	0.004672	0	0
AGPAT5	55326	broad.mit.edu	37	8	6614774	6614774	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:6614774G>T	uc003wqo.2	+	8	1272	c.960G>T	c.(958-960)AAG>AAT	p.K320N	AGPAT5_uc011kwm.1_3'UTR	NM_018361	NP_060831	Q9NUQ2	PLCE_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 5	320					phospholipid biosynthetic process	integral to membrane|mitochondrion	1-acylglycerol-3-phosphate O-acyltransferase activity				0			STAD - Stomach adenocarcinoma(24;0.0578)	READ - Rectum adenocarcinoma(644;0.156)|COAD - Colon adenocarcinoma(149;0.191)		GTATCAAGAAGACTTTACCAT	0.393			NA											18	5					1.45105e-14	1.9182e-14	0.006122	1	0
TNKS	8658	broad.mit.edu	37	8	9634226	9634226	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:9634226G>C	uc003wss.2	+	27	3969	c.3964G>C	c.(3964-3966)GCC>CCC	p.A1322P	TNKS_uc011kww.1_Missense_Mutation_p.A1085P	NM_003747	NP_003738	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related	1322					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			lung(4)|ovary(2)|kidney(1)	7				COAD - Colon adenocarcinoma(149;0.0467)		GACCGCAACAGCCGCAGAGCA	0.468			NA											16	7					0	0	0.00499	0	0
PINX1	54984	broad.mit.edu	37	8	10623340	10623340	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:10623340C>A	uc003wth.2	-	7	591	c.558G>T	c.(556-558)ATG>ATT	p.M186I	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_Missense_Mutation_p.G161C	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	186				RM -> PV (in Ref. 2; AAK31790).	mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)		TCAGTGCTGCCATCCGCTTGG	0.542			NA											76	36					1.38705e-31	2.33672e-31	0.00361	1	0
AMAC1L2	83650	broad.mit.edu	37	8	11189033	11189033	+	Missense_Mutation	SNP	G	G	T	rs145196437	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:11189033G>T	uc003wtp.1	+	1	539	c.418G>T	c.(418-420)GTA>TTA	p.V140L		NM_054028	NP_473369	Q96KT7	AMCL2_HUMAN	acyl-malonyl condensing enzyme	140	DUF6 1.					integral to membrane					0			STAD - Stomach adenocarcinoma(15;0.00676)	COAD - Colon adenocarcinoma(149;0.0563)		TTCTTCCACCGTATGCTCCGC	0.577			NA											57	30					2.23044e-30	3.72832e-30	0.00361	1	0
DLC1	10395	broad.mit.edu	37	8	13357256	13357256	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:13357256G>A	uc003wwm.2	-	2	769	c.325C>T	c.(325-327)CAT>TAT	p.H109Y	DLC1_uc003wwn.2_Missense_Mutation_p.H109Y|DLC1_uc011kxy.1_Missense_Mutation_p.H109Y	NM_182643	NP_872584	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1 isoform 1	109					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			ovary(3)|pancreas(2)|lung(1)|kidney(1)	7						TCAGAAACATGCACTAGTGTT	0.418			NA											86	42					0	0	0.00361	0	0
SGCZ	137868	broad.mit.edu	37	8	13948043	13948043	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:13948043A>G	uc003wwq.2	-	8	1508	c.848T>C	c.(847-849)CTC>CCC	p.L283P	SGCZ_uc010lss.2_Missense_Mutation_p.L236P	NM_139167	NP_631906	Q96LD1	SGCZ_HUMAN	sarcoglycan zeta	270	Extracellular (Potential).				cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				ovary(2)|central_nervous_system(1)	3				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		GCAGACGCAGAGTTCATACAC	0.478			NA											35	14					0	0	0.003271	0	0
PCM1	5108	broad.mit.edu	37	8	17815210	17815210	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:17815210G>C	uc003wyi.3	+	13	2388	c.1966G>C	c.(1966-1968)GAA>CAA	p.E656Q	PCM1_uc011kyh.1_Missense_Mutation_p.E656Q|PCM1_uc003wyj.3_Missense_Mutation_p.E657Q|PCM1_uc010lta.1_Missense_Mutation_p.E695Q	NM_006197	NP_006188	Q15154	PCM1_HUMAN	pericentriolar material 1	656	Potential.				centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	haematopoietic_and_lymphoid_tissue(30)|breast(4)|ovary(2)	36				Colorectal(111;0.0789)		TGCTGAATTTGAACAGAAGAT	0.338			NA	T	RET|JAK2	papillary thyroid|CML|MPD								10	1					0	0	0.006214	0	0
HR	55806	broad.mit.edu	37	8	21986575	21986575	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:21986575G>T	uc003xas.2	-	2	774	c.109C>A	c.(109-111)CAC>AAC	p.H37N	HR_uc003xat.2_Missense_Mutation_p.H37N|HR_uc010lts.2_Missense_Mutation_p.H37N	NM_005144	NP_005135	O43593	HAIR_HUMAN	hairless protein isoform a	37							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGCCCATGGTGCAGTCCATCT	0.677			NA											26	12					4.22769e-11	5.27167e-11	0.00632	1	0
ADAM28	10863	broad.mit.edu	37	8	24199146	24199146	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:24199146G>T	uc003xdy.2	+	16	1789	c.1706G>T	c.(1705-1707)GGG>GTG	p.G569V	ADAM28_uc011laa.1_RNA|ADAM28_uc010lua.2_Missense_Mutation_p.G256V	NM_014265	NP_055080	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28 isoform 1	569	Extracellular (Potential).|Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(3)|lung(1)|central_nervous_system(1)	5		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		TGTCAAGGTGGGTCGGATAAT	0.413	NSCLC(193;488 2149 22258 34798 40734)		NA											46	24					1.05386e-31	1.77695e-31	0.00361	1	0
ADAMDEC1	27299	broad.mit.edu	37	8	24251623	24251623	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:24251623C>T	uc003xdz.2	+	4	546	c.326C>T	c.(325-327)CCC>CTC	p.P109L	ADAMDEC1_uc010lub.2_Missense_Mutation_p.P30L|ADAMDEC1_uc011lab.1_Missense_Mutation_p.P30L	NM_014479	NP_055294	O15204	ADEC1_HUMAN	ADAM-like, decysin 1 isoform 1	109					integrin-mediated signaling pathway|negative regulation of cell adhesion|proteolysis	extracellular region|integral to membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			skin(2)	2		Prostate(55;0.0181)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)|BRCA - Breast invasive adenocarcinoma(99;0.168)		TTGTACTCACCCAGAGGAGAG	0.463	Ovarian(147;687 1849 3699 25981 31337)		NA											7	4					0	0	0.004482	0	0
TRIM35	23087	broad.mit.edu	37	8	27145298	27145298	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:27145298C>A	uc003xfl.1	-	6	1333	c.1251G>T	c.(1249-1251)ACG>ACT	p.T417T	TRIM35_uc010lup.1_3'UTR	NM_171982	NP_741983	Q9UPQ4	TRI35_HUMAN	tripartite motif-containing 35 isoform 2	417	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding				0		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		CCAGGGGCGACGTGGCTGGGT	0.667			NA											7	5					0.00198382	0.00205832	0.001984	1	0
SCARA5	286133	broad.mit.edu	37	8	27737272	27737272	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:27737272C>A	uc003xgj.2	-	8	1605	c.1165G>T	c.(1165-1167)GCC>TCC	p.A389S	SCARA5_uc010luz.2_Missense_Mutation_p.A164S	NM_173833	NP_776194	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5	389	Extracellular (Potential).				cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|skin(1)	2		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		ATCATCGGGGCCTCCACGCCA	0.662			NA											13	6					4.3838e-07	4.96386e-07	0.001855	1	0
WRN	7486	broad.mit.edu	37	8	31030607	31030607	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:31030607C>G	uc003xio.3	+	35	5076	c.4288C>G	c.(4288-4290)CTT>GTT	p.L1430V	WRN_uc010lvk.2_Missense_Mutation_p.L897V	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1430					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		AAGGGGAGGTCTTTTTAGTTA	0.363	Ovarian(18;161 598 2706 14834 27543)		NA	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				10	3					0	0	0.001368	0	0
KCNU1	157855	broad.mit.edu	37	8	36664969	36664969	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:36664969G>T	uc010lvw.2	+	6	743	c.656_splice	c.e6+1	p.S219_splice	KCNU1_uc003xjw.2_Splice_Site	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1							voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCAAGACCAGGTAAATAGCCC	0.393			NA											72	60					2.72615e-36	4.71169e-36	0.00361	1	0
ERLIN2	11160	broad.mit.edu	37	8	37609233	37609233	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:37609233G>A	uc003xke.3	+	10	854	c.739G>A	c.(739-741)GAT>AAT	p.D247N		NM_007175	NP_009106	O94905	ERLN2_HUMAN	ER lipid raft associated 2 isoform 1	247	Interaction with ERLIN1.|Lumenal (Potential).				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding				0		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			AGAAATTGAAGGTAAGCAGAA	0.527			NA											18	23					0	0	0.006122	0	0
TACC1	6867	broad.mit.edu	37	8	38699955	38699955	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:38699955G>T	uc010lwp.2	+	10	2490	c.2111G>T	c.(2110-2112)GGG>GTG	p.G704V	TACC1_uc003xma.2_Missense_Mutation_p.G142V|TACC1_uc003xlz.2_Missense_Mutation_p.G509V|TACC1_uc003xmc.3_Missense_Mutation_p.G508V|TACC1_uc011lbz.1_Missense_Mutation_p.G691V|TACC1_uc003xmb.3_Missense_Mutation_p.G630V|TACC1_uc003xmf.3_Missense_Mutation_p.G294V|TACC1_uc011lca.1_Missense_Mutation_p.G687V|TACC1_uc011lcb.1_Missense_Mutation_p.G480V|TACC1_uc011lcd.1_RNA|TACC1_uc003xmh.3_Missense_Mutation_p.G521V|TACC1_uc010lwq.2_Missense_Mutation_p.G520V	NM_006283	NP_006274	O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing	704	|Interaction with CH-TOG.				cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			ovary(1)	1		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			GTTCTGGAAGGGTTCAAGAAG	0.453			NA											44	42					5.48756e-27	8.88113e-27	0.002852	1	0
TM2D2	83877	broad.mit.edu	37	8	38848959	38848959	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:38848959C>A	uc003xmk.2	-	4	620	c.537G>T	c.(535-537)AAG>AAT	p.K179N	TM2D2_uc003xml.2_Missense_Mutation_p.K136N|TM2D2_uc003xmm.2_Missense_Mutation_p.K136N|TM2D2_uc003xmn.2_Missense_Mutation_p.K136N	NM_078473	NP_510882	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2 isoform a	179						integral to membrane					0		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GCGTCAACAGCTTCCCTACTG	0.488			NA											14	36					4.14922e-12	5.25513e-12	0.004007	1	0
ADAM18	8749	broad.mit.edu	37	8	39486892	39486892	+	Splice_Site	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:39486892G>T	uc003xni.2	+	7	523	c.523_splice	c.e7-1	p.I175_splice	ADAM18_uc010lww.2_Splice_Site|ADAM18_uc010lwx.2_Splice_Site_p.I175_splice	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	a disintegrin and metalloprotease domain 18						cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)|kidney(1)|skin(1)	6		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			TTGTTTTCCAGATAAAAAATC	0.289			NA											19	23					1.01871e-10	1.2557e-10	0.008871	1	0
IDO1	3620	broad.mit.edu	37	8	39776358	39776358	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:39776358C>A	uc003xnm.2	+	4	442	c.328C>A	c.(328-330)CCT>ACT	p.P110T	IDO1_uc003xnn.2_RNA	NM_002164	NP_002155	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	110					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)	2					L-Tryptophan(DB00150)	TATTGCTGTTCCTTACTGCCA	0.318			NA											25	62					6.36457e-07	7.16478e-07	0.003954	1	0
SFRP1	6422	broad.mit.edu	37	8	41166586	41166586	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:41166586G>A	uc003xnt.2	-	1	395	c.93C>T	c.(91-93)GCC>GCT	p.A31A		NM_003012	NP_003003	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1 precursor	31					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CGTACTCGCTGGCCGAGCCCA	0.731			NA											18	9					0	0	0.006122	0	0
AGPAT6	137964	broad.mit.edu	37	8	41469465	41469465	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:41469465C>G	uc003xnz.2	+	6	1594	c.655C>G	c.(655-657)CGG>GGG	p.R219G		NM_178819	NP_848934	Q86UL3	GPAT4_HUMAN	lysophosphatidic acid acyltransferase zeta	219					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity				0	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			AATGTGTTACCGGATCTGCGT	0.458			NA											11	50					0	0	0.000978	0	0
SLC20A2	6575	broad.mit.edu	37	8	42323300	42323300	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:42323300T>C	uc010lxl.2	-	3	1119	c.425A>G	c.(424-426)AAG>AGG	p.K142R	SLC20A2_uc010lxm.2_Missense_Mutation_p.K142R|SLC20A2_uc003xpe.2_Missense_Mutation_p.K142R	NM_006749	NP_006740	Q08357	S20A2_HUMAN	solute carrier family 20, member 2	142	Extracellular (Potential).				interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			ovary(2)	2	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			ATTACCAATCTTGACAAGCTC	0.358			NA											46	25					0	0	0.00361	0	0
SGK196	84197	broad.mit.edu	37	8	42977541	42977541	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:42977541C>G	uc003xpw.2	+	5	833	c.574C>G	c.(574-576)CTG>GTG	p.L192V		NM_032237	NP_115613	Q9H5K3	SG196_HUMAN	protein kinase-like protein SgK196	192	Protein kinase.					integral to membrane	ATP binding|protein kinase activity				0						CATTAATTACCTGCACCACAG	0.502			NA											16	48					0	0	0.00499	0	0
POTEA	340441	broad.mit.edu	37	8	43197396	43197396	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:43197396G>A	uc003xpz.1	+	11	1328	c.1285G>A	c.(1285-1287)GAG>AAG	p.E429K	POTEA_uc003xqa.1_Missense_Mutation_p.E383K	NM_001005365	NP_001005365	Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A isoform 2	429										ovary(1)	1						AATAGCGTCAGAGGATTATGA	0.358			NA											22	58					0	0	0.010504	0	0
MCM4	4173	broad.mit.edu	37	8	48889288	48889288	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:48889288G>T	uc003xqk.1	+	17	2637	c.2542G>T	c.(2542-2544)GCA>TCA	p.A848S	MCM4_uc003xql.1_Missense_Mutation_p.A848S|MCM4_uc011ldi.1_Missense_Mutation_p.A835S	NM_182746	NP_877423	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	848					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			ovary(2)|skin(2)	4		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				GCGTGCCCTGGCAGATGATGA	0.488			NA											19	115					1.9806e-07	2.27328e-07	0.002299	1	0
SNAI2	6591	broad.mit.edu	37	8	49832655	49832656	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:49832655_49832656CC>AA	uc003xqp.2	-	2	588_589	c.424_425GG>TT	c.(424-426)GGG>TTG	p.G142L		NM_003068	NP_003059	O43623	SNAI2_HUMAN	snail 2	142	C2H2-type 1.				canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				TTTGGCCAGCCCAGAAAAAGTT	0.45			NA											32	71					0	0	0.004672	0	0
OPRK1	4986	broad.mit.edu	37	8	54147573	54147573	+	Missense_Mutation	SNP	T	T	A	rs148980561	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:54147573T>A	uc003xrh.1	-	2	731	c.356A>T	c.(355-357)TAC>TTC	p.Y119F	OPRK1_uc003xri.1_Missense_Mutation_p.Y119F|OPRK1_uc010lyc.1_Missense_Mutation_p.Y30F	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	119	Extracellular (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	ATTCATCAAGTAGACCGTACT	0.408			NA											45	36					0	0	0.003214	0	0
RP1	6101	broad.mit.edu	37	8	55539845	55539845	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:55539845G>T	uc003xsd.1	+	4	3551	c.3403G>T	c.(3403-3405)GTG>TTG	p.V1135L	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1135					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTGGCTCTTGGTGCTAAACCT	0.403	Colon(91;1014 1389 7634 14542 40420)		NA											17	35					1.15088e-07	1.32252e-07	0.004007	1	0
RP1	6101	broad.mit.edu	37	8	55541689	55541689	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:55541689A>T	uc003xsd.1	+	4	5395	c.5247A>T	c.(5245-5247)AAA>AAT	p.K1749N	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	1749					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGCTTCTGAAAGAAAATCATT	0.418	Colon(91;1014 1389 7634 14542 40420)		NA											15	32					0	0	0.004007	0	0
TMEM68	137695	broad.mit.edu	37	8	56675305	56675305	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:56675305G>C	uc003xsg.1	-	1	283	c.214C>G	c.(214-216)CAC>GAC	p.H72D	TMEM68_uc003xsh.1_Missense_Mutation_p.H72D|TMEM68_uc003xsi.1_Missense_Mutation_p.H72D	NM_152417	NP_689630	Q96MH6	TMM68_HUMAN	transmembrane protein 68	72						integral to membrane	acyltransferase activity			skin(1)	1			Epithelial(17;0.000361)|all cancers(17;0.00326)			TTATAAATGTGTAAGAAAATA	0.343			NA											38	31					0	0	0.004289	0	0
CYP7B1	9420	broad.mit.edu	37	8	65517310	65517310	+	Nonsense_Mutation	SNP	G	G	A	rs72554620		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:65517310G>A	uc003xvj.2	-	5	1366	c.1162C>T	c.(1162-1164)CGA>TGA	p.R388*		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	388					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				TCTCCCTTTCGCACACAGTAG	0.453			NA											53	40					0	0	0.00361	0	0
PREX2	80243	broad.mit.edu	37	8	69021769	69021769	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:69021769C>G	uc003xxv.1	+	25	3084	c.3057C>G	c.(3055-3057)GAC>GAG	p.D1019E	PREX2_uc011lez.1_Missense_Mutation_p.D954E	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1019					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						AAGAAGAAGACTTAGAAACCC	0.463			NA											24	89					0	0	0.00333	0	0
SULF1	23213	broad.mit.edu	37	8	70536307	70536307	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:70536307G>T	uc010lza.1	+	15	2442	c.1725G>T	c.(1723-1725)AAG>AAT	p.K575N	SULF1_uc003xyd.2_Missense_Mutation_p.K575N|SULF1_uc003xye.2_Missense_Mutation_p.K575N|SULF1_uc003xyf.2_Missense_Mutation_p.K575N|SULF1_uc003xyg.2_Missense_Mutation_p.K575N|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	575					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ACATTGCTAAGCGTCATGATG	0.498			NA											9	34					2.17888e-05	2.37539e-05	0.006214	1	0
SULF1	23213	broad.mit.edu	37	8	70551059	70551059	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:70551059G>A	uc010lza.1	+	21	3234	c.2517G>A	c.(2515-2517)AAG>AAA	p.K839K	SULF1_uc003xyd.2_Silent_p.K839K|SULF1_uc003xye.2_Silent_p.K839K|SULF1_uc003xyf.2_Silent_p.K839K|SULF1_uc003xyg.2_Silent_p.K839K|SULF1_uc003xyh.1_RNA|SULF1_uc003xyi.1_5'UTR|SULF1_uc003xyj.1_5'UTR	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	839					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			AAGGATATAAGCAGTGCAACC	0.388			NA											14	51					0	0	0.003163	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768195	77768195	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:77768195G>T	uc003yav.2	+	10	9290	c.8903G>T	c.(8902-8904)GGG>GTG	p.G2968V	ZFHX4_uc003yau.1_Missense_Mutation_p.G3013V|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2968V	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2968	C2H2-type 18.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACCCTCTGCGGGGTGAAGTAC	0.483			NA								HNSCC(33;0.089)			17	15					1.45105e-14	1.9182e-14	0.006122	1	0
LRRCC1	85444	broad.mit.edu	37	8	86027440	86027441	+	Missense_Mutation	DNP	TG	TG	CT			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:86027440_86027441TG>CT	uc003ycw.2	+	5	804_805	c.650_651TG>CT	c.(649-651)CTG>CCT	p.L217P	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Intron|LRRCC1_uc003ycx.2_Missense_Mutation_p.L124P|LRRCC1_uc003ycy.2_Missense_Mutation_p.L197P	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	217	LRRCT.				cell division|mitosis	centriole|nucleus					0						TCATCACAGCTGCAGTGCCTAG	0.337			NA											13	28					0	0	0.004672	0	0
PSKH2	85481	broad.mit.edu	37	8	87076713	87076713	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:87076713G>T	uc011lfy.1	-	2	333	c.333C>A	c.(331-333)GTC>GTA	p.V111V		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	111	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			CCCGCCGCAGGACGCTCAGCT	0.512			NA											25	25					1.75199e-13	2.26948e-13	0.007291	1	0
CNGB3	54714	broad.mit.edu	37	8	87680390	87680390	+	Missense_Mutation	SNP	G	G	T	rs142772954		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:87680390G>T	uc003ydx.2	-	5	546	c.500C>A	c.(499-501)CCC>CAC	p.P167H	CNGB3_uc010maj.2_Missense_Mutation_p.P29H	NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	167	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						TACAGCCGTGGGCTTTGCTTC	0.318			NA											17	30					1.99824e-07	2.29081e-07	0.00499	1	0
CNGB3	54714	broad.mit.edu	37	8	87738759	87738759	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:87738759C>A	uc003ydx.2	-	3	384	c.338G>T	c.(337-339)AGC>ATC	p.S113I		NM_019098	NP_061971	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	113	Cytoplasmic (Potential).				signal transduction|visual perception	integral to membrane	cGMP binding			ovary(2)|pancreas(1)	3						AAATGCTCACCTGTTTGGACC	0.458			NA											71	103					4.83677e-39	8.50393e-39	0.00361	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88886059	88886059	+	Silent	SNP	G	G	T	rs142584363	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:88886059G>T	uc003ydz.2	-	1	238	c.141C>A	c.(139-141)CGC>CGA	p.R47R		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	47										ovary(1)	1						CACGCAGCTCGCGAGCTATAC	0.498			NA											11	37					6.40141e-05	6.88944e-05	0.000978	1	0
DPY19L4	286148	broad.mit.edu	37	8	95746894	95746894	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:95746894G>T	uc003ygx.2	+	3	288	c.164G>T	c.(163-165)GGC>GTC	p.G55V	DPY19L4_uc003ygy.2_5'UTR	NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	55	Helical; (Potential).					integral to membrane		p.G55D(1)		ovary(2)	2	Breast(36;3.85e-06)					ATTTTCATTGGCTGTCTTGCA	0.294			NA											9	16					2.17888e-05	2.37539e-05	0.006214	1	0
MATN2	4147	broad.mit.edu	37	8	98900453	98900453	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:98900453C>A	uc003yic.2	+	2	356	c.125C>A	c.(124-126)CCG>CAG	p.P42Q	MATN2_uc003yib.1_Missense_Mutation_p.P42Q|MATN2_uc010mbh.1_Missense_Mutation_p.P42Q|MATN2_uc003yid.2_Missense_Mutation_p.P42Q|MATN2_uc003yie.1_Missense_Mutation_p.P42Q	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	42						proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			CGGACCCACCCGCAGACGGCC	0.642			NA											4	6					0.00024832	0.000262719	0.009096	1	0
MATN2	4147	broad.mit.edu	37	8	98943632	98943632	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:98943632G>T	uc003yic.2	+	3	825	c.594G>T	c.(592-594)CAG>CAT	p.Q198H	MATN2_uc003yib.1_Missense_Mutation_p.Q198H|MATN2_uc010mbh.1_Missense_Mutation_p.Q198H|MATN2_uc003yid.2_Missense_Mutation_p.Q198H|MATN2_uc003yie.1_Missense_Mutation_p.Q198H|MATN2_uc010mbi.1_Missense_Mutation_p.Q72H	NM_002380	NP_002371	O00339	MATN2_HUMAN	matrilin 2 isoform a precursor	198	VWFA 1.					proteinaceous extracellular matrix	calcium ion binding			ovary(2)	2	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GTGTGGGCCAGGTAGACTTCA	0.552			NA											15	27					3.27435e-08	3.81942e-08	0.00245	1	0
NCALD	83988	broad.mit.edu	37	8	102701577	102701577	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:102701577C>G	uc003yke.2	-	4	911	c.542G>C	c.(541-543)CGC>CCC	p.R181P	NCALD_uc003ykf.2_Missense_Mutation_p.R181P|NCALD_uc003ykg.2_Missense_Mutation_p.R181P|NCALD_uc003ykh.2_Missense_Mutation_p.R181P|NCALD_uc003yki.2_Missense_Mutation_p.R181P|NCALD_uc003ykj.2_Missense_Mutation_p.R181P|NCALD_uc003ykk.2_Missense_Mutation_p.R181P|NCALD_uc003ykl.2_Missense_Mutation_p.R181P	NM_032041	NP_114430	P61601	NCALD_HUMAN	neurocalcin delta	181					synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding				0	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			CTGCAGGAGGCGCACAATGGA	0.562			NA											8	33					0	0	0.00308	0	0
ATP6V1C1	528	broad.mit.edu	37	8	104063301	104063301	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:104063301A>G	uc003ykz.3	+	5	555	c.310A>G	c.(310-312)AGG>GGG	p.R104G	ATP6V1C1_uc010mbz.2_Missense_Mutation_p.R29G|ATP6V1C1_uc003yla.2_Missense_Mutation_p.R104G|ATP6V1C1_uc011lhl.1_Missense_Mutation_p.R29G	NM_001695	NP_001686	P21283	VATC1_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit	104					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|plasma membrane|proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism				0	Lung NSC(17;0.000427)|all_lung(17;0.000533)		OV - Ovarian serous cystadenocarcinoma(57;3.57e-05)|STAD - Stomach adenocarcinoma(118;0.133)			TTATATAACAAGGTTCCAGTG	0.318			NA											28	22					0	0	0.009535	0	0
SLC25A32	81034	broad.mit.edu	37	8	104415469	104415469	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:104415469G>C	uc003yll.2	-	4	778	c.475C>G	c.(475-477)CCA>GCA	p.P159A	SLC25A32_uc011lhr.1_Missense_Mutation_p.P27A	NM_030780	NP_110407	Q9H2D1	MFTC_HUMAN	solute carrier family 25, member 32	159	Solcar 2.				folic acid metabolic process|mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding|folic acid transporter activity			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(57;2.79e-06)|STAD - Stomach adenocarcinoma(118;0.197)		Folic Acid(DB00158)	TGTCGGTGTGGGGAGTTAACA	0.338			NA											19	93					0	0	0.006122	0	0
RIMS2	9699	broad.mit.edu	37	8	105263929	105263929	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:105263929G>T	uc003yls.2	+	28	4226	c.3985G>T	c.(3985-3987)GGA>TGA	p.G1329*	RIMS2_uc003ylp.2_Nonsense_Mutation_p.G1311*|RIMS2_uc003ylq.2_Nonsense_Mutation_p.G1125*|RIMS2_uc003ylr.2_Nonsense_Mutation_p.G1150*	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1373					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TATGGTGATCGGATGGTTCAA	0.468			NA								HNSCC(12;0.0054)			250	137					5.49557e-122	1.03996e-121	0.00361	1	0
TM7SF4	81501	broad.mit.edu	37	8	105361749	105361749	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:105361749A>G	uc003ylx.1	+	2	1018	c.969A>G	c.(967-969)TCA>TCG	p.S323S		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	323					osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TCATTTTCTCAGTGAGCAAGC	0.448			NA											70	383					0	0	0.00361	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110397854	110397854	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:110397854T>A	uc003yne.2	+	6	668	c.564T>A	c.(562-564)ATT>ATA	p.I188I		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	188	Extracellular (Potential).|IPT/TIG 2.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATGTTAGGATTTTGAGGTAAT	0.294			NA								HNSCC(38;0.096)			9	15					0	0	0.008291	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110464484	110464484	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:110464484T>A	uc003yne.2	+	42	6586	c.6482T>A	c.(6481-6483)ATC>AAC	p.I2161N		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	2161	IPT/TIG 14.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTGTCCACATCAGAGGTGTC	0.458			NA								HNSCC(38;0.096)			14	29					0	0	0.004007	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509245	110509245	+	Silent	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:110509245T>G	uc003yne.2	+	64	10529	c.10425T>G	c.(10423-10425)CTT>CTG	p.L3475L		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor	3475	PbH1 8.|Extracellular (Potential).				immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GATGTTCTCTTATACAAGGAT	0.358			NA								HNSCC(38;0.096)			36	27					0	0	0.003755	0	0
SLC30A8	169026	broad.mit.edu	37	8	118175669	118175669	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:118175669G>T	uc003yoh.2	+	6	959	c.729G>T	c.(727-729)GAG>GAT	p.E243D	SLC30A8_uc010mcz.2_Missense_Mutation_p.E194D|SLC30A8_uc011lia.1_Missense_Mutation_p.E194D|SLC30A8_uc003yog.2_Missense_Mutation_p.E194D	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	243	Extracellular (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			TCTAGCCAGAGTATAAAATAG	0.388	Ovarian(162;1202 1922 6011 16223 52092)		NA											22	82					3.7963e-18	5.41449e-18	0.00333	1	0
TAF2	6873	broad.mit.edu	37	8	120810006	120810006	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:120810006A>G	uc003you.2	-	7	1143	c.873T>C	c.(871-873)TAT>TAC	p.Y291Y		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	291					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			GAATTTCTTCATAAAATTCAA	0.373			NA											5	15					0	0	0.001984	0	0
COL14A1	7373	broad.mit.edu	37	8	121267580	121267580	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:121267580A>G	uc003yox.2	+	23	3119	c.2854A>G	c.(2854-2856)ATA>GTA	p.I952V	COL14A1_uc003yoy.2_Missense_Mutation_p.I630V	NM_021110	NP_066933	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1 precursor	952	Fibronectin type-III 8.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			ovary(4)|kidney(4)|skin(2)|pancreas(1)|central_nervous_system(1)	12	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TAGGGTTGTTATAGAATCCCT	0.453			NA											33	53					0	0	0.009535	0	0
KLHL38	340359	broad.mit.edu	37	8	124657999	124657999	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:124657999G>C	uc003yqs.1	-	3	1750	c.1726C>G	c.(1726-1728)CGC>GGC	p.R576G		NM_001081675	NP_001075144	Q2WGJ6	KLH38_HUMAN	kelch-like 38	576											0						CCAGACGTGCGGGGTATGCAC	0.582			NA											32	38					0	0	0.003755	0	0
FER1L6	654463	broad.mit.edu	37	8	125074115	125074115	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:125074115T>A	uc003yqw.2	+	25	3376	c.3170T>A	c.(3169-3171)CTG>CAG	p.L1057Q	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1057	Cytoplasmic (Potential).|C2 4.					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			AACGAGCTTCTGCACCCGCCA	0.557			NA											18	37					0	0	0.00499	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428463	128428463	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:128428463C>A	uc003ysf.2	+	1	607	c.352C>A	c.(352-354)CCC>ACC	p.P118T	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_RNA	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	118						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						CTGCACCGTCCCCCCTGGTGC	0.597			NA											11	16					0.000673444	0.000705548	0.008291	1	0
ASAP1	50807	broad.mit.edu	37	8	131070229	131070229	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:131070229C>A	uc003yta.1	-	28	3314	c.3286G>T	c.(3286-3288)GTC>TTC	p.V1096F	ASAP1_uc003ysz.1_Missense_Mutation_p.V907F|ASAP1_uc011liw.1_Missense_Mutation_p.V1089F	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor	1096	SH3.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TCCCCTGTGACGATAATCACT	0.498			NA											53	54					8.99859e-20	1.31743e-19	0.00361	1	0
ADCY8	114	broad.mit.edu	37	8	132052171	132052171	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:132052171T>A	uc003ytd.3	-	1	665	c.409A>T	c.(409-411)AGC>TGC	p.S137C	ADCY8_uc010mds.2_Missense_Mutation_p.S137C	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	137	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TCCGAGTTGCTAGGGGCACAG	0.607			NA								HNSCC(32;0.087)			6	2					0	0	0.001168	0	0
TG	7038	broad.mit.edu	37	8	133975270	133975270	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:133975270G>T	uc003ytw.2	+	29	5540	c.5499G>T	c.(5497-5499)ATG>ATT	p.M1833I	TG_uc010mdw.2_Missense_Mutation_p.M592I|TG_uc011ljb.1_Missense_Mutation_p.M202I|TG_uc011ljc.1_5'Flank|TG_uc010mdx.1_RNA	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	1833	Type IIIB.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CTGAGTCTATGGGATGTAGAA	0.478			NA											60	114					9.40535e-28	1.53631e-27	0.00361	1	0
TG	7038	broad.mit.edu	37	8	134108570	134108570	+	Missense_Mutation	SNP	G	G	T	rs35664324		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:134108570G>T	uc003ytw.2	+	43	7566	c.7525G>T	c.(7525-7527)GGG>TGG	p.G2509W	TG_uc010mdw.2_Missense_Mutation_p.G1268W|TG_uc011ljb.1_Missense_Mutation_p.G878W|TG_uc011ljc.1_Missense_Mutation_p.G642W|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2509					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TCTGCTCATTGGGAGTTCTCA	0.567			NA											65	87					2.34191e-24	3.67932e-24	0.00361	1	0
ST3GAL1	6482	broad.mit.edu	37	8	134472091	134472091	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:134472091C>T	uc003yuk.2	-	10	1768	c.939G>A	c.(937-939)ACG>ACA	p.T313T	ST3GAL1_uc003yum.2_Silent_p.T313T	NM_173344	NP_775479	Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase	313	Lumenal (Potential).				protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity				0	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			CGTGCACCCCCGTCTTGCGAA	0.572			NA											49	76					0	0	0.00361	0	0
ZFAT	57623	broad.mit.edu	37	8	135614607	135614607	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:135614607C>A	uc003yup.2	-	6	1530	c.1355G>T	c.(1354-1356)AGG>ATG	p.R452M	ZFAT_uc003yun.2_Missense_Mutation_p.R440M|ZFAT_uc003yuo.2_Missense_Mutation_p.R440M|ZFAT_uc010meh.2_Missense_Mutation_p.R440M|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.R440M|ZFAT_uc010mej.2_Missense_Mutation_p.R390M|ZFAT_uc003yur.2_Missense_Mutation_p.R440M	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	452	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGGGTGCTTCCTGACATGCAG	0.612			NA											17	27					3.52763e-06	3.90747e-06	0.00499	1	0
FAM135B	51059	broad.mit.edu	37	8	139165094	139165094	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:139165094C>A	uc003yuy.2	-	13	1795	c.1624G>T	c.(1624-1626)GGT>TGT	p.G542C	FAM135B_uc003yux.2_Missense_Mutation_p.G443C|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G104C|FAM135B_uc003yvb.2_Missense_Mutation_p.G104C	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	542										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCCTCTGGACCTGGACTCCTT	0.502			NA								HNSCC(54;0.14)			30	33					3.1745e-13	4.09571e-13	0.008361	1	0
TRAPPC9	83696	broad.mit.edu	37	8	141381254	141381254	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:141381254C>T	uc003yvj.2	-	8	1294	c.1160G>A	c.(1159-1161)CGC>CAC	p.R387H	TRAPPC9_uc003yvh.2_Missense_Mutation_p.R485H|TRAPPC9_uc003yvi.1_Missense_Mutation_p.R378H	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	387					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						GATGCTGTAGCGCTGAATTTT	0.468			NA											9	14					0	0	0.008291	0	0
EIF2C2	27161	broad.mit.edu	37	8	141554341	141554341	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:141554341C>T	uc003yvn.2	-	14	1850	c.1810G>A	c.(1810-1812)GGG>AGG	p.G604R	EIF2C2_uc010men.2_Missense_Mutation_p.G527R|EIF2C2_uc010meo.2_Missense_Mutation_p.G604R	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	argonaute 2 isoform 1	604	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|mRNA cap binding complex|nucleus|polysome|RNA-induced silencing complex	endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|RNA 7-methylguanosine cap binding|siRNA binding|translation initiation factor activity				0	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			TTCCCATCCCCGGCGGGGGGG	0.642			NA											8	132					0	0	0.006214	0	0
BAI1	575	broad.mit.edu	37	8	143558878	143558878	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:143558878A>T	uc003ywm.2	+	5	1538	c.1355A>T	c.(1354-1356)CAA>CTA	p.Q452L		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	452	Extracellular (Potential).|TSP type-1 3.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCTGAGAAGCAAACCAAGTTC	0.652			NA											25	31					0	0	0.003954	0	0
TOP1MT	116447	broad.mit.edu	37	8	144403382	144403382	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:144403382C>T	uc003yxz.2	-	8	1154	c.1135G>A	c.(1135-1137)GTG>ATG	p.V379M	TOP1MT_uc011lkd.1_Missense_Mutation_p.V281M|TOP1MT_uc011lke.1_Missense_Mutation_p.V281M|TOP1MT_uc010mfb.2_Missense_Mutation_p.V281M|TOP1MT_uc011lkf.1_Missense_Mutation_p.V174M|TOP1MT_uc010mfd.1_Missense_Mutation_p.V174M	NM_052963	NP_443195	Q969P6	TOP1M_HUMAN	mitochondrial topoisomerase I precursor	379					DNA topological change	chromosome|mitochondrial nucleoid	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity			ovary(1)	1	all_cancers(97;1.01e-10)|all_epithelial(106;4.86e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.156)|Colorectal(110;0.173)		Irinotecan(DB00762)|Topotecan(DB01030)	GGCTTCTCCACCGGCACTCTG	0.637			NA											7	3					0	0	0.001984	0	0
ZC3H3	23144	broad.mit.edu	37	8	144620697	144620698	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:144620697_144620698CC>AA	uc003yyd.2	-	2	868_869	c.839_840GG>TT	c.(838-840)GGG>GTT	p.G280V		NM_015117	NP_055932	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	280					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			skin(1)	1	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TGGCGGGGCCCCCCACTGAGCC	0.614			NA											46	64					0	0	0.004672	0	0
WASH5P	375690	broad.mit.edu	37	9	17044	17044	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:17044G>C	uc010mgm.1	-	7	947	c.804C>G	c.(802-804)CCC>CCG	p.P268P	WASH5P_uc003zfr.2_RNA|WASH5P_uc011llq.1_RNA|WASH5P_uc003zfu.1_Silent_p.P281P	NM_182905	NP_878908			WAS protein family homolog 1												0						GGGCAATGCCGGGGCCCAGGT	0.627			NA											4	29					0	0	0.009096	0	0
DOCK8	81704	broad.mit.edu	37	9	404959	404959	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:404959G>A	uc003zgf.2	+	27	3388	c.3276G>A	c.(3274-3276)ATG>ATA	p.M1092I	DOCK8_uc010mgu.2_Missense_Mutation_p.M394I|DOCK8_uc010mgv.2_Missense_Mutation_p.M992I|DOCK8_uc010mgw.1_Missense_Mutation_p.M394I|DOCK8_uc003zgk.2_Missense_Mutation_p.M550I	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1092					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TCATTTCCATGAGGCTAGAGT	0.418			NA											35	8					0	0	0.007835	0	0
SMARCA2	6595	broad.mit.edu	37	9	2088558	2088558	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:2088558G>T	uc003zhc.2	+	19	2927	c.2828G>T	c.(2827-2829)AGA>ATA	p.R943I	SMARCA2_uc003zhd.2_Missense_Mutation_p.R943I|SMARCA2_uc010mha.2_Missense_Mutation_p.R876I	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	943					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		AAGGTGTTAAGACCATTTTTA	0.348			NA											90	29					9.63447e-60	1.78649e-59	0.00361	1	0
KDM4C	23081	broad.mit.edu	37	9	7011843	7011843	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:7011843C>T	uc003zkh.2	+	13	2512	c.1932C>T	c.(1930-1932)CAC>CAT	p.H644H	KDM4C_uc010mhu.2_Silent_p.H666H|KDM4C_uc011lmi.1_Silent_p.H644H|KDM4C_uc011lmj.1_RNA|KDM4C_uc003zkg.2_Silent_p.H644H|KDM4C_uc011lmk.1_Silent_p.H389H|KDM4C_uc011lml.1_Silent_p.H331H	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	644					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						TGAAGCCACACTGTGCCATCT	0.517			NA											36	6					0	0	0.005524	0	0
PTPRD	5789	broad.mit.edu	37	9	8485268	8485268	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:8485268A>T	uc003zkk.2	-	28	3823	c.3112T>A	c.(3112-3114)TGG>AGG	p.W1038R	PTPRD_uc003zkp.2_Missense_Mutation_p.W627R|PTPRD_uc003zkq.2_Missense_Mutation_p.W627R|PTPRD_uc003zkr.2_Missense_Mutation_p.W622R|PTPRD_uc003zks.2_Missense_Mutation_p.W617R|PTPRD_uc003zkl.2_Missense_Mutation_p.W1029R|PTPRD_uc003zkm.2_Missense_Mutation_p.W1025R|PTPRD_uc003zkn.2_Missense_Mutation_p.W627R|PTPRD_uc003zko.2_Missense_Mutation_p.W624R	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1038	Fibronectin type-III 8.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGAATCTCCCAAGACAGCAAC	0.343			NA								TSP Lung(15;0.13)			19	2					0	0	0.010504	0	0
CNTLN	54875	broad.mit.edu	37	9	17464561	17464561	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:17464561G>C	uc003zmz.2	+	21	3494	c.3468G>C	c.(3466-3468)CAG>CAC	p.Q1156H	CNTLN_uc003zmy.2_Missense_Mutation_p.Q1157H|CNTLN_uc010mio.2_Missense_Mutation_p.Q836H	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1157	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		AATTTCGACAGAAAGTAAATT	0.289			NA											65	15					0	0	0.00361	0	0
IFNA5	3442	broad.mit.edu	37	9	21304946	21304946	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:21304946G>A	uc011lnh.1	-	1	310	c.310C>T	c.(310-312)CTT>TTT	p.L104F		NM_002169	NP_002160	P01569	IFNA5_HUMAN	interferon, alpha 5 precursor	104					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			ovary(1)	1				Lung(24;2.34e-24)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TTGTCTAGAAGTGTCTCATCC	0.473			NA											44	57					0	0	0.009718	0	0
PLAA	9373	broad.mit.edu	37	9	26920328	26920328	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:26920328T>C	uc003zqd.2	-	8	1519	c.1094A>G	c.(1093-1095)TAT>TGT	p.Y365C	PLAA_uc003zqe.2_Missense_Mutation_p.Y365C	NM_001031689	NP_001026859	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	365					phospholipid metabolic process|signal transduction		phospholipase A2 activator activity				0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		ACTCCACTGATAGGCTTCGAC	0.383	Melanoma(175;2670 2735 14091 35526)		NA											14	23					0	0	0.001855	0	0
TAF1L	138474	broad.mit.edu	37	9	32633952	32633952	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:32633952G>T	uc003zrg.1	-	1	1716	c.1626C>A	c.(1624-1626)AAC>AAA	p.N542K	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	542					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGGAGGGGGAGTTAGAGGTGG	0.488			NA											62	120					8.72158e-25	1.38032e-24	0.00361	1	0
SMU1	55234	broad.mit.edu	37	9	33057642	33057642	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:33057642C>A	uc003zsf.1	-	7	929	c.821G>T	c.(820-822)AGA>ATA	p.R274I	SMU1_uc010mjo.1_Missense_Mutation_p.R274I|SMU1_uc010mjp.1_Missense_Mutation_p.R274I|SMU1_uc011lnu.1_Missense_Mutation_p.R113I	NM_018225	NP_060695	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog	274	WD 2.					cytoplasm|nucleus				ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		TTCTGTATCTCTGCTGAAACA	0.398			NA											71	50					7.07328e-35	1.22032e-34	0.00361	1	0
NFX1	4799	broad.mit.edu	37	9	33318727	33318727	+	Splice_Site	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:33318727A>G	uc003zsq.2	+	8	1650	c.1589_splice	c.e8-2	p.V530_splice	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Splice_Site_p.V530_splice|NFX1_uc003zso.2_Splice_Site_p.V530_splice|NFX1_uc003zsp.1_Splice_Site_p.V530_splice|NFX1_uc010mjr.1_Splice_Site_p.V530_splice|NFX1_uc003zsr.2_Splice_Site_p.V530_splice	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1						inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		TTTCTCTTCAAGTATGCTATT	0.388			NA											55	60					0	0	0.00361	0	0
ALDH1B1	219	broad.mit.edu	37	9	38396171	38396171	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:38396171C>T	uc004aay.2	+	2	538	c.426C>T	c.(424-426)GTC>GTT	p.V142V		NM_000692	NP_000683	P30837	AL1B1_HUMAN	aldehyde dehydrogenase 1B1 precursor	142					carbohydrate metabolic process	mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity			skin(1)	1				GBM - Glioblastoma multiforme(29;0.043)|Lung(182;0.115)	NADH(DB00157)	TGGATGAGGTCATCAAGGTGT	0.557			NA											48	105					0	0	0.00361	0	0
FAM75A6	389730	broad.mit.edu	37	9	43625384	43625384	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:43625384G>T	uc011lrb.1	-	4	3332	c.3303C>A	c.(3301-3303)CCC>CCA	p.P1101P		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1101						integral to membrane					0						TGTGAATAGGGGGAAACATTG	0.478			NA											47	365					1.58458e-29	2.62828e-29	0.00361	1	0
FAM75A6	389730	broad.mit.edu	37	9	43627789	43627789	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:43627789C>T	uc011lrb.1	-	4	927	c.898G>A	c.(898-900)GAT>AAT	p.D300N		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	300						integral to membrane					0						GAAAGAGGATCTTGCTGGACT	0.552			NA											151	647					0	0	0.00361	0	0
FAM75A6	389730	broad.mit.edu	37	9	43627791	43627791	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:43627791T>G	uc011lrb.1	-	4	925	c.896A>C	c.(895-897)CAA>CCA	p.Q299P		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	299						integral to membrane					0						AAGAGGATCTTGCTGGACTGA	0.557			NA											146	635					0	0	0.00361	0	0
ANKRD20A3	441425	broad.mit.edu	37	9	67968449	67968449	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:67968449A>T	uc004aeu.2	+	15	2120	c.2008A>T	c.(2008-2010)AAA>TAA	p.K670*	ANKRD20A3_uc010mnn.2_Nonsense_Mutation_p.K669*	NM_001012419	NP_001012419	Q5VUR7	A20A3_HUMAN	ankyrin repeat domain 20 family, member A3	670	Potential.										0						AACACAAATTAAATTCAATGC	0.338			NA											52	45					0	0	0.00361	0	0
PGM5	5239	broad.mit.edu	37	9	71114172	71114172	+	Silent	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:71114172A>T	uc004agr.2	+	10	1738	c.1509A>T	c.(1507-1509)TCA>TCT	p.S503S		NM_021965	NP_068800	Q15124	PGM5_HUMAN	phosphoglucomutase 5	503					cell adhesion|cellular calcium ion homeostasis|glucose metabolic process	costamere|dystrophin-associated glycoprotein complex|focal adhesion|intercalated disc|internal side of plasma membrane|sarcolemma|spot adherens junction|stress fiber|Z disc	intramolecular transferase activity, phosphotransferases|magnesium ion binding|structural molecule activity			ovary(1)|pancreas(1)	2						CGGATGCATCACGGCTCATCT	0.527			NA											80	23					0	0	0.00361	0	0
TMEM2	23670	broad.mit.edu	37	9	74337423	74337423	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:74337423T>A	uc011lsa.1	-	12	2727	c.2187A>T	c.(2185-2187)TTA>TTT	p.L729F	TMEM2_uc010mos.2_Missense_Mutation_p.L666F|TMEM2_uc011lsb.1_RNA	NM_013390	NP_037522	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2 isoform a	729	PbH1 2.					integral to membrane				ovary(2)	2		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		TGTCAATAAATAAGCCAGCCT	0.353			NA											23	8					0	0	0.004656	0	0
VPS13A	23230	broad.mit.edu	37	9	79955112	79955112	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:79955112G>T	uc004akr.2	+	49	7053	c.6793G>T	c.(6793-6795)GAT>TAT	p.D2265Y	VPS13A_uc004akp.3_Missense_Mutation_p.D2265Y|VPS13A_uc004akq.3_Missense_Mutation_p.D2265Y|VPS13A_uc004aks.2_Missense_Mutation_p.D2226Y	NM_033305	NP_150648	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13A isoform A	2265					Golgi to endosome transport|protein transport	intracellular	protein binding			pancreas(3)|skin(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)	10						TATGGTAACTGATAGTGAGTT	0.318			NA											40	4					1.62957e-23	2.5314e-23	0.00874	1	0
SLC28A3	64078	broad.mit.edu	37	9	86903039	86903039	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:86903039C>A	uc010mpz.2	-	12	1329	c.1204G>T	c.(1204-1206)GCT>TCT	p.A402S	SLC28A3_uc011lsy.1_Missense_Mutation_p.A333S|SLC28A3_uc004anu.1_Missense_Mutation_p.A402S	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	402	Helical; (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TTAGCAGCAGCCAATGACGCA	0.428	Ovarian(106;425 1539 34835 42413 43572)		NA											96	21					7.34945e-47	1.32716e-46	0.00361	1	0
NTRK2	4915	broad.mit.edu	37	9	87636305	87636305	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:87636305C>A	uc004aoa.1	+	20	3360	c.2422C>A	c.(2422-2424)CAG>AAG	p.Q808K	NTRK2_uc004anz.1_Missense_Mutation_p.Q824K	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	808	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						TACCCTCCTTCAGAACTTGGC	0.592			NA								TSP Lung(25;0.17)			63	3					2.37532e-16	3.27199e-16	0.00361	1	0
DAPK1	1612	broad.mit.edu	37	9	90322028	90322028	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:90322028G>T	uc004apc.2	+	26	4180	c.4042G>T	c.(4042-4044)GGG>TGG	p.G1348W	DAPK1_uc004apd.2_Missense_Mutation_p.G1348W|DAPK1_uc011ltg.1_Missense_Mutation_p.G1282W|DAPK1_uc011lth.1_Missense_Mutation_p.G1085W|DAPK1_uc004apg.2_Missense_Mutation_p.G325W	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	1348	Death.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CACCAGTAACGGGGCTCCCAA	0.632			NA							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				56	18					9.04393e-38	1.57434e-37	0.00361	1	0
PTCH1	5727	broad.mit.edu	37	9	98220396	98220396	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:98220396C>A	uc004avk.3	-	18	3255	c.3067G>T	c.(3067-3069)GGC>TGC	p.G1023C	PTCH1_uc010mro.2_Missense_Mutation_p.G872C|PTCH1_uc010mrp.2_Missense_Mutation_p.G872C|PTCH1_uc010mrq.2_Missense_Mutation_p.G872C|PTCH1_uc004avl.3_Missense_Mutation_p.G872C|PTCH1_uc010mrr.2_Missense_Mutation_p.G957C|PTCH1_uc004avm.3_Missense_Mutation_p.G1022C	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	1023	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.I963fs*2(1)		skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				TGGCGGAGGCCGATGTACTGC	0.577			NA							Basal_Cell_Nevus_syndrome				46	12					5.48756e-27	8.88113e-27	0.002852	1	0
C9orf102	375748	broad.mit.edu	37	9	98643552	98643552	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:98643552A>T	uc004avt.3	+	2	869	c.481A>T	c.(481-483)ATG>TTG	p.M161L	C9orf102_uc010mrx.1_RNA|C9orf102_uc011lum.1_5'UTR|C9orf102_uc010mry.1_5'UTR|C9orf102_uc010mrz.2_5'UTR	NM_001010895	NP_001010895	Q5T890	RAD26_HUMAN	RAD26L hypothetical protein	161	ATP (By similarity).|Helicase ATP-binding.				DNA repair	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding				0		Acute lymphoblastic leukemia(62;0.0559)				GGGTGATGACATGGGACTTGG	0.363			NA											27	6					0	0	0.002096	0	0
GABBR2	9568	broad.mit.edu	37	9	101147957	101147957	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:101147957A>T	uc004ays.2	-	11	1783	c.1627T>A	c.(1627-1629)TTT>ATT	p.F543I		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	543	Helical; Name=2; (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	TCAGAGACAAAGGATCCATCA	0.428			NA											30	7					0	0	0.002836	0	0
CYLC2	1539	broad.mit.edu	37	9	105767812	105767812	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:105767812C>G	uc004bbs.2	+	5	969	c.899C>G	c.(898-900)GCC>GGC	p.A300G		NM_001340	NP_001331	Q14093	CYLC2_HUMAN	cylicin 2	300	31 X 3 AA repeats of K-K-X.				cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			skin(1)	1		all_hematologic(171;0.125)				acgaaagatgccaagaaagtt	0.144			NA											12	3					0	0	0.000978	0	0
SMC2	10592	broad.mit.edu	37	9	106889718	106889718	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:106889718A>T	uc004bbv.2	+	20	3035	c.2747A>T	c.(2746-2748)AAC>ATC	p.N916I	SMC2_uc004bbw.2_Missense_Mutation_p.N916I|SMC2_uc011lvl.1_Missense_Mutation_p.N916I|SMC2_uc004bbx.2_Missense_Mutation_p.N916I|SMC2_uc004bby.2_RNA	NM_001042551	NP_001036016	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	916	Potential.			N -> H (in Ref. 1; AAC72360).	cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			ovary(4)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|breast(1)	9						TTAGACCACAACATCAGCAAA	0.363			NA											28	5					0	0	0.009535	0	0
OR13C2	392376	broad.mit.edu	37	9	107367234	107367234	+	Silent	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:107367234G>A	uc011lvq.1	-	1	675	c.675C>T	c.(673-675)ATC>ATT	p.I225I		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C,	225	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						TAATTTTGAAGATGCTCACAA	0.408			NA											59	7					0	0	0.00361	0	0
OR13C9	286362	broad.mit.edu	37	9	107380040	107380040	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:107380040C>A	uc011lvr.1	-	1	446	c.446G>T	c.(445-447)TGG>TTG	p.W149L		NM_001001956	NP_001001956	Q8NGT0	O13C9_HUMAN	olfactory receptor, family 13, subfamily C,	149	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CCCTGCAAACCAGGACCCAAC	0.443			NA											56	14					4.78724e-31	8.05089e-31	0.00361	1	0
OR13D1	286365	broad.mit.edu	37	9	107457184	107457184	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:107457184C>G	uc011lvs.1	+	1	482	c.482C>G	c.(481-483)CCA>CGA	p.P161R		NM_001004484	NP_001004484	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D,	161	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						ATCTGCAACCCACTGAGGTAC	0.537			NA											73	23					0	0	0.00361	0	0
ASTN2	23245	broad.mit.edu	37	9	119625893	119625893	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:119625893G>T	uc004bjs.1	-	11	2110	c.2009C>A	c.(2008-2010)TCT>TAT	p.S670Y	ASTN2_uc004bjr.1_Missense_Mutation_p.S666Y|ASTN2_uc004bjt.1_Missense_Mutation_p.S619Y	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	670	Extracellular (Potential).|EGF-like 2.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CTGCCGGTCAGACACACACTT	0.577			NA											20	9					6.44725e-10	7.81755e-10	0.002299	1	0
TLR4	7099	broad.mit.edu	37	9	120475273	120475273	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:120475273A>G	uc004bjz.2	+	3	1158	c.867A>G	c.(865-867)CGA>CGG	p.R289R	TLR4_uc004bka.2_Silent_p.R249R|TLR4_uc004bkb.2_Silent_p.R89R	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	289	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						AAGAATTCCGATTAGCATACT	0.363			NA											26	9					0	0	0.005443	0	0
DBC1	1620	broad.mit.edu	37	9	121930490	121930490	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:121930490C>A	uc004bkc.2	-	8	1614	c.1158G>T	c.(1156-1158)CAG>CAT	p.Q386H		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	386					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TTGCAAGCCACTGCTGAATTG	0.512			NA											11	2					0.00185496	0.00192979	0.001855	1	0
OR1L8	138881	broad.mit.edu	37	9	125330211	125330211	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:125330211G>T	uc004bmp.1	-	1	546	c.546C>A	c.(544-546)CTC>CTA	p.L182L		NM_001004454	NP_001004454	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)	3						GCACAGGGCTGAGGTCACAGA	0.463			NA											34	8					1.04594e-18	1.50621e-18	0.00623	1	0
CRB2	286204	broad.mit.edu	37	9	126129486	126129486	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:126129486G>T	uc004bnx.1	+	5	882	c.790G>T	c.(790-792)GAG>TAG	p.E264*	CRB2_uc004bnw.1_Nonsense_Mutation_p.E264*	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	264	Extracellular (Potential).|EGF-like 6.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GGACGAGGACGAGTGTGCATC	0.682			NA											66	11					3.13743e-37	5.44196e-37	0.00361	1	0
NUP214	8021	broad.mit.edu	37	9	134103702	134103702	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:134103702A>T	uc004cag.2	+	33	6169	c.6058A>T	c.(6058-6060)AGC>TGC	p.S2020C	NUP214_uc004cah.2_Missense_Mutation_p.S2010C|NUP214_uc004cai.2_Missense_Mutation_p.S1450C|NUP214_uc010mzg.2_RNA|NUP214_uc011mcg.1_Missense_Mutation_p.S846C	NM_005085	NP_005076	P35658	NU214_HUMAN	nucleoporin 214kDa	2020	Pro/Ser/Thr-rich.|11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			breast(7)|lung(3)|skin(3)|ovary(2)|central_nervous_system(1)	16	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGCAGCTGCCAGCGCAGGAGG	0.607	Pancreas(4;24 48 25510 30394 32571)		NA	T	DEK|SET|ABL1	AML|T-ALL								41	5					0	0	0.003214	0	0
NTNG2	84628	broad.mit.edu	37	9	135073628	135073628	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:135073628C>A	uc004cbh.2	+	3	1265	c.489C>A	c.(487-489)CCC>CCA	p.P163P		NM_032536	NP_115925	Q96CW9	NTNG2_HUMAN	netrin G2 precursor	163	Laminin N-terminal.				axonogenesis	anchored to plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		CCTGGCAGCCCTACCAGTTCT	0.677			NA											30	9					2.47511e-08	2.90288e-08	0.008361	1	0
SARDH	1757	broad.mit.edu	37	9	136529095	136529095	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:136529095C>G	uc004cep.3	-	21	2807	c.2673G>C	c.(2671-2673)GAG>GAC	p.E891D	SARDH_uc004ceo.2_Missense_Mutation_p.E891D|SARDH_uc011mdn.1_Missense_Mutation_p.E891D|SARDH_uc011mdo.1_Missense_Mutation_p.E723D|SARDH_uc004cen.2_Missense_Mutation_p.E341D	NM_001134707	NP_001128179	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase precursor	891					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity				0				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		CCCCCATTCTCTCCAGGGCAT	0.572			NA											33	17					0	0	0.002445	0	0
COL5A1	1289	broad.mit.edu	37	9	137630602	137630602	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:137630602G>T	uc004cfe.2	+	11	1824	c.1442G>T	c.(1441-1443)GGA>GTA	p.G481V		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	481	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		GGTCTTCCCGGACCTCCAGGA	0.562			NA											73	14					6.44082e-31	1.08036e-30	0.00361	1	0
COL5A1	1289	broad.mit.edu	37	9	137727020	137727020	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:137727020C>T	uc004cfe.2	+	65	5722	c.5340C>T	c.(5338-5340)CCC>CCT	p.P1780P	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1780	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACAACAACCCCTACATCCGCG	0.672			NA											19	7					0	0	0.007413	0	0
KIAA0649	9858	broad.mit.edu	37	9	138377399	138377399	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:138377399A>T	uc004cfr.1	+	4	1592	c.1043A>T	c.(1042-1044)AAG>ATG	p.K348M		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	348						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		AGGAGGGGAAAGCGAGTCATG	0.617			NA											58	15					0	0	0.00361	0	0
LHX3	8022	broad.mit.edu	37	9	139090759	139090759	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:139090759C>A	uc004cha.2	-	4	698	c.601G>T	c.(601-603)GTG>TTG	p.V201L	LHX3_uc004cgz.2_Missense_Mutation_p.V206L	NM_178138	NP_835258	Q9UBR4	LHX3_HUMAN	LIM homeobox protein 3 isoform a	201	Homeobox.				inner ear development|organ morphogenesis|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1		Myeloproliferative disorder(178;0.0511)		Epithelial(140;8.43e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.26e-07)		CTGACCTGCACCACGCGCATG	0.741			NA											27	1					4.87955e-14	6.38502e-14	0.005443	1	0
FAM69B	138311	broad.mit.edu	37	9	139617948	139617948	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:139617948T>A	uc004cik.2	+	5	1112	c.1018T>A	c.(1018-1020)TGC>AGC	p.C340S	FAM69B_uc004cil.2_Missense_Mutation_p.C253S|SNHG7_uc004cim.2_Intron	NM_152421	NP_689634	Q5VUD6	FA69B_HUMAN	hypothetical protein LOC138311	340	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane					0	all_cancers(76;0.0882)|all_epithelial(76;0.228)	Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;1.03e-05)|Epithelial(140;0.00013)		CAGCACCGACTGCACCTACGG	0.682			NA											13	0					0	0	0.001368	0	0
ABCA2	20	broad.mit.edu	37	9	139912785	139912785	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:139912785C>T	uc011mem.1	-	13	1983	c.1835G>A	c.(1834-1836)CGG>CAG	p.R612Q	ABCA2_uc011mel.1_Missense_Mutation_p.R613Q|ABCA2_uc004ckl.1_Missense_Mutation_p.R543Q|ABCA2_uc004ckm.1_Missense_Mutation_p.R643Q|ABCA2_uc004ckn.1_RNA|ABCA2_uc004cko.1_Missense_Mutation_p.R389Q	NM_001606	NP_001597	Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A, member 2	612					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances				0	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GCCGTCCTTCCGGGTCTGGAA	0.408			NA											46	5					0	0	0.00361	0	0
SHOX	6473	broad.mit.edu	37	X	591819	591819	+	Missense_Mutation	SNP	G	G	T	rs138243769		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:591819G>T	uc004cph.1	+	2	878	c.187G>T	c.(187-189)GGC>TGC	p.G63C	SHOX_uc004cpi.2_Missense_Mutation_p.G63C	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	63					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACGGAGGGCGGCGGCCACTG	0.582	Ovarian(95;18 1419 12424 14056 28266)		NA											52	20					7.05377e-20	1.03663e-19	0.00361	1	0
P2RY8	286530	broad.mit.edu	37	X	1584744	1584744	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:1584744C>A	uc004cpz.2	-	2	956	c.708G>T	c.(706-708)GTG>GTT	p.V236V		NM_178129	NP_835230	Q86VZ1	P2RY8_HUMAN	G-protein coupled purinergic receptor P2Y8	236	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			lung(5)	5		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CGGCCAGGCCCACCGCGCGCC	0.657			NA	T	CRLF2	B-ALL|Downs associated ALL								13	7					2.27111e-07	2.59901e-07	0.001368	1	0
MXRA5	25878	broad.mit.edu	37	X	3238188	3238188	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:3238188G>T	uc004crg.3	-	5	5695	c.5538C>A	c.(5536-5538)TTC>TTA	p.F1846L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1846						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CAAGAGACCAGAATTTGGATG	0.507			NA											25	7					3.28513e-13	4.2328e-13	0.003954	1	0
MXRA5	25878	broad.mit.edu	37	X	3242201	3242201	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:3242201G>T	uc004crg.3	-	5	1682	c.1525C>A	c.(1525-1527)CCA>ACA	p.P509T		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	509	Ig-like C2-type 1.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAGATAGATGGACTCTCAGAA	0.532			NA											58	9					1.0442e-30	1.74695e-30	0.00361	1	0
PRPS2	5634	broad.mit.edu	37	X	12817345	12817345	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:12817345G>T	uc004cvb.2	+	2	266	c.142G>T	c.(142-144)GTG>TTG	p.V48L	PRPS2_uc004cva.2_Missense_Mutation_p.V48L|PRPS2_uc010nec.2_5'UTR	NM_002765	NP_002756	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	48					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity				0						TGGTGAAAGCGTGAGAGGGGA	0.393			NA											19	5					1.45105e-14	1.9182e-14	0.006122	1	0
FAM48B2	170067	broad.mit.edu	37	X	24330962	24330962	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:24330962A>G	uc011mjw.1	-	1	471	c.471T>C	c.(469-471)CCT>CCC	p.P157P		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	157											0						GGTAACCAGGAGGTTGCATAT	0.468			NA											32	10					0	0	0.00361	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212836	26212836	+	Silent	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:26212836C>G	uc004dbr.2	+	2	1022	c.873C>G	c.(871-873)CTC>CTG	p.L291L	MAGEB6_uc010ngc.1_Silent_p.L71L	NM_173523	NP_775794	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	291	MAGE.									ovary(3)	3						TGATGTCGCTCCTGGTTGTGA	0.542			NA											78	19					0	0	0.00361	0	0
MAGEB10	139422	broad.mit.edu	37	X	27839475	27839475	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:27839475G>T	uc004dbw.2	+	3	279	c.52G>T	c.(52-54)GCC>TCC	p.A18S		NM_182506	NP_872312	Q96LZ2	MAGBA_HUMAN	melanoma antigen family B, 10	18										lung(1)|breast(1)|central_nervous_system(1)	3						ACGCCGTCAGGCCCGAGGAGG	0.522			NA											13	6					3.27435e-08	3.81942e-08	0.00245	1	0
DCAF8L1	139425	broad.mit.edu	37	X	27998429	27998429	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:27998429A>G	uc004dbx.1	-	1	1138	c.1023T>C	c.(1021-1023)TCT>TCC	p.S341S		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	341	WD 4.									ovary(3)|skin(1)	4						CAGGATTCATAGAGATTGTAT	0.403			NA											7	13					0	0	0.001984	0	0
DMD	1756	broad.mit.edu	37	X	32717412	32717412	+	Splice_Site	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:32717412T>C	uc004dda.1	-	8	894	c.650_splice	c.e8-1	p.D217_splice	DMD_uc004dcz.2_Splice_Site_p.D94_splice|DMD_uc004dcy.1_Splice_Site_p.D213_splice|DMD_uc004ddb.1_Splice_Site_p.D209_splice|DMD_uc010ngo.1_Intron|DMD_uc004ddf.2_Splice_Site_p.D209_splice|DMD_uc010ngp.1_Intron|DMD_uc010ngq.1_Intron|DMD_uc010ngr.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform						muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TATCAACATCTGTAAGCACAT	0.353			NA											8	6					0	0	0.004482	0	0
FAM47A	158724	broad.mit.edu	37	X	34149284	34149284	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:34149284C>A	uc004ddg.2	-	1	1145	c.1112G>T	c.(1111-1113)CGG>CTG	p.R371L		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	371										ovary(4)|central_nervous_system(1)	5						ACTGGACCCCCGACGAGTCTT	0.642			NA											25	6					1.36565e-18	1.96369e-18	0.00278	1	0
FAM47A	158724	broad.mit.edu	37	X	34149686	34149686	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:34149686G>T	uc004ddg.2	-	1	743	c.710C>A	c.(709-711)CCG>CAG	p.P237Q		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	237	Pro-rich.									ovary(4)|central_nervous_system(1)	5						TGGAGGCTCCGGGCGGAGATG	0.632			NA											28	5					3.73148e-12	4.73846e-12	0.007291	1	0
FAM47A	158724	broad.mit.edu	37	X	34150015	34150015	+	Silent	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:34150015G>T	uc004ddg.2	-	1	414	c.381C>A	c.(379-381)GCC>GCA	p.A127A		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	127										ovary(4)|central_nervous_system(1)	5						AGGGATGCTTGGCCATTAGCT	0.542			NA											32	6					1.22384e-17	1.73272e-17	0.002836	1	0
MED14	9282	broad.mit.edu	37	X	40531114	40531114	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:40531114T>C	uc004dex.3	-	23	3272	c.3132A>G	c.(3130-3132)CCA>CCG	p.P1044P		NM_004229	NP_004220	O60244	MED14_HUMAN	mediator complex subunit 14	1044	Pro-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(2)|kidney(1)|skin(1)	4						ATATCTTACCTGGAGACTGTG	0.433			NA											61	9					0	0	0.00361	0	0
ZNF182	7569	broad.mit.edu	37	X	47836120	47836120	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:47836120T>A	uc004dir.2	-	7	1712	c.1366A>T	c.(1366-1368)AAA>TAA	p.K456*	ZNF182_uc004dis.2_Nonsense_Mutation_p.K437*|ZNF182_uc004dit.2_Nonsense_Mutation_p.K456*|ZNF182_uc011mlu.1_Nonsense_Mutation_p.K436*	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						TCAAAGGGTTTCTCTCCTGAA	0.428			NA											16	4					0	0	0.003163	0	0
ZNF182	7569	broad.mit.edu	37	X	47836531	47836531	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:47836531C>A	uc004dir.2	-	7	1301	c.955G>T	c.(955-957)GAA>TAA	p.E319*	ZNF182_uc004dis.2_Nonsense_Mutation_p.E300*|ZNF182_uc004dit.2_Nonsense_Mutation_p.E319*|ZNF182_uc011mlu.1_Nonsense_Mutation_p.E299*	NM_006962	NP_008893	P17025	ZN182_HUMAN	zinc finger protein 21 isoform 1	319	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3						TCATTACATTCATAAGGTTTT	0.418			NA											17	5					1.37522e-17	1.93996e-17	0.007413	1	0
SSX1	6756	broad.mit.edu	37	X	48121245	48121245	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:48121245C>A	uc004djb.1	+	5	416	c.325C>A	c.(325-327)CCG>ACG	p.P109T		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						CAGAATCATCCCGAAGGTGAG	0.408	Esophageal Squamous(175;994 1982 2214 6527 18857)		NA											15	3					2.85442e-18	4.08015e-18	0.002096	1	0
SSX1	6756	broad.mit.edu	37	X	48121247	48121247	+	Silent	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:48121247G>C	uc004djb.1	+	5	418	c.327G>C	c.(325-327)CCG>CCC	p.P109P		NM_005635	NP_005626	Q16384	SSX1_HUMAN	synovial sarcoma, X breakpoint 1	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|transcription corepressor activity		SS18/SSX1(1169)	soft_tissue(1169)	1169						GAATCATCCCGAAGGTGAGTA	0.408	Esophageal Squamous(175;994 1982 2214 6527 18857)		NA											13	3					0	0	0.009535	0	0
SLC38A5	92745	broad.mit.edu	37	X	48320401	48320401	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:48320401C>A	uc010nid.2	-	11	941	c.763G>T	c.(763-765)GAC>TAC	p.D255Y	SLC38A5_uc004djk.3_Missense_Mutation_p.D204Y	NM_033518	NP_277053	Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	255	Extracellular (Potential).				cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				ovary(3)	3						ACCTGTGAGTCAACTGTGAAC	0.527			NA											8	2					5.18039e-06	5.70876e-06	0.00308	1	0
GATA1	2623	broad.mit.edu	37	X	48650612	48650612	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:48650612C>A	uc004dkq.3	+	3	673	c.582C>A	c.(580-582)CTC>CTA	p.L194L		NM_002049	NP_002040	P15976	GATA1_HUMAN	GATA binding protein 1	194					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(2)|p.V74_C199del(1)		haematopoietic_and_lymphoid_tissue(246)|lung(2)	248						GTGGAACTCTCCCCCTGCCTC	0.552	Pancreas(9;429 505 11287 29617)		NA	Mis|F		megakaryoblastic leukemia of Downs Syndrome								23	6					3.83957e-06	4.24813e-06	0.00278	1	0
CCNB3	85417	broad.mit.edu	37	X	50053609	50053609	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:50053609G>T	uc004dox.3	+	6	2738	c.2440G>T	c.(2440-2442)GCT>TCT	p.A814S	CCNB3_uc004doy.2_Missense_Mutation_p.A814S|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	814					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					TGAGAAGGAAGCTGTCCTCAA	0.567			NA											8	2					2.17888e-05	2.37539e-05	0.006214	1	0
WNK3	65267	broad.mit.edu	37	X	54282275	54282275	+	Silent	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:54282275A>G	uc004dtd.1	-	12	2587	c.2148T>C	c.(2146-2148)CCT>CCC	p.P716P	WNK3_uc004dtc.1_Silent_p.P716P	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	716					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						TTGGGTTATCAGGGCTACTGA	0.418			NA											3	38					0	0	0.009096	0	0
ALAS2	212	broad.mit.edu	37	X	55042087	55042087	+	Silent	SNP	C	C	G	rs150494562	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:55042087C>G	uc004dua.3	-	8	1230	c.1092G>C	c.(1090-1092)CTG>CTC	p.L364L	ALAS2_uc004dub.3_Silent_p.L351L|ALAS2_uc004dud.3_Silent_p.L327L	NM_000032	NP_000023	P22557	HEM0_HUMAN	5-aminolevulinate synthase 2 isoform a	364					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(1)	1					Glycine(DB00145)	GGGACCCATACAGTCCTACAG	0.542			NA											23	10					0	0	0.001882	0	0
USP51	158880	broad.mit.edu	37	X	55513961	55513961	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:55513961C>A	uc004dun.1	-	2	1491	c.1412G>T	c.(1411-1413)GGG>GTG	p.G471V	USP51_uc011moo.1_Missense_Mutation_p.G175V	NM_201286	NP_958443	Q70EK9	UBP51_HUMAN	ubiquitin specific protease 51	471					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3						GGCCTCCTGCCCACCACTATC	0.468			NA											41	14					2.40228e-13	3.1077e-13	0.003214	1	0
MTMR8	55613	broad.mit.edu	37	X	63569932	63569932	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:63569932G>T	uc004dvs.2	-	5	555	c.487C>A	c.(487-489)CCT>ACT	p.P163T	MTMR8_uc011mou.1_Missense_Mutation_p.P163T|MTMR8_uc004dvt.1_Missense_Mutation_p.P163T	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	163	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						ACTATTTCAGGAGGGTAGGTG	0.343			NA											26	6					9.39395e-14	1.22343e-13	0.00632	1	0
NHSL2	340527	broad.mit.edu	37	X	71360027	71360027	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:71360027G>T	uc011mqa.1	+	6	2629	c.2629G>T	c.(2629-2631)GTG>TTG	p.V877L	NHSL2_uc004eak.1_Missense_Mutation_p.V511L|NHSL2_uc010nli.2_Missense_Mutation_p.V646L	NM_001013627	NP_001013649	Q5HYW2	NHSL2_HUMAN	NHS-like 2	877											0	Renal(35;0.156)					GAAGCCTCCGGTGGCCCGGAG	0.547			NA											21	8					1.50039e-11	1.88181e-11	0.001882	1	0
CDX4	1046	broad.mit.edu	37	X	72667208	72667208	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:72667208C>G	uc011mqk.1	+	1	119	c.119C>G	c.(118-120)CCA>CGA	p.P40R		NM_005193	NP_005184	O14627	CDX4_HUMAN	caudal type homeobox 4	40						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Renal(35;0.156)					AGTCCGATGCCAGCCTCCAAT	0.632			NA											12	2					0	0	0.000978	0	0
MAGEE1	57692	broad.mit.edu	37	X	75649313	75649313	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:75649313C>T	uc004ecm.1	+	1	1197	c.990C>T	c.(988-990)ACC>ACT	p.T330T		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	330	Pro-rich.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						GACTGAGCACCTCCGTGCCGC	0.706			NA											15	3					0	0	0.004007	0	0
CYSLTR1	10800	broad.mit.edu	37	X	77528879	77528879	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:77528879C>A	uc004edb.2	-	3	765	c.365G>T	c.(364-366)TGC>TTC	p.C122F	CYSLTR1_uc010nma.2_Missense_Mutation_p.C122F|CYSLTR1_uc010nmb.2_Missense_Mutation_p.C122F	NM_006639	NP_006630	Q9Y271	CLTR1_HUMAN	cysteinyl leukotriene receptor 1	122	Helical; Name=3; (Potential).				elevation of cytosolic calcium ion concentration|respiratory gaseous exchange	integral to plasma membrane|membrane fraction	leukotriene receptor activity			ovary(1)	1					Amlexanox(DB01025)|Cinalukast(DB00587)|Montelukast(DB00471)|Nedocromil(DB00716)|Pranlukast(DB01411)|Zafirlukast(DB00549)	AATTGCAATGCACCGGAAAAA	0.408			NA											9	3					7.48243e-07	8.41338e-07	0.006214	1	0
TBX22	50945	broad.mit.edu	37	X	79286084	79286084	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:79286084C>G	uc010nmg.1	+	9	1171	c.1037C>G	c.(1036-1038)CCT>CGT	p.P346R	TBX22_uc004edi.1_Missense_Mutation_p.P226R|TBX22_uc004edj.1_Missense_Mutation_p.P346R	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	346					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TGCTTTTCACCTATGTTTCAT	0.483			NA											39	7					0	0	0.004878	0	0
BRWD3	254065	broad.mit.edu	37	X	79947450	79947450	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:79947450C>G	uc004edt.2	-	30	3616	c.3353G>C	c.(3352-3354)GGT>GCT	p.G1118A	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G714A|BRWD3_uc004edp.2_Missense_Mutation_p.G947A|BRWD3_uc004edq.2_Missense_Mutation_p.G714A|BRWD3_uc010nmj.1_Missense_Mutation_p.G714A|BRWD3_uc004edr.2_Missense_Mutation_p.G788A|BRWD3_uc004eds.2_Missense_Mutation_p.G714A|BRWD3_uc004edu.2_Missense_Mutation_p.G788A|BRWD3_uc004edv.2_Missense_Mutation_p.G714A|BRWD3_uc004edw.2_Missense_Mutation_p.G714A|BRWD3_uc004edx.2_Missense_Mutation_p.G714A|BRWD3_uc004edy.2_Missense_Mutation_p.G714A|BRWD3_uc004edz.2_Missense_Mutation_p.G788A|BRWD3_uc004eea.2_Missense_Mutation_p.G788A|BRWD3_uc004eeb.2_Missense_Mutation_p.G714A	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1118										ovary(4)	4						GACAGGAACACCAGCACCAAC	0.378			NA											6	3					0	0	0.001168	0	0
CPXCR1	53336	broad.mit.edu	37	X	88008694	88008694	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:88008694G>T	uc004efd.3	+	3	538	c.279G>T	c.(277-279)CAG>CAT	p.Q93H	CPXCR1_uc004efc.3_Missense_Mutation_p.Q93H	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	93						intracellular	zinc ion binding			ovary(3)	3						TTCTACTTCAGACCCCCATTC	0.413			NA											9	4					9.70103e-10	1.17042e-09	0.008291	1	0
PCDH11X	27328	broad.mit.edu	37	X	91134082	91134082	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:91134082T>A	uc004efk.1	+	2	3688	c.2843T>A	c.(2842-2844)TTC>TAC	p.F948Y	PCDH11X_uc004efl.1_Missense_Mutation_p.F948Y|PCDH11X_uc004efo.1_Missense_Mutation_p.F948Y|PCDH11X_uc010nmv.1_Missense_Mutation_p.F948Y|PCDH11X_uc004efm.1_Missense_Mutation_p.F948Y|PCDH11X_uc004efn.1_Missense_Mutation_p.F948Y|PCDH11X_uc004efh.1_Missense_Mutation_p.F948Y|PCDH11X_uc004efj.1_Missense_Mutation_p.F948Y	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	948	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						CAGCCTGCCTTCCAAATTCAG	0.488	NSCLC(38;925 1092 2571 38200 45895)		NA											63	24					0	0	0.00361	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382344	101382344	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:101382344G>A	uc004eip.2	+	3	761	c.542G>A	c.(541-543)AGG>AAG	p.R181K		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GAGGATAAAAGGAGAAAAAGC	0.433			NA											42	16					0	0	0.002522	0	0
TCEAL6	158931	broad.mit.edu	37	X	101396142	101396142	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:101396142T>A	uc004eiq.2	-	3	323	c.162A>T	c.(160-162)CCA>CCT	p.P54P		NM_001006938	NP_001006939	Q6IPX3	TCAL6_HUMAN	transcription elongation factor A (SII)-like 6	54	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						cctcatcacctggctctccct	0.264			NA											45	15					0	0	0.002522	0	0
GPRASP2	114928	broad.mit.edu	37	X	101972246	101972246	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:101972246G>T	uc004ejk.2	+	4	3783	c.2449G>T	c.(2449-2451)GAG>TAG	p.E817*	GPRASP2_uc004ejl.2_Nonsense_Mutation_p.E817*|GPRASP2_uc004ejm.2_Nonsense_Mutation_p.E817*|GPRASP2_uc011mrp.1_Nonsense_Mutation_p.E156*	NM_138437	NP_612446	Q96D09	GASP2_HUMAN	G protein-coupled receptor associated sorting	817						cytoplasm	protein binding			ovary(1)	1						TGAATTTGAGGAGTTAGCTAA	0.378			NA											36	7					1.60099e-16	2.20692e-16	0.004878	1	0
RAB40AL	282808	broad.mit.edu	37	X	102192749	102192749	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:102192749C>T	uc004ejs.2	+	1	550	c.503C>T	c.(502-504)ACG>ATG	p.T168M		NM_001031834	NP_001027004	P0C0E4	RB40L_HUMAN	RAB40A, member RAS oncogene family-like	168					protein transport|small GTPase mediated signal transduction	mitochondrion|plasma membrane	GTP binding			ovary(2)	2						GAGTCTTTCACGGAGCTGGCC	0.612			NA											16	3					0	0	0.003163	0	0
GLRA4	441509	broad.mit.edu	37	X	102979467	102979467	+	Splice_Site	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:102979467A>T	uc011mse.1	-	3	691	c.270_splice	c.e3+1	p.M90_splice	GLRA4_uc010nou.2_Splice_Site_p.M90_splice	NM_001024452	NP_001019623	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4 precursor							cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity				0						GAGATCCCTTACCATTGTGGT	0.542			NA											4	0					0	0	0.000602	0	0
PLP1	5354	broad.mit.edu	37	X	103040647	103040647	+	Silent	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:103040647T>A	uc010nov.2	+	3	421	c.141T>A	c.(139-141)ATT>ATA	p.I47I	RAB9B_uc004eli.1_Intron|PLP1_uc004elk.2_Silent_p.I47I|PLP1_uc004elj.2_Silent_p.I47I|PLP1_uc011msf.1_Intron|PLP1_uc010now.1_Silent_p.I51I|PLP1_uc010nox.2_5'Flank	NM_001128834	NP_001122306	P60201	MYPR_HUMAN	proteolipid protein 1 isoform 1	47	Extracellular (Probable).				cell death|synaptic transmission	integral to membrane				ovary(1)	1						AAAAGCTAATTGAGACCTATT	0.483			NA											68	18					0	0	0.00361	0	0
IRS4	8471	broad.mit.edu	37	X	107977509	107977509	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:107977509G>T	uc004eoc.2	-	1	2099	c.2066C>A	c.(2065-2067)GCC>GAC	p.A689D		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	689	CRK-binding.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						AAAAGCTCTGGCTCTGTGGGG	0.502			NA											106	17					6.36747e-66	1.18639e-65	0.00361	1	0
GUCY2F	2986	broad.mit.edu	37	X	108708535	108708535	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:108708535A>G	uc004eod.3	-	3	1144	c.868T>C	c.(868-870)TAT>CAT	p.Y290H	GUCY2F_uc011msq.1_RNA	NM_001522	NP_001513	P51841	GUC2F_HUMAN	guanylate cyclase 2F precursor	290	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			lung(4)|breast(3)|central_nervous_system(1)	8						GTGTGCTTATAAGGTAAACTG	0.468			NA											28	12					0	0	0.00361	0	0
PAK3	5063	broad.mit.edu	37	X	110463590	110463590	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:110463590C>A	uc004epa.2	+	15	1622	c.1595C>A	c.(1594-1596)CCA>CAA	p.P532Q	PAK3_uc010npt.1_Missense_Mutation_p.P517Q|PAK3_uc010npu.1_Missense_Mutation_p.P517Q|PAK3_uc004eoz.2_Missense_Mutation_p.P517Q|PAK3_uc011mst.1_RNA|PAK3_uc010npv.1_Missense_Mutation_p.P553Q|PAK3_uc010npw.1_Missense_Mutation_p.P538Q	NM_001128173	NP_001121645	O75914	PAK3_HUMAN	p21-activated kinase 3 isoform d	532	Protein kinase.				multicellular organismal development		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding			lung(6)|ovary(3)|large_intestine(1)	10						TTGCAGCATCCATTTTTAAAA	0.388			NA								TSP Lung(19;0.15)			6	5					0.00198382	0.00205832	0.001984	1	0
TRPC5	7224	broad.mit.edu	37	X	111090614	111090614	+	Silent	SNP	C	C	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:111090614C>T	uc004epl.1	-	6	2347	c.1428G>A	c.(1426-1428)CTG>CTA	p.L476L	TRPC5_uc004epm.1_Silent_p.L476L	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	476	Helical; (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						CTTCCGCAATCAGAGTCGGGT	0.453			NA											13	5					0	0	0.00245	0	0
TRPC5	7224	broad.mit.edu	37	X	111195290	111195290	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:111195290C>G	uc004epl.1	-	2	1278	c.359G>C	c.(358-360)CGG>CCG	p.R120P	TRPC5_uc004epm.1_Missense_Mutation_p.R120P	NM_012471	NP_036603	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel,	120	ANK 3.|Cytoplasmic (Potential).				axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			urinary_tract(1)	1						TCCGCTGGGCCGCCTGTAGCT	0.547			NA											46	6					0	0	0.002852	0	0
ZBTB33	10009	broad.mit.edu	37	X	119388873	119388873	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:119388873G>T	uc004esn.1	+	2	1831	c.1603G>T	c.(1603-1605)GAA>TAA	p.E535*	ZBTB33_uc010nqm.1_Nonsense_Mutation_p.E535*	NM_006777	NP_006768	Q86T24	KAISO_HUMAN	kaiso	535	C2H2-type 2.|Interaction with CTNND1 (By similarity).|Required for DNA-binding (By similarity).				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleolus|plasma membrane	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TCCTCTTGCAGAATATCGCAC	0.423			NA											42	9					1.23103e-26	1.98566e-26	0.003214	1	0
THOC2	57187	broad.mit.edu	37	X	122802161	122802161	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:122802161A>C	uc004etu.2	-	10	898	c.866T>G	c.(865-867)CTT>CGT	p.L289R	THOC2_uc011muh.1_Missense_Mutation_p.L210R|THOC2_uc011mui.1_Missense_Mutation_p.L174R	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	289					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						ATCAGCCGGAAGAAGCTAAAA	0.299			NA											35	14					0	0	0.002836	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185830	127185830	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:127185830C>A	uc004eum.2	-	1	553	c.356G>T	c.(355-357)CGA>CTA	p.R119L		NM_138289	NP_612146	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	119						cytoplasm|cytoskeleton				ovary(2)|central_nervous_system(2)|skin(1)	5						TAGCTTTTCTCGAATTTCCCT	0.488			NA											92	25					2.68325e-40	4.74786e-40	0.00361	1	0
FAM45B	55855	broad.mit.edu	37	X	129629754	129629754	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:129629754C>A	uc010nrh.2	+	1	840	c.622C>A	c.(622-624)CAG>AAG	p.Q208K	uc004evu.2_Intron	NM_207009	NP_996892			hypothetical protein LOC404636											skin(1)	1				all cancers(201;0.0293)		GTGGCACCGACAGGACTGGAC	0.537			NA											32	11					7.11191e-15	9.49891e-15	0.002836	1	0
TFDP3	51270	broad.mit.edu	37	X	132351734	132351734	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:132351734T>C	uc004exb.1	-	1	643	c.554A>G	c.(553-555)AAG>AGG	p.K185R		NM_016521	NP_057605	Q5H9I0	TFDP3_HUMAN	transcription factor Dp family, member 3	185	Potential.|Involved in negatively regulating E2F activity.|DEF box (By similarity).					transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ACCAATCCACTTGATCTTCTT	0.443			NA											15	5					0	0	0.00245	0	0
GPC4	2239	broad.mit.edu	37	X	132445320	132445320	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:132445320T>A	uc004exc.1	-	4	1055	c.843A>T	c.(841-843)CAA>CAT	p.Q281H	GPC4_uc011mvg.1_Missense_Mutation_p.Q211H	NM_001448	NP_001439	O75487	GPC4_HUMAN	glypican 4 precursor	281					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	Acute lymphoblastic leukemia(192;0.000127)					CGAGATCCCCTTGGTTGGCCA	0.453			NA											45	3					0	0	0.00361	0	0
SAGE1	55511	broad.mit.edu	37	X	134983781	134983781	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:134983781A>T	uc004ezh.2	+	3	318	c.151A>T	c.(151-153)AGA>TGA	p.R51*	SAGE1_uc010nry.1_Nonsense_Mutation_p.R51*|SAGE1_uc011mvv.1_Nonsense_Mutation_p.R51*	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	51										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GAAACATTCCAGAAAATCCAA	0.408			NA											77	14					0	0	0.00361	0	0
SAGE1	55511	broad.mit.edu	37	X	134990679	134990679	+	Silent	SNP	T	T	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:134990679T>C	uc004ezh.2	+	12	1511	c.1344T>C	c.(1342-1344)AAT>AAC	p.N448N	SAGE1_uc010nry.1_Silent_p.N417N|SAGE1_uc011mvv.1_Intron	NM_018666	NP_061136	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	448										ovary(2)|skin(1)	3	Acute lymphoblastic leukemia(192;0.000127)					GGATGGAAAATGGCCAACGAA	0.433			NA											34	7					0	0	0.002836	0	0
GPR112	139378	broad.mit.edu	37	X	135427303	135427303	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:135427303G>T	uc004ezu.1	+	6	1729	c.1438G>T	c.(1438-1440)GTA>TTA	p.V480L	GPR112_uc010nsb.1_Missense_Mutation_p.V275L|GPR112_uc010nsc.1_Missense_Mutation_p.V247L	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	480	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					AGCTGCTCCAGTAGATTCTGT	0.443			NA											35	4					3.66082e-28	6.00511e-28	0.005524	1	0
VGLL1	51442	broad.mit.edu	37	X	135618368	135618368	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:135618368G>T	uc004ezy.2	+	2	359	c.189G>T	c.(187-189)CAG>CAT	p.Q63H		NM_016267	NP_057351	Q99990	VGLL1_HUMAN	vestigial like 1	63					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity				0	Acute lymphoblastic leukemia(192;0.000127)					CCTCGAGTCAGAGTGAAGGTG	0.527			NA											30	7					1.13719e-10	1.39995e-10	0.008361	1	0
SOX3	6658	broad.mit.edu	37	X	139586651	139586651	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:139586651G>T	uc004fbd.1	-	1	575	c.575C>A	c.(574-576)GCC>GAC	p.A192D		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	192	HMG box.				face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					AAGTCGCTTGGCCTCGTCGAT	0.572			NA											24	5					2.39556e-15	3.23761e-15	0.00278	1	0
SLITRK4	139065	broad.mit.edu	37	X	142716747	142716747	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:142716747G>T	uc004fbx.2	-	2	2554	c.2178C>A	c.(2176-2178)GAC>GAA	p.D726E	SLITRK4_uc004fby.2_Missense_Mutation_p.D726E	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	726	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTTTCTCCTTGTCGGCCACAT	0.418			NA											37	17					3.93418e-24	6.1609e-24	0.004289	1	0
SLITRK2	84631	broad.mit.edu	37	X	144905527	144905527	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:144905527G>T	uc004fcd.2	+	5	2574	c.1584G>T	c.(1582-1584)GAG>GAT	p.E528D	SLITRK2_uc010nsp.2_Missense_Mutation_p.E528D|SLITRK2_uc010nso.2_Missense_Mutation_p.E528D|SLITRK2_uc011mwq.1_Missense_Mutation_p.E528D|SLITRK2_uc011mwr.1_Missense_Mutation_p.E528D|SLITRK2_uc011mws.1_Missense_Mutation_p.E528D|SLITRK2_uc004fcg.2_Missense_Mutation_p.E528D|SLITRK2_uc011mwt.1_Missense_Mutation_p.E528D	NM_032539	NP_115928	Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2 precursor	528	Extracellular (Potential).					integral to membrane				ovary(5)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					ATCTGCAGGAGAACCCCTGGG	0.507			NA											27	5					1.2476e-16	1.72347e-16	0.00632	1	0
MAGEA11	4110	broad.mit.edu	37	X	148797834	148797834	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:148797834G>C	uc004fdq.2	+	5	790	c.688G>C	c.(688-690)GTT>CTT	p.V230L	HSFX2_uc004fdl.2_Intron|HSFX1_uc004fdm.2_Intron|MAGEA11_uc004fdr.2_Missense_Mutation_p.V201L	NM_005366	NP_005357	P43364	MAGAB_HUMAN	melanoma antigen family A, 11 isoform a	230	MAGE.					cytoplasm|nucleus	protein binding			ovary(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					AATTGATTTGGTTCATTTATT	0.453			NA											39	12					0	0	0.007835	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303310	151303310	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:151303310G>C	uc004ffk.2	-	5	1191	c.783C>G	c.(781-783)CAC>CAG	p.H261Q	MAGEA10_uc004ffl.2_Missense_Mutation_p.H261Q	NM_001011543	NP_001011543	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	261	MAGE.										0	Acute lymphoblastic leukemia(192;6.56e-05)					CATAAATGAGGTGCTCCATCC	0.532			NA											34	14					0	0	0.002836	0	0
GABRQ	55879	broad.mit.edu	37	X	151821301	151821301	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:151821301G>T	uc004ffp.1	+	9	1476	c.1456G>T	c.(1456-1458)GTC>TTC	p.V486F		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	486						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CCGCAACCGTGTCGAAGCCCA	0.552			NA											52	14					2.12129e-23	3.28468e-23	0.00361	1	0
ZNF275	10838	broad.mit.edu	37	X	152612393	152612393	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:152612393G>C	uc004fhg.1	+	4	427	c.250G>C	c.(250-252)GAC>CAC	p.D84H	ZNF275_uc011mym.1_Missense_Mutation_p.D84H|ZNF275_uc011myn.1_Missense_Mutation_p.D21H			A6NFS0	A6NFS0_HUMAN	SubName: Full=cDNA FLJ16723 fis, clone UTERU3004418, highly similar to Zinc finger protein 275; SubName: Full=Putative uncharacterized protein ZNF275;	84						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACAGCACGGGGACTCTGACGG	0.552			NA											16	2					0	0	0.004007	0	0
ATP2B3	492	broad.mit.edu	37	X	152814969	152814969	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:152814969C>A	uc004fht.1	+	9	1479	c.1353C>A	c.(1351-1353)GAC>GAA	p.D451E	ATP2B3_uc004fhs.1_Missense_Mutation_p.D451E	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	451	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGATGAAAGACAACAACCTGG	0.577			NA											41	16					5.44703e-19	7.88514e-19	0.009718	1	0
FLNA	2316	broad.mit.edu	37	X	153593005	153593005	+	Silent	SNP	C	C	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:153593005C>A	uc004fkk.2	-	13	2160	c.1911G>T	c.(1909-1911)CCG>CCT	p.P637P	FLNA_uc010nuu.1_Silent_p.P637P	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	637	Filamin 4.		P -> Q (in CVDX).		actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAGCCTCCTGCGGCCAGTAGC	0.617			NA											39	10					2.75727e-19	4.01246e-19	0.004878	1	0
PLXNA3	55558	broad.mit.edu	37	X	153698332	153698332	+	Missense_Mutation	SNP	G	G	T	rs142245785	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:153698332G>T	uc004flm.2	+	29	4981	c.4808G>T	c.(4807-4809)CGC>CTC	p.R1603L		NM_017514	NP_059984	P51805	PLXA3_HUMAN	plexin A3 precursor	1603	Cytoplasmic (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGCTTGCTCCGCACGGCCAGC	0.622			NA											28	3					7.76418e-22	1.18236e-21	0.005443	1	0
G6PD	2539	broad.mit.edu	37	X	153762266	153762266	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:153762266C>G	uc004fly.1	-	7	867	c.754G>C	c.(754-756)GAA>CAA	p.E252Q	G6PD_uc004flx.1_Missense_Mutation_p.E282Q	NM_001042351	NP_001035810	P11413	G6PD_HUMAN	glucose-6-phosphate dehydrogenase isoform b	252					cellular response to oxidative stress|cholesterol biosynthetic process|cytokine production|erythrocyte maturation|glucose 6-phosphate metabolic process|glutathione metabolic process|negative regulation of protein glutathionylation|pentose-phosphate shunt, oxidative branch|ribose phosphate biosynthetic process	centrosome|cytosol|internal side of plasma membrane|intracellular membrane-bounded organelle	glucose binding|glucose-6-phosphate dehydrogenase activity|NADP binding|protein homodimerization activity			ovary(4)	4	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					ATCCCAAATTCATCGAAATAG	0.592			NA											33	11					0	0	0.003271	0	0
F8	2157	broad.mit.edu	37	X	154157366	154157366	+	Nonsense_Mutation	SNP	T	T	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:154157366T>A	uc004fmt.2	-	14	4870	c.4699A>T	c.(4699-4701)AGA>TGA	p.R1567*		NM_000132	NP_000123	P00451	FA8_HUMAN	coagulation factor VIII isoform a precursor	1567	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			ovary(5)|large_intestine(2)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	11	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GTTGCTACTCTCAGAAAGGGA	0.478			NA											79	27					0	0	0.00361	0	0
ATAD3B	83858	broad.mit.edu	37	1	1430994	1430995	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:1430994_1430995delGA	uc001afv.2	+	16	1845_1846	c.1744_1745delGA	c.(1744-1746)GAGfs	p.E582fs	ATAD3B_uc001afx.2_Frame_Shift_Del_p.E536fs|ATAD3B_uc001afy.2_Frame_Shift_Del_p.E135fs	NM_031921	NP_114127	Q5T9A4	ATD3B_HUMAN	AAA-ATPase  TOB3	582							ATP binding|nucleoside-triphosphatase activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCGCGGGGTCGAGCACCCCCTA	0.649			NA											29	79	---	---	---	---	NA	NA	NA	NA	NA
KIAA1751	85452	broad.mit.edu	37	1	1900161	1900161	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:1900161delC	uc001aim.1	-	11	1314	c.1158delG	c.(1156-1158)AGGfs	p.R386fs	KIAA1751_uc009vkz.1_Frame_Shift_Del_p.R386fs	NM_001080484	NP_001073953	Q9C0B2	K1751_HUMAN	hypothetical protein LOC85452	386										pancreas(1)	1	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;8.79e-39)|OV - Ovarian serous cystadenocarcinoma(86;9.61e-25)|GBM - Glioblastoma multiforme(42;1.2e-07)|Colorectal(212;4.84e-05)|COAD - Colon adenocarcinoma(227;0.000214)|Kidney(185;0.00254)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.037)|Lung(427;0.205)		TCAGCCGGTGCCTGGCACTGG	0.527			NA											284	95	---	---	---	---	NA	NA	NA	NA	NA
USP24	23358	broad.mit.edu	37	1	55567332	55567332	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:55567332delC	uc001cyg.3	-	40	4590	c.4590delG	c.(4588-4590)GGGfs	p.G1530fs		NM_015306	NP_056121	Q9UPU5	UBP24_HUMAN	ubiquitin specific protease 24	1690					ubiquitin-dependent protein catabolic process		binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(6)|kidney(6)|breast(1)	13						CATTTCTCAGCCCCACAAACC	0.463			NA											8	32	---	---	---	---	NA	NA	NA	NA	NA
LRRC7	57554	broad.mit.edu	37	1	70493969	70493970	+	Frame_Shift_Ins	INS	-	-	AA			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:70493969_70493970insAA	uc001dep.2	+	16	1826_1827	c.1796_1797insAA	c.(1795-1797)TCAfs	p.S599fs	LRRC7_uc009wbg.2_Intron	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	599						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						GTTGAGAATTCAAATCCAACTG	0.406			NA											31	23	---	---	---	---	NA	NA	NA	NA	NA
CLCA2	9635	broad.mit.edu	37	1	86904751	86904751	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:86904751delG	uc001dlr.3	+	7	1327	c.1165delG	c.(1165-1167)GACfs	p.D389fs		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	389	VWFA.|Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AGCTAAAACAGACATCAGCAT	0.428	Melanoma(157;1000 1898 5363 5664 48018)|Ovarian(88;135 1366 2838 28875 34642)		NA											11	41	---	---	---	---	NA	NA	NA	NA	NA
C1orf59	113802	broad.mit.edu	37	1	109197453	109197453	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:109197453delG	uc001dvt.3	-	5	521	c.283delC	c.(283-285)CTGfs	p.L95fs	C1orf59_uc001dvu.3_Frame_Shift_Del_p.L95fs|C1orf59_uc009wer.2_Frame_Shift_Del_p.L95fs	NM_001102592	NP_001096062	Q5T8I9	HENMT_HUMAN	hypothetical protein LOC113802	95					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity				0		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0152)|Lung(183;0.0895)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.163)		AAATCCCCCAGGAAAGGAGCT	0.398			NA											11	14	---	---	---	---	NA	NA	NA	NA	NA
TTF2	8458	broad.mit.edu	37	1	117626641	117626642	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:117626641_117626642delCT	uc001egy.2	+	11	1925_1926	c.1905_1906delCT	c.(1903-1908)GACTCTfs	p.D635fs		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	635_636	Helicase ATP-binding.				mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		CTTCTCAAGACTCTTGTGACTT	0.327			NA											23	34	---	---	---	---	NA	NA	NA	NA	NA
C1orf61	10485	broad.mit.edu	37	1	156384451	156384451	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:156384451delG	uc001fou.1	-	4	283	c.166delC	c.(166-168)CGGfs	p.R56fs	C1orf61_uc001fov.1_RNA|C1orf61_uc001fow.1_Intron|C1orf61_uc001fox.1_RNA|C1orf61_uc001foy.1_RNA	NM_006365	NP_006356	Q13536	CROC4_HUMAN	transcriptional activator of the c-fos promoter	56						nucleus				skin(1)	1	Hepatocellular(266;0.158)					CTCACCGCCCGGGAGCTGTCC	0.562			NA									OREG0006902	type=TRANSCRIPTION FACTOR BINDING SITE|Gene=C1orf61|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	21	23	---	---	---	---	NA	NA	NA	NA	NA
DARC	2532	broad.mit.edu	37	1	159175850	159175850	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:159175850delG	uc001fto.2	+	2	861	c.621delG	c.(619-621)CAGfs	p.Q207fs	DARC_uc001ftp.3_Frame_Shift_Del_p.Q209fs	NM_002036	NP_002027	Q16570	DUFFY_HUMAN	Duffy blood group antigen isoform b	207	Extracellular (Potential).				defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			ovary(1)|lung(1)	2	all_hematologic(112;0.0429)					AGGCTTTGCAGGCCACACACA	0.577			NA											17	22	---	---	---	---	NA	NA	NA	NA	NA
HMCN1	83872	broad.mit.edu	37	1	186062769	186062769	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr1:186062769delT	uc001grq.1	+	66	10393	c.10164delT	c.(10162-10164)CATfs	p.H3388fs		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3388	Ig-like C2-type 32.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TCTCCTCCCATATCCGGTTAC	0.433			NA											36	122	---	---	---	---	NA	NA	NA	NA	NA
APBB1IP	54518	broad.mit.edu	37	10	26825135	26825135	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:26825135delG	uc001iss.2	+	10	1354	c.1033delG	c.(1033-1035)GGAfs	p.G345fs	APBB1IP_uc009xks.1_Frame_Shift_Del_p.G345fs	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	345	PH.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						TGTACCCAAAGGAAAGACTAA	0.328			NA											70	78	---	---	---	---	NA	NA	NA	NA	NA
RBP3	5949	broad.mit.edu	37	10	48388734	48388734	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:48388734delG	uc001jez.2	-	1	2258	c.2144delC	c.(2143-2145)CCAfs	p.P715fs		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	715	4 X approximate tandem repeats.|3.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	AGGGGGTGGTGGGGGTGCTTC	0.627			NA											11	57	---	---	---	---	NA	NA	NA	NA	NA
SLK	9748	broad.mit.edu	37	10	105727509	105727511	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:105727509_105727511delCTT	uc001kxo.1	+	1	40_42	c.6_8delCTT	c.(4-9)TCCTTC>TCC	p.F4del	SLK_uc001kxp.1_In_Frame_Del_p.F4del	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	4					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAAAAATGTCCTTCTTCAATTTC	0.394	NSCLC(111;540 1651 1927 4474 17706)		NA											65	15	---	---	---	---	NA	NA	NA	NA	NA
HABP2	3026	broad.mit.edu	37	10	115312947	115312948	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr10:115312947_115312948delGG	uc001lai.3	+	1	170_171	c.67_68delGG	c.(67-69)GGGfs	p.G23fs	HABP2_uc010qrz.1_RNA|HABP2_uc010qry.1_5'UTR	NM_004132	NP_004123	Q14520	HABP2_HUMAN	hyaluronan binding protein 2 preproprotein	23					cell adhesion|proteolysis	extracellular space	glycosaminoglycan binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.0233)|Breast(234;0.0672)		Epithelial(162;0.00319)|all cancers(201;0.0112)		GACAGCCTGTGGGGTAAGTGTT	0.441			NA											34	18	---	---	---	---	NA	NA	NA	NA	NA
OR8K1	390157	broad.mit.edu	37	11	56113743	56113743	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:56113743delC	uc010rjg.1	+	1	229	c.229delC	c.(229-231)CTTfs	p.L77fs		NM_001002907	NP_001002907	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AATCACTGATCTTGGTTACTC	0.418			NA								HNSCC(65;0.19)			34	92	---	---	---	---	NA	NA	NA	NA	NA
LTBP3	4054	broad.mit.edu	37	11	65308712	65308713	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:65308712_65308713delTG	uc001oej.2	-	20	3046_3047	c.2777_2778delCA	c.(2776-2778)ACAfs	p.T926fs	LTBP3_uc001oef.2_5'UTR|LTBP3_uc001oeg.2_5'UTR|LTBP3_uc001oeh.2_Frame_Shift_Del_p.T356fs|LTBP3_uc010roi.1_Frame_Shift_Del_p.T809fs|LTBP3_uc001oei.2_Frame_Shift_Del_p.T926fs|LTBP3_uc010roj.1_Frame_Shift_Del_p.T627fs|LTBP3_uc010rok.1_Frame_Shift_Del_p.T837fs	NM_001130144	NP_001123616	Q9NS15	LTBP3_HUMAN	latent transforming growth factor beta binding	926	TB 3.					extracellular region	calcium ion binding|growth factor binding			central_nervous_system(2)|lung(1)	3						CGCAGAACACTGTGTCATCGAA	0.634			NA									OREG0021080	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	86	---	---	---	---	NA	NA	NA	NA	NA
C11orf80	79703	broad.mit.edu	37	11	66583618	66583619	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TC	TC	-	-	TC	TC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:66583618_66583619delTC	uc001ojf.2	+	11	1291_1292	c.1284_1285delTC	c.(1282-1287)TTTCTCfs	p.F428fs	C11orf80_uc001ojg.2_Frame_Shift_Del_p.F195fs|C11orf80_uc001ojh.2_Frame_Shift_Del_p.F196fs|C11orf80_uc001oji.2_Frame_Shift_Del_p.F196fs|C11orf80_uc010rpl.1_Frame_Shift_Del_p.F63fs|C11orf80_uc001ojj.2_Frame_Shift_Del_p.F63fs	NM_024650	NP_078926	Q8N6T0	CK080_HUMAN	hypothetical protein LOC79703	273_274											0						TGCTGCTTTTTCTCTTTGTGGA	0.465			NA											13	12	---	---	---	---	NA	NA	NA	NA	NA
NUMA1	4926	broad.mit.edu	37	11	71717101	71717107	+	Frame_Shift_Del	DEL	ACCCCGG	ACCCCGG	-	rs61745941	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	ACCCCGG	ACCCCGG	-	-	ACCCCGG	ACCCCGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:71717101_71717107delACCCCGG	uc001orl.1	-	22	5838_5844	c.5666_5672delCCGGGGT	c.(5665-5673)GCCGGGGTGfs	p.A1889fs	NUMA1_uc001orj.2_Frame_Shift_Del_p.A71fs|NUMA1_uc009ysw.1_Frame_Shift_Del_p.A1456fs|NUMA1_uc001ork.1_Frame_Shift_Del_p.A753fs|NUMA1_uc001orm.1_Frame_Shift_Del_p.A1875fs	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1889_1891					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CCCACTGGACACCCCGGCCTGGGAACG	0.589			NA	T	RARA	APL								45	68	---	---	---	---	NA	NA	NA	NA	NA
CREBZF	58487	broad.mit.edu	37	11	85375242	85375244	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:85375242_85375244delCTT	uc001pas.2	-	1	939_941	c.676_678delAAG	c.(676-678)AAGdel	p.K226del	CREBZF_uc010rtc.1_RNA|CREBZF_uc010rtd.1_RNA	NM_001039618	NP_001034707	Q9NS37	ZHANG_HUMAN	HCF-binding transcription factor Zhangfei	226	Basic motif.				negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|response to virus	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)				TCACGTACTCCTTCTTCTTCAGT	0.384	NSCLC(172;674 2044 9050 18334 41735)		NA									OREG0021274	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	163	---	---	---	---	NA	NA	NA	NA	NA
NCAM1	4684	broad.mit.edu	37	11	113102898	113102899	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr11:113102898_113102899insA	uc009yyq.1	+	12	1665_1666	c.971_972insA	c.(970-972)CCAfs	p.P324fs		NM_001076682	NP_001070150	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1 isoform 3	416	Ig-like C2-type 5.|Extracellular (Potential).				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCAGATGCCCCAAAGCTACAGG	0.525			NA											18	12	---	---	---	---	NA	NA	NA	NA	NA
MIA2	117153	broad.mit.edu	37	14	39716860	39716860	+	Frame_Shift_Del	DEL	A	A	-	rs141053276		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr14:39716860delA	uc001wux.2	+	4	1276	c.1082delA	c.(1081-1083)GAAfs	p.E361fs	MIA2_uc010amy.1_Frame_Shift_Del_p.E292fs	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	361						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		ATATTAACAGAAAAAAAAGAC	0.348			NA											52	32	---	---	---	---	NA	NA	NA	NA	NA
SPPL2A	84888	broad.mit.edu	37	15	51040893	51040894	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:51040893_51040894delTG	uc001zyv.2	-	3	531_532	c.351_352delCA	c.(349-354)AACAGTfs	p.N117fs		NM_032802	NP_116191	Q8TCT8	PSL2_HUMAN	signal peptide peptidase-like 2A	117_118	Cytoplasmic (Potential).|PA.					integral to membrane	aspartic-type endopeptidase activity				0				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		ACTAGGACACTGTTATTGACAA	0.371	Melanoma(50;790 1209 4069 22965 33125)		NA											69	22	---	---	---	---	NA	NA	NA	NA	NA
USP3	9960	broad.mit.edu	37	15	63862705	63862705	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:63862705delG	uc002amf.2	+	9	964	c.835delG	c.(835-837)GGTfs	p.G279fs	USP3_uc010uii.1_RNA|USP3_uc002amg.2_Frame_Shift_Del_p.G194fs|USP3_uc002amh.2_Frame_Shift_Del_p.G257fs|USP3_uc010uij.1_Frame_Shift_Del_p.G235fs|USP3_uc010uik.1_Frame_Shift_Del_p.G30fs|USP3_uc010bgs.2_Frame_Shift_Del_p.G262fs|USP3_uc002ami.2_Frame_Shift_Del_p.G110fs	NM_006537	NP_006528	Q9Y6I4	UBP3_HUMAN	ubiquitin thiolesterase 3	279					DNA repair|histone deubiquitination|mitotic cell cycle|regulation of protein stability|ubiquitin-dependent protein catabolic process	nuclear chromatin	histone binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			lung(1)	1				GBM - Glioblastoma multiforme(80;0.0187)		ACTTCAGGGCGGTTTCAACGG	0.443			NA											37	46	---	---	---	---	NA	NA	NA	NA	NA
IDH2	3418	broad.mit.edu	37	15	90631962	90631964	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TCT	TCT	-	-	TCT	TCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr15:90631962_90631964delTCT	uc002box.2	-	4	475_477	c.389_391delAGA	c.(388-393)AAGATG>ATG	p.K130del	IDH2_uc010uqb.1_In_Frame_Del_p.K78del|IDH2_uc010uqc.1_Translation_Start_Site|IDH2_uc010bnu.2_Intron	NM_002168	NP_002159	P48735	IDHP_HUMAN	isocitrate dehydrogenase 2 (NADP+),	130					2-oxoglutarate metabolic process|glyoxylate cycle|isocitrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding			haematopoietic_and_lymphoid_tissue(621)|central_nervous_system(80)|bone(7)|skin(3)	711	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.106)			CTTTTCCACATCTTCTTCAGCTT	0.522			NA	M		GBM								15	56	---	---	---	---	NA	NA	NA	NA	NA
CLDN6	9074	broad.mit.edu	37	16	3065398	3065399	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GA	GA	-	-	GA	GA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:3065398_3065399delGA	uc002csu.3	-	2	684_685	c.624_625delTC	c.(622-627)TCTCGGfs	p.S208fs		NM_021195	NP_067018	P56747	CLD6_HUMAN	claudin 6	208_209	Cytoplasmic (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity				0						GAGGGCCCCCGAGAGATGGCAG	0.644			NA											24	81	---	---	---	---	NA	NA	NA	NA	NA
CCDC64B	146439	broad.mit.edu	37	16	3080710	3080711	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:3080710_3080711delCT	uc002ctf.3	-	3	646_647	c.601_602delAG	c.(601-603)AGTfs	p.S201fs	CCDC64B_uc002cte.3_5'UTR|CCDC64B_uc010bta.1_3'UTR	NM_001103175	NP_001096645	A1A5D9	BICR2_HUMAN	coiled-coil domain containing 64B	201	Potential.										0						CCCCTGCAGACTCTCCAGCCGC	0.644			NA											5	8	---	---	---	---	NA	NA	NA	NA	NA
COQ7	10229	broad.mit.edu	37	16	19079004	19079004	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:19079004delG	uc002dfr.2	+	1	78	c.18delG	c.(16-18)GCGfs	p.A6fs	COQ7_uc002dfs.2_5'Flank	NM_016138	NP_057222	Q99807	COQ7_HUMAN	COQ7 protein	6	Poly-Ala.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			skin(1)	1						gcgccggggcggcggcggctc	0.398			NA											8	12	---	---	---	---	NA	NA	NA	NA	NA
CDH11	1009	broad.mit.edu	37	16	65015995	65015995	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:65015995delC	uc002eoi.2	-	8	1643	c.1209delG	c.(1207-1209)GGGfs	p.G403fs	CDH11_uc010cdn.2_Intron|CDH11_uc002eoj.2_Frame_Shift_Del_p.G403fs|CDH11_uc010vin.1_Frame_Shift_Del_p.G277fs|CDH11_uc002eok.1_RNA	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	403	Cadherin 4.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CATGCACTCTCCCAACCACGG	0.488			NA	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			27	27	---	---	---	---	NA	NA	NA	NA	NA
FTSJD1	55783	broad.mit.edu	37	16	71319263	71319263	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr16:71319263delA	uc010cga.2	-	3	967	c.561delT	c.(559-561)ATTfs	p.I187fs	FTSJD1_uc002ezy.3_Frame_Shift_Del_p.I187fs|FTSJD1_uc002ezz.3_Frame_Shift_Del_p.I187fs	NM_001099642	NP_001093112	Q8IYT2	FTSJ1_HUMAN	FtsJ methyltransferase domain containing 1	187						integral to membrane	methyltransferase activity|nucleic acid binding			skin(1)	1						GGTCATCCATAATCATCATGA	0.428			NA											29	8	---	---	---	---	NA	NA	NA	NA	NA
KCNJ2	3759	broad.mit.edu	37	17	68171564	68171564	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:68171564delC	uc010dfg.2	+	2	785	c.384delC	c.(382-384)AGCfs	p.S128fs	KCNJ2_uc002jir.2_Frame_Shift_Del_p.S128fs	NM_000891	NP_000882	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel J2	128	Extracellular (By similarity).				synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding				0	Breast(10;1.64e-08)					AGGTCAACAGCTTCACGGCTG	0.502			NA											60	76	---	---	---	---	NA	NA	NA	NA	NA
SDK2	54549	broad.mit.edu	37	17	71394500	71394510	+	Frame_Shift_Del	DEL	GCGGGCATCGG	GCGGGCATCGG	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GCGGGCATCGG	GCGGGCATCGG	-	-	GCGGGCATCGG	GCGGGCATCGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr17:71394500_71394510delGCGGGCATCGG	uc010dfm.2	-	23	3152_3162	c.3152_3162delCCGATGCCCGC	c.(3151-3162)CCCGATGCCCGCfs	p.P1051fs	SDK2_uc002jjt.3_Frame_Shift_Del_p.P210fs|SDK2_uc010dfn.2_Frame_Shift_Del_p.P730fs	NM_001144952	NP_001138424	Q58EX2	SDK2_HUMAN	sidekick 2	1051_1054	Fibronectin type-III 5.|Extracellular (Potential).				cell adhesion	integral to membrane				ovary(2)	2						CCTCCATGGAGCGGGCATCGGGCTCATTGGA	0.64			NA											9	71	---	---	---	---	NA	NA	NA	NA	NA
AQP4	361	broad.mit.edu	37	18	24441125	24441125	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:24441125delT	uc002kwa.2	-	3	645	c.582delA	c.(580-582)GGAfs	p.G194fs	AQP4_uc002kvz.2_Frame_Shift_Del_p.G172fs	NM_001650	NP_001641	P55087	AQP4_HUMAN	aquaporin 4 isoform a	194	Helical; (Potential).				cellular response to interferon-gamma|excretion|nervous system development	cytoplasm|external side of plasma membrane|integral to plasma membrane	water channel activity				0	all_cancers(21;0.0172)|Lung NSC(5;0.00299)|all_lung(6;0.00747)|Ovarian(20;0.124)					CAACAGAAAATCCAATTGCTA	0.383			NA											68	11	---	---	---	---	NA	NA	NA	NA	NA
DSEL	92126	broad.mit.edu	37	18	65179594	65179594	+	Frame_Shift_Del	DEL	C	C	-	rs149331251		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr18:65179594delC	uc002lke.1	-	2	3506	c.2282delG	c.(2281-2283)GGCfs	p.G761fs		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	751						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				TGCTTGAGTGCCCAAACCAAA	0.383			NA											25	3	---	---	---	---	NA	NA	NA	NA	NA
ZNF562	54811	broad.mit.edu	37	19	9764212	9764213	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:9764212_9764213delAG	uc010xks.1	-	6	856_857	c.693_694delCT	c.(691-696)CTCTGTfs	p.L231fs	ZNF562_uc002mly.2_Frame_Shift_Del_p.L231fs|ZNF562_uc002mlx.2_Frame_Shift_Del_p.L159fs|ZNF562_uc010xkt.1_Frame_Shift_Del_p.L194fs|ZNF562_uc010xku.1_Frame_Shift_Del_p.L162fs|ZNF562_uc010xkv.1_Frame_Shift_Del_p.L230fs|ZNF562_uc010xkw.1_Frame_Shift_Del_p.L115fs	NM_001130032	NP_001123504	Q6V9R5	ZN562_HUMAN	zinc finger protein 562 isoform a	231_232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGAAATTCACAGAGTTTCTCTC	0.396			NA											40	12	---	---	---	---	NA	NA	NA	NA	NA
PBX4	80714	broad.mit.edu	37	19	19672896	19672896	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:19672896delG	uc002nmy.2	-	8	1064	c.1063delC	c.(1063-1065)CAAfs	p.Q355fs	PBX4_uc010xqz.1_RNA|PBX4_uc010xra.1_Frame_Shift_Del_p.Q190fs	NM_025245	NP_079521	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	355							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						GTTGCAGGTTGGGGGGTGGCC	0.597			NA											8	7	---	---	---	---	NA	NA	NA	NA	NA
PSG2	5670	broad.mit.edu	37	19	43576090	43576090	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr19:43576090delG	uc002ovr.2	-	4	819	c.726delC	c.(724-726)CCCfs	p.P242fs	PSG6_uc002ovi.2_Intron|PSG6_uc010xwk.1_Intron|PSG2_uc002ovq.3_Frame_Shift_Del_p.P242fs|PSG2_uc010eiq.1_Frame_Shift_Del_p.P242fs|PSG2_uc002ovs.3_Frame_Shift_Del_p.P242fs|PSG2_uc002ovt.3_Frame_Shift_Del_p.P242fs	NM_031246	NP_112536	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	242	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region					0		Prostate(69;0.00682)				GGTGAATTCTGGGGAGGTCTG	0.493			NA											125	37	---	---	---	---	NA	NA	NA	NA	NA
ITPRIPL1	150771	broad.mit.edu	37	2	96993095	96993095	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:96993095delC	uc002svx.2	+	3	1061	c.726delC	c.(724-726)GTCfs	p.V242fs	ITPRIPL1_uc010yuk.1_Frame_Shift_Del_p.V234fs|ITPRIPL1_uc002svy.2_Frame_Shift_Del_p.V250fs|ITPRIPL1_uc010yul.1_Frame_Shift_Del_p.V234fs	NM_001008949	NP_001008949	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-triphosphate receptor interacting	242	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(2)|ovary(1)	3						TGCCCATTGTCCCCCCACAGG	0.587			NA											15	29	---	---	---	---	NA	NA	NA	NA	NA
CCDC93	54520	broad.mit.edu	37	2	118704407	118704408	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:118704407_118704408delCT	uc002tlj.2	-	16	1401_1402	c.1275_1276delAG	c.(1273-1278)AGAGCAfs	p.R425fs	CCDC93_uc010fld.1_Frame_Shift_Del_p.R425fs	NM_019044	NP_061917	Q567U6	CCD93_HUMAN	coiled-coil domain containing 93	425_426	Potential.									large_intestine(1)|ovary(1)	2						CCACGTGGTGCTCTCTCAGCTT	0.406			NA											15	94	---	---	---	---	NA	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	141298599	141298599	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:141298599delT	uc002tvj.1	-	45	8428	c.7456delA	c.(7456-7458)AGAfs	p.R2486fs		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2486	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CAATTCACTCTCCCATTGGGA	0.403	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			33	39	---	---	---	---	NA	NA	NA	NA	NA
MYL1	4632	broad.mit.edu	37	2	211163245	211163271	+	In_Frame_Del	DEL	GAATCACCTGTTCTGTCAAACAGGAGA	GAATCACCTGTTCTGTCAAACAGGAGA	-	rs11554011		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	GAATCACCTGTTCTGTCAAACAGGAGA	GAATCACCTGTTCTGTCAAACAGGAGA	-	-	GAATCACCTGTTCTGTCAAACAGGAGA	GAATCACCTGTTCTGTCAAACAGGAGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:211163245_211163271delGAATCACCTGTTCTGTCAAACAGGAGA	uc002vec.2	-	3	306_332	c.177_203delTCTCCTGTTTGACAGAACAGGTGATTC	c.(175-204)TTTCTCCTGTTTGACAGAACAGGTGATTCC>TTC	p.LLFDRTGDS60del	MYL1_uc002veb.2_In_Frame_Del_p.LLFDRTGDS16del	NM_079420	NP_524144	P05976	MYL1_HUMAN	fast skeletal myosin alkali light chain 1	60_68	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			ovary(1)	1				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GGTGATCTTGGAATCACCTGTTCTGTCAAACAGGAGAAATGCCTCCT	0.427			NA											8	31	---	---	---	---	NA	NA	NA	NA	NA
SLC11A1	6556	broad.mit.edu	37	2	219251925	219251927	+	In_Frame_Del	DEL	CTT	CTT	-	rs145226482	by1000genomes	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr2:219251925_219251927delCTT	uc002vhv.2	+	6	883_885	c.543_545delCTT	c.(541-546)ACCTTC>ACC	p.F184del	SLC11A1_uc010zkb.1_3'UTR|SLC11A1_uc010fvp.1_In_Frame_Del_p.F184del|SLC11A1_uc010fvq.1_In_Frame_Del_p.F117del|SLC11A1_uc010zkc.1_In_Frame_Del_p.F117del|SLC11A1_uc002vhu.1_5'UTR|SLC11A1_uc002vhw.2_In_Frame_Del_p.F66del|SLC11A1_uc010fvr.2_5'UTR	NM_000578	NP_000569	P49279	NRAM1_HUMAN	natural resistance-associated macrophage protein	184	Helical; (Potential).				activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			ovary(3)|central_nervous_system(1)	4		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCGTGGACACCTTCTTCTTCCTC	0.552			NA											9	98	---	---	---	---	NA	NA	NA	NA	NA
ADRM1	11047	broad.mit.edu	37	20	60881371	60881372	+	In_Frame_Ins	INS	-	-	AGGCGG			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr20:60881371_60881372insAGGCGG	uc002ycn.2	+	4	529_530	c.449_450insAGGCGG	c.(448-450)CTA>CTAGGCGGA	p.152_153insGG	ADRM1_uc011aai.1_In_Frame_Ins_p.152_153insGG|ADRM1_uc002yco.2_In_Frame_Ins_p.152_153insGG|ADRM1_uc002ycp.1_RNA	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	152_153	Gly-rich.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			CTCTCTGCGCTAGGCGGTAACT	0.599			NA											15	193	---	---	---	---	NA	NA	NA	NA	NA
BCL2L13	23786	broad.mit.edu	37	22	18210074	18210076	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	AGA	AGA	-	-	AGA	AGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:18210074_18210076delAGA	uc002zmw.2	+	7	1450_1452	c.1232_1234delAGA	c.(1231-1236)GAGAAG>GAG	p.K412del	BCL2L13_uc002zmx.2_In_Frame_Del_p.K250del|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_In_Frame_Del_p.K250del|BCL2L13_uc011agk.1_In_Frame_Del_p.K288del|BCL2L13_uc010gqz.2_In_Frame_Del_p.K132del|BCL2L13_uc002zmz.2_In_Frame_Del_p.K250del|BCL2L13_uc002zna.2_In_Frame_Del_p.K132del	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	412	Glu-rich.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTGCTGAGTGAGAAGGAGATAAA	0.557			NA											28	99	---	---	---	---	NA	NA	NA	NA	NA
LRP5L	91355	broad.mit.edu	37	22	25753294	25753294	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:25753294delC	uc003abs.2	-	2	2831	c.366delG	c.(364-366)TGGfs	p.W122fs	LRP5L_uc011ajz.1_Frame_Shift_Del_p.W122fs|LRP5L_uc010guw.1_Frame_Shift_Del_p.W122fs	NM_182492	NP_872298	A4QPB2	LRP5L_HUMAN	low density lipoprotein receptor-related protein	122	LDL-receptor class B 3.										0						GGCCGTTGGGCCACCCGAGGG	0.597			NA											106	15	---	---	---	---	NA	NA	NA	NA	NA
SHANK3	85358	broad.mit.edu	37	22	51160242	51160242	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr22:51160242delC	uc003bne.1	+	22	4029	c.4029delC	c.(4027-4029)GGCfs	p.G1343fs	SHANK3_uc003bnf.1_Frame_Shift_Del_p.G790fs|SHANK3_uc010hbg.1_Frame_Shift_Del_p.G525fs	NM_001080420	NP_001073889	F2Z3L0	F2Z3L0_HUMAN	SH3 and multiple ankyrin repeat domains 3	1343										central_nervous_system(1)	1		all_cancers(38;3.75e-11)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		BRCA - Breast invasive adenocarcinoma(115;0.22)		CTGGCCCGGGCCCCTCGCCCA	0.701			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
TNIK	23043	broad.mit.edu	37	3	170858288	170858289	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr3:170858288_170858289delCG	uc003fhh.2	-	13	1576_1577	c.1231_1232delCG	c.(1231-1233)CGAfs	p.R411fs	TNIK_uc003fhi.2_Frame_Shift_Del_p.R411fs|TNIK_uc003fhj.2_Frame_Shift_Del_p.R411fs|TNIK_uc003fhk.2_Frame_Shift_Del_p.R411fs|TNIK_uc003fhl.2_Frame_Shift_Del_p.R411fs|TNIK_uc003fhm.2_Frame_Shift_Del_p.R411fs|TNIK_uc003fhn.2_Frame_Shift_Del_p.R411fs|TNIK_uc003fho.2_Frame_Shift_Del_p.R411fs	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1	411	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CTCCTTCTCTCGCCTTTGTTGC	0.624			NA											42	173	---	---	---	---	NA	NA	NA	NA	NA
PPARGC1A	10891	broad.mit.edu	37	4	23815781	23815781	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:23815781delT	uc003gqs.2	-	8	1445	c.1325delA	c.(1324-1326)AAGfs	p.K442fs	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	442					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				AGAGACCTGCTTGCTTGCCTC	0.488	Esophageal Squamous(29;694 744 13796 34866 44181)		NA											24	61	---	---	---	---	NA	NA	NA	NA	NA
KCTD8	386617	broad.mit.edu	37	4	44177021	44177021	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:44177021delG	uc003gwu.2	-	2	1492	c.1208delC	c.(1207-1209)CCAfs	p.P403fs		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	403						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						TTTGTCTGGTGGGGGTATCCA	0.483			NA								HNSCC(17;0.042)			65	220	---	---	---	---	NA	NA	NA	NA	NA
EPHA5	2044	broad.mit.edu	37	4	66467899	66467899	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:66467899delA	uc003hcy.2	-	3	563	c.370delT	c.(370-372)TCCfs	p.S124fs	EPHA5_uc003hcx.2_Frame_Shift_Del_p.S55fs|EPHA5_uc003hcz.2_Frame_Shift_Del_p.S124fs|EPHA5_uc011cah.1_Frame_Shift_Del_p.S124fs|EPHA5_uc011cai.1_Frame_Shift_Del_p.S124fs|EPHA5_uc003hda.2_Frame_Shift_Del_p.S124fs	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	124	Extracellular (Potential).				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						AAGATTCTGGAAGCACCTTCA	0.423			NA								TSP Lung(17;0.13)			34	46	---	---	---	---	NA	NA	NA	NA	NA
C4orf17	84103	broad.mit.edu	37	4	100443707	100443707	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:100443707delG	uc003huw.2	+	3	501	c.178delG	c.(178-180)GGAfs	p.G60fs	C4orf17_uc003hux.2_RNA	NM_032149	NP_115525	Q53FE4	CD017_HUMAN	hypothetical protein LOC84103	60											0				OV - Ovarian serous cystadenocarcinoma(123;2.08e-08)		GAATGCATTTGGAACATTGTG	0.428			NA											23	35	---	---	---	---	NA	NA	NA	NA	NA
FAT4	79633	broad.mit.edu	37	4	126372442	126372444	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CCT	CCT	-	-	CCT	CCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:126372442_126372444delCCT	uc003ifj.3	+	9	10271_10273	c.10271_10273delCCT	c.(10270-10275)ACCTTT>ATT	p.3424_3425TF>I	FAT4_uc011cgp.1_In_Frame_Del_p.1722_1723TF>I|FAT4_uc003ifi.1_In_Frame_Del_p.902_903TF>I	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3424_3425	Cadherin 33.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						ACTCATGTGACCTTTGTCAGTGC	0.453			NA											24	66	---	---	---	---	NA	NA	NA	NA	NA
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr4:147560457_147560458insGGC	uc003ikv.2	+	1	413_414	c.165_166insGGC	c.(163-168)insGGC	p.68_69insG		NM_004575	NP_004566	Q12837	PO4F2_HUMAN	Brn3b POU domain transcription factor	68_69					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			breast(1)	1	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.386			NA											5	7	---	---	---	---	NA	NA	NA	NA	NA
LIFR	3977	broad.mit.edu	37	5	38502756	38502758	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TGT	TGT	-	-	TGT	TGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:38502756_38502758delTGT	uc010ive.1	-	11	1913_1915	c.1581_1583delACA	c.(1579-1584)CAACAT>CAT	p.Q527del	LIFR_uc003jli.2_In_Frame_Del_p.Q527del	NM_001127671	NP_001121143	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor precursor	527	Extracellular (Potential).|Fibronectin type-III 3.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			ovary(3)|large_intestine(1)	4	all_lung(31;0.00021)					TGTTGTTAAATGTTGTTTTTTAT	0.31	Melanoma(13;4 730 6426 9861 34751)		NA	T	PLAG1	salivary adenoma								33	75	---	---	---	---	NA	NA	NA	NA	NA
PCDHB8	56128	broad.mit.edu	37	5	140558334	140558334	+	Frame_Shift_Del	DEL	C	C	-	rs138380475		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr5:140558334delC	uc011dai.1	+	1	905	c.719delC	c.(718-720)GCCfs	p.A240fs	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	240	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AATGATAATGCCCCTGAATTT	0.507			NA											83	237	---	---	---	---	NA	NA	NA	NA	NA
TAAR9	134860	broad.mit.edu	37	6	132859668	132859668	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:132859668delG	uc011eci.1	+	2	242	c.240delG	c.(238-240)TTGfs	p.L80fs		NM_175057	NP_778227	Q96RI9	TAAR9_HUMAN	trace amine associated receptor 9	80	Helical; Name=2; (Potential).					plasma membrane	G-protein coupled receptor activity				0	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.0042)|GBM - Glioblastoma multiforme(226;0.00816)		CTGACTTCTTGGTGGGAGTCA	0.463	Colon(10;433 445 15992 45047 47213)		NA											24	57	---	---	---	---	NA	NA	NA	NA	NA
LATS1	9113	broad.mit.edu	37	6	150005349	150005349	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr6:150005349delT	uc003qmu.1	-	4	1424	c.876delA	c.(874-876)CCAfs	p.P292fs	LATS1_uc010kif.1_Frame_Shift_Del_p.P187fs|LATS1_uc003qmv.1_Frame_Shift_Del_p.P292fs|LATS1_uc003qmw.2_Frame_Shift_Del_p.P292fs|LATS1_uc010kig.1_Frame_Shift_Del_p.P187fs	NM_004690	NP_004681	O95835	LATS1_HUMAN	LATS homolog 1	292					cell division|cytoplasmic sequestering of protein|G2/M transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|positive regulation of peptidyl-serine phosphorylation|regulation of actin filament polymerization|sister chromatid segregation	microtubule organizing center|spindle pole	ATP binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity			lung(5)|central_nervous_system(1)	6		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;6.93e-13)|GBM - Glioblastoma multiforme(68;0.116)		ATGCCCCAGGTGGGACAGGAG	0.507			NA											73	17	---	---	---	---	NA	NA	NA	NA	NA
DGKB	1607	broad.mit.edu	37	7	14880840	14880840	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:14880840delG	uc003ssz.2	-	1	236	c.49delC	c.(49-51)CAAfs	p.Q17fs	DGKB_uc011jxt.1_Frame_Shift_Del_p.Q17fs|DGKB_uc003sta.2_Frame_Shift_Del_p.Q17fs|DGKB_uc011jxu.1_Frame_Shift_Del_p.Q17fs|DGKB_uc011jxv.1_Frame_Shift_Del_p.Q17fs	NM_004080	NP_004071	Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta isoform 1	17					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			lung(5)|ovary(4)|breast(2)|skin(1)	12					Phosphatidylserine(DB00144)	TTCTGAAGTTGGGAAAATTCC	0.368			NA											16	16	---	---	---	---	NA	NA	NA	NA	NA
ADCYAP1R1	117	broad.mit.edu	37	7	31117644	31117644	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:31117644delC	uc003tca.1	+	4	419	c.196delC	c.(196-198)CCCfs	p.P66fs	ADCYAP1R1_uc003tcb.1_Frame_Shift_Del_p.P66fs|ADCYAP1R1_uc003tcc.1_Frame_Shift_Del_p.P66fs|ADCYAP1R1_uc003tcd.1_Frame_Shift_Del_p.P66fs|ADCYAP1R1_uc003tce.1_Frame_Shift_Del_p.P66fs	NM_001118	NP_001109	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1	66	Extracellular (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			ovary(1)	1						GTGTTGGAAGCCCGCCCATGT	0.512	Ovarian(44;225 1186 2158 11092)		NA											18	91	---	---	---	---	NA	NA	NA	NA	NA
CCDC129	223075	broad.mit.edu	37	7	31692358	31692360	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	CTT	CTT	-	-	CTT	CTT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:31692358_31692360delCTT	uc003tcj.1	+	14	4043_4045	c.3050_3052delCTT	c.(3049-3054)CCTTCA>CCA	p.S1020del	CCDC129_uc011kad.1_In_Frame_Del_p.S1030del|CCDC129_uc003tci.1_In_Frame_Del_p.S871del|CCDC129_uc011kae.1_Intron|CCDC129_uc003tck.1_In_Frame_Del_p.S928del	NM_194300	NP_919276	Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	1020											0						AGGATGTCTCCTTCATCATCAGC	0.522			NA											22	96	---	---	---	---	NA	NA	NA	NA	NA
TNS3	64759	broad.mit.edu	37	7	47407966	47407966	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:47407966delC	uc003tnv.2	-	17	2644	c.2277delG	c.(2275-2277)CGGfs	p.R759fs	TNS3_uc003tnw.2_Frame_Shift_Del_p.R759fs	NM_022748	NP_073585	Q68CZ2	TENS3_HUMAN	tensin 3	759						focal adhesion	protein binding			ovary(4)	4						GCTCACCTTGCCGCCCGGTGG	0.632			NA											55	301	---	---	---	---	NA	NA	NA	NA	NA
IQUB	154865	broad.mit.edu	37	7	123109440	123109440	+	Splice_Site	DEL	T	T	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:123109440delT	uc003vkn.2	-	9	1988	c.1411_splice	c.e9-1	p.C471_splice	IQUB_uc003vko.2_Splice_Site_p.C471_splice|IQUB_uc010lkt.2_Splice_Site|IQUB_uc003vkp.1_Splice_Site_p.C471_splice	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing											ovary(3)|large_intestine(1)	4						AGCTGAACACttaaaaataat	0.313			NA											21	6	---	---	---	---	NA	NA	NA	NA	NA
REPIN1	29803	broad.mit.edu	37	7	150069438	150069439	+	Frame_Shift_Ins	INS	-	-	C			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr7:150069438_150069439insC	uc010lpq.1	+	4	1597_1598	c.1108_1109insC	c.(1108-1110)GCCfs	p.A370fs	REPIN1_uc003whd.2_Frame_Shift_Ins_p.A359fs|REPIN1_uc010lpr.1_Frame_Shift_Ins_p.A427fs|REPIN1_uc003whc.2_Frame_Shift_Ins_p.A370fs|REPIN1_uc003whe.2_Frame_Shift_Ins_p.A370fs	NM_013400	NP_037532	Q9BWE0	REPI1_HUMAN	replication initiator 1 isoform 1	370	Pro-rich.				DNA replication	nuclear origin of replication recognition complex	DNA binding|zinc ion binding			pancreas(1)	1	Ovarian(565;0.183)|Melanoma(164;0.226)		OV - Ovarian serous cystadenocarcinoma(82;0.011)			CCCGATCGAAGCCCCCCCCTCC	0.752			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
NBN	4683	broad.mit.edu	37	8	90965709	90965709	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:90965709delG	uc003yej.1	-	11	1718	c.1608delC	c.(1606-1608)GCCfs	p.A536fs	NBN_uc003yei.1_Frame_Shift_Del_p.A454fs|NBN_uc011lgb.1_Frame_Shift_Del_p.A536fs	NM_002485	NP_002476	O60934	NBN_HUMAN	nibrin	536					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			central_nervous_system(3)|kidney(3)|lung(1)	7			BRCA - Breast invasive adenocarcinoma(11;0.0344)			GAGATTTACTGGCAGAATTTT	0.348			NA						Direct_reversal_of_damage|Homologous_recombination	Nijmegen_Breakage_syndrome				21	46	---	---	---	---	NA	NA	NA	NA	NA
ESRP1	54845	broad.mit.edu	37	8	95653626	95653628	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	AGA	AGA	-	-	AGA	AGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:95653626_95653628delAGA	uc003ygq.3	+	1	263_265	c.80_82delAGA	c.(79-84)GAGAAG>GAG	p.K28del	ESRP1_uc003ygr.3_In_Frame_Del_p.K28del|ESRP1_uc003ygs.3_In_Frame_Del_p.K28del|ESRP1_uc003ygt.3_In_Frame_Del_p.K28del|ESRP1_uc003ygu.3_In_Frame_Del_p.K28del	NM_017697	NP_060167	Q6NXG1	ESRP1_HUMAN	RNA binding motif protein 35A isoform 1	28					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	prostate(4)	4						GGCTCGGATGAGAAGGAGTTGAT	0.532			NA											20	46	---	---	---	---	NA	NA	NA	NA	NA
EPPK1	83481	broad.mit.edu	37	8	144945106	144945106	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:144945106delC	uc003zaa.1	-	1	2329	c.2316delG	c.(2314-2316)ACGfs	p.T772fs		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	772	Plectin 15.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGTTCTCGTGCGTGTTGGGGT	0.627			NA											34	56	---	---	---	---	NA	NA	NA	NA	NA
ZNF251	90987	broad.mit.edu	37	8	145947348	145947358	+	Frame_Shift_Del	DEL	AAGGATTTCTC	AAGGATTTCTC	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	AAGGATTTCTC	AAGGATTTCTC	-	-	AAGGATTTCTC	AAGGATTTCTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr8:145947348_145947358delAAGGATTTCTC	uc003zdv.3	-	5	1943_1953	c.1687_1697delGAGAAATCCTT	c.(1687-1698)GAGAAATCCTTTfs	p.E563fs		NM_138367	NP_612376	Q9BRH9	ZN251_HUMAN	zinc finger protein 251	563_566	C2H2-type 12; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.54e-11)|all_epithelial(106;2.65e-10)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.75e-39)|Epithelial(56;7.54e-38)|all cancers(56;6.19e-33)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.11)	GBM - Glioblastoma multiforme(99;0.198)		ATTACATCCAAAGGATTTCTCACCAGTGTGA	0.469			NA											27	46	---	---	---	---	NA	NA	NA	NA	NA
PTPRD	5789	broad.mit.edu	37	9	8528692	8528692	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:8528692delC	uc003zkk.2	-	14	1151	c.440delG	c.(439-441)TGTfs	p.C147fs	PTPRD_uc003zkp.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zkq.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zkr.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zks.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zkl.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zkm.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zkn.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zko.2_Frame_Shift_Del_p.C147fs|PTPRD_uc003zkt.1_Frame_Shift_Del_p.C147fs	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	147	Extracellular (Potential).|Ig-like C2-type 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACTGGCTGCACAAAGCATGGT	0.473			NA								TSP Lung(15;0.13)			40	16	---	---	---	---	NA	NA	NA	NA	NA
RECK	8434	broad.mit.edu	37	9	36087832	36087833	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	TT	TT	-	-	TT	TT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:36087832_36087833delTT	uc003zyv.2	+	9	865_866	c.779_780delTT	c.(778-780)CTTfs	p.L260fs	RECK_uc003zyw.2_Frame_Shift_Del_p.L132fs|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	260	Knot 4.|5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity	p.L260F(1)		skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CAAGATCCTCTTTGGCAATGTT	0.475			NA											15	46	---	---	---	---	NA	NA	NA	NA	NA
ZBTB5	9925	broad.mit.edu	37	9	37440624	37440625	+	Frame_Shift_Ins	INS	-	-	CTTA	rs11558453		TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:37440624_37440625insCTTA	uc003zzx.2	-	2	2124_2125	c.1924_1925insTAAG	c.(1924-1926)GCCfs	p.A642fs		NM_014872	NP_055687	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	642	C2H2-type 2; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		CTTCAGGCAGGCGTAAGGCTTT	0.505			NA											27	51	---	---	---	---	NA	NA	NA	NA	NA
ZNF484	83744	broad.mit.edu	37	9	95608548	95608548	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chr9:95608548delC	uc004asu.1	-	5	2670	c.2521delG	c.(2521-2523)GACfs	p.D841fs	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Frame_Shift_Del_p.D843fs|ZNF484_uc010mrb.1_Frame_Shift_Del_p.D805fs|ZNF484_uc004asv.1_Frame_Shift_Del_p.D805fs	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	841					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCTTCTGAGTCCCCACACCAT	0.438			NA											88	24	---	---	---	---	NA	NA	NA	NA	NA
SRPX	8406	broad.mit.edu	37	X	38016264	38016264	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:38016264delC	uc004ddy.1	-	8	1060	c.974delG	c.(973-975)GGTfs	p.G325fs	SRPX_uc004ddz.1_Frame_Shift_Del_p.G305fs|SRPX_uc011mkh.1_Frame_Shift_Del_p.G266fs|SRPX_uc011mki.1_Frame_Shift_Del_p.G325fs	NM_006307	NP_006298	P78539	SRPX_HUMAN	sushi-repeat-containing protein, X-linked	325					cell adhesion	cell surface|membrane					0						CGTTCTGACACCCACATTGAC	0.498			NA											30	17	---	---	---	---	NA	NA	NA	NA	NA
TGIF2LX	90316	broad.mit.edu	37	X	89177718	89177718	+	Frame_Shift_Del	DEL	G	G	-	rs149582592	byFrequency	TCGA-78-7155-01A-11D-2036-08	TCGA-78-7155-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	cf7882fa-4343-4c32-8940-2fc85cfb4c6e	14233f2d-dd7b-4330-a079-0f7158397e28	g.chrX:89177718delG	uc004efe.2	+	2	683	c.634delG	c.(634-636)GCCfs	p.A212fs		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	212						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AGAGGAGCACGCCGACTTCAG	0.532			NA											10	7	---	---	---	---	NA	NA	NA	NA	NA