Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTOR	2475	broad.mit.edu	37	1	11300433	11300433	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:11300433C>A	uc001asd.2	-	11	1834	c.1713G>T	c.(1711-1713)ACG>ACT	p.T571T		NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	571					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						CAGGGAGGGTCGTGAGGCCAG	0.577			NA											20	37					2.94398e-08	4.7036e-08	0.007413	1	0
UBIAD1	29914	broad.mit.edu	37	1	11333865	11333865	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:11333865G>T	uc001asg.2	+	1	611	c.277G>T	c.(277-279)GCT>TCT	p.A93S		NM_013319	NP_037451	Q9Y5Z9	UBIA1_HUMAN	UbiA prenyltransferase domain containing 1	93	Helical; (Potential).				menaquinone biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrion|nucleus	prenyltransferase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000818)|all_lung(284;0.00105)|Colorectal(325;0.0062)|Breast(348;0.012)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.52e-06)|COAD - Colon adenocarcinoma(227;0.000254)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0487)		GGCTGTCCTGGCTGTGCACGG	0.562			NA											42	56					3.54909e-21	7.18432e-21	0.002852	1	0
IGSF21	84966	broad.mit.edu	37	1	18703331	18703331	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:18703331G>T	uc001bau.1	+	8	1522	c.1139G>T	c.(1138-1140)CGG>CTG	p.R380L	IGSF21_uc001bav.1_Missense_Mutation_p.R201L	NM_032880	NP_116269	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21 precursor	380	Ig-like 2.					extracellular region				ovary(2)|large_intestine(1)|skin(1)	4		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		ACGTGGACGCGGGTTGGGAGC	0.642			NA											17	14					6.94344e-10	1.19153e-09	0.006122	1	0
TAS1R2	80834	broad.mit.edu	37	1	19180775	19180775	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:19180775G>T	uc001bba.1	-	3	1190	c.1189C>A	c.(1189-1191)CAT>AAT	p.H397N		NM_152232	NP_689418	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2 precursor	397	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	TGCAGGGCATGGGCCACAGCA	0.607			NA											10	18					3.07112e-06	4.64006e-06	0.000978	1	0
ZBTB40	9923	broad.mit.edu	37	1	22839540	22839540	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:22839540G>A	uc001bft.2	+	13	3096	c.2585G>A	c.(2584-2586)CGC>CAC	p.R862H	ZBTB40_uc001bfu.2_Missense_Mutation_p.R862H|ZBTB40_uc009vqi.1_Missense_Mutation_p.R750H	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	862					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		ACCGGGGACCGCCCGTTCATG	0.577			NA											6	25					0	0	0.001168	0	0
NFYC	4802	broad.mit.edu	37	1	41232320	41232320	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:41232320C>G	uc001cge.2	+	7	781	c.773C>G	c.(772-774)TCA>TGA	p.S258*	NFYC_uc010ojm.1_Nonsense_Mutation_p.S164*|NFYC_uc001cfx.3_Nonsense_Mutation_p.S258*|NFYC_uc009vwd.2_Nonsense_Mutation_p.S258*|NFYC_uc001cfz.2_Nonsense_Mutation_p.S258*|NFYC_uc010ojn.1_Nonsense_Mutation_p.S220*|NFYC_uc001cfy.3_Nonsense_Mutation_p.S258*|NFYC_uc001cgc.2_Nonsense_Mutation_p.S224*|NFYC_uc001cgb.2_Nonsense_Mutation_p.S258*|NFYC_uc001cgd.3_Nonsense_Mutation_p.S258*	NM_001142588	NP_001136060	Q13952	NFYC_HUMAN	nuclear transcription factor Y, gamma isoform 1	258					protein folding|regulation of transcription from RNA polymerase II promoter	CCAAT-binding factor complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|kidney(1)	3	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.72e-17)			CAGCCTGTATCAGGCACTCAA	0.537			NA											7	29					0	0	0.006214	0	0
CYP4X1	260293	broad.mit.edu	37	1	47489498	47489498	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:47489498C>G	uc001cqt.2	+	1	259	c.9C>G	c.(7-9)TTC>TTG	p.F3L	CYP4X1_uc001cqr.2_Intron|CYP4X1_uc001cqs.2_Intron	NM_178033	NP_828847	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X,	3						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)|skin(1)	2						CCATGGAATTCTCCTGGCTGG	0.697			NA											3	29					0	0	0.000248	0	0
PTGER3	5733	broad.mit.edu	37	1	71512943	71512943	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:71512943G>A	uc001dfg.1	-	1	549	c.318C>T	c.(316-318)ACC>ACT	p.T106T	PTGER3_uc001dfh.1_RNA|PTGER3_uc001dfi.1_RNA|PTGER3_uc001dfj.1_RNA|PTGER3_uc001dfk.1_Silent_p.T106T|PTGER3_uc001dfl.1_Silent_p.T106T|PTGER3_uc009wbm.1_Silent_p.T106T|PTGER3_uc001dfm.1_RNA|PTGER3_uc001dfn.2_Silent_p.T106T|PTGER3_uc009wbn.1_Silent_p.T106T|PTGER3_uc009wbo.2_Silent_p.T106T|PTGER3_uc001dfo.2_Silent_p.T106T|PTGER3_uc001dfp.1_Silent_p.T106T|PTGER3_uc001dfq.2_Silent_p.T106T|uc001dfr.2_RNA	NM_198714	NP_942007	P43115	PE2R3_HUMAN	prostaglandin E receptor 3, subtype EP3 isoform	106	Helical; Name=2; (Potential).				cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			pancreas(1)|lung(1)|skin(1)	3					Bimatoprost(DB00905)	CGACCGGGGTGGTGAGAAGCT	0.642			NA											3	5					0	0	0.004672	0	0
GPSM2	29899	broad.mit.edu	37	1	109441561	109441561	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:109441561C>T	uc010ovc.1	+	7	1238	c.742C>T	c.(742-744)CTT>TTT	p.L248F	AKNAD1_uc010ovb.1_Intron|GPSM2_uc010ovd.1_Missense_Mutation_p.L248F|GPSM2_uc010ove.1_Missense_Mutation_p.L248F	NM_013296	NP_037428	P81274	GPSM2_HUMAN	LGN protein	248	TPR 6.				G-protein coupled receptor protein signaling pathway	cell cortex|nucleus	GTPase activator activity|identical protein binding			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)		Colorectal(144;0.0353)|Lung(183;0.0984)|COAD - Colon adenocarcinoma(174;0.129)|Epithelial(280;0.175)|all cancers(265;0.209)		ATATAGCAACCTTGGAAATGC	0.299			NA											15	19					0	0	0.00245	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244			NA											6	120					0	0	0.001168	0	0
CRNN	49860	broad.mit.edu	37	1	152383274	152383274	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:152383274C>T	uc001ezx.2	-	3	358	c.284G>A	c.(283-285)GGA>GAA	p.G95E		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	95					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCGCAGGCTCCCTCAGCACT	0.562			NA											16	314					0	0	0.006122	0	0
KPRP	448834	broad.mit.edu	37	1	152732360	152732360	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:152732360C>A	uc001fal.1	+	2	354	c.296C>A	c.(295-297)GCA>GAA	p.A99E		NM_001025231	NP_001020402	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	99	Gln-rich.					cytoplasm				ovary(4)|pancreas(1)	5	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCCAGGCTGCATCCCAATCT	0.542			NA											74	245					9.53419e-23	1.9585e-22	0.00361	1	0
NUP210L	91181	broad.mit.edu	37	1	153974346	153974346	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:153974346C>A	uc001fdw.2	-	36	5118	c.5046G>T	c.(5044-5046)AAG>AAT	p.K1682N	NUP210L_uc009woq.2_Missense_Mutation_p.K591N|NUP210L_uc010peh.1_Intron	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	1682						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			GCATTCCATTCTTGCTACGTT	0.478			NA											73	81					2.23852e-25	4.71447e-25	0.00361	1	0
C1orf43	25912	broad.mit.edu	37	1	154192836	154192836	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:154192836C>T	uc001fei.2	-	1	438	c.48G>A	c.(46-48)GTG>GTA	p.V16V	C1orf43_uc001feg.2_Silent_p.V16V|C1orf43_uc001feh.2_Silent_p.V16V|C1orf43_uc001fej.2_Silent_p.V16V|C1orf43_uc009wos.1_Silent_p.V16V|C1orf43_uc001fek.2_Silent_p.V16V|C1orf43_uc001fel.2_Silent_p.V16V|UBAP2L_uc009wot.2_Intron|UBAP2L_uc010pek.1_5'Flank|UBAP2L_uc001fep.3_5'Flank|UBAP2L_uc010pel.1_5'Flank|UBAP2L_uc001fen.1_5'Flank|UBAP2L_uc010pem.1_5'Flank	NM_001098616	NP_001092086	Q9BWL3	CA043_HUMAN	hypothetical protein LOC25912 isoform 3	16	Helical; (Potential).					integral to membrane	coenzyme binding|oxidoreductase activity				0	all_lung(78;1.98e-30)|Lung NSC(65;2.87e-28)|Hepatocellular(266;0.0877)					CGTAGGCCATCACCAGCACGA	0.602			NA											33	137					0	0	0.002836	0	0
UBAP2L	9898	broad.mit.edu	37	1	154233427	154233427	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:154233427G>T	uc001fep.3	+	23	2805	c.2638G>T	c.(2638-2640)GCC>TCC	p.A880S	UBAP2L_uc009wot.2_Missense_Mutation_p.A880S|UBAP2L_uc010pek.1_Missense_Mutation_p.A872S|UBAP2L_uc010pel.1_Missense_Mutation_p.A890S|UBAP2L_uc010pen.1_Missense_Mutation_p.A794S|UBAP2L_uc001feq.2_Missense_Mutation_p.A76S|UBAP2L_uc001fer.2_Missense_Mutation_p.A76S	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	880					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACAACCTTGGCCCAACCCCA	0.597			NA											22	83					3.28513e-13	5.95608e-13	0.003954	1	0
OR6Y1	391112	broad.mit.edu	37	1	158516940	158516940	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:158516940C>A	uc010pil.1	-	1	956	c.956G>T	c.(955-957)GGA>GTA	p.G319V		NM_001005189	NP_001005189	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y,	319	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					AGCCCCATTTCCCTGGGGCCC	0.448			NA											23	89					2.89027e-11	5.12869e-11	0.002299	1	0
DCAF8	50717	broad.mit.edu	37	1	160249886	160249886	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:160249886C>G	uc010pjc.1	-	4	576	c.304G>C	c.(304-306)GAG>CAG	p.E102Q	PEX19_uc010pje.1_RNA|PEX19_uc001fvs.2_Missense_Mutation_p.E249Q|PEX19_uc001fvt.2_Missense_Mutation_p.E159Q	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	Error:Variant_position_missing_in_Q5TAQ9_after_alignment						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						AGCACCATCTCAAAACGAGCC	0.493			NA											8	277					0	0	0.00308	0	0
TNN	63923	broad.mit.edu	37	1	175086284	175086284	+	Missense_Mutation	SNP	G	G	T	rs147066934		TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:175086284G>T	uc001gkl.1	+	10	2442	c.2329G>T	c.(2329-2331)GTG>TTG	p.V777L		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	777	Fibronectin type-III 6.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CACGGTGCACGTGTGGGCCCA	0.592			NA											21	88					2.4624e-09	4.15716e-09	0.008871	1	0
CEP350	9857	broad.mit.edu	37	1	180000550	180000550	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:180000550A>C	uc001gnt.2	+	15	4029	c.3646A>C	c.(3646-3648)AGC>CGC	p.S1216R	CEP350_uc009wxl.2_Missense_Mutation_p.S1215R|CEP350_uc001gnu.2_Missense_Mutation_p.S1049R	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1216	Ser-rich.					centrosome|nucleus|spindle				ovary(4)	4						TGGGACCAGCAGCAAACTTTC	0.398			NA											6	28					0	0	0.001168	0	0
CACNA1E	777	broad.mit.edu	37	1	181721322	181721322	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:181721322G>T	uc001gow.2	+	27	3940	c.3775G>T	c.(3775-3777)GTG>TTG	p.V1259L	CACNA1E_uc009wxs.2_Missense_Mutation_p.V1147L|CACNA1E_uc001gox.1_Missense_Mutation_p.V485L|CACNA1E_uc009wxt.2_Missense_Mutation_p.V485L	NM_000721	NP_000712	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type,	1259	III.|Helical; Name=S4 of repeat III.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6						GTCTCTGCGGGTGCTCCGAGT	0.498			NA											22	87					9.80776e-20	1.94754e-19	0.00632	1	0
LAMC2	3918	broad.mit.edu	37	1	183212376	183212376	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:183212376G>T	uc001gqa.2	+	23	3737	c.3423G>T	c.(3421-3423)ATG>ATT	p.M1141I		NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1141	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						TGCGGCCCATGATGTCAGAGC	0.537			NA											56	60					5.99346e-17	1.15174e-16	0.00361	1	0
RPS6KC1	26750	broad.mit.edu	37	1	213414361	213414361	+	Silent	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:213414361A>G	uc010ptr.1	+	11	1701	c.1542A>G	c.(1540-1542)ACA>ACG	p.T514T	RPS6KC1_uc001hkd.2_Silent_p.T502T|RPS6KC1_uc010pts.1_Silent_p.T302T|RPS6KC1_uc010ptt.1_Silent_p.T302T|RPS6KC1_uc010ptu.1_Silent_p.T333T|RPS6KC1_uc010ptv.1_Silent_p.T49T|RPS6KC1_uc001hke.2_Silent_p.T333T	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	514					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		GTTATTTAACATTATGCAATG	0.398			NA											23	28					0	0	0.003954	0	0
USH2A	7399	broad.mit.edu	37	1	215987179	215987179	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:215987179G>T	uc001hku.1	-	49	10025	c.9638C>A	c.(9637-9639)CCG>CAG	p.P3213Q		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3213	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAGAACAAACGGGATATACTT	0.418			NA								HNSCC(13;0.011)			27	62					1.33986e-20	2.68617e-20	0.004656	1	0
USH2A	7399	broad.mit.edu	37	1	216373289	216373289	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:216373289G>T	uc001hku.1	-	17	3878	c.3491C>A	c.(3490-3492)TCT>TAT	p.S1164Y	USH2A_uc001hkv.2_Missense_Mutation_p.S1164Y	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1164	Extracellular (Potential).|Fibronectin type-III 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGTGTCACAGAGTCTGAGCC	0.448			NA								HNSCC(13;0.011)			102	50					2.07245e-51	4.828e-51	0.00361	1	0
DISP1	84976	broad.mit.edu	37	1	223178606	223178606	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:223178606G>T	uc001hnu.1	+	8	4014	c.3867G>T	c.(3865-3867)CAG>CAT	p.Q1289H		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	1289					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		CTTGCCAGCAGATGGGGGACT	0.532			NA											63	173					4.09106e-26	8.74858e-26	0.00361	1	0
HEATR1	55127	broad.mit.edu	37	1	236751262	236751262	+	Missense_Mutation	SNP	T	T	C	rs149485004	byFrequency	TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:236751262T>C	uc001hyd.1	-	13	1737	c.1612A>G	c.(1612-1614)ATA>GTA	p.I538V		NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	538					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AAAGCACTTATAGCCGACAAA	0.348			NA											37	18					0	0	0.005524	0	0
ZP4	57829	broad.mit.edu	37	1	238048735	238048735	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:238048735G>T	uc001hym.2	-	8	1116	c.1116C>A	c.(1114-1116)AGC>AGA	p.S372R	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	372	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGGGGTCAGTGCTGGGTGTTG	0.532	NSCLC(166;160 2029 11600 18754 19936)		NA											23	69					1.22574e-08	1.99661e-08	0.002299	1	0
EXO1	9156	broad.mit.edu	37	1	242013757	242013757	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:242013757C>G	uc001hzh.2	+	4	570	c.30C>G	c.(28-30)ATC>ATG	p.I10M	EXO1_uc001hzi.2_Missense_Mutation_p.I10M|EXO1_uc001hzj.2_Missense_Mutation_p.I10M|EXO1_uc009xgq.2_Missense_Mutation_p.I10M	NM_130398	NP_569082	Q9UQ84	EXO1_HUMAN	exonuclease 1 isoform b	10	N-domain.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			ovary(2)|lung(2)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			TACAATTTATCAAAGAAGCTT	0.388			NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					5	86					0	0	0.001168	0	0
OR2G6	391211	broad.mit.edu	37	1	248685673	248685673	+	Silent	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:248685673G>T	uc001ien.1	+	1	726	c.726G>T	c.(724-726)TCG>TCT	p.S242S		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GGACCTGTTCGTCTCACCTGG	0.463			NA											28	103					1.39806e-14	2.63796e-14	0.008361	1	0
WDR37	22884	broad.mit.edu	37	10	1130413	1130413	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:1130413G>T	uc001igf.1	+	6	640	c.467G>T	c.(466-468)CGG>CTG	p.R156L	WDR37_uc001ige.2_Missense_Mutation_p.R156L|WDR37_uc009xhm.1_Missense_Mutation_p.R156L|WDR37_uc009xhn.1_RNA|WDR37_uc001igg.1_RNA	NM_014023	NP_054742	Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	156	WD 1.										0		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		ATCGGCCACCGGGACGGCATC	0.597			NA											19	30					5.03518e-11	8.85937e-11	0.007413	1	0
ITGA8	8516	broad.mit.edu	37	10	15760819	15760819	+	Missense_Mutation	SNP	G	G	T	rs35729957		TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:15760819G>T	uc001ioc.1	-	2	289	c.289C>A	c.(289-291)CCT>ACT	p.P97T	ITGA8_uc010qcb.1_Missense_Mutation_p.P97T	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor	97	Extracellular (Potential).|FG-GAP 1.				cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.P97T(1)		ovary(3)|lung(3)	6						GCGGGCCAAGGACAGTAATAG	0.572			NA											28	45					3.80469e-20	7.59118e-20	0.001786	1	0
PLXDC2	84898	broad.mit.edu	37	10	20436785	20436785	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:20436785A>G	uc001iqg.1	+	6	1374	c.737A>G	c.(736-738)CAG>CGG	p.Q246R	PLXDC2_uc001iqh.1_Missense_Mutation_p.Q197R|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	246	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TTCACATTCCAGGCAACCCTG	0.438			NA											3	36					0	0	0.004672	0	0
PLXDC2	84898	broad.mit.edu	37	10	20508007	20508007	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:20508007G>A	uc001iqg.1	+	12	1925	c.1288G>A	c.(1288-1290)GCA>ACA	p.A430T	PLXDC2_uc001iqh.1_Missense_Mutation_p.A381T|PLXDC2_uc009xkc.1_RNA	NM_032812	NP_116201	Q6UX71	PXDC2_HUMAN	plexin domain containing 2 precursor	430	Extracellular (Potential).					integral to membrane				ovary(2)|central_nervous_system(1)|skin(1)	4						TACCAAGATAGCACTACATCT	0.284			NA											5	12					0	0	0.000602	0	0
FZD8	8325	broad.mit.edu	37	10	35930182	35930182	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:35930182T>A	uc001iyz.1	-	1	181	c.176A>T	c.(175-177)CAC>CTC	p.H59L		NM_031866	NP_114072	Q9H461	FZD8_HUMAN	frizzled 8 precursor	59	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding				0						TTGCGTGTCGTGGTTGAACTG	0.607			NA											12	19					0	0	0.001368	0	0
C10orf71	118461	broad.mit.edu	37	10	50530874	50530874	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:50530874G>T	uc010qgp.1	+	3	623	c.284G>T	c.(283-285)TGG>TTG	p.W95L		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	95											0						CATTCGGGCTGGGCGGCCACC	0.577			NA											30	41					1.45844e-13	2.6674e-13	0.002836	1	0
BICC1	80114	broad.mit.edu	37	10	60546724	60546724	+	Silent	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:60546724A>G	uc001jki.1	+	5	429	c.429A>G	c.(427-429)GAA>GAG	p.E143E		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	143	KH 1.				multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						CACATACAGAACATTCACATG	0.368			NA											8	24					0	0	0.00308	0	0
FAM13C	220965	broad.mit.edu	37	10	61043179	61043179	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:61043179T>A	uc001jkn.2	-	7	670	c.536A>T	c.(535-537)AAG>ATG	p.K179M	FAM13C_uc001jko.2_Missense_Mutation_p.K179M|FAM13C_uc010qid.1_Missense_Mutation_p.K96M|FAM13C_uc010qie.1_Missense_Mutation_p.K96M|FAM13C_uc010qif.1_Missense_Mutation_p.K201M|FAM13C_uc001jkp.2_Missense_Mutation_p.K96M	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	179										ovary(2)	2						CGCCGGGTCCTTGACTCCATG	0.532			NA											56	69					0	0	0.00361	0	0
COL17A1	1308	broad.mit.edu	37	10	105792028	105792028	+	Silent	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:105792028G>T	uc001kxr.2	-	56	4628	c.4459C>A	c.(4459-4461)CGG>AGG	p.R1487R	COL17A1_uc001kxq.2_RNA	NM_000494	NP_000485	Q9UMD9	COHA1_HUMAN	alpha 1 type XVII collagen	1487	Extracellular (Potential).|Nonhelical region (NC1).				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CTCCTTCTCCGCCCAGCATAG	0.498			NA											15	18					7.93312e-07	1.21622e-06	0.00245	1	0
SORCS3	22986	broad.mit.edu	37	10	107016584	107016584	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:107016584G>C	uc001kyi.1	+	25	3572	c.3345G>C	c.(3343-3345)TTG>TTC	p.L1115F		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	1115	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		AAGCTCCATTGGTGGACTCCA	0.458	NSCLC(116;1497 1690 7108 13108 14106)		NA											13	16					0	0	0.001368	0	0
EMX2	2018	broad.mit.edu	37	10	119305203	119305203	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:119305203G>A	uc001ldh.3	+	2	1290	c.467G>A	c.(466-468)CGG>CAG	p.R156Q	EMX2OS_uc001ldg.2_5'Flank|EMX2_uc001ldi.3_Intron	NM_004098	NP_004089	Q04743	EMX2_HUMAN	empty spiracles homeobox 2 isoform 1	156	Homeobox.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Colorectal(252;0.109)|Lung NSC(174;0.179)|all_lung(145;0.22)		all cancers(201;0.0133)		AAGCCCAAGCGGATCCGAACC	0.607			NA											4	29					0	0	0.000602	0	0
RGS10	6001	broad.mit.edu	37	10	121285608	121285608	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr10:121285608C>G	uc001lee.2	-	2	167	c.167G>C	c.(166-168)AGT>ACT	p.S56T	RGS10_uc001lef.2_Missense_Mutation_p.S50T|RGS10_uc001leg.2_Missense_Mutation_p.S64T	NM_002925	NP_002916	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform b	56	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		ATTTTCTTCACTGAATTCCTT	0.299			NA											16	35					0	0	0.00499	0	0
OR52R1	119695	broad.mit.edu	37	11	4825267	4825267	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:4825267G>T	uc010qym.1	-	1	581	c.581C>A	c.(580-582)TCT>TAT	p.S194Y		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	115	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GAGCACCCCAGACTCCACAGA	0.527			NA											38	40					7.61001e-30	1.6702e-29	0.005524	1	0
TRIM22	10346	broad.mit.edu	37	11	5730492	5730492	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:5730492G>T	uc001mbr.2	+	8	1388	c.1111G>T	c.(1111-1113)GTA>TTA	p.V371L	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron|TRIM22_uc009yes.2_Missense_Mutation_p.V367L|TRIM22_uc010qzm.1_Missense_Mutation_p.V199L|TRIM22_uc009yeu.2_Missense_Mutation_p.V182L|OR56B1_uc001mbs.1_Intron|OR56B1_uc009yev.1_Intron	NM_006074	NP_006065	Q8IYM9	TRI22_HUMAN	tripartite motif-containing 22	371	B30.2/SPRY.				immune response|interspecies interaction between organisms|protein trimerization|response to virus	Cajal body|Golgi apparatus|nuclear speck	ligase activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding				0		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;7.54e-09)|BRCA - Breast invasive adenocarcinoma(625;0.14)		GATCCTGGGCGTACACAGTAA	0.393	GBM(104;491 2336 5222)		NA											24	32					1.64293e-13	2.99172e-13	0.00333	1	0
OR52E4	390081	broad.mit.edu	37	11	5905530	5905530	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:5905530C>A	uc010qzs.1	+	1	8	c.8C>A	c.(7-9)TCT>TAT	p.S3Y	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	3	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAATGCCTTCTATCAATGAC	0.428			NA											44	70					8.86878e-18	1.72817e-17	0.00361	1	0
INSC	387755	broad.mit.edu	37	11	15222462	15222462	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:15222462C>T	uc001mly.2	+	7	973	c.927C>T	c.(925-927)TGC>TGT	p.C309C	INSC_uc001mlz.2_Silent_p.C262C|INSC_uc001mma.2_Silent_p.C262C|INSC_uc010rcs.1_Silent_p.C297C|INSC_uc001mmb.2_Silent_p.C262C|INSC_uc001mmc.2_Intron	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	309					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CCTCCATCTGCTGCGTGGAAG	0.632			NA											4	2					0	0	0.000248	0	0
INSC	387755	broad.mit.edu	37	11	15260597	15260597	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:15260597C>G	uc001mly.2	+	11	1557	c.1511C>G	c.(1510-1512)GCA>GGA	p.A504G	INSC_uc001mlz.2_Missense_Mutation_p.A457G|INSC_uc001mma.2_Missense_Mutation_p.A457G|INSC_uc010rcs.1_Missense_Mutation_p.A492G|INSC_uc001mmb.2_Missense_Mutation_p.A457G|INSC_uc001mmc.2_Missense_Mutation_p.A415G	NM_001031853	NP_001027024	Q1MX18	INSC_HUMAN	inscuteable isoform a	504					cell differentiation|nervous system development	cytoplasm	binding			upper_aerodigestive_tract(2)|ovary(2)|central_nervous_system(1)	5						CCAGATGTGGCACGGGAGGCC	0.617			NA											13	20					0	0	0.001368	0	0
SLC17A6	57084	broad.mit.edu	37	11	22399051	22399051	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:22399051G>T	uc001mqk.2	+	12	1927	c.1514G>T	c.(1513-1515)TGG>TTG	p.W505L		NM_020346	NP_065079	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (sodium-dependent	505	Cytoplasmic (Potential).				sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)|breast(1)	4						AAACAACCCTGGGCAGACCCG	0.403			NA											9	17					7.48243e-07	1.15136e-06	0.006214	1	0
EXT2	2132	broad.mit.edu	37	11	44254029	44254029	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:44254029G>A	uc001mxz.2	+	11	2123	c.1789G>A	c.(1789-1791)GCA>ACA	p.A597T	EXT2_uc010rfo.1_Missense_Mutation_p.A625T|EXT2_uc001mxy.2_Missense_Mutation_p.A610T|EXT2_uc009ykt.2_Missense_Mutation_p.A607T|EXT2_uc001mya.2_Missense_Mutation_p.A630T	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	597	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						GCTCACTGGGGCAGCTTTTTA	0.463			NA	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				12	18					0	0	0.001368	0	0
MS4A13	503497	broad.mit.edu	37	11	60296836	60296836	+	Splice_Site	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:60296836A>G	uc001nps.2	+	6	630	c.307_splice	c.e6-2	p.K103_splice	MS4A13_uc009ync.2_Splice_Site_p.K63_splice|MS4A13_uc009ynd.2_Splice_Site_p.K44_splice	NM_001012417	NP_001012417	Q5J8X5	M4A13_HUMAN	membrane-spanning 4-domains, subfamily A, member							integral to membrane					0						TTTTGGTTATAGAAACTTGGG	0.343			NA											11	23					0	0	0.000978	0	0
DAGLA	747	broad.mit.edu	37	11	61495745	61495745	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:61495745G>A	uc001nsa.2	+	7	868	c.757G>A	c.(757-759)GCC>ACC	p.A253T		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	253	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		CAAGCGCAACGCCGTGCTGGA	0.647			NA											24	51					0	0	0.005443	0	0
ODZ4	26011	broad.mit.edu	37	11	78440614	78440614	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:78440614G>A	uc001ozl.3	-	22	3676	c.3213C>T	c.(3211-3213)TAC>TAT	p.Y1071Y		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1071	Extracellular (Potential).				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						GGACAGATTTGTAGCCAGGGG	0.567			NA											22	25					0	0	0.001882	0	0
RAB30	27314	broad.mit.edu	37	11	82693351	82693351	+	Silent	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:82693351A>G	uc001ozu.2	-	6	729	c.468T>C	c.(466-468)TCT>TCC	p.S156S	RAB30_uc009yve.2_Silent_p.S154S|RAB30_uc010rst.1_Silent_p.S154S|RAB30_uc001ozv.2_Missense_Mutation_p.L153P	NM_014488	NP_055303	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	156					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity				0						CCACATTATCAGATTCCTTGG	0.473			NA											3	57					0	0	0.000248	0	0
MMP13	4322	broad.mit.edu	37	11	102815025	102815025	+	Silent	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:102815025G>T	uc001phl.2	-	10	1414	c.1386C>A	c.(1384-1386)GTC>GTA	p.V462V		NM_002427	NP_002418	P45452	MMP13_HUMAN	matrix metalloproteinase 13 preproprotein	462	Hemopexin-like 4.				collagen catabolic process|proteolysis	extracellular space	metalloendopeptidase activity|zinc ion binding	p.V462I(1)		ovary(2)|skin(1)	3		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0144)		TTGCTGGCATGACGCGAACAA	0.358			NA											56	85					4.73848e-44	1.08568e-43	0.00361	1	0
DDI1	414301	broad.mit.edu	37	11	103907842	103907842	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:103907842G>A	uc001phr.2	+	1	535	c.292G>A	c.(292-294)GGC>AGC	p.G98S	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	98					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AGACTTCAGTGGCATTGCGGT	0.642			NA											43	54					0	0	0.002222	0	0
CEP164	22897	broad.mit.edu	37	11	117253620	117253620	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:117253620G>T	uc001prc.2	+	14	1833	c.1686G>T	c.(1684-1686)AAG>AAT	p.K562N	CEP164_uc001prb.2_Missense_Mutation_p.K565N|CEP164_uc010rxk.1_Missense_Mutation_p.K536N|CEP164_uc001prf.2_RNA|CEP164_uc009yzp.1_RNA|CEP164_uc001prg.1_5'Flank	NM_014956	NP_055771	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	562	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		CTGAGGAGAAGGTGGCGGTCA	0.642			NA											13	14					5.50884e-06	8.26326e-06	0.001368	1	0
DSCAML1	57453	broad.mit.edu	37	11	117387188	117387188	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:117387188C>A	uc001prh.1	-	8	1959	c.1957G>T	c.(1957-1959)GTC>TTC	p.V653F		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	593	Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CTACCTTTGACGGCTACGTGA	0.617			NA											9	19					6.40141e-05	9.33353e-05	0.000978	1	0
FOXR1	283150	broad.mit.edu	37	11	118851416	118851416	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:118851416C>A	uc001pui.2	+	5	1053	c.828C>A	c.(826-828)ATC>ATA	p.I276I	FOXR1_uc001puj.2_RNA|FOXR1_uc001puk.2_Silent_p.I107I	NM_181721	NP_859072	Q6PIV2	FOXR1_HUMAN	forkhead box R1	276					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(1)	1	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TAGAAAGTATCCAACAGTGCA	0.612			NA											14	14					1.5842e-08	2.56051e-08	0.001855	1	0
SPA17	53340	broad.mit.edu	37	11	124564341	124564341	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:124564341G>A	uc001qap.2	+	5	591	c.455G>A	c.(454-456)TGA>TAA	p.*152*		NM_017425	NP_059121	Q15506	SP17_HUMAN	sperm autoantigenic protein 17	152					binding of sperm to zona pellucida|ciliary or flagellar motility|signal transduction|spermatogenesis	cytoplasm|flagellum|membrane|motile cilium|primary cilium	cAMP-dependent protein kinase regulator activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0223)		GAAAACAAGTGAGGACACTGG	0.388			NA											13	60					0	0	0.001368	0	0
OVCH1	341350	broad.mit.edu	37	12	29648354	29648354	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr12:29648354C>A	uc001rix.1	-	4	318	c.318G>T	c.(316-318)GAG>GAT	p.E106D		NM_183378	NP_899234	Q7RTY7	OVCH1_HUMAN	ovochymase 1 precursor	106	Peptidase S1 1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			ovary(3)|central_nervous_system(3)|pancreas(3)|large_intestine(1)	10	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AGAGGCTGTACTCCCCAGAAG	0.378			NA											19	32					2.94398e-08	4.7036e-08	0.007413	1	0
ALX1	8092	broad.mit.edu	37	12	85677598	85677598	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr12:85677598G>T	uc001tae.3	+	2	479	c.475G>T	c.(475-477)GTG>TTG	p.V159L		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	159	Homeobox.				brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TTACCCGGATGTGTATGTCAG	0.493			NA											32	48					1.30293e-26	2.81515e-26	0.003271	1	0
POLR3B	55703	broad.mit.edu	37	12	106772119	106772119	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr12:106772119G>A	uc001tlp.2	+	8	793	c.571G>A	c.(571-573)GTG>ATG	p.V191M	POLR3B_uc001tlq.2_Missense_Mutation_p.V133M	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	191					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						CAGGATCATCGTGGAGGCTGA	0.408			NA											7	93					0	0	0.001984	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138920	126138920	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr12:126138920G>C	uc001uhe.1	+	9	2909	c.2901G>C	c.(2899-2901)GAG>GAC	p.E967D	TMEM132B_uc001uhf.1_Missense_Mutation_p.E479D	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	967	Cytoplasmic (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CATCAGAGGAGTGCACAACCA	0.512			NA											16	19					0	0	0.004007	0	0
ELF1	1997	broad.mit.edu	37	13	41525519	41525519	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr13:41525519C>T	uc001uxs.2	-	4	680	c.307G>A	c.(307-309)GAG>AAG	p.E103K	ELF1_uc010tfc.1_Missense_Mutation_p.E103K|ELF1_uc010acd.2_5'UTR	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	103					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		AGGAGTGCCTCAGCAGCCTCA	0.368			NA											8	66					0	0	0.008291	0	0
MLNR	2862	broad.mit.edu	37	13	49795193	49795193	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr13:49795193G>A	uc010tgj.1	+	1	720	c.720G>A	c.(718-720)GCG>GCA	p.A240A		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	240	Extracellular (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		CGAGCCCCGCGCAGCTGGGCG	0.731			NA											14	28					0	0	0.003163	0	0
DIS3	22894	broad.mit.edu	37	13	73345120	73345120	+	Silent	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr13:73345120T>C	uc001vix.3	-	13	2051	c.1677A>G	c.(1675-1677)GCA>GCG	p.A559A	DIS3_uc001viy.3_Silent_p.A529A|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	559					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TACATGAAAATGCCAGCCTGT	0.318			NA								Multiple Myeloma(4;0.011)			4	6					0	0	0.000248	0	0
TPP2	7174	broad.mit.edu	37	13	103292686	103292686	+	Silent	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr13:103292686A>T	uc001vpi.3	+	16	2083	c.1980A>T	c.(1978-1980)CGA>CGT	p.R660R		NM_003291	NP_003282	P29144	TPP2_HUMAN	tripeptidyl peptidase II	660					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GTCAAATTCGAAGGCATTTTA	0.323			NA											6	12					0	0	0.004482	0	0
SOX1	6656	broad.mit.edu	37	13	112722025	112722025	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr13:112722025C>A	uc001vsb.1	+	1	113	c.53C>A	c.(52-54)GCC>GAC	p.A18D		NM_005986	NP_005977	O00570	SOX1_HUMAN	SRY (sex determining region Y)-box 1	18					chromatin organization	nucleus	core promoter sequence-specific DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0	all_lung(23;0.000652)|Lung NSC(43;0.017)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	all_cancers(25;0.000331)|Lung NSC(25;0.0496)|all_lung(25;0.0831)|all_epithelial(44;0.0868)|Breast(118;0.231)		OV - Ovarian serous cystadenocarcinoma(48;0.132)		GGCGCCCAGGCCCCCACGAAC	0.567			NA											5	4					1.23904e-05	1.84528e-05	0.000602	1	0
METT11D1	64745	broad.mit.edu	37	14	21461276	21461276	+	Splice_Site	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:21461276G>A	uc001vyn.2	+	6	726	c.529_splice	c.e6-1	p.I177_splice	METT11D1_uc001vym.2_Splice_Site_p.I177_splice|METT11D1_uc001vyo.2_Splice_Site_p.I177_splice|METT11D1_uc001vyp.2_Splice_Site_p.I19_splice|METT11D1_uc001vyq.2_Splice_Site_p.I19_splice	NM_022734	NP_073571	Q9H7H0	MET17_HUMAN	methyltransferase 11 domain containing 1 isoform						translation	mitochondrion|ribosome	copper ion binding|methyltransferase activity				0	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TATTTCTTCAGATCCGGGCTC	0.423			NA											49	66					0	0	0.00361	0	0
MYH7	4625	broad.mit.edu	37	14	23886369	23886369	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:23886369G>T	uc001wjx.2	-	32	4618	c.4512C>A	c.(4510-4512)AAC>AAA	p.N1504K		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1504	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		CACCCTGCAGGTTTTTGTTCT	0.592			NA											62	84					2.94687e-45	6.78921e-45	0.00361	1	0
FAM179B	23116	broad.mit.edu	37	14	45501514	45501514	+	Silent	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:45501514A>G	uc001wvv.2	+	11	3956	c.3747A>G	c.(3745-3747)CTA>CTG	p.L1249L	FAM179B_uc001wvw.2_Silent_p.L1249L|FAM179B_uc010anc.2_RNA	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	1249							binding			skin(2)|upper_aerodigestive_tract(1)	3						TGTCAGAACTACGACCATTCT	0.363			NA											9	12					0	0	0.006214	0	0
GPHB5	122876	broad.mit.edu	37	14	63784522	63784522	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:63784522G>A	uc010apu.2	-	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L	GPHB5_uc001xgc.2_Silent_p.L4L	NM_145171	NP_660154	Q86YW7	GPHB5_HUMAN	glycoprotein beta 5	14						extracellular region	hormone activity			breast(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00372)|all cancers(60;0.0226)|BRCA - Breast invasive adenocarcinoma(234;0.0978)		CAGCCAGAAGGAGGAGGGCCA	0.577			NA											17	24					0	0	0.00499	0	0
C14orf143	90141	broad.mit.edu	37	14	90420982	90420982	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:90420982G>C	uc001xxt.2	-	1	108	c.23C>G	c.(22-24)GCC>GGC	p.A8G	C14orf143_uc001xxs.2_5'Flank|C14orf143_uc001xxv.1_RNA|TDP1_uc010atm.2_5'Flank|TDP1_uc001xxy.2_5'Flank|TDP1_uc001xxz.2_5'Flank|TDP1_uc010atn.2_5'Flank|TDP1_uc001xya.2_5'Flank|TDP1_uc001xyb.2_5'Flank|C14orf143_uc001xxw.1_5'Flank|C14orf143_uc001xxx.1_Missense_Mutation_p.A8G	NM_145231	NP_660274	Q9BUY7	EFC11_HUMAN	hypothetical protein LOC90141	8							calcium ion binding				0		all_cancers(154;0.136)		Epithelial(152;0.194)		CCGCGACCTGGCTCTGGCCTC	0.642			NA											3	3					0	0	0.000248	0	0
KIAA1409	57578	broad.mit.edu	37	14	94066930	94066930	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:94066930C>A	uc001ybv.1	+	22	2940	c.2857C>A	c.(2857-2859)CTT>ATT	p.L953I	KIAA1409_uc001ybs.1_Missense_Mutation_p.L953I	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1130						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		ATGTCTTTGTCTTGACTTCCA	0.378			NA											16	39					1.5739e-10	2.73465e-10	0.004007	1	0
DYNC1H1	1778	broad.mit.edu	37	14	102469195	102469195	+	Silent	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr14:102469195G>C	uc001yks.2	+	23	4940	c.4776G>C	c.(4774-4776)CTG>CTC	p.L1592L		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1592	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TGGATGTTCTGAACATCCAGG	0.433			NA											5	42					0	0	0.000602	0	0
TMOD2	29767	broad.mit.edu	37	15	52065968	52065968	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr15:52065968C>T	uc002abk.2	+	4	564	c.343C>T	c.(343-345)CTT>TTT	p.L115F	TMOD2_uc002abl.3_Missense_Mutation_p.L115F|TMOD2_uc010bfb.2_Missense_Mutation_p.L71F	NM_014548	NP_055363	Q9NZR1	TMOD2_HUMAN	neuronal tropomodulin isoform a	115					nervous system development	cytoplasm|cytoskeleton	actin binding|tropomyosin binding			ovary(2)	2				all cancers(107;0.00435)		AAAAGTGACCCTTGACCCAGA	0.423			NA											35	42					0	0	0.002445	0	0
WDR72	256764	broad.mit.edu	37	15	53907848	53907849	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr15:53907848_53907849CC>AA	uc002acj.2	-	15	2596_2597	c.2554_2555GG>TT	c.(2554-2556)GGA>TTA	p.G852L	WDR72_uc010bfi.1_Missense_Mutation_p.G852L	NM_182758	NP_877435	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	852										lung(1)|skin(1)	2				all cancers(107;0.0511)		TTTTATCATTCCACTATTGCAT	0.351			NA											21	35					0	0	0.004672	0	0
RAB8B	51762	broad.mit.edu	37	15	63481946	63481946	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr15:63481946C>T	uc002alz.2	+	1	219	c.123C>T	c.(121-123)ATC>ATT	p.I41I	RAB8B_uc010uih.1_Silent_p.I41I	NM_016530	NP_057614	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	41	Effector region (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)|kidney(1)	2						TCTCCACCATCGGTGAGGGAG	0.443			NA											5	20					0	0	0.001168	0	0
NTRK3	4916	broad.mit.edu	37	15	88576139	88576139	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr15:88576139C>T	uc002bme.1	-	13	1696	c.1534G>A	c.(1534-1536)GAG>AAG	p.E512K	NTRK3_uc002bmh.2_Missense_Mutation_p.E504K|NTRK3_uc002bmf.1_Missense_Mutation_p.E512K|NTRK3_uc010upl.1_Missense_Mutation_p.E414K|NTRK3_uc010bnh.1_Missense_Mutation_p.E504K|NTRK3_uc002bmg.2_Missense_Mutation_p.E512K|NTRK3_uc010bni.2_RNA	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	512	Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGGGGGTTCTCAATGACAGGG	0.602			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			6	24					0	0	0.001984	0	0
NTRK3	4916	broad.mit.edu	37	15	88726685	88726685	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr15:88726685G>T	uc002bme.1	-	4	521	c.359C>A	c.(358-360)CCC>CAC	p.P120H	NTRK3_uc002bmh.2_Missense_Mutation_p.P120H|NTRK3_uc002bmf.1_Missense_Mutation_p.P120H|NTRK3_uc010upl.1_Missense_Mutation_p.P22H|NTRK3_uc010bnh.1_Missense_Mutation_p.P120H|NTRK3_uc002bmg.2_Missense_Mutation_p.P120H	NM_001012338	NP_001012338	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	120	LRR 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(234)	soft_tissue(85)|kidney(66)|breast(56)|salivary_gland(26)|lung(22)|large_intestine(6)|ovary(6)|stomach(5)|central_nervous_system(3)|pancreas(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	281			BRCA - Breast invasive adenocarcinoma(143;0.211)			AAAGGCTCTGGGCTGAATGCT	0.493			NA	T	ETV6	congenital fibrosarcoma|Secretory breast 					TSP Lung(13;0.10)			43	51					5.73435e-26	1.22001e-25	0.00361	1	0
PDIA2	64714	broad.mit.edu	37	16	335343	335343	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:335343T>A	uc002cgn.1	+	11	1935	c.827T>A	c.(826-828)CTC>CAC	p.L276H	PDIA2_uc010bqt.1_Missense_Mutation_p.L121H|PDIA2_uc002cgo.1_Missense_Mutation_p.L276H	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	276					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GCCAGGATCCTCAACCACCTG	0.647			NA											21	17					0	0	0.001882	0	0
C16orf11	146325	broad.mit.edu	37	16	613534	613534	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:613534C>T	uc002chk.2	+	2	519	c.240C>T	c.(238-240)TCC>TCT	p.S80S		NM_145270	NP_660313	P0CG20	CP011_HUMAN	hypothetical protein LOC146325	80										central_nervous_system(1)	1						GCCGTGGCTCCACCACGCCTA	0.687			NA											4	12					0	0	0.000248	0	0
CREBBP	1387	broad.mit.edu	37	16	3860676	3860676	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:3860676C>A	uc002cvv.2	-	3	1107	c.903G>T	c.(901-903)CAG>CAT	p.Q301H	CREBBP_uc002cvw.2_Missense_Mutation_p.Q301H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	301	Interaction with SRCAP.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGACCATGCTCTGTTTGCTGG	0.493			NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybsyndrome				43	54					1.76056e-25	3.72666e-25	0.002852	1	0
CLEC16A	23274	broad.mit.edu	37	16	11154765	11154765	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:11154765C>T	uc002dao.2	+	19	2232	c.2002C>T	c.(2002-2004)CGG>TGG	p.R668W	CLEC16A_uc002dan.3_Missense_Mutation_p.R650W	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	668										ovary(1)|central_nervous_system(1)	2						CCAGGCCATCCGGGTGTTCTT	0.532			NA											23	198					0	0	0.00333	0	0
XYLT1	64131	broad.mit.edu	37	16	17353202	17353202	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:17353202G>C	uc002dfa.2	-	3	641	c.556C>G	c.(556-558)CCG>GCG	p.P186A		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	186	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						TGTCTACTCGGTGGCTTCTTC	0.527			NA											43	62					0	0	0.002522	0	0
VWA3A	146177	broad.mit.edu	37	16	22161194	22161194	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:22161194T>C	uc010vbq.1	+	29	3167	c.3071T>C	c.(3070-3072)ATG>ACG	p.M1024T	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_Missense_Mutation_p.M102T|VWA3A_uc010bxe.1_Missense_Mutation_p.M126T	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1024	VWFA 2.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		CATGAGGCTATGCAATGGGTG	0.552			NA											19	26					0	0	0.006122	0	0
GTF3C1	2975	broad.mit.edu	37	16	27499675	27499675	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:27499675C>T	uc002dov.1	-	23	3613	c.3573G>A	c.(3571-3573)TGG>TGA	p.W1191*	GTF3C1_uc002dou.2_Nonsense_Mutation_p.W1191*	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1191						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						ACTGCTCTTCCCAGCCAGCAC	0.562			NA											6	174					0	0	0.001168	0	0
TGFB1I1	7041	broad.mit.edu	37	16	31485687	31485687	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:31485687C>G	uc002ecd.1	+	6	456	c.430C>G	c.(430-432)CCT>GCT	p.P144A	TGFB1I1_uc002ece.1_Missense_Mutation_p.P127A|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	144	Transcription activation (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						CAGCCCGTCTCCTGGCCTCCC	0.557			NA											12	64					0	0	0.001368	0	0
ABCC12	94160	broad.mit.edu	37	16	48122480	48122480	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:48122480C>T	uc002efc.1	-	24	3797	c.3451G>A	c.(3451-3453)GGG>AGG	p.G1151R	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1151	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				CCAACAATCCCGACTGTCTGC	0.463			NA											7	48					0	0	0.004482	0	0
ZNF423	23090	broad.mit.edu	37	16	49670203	49670203	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:49670203C>A	uc002efs.2	-	5	3158	c.2860G>T	c.(2860-2862)GGC>TGC	p.G954C	ZNF423_uc010vgn.1_Missense_Mutation_p.G837C	NM_015069	NP_055884	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	954					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(1)|lung(1)|kidney(1)|pancreas(1)	4		all_cancers(37;0.0155)				TTGGCAGGGCCCCGGTGCGTC	0.577			NA											17	34					0.000958276	0.00135	0.007413	1	0
CYLD	1540	broad.mit.edu	37	16	50813827	50813827	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr16:50813827C>T	uc002egp.1	+	9	1805	c.1390C>T	c.(1390-1392)CCT>TCT	p.P464S	CYLD_uc002ego.2_Missense_Mutation_p.P461S|CYLD_uc010cbs.1_Missense_Mutation_p.P461S|CYLD_uc002egq.1_Missense_Mutation_p.P461S|CYLD_uc002egr.1_Missense_Mutation_p.P461S|CYLD_uc002egs.1_Missense_Mutation_p.P461S	NM_015247	NP_056062	Q9NQC7	CYLD_HUMAN	ubiquitin carboxyl-terminal hydrolase CYLD	464	Interaction with TRAF2.|Interaction with TRIP.				cell cycle|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K63-linked deubiquitination|regulation of microtubule cytoskeleton organization|regulation of mitotic cell cycle|translation|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	cytosol|extrinsic to internal side of plasma membrane|microtubule|perinuclear region of cytoplasm|ribosome	proline-rich region binding|protein kinase binding|structural constituent of ribosome|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			skin(19)|large_intestine(3)|haematopoietic_and_lymphoid_tissue(3)|central_nervous_system(3)	28		all_cancers(37;0.0156)				GGCCATGCCTCCTGGGAACTC	0.527			NA	Mis|N|F|S		cylindroma	cylindroma			Familial_Cylindromatosis|Multiple_Trichoepithelioma_Familial				7	47					0	0	0.001984	0	0
KIAA0664	23277	broad.mit.edu	37	17	2595924	2595924	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:2595924C>A	uc002fuy.1	-	21	3348	c.3262G>T	c.(3262-3264)GCC>TCC	p.A1088S	KIAA0664_uc002fux.1_Missense_Mutation_p.A1021S|KIAA0664_uc010ckc.1_Missense_Mutation_p.A74S	NM_015229	NP_056044	O75153	K0664_HUMAN	hypothetical protein LOC23277	1088							binding			breast(2)	2						AGGTAGCGGGCGCGGTACAGC	0.706			NA											10	11					6.40141e-05	9.33353e-05	0.000978	1	0
PITPNM3	83394	broad.mit.edu	37	17	6381406	6381406	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:6381406G>A	uc002gdd.3	-	8	940	c.789C>T	c.(787-789)ATC>ATT	p.I263I	PITPNM3_uc010cln.2_Silent_p.I227I|PITPNM3_uc002gdc.3_5'UTR	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	263					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		CACAGTCCCCGATGAGACACA	0.677			NA											16	31					0	0	0.003163	0	0
C17orf68	80169	broad.mit.edu	37	17	8140817	8140817	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:8140817T>A	uc002gkq.3	-	5	727	c.668A>T	c.(667-669)CAG>CTG	p.Q223L	C17orf68_uc010cnv.2_Intron	NM_025099	NP_079375	Q2NKJ3	CTC1_HUMAN	alpha accessory factor 132	223					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding				0						CAGGTTTCGCTGCACACCTCT	0.323			NA											13	14					0	0	0.003163	0	0
MYH1	4619	broad.mit.edu	37	17	10415802	10415802	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:10415802C>G	uc002gmo.2	-	12	1164	c.1070G>C	c.(1069-1071)GGG>GCG	p.G357A	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	357	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						CATCACAGCCCCTGTGAGCTT	0.453			NA											32	38					0	0	0.002096	0	0
SYNRG	11276	broad.mit.edu	37	17	35930960	35930960	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:35930960C>T	uc002hoa.2	-	10	1206	c.1123G>A	c.(1123-1125)GAT>AAT	p.D375N	SYNRG_uc010wde.1_Missense_Mutation_p.D297N|SYNRG_uc010wdf.1_Missense_Mutation_p.D297N|SYNRG_uc002hoc.2_Missense_Mutation_p.D296N|SYNRG_uc002hoe.2_Missense_Mutation_p.D297N|SYNRG_uc002hod.2_Missense_Mutation_p.D297N|SYNRG_uc010wdg.1_Intron|SYNRG_uc002hob.2_Missense_Mutation_p.D375N|SYNRG_uc002hof.2_Missense_Mutation_p.D87N|SYNRG_uc010cvd.1_Missense_Mutation_p.D175N|SYNRG_uc002hog.1_Missense_Mutation_p.D509N	NM_007247	NP_009178	Q9UMZ2	SYNRG_HUMAN	synergin, gamma isoform 1	375	EH.				endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			ovary(2)	2						TTTAAAGCATCAGGACTCATT	0.458			NA											12	103					0	0	0.00245	0	0
KRTAP9-2	83899	broad.mit.edu	37	17	39382920	39382920	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:39382920G>T	uc002hwf.2	+	1	21	c.14G>T	c.(13-15)TGC>TTC	p.C5F		NM_031961	NP_114167	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9.2	5						keratin filament	protein binding			upper_aerodigestive_tract(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			ACCCACTGTTGCTCCCCTTGC	0.582			NA											42	120					1.35964e-18	2.68706e-18	0.00361	1	0
KRTAP9-4	85280	broad.mit.edu	37	17	39405986	39405986	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:39405986G>T	uc002hwi.2	+	1	48	c.14G>T	c.(13-15)TGC>TTC	p.C5F	KRTAP9-9_uc010wfq.1_Intron	NM_033191	NP_149461	Q9BYQ2	KRA94_HUMAN	keratin associated protein 9-4	5						keratin filament					0		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			ACCCACTGTTGCTCCCCTTGC	0.577			NA											8	92					2.27111e-07	3.52064e-07	0.001368	1	0
MRPL10	124995	broad.mit.edu	37	17	45901816	45901816	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:45901816T>C	uc002ilz.2	-	5	567	c.541A>G	c.(541-543)ATT>GTT	p.I181V	OSBPL7_uc002ilx.1_5'Flank|MRPL10_uc010wky.1_Missense_Mutation_p.I142V|MRPL10_uc002ily.2_Missense_Mutation_p.I191V	NM_145255	NP_660298	Q7Z7H8	RM10_HUMAN	mitochondrial ribosomal protein L10 precursor	181					ribosome biogenesis|translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			ovary(1)	1						GTGTCATCAATGCAGCCACCT	0.537			NA											23	16					0	0	0.00333	0	0
CA10	56934	broad.mit.edu	37	17	49731063	49731063	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:49731063G>A	uc002itw.3	-	5	1486	c.500C>T	c.(499-501)ACG>ATG	p.T167M	CA10_uc002itu.3_Missense_Mutation_p.T96M|CA10_uc002itv.3_Missense_Mutation_p.T173M|CA10_uc002itx.3_Missense_Mutation_p.T167M|CA10_uc002ity.3_Missense_Mutation_p.T167M|CA10_uc002itz.2_Missense_Mutation_p.T167M	NM_020178	NP_064563	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	167					brain development					ovary(1)|skin(1)	2			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TGTGACATTCGTATATAGCTC	0.403			NA											10	14					0	0	0.008291	0	0
INTS2	57508	broad.mit.edu	37	17	59968907	59968907	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:59968907C>A	uc002izn.2	-	14	1942	c.1866G>T	c.(1864-1866)CAG>CAT	p.Q622H	INTS2_uc002izm.2_Missense_Mutation_p.Q614H	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	622					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						TGAGTATCTCCTGTTCTGTGA	0.333			NA											41	67					6.31075e-24	1.30925e-23	0.00361	1	0
KCNJ16	3773	broad.mit.edu	37	17	68128776	68128776	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr17:68128776G>T	uc002jin.2	+	5	1034	c.548G>T	c.(547-549)CGT>CTT	p.R183L	KCNJ16_uc002jio.2_Missense_Mutation_p.R183L|KCNJ16_uc002jip.2_Missense_Mutation_p.R183L|KCNJ16_uc002jiq.2_Missense_Mutation_p.R215L	NM_018658	NP_061128	Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel J16	183	Cytoplasmic (By similarity).				synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Breast(10;2.96e-09)					CAAACCATTCGTTTCAGCTAC	0.458			NA											21	43					3.8784e-16	7.38491e-16	0.001882	1	0
ANKRD30B	374860	broad.mit.edu	37	18	14851935	14851935	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr18:14851935A>T	uc010dlo.2	+	36	3815	c.3635A>T	c.(3634-3636)CAA>CTA	p.Q1212L	ANKRD30B_uc010xal.1_Missense_Mutation_p.Q354L	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1297										ovary(1)|skin(1)	2						GCTCCTTTGCAAGGAATAATG	0.383			NA											5	4					0	0	0.000602	0	0
DSC3	1825	broad.mit.edu	37	18	28611062	28611062	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr18:28611062C>T	uc002kwj.3	-	3	386	c.231G>A	c.(229-231)GGG>GGA	p.G77G	DSC3_uc002kwi.3_Silent_p.G77G	NM_001941	NP_001932	Q14574	DSC3_HUMAN	desmocollin 3 isoform Dsc3a preproprotein	77					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			ovary(2)|skin(2)	4			OV - Ovarian serous cystadenocarcinoma(10;0.125)			TGTACACTGACCCATCATTTA	0.418			NA											7	18					0	0	0.001984	0	0
CCBE1	147372	broad.mit.edu	37	18	57122083	57122083	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr18:57122083C>A	uc002lib.2	-	6	724	c.654G>T	c.(652-654)AAG>AAT	p.K218N	CCBE1_uc010dpq.2_5'UTR|CCBE1_uc002lia.2_Missense_Mutation_p.K71N	NM_133459	NP_597716	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	218					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			skin(2)|ovary(1)	3		Colorectal(73;0.175)				CGGCACGTACCTTTTGCTTCA	0.507	NSCLC(137;1340 1860 15773 39604 51087)|Esophageal Squamous(139;339 1777 2926 19691 38524)		NA											22	23					1.50039e-11	2.68525e-11	0.001882	1	0
C19orf29	58509	broad.mit.edu	37	19	3611989	3611989	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:3611989G>A	uc002lyh.2	-	10	2262	c.2209C>T	c.(2209-2211)CGC>TGC	p.R737C	C19orf29_uc010xho.1_Missense_Mutation_p.R196C|C19orf29_uc010dtn.2_Missense_Mutation_p.R585C|C19orf29_uc002lyi.3_Missense_Mutation_p.R737C|C19orf29_uc010dto.2_RNA	NM_001080543	NP_001074012	Q8WUQ7	CS029_HUMAN	chromosome 19 open reading frame 29	737						catalytic step 2 spliceosome	protein binding				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		AACTGGCAGCGGAAGCCGTGG	0.632			NA											5	55					0	0	0.000602	0	0
C3	718	broad.mit.edu	37	19	6696469	6696469	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:6696469C>A	uc002mfm.2	-	23	2933	c.2871G>T	c.(2869-2871)GTG>GTT	p.V957V		NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	957					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCTCTTTCTGCACTCCTTCTG	0.572			NA											13	16					1.5842e-08	2.56051e-08	0.001855	1	0
FBN3	84467	broad.mit.edu	37	19	8196582	8196582	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:8196582C>A	uc002mjf.2	-	14	1867	c.1846G>T	c.(1846-1848)GTG>TTG	p.V616L		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	616						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						GTGCTGCGCACGTGGGTGTCC	0.677			NA											10	19					0.000673444	0.000951953	0.008291	1	0
FBXL12	54850	broad.mit.edu	37	19	9921644	9921644	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:9921644C>A	uc002mme.2	-	3	1151	c.909G>T	c.(907-909)CTG>CTT	p.L303L	FBXL12_uc002mmd.2_Silent_p.L250L|FBXL12_uc002mmf.2_Silent_p.L250L|FBXL12_uc002mmg.2_Silent_p.L250L|FBXL12_uc002mmh.2_Silent_p.L250L	NM_017703	NP_060173	Q9NXK8	FXL12_HUMAN	F-box and leucine-rich repeat protein 12	303							protein binding			lung(1)|kidney(1)	2						GCCCCTTACACAGGATCTTCT	0.597			NA											16	14					1.99824e-07	3.12084e-07	0.00499	1	0
COL5A3	50509	broad.mit.edu	37	19	10107298	10107298	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:10107298A>G	uc002mmq.1	-	12	1417	c.1331T>C	c.(1330-1332)ATG>ACG	p.M444T		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	444	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			TACCGGCATCATGATCACAGT	0.532			NA											19	33					0	0	0.007413	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10224379	10224379	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:10224379C>T	uc002mna.2	+	13	1350	c.1350C>T	c.(1348-1350)TTC>TTT	p.F450F	PPAN-P2RY11_uc010xla.1_Missense_Mutation_p.S471F|P2RY11_uc002mnc.2_Silent_p.F30F	NM_001040664	NP_001035754	Q9NQ55	SSF1_HUMAN	PPAN-P2RY11 protein	Error:Variant_position_missing_in_Q9NQ55_after_alignment					RNA splicing	nucleolus	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			AGGGGGACTTCCTGTGGCCCA	0.637			NA									OREG0025230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	18					0	0	0.007413	0	0
KEAP1	9817	broad.mit.edu	37	19	10600474	10600474	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:10600474T>C	uc002moq.1	-	4	1537	c.1381A>G	c.(1381-1383)ATC>GTC	p.I461V	KEAP1_uc002mop.1_Missense_Mutation_p.I179V|KEAP1_uc002mor.1_Missense_Mutation_p.I461V	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	461	Kelch 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CCCACCCCGATCCTTCGTGTC	0.552			NA											12	15					0	0	0.001368	0	0
ZNF700	90592	broad.mit.edu	37	19	12061049	12061049	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:12061049G>A	uc002msu.2	+	4	2336	c.2210G>A	c.(2209-2211)TGT>TAT	p.C737Y	ZNF700_uc010xme.1_Missense_Mutation_p.C755Y|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGTAAGGATTGTGGGAAAGCA	0.398			NA											11	19					0	0	0.001855	0	0
ZNF44	51710	broad.mit.edu	37	19	12383799	12383799	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:12383799T>C	uc010xmj.1	-	5	1620	c.1415A>G	c.(1414-1416)AAG>AGG	p.K472R	ZNF44_uc002mtl.2_Intron|ZNF44_uc010dyr.1_Intron|ZNF44_uc010xmi.1_RNA|ZNF44_uc002mtn.3_RNA|ZNF44_uc010dys.2_Missense_Mutation_p.K424R	NM_001164276	NP_001157748	P15621	ZNF44_HUMAN	zinc finger protein 44 isoform 1	472	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		CCCACATTGCTTGCATTCATA	0.423			NA											27	32					0	0	0.00632	0	0
NCAN	1463	broad.mit.edu	37	19	19356128	19356128	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:19356128G>A	uc002nlz.2	+	13	3598	c.3499G>A	c.(3499-3501)GAG>AAG	p.E1167K	NCAN_uc002nma.2_Intron	NM_004386	NP_004377	O14594	NCAN_HUMAN	chondroitin sulfate proteoglycan 3 precursor	1167	C-type lectin.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(4)	4			Epithelial(12;0.00544)			GCAGCAATTTGAGAACTGGCG	0.607			NA											17	18					0	0	0.006122	0	0
ZNF257	113835	broad.mit.edu	37	19	22271945	22271945	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:22271945G>T	uc010ecx.2	+	4	1562	c.1393G>T	c.(1393-1395)GGC>TGC	p.G465C	ZNF257_uc010ecy.2_Missense_Mutation_p.G433C	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	465	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				TGAAGAGTGTGGCAAAGCCTT	0.403			NA											11	27					4.68919e-08	7.43495e-08	0.008291	1	0
ZNF99	7652	broad.mit.edu	37	19	22952782	22952782	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:22952782C>G	uc010xrh.1	-	1	3	c.3G>C	c.(1-3)ATG>ATC	p.M1I		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACCAAAAAGACATGTTGAGTT	0.159			NA											7	16					0	0	0.00308	0	0
KCNK6	9424	broad.mit.edu	37	19	38817582	38817582	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:38817582G>T	uc002oic.2	+	2	782	c.672G>T	c.(670-672)GAG>GAT	p.E224D	KCNK6_uc002oid.2_Missense_Mutation_p.E90D	NM_004823	NP_004814	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	224						voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(1)	1	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	TGCCCGGGGAGGCCCCTGGCC	0.637			NA											43	58					1.02591e-13	1.89293e-13	0.002522	1	0
AKT2	208	broad.mit.edu	37	19	40748459	40748459	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:40748459G>A	uc002onf.2	-	5	685	c.423C>T	c.(421-423)AGC>AGT	p.S141S	AKT2_uc010egs.2_Silent_p.S141S|AKT2_uc010egt.2_Silent_p.S79S|AKT2_uc010xvj.1_Silent_p.S79S|AKT2_uc010egu.1_Silent_p.S79S|AKT2_uc010xvk.1_Silent_p.S141S|AKT2_uc002one.2_Silent_p.S37S	NM_001626	NP_001617	P31751	AKT2_HUMAN	AKT2 kinase	141					insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)	2			Lung(22;0.000499)			CCCGTGCCTTGCTGACCGCCA	0.647			NA	A		ovarian|pancreatic 								56	73					0	0	0.00361	0	0
PLD3	23646	broad.mit.edu	37	19	40884020	40884020	+	Silent	SNP	T	T	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:40884020T>G	uc002onm.3	+	13	1811	c.1413T>G	c.(1411-1413)CCT>CCG	p.P471P	PLD3_uc002onj.3_Silent_p.P471P|PLD3_uc002onk.3_Silent_p.P471P|PLD3_uc002onl.3_Silent_p.P471P|PLD3_uc002onn.2_Silent_p.P471P	NM_001031696	NP_001026866	Q8IV08	PLD3_HUMAN	phospholipase D3	471	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			skin(2)|ovary(1)	3			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			GGGACTCCCCTTACAGCCATG	0.682			NA											58	68					0	0	0.00361	0	0
ZNF480	147657	broad.mit.edu	37	19	52825717	52825717	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:52825717G>T	uc010ydl.1	+	5	1284	c.1214G>T	c.(1213-1215)GGA>GTA	p.G405V	ZNF480_uc002pyv.2_Missense_Mutation_p.G328V|ZNF480_uc010ydm.1_Missense_Mutation_p.G362V|ZNF480_uc010epn.2_Missense_Mutation_p.G236V|uc002pyw.1_Intron	NM_144684	NP_653285	Q8WV37	ZN480_HUMAN	zinc finger protein 480	405	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		AATGAATGTGGAAAAGTATTT	0.338			NA											15	55					6.31663e-08	9.93975e-08	0.003163	1	0
ZNF813	126017	broad.mit.edu	37	19	53989948	53989948	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:53989948C>G	uc002qbu.2	+	3	206	c.78C>G	c.(76-78)GAC>GAG	p.D26E	ZNF813_uc010eqq.1_RNA	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		AATGCCTGGACCCTGCTCAGA	0.478			NA											46	95					0	0	0.00361	0	0
NLRP12	91662	broad.mit.edu	37	19	54299200	54299200	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:54299200T>A	uc002qch.3	-	9	3231	c.3011A>T	c.(3010-3012)TAC>TTC	p.Y1004F	NLRP12_uc010eqw.2_Missense_Mutation_p.Y230F|NLRP12_uc002qci.3_Missense_Mutation_p.Y947F|NLRP12_uc002qcj.3_Missense_Mutation_p.Y1005F|NLRP12_uc002qck.3_RNA|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	1004	LRR 7.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		GTTGGTCAGGTAAAGGTCGGT	0.557			NA											20	19					0	0	0.008871	0	0
NLRP4	147945	broad.mit.edu	37	19	56373374	56373374	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr19:56373374T>G	uc002qmd.3	+	5	2457	c.2035T>G	c.(2035-2037)TTT>GTT	p.F679V	NLRP4_uc002qmf.2_Missense_Mutation_p.F604V|NLRP4_uc010etf.2_Missense_Mutation_p.F510V	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	679							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TAACGTTTCCTTTTCTGGCCA	0.428			NA											23	45					0	0	0.003954	0	0
MTA3	57504	broad.mit.edu	37	2	42909573	42909573	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:42909573C>T	uc002rso.1	+	10	1237	c.567C>T	c.(565-567)AGC>AGT	p.S189S	MTA3_uc002rsp.1_Silent_p.S189S|MTA3_uc002rsq.2_Silent_p.S245S|MTA3_uc002rsr.2_Silent_p.S245S	NM_020744	NP_065795	Q9BTC8	MTA3_HUMAN	metastasis associated 1 family, member 3	245	ELM2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2						ATAGACACAGCTATGATTTGA	0.373			NA											5	10					0	0	0.000602	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73316265	73316265	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:73316265C>T	uc002siu.3	-	2	851	c.610G>A	c.(610-612)GAT>AAT	p.D204N	RAB11FIP5_uc002sit.3_Missense_Mutation_p.D126N	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	204					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GATTCCAGATCATACTTCTTC	0.542			NA											20	118					0	0	0.008871	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73316441	73316441	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:73316441C>T	uc002siu.3	-	2	675	c.434G>A	c.(433-435)TGG>TAG	p.W145*	RAB11FIP5_uc002sit.3_Nonsense_Mutation_p.W67*	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	145					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						CAGCTTGTACCACCTGTGAGA	0.607			NA											27	150					0	0	0.004656	0	0
REG3G	130120	broad.mit.edu	37	2	79253884	79253884	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:79253884C>G	uc002snw.2	+	3	207	c.122C>G	c.(121-123)CCC>CGC	p.P41R	REG3G_uc002snx.2_Missense_Mutation_p.P41R|REG3G_uc010ffu.2_Missense_Mutation_p.P41R	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	41					acute-phase response	extracellular region	sugar binding				0						ATCAGCTGTCCCAAAGGCTCC	0.532			NA											30	15					0	0	0.007291	0	0
REG3G	130120	broad.mit.edu	37	2	79253909	79253909	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:79253909C>A	uc002snw.2	+	3	232	c.147C>A	c.(145-147)TCC>TCA	p.S49S	REG3G_uc002snx.2_Silent_p.S49S|REG3G_uc010ffu.2_Silent_p.S49S	NM_198448	NP_940850	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma precursor	49	C-type lectin.				acute-phase response	extracellular region	sugar binding				0						CCTATGGCTCCCCCTGCTATG	0.522			NA											15	32					2.32078e-09	3.93401e-09	0.003163	1	0
CKAP2L	150468	broad.mit.edu	37	2	113513884	113513884	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:113513884T>G	uc002tie.2	-	4	1143	c.1064A>C	c.(1063-1065)CAG>CCG	p.Q355P	CKAP2L_uc002tif.2_Intron|CKAP2L_uc010yxp.1_Missense_Mutation_p.Q190P|CKAP2L_uc010yxq.1_Missense_Mutation_p.Q190P	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	355						centrosome					0						GCTGGACTTCTGATCTTGCTT	0.423			NA											8	92					0	0	0.00308	0	0
ITGB6	3694	broad.mit.edu	37	2	161029180	161029180	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:161029180G>C	uc002ubh.2	-	6	837	c.821C>G	c.(820-822)TCT>TGT	p.S274C	ITGB6_uc010fow.1_RNA|ITGB6_uc010fou.2_Missense_Mutation_p.S274C|ITGB6_uc010zcq.1_Missense_Mutation_p.S232C|ITGB6_uc010fov.1_Missense_Mutation_p.S274C	NM_000888	NP_000879	P18564	ITB6_HUMAN	integrin, beta 6 precursor	274	Extracellular (Potential).|VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			ovary(1)|lung(1)|skin(1)	3						TCCAAAATGAGAATCAGCATC	0.453			NA											10	100					0	0	0.001855	0	0
SCN3A	6328	broad.mit.edu	37	2	165947810	165947810	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:165947810G>T	uc002ucx.2	-	28	5345	c.4853C>A	c.(4852-4854)ACC>AAC	p.T1618N	SCN3A_uc010zcy.1_Missense_Mutation_p.T101N|SCN3A_uc002ucy.2_Missense_Mutation_p.T1569N|SCN3A_uc002ucz.2_Missense_Mutation_p.T1569N	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1618						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TCGGAACAAGGTAGGGGACAC	0.443			NA											38	53					3.54561e-26	7.62122e-26	0.002222	1	0
RBM45	129831	broad.mit.edu	37	2	178985109	178985109	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:178985109G>A	uc002ulv.2	+	4	738	c.646G>A	c.(646-648)GAA>AAA	p.E216K		NM_152945	NP_694453	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	216					cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			TTTGGGACATGAACCTAGAGT	0.318			NA											7	26					0	0	0.001984	0	0
TTN	7273	broad.mit.edu	37	2	179414882	179414882	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:179414882G>C	uc010zfg.1	-	286	84203	c.83979C>G	c.(83977-83979)TTC>TTG	p.F27993L	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.F21688L|TTN_uc010zfi.1_Missense_Mutation_p.F21621L|TTN_uc010zfj.1_Missense_Mutation_p.F21496L	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	28920							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCATCTTTGAACCAAGTTA	0.438			NA											21	141					0	0	0.004656	0	0
TTN	7273	broad.mit.edu	37	2	179580343	179580343	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:179580343A>T	uc010zfg.1	-	86	22290	c.22066T>A	c.(22066-22068)TTC>ATC	p.F7356I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.F4017I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8283							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGTCAACGAATGACATTCTG	0.463			NA											15	18					0	0	0.004007	0	0
C2orf67	151050	broad.mit.edu	37	2	211018910	211018910	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:211018910T>A	uc002vds.2	-	2	605	c.397A>T	c.(397-399)ATC>TTC	p.I133F	C2orf67_uc002vdt.2_Missense_Mutation_p.I133F|C2orf67_uc002vdw.2_Missense_Mutation_p.I133F|C2orf67_uc002vdy.1_Missense_Mutation_p.I133F|C2orf67_uc002vdv.2_Missense_Mutation_p.I133F|C2orf67_uc002vdx.1_Missense_Mutation_p.I133F	NM_152519	NP_689732	A0AUZ9	CB067_HUMAN	hypothetical protein LOC151050	133										ovary(3)	3		Renal(323;0.202)		Epithelial(149;0.00435)|Lung(261;0.0529)|LUSC - Lung squamous cell carcinoma(261;0.0551)|all cancers(144;0.0696)		TCCTTTTTGATGAACTCTTCA	0.368			NA											19	24					0	0	0.007413	0	0
CPS1	1373	broad.mit.edu	37	2	211441117	211441117	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:211441117C>A	uc002vee.3	+	3	416	c.284C>A	c.(283-285)ACA>AAA	p.T95K	CPS1_uc010fur.2_Missense_Mutation_p.T101K	NM_001875	NP_001866	P31327	CPSM_HUMAN	carbamoyl-phosphate synthetase 1 isoform b	95	Anthranilate phosphoribosyltransferase homolog.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			ovary(8)|central_nervous_system(3)|breast(1)|skin(1)	13				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CAGATTCTCACAATGGCCAAC	0.413			NA											31	45					3.99451e-17	7.71162e-17	0.001786	1	0
DGKD	8527	broad.mit.edu	37	2	234372909	234372909	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:234372909G>T	uc002vui.1	+	27	3298	c.3286G>T	c.(3286-3288)GCA>TCA	p.A1096S	DGKD_uc002vuj.1_Missense_Mutation_p.A1052S|DGKD_uc010fyi.1_RNA	NM_152879	NP_690618	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa isoform 2	1096					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|pancreas(1)|lung(1)|skin(1)	5		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CTGCCAGTCCGCAGAGCCCGG	0.647			NA											20	22					4.35082e-09	7.25716e-09	0.001523	1	0
KIF1A	547	broad.mit.edu	37	2	241679756	241679756	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:241679756G>A	uc002vzy.2	-	34	3618	c.3472C>T	c.(3472-3474)CGT>TGT	p.R1158C	KIF1A_uc010fzk.2_Missense_Mutation_p.R1259C|KIF1A_uc002vzz.1_Missense_Mutation_p.R1259C	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1158					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		ATGCCCCCACGGTGGTCCACC	0.662			NA											4	38					0	0	0.001168	0	0
DDRGK1	65992	broad.mit.edu	37	20	3175885	3175885	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:3175885C>T	uc002wic.2	-	5	647	c.625G>A	c.(625-627)GAG>AAG	p.E209K	DDRGK1_uc010gaw.2_RNA|DDRGK1_uc010gax.1_Missense_Mutation_p.E209K	NM_023935	NP_076424	Q96HY6	DDRGK_HUMAN	DDRGK domain containing 1 precursor	209						endoplasmic reticulum	protein binding				0						ACCTGTTCCTCAGTCATGGTC	0.642			NA											11	71					0	0	0.001855	0	0
DDRGK1	65992	broad.mit.edu	37	20	3175889	3175889	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:3175889C>T	uc002wic.2	-	5	643	c.621G>A	c.(619-621)ATG>ATA	p.M207I	DDRGK1_uc010gaw.2_RNA|DDRGK1_uc010gax.1_Missense_Mutation_p.M207I	NM_023935	NP_076424	Q96HY6	DDRGK_HUMAN	DDRGK domain containing 1 precursor	207						endoplasmic reticulum	protein binding				0						GTTCCTCAGTCATGGTCTCTC	0.637			NA											12	70					0	0	0.001855	0	0
DDRGK1	65992	broad.mit.edu	37	20	3175940	3175940	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:3175940C>T	uc002wic.2	-	5	592	c.570G>A	c.(568-570)CTG>CTA	p.L190L	DDRGK1_uc010gaw.2_RNA|DDRGK1_uc010gax.1_Silent_p.L190L	NM_023935	NP_076424	Q96HY6	DDRGK_HUMAN	DDRGK domain containing 1 precursor	190						endoplasmic reticulum	protein binding				0						CCTTCAGTTTCAGGTACTCCT	0.617			NA											9	58					0	0	0.004482	0	0
SLC4A11	83959	broad.mit.edu	37	20	3210254	3210254	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:3210254G>C	uc002wig.2	-	13	1754	c.1706C>G	c.(1705-1707)TCA>TGA	p.S569*	SLC4A11_uc010zqe.1_Nonsense_Mutation_p.S596*|SLC4A11_uc002wih.2_RNA|SLC4A11_uc010zqf.1_Nonsense_Mutation_p.S553*	NM_032034	NP_114423	Q8NBS3	S4A11_HUMAN	solute carrier family 4 member 11	569	Extracellular (Potential).|Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			ovary(1)	1						CGCCTGGCCTGAGTGTGTGGC	0.667	NSCLC(190;922 2139 10266 10292 38692)		NA											11	19					0	0	0.000978	0	0
PLCB1	23236	broad.mit.edu	37	20	8689341	8689341	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:8689341T>A	uc002wnb.2	+	12	1195	c.1192T>A	c.(1192-1194)TGT>AGT	p.C398S	PLCB1_uc010zrb.1_Missense_Mutation_p.C297S|PLCB1_uc002wna.2_Missense_Mutation_p.C398S|PLCB1_uc002wnc.1_Missense_Mutation_p.C297S	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	398	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						AATTGCGGAGTGTGCATTTAA	0.343			NA											8	18					0	0	0.004482	0	0
KIAA1755	85449	broad.mit.edu	37	20	36841670	36841670	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:36841670G>T	uc002xhy.1	-	14	3649	c.3377C>A	c.(3376-3378)CCA>CAA	p.P1126Q	KIAA1755_uc002xhv.1_Missense_Mutation_p.P190Q|KIAA1755_uc002xhw.1_Missense_Mutation_p.P181Q|KIAA1755_uc002xhx.1_Missense_Mutation_p.P404Q	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	1126										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TTCCTGGGGTGGAGAGCCTGC	0.607			NA											6	17					3.59834e-05	5.30214e-05	0.001168	1	0
TOX2	84969	broad.mit.edu	37	20	42694462	42694462	+	Silent	SNP	G	G	T	rs148482710		TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:42694462G>T	uc002xlf.3	+	6	1034	c.1017G>T	c.(1015-1017)ACG>ACT	p.T339T	TOX2_uc010ggo.2_Silent_p.T357T|TOX2_uc002xle.3_Silent_p.T315T|TOX2_uc010ggp.2_Silent_p.T315T|TOX2_uc002xlg.2_Intron|TOX2_uc010zwk.1_Silent_p.T235T	NM_001098798	NP_001092268	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	339					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCTTCCTGACGCCGTCGGACC	0.662			NA											25	53					9.86323e-18	1.91301e-17	0.003954	1	0
C20orf43	51507	broad.mit.edu	37	20	55092258	55092258	+	Splice_Site	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:55092258G>T	uc002xxt.2	+	8	849	c.742_splice	c.e8+1	p.A248_splice	C20orf43_uc010zzf.1_Splice_Site_p.A278_splice|C20orf43_uc002xxu.2_Splice_Site_p.A247_splice|C20orf43_uc002xxv.2_Splice_Site_p.Q229_splice|GCNT7_uc010zzg.1_Intron	NM_016407	NP_057491	Q9BY42	CT043_HUMAN	hypothetical protein LOC51507											ovary(1)	1			Colorectal(105;0.202)			AAAAGCACAGGTGGGTCCTGT	0.542			NA											5	9					0.000602214	0.000854161	0.000602	1	0
VAPB	9217	broad.mit.edu	37	20	57016113	57016113	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:57016113C>T	uc002xza.2	+	5	818	c.547C>T	c.(547-549)CTA>TTA	p.L183L	VAPB_uc002xzb.2_RNA|VAPB_uc010zzo.1_Silent_p.L60L|VAPB_uc002xzc.2_Intron	NM_004738	NP_004729	O95292	VAPB_HUMAN	VAMP-associated protein B/C	183	Potential.|Cytoplasmic (Potential).				cell death|endoplasmic reticulum unfolded protein response|positive regulation of viral genome replication|sphingolipid metabolic process|virus-host interaction	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	beta-tubulin binding|enzyme binding|protein heterodimerization activity|protein homodimerization activity|structural molecule activity			kidney(1)	1	Lung NSC(12;0.000615)|all_lung(29;0.00186)		BRCA - Breast invasive adenocarcinoma(13;6.2e-12)|Epithelial(14;3.7e-08)|all cancers(14;3.88e-07)			AGTTCAGAGGCTACGGGAGGA	0.423			NA											3	9					0	0	0.004672	0	0
PHACTR3	116154	broad.mit.edu	37	20	58348444	58348444	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:58348444C>A	uc002yau.2	+	6	1329	c.862C>A	c.(862-864)CTT>ATT	p.L288I	PHACTR3_uc002yat.2_Missense_Mutation_p.L285I|PHACTR3_uc010zzw.1_Missense_Mutation_p.L247I|PHACTR3_uc002yav.2_Missense_Mutation_p.L247I|PHACTR3_uc002yaw.2_Missense_Mutation_p.L247I|PHACTR3_uc002yax.2_Missense_Mutation_p.L177I	NM_080672	NP_542403	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3 isoform 1	288						nuclear matrix	actin binding|protein phosphatase inhibitor activity			ovary(2)|pancreas(1)	3	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CCACCGGCCTCTTCCCCCAAG	0.672			NA											20	18					4.96729e-08	7.84606e-08	0.008871	1	0
TIAM1	7074	broad.mit.edu	37	21	32508251	32508251	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr21:32508251C>A	uc002yow.1	-	24	4355	c.3883G>T	c.(3883-3885)GTC>TTC	p.V1295F	TIAM1_uc011adk.1_Missense_Mutation_p.V1295F|TIAM1_uc011adl.1_Missense_Mutation_p.V1235F	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1295	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TGATACACACCGAATGCTGCC	0.448			NA											22	26					1.87028e-06	2.84638e-06	0.001882	1	0
TIAM1	7074	broad.mit.edu	37	21	32638875	32638875	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr21:32638875G>A	uc002yow.1	-	5	886	c.414C>T	c.(412-414)GAC>GAT	p.D138D	TIAM1_uc011adk.1_Silent_p.D138D|TIAM1_uc011adl.1_Silent_p.D138D|TIAM1_uc002yox.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	138					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						AATATGTAGCGTCATCCCCGT	0.537			NA											21	43					0	0	0.008871	0	0
SLC25A18	83733	broad.mit.edu	37	22	18065397	18065397	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr22:18065397C>G	uc002zmp.1	+	6	762	c.268C>G	c.(268-270)CGG>GGG	p.R90G	SLC25A18_uc010gqx.2_Missense_Mutation_p.R90G|SLC25A18_uc002zmq.1_Missense_Mutation_p.R90G	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	90	Solcar 1.					integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)	CGACTTTTTCCGGCGGCTGCT	0.542	Colon(118;1560 1625 18964 29606 50093)		NA											5	2					0	0	0.001168	0	0
ZNF74	7625	broad.mit.edu	37	22	20755021	20755021	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr22:20755021G>C	uc010gsm.2	+	4	432	c.220G>C	c.(220-222)GAG>CAG	p.E74Q	ZNF74_uc002zsg.2_Missense_Mutation_p.E3Q|ZNF74_uc002zsh.2_Missense_Mutation_p.E74Q|ZNF74_uc002zsi.2_Missense_Mutation_p.E3Q|ZNF74_uc010gsn.2_Missense_Mutation_p.E3Q	NM_003426	NP_003417	Q16587	ZNF74_HUMAN	zinc finger protein 74	74	KRAB.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			ovary(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TGTGATGTTGGAGAACTACCA	0.542			NA											15	79					0	0	0.00245	0	0
MMP11	4320	broad.mit.edu	37	22	24122785	24122785	+	Missense_Mutation	SNP	G	G	T	rs142391582	by1000genomes	TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr22:24122785G>T	uc002zxx.2	+	4	521	c.499G>T	c.(499-501)GAC>TAC	p.D167Y	MMP11_uc002zxy.2_RNA|MMP11_uc002zxz.2_5'Flank	NM_005940	NP_005931	P24347	MMP11_HUMAN	matrix metalloproteinase 11 preproprotein	167					collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|large_intestine(1)	3		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				GCATGGGGACGACCTGCCGTT	0.647			NA											7	22					8.12818e-05	0.000117282	0.001984	1	0
PVALB	5816	broad.mit.edu	37	22	37209698	37209698	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr22:37209698C>A	uc010gwz.2	-	3	326	c.296G>T	c.(295-297)GGG>GTG	p.G99V	PVALB_uc003apx.2_Missense_Mutation_p.G99V	NM_002854	NP_002845	P20472	PRVA_HUMAN	parvalbumin	99	EF-hand 2.|2.			Missing (in Ref. 1; CAA45134).			calcium ion binding			skin(1)	1						ACCGTCAACCCCAATTTTGCC	0.512			NA											52	83					1.63038e-21	3.31643e-21	0.00361	1	0
LGALS2	3957	broad.mit.edu	37	22	37966365	37966365	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr22:37966365C>A	uc003ata.2	-	4	416	c.304G>T	c.(304-306)GAG>TAG	p.E102*		NM_006498	NP_006489	P05162	LEG2_HUMAN	lectin, galactoside-binding, soluble, 2	102	Galectin.									breast(1)|skin(1)	2	Melanoma(58;0.0574)					AAAGTCAGCTCGTGCCCATCT	0.527	GBM(193;1840 2185 13711 20676 24505)		NA											7	55					8.12818e-05	0.000117282	0.001984	1	0
TCF20	6942	broad.mit.edu	37	22	42608404	42608404	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr22:42608404C>A	uc003bcj.1	-	1	3042	c.2908G>T	c.(2908-2910)GCA>TCA	p.A970S	TCF20_uc003bck.1_Missense_Mutation_p.A970S|TCF20_uc003bnt.2_Missense_Mutation_p.A970S	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	970					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						TCATGGGTTGCTGCTCCAGGG	0.562			NA											27	44					7.26314e-15	1.3767e-14	0.007291	1	0
CHL1	10752	broad.mit.edu	37	3	432804	432804	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:432804C>T	uc003bou.2	+	21	2976	c.2705C>T	c.(2704-2706)CCT>CTT	p.P902L	CHL1_uc003bot.2_Missense_Mutation_p.P918L|CHL1_uc003bow.1_Missense_Mutation_p.P902L|CHL1_uc011asi.1_Missense_Mutation_p.P918L	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	902	Fibronectin type-III 3.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GGAGCTGGTCCTGAAAGTGAG	0.383			NA											19	27					0	0	0.008871	0	0
CNTN4	152330	broad.mit.edu	37	3	2861215	2861215	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:2861215G>T	uc003bpc.2	+	6	625	c.404G>T	c.(403-405)CGT>CTT	p.R135L	CNTN4_uc003bpb.1_5'UTR|CNTN4_uc003bpd.1_Missense_Mutation_p.R135L	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	135	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		GTGTCTGTCCGTCGAGGTCAA	0.403			NA											19	30					1.55795e-14	2.92641e-14	0.001882	1	0
EDEM1	9695	broad.mit.edu	37	3	5244822	5244822	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:5244822A>G	uc003bqi.2	+	5	1162	c.1030A>G	c.(1030-1032)ACA>GCA	p.T344A	EDEM1_uc011asz.1_Missense_Mutation_p.T122A|EDEM1_uc003bqh.2_Missense_Mutation_p.T344A	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	344	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		GAGCAATGATACAGGATTACT	0.537			NA											38	55					0	0	0.004878	0	0
DCLK3	85443	broad.mit.edu	37	3	36779795	36779795	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:36779795G>T	uc003cgi.2	-	2	847	c.356C>A	c.(355-357)GCA>GAA	p.A119E		NM_033403	NP_208382	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	119						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			lung(3)|large_intestine(2)|breast(1)|skin(1)|ovary(1)|kidney(1)	9						CTCTCCCCTTGCGTGCCTCTC	0.572			NA											66	96					1.74474e-33	3.93275e-33	0.00361	1	0
CTNNB1	1499	broad.mit.edu	37	3	41266113	41266113	+	Missense_Mutation	SNP	C	C	T	rs121913403		TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:41266113C>T	uc010hia.1	+	4	266	c.110C>T	c.(109-111)TCT>TTT	p.S37F	CTNNB1_uc003ckp.2_Missense_Mutation_p.S37F|CTNNB1_uc003ckq.2_Missense_Mutation_p.S37F|CTNNB1_uc003ckr.2_Missense_Mutation_p.S37F|CTNNB1_uc011azf.1_Missense_Mutation_p.S30F|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	37			S -> C (in PTR, hepatoblastoma and ovarian cancer).|SG -> W (in hepatocellular carcinoma).|S -> F (in PTR).|S -> A (in MDB and hepatocellular carcinoma; enhances transactivation of target genes).|S -> Y (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S37F(147)|p.S37C(124)|p.A5_A80del(63)|p.S37A(59)|p.S37Y(23)|p.S37P(16)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.V22_G80>NNNNN(1)|p.GIHS34?(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.V22_T102del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.P16_K133del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.G34_S37del(1)|p.I35_S37>T(1)|p.I35_K170del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.S37S(1)|p.S37T(1)|p.V22_S71>A(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.V22_Y64del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.Y30_T40del(1)|p.M1_T42del(1)|p.S37_G38>W(1)|p.A5_Q143>E(1)|p.I35_G38del(1)|p.H36_E53>L(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.S37_A39>S(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.I35_T41del(1)|p.W25_A80del(1)|p.A20_Q72del(1)|p.A20_S111del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGAATCCATTCTGGTGCCACT	0.498	Colon(6;3 56 14213 18255)	S37F(HUTU80_SMALL_INTESTINE)|S37C(SNU398_LIVER)|S37C(JHUEM2_ENDOMETRIUM)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				14	19					0	0	0.001855	0	0
ZNF35	7584	broad.mit.edu	37	3	44700297	44700297	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:44700297C>T	uc003cnq.2	+	4	663	c.442C>T	c.(442-444)CAA>TAA	p.Q148*	ZNF35_uc003cnr.2_5'UTR	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	148	Globular domain.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		AGCTGATCCTCAAGGACCTGA	0.388			NA											6	47					0	0	0.00308	0	0
ZNF501	115560	broad.mit.edu	37	3	44775979	44775979	+	Silent	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:44775979A>G	uc003cnu.1	+	3	467	c.66A>G	c.(64-66)TCA>TCG	p.S22S	ZNF501_uc003cnv.1_Silent_p.S22S	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	22	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		AGAAACCTTCAAAGTGTAGTG	0.413			NA											15	16					0	0	0.008871	0	0
ALS2CL	259173	broad.mit.edu	37	3	46717892	46717892	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:46717892C>A	uc003cqa.1	-	19	2219	c.2029G>T	c.(2029-2031)GCT>TCT	p.A677S	ALS2CL_uc003cpx.1_Missense_Mutation_p.A24S|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Missense_Mutation_p.A192S|ALS2CL_uc003cqb.1_Missense_Mutation_p.A677S|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	677					endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		TTGCTCAGAGCCTGGGCCAGT	0.592			NA											14	25					2.31682e-05	3.43813e-05	0.003163	1	0
CCDC51	79714	broad.mit.edu	37	3	48474184	48474184	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:48474184C>T	uc003csz.2	-	4	991	c.870G>A	c.(868-870)CCG>CCA	p.P290P	PLXNB1_uc003csx.2_5'Flank|CCDC51_uc003cta.2_Silent_p.P181P|CCDC51_uc003ctb.2_Silent_p.P181P|CCDC51_uc003ctc.2_Silent_p.P290P|CCDC51_uc003ctd.2_Silent_p.P181P	NM_024661	NP_078937	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	290						integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		TGTCTCTGGTCGGGGGACTAC	0.562			NA											21	57					0	0	0.001882	0	0
P4HTM	54681	broad.mit.edu	37	3	49043295	49043295	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:49043295G>A	uc003cvg.2	+	7	1508	c.1159G>A	c.(1159-1161)GAA>AAA	p.E387K	P4HTM_uc003cvh.2_Missense_Mutation_p.E448K|WDR6_uc011bbx.1_5'Flank|WDR6_uc003cvj.2_5'Flank|WDR6_uc011bby.1_5'Flank|WDR6_uc010hkn.2_5'Flank|WDR6_uc011bbz.1_5'Flank	NM_177939	NP_808808	Q9NXG6	P4HTM_HUMAN	hypoxia-inducible factor prolyl 4-hydroxylase	387	Lumenal (Potential).|Fe2OG dioxygenase.					endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)|pancreas(1)	2					Vitamin C(DB00126)	AACCTACGATGAAATGGTAAG	0.498			NA											10	124					0	0	0.000978	0	0
FEZF2	55079	broad.mit.edu	37	3	62358282	62358282	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:62358282G>T	uc003dlh.2	-	1	469	c.262C>A	c.(262-264)CTG>ATG	p.L88M	FEZF2_uc003dli.2_Missense_Mutation_p.L88M	NM_018008	NP_060478	Q8TBJ5	FEZF2_HUMAN	FEZ family zinc finger 2	88					transcription, DNA-dependent	nucleus	zinc ion binding			lung(1)	1		Lung SC(41;0.0262)		BRCA - Breast invasive adenocarcinoma(55;0.000221)|KIRC - Kidney renal clear cell carcinoma(15;0.00834)|Kidney(15;0.00957)		TAACTGAGCAGTGTCTTTGAC	0.507	NSCLC(170;1772 2053 12525 15604 23984)		NA											15	27					1.01871e-10	1.77742e-10	0.008871	1	0
WDR52	55779	broad.mit.edu	37	3	113084966	113084966	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:113084966C>T	uc003eae.1	-	19	2681	c.2635G>A	c.(2635-2637)GAT>AAT	p.D879N	WDR52_uc003ead.1_Missense_Mutation_p.D60N	NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	879	WD 9.									central_nervous_system(1)	1						ATATTGCCATCTGCTCCAGCA	0.363			NA											7	52					0	0	0.001984	0	0
FGF12	2257	broad.mit.edu	37	3	192125822	192125822	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:192125822C>T	uc003fsx.2	-	1	1017	c.191G>A	c.(190-192)CGG>CAG	p.R64Q	FGF12_uc003fsy.2_Intron	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	64					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		ACCTGGTCTCCGCCTCACCGG	0.667			NA											13	112					0	0	0.004007	0	0
ATP13A4	84239	broad.mit.edu	37	3	193132463	193132463	+	Silent	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:193132463G>C	uc003ftd.2	-	26	3027	c.2919C>G	c.(2917-2919)CTC>CTG	p.L973L	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	973	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		AAATCACAGAGAGTAGCAGAG	0.463			NA											6	8					0	0	0.001168	0	0
MUC4	4585	broad.mit.edu	37	3	195489086	195489086	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:195489086C>A	uc011bto.1	-	15	14460	c.14000G>T	c.(13999-14001)CGC>CTC	p.R4667L	MUC4_uc003fuz.2_Missense_Mutation_p.R393L|MUC4_uc003fva.2_Missense_Mutation_p.R275L|MUC4_uc003fvb.2_Missense_Mutation_p.R311L|MUC4_uc003fvc.2_RNA|MUC4_uc003fvd.2_RNA|MUC4_uc003fve.2_Missense_Mutation_p.R311L|MUC4_uc010hzr.2_RNA|MUC4_uc011btf.1_Missense_Mutation_p.R275L|MUC4_uc011btg.1_RNA|MUC4_uc011bth.1_Missense_Mutation_p.R359L|MUC4_uc011bti.1_Missense_Mutation_p.R359L|MUC4_uc011btj.1_Missense_Mutation_p.R536L|MUC4_uc011btk.1_Missense_Mutation_p.R275L|MUC4_uc011btl.1_Missense_Mutation_p.R304L|MUC4_uc011btm.1_Missense_Mutation_p.R484L|MUC4_uc011btn.1_Missense_Mutation_p.R275L|MUC4_uc003fvo.2_Missense_Mutation_p.R559L|MUC4_uc003fvp.2_Missense_Mutation_p.R508L	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	1552	VWFD.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAGCCGTTGCGGCTCAGGAG	0.697			NA											3	3					0.004672	0.0064725	0.004672	1	0
RGS12	6002	broad.mit.edu	37	4	3319586	3319586	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:3319586C>T	uc003ggw.2	+	2	2593	c.1689C>T	c.(1687-1689)GGC>GGT	p.G563G	RGS12_uc003ggu.2_Silent_p.G563G|RGS12_uc010ics.1_Intron|RGS12_uc011bvr.1_RNA|RGS12_uc003ggv.2_Silent_p.G563G|RGS12_uc003ggx.1_Silent_p.G563G	NM_198229	NP_937872	O14924	RGS12_HUMAN	regulator of G-protein signalling 12 isoform 1	563						condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CCACCGATGGCTGGTCCAGCA	0.642			NA											19	51					0	0	0.007413	0	0
SLC2A9	56606	broad.mit.edu	37	4	9909889	9909889	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:9909889C>A	uc003gmc.2	-	8	1144	c.1083G>T	c.(1081-1083)GGG>GGT	p.G361G	SLC2A9_uc003gmd.2_Silent_p.G332G	NM_020041	NP_064425	Q9NRM0	GTR9_HUMAN	solute carrier family 2, member 9 protein	361	Helical; Name=8; (Potential).				glucose transport|urate metabolic process	integral to membrane|plasma membrane	sugar:hydrogen symporter activity	p.G332G(1)		ovary(3)	3						TCTCGATGCCCCCTGTACTCA	0.483			NA											11	23					7.03913e-09	1.15564e-08	0.001368	1	0
SLIT2	9353	broad.mit.edu	37	4	20487859	20487859	+	Silent	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:20487859G>T	uc003gpr.1	+	7	780	c.576G>T	c.(574-576)GTG>GTT	p.V192V	SLIT2_uc003gps.1_Silent_p.V192V	NM_004787	NP_004778	O94813	SLIT2_HUMAN	slit homolog 2 precursor	192	LRR 6.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			central_nervous_system(4)|skin(4)|ovary(3)	11						GACTTTCTGTGGCAAGTTTCA	0.274			NA											11	24					2.27111e-07	3.52064e-07	0.001368	1	0
GABRA4	2557	broad.mit.edu	37	4	46994843	46994843	+	Splice_Site	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:46994843A>T	uc003gxg.2	-	2	344	c.205_splice	c.e2+1	p.G69_splice		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4						gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AATCGTTCATACCCCCAAATC	0.378	Ovarian(6;283 369 8234 12290 33402)		NA											9	20					0	0	0.004482	0	0
ADH4	127	broad.mit.edu	37	4	100048406	100048406	+	Silent	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:100048406T>C	uc003hun.2	-	7	1009	c.933A>G	c.(931-933)CCA>CCG	p.P311P	uc003hum.1_Intron|ADH4_uc011ced.1_Silent_p.P330P	NM_000670	NP_000661	P08319	ADH4_HUMAN	class II alcohol dehydrogenase, pi subunit	311					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			skin(2)	2				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	TTAGCTCCTCTGGAAAAATAG	0.408			NA											19	26					0	0	0.001523	0	0
DNAJB14	79982	broad.mit.edu	37	4	100822192	100822192	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:100822192C>T	uc003hvl.2	-	8	1284	c.1133G>A	c.(1132-1134)GGA>GAA	p.G378E	DNAJB14_uc003hvk.2_Missense_Mutation_p.G293E|DNAJB14_uc010ili.2_Missense_Mutation_p.G311E	NM_001031723	NP_001026893	Q8TBM8	DJB14_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 14	378					protein folding	integral to membrane	heat shock protein binding|unfolded protein binding				0				OV - Ovarian serous cystadenocarcinoma(123;4.59e-09)		AGTTCATCCTCCTTTATAAAG	0.378			NA											4	49					0	0	0.000602	0	0
SEC24B	10427	broad.mit.edu	37	4	110394165	110394165	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:110394165G>A	uc003hzk.2	+	3	938	c.883G>A	c.(883-885)GAT>AAT	p.D295N	SEC24B_uc003hzl.2_Missense_Mutation_p.D295N|SEC24B_uc011cfp.1_Missense_Mutation_p.D326N|SEC24B_uc011cfq.1_Missense_Mutation_p.D295N|SEC24B_uc011cfr.1_Missense_Mutation_p.D295N	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	295					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TTCAGTTGCAGATTCTTTATC	0.303			NA											7	52					0	0	0.00308	0	0
KIAA0922	23240	broad.mit.edu	37	4	154556719	154556719	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:154556719C>G	uc003inm.3	+	34	4602	c.4550C>G	c.(4549-4551)TCT>TGT	p.S1517C	KIAA0922_uc010ipp.2_Missense_Mutation_p.S1518C|KIAA0922_uc010ipq.2_Missense_Mutation_p.S1286C	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1517	Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				TTCATCAGCTCTCCGGTCAGT	0.532			NA											8	20					0	0	0.00308	0	0
TLL1	7092	broad.mit.edu	37	4	166999170	166999170	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:166999170C>T	uc003irh.1	+	18	3077	c.2430C>T	c.(2428-2430)CAC>CAT	p.H810H	TLL1_uc011cjn.1_Silent_p.H833H|TLL1_uc011cjo.1_Silent_p.H634H	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	810	CUB 4.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CTCCTGGCCACCGAATCAAAT	0.463			NA											18	24					0	0	0.006122	0	0
ASB5	140458	broad.mit.edu	37	4	177136761	177136761	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr4:177136761T>A	uc003iuq.1	-	7	996	c.980A>T	c.(979-981)CAG>CTG	p.Q327L	ASB5_uc003iup.1_Missense_Mutation_p.Q274L	NM_080874	NP_543150	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box-containing protein	327	SOCS box.				intracellular signal transduction					skin(2)	2		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		TTATCGATACTGTAAGAAATT	0.333			NA											8	13					0	0	0.00308	0	0
KIAA0947	23379	broad.mit.edu	37	5	5457453	5457453	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:5457453G>T	uc003jdm.3	+	12	922	c.700G>T	c.(700-702)GCC>TCC	p.A234S		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	234										ovary(1)|central_nervous_system(1)	2						AGAAAAACCTGCCAAAGCAAT	0.428			NA											10	12					7.03913e-09	1.15564e-08	0.001368	1	0
NSUN2	54888	broad.mit.edu	37	5	6605502	6605502	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:6605502G>A	uc003jdu.2	-	15	1686	c.1621C>T	c.(1621-1623)CCT>TCT	p.P541S	NSUN2_uc003jds.2_5'Flank|NSUN2_uc003jdt.2_Missense_Mutation_p.P305S|NSUN2_uc011cmk.1_Missense_Mutation_p.P506S|NSUN2_uc003jdv.2_Missense_Mutation_p.P305S	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	541						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						GGGAATGAAGGATCCAAAGCA	0.383			NA											7	69					0	0	0.00308	0	0
CDH12	1010	broad.mit.edu	37	5	21783516	21783516	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:21783516G>T	uc010iuc.2	-	8	1802	c.1344C>A	c.(1342-1344)GAC>GAA	p.D448E	CDH12_uc011cno.1_Missense_Mutation_p.D408E|CDH12_uc003jgk.2_Missense_Mutation_p.D448E	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	448	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TGCTTTCTCTGTCTAGTAATT	0.368			NA								HNSCC(59;0.17)			32	75					2.61193e-14	4.8842e-14	0.001786	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33577084	33577084	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:33577084G>T	uc003jia.1	-	19	3210	c.3047C>A	c.(3046-3048)CCA>CAA	p.P1016Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P931Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1016	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TAGTGTTGGTGGGTTTTTTCC	0.537			NA								HNSCC(64;0.19)			43	66					1.96642e-18	3.86791e-18	0.006999	1	0
BDP1	55814	broad.mit.edu	37	5	70785481	70785481	+	Silent	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:70785481G>C	uc003kbp.1	+	10	1727	c.1464G>C	c.(1462-1464)GCG>GCC	p.A488A	BDP1_uc003kbn.1_Silent_p.A488A|BDP1_uc003kbo.2_Silent_p.A488A	NM_018429	NP_060899	A6H8Y1	BDP1_HUMAN	transcription factor-like nuclear regulator	488					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			skin(2)	2		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CTGTTCAGGCGGGTCCTTCTA	0.348			NA											17	28					0	0	0.007413	0	0
FNIP1	96459	broad.mit.edu	37	5	131008179	131008179	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:131008179G>A	uc003kvs.1	-	14	2100	c.1958C>T	c.(1957-1959)TCT>TTT	p.S653F	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.S625F|FNIP1_uc010jdm.1_Missense_Mutation_p.S608F	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	653					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TTGGCAGTCAGAAGGAGAAAT	0.383			NA											9	115					0	0	0.004482	0	0
P4HA2	8974	broad.mit.edu	37	5	131543483	131543483	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:131543483C>G	uc003kwh.2	-	8	1562	c.998G>C	c.(997-999)TGG>TCG	p.W333S	P4HA2_uc003kwg.2_Missense_Mutation_p.W333S|P4HA2_uc003kwi.2_Missense_Mutation_p.W333S|P4HA2_uc003kwk.2_Missense_Mutation_p.W333S|P4HA2_uc003kwl.2_Missense_Mutation_p.W333S|P4HA2_uc003kwj.2_Missense_Mutation_p.W333S	NM_004199	NP_004190	O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha II subunit isoform 1	333						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding				0		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CGGGCTGTCCCACTCGTCCTC	0.527	Esophageal Squamous(68;117 1135 17362 19256 34242)		NA											43	66					0	0	0.002522	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188067	140188067	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:140188067C>A	uc003lhi.2	+	1	1396	c.1295C>A	c.(1294-1296)TCG>TAG	p.S432*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Nonsense_Mutation_p.S432*|PCDHA4_uc011daa.1_Nonsense_Mutation_p.S432*	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	432	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACGGGGGCTCGCCTTCGCTG	0.617			NA											59	64					4.6707e-30	1.03052e-29	0.00361	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553265	140553265	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:140553265C>T	uc003lit.2	+	1	1023	c.849C>T	c.(847-849)TAC>TAT	p.Y283Y		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	protocadherin beta 7 precursor	283	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|central_nervous_system(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CATTTTCTTACGCCACTGAAA	0.428			NA											32	35					0	0	0.002096	0	0
PCDH12	51294	broad.mit.edu	37	5	141335212	141335212	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:141335212C>G	uc003llx.2	-	1	3416	c.2205G>C	c.(2203-2205)TTG>TTC	p.L735F		NM_016580	NP_057664	Q9NPG4	PCD12_HUMAN	protocadherin 12 precursor	735	Helical; (Potential).				neuron recognition	integral to plasma membrane	calcium ion binding			ovary(3)	3		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGACATGAACAAAGCCAGGA	0.592			NA											12	25					0	0	0.000978	0	0
DPYSL3	1809	broad.mit.edu	37	5	146780289	146780289	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:146780289T>A	uc003lon.1	-	10	1186	c.1076A>T	c.(1075-1077)GAG>GTG	p.E359V	DPYSL3_uc003loo.2_Missense_Mutation_p.E473V	NM_001387	NP_001378	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	359					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CATCCGCTCCTCCACACCATT	0.567			NA											27	25					0	0	0.00632	0	0
TNIP1	10318	broad.mit.edu	37	5	150422465	150422465	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:150422465C>T	uc003ltf.2	-	10	1583	c.994G>A	c.(994-996)GAG>AAG	p.E332K	TNIP1_uc010jhl.2_RNA|TNIP1_uc010jhm.2_Missense_Mutation_p.E332K|TNIP1_uc010jhn.2_Missense_Mutation_p.E332K|TNIP1_uc011dco.1_Missense_Mutation_p.E332K|TNIP1_uc003lth.2_RNA|TNIP1_uc003lti.2_Missense_Mutation_p.E332K|TNIP1_uc003ltg.2_Missense_Mutation_p.E279K|TNIP1_uc003ltj.2_Missense_Mutation_p.E332K|TNIP1_uc010jho.1_RNA|TNIP1_uc010jhq.1_Missense_Mutation_p.E279K|TNIP1_uc010jhp.1_Missense_Mutation_p.E279K|TNIP1_uc010jhr.1_Missense_Mutation_p.E332K|TNIP1_uc003ltk.2_Missense_Mutation_p.E332K	NM_006058	NP_006049	Q15025	TNIP1_HUMAN	TNFAIP3 interacting protein 1	332	Potential.|Interacts with Nef.				defense response|glycoprotein biosynthetic process|negative regulation of viral genome replication|translation	cytoplasm|nucleus	protein binding			ovary(1)|central_nervous_system(1)	2		Medulloblastoma(196;0.0911)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCTTCTGCTCATACTGCTGC	0.567			NA											13	231					0	0	0.001855	0	0
ADAM19	8728	broad.mit.edu	37	5	156946889	156946889	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr5:156946889C>A	uc003lwz.2	-	6	622	c.558G>T	c.(556-558)TGG>TGT	p.W186C	ADAM19_uc003lww.1_5'UTR|ADAM19_uc011ddr.1_Missense_Mutation_p.W117C	NM_033274	NP_150377	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19 preproprotein	186					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			ovary(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ACTGAAGAGCCCAGTCCCTGG	0.552			NA											61	73					7.73544e-29	1.68884e-28	0.00361	1	0
FARS2	10667	broad.mit.edu	37	6	5613521	5613521	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:5613521G>C	uc010jnv.1	+	6	1521	c.1185G>C	c.(1183-1185)AAG>AAC	p.K395N	FARS2_uc003mwr.2_Missense_Mutation_p.K395N	NM_006567	NP_006558	O95363	SYFM_HUMAN	phenylalanyl-tRNA synthetase 2 precursor	395	FDX-ACB.				phenylalanyl-tRNA aminoacylation|tRNA processing	mitochondrial matrix|soluble fraction	ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding				0	Ovarian(93;0.11)	all_hematologic(90;0.0104)			L-Phenylalanine(DB00120)	TGGTGGAAAAGGTTGATCTCA	0.378			NA											12	64					0	0	0.000978	0	0
BMP6	654	broad.mit.edu	37	6	7845379	7845379	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:7845379A>G	uc003mxu.3	+	2	849	c.671A>G	c.(670-672)TAC>TGC	p.Y224C		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	224					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					ATAGTGGAGTACGACAAGGAG	0.483			NA											28	63					0	0	0.001786	0	0
CDKAL1	54901	broad.mit.edu	37	6	21108643	21108643	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:21108643G>C	uc003ndc.1	+	13	1422	c.1248G>C	c.(1246-1248)AGG>AGC	p.R416S	CDKAL1_uc003ndd.1_Missense_Mutation_p.R416S|CDKAL1_uc003nde.1_Intron|CDKAL1_uc003ndf.1_Missense_Mutation_p.R12S	NM_017774	NP_060244	Q5VV42	CDKAL_HUMAN	CDK5 regulatory subunit associated protein	416					RNA modification	integral to membrane	4 iron, 4 sulfur cluster binding|metal ion binding|transferase activity			ovary(2)	2	all_epithelial(95;0.0708)|Breast(50;0.131)|Ovarian(93;0.227)		OV - Ovarian serous cystadenocarcinoma(7;0.0241)|all cancers(50;0.123)|Epithelial(50;0.248)			AAAAGCAAAGGACAAAAGATC	0.299			NA											8	30					0	0	0.004482	0	0
LRRC16A	55604	broad.mit.edu	37	6	25600552	25600552	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:25600552A>T	uc011djw.1	+	33	3506	c.3130A>T	c.(3130-3132)ACA>TCA	p.T1044S	LRRC16A_uc010jpx.2_Missense_Mutation_p.T1044S|LRRC16A_uc010jpy.2_Missense_Mutation_p.T1044S	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1044	Inhibits capping activity of CAPZA2 (By similarity).				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GAAATGGTCAACAAGAGGCTC	0.373			NA											31	64					0	0	0.003755	0	0
TNXB	7148	broad.mit.edu	37	6	32036264	32036264	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:32036264G>A	uc003nzl.2	-	17	6325	c.6123C>T	c.(6121-6123)ACC>ACT	p.T2041T		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2123	Fibronectin type-III 13.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGCCCGAGATGGTGACCCCTT	0.607			NA											28	26					0	0	0.00632	0	0
SLC22A7	10864	broad.mit.edu	37	6	43270461	43270461	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:43270461G>T	uc003out.2	+	9	1444	c.1345G>T	c.(1345-1347)GCC>TCC	p.A449S	SLC22A7_uc010jyl.1_Missense_Mutation_p.A450S|SLC22A7_uc003ous.2_Missense_Mutation_p.A447S	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	449	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CTTCACCACTGCCTACCTGTT	0.532			NA											5	12					1.26484e-09	2.15282e-09	0.00308	1	0
AARS2	57505	broad.mit.edu	37	6	44272162	44272162	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:44272162C>A	uc010jza.1	-	13	1864	c.1861G>T	c.(1861-1863)GAT>TAT	p.D621Y	SPATS1_uc003oxg.2_Intron|TMEM151B_uc003oxf.2_Intron	NM_020745	NP_065796	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	621					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			ovary(1)	1	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CTTACCTCATCCACATGCAGC	0.592			NA									OREG0017473	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	37					9.39395e-14	1.74101e-13	0.00632	1	0
MUT	4594	broad.mit.edu	37	6	49426796	49426796	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:49426796C>A	uc003ozg.3	-	2	639	c.384G>T	c.(382-384)AAG>AAT	p.K128N		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	128					fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAATCTCACCCTTAATGTTGT	0.353			NA											17	17					7.05477e-17	1.34947e-16	0.00499	1	0
POPDC3	64208	broad.mit.edu	37	6	105609469	105609469	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr6:105609469G>A	uc003prb.2	-	2	718	c.316C>T	c.(316-318)CGA>TGA	p.R106*	uc003pqz.2_Intron|POPDC3_uc003pra.2_Intron	NM_022361	NP_071756	Q9HBV1	POPD3_HUMAN	popeye protein 3	106						integral to membrane				skin(3)|ovary(2)	5		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TGGAATTCTCGGGCAAAGGTT	0.438			NA											12	75					0	0	0.00245	0	0
PMS2	5395	broad.mit.edu	37	7	6018269	6018269	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:6018269T>C	uc003spl.2	-	13	2320	c.2233A>G	c.(2233-2235)ATA>GTA	p.I745V	PMS2_uc003spj.2_Missense_Mutation_p.I639V|PMS2_uc003spk.2_Missense_Mutation_p.I610V|PMS2_uc011jwl.1_Missense_Mutation_p.I610V|PMS2_uc010ktg.2_Missense_Mutation_p.I434V|PMS2_uc010kte.2_Missense_Mutation_p.I344V|PMS2_uc010ktf.1_Intron	NM_000535	NP_000526	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 isoform	745					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			lung(1)|central_nervous_system(1)	2		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		TTTCTAAATATTTCCAGATTT	0.259			NA	Mis|N|F			colorectal|endometrial|ovarian|medulloblastoma|glioma		Direct_reversal_of_damage|MMR	Lynch_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				5	9					0	0	0.004482	0	0
DPY19L1	23333	broad.mit.edu	37	7	35050942	35050942	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:35050942C>A	uc003tem.3	-	5	596	c.451G>T	c.(451-453)GGA>TGA	p.G151*		NM_015283	NP_056098	Q2PZI1	D19L1_HUMAN	dpy-19-like 1	151						integral to membrane					0						AGAAACTTACCTTCACAGCTT	0.274			NA											12	23					3.27435e-08	5.21147e-08	0.00245	1	0
ABCA13	154664	broad.mit.edu	37	7	48443409	48443409	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:48443409G>T	uc003toq.2	+	39	12028	c.12003G>T	c.(12001-12003)GAG>GAT	p.E4001D	ABCA13_uc010kys.1_Missense_Mutation_p.E1075D|ABCA13_uc003tos.1_Missense_Mutation_p.E827D|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4001	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TTCTGGATGAGCCCACCAGTG	0.577			NA											11	15					3.86212e-05	5.67079e-05	0.008291	1	0
EGFR	1956	broad.mit.edu	37	7	55266427	55266427	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:55266427T>A	uc003tqk.2	+	23	2965	c.2719T>A	c.(2719-2721)TTG>ATG	p.L907M	EGFR_uc010kzg.1_Missense_Mutation_p.L862M|EGFR_uc011kco.1_Missense_Mutation_p.L854M	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	907	Cytoplasmic (Potential).|Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TGTTTGGGAGTTGATGACCTT	0.488			8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			46	58					0	0	0.00361	0	0
SEMA3C	10512	broad.mit.edu	37	7	80433566	80433566	+	Splice_Site	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:80433566T>C	uc003uhj.2	-	8	1221	c.659_splice	c.e8-1	p.E220_splice	SEMA3C_uc011kgw.1_Splice_Site_p.E238_splice|SEMA3C_uc011kgx.1_Splice_Site_p.E72_splice	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor						immune response|response to drug	membrane	receptor activity			ovary(1)	1						ACATAGGTTCTAGAAAAAAAG	0.373			NA											10	16					0	0	0.008291	0	0
ABCB1	5243	broad.mit.edu	37	7	87199522	87199522	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:87199522C>A	uc003uiz.1	-	6	722	c.304G>T	c.(304-306)GGG>TGG	p.G102W	ABCB1_uc011khc.1_Missense_Mutation_p.G102W	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	102	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATGAAGAACCCTGTATCATTG	0.308			NA											11	32					0.000978159	0.00136877	0.000978	1	0
STEAP1	26872	broad.mit.edu	37	7	89790150	89790150	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:89790150A>G	uc003ujx.2	+	3	316	c.116A>G	c.(115-117)AAA>AGA	p.K39R	STEAP1_uc010lem.2_Missense_Mutation_p.K39R	NM_012449	NP_036581	Q9UHE8	STEA1_HUMAN	six transmembrane epithelial antigen of the	39					electron transport chain|ion transport|iron ion homeostasis	cell-cell junction|endosome membrane|integral to plasma membrane	channel activity|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity				0	all_hematologic(106;0.112)					AGCATGCTAAAAAGACCTGTG	0.408			NA											25	52					0	0	0.004656	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519846	113519846	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:113519846C>A	uc010ljy.1	-	4	1332	c.1301G>T	c.(1300-1302)AGC>ATC	p.S434I		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	434					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						GACTTCTTTGCTGCCAGTATG	0.423			NA											50	54					6.03219e-31	1.33799e-30	0.00361	1	0
OPN1SW	611	broad.mit.edu	37	7	128413907	128413907	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:128413907C>G	uc003vnt.3	-	4	723	c.723G>C	c.(721-723)CAG>CAC	p.Q241H		NM_001708	NP_001699	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	241	Cytoplasmic (Potential).				phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity				0						GTTCAGCCTTCTGGGTCGTAG	0.547			NA											24	25					0	0	0.005443	0	0
MKLN1	4289	broad.mit.edu	37	7	131113898	131113898	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:131113898A>T	uc011kpm.1	+	9	1018	c.954A>T	c.(952-954)GAA>GAT	p.E318D	MKLN1_uc011kpl.1_Missense_Mutation_p.E295D|MKLN1_uc010lmh.2_Missense_Mutation_p.E318D|MKLN1_uc003vqs.2_Missense_Mutation_p.E111D	NM_013255	NP_037387	Q9UL63	MKLN1_HUMAN	muskelin 1, intracellular mediator containing	318	Kelch 1.				signal transduction	cytoplasm	protein binding			breast(1)	1	Melanoma(18;0.162)					GAGACACTGAAAAAGAGGCAA	0.413			NA											15	25					0	0	0.00245	0	0
OR9A4	130075	broad.mit.edu	37	7	141619371	141619371	+	Silent	SNP	T	T	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:141619371T>G	uc003vwu.1	+	1	696	c.696T>G	c.(694-696)TCT>TCG	p.S232S		NM_001001656	NP_001001656	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	Melanoma(164;0.0171)					CGTCATCCTCTGGCCGGAGGA	0.483			NA											31	59					0	0	0.002445	0	0
CLCN1	1180	broad.mit.edu	37	7	143029565	143029565	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:143029565C>A	uc003wcr.1	+	11	1307	c.1220C>A	c.(1219-1221)CCA>CAA	p.P407Q	CLCN1_uc011ktc.1_Missense_Mutation_p.P69Q	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	407					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					TTCACCTTCCCACCAGGAATG	0.483			NA											38	44					3.38236e-24	7.05221e-24	0.006999	1	0
CSMD1	64478	broad.mit.edu	37	8	2813272	2813272	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:2813272G>T	uc011kwk.1	-	64	10226	c.9836C>A	c.(9835-9837)CCA>CAA	p.P3279Q	CSMD1_uc011kwj.1_Missense_Mutation_p.P2608Q|CSMD1_uc010lrg.2_Missense_Mutation_p.P1170Q	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	3279	Sushi 28.|Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGGGGTTTCTGGCTGTCTGCA	0.448			NA											53	39					1.54043e-34	3.49109e-34	0.00361	1	0
CSMD1	64478	broad.mit.edu	37	8	3000123	3000123	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:3000123G>T	uc011kwk.1	-	41	6498	c.6108C>A	c.(6106-6108)TAC>TAA	p.Y2036*	CSMD1_uc011kwj.1_Nonsense_Mutation_p.Y1428*|CSMD1_uc010lrg.2_Nonsense_Mutation_p.Y104*	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2036	Extracellular (Potential).|CUB 12.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGCTGGTGTGGTAAGGTCCAT	0.438			NA											67	48					5.10652e-33	1.14485e-32	0.00361	1	0
MFHAS1	9258	broad.mit.edu	37	8	8748915	8748915	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:8748915G>A	uc003wsj.1	-	1	2217	c.1654C>T	c.(1654-1656)CTG>TTG	p.L552L		NM_004225	NP_004216	Q9Y4C4	MFHA1_HUMAN	malignant fibrous histiocytoma amplified	552	Roc.										0		Hepatocellular(245;0.217)		COAD - Colon adenocarcinoma(149;0.124)		TGAATGTCCAGACATTTCTCC	0.657	Melanoma(103;1201 2045 17515 28966)		NA											7	16					0	0	0.00308	0	0
VPS37A	137492	broad.mit.edu	37	8	17132344	17132344	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:17132344A>T	uc003wxj.2	+	5	872	c.519A>T	c.(517-519)TTA>TTT	p.L173F	VPS37A_uc003wxk.2_Missense_Mutation_p.L148F|VPS37A_uc003wxl.2_5'UTR	NM_152415	NP_689628	Q8NEZ2	VP37A_HUMAN	hepatocellular carcinoma related protein 1	173					cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus					0				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		TCACTTCTTTATCTGTTGCTG	0.438			NA											22	6					0	0	0.00278	0	0
DUSP26	78986	broad.mit.edu	37	8	33454976	33454976	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:33454976T>C	uc003xjp.2	-	2	391	c.58A>G	c.(58-60)AGT>GGT	p.S20G	DUSP26_uc003xjq.2_Missense_Mutation_p.S20G	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	20						Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CTTGAGCTACTCCGGGAGAAG	0.552			NA											36	23					0	0	0.006999	0	0
PXDNL	137902	broad.mit.edu	37	8	52321891	52321891	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:52321891G>T	uc003xqu.3	-	17	2394	c.2293C>A	c.(2293-2295)CGC>AGC	p.R765S	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	765					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCGAGCCCGCGGGGCGCGCGG	0.786			NA											6	2					0.00116845	0.00162957	0.001168	1	0
CHD7	55636	broad.mit.edu	37	8	61748737	61748737	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:61748737T>A	uc003xue.2	+	16	4361	c.3884T>A	c.(3883-3885)ATT>AAT	p.I1295N		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1295	Helicase C-terminal.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CTAGTGCTGATTGACAAGCTG	0.473			NA											15	22					0	0	0.003163	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619931	77619931	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:77619931C>T	uc003yav.2	+	3	3050	c.2663C>T	c.(2662-2664)TCT>TTT	p.S888F	ZFHX4_uc003yat.1_Missense_Mutation_p.S888F|ZFHX4_uc003yau.1_Missense_Mutation_p.S914F|ZFHX4_uc003yaw.1_Missense_Mutation_p.S888F	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	888						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAATTCACCTCTGACAGCCTG	0.522			NA								HNSCC(33;0.089)			29	15					0	0	0.001786	0	0
RAD21	5885	broad.mit.edu	37	8	117874162	117874162	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:117874162C>G	uc003yod.2	-	4	580	c.292G>C	c.(292-294)GAG>CAG	p.E98Q		NM_006265	NP_006256	O60216	RAD21_HUMAN	RAD21 homolog	98					apoptosis|cell division|chromosome segregation|double-strand break repair|mitotic metaphase/anaphase transition|mitotic prometaphase|protein localization to chromatin|reciprocal meiotic recombination|regulation of transcription from RNA polymerase II promoter	chromosome, centromeric region|cohesin complex|nuclear chromosome|nucleoplasm	protein binding			lung(1)|skin(1)	2	all_cancers(13;1.21e-21)|Lung NSC(37;0.000134)|Ovarian(258;0.0172)					CGATTTTCCTCAGGCAGGTCA	0.388			NA											10	25					0	0	0.000978	0	0
KIAA2026	158358	broad.mit.edu	37	9	5921057	5921057	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:5921057C>T	uc003zjq.3	-	8	5155	c.4939G>A	c.(4939-4941)GCA>ACA	p.A1647T	KIAA2026_uc010mht.2_Missense_Mutation_p.A822T	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	1647										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ACTGCTCTTGCTGAAGAAACC	0.423			NA											19	31					0	0	0.006122	0	0
PTPRD	5789	broad.mit.edu	37	9	8518092	8518092	+	Silent	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:8518092G>A	uc003zkk.2	-	20	2010	c.1299C>T	c.(1297-1299)ACC>ACT	p.T433T	PTPRD_uc003zkp.2_Silent_p.T433T|PTPRD_uc003zkq.2_Silent_p.T433T|PTPRD_uc003zkr.2_Silent_p.T427T|PTPRD_uc003zks.2_Silent_p.T423T|PTPRD_uc003zkl.2_Silent_p.T433T|PTPRD_uc003zkm.2_Silent_p.T420T|PTPRD_uc003zkn.2_Silent_p.T433T|PTPRD_uc003zko.2_Silent_p.T430T	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	433	Fibronectin type-III 2.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GTACCAAAATGGTGGTCGAAC	0.507			NA								TSP Lung(15;0.13)			42	72					0	0	0.00874	0	0
TAF1L	138474	broad.mit.edu	37	9	32633465	32633466	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:32633465_32633466CC>AA	uc003zrg.1	-	1	2202_2203	c.2112_2113GG>TT	c.(2110-2115)GAGGAA>GATTAA	p.704_705EE>D*	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	704_705					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGTCCATTTTCCTCACTATATT	0.431			NA											31	54					0	0	0.004672	0	0
GADD45G	10912	broad.mit.edu	37	9	92220729	92220729	+	Silent	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:92220729G>T	uc004aqq.2	+	3	413	c.303G>T	c.(301-303)CTG>CTT	p.L101L	GADD45G_uc004aqr.2_Silent_p.L83L	NM_006705	NP_006696	O95257	GA45G_HUMAN	growth arrest and DNA-damage-inducible, gamma	101					activation of MAPKKK activity|apoptosis|cell differentiation|DNA repair|multicellular organismal development		protein binding				0						TGCAGCGGCTGGCGGCTATCG	0.652	Colon(131;320 2336 18973 23919)		NA											10	12					0.00621372	0.00855155	0.006214	1	0
ZNF367	195828	broad.mit.edu	37	9	99160522	99160522	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:99160522G>T	uc004awf.2	-	2	850	c.495C>A	c.(493-495)AGC>AGA	p.S165R	ZNF367_uc004awg.2_Missense_Mutation_p.S165R	NM_153695	NP_710162	Q7RTV3	ZN367_HUMAN	zinc finger protein 367	165					regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Acute lymphoblastic leukemia(62;0.0167)				AACGGATTCTGCTGGATGAAT	0.408			NA											40	73					4.67007e-22	9.54616e-22	0.00874	1	0
C9orf84	158401	broad.mit.edu	37	9	114470151	114470151	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:114470151C>T	uc004bfr.2	-	17	2485	c.2350G>A	c.(2350-2352)GAA>AAA	p.E784K	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfq.2_Missense_Mutation_p.E745K|C9orf84_uc010mug.2_Missense_Mutation_p.E695K	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	784										ovary(2)	2						AAAACACCTTCAGATTCCAGA	0.214			NA											10	103					0	0	0.000978	0	0
PTGS1	5742	broad.mit.edu	37	9	125145816	125145816	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:125145816C>A	uc004bmg.1	+	8	926	c.791C>A	c.(790-792)TCG>TAG	p.S264*	PTGS1_uc011lys.1_Nonsense_Mutation_p.S239*|PTGS1_uc010mwb.1_Nonsense_Mutation_p.S155*|PTGS1_uc004bmf.1_Nonsense_Mutation_p.S264*|PTGS1_uc004bmh.1_Nonsense_Mutation_p.S155*|PTGS1_uc011lyt.1_Nonsense_Mutation_p.S155*	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	264					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TACCCGCCCTCGGTAGAAGAG	0.612			NA											15	13					4.7546e-09	7.89908e-09	0.004007	1	0
DENND1A	57706	broad.mit.edu	37	9	126144289	126144289	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:126144289G>A	uc004bnz.1	-	22	2685	c.2452C>T	c.(2452-2454)CCC>TCC	p.P818S	DENND1A_uc011lzl.1_Missense_Mutation_p.P636S|DENND1A_uc004bny.1_Missense_Mutation_p.P600S|DENND1A_uc011lzm.1_Missense_Mutation_p.P829S|DENND1A_uc010mwh.1_Missense_Mutation_p.P239S	NM_020946	NP_065997	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A isoform 1	818	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			ovary(2)	2						CCTGCAGGGGGGAAGCTGAAT	0.672			NA											5	13					0	0	0.000602	0	0
LRSAM1	90678	broad.mit.edu	37	9	130257628	130257628	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:130257628G>T	uc004brb.1	+	22	1974	c.1629G>T	c.(1627-1629)AGG>AGT	p.R543S	LRSAM1_uc010mxk.1_Missense_Mutation_p.R516S|LRSAM1_uc004brc.1_Missense_Mutation_p.R543S|LRSAM1_uc004brd.1_Missense_Mutation_p.R543S|LRSAM1_uc004bre.1_Missense_Mutation_p.R123S|uc004brf.1_5'Flank|LRSAM1_uc004brg.1_5'UTR	NM_001005373	NP_001005373	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif	543	Potential.				negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding				0						GTGAAACCAGGCAGGAAAATT	0.453			NA											12	19					2.80697e-09	4.70084e-09	0.000978	1	0
TOR1A	1861	broad.mit.edu	37	9	132576287	132576287	+	Silent	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:132576287C>A	uc004byl.2	-	5	1040	c.963G>T	c.(961-963)ACG>ACT	p.T321T	TOR1A_uc004bym.2_RNA	NM_000113	NP_000104	O14656	TOR1A_HUMAN	torsin A precursor	321					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)	1		Ovarian(14;0.00556)				TGGTGAACACCGTTTTGCAGC	0.438			NA											20	27					5.03518e-11	8.85937e-11	0.007413	1	0
PNPLA4	8228	broad.mit.edu	37	X	7889850	7889850	+	Silent	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:7889850C>T	uc011mhq.1	-	4	477	c.315G>A	c.(313-315)GAG>GAA	p.E105E	PNPLA4_uc011mhr.1_Silent_p.E105E|PNPLA4_uc011mhs.1_Silent_p.E18E	NM_004650	NP_004641	P41247	PLPL4_HUMAN	patatin-like phospholipase domain containing 4	105	Patatin.				lipid catabolic process		triglyceride lipase activity				0		Colorectal(8;0.0329)|Medulloblastoma(8;0.232)				TCTGGGCCAGCTCGTGAGCGC	0.443			NA											11	22					0	0	0.008291	0	0
AMELX	265	broad.mit.edu	37	X	11316772	11316772	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:11316772C>A	uc004cut.2	+	5	317	c.249C>A	c.(247-249)CAC>CAA	p.H83Q	ARHGAP6_uc004cup.1_Intron|ARHGAP6_uc004cuo.1_Intron|ARHGAP6_uc004cur.1_Intron|ARHGAP6_uc004cun.1_Intron|ARHGAP6_uc011mif.1_Intron|AMELX_uc004cus.2_Missense_Mutation_p.H97Q|AMELX_uc004cuu.2_Missense_Mutation_p.H67Q	NM_001142	NP_001133	Q99217	AMELX_HUMAN	amelogenin (X chromosome) isoform 1 precursor	83					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel				0						AGCCTCATCACCACATCCCAG	0.602			NA											50	74					1.46357e-32	3.26369e-32	0.00361	1	0
GPM6B	2824	broad.mit.edu	37	X	13795473	13795473	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:13795473C>T	uc004cvz.2	-	5	940	c.649G>A	c.(649-651)GAG>AAG	p.E217K	GPM6B_uc004cvx.2_Missense_Mutation_p.E198K|GPM6B_uc011min.1_Missense_Mutation_p.E131K|GPM6B_uc004cwa.2_Missense_Mutation_p.E198K|GPM6B_uc004cvw.2_Missense_Mutation_p.E257K|GPM6B_uc011mim.1_Missense_Mutation_p.E231K|GPM6B_uc004cvy.2_Missense_Mutation_p.E257K	NM_005278	NP_005269	Q13491	GPM6B_HUMAN	glycoprotein M6B isoform 3	217					cell differentiation|nervous system development	integral to membrane					0						GAGTTTACCTCGTTTGTGTTG	0.433			NA											5	28					0	0	0.000602	0	0
MOSPD2	158747	broad.mit.edu	37	X	14915307	14915307	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:14915307G>T	uc004cwi.2	+	5	512	c.424G>T	c.(424-426)GGG>TGG	p.G142W	MOSPD2_uc004cwj.2_Missense_Mutation_p.G79W	NM_152581	NP_689794	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	142	CRAL-TRIO.					integral to membrane	structural molecule activity			lung(1)	1	Hepatocellular(33;0.183)					GAGGGAAAATGGGAAACCTGT	0.378			NA											34	55					6.97489e-18	1.36551e-17	0.004878	1	0
ZFX	7543	broad.mit.edu	37	X	24197628	24197628	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:24197628G>T	uc004dbf.2	+	4	645	c.387G>T	c.(385-387)ATG>ATT	p.M129I	ZFX_uc004dbd.1_Missense_Mutation_p.M129I|ZFX_uc010nfx.1_Intron|ZFX_uc004dbe.2_Missense_Mutation_p.M129I|ZFX_uc011mjv.1_Missense_Mutation_p.M168I|ZFX_uc010nfy.1_Missense_Mutation_p.M129I	NM_003410	NP_003401	P17010	ZFX_HUMAN	zinc finger protein, X-linked	129					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(2)	2						CAATGTCTATGCCAGAACACG	0.348	Esophageal Squamous(20;306 562 7346 32868 37983)		NA											83	133					3.89792e-41	8.88216e-41	0.00361	1	0
RBM10	8241	broad.mit.edu	37	X	47045157	47045157	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:47045157G>T	uc004dhf.2	+	21	2777	c.2398G>T	c.(2398-2400)GAG>TAG	p.E800*	RBM10_uc004dhg.2_Nonsense_Mutation_p.E722*|RBM10_uc004dhh.2_Nonsense_Mutation_p.E799*|RBM10_uc010nhq.2_Nonsense_Mutation_p.E723*|RBM10_uc004dhi.2_Nonsense_Mutation_p.E865*	NM_005676	NP_005667	P98175	RBM10_HUMAN	RNA binding motif protein 10 isoform 1	800					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			ovary(1)|large_intestine(1)|prostate(1)|breast(1)|pancreas(1)	5						GTCAGAAAACGAGCTAGAAGC	0.572	Melanoma(171;120 2705 19495 39241)		NA											8	13					1.11149e-13	2.04181e-13	0.008291	1	0
TBC1D25	4943	broad.mit.edu	37	X	48418002	48418002	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:48418002G>T	uc004dka.1	+	6	817	c.706G>T	c.(706-708)GTG>TTG	p.V236L	TBC1D25_uc011mly.1_Missense_Mutation_p.V178L|TBC1D25_uc004dkb.1_5'UTR|TBC1D25_uc011mlz.1_5'UTR|TBC1D25_uc011mma.1_5'UTR|TBC1D25_uc004dkc.1_5'UTR|TBC1D25_uc011mmb.1_Missense_Mutation_p.V240L|TBC1D25_uc011mmc.1_5'UTR|TBC1D25_uc011mmd.1_5'UTR	NM_002536	NP_002527	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	236	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			ovary(1)	1						CCCTGGGCAGGTGGTGTGGCG	0.567			NA											11	15					0.000978159	0.00136877	0.000978	1	0
OTUD5	55593	broad.mit.edu	37	X	48781242	48781242	+	Silent	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:48781242G>T	uc004dlu.2	-	7	1427	c.1366C>A	c.(1366-1368)CGG>AGG	p.R456R	OTUD5_uc004dlt.3_Silent_p.R451R|OTUD5_uc004dlv.2_Silent_p.R451R|OTUD5_uc011mmp.1_Silent_p.R234R	NM_017602	NP_060072	Q96G74	OTUD5_HUMAN	OTU domain containing 5 isoform a	456					negative regulation of type I interferon production		cysteine-type peptidase activity			pancreas(1)	1						GCTGAACTCCGCTGCCGCGGG	0.637			NA											7	13					2.0095e-06	3.04713e-06	0.001984	1	0
RIBC1	158787	broad.mit.edu	37	X	53457342	53457342	+	Splice_Site	SNP	A	A	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:53457342A>G	uc004dsk.2	+	7	817	c.664_splice	c.e7-2	p.A222_splice	RIBC1_uc011mog.1_Splice_Site_p.A107_splice	NM_001031745	NP_001026915	Q8N443	RIBC1_HUMAN	RIB43A domain with coiled-coils 1 isoform 1												0						GGGCTCCACCAGGCAGCTGTG	0.587			NA											12	10					0	0	0.001368	0	0
ZCCHC13	389874	broad.mit.edu	37	X	73524388	73524388	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:73524388G>T	uc004ebs.3	+	1	364	c.287G>T	c.(286-288)AGA>ATA	p.R96I		NM_203303	NP_976048	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	96	CCHC-type 4.						nucleic acid binding|zinc ion binding				0						ACCTGCGGCAGACTAGGACAT	0.517			NA											34	39					2.48696e-23	5.13397e-23	0.003271	1	0
BRWD3	254065	broad.mit.edu	37	X	79932688	79932688	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:79932688C>A	uc004edt.2	-	41	5092	c.4829G>T	c.(4828-4830)GGA>GTA	p.G1610V	BRWD3_uc010nmi.1_RNA|BRWD3_uc004edo.2_Missense_Mutation_p.G1206V|BRWD3_uc004edp.2_Missense_Mutation_p.G1439V|BRWD3_uc004edq.2_Missense_Mutation_p.G1206V|BRWD3_uc010nmj.1_Missense_Mutation_p.G1206V|BRWD3_uc004edr.2_Missense_Mutation_p.G1280V|BRWD3_uc004eds.2_Missense_Mutation_p.G1206V|BRWD3_uc004edu.2_Missense_Mutation_p.G1280V|BRWD3_uc004edv.2_Missense_Mutation_p.G1206V|BRWD3_uc004edw.2_Missense_Mutation_p.G1206V|BRWD3_uc004edx.2_Missense_Mutation_p.G1206V|BRWD3_uc004edy.2_Missense_Mutation_p.G1206V|BRWD3_uc004edz.2_Missense_Mutation_p.G1280V|BRWD3_uc004eea.2_Missense_Mutation_p.G1280V|BRWD3_uc004eeb.2_Missense_Mutation_p.G1206V|uc004edn.1_5'Flank	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	1610										ovary(4)	4						TAAACTGGATCCTAACTCTCC	0.299			NA											43	57					9.14704e-12	1.6441e-11	0.00874	1	0
POU3F4	5456	broad.mit.edu	37	X	82763435	82763435	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:82763435C>A	uc004eeg.2	+	1	167	c.103C>A	c.(103-105)CAG>AAG	p.Q35K		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	35					sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCGCAACCCTCAGAAACTTCT	0.597			NA											9	16					3.09899e-07	4.78621e-07	0.004482	1	0
POU3F4	5456	broad.mit.edu	37	X	82764250	82764251	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:82764250_82764251GG>TT	uc004eeg.2	+	1	982_983	c.918_919GG>TT	c.(916-921)CAGGAG>CATTAG	p.306_307QE>H*		NM_000307	NP_000298	P49335	PO3F4_HUMAN	POU domain, class 3, transcription factor 4	306_307	Homeobox.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTGCCGCGCAGGAGATCTCCTC	0.569			NA											13	7					0	0	0.004672	0	0
TEX13B	56156	broad.mit.edu	37	X	107224606	107224606	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:107224606G>T	uc004enn.1	-	3	736	c.643C>A	c.(643-645)CAG>AAG	p.Q215K		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	215										ovary(1)	1						CCCAGCCCCTGCAAGACCTCT	0.597			NA											51	152					6.08268e-21	1.22535e-20	0.00361	1	0
NKRF	55922	broad.mit.edu	37	X	118724577	118724577	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:118724577C>G	uc004erq.2	-	2	1464	c.811G>C	c.(811-813)GTA>CTA	p.V271L	NKRF_uc004err.2_Missense_Mutation_p.V271L	NM_017544	NP_060014	O15226	NKRF_HUMAN	transcription factor NRF	271	Active repression domain.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			ovary(1)|central_nervous_system(1)	2						AAGAGTTTTACAGCTAGCTCT	0.453			NA											49	64					0	0	0.00361	0	0
SOX3	6658	broad.mit.edu	37	X	139586865	139586865	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:139586865C>A	uc004fbd.1	-	1	361	c.361G>T	c.(361-363)GGC>TGC	p.G121C		NM_005634	NP_005625	P41225	SOX3_HUMAN	SRY (sex determining region Y)-box 3	121					face development|hypothalamus development|negative regulation of neuron differentiation|pituitary gland development|regulation of transcription, DNA-dependent|sensory organ development|sex determination|transcription, DNA-dependent	nucleus	DNA binding			pancreas(1)	1	Acute lymphoblastic leukemia(192;7.65e-05)					CTGCTGCCGCCGCCCGAGTTC	0.726			NA											10	12					0.00621372	0.00855155	0.006214	1	0
FMR1	2332	broad.mit.edu	37	X	147011469	147011469	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:147011469G>T	uc010nst.2	+	6	611	c.422G>T	c.(421-423)TGT>TTT	p.C141F	FMR1_uc011mwz.1_Missense_Mutation_p.C141F|FMR1_uc004fcj.2_Missense_Mutation_p.C141F|FMR1_uc004fck.3_Missense_Mutation_p.C141F|FMR1_uc004fcl.3_Missense_Mutation_p.C2F|FMR1_uc011mxa.1_5'Flank	NM_002024	NP_002015	Q06787	FMR1_HUMAN	fragile X mental retardation 1	141					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					atttCTAGGTGTGCCAAAGAG	0.323			NA							Fragile_X_syndrome				14	16					9.31168e-06	1.39175e-05	0.001855	1	0
AFF2	2334	broad.mit.edu	37	X	147743891	147743891	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:147743891T>C	uc004fcp.2	+	3	1122	c.643T>C	c.(643-645)TCT>CCT	p.S215P	AFF2_uc004fco.2_Missense_Mutation_p.S211P|AFF2_uc004fcq.2_Missense_Mutation_p.S211P|AFF2_uc004fcr.2_Missense_Mutation_p.S211P|AFF2_uc011mxb.1_Missense_Mutation_p.S215P|AFF2_uc004fcs.2_Missense_Mutation_p.S211P	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	215					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					GTCAAACCCATCTGCAAAGGA	0.453			NA											9	222					0	0	0.004482	0	0
CNGA2	1260	broad.mit.edu	37	X	150912084	150912084	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:150912084A>T	uc004fey.1	+	7	1333	c.1109A>T	c.(1108-1110)AAT>ATT	p.N370I		NM_005140	NP_005131	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	370	Helical; Name=H5; (Potential).				response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ATCGTGGGAAATGTGGGCTCC	0.512			NA											48	60					0	0	0.00361	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092682	151092682	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:151092682C>A	uc004fez.2	+	3	702	c.546C>A	c.(544-546)TGC>TGA	p.C182*	MAGEA4_uc004ffa.2_Nonsense_Mutation_p.C182*|MAGEA4_uc004ffb.2_Nonsense_Mutation_p.C182*|MAGEA4_uc004ffc.2_Nonsense_Mutation_p.C182*|MAGEA4_uc004ffd.2_Nonsense_Mutation_p.C182*	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	182	MAGE.						protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TTGTCACCTGCCTGGGCCTTT	0.532			NA											64	89					7.05995e-25	1.4794e-24	0.00361	1	0
PNMA5	114824	broad.mit.edu	37	X	152159340	152159340	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:152159340G>T	uc010ntw.2	-	3	1142	c.803C>A	c.(802-804)CCC>CAC	p.P268H	PNMA5_uc004fha.3_Missense_Mutation_p.P268H|PNMA5_uc010ntx.2_Missense_Mutation_p.P268H|PNMA5_uc004fgy.3_Missense_Mutation_p.P268H	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	268					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCAGCAGGGGCTCTAAGCG	0.537			NA											21	46					1.22574e-08	1.99661e-08	0.002299	1	0
DUSP9	1852	broad.mit.edu	37	X	152914840	152914840	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:152914840C>A	uc004fhx.3	+	3	731	c.527C>A	c.(526-528)TCC>TAC	p.S176Y	DUSP9_uc004fhy.3_Missense_Mutation_p.S176Y	NM_001395	NP_001386	Q99956	DUS9_HUMAN	dual specificity phosphatase 9	176					inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)	2	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GATGCGGAATCCGAGGCTGAC	0.701			NA											21	16					2.89027e-11	5.12869e-11	0.002299	1	0
FUNDC2	65991	broad.mit.edu	37	X	154261779	154261779	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chrX:154261779G>A	uc004fmw.2	+	2	385	c.235G>A	c.(235-237)GAA>AAA	p.E79K		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	79						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ACCTTCAGCAGAAAAGTATAG	0.463			NA											6	127					0	0	0.001984	0	0
MSH4	4438	broad.mit.edu	37	1	76347047	76347047	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:76347047delC	uc001dhd.1	+	14	1939	c.1898delC	c.(1897-1899)TCTfs	p.S633fs		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	633					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						TGCACTCTTTCTGACTATGGT	0.299			NA						MMR					29	31	---	---	---	---	NA	NA	NA	NA	NA
TCHH	7062	broad.mit.edu	37	1	152079960	152079960	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr1:152079960delC	uc001ezp.2	-	2	5733	c.5733delG	c.(5731-5733)CGGfs	p.R1911fs	TCHH_uc009wne.1_Frame_Shift_Del_p.R1911fs	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	1911					keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTCCAGAAGCCGCCCATGGC	0.567			NA											35	122	---	---	---	---	NA	NA	NA	NA	NA
GAS2	2620	broad.mit.edu	37	11	22747844	22747844	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr11:22747844delC	uc009yie.2	+	4	580	c.274delC	c.(274-276)CCGfs	p.P92fs	GAS2_uc001mqm.2_Frame_Shift_Del_p.P92fs|GAS2_uc001mqn.2_RNA|GAS2_uc001mqo.2_Frame_Shift_Del_p.P92fs	NM_001143830	NP_001137302	O43903	GAS2_HUMAN	growth arrest-specific 2	92	CH.				cell cycle arrest|cellular component disassembly involved in apoptosis|regulation of cell shape	actin filament|cytosol|membrane				ovary(1)|skin(1)	2						TCAGAATCTACCGTTGAAGAA	0.383			NA											23	37	---	---	---	---	NA	NA	NA	NA	NA
ADNP2	22850	broad.mit.edu	37	18	77895677	77895681	+	Frame_Shift_Del	DEL	TGGGG	TGGGG	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	TGGGG	TGGGG	-	-	TGGGG	TGGGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr18:77895677_77895681delTGGGG	uc002lnw.2	+	4	2836_2840	c.2381_2385delTGGGG	c.(2380-2385)CTGGGGfs	p.L794fs		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	794_795					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		AATAGGCACCTGGGGAAGAAGAAGT	0.459			NA											24	76	---	---	---	---	NA	NA	NA	NA	NA
NEB	4703	broad.mit.edu	37	2	152512848	152512870	+	Frame_Shift_Del	DEL	TTTTTCTTGTACTCCCGATCAGA	TTTTTCTTGTACTCCCGATCAGA	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	TTTTTCTTGTACTCCCGATCAGA	TTTTTCTTGTACTCCCGATCAGA	-	-	TTTTTCTTGTACTCCCGATCAGA	TTTTTCTTGTACTCCCGATCAGA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr2:152512848_152512870delTTTTTCTTGTACTCCCGATCAGA	uc010fnx.2	-	49	6483_6505	c.6292_6314delTCTGATCGGGAGTACAAGAAAAA	c.(6292-6315)TCTGATCGGGAGTACAAGAAAAACfs	p.S2098fs		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	2098_2105	Nebulin 55.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTTCTCATAGTTTTTCTTGTACTCCCGATCAGATTGCATCTTA	0.466			NA											17	94	---	---	---	---	NA	NA	NA	NA	NA
TAF4	6874	broad.mit.edu	37	20	60581656	60581656	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr20:60581656delG	uc002ybs.2	-	7	2133	c.2133delC	c.(2131-2133)GCCfs	p.A711fs		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	711					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TGGTCACGGTGGCCGCCGTCT	0.721			NA											7	9	---	---	---	---	NA	NA	NA	NA	NA
ZIC4	84107	broad.mit.edu	37	3	147114028	147114028	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr3:147114028delC	uc003ewd.1	-	3	572	c.299delG	c.(298-300)GGCfs	p.G100fs	ZIC4_uc003ewc.1_Frame_Shift_Del_p.G30fs|ZIC4_uc011bno.1_Frame_Shift_Del_p.G150fs	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	100						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CAGGTTCATGCCCCCGTAGCC	0.687			NA											14	16	---	---	---	---	NA	NA	NA	NA	NA
C7orf51	222950	broad.mit.edu	37	7	100084609	100084609	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr7:100084609delG	uc003uvd.1	+	3	393	c.234delG	c.(232-234)ATGfs	p.M78fs	C7orf51_uc003uve.1_5'Flank	NM_173564	NP_775835	Q6ZVC0	CG051_HUMAN	hypothetical protein FLJ37538	78										skin(1)	1	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCAGCGCCATGGCCCCACGCT	0.721			NA											5	8	---	---	---	---	NA	NA	NA	NA	NA
CSMD3	114788	broad.mit.edu	37	8	113694670	113694671	+	Splice_Site	DEL	CC	CC	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr8:113694670_113694671delCC	uc003ynu.2	-	16	2836	c.2677_splice	c.e16+1	p.A893_splice	CSMD3_uc003yns.2_Splice_Site_p.A165_splice|CSMD3_uc003ynt.2_Splice_Site_p.A853_splice|CSMD3_uc011lhx.1_Splice_Site_p.A789_splice	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1							integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACTACACTTACCTCCACATTTT	0.351			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			11	77	---	---	---	---	NA	NA	NA	NA	NA
FAM75C1	441452	broad.mit.edu	37	9	90537868	90537868	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:90537868delG	uc010mqi.2	+	4	3075	c.3046delG	c.(3046-3048)GGAfs	p.G1016fs	FAM75C1_uc004apq.3_Frame_Shift_Del_p.G999fs	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						AAGCCACTTTGGAGAAAACAT	0.428			NA											23	21	---	---	---	---	NA	NA	NA	NA	NA
Unknown	0	broad.mit.edu	37	9	90744923	90744923	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7158-01A-11D-2036-08	TCGA-78-7158-10A-01D-2036-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	199bbb0f-996c-40c1-b06d-2066f04be778	3f4bced4-f89a-43d2-9c5f-6f9683897fa7	g.chr9:90744923delC	uc011lti.1	-	4	3058	c.3029delG	c.(3028-3030)GGAfs	p.G1010fs	uc004apx.1_5'Flank					SubName: Full=cDNA FLJ59639;												NA						GATGTTTTCTCCAAAGTGGCT	0.433			NA											36	202	---	---	---	---	NA	NA	NA	NA	NA