Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GRIK3	2899	broad.mit.edu	37	1	37346266	37346266	+	Silent	SNP	C	C	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr1:37346266C>G	uc001caz.2	-	3	654	c.519G>C	c.(517-519)CGG>CGC	p.R173R	GRIK3_uc001cba.1_Silent_p.R173R	NM_000831	NP_000822	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	173	Extracellular (Potential).				negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)|breast(1)	7		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CGGTGGCTGACCGCCACTTGA	0.622			NA											69	210					0	0	0.01441	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144879561	144879561	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr1:144879561A>G	uc001elw.3	-	27	4180	c.3889T>C	c.(3889-3891)TGT>CGT	p.C1297R	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.C1253R|PDE4DIP_uc001elv.3_Missense_Mutation_p.C304R	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1297					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TGCTCCTCACACTCTGAAAAA	0.502			NA	T	PDGFRB	MPD								4	55					0	0	0.001168	0	0
TRIM68	55128	broad.mit.edu	37	11	4623587	4623587	+	Missense_Mutation	SNP	C	C	T	rs150937700	byFrequency	TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:4623587C>T	uc001lzf.1	-	4	816	c.578G>A	c.(577-579)CGA>CAA	p.R193Q	TRIM68_uc001lzg.1_5'UTR|TRIM68_uc010qyj.1_RNA|TRIM68_uc009yek.1_Missense_Mutation_p.R193Q	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	193					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTCTAGTAATCGCTGGTATTT	0.517			NA											10	53					0	0	0.006214	0	0
OR51T1	401665	broad.mit.edu	37	11	4903940	4903940	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:4903940C>A	uc010qyp.1	+	1	892	c.892C>A	c.(892-894)CCA>ACA	p.P298T		NM_001004759	NP_001004759	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCACTCCACCCCAAGGGTGCT	0.493			NA											9	136					2.17888e-05	6.59552e-05	0.006214	1	0
OR51M1	390059	broad.mit.edu	37	11	5410836	5410836	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:5410836C>A	uc010qzc.1	+	1	208	c.208C>A	c.(208-210)CCC>ACC	p.P70T	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron|OR51B5_uc001maq.1_Intron	NM_001004756	NP_001004756	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M,	70						integral to membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTGCACACACCCATGTACTA	0.468			NA											7	115					8.12818e-05	0.000239568	0.001984	1	0
OR2AG1	144125	broad.mit.edu	37	11	6806758	6806758	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:6806758A>G	uc001mer.1	+	1	490	c.490A>G	c.(490-492)ATG>GTG	p.M164V		NM_001004489	NP_001004489	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG,	164	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CGTGTATACCATGCACTATCC	0.532			NA											5	108					0	0	0.000602	0	0
GRM5	2915	broad.mit.edu	37	11	88337977	88337977	+	Missense_Mutation	SNP	G	G	A	rs148343362		TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:88337977G>A	uc001pcq.2	-	4	1503	c.1303C>T	c.(1303-1305)CGG>TGG	p.R435W	GRM5_uc009yvm.2_Missense_Mutation_p.R435W	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	435	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAAAGTTTCCGTCCATCAATT	0.483			NA											33	53					0	0	0.010818	0	0
CNTN5	53942	broad.mit.edu	37	11	99872788	99872788	+	Silent	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:99872788G>A	uc001pga.2	+	9	1239	c.900G>A	c.(898-900)CCG>CCA	p.P300P	CNTN5_uc009ywv.1_Silent_p.P300P|CNTN5_uc001pfz.2_Silent_p.P300P|CNTN5_uc001pgb.2_Silent_p.P226P	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	300	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AATATGAGCCGAAAATTGAGG	0.363			NA											7	24					0	0	0.006214	0	0
ATXN2	6311	broad.mit.edu	37	12	111923133	111923133	+	Silent	SNP	A	A	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr12:111923133A>C	uc001tsj.2	-	18	3102	c.2940T>G	c.(2938-2940)CCT>CCG	p.P980P	ATXN2_uc001tsh.2_Silent_p.P715P|ATXN2_uc001tsi.2_Silent_p.P691P|ATXN2_uc001tsk.2_Intron|ATXN2_uc001tsg.2_Silent_p.P166P	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2	980	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TTGGGTATAAAGGCTTGAGAG	0.373			NA											46	96					0	0	0.01441	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561096	32561096	+	Silent	SNP	T	T	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr14:32561096T>C	uc001wrl.2	+	2	1460	c.1221T>C	c.(1219-1221)ACT>ACC	p.T407T	ARHGAP5_uc001wrm.2_Silent_p.T407T|ARHGAP5_uc001wrn.2_Silent_p.T407T|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	407	FF 2.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TCCTGAGCACTTTAGAAGCTG	0.378	NSCLC(9;77 350 3443 29227 41353)		NA											24	86					0	0	0.004656	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42446614	42446614	+	Missense_Mutation	SNP	G	G	A	rs142310375		TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr15:42446614G>A	uc001zoz.2	-	3	290	c.227C>T	c.(226-228)GCG>GTG	p.A76V	PLA2G4F_uc010bcr.2_5'UTR|PLA2G4F_uc001zpa.2_5'UTR|PLA2G4F_uc010bcs.2_5'UTR	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	76	C2.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			ovary(4)	4		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GCTTGGGGACGCCGTGGGCAG	0.592			NA											8	24					0	0	0.00308	0	0
UNC45A	55898	broad.mit.edu	37	15	91482981	91482981	+	Silent	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr15:91482981G>A	uc002bqg.2	+	5	787	c.447G>A	c.(445-447)ACG>ACA	p.T149T	UNC45A_uc002bqd.2_Silent_p.T134T|UNC45A_uc010uqo.1_Silent_p.T141T|UNC45A_uc010uqp.1_RNA|UNC45A_uc010uqq.1_Silent_p.T149T	NM_018671	NP_061141	Q9H3U1	UN45A_HUMAN	smooth muscle cell associated protein-1 isoform	149					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			ovary(2)	2	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TGTCCTCGACGGATGCCAAAG	0.483			NA											27	29					0	0	0.012213	0	0
DPP9	91039	broad.mit.edu	37	19	4695514	4695514	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr19:4695514A>G	uc002mba.2	-	12	1487	c.1229T>C	c.(1228-1230)CTC>CCC	p.L410P	DPP9_uc002mbb.2_Missense_Mutation_p.L410P|DPP9_uc002mbc.2_Intron	NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	381					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		GGCCGGGGGGAGGAGGACGAG	0.647			NA											2	6					0	0	0.004672	0	0
GRIK5	2901	broad.mit.edu	37	19	42558472	42558472	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr19:42558472C>T	uc002osj.1	-	8	1091	c.1056G>A	c.(1054-1056)ATG>ATA	p.M352I	GRIK5_uc010eib.1_Missense_Mutation_p.M271I	NM_002088	NP_002079	Q16478	GRIK5_HUMAN	glutamate receptor KA2 precursor	352	Extracellular (Potential).					cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity				0		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TCGGGCTCACCATGCGCAGGT	0.647			NA											18	45					0	0	0.008871	0	0
EPCAM	4072	broad.mit.edu	37	2	47601056	47601056	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:47601056C>G	uc002rvx.2	+	3	652	c.294C>G	c.(292-294)GAC>GAG	p.D98E	EPCAM_uc002rvw.2_Missense_Mutation_p.D126E	NM_002354	NP_002345	P16422	EPCAM_HUMAN	epithelial cell adhesion molecule precursor	98	Extracellular (Potential).|Thyroglobulin type-1.				positive regulation of cell proliferation	apical plasma membrane|basolateral plasma membrane|integral to membrane|lateral plasma membrane|tight junction	protein binding			skin(1)	1						ATGATCCTGACTGCGATGAGA	0.507			NA							Lynch_syndrome				3	50					0	0	0.004672	0	0
REL	5966	broad.mit.edu	37	2	61149129	61149129	+	Missense_Mutation	SNP	C	C	T	rs144119768	by1000genomes	TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:61149129C>T	uc002sam.1	+	11	1543	c.1319C>T	c.(1318-1320)TCG>TTG	p.S440L	REL_uc002san.1_Missense_Mutation_p.S408L	NM_002908	NP_002899	Q04864	REL_HUMAN	v-rel reticuloendotheliosis viral oncogene	440					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|breast(1)	3	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			CCTTCTAATTCGCAAGGTATC	0.458			NA	A		Hodgkin Lymphoma								11	66					0	0	0.010729	0	0
RAB6C	84084	broad.mit.edu	37	2	130738399	130738399	+	Silent	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:130738399C>T	uc002tpx.1	+	1	1165	c.711C>T	c.(709-711)TTC>TTT	p.F237F	uc002tpw.1_5'Flank	NM_032144	NP_115520	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	237					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			lung(1)	1	Colorectal(110;0.1)					TGAACCTTTTCCCTTCATTAA	0.428			NA											9	69					0	0	0.008291	0	0
ARPC2	10109	broad.mit.edu	37	2	219099087	219099087	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:219099087G>T	uc002vhd.2	+	5	347	c.235G>T	c.(235-237)GTG>TTG	p.V79L	ARPC2_uc002vhe.2_Missense_Mutation_p.V79L|ARPC2_uc002vhf.2_5'Flank	NM_152862	NP_690601	O15144	ARPC2_HUMAN	actin related protein 2/3 complex subunit 2	79					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		ATTAAAGAGGGTGTACGGGAG	0.343			NA											12	76					3.27435e-08	1.07861e-07	0.00245	1	0
DOCK10	55619	broad.mit.edu	37	2	225630503	225630503	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:225630503G>C	uc010fwz.1	-	56	6735	c.6496C>G	c.(6496-6498)CGA>GGA	p.R2166G	DOCK10_uc002vob.2_Missense_Mutation_p.R2160G|DOCK10_uc002voa.2_Missense_Mutation_p.S847W	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	2166							GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTAATTACTCGAGTGCAGGTT	0.502			NA											8	25					0	0	0.006214	0	0
FAM65C	140876	broad.mit.edu	37	20	49247380	49247380	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr20:49247380G>A	uc002xvm.2	-	2	323	c.5C>T	c.(4-6)TCG>TTG	p.S2L	FAM65C_uc010zyt.1_Missense_Mutation_p.S6L|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.S2L	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	2										ovary(2)	2						CAACCTCACCGACATGGTGGT	0.662			NA											4	18					0	0	0.000602	0	0
FOXRED2	80020	broad.mit.edu	37	22	36902334	36902334	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr22:36902334C>T	uc003apn.3	-	1	244	c.136G>A	c.(136-138)GCC>ACC	p.A46T	FOXRED2_uc003apo.3_Missense_Mutation_p.A46T|FOXRED2_uc003app.3_Missense_Mutation_p.A46T	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	46					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						AGGAAGTAGGCCATCTGCAGG	0.736			NA											5	4					0	0	0.000602	0	0
TUBB	203068	broad.mit.edu	37	6	30691480	30691480	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr6:30691480C>A	uc003nrl.2	+	4	768	c.641C>A	c.(640-642)ACT>AAT	p.T214N	TUBB_uc003nrk.1_Missense_Mutation_p.T214N|TUBB_uc011dmq.1_Missense_Mutation_p.T142N	NM_178014	NP_821133	P07437	TBB5_HUMAN	tubulin, beta	214					cellular component movement|G2/M transition of mitotic cell cycle|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			ovary(1)	1					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	TGCTTCCGCACTCTGAAGCTG	0.537			NA											4	105					1.024e-07	3.2768e-07	0.000602	1	0
TMEM63B	55362	broad.mit.edu	37	6	44102330	44102330	+	Silent	SNP	C	C	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr6:44102330C>G	uc003owr.2	+	2	73	c.9C>G	c.(7-9)CCC>CCG	p.P3P	TMEM63B_uc003owq.1_Silent_p.P3P|TMEM63B_uc010jyy.1_5'UTR|TMEM63B_uc003ows.2_5'Flank	NM_018426	NP_060896	Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	3						integral to membrane	nucleotide binding|protein binding			pancreas(2)|central_nervous_system(1)	3	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CCATGCTGCCCTTTCTGCTGG	0.652			NA											10	21					0	0	0.006214	0	0
LPA	4018	broad.mit.edu	37	6	160999606	160999606	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr6:160999606T>G	uc003qtl.2	-	28	4540	c.4420A>C	c.(4420-4422)ACA>CCA	p.T1474P		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	3982	Kringle 35.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GTGGGAGTTGTGAGGACACTC	0.498			NA											6	109					0	0	0.00308	0	0
CHD7	55636	broad.mit.edu	37	8	61766029	61766029	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr8:61766029G>A	uc003xue.2	+	31	7222	c.6745G>A	c.(6745-6747)GAT>AAT	p.D2249N		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2249	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGAGGATGACGATAAGTCGGA	0.522			NA											5	53					0	0	0.000602	0	0
CSMD3	114788	broad.mit.edu	37	8	113402962	113402962	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr8:113402962G>C	uc003ynu.2	-	36	6024	c.5865C>G	c.(5863-5865)TAC>TAG	p.Y1955*	CSMD3_uc003yns.2_Nonsense_Mutation_p.Y1157*|CSMD3_uc003ynt.2_Nonsense_Mutation_p.Y1915*|CSMD3_uc011lhx.1_Nonsense_Mutation_p.Y1851*	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1955	Extracellular (Potential).|CUB 11.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AAGGCTCAGGGTATCCAGGTG	0.398			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	34					0	0	0.00499	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20181107	20181107	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:20181107C>T	uc004czu.2	-	19	1816	c.1816G>A	c.(1816-1818)GTC>ATC	p.V606I	RPS6KA3_uc011mjk.1_Missense_Mutation_p.V576I|RPS6KA3_uc004czv.2_Missense_Mutation_p.V593I|RPS6KA3_uc011mjl.1_Missense_Mutation_p.V577I|RPS6KA3_uc011mjm.1_Missense_Mutation_p.V578I	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	606	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						TAGAGTAGGACACCAAGACTC	0.338			NA											39	61					0	0	0.013114	0	0
XK	7504	broad.mit.edu	37	X	37553663	37553663	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:37553663C>A	uc004ddq.2	+	2	452	c.370C>A	c.(370-372)CAG>AAG	p.Q124K		NM_021083	NP_066569	P51811	XK_HUMAN	membrane transport protein XK	124	Extracellular (Potential).				amino acid transport	integral to membrane	protein binding|transporter activity				0		all_lung(315;0.175)				GGAGGTGGGCCAGGCAGAAGG	0.537			NA											7	6					2.0095e-06	6.25177e-06	0.001984	1	0
VSIG1	340547	broad.mit.edu	37	X	107310218	107310218	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:107310218G>A	uc004eno.2	+	3	427	c.266G>A	c.(265-267)CGA>CAA	p.R89Q	VSIG1_uc011msk.1_Missense_Mutation_p.R125Q	NM_182607	NP_872413	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	89	Extracellular (Potential).|Ig-like V-type 1.					integral to membrane		p.R89G(1)		upper_aerodigestive_tract(1)|ovary(1)	2						TTTAAAGATCGAATTACAGGG	0.438			NA											8	95					0	0	0.00308	0	0
ARHGAP4	393	broad.mit.edu	37	X	153184369	153184369	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:153184369C>A	uc004fjk.1	-	7	991	c.949G>T	c.(949-951)GAC>TAC	p.D317Y	ARHGAP4_uc011mzf.1_Missense_Mutation_p.D294Y|ARHGAP4_uc004fjl.1_Missense_Mutation_p.D357Y|ARHGAP4_uc010nup.1_RNA	NM_001666	NP_001657	P98171	RHG04_HUMAN	Rho GTPase activating protein 4 isoform 2	317					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(1)	1	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGGCTTTGTCCCCTGGAGGA	0.647			NA											6	71					0.00116845	0.00335554	0.001168	1	0
SCN8A	6334	broad.mit.edu	37	12	52200312	52200313	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr12:52200312_52200313insT	uc001ryw.2	+	27	5220_5221	c.5042_5043insT	c.(5041-5043)GGTfs	p.G1681fs		NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	1681	IV.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CACGAGGCTGGTATCGATGACA	0.485			NA											29	88	---	---	---	---	NA	NA	NA	NA	NA
BTBD3	22903	broad.mit.edu	37	20	11899098	11899100	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	AAG	AAG	-	-	AAG	AAG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr20:11899098_11899100delAAG	uc002wnz.2	+	1	534_536	c.175_177delAAG	c.(175-177)AAGdel	p.K61del	BTBD3_uc002wny.2_5'UTR|BTBD3_uc002woa.2_5'UTR|BTBD3_uc010zrf.1_5'UTR|BTBD3_uc010zrg.1_5'Flank|BTBD3_uc010zrh.1_5'Flank	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	61										ovary(2)|central_nervous_system(1)	3						GAAGACTAAAAAGAAGAAGATGG	0.379			NA											44	185	---	---	---	---	NA	NA	NA	NA	NA
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr21:10944697delA	uc002yip.1	-	11	905	c.537delT	c.(535-537)TTTfs	p.F179fs	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Frame_Shift_Del_p.F161fs|TPTE_uc002yir.1_Frame_Shift_Del_p.F141fs|TPTE_uc010gkv.1_Frame_Shift_Del_p.F41fs	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179	Helical; (Potential).				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299			NA											7	316	---	---	---	---	NA	NA	NA	NA	NA