Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KANK4	163782	broad.mit.edu	37	1	62718834	62718834	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:62718834T>C	uc001dah.3	-	8	2964	c.2587A>G	c.(2587-2589)ATG>GTG	p.M863V	KANK4_uc001dai.3_Missense_Mutation_p.M235V|KANK4_uc001daf.3_Missense_Mutation_p.M1V|KANK4_uc001dag.3_Missense_Mutation_p.M219V	NM_181712	NP_859063	Q5T7N3	KANK4_HUMAN	ankyrin repeat domain 38	863	ANK 2.									ovary(3)|skin(2)|lung(1)	6						GGAGTGATCATTACGGCAGTG	0.522			NA											42	68					0	0	0.011902	0	0
LPAR3	23566	broad.mit.edu	37	1	85331206	85331206	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:85331206G>C	uc001dkl.2	-	1	637	c.598C>G	c.(598-600)CTC>GTC	p.L200V	LPAR3_uc009wcj.1_Missense_Mutation_p.L200V	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	200	Helical; Name=5; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						ACCATGATGAGGAAGGCCATG	0.537			NA											24	32					0	0	0.021523	0	0
CLCA2	9635	broad.mit.edu	37	1	86913287	86913287	+	Missense_Mutation	SNP	C	C	G	rs146994587		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:86913287C>G	uc001dlr.3	+	11	1972	c.1810C>G	c.(1810-1812)CCA>GCA	p.P604A		NM_006536	NP_006527	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2 precursor	604	Extracellular (Potential).				cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			ovary(1)|breast(1)|skin(1)	3		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		AGCTGTGCCCCCAGCCACTGT	0.498	Melanoma(157;1000 1898 5363 5664 48018)|Ovarian(88;135 1366 2838 28875 34642)		NA											47	66					0	0	0.01441	0	0
GBP4	115361	broad.mit.edu	37	1	89650951	89650951	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:89650951C>T	uc001dnb.2	-	11	2025	c.1909G>A	c.(1909-1911)GGC>AGC	p.G637S		NM_052941	NP_443173	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	637						cytoplasm	GTP binding|GTPase activity				0				all cancers(265;0.00723)|Epithelial(280;0.0291)		ATACGTGAGCCAAGATATTTT	0.348			NA											27	54					0	0	0.008361	0	0
RNPC3	55599	broad.mit.edu	37	1	104093592	104093592	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:104093592G>T	uc010oul.1	+	13	1506	c.1391G>T	c.(1390-1392)CGT>CTT	p.R464L	RNPC3_uc010oum.1_Missense_Mutation_p.R463L|RNPC3_uc010oun.1_Missense_Mutation_p.R464L|AMY2B_uc010ouo.1_RNA	NM_017619	NP_060089	Q96LT9	RBM40_HUMAN	RNA-binding region (RNP1, RRM) containing 3	464	RRM 2.				mRNA processing	U12-type spliceosomal complex	nucleotide binding|protein binding|RNA binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Lung(183;0.111)|Epithelial(280;0.122)|all cancers(265;0.125)|Colorectal(144;0.163)		AAAGAAGGTCGTATGAAAGGA	0.353			NA											18	38					5.35267e-07	9.28052e-07	0.007413	1	0
NGF	4803	broad.mit.edu	37	1	115829120	115829120	+	Silent	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:115829120G>A	uc001efu.1	-	3	466	c.297C>T	c.(295-297)GAC>GAT	p.D99D		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	99					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	GATCCTGAGTGTCTGCAGCTT	0.582			NA											11	25					0	0	0.013537	0	0
HRNR	388697	broad.mit.edu	37	1	152192466	152192466	+	Nonsense_Mutation	SNP	G	G	A	rs142288299		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:152192466G>A	uc001ezt.1	-	3	1715	c.1639C>T	c.(1639-1641)CGA>TGA	p.R547*		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	547	5.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GACTCATGTCGGCCACGGCTA	0.587			NA											16	342					0	0	0.024245	0	0
FCRL2	79368	broad.mit.edu	37	1	157740395	157740395	+	Silent	SNP	G	G	A	rs139205435		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:157740395G>A	uc001fre.2	-	3	173	c.114C>T	c.(112-114)TGC>TGT	p.C38C	FCRL2_uc001frd.2_5'Flank|FCRL2_uc010phz.1_Silent_p.C38C|FCRL2_uc009wsp.2_Silent_p.C38C|FCRL2_uc010pia.1_Silent_p.C38C	NM_030764	NP_110391	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2 precursor	38	Ig-like C2-type 1.|Extracellular (Potential).				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			ovary(1)|pancreas(1)	2	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GTTCTCCCTGGCATTTCAGAA	0.438			NA											14	69					0	0	0.016723	0	0
OR10K1	391109	broad.mit.edu	37	1	158436014	158436014	+	Silent	SNP	C	C	A	rs151132888	by1000genomes	TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:158436014C>A	uc010pij.1	+	1	663	c.663C>A	c.(661-663)ATC>ATA	p.I221I		NM_001004473	NP_001004473	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					ACATCCGCATCATCTCTGCCA	0.473			NA											45	140					1.61572e-30	3.74413e-30	0.010771	1	0
OR6K3	391114	broad.mit.edu	37	1	158687509	158687509	+	Missense_Mutation	SNP	G	G	T	rs144430951		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:158687509G>T	uc010pip.1	-	1	445	c.445C>A	c.(445-447)CAA>AAA	p.Q149K		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	149	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					ATGATCATTTGATAGCGAAGA	0.498			NA											30	127					3.73988e-18	7.3878e-18	0.00632	1	0
AIM2	9447	broad.mit.edu	37	1	159036024	159036024	+	Silent	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:159036024G>T	uc001ftj.1	-	4	737	c.492C>A	c.(490-492)CCC>CCA	p.P164P		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	164	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					CAAACGTGAAGGGCTTCTTTG	0.438			NA											114	82					2.5327e-61	5.98412e-61	0.01441	1	0
USP21	27005	broad.mit.edu	37	1	161130689	161130689	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:161130689G>A	uc010pke.1	+	3	636	c.259G>A	c.(259-261)GGG>AGG	p.G87R	USP21_uc010pkc.1_Missense_Mutation_p.G87R|USP21_uc010pkd.1_Missense_Mutation_p.G87R|USP21_uc010pkf.1_Missense_Mutation_p.G87R	NM_001014443	NP_001014443	Q9UK80	UBP21_HUMAN	ubiquitin-specific protease 21	87					histone deubiquitination|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	nucleus	metal ion binding|NEDD8-specific protease activity|protein binding|transcription coactivator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)|prostate(1)|breast(1)	5	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			AGCAGATCATGGGGTTCCCCT	0.637			NA											43	35					0	0	0.00874	0	0
ADCY10	55811	broad.mit.edu	37	1	167874234	167874234	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:167874234A>C	uc001ger.2	-	2	443	c.145T>G	c.(145-147)TCA>GCA	p.S49A	ADCY10_uc009wvk.2_5'UTR|ADCY10_uc010plj.1_Intron|ADCY10_uc009wvl.2_Missense_Mutation_p.S49A|ADCY10_uc009wvm.2_RNA	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	49	Guanylate cyclase 1.				intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CACTTGCCTGAAATATCAACA	0.448			NA											15	92					0	0	0.007413	0	0
KCNT2	343450	broad.mit.edu	37	1	196311313	196311313	+	Silent	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:196311313T>C	uc001gtd.1	-	15	1509	c.1449A>G	c.(1447-1449)AGA>AGG	p.R483R	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Intron|KCNT2_uc001gtf.1_Silent_p.R483R|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.R483R|KCNT2_uc001gth.1_Silent_p.R4R	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	483	Cytoplasmic (Potential).|RCK N-terminal.					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						TCCCGGAGCATCTACCGTACA	0.348			NA											69	48					0	0	0.01441	0	0
CNTN2	6900	broad.mit.edu	37	1	205031637	205031637	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:205031637C>T	uc001hbr.2	+	10	1449	c.1180C>T	c.(1180-1182)CAG>TAG	p.Q394*	CNTN2_uc001hbq.1_Nonsense_Mutation_p.Q285*|CNTN2_uc001hbs.2_Nonsense_Mutation_p.Q182*	NM_005076	NP_005067	Q02246	CNTN2_HUMAN	contactin 2 precursor	394	Ig-like C2-type 4.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			ovary(1)	1	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGGCATGTACCAGTGTGTGGC	0.622	Melanoma(183;2548 2817 37099 41192)		NA											19	91					0	0	0.008871	0	0
OR2W5	441932	broad.mit.edu	37	1	247654619	247654619	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:247654619G>A	uc001icz.1	+	1	190	c.190G>A	c.(190-192)GGG>AGG	p.G64R		NM_001004698	NP_001004698	A6NFC9	OR2W5_HUMAN	olfactory receptor, family 2, subfamily W,	64	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|skin(1)	3	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CTTCTTTCTTGGGAATCTGTC	0.522			NA											46	31					0	0	0.013114	0	0
FRMD4A	55691	broad.mit.edu	37	10	13735983	13735983	+	Silent	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr10:13735983C>A	uc001ims.2	-	15	1384	c.1032G>T	c.(1030-1032)ACG>ACT	p.T344T	FRMD4A_uc009xjf.1_Silent_p.T344T|FRMD4A_uc001imt.1_Silent_p.T377T|FRMD4A_uc001imu.1_Silent_p.T360T	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	344						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						TCAGCGTCCCCGTCTCGGTCA	0.582			NA											34	34					7.04047e-22	1.50155e-21	0.023175	1	0
STAM	8027	broad.mit.edu	37	10	17746987	17746987	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr10:17746987G>T	uc001ipj.1	+	11	1235	c.1019G>T	c.(1018-1020)GGA>GTA	p.G340V	STAM_uc009xjw.1_Intron	NM_003473	NP_003464	Q92783	STAM1_HUMAN	signal transducing adaptor molecule 1	340					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	SH3/SH2 adaptor activity			large_intestine(1)|ovary(1)	2						CACCAGATGGGACCTCTCATT	0.328			NA											29	80					1.99505e-19	4.0404e-19	0.012213	1	0
ANK3	288	broad.mit.edu	37	10	61946575	61946575	+	Silent	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr10:61946575G>A	uc001jky.2	-	17	2175	c.1983C>T	c.(1981-1983)ACC>ACT	p.T661T	ANK3_uc010qih.1_Silent_p.T644T|ANK3_uc001jkz.3_Silent_p.T655T|ANK3_uc001jlb.1_Silent_p.T190T|ANK3_uc001jlc.1_Silent_p.T322T	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	661					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						TTCCTTGCCGGGTAACTGCGT	0.522			NA											27	51					0	0	0.007291	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72434362	72434363	+	Missense_Mutation	DNP	AG	AG	TT			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	AG	AG	-	-	AG	AG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr10:72434362_72434363AG>TT	uc001jrh.2	+	2	133_134	c.133_134AG>TT	c.(133-135)AGC>TTC	p.S45F	ADAMTS14_uc001jrg.2_Missense_Mutation_p.S45F	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	45					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						AGTGCCCTGCAGCACAGACTTT	0.564			NA											29	45					0	0	0.004672	0	0
CHST3	9469	broad.mit.edu	37	10	73767095	73767095	+	Silent	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr10:73767095C>T	uc001jsn.2	+	3	746	c.306C>T	c.(304-306)GGC>GGT	p.G102G		NM_004273	NP_004264	Q7LGC8	CHST3_HUMAN	chondroitin 6-sulfotransferase 3	102	Lumenal (Potential).				chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity				0						TGCAGCTGGGCGTGGAGCCAG	0.652			NA											7	3					0	0	0.001984	0	0
SORCS3	22986	broad.mit.edu	37	10	106974237	106974237	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr10:106974237C>G	uc001kyi.1	+	18	2640	c.2413C>G	c.(2413-2415)CTA>GTA	p.L805V	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	805	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CACAGATGGGCTAAGGGAGAA	0.537	NSCLC(116;1497 1690 7108 13108 14106)		NA											26	41					0	0	0.024334	0	0
OR51B2	79345	broad.mit.edu	37	11	5344806	5344806	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:5344806G>C	uc001mao.1	-	1	777	c.722C>G	c.(721-723)TCC>TGC	p.S241C	HBG2_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033180	NP_149420	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B,	241	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTAATGTGGGAGATACAGGT	0.398			NA											23	45					0	0	0.012319	0	0
OR2D3	120775	broad.mit.edu	37	11	6942250	6942250	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:6942250G>T	uc010rav.1	+	1	18	c.18G>T	c.(16-18)TTG>TTT	p.L6F		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	6	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CTTTTTTCTTGTGCCAAACAG	0.398			NA											22	42					7.88262e-20	1.62369e-19	0.01892	1	0
TPH1	7166	broad.mit.edu	37	11	18048162	18048162	+	Silent	SNP	A	A	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:18048162A>T	uc001mnp.2	-	6	704	c.678T>A	c.(676-678)GGT>GGA	p.G226G	TPH1_uc009yhe.2_RNA	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	226					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	GGATGGAAAAACCTGTACGCT	0.418			NA											23	30					0	0	0.021523	0	0
OR4C15	81309	broad.mit.edu	37	11	55322011	55322011	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:55322011G>T	uc010rig.1	+	1	229	c.229G>T	c.(229-231)GAA>TAA	p.E77*		NM_001001920	NP_001001920	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C,	23	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						AAATGTTCAGGAAATAGTATT	0.418			NA								HNSCC(20;0.049)			58	88					3.21867e-24	7.24954e-24	0.01441	1	0
OR5T2	219464	broad.mit.edu	37	11	55999867	55999867	+	Silent	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:55999867C>T	uc010rjc.1	-	1	795	c.795G>A	c.(793-795)CTG>CTA	p.L265L		NM_001004746	NP_001004746	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T,	265	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					AATACATCTTCAGAATGGCCA	0.433			NA											49	85					0	0	0.01441	0	0
OR5T3	390154	broad.mit.edu	37	11	56020505	56020505	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:56020505G>T	uc010rjd.1	+	1	830	c.830G>T	c.(829-831)GGA>GTA	p.G277V		NM_001004747	NP_001004747	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T,	277	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Esophageal squamous(21;0.00448)					CACCTAACTGGAGTGACAATT	0.403			NA											54	98					6.4308e-24	1.42186e-23	0.01441	1	0
PDE2A	5138	broad.mit.edu	37	11	72291952	72291952	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr11:72291952T>C	uc010rrc.1	-	24	2354	c.2111A>G	c.(2110-2112)AAC>AGC	p.N704S	PDE2A_uc001oso.2_Missense_Mutation_p.N683S|PDE2A_uc010rra.1_Missense_Mutation_p.N697S|PDE2A_uc001osn.2_Missense_Mutation_p.N448S|PDE2A_uc010rrb.1_Missense_Mutation_p.N695S|PDE2A_uc010rrd.1_Missense_Mutation_p.N589S	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	704	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	GAAAGAGTTGTTTGTGCCTCT	0.532			NA											15	32					0	0	0.008871	0	0
KRT83	3889	broad.mit.edu	37	12	52710805	52710805	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr12:52710805C>A	uc001saf.2	-	5	816	c.753G>T	c.(751-753)GAG>GAT	p.E251D		NM_002282	NP_002273	P78385	KRT83_HUMAN	keratin 83	251	Rod.|Coil 1B.				epidermis development	keratin filament	structural molecule activity			skin(1)	1	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GAATGCGGATCTCCTGCAGGA	0.532	GBM(41;747 834 12702 24089 39393)|Esophageal Squamous(97;805 1414 12559 28198 31861)		NA											23	58					4.26978e-12	7.91551e-12	0.01892	1	0
NCKAP1L	3071	broad.mit.edu	37	12	54905735	54905735	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr12:54905735G>A	uc001sgc.3	+	9	866	c.787G>A	c.(787-789)GGG>AGG	p.G263R	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.G213R	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	263					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						ACCTACAGTTGGGTTTCTTCT	0.463			NA											37	62					0	0	0.023175	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37678501	37678501	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr13:37678501C>A	uc001uwm.1	-	1	1301	c.893G>T	c.(892-894)TGG>TTG	p.W298L		NM_145203	NP_660204	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	298					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)	1		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		TAACATCGTCCAATCAAATGT	0.498			NA											37	86					2.19358e-23	4.80593e-23	0.023175	1	0
PCDH17	27253	broad.mit.edu	37	13	58209093	58209093	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr13:58209093C>A	uc001vhq.1	+	1	3305	c.2413C>A	c.(2413-2415)CCC>ACC	p.P805T	PCDH17_uc010aec.1_Missense_Mutation_p.P805T	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	805	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GACCCGCCTGCCCCTCAGCTC	0.642	Melanoma(72;952 1291 1619 12849 33676)		NA											4	11					3.59834e-05	5.98068e-05	0.021553	1	0
SLC7A8	23428	broad.mit.edu	37	14	23598874	23598874	+	Silent	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr14:23598874G>A	uc001wiz.2	-	9	1974	c.1248C>T	c.(1246-1248)ATC>ATT	p.I416I	SLC7A8_uc001wiw.2_Silent_p.I33I|SLC7A8_uc001wix.2_Silent_p.I213I|SLC7A8_uc010tnk.1_Silent_p.I192I|SLC7A8_uc010tnl.1_Silent_p.I311I|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_Intron	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	416					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	TGGGGCGGGGGATATCAGGCT	0.493			NA											42	74					0	0	0.013114	0	0
ZBTB1	22890	broad.mit.edu	37	14	64989933	64989933	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr14:64989933G>C	uc001xhh.3	+	4	2142	c.1711G>C	c.(1711-1713)GAA>CAA	p.E571Q	ZBTB1_uc010aqg.2_Missense_Mutation_p.E571Q|ZBTB1_uc001xhi.2_Missense_Mutation_p.E571Q	NM_001123329	NP_001116801	Q9Y2K1	ZBTB1_HUMAN	zinc finger and BTB domain containing 1 isoform	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		all_lung(585;0.000567)|Myeloproliferative disorder(585;0.0255)|all_neural(303;0.0294)		UCEC - Uterine corpus endometrioid carcinoma (185;0.0182)|all cancers(60;3.78e-43)|OV - Ovarian serous cystadenocarcinoma(108;1.22e-20)|BRCA - Breast invasive adenocarcinoma(234;6.75e-06)|KIRC - Kidney renal clear cell carcinoma(182;0.00269)|STAD - Stomach adenocarcinoma(64;0.012)		GGAAGAAAATGAAAGAGATCA	0.358			NA											53	88					0	0	0.01441	0	0
CCDC88C	440193	broad.mit.edu	37	14	91772124	91772124	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr14:91772124C>A	uc010aty.2	-	19	3441	c.3342G>T	c.(3340-3342)CAG>CAT	p.Q1114H		NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	1114					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				GCTTGGCGGTCTGGGTCTGCA	0.597			NA											6	24					0.00116845	0.0018773	0.021553	1	0
ATP10A	57194	broad.mit.edu	37	15	25924557	25924557	+	Silent	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr15:25924557T>C	uc010ayu.2	-	21	4537	c.4431A>G	c.(4429-4431)TCA>TCG	p.S1477S		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	1477	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CTGATCGGCCTGAGTGGGGCT	0.532			NA											21	44					0	0	0.012319	0	0
GABRG3	2567	broad.mit.edu	37	15	27772650	27772650	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr15:27772650G>T	uc001zbg.1	+	8	1103	c.937G>T	c.(937-939)GTG>TTG	p.V313L		NM_033223	NP_150092	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma	313					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity				0		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		CGTGTCCTACGTGACCGCCAT	0.557	NSCLC(114;800 1656 7410 37729 45293)		NA											21	35					1.22574e-08	2.18817e-08	0.014323	1	0
SPTBN5	51332	broad.mit.edu	37	15	42168845	42168845	+	Silent	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr15:42168845C>A	uc001zos.2	-	20	4080	c.3747G>T	c.(3745-3747)ACG>ACT	p.T1249T		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1284	Spectrin 9.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCTCTCTGACCCTGGAGGGCG	0.677			NA											7	3					0.00307968	0.004851	0.00308	1	0
SMAD3	4088	broad.mit.edu	37	15	67473668	67473668	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr15:67473668G>T	uc002aqj.2	+	6	1046	c.748G>T	c.(748-750)GCC>TCC	p.A250S	SMAD3_uc010ujr.1_Missense_Mutation_p.A145S|SMAD3_uc010ujs.1_Missense_Mutation_p.A206S|SMAD3_uc010ujt.1_Missense_Mutation_p.A55S	NM_005902	NP_005893	P84022	SMAD3_HUMAN	mothers against decapentaplegic homolog 3	250	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			large_intestine(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		GACATTCCACGCCTCGCAGCC	0.592			NA											13	27					5.50884e-06	9.34951e-06	0.013537	1	0
DNAH3	55567	broad.mit.edu	37	16	20952726	20952726	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr16:20952726T>C	uc010vbe.1	-	59	11651	c.11651A>G	c.(11650-11652)AAC>AGC	p.N3884S	DNAH3_uc010vbd.1_Missense_Mutation_p.N1319S	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3884					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GGCCCACCTGTTGAATCTGAT	0.498			NA											146	295					0	0	0.01441	0	0
HSD3B7	80270	broad.mit.edu	37	16	30997441	30997441	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr16:30997441G>A	uc002eaf.2	+	3	344	c.238G>A	c.(238-240)GCC>ACC	p.A80T	HSD3B7_uc010cac.2_Missense_Mutation_p.A80T|HSD3B7_uc002eag.2_Missense_Mutation_p.A80T|HSD3B7_uc002eah.2_Missense_Mutation_p.A80T	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	80					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						TGTGGCCGGAGCCCATGTGGT	0.652			NA											4	16					0	0	0.009096	0	0
ITGAM	3684	broad.mit.edu	37	16	31341863	31341863	+	Missense_Mutation	SNP	G	G	T	rs140927329	by1000genomes	TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr16:31341863G>T	uc002ebq.2	+	28	3311	c.3213G>T	c.(3211-3213)GAG>GAT	p.E1071D	ITGAM_uc002ebr.2_Missense_Mutation_p.E1072D|ITGAM_uc010can.2_Missense_Mutation_p.E477D	NM_000632	NP_000623	P11215	ITAM_HUMAN	integrin alpha M isoform 2 precursor	1071	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			kidney(1)	1						GCACAGCTGAGATCTTGTTTA	0.612			NA											9	14					1.76689e-08	3.13104e-08	0.006214	1	0
ABCC11	85320	broad.mit.edu	37	16	48234330	48234330	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr16:48234330C>T	uc002eff.1	-	14	2289	c.1939G>A	c.(1939-1941)GCC>ACC	p.A647T	ABCC11_uc002efg.1_Missense_Mutation_p.A647T|ABCC11_uc002efh.1_Missense_Mutation_p.A647T|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	647	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GAATAGACGGCGCGGGCCAGG	0.582			NA							Cerumen_Type				13	28					0	0	0.013537	0	0
JPH3	57338	broad.mit.edu	37	16	87677922	87677922	+	Missense_Mutation	SNP	C	C	G	rs140115944	byFrequency	TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr16:87677922C>G	uc002fkd.2	+	2	695	c.441C>G	c.(439-441)AGC>AGG	p.S147R	JPH3_uc010vou.1_RNA	NM_020655	NP_065706	Q8WXH2	JPH3_HUMAN	junctophilin 3	147	MORN 6.|Cytoplasmic (Potential).				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane	protein binding			ovary(1)|pancreas(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0287)		TCCGGCAGAGCGTCCCGTATG	0.677			NA											26	46					0	0	0.01892	0	0
TUBB3	10381	broad.mit.edu	37	16	90001774	90001774	+	Silent	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr16:90001774G>T	uc002fph.1	+	4	980	c.915G>T	c.(913-915)CCG>CCT	p.P305P	TUBB3_uc002fpf.2_Silent_p.P652P|TUBB3_uc010ciz.1_Silent_p.P233P|TUBB3_uc002fpg.1_Silent_p.P159P|TUBB3_uc002fpi.1_Silent_p.P233P|TUBB3_uc002fpj.1_Silent_p.P233P|TUBB3_uc010cjb.1_Silent_p.P159P|TUBB3_uc002fpk.1_Silent_p.P159P	NM_006086	NP_006077	Q13509	TBB3_HUMAN	tubulin, beta, 4	305					'de novo' posttranslational protein folding|axon guidance|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(2)|pancreas(1)	3		all_cancers(9;1.69e-11)|Lung NSC(15;8.94e-06)|all_lung(18;1.39e-05)|all_neural(9;0.00581)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CCTGCGACCCGCGCCACGGCC	0.667			NA											33	69					4.65686e-17	9.05084e-17	0.017118	1	0
CAMKK1	84254	broad.mit.edu	37	17	3788921	3788922	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:3788921_3788922CC>AA	uc002fwt.2	-	2	154_155	c.60_61GG>TT	c.(58-63)GTGGCA>GTTTCA	p.A21S	CAMKK1_uc002fwu.2_Missense_Mutation_p.A21S|CAMKK1_uc002fwv.2_Missense_Mutation_p.A21S	NM_172206	NP_757343	Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase 1	21					synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TCGATGGCTGCCACCCGTTCTA	0.609			NA											12	31					0	0	0.004672	0	0
MYH2	4620	broad.mit.edu	37	17	10427914	10427914	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:10427914G>T	uc010coi.2	-	35	5172	c.5044C>A	c.(5044-5046)CGC>AGC	p.R1682S	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.R1682S|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1682	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TTGGCTCTGCGCTCCACCATG	0.567			NA											24	43					2.70639e-06	4.65886e-06	0.014323	1	0
MYOCD	93649	broad.mit.edu	37	17	12656348	12656348	+	Silent	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:12656348T>C	uc002gnn.2	+	10	2042	c.1743T>C	c.(1741-1743)TTT>TTC	p.F581F	MYOCD_uc002gno.2_Silent_p.F581F|MYOCD_uc002gnp.1_Silent_p.F485F|MYOCD_uc002gnq.2_Silent_p.F300F	NM_153604	NP_705832	Q8IZQ8	MYCD_HUMAN	myocardin isoform 2	581					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			central_nervous_system(2)|skin(2)|ovary(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		GCTGTCCTTTTGCATCCCAAG	0.512			NA											29	57					0	0	0.007291	0	0
Unknown	0	broad.mit.edu	37	17	21730899	21730899	+	Silent	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:21730899G>C	uc002gyy.3	+	2	326	c.201G>C	c.(199-201)CTG>CTC	p.L67L						SubName: Full=cDNA FLJ51326, highly similar to Homo sapiens ubiquitin B (UBB), mRNA;												NA						AGTCGACCCTGCATCTGGTCC	0.557			NA											16	42					0	0	0.024245	0	0
PSMD12	5718	broad.mit.edu	37	17	65337022	65337022	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:65337022C>T	uc002jfy.2	-	11	1394	c.1308G>A	c.(1306-1308)ATG>ATA	p.M436I	PSMD12_uc002jga.2_Missense_Mutation_p.M416I|PSMD12_uc002jfz.2_Missense_Mutation_p.M377I	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	436					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					TAACCAGAGACATTAATGAGT	0.343			NA											24	80					0	0	0.027356	0	0
FBF1	85302	broad.mit.edu	37	17	73915810	73915810	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:73915810G>A	uc002jqc.2	-	19	2306	c.2032C>T	c.(2032-2034)CGC>TGC	p.R678C	FBF1_uc002jqa.1_RNA|FBF1_uc010wsp.1_Missense_Mutation_p.R669C|FBF1_uc002jqd.1_Missense_Mutation_p.R679C|FBF1_uc002jqb.2_RNA|FBF1_uc010dgr.1_5'UTR	NM_001080542	NP_001074011	Q8TES7	FBF1_HUMAN	Fas (TNFRSF6) binding factor 1	678											0						GCCGCCAAGCGCCGCTGGTGC	0.672			NA											25	16					0	0	0.01892	0	0
MC2R	4158	broad.mit.edu	37	18	13885348	13885348	+	Missense_Mutation	SNP	G	G	T	rs140534585		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr18:13885348G>T	uc002ksp.1	-	2	347	c.170C>A	c.(169-171)GCA>GAA	p.A57E		NM_000529	NP_000520	Q01718	ACTHR_HUMAN	melanocortin 2 receptor	57	Cytoplasmic (By similarity).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	corticotropin receptor activity|protein binding			ovary(4)|skin(1)	5					Corticotropin(DB01285)|Cosyntropin(DB01284)	GTACATGGGTGCCTGGAGATT	0.418	Colon(141;1584 1782 35999 48227 48692)		NA											26	49					2.79863e-10	5.07121e-10	0.024334	1	0
WDR7	23335	broad.mit.edu	37	18	54688052	54688052	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr18:54688052A>G	uc002lgk.1	+	27	4452	c.4241A>G	c.(4240-4242)AAC>AGC	p.N1414S	WDR7_uc002lgl.1_Missense_Mutation_p.N1381S	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	1414	WD 9.									ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		ACCTACTCAAACACTGACAGC	0.428			NA											32	64					0	0	0.012213	0	0
ALPK2	115701	broad.mit.edu	37	18	56247275	56247275	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr18:56247275C>A	uc002lhj.3	-	4	947	c.733G>T	c.(733-735)GGT>TGT	p.G245C		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	245							ATP binding|protein serine/threonine kinase activity			ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						TTCAGGTCACCATCCGTGAAC	0.413			NA											61	130					1.1362e-29	2.60784e-29	0.01441	1	0
ZNRF4	148066	broad.mit.edu	37	19	5456253	5456253	+	Missense_Mutation	SNP	G	G	C	rs113345491		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:5456253G>C	uc002mca.3	+	1	828	c.751G>C	c.(751-753)GTG>CTG	p.V251L		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	251	Helical; (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		CTGTCACCCCGTGCTGACCGT	0.682			NA											23	17					0	0	0.016522	0	0
MUC16	94025	broad.mit.edu	37	19	9090468	9090468	+	Silent	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:9090468G>T	uc002mkp.2	-	1	1551	c.1347C>A	c.(1345-1347)TCC>TCA	p.S449S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	449	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CAGTCATTTCGGACTCTTCTC	0.488			NA											49	32					1.07234e-20	2.24726e-20	0.01441	1	0
KEAP1	9817	broad.mit.edu	37	19	10602581	10602581	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:10602581C>A	uc002moq.1	-	3	1153	c.997G>T	c.(997-999)GGC>TGC	p.G333C	KEAP1_uc002mop.1_Missense_Mutation_p.G51C|KEAP1_uc002mor.1_Missense_Mutation_p.G333C	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	333	Kelch 1.		G -> C (in a NSCLC cell line; strongly reduces interaction with NFE2L2 and reduces repression of NFE2L2-dependent gene expression).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGGAAGTAGCCGCCCGCGGTG	0.677			NA											9	7					2.17888e-05	3.64659e-05	0.006214	1	0
NFIX	4784	broad.mit.edu	37	19	13136190	13136190	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:13136190G>T	uc010xmx.1	+	2	460	c.407G>T	c.(406-408)CGG>CTG	p.R136L	NFIX_uc002mwd.2_Missense_Mutation_p.R128L|NFIX_uc002mwe.2_Missense_Mutation_p.R120L|NFIX_uc002mwf.2_Missense_Mutation_p.R131L|NFIX_uc002mwg.1_Missense_Mutation_p.R127L			Q14938	NFIX_HUMAN	RecName: Full=Nuclear factor 1;	128	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			breast(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(19;8.2e-22)			AAGGTGTGGCGGCTGGACCTG	0.617			NA											18	10					0.00229938	0.00364572	0.014323	1	0
ZNF536	9745	broad.mit.edu	37	19	31025796	31025796	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:31025796C>A	uc002nsu.1	+	3	2351	c.2213C>A	c.(2212-2214)CCA>CAA	p.P738Q	ZNF536_uc010edd.1_Missense_Mutation_p.P738Q	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	738					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GTCCAGCAACCAGCGCTGCTT	0.577			NA											48	91					2.24722e-20	4.66879e-20	0.01441	1	0
RYR1	6261	broad.mit.edu	37	19	38960061	38960061	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:38960061T>C	uc002oit.2	+	27	3803	c.3673T>C	c.(3673-3675)TTT>CTT	p.F1225L	RYR1_uc002oiu.2_Missense_Mutation_p.F1225L	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	1225	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTTCGAGCCATTTGCCATCAA	0.587			NA											46	89					0	0	0.01441	0	0
PRR12	57479	broad.mit.edu	37	19	50103069	50103069	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:50103069G>A	uc002poo.3	+	5	4219	c.4219G>A	c.(4219-4221)GAC>AAC	p.D1407N		NM_020719	NP_065770	Q9ULL5	PRR12_HUMAN	proline rich 12	586	Pro-rich.						DNA binding			central_nervous_system(1)|pancreas(1)	2		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		TGCCCTCGATGACCCACCCCT	0.662			NA											37	76					0	0	0.00874	0	0
TSKS	60385	broad.mit.edu	37	19	50266500	50266500	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:50266500G>T	uc002ppm.2	-	1	16	c.5C>A	c.(4-6)GCG>GAG	p.A2E		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	2							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CACCACGCTCGCCATGGTGTG	0.632			NA											12	47					4.93089e-13	9.43131e-13	0.020292	1	0
VN1R4	317703	broad.mit.edu	37	19	53770889	53770889	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:53770889C>A	uc010ydu.1	-	1	30	c.30G>T	c.(28-30)ATG>ATT	p.M10I		NM_173857	NP_776256	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	10	Helical; Name=1; (Potential).				response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.00294)		GTGATAAGATCATTCCCACTG	0.517			NA								HNSCC(26;0.072)			21	53					1.66031e-10	3.03131e-10	0.021523	1	0
NCR1	9437	broad.mit.edu	37	19	55417918	55417918	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:55417918T>A	uc002qib.2	+	3	146	c.108T>A	c.(106-108)CAT>CAA	p.H36Q	NCR1_uc002qic.2_Missense_Mutation_p.H36Q|NCR1_uc002qie.2_Missense_Mutation_p.H36Q|NCR1_uc002qid.2_Intron|NCR1_uc002qif.2_Intron|NCR1_uc010esj.2_Intron	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	36	Ig-like 1.|Extracellular (Potential).				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		CCGAGCCCCATTTCATGGTTC	0.547			NA											25	63					0	0	0.01892	0	0
TMEM150B	284417	broad.mit.edu	37	19	55831931	55831931	+	Silent	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:55831931G>A	uc010esw.1	-	4	296	c.123C>T	c.(121-123)TAC>TAT	p.Y41Y	TMEM150B_uc010yfu.1_Silent_p.Y41Y|TMEM150B_uc010yfv.1_RNA|TMEM150B_uc010yfw.1_RNA|TMEM150B_uc002qki.2_Silent_p.Y41Y	NM_001085488	NP_001078957	A6NC51	T150B_HUMAN	transmembrane protein 150B precursor	41	Extracellular (Potential).					integral to membrane					0						ATTACCTGATGTAGGGAAAGC	0.537			NA											34	64					0	0	0.027894	0	0
IL11	3589	broad.mit.edu	37	19	55879690	55879690	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr19:55879690C>T	uc002qks.1	-	4	453	c.317G>A	c.(316-318)CGG>CAG	p.R106Q	IL11_uc010yfx.1_Missense_Mutation_p.R27Q	NM_000641	NP_000632	P20809	IL11_HUMAN	interleukin 11 precursor	106					B cell differentiation|fat cell differentiation|megakaryocyte differentiation|negative regulation of hormone secretion|platelet activation|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity|growth factor activity|interleukin-11 receptor binding				0	Breast(117;0.191)	Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)	Oprelvekin(DB00038)	CTGCACGTGCCGCAGGTAGGA	0.687			NA											4	10					0	0	0.021553	0	0
IFT172	26160	broad.mit.edu	37	2	27700939	27700939	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr2:27700939C>T	uc002rku.2	-	11	1141	c.1090G>A	c.(1090-1092)GGA>AGA	p.G364R	IFT172_uc002rkw.2_Missense_Mutation_p.G364R|IFT172_uc010yls.1_Missense_Mutation_p.G343R|IFT172_uc010ezc.2_Missense_Mutation_p.G364R|IFT172_uc002rkv.2_Missense_Mutation_p.G338R	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	364					cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					CGTTCCTTTCCTAGGATTTTC	0.483			NA											77	196					0	0	0.01441	0	0
ARHGAP15	55843	broad.mit.edu	37	2	144245031	144245031	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr2:144245031C>G	uc002tvm.3	+	9	944	c.793C>G	c.(793-795)CTG>GTG	p.L265V	ARHGAP15_uc002tvn.2_Missense_Mutation_p.L31V	NM_018460	NP_060930	Q53QZ3	RHG15_HUMAN	ARHGAP15	265					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.151)		AAGACCTTCCCTGAAAACTCT	0.358			NA											95	76					0	0	0.01441	0	0
RBMS1	5937	broad.mit.edu	37	2	161137837	161137837	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr2:161137837A>C	uc002ubo.2	-	10	1383	c.939T>G	c.(937-939)ATT>ATG	p.I313M	RBMS1_uc002ubj.2_Missense_Mutation_p.I293M|RBMS1_uc002ubk.2_Missense_Mutation_p.I277M|RBMS1_uc002ubl.2_Missense_Mutation_p.I308M|RBMS1_uc002ubn.2_Missense_Mutation_p.I310M|RBMS1_uc002ubi.3_Missense_Mutation_p.I326M|RBMS1_uc002ubm.2_Missense_Mutation_p.I296M|RBMS1_uc002ubp.2_Missense_Mutation_p.I329M|RBMS1_uc010fox.2_3'UTR	NM_016836	NP_058520	P29558	RBMS1_HUMAN	RNA binding motif, single stranded interacting	313					DNA replication|RNA processing	nucleus	double-stranded DNA binding|nucleotide binding|protein binding|RNA binding|single-stranded DNA binding				0						GGTGCTGTAGAATATATGGTT	0.338			NA											55	64					0	0	0.01441	0	0
IKZF2	22807	broad.mit.edu	37	2	213872195	213872195	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr2:213872195C>A	uc002vem.2	-	8	1639	c.1470G>T	c.(1468-1470)ATG>ATT	p.M490I	IKZF2_uc010fuu.2_Missense_Mutation_p.M345I|IKZF2_uc002vej.2_Missense_Mutation_p.M437I|IKZF2_uc002vek.2_RNA|IKZF2_uc010fuv.2_Missense_Mutation_p.M416I|IKZF2_uc002vel.2_Missense_Mutation_p.M411I|IKZF2_uc010fuw.2_Missense_Mutation_p.M264I|IKZF2_uc010fux.2_Missense_Mutation_p.M264I|IKZF2_uc010fuy.2_Missense_Mutation_p.M418I|IKZF2_uc002ven.2_Missense_Mutation_p.M464I|IKZF2_uc002vei.2_Missense_Mutation_p.M268I	NM_016260	NP_057344	Q9UKS7	IKZF2_HUMAN	helios isoform 1	490	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CATGGCAACCCATGTGAATGG	0.498			NA											105	80					9.98844e-40	2.3371e-39	0.01441	1	0
ABCA12	26154	broad.mit.edu	37	2	215820069	215820069	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr2:215820069A>T	uc002vew.2	-	43	6470	c.6250T>A	c.(6250-6252)TGG>AGG	p.W2084R	ABCA12_uc002vev.2_Missense_Mutation_p.W1766R|ABCA12_uc010zjn.1_Missense_Mutation_p.W1011R	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	2084	Helical; (Potential).				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AAGTACATCCAGGAAAATGTT	0.313	Ovarian(66;664 1488 5121 34295)		NA											47	59					0	0	0.01441	0	0
SP100	6672	broad.mit.edu	37	2	231372747	231372747	+	Splice_Site	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr2:231372747G>T	uc002vqt.2	+	23	2193	c.2052_splice	c.e23+1	p.K684_splice	SP100_uc002vqs.2_Missense_Mutation_p.V685L|SP100_uc002vqu.1_Splice_Site_p.K684_splice|SP100_uc010fxp.1_Intron	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2						DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AAGAAAAAAGGTGATGATCAA	0.333			NA											32	44					1.60099e-16	3.0867e-16	0.021022	1	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768808	31768808	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr21:31768808G>C	uc002yoa.2	+	1	417	c.404G>C	c.(403-405)TGT>TCT	p.C135S		NM_181599	NP_853630	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	135						intermediate filament				ovary(1)	1						TATGGAGGCTGTGGCTTCCCT	0.577			NA											14	35					0	0	0.024245	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874303	31874303	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr21:31874303C>A	uc011ada.1	-	1	106	c.106G>T	c.(106-108)GGC>TGC	p.G36C		NM_181611	NP_853642	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	36						intermediate filament	protein binding				0						CCGCCATAGCCCAGTCTGCGG	0.587			NA											56	109					3.37043e-27	7.66296e-27	0.01441	1	0
IFNAR1	3454	broad.mit.edu	37	21	34721527	34721527	+	Missense_Mutation	SNP	G	G	A	rs17875833	byFrequency	TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr21:34721527G>A	uc002yrn.2	+	7	1066	c.919G>A	c.(919-921)GTA>ATA	p.V307I	IFNAR1_uc011adv.1_Missense_Mutation_p.V238I	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	307	Fibronectin type-III 2.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	CCTTCTCCGCGTACAAGCATC	0.348	Esophageal Squamous(73;817 1211 32990 35667 42746)		NA											29	72					0	0	0.007291	0	0
DSCAM	1826	broad.mit.edu	37	21	42080524	42080524	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr21:42080524G>T	uc002yyq.1	-	2	669	c.217C>A	c.(217-219)CGC>AGC	p.R73S	DSCAM_uc002yyr.1_RNA	NM_001389	NP_001380	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule isoform	73	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			ovary(6)|skin(4)|upper_aerodigestive_tract(1)	11		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACGTGGCGGATCCCGGGG	0.552	Melanoma(134;970 1778 1785 21664 32388)		NA											23	56					5.26018e-13	9.98191e-13	0.012319	1	0
TCF20	6942	broad.mit.edu	37	22	42575679	42575679	+	Silent	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr22:42575679G>T	uc003bcj.1	-	2	5819	c.5685C>A	c.(5683-5685)GCC>GCA	p.A1895A	TCF20_uc003bck.1_Silent_p.A1895A|TCF20_uc003bnt.2_Silent_p.A1895A	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1895	PHD-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						AGCCCAAGGTGGCGCCTGCCT	0.557			NA											49	85					3.4597e-24	7.72026e-24	0.01441	1	0
ZIC4	84107	broad.mit.edu	37	3	147108894	147108894	+	Silent	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr3:147108894C>A	uc003ewd.1	-	4	1101	c.828G>T	c.(826-828)ACG>ACT	p.T276T	ZIC4_uc003ewc.1_Silent_p.T206T|ZIC4_uc011bno.1_Silent_p.T326T	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	276	C2H2-type 5.					nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						AGCTGGGGTGCGTGTAGCACT	0.642			NA											7	27					0.000157383	0.00025979	0.00308	1	0
SMC4	10051	broad.mit.edu	37	3	160146643	160146643	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr3:160146643A>T	uc003fdh.2	+	18	2821	c.2708A>T	c.(2707-2709)CAA>CTA	p.Q903L	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.Q878L|SMC4_uc003fdj.2_Missense_Mutation_p.Q903L|SMC4_uc010hwd.2_Missense_Mutation_p.Q903L|SMC4_uc003fdl.2_Missense_Mutation_p.Q606L	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	903	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			AAGGCCCAACAAGACAAACTT	0.373			NA											30	39					0	0	0.009535	0	0
NCEH1	57552	broad.mit.edu	37	3	172353764	172353764	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr3:172353764C>A	uc011bpx.1	-	4	809	c.671G>T	c.(670-672)AGA>ATA	p.R224I	NCEH1_uc003fig.2_Missense_Mutation_p.R216I|NCEH1_uc011bpw.1_Missense_Mutation_p.R51I|NCEH1_uc011bpy.1_Missense_Mutation_p.R51I	NM_001146276	NP_001139748	Q6PIU2	NCEH1_HUMAN	arylacetamide deacetylase-like 1 isoform a	184	Lumenal (Potential).				lipid catabolic process	endoplasmic reticulum|integral to membrane|microsome	carboxylesterase activity				0						AATGCAAATTCTGCCTGGATC	0.468			NA											40	91					4.67007e-22	1.0049e-21	0.00874	1	0
EVC2	132884	broad.mit.edu	37	4	5696066	5696067	+	Missense_Mutation	DNP	CG	CG	AT	rs148388393		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr4:5696066_5696067CG>AT	uc003gij.2	-	3	499_500	c.445_446CG>AT	c.(445-447)CGC>ATC	p.R149I	EVC2_uc011bwb.1_5'UTR|EVC2_uc003gik.2_Missense_Mutation_p.R69I	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	limbin	149						integral to membrane				large_intestine(3)|ovary(2)	5						ACTTACCAGGCGGTGTGTTATA	0.391			NA											21	49					0	0	0.004672	0	0
ATP10D	57205	broad.mit.edu	37	4	47514700	47514700	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr4:47514700G>T	uc003gxk.1	+	2	307	c.143G>T	c.(142-144)GGA>GTA	p.G48V	ATP10D_uc003gxj.3_Missense_Mutation_p.G48V	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	48	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						AAACTGTCAGGAAGGCACCGG	0.507			NA											28	42					1.32181e-22	2.86987e-22	0.007291	1	0
PCDH10	57575	broad.mit.edu	37	4	134071419	134071419	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr4:134071419G>T	uc003iha.2	+	1	950	c.124G>T	c.(124-126)GGT>TGT	p.G42C	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.G42C	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	42	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		TGAAGATCTGGGTCTGGACAT	0.532			NA											33	83					1.99505e-19	4.0404e-19	0.012213	1	0
PLEKHG4B	153478	broad.mit.edu	37	5	163446	163446	+	Missense_Mutation	SNP	G	G	A	rs143360196		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:163446G>A	uc003jak.2	+	11	2241	c.2191G>A	c.(2191-2193)GAG>AAG	p.E731K		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	731					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GCAAAGTTTCGAGATACCTCA	0.572			NA											74	99					0	0	0.01441	0	0
PRDM9	56979	broad.mit.edu	37	5	23509089	23509089	+	Translation_Start_Site	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:23509089G>T	uc003jgo.2	+	2	129	c.-53G>T	c.(-55--51)CAGGG>CATGG			NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9						meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						GGGAGACTCAGGGCCCTTCTC	0.572			NA								HNSCC(3;0.000094)			16	13					6.31663e-08	1.10312e-07	0.024245	1	0
PDZD2	23037	broad.mit.edu	37	5	32059357	32059357	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:32059357G>A	uc003jhl.2	+	13	2601	c.2213G>A	c.(2212-2214)GGA>GAA	p.G738E	PDZD2_uc003jhm.2_Missense_Mutation_p.G738E|PDZD2_uc011cnx.1_Missense_Mutation_p.G564E	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	738	PDZ 4.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CCAAGAGTTGGATTAGGCATT	0.418			NA											16	38					0	0	0.00499	0	0
IQGAP2	10788	broad.mit.edu	37	5	75858378	75858378	+	Splice_Site	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:75858378G>A	uc003kek.2	+	3	525	c.303_splice	c.e3+1	p.K101_splice		NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACGTTATAAGGTAACCAAGAT	0.383			NA											60	50					0	0	0.01441	0	0
PSD2	84249	broad.mit.edu	37	5	139193133	139193133	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:139193133C>T	uc003leu.1	+	3	816	c.611C>T	c.(610-612)GCG>GTG	p.A204V		NM_032289	NP_115665	Q9BQI7	PSD2_HUMAN	pleckstrin and Sec7 domain containing 2	204					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGACATGGCGTTTGAGGGG	0.687			NA											28	33					0	0	0.009535	0	0
HARS2	23438	broad.mit.edu	37	5	140076937	140076937	+	Silent	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:140076937G>T	uc003lgx.2	+	10	1359	c.1143G>T	c.(1141-1143)GTG>GTT	p.V381V	HARS2_uc011czr.1_Silent_p.V356V|HARS2_uc011czs.1_Silent_p.V237V|HARS2_uc011czt.1_Silent_p.V209V|HARS2_uc011czu.1_Silent_p.V207V	NM_012208	NP_036340	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2 precursor	381					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCATGTGTGGGACTCAGCA	0.577			NA											12	61					3.07112e-06	5.24921e-06	0.010729	1	0
PCDHA3	56145	broad.mit.edu	37	5	140182996	140182996	+	Silent	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:140182996G>T	uc003lhf.2	+	1	2214	c.2214G>T	c.(2212-2214)ACG>ACT	p.T738T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA2_uc011czy.1_Intron|PCDHA3_uc011czz.1_Silent_p.T738T	NM_018906	NP_061729	Q9Y5H8	PCDA3_HUMAN	protocadherin alpha 3 isoform 1 precursor	738	Cytoplasmic (Potential).|6 X 4 AA repeats of P-X-X-P.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(6)|skin(2)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAAGCCCACGCTGGTGTGCT	0.652			NA											39	131					3.09479e-21	6.54249e-21	0.027894	1	0
PCDHB18	54660	broad.mit.edu	37	5	140615600	140615600	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:140615600C>G	uc003ljc.1	+	1	1663	c.1315C>G	c.(1315-1317)CCG>GCG	p.P439A		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						CTCGCTGCTGCCGCCCCAGGA	0.652			NA											58	223					0	0	0.01441	0	0
TIMD4	91937	broad.mit.edu	37	5	156375427	156375427	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:156375427C>A	uc003lwh.2	-	5	901	c.844G>T	c.(844-846)GCA>TCA	p.A282S	TIMD4_uc010jii.2_Intron	NM_138379	NP_612388	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain	282	Extracellular (Potential).					integral to membrane		p.A282E(1)		ovary(2)	2	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCCCCCCTACCTCCAGGCTGA	0.313			NA											19	17					1.56452e-12	2.92287e-12	0.007413	1	0
SLIT3	6586	broad.mit.edu	37	5	168096868	168096868	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:168096868T>C	uc003mab.2	-	35	4676	c.4256A>G	c.(4255-4257)CAT>CGT	p.H1419R	SLIT3_uc010jjg.2_Missense_Mutation_p.H1426R	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	1419	EGF-like 9.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCACTGCCCATGGTGACACTT	0.582	Ovarian(29;311 847 10864 17279 24903)		NA											15	42					0	0	0.028581	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179297292	179297292	+	Missense_Mutation	SNP	G	G	C	rs148980801	byFrequency	TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr5:179297292G>C	uc003mlh.2	-	16	2725	c.2688C>G	c.(2686-2688)GAC>GAG	p.D896E	TBC1D9B_uc003mli.2_Missense_Mutation_p.D896E|TBC1D9B_uc003mlj.2_Missense_Mutation_p.D896E|TBC1D9B_uc003mlg.2_Missense_Mutation_p.D72E|TBC1D9B_uc011dgv.1_Missense_Mutation_p.D72E|TBC1D9B_uc011dgw.1_Missense_Mutation_p.D72E|TBC1D9B_uc003mlk.1_Missense_Mutation_p.D54E	NM_198868	NP_942568	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	896	EF-hand.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(1)|skin(1)	2	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGATCAGCGAGTCCTTGTTTT	0.602			NA											6	149					0	0	0.001984	0	0
BTN2A2	10385	broad.mit.edu	37	6	26385353	26385353	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr6:26385353C>T	uc003nhq.2	+	3	291	c.205C>T	c.(205-207)CGG>TGG	p.R69W	BTN2A2_uc011dkf.1_Intron|BTN2A2_uc011dkg.1_Missense_Mutation_p.R69W|BTN2A2_uc003nhr.2_Intron|BTN2A2_uc011dkh.1_Intron|BTN2A2_uc003nhs.2_Missense_Mutation_p.R69W|BTN2A2_uc003nht.2_Missense_Mutation_p.R69W	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	69	Extracellular (Potential).|Ig-like V-type.				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						CATGGAGGTGCGGTGGTTCCG	0.547			NA											23	81					0	0	0.016522	0	0
CFB	629	broad.mit.edu	37	6	31914202	31914202	+	Silent	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr6:31914202G>C	uc003nyj.3	+	2	395	c.117G>C	c.(115-117)CTG>CTC	p.L39L	CFB_uc011dor.1_Silent_p.L541L|CFB_uc011dos.1_Silent_p.L39L|CFB_uc003nyi.2_Silent_p.L39L	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	39	Sushi 1.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CCTGCTCTCTGGAGGGGGTAG	0.597			NA											15	63					0	0	0.028581	0	0
KCNK16	83795	broad.mit.edu	37	6	39284685	39284685	+	Silent	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr6:39284685C>G	uc003ooq.2	-	4	548	c.534G>C	c.(532-534)CTG>CTC	p.L178L	KCNK17_uc003ooo.2_5'Flank|KCNK17_uc003oop.2_5'Flank|KCNK16_uc003oor.3_Silent_p.L178L|KCNK16_uc010jwy.2_Silent_p.L178L|KCNK16_uc011dtz.1_Silent_p.L178L	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	178	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						CCAGCGTCCCCAGGGTCAGGA	0.557			NA											32	105					0	0	0.012213	0	0
COL21A1	81578	broad.mit.edu	37	6	55990417	55990417	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr6:55990417C>A	uc003pcs.2	-	14	1830	c.1598G>T	c.(1597-1599)GGT>GTT	p.G533V	COL21A1_uc010jzz.2_5'Flank|COL21A1_uc011dxg.1_5'Flank|COL21A1_uc011dxh.1_5'Flank|COL21A1_uc003pct.1_RNA|COL21A1_uc011dxi.1_Missense_Mutation_p.G533V|COL21A1_uc003pcu.1_Missense_Mutation_p.G530V	NM_030820	NP_110447	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1 precursor	533					cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(2)	2	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACCCATTTCACCCTAAAAGAC	0.274			NA											7	13					1.12685e-05	1.8991e-05	0.004482	1	0
PRIM2	5558	broad.mit.edu	37	6	57512584	57512584	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr6:57512584C>A	uc003pdx.2	+	15	1499	c.1412C>A	c.(1411-1413)CCT>CAT	p.P471H		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	471					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		CCAGAAACTCCTCAACCCAAA	0.403			NA											17	377					0.000422831	0.00068853	0.028581	1	0
BMPER	168667	broad.mit.edu	37	7	34192754	34192754	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr7:34192754A>T	uc011kap.1	+	15	2041	c.1927A>T	c.(1927-1929)ATC>TTC	p.I643F		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	643	TIL.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						TCCGGGATGTATCAAGACGTG	0.502			NA											40	84					0	0	0.011902	0	0
ZNF479	90827	broad.mit.edu	37	7	57200007	57200007	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr7:57200007C>A	uc010kzo.2	-	2	296	c.25G>T	c.(25-27)GGA>TGA	p.G9*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	9					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCTCGGCTTCCAGGGGGTCCT	0.547			NA											23	42					1.17739e-12	2.21681e-12	0.027356	1	0
ANKIB1	54467	broad.mit.edu	37	7	91972523	91972523	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr7:91972523C>T	uc003ulw.2	+	6	1349	c.973C>T	c.(973-975)CCT>TCT	p.P325S		NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	325							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGCTTATCTCCTGGGGATTT	0.423			NA											16	23					0	0	0.028581	0	0
TRRAP	8295	broad.mit.edu	37	7	98535407	98535407	+	Silent	SNP	A	A	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr7:98535407A>G	uc003upp.2	+	30	4577	c.4368A>G	c.(4366-4368)CCA>CCG	p.P1456P	TRRAP_uc011kis.1_Silent_p.P1456P|TRRAP_uc003upr.2_Silent_p.P1148P	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	1456					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			GGCTCTTCCCAAATTCCTTCA	0.383			NA											16	22					0	0	0.00499	0	0
ZNF277	11179	broad.mit.edu	37	7	111977846	111977846	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr7:111977846G>A	uc003vge.2	+	9	1060	c.931G>A	c.(931-933)GCA>ACA	p.A311T	ZNF277_uc003vgf.2_Missense_Mutation_p.A233T|ZNF277_uc003vgg.2_Missense_Mutation_p.A136T	NM_021994	NP_068834	Q9NRM2	ZN277_HUMAN	zinc finger protein (C2H2 type) 277	311						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|breast(2)	4						TGAAAAGCAAGCAGAAACAAT	0.383			NA											22	62					0	0	0.01892	0	0
BRAF	673	broad.mit.edu	37	7	140481402	140481403	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr7:140481402_140481403CC>AA	uc003vwc.3	-	11	1466_1467	c.1405_1406GG>TT	c.(1405-1407)GGA>TTA	p.G469L		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	469	ATP (By similarity).|Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469A(19)|p.G469V(12)|p.G469S(6)|p.G469R(6)|p.G469E(5)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	GTAGACTGTTCCAAATGATCCA	0.371	Colon(40;35 892 2973 5743 27438)	G469A(NCIH1395_LUNG)|G469A(NCIH1755_LUNG)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				32	59					0	0	0.004672	0	0
SDR16C5	195814	broad.mit.edu	37	8	57228804	57228804	+	Missense_Mutation	SNP	G	G	A	rs116944947	by1000genomes	TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr8:57228804G>A	uc003xsy.1	-	2	741	c.103C>T	c.(103-105)CGG>TGG	p.R35W	SDR16C5_uc010lyk.1_Missense_Mutation_p.R35W|SDR16C5_uc010lyl.1_Missense_Mutation_p.R35W	NM_138969	NP_620419	Q8N3Y7	RDHE2_HUMAN	epidermal retinal dehydrogenase 2	35					detection of light stimulus involved in visual perception|keratinocyte proliferation|retinal metabolic process|retinol metabolic process	endoplasmic reticulum membrane|integral to membrane|integral to membrane of membrane fraction	binding|retinol dehydrogenase activity			ovary(1)|central_nervous_system(1)|skin(1)	3						ACGTTCTTCCGTGGCTTTGGG	0.458			NA											24	46					0	0	0.021523	0	0
TRPA1	8989	broad.mit.edu	37	8	72952008	72952008	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr8:72952008C>G	uc003xza.2	-	18	2261	c.2086G>C	c.(2086-2088)GAG>CAG	p.E696Q	uc011lff.1_Intron|uc003xyy.2_Intron	NM_007332	NP_015628	O75762	TRPA1_HUMAN	ankyrin-like protein 1	696	Cytoplasmic (Potential).					integral to plasma membrane				ovary(4)|lung(1)|kidney(1)	6			Epithelial(68;0.223)		Menthol(DB00825)	TTGAGAAGCTCTATGCGGTTA	0.299			NA											28	58					0	0	0.012213	0	0
PSKH2	85481	broad.mit.edu	37	8	87060816	87060816	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr8:87060816A>T	uc011lfy.1	-	3	1033	c.1033T>A	c.(1033-1035)TCT>ACT	p.S345T		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	345							ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			GAGTGGGGAGAGGCCCTCTGC	0.517			NA											34	58					0	0	0.017118	0	0
CSMD3	114788	broad.mit.edu	37	8	113314030	113314030	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr8:113314030C>G	uc003ynu.2	-	53	8591	c.8432G>C	c.(8431-8433)AGA>ACA	p.R2811T	CSMD3_uc003yns.2_Missense_Mutation_p.R2013T|CSMD3_uc003ynt.2_Missense_Mutation_p.R2771T|CSMD3_uc011lhx.1_Missense_Mutation_p.R2642T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2811	Extracellular (Potential).|Sushi 17.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ACCTAGGCATCTGGTTTCAGA	0.438			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	38					0	0	0.010504	0	0
ATAD2	29028	broad.mit.edu	37	8	124340444	124340444	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr8:124340444T>A	uc003yqh.3	-	25	3962	c.3854A>T	c.(3853-3855)GAA>GTA	p.E1285V	ATAD2_uc011lii.1_Missense_Mutation_p.E1076V|ATAD2_uc003yqi.3_RNA	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	1285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TCCTTCATTTTCATCAGAAAT	0.308			NA											12	21					0	0	0.010729	0	0
KIF24	347240	broad.mit.edu	37	9	34255920	34255920	+	Missense_Mutation	SNP	T	T	C	rs144702014		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr9:34255920T>C	uc003zua.3	-	11	3805	c.3685A>G	c.(3685-3687)AGG>GGG	p.R1229G	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	1229					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			CAACCAAGCCTTGTAGGATGT	0.532			NA									OREG0019148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	39					0	0	0.004672	0	0
MRPL50	54534	broad.mit.edu	37	9	104153117	104153117	+	Silent	SNP	T	T	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr9:104153117T>C	uc004bbe.2	-	2	153	c.108A>G	c.(106-108)CCA>CCG	p.P36P	MRPL50_uc011lvj.1_Silent_p.P36P	NM_019051	NP_061924	Q8N5N7	RM50_HUMAN	mitochondrial ribosomal protein L50	36						mitochondrion|ribosome					0		Acute lymphoblastic leukemia(62;0.0559)				CAACAACCACTGGCTCTTTCT	0.413			NA											38	45					0	0	0.021022	0	0
TLR4	7099	broad.mit.edu	37	9	120474686	120474686	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr9:120474686G>T	uc004bjz.2	+	3	571	c.280G>T	c.(280-282)GAA>TAA	p.E94*	TLR4_uc004bka.2_Nonsense_Mutation_p.E54*|TLR4_uc004bkb.2_5'UTR	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	94	LRR 2.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CCAGACAATTGAAGATGGGGC	0.388			NA											13	28					0.00185496	0.00296056	0.016723	1	0
CSF2RA	1438	broad.mit.edu	37	X	1419396	1419396	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chrX:1419396G>T	uc010nct.2	+	11	1145	c.823G>T	c.(823-825)GGT>TGT	p.G275C	CSF2RA_uc011mhb.1_Missense_Mutation_p.G275C|CSF2RA_uc004cpq.2_Intron|CSF2RA_uc004cpn.2_Missense_Mutation_p.G275C|CSF2RA_uc004cpo.2_Missense_Mutation_p.G275C|CSF2RA_uc010ncu.2_Intron|CSF2RA_uc011mhc.1_Missense_Mutation_p.G142C|CSF2RA_uc004cpp.2_Missense_Mutation_p.G275C|CSF2RA_uc010ncv.2_Missense_Mutation_p.G275C|CSF2RA_uc004cpr.2_Missense_Mutation_p.G275C	NM_001161529	NP_001155001	P15509	CSF2R_HUMAN	colony stimulating factor 2 receptor alpha chain	275	Extracellular (Potential).					extracellular region|integral to plasma membrane	cytokine receptor activity			ovary(2)	2		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	TAATGTTTCTGGTGATTTGGA	0.403	Esophageal Squamous(131;723 1707 25334 40494 41806)		NA											39	68					2.40579e-17	4.71379e-17	0.025465	1	0
GDPD2	54857	broad.mit.edu	37	X	69647191	69647191	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chrX:69647191G>C	uc004dyh.2	+	10	1065	c.814G>C	c.(814-816)GAT>CAT	p.D272H	GDPD2_uc010nkx.1_Intron|GDPD2_uc010nky.1_Missense_Mutation_p.D58H|GDPD2_uc011mpk.1_Missense_Mutation_p.D272H|GDPD2_uc011mpl.1_Missense_Mutation_p.D193H|GDPD2_uc011mpm.1_Missense_Mutation_p.D193H	NM_017711	NP_060181	Q9HCC8	GDPD2_HUMAN	osteoblast differentiation promoting factor	272	GDPD.|Extracellular (Potential).				glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			ovary(2)	2	Renal(35;0.156)					CCTCATGCATGATGAGCACCT	0.577			NA											10	7					0	0	0.006214	0	0
KDM5D	8284	broad.mit.edu	37	Y	21870790	21870790	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chrY:21870790C>G	uc004fug.2	-	21	3340	c.3052G>C	c.(3052-3054)GCT>CCT	p.A1018P	KDM5D_uc011naz.1_Missense_Mutation_p.A1049P|KDM5D_uc010nwy.2_Missense_Mutation_p.A961P|KDM5D_uc004fuf.2_Missense_Mutation_p.A193P	NM_004653	NP_004644	Q9BY66	KDM5D_HUMAN	jumonji, AT rich interactive domain 1D isoform	1018					chromatin modification|spermatogenesis	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			skin(1)	1					Vitamin C(DB00126)	GCAATCCAAGCTTGTGCCTTA	0.448			NA											20	11					0	0	0.01892	0	0
ZMYM1	79830	broad.mit.edu	37	1	35578842	35578842	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:35578842delA	uc001bym.2	+	11	1559	c.1411delA	c.(1411-1413)AAAfs	p.K471fs	ZMYM1_uc001byn.2_Frame_Shift_Del_p.K471fs|ZMYM1_uc010ohu.1_Frame_Shift_Del_p.K452fs|ZMYM1_uc001byo.2_Frame_Shift_Del_p.K111fs|ZMYM1_uc009vut.2_Frame_Shift_Del_p.K396fs	NM_024772	NP_079048	Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM domain containing 1	471	TTF-type.					nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GGAAAACAGTAAAAAAGATGT	0.343			NA											7	68	---	---	---	---	NA	NA	NA	NA	NA
KIAA0907	22889	broad.mit.edu	37	1	155886422	155886423	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	CT	CT	-	-	CT	CT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr1:155886422_155886423delCT	uc001fmi.1	-	12	1570_1571	c.1546_1547delAG	c.(1546-1548)AGGfs	p.R516fs	KIAA0907_uc001fmj.1_Frame_Shift_Del_p.R516fs|KIAA0907_uc009wrk.1_Frame_Shift_Del_p.R373fs|KIAA0907_uc009wrl.1_RNA	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	hypothetical protein LOC22889	516											0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TTACCTGTCCCTCTCTCTCTCT	0.396			NA											7	350	---	---	---	---	NA	NA	NA	NA	NA
ARID2	196528	broad.mit.edu	37	12	46215214	46215214	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr12:46215214delT	uc001ros.1	+	6	649	c.649delT	c.(649-651)TTTfs	p.F217fs	ARID2_uc001ror.2_Frame_Shift_Del_p.F217fs	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	217				F -> L (in Ref. 4; CAD91164).	chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TTTAGGATCCTTTTCCACTGT	0.259			NA											8	100	---	---	---	---	NA	NA	NA	NA	NA
ELL3	80237	broad.mit.edu	37	15	44066401	44066409	+	In_Frame_Del	DEL	CCGAACTCT	CCGAACTCT	-	rs147224616		TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	CCGAACTCT	CCGAACTCT	-	-	CCGAACTCT	CCGAACTCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr15:44066401_44066409delCCGAACTCT	uc001zsw.1	-	9	1412_1420	c.1009_1017delAGAGTTCGG	c.(1009-1017)AGAGTTCGGdel	p.RVR337del	ELL3_uc001zsv.1_In_Frame_Del_p.RVR291del|ELL3_uc001zsx.1_In_Frame_Del_p.RVR222del|uc001zsy.2_5'Flank	NM_025165	NP_079441	Q9HB65	ELL3_HUMAN	elongation factor RNA polymerase II-like 3	337_339					positive regulation of transcription elongation, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				ovary(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;7.81e-07)		GAGTTCCTCGCCGAACTCTTTTAATCTCT	0.502			NA											18	42	---	---	---	---	NA	NA	NA	NA	NA
CACNA1G	8913	broad.mit.edu	37	17	48653249	48653251	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	CAC	CAC	-	-	CAC	CAC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr17:48653249_48653251delCAC	uc002irk.1	+	8	1858_1860	c.1486_1488delCAC	c.(1486-1488)CACdel	p.H504del	CACNA1G_uc002iri.1_In_Frame_Del_p.H504del|CACNA1G_uc002irj.1_In_Frame_Del_p.H504del|CACNA1G_uc002irl.1_In_Frame_Del_p.H504del|CACNA1G_uc002irm.1_In_Frame_Del_p.H504del|CACNA1G_uc002irn.1_In_Frame_Del_p.H504del|CACNA1G_uc002iro.1_In_Frame_Del_p.H504del|CACNA1G_uc002irp.1_In_Frame_Del_p.H504del|CACNA1G_uc002irq.1_In_Frame_Del_p.H504del|CACNA1G_uc002irr.1_In_Frame_Del_p.H504del|CACNA1G_uc002irs.1_In_Frame_Del_p.H504del|CACNA1G_uc002irt.1_In_Frame_Del_p.H504del|CACNA1G_uc002irv.1_In_Frame_Del_p.H504del|CACNA1G_uc002irw.1_In_Frame_Del_p.H504del|CACNA1G_uc002iru.1_In_Frame_Del_p.H504del|CACNA1G_uc002irx.1_In_Frame_Del_p.H417del|CACNA1G_uc002iry.1_In_Frame_Del_p.H417del|CACNA1G_uc002irz.1_In_Frame_Del_p.H417del|CACNA1G_uc002isa.1_In_Frame_Del_p.H417del|CACNA1G_uc002isb.1_In_Frame_Del_p.H417del|CACNA1G_uc002isc.1_In_Frame_Del_p.H417del|CACNA1G_uc002isd.1_In_Frame_Del_p.H417del|CACNA1G_uc002ise.1_In_Frame_Del_p.H417del|CACNA1G_uc002isf.1_In_Frame_Del_p.H417del|CACNA1G_uc002isg.1_In_Frame_Del_p.H417del|CACNA1G_uc002ish.1_In_Frame_Del_p.H417del|CACNA1G_uc002isi.1_In_Frame_Del_p.H417del	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	504	Cytoplasmic (Potential).|Poly-His.				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCACCTGGTGcaccaccaccacc	0.596			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
NSUN7	79730	broad.mit.edu	37	4	40778252	40778253	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr4:40778252_40778253insT	uc003gvj.3	+	7	1507_1508	c.1012_1013insT	c.(1012-1014)CTTfs	p.L338fs	NSUN7_uc003gvi.3_Frame_Shift_Ins_p.L338fs	NM_024677	NP_078953			NOL1/NOP2/Sun domain family, member 7												0						CTTGAAGACCCTTTTCACAAAA	0.287			NA											32	72	---	---	---	---	NA	NA	NA	NA	NA
UBA6	55236	broad.mit.edu	37	4	68501182	68501182	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr4:68501182delA	uc003hdg.3	-	20	1883	c.1831delT	c.(1831-1833)TACfs	p.Y611fs	UBA6_uc003hdh.1_Frame_Shift_Del_p.Y137fs	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	611					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TGACTATTGTAAGACTCAGTC	0.323			NA											25	31	---	---	---	---	NA	NA	NA	NA	NA
ICK	22858	broad.mit.edu	37	6	52883129	52883129	+	Frame_Shift_Del	DEL	T	T	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr6:52883129delT	uc003pbh.2	-	8	1152	c.662delA	c.(661-663)AAGfs	p.K221fs	ICK_uc003pbi.2_Frame_Shift_Del_p.K221fs|ICK_uc003pbj.2_Frame_Shift_Del_p.K221fs	NM_016513	NP_057597	Q9UPZ9	ICK_HUMAN	intestinal cell kinase	221	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			ovary(1)|large_intestine(1)|lung(1)|kidney(1)|central_nervous_system(1)	5	Lung NSC(77;0.103)					TATCATTACCTTTTTTGGTGT	0.502			NA											7	325	---	---	---	---	NA	NA	NA	NA	NA
XKR4	114786	broad.mit.edu	37	8	56436672	56436672	+	Frame_Shift_Del	DEL	C	C	-			TCGA-78-7633-01A-11D-2063-08	TCGA-78-7633-10A-01D-2063-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	aea06070-5a30-4f58-8117-68f669dbe7bf	35b3b1be-aabe-461a-b26a-44c7c39542c3	g.chr8:56436672delC	uc003xsf.2	+	3	1871	c.1839delC	c.(1837-1839)GACfs	p.D613fs		NM_052898	NP_443130	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related	613						integral to membrane				pancreas(2)	2			Epithelial(17;0.000117)|all cancers(17;0.000836)			ATGTTTTGGACCGAAGCCTCC	0.478			NA											27	61	---	---	---	---	NA	NA	NA	NA	NA