Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DVL1	1855	broad.mit.edu	37	1	1273747	1273747	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:1273747T>A	uc001aer.3	-	13	1381	c.1334A>T	c.(1333-1335)TAC>TTC	p.Y445F	DVL1_uc002quu.2_Missense_Mutation_p.Y187F|DVL1_uc009vka.2_Missense_Mutation_p.Y128F|DVL1_uc001aeu.1_Missense_Mutation_p.Y204F	NM_004421	NP_004412	O14640	DVL1_HUMAN	dishevelled 1	470	DEP.				canonical Wnt receptor signaling pathway|dendrite morphogenesis|intracellular signal transduction|negative regulation of protein binding|negative regulation of protein kinase activity|neural tube development|neuromuscular junction development|neurotransmitter secretion|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway|protein localization to nucleus|receptor clustering|transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, planar cell polarity pathway	cytoplasmic membrane-bounded vesicle|cytosol|plasma membrane|synapse|synaptosome	frizzled binding|identical protein binding|protein kinase binding|signal transducer activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCTGCTGGCGTACTTCCGGGC	0.647			NA											18	23					0	0	0.007413	0	0
UTS2	10911	broad.mit.edu	37	1	7912998	7912998	+	Silent	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:7912998A>T	uc001aor.2	-	1	107	c.66T>A	c.(64-66)CCT>CCA	p.P22P	UTS2_uc001aoq.2_Silent_p.P22P|UTS2_uc001aos.2_Intron	NM_006786	NP_006777	O95399	UTS2_HUMAN	urotensin 2 isoform b preproprotein	22					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity				0	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		AGTCAAGGAGAGGAAGAGATA	0.393			NA											11	41					0	0	0.016723	0	0
IL22RA1	58985	broad.mit.edu	37	1	24460774	24460774	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:24460774C>G	uc001biq.1	-	4	497	c.458G>C	c.(457-459)CGG>CCG	p.R153P	IL22RA1_uc010oeg.1_Missense_Mutation_p.R45P|IL22RA1_uc009vrb.1_Missense_Mutation_p.R17P|IL22RA1_uc010oeh.1_Missense_Mutation_p.R153P	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	153	Extracellular (Potential).|Fibronectin type-III 2.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		CAGGGTTAGCCGGTGGCCATC	0.522			NA											18	38					0	0	0.012319	0	0
INADL	10207	broad.mit.edu	37	1	62613980	62613980	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:62613980G>T	uc001dab.2	+	42	5410	c.5296G>T	c.(5296-5298)GCC>TCC	p.A1766S	INADL_uc001dac.2_RNA|INADL_uc009wag.2_Missense_Mutation_p.A550S	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	1766					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						CAATATAAGCGCCATAGCAGC	0.383			NA											22	51					3.28513e-13	4.33805e-13	0.021523	1	0
DNASE2B	58511	broad.mit.edu	37	1	84880520	84880520	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:84880520G>A	uc001djt.1	+	6	1088	c.1055G>A	c.(1054-1056)GGA>GAA	p.G352E	DNASE2B_uc001dju.1_Missense_Mutation_p.G144E|DNASE2B_uc009wch.1_Missense_Mutation_p.G144E	NM_021233	NP_067056	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta isoform 1 precursor	352					DNA metabolic process	lysosome	deoxyribonuclease II activity				0				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		GCATTTCAAGGATTAGTATTA	0.393	Pancreas(54;788 1175 11852 16034 30034)		NA						Direct_reversal_of_damage					4	14					0	0	0.009096	0	0
OR6K3	391114	broad.mit.edu	37	1	158687501	158687501	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:158687501G>A	uc010pip.1	-	1	453	c.453C>T	c.(451-453)ATC>ATT	p.I151I		NM_001005327	NP_001005327	Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K,	151	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|kidney(1)|central_nervous_system(1)	3	all_hematologic(112;0.0378)					GGGGGGTCATGATCATTTGAT	0.498			NA											26	62					0	0	0.034045	0	0
PBX1	5087	broad.mit.edu	37	1	164768988	164768988	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:164768988G>T	uc001gct.2	+	4	821	c.563G>T	c.(562-564)CGG>CTG	p.R188L	PBX1_uc010pku.1_Missense_Mutation_p.R188L|PBX1_uc010pkv.1_Missense_Mutation_p.R105L|PBX1_uc001gcs.2_Missense_Mutation_p.R188L|PBX1_uc010pkw.1_Missense_Mutation_p.R78L	NM_002585	NP_002576	P40424	PBX1_HUMAN	pre-B-cell leukemia homeobox 1	188					negative regulation of sequence-specific DNA binding transcription factor activity|sex differentiation|steroid biosynthetic process	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription factor binding		EWSR1/PBX1(3)	soft_tissue(3)|lung(1)|skin(1)	5						GAGCAAAGCCGGACCAGGCCC	0.567			NA	T	TCF3|EWSR1	pre B-ALL|myoepithelioma								16	39					0.000566183	0.000589059	0.0333	1	0
SELL	6402	broad.mit.edu	37	1	169677576	169677577	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:169677576_169677577CC>AA	uc001ggk.2	-	3	651_652	c.453_454GG>TT	c.(451-456)AAGGCA>AATTCA	p.151_152KA>NS	C1orf112_uc001ggj.2_Intron|SELL_uc010pls.1_Missense_Mutation_p.104_105KA>NS|SELL_uc001ggl.1_Missense_Mutation_p.164_165KA>NS	NM_000655	NP_000646	P14151	LYAM1_HUMAN	selectin L precursor	151_152	C-type lectin.|Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	integral to plasma membrane	glycosphingolipid binding|heparin binding|protease binding|sugar binding				0	all_hematologic(923;0.208)					CAGAGGGCTGCCTTTAGTTTGT	0.49			NA											23	41					0	0	0.004672	0	0
CFHR2	3080	broad.mit.edu	37	1	196927176	196927176	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:196927176C>G	uc001gtq.1	+	4	663	c.586C>G	c.(586-588)CAA>GAA	p.Q196E	CFHR2_uc001gtr.1_Missense_Mutation_p.Q72E	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	196	Sushi 3.					extracellular region				skin(2)|ovary(1)	3						TAGAAACGGACAATGGTCAGA	0.368			NA											17	45					0	0	0.008871	0	0
PRELP	5549	broad.mit.edu	37	1	203452824	203452824	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:203452824G>T	uc001gzs.2	+	2	712	c.512G>T	c.(511-513)CGG>CTG	p.R171L	PRELP_uc001gzt.2_Missense_Mutation_p.R171L	NM_002725	NP_002716	P51888	PRELP_HUMAN	proline arginine-rich end leucine-rich repeat	171	LRR 4.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			ovary(1)|central_nervous_system(1)|pancreas(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCCCTGCCCCGGAACCTGGAG	0.597			NA											28	56					1.74807e-11	2.19575e-11	0.010818	1	0
ATP2B4	493	broad.mit.edu	37	1	203708726	203708726	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:203708726C>G	uc001gzw.2	+	21	4246	c.3362C>G	c.(3361-3363)CCC>CGC	p.P1121R	ATP2B4_uc001gzv.2_3'UTR|ATP2B4_uc001gzx.2_Missense_Mutation_p.P188R|ATP2B4_uc009xar.2_3'UTR	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1157	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			ATTCAGAAACCCTACAACCAA	0.483			NA											16	51					0	0	0.008871	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204415219	204415219	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:204415219G>A	uc001haw.2	-	17	3022	c.2543C>T	c.(2542-2544)TCG>TTG	p.S848L	PIK3C2B_uc010pqv.1_Missense_Mutation_p.S848L	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	848					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GCTCACCTCCGAGTGGCAGTA	0.622			NA									OREG0014135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	51					0	0	0.012213	0	0
ZNF670	93474	broad.mit.edu	37	1	247202725	247202725	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:247202725G>A	uc001icd.1	-	2	289	c.118C>T	c.(118-120)CTG>TTG	p.L40L	ZNF695_uc001ica.2_Intron|ZNF695_uc001icb.1_Intron	NM_033213	NP_149990	Q9BS34	ZN670_HUMAN	zinc finger protein 670	40	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			ACAGAAGCCAGGTTCCTGAAG	0.343			NA											16	33					0	0	0.008871	0	0
OR2M5	127059	broad.mit.edu	37	1	248308974	248308974	+	Silent	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:248308974C>A	uc010pze.1	+	1	525	c.525C>A	c.(523-525)GCC>GCA	p.A175A		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	175	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GGGAAATAGCCCACTTCTTCT	0.428			NA											53	174					3.45129e-13	4.49978e-13	0.01441	1	0
A1CF	29974	broad.mit.edu	37	10	52601733	52601733	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr10:52601733A>T	uc001jjj.2	-	5	442	c.254T>A	c.(253-255)ATG>AAG	p.M85K	A1CF_uc010qhn.1_Missense_Mutation_p.M93K|A1CF_uc001jji.2_Missense_Mutation_p.M85K|A1CF_uc001jjh.2_Missense_Mutation_p.M93K|A1CF_uc010qho.1_Missense_Mutation_p.M93K|A1CF_uc009xov.2_Missense_Mutation_p.M85K|A1CF_uc001jjk.1_Missense_Mutation_p.M85K	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	85	RRM 1.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CATCATTCTCATTTCATAAAT	0.284			NA											5	8					0	0	0.014758	0	0
KCNMA1	3778	broad.mit.edu	37	10	78771737	78771737	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr10:78771737C>A	uc001jxn.2	-	18	2257	c.2080G>T	c.(2080-2082)GGC>TGC	p.G694C	KCNMA1_uc001jxj.2_Missense_Mutation_p.G698C|KCNMA1_uc001jxk.1_Missense_Mutation_p.G309C|KCNMA1_uc009xrt.1_Missense_Mutation_p.G514C|KCNMA1_uc001jxl.1_Missense_Mutation_p.G348C|KCNMA1_uc001jxo.2_Missense_Mutation_p.G694C|KCNMA1_uc001jxm.2_Missense_Mutation_p.G694C|KCNMA1_uc001jxq.2_Missense_Mutation_p.G694C	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	694	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CGTTTGCAGCCACATTTTTTT	0.413			NA											8	29					0.00829132	0.0084555	0.008291	1	0
LGI1	9211	broad.mit.edu	37	10	95549922	95549922	+	Silent	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr10:95549922A>T	uc001kjc.3	+	5	834	c.498A>T	c.(496-498)ACA>ACT	p.T166T	LGI1_uc010qnv.1_Silent_p.T118T|LGI1_uc001kjd.3_Silent_p.T166T|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_RNA	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	166					axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				ATTCTTTAACAAATGTGTAAG	0.303			NA											5	11					0	0	0.02938	0	0
TCTN3	26123	broad.mit.edu	37	10	97442454	97442454	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr10:97442454T>A	uc001klb.3	-	12	1650	c.1406A>T	c.(1405-1407)CAG>CTG	p.Q469L	TCTN3_uc001kla.3_Missense_Mutation_p.Q313L|TCTN3_uc010qoi.1_Missense_Mutation_p.Q321L	NM_015631	NP_056446	Q6NUS6	TECT3_HUMAN	tectonic 3 isoform a precursor	469	Extracellular (Potential).				apoptosis	integral to membrane					0		Colorectal(252;0.0815)		Epithelial(162;1.69e-07)|all cancers(201;5.63e-06)		CCCTCCTTTCTGGGCTGGGTC	0.468			NA											44	90					0	0	0.01441	0	0
PDZD8	118987	broad.mit.edu	37	10	119043640	119043640	+	Silent	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr10:119043640C>T	uc001lde.1	-	5	2803	c.2604G>A	c.(2602-2604)CAG>CAA	p.Q868Q		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	868	Phorbol-ester/DAG-type.				intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		AAAACATACACTGGGAAGCTG	0.393			NA											14	35					0	0	0.007413	0	0
OR5AS1	219447	broad.mit.edu	37	11	55797982	55797982	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr11:55797982G>T	uc010riw.1	+	1	88	c.88G>T	c.(88-90)GTA>TTA	p.V30L		NM_001001921	NP_001001921	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|liver(1)|skin(1)	5	Esophageal squamous(21;0.00693)					ACTGTTCTTGGTATTCCTTCT	0.328			NA											7	17					3.09899e-07	3.54662e-07	0.004482	1	0
CPSF7	79869	broad.mit.edu	37	11	61183946	61183946	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr11:61183946T>A	uc001nrq.2	-	6	730	c.596A>T	c.(595-597)GAT>GTT	p.D199V	CPSF7_uc001nro.2_Missense_Mutation_p.D190V|CPSF7_uc001nrp.2_Missense_Mutation_p.D242V|CPSF7_uc001nrr.2_Missense_Mutation_p.D190V|CPSF7_uc001nrs.1_Missense_Mutation_p.D100V	NM_001136040	NP_001129512	Q8N684	CPSF7_HUMAN	pre-mRNA cleavage factor I, 59 kDa subunit	199					mRNA 3'-end processing|nuclear mRNA splicing, via spliceosome|protein tetramerization|termination of RNA polymerase II transcription	mRNA cleavage factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)	1						GGCCCGTCCATCAGCAGAATC	0.537			NA											49	104					0	0	0.01441	0	0
FADS3	3995	broad.mit.edu	37	11	61644995	61644995	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr11:61644995G>A	uc001nsm.2	-	7	1026	c.873C>T	c.(871-873)TGC>TGT	p.C291C	FADS3_uc001nsn.2_Silent_p.C167C	NM_021727	NP_068373	Q9Y5Q0	FADS3_HUMAN	fatty acid desaturase 3	291	Lumenal (Potential).				electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	heme binding|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water			ovary(1)|pancreas(1)	2						CCCACTGCATGCACACCAGCA	0.627			NA											18	45					0	0	0.014323	0	0
PCNXL3	399909	broad.mit.edu	37	11	65397824	65397824	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr11:65397824A>T	uc001oey.2	+	27	4219	c.4219A>T	c.(4219-4221)ACT>TCT	p.T1407S	PCNXL3_uc001oez.2_Missense_Mutation_p.T294S	NM_032223	NP_115599	Q9H6A9	PCX3_HUMAN	pecanex-like 3	1407						integral to membrane					0						CTCCACAGGCACTTACTGCCA	0.627			NA											10	27					0	0	0.010729	0	0
ODZ4	26011	broad.mit.edu	37	11	78380978	78380978	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr11:78380978C>T	uc001ozl.3	-	32	6875	c.6412G>A	c.(6412-6414)GTC>ATC	p.V2138I	ODZ4_uc001ozk.3_Missense_Mutation_p.V363I|ODZ4_uc009yvb.1_Missense_Mutation_p.V722I	NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	2138	Extracellular (Potential).|YD 15.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						TGGGTCATGACAGCTGTGGTG	0.453			NA											8	28					0	0	0.010729	0	0
KLHL1	57626	broad.mit.edu	37	13	70681634	70681634	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr13:70681634G>T	uc001vip.2	-	1	992	c.198C>A	c.(196-198)AGC>AGA	p.S66R	KLHL1_uc010thm.1_Missense_Mutation_p.S66R|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	66	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		TCCAGAAAGTGCTCACACCGC	0.448			NA											18	45					1.28384e-07	1.48579e-07	0.012319	1	0
LIG4	3981	broad.mit.edu	37	13	108862925	108862925	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr13:108862925G>A	uc001vqn.2	-	2	965	c.692C>T	c.(691-693)CCT>CTT	p.P231L	LIG4_uc001vqo.2_Missense_Mutation_p.P231L|LIG4_uc010agg.1_Missense_Mutation_p.P164L|LIG4_uc010agf.2_Missense_Mutation_p.P231L|LIG4_uc001vqp.2_Missense_Mutation_p.P231L	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	231					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					TCCTACAGAAGGATCATGCAG	0.363			NA						NHEJ					4	11					0	0	0.009096	0	0
MUDENG	55745	broad.mit.edu	37	14	57752960	57752960	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr14:57752960A>G	uc001xcv.2	+	7	1740	c.1313A>G	c.(1312-1314)GAT>GGT	p.D438G	MUDENG_uc010tri.1_Missense_Mutation_p.D192G|MUDENG_uc010trj.1_Missense_Mutation_p.D335G	NM_018229	NP_060699	Q9H0R1	MUDEN_HUMAN	Mu-2 related death-inducing protein	438	MHD.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex				ovary(1)	1						AGGATCTTAGATTACACACTT	0.338			NA											19	33					0	0	0.016522	0	0
YLPM1	56252	broad.mit.edu	37	14	75248810	75248810	+	Silent	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr14:75248810G>T	uc001xqj.3	+	4	2188	c.2064G>T	c.(2062-2064)CCG>CCT	p.P688P	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	493					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ACCATCCTCCGTTGCAATCAG	0.493			NA											12	25					4.3838e-07	4.90795e-07	0.016723	1	0
SLC24A4	123041	broad.mit.edu	37	14	92922777	92922777	+	Silent	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr14:92922777T>A	uc001yak.2	+	12	1053	c.1029T>A	c.(1027-1029)GGT>GGA	p.G343G	SLC24A4_uc001yai.2_Silent_p.G296G|SLC24A4_uc010twm.1_Silent_p.G341G|SLC24A4_uc001yaj.2_Silent_p.G324G|SLC24A4_uc010auj.2_Silent_p.G232G|SLC24A4_uc010twn.1_Silent_p.G116G|SLC24A4_uc001yan.2_Silent_p.G54G	NM_153646	NP_705932	Q8NFF2	NCKX4_HUMAN	solute carrier family 24 member 4 isoform 1	360	Extracellular (Potential).					integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(2)|ovary(1)	3		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		CGGCCAATGGTGTGAGCAGTA	0.527	NSCLC(10;315 435 10383 28450 38798)		NA									OREG0022876	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	32					0	0	0.006122	0	0
AHNAK2	113146	broad.mit.edu	37	14	105421945	105421945	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr14:105421945G>A	uc010axc.1	-	5	461	c.341C>T	c.(340-342)ACG>ATG	p.T114M	AHNAK2_uc001ypx.2_Missense_Mutation_p.T14M	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	114	PDZ.					nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TGTCTTCAGCGTCACCTCTGT	0.602			NA											35	54					0	0	0.010771	0	0
OCA2	4948	broad.mit.edu	37	15	28090122	28090122	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr15:28090122G>A	uc001zbh.3	-	23	2525	c.2415C>T	c.(2413-2415)TCC>TCT	p.S805S	OCA2_uc010ayv.2_Silent_p.S781S	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	805	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		ATTCCATGAAGGAGAACCCAT	0.358			NA							Oculocutaneous_Albinism				8	21					0	0	0.004482	0	0
ATP8B4	79895	broad.mit.edu	37	15	50215688	50215688	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr15:50215688C>T	uc001zxu.2	-	17	1788	c.1646G>A	c.(1645-1647)CGA>CAA	p.R549Q	ATP8B4_uc010ber.2_Missense_Mutation_p.R422Q|ATP8B4_uc010ufd.1_Missense_Mutation_p.R359Q|ATP8B4_uc010ufe.1_RNA	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	549	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TTCTGGGTTTCGAACTGAAAA	0.378			NA											6	11					0	0	0.038147	0	0
AP3B2	8120	broad.mit.edu	37	15	83331888	83331888	+	Silent	SNP	C	C	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr15:83331888C>G	uc010uoh.1	-	21	2715	c.2538G>C	c.(2536-2538)CTG>CTC	p.L846L	AP3B2_uc010uoi.1_Silent_p.L865L|AP3B2_uc010uoj.1_Silent_p.L814L|AP3B2_uc010bmp.2_5'Flank|AP3B2_uc010uog.1_Silent_p.L482L	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	846					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			CCGACGGTACCAGGGTGGAGT	0.632			NA											4	20					0	0	0.009096	0	0
KIAA0182	23199	broad.mit.edu	37	16	85682236	85682236	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr16:85682236G>T	uc002fix.2	+	3	379	c.305G>T	c.(304-306)CGC>CTC	p.R102L	KIAA0182_uc002fiw.2_5'UTR|KIAA0182_uc002fiy.2_Missense_Mutation_p.R29L	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	102							protein binding			large_intestine(3)|ovary(1)|skin(1)	5						ACACCCAAGCGCGTGCCCATG	0.677			NA											35	80					6.29468e-14	8.42016e-14	0.021022	1	0
YBX2	51087	broad.mit.edu	37	17	7194462	7194462	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr17:7194462T>A	uc002gfq.2	-	4	466	c.409A>T	c.(409-411)AGC>TGC	p.S137C		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	137	CSD.|Required for cytoplasmic retention (By similarity).				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						TCTCCAACGCTGCGCAGAAAC	0.502			NA											20	50					0	0	0.021523	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8219099	8219099	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr17:8219099T>G	uc002glc.2	+	8	1569	c.1448T>G	c.(1447-1449)GTG>GGG	p.V483G	ARHGEF15_uc002gld.2_Missense_Mutation_p.V483G|ARHGEF15_uc010vuw.1_Missense_Mutation_p.V372G	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	483	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						CTGTCCCGTGTGCGCTCTTCC	0.572			NA											13	31					0	0	0.028581	0	0
MYH3	4621	broad.mit.edu	37	17	10543512	10543512	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr17:10543512C>A	uc002gmq.1	-	21	2560	c.2483G>T	c.(2482-2484)TGG>TTG	p.W828L		NM_002470	NP_002461	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle,	828					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|central_nervous_system(2)|pancreas(1)	7						CATCCAGGGCCAGTGCTTGAC	0.458			NA											14	34					4.7546e-09	5.83005e-09	0.028581	1	0
KRTAP4-8	728224	broad.mit.edu	37	17	39253953	39253953	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr17:39253953G>T	uc010wfo.1	-	1	423	c.384C>A	c.(382-384)AGC>AGA	p.S128R		NM_031960	NP_114166	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4.8	128	21.|25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament					0						agatgctgcagctggggcggc	0.109			NA											3	17					5.18039e-06	5.67639e-06	0.038147	1	0
TANC2	26115	broad.mit.edu	37	17	61391778	61391778	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr17:61391778A>G	uc002jal.3	+	8	990	c.967A>G	c.(967-969)ATC>GTC	p.I323V	TANC2_uc010wpe.1_Missense_Mutation_p.I233V	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	323							binding			ovary(2)	2						GCCTCCAGATATCTCCTTGAA	0.428			NA											11	32					0	0	0.028581	0	0
C19orf21	126353	broad.mit.edu	37	19	757800	757800	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:757800C>G	uc002lpo.2	+	2	937	c.854C>G	c.(853-855)CCG>CGG	p.P285R		NM_173481	NP_775752	Q8IVT2	CS021_HUMAN	hypothetical protein LOC126353	285										upper_aerodigestive_tract(1)	1		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000145)|all_lung(49;0.000236)|Breast(49;0.0014)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGAGTCCCCGGGGACCCCC	0.657			NA											3	56					0	0	0.009096	0	0
ARRDC5	645432	broad.mit.edu	37	19	4902698	4902698	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:4902698C>T	uc002mbm.2	-	1	182	c.182G>A	c.(181-183)AGG>AAG	p.R61K		NM_001080523	NP_001073992	A6NEK1	ARRD5_HUMAN	arrestin domain containing 5	61					signal transduction						0				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0257)		GACGTAACCCCTTCCCACGAG	0.498			NA											8	113					0	0	0.004482	0	0
ZNF91	7644	broad.mit.edu	37	19	23543480	23543480	+	Silent	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:23543480C>T	uc002nre.2	-	4	2414	c.2301G>A	c.(2299-2301)GAG>GAA	p.E767E	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Silent_p.E735E	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	767						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TGAAGGGTTTCTCTCTAGTAT	0.373			NA											14	18					0	0	0.008871	0	0
LGI4	163175	broad.mit.edu	37	19	35617312	35617312	+	Silent	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:35617312G>T	uc002nxx.2	-	8	1755	c.1161C>A	c.(1159-1161)CCC>CCA	p.P387P	LGI4_uc002nxy.1_Silent_p.P215P|LGI4_uc002nxz.1_Silent_p.P215P	NM_139284	NP_644813	Q8N135	LGI4_HUMAN	leucine-rich repeat LGI family, member 4	387	EAR 2.					extracellular region				pancreas(1)	1	all_lung(56;7.56e-09)|Lung NSC(56;1.1e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.54e-20)|OV - Ovarian serous cystadenocarcinoma(14;1.33e-18)|all cancers(14;4.27e-17)|LUSC - Lung squamous cell carcinoma(66;0.0849)			GGAAGAGCACGGGCCGCTGGG	0.706			NA											7	13					1.06961e-07	1.25193e-07	0.038147	1	0
LTBP4	8425	broad.mit.edu	37	19	41115743	41115743	+	Silent	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:41115743C>T	uc002ooh.1	+	14	1851	c.1851C>T	c.(1849-1851)GGC>GGT	p.G617G	LTBP4_uc002oog.1_Silent_p.G580G|LTBP4_uc002ooi.1_Silent_p.G550G|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc010xvo.1_5'Flank|LTBP4_uc010ehb.1_5'Flank|LTBP4_uc002ook.1_5'Flank	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	617	Cys-rich.|EGF-like 4; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGGCCCGGGCTTCCGAGCCG	0.697			NA											5	10					0	0	0.014758	0	0
CRX	1406	broad.mit.edu	37	19	48342877	48342877	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:48342877T>C	uc002phq.3	+	4	757	c.553T>C	c.(553-555)TCT>CCT	p.S185P		NM_000554	NP_000545	O43186	CRX_HUMAN	cone-rod homeobox protein	185					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)	2		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		CTCAGGGCCGTCTCTGACCTC	0.672	Pancreas(57;461 1196 22201 40716 47188)		NA											9	29					0	0	0.004482	0	0
SLC17A7	57030	broad.mit.edu	37	19	49933995	49933995	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:49933995G>A	uc002pnp.2	-	12	1636	c.1464C>T	c.(1462-1464)GTC>GTT	p.V488V	SLC17A7_uc002pno.2_Silent_p.V150V	NM_020309	NP_064705	Q9P2U7	VGLU1_HUMAN	solute carrier family 17, member 7	488	Helical; (Potential).				glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			ovary(1)|pancreas(1)|skin(1)	3		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CAGAAGCAAAGACCCCGTAGA	0.582			NA											21	54					0	0	0.01892	0	0
ZNF761	388561	broad.mit.edu	37	19	53959831	53959831	+	Silent	SNP	T	T	C			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:53959831T>C	uc010eqp.2	+	7	2528	c.2070T>C	c.(2068-2070)TAT>TAC	p.Y690Y	ZNF761_uc010ydy.1_Silent_p.Y636Y|ZNF761_uc002qbt.1_Silent_p.Y636Y	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	690	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AGAAACCTTATAAGTGTAATG	0.393			NA											4	64					0	0	0.02938	0	0
ZNF329	79673	broad.mit.edu	37	19	58640680	58640680	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr19:58640680C>T	uc002qrn.2	-	4	428	c.191G>A	c.(190-192)TGT>TAT	p.C64Y	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	64					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		AGGATATTCACAAATTGCTTC	0.473			NA											8	34					0	0	0.004482	0	0
MEMO1	51072	broad.mit.edu	37	2	32117109	32117109	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:32117109C>A	uc002rnx.2	-	6	914	c.532G>T	c.(532-534)GCG>TCG	p.A178S	MEMO1_uc010ymu.1_Missense_Mutation_p.A155S|MEMO1_uc010ezq.2_Missense_Mutation_p.A178S|MEMO1_uc002rny.2_Intron|MEMO1_uc002rnz.2_RNA	NM_015955	NP_057039	Q9Y316	MEMO1_HUMAN	mediator of cell motility 1 isoform 1	178					regulation of microtubule-based process	cytosol|nucleus				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)					CTAGGATCCGCTAGATATTTA	0.363			NA											16	39					5.3912e-06	5.8452e-06	0.006122	1	0
BIRC6	57448	broad.mit.edu	37	2	32738056	32738056	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:32738056G>T	uc010ezu.2	+	54	10537	c.10403G>T	c.(10402-10404)AGA>ATA	p.R3468I		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	3468					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					GCTATGAAGAGAAGTGGCAGG	0.413	Pancreas(94;175 1509 16028 18060 45422)		NA											8	17					7.48243e-07	8.28699e-07	0.006214	1	0
DDX18	8886	broad.mit.edu	37	2	118586916	118586916	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:118586916G>A	uc002tlh.1	+	13	1843	c.1744G>A	c.(1744-1746)GCA>ACA	p.A582T		NM_006773	NP_006764	Q9NVP1	DDX18_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18	582							ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|ovary(1)|lung(1)	4						AGCCCAGGAAGCATATAAGTC	0.323			NA											3	53					0	0	0.02938	0	0
PTPN4	5775	broad.mit.edu	37	2	120639678	120639678	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:120639678C>T	uc002tmf.1	+	7	1190	c.419C>T	c.(418-420)CCC>CTC	p.P140L	PTPN4_uc010flj.1_5'UTR	NM_002830	NP_002821	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type	140	FERM.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			ovary(2)	2					Alendronate(DB00630)	ATTAGATTACCCTGTCCTTCT	0.333			NA											22	55					0	0	0.016522	0	0
LRP2	4036	broad.mit.edu	37	2	170002321	170002321	+	Silent	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:170002321C>T	uc002ues.2	-	70	13137	c.12924G>A	c.(12922-12924)ACG>ACA	p.T4308T		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4308	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TCACTACCAGCGTTTTCTCTT	0.388			NA											13	37					0	0	0.020292	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801342	185801342	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:185801342G>T	uc002uph.2	+	4	1813	c.1219G>T	c.(1219-1221)GTT>TTT	p.V407F		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	407						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TACTGAAGAGGTTAACATAAC	0.393			NA											14	19					3.27435e-08	3.87653e-08	0.020292	1	0
TRAK2	66008	broad.mit.edu	37	2	202252542	202252542	+	Missense_Mutation	SNP	G	G	A	rs142579315		TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:202252542G>A	uc002uyb.3	-	13	2026	c.1580C>T	c.(1579-1581)CCG>CTG	p.P527L		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	527				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						GCTCTCTGTCGGGGTGACACA	0.488			NA											35	56					0	0	0.017118	0	0
CHRNG	1146	broad.mit.edu	37	2	233408313	233408313	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr2:233408313G>A	uc002vsx.1	+	9	960	c.939G>A	c.(937-939)CTG>CTA	p.L313L	CHRNG_uc010fye.1_Silent_p.L261L	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	313	Helical; (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		CCTTCCTCCTGGTGGTGACCA	0.617			NA											13	25					0	0	0.028581	0	0
PLCB1	23236	broad.mit.edu	37	20	8737710	8737710	+	Silent	SNP	A	A	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr20:8737710A>G	uc002wnb.2	+	24	2544	c.2541A>G	c.(2539-2541)ACA>ACG	p.T847T	PLCB1_uc010zrb.1_Silent_p.T746T|PLCB1_uc002wna.2_Silent_p.T847T|PLCB1_uc002wnc.1_Silent_p.T746T|PLCB1_uc002wnd.1_Silent_p.T424T	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	847					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGGAGAAACACCATCAGAGG	0.433			NA											6	28					0	0	0.021553	0	0
MKKS	8195	broad.mit.edu	37	20	10389284	10389284	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr20:10389284C>A	uc002wnt.1	-	4	2040	c.1153G>T	c.(1153-1155)GAG>TAG	p.E385*	MKKS_uc002wnu.1_Nonsense_Mutation_p.E385*|MKKS_uc010zrd.1_RNA	NM_018848	NP_061336	Q9NPJ1	MKKS_HUMAN	McKusick-Kaufman syndrome protein	385					brain morphogenesis|cerebral cortex development|convergent extension involved in gastrulation|detection of mechanical stimulus involved in sensory perception of sound|fat cell differentiation|flagellum assembly|gonad development|heart looping|hippocampus development|intracellular transport|melanosome transport|photoreceptor cell maintenance|pigment granule aggregation in cell center|protein folding|regulation of cilium beat frequency involved in ciliary motility|sensory perception of smell|social behavior|spermatid development|striatum development	cytosol|microtubule organizing center|motile cilium	ATP binding|unfolded protein binding				0						ACCTTCAGCTCATCCCAGGCA	0.388	Melanoma(79;1979 2212 6640)		NA							Bardet-Biedl_syndrome				11	32					0.000151284	0.000159003	0.016723	1	0
ZNF341	84905	broad.mit.edu	37	20	32341111	32341111	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr20:32341111G>T	uc002wzy.2	+	5	643	c.623G>T	c.(622-624)GGG>GTG	p.G208V	ZNF341_uc002wzx.2_Missense_Mutation_p.G208V|ZNF341_uc010geq.2_Missense_Mutation_p.G118V|ZNF341_uc010ger.2_RNA	NM_032819	NP_116208	Q9BYN7	ZN341_HUMAN	zinc finger protein 341	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGCCCCCCTGGGCGTCCCAAC	0.443			NA											3	9					6.4e-05	6.79588e-05	0.004672	1	0
CHD6	84181	broad.mit.edu	37	20	40049350	40049350	+	Silent	SNP	G	G	A	rs113638490	byFrequency	TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr20:40049350G>A	uc002xka.1	-	31	6103	c.5925C>T	c.(5923-5925)ATC>ATT	p.I1975I		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1975					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				CCTCCATGGCGATAGTATTGG	0.438			NA											38	86					0	0	0.033182	0	0
ZNRF3	84133	broad.mit.edu	37	22	29446751	29446751	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr22:29446751C>T	uc003aeg.2	+	8	2447	c.2282C>T	c.(2281-2283)CCG>CTG	p.P761L	ZNRF3_uc003aeh.1_Missense_Mutation_p.P761L	NM_032173	NP_115549	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	861	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1						ACGCGAGGCCCGGATACCCCA	0.701			NA											5	9					0	0	0.014758	0	0
FOXRED2	80020	broad.mit.edu	37	22	36902321	36902321	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr22:36902321T>A	uc003apn.3	-	1	257	c.149A>T	c.(148-150)CAG>CTG	p.Q50L	FOXRED2_uc003apo.3_Missense_Mutation_p.Q50L|FOXRED2_uc003app.3_Missense_Mutation_p.Q50L	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	50					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						TCCAGCGCGCTGCAGGAAGTA	0.711			NA											7	11					0	0	0.038147	0	0
CHCHD4	131474	broad.mit.edu	37	3	14154427	14154427	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:14154427A>G	uc003byj.3	-	3	584	c.389T>C	c.(388-390)ATT>ACT	p.I130T	CHCHD4_uc003byi.3_Missense_Mutation_p.I143T	NM_001098502	NP_001091972	Q8N4Q1	MIA40_HUMAN	coiled-coil-helix-coiled-coil-helix domain	130					protein transport|transmembrane transport	mitochondrial intermembrane space					0						AGTGGCCTCAATGGGAGCTGT	0.363			NA											4	10					0	0	0.014758	0	0
MAP4	4134	broad.mit.edu	37	3	47958147	47958147	+	Silent	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:47958147C>T	uc003csb.2	-	7	1696	c.1170G>A	c.(1168-1170)TTG>TTA	p.L390L	MAP4_uc003csc.3_Silent_p.L390L|MAP4_uc011bbf.1_Silent_p.L367L|MAP4_uc003csf.3_Silent_p.L407L	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	390	17 X 14 AA tandem repeats.|26 residues 2.				negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		TGGAAGGAGCCAAGTCCATTT	0.448			NA											4	118					0	0	0.014758	0	0
PHF7	51533	broad.mit.edu	37	3	52448547	52448547	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:52448547G>T	uc003ddy.2	+	4	936	c.130G>T	c.(130-132)GAA>TAA	p.E44*	PHF7_uc003ddz.2_Nonsense_Mutation_p.E44*	NM_016483	NP_057567	Q9BWX1	PHF7_HUMAN	PHD finger protein 7 isoform 1	44						nucleus	zinc ion binding			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;1.71e-05)|Kidney(197;0.00178)|KIRC - Kidney renal clear cell carcinoma(197;0.00201)|OV - Ovarian serous cystadenocarcinoma(275;0.0275)		TGGGGATCCCGAAAAATTAGG	0.433			NA											21	72					5.26018e-13	6.77248e-13	0.012319	1	0
PIK3CA	5290	broad.mit.edu	37	3	178938934	178938934	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:178938934G>A	uc003fjk.2	+	14	2333	c.2176G>A	c.(2176-2178)GAA>AAA	p.E726K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	726					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E726K(2)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GAAGAAGGATGAAACACAAAA	0.363	Colon(199;1504 1750 3362 26421 31210 32040)		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			14	27					0	0	0.028581	0	0
ODZ3	55714	broad.mit.edu	37	4	183696138	183696138	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr4:183696138G>A	uc003ivd.1	+	23	5173	c.5136G>A	c.(5134-5136)CTG>CTA	p.L1712L		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1712	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CCAGTGGCCTGGACTCACACT	0.473			NA											3	17					0	0	0.004672	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140743981	140743981	+	Silent	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr5:140743981C>T	uc003lju.1	+	1	84	c.84C>T	c.(82-84)TCC>TCT	p.S28S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc011das.1_Silent_p.S28S	NM_018918	NP_061741	Q9Y5G8	PCDG5_HUMAN	protocadherin gamma subfamily A, 5 isoform 1	28					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCCAGGATCCGGGCAGATCC	0.657			NA											10	14					0	0	0.008291	0	0
SPRY4	81848	broad.mit.edu	37	5	141694060	141694060	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr5:141694060C>T	uc003lml.2	-	2	873	c.614G>A	c.(613-615)GGC>GAC	p.G205D	SPRY4_uc010jgi.1_Missense_Mutation_p.G228D	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	205	Cys-rich.|SPR.				multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTAGAAGATGCCCTGCACCAA	0.622			NA							Testicular_Cancer_Familial_Clustering_of				13	26					0	0	0.020292	0	0
ZFP57	346171	broad.mit.edu	37	6	29640660	29640660	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr6:29640660G>T	uc011dlw.1	-	4	1379	c.1228C>A	c.(1228-1230)CCG>ACG	p.P410T	ZFP57_uc003nnl.3_Missense_Mutation_p.P390T	NM_001109809	NP_001103279	Q9NU63	ZFP57_HUMAN	zinc finger protein 57 homolog	326					DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			ovary(3)|skin(2)	5						TAGTTGGGCGGCTCTGTGAGG	0.512			NA											15	148					3.32936e-07	3.7684e-07	0.006122	1	0
NOTCH4	4855	broad.mit.edu	37	6	32163539	32163539	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr6:32163539T>A	uc003obb.2	-	30	5826	c.5687A>T	c.(5686-5688)CAT>CTT	p.H1896L	GPSM3_uc003oax.3_5'Flank|GPSM3_uc003oay.3_5'Flank|GPSM3_uc003oaz.2_5'Flank|NOTCH4_uc011dpt.1_3'UTR|NOTCH4_uc003oba.2_Missense_Mutation_p.H556L|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1896	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						GCTCCGGCAATGAGAATAGGC	0.692			NA											9	29					0	0	0.004482	0	0
DST	667	broad.mit.edu	37	6	56351986	56351986	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr6:56351986A>T	uc003pdf.2	-	81	14634	c.14606T>A	c.(14605-14607)CTG>CAG	p.L4869Q	DST_uc003pcz.3_Missense_Mutation_p.L4691Q|DST_uc011dxj.1_Missense_Mutation_p.L4720Q|DST_uc011dxk.1_Missense_Mutation_p.L4731Q|DST_uc003pcy.3_Missense_Mutation_p.L4365Q|DST_uc003pda.3_Missense_Mutation_p.L61Q	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6777	Spectrin 18.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GTCATCAGCCAGGGAGGTTTT	0.423			NA											16	20					0	0	0.028581	0	0
ABCB5	340273	broad.mit.edu	37	7	20778661	20778661	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:20778661G>T	uc003suw.3	+	15	2134	c.1588G>T	c.(1588-1590)GCT>TCT	p.A530S	ABCB5_uc010kuh.2_Missense_Mutation_p.A975S	NM_178559	NP_848654	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B, member 5	530	Cytoplasmic (Potential).|ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			skin(2)|large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|pancreas(1)	6						GCTCGTTTTGGCTCCTGAATA	0.433			NA											14	16					1.67942e-08	2.01139e-08	0.006122	1	0
PHKG1	5260	broad.mit.edu	37	7	56155447	56155447	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:56155447G>C	uc003trz.1	-	3	301	c.106C>G	c.(106-108)CGA>GGA	p.R36G	PSPH_uc003trj.2_Intron|PHKG1_uc011kdb.1_Missense_Mutation_p.R36G|PHKG1_uc011kdc.1_Missense_Mutation_p.R36G|PHKG1_uc011kdd.1_5'UTR	NM_006213	NP_006204	Q16816	PHKG1_HUMAN	phosphorylase kinase gamma subunit 1	36	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			large_intestine(1)	1	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TGGATGCATCGCCTGACCACA	0.657	Melanoma(184;580 2064 5329 24177 35303)		NA											18	52					0	0	0.010504	0	0
TRRAP	8295	broad.mit.edu	37	7	98506438	98506438	+	Silent	SNP	C	C	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:98506438C>G	uc003upp.2	+	14	1412	c.1203C>G	c.(1201-1203)CTC>CTG	p.L401L	TRRAP_uc011kis.1_Silent_p.L401L|TRRAP_uc003upr.2_Silent_p.L93L	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	401					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCGTCCAGCTCTTCGCCAAGA	0.647			NA											5	7					0	0	0.021553	0	0
DOCK4	9732	broad.mit.edu	37	7	111462421	111462421	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:111462421T>C	uc003vfx.2	-	27	3196	c.2927A>G	c.(2926-2928)AAC>AGC	p.N976S	DOCK4_uc003vfw.2_Missense_Mutation_p.N417S|DOCK4_uc003vfy.2_Missense_Mutation_p.N1012S	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	976					cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				GTCTTACTTGTTAGCAACCAA	0.373			NA											6	18					0	0	0.02938	0	0
GPR85	54329	broad.mit.edu	37	7	112724502	112724502	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:112724502A>G	uc010ljv.2	-	2	792	c.275T>C	c.(274-276)CTG>CCG	p.L92P	GPR85_uc003vgp.1_Missense_Mutation_p.L92P|GPR85_uc003vgq.2_Missense_Mutation_p.L92P|GPR85_uc010ljw.1_Missense_Mutation_p.L92P	NM_001146266	NP_001139738	P60893	GPR85_HUMAN	G protein-coupled receptor 85	92	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)	2						TTTGCAAGTCAGAGTCCCATA	0.433			NA											21	46					0	0	0.027356	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:140453136A>T	uc003vwc.3	-	15	1860	c.1799T>A	c.(1798-1800)GTG>GAG	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	B-Raf	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(16892)|p.V600?(325)|p.V600K(176)|p.V600R(36)|p.V600M(25)|p.V600A(23)|p.V600D(21)|p.V600G(11)|p.V600_K601>E(8)|p.T599_V600insTT(3)|p.T599_R603>I(2)|p.T599_V600>IAL(2)|p.V600L(2)|p.T599_V600insT(2)|p.V600_W604del(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insV(1)|p.T599_V600insDFGLAT(1)	KIAA1549/BRAF(229)|AKAP9_ENST00000356239/BRAF(10)|AGTRAP/BRAF(2)|FCHSD1/BRAF(2)|SLC45A3/BRAF(2)	thyroid(8166)|large_intestine(5052)|skin(3798)|NS(368)|central_nervous_system(284)|ovary(236)|lung(78)|eye(53)|prostate(44)|endometrium(30)|biliary_tract(28)|soft_tissue(27)|haematopoietic_and_lymphoid_tissue(22)|breast(18)|upper_aerodigestive_tract(13)|stomach(13)|pancreas(10)|small_intestine(10)|testis(7)|bone(6)|cervix(5)|genital_tract(4)|oesophagus(3)|urinary_tract(3)|adrenal_gland(3)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|meninges(1)|kidney(1)|autonomic_ganglia(1)|pituitary(1)|salivary_gland(1)	18290	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368	Colon(40;35 892 2973 5743 27438)	V600E(UACC257_SKIN)|V600D(K029AX_SKIN)|V600E(HS695T_SKIN)|V600E(COLO679_SKIN)|V600E(BT474_BREAST)|V600E(IGR39_SKIN)|V600E(A101D_SKIN)|V600E(COLO783_SKIN)|V600E(IGR37_SKIN)|V600E(A375_SKIN)|V600E(WM793_SKIN)|V600E(COLO818_SKIN)|V600E(HS294T_SKIN)|V600E(SKMEL28_SKIN)|V600E(DU4475_BREAST)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(IGR1_SKIN)|V600E(SKHEP1_LIVER)|V600E(WM983B_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(RVH421_SKIN)|V600D(WM2664_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(SKMEL24_SKIN)|V600D(WM115_SKIN)|V600E(MALME3M_SKIN)|V600E(A673_BONE)|V600E(C32_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO800_SKIN)|V600E(COLO741_SKIN)|V600E(HS939T_SKIN)|V600E(COLO205_LARGE_INTESTINE)|V600E(K029AX_SKIN)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(SH4_SKIN)|V600E(WM88_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(COLO849_SKIN)|V600E(MELHO_SKIN)|V600E(BHT101_THYROID)|V600E(G361_SKIN)|V600E(UACC62_SKIN)|V600E(BCPAP_THYROID)|V600E(8505C_THYROID)|V600E(SW1417_LARGE_INTESTINE)|V600E(COLO829_SKIN)|V600E(RKO_LARGE_INTESTINE)|V600E(A2058_SKIN)|V600E(RPMI7951_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(SKMEL5_SKIN)|V600E(ES2_OVARY)|V600E(LOXIMVI_SKIN)	61	Mis|T|O	AKAP9|KIAA1549	melanoma|colorectal|papillary thyroid|borderline ov|Non small-cell lung cancer (NSCLC)|cholangiocarcinoma|pilocytic astrocytoma		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous_syndrome				13	25					0	0	0.0333	0	0
SSPO	23145	broad.mit.edu	37	7	149503054	149503054	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr7:149503054G>T	uc010lpk.2	+	59	8558	c.8558G>T	c.(8557-8559)CGT>CTT	p.R2853L		NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	2853	TSP type-1 8.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCCAGACACGTGGGCGCAGC	0.637			NA											9	24					0.00621372	0.00640013	0.006214	1	0
RP1L1	94137	broad.mit.edu	37	8	10469767	10469767	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr8:10469767C>A	uc003wtc.2	-	4	2070	c.1841G>T	c.(1840-1842)GGC>GTC	p.G614V		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	614					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		GCAGGAAAGGCCCAGAACCAG	0.622			NA											21	49					5.45024e-15	7.38651e-15	0.01892	1	0
NKX3-1	4824	broad.mit.edu	37	8	23538909	23538909	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr8:23538909T>C	uc011kzx.1	-	2	578	c.530A>G	c.(529-531)TAT>TGT	p.Y177C	NKX3-1_uc003xdv.1_Intron	NM_006167	NP_006158	Q99801	NKX31_HUMAN	NK3 homeobox 1	177	Homeobox.				negative regulation of estrogen receptor binding|negative regulation of transcription, DNA-dependent|positive regulation of cell division|positive regulation of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter	nucleus	estrogen receptor activity|estrogen receptor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region sequence-specific DNA binding				0		Prostate(55;0.114)		Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)|BRCA - Breast invasive adenocarcinoma(99;0.0708)		CTTAGTCTTATAGCGTCTGTT	0.582			NA											31	60					0	0	0.021022	0	0
KIAA1432	57589	broad.mit.edu	37	9	5753566	5753566	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr9:5753566A>T	uc003zji.2	+	13	1378	c.1285A>T	c.(1285-1287)ATT>TTT	p.I429F	KIAA1432_uc003zjh.2_Missense_Mutation_p.I429F|KIAA1432_uc003zjl.3_Intron|KIAA1432_uc003zjj.1_Intron	NM_020829	NP_065880	Q4ADV7	RIC1_HUMAN	connexin 43-interacting protein 150 isoform a	508						integral to membrane					0		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGGACAGAATATTGCTGTGGT	0.294			NA											12	16					0	0	0.0333	0	0
TMEM215	401498	broad.mit.edu	37	9	32784744	32784744	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr9:32784744A>C	uc003zri.3	+	2	928	c.563A>C	c.(562-564)GAG>GCG	p.E188A		NM_212558	NP_997723	Q68D42	TM215_HUMAN	transmembrane protein 215	188						integral to membrane					0						GACAGATCTGAGTGCCCTGAG	0.542			NA											22	35					0	0	0.021523	0	0
FOXD4L5	653427	broad.mit.edu	37	9	70177104	70177104	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr9:70177104C>A	uc010moc.2	-	1	1712	c.880G>T	c.(880-882)GCA>TCA	p.A294S		NM_001126334	NP_001119806	Q5VV16	FX4L5_HUMAN	forkhead box D4-like 5	294					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						GGGAAGGGTGCCGGGGTCGCC	0.662			NA											8	90					6.44725e-10	8.00081e-10	0.014323	1	0
IL3RA	3563	broad.mit.edu	37	X	1464277	1464277	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chrX:1464277A>G	uc004cps.2	+	3	482	c.133A>G	c.(133-135)AGA>GGA	p.R45G	IL3RA_uc011mhd.1_Intron	NM_002183	NP_002174	P26951	IL3RA_HUMAN	interleukin 3 receptor, alpha precursor	45	Extracellular (Potential).					integral to membrane|plasma membrane	interleukin-3 receptor activity			skin(2)|lung(1)	3		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)			Sargramostim(DB00020)	GGACCTTAACAGAAATGTGAC	0.383			NA											46	93					0	0	0.01441	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177720	89177720	+	Silent	SNP	C	C	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chrX:89177720C>A	uc004efe.2	+	2	685	c.636C>A	c.(634-636)GCC>GCA	p.A212A		NM_138960	NP_620410	Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	212						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2						AGGAGCACGCCGACTTCAGCA	0.527			NA											13	16					1.5842e-08	1.91968e-08	0.016723	1	0
MAGEC1	9947	broad.mit.edu	37	X	140994960	140994960	+	Silent	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chrX:140994960G>A	uc004fbt.2	+	4	2056	c.1770G>A	c.(1768-1770)CTG>CTA	p.L590L	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	590							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTGTCTCCTCACT	0.567			NA								HNSCC(15;0.026)			10	417					0	0	0.010729	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092402	151092402	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chrX:151092402G>A	uc004fez.2	+	3	422	c.266G>A	c.(265-267)AGC>AAC	p.S89N	MAGEA4_uc004ffa.2_Missense_Mutation_p.S89N|MAGEA4_uc004ffb.2_Missense_Mutation_p.S89N|MAGEA4_uc004ffc.2_Missense_Mutation_p.S89N|MAGEA4_uc004ffd.2_Missense_Mutation_p.S89N	NM_002362	NP_002353	P43358	MAGA4_HUMAN	melanoma antigen family A, 4	89							protein binding			ovary(1)|breast(1)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GAGGGTTCCAGCAGCCAAGAA	0.572			NA											24	41					0	0	0.027356	0	0
CAPN2	824	broad.mit.edu	37	1	223939704	223939713	+	Frame_Shift_Del	DEL	CAAGCTGGAA	CAAGCTGGAA	-			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	CAAGCTGGAA	CAAGCTGGAA	-	-	CAAGCTGGAA	CAAGCTGGAA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr1:223939704_223939713delCAAGCTGGAA	uc001hob.3	+	8	1129_1138	c.905_914delCAAGCTGGAA	c.(904-915)CCAAGCTGGAACfs	p.P302fs	CAPN2_uc010puy.1_Frame_Shift_Del_p.P224fs	NM_001748	NP_001739	P17655	CAN2_HUMAN	calpain 2 isoform 1	302_305	Calpain catalytic.				proteolysis	cytoplasm|plasma membrane				lung(3)|breast(1)|skin(1)	5				GBM - Glioblastoma multiforme(131;0.109)		TCCAGCTGCCCAAGCTGGAACACTATAGAC	0.514			NA											8	61	---	---	---	---	NA	NA	NA	NA	NA
PPP2R5B	5526	broad.mit.edu	37	11	64699334	64699334	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr11:64699334delT	uc001oby.2	+	11	1695	c.1110delT	c.(1108-1110)CATfs	p.H370fs	PPP2R5B_uc001obz.2_Frame_Shift_Del_p.H370fs	NM_006244	NP_006235	Q15173	2A5B_HUMAN	beta isoform of regulatory subunit B56, protein	370					signal transduction	cytoplasm|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(2)	2						CCAGCCCCCATTTCCAGGTAT	0.552			NA											30	66	---	---	---	---	NA	NA	NA	NA	NA
TXNRD1	7296	broad.mit.edu	37	12	104707093	104707093	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr12:104707093delG	uc010swk.1	+	6	630	c.608delG	c.(607-609)TGGfs	p.W203fs	TXNRD1_uc010swl.1_Frame_Shift_Del_p.W53fs|TXNRD1_uc010swm.1_Frame_Shift_Del_p.W105fs|TXNRD1_uc010swn.1_Frame_Shift_Del_p.W53fs|TXNRD1_uc010swo.1_Frame_Shift_Del_p.W53fs|TXNRD1_uc010swp.1_Frame_Shift_Del_p.W15fs|TXNRD1_uc010swq.1_Frame_Shift_Del_p.W103fs|TXNRD1_uc001tku.2_RNA|TXNRD1_uc009zun.2_Frame_Shift_Del_p.W119fs|TXNRD1_uc001tko.1_RNA|TXNRD1_uc001tkp.1_RNA	NM_001093771	NP_001087240	Q16881	TRXR1_HUMAN	thioredoxin reductase 1 isoform 3	203	FAD (By similarity).				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity				0						GGAACTAGATGGGGTAAGCTT	0.403	Ovarian(139;555 1836 9186 9946 10884)		NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
GRIN2C	2905	broad.mit.edu	37	17	72842339	72842344	+	In_Frame_Del	DEL	TTGCCT	TTGCCT	-			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	TTGCCT	TTGCCT	-	-	TTGCCT	TTGCCT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr17:72842339_72842344delTTGCCT	uc002jlt.1	-	11	2367_2372	c.2211_2216delAGGCAA	c.(2209-2217)GCAGGCAAG>GCG	p.GK738del	GRIN2C_uc010wrh.1_RNA|GRIN2C_uc002jlu.1_In_Frame_Del_p.GK738del	NM_000835	NP_000826	Q14957	NMDE3_HUMAN	N-methyl-D-aspartate receptor subunit 2C	738_739	Extracellular (Potential).				glutamate signaling pathway	cell junction|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|N-methyl-D-aspartate selective glutamate receptor activity			ovary(2)|breast(2)	4	all_lung(278;0.172)|Lung NSC(278;0.207)				Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)	GCCCTCGTCCTTGCCTGCCATGTAGT	0.597			NA											34	69	---	---	---	---	NA	NA	NA	NA	NA
SETD2	29072	broad.mit.edu	37	3	47098880	47098881	+	Frame_Shift_Ins	INS	-	-	T			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:47098880_47098881insT	uc003cqs.2	-	15	6446_6447	c.6393_6394insA	c.(6391-6396)CAACGGfs	p.Q2131fs	SETD2_uc003cqv.2_Frame_Shift_Ins_p.Q2198fs|SETD2_uc003cqt.1_RNA	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2131_2132	Potential.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.R1629fs*15(1)		kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGAGCCTCCCGTTGAGCCACCT	0.455			NA	N|F|S|Mis		clear cell renal carcinoma								28	88	---	---	---	---	NA	NA	NA	NA	NA
SETD2	29072	broad.mit.edu	37	3	47163361	47163361	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:47163361delT	uc003cqs.2	-	3	2818	c.2765delA	c.(2764-2766)AAGfs	p.K922fs	SETD2_uc003cqv.2_Frame_Shift_Del_p.K911fs	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	922					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		CCCTGCATGCTTTAAAAACTC	0.413			NA	N|F|S|Mis		clear cell renal carcinoma								22	43	---	---	---	---	NA	NA	NA	NA	NA
C3orf58	205428	broad.mit.edu	37	3	143691464	143691472	+	In_Frame_Del	DEL	GCGAGCCCC	GCGAGCCCC	-			TCGA-86-7714-01A-12D-2167-08	TCGA-86-7714-10A-01D-2167-08	GCGAGCCCC	GCGAGCCCC	-	-	GCGAGCCCC	GCGAGCCCC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	75da25e4-927d-4bf6-ba40-54ac5c109b3c	53d2a678-c2c3-46ac-9b69-9e29bb392037	g.chr3:143691464_143691472delGCGAGCCCC	uc003evo.2	+	1	825_833	c.290_298delGCGAGCCCC	c.(289-300)GGCGAGCCCCGC>GGC	p.EPR98del	C3orf58_uc011bnl.1_5'Flank	NM_173552	NP_775823	Q8NDZ4	CC058_HUMAN	hypothetical protein LOC205428 isoform a	98_100						COPI vesicle coat|extracellular region				ovary(1)	1						GCGCAGTACGGCGAGCCCCGCGAGGGCGG	0.708			NA											8	67	---	---	---	---	NA	NA	NA	NA	NA