Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TMC1	117531	broad.mit.edu	37	9	75435847	75435847	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:75435847G>T	ENST00000297784.5	+	20	2393	c.1853G>T	c.(1852-1854)tGc>tTc	p.C618F	TMC1_ENST00000396237.3_Missense_Mutation_p.C618F|TMC1_ENST00000340019.3_Missense_Mutation_p.C618F|TMC1_ENST00000486417.1_3'UTR	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	618					sensory perception of sound	integral to membrane		p.C618F(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						GCCGTTATGTGCTGCAATGTT	0.502000													10	133					0.000442599	0.000483143	1	1	0
HECW2	57520	broad.mit.edu	37	2	197298051	197298051	+	Missense_Mutation	SNP	C	C	T	rs151108819	byFrequency	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:197298051C>T	ENST00000260983.2	-	2	279	c.97G>A	c.(97-99)Gcc>Acc	p.A33T		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	33					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity	p.A33T(2)		biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						GAGCTCTGGGCGGCAAGGCTC	0.597000													9	46					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142264928	142264928	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:142264928T>G	ENST00000378004.3	+	5	805	c.450T>G	c.(448-450)aaT>aaG	p.N150K	ARHGAP26_ENST00000274498.4_Missense_Mutation_p.N150K	NM_001135608.1	NP_001129080.1	Q9UNA1	RHG26_HUMAN	Rho GTPase activating protein 26	150					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding	p.N150K(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AACACTTGAATTTGTCTTCCA	0.338000													10	43					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23793962	23793962	+	Nonsense_Mutation	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:23793962A>T	ENST00000354639.3	+	10	1557	c.1093A>T	c.(1093-1095)Aaa>Taa	p.K365*	STK31_ENST00000433467.2_Nonsense_Mutation_p.K388*|STK31_ENST00000428484.1_Nonsense_Mutation_p.K365*|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000355870.3_Nonsense_Mutation_p.K388*	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	388							ATP binding|nucleic acid binding|protein serine/threonine kinase activity	p.K388*(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						CCGTTTCGGAAAAGACCTTTC	0.368000													8	123					0	0	1	0	0
FAM178A	55719	broad.mit.edu	37	10	102678196	102678196	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:102678196C>T	ENST00000238961.3	+	4	1119	c.971C>T	c.(970-972)tCa>tTa	p.S324L	FAM178A_ENST00000370271.3_Missense_Mutation_p.S324L|FAM178A_ENST00000370269.3_Missense_Mutation_p.S324L	NM_018121.3	NP_060591.3	Q8IX21	F178A_HUMAN	family with sequence similarity 178, member A	324								p.S324L(1)									GAACCTACTTCAGGTAGAATC	0.299000													20	141					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725167	140725167	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:140725167G>A	ENST00000253812.6	+	1	1567	c.1567G>A	c.(1567-1569)Gag>Aag	p.E523K	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1												p.E523K(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTTCGACTACGAGCAATTTAG	0.562000													16	109					0	0	1	0	0
TMEM19	55266	broad.mit.edu	37	12	72091178	72091178	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:72091178C>A	ENST00000266673.5	+	4	1095	c.501C>A	c.(499-501)taC>taA	p.Y167*	TMEM19_ENST00000549735.1_Nonsense_Mutation_p.Y167*|RP11-293I14.2_ENST00000548802.1_3'UTR	NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	167						integral to membrane		p.Y167*(1)		large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CCAAGCAGTACTCCGCTTCCT	0.512000													19	85					2.32416e-17	3.19572e-17	1	1	0
RAB6C-AS1	100131320	broad.mit.edu	37	2	130725928	130725928	+	RNA	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:130725928T>A	ENST00000412425.1	-	0	690					NR_036537.1																						TAGCTGAGCCTGACCACTTGT	0.403000													4	63					0	0	1	0	0
LRRTM3	347731	broad.mit.edu	37	10	68687143	68687143	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:68687143C>A	ENST00000361320.4	+	2	1047	c.469C>A	c.(469-471)Cgg>Agg	p.R157R	CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron|CTNNA3_ENST00000494580.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	157						integral to membrane		p.R157R(2)		breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TCGGGGCTTGCGGAAGCTGCT	0.458000													16	115					3.32936e-07	4.13999e-07	1	1	0
RAB19	401409	broad.mit.edu	37	7	140110849	140110849	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:140110849G>T	ENST00000275874.5	+	3	476	c.278G>T	c.(277-279)tGg>tTg	p.W93L	RAB19_ENST00000537763.1_Intron|RAB19_ENST00000356407.3_Intron			A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	67					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding	p.W93L(1)		breast(3)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	9	Melanoma(164;0.0142)					CCCCAAATCTGGACCAAGTGA	0.502000													20	111					4.96729e-08	6.3993e-08	1	1	0
TMEM244	253582	broad.mit.edu	37	6	130164711	130164711	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:130164711T>G	ENST00000438392.1	-	4	337	c.157A>C	c.(157-159)Aaa>Caa	p.K53Q	TMEM244_ENST00000368143.1_Missense_Mutation_p.K53Q			Q5VVB8	CF191_HUMAN	transmembrane protein 244	53						integral to membrane		p.K53Q(1)									GGATTTGTTTTGAAATCAAAT	0.323000													4	119					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7691039	7691039	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:7691039C>T	ENST00000358368.4	-	5	677	c.640G>A	c.(640-642)Ggc>Agc	p.G214S	XAB2_ENST00000534844.1_Missense_Mutation_p.G211S	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	214					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding	p.G211S(1)		breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						TTGGACTTGCCGGCCTTAGAC	0.642000								Direct reversal of damage;Nucleotide excision repair (NER)					3	108					0	0	1	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629646	9629646	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:9629646G>T	ENST00000382492.2	-	1	817	c.499C>A	c.(499-501)Caa>Aaa	p.Q167K	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	167					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity	p.Q167K(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						TCTTCTTTTTGAATTGTGGCA	0.358000													5	52					3.59834e-05	4.18343e-05	1	1	0
TRBV25-1	28562	broad.mit.edu	37	7	142378624	142378624	+	RNA	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:142378624C>T	ENST00000390398.3	+	0	53																											TATCAGGCTCCTCTGCTACGT	0.468000													3	8					0	0	1	0	0
S1PR2	9294	broad.mit.edu	37	19	10334757	10334757	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:10334757G>A	ENST00000590320.1	-	2	935	c.825C>T	c.(823-825)gcC>gcT	p.A275A		NM_004230.3	NP_004221.3	O95136	S1PR2_HUMAN	sphingosine-1-phosphate receptor 2	275					activation of MAPK activity|positive regulation of cell proliferation	integral to membrane|plasma membrane	lipid binding|lysosphingolipid and lysophosphatidic acid receptor activity	p.A275A(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15						GGGTGGAGACGGCGAAAAAGT	0.632000													5	28					0	0	1	0	0
MSRB2	22921	broad.mit.edu	37	10	23408331	23408331	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:23408331G>T	ENST00000376510.3	+	4	498	c.395G>T	c.(394-396)cGt>cTt	p.R132L	MSRB2_ENST00000468633.1_3'UTR	NM_012228.3	NP_036360.3	Q9Y3D2	MSRB2_HUMAN	methionine sulfoxide reductase B2	132					protein repair	mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R132L(1)		endometrium(1)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	9					L-Methionine(DB00134)	ATCCTGAGACGTCTGGATACC	0.517000													8	73					0.00448238	0.00478344	1	1	0
ZNF486	90649	broad.mit.edu	37	19	20308637	20308637	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:20308637C>T	ENST00000335117.8	+	4	1175	c.1118C>T	c.(1117-1119)aCt>aTt	p.T373I	CTC-260E6.6_ENST00000585498.1_RNA|CTC-260E6.6_ENST00000586657.1_RNA|CTC-260E6.6_ENST00000593655.1_RNA	NM_052852.3	NP_443084.2	Q96H40	ZN486_HUMAN	zinc finger protein 486	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T373I(1)|p.T367I(1)		endometrium(3)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11						ATAATTCATACTGGAGAGAAA	0.433000													8	49					0	0	1	0	0
STRIP2	57464	broad.mit.edu	37	7	129125534	129125534	+	Missense_Mutation	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:129125534T>C	ENST00000249344.2	+	21	2409	c.2369T>C	c.(2368-2370)gTg>gCg	p.V790A		NM_020704.2	NP_065755.1			striatin interacting protein 2									p.V790A(1)									TTTTCACCTGTGGATAACTGC	0.502000													14	66					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89811676	89811676	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:89811676G>T	ENST00000310775.7	+	10	888	c.802G>T	c.(802-804)Gaa>Taa	p.E268*	FANCI_ENST00000300027.8_Nonsense_Mutation_p.E268*	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	268					cell cycle|DNA repair	nucleoplasm	protein binding	p.E268*(2)		breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TCGTCATGTGGAAGGCACCAT	0.418000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	150					8.10497e-08	1.03483e-07	1	1	0
STK11IP	114790	broad.mit.edu	37	2	220476447	220476447	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:220476447C>T	ENST00000456909.1	+	18	2316	c.2226C>T	c.(2224-2226)gcC>gcT	p.A742A	STK11IP_ENST00000295641.10_Silent_p.A753A			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	753					protein localization	cytoplasm	protein kinase binding	p.A753A(1)|p.A742A(1)		breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCCGTCTGCCAGCCCTGTCT	0.627000													4	49					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100679976	100679976	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:100679976C>A	ENST00000306151.4	+	3	5343	c.5279C>A	c.(5278-5280)cCg>cAg	p.P1760Q		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1760	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.P1760Q(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AGCACCACGCCGGTACTCAGT	0.507000													22	316					9.04412e-07	1.11492e-06	1	1	0
TPSAB1	7177	broad.mit.edu	37	16	1291244	1291244	+	Missense_Mutation	SNP	A	A	G	rs150845192		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:1291244A>G	ENST00000461509.2	+	2	367	c.173A>G	c.(172-174)cAc>cGc	p.H58R	TPSAB1_ENST00000338844.3_Missense_Mutation_p.H51R			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	51	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity	p.H51R(1)		NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				CTGAGAGTCCACGGCCCATAC	0.711000													5	71					0	0	1	0	0
NR6A1	2649	broad.mit.edu	37	9	127302372	127302372	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:127302372G>C	ENST00000487099.2	-	5	693	c.536C>G	c.(535-537)tCc>tGc	p.S179C	NR6A1_ENST00000344523.4_Missense_Mutation_p.S179C|NR6A1_ENST00000373584.3_Missense_Mutation_p.S175C|NR6A1_ENST00000416460.2_Missense_Mutation_p.S175C	NM_001278546.1	NP_001265475.1	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	179	Sufficient for interaction with UIMC1 (By similarity).				cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding	p.S179C(1)		NS(1)|breast(1)|cervix(1)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	17						GTTCCCAGGGGAACTGTGGTC	0.517000													18	93					0	0	1	0	0
CCNE1	898	broad.mit.edu	37	19	30312666	30312666	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:30312666T>A	ENST00000262643.3	+	8	926	c.647T>A	c.(646-648)gTg>gAg	p.V216E	CCNE1_ENST00000357943.5_Missense_Mutation_p.V173E|CCNE1_ENST00000444983.2_Missense_Mutation_p.V201E	NM_001238.2	NP_001229.1	P24864	CCNE1_HUMAN	cyclin E1	216					androgen receptor signaling pathway|cell division|positive regulation of transcription, DNA-dependent|regulation of cyclin-dependent protein kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle	cytosol|nucleoplasm	androgen receptor binding|protein kinase binding|transcription coactivator activity	p.V216E(1)		endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|skin(1)	20	all_cancers(1;2.19e-31)|all_epithelial(1;1.49e-30)|all_lung(1;1.37e-11)|Lung NSC(1;2.35e-11)|Ovarian(5;0.000902)|Breast(6;0.0203)|Esophageal squamous(110;0.195)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|Epithelial(1;6.85e-98)|all cancers(1;1.38e-94)|OV - Ovarian serous cystadenocarcinoma(1;1.38e-90)|STAD - Stomach adenocarcinoma(5;5.8e-07)|GBM - Glioblastoma multiforme(4;0.0394)|Lung(7;0.092)|LUAD - Lung adenocarcinoma(5;0.115)|BRCA - Breast invasive adenocarcinoma(6;0.183)|COAD - Colon adenocarcinoma(1;0.188)|Colorectal(1;0.202)			TTTGCGTATGTGACAGATGGA	0.388000			A		serous ovarian								6	55					0	0	1	0	0
TRIM50	135892	broad.mit.edu	37	7	72732960	72732960	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:72732960C>A	ENST00000333149.2	-	4	787	c.587G>T	c.(586-588)gGg>gTg	p.G196V	TRIM50_ENST00000453152.1_Missense_Mutation_p.G196V	NM_178125.2	NP_835226.1	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	196						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding	p.G196V(2)		endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						ACCCCCTATCCCCTCCAGGCA	0.667000													8	104					0.000274275	0.000304041	1	1	0
TRIM10	10107	broad.mit.edu	37	6	30128630	30128630	+	Silent	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:30128630G>T	ENST00000449742.2	-	1	81	c.6C>A	c.(4-6)gcC>gcA	p.A2A	TRIM10_ENST00000376704.3_Silent_p.A2A	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	2						cytoplasm	zinc ion binding	p.A2A(1)		ovary(1)	1						AGGCAGCAGAGGCCATGCTGG	0.602000													5	21					1.024e-07	1.29586e-07	1	1	0
CD1D	912	broad.mit.edu	37	1	158153922	158153922	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:158153922C>T	ENST00000368171.3	+	7	1489	c.990C>T	c.(988-990)tcC>tcT	p.S330S		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	330					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding	p.S330S(1)		endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CTCACAGTTCCTATCAGGGCG	0.517000													3	110					0	0	1	0	0
CACNG4	27092	broad.mit.edu	37	17	65021068	65021068	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:65021068C>A	ENST00000262138.3	+	3	399	c.397C>A	c.(397-399)Cgc>Agc	p.R133S		NM_014405.3	NP_055220.1	Q9UBN1	CCG4_HUMAN	calcium channel, voltage-dependent, gamma subunit 4	133					membrane depolarization|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane	voltage-gated calcium channel activity	p.R133S(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(3)	19	all_cancers(12;9.86e-11)		BRCA - Breast invasive adenocarcinoma(6;1.35e-07)			GATCTACAGCCGCAAGAACAA	0.672000													4	75					0.000602214	0.000652399	1	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	53					0	0	1	0	0
DNAJC4	3338	broad.mit.edu	37	11	63999376	63999376	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:63999376G>A	ENST00000321685.3	+	3	585	c.120G>A	c.(118-120)ggG>ggA	p.G40G	RP11-783K16.14_ENST00000534988.1_RNA|DNAJC4_ENST00000321460.5_Silent_p.G40G|DNAJC4_ENST00000355040.4_Silent_p.G40G|RP11-783K16.14_ENST00000539963.1_RNA	NM_005528.3	NP_005519.2	Q9NNZ3	DNJC4_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 4	40	J.				protein folding|response to unfolded protein	integral to membrane|membrane fraction	heat shock protein binding|unfolded protein binding	p.G40G(1)		endometrium(1)|lung(1)|prostate(1)	3						AACTGTTGGGGGTGCATCCTG	0.552000													7	55					0	0	1	0	0
CTSE	1510	broad.mit.edu	37	1	206325297	206325297	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:206325297G>A	ENST00000361052.3	+	5	655	c.537G>A	c.(535-537)caG>caA	p.Q179Q	CTSE_ENST00000360218.2_Silent_p.Q174Q|CTSE_ENST00000432969.2_Silent_p.Q99Q|CTSE_ENST00000468617.1_3'UTR|CTSE_ENST00000358184.2_Silent_p.Q174Q			P14091	CATE_HUMAN	cathepsin E	179					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity	p.Q174Q(2)		endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			AGCCAGGCCAGACCTTTGTGG	0.532000													3	57					0	0	1	0	0
ABCD2	225	broad.mit.edu	37	12	39947886	39947886	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:39947886C>T	ENST00000308666.3	-	10	2186	c.2051G>A	c.(2050-2052)cGc>cAc	p.R684H		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	684	ABC transporter.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding	p.R684H(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						TTGTTCAAAGCGCCAACCTCC	0.348000													6	84					0	0	1	0	0
TMEM234	56063	broad.mit.edu	37	1	32682936	32682936	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:32682936C>A	ENST00000373593.1	-	4	272	c.252G>T	c.(250-252)gtG>gtT	p.V84V	TMEM234_ENST00000344461.3_Silent_p.V84V|TMEM234_ENST00000309777.6_Silent_p.V84V|TMEM234_ENST00000485689.1_5'UTR|TMEM234_ENST00000545122.1_Silent_p.V84V			Q8WY98	TM234_HUMAN	transmembrane protein 234	84						integral to membrane		p.V84V(1)		kidney(2)|lung(3)	5						TACAGATGGGCACAGCCAGGG	0.453000													7	66					0.000157383	0.000177211	1	1	0
ZNF155	7711	broad.mit.edu	37	19	44495759	44495759	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:44495759G>A	ENST00000270014.2	+	3	203	c.75G>A	c.(73-75)ctG>ctA	p.L25L	ZNF155_ENST00000590615.1_Silent_p.L25L|ZNF155_ENST00000407951.2_Silent_p.L36L	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	25	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D26N(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				TGGGGCTGCTGGACCCTGCCC	0.517000													54	180					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39552755	39552755	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:39552755G>C	ENST00000251645.2	-	3	557	c.505C>G	c.(505-507)Ctg>Gtg	p.L169V		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	169	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton	p.L169V(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				CACAGGGTCAGCTCATCCAGG	0.597000													6	54					0	0	1	0	0
EMC1	23065	broad.mit.edu	37	1	19545844	19545844	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:19545844T>A	ENST00000477853.1	-	23	2977	c.2935A>T	c.(2935-2937)Act>Tct	p.T979S	EMC1_ENST00000375199.3_Missense_Mutation_p.T978S|RP1-43E13.2_ENST00000437898.1_RNA|EMC1_ENST00000375208.3_Missense_Mutation_p.T957S|EMC1_ENST00000480380.1_5'UTR	NM_001271428.1|NM_015047.1	NP_001258357.1|NP_055862.1			ER membrane protein complex subunit 1									p.T979S(1)									AGTCTCTTAGTGATCATGGTG	0.498000													9	41					0	0	1	0	0
BRCA1	672	broad.mit.edu	37	17	41245544	41245544	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:41245544G>A	ENST00000309486.4	-	9	2143	c.1116C>T	c.(1114-1116)ctC>ctT	p.L372L	BRCA1_ENST00000357654.3_Silent_p.L668L|BRCA1_ENST00000354071.3_Silent_p.L668L|BRCA1_ENST00000351666.3_Intron|BRCA1_ENST00000591849.1_Intron|BRCA1_ENST00000591534.1_Intron|BRCA1_ENST00000493795.1_Silent_p.L621L|BRCA1_ENST00000586385.1_Intron|BRCA1_ENST00000468300.1_Intron|BRCA1_ENST00000471181.2_Silent_p.L668L|BRCA1_ENST00000352993.3_Intron|BRCA1_ENST00000491747.2_Intron|BRCA1_ENST00000346315.3_Silent_p.L668L	NM_007297.3	NP_009228.2	P38398	BRCA1_HUMAN	breast cancer 1, early onset	668					androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding	p.L668L(1)		NS(1)|breast(30)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(28)|ovary(36)|skin(2)|stomach(4)|urinary_tract(2)	120		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TACCTTCCATGAGTTGTAGGT	0.398000			"""D, Mis, N, F, S"""		ovarian	"""breast, ovarian"""		Homologous recombination	Hereditary Breast-Ovarian Cancer, BRCA1 type	TCGA Ovarian(2;0.000030)			13	93					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													4	20					2.56e-06	3.12889e-06	1	1	0
SPG11	80208	broad.mit.edu	37	15	44955626	44955626	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:44955626C>A	ENST00000261866.7	-	1	236	c.220G>T	c.(220-222)Ggc>Tgc	p.G74C	SPG11_ENST00000559193.1_Missense_Mutation_p.G74C|SPG11_ENST00000558319.1_Missense_Mutation_p.G74C|SPG11_ENST00000535302.2_Missense_Mutation_p.G74C|SPG11_ENST00000427534.2_Missense_Mutation_p.G74C	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	74					cell death	cytosol|integral to membrane|nucleus	protein binding	p.G74C(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CGACCCCCGCCCCGGCTGCCA	0.701000													3	10					0.00909568	0.00949403	1	1	0
OLFM4	10562	broad.mit.edu	37	13	53624329	53624329	+	Missense_Mutation	SNP	G	G	A	rs144683972		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr13:53624329G>A	ENST00000219022.2	+	5	1034	c.956G>A	c.(955-957)cGa>cAa	p.R319Q		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	319	Olfactomedin-like.				cell adhesion	extracellular space		p.R319Q(1)		breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		ATAAATGCTCGAGAGTTGCGG	0.433000													4	88					0	0	1	0	0
ZNF223	7766	broad.mit.edu	37	19	44570427	44570427	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:44570427A>G	ENST00000591793.1	+	7	859	c.776A>G	c.(775-777)aAt>aGt	p.N259S	ZNF223_ENST00000434772.3_Missense_Mutation_p.N149S			Q9UK11	ZN223_HUMAN	zinc finger protein 223	149					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.N149S(1)		endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				AAACCTTCCAATTGTGGGAAG	0.448000													4	150					0	0	1	0	0
OR4A16	81327	broad.mit.edu	37	11	55110891	55110891	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:55110891C>A	ENST00000314721.2	+	1	265	c.215C>A	c.(214-216)tCc>tAc	p.S72Y		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	72					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S72Y(1)		NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						GCCATATATTCCACTGCCATG	0.443000													43	155					6.61955e-31	9.19025e-31	1	1	0
LRRC4B	94030	broad.mit.edu	37	19	51022162	51022162	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:51022162G>A	ENST00000599957.1	-	3	1005	c.808C>T	c.(808-810)Cgc>Tgc	p.R270C	LRRC4B_ENST00000389201.3_Missense_Mutation_p.R270C			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	270						cell junction|integral to membrane|presynaptic membrane		p.R270C(1)		breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AAGGCGTTGCGCTCGATGGTG	0.657000													15	56					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58831476	58831476	+	Missense_Mutation	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr14:58831476T>C	ENST00000355431.3	+	20	3042	c.2669T>C	c.(2668-2670)aTt>aCt	p.I890T	ARID4A_ENST00000431317.2_Missense_Mutation_p.I890T|ARID4A_ENST00000395168.3_Missense_Mutation_p.I890T|ARID4A_ENST00000348476.3_Missense_Mutation_p.I890T	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	890					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.I890T(2)		NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AGTGATTGTATTGGATCTGAG	0.353000													3	38					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143141101	143141101	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:143141101C>A	ENST00000332690.1	+	1	556	c.556C>A	c.(556-558)Cgg>Agg	p.R186R	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	186					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity	p.R186R(1)		breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					CGATAGCATACGGAGCTACTG	0.398000													23	145					3.08376e-08	4.04567e-08	1	1	0
KDELR2	11014	broad.mit.edu	37	7	6505922	6505922	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:6505922G>A	ENST00000258739.4	-	4	568	c.384C>T	c.(382-384)tcC>tcT	p.S128S	DAGLB_ENST00000436575.1_Intron|KDELR2_ENST00000463747.1_Intron|KDELR2_ENST00000490996.1_Intron	NM_006854.3	NP_006845.1	P33947	ERD22_HUMAN	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	128					intracellular protein transport|protein retention in ER lumen|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	KDEL sequence binding|protein binding|receptor activity	p.S128S(1)		central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		GGATAGCCACGGACTCCAGGT	0.542000													9	58					0	0	1	0	0
OR52N1	79473	broad.mit.edu	37	11	5809322	5809322	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:5809322G>T	ENST00000317078.1	-	1	724	c.725C>A	c.(724-726)aCc>aAc	p.T242N	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T242N(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GGCAGTGCAGGTGCTGAAGGC	0.473000													8	60					0.000157383	0.000177211	1	1	0
CHDC2	286464	broad.mit.edu	37	X	36103615	36103615	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chrX:36103615C>A	ENST00000378660.1	+	5	789	c.601C>A	c.(601-603)Caa>Aaa	p.Q201K	CHDC2_ENST00000313548.4_Missense_Mutation_p.Q201K					calponin homology domain containing 2									p.Q201K(1)									AAGGGTAATTCAACTCCATTT	0.378000													12	30					2.10051e-16	2.86069e-16	1	1	0
CPED1	79974	broad.mit.edu	37	7	120704319	120704319	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:120704319C>G	ENST00000310396.5	+	5	1035	c.568C>G	c.(568-570)Cca>Gca	p.P190A	CPED1_ENST00000423795.1_5'UTR|CPED1_ENST00000450913.2_Missense_Mutation_p.P190A	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1									p.P190A(1)									AATACAGCAGCCACTTTGCAG	0.393000													6	61					0	0	1	0	0
ZNF155	7711	broad.mit.edu	37	19	44495760	44495760	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:44495760G>A	ENST00000270014.2	+	3	204	c.76G>A	c.(76-78)Gac>Aac	p.D26N	ZNF155_ENST00000590615.1_Missense_Mutation_p.D26N|ZNF155_ENST00000407951.2_Missense_Mutation_p.D37N	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	26	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.D26N(1)		endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				GGGGCTGCTGGACCCTGCCCA	0.517000													56	182					0	0	1	0	0
SPATA8	145946	broad.mit.edu	37	15	97327418	97327418	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:97327418G>T	ENST00000328504.3	+	2	392	c.125G>T	c.(124-126)tGt>tTt	p.C42F	SPATA8_ENST00000558553.1_Start_Codon_SNP_p.M1I	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	42								p.C42F(1)		large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			GCCATGACATGTCCCTGCGGC	0.592000													12	67					9.31168e-06	1.11897e-05	1	1	0
GRIA2	2891	broad.mit.edu	37	4	158238861	158238861	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:158238861C>G	ENST00000296526.7	+	5	1043	c.718C>G	c.(718-720)Ctg>Gtg	p.L240V	GRIA2_ENST00000393815.2_Missense_Mutation_p.L193V|GRIA2_ENST00000264426.9_Missense_Mutation_p.L240V|GRIA2_ENST00000449365.1_Missense_Mutation_p.L193V|GRIA2_ENST00000507898.1_Missense_Mutation_p.L193V	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	240					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity	p.L240V(2)		NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	CATTGCAAATCTGGTAGGTGA	0.249000													4	32					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89811675	89811675	+	Silent	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:89811675G>C	ENST00000310775.7	+	10	887	c.801G>C	c.(799-801)gtG>gtC	p.V267V	FANCI_ENST00000300027.8_Silent_p.V267V	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	267					cell cycle|DNA repair	nucleoplasm	protein binding	p.E268*(2)		breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTCGTCATGTGGAAGGCACCA	0.413000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	150					0	0	1	0	0
OR1S2	219958	broad.mit.edu	37	11	57971611	57971611	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:57971611G>T	ENST00000302592.6	-	1	42	c.43C>A	c.(43-45)Cat>Aat	p.H15N		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H15N(1)		endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				TTTTCTTGATGCATATTTCTG	0.413000													17	95					1.02788e-11	1.37371e-11	1	1	0
VENTX	27287	broad.mit.edu	37	10	135053498	135053498	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:135053498G>A	ENST00000325980.9	+	3	976	c.465G>A	c.(463-465)ctG>ctA	p.L155L		NM_014468.2	NP_055283.1	O95231	VENTX_HUMAN	VENT homeobox	155					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.L155L(1)		NS(1)|endometrium(1)|large_intestine(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(1)	14		all_cancers(35;4.15e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;7.8e-06)|Epithelial(32;9.31e-06)|all cancers(32;1.19e-05)		ACCCCCAGCTGCACAGCCCCT	0.562000													13	77					0	0	1	0	0
USP28	57646	broad.mit.edu	37	11	113702712	113702712	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:113702712C>T	ENST00000003302.4	-	8	831	c.763G>A	c.(763-765)Gat>Aat	p.D255N	USP28_ENST00000542033.1_Intron|USP28_ENST00000545540.1_Missense_Mutation_p.D130N|USP28_ENST00000260188.5_Missense_Mutation_p.D255N|USP28_ENST00000537706.1_Missense_Mutation_p.D255N	NM_020886.2	NP_065937.1	Q96RU2	UBP28_HUMAN	ubiquitin specific peptidase 28	255					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.D255N(1)		breast(4)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(24)|ovary(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	59		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TCACTCACATCTTGCTATAAG	0.363000													4	23					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39636983	39636983	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:39636983C>A	ENST00000246639.2	-	1	409	c.277G>T	c.(277-279)Gcc>Tcc	p.A93S	KRT35_ENST00000393989.1_Missense_Mutation_p.A123S			Q92764	KRT35_HUMAN	keratin 35	123	Head.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity	p.A123S(1)|p.A123T(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				TCCAGGCTGGCGTTCTCCTGC	0.612000													7	97					0.000157383	0.000177211	1	1	0
OR52R1	119695	broad.mit.edu	37	11	4824855	4824855	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:4824855C>A	ENST00000380382.1	-	1	992	c.993G>T	c.(991-993)ttG>ttT	p.L331F	OR52R1_ENST00000356069.2_Missense_Mutation_p.L252F|MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L331F(1)|p.L251F(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TATAAAGAGCCAAGATGACAC	0.473000													14	74					3.27435e-08	4.25666e-08	1	1	0
COBLL1	22837	broad.mit.edu	37	2	165561011	165561011	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:165561011C>A	ENST00000375458.2	-	8	1389	c.1168G>T	c.(1168-1170)Gga>Tga	p.G390*	COBLL1_ENST00000392717.2_Nonsense_Mutation_p.G428*|COBLL1_ENST00000194871.6_Nonsense_Mutation_p.G456*|COBLL1_ENST00000342193.4_Nonsense_Mutation_p.G390*|COBLL1_ENST00000491126.2_5'UTR|COBLL1_ENST00000409184.3_Nonsense_Mutation_p.G428*	NM_001278460.1|NM_001278461.1	NP_001265389.1|NP_001265390.1	Q53SF7	COBL1_HUMAN	cordon-bleu WH2 repeat protein-like 1	428								p.G390*(1)		central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(12)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	47						GGAGGAACTCCATCTACTGGC	0.378000													12	101					0.411799	0.414699	1	1	0
MAPK8IP3	23162	broad.mit.edu	37	16	1798647	1798647	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:1798647A>G	ENST00000250894.4	+	8	1296	c.1139A>G	c.(1138-1140)gAc>gGc	p.D380G	MAPK8IP3_ENST00000356010.5_Missense_Mutation_p.D380G|MAPK8IP3_ENST00000568271.1_3'UTR	NM_015133.3	NP_055948.2	Q9UPT6	JIP3_HUMAN	mitogen-activated protein kinase 8 interacting protein 3	380					vesicle-mediated transport	Golgi membrane	kinesin binding|MAP-kinase scaffold activity|protein kinase binding	p.D381G(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(3)	42						ATCAACACCGACTCCCTGTAC	0.627000													5	36					0	0	1	0	0
BMS1	9790	broad.mit.edu	37	10	43315759	43315759	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:43315759G>A	ENST00000374518.4	+	16	2719	c.2656G>A	c.(2656-2658)Gtc>Atc	p.V886I		NM_014753.3	NP_055568.3	Q14692	BMS1_HUMAN	BMS1 ribosome biogenesis factor	886					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity	p.V886I(1)		NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(23)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGGATGTACGTCCGCATTGA	0.448000													15	70					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846983	47846983	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:47846983T>G	ENST00000339488.4	-	3	1630	c.1597A>C	c.(1597-1599)Agc>Cgc	p.S533R		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	533						integral to membrane	hedgehog receptor activity	p.S533C(1)|p.S533R(1)									TCCTGGACGCTGCTGTTCCAG	0.488000													3	26					0	0	1	0	0
GPR22	2845	broad.mit.edu	37	7	107115089	107115089	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:107115089T>A	ENST00000304402.4	+	3	1927	c.584T>A	c.(583-585)cTt>cAt	p.L195H	COG5_ENST00000297135.3_Intron|COG5_ENST00000347053.3_Intron|COG5_ENST00000475638.2_Intron|COG5_ENST00000393603.2_Intron	NM_005295.2	NP_005286.2	Q99680	GPR22_HUMAN	G protein-coupled receptor 22	195						integral to plasma membrane	G-protein coupled receptor activity	p.L195H(1)		large_intestine(3)|lung(6)|ovary(2)|stomach(1)	12						AACAAGACACTTTTATGTGTC	0.313000													3	52					0	0	1	0	0
CD93	22918	broad.mit.edu	37	20	23065344	23065344	+	Missense_Mutation	SNP	G	G	T	rs148539804		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr20:23065344G>T	ENST00000246006.4	-	1	1633	c.1486C>A	c.(1486-1488)Cgt>Agt	p.R496S		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	496				R -> Q (in Ref. 1; AA sequence).	cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding	p.R496S(1)		NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GTTGCAGCACGGGGCACGGTG	0.622000													10	51					1.08611e-07	1.3624e-07	1	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3686514	3686514	+	Missense_Mutation	SNP	C	C	T	rs111336308	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr20:3686514C>T	ENST00000344754.4	-	3	582	c.583G>A	c.(583-585)Ggc>Agc	p.G195S	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.G195S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	195	Ig-like C2-type 1.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding	p.G195S(1)		NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						TGGCCGACGCCGGTGGGCTCA	0.642000													14	105					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11100015	11100015	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:11100015C>T	ENST00000358026.2	+	7	1425	c.1141C>T	c.(1141-1143)Cga>Tga	p.R381*	SMARCA4_ENST00000450717.3_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000413806.3_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000444061.3_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000344626.4_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000590574.1_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000589677.1_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000541122.2_Nonsense_Mutation_p.R381*|SMARCA4_ENST00000429416.3_Nonsense_Mutation_p.R381*	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	381					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.R381*(2)|p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CATCGCACACCGAATTCAGGA	0.607000			"""F, N, Mis"""		NSCLC								19	85					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7618423	7618423	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:7618423C>T	ENST00000256861.6	-	10	2049	c.1971G>A	c.(1969-1971)acG>acA	p.T657T	ITIH5_ENST00000397146.2_Silent_p.T657T|ITIH5_ENST00000397145.2_Silent_p.T657T|ITIH5_ENST00000298441.6_Silent_p.T443T|ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000446830.2_Silent_p.T439T	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	657					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.T657T(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TACCTGGCTGCGTGCCAGCTC	0.682000													4	18					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7809897	7809897	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:7809897A>G	ENST00000380358.4	+	29	4563	c.4562A>G	c.(4561-4563)cAt>cGt	p.H1521R	CHD3_ENST00000330494.7_Missense_Mutation_p.H1462R|CHD3_ENST00000358181.4_Missense_Mutation_p.H1462R	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1462					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding	p.H1462R(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TTCATGCGCCATCTGTGTGAG	0.612000													12	82					0	0	1	0	0
FITM1	161247	broad.mit.edu	37	14	24600930	24600930	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr14:24600930G>C	ENST00000267426.5	+	1	447	c.158G>C	c.(157-159)cGg>cCg	p.R53P	RP11-468E2.6_ENST00000558325.1_Missense_Mutation_p.240_240insT	NM_203402.2	NP_981947.1	A5D6W6	FITM1_HUMAN	fat storage-inducing transmembrane protein 1	53					lipid particle organization|positive regulation of sequestering of triglyceride	endoplasmic reticulum membrane|integral to membrane		p.R53P(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	11						CCCTGCTTACGGCGCCTCTAC	0.627000													4	42					0	0	1	0	0
CAPN5	726	broad.mit.edu	37	11	76829343	76829343	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:76829343A>G	ENST00000278559.3	+	8	1301	c.1112A>G	c.(1111-1113)cAg>cGg	p.Q371R	CAPN5_ENST00000529629.1_Missense_Mutation_p.Q371R|CAPN5_ENST00000456580.2_Missense_Mutation_p.Q411R|CAPN5_ENST00000531028.1_Intron	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	371	Domain III.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity	p.Q371R(1)		NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						GACCCGCGACAGAACCGCGGT	0.637000													3	18					0	0	1	0	0
C5AR1	728	broad.mit.edu	37	19	47823129	47823129	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:47823129C>T	ENST00000355085.3	+	2	117	c.95C>T	c.(94-96)aCg>aTg	p.T32M		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	32					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity	p.T32M(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		ACTTCTAACACGCTGCGTGTT	0.532000													11	48					0	0	1	0	0
MS4A4A	51338	broad.mit.edu	37	11	60070111	60070111	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:60070111C>T	ENST00000355131.3	+	6	633	c.410C>T	c.(409-411)gCg>gTg	p.A137V	MS4A4A_ENST00000532114.1_Intron|MS4A4A_ENST00000395016.3_Missense_Mutation_p.A137V|MS4A4A_ENST00000337908.4_Missense_Mutation_p.A156V	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	156						integral to membrane	receptor activity	p.A156V(1)|p.A137V(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						TTTAGCTTGGCGTTTTATTCA	0.403000													8	105					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17058020	17058020	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:17058020C>T	ENST00000443236.1	-	21	2698	c.2667G>A	c.(2665-2667)tcG>tcA	p.S889S		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	842						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity	p.S889S(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CCTTGGGAACCGAGAGCTTCA	0.607000													12	132					0	0	1	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52148735	52148735	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:52148735C>A	ENST00000360844.6	-	4	790	c.749G>T	c.(748-750)gGc>gTc	p.G250V	SIGLEC5_ENST00000534261.2_5'UTR|SIGLEC5_ENST00000222107.4_Intron|SIGLEC5_ENST00000599649.1_Intron|SIGLEC5_ENST00000429354.3_Intron	NM_001098612.1	NP_001092082.1	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14	250	Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding	p.G250V(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		CCTACCTGTGCCTGTGCCATT	0.552000													8	27					0.00448238	0.00478344	1	1	0
ORC1	4998	broad.mit.edu	37	1	52867116	52867116	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:52867116G>A	ENST00000371568.3	-	3	359	c.141C>T	c.(139-141)atC>atT	p.I47I	ORC1_ENST00000371566.1_Silent_p.I47I	NM_001190818.1|NM_001190819.1|NM_004153.3	NP_001177747.1|NP_001177748.1|NP_004144.2	Q13415	ORC1_HUMAN	origin recognition complex, subunit 1	47	BAH.				cell cycle checkpoint|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nuclear origin of replication recognition complex|nucleolus|nucleoplasm|plasma membrane	ATP binding|DNA binding|nucleoside-triphosphatase activity|protein binding	p.I47I(1)		breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						GTCCAATCTGGATGTGAATCT	0.408000													16	92					0	0	1	0	0
FAM183B	340286	broad.mit.edu	37	7	38725520	38725520	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:38725520C>T	ENST00000409072.3	-	2	1020	c.86G>A	c.(85-87)cGa>cAa	p.R29Q						family with sequence similarity 183, member B									p.R29Q(4)		endometrium(1)|lung(7)	8						TTTCTGGGTTCGTAACTCTTT	0.542000													7	60					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87080995	87080995	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:87080995G>A	ENST00000265723.4	-	7	763	c.652C>T	c.(652-654)Ctt>Ttt	p.L218F	ABCB4_ENST00000359206.3_Missense_Mutation_p.L218F|ABCB4_ENST00000358400.3_Missense_Mutation_p.L218F|ABCB4_ENST00000453593.1_Missense_Mutation_p.L218F|ABCB4_ENST00000545634.1_Missense_Mutation_p.L218F	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	218	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity	p.L218F(1)		breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					ATTATCACAAGGGTGAGCTTC	0.468000													7	68					0	0	1	0	0
RNF144B	255488	broad.mit.edu	37	6	18457500	18457500	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:18457500A>G	ENST00000259939.3	+	5	763	c.446A>G	c.(445-447)cAc>cGc	p.H149R	RNF144B_ENST00000429054.2_Missense_Mutation_p.H60R	NM_182757.3	NP_877434.2	Q7Z419	R144B_HUMAN	ring finger protein 144B	149					apoptosis|positive regulation of anti-apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.H149R(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(7)	11	Ovarian(93;0.00365)|Breast(50;0.0145)	all_hematologic(90;0.0536)	OV - Ovarian serous cystadenocarcinoma(7;0.00165)|all cancers(50;0.0102)|Epithelial(50;0.0105)			CCTTCTTGCCACCTGAAATTC	0.552000													25	290					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23794038	23794038	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:23794038T>G	ENST00000354639.3	+	10	1633	c.1169T>G	c.(1168-1170)aTa>aGa	p.I390R	STK31_ENST00000433467.2_Missense_Mutation_p.I413R|STK31_ENST00000428484.1_Missense_Mutation_p.I390R|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000355870.3_Missense_Mutation_p.I413R	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	413							ATP binding|nucleic acid binding|protein serine/threonine kinase activity	p.I413R(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						GGATTAGAGATAATATGGGCA	0.388000													5	155					0	0	1	0	0
SLC25A10	1468	broad.mit.edu	37	17	79682037	79682037	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:79682037C>T	ENST00000331531.5	+	2	268	c.148C>T	c.(148-150)Cgg>Tgg	p.R50W	SLC25A10_ENST00000571730.1_Missense_Mutation_p.R205W|SLC25A10_ENST00000350690.5_Missense_Mutation_p.R50W|SLC25A10_ENST00000545862.1_Missense_Mutation_p.R7W|SLC25A10_ENST00000541223.1_Missense_Mutation_p.R205W	NM_001270888.1	NP_001257817.1	Q9UBX3	DIC_HUMAN	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	50					gluconeogenesis|mitochondrial transport	integral to membrane|mitochondrial inner membrane|nucleus	protein binding	p.R50W(1)		endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(2)	14	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0117)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)		Succinic acid(DB00139)	CATGGCGCTGCGGGTGGTGCG	0.667000													8	32					0	0	1	0	0
TTK	7272	broad.mit.edu	37	6	80746194	80746194	+	Missense_Mutation	SNP	A	A	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:80746194A>C	ENST00000509894.1	+	17	2753	c.1924A>C	c.(1924-1926)Att>Ctt	p.I642L	TTK_ENST00000230510.3_Missense_Mutation_p.I642L|TTK_ENST00000369798.2_Missense_Mutation_p.I643L			P33981	TTK_HUMAN	TTK protein kinase	643	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.I643L(1)|p.I627L(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TTTTAAAGGCATTGTTCACAG	0.328000													12	79					0	0	1	0	0
HAVCR2	84868	broad.mit.edu	37	5	156535979	156535979	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:156535979G>A	ENST00000307851.4	-	1	746	c.16C>T	c.(16-18)Ccc>Tcc	p.P6S	HAVCR2_ENST00000522593.1_Missense_Mutation_p.P6S|CTB-120L21.1_ENST00000517708.1_RNA	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	6						integral to membrane		p.P6S(1)		cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAGTCAAAGGGAAGATGTGAA	0.448000													9	51					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40408275	40408275	+	Missense_Mutation	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:40408275A>T	ENST00000221347.6	-	8	4571	c.4564T>A	c.(4564-4566)Tgg>Agg	p.W1522R		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1522						extracellular region	protein binding	p.W1522R(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCAGTCCTCCAGGGCTCCACG	0.622000													44	54					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128792	45128792	+	RNA	SNP	G	G	T	rs143713325	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:45128792G>T	ENST00000575173.1	-	0	418																											AATTCAGGTTGTCAGAATGCA	0.373000													3	61					0.115264	0.117734	1	1	0
WDR38	401551	broad.mit.edu	37	9	127619095	127619095	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:127619095T>A	ENST00000373574.1	+	7	759	c.703T>A	c.(703-705)Tgg>Agg	p.W235R		NM_001045476.1|NM_001276374.1	NP_001038941.1|NP_001263303.1	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	235								p.W235R(1)		breast(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						CCATGTCACCTGGGTGAAGAG	0.617000													14	52					0	0	1	0	0
SLC39A6	25800	broad.mit.edu	37	18	33694106	33694106	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr18:33694106C>A	ENST00000269187.5	-	7	2010	c.1797G>T	c.(1795-1797)gtG>gtT	p.V599V	SLC39A6_ENST00000440549.2_Silent_p.V324V|SLC39A6_ENST00000590986.1_Silent_p.V599V	NM_012319.3	NP_036451.3	Q13433	S39A6_HUMAN	solute carrier family 39 (zinc transporter), member 6	599						integral to membrane|lamellipodium membrane	zinc ion transmembrane transporter activity	p.V599V(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(4)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	41						CACCCATTATCACCATCCAGG	0.478000													5	60					3.59834e-05	4.18343e-05	1	1	0
C2orf70	339778	broad.mit.edu	37	2	26802211	26802211	+	Missense_Mutation	SNP	G	G	A	rs147381361	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:26802211G>A	ENST00000409392.1	+	5	575	c.473G>A	c.(472-474)cGa>cAa	p.R158Q	C2orf70_ENST00000329615.3_Missense_Mutation_p.E171K			A6NJV1	CB070_HUMAN	chromosome 2 open reading frame 70	0								p.E171K(1)|p.E171*(1)		breast(3)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	13						ACTAGCCCCCGAGAACCTGAA	0.532000													13	46					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8751902	8751902	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:8751902C>T	ENST00000534127.1	-	6	1320	c.935G>A	c.(934-936)cGg>cAg	p.R312Q	ST5_ENST00000530438.1_Intron|ST5_ENST00000313726.6_Missense_Mutation_p.R312Q|ST5_ENST00000526757.1_Intron|ST5_ENST00000357665.1_Missense_Mutation_p.R312Q	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	312					positive regulation of ERK1 and ERK2 cascade		protein binding	p.R312Q(1)		NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CCTTTTCCCCCGGTCCACGCT	0.667000													17	71					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74838084	74838084	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:74838084T>A	ENST00000358399.3	+	7	748	c.655T>A	c.(655-657)Tct>Act	p.S219T	GDA_ENST00000376986.1_Intron|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000376989.3_Intron|GDA_ENST00000238018.4_Missense_Mutation_p.S219T|GDA_ENST00000545168.1_Missense_Mutation_p.S145T	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	219					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding	p.S219T(2)		central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		CCTCTCCTGCTCTGAGACTTT	0.413000													12	71					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33891898	33891898	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:33891898C>A	ENST00000504830.1	-	1	399	c.64G>T	c.(64-66)Ggg>Tgg	p.G22W	ADAMTS12_ENST00000515401.1_Missense_Mutation_p.G22W|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.G22W	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	22					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G22W(2)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CAAAGCGCCCCAAAGTTAAGG	0.498000										HNSCC(64;0.19)			14	106					0.000308642	0.000339506	1	1	0
SYBU	55638	broad.mit.edu	37	8	110631185	110631185	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr8:110631185G>A	ENST00000399066.3	-	2	1031	c.304C>T	c.(304-306)Cct>Tct	p.P102S	SYBU_ENST00000440310.1_Missense_Mutation_p.P105S|SYBU_ENST00000408889.3_5'UTR|SYBU_ENST00000528647.1_Missense_Mutation_p.P104S|SYBU_ENST00000528331.1_5'UTR|SYBU_ENST00000419099.1_Missense_Mutation_p.P104S|SYBU_ENST00000422135.1_Missense_Mutation_p.P105S|SYBU_ENST00000408908.2_Missense_Mutation_p.P105S|SYBU_ENST00000276646.9_Missense_Mutation_p.P105S|SYBU_ENST00000533065.1_5'UTR|SYBU_ENST00000532779.1_Missense_Mutation_p.P37S|SYBU_ENST00000533171.1_Missense_Mutation_p.P105S|SYBU_ENST00000433638.1_Missense_Mutation_p.P105S|SYBU_ENST00000533895.1_Missense_Mutation_p.P104S|SYBU_ENST00000446070.2_Missense_Mutation_p.P104S|SYBU_ENST00000424158.2_Missense_Mutation_p.P110S	NM_001099756.1	NP_001093226.1	Q9NX95	SYBU_HUMAN	syntabulin (syntaxin-interacting)	105	Ser-rich.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane		p.P102S(1)		NS(1)|breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	30						TCACTTCCAGGGCAAAAGCCA	0.483000													5	139					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685846	100685846	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:100685846C>T	ENST00000306151.4	+	3	11213	c.11149C>T	c.(11149-11151)Cct>Tct	p.P3717S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3717	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.P3717S(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTTTCAACACCTTCTGTTGT	0.507000													11	170					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834457	125834457	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:125834457C>A	ENST00000299308.3	+	2	520	c.512C>A	c.(511-513)gCa>gAa	p.A171E	TMEM132B_ENST00000418253.2_3'UTR	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	171						integral to membrane		p.A171E(1)		NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGGGAAGTGGCAGCCAGCTGT	0.592000													5	82					8.12818e-05	9.37363e-05	1	1	0
COX11	1353	broad.mit.edu	37	17	53045706	53045706	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:53045706G>T	ENST00000299335.3	-	1	440	c.302C>A	c.(301-303)gCt>gAt	p.A101D	COX11_ENST00000571584.1_Missense_Mutation_p.A101D	NM_004375.3	NP_004366.1	Q9Y6N1	COX11_HUMAN	cytochrome c oxidase assembly homolog 11 (yeast)	101					respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	copper ion binding|cytochrome-c oxidase activity|electron carrier activity	p.A101D(1)		endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|prostate(1)	9						CACGGCGACAGCGGCCACGTA	0.697000													3	63					1	1	1	1	0
NR1H4	9971	broad.mit.edu	37	12	100928726	100928726	+	Silent	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:100928726T>C	ENST00000548884.1	+	6	1186	c.645T>C	c.(643-645)caT>caC	p.H215H	NR1H4_ENST00000392986.3_Silent_p.H219H|NR1H4_ENST00000551379.1_Silent_p.H229H|NR1H4_ENST00000549996.1_Silent_p.H168H|NR1H4_ENST00000188403.7_Silent_p.H225H	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	229					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.H215H(1)|p.H229H(1)		NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						TGAAGCAGCATGCAGATCAGA	0.413000													13	60					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19653418	19653418	+	Missense_Mutation	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr21:19653418A>T	ENST00000284885.3	-	22	2640	c.2607T>A	c.(2605-2607)aaT>aaA	p.N869K		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	869	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity	p.N869K(1)		NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TTCTTCGCCTATTGTAATGAG	0.378000													14	163					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163291819	163291819	+	Missense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:163291819C>A	ENST00000332142.5	-	8	1942	c.1843G>T	c.(1843-1845)Gtc>Ttc	p.V615F	KCNH7_ENST00000328032.4_Missense_Mutation_p.V608F	NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	615					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity	p.V615F(1)|p.V608F(1)		NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AGTGCTGTGACGTATTTGTCT	0.398000													10	80					2.17888e-05	2.5965e-05	1	1	0
C17orf103	256302	broad.mit.edu	37	17	21146727	21146727	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr17:21146727C>T	ENST00000399011.2	-	4	239	c.238G>A	c.(238-240)Gtg>Atg	p.V80M	C17orf103_ENST00000468196.1_Silent_p.S80S	NM_152914.2	NP_690878.2	Q8N6N6	GTL3B_HUMAN	chromosome 17 open reading frame 103	81								p.V80M(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6						TCCTCCACCACGAAGTCCAGG	0.657000													4	38					0	0	1	0	0
CDCP1	64866	broad.mit.edu	37	3	45134848	45134848	+	Silent	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr3:45134848G>T	ENST00000296129.1	-	6	1682	c.1548C>A	c.(1546-1548)acC>acA	p.T516T		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	516	CUB.					extracellular region|integral to membrane|plasma membrane		p.T516T(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		AGGTGCGAAGGGTCACCGAGA	0.572000													5	84					3.59834e-05	4.18343e-05	1	1	0
CHCHD2	51142	broad.mit.edu	37	7	56172005	56172005	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:56172005C>T	ENST00000395422.3	-	2	376	c.214G>A	c.(214-216)Gtg>Atg	p.V72M		NM_016139.2	NP_057223.1	Q9Y6H1	CHCH2_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 2	72						mitochondrion		p.V72M(1)		endometrium(1)|large_intestine(1)|lung(3)	5	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GTGTGCCCCACAGCAGAGCCC	0.612000													5	39					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133727632	133727632	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:133727632G>T	ENST00000248211.6	+	3	274	c.52G>T	c.(52-54)Gat>Tat	p.D18Y	ZNF10_ENST00000540927.1_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.D18Y|CTD-2140B24.4_ENST00000540096.2_Missense_Mutation_p.D18Y|ZNF268_ENST00000416488.1_Missense_Mutation_p.D18Y|ZNF10_ENST00000402932.2_Missense_Mutation_p.D18Y	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.D18Y(1)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		GACCTTCAAGGATGTATTTGT	0.458000													13	81					0.000219431	0.000245146	1	1	0
PRSS22	64063	broad.mit.edu	37	16	2906186	2906186	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:2906186C>A	ENST00000161006.3	-	3	243	c.178G>T	c.(178-180)Gag>Tag	p.E60*	PRSS22_ENST00000571228.1_Nonsense_Mutation_p.E60*|PRSS22_ENST00000574768.1_5'UTR	NM_022119.3	NP_071402.1	Q9GZN4	BSSP4_HUMAN	protease, serine, 22	60	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.E60*(1)		central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|skin(2)	10						CAGGGCCACTCGCTGTCAGTG	0.602000													10	47					0.00829132	0.00878266	1	1	0
TTYH1	57348	broad.mit.edu	37	19	54937858	54937858	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:54937858C>T	ENST00000301194.4	+	5	769	c.647C>T	c.(646-648)gCc>gTc	p.A216V	TTYH1_ENST00000376531.3_Missense_Mutation_p.A216V|TTYH1_ENST00000391739.3_Missense_Mutation_p.A265V|TTYH1_ENST00000376530.3_Missense_Mutation_p.A216V|TTYH1_ENST00000489425.1_3'UTR			Q9H313	TTYH1_HUMAN	tweety family member 1	216					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity	p.A216V(2)		endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		AGGTGGCTGGCCTACGTCCTC	0.647000													9	88					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139164048	139164048	+	Missense_Mutation	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr8:139164048G>T	ENST00000395297.1	-	13	2840	c.2670C>A	c.(2668-2670)aaC>aaA	p.N890K		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	890								p.N890K(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGGTCCTGGGGTTTTCAAGTG	0.468000										HNSCC(54;0.14)			4	151					0.150653	0.15279	1	1	0
TPSAB1	7177	broad.mit.edu	37	16	1291189	1291189	+	Missense_Mutation	SNP	G	G	A	rs143010092		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr16:1291189G>A	ENST00000461509.2	+	2	312	c.118G>A	c.(118-120)Ggg>Agg	p.G40R	TPSAB1_ENST00000338844.3_Missense_Mutation_p.G33R			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	33	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity	p.G33R(1)		NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				GGGCATCGTCGGGGGTCAGGA	0.701000													4	44					0	0	1	0	0
MON2	23041	broad.mit.edu	37	12	62938755	62938755	+	Silent	SNP	A	A	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:62938755A>T	ENST00000393630.3	+	22	2938	c.2547A>T	c.(2545-2547)acA>acT	p.T849T	MON2_ENST00000280379.6_Silent_p.T849T|MON2_ENST00000393629.2_Silent_p.T848T|MON2_ENST00000552738.1_Silent_p.T825T|MON2_ENST00000552115.1_Silent_p.T848T|MON2_ENST00000393632.2_Silent_p.T848T|MON2_ENST00000546600.1_Silent_p.T848T	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	849					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding	p.T848T(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CAGGATTAACATTTAACCATG	0.333000													12	51					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154128189	154128189	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chrX:154128189G>A	ENST00000360256.4	-	21	6425	c.6225C>T	c.(6223-6225)tcC>tcT	p.S2075S		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2075	F5/8 type C 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding	p.S2075S(2)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGATTGATCCGGAATAATGAA	0.418000													4	26					0	0	1	0	0
SHOX	6473	broad.mit.edu	37	X	591835	591835	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chrX:591835T>A	ENST00000381578.1	+	2	894	c.203T>A	c.(202-204)gTg>gAg	p.V68E	SHOX_ENST00000334060.3_Missense_Mutation_p.V68E|SHOX_ENST00000554971.1_Missense_Mutation_p.V68E|SHOX_ENST00000381575.1_Missense_Mutation_p.V68E	NM_000451.3	NP_000442.1	O15266	SHOX_HUMAN	short stature homeobox	68					skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.V68E(1)		endometrium(3)|lung(9)|prostate(1)	13		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CACTGCCCGGTGCATTTGTTC	0.602000													9	88					0	0	1	0	0
OR1N1	138883	broad.mit.edu	37	9	125289309	125289309	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:125289309G>A	ENST00000304880.2	-	1	263	c.264C>T	c.(262-264)caC>caT	p.H88H		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H88H(1)		breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						AGGAGATGGTGTGATGCCGAG	0.473000													5	45					0	0	1	0	0
SEC24D	9871	broad.mit.edu	37	4	119736190	119736190	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:119736190G>C	ENST00000379735.5	-	6	1068	c.797C>G	c.(796-798)cCt>cGt	p.P266R	SEC24D_ENST00000280551.6_Missense_Mutation_p.P265R|SEC24D_ENST00000419654.2_5'UTR	NM_014822.2	NP_055637.2	O94855	SC24D_HUMAN	SEC24 family member D	265	Pro-rich.				COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	zinc ion binding	p.P265R(1)		breast(3)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37						TACTGGGCTAGGGATAGAGTC	0.502000													8	87					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24808294	24808294	+	Missense_Mutation	SNP	T	T	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr14:24808294T>A	ENST00000216274.5	-	3	616	c.398A>T	c.(397-399)gAc>gTc	p.D133V		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	133	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity	p.D133V(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		CGGGTTCTGGTCGTGCAGGTA	0.637000													5	50					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													4	37					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25886922	25886922	+	Missense_Mutation	SNP	G	G	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr10:25886922G>C	ENST00000376351.3	+	11	2726	c.2367G>C	c.(2365-2367)agG>agC	p.R789S	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	789						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R789S(1)		breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCCTCATCAGGAAGAACCCCC	0.552000													13	67					0	0	1	0	0
KLHL8	57563	broad.mit.edu	37	4	88106793	88106793	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:88106793G>A	ENST00000273963.5	-	3	716	c.375C>T	c.(373-375)gtC>gtT	p.V125V	KLHL8_ENST00000512111.1_Silent_p.V125V|KLHL8_ENST00000425278.2_Intron|KLHL8_ENST00000498875.2_Intron|KLHL8_ENST00000545252.1_Intron	NM_020803.3	NP_065854.3	Q9P2G9	KLHL8_HUMAN	kelch-like family member 8	125	BTB.							p.V125V(1)		breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|stomach(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000603)		GTGAAGAATAGACAAACTTTA	0.418000													5	48					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44955627	44955627	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:44955627C>A	ENST00000261866.7	-	1	235	c.219G>T	c.(217-219)cgG>cgT	p.R73R	SPG11_ENST00000559193.1_Silent_p.R73R|SPG11_ENST00000558319.1_Silent_p.R73R|SPG11_ENST00000535302.2_Silent_p.R73R|SPG11_ENST00000427534.2_Silent_p.R73R	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	73					cell death	cytosol|integral to membrane|nucleus	protein binding	p.G74C(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		GACCCCCGCCCCGGCTGCCAG	0.697000													3	10					0.00909568	0.00949403	1	1	0
UBC	7316	broad.mit.edu	37	12	125397791	125397791	+	Missense_Mutation	SNP	T	T	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:125397791T>G	ENST00000536769.1	-	1	2103	c.527A>C	c.(526-528)gAg>gCg	p.E176A	UBC_ENST00000339647.5_Missense_Mutation_p.E176A|UBC_ENST00000546120.1_Intron|UBC_ENST00000538617.1_Intron			P0CG48	UBC_HUMAN	ubiquitin C	176	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding	p.E176A(1)		breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		CTTGACATTCTCGATGGTGTC	0.527000													10	142					0	0	1	0	0
AUP1	550	broad.mit.edu	37	2	74755588	74755588	+	Missense_Mutation	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr2:74755588C>T	ENST00000377526.3	-	5	862	c.553G>A	c.(553-555)Gta>Ata	p.V185I		NM_181575.3	NP_853553.1	Q9Y679	AUP1_HUMAN	ancient ubiquitous protein 1	251						endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding	p.V185I(1)		breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(7)	11						AGAGGTTGTACCACATCTTGG	0.502000													7	32					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496708	20496708	+	RNA	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr15:20496708A>G	ENST00000555186.1	+	0	761					NR_038836.1																						TGAACATGAAAGAAATGTACC	0.423000													3	25					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110822018	110822018	+	Silent	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr13:110822018A>G	ENST00000375820.4	-	43	3955	c.3834T>C	c.(3832-3834)ggT>ggC	p.G1278G		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1278	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding	p.G1278G(1)|p.G921G(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			GCCCTGGGACACCGGGTGCTC	0.512000													15	81					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248790184	248790184	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:248790184C>G	ENST00000330803.2	-	1	307	c.246G>C	c.(244-246)atG>atC	p.M82I		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M82I(1)		breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTTTAGAAACCATGTCTGCCA	0.502000													14	37					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94487168	94487168	+	Silent	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:94487168G>A	ENST00000375708.3	-	9	1806	c.1608C>T	c.(1606-1608)gtC>gtT	p.V536V	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Silent_p.V396V	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	536	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding	p.V536V(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GCAGGCAGACGACGTTGGGGT	0.627000													11	63					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110455939	110455939	+	Silent	SNP	G	G	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr8:110455939G>T	ENST00000378402.5	+	37	4703	c.4599G>T	c.(4597-4599)gtG>gtT	p.V1533V		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1533					immune response	cytosol|extracellular space|integral to membrane	receptor activity	p.V1535V(1)		NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAAGCTCTGTGGCAGGCTGCC	0.403000										HNSCC(38;0.096)			7	25					0.0477658	0.0491403	1	1	0
TCERG1	10915	broad.mit.edu	37	5	145883476	145883476	+	Silent	SNP	C	C	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr5:145883476C>A	ENST00000296702.5	+	18	2675	c.2637C>A	c.(2635-2637)gcC>gcA	p.A879A	TCERG1_ENST00000394421.2_Silent_p.A858A|TCERG1_ENST00000509787.1_3'UTR	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	879					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity	p.A879A(1)		breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTCAAAAGGCCCGTTCAGAAC	0.433000													6	64					0.0477658	0.0491403	1	1	0
BCRP7	100133163	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													4	6					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31025842	31025842	+	Missense_Mutation	SNP	C	C	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:31025842C>G	ENST00000355537.3	+	3	2406	c.2259C>G	c.(2257-2259)tgC>tgG	p.C753W		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	753					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.C753W(1)|p.C753*(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGAAGGACTGCCCGTACTGTG	0.602000													8	124					0	0	1	0	0
C3AR1	719	broad.mit.edu	37	12	8211605	8211605	+	Missense_Mutation	SNP	A	A	G			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr12:8211605A>G	ENST00000307637.4	-	2	1380	c.1177T>C	c.(1177-1179)Tac>Cac	p.Y393H		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	393					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity	p.Y393H(1)		breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		AAAATGTGGTATGGAGTCCAG	0.512000													5	34					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564566	176564566	+	Missense_Mutation	SNP	G	G	A			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr1:176564566G>A	ENST00000367662.3	+	3	2990	c.1826G>A	c.(1825-1827)gGg>gAg	p.G609E	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G609E	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	609	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.G609E(2)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GGCTATGATGGGGGTGACTGC	0.587000													6	66					0	0	1	0	0
HOMER3	9454	broad.mit.edu	37	19	19042357	19042357	+	Silent	SNP	C	C	T			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:19042357C>T	ENST00000539827.1	-	7	1420	c.768G>A	c.(766-768)tcG>tcA	p.S256S	HOMER3_ENST00000433218.2_Silent_p.S256S|HOMER3_ENST00000221222.11_Silent_p.S256S|HOMER3_ENST00000392351.3_Silent_p.S256S|AC002985.3_ENST00000596918.1_3'UTR|HOMER3_ENST00000594439.1_Silent_p.S220S|HOMER3_ENST00000355887.6_Silent_p.S256S|HOMER3_ENST00000594794.1_Silent_p.S47S|HOMER3_ENST00000542541.2_Silent_p.S256S			Q9NSC5	HOME3_HUMAN	homer homolog 3 (Drosophila)	256					metabotropic glutamate receptor signaling pathway|protein targeting	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	protein binding	p.S256S(1)		endometrium(3)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	10			Epithelial(12;0.0107)			GCTGTTCCAGCGACTGGCCCT	0.637000													5	100					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77816907	77816912	+	In_Frame_Del	DEL	ACATTT	ACATTT	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr4:77816907_77816912delACATTT	ENST00000334306.2	-	1	2090_2095	c.2091_2096delAAATGT	c.(2089-2097)gtc>gt	p.VNV697del		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	697																	GCTGTCCCTGACATTTACCCGAGAAG	0.539													27	334	---	---	---	---					
PXDC1	221749	broad.mit.edu	37	6	3751655	3751657	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:3751655_3751657delCTC	ENST00000380283.4	-	1	603_605	c.109_111delGAG	c.(109-111)del	p.E37del	RP11-420L9.5_ENST00000603791.1_RNA|PXDC1_ENST00000477592.2_5'UTR	NM_183373.3	NP_899229.2	Q5TGL8	CF145_HUMAN	PX domain containing 1	37	PX.				cell communication		phosphatidylinositol binding										TCTCGAAGAACTCCTCTTCGTCG	0.690													2	4	---	---	---	---					
TRERF1	55809	broad.mit.edu	37	6	42196333	42196333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr6:42196333delT	ENST00000541110.1	-	18	3981	c.3413delA	c.(3412-3414)agfs	p.K1138fs	TRERF1_ENST00000340840.2_Frame_Shift_Del_p.K1047fs|TRERF1_ENST00000354325.2_Frame_Shift_Del_p.K1035fs|TRERF1_ENST00000372922.4_Frame_Shift_Del_p.K1118fs|TRERF1_ENST00000372917.4_Frame_Shift_Del_p.K1047fs			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1118	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTTCTGAGCCTTTTGCCTCTG	0.542													8	649	---	---	---	---					
TRGV3	6976	broad.mit.edu	37	7	38398480	38398481	+	RNA	INS	-	-	AA	rs3056123		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr7:38398480_38398481insAA	ENST00000390346.2	-	0	226																											GCACCCCTTTCAAGAAGAAAAC	0.480													7	37	---	---	---	---					
CTSV	1515	broad.mit.edu	37	9	99798905	99798905	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr9:99798905delC	ENST00000259470.5	-	5	770	c.521delG	c.(520-522)gcfs	p.G174fs	CTSV_ENST00000538255.1_Frame_Shift_Del_p.G174fs	NM_001333.3	NP_001324.2			cathepsin V																		GCCCTGATTGCCTTGAGGACG	0.522													9	70	---	---	---	---					
GAL3ST3	89792	broad.mit.edu	37	11	65810949	65810949	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr11:65810949delG	ENST00000312006.4	-	3	606	c.325delC	c.(325-327)gcfs	p.R109fs	GAL3ST3_ENST00000527878.1_Frame_Shift_Del_p.R109fs	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	109					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GAGAAGTTGCGGGGGTAGCAG	0.692													10	34	---	---	---	---					
CTC-512J12.4	0	broad.mit.edu	37	19	44917439	44917446	+	RNA	DEL	TTCCTTCC	TTCCTTCC	-	rs74404943		TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr19:44917439_44917446delTTCCTTCC	ENST00000588655.1	-	0	488																											ccttccttctttccttccttccttcctt	0.423													3	3	---	---	---	---					
TPTE	7179	broad.mit.edu	37	21	10944697	10944697	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-5420-01A-01D-1625-08	TCGA-05-5420-11A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8371b6a4-ffea-4fe5-b997-76ece85064a7	933f6f30-7a1a-4148-953e-f637b1e6c241	g.chr21:10944697delA	ENST00000298232.7	-	10	850	c.483delT	c.(481-483)ttfs	p.F161fs	TPTE_ENST00000342420.5_Frame_Shift_Del_p.F141fs|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Frame_Shift_Del_p.F179fs	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	179					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACTTAATGTCAAAAAAAATGT	0.299													8	299	---	---	---	---