Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DCUN1D4	23142	broad.mit.edu	37	4	52740525	52740525	+	Silent	SNP	A	A	G	rs146614901		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:52740525A>G	ENST00000334635.5	+	4	405	c.225A>G	c.(223-225)ttA>ttG	p.L75L	DCUN1D4_ENST00000451288.2_Silent_p.L119L|DCUN1D4_ENST00000513800.1_3'UTR|DCUN1D4_ENST00000381437.4_Silent_p.L15L|DCUN1D4_ENST00000381441.3_Silent_p.L75L	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	75										endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			GAGATGATTTATCTGCCAAGA	0.393000													6	73					0	0	0.047766	0	0
SEC23IP	11196	broad.mit.edu	37	10	121658365	121658365	+	Missense_Mutation	SNP	C	C	T	rs145784334	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:121658365C>T	ENST00000369075.3	+	2	662	c.590C>T	c.(589-591)gCa>gTa	p.A197V	SEC23IP_ENST00000543134.1_Intron	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	197	Interaction with SEC23A.|Pro-rich.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		CCTTACATTGCACCACCCCAG	0.547000													36	105					0	0	0.064281	0	0
PRAME	23532	broad.mit.edu	37	22	22890729	22890729	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:22890729G>T	ENST00000543184.1	-	5	2152	c.1290C>A	c.(1288-1290)ctC>ctA	p.L430L	PRAME_ENST00000539862.1_Silent_p.L414L|PRAME_ENST00000398741.1_Silent_p.L430L|PRAME_ENST00000398743.2_Silent_p.L430L|PRAME_ENST00000405655.3_Silent_p.L430L|PRAME_ENST00000424204.2_Silent_p.L414L|PRAME_ENST00000402697.1_Silent_p.L430L	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	430	Mediates interaction with RARA.				apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		TCAGCCCGATGAGGTGCTGCA	0.562000													14	41					7.93312e-07	1.01654e-06	0.119110	1	0
ROBO2	6092	broad.mit.edu	37	3	77147176	77147176	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:77147176C>A	ENST00000461745.1	+	2	973	c.73C>A	c.(73-75)Cgc>Agc	p.R25S	ROBO2_ENST00000332191.8_Missense_Mutation_p.R25S|ROBO2_ENST00000487694.3_Missense_Mutation_p.R41S	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	25					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ATCGCGTCTTCGCCAGGAGGA	0.522000													4	4					1.23904e-05	1.5031e-05	0.014758	1	0
POM121L9P	29774	broad.mit.edu	37	22	24659512	24659512	+	RNA	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:24659512A>G	ENST00000414583.2	+	0	3037					NR_003714.1																						TGCCTGGGCCATGGAGCACTC	0.473000													4	13					0	0	0.009096	0	0
MMP8	4317	broad.mit.edu	37	11	102584511	102584511	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:102584511T>G	ENST00000236826.3	-	9	1366	c.1268A>C	c.(1267-1269)aAa>aCa	p.K423T		NM_002424.2	NP_002415.1	P22894	MMP8_HUMAN	matrix metallopeptidase 8 (neutrophil collagenase)	423					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(4)|skin(6)|stomach(1)|urinary_tract(1)	32	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		TGCATCAACTTTACTCTCTAT	0.358000													12	56					0	0	0.146539	0	0
C11orf74	119710	broad.mit.edu	37	11	36680708	36680708	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:36680708G>T	ENST00000334307.5	+	6	753	c.638G>T	c.(637-639)aGc>aTc	p.S213I	C11orf74_ENST00000347206.4_Missense_Mutation_p.S139I|C11orf74_ENST00000534635.1_Missense_Mutation_p.S139I|C11orf74_ENST00000446510.2_Intron	NM_138787.2	NP_620142.2	Q86VG3	CK074_HUMAN	chromosome 11 open reading frame 74	213										breast(1)|kidney(1)|large_intestine(1)|lung(5)	8	all_lung(20;0.226)	all_hematologic(20;0.0118)				AAGGACACCAGCCCAGACTTA	0.378000													7	71					0.00307968	0.00338879	0.038147	1	0
AIFM1	9131	broad.mit.edu	37	X	129264138	129264138	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:129264138G>T	ENST00000287295.3	-	15	1807	c.1577C>A	c.(1576-1578)aCt>aAt	p.T526N	AIFM1_ENST00000319908.3_Missense_Mutation_p.T522N|AIFM1_ENST00000440263.1_Missense_Mutation_p.T174N|AIFM1_ENST00000346424.2_Missense_Mutation_p.T239N|AIFM1_ENST00000460436.2_Missense_Mutation_p.T187N|AIFM1_ENST00000535724.1_3'UTR	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	526					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						TCGGATACCAGTTCCTGTGGC	0.502000													13	128					7.93312e-07	1.01654e-06	0.119110	1	0
CSMD1	64478	broad.mit.edu	37	8	2830776	2830776	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:2830776C>T	ENST00000520002.1	-	58	9344	c.8789G>A	c.(8788-8790)gGg>gAg	p.G2930E	CSMD1_ENST00000602723.1_Missense_Mutation_p.G2872E|CSMD1_ENST00000602557.1_Missense_Mutation_p.G2930E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G2872E|CSMD1_ENST00000542608.1_Missense_Mutation_p.G2871E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G2929E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2930	Sushi 22.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AAGCCGAGACCCATGTGCTGG	0.493000													39	66					0	0	0.124865	0	0
CRLF2	64109	broad.mit.edu	37	X	1321326	1321326	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:1321326G>C	ENST00000381567.3	-	4	428	c.429C>G	c.(427-429)taC>taG	p.Y143*	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Nonsense_Mutation_p.Y143*	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	143	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GGAGATCCCCGTAGGACAGGT	0.592000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								18	62					0	0	0.049695	0	0
PHF3	23469	broad.mit.edu	37	6	64408494	64408494	+	Splice_Site	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:64408494A>G	ENST00000262043.3	+	8	3321	c.2982_splice	c.e8+1	p.N994_splice	PHF3_ENST00000393387.1_Splice_Site_p.N994_splice			Q92576	PHF3_HUMAN	PHD finger protein 3	994	TFIIS central.				multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CCTAAAAACAATGTAAGTATG	0.284000													14	25					0	0	0.132662	0	0
CCR1	1230	broad.mit.edu	37	3	46245043	46245043	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:46245043G>T	ENST00000296140.3	-	2	887	c.762C>A	c.(760-762)ccC>ccA	p.P254P	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	254					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TCAAATTGTAGGGGGTCCAAA	0.413000													21	64					4.35082e-09	6.28215e-09	0.055883	1	0
BAGE2	85319	broad.mit.edu	37	21	11039233	11039233	+	RNA	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:11039233C>A	ENST00000470054.1	-	0	970									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTTGGATACCACTGTTTTAG	0.403000													13	249					9.31168e-06	1.14368e-05	0.105934	1	0
URB2	9816	broad.mit.edu	37	1	229772543	229772543	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:229772543G>T	ENST00000258243.2	+	4	2319	c.2183G>T	c.(2182-2184)gGg>gTg	p.G728V		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	728						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GGCCAAGTTGGGATGGTGAGT	0.468000													16	105					4.7546e-09	6.79885e-09	0.146539	1	0
CMC4	100272147	broad.mit.edu	37	X	154292295	154292295	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:154292295G>T	ENST00000369484.3	-	2	682	c.4C>A	c.(4-6)Ccg>Acg	p.P2T	CMC4_ENST00000369479.1_Missense_Mutation_p.P2T	NM_001018024.2	NP_001018024.1			C-x(9)-C motif containing 4																		TCCTTCTGCGGCATATCCAGA	0.338000													5	96					0.014758	0.015885	0.014758	1	0
KCNA4	3739	broad.mit.edu	37	11	30033380	30033380	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:30033380C>G	ENST00000328224.6	-	2	2079	c.846G>C	c.(844-846)agG>agC	p.R282S		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	282						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity	p.R282R(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CGGGGAGGGCCCTGTCTTCCT	0.512000													20	130					0	0	0.049695	0	0
PCDH11X	27328	broad.mit.edu	37	X	91642767	91642767	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:91642767G>T	ENST00000373094.1	+	5	4023	c.3178G>T	c.(3178-3180)Ggc>Tgc	p.G1060C	PCDH11X_ENST00000373097.1_Missense_Mutation_p.G1050C|PCDH11X_ENST00000361655.2_Missense_Mutation_p.G1050C|PCDH11X_ENST00000298274.8_Missense_Mutation_p.G1023C|PCDH11X_ENST00000373088.1_Missense_Mutation_p.G1023C|PCDH11X_ENST00000406881.1_Missense_Mutation_p.G1060C|PCDH11X_ENST00000504220.1_Intron	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1060					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCTGCCAGAAGGCTCTCAGGA	0.498000													19	42					4.96729e-08	6.71378e-08	0.049695	1	0
FOXP2	93986	broad.mit.edu	37	7	114282499	114282499	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:114282499G>T	ENST00000393500.3	+	13	1405	c.585G>T	c.(583-585)tgG>tgT	p.W195C	FOXP2_ENST00000378237.3_Missense_Mutation_p.W270C|FOXP2_ENST00000393494.2_Missense_Mutation_p.W270C|FOXP2_ENST00000360232.4_Missense_Mutation_p.W270C|FOXP2_ENST00000350908.4_Missense_Mutation_p.W270C|FOXP2_ENST00000408937.3_Missense_Mutation_p.W295C|FOXP2_ENST00000403559.4_Missense_Mutation_p.W287C|FOXP2_ENST00000390668.3_Missense_Mutation_p.W294C|FOXP2_ENST00000393498.2_Missense_Mutation_p.W249C|FOXP2_ENST00000393489.3_Missense_Mutation_p.W178C|FOXP2_ENST00000393491.3_Missense_Mutation_p.W178C			O15409	FOXP2_HUMAN	forkhead box P2	270	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						AGCAGTTATGGAAAGAAGTGA	0.403000													15	52					2.31682e-05	2.78772e-05	0.132662	1	0
MYCBPAP	84073	broad.mit.edu	37	17	48586035	48586035	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:48586035C>T	ENST00000323776.5	+	1	291	c.129C>T	c.(127-129)acC>acT	p.T43T	MYCBPAP_ENST00000419930.1_Silent_p.T43T|MYCBPAP_ENST00000436259.2_Silent_p.T6T	NM_032133.4	NP_115509.4	Q8TBZ2	MYBPP_HUMAN	MYCBP associated protein	6					cell differentiation|multicellular organismal development|spermatogenesis|synaptic transmission	cytoplasm|membrane	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(8)|ovary(4)|pancreas(1)|skin(2)|urinary_tract(2)	31	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;1.23e-09)			CGGGCGGCACCATGAAGTCTC	0.627000													8	11					0	0	0.038147	0	0
AE000661.37	0	broad.mit.edu	37	14	22891771	22891771	+	RNA	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:22891771A>G	ENST00000514473.2	-	0	225				AE000661.37_ENST00000545670.1_RNA|AE000661.37_ENST00000535351.1_RNA|TRDV2_ENST00000390469.2_RNA|AE000661.37_ENST00000537850.1_RNA|AE000661.37_ENST00000541008.1_RNA																							CCTGAACACCAAACAGTGCCT	0.522000													41	86					0	0	0.098360	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821878	5821878	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:5821878C>A	ENST00000381095.3	-	5	1468	c.841G>T	c.(841-843)Ggc>Tgc	p.G281C	NLGN4X_ENST00000381093.2_Missense_Mutation_p.G301C|NLGN4X_ENST00000381092.1_Missense_Mutation_p.G281C|NLGN4X_ENST00000538097.1_Missense_Mutation_p.G281C|NLGN4X_ENST00000275857.6_Missense_Mutation_p.G281C	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	281					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AGGGCGGTGCCGCTCTGAATG	0.532000													5	40					0.00307968	0.00338879	0.038147	1	0
GLI3	2737	broad.mit.edu	37	7	42005508	42005508	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:42005508C>A	ENST00000395925.3	-	15	3247	c.3163G>T	c.(3163-3165)Ggc>Tgc	p.G1055C	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1055					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						CGGGACTGGCCGCCCTCGGGC	0.652000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				13	22					4.36969e-10	6.40311e-10	0.105934	1	0
PTCHD2	57540	broad.mit.edu	37	1	11585275	11585275	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:11585275G>T	ENST00000294484.6	+	12	2657	c.2519G>T	c.(2518-2520)gGc>gTc	p.G840V	PTCHD2_ENST00000389575.3_Missense_Mutation_p.G840V	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	840					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AAGAGTCAAGGCCACCCCGCT	0.577000													9	28					1.76689e-08	2.46698e-08	0.058154	1	0
UPF1	5976	broad.mit.edu	37	19	18971211	18971211	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:18971211A>T	ENST00000262803.5	+	16	2536	c.2264A>T	c.(2263-2265)gAg>gTg	p.E755V	UPF1_ENST00000599848.1_Missense_Mutation_p.E766V	NM_002911.3	NP_002902.2	Q92900	RENT1_HUMAN	UPF1 regulator of nonsense transcripts homolog (yeast)	766					cell cycle|DNA repair|DNA replication|histone mRNA catabolic process|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational termination	chromatin|cytoplasmic mRNA processing body|exon-exon junction complex	ATP binding|ATP-dependent RNA helicase activity|chromatin binding|DNA binding|protein binding|RNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40						CAGGGCCAAGAGGAGATTGCC	0.587000													14	32					0	0	0.132662	0	0
SIRT2	22933	broad.mit.edu	37	19	39372103	39372103	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:39372103C>A	ENST00000249396.7	-	10	961	c.660G>T	c.(658-660)aaG>aaT	p.K220N	SIRT2_ENST00000358931.5_Missense_Mutation_p.K220N|SIRT2_ENST00000392081.2_Missense_Mutation_p.K183N	NM_012237.3	NP_036369.2	Q8IXJ6	SIRT2_HUMAN	sirtuin 2	220	Deacetylase sirtuin-type.				cell division|chromatin silencing at rDNA|chromatin silencing at telomere|mitosis|negative regulation of striated muscle tissue development|protein ADP-ribosylation|regulation of exit from mitosis|regulation of phosphorylation|response to redox state	chromatin silencing complex|cytoplasm|microtubule	histone acetyltransferase binding|histone deacetylase binding|NAD+ binding|NAD-dependent histone deacetylase activity|transcription factor binding|tubulin deacetylase activity|ubiquitin binding|zinc ion binding			endometrium(1)|large_intestine(2)|lung(5)|skin(1)	9	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00125)|LUSC - Lung squamous cell carcinoma(53;0.00191)			AGTCTTCACACTTGGGCGTCA	0.617000													15	26					2.62699e-14	4.02896e-14	0.132662	1	0
PRUNE2	158471	broad.mit.edu	37	9	79322001	79322001	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:79322001G>T	ENST00000428286.1	-	8	5312	c.4112C>A	c.(4111-4113)gCt>gAt	p.A1371D	PRUNE2_ENST00000376718.3_Missense_Mutation_p.A1730D			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1730					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTTAGGATCAGCTGTGACCAA	0.428000													16	44					1.02788e-11	1.54443e-11	0.033300	1	0
SEMA6C	10500	broad.mit.edu	37	1	151107786	151107786	+	Splice_Site	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:151107786C>A	ENST00000341697.3	-	15	3125		c.e15-1					Q9H3T2	SEM6C_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C							integral to membrane	receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	28	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCACTGCACCTAGGGTGAGG	0.547000													22	45					1.37657e-19	2.23881e-19	0.062417	1	0
MCM10	55388	broad.mit.edu	37	10	13237238	13237238	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:13237238C>A	ENST00000378694.1	+	13	2018	c.1943C>A	c.(1942-1944)cCa>cAa	p.P648Q	MCM10_ENST00000484800.2_Missense_Mutation_p.P649Q|MCM10_ENST00000378714.3_Missense_Mutation_p.P648Q			Q7L590	MCM10_HUMAN	minichromosome maintenance complex component 10	649					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle	nucleoplasm	metal ion binding|protein binding			central_nervous_system(1)|large_intestine(4)|ovary(2)|skin(1)|stomach(1)	9						CCACCAAGACCAAAACTGAGT	0.502000													3	34					0.004672	0.005103	0.115264	1	0
LRRC4C	57689	broad.mit.edu	37	11	40136613	40136613	+	Silent	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:40136613C>A	ENST00000278198.2	-	2	3193	c.1230G>T	c.(1228-1230)acG>acT	p.T410T	LRRC4C_ENST00000530763.1_Silent_p.T410T|LRRC4C_ENST00000527150.1_Silent_p.T410T|LRRC4C_ENST00000528697.1_Silent_p.T410T			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	410	Ig-like C2-type.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TGAAATTTAACGTACCATCAC	0.443000													20	140					5.03518e-11	7.45207e-11	0.043863	1	0
AFF2	2334	broad.mit.edu	37	X	147743992	147743992	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:147743992G>A	ENST00000370460.2	+	3	1223	c.744G>A	c.(742-744)gcG>gcA	p.A248A	AFF2_ENST00000342251.3_Silent_p.A244A|AFF2_ENST00000370457.5_Silent_p.A244A|AFF2_ENST00000370458.1_Silent_p.A244A	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	248					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CCGTGCAAGCGCCTGGGTCTC	0.473000													20	357					0	0	0.091800	0	0
RANBP2	5903	broad.mit.edu	37	2	109380884	109380884	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:109380884A>T	ENST00000283195.6	+	20	4015	c.3889A>T	c.(3889-3891)Aag>Tag	p.K1297*		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	1297	RanBD1 1.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TTTTAAATGCAAGTTTGAAGA	0.413000													22	48					0	0	0.069288	0	0
MTTP	4547	broad.mit.edu	37	4	100532328	100532328	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:100532328A>G	ENST00000457717.1	+	14	2054	c.1798A>G	c.(1798-1800)Atg>Gtg	p.M600V	MTTP_ENST00000265517.5_Missense_Mutation_p.M600V|RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000511045.1_Missense_Mutation_p.M627V	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	600	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TCTGAAGGAAATGGTCGCTCA	0.408000													14	53					0	0	0.132662	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418309	105418309	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:105418309T>A	ENST00000333244.5	-	7	3598	c.3479A>T	c.(3478-3480)gAc>gTc	p.D1160V	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1160						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAACCTGCTGTCTTTGGCAGT	0.627000													17	39					0	0	0.069288	0	0
WASH3P	374666	broad.mit.edu	37	15	102516473	102516473	+	RNA	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:102516473G>A	ENST00000557932.1	+	0	1421																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						ATCCTAGGGGGCTCCATGACA	0.642000													3	13					0	0	0.009096	0	0
ZNF382	84911	broad.mit.edu	37	19	37117340	37117340	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:37117340C>T	ENST00000435416.1	+	3	2033	c.538C>T	c.(538-540)Cct>Tct	p.P180S	ZNF382_ENST00000423582.1_Missense_Mutation_p.P132S|ZNF382_ENST00000439428.1_Missense_Mutation_p.P180S|ZNF382_ENST00000292928.2_Missense_Mutation_p.P181S			Q96SR6	ZN382_HUMAN	zinc finger protein 382	181	Represses transcription (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GAAAATTCATCCTGCAGTGAA	0.403000													27	80					0	0	0.108266	0	0
SH3TC1	54436	broad.mit.edu	37	4	8217932	8217932	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:8217932T>A	ENST00000539824.1	+	6	722	c.348T>A	c.(346-348)caT>caA	p.H116Q	SH3TC1_ENST00000245105.3_Missense_Mutation_p.H192Q			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	192							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TCCAAGTCCATGTGGATGAGA	0.597000													5	17					0	0	0.029380	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24909728	24909728	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:24909728C>T	ENST00000396432.2	-	9	1582	c.1096G>A	c.(1096-1098)Gtg>Atg	p.V366M	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.V153M	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	365					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GGAGCCTCCACAGCTTGAGAT	0.413000													20	59					0	0	0.055883	0	0
ANK2	287	broad.mit.edu	37	4	114232510	114232510	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:114232510G>T	ENST00000357077.4	+	24	2701	c.2648G>T	c.(2647-2649)gGt>gTt	p.G883V	ANK2_ENST00000264366.6_Missense_Mutation_p.G883V|ANK2_ENST00000394537.3_Missense_Mutation_p.G883V|ANK2_ENST00000509550.1_Missense_Mutation_p.G92V|ANK2_ENST00000506722.1_Missense_Mutation_p.G862V	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	883					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TTCCTGGATGGTATGAATTAC	0.448000													5	78					5.9392e-07	7.74451e-07	0.021553	1	0
PTPRB	5787	broad.mit.edu	37	12	70949687	70949687	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:70949687G>T	ENST00000334414.6	-	19	5000	c.4956C>A	c.(4954-4956)agC>agA	p.S1652R	PTPRB_ENST00000550358.1_Missense_Mutation_p.S1564R|PTPRB_ENST00000550857.1_Missense_Mutation_p.S1344R|PTPRB_ENST00000538708.1_Missense_Mutation_p.S1344R|PTPRB_ENST00000451516.2_Missense_Mutation_p.S1344R|PTPRB_ENST00000261266.5_Missense_Mutation_p.S1434R	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1434					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAACCACCTCGCTGGTCATGC	0.527000													31	117					2.47316e-13	3.77348e-13	0.059317	1	0
N6AMT2	221143	broad.mit.edu	37	13	21306050	21306050	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr13:21306050C>T	ENST00000382758.1	-	4	485	c.438G>A	c.(436-438)tcG>tcA	p.S146S	N6AMT2_ENST00000382754.4_Silent_p.S146S			Q8WVE0	N6MT2_HUMAN	N-6 adenine-specific DNA methyltransferase 2 (putative)	146							methyltransferase activity|nucleic acid binding			endometrium(1)|large_intestine(3)|lung(3)	7		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		GACATTCCTCCGAAAGATAGG	0.423000													3	24					0	0	0.009096	0	0
EPHA5	2044	broad.mit.edu	37	4	66361218	66361218	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:66361218G>C	ENST00000273854.3	-	4	1554	c.954C>G	c.(952-954)agC>agG	p.S318R	EPHA5_ENST00000432638.2_Intron|EPHA5_ENST00000354839.4_Missense_Mutation_p.S318R|EPHA5_ENST00000511294.1_Missense_Mutation_p.S318R	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	318	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ATTTGCCGCAGCTCTGGATGT	0.453000										TSP Lung(17;0.13)			11	105					0	0	0.080935	0	0
SLIT3	6586	broad.mit.edu	37	5	168123402	168123402	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:168123402A>T	ENST00000519560.1	-	28	3396	c.2977T>A	c.(2977-2979)Tgt>Agt	p.C993S	SLIT3_ENST00000404867.3_Missense_Mutation_p.C993S|SLIT3_ENST00000332966.8_Missense_Mutation_p.C1000S	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	993	EGF-like 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGATCTCACACCGCTGCCCC	0.582000													21	31					0	0	0.062417	0	0
RYR2	6262	broad.mit.edu	37	1	237993849	237993849	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:237993849G>T	ENST00000366574.2	+	103	14992	c.14675G>T	c.(14674-14676)gGg>gTg	p.G4892V	RYR2_ENST00000360064.6_Missense_Mutation_p.G4898V|RYR2_ENST00000462585.1_3'UTR|RYR2_ENST00000542537.1_Missense_Mutation_p.G4876V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4892					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCATCTGTGGGATAGGCAAT	0.438000													21	352					2.44723e-14	3.77281e-14	0.099896	1	0
CNTNAP2	26047	broad.mit.edu	37	7	148080944	148080944	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:148080944G>A	ENST00000361727.3	+	22	4195	c.3679G>A	c.(3679-3681)Gcc>Acc	p.A1227T	CNTNAP2_ENST00000538075.1_Missense_Mutation_p.A286T|CNTNAP2_ENST00000463592.2_3'UTR	NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	1227			A -> T.		behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CATGTCGTCCGCCACCGACCC	0.592000										HNSCC(39;0.1)			9	16					0	0	0.069234	0	0
SVILP1	645954	broad.mit.edu	37	10	30986357	30986357	+	RNA	SNP	T	T	C	rs117915096	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:30986357T>C	ENST00000435645.1	+	0	347																											CGGCGCTCAATAGTGGGGACT	0.552000													3	27					0	0	0.115264	0	0
UNC45B	146862	broad.mit.edu	37	17	33496891	33496891	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:33496891C>G	ENST00000268876.5	+	11	1585	c.1488C>G	c.(1486-1488)gaC>gaG	p.D496E	UNC45B_ENST00000433649.1_Missense_Mutation_p.D496E|UNC45B_ENST00000378449.1_Intron|UNC45B_ENST00000591048.1_Intron|UNC45B_ENST00000394570.2_Missense_Mutation_p.D496E	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	496			D -> H (in a breast cancer sample; somatic mutation).		cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				GTGGCACAGACTACGGTCTCA	0.572000													14	30					0	0	0.146539	0	0
SPTBN5	51332	broad.mit.edu	37	15	42147101	42147101	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:42147101C>A	ENST00000320955.6	-	56	9724	c.9497G>T	c.(9496-9498)aGg>aTg	p.R3166M		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3166					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TGCCAACTTCCTCAGGGCATA	0.597000													6	23					8.12818e-05	9.58543e-05	0.029380	1	0
VIT	5212	broad.mit.edu	37	2	37041396	37041396	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:37041396C>T	ENST00000379242.3	+	16	2276	c.1974C>T	c.(1972-1974)ccC>ccT	p.P658P	VIT_ENST00000389975.3_Silent_p.P643P|VIT_ENST00000404084.1_Silent_p.P595P|VIT_ENST00000401530.1_Silent_p.P622P|VIT_ENST00000379241.3_Silent_p.P621P|VIT_ENST00000497382.1_Silent_p.P312P	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	643	VWFA 2.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				CCACTCACCCCGCCAGAGACC	0.512000													20	29					0	0	0.069288	0	0
LY9	4063	broad.mit.edu	37	1	160783558	160783558	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:160783558C>A	ENST00000263285.5	+	3	617	c.587C>A	c.(586-588)cCc>cAc	p.P196H	LY9_ENST00000368041.2_Missense_Mutation_p.P156H|LY9_ENST00000368040.1_5'UTR|LY9_ENST00000341032.4_Missense_Mutation_p.P196H|LY9_ENST00000471816.1_3'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	196	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CCAAGGGAACCCCATGCTTCT	0.537000													45	143					2.61675e-31	4.42605e-31	0.131918	1	0
POM121L2	94026	broad.mit.edu	37	6	27278743	27278743	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:27278743G>T	ENST00000444565.1	-	1	1206	c.1207C>A	c.(1207-1209)Cct>Act	p.P403T	POM121L2_ENST00000377451.2_Intron	NM_033482.3	NP_258443.2	C9J1I7	C9J1I7_HUMAN	POM121 transmembrane nucleoporin-like 2	403										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	7						TCCAACTGAGGATTTGCTCCC	0.498000													5	11					0.000602214	0.000688245	0.014758	1	0
MED12L	116931	broad.mit.edu	37	3	151085515	151085515	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:151085515G>A	ENST00000474524.1	+	22	3342	c.3304G>A	c.(3304-3306)Gtc>Atc	p.V1102I	MED12L_ENST00000273432.4_Missense_Mutation_p.V962I|P2RY12_ENST00000302632.3_Intron	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1102					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CCTGGAGGACGTCGTGCAGCA	0.448000													67	83					0	0	0.139131	0	0
FRMPD4	9758	broad.mit.edu	37	X	12722558	12722558	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:12722558C>T	ENST00000380682.1	+	11	1657	c.1151C>T	c.(1150-1152)tCa>tTa	p.S384L		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	384	FERM.				positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						AAAGCACTTTCACACCTTGTC	0.368000													6	148					0	0	0.029380	0	0
SLC24A5	283652	broad.mit.edu	37	15	48426633	48426633	+	Splice_Site	SNP	T	T	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:48426633T>C	ENST00000341459.3	+	4	460	c.385_splice	c.e4-1	p.G129_splice	SLC24A5_ENST00000449382.2_Splice_Site_p.G69_splice	NM_205850.2	NP_995322.1	Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	129					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		TGCACATAGGTGTATTTATCA	0.368000													14	69					0	0	0.146539	0	0
SLC22A14	9389	broad.mit.edu	37	3	38355272	38355272	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:38355272C>T	ENST00000273173.4	+	7	1309	c.1218C>T	c.(1216-1218)ggC>ggT	p.G406G	SLC22A14_ENST00000448498.1_Silent_p.G406G	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	406						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		GAGAGCTGGGCGTGAGCGTCC	0.582000													22	105					0	0	0.069288	0	0
RERE	473	broad.mit.edu	37	1	8674657	8674657	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:8674657G>A	ENST00000337907.3	-	5	1119	c.485C>T	c.(484-486)cCa>cTa	p.P162L	RERE_ENST00000400907.2_Missense_Mutation_p.P162L|RERE_ENST00000400908.2_Missense_Mutation_p.P162L	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	162	BAH.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AAGATGCTGTGGTGGCTGTGA	0.488000													12	118					0	0	0.132662	0	0
CFLAR	8837	broad.mit.edu	37	2	202000805	202000805	+	Silent	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:202000805A>G	ENST00000395148.2	+	4	710	c.498A>G	c.(496-498)acA>acG	p.T166T	CFLAR_ENST00000494258.1_Silent_p.T70T|CFLAR_ENST00000443227.1_Silent_p.T70T|CFLAR_ENST00000340870.5_Silent_p.T166T|CFLAR_ENST00000355558.4_Silent_p.T166T|CFLAR_ENST00000341222.6_Silent_p.T166T|CFLAR_ENST00000479953.2_Silent_p.T70T|CFLAR_ENST00000309955.2_Silent_p.T166T|CFLAR_ENST00000457277.1_Silent_p.T166T|CFLAR_ENST00000341582.6_Silent_p.T166T|CFLAR_ENST00000342795.5_Silent_p.T166T|CFLAR_ENST00000440180.1_Silent_p.T166T|CFLAR_ENST00000423241.2_Silent_p.T166T			O15519	CFLAR_HUMAN	CASP8 and FADD-like apoptosis regulator	166	DED 2.|Interaction with FADD.|Interaction with caspase-8 propeptide.|Interaction with caspase-8.|Not proteolytically processed and involved in apoptosis inhibition.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis		cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|stomach(1)	13						ACCTGAAGACAAAAATCCAGA	0.423000													22	58					0	0	0.069288	0	0
CRLF2	64109	broad.mit.edu	37	X	1321328	1321328	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:1321328A>T	ENST00000381567.3	-	4	426	c.427T>A	c.(427-429)Tac>Aac	p.Y143N	CRLF2_ENST00000467626.1_5'UTR|CRLF2_ENST00000381566.1_Missense_Mutation_p.Y143N	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	143	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AGATCCCCGTAGGACAGGTCA	0.587000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								19	66					0	0	0.055883	0	0
TTC40	54777	broad.mit.edu	37	10	134664757	134664757	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:134664757C>A	ENST00000368586.5	-	40	5727	c.5627G>T	c.(5626-5628)gGc>gTc	p.G1876V	TTC40_ENST00000263170.5_Missense_Mutation_p.G37V	NM_001200049.2	NP_001186978.2	Q8IYW2	CJ092_HUMAN	tetratricopeptide repeat domain 40	37										breast(1)|endometrium(5)|lung(19)|urinary_tract(3)	28						TTCCACGAGGCCGAGCTTGAG	0.612000													9	14					3.09899e-07	4.07689e-07	0.047766	1	0
PAX6	5080	broad.mit.edu	37	11	31815051	31815051	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:31815051T>G	ENST00000419022.1	-	12	1477	c.1009A>C	c.(1009-1011)Aca>Cca	p.T337P	PAX6_ENST00000379115.4_Missense_Mutation_p.T337P|PAX6_ENST00000379123.5_Missense_Mutation_p.T323P|PAX6_ENST00000379129.2_Missense_Mutation_p.T337P|PAX6_ENST00000379107.2_Missense_Mutation_p.T337P|PAX6_ENST00000241001.8_Missense_Mutation_p.T323P|PAX6_ENST00000379111.2_Missense_Mutation_p.T323P|PAX6_ENST00000379132.3_Missense_Mutation_p.T323P	NM_001127612.1|NM_001258462.1|NM_001258463.1	NP_001121084.1|NP_001245391.1|NP_001245392.1	P26367	PAX6_HUMAN	paired box 6	323	Pro/Ser/Thr-rich.				blood vessel development|central nervous system development|cornea development in camera-type eye|glucose homeostasis|iris morphogenesis|negative regulation of neurogenesis|neuron fate commitment|pancreatic A cell development|positive regulation of transcription, DNA-dependent|response to wounding|visual perception	cytoplasm|nuclear chromatin	R-SMAD binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)	35	Lung SC(675;0.225)					TAGGTGTTTGTGAGGGCTGTG	0.557000									Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation				3	66					0	0	0.115264	0	0
GAP43	2596	broad.mit.edu	37	3	115395284	115395284	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:115395284C>G	ENST00000393780.3	+	3	1031	c.563C>G	c.(562-564)cCg>cGg	p.P188R	GAP43_ENST00000305124.6_Missense_Mutation_p.P152R	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	152					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		GATAACTCGCCGTCCTCCAAG	0.617000													9	40					0	0	0.069234	0	0
COL15A1	1306	broad.mit.edu	37	9	101748343	101748343	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:101748343C>T	ENST00000375001.3	+	3	1020	c.597C>T	c.(595-597)agC>agT	p.S199S		NM_001855.3	NP_001846.3	P39059	COFA1_HUMAN	collagen, type XV, alpha 1	199	TSP N-terminal.				angiogenesis|cell differentiation|signal transduction	collagen type XV|extracellular space|integral to membrane	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(20)|liver(1)|lung(42)|ovary(6)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	107		Acute lymphoblastic leukemia(62;0.0562)				TTGAGTCCAGCGCTGGAATCT	0.557000													6	68					0	0	0.021553	0	0
CDH9	1007	broad.mit.edu	37	5	26881506	26881506	+	Silent	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:26881506A>T	ENST00000231021.4	-	12	2281	c.2109T>A	c.(2107-2109)acT>acA	p.T703T		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	703					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ACAGAGGCACAGTCCTCCTTA	0.408000													21	73					0	0	0.062417	0	0
SASH1	23328	broad.mit.edu	37	6	148808849	148808849	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:148808849A>G	ENST00000367467.3	+	8	1202	c.727A>G	c.(727-729)Aat>Gat	p.N243D		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	243							protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ATCAAACTGCAATGTGAGTTT	0.488000													12	67					0	0	0.080935	0	0
STPG2	285555	broad.mit.edu	37	4	98762072	98762072	+	Silent	SNP	C	C	A	rs149484886	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:98762072C>A	ENST00000295268.3	-	9	1145	c.1056G>T	c.(1054-1056)gcG>gcT	p.A352A	STPG2_ENST00000506482.1_Intron	NM_174952.2	NP_777612.1			sperm-tail PG-rich repeat containing 2																		AGCTGCCTGGCGCTGGAATAA	0.348000													17	32					8.34094e-07	1.06419e-06	0.049695	1	0
TSC22D4	81628	broad.mit.edu	37	7	100075243	100075243	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:100075243G>C	ENST00000300181.2	-	2	1173	c.419C>G	c.(418-420)cCa>cGa	p.P140R	TSC22D4_ENST00000393991.1_Intron	NM_030935.3	NP_112197.1	Q9Y3Q8	T22D4_HUMAN	TSC22 domain family, member 4	140					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GCCTGACGGTGGGGTGGGGGC	0.711000													5	9					0	0	0.029380	0	0
CSMD3	114788	broad.mit.edu	37	8	113364659	113364659	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:113364659C>A	ENST00000297405.5	-	39	6485	c.6241G>T	c.(6241-6243)Gga>Tga	p.G2081*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.G1977*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.G2011*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.G2041*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2081	Sushi 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGAGAATATCCTTGATCACAC	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	39					1.49906e-05	1.81111e-05	0.119110	1	0
NRXN1	9378	broad.mit.edu	37	2	50699567	50699567	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:50699567G>C	ENST00000404971.1	-	17	4572	c.3233C>G	c.(3232-3234)tCc>tGc	p.S1078C	NRXN1_ENST00000402717.3_Missense_Mutation_p.S1030C|NRXN1_ENST00000405472.3_Missense_Mutation_p.S1030C|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401710.1_Missense_Mutation_p.S47C|NRXN1_ENST00000401669.2_Missense_Mutation_p.S1038C|NRXN1_ENST00000406859.3_Missense_Mutation_p.S1038C|NRXN1_ENST00000406316.2_Missense_Mutation_p.S1038C	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1038	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TTTTGGTAAGGATTTGTATGT	0.403000													12	60					0	0	0.080935	0	0
LPAL2	80350	broad.mit.edu	37	6	160932105	160932105	+	RNA	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:160932105G>C	ENST00000335388.5	-	0	51					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		ACTTACATGAGAGTAAACGCA	0.428000													23	86					0	0	0.099896	0	0
KEAP1	9817	broad.mit.edu	37	19	10602334	10602334	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:10602334C>T	ENST00000171111.5	-	3	1791	c.1244G>A	c.(1243-1245)cGc>cAc	p.R415H	KEAP1_ENST00000393623.2_Missense_Mutation_p.R415H	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CACCCCGATGCGGTTACGGGG	0.657000													10	7					0	0	0.093190	0	0
TENM1	10178	broad.mit.edu	37	X	123785893	123785893	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:123785893G>C	ENST00000422452.2	-	8	1513	c.1450C>G	c.(1450-1452)Cgg>Ggg	p.R484G	TENM1_ENST00000371130.3_Missense_Mutation_p.R484G	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ATCAGGTTCCGAGGGGAGTGC	0.423000													6	87					0	0	0.021553	0	0
KCNA2	3737	broad.mit.edu	37	1	111146103	111146103	+	Silent	SNP	G	G	A	rs141901988		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:111146103G>A	ENST00000485317.1	-	3	1975	c.1302C>T	c.(1300-1302)agC>agT	p.S434S	KCNA2_ENST00000369770.3_Intron|KCNA2_ENST00000440270.1_Silent_p.S434S|KCNA2_ENST00000316361.4_Silent_p.S434S			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	434						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TCTTTGGACAGCTTGTCACTT	0.468000													13	58					0	0	0.119110	0	0
C4orf19	55286	broad.mit.edu	37	4	37591710	37591710	+	Splice_Site	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:37591710C>T	ENST00000284437.6	+	3	211	c.32_splice	c.e3-1	p.S11_splice	C4orf19_ENST00000508175.1_Intron|C4orf19_ENST00000381980.4_Splice_Site_p.S11_splice	NM_018302.2	NP_060772.2	Q8IY42	CD019_HUMAN	chromosome 4 open reading frame 19	11										large_intestine(1)|lung(3)|skin(3)|stomach(1)|urinary_tract(1)	9						TTTCCTGAAGCTATCTCTTTG	0.408000													41	160					0	0	0.111260	0	0
PLOD2	5352	broad.mit.edu	37	3	145796987	145796987	+	Silent	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:145796987G>C	ENST00000282903.5	-	13	1593	c.1416C>G	c.(1414-1416)ctC>ctG	p.L472L	RP11-274H2.2_ENST00000480247.1_RNA|PLOD2_ENST00000461497.1_Silent_p.L132L|PLOD2_ENST00000494950.1_Silent_p.L417L|PLOD2_ENST00000360060.3_Silent_p.L472L	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	472					protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	TCTCTGATCGGAGTGTCTTTC	0.358000													10	65					0	0	0.058154	0	0
HOXD8	3234	broad.mit.edu	37	2	176995617	176995617	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:176995617C>A	ENST00000313173.4	+	1	1150	c.523C>A	c.(523-525)Cac>Aac	p.H175N	HOXD8_ENST00000548663.1_Missense_Mutation_p.H71N|HOXD8_ENST00000544999.1_Missense_Mutation_p.H175N|HOXD8_ENST00000450510.2_Missense_Mutation_p.H175N|HOXD-AS2_ENST00000440016.2_RNA|HOXD8_ENST00000429017.1_5'UTR	NM_001199746.1|NM_019558.3	NP_001186675.1|NP_062458.1	P13378	HXD8_HUMAN	homeobox D8	175					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(5)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		GGACCCAGACCACTTAAATCA	0.468000													26	81					1.77063e-15	2.75846e-15	0.108266	1	0
CDC42BPA	8476	broad.mit.edu	37	1	227381578	227381578	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:227381578C>A	ENST00000366769.3	-	5	1799	c.508G>T	c.(508-510)Gaa>Taa	p.E170*	CDC42BPA_ENST00000366764.2_Nonsense_Mutation_p.E170*|CDC42BPA_ENST00000535525.1_Nonsense_Mutation_p.E170*|CDC42BPA_ENST00000366765.3_Nonsense_Mutation_p.E170*|CDC42BPA_ENST00000334218.5_Nonsense_Mutation_p.E170*|CDC42BPA_ENST00000366767.3_Nonsense_Mutation_p.E170*|CDC42BPA_ENST00000366766.2_Nonsense_Mutation_p.E170*	NM_003607.3	NP_003598.2	Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	170	Protein kinase.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				AATCTATCTTCAAATTTGCTG	0.353000													16	27					1.56452e-12	2.36275e-12	0.043863	1	0
RGAG4	340526	broad.mit.edu	37	X	71350439	71350439	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:71350439G>T	ENST00000545866.1	-	1	1319	c.952C>A	c.(952-954)Ccg>Acg	p.P318T	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.P318T			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	318										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					CCAGGGAGCGGGATAGGCTTG	0.473000													22	137					9.95505e-16	1.5591e-15	0.069288	1	0
LINC01410	103352539	broad.mit.edu	37	9	66458014	66458014	+	RNA	SNP	T	T	C	rs75891239	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:66458014T>C	ENST00000424345.1	+	0	67																											GGTGCTGCAGTGGCGGATCTT	0.721000													3	19					0	0	0.009096	0	0
FOXK1	221937	broad.mit.edu	37	7	4800711	4800711	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:4800711C>T	ENST00000328914.4	+	8	1713	c.1713C>T	c.(1711-1713)ccC>ccT	p.P571P	FOXK1_ENST00000446823.1_Silent_p.P408P	NM_001037165.1	NP_001032242.1	P85037	FOXK1_HUMAN	forkhead box K1	571					cell differentiation|embryo development|muscle organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;7.43e-15)		AGGAGAAACCCACCATTGCGT	0.642000													4	32					0	0	0.021553	0	0
RBP3	5949	broad.mit.edu	37	10	48388966	48388966	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:48388966C>T	ENST00000224600.4	-	1	2025	c.1912G>A	c.(1912-1914)Gcc>Acc	p.A638T		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	638	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	TCCACCAAGGCCCCCAGGCTT	0.692000													5	17					0	0	0.014758	0	0
TIE1	7075	broad.mit.edu	37	1	43774757	43774757	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:43774757G>A	ENST00000372476.3	+	8	1222	c.1143G>A	c.(1141-1143)gtG>gtA	p.V381V	TIE1_ENST00000441333.2_Intron|TIE1_ENST00000433781.2_Silent_p.V26V	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	381	Ig-like C2-type 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCTTCCCCGTGCGGGGCAGCA	0.622000													23	82					0	0	0.069288	0	0
CXorf64	100130613	broad.mit.edu	37	X	125955279	125955279	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:125955279C>T	ENST00000371125.3	+	2	738	c.658C>T	c.(658-660)Cac>Tac	p.H220Y		NM_001122716.1	NP_001116188.1	B1ATL7	CX064_HUMAN	chromosome X open reading frame 64	220	Pro-rich.																GGGCCCATGCCACCCCATGCA	0.522000													9	14					0	0	0.047766	0	0
KIF21A	55605	broad.mit.edu	37	12	39725586	39725586	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:39725586C>G	ENST00000395670.3	-	22	3478	c.3059G>C	c.(3058-3060)gGt>gCt	p.G1020A	KIF21A_ENST00000361961.3_Missense_Mutation_p.G1007A|KIF21A_ENST00000361418.5_Missense_Mutation_p.G1020A|KIF21A_ENST00000541463.2_Missense_Mutation_p.G984A|KIF21A_ENST00000544797.2_Missense_Mutation_p.G1007A			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1020					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				CAATGTCTCACCTTCTTCCTG	0.393000													25	104					0	0	0.091800	0	0
FBN2	2201	broad.mit.edu	37	5	127636547	127636547	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:127636547C>A	ENST00000508053.1	-	54	7102	c.6128G>T	c.(6127-6129)tGt>tTt	p.C2043F	FBN2_ENST00000262464.4_Missense_Mutation_p.C2043F			P35556	FBN2_HUMAN	fibrillin 2	2043	EGF-like 34; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CCCTGGGGGACAGATGCATCT	0.448000													21	50					1.9806e-07	2.6408e-07	0.069288	1	0
ZNF285	26974	broad.mit.edu	37	19	44892196	44892196	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:44892196G>C	ENST00000330997.4	-	4	275	c.211C>G	c.(211-213)Ctt>Gtt	p.L71V	CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000544719.2_Missense_Mutation_p.L71V|ZNF285_ENST00000591679.1_Missense_Mutation_p.L78V	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						CAGCAATGAAGCACTTCTTGC	0.403000													17	40					0	0	0.038395	0	0
GALNT16	57452	broad.mit.edu	37	14	69798189	69798189	+	Silent	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:69798189C>A	ENST00000337827.4	+	7	1026	c.699C>A	c.(697-699)acC>acA	p.T233T	GALNT16_ENST00000448469.3_Silent_p.T233T|GALNT16_ENST00000553669.1_Silent_p.T233T	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		AGGACCACACCCGCGTGGTGA	0.557000													31	126					5.90632e-09	8.40515e-09	0.050027	1	0
UGT2B10	7365	broad.mit.edu	37	4	69682436	69682436	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:69682436G>C	ENST00000265403.7	+	1	726	c.699G>C	c.(697-699)caG>caC	p.Q233H	UGT2B10_ENST00000458688.2_Intron	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	233					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						AGTGGGATCAGTTTTACAGTG	0.308000													12	32					0	0	0.105934	0	0
GP2	2813	broad.mit.edu	37	16	20329668	20329668	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:20329668G>A	ENST00000302555.5	-	7	1241	c.1092C>T	c.(1090-1092)taC>taT	p.Y364Y	GP2_ENST00000341642.5_Silent_p.Y217Y|GP2_ENST00000381360.5_Silent_p.Y220Y|GP2_ENST00000381362.4_Silent_p.Y367Y			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	367	ZP.					anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CATCCCCTTCGTAAGGATTCG	0.507000													76	264					0	0	0.139131	0	0
TRPC6	7225	broad.mit.edu	37	11	101375222	101375222	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:101375222G>T	ENST00000344327.3	-	2	902	c.478C>A	c.(478-480)Cga>Aga	p.R160R	TRPC6_ENST00000360497.4_Silent_p.R160R|TRPC6_ENST00000348423.4_Silent_p.R160R|TRPC6_ENST00000532133.1_Silent_p.R160R	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	160					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TCCCCAACTCGAGAGAGGTTT	0.448000													16	40					3.52763e-06	4.40582e-06	0.033300	1	0
HOOK3	84376	broad.mit.edu	37	8	42823316	42823316	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:42823316G>T	ENST00000307602.4	+	11	1281	c.1081G>T	c.(1081-1083)Gcc>Tcc	p.A361S		NM_032410.3	NP_115786.1	Q86VS8	HOOK3_HUMAN	hook microtubule-tethering protein 3	361					cytoplasmic microtubule organization|early endosome to late endosome transport|endosome organization|endosome to lysosome transport|Golgi localization|interkinetic nuclear migration|lysosome organization|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome|protein transport	cis-Golgi network|FHF complex|microtubule|pericentriolar material	identical protein binding|microtubule binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	31	Ovarian(28;0.01)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.000105)|Lung NSC(58;0.000419)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.048)|LUSC - Lung squamous cell carcinoma(45;0.114)			GTTAAGAAAGGCCAACGCAGC	0.418000			T	RET	papillary thyroid								15	77					2.32078e-09	3.36741e-09	0.132662	1	0
CYP26A1	1592	broad.mit.edu	37	10	94836933	94836933	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:94836933A>G	ENST00000371531.1	+	7	1537	c.1159A>G	c.(1159-1161)Aca>Gca	p.T387A	CYP26A1_ENST00000394139.1_Missense_Mutation_p.T387A|CYP26A1_ENST00000224356.4_Missense_Mutation_p.T456A	NM_057157.2	NP_476498.1	O43174	CP26A_HUMAN	cytochrome P450, family 26, subfamily A, polypeptide 1	456					negative regulation of retinoic acid receptor signaling pathway|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|oxygen binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Colorectal(252;0.122)				CAAAATATTTACAGTGGAGCT	0.473000													4	17					0	0	0.014758	0	0
IPCEF1	26034	broad.mit.edu	37	6	154544347	154544347	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:154544347G>A	ENST00000265198.4	-	6	429	c.274C>T	c.(274-276)Cct>Tct	p.P92S	OPRM1_ENST00000337049.4_Intron|IPCEF1_ENST00000519344.1_Missense_Mutation_p.P64S|IPCEF1_ENST00000367220.4_Missense_Mutation_p.P93S|IPCEF1_ENST00000422970.2_Missense_Mutation_p.P93S	NM_001130700.1|NM_015553.2	NP_001124172.1|NP_056368.1			interaction protein for cytohesin exchange factors 1											breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	12						GTGAAATCAGGCAGGTTGACA	0.388000													22	45					0	0	0.076483	0	0
PRSS1	5644	broad.mit.edu	37	7	142460823	142460823	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:142460823C>T	ENST00000486171.1	+	6	755	c.738C>T	c.(736-738)gtC>gtT	p.V246V	PRSS1_ENST00000311737.7_Silent_p.V232V			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	232					digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			ACACCAAGGTCTACAACTATG	0.488000													19	64					0	0	0.038395	0	0
JAG1	182	broad.mit.edu	37	20	10621877	10621877	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr20:10621877G>A	ENST00000254958.5	-	24	3447	c.2932C>T	c.(2932-2934)Cac>Tac	p.H978Y	JAG1_ENST00000423891.2_Missense_Mutation_p.H819Y	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	978					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						CTGCAAATGTGCTCCGTAGTA	0.408000									Alagille Syndrome				12	25					0	0	0.080935	0	0
MAGEA11	4110	broad.mit.edu	37	X	148797640	148797640	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:148797640C>A	ENST00000355220.5	+	5	596	c.494C>A	c.(493-495)gCt>gAt	p.A165D	MAGEA11_ENST00000333104.4_Missense_Mutation_p.A136D	NM_005366.4	NP_005357.2	P43364	MAGAB_HUMAN	melanoma antigen family A, 11	165						cytoplasm|nucleus	protein binding			cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|skin(1)	9	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					GAGTTGCCTGCTGCTGAGTCA	0.587000													4	54					0.00909568	0.00986198	0.009096	1	0
PHKA2	5256	broad.mit.edu	37	X	18915323	18915323	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:18915323G>T	ENST00000379942.4	-	30	3905	c.3240C>A	c.(3238-3240)gtC>gtA	p.V1080V		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	1080	Calmodulin-binding (Potential).				glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					ATCCCACGGGGACCCTGTTGA	0.627000													8	44					1.12685e-05	1.3783e-05	0.047766	1	0
OR1M1	125963	broad.mit.edu	37	19	9204125	9204125	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:9204125G>A	ENST00000429566.3	+	1	271	c.205G>A	c.(205-207)Gtt>Att	p.V69I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V69I(2)		breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCTGTCCCTGGTTGATTTCTG	0.557000													4	101					0	0	0.009096	0	0
DCST1	149095	broad.mit.edu	37	1	155011886	155011886	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:155011886G>T	ENST00000295542.1	+	5	366	c.270G>T	c.(268-270)ggG>ggT	p.G90G	DCST1_ENST00000392480.1_Silent_p.G90G|DCST1_ENST00000423025.2_Silent_p.G65G|DCST1_ENST00000368419.2_Silent_p.G90G	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	90						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			CAGGCTTGGGGGCCATGGGCT	0.617000													8	91					1.06961e-07	1.4326e-07	0.038147	1	0
HRNR	388697	broad.mit.edu	37	1	152191897	152191897	+	Silent	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:152191897T>A	ENST00000368801.2	-	3	2283	c.2208A>T	c.(2206-2208)tcA>tcT	p.S736S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	736					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTCCTAGATGACTGTCCTG	0.552000													10	53					0	0	0.080935	0	0
ACKR3	57007	broad.mit.edu	37	2	237489382	237489382	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:237489382T>A	ENST00000272928.3	+	2	584	c.274T>A	c.(274-276)Tgg>Agg	p.W92R		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		TGCCGACCTGTGGGTTGTCCT	0.567000													30	107					0	0	0.050027	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722025	64722025	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:64722025G>C	ENST00000338957.4	+	5	1514	c.1447G>C	c.(1447-1449)Ggt>Cgt	p.G483R	ZC3H12B_ENST00000423889.3_Missense_Mutation_p.G472R	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	472							endonuclease activity|nucleic acid binding|zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CCATGCAGTGGGTGCACTCAA	0.587000													23	252					0	0	0.083992	0	0
GBP5	115362	broad.mit.edu	37	1	89732239	89732239	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:89732239G>C	ENST00000343435.5	-	7	1194	c.658C>G	c.(658-660)Ccc>Gcc	p.P220A	RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000370459.3_Missense_Mutation_p.P220A|GBP5_ENST00000481145.1_5'UTR	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	220						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CACAGACGGGGCAAATTGAAA	0.338000													10	52					0	0	0.080935	0	0
PSG1	5669	broad.mit.edu	37	19	43376074	43376074	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:43376074T>A	ENST00000244296.2	-	3	691	c.554A>T	c.(553-555)cAg>cTg	p.Q185L	PSG1_ENST00000403380.3_Intron|PSG1_ENST00000312439.6_Missense_Mutation_p.Q185L|PSG1_ENST00000595124.1_Intron|PSG1_ENST00000595356.1_Missense_Mutation_p.Q185L|PSG1_ENST00000436291.2_Missense_Mutation_p.Q185L	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				AGGGAGGCTCTGACCATTCAT	0.507000													157	286					0	0	0.139131	0	0
CREG2	200407	broad.mit.edu	37	2	101971757	101971757	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:101971757G>T	ENST00000324768.4	-	3	820	c.683C>A	c.(682-684)tCt>tAt	p.S228Y		NM_153836.3	NP_722578.1	Q8IUH2	CREG2_HUMAN	cellular repressor of E1A-stimulated genes 2	228						extracellular region	FMN binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	10						TTCTTCTGGAGACACTGCGAT	0.393000													8	19					0.00448238	0.00491402	0.047766	1	0
SIGLEC6	946	broad.mit.edu	37	19	52031475	52031475	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:52031475C>A	ENST00000346477.3	-	5	1065	c.997G>T	c.(997-999)Gga>Tga	p.G333*	SIGLEC6_ENST00000391797.3_Intron|SIGLEC6_ENST00000359982.4_Nonsense_Mutation_p.G360*|SIGLEC6_ENST00000436458.1_Nonsense_Mutation_p.G297*|SIGLEC6_ENST00000474054.1_5'UTR|SIGLEC6_ENST00000425629.3_Nonsense_Mutation_p.G349*|SIGLEC6_ENST00000343300.4_Intron	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	349	Ig-like C2-type 2.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CAGACTGCTCCCAGGACACCA	0.502000													18	32					5.03518e-11	7.45207e-11	0.043863	1	0
ACO1	48	broad.mit.edu	37	9	32436254	32436254	+	Silent	SNP	T	T	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:32436254T>C	ENST00000379923.1	+	19	2312	c.2106T>C	c.(2104-2106)acT>acC	p.T702T	ACO1_ENST00000541043.1_Silent_p.T603T|ACO1_ENST00000309951.5_Silent_p.T702T	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	702					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding			breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TTAGCCTAACTCCACGAGAAT	0.428000													5	45					0	0	0.021553	0	0
NALCN	259232	broad.mit.edu	37	13	101728244	101728244	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr13:101728244A>G	ENST00000251127.6	-	35	4015	c.3934T>C	c.(3934-3936)Ttc>Ctc	p.F1312L		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1312						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					CAGATGGAGAAAAACCTAAAT	0.313000													31	65					0	0	0.059317	0	0
MXRA5	25878	broad.mit.edu	37	X	3238059	3238059	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:3238059C>A	ENST00000217939.6	-	5	5821	c.5667G>T	c.(5665-5667)aaG>aaT	p.K1889N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1889	Ig-like C2-type 3.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGTGGAAACCTTTGTCCAAG	0.393000													7	27					0.00198382	0.00220756	0.029380	1	0
EFHB	151651	broad.mit.edu	37	3	19921148	19921148	+	Missense_Mutation	SNP	C	C	A	rs151124981		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:19921148C>A	ENST00000295824.9	-	13	2638	c.2477G>T	c.(2476-2478)cGg>cTg	p.R826L	EFHB_ENST00000344838.4_Missense_Mutation_p.R696L	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	826			R -> W (in dbSNP:rs11917204).		signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						ACACTTGATCCGGTCTGCATG	0.348000													7	81					0.00198382	0.00220756	0.029380	1	0
BIRC6	57448	broad.mit.edu	37	2	32658763	32658763	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:32658763G>T	ENST00000421745.2	+	13	3434	c.3300G>T	c.(3298-3300)atG>atT	p.M1100I		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1100					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					AAGCTTGTATGGTTGGACATG	0.363000													8	43					7.48243e-07	9.67161e-07	0.058154	1	0
ALMS1	7840	broad.mit.edu	37	2	73835701	73835701	+	Splice_Site	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:73835701G>T	ENST00000264448.6	+	22	12570	c.12459_splice	c.e22+1	p.K4153_splice	ALMS1_ENST00000409009.1_Splice_Site_p.K4111_splice	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	4153					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TATATAAAAAGGTCAGTGGGT	0.433000													7	29					8.12818e-05	9.58543e-05	0.029380	1	0
MCM3	4172	broad.mit.edu	37	6	52131450	52131450	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:52131450T>C	ENST00000596288.1	-	15	2279	c.2252A>G	c.(2251-2253)gAc>gGc	p.D751G	MCM3_ENST00000419835.2_Missense_Mutation_p.D660G|MCM3_ENST00000229854.7_Missense_Mutation_p.D706G	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	706					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GTCATAGGGGTCGTATGAATC	0.478000													5	381					0	0	0.014758	0	0
APC	324	broad.mit.edu	37	5	112175871	112175871	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:112175871C>T	ENST00000457016.1	+	16	4960	c.4580C>T	c.(4579-4581)cCa>cTa	p.P1527L	APC_ENST00000257430.4_Missense_Mutation_p.P1527L|APC_ENST00000508376.2_Missense_Mutation_p.P1527L|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1527	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		ATAATGCCTCCAGTTCAGGAA	0.388000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			28	53					0	0	0.134883	0	0
MYO7B	4648	broad.mit.edu	37	2	128394193	128394193	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:128394193C>A	ENST00000389524.4	+	45	6175	c.6122C>A	c.(6121-6123)cCc>cAc	p.P2041H	MYO7B_ENST00000428314.1_Missense_Mutation_p.P2040H|MYO7B_ENST00000409816.2_Missense_Mutation_p.P2040H|MYO7B_ENST00000409090.1_Missense_Mutation_p.P893H			Q6PIF6	MYO7B_HUMAN	myosin VIIB	2040	FERM 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CTCATCCACCCCAAGACCAAG	0.647000													4	8					8.12818e-05	9.58543e-05	0.029380	1	0
EDIL3	10085	broad.mit.edu	37	5	83433157	83433157	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:83433157T>G	ENST00000296591.5	-	5	789	c.371A>C	c.(370-372)gAa>gCa	p.E124A	EDIL3_ENST00000380138.3_Missense_Mutation_p.E114A	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	124	EGF-like 3.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AGGCTCAACTTCGCATTCATT	0.333000													20	45					0	0	0.069288	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033761	82033761	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:82033761G>C	ENST00000328945.5	-	3	264	c.137C>G	c.(136-138)aCc>aGc	p.T46S	SDR42E1_ENST00000534209.1_5'UTR	NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	46					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						TTCTGGAATGGTTTGAGCAGG	0.458000													31	182					0	0	0.080422	0	0
SNRNP40	9410	broad.mit.edu	37	1	31740734	31740734	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:31740734C>A	ENST00000263694.4	-	8	922	c.904G>T	c.(904-906)Gct>Tct	p.A302S	SNRNP40_ENST00000373720.3_Missense_Mutation_p.A72S|SNRNP40_ENST00000489853.1_5'UTR|SNRNP40_ENST00000446633.2_Missense_Mutation_p.A302S	NM_004814.2	NP_004805.2	Q96DI7	SNR40_HUMAN	small nuclear ribonucleoprotein 40kDa (U5)	302						catalytic step 2 spliceosome|cytoplasm|nucleoplasm|small nucleolar ribonucleoprotein complex|U5 snRNP	protein binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|upper_aerodigestive_tract(1)	7						GCTGAGCCAGCTGCTATTTTG	0.473000													13	47					6.31663e-08	8.49873e-08	0.132662	1	0
CRHBP	1393	broad.mit.edu	37	5	76251567	76251567	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:76251567T>G	ENST00000274368.4	+	4	845	c.423T>G	c.(421-423)tgT>tgG	p.C141W	CRHBP_ENST00000506501.1_Missense_Mutation_p.C141W	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	141					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		TAGATTTCTGTGAGAGTGGTC	0.463000													20	36					0	0	0.055883	0	0
GOT2	2806	broad.mit.edu	37	16	58743428	58743428	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:58743428G>A	ENST00000245206.5	-	9	1191	c.1063C>T	c.(1063-1065)Cgg>Tgg	p.R355W	GOT2_ENST00000434819.2_Missense_Mutation_p.R312W	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	355					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding	p.R355W(2)|p.R355G(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AGTTGAGTCCGCATGCCAATG	0.507000													4	256					0	0	0.009096	0	0
SEMA5A	9037	broad.mit.edu	37	5	9154783	9154783	+	Missense_Mutation	SNP	C	C	T	rs138343991	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:9154783C>T	ENST00000382496.5	-	12	1963	c.1298G>A	c.(1297-1299)cGg>cAg	p.R433Q		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	433	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CAGGGGTACCCGCACTTTCTT	0.512000													14	75					0	0	0.033300	0	0
PRDM1	639	broad.mit.edu	37	6	106554875	106554875	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:106554875C>T	ENST00000369096.4	+	7	2226	c.1992C>T	c.(1990-1992)tgC>tgT	p.C664C	PRDM1_ENST00000369089.3_Silent_p.C530C|PRDM1_ENST00000369091.2_Silent_p.C628C	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	664					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GCAAGGTGTGCCCTGCCAAGT	0.547000			"""D, N, Mis, F, S"""		DLBCL								4	122					0	0	0.014758	0	0
NRAP	4892	broad.mit.edu	37	10	115349505	115349505	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:115349505G>C	ENST00000369358.4	-	41	5276	c.5032C>G	c.(5032-5034)Cct>Gct	p.P1678A	NRAP_ENST00000359988.3_Missense_Mutation_p.P1670A|NRAP_ENST00000369360.3_Missense_Mutation_p.P1643A|NRAP_ENST00000360478.3_Missense_Mutation_p.P1635A			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1670						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TAGGAGCCAGGAGGGGTCCAG	0.557000													13	32					0	0	0.146539	0	0
PLCL2	23228	broad.mit.edu	37	3	17056392	17056392	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:17056392A>T	ENST00000418129.2	+	3	3094	c.2629A>T	c.(2629-2631)Act>Tct	p.T877S	PLCL2_ENST00000432376.1_Missense_Mutation_p.T877S|PLCL2_ENST00000396755.2_Missense_Mutation_p.T877S	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1003					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GATCGTAACAACTTATGACAT	0.483000													20	100					0	0	0.043863	0	0
FAM135B	51059	broad.mit.edu	37	8	139209862	139209862	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:139209862C>G	ENST00000395297.1	-	8	890	c.720G>C	c.(718-720)tgG>tgC	p.W240C		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	240										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGTCTCGGTGCCACTTGTGTG	0.577000										HNSCC(54;0.14)			16	34					0	0	0.146539	0	0
MTRR	4552	broad.mit.edu	37	5	7878268	7878268	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:7878268G>A	ENST00000264668.2	+	5	724	c.694G>A	c.(694-696)Gag>Aag	p.E232K	MTRR_ENST00000440940.2_Missense_Mutation_p.E205K|MTRR_ENST00000341013.6_3'UTR	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	232	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	AAAGGATTCTGAGGTTTTGAA	0.458000													17	75					0	0	0.033300	0	0
MUC17	140453	broad.mit.edu	37	7	100677005	100677005	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:100677005A>C	ENST00000306151.4	+	3	2372	c.2308A>C	c.(2308-2310)Act>Cct	p.T770P		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	770	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTTTCAACAACTCCTCTTGA	0.473000													22	232					0	0	0.069288	0	0
PRR5	55615	broad.mit.edu	37	22	45132724	45132724	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:45132724A>T	ENST00000403581.1	+	10	1442	c.833A>T	c.(832-834)tAc>tTc	p.Y278F	ARHGAP8_ENST00000517296.3_Intron|ARHGAP8_ENST00000389773.5_Intron|PRR5_ENST00000477331.1_3'UTR|PRR5_ENST00000336985.6_Missense_Mutation_p.Y255F|PRR5-ARHGAP8_ENST00000352766.7_Intron|PRR5-ARHGAP8_ENST00000361473.5_Intron	NM_001198721.1	NP_001185650.1			proline rich 5 (renal)											central_nervous_system(1)|endometrium(2)|lung(6)|prostate(1)|skin(1)	11		all_neural(38;0.00409)|Ovarian(80;0.024)|Glioma(61;0.0647)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)		TCCAAGAGCTACAACACGCCT	0.682000													5	10					0	0	0.014758	0	0
CACNA1C	775	broad.mit.edu	37	12	2775889	2775889	+	Silent	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:2775889C>A	ENST00000399655.1	+	37	4829	c.4564C>A	c.(4564-4566)Cgg>Agg	p.R1522R	CACNA1C_ENST00000399629.1_Silent_p.R1539R|CACNA1C_ENST00000399606.1_Silent_p.R1542R|CACNA1C_ENST00000327702.7_Silent_p.R1522R|CACNA1C_ENST00000335762.5_Silent_p.R1547R|CACNA1C_ENST00000399649.1_Silent_p.R1509R|CACNA1C_ENST00000399638.1_Silent_p.R1550R|CACNA1C_ENST00000399603.1_Silent_p.R1522R|CACNA1C_ENST00000399617.1_Silent_p.R1522R|CACNA1C_ENST00000399591.1_Silent_p.R1511R|CACNA1C_ENST00000399597.1_Silent_p.R1522R|CACNA1C_ENST00000406454.3_Silent_p.R1522R|CACNA1C_ENST00000399595.1_Silent_p.R1511R|CACNA1C_ENST00000402845.3_Silent_p.R1522R|CACNA1C_ENST00000399644.1_Silent_p.R1522R|CACNA1C_ENST00000399637.1_Silent_p.R1522R|CACNA1C_ENST00000399621.1_Silent_p.R1522R|CACNA1C_ENST00000347598.4_Silent_p.R1570R|CACNA1C_ENST00000344100.3_Silent_p.R1544R|CACNA1C_ENST00000399634.1_Silent_p.R1522R|CACNA1C_ENST00000399601.1_Silent_p.R1522R|CACNA1C_ENST00000399641.1_Silent_p.R1522R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1570	Dihydropyridine binding (By similarity).|Phenylalkylamine binding (By similarity).				axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GACCCTCCTCCGGCGGATTCA	0.587000													5	11					1.23904e-05	1.5031e-05	0.014758	1	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768824	31768824	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:31768824G>T	ENST00000355459.2	+	1	433	c.420G>T	c.(418-420)ctG>ctT	p.L140L		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	140						intermediate filament				endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCCCTTCCCTGGGCTATGGCG	0.567000													11	28					3.07112e-06	3.85191e-06	0.080935	1	0
WBSCR17	64409	broad.mit.edu	37	7	71130408	71130408	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:71130408G>A	ENST00000333538.5	+	7	1727	c.1093G>A	c.(1093-1095)Ggg>Agg	p.G365R	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	365	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ATGGCTCTGTGGGGGCAGCAT	0.512000													24	84					0	0	0.108266	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125521610	125521610	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:125521610A>G	ENST00000431078.1	+	16	2780	c.2416A>G	c.(2416-2418)Acc>Gcc	p.T806A		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	806	Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		CCACTTTCCTACCTTCCATGC	0.408000													30	116					0	0	0.134883	0	0
NOD2	64127	broad.mit.edu	37	16	50745449	50745449	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:50745449C>T	ENST00000300589.2	+	4	1732	c.1627C>T	c.(1627-1629)Cgc>Tgc	p.R543C		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	543	NACHT.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding	p.R543C(1)		cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				TCTTCGGGGCCGCCTCCCCAC	0.617000													4	34					0	0	0.009096	0	0
NLGN1	22871	broad.mit.edu	37	3	173997312	173997312	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:173997312C>A	ENST00000457714.1	+	6	1950	c.1521C>A	c.(1519-1521)gaC>gaA	p.D507E	NLGN1_ENST00000401917.3_Missense_Mutation_p.D547E|NLGN1_ENST00000361589.4_Missense_Mutation_p.D507E|NLGN1_ENST00000545397.1_Missense_Mutation_p.D507E	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	524					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity	p.D507D(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCCACGGAGACGAGGTTCCCT	0.453000													9	43					0.0477658	0.0504952	0.047766	1	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139104	90139104	+	RNA	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:90139104C>A	ENST00000492446.1	+	0	27																											CAGGACACAGCATGGACATGA	0.542000													31	153					2.85442e-18	4.59189e-18	0.045705	1	0
LRP1B	53353	broad.mit.edu	37	2	141625751	141625751	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:141625751G>T	ENST00000389484.3	-	26	5222	c.4251C>A	c.(4249-4251)atC>atA	p.I1417I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1417					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTCTTTATAGATGGTTTTTC	0.393000										TSP Lung(27;0.18)			20	51					3.8784e-16	6.10642e-16	0.062417	1	0
PCDHGA2	56113	broad.mit.edu	37	5	140719887	140719887	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:140719887C>G	ENST00000394576.2	+	1	1349	c.1349C>G	c.(1348-1350)cCc>cGc	p.P450R	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAACGCACCCGCCTTCTCC	0.552000													33	69					0	0	0.059317	0	0
CPN1	1369	broad.mit.edu	37	10	101816798	101816798	+	Missense_Mutation	SNP	C	C	A	rs140666731	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:101816798C>A	ENST00000370418.3	-	6	1234	c.983G>T	c.(982-984)cGg>cTg	p.R328L		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	328	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding	p.R328L(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TAGGGCTTCCCGATTACCCAG	0.458000													34	215					3.90053e-15	6.0448e-15	0.050027	1	0
IGHV3-35	28432	broad.mit.edu	37	14	106845521	106845521	+	RNA	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:106845521A>G	ENST00000390617.2	-	0	167																											AGTTCATGTCACTGTTACTGA	0.567000													47	638					0	0	0.139131	0	0
SPHKAP	80309	broad.mit.edu	37	2	228883645	228883645	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:228883645G>A	ENST00000392056.3	-	7	1971	c.1925C>T	c.(1924-1926)tCc>tTc	p.S642F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S642F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	642						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CCTGTTCATGGAGTCCAGAAA	0.478000													16	40					0	0	0.146539	0	0
SPATA31E1	286234	broad.mit.edu	37	9	90502663	90502663	+	Silent	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:90502663A>G	ENST00000325643.5	+	4	3327	c.3261A>G	c.(3259-3261)ccA>ccG	p.P1087P		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CTCAGGATCCAGAGCAGCTGC	0.612000													4	69					0	0	0.009096	0	0
ABCC12	94160	broad.mit.edu	37	16	48174704	48174704	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:48174704C>T	ENST00000311303.3	-	4	896	c.551G>A	c.(550-552)tGg>tAg	p.W184*	ABCC12_ENST00000448542.1_Nonsense_Mutation_p.W184*|ABCC12_ENST00000416054.1_Nonsense_Mutation_p.W184*	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	184	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.W184L(1)		NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				GTTGATGGCCCAGGCAAGGGC	0.522000													28	177					0	0	0.116897	0	0
TBC1D31	93594	broad.mit.edu	37	8	124140704	124140704	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:124140704C>G	ENST00000287380.1	+	14	2158	c.2068C>G	c.(2068-2070)Cag>Gag	p.Q690E	TBC1D31_ENST00000522420.1_Missense_Mutation_p.Q585E|TBC1D31_ENST00000378080.2_Missense_Mutation_p.Q585E|TBC1D31_ENST00000518805.1_Intron|TBC1D31_ENST00000327098.5_Missense_Mutation_p.Q690E|TBC1D31_ENST00000309336.3_Missense_Mutation_p.Q690E|TBC1D31_ENST00000521676.1_Missense_Mutation_p.Q567E	NM_145647.3	NP_663622.2			TBC1 domain family, member 31																		CTATCAAACACAGGAACGAGA	0.313000													12	57					0	0	0.105934	0	0
SYT9	143425	broad.mit.edu	37	11	7334892	7334892	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:7334892C>A	ENST00000318881.6	+	3	1001	c.764C>A	c.(763-765)aCt>aAt	p.T255N	SYT9_ENST00000396716.2_Missense_Mutation_p.T223N	NM_175733.3	NP_783860.1	Q86SS6	SYT9_HUMAN	synaptotagmin IX	255	C2 1.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(2)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	38				Epithelial(150;1.34e-07)|LUSC - Lung squamous cell carcinoma(625;0.0949)		TTTTCTGGGACTTCAGATCCT	0.408000													10	83					0.00829132	0.0090229	0.069234	1	0
ZNF157	7712	broad.mit.edu	37	X	47272470	47272470	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:47272470G>T	ENST00000377073.3	+	4	1084	c.998G>T	c.(997-999)gGt>gTt	p.G333V		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	333					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						TATGAGTGTGGTGAATGTGGG	0.403000													14	28					3.27435e-08	4.4664e-08	0.119110	1	0
GPR84	53831	broad.mit.edu	37	12	54756620	54756620	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:54756620T>C	ENST00000551809.1	-	1	1651	c.1016A>G	c.(1015-1017)aAc>aGc	p.N339S	GPR84_ENST00000267015.3_Missense_Mutation_p.N339S|RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA			Q9NQS5	GPR84_HUMAN	G protein-coupled receptor 84	339						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|kidney(2)|large_intestine(6)|lung(5)|skin(1)|urinary_tract(1)	18						ATCCAGAATGTTGAGCAGCAA	0.542000													29	83					0	0	0.050027	0	0
CDH18	1016	broad.mit.edu	37	5	19612586	19612586	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:19612586G>C	ENST00000507958.1	-	8	1758	c.768C>G	c.(766-768)atC>atG	p.I256M	CDH18_ENST00000502796.1_Missense_Mutation_p.I256M|CDH18_ENST00000382275.1_Missense_Mutation_p.I256M|CDH18_ENST00000506372.1_Missense_Mutation_p.I256M|CDH18_ENST00000274170.4_Missense_Mutation_p.I256M|CDH18_ENST00000511273.1_Missense_Mutation_p.I256M			Q13634	CAD18_HUMAN	cadherin 18, type 2	256	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CGGTTAAGGTGATGTTGACTG	0.403000													6	50					0	0	0.021553	0	0
FPR2	2358	broad.mit.edu	37	19	52272462	52272462	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:52272462G>T	ENST00000598776.1	+	2	1323	c.551G>T	c.(550-552)gGt>gTt	p.G184V	FPR2_ENST00000340023.6_Missense_Mutation_p.G184V|FPR2_ENST00000598953.1_Missense_Mutation_p.G184V	NM_001462.3	NP_001453.1	P25090	FPR2_HUMAN	formyl peptide receptor 2	184					cell adhesion|cellular component movement|chemotaxis|inflammatory response	integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33						GCATCCTGGGGTGGCACCCCT	0.473000													27	67					5.61819e-17	8.94077e-17	0.108266	1	0
ZP4	57829	broad.mit.edu	37	1	238053889	238053889	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:238053889G>A	ENST00000366570.4	-	1	205	c.47C>T	c.(46-48)gCt>gTt	p.A16V	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	16					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCCACTCACAGCAAGAGATAA	0.552000													3	51					0	0	0.115264	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6463	6463	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrM:6463C>T	ENST00000361624.2	+	1	560	c.560C>T	c.(559-561)tCc>tTc	p.187_187insF						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						CTTCGTCTGATCCGTCCTAAT	0.468000													26	305					0	0	0.134883	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044417	90044417	+	RNA	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:90044417G>T	ENST00000462693.1	+	0	368																											GTTTATTACTGCACGCAAGCT	0.532000													54	191					4.45325e-31	7.48956e-31	0.139131	1	0
TRIQK	286144	broad.mit.edu	37	8	93898855	93898855	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:93898855C>A	ENST00000521988.1	-	5	574	c.256G>T	c.(256-258)Gat>Tat	p.D86Y	TRIQK_ENST00000519069.1_3'UTR|CTD-3239E11.2_ENST00000523197.1_RNA|TRIQK_ENST00000537541.1_Missense_Mutation_p.D86Y|TRIQK_ENST00000520686.1_Missense_Mutation_p.D86Y|TRIQK_ENST00000518748.1_Missense_Mutation_p.D86Y|TRIQK_ENST00000521617.1_Missense_Mutation_p.D86Y|CTD-3239E11.2_ENST00000521203.1_RNA|TRIQK_ENST00000520430.1_Missense_Mutation_p.D86Y|TRIQK_ENST00000524037.1_3'UTR|TRIQK_ENST00000519969.1_Missense_Mutation_p.D86Y|TRIQK_ENST00000523580.1_3'UTR|TRIQK_ENST00000517540.1_5'UTR|TRIQK_ENST00000524107.1_Missense_Mutation_p.D86Y|TRIQK_ENST00000517858.1_3'UTR|TRIQK_ENST00000378861.5_Missense_Mutation_p.D86Y	NM_001171797.1	NP_001165268.1	Q629K1	TRIQK_HUMAN	triple QxxK/R motif containing	86						endoplasmic reticulum membrane|integral to membrane				endometrium(3)	3						CTTAGCTAATCTTCATCTTGG	0.383000													6	10					0.00307968	0.00338879	0.038147	1	0
TRBV6-8	28599	broad.mit.edu	37	7	142124428	142124428	+	RNA	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:142124428C>A	ENST00000390376.2	-	0	49																											ATTCACTGGACCTGCAGAGAA	0.552000													51	117					8.00217e-19	1.29434e-18	0.139131	1	0
TMEM132A	54972	broad.mit.edu	37	11	60699470	60699470	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:60699470G>A	ENST00000005286.4	+	7	1383	c.1230G>A	c.(1228-1230)gtG>gtA	p.V410V	TMEM132A_ENST00000453848.2_Silent_p.V409V	NM_017870.3|NM_178031.2	NP_060340.2|NP_821174.1	Q24JP5	T132A_HUMAN	transmembrane protein 132A	409						endoplasmic reticulum membrane|Golgi membrane|integral to membrane				breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|prostate(1)|skin(3)	32						AGGAGCTGGTGAATACAGCAC	0.667000													5	18					0	0	0.021553	0	0
FMN2	56776	broad.mit.edu	37	1	240635683	240635683	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:240635683C>A	ENST00000319653.9	+	17	5302	c.5072C>A	c.(5071-5073)gCc>gAc	p.A1691D	FMN2_ENST00000545751.1_Missense_Mutation_p.A287D|FMN2_ENST00000543681.1_Missense_Mutation_p.A11D|FMN2_ENST00000496950.1_3'UTR|AL646016.1_ENST00000596886.1_Intron	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1691	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTAAAAGAAGCCGAAGAGGTG	0.333000													24	43					3.28513e-13	4.98665e-13	0.091800	1	0
ANK3	288	broad.mit.edu	37	10	61832647	61832647	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:61832647C>T	ENST00000280772.1	-	37	8183	c.7992G>A	c.(7990-7992)gaG>gaA	p.E2664E	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2664					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGGGTGCCTTCTCCTCGGCCT	0.537000													4	50					0	0	0.021553	0	0
ABCC11	85320	broad.mit.edu	37	16	48204061	48204061	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:48204061C>T	ENST00000394747.1	-	27	4195	c.3846G>A	c.(3844-3846)gaG>gaA	p.E1282E	ABCC11_ENST00000394748.1_Silent_p.E1282E|ABCC11_ENST00000353782.5_Intron|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000356608.2_Silent_p.E1282E	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1282	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GCAGCTGCCTCTCCCCCACAG	0.542000													46	198					0	0	0.139131	0	0
WDPCP	51057	broad.mit.edu	37	2	63631702	63631702	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:63631702C>T	ENST00000409120.1	-	4	3890	c.340G>A	c.(340-342)Gta>Ata	p.V114I	WDPCP_ENST00000398544.3_Missense_Mutation_p.V147I|WDPCP_ENST00000409199.1_Missense_Mutation_p.V114I|WDPCP_ENST00000409562.3_Missense_Mutation_p.V306I|WDPCP_ENST00000409835.1_5'UTR|WDPCP_ENST00000272321.7_Missense_Mutation_p.V306I			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	306					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						TCTACACTTACGGAGTGCTCC	0.468000													21	147					0	0	0.062417	0	0
ZAN	7455	broad.mit.edu	37	7	100350349	100350349	+	RNA	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:100350349C>A	ENST00000542585.1	+	0	2769				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTCACCATCCCCACGGAAAAA	0.498000													8	13					0.000673444	0.00076669	0.069234	1	0
TBX22	50945	broad.mit.edu	37	X	79282220	79282220	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:79282220G>T	ENST00000442340.1	+	6	781	c.291G>T	c.(289-291)atG>atT	p.M97I	TBX22_ENST00000373296.3_Missense_Mutation_p.M217I|TBX22_ENST00000373294.5_Missense_Mutation_p.M217I|TBX22_ENST00000373291.1_Missense_Mutation_p.M97I	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	217					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TGCAATCCATGCATAAGTACA	0.483000													15	79					3.27435e-08	4.4664e-08	0.119110	1	0
LAMA2	3908	broad.mit.edu	37	6	129634156	129634156	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:129634156T>A	ENST00000421865.2	+	23	3374	c.3325T>A	c.(3325-3327)Ttc>Atc	p.F1109I		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1109	Laminin EGF-like 13.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGTGACTGCTTCCTCCCTGG	0.483000													8	78					0	0	0.038147	0	0
GEM	2669	broad.mit.edu	37	8	95262780	95262780	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:95262780A>G	ENST00000297596.2	-	5	913	c.649T>C	c.(649-651)Ttc>Ctc	p.F217L	GEM_ENST00000396194.2_Missense_Mutation_p.F217L	NM_005261.3	NP_005252.1	P55040	GEM_HUMAN	GTP binding protein overexpressed in skeletal muscle	217					cell surface receptor linked signaling pathway|immune response|small GTPase mediated signal transduction	internal side of plasma membrane	calmodulin binding|GDP binding|GTP binding|GTPase activity|magnesium ion binding			endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(36;4.65e-06)	Myeloproliferative disorder(644;0.204)	BRCA - Breast invasive adenocarcinoma(8;0.00691)			GTCTCGATGAACTTGCAGTCA	0.552000													19	54					0	0	0.049695	0	0
ALPK2	115701	broad.mit.edu	37	18	56247641	56247641	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:56247641T>A	ENST00000361673.3	-	4	580	c.367A>T	c.(367-369)Agg>Tgg	p.R123W		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	123							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTCCAACCCCTGTCCCTGTCA	0.443000													5	96					0	0	0.021553	0	0
DCHS2	54798	broad.mit.edu	37	4	155180879	155180879	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:155180879G>T	ENST00000357232.3	-	20	5241	c.5242C>A	c.(5242-5244)Ctt>Att	p.L1748I		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1748	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TCAAAATCAAGAAACTTGGGT	0.318000													13	56					9.31168e-06	1.14368e-05	0.105934	1	0
RYR2	6262	broad.mit.edu	37	1	237947956	237947956	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:237947956G>T	ENST00000366574.2	+	90	13261	c.12944G>T	c.(12943-12945)gGg>gTg	p.G4315V	RYR2_ENST00000360064.6_Missense_Mutation_p.G4321V|RYR2_ENST00000542537.1_Missense_Mutation_p.G4299V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4315					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTGCTGCTTGGGGGAAGCCTC	0.507000													35	58					6.53348e-20	1.07439e-19	0.064281	1	0
ZNF485	220992	broad.mit.edu	37	10	44112694	44112694	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:44112694G>C	ENST00000361807.3	+	5	1397	c.1203G>C	c.(1201-1203)caG>caC	p.Q401H	ZNF485_ENST00000374435.3_Missense_Mutation_p.Q401H|ZNF485_ENST00000374437.2_Missense_Mutation_p.Q310H	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	401					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						TTGAACATCAGAGACTCCATA	0.408000													17	26					0	0	0.043863	0	0
DLG2	1740	broad.mit.edu	37	11	83183817	83183817	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:83183817C>T	ENST00000398309.2	-	18	2452	c.1982G>A	c.(1981-1983)gGa>gAa	p.G661E	DLG2_ENST00000532653.1_Missense_Mutation_p.G643E|DLG2_ENST00000524982.1_Missense_Mutation_p.G657E|DLG2_ENST00000531015.1_Missense_Mutation_p.G628E|DLG2_ENST00000280241.8_Missense_Mutation_p.G700E|DLG2_ENST00000418306.2_Missense_Mutation_p.G540E|DLG2_ENST00000376104.2_Missense_Mutation_p.G766E|DLG2_ENST00000426717.2_Missense_Mutation_p.G125E|DLG2_ENST00000543673.1_Missense_Mutation_p.G766E|DLG2_ENST00000376106.3_Missense_Mutation_p.G125E|DLG2_ENST00000537455.1_Missense_Mutation_p.G411E|DLG2_ENST00000404783.3_Missense_Mutation_p.G139E|DLG2_ENST00000330014.6_Missense_Mutation_p.G582E	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	661						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GTCTTCTTGTCCTCCTGAGAA	0.443000													18	21					0	0	0.055883	0	0
RGL3	57139	broad.mit.edu	37	19	11507974	11507974	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:11507974G>A	ENST00000380456.3	-	18	2023	c.1960C>T	c.(1960-1962)Ccc>Tcc	p.P654S	RGL3_ENST00000568628.1_5'UTR|RGL3_ENST00000393423.3_Missense_Mutation_p.P660S	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	654	Interaction with HRAS, MRAS and RIT1 (By similarity).|Ras-associating.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						CAGGGCTGGGGCACATTGTGC	0.662000													21	31					0	0	0.091800	0	0
SLC9B1	150159	broad.mit.edu	37	4	103822371	103822371	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:103822371C>A	ENST00000296422.7	-	12	1592	c.1451G>T	c.(1450-1452)gGa>gTa	p.G484V	SLC9B1_ENST00000512651.2_5'UTR|SLC9B1_ENST00000394789.3_Intron	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	484						integral to membrane	solute:hydrogen antiporter activity										AAGTAGAGCTCCATTTGGAGC	0.423000													6	209					0.0381472	0.0404716	0.038147	1	0
SLC2A12	154091	broad.mit.edu	37	6	134350827	134350827	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:134350827T>A	ENST00000275230.5	-	2	291	c.136A>T	c.(136-138)Act>Tct	p.T46S		NM_145176.2	NP_660159.1	Q8TD20	GTR12_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 12	46						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity			NS(1)|breast(1)|large_intestine(6)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	17	Breast(56;0.214)|Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.0101)|GBM - Glioblastoma multiforme(68;0.0123)		ACAGCAGCAGTGACAGATGAC	0.483000													10	80					0	0	0.058154	0	0
DNASE2B	58511	broad.mit.edu	37	1	84880404	84880404	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:84880404G>A	ENST00000370665.3	+	6	972	c.939G>A	c.(937-939)aaG>aaA	p.K313K	DNASE2B_ENST00000370662.3_Silent_p.K105K	NM_021233.2	NP_067056.2	Q8WZ79	DNS2B_HUMAN	deoxyribonuclease II beta	313					DNA metabolic process	lysosome	deoxyribonuclease II activity			endometrium(1)|lung(4)|skin(1)	6				all cancers(265;0.00303)|Epithelial(280;0.0112)|OV - Ovarian serous cystadenocarcinoma(397;0.0808)		TTTCCCAAAAGGGCACCAAAA	0.398000													4	30					0	0	0.009096	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64142982	64142982	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:64142982G>T	ENST00000295902.6	-	5	1041	c.456C>A	c.(454-456)ggC>ggA	p.G152G	PRICKLE2_ENST00000564377.1_Silent_p.G208G	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	152	LIM zinc-binding 1.					cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		GCCAGCAAACGCCGTGGCCAG	0.552000													8	26					0.0381472	0.0404716	0.038147	1	0
RP2	6102	broad.mit.edu	37	X	46713150	46713150	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:46713150C>A	ENST00000218340.3	+	2	503	c.342C>A	c.(340-342)tgC>tgA	p.C114*		NM_006915.2	NP_008846.2	O75695	XRP2_HUMAN	retinitis pigmentosa 2 (X-linked recessive)	114	C-CAP/cofactor C-like.				cell morphogenesis|CTP biosynthetic process|GTP biosynthetic process|protein folding|UTP biosynthetic process|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding			NS(1)|large_intestine(4)|lung(5)|stomach(1)	11						CATTAGCCTGCCAACAATTTC	0.418000													8	82					1.58986e-06	2.01111e-06	0.069234	1	0
MCOLN1	57192	broad.mit.edu	37	19	7593514	7593514	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:7593514G>T	ENST00000264079.6	+	8	1034	c.909G>T	c.(907-909)gtG>gtT	p.V303V		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	303					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGTTTGACGTGGTGGTCATCC	0.622000													15	19					4.7546e-09	6.79885e-09	0.146539	1	0
WDTC1	23038	broad.mit.edu	37	1	27614294	27614294	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:27614294G>T	ENST00000319394.3	+	6	956	c.421G>T	c.(421-423)Gcc>Tcc	p.A141S	WDTC1_ENST00000361771.3_Missense_Mutation_p.A141S	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	141							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		GAAGCGCATCGCCACAGCGCC	0.582000													5	18					0.00198382	0.00220756	0.029380	1	0
MEOX1	4222	broad.mit.edu	37	17	41738663	41738663	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:41738663G>T	ENST00000549132.1	-	1	268	c.152C>A	c.(151-153)tCt>tAt	p.S51Y	MEOX1_ENST00000329168.3_Silent_p.I80I|MEOX1_ENST00000318579.4_Silent_p.I80I|MEOX1_ENST00000393661.2_5'UTR			P50221	MEOX1_HUMAN	mesenchyme homeobox 1	27						nucleus	sequence-specific DNA binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		GCTCAGTGAAGATGTGCTCCT	0.657000													7	33					2.7689e-08	3.84786e-08	0.029380	1	0
MAMLD1	10046	broad.mit.edu	37	X	149639223	149639223	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:149639223C>A	ENST00000370401.2	+	4	1688	c.1378C>A	c.(1378-1380)Cca>Aca	p.P460T	MAMLD1_ENST00000426613.2_Missense_Mutation_p.P435T|MAMLD1_ENST00000262858.5_Missense_Mutation_p.P460T|MAMLD1_ENST00000432680.2_Missense_Mutation_p.P435T			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	460					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					ACCCTATCGCCCAGAGAAGCT	0.572000													37	82					1.36161e-19	2.22673e-19	0.069456	1	0
PIK3R6	146850	broad.mit.edu	37	17	8730560	8730560	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:8730560C>A	ENST00000311434.9	-	13	1683	c.1444G>T	c.(1444-1446)Ggc>Tgc	p.G482C	PIK3R6_ENST00000434064.2_5'UTR	NM_001010855.2	NP_001010855.1	Q5UE93	PI3R6_HUMAN	phosphoinositide-3-kinase, regulatory subunit 6	482					platelet activation	cytosol											TCTACGCGGCCCAGGAACGTA	0.657000													8	15					0.000274275	0.000318374	0.047766	1	0
CCDC150	284992	broad.mit.edu	37	2	197521518	197521518	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:197521518C>T	ENST00000389175.4	+	3	473	c.338C>T	c.(337-339)tCc>tTc	p.S113F	CCDC150_ENST00000423093.2_Intron|CCDC150_ENST00000472405.2_Missense_Mutation_p.S10F|CCDC150_ENST00000272831.7_Intron	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	113										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						CTCATGCAGTCCTTGAAGATG	0.383000													23	70					0	0	0.099896	0	0
OR7A17	26333	broad.mit.edu	37	19	14991763	14991763	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:14991763G>T	ENST00000327462.2	-	1	501	c.405C>A	c.(403-405)atC>atA	p.I135I		NM_030901.1	NP_112163.1	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A, member 17	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12	Ovarian(108;0.203)					GAGGGTTCATGATGACTGTGT	0.488000													36	64					2.40579e-17	3.84927e-17	0.086207	1	0
LRP1	4035	broad.mit.edu	37	12	57602924	57602924	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:57602924C>T	ENST00000243077.3	+	79	12670	c.12204C>T	c.(12202-12204)gtC>gtT	p.V4068V		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	4068					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGCTTTCAGTCATCGGCAGCA	0.612000													8	31					0	0	0.058154	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732582	37732582	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:37732582G>A	ENST00000330843.4	-	3	1085	c.1073C>T	c.(1072-1074)aCa>aTa	p.T358I	RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.T358I|RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.T210I|RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.T210I	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	358					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CAGGTTCTCTGTAGAAGAGAA	0.562000													30	65					0	0	0.125774	0	0
ZNF746	155061	broad.mit.edu	37	7	149191294	149191294	+	Splice_Site	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:149191294C>T	ENST00000461958.2	-	2	521		c.e2+1		ZNF746_ENST00000340622.3_Splice_Site|ZNF746_ENST00000458143.2_Splice_Site			Q6NUN9	ZN746_HUMAN	zinc finger protein 746						negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CCCAGGGCTACCTTAGGGGAC	0.657000													52	131					0	0	0.139131	0	0
SYNE1	23345	broad.mit.edu	37	6	152770719	152770719	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:152770719C>A	ENST00000367255.5	-	28	4054	c.3453G>T	c.(3451-3453)aaG>aaT	p.K1151N	SYNE1_ENST00000367253.4_Missense_Mutation_p.K1151N|SYNE1_ENST00000448038.1_Missense_Mutation_p.K1158N|SYNE1_ENST00000413186.2_Missense_Mutation_p.K1151N|SYNE1_ENST00000423061.1_Missense_Mutation_p.K1158N|SYNE1_ENST00000265368.4_Missense_Mutation_p.K1151N|SYNE1_ENST00000367248.3_Missense_Mutation_p.K1141N|SYNE1_ENST00000341594.5_Missense_Mutation_p.K1217N	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1151					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TGGCCTCACCCTTGATCCCCT	0.403000										HNSCC(10;0.0054)			6	82					0.00198382	0.00220756	0.029380	1	0
ASB17	127247	broad.mit.edu	37	1	76397586	76397586	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:76397586G>A	ENST00000284142.6	-	1	530	c.391C>T	c.(391-393)Ctg>Ttg	p.L131L		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	131					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						CTCCATATCAGTGCCAGGTTA	0.343000													9	22					0	0	0.047766	0	0
LRRTM3	347731	broad.mit.edu	37	10	68686880	68686880	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:68686880G>A	ENST00000361320.4	+	2	784	c.206G>A	c.(205-207)cGc>cAc	p.R69H	CTNNA3_ENST00000494580.1_Intron|CTNNA3_ENST00000373744.4_Intron|CTNNA3_ENST00000433211.1_Intron	NM_178011.3	NP_821079.3	Q86VH5	LRRT3_HUMAN	leucine rich repeat transmembrane neuronal 3	69						integral to membrane				breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	41						TTGTCCCTTCGCTATAACAGC	0.398000													39	70					0	0	0.074837	0	0
KDM2B	84678	broad.mit.edu	37	12	121878958	121878958	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:121878958G>A	ENST00000377069.4	-	19	3562	c.3156C>T	c.(3154-3156)atC>atT	p.I1052I	KDM2B_ENST00000377071.4_Silent_p.I1121I|KDM2B_ENST00000536437.1_Intron|KDM2B_ENST00000542973.1_Silent_p.I489I	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	1121	Pro-rich.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						GTCGCCGGATGATGCCACTCA	0.622000													5	61					0	0	0.021553	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305029	61305029	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:61305029T>C	ENST00000341074.5	-	8	1212	c.1097A>G	c.(1096-1098)aAt>aGt	p.N366S	SERPINB4_ENST00000356424.6_Missense_Mutation_p.N314S	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						GAAAGGGTGATTACAACAGAA	0.438000													30	80					0	0	0.144211	0	0
BAGE2	85319	broad.mit.edu	37	21	11039232	11039232	+	RNA	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:11039232C>A	ENST00000470054.1	-	0	971									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TCTTTGGATACCACTGTTTTA	0.408000													13	250					9.31168e-06	1.14368e-05	0.105934	1	0
TMEM8B	51754	broad.mit.edu	37	9	35853738	35853738	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:35853738G>T	ENST00000377988.2	+	13	2608	c.1320G>T	c.(1318-1320)cgG>cgT	p.R440R	TMEM8B_ENST00000377991.4_Silent_p.R440R	NM_001042590.2	NP_001036055.1	A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	440					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						CTGGAGCCCGGGCCCGGGGCT	0.632000													10	18					3.86212e-05	4.62829e-05	0.069234	1	0
PLAT	5327	broad.mit.edu	37	8	42048920	42048920	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:42048920G>T	ENST00000220809.4	-	3	341	c.85C>A	c.(85-87)Cga>Aga	p.R29R	PLAT_ENST00000352041.3_Silent_p.R29R|PLAT_ENST00000524009.1_Silent_p.R29R|PLAT_ENST00000429710.2_Silent_p.R29R|PLAT_ENST00000429089.2_Silent_p.R29R|PLAT_ENST00000270189.6_Silent_p.R29R|PLAT_ENST00000519510.1_Silent_p.R29R	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	29					blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	CTTCTGAATCGGGCATGGATT	0.582000													24	68					1.16021e-09	1.69173e-09	0.125774	1	0
CDCA2	157313	broad.mit.edu	37	8	25346185	25346185	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:25346185G>A	ENST00000330560.3	+	13	2128	c.1651G>A	c.(1651-1653)Gca>Aca	p.A551T	CDCA2_ENST00000380665.3_Missense_Mutation_p.A536T|CDCA2_ENST00000521098.2_3'UTR	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	551	Lys-rich.				cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TACAAAGAGAGCACTTCCTAA	0.323000													9	46					0	0	0.080935	0	0
CRLF2	64109	broad.mit.edu	37	X	1315012	1315012	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:1315012C>A	ENST00000381567.3	-	6	648	c.649G>T	c.(649-651)Gcc>Tcc	p.A217S	CRLF2_ENST00000467626.1_5'UTR	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	217						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TCTGCACAGGCATCTGAAACA	0.473000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								4	34					0.0215528	0.0230311	0.021553	1	0
PRUNE	58497	broad.mit.edu	37	1	150998086	150998086	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:150998086C>G	ENST00000271620.3	+	5	772	c.616C>G	c.(616-618)Cca>Gca	p.P206A	PRUNE_ENST00000368937.1_Missense_Mutation_p.P24A|PRUNE_ENST00000368935.1_Intron|PRUNE_ENST00000271619.8_Missense_Mutation_p.P47A|PRUNE_ENST00000368934.1_Missense_Mutation_p.P24A|PRUNE_ENST00000467771.1_3'UTR|PRUNE_ENST00000368936.1_Missense_Mutation_p.P24A	NM_021222.1	NP_067045.1	Q86TP1	PRUNE_HUMAN	prune exopolyphosphatase	206						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGCCCTTTTCCCAGACCTACC	0.423000													30	177					0	0	0.054565	0	0
TECTA	7007	broad.mit.edu	37	11	121000540	121000540	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:121000540C>T	ENST00000392793.1	+	10	2832	c.2561C>T	c.(2560-2562)gCc>gTc	p.A854V	TECTA_ENST00000264037.2_Missense_Mutation_p.A854V			O75443	TECTA_HUMAN	tectorin alpha	854	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TTCTACAATGCCAACGCCAGT	0.537000													9	68					0	0	0.058154	0	0
FKBP6	8468	broad.mit.edu	37	7	72755322	72755322	+	Silent	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:72755322A>G	ENST00000252037.4	+	7	903	c.834A>G	c.(832-834)cgA>cgG	p.R278R	FKBP6_ENST00000413573.2_Silent_p.R248R|FKBP6_ENST00000431982.2_Silent_p.R273R	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	278					protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				TTCTAGTTCGAGCCCAGAAGG	0.458000													40	130					0	0	0.092188	0	0
IGHV3-23	28442	broad.mit.edu	37	14	106725382	106725382	+	RNA	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:106725382C>T	ENST00000390609.2	-	0	248																											TGGAGCCTGGCGGACCCAGCT	0.597000													5	651					0	0	0.014758	0	0
MARCH10	162333	broad.mit.edu	37	17	60813722	60813722	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:60813722C>T	ENST00000544856.2	-	7	1882	c.1504G>A	c.(1504-1506)Gga>Aga	p.G502R	RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.G503R|MARCH10_ENST00000583600.1_Missense_Mutation_p.G541R|RP11-156L14.1_ENST00000579201.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000311269.5_Missense_Mutation_p.G503R			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	503							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CCTGAGTTTCCCTCTGAGTCT	0.438000													22	64					0	0	0.069288	0	0
BRDT	676	broad.mit.edu	37	1	92447221	92447221	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:92447221G>A	ENST00000370389.2	+	12	2616	c.1692G>A	c.(1690-1692)ctG>ctA	p.L564L	BRDT_ENST00000402388.1_Silent_p.L637L|BRDT_ENST00000399546.2_Silent_p.L637L|BRDT_ENST00000362005.3_Silent_p.L637L|BRDT_ENST00000394530.3_Silent_p.L591L	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	637					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		TTTCCCGACTGAGTGAGagca	0.423000													12	61					0	0	0.132662	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29301284	29301284	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:29301284G>T	ENST00000378993.1	+	3	985	c.312G>T	c.(310-312)tgG>tgT	p.W104C	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.W104C	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	104	Ig-like C2-type 1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						ACTCCATTTGGTTCCGGCCAA	0.448000													27	72					1.12875e-08	1.59862e-08	0.116897	1	0
PRPS1	5631	broad.mit.edu	37	X	106884176	106884176	+	Silent	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:106884176T>A	ENST00000372435.4	+	3	473	c.351T>A	c.(349-351)tcT>tcA	p.S117S	PRPS1_ENST00000372419.3_Silent_p.S117S|PRPS1_ENST00000543248.1_Silent_p.S117S|PRPS1_ENST00000372418.1_Intron|PRPS1_ENST00000372428.4_Silent_p.S50S	NM_002764.3	NP_002755.1	P60891	PRPS1_HUMAN	phosphoribosyl pyrophosphate synthetase 1	117					5-phosphoribose 1-diphosphate biosynthetic process|hypoxanthine biosynthetic process|nervous system development|nucleoside metabolic process|purine nucleotide biosynthetic process|pyrimidine nucleotide biosynthetic process|ribonucleoside monophosphate biosynthetic process|urate biosynthetic process	cytosol	ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(3)|lung(11)|upper_aerodigestive_tract(1)	23						ATATGCTATCTGTAGCAGGTG	0.413000													14	104					0	0	0.146539	0	0
GRM1	2911	broad.mit.edu	37	6	146350745	146350745	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:146350745G>C	ENST00000392299.2	+	2	562	c.92G>C	c.(91-93)gGa>gCa	p.G31A	GRM1_ENST00000355289.4_Missense_Mutation_p.G31A|GRM1_ENST00000507907.1_Missense_Mutation_p.G31A|GRM1_ENST00000282753.1_Missense_Mutation_p.G31A|GRM1_ENST00000492807.2_Missense_Mutation_p.G31A|GRM1_ENST00000361719.2_Missense_Mutation_p.G31A			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	31					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTGCTGGCAGGAGCGTCGTCT	0.582000													41	96					0	0	0.139131	0	0
KIAA1462	57608	broad.mit.edu	37	10	30315636	30315636	+	Silent	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:30315636G>T	ENST00000375377.1	-	3	3542	c.3441C>A	c.(3439-3441)ggC>ggA	p.G1147G		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	1147										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTTCCTCCTGCCATAAAAGG	0.617000													33	94					1.66425e-11	2.48797e-11	0.074837	1	0
NOTCH2	4853	broad.mit.edu	37	1	120466412	120466412	+	Silent	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:120466412C>A	ENST00000256646.2	-	26	4926	c.4707G>T	c.(4705-4707)ctG>ctT	p.L1569L	NOTCH2_ENST00000493703.1_5'UTR	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1569	Negative regulatory region (NRR).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCAGGGTACCCAGTGCCCGCA	0.542000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				14	39					1.5842e-08	2.23297e-08	0.105934	1	0
ZDHHC11	79844	broad.mit.edu	37	5	843743	843743	+	Silent	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:843743C>A	ENST00000283441.8	-	4	983	c.600G>T	c.(598-600)ggG>ggT	p.G200G	ZDHHC11_ENST00000424784.2_Silent_p.G200G|ZDHHC11_ENST00000511539.1_5'UTR	NM_024786.2	NP_079062.1	Q9H8X9	ZDH11_HUMAN	zinc finger, DHHC-type containing 11	200						integral to membrane	acyltransferase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|liver(1)|lung(10)|pancreas(1)|prostate(5)|skin(2)|urinary_tract(1)	21			Epithelial(17;0.000445)|all cancers(22;0.00176)|OV - Ovarian serous cystadenocarcinoma(19;0.00227)|Lung(60;0.0863)			TGCGGAGCACCCCGGGGTTCA	0.632000													7	30					0.000442599	0.000511756	0.058154	1	0
OR5W2	390148	broad.mit.edu	37	11	55681285	55681285	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:55681285C>T	ENST00000344514.1	-	1	773	c.774G>A	c.(772-774)atG>atA	p.M258I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GCCGGAAATACATAAAGAGCA	0.443000													38	62					0	0	0.117977	0	0
CTNND2	1501	broad.mit.edu	37	5	11236884	11236884	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:11236884C>A	ENST00000304623.8	-	10	1869	c.1680G>T	c.(1678-1680)caG>caT	p.Q560H	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.Q223H|CTNND2_ENST00000511377.1_Missense_Mutation_p.Q469H|CTNND2_ENST00000359640.2_Missense_Mutation_p.Q560H|CTNND2_ENST00000458100.2_Missense_Mutation_p.Q127H	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	560					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GAAACTGGTGCTGCAACATCT	0.488000													48	155					3.07002e-29	5.13404e-29	0.139131	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103090682	103090682	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:103090682G>A	ENST00000375735.2	+	56	9015	c.8871G>A	c.(8869-8871)aaG>aaA	p.K2957K	DYNC2H1_ENST00000398093.3_Silent_p.K2957K|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2957	Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AAAGACTGAAGCACAGAATAG	0.269000													8	14					0	0	0.080935	0	0
SPTAN1	6709	broad.mit.edu	37	9	131348057	131348057	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:131348057A>G	ENST00000372739.3	+	19	2701	c.2591A>G	c.(2590-2592)aAg>aGg	p.K864R	SPTAN1_ENST00000372731.4_Missense_Mutation_p.K864R|SPTAN1_ENST00000358161.5_Missense_Mutation_p.K864R	NM_001130438.2	NP_001123910.1	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	864					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						GTGAAGGCCAAGCTTCACGAG	0.502000													44	104					0	0	0.139131	0	0
XYLT1	64131	broad.mit.edu	37	16	17294464	17294464	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:17294464T>A	ENST00000261381.6	-	4	1045	c.961A>T	c.(961-963)Atg>Ttg	p.M321L		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	321					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TTGGCTGGCATGTACTCCACG	0.557000													77	169					0	0	0.139131	0	0
IGSF9	57549	broad.mit.edu	37	1	159912758	159912758	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:159912758T>A	ENST00000368094.1	-	3	439	c.242A>T	c.(241-243)tAc>tTc	p.Y81F	IGSF9_ENST00000361509.3_Missense_Mutation_p.Y81F	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	81	Ig-like 1.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			CTTACCCACGTAATCAGGGTC	0.577000													20	31					0	0	0.069288	0	0
MGEA5	10724	broad.mit.edu	37	10	103550754	103550754	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:103550754C>A	ENST00000361464.3	-	14	2748	c.2353G>T	c.(2353-2355)Gat>Tat	p.D785Y	MGEA5_ENST00000439817.1_Missense_Mutation_p.D732Y|MGEA5_ENST00000482611.1_5'UTR|MGEA5_ENST00000357797.5_Missense_Mutation_p.D718Y	NM_012215.3	NP_036347.1	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	785	Histone acetyltransferase activity (By similarity).|Required for histone H4 binding (By similarity).				glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	23		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		GGGGTCACATCTACAGTGCCC	0.458000													12	39					2.27111e-07	3.00111e-07	0.093190	1	0
BMP15	9210	broad.mit.edu	37	X	50658984	50658984	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:50658984A>G	ENST00000252677.3	+	2	556	c.556A>G	c.(556-558)Atc>Gtc	p.I186V		NM_005448.2	NP_005439.2	O95972	BMP15_HUMAN	bone morphogenetic protein 15	186					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(1)	26	Ovarian(276;0.236)					AGAGATGGATATCACACAACT	0.468000													17	76					0	0	0.033300	0	0
SCAF4	57466	broad.mit.edu	37	21	33073388	33073388	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:33073388G>A	ENST00000286835.7	-	7	1079	c.697C>T	c.(697-699)Cag>Tag	p.Q233*	SCAF4_ENST00000434667.3_Nonsense_Mutation_p.Q218*|SCAF4_ENST00000399804.1_Nonsense_Mutation_p.Q233*	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	233						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GTCTTTAACTGAGCTGTGATA	0.448000													18	40					0	0	0.033300	0	0
GRIK2	2898	broad.mit.edu	37	6	102503456	102503456	+	Splice_Site	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:102503456G>A	ENST00000369138.1	+	15	3052		c.e15+1		GRIK2_ENST00000413795.1_Splice_Site|GRIK2_ENST00000369134.4_Splice_Site|GRIK2_ENST00000421544.1_Splice_Site|GRIK2_ENST00000369137.3_Splice_Site|GRIK2_ENST00000318991.6_Splice_Site	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2						glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	ATTGGAAAAGGTAAATGTTAC	0.318000													6	77					0	0	0.029380	0	0
MYO1D	4642	broad.mit.edu	37	17	31107692	31107692	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:31107692C>A	ENST00000318217.5	-	2	510	c.206G>T	c.(205-207)cGt>cTt	p.R69L	MYO1D_ENST00000394649.4_5'UTR|MYO1D_ENST00000583621.1_Missense_Mutation_p.R69L|MYO1D_ENST00000579584.1_Missense_Mutation_p.R69L	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	69	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			ATACAGCTCACGGCCTTTATA	0.448000													12	47					3.07112e-06	3.85191e-06	0.080935	1	0
TRPC5	7224	broad.mit.edu	37	X	111024416	111024416	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:111024416G>A	ENST00000262839.2	-	9	3037	c.2119C>T	c.(2119-2121)Ctg>Ttg	p.L707L		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	707					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTTTGTATCAGGCTGTCAGCA	0.423000													3	96					0	0	0.009096	0	0
WNT2B	7482	broad.mit.edu	37	1	113033704	113033704	+	Splice_Site	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:113033704G>T	ENST00000369686.4	+	2	229		c.e2+1		WNT2B_ENST00000256640.5_Intron	NM_004185.3	NP_004176.2	Q93097	WNT2B_HUMAN	wingless-type MMTV integration site family, member 2B						chondrocyte differentiation|cornea development in camera-type eye|dorsal/ventral axis specification|forebrain regionalization|hemopoietic stem cell proliferation|iris morphogenesis|lens development in camera-type eye|lung induction|male gonad development|neuron differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(2)|skin(1)|stomach(1)	18	Lung SC(450;0.246)	all_cancers(81;7.31e-07)|all_epithelial(167;4.59e-06)|all_lung(203;2.56e-05)|Lung NSC(69;4.38e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		gtttgCAAAGGTACATGATAA	0.458000													3	11					0.014758	0.015885	0.014758	1	0
HIST2H2BA	337875	broad.mit.edu	37	1	120906203	120906203	+	RNA	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:120906203G>A	ENST00000430394.1	+	0	176					NR_027337.1																						CCCGACACCGGCATCTCGTCC	0.612000													5	246					0	0	0.014758	0	0
RP2	6102	broad.mit.edu	37	X	46713151	46713151	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:46713151C>A	ENST00000218340.3	+	2	504	c.343C>A	c.(343-345)Caa>Aaa	p.Q115K		NM_006915.2	NP_008846.2	O75695	XRP2_HUMAN	retinitis pigmentosa 2 (X-linked recessive)	115	C-CAP/cofactor C-like.				cell morphogenesis|CTP biosynthetic process|GTP biosynthetic process|protein folding|UTP biosynthetic process|visual perception	cytoplasm|plasma membrane	ATP binding|GTP binding|GTPase activator activity|nucleoside diphosphate kinase activity|unfolded protein binding			NS(1)|large_intestine(4)|lung(5)|stomach(1)	11						ATTAGCCTGCCAACAATTTCG	0.418000													8	80					1.58986e-06	2.01111e-06	0.069234	1	0
ABCG8	64241	broad.mit.edu	37	2	44071702	44071702	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:44071702C>G	ENST00000272286.2	+	2	210	c.120C>G	c.(118-120)taC>taG	p.Y40*		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	40					cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACTTCACCTACAGTGGCCAGC	0.567000													10	47					0	0	0.069234	0	0
MAGEB4	4115	broad.mit.edu	37	X	30260301	30260301	+	Silent	SNP	C	C	A	rs148486223		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:30260301C>A	ENST00000378982.2	+	1	245	c.49C>A	c.(49-51)Cgg>Agg	p.R17R		NM_002367.3	NP_002358.1	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	17										breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27						GAAACGCCAGCGGACCCGTGG	0.567000													9	45					4.68919e-08	6.36697e-08	0.069234	1	0
TP53	7157	broad.mit.edu	37	17	7578550	7578550	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:7578550G>A	ENST00000420246.2	-	5	512	c.380C>T	c.(379-381)tCc>tTc	p.S127F	TP53_ENST00000359597.4_Missense_Mutation_p.S127F|TP53_ENST00000269305.4_Missense_Mutation_p.S127F|TP53_ENST00000445888.2_Missense_Mutation_p.S127F|TP53_ENST00000413465.2_Missense_Mutation_p.S127F|TP53_ENST00000455263.2_Missense_Mutation_p.S127F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	127	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> P (in sporadic cancers; somatic mutation).|S -> T (in sporadic cancers; somatic mutation).|S -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.S127F(23)|p.0?(8)|p.S127Y(8)|p.S127C(7)|p.Y126_K132delYSPALNK(6)|p.A129fs*20(3)|p.Y126_N131delYSPALN(3)|p.S34C(2)|p.P128fs*42(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.P128fs*18(1)|p.Y126fs*11(1)|p.S127_Q136del10(1)|p.P13fs*18(1)|p.?(1)|p.S34F(1)|p.A36fs*20(1)|p.S127fs*42(1)|p.Y126fs*18(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGGGCAGGGGAGTACTGTAG	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	34					0	0	0.049695	0	0
ESRRB	2103	broad.mit.edu	37	14	76966353	76966353	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:76966353C>A	ENST00000380887.2	+	8	1516	c.1444C>A	c.(1444-1446)Ccc>Acc	p.P482T	RP11-187O7.3_ENST00000554926.1_lincRNA|ESRRB_ENST00000509242.1_Missense_Mutation_p.P482T|ESRRB_ENST00000261532.7_3'UTR			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	482						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TAGTCCAACCCCCCTCAATGA	0.567000													9	16					7.48243e-07	9.67161e-07	0.058154	1	0
CLVS2	134829	broad.mit.edu	37	6	123319300	123319300	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:123319300G>A	ENST00000275162.4	+	2	1713	c.378G>A	c.(376-378)tgG>tgA	p.W126*	CLVS2_ENST00000368438.1_Intron	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	126	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity	p.W126C(2)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						CTGCCAATTGGGATCAGAGCA	0.468000													19	59					0	0	0.038395	0	0
MUC17	140453	broad.mit.edu	37	7	100683857	100683857	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:100683857A>G	ENST00000306151.4	+	3	9224	c.9160A>G	c.(9160-9162)Agc>Ggc	p.S3054G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3054	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TATACCTGTCAGCACCACGCC	0.488000													46	132					0	0	0.139131	0	0
XPO7	23039	broad.mit.edu	37	8	21860756	21860756	+	Silent	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:21860756C>T	ENST00000434536.1	+	26	3099	c.2997C>T	c.(2995-2997)atC>atT	p.I999I	XPO7_ENST00000433566.4_Silent_p.I991I|XPO7_ENST00000252512.9_Silent_p.I990I			Q9UIA9	XPO7_HUMAN	exportin 7	990					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		TGAACATCATCATCTTTGAAG	0.448000													7	11					0	0	0.058154	0	0
AADAC	13	broad.mit.edu	37	3	151545721	151545721	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:151545721C>T	ENST00000232892.6	+	5	1087	c.961C>T	c.(961-963)Cct>Tct	p.P321S	RP11-454C18.2_ENST00000475855.1_RNA|RP11-454C18.2_ENST00000483843.2_RNA	NM_001086.2	NP_001077.2	P22760	AAAD_HUMAN	arylacetamide deacetylase	321					positive regulation of triglyceride catabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	carboxylesterase activity|deacetylase activity|serine hydrolase activity|triglyceride lipase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(5)|skin(2)	19		Myeloproliferative disorder(1037;0.0255)|all_neural(597;0.112)	LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)			GAGGGCAGCCCCTTTGTTGGC	0.423000													36	41					0	0	0.069456	0	0
ANGEL1	23357	broad.mit.edu	37	14	77272897	77272897	+	Silent	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:77272897C>A	ENST00000251089.2	-	5	1354	c.1242G>T	c.(1240-1242)gtG>gtT	p.V414V		NM_015305.3	NP_056120.2	Q9UNK9	ANGE1_HUMAN	angel homolog 1 (Drosophila)	414										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(2)|lung(9)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	22			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CCACCTTGTCCACTTCCGCCA	0.572000													16	38					1.99824e-07	2.65237e-07	0.033300	1	0
EXOC4	60412	broad.mit.edu	37	7	133059673	133059673	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:133059673G>T	ENST00000253861.4	+	7	1128	c.1099G>T	c.(1099-1101)Gta>Tta	p.V367L	EXOC4_ENST00000539845.1_Missense_Mutation_p.V266L|EXOC4_ENST00000393161.2_Missense_Mutation_p.V367L	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	367					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GCAGGACACTGTAGTGACTCC	0.458000													9	28					0.000274275	0.000318374	0.047766	1	0
ZNF645	158506	broad.mit.edu	37	X	22291637	22291637	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:22291637C>A	ENST00000323684.1	+	1	573	c.529C>A	c.(529-531)Cta>Ata	p.L177I		NM_152577.3	NP_689790.1	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	177						intracellular	zinc ion binding			cervix(1)|endometrium(4)|large_intestine(8)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	27						CAGGGACCATCTAAGCTATAT	0.458000													26	225					0.00127121	0.00143618	0.125774	1	0
CHRM1	1128	broad.mit.edu	37	11	62677713	62677713	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:62677713G>T	ENST00000306960.3	-	2	1401	c.860C>A	c.(859-861)tCc>tAc	p.S287Y	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	287					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	GGATGTGAGGGACTCCATGGA	0.652000													46	86					1.32667e-27	2.20615e-27	0.139131	1	0
SMARCA1	6594	broad.mit.edu	37	X	128649931	128649931	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:128649931G>C	ENST00000371122.4	-	4	598	c.469C>G	c.(469-471)Cta>Gta	p.L157V	SMARCA1_ENST00000478420.1_5'UTR|SMARCA1_ENST00000371121.3_Missense_Mutation_p.L157V|SMARCA1_ENST00000371123.1_Missense_Mutation_p.L157V	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	157					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						TCAGACAGTAGCTCTTCATCT	0.363000													20	57					0	0	0.091800	0	0
AKAP4	8852	broad.mit.edu	37	X	49957154	49957154	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:49957154C>A	ENST00000376056.2	-	5	2333	c.2183G>T	c.(2182-2184)aGg>aTg	p.R728M	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Missense_Mutation_p.R737M|AKAP4_ENST00000376058.2_Missense_Mutation_p.R354M|AKAP4_ENST00000376064.3_Missense_Mutation_p.R728M			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	737					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TCTGGTGCCCCTGAAATTGGG	0.463000													3	67					0.115264	0.121417	0.115264	1	0
ADNP	23394	broad.mit.edu	37	20	49518564	49518564	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr20:49518564G>C	ENST00000396029.3	-	4	758	c.191C>G	c.(190-192)aCg>aGg	p.T64R	ADNP_ENST00000349014.3_Missense_Mutation_p.T64R|ADNP_ENST00000396032.3_Missense_Mutation_p.T64R|ADNP_ENST00000371602.4_Missense_Mutation_p.T64R	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	64						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						CTGGTTTTTCGTAAGTGATGG	0.418000													26	75					0	0	0.054565	0	0
EGF	1950	broad.mit.edu	37	4	110902110	110902110	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:110902110G>T	ENST00000265171.5	+	15	2795	c.2350G>T	c.(2350-2352)Gat>Tat	p.D784Y	EGF_ENST00000503392.1_Missense_Mutation_p.D784Y|EGF_ENST00000509793.1_Missense_Mutation_p.D742Y	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	784			D -> V (in dbSNP:rs11569017).		angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	TCTGGCTCTGGATGGTCATCA	0.413000													45	126					7.88023e-25	1.3031e-24	0.139131	1	0
SPATA19	219938	broad.mit.edu	37	11	133715076	133715076	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:133715076C>A	ENST00000299140.3	-	2	142	c.88G>T	c.(88-90)Gtt>Ttt	p.V30F	SPATA19_ENST00000532889.1_Missense_Mutation_p.V30F	NM_174927.1	NP_777587.1	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19	30					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane				cervix(1)|endometrium(2)|large_intestine(2)|lung(5)|prostate(1)	11	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		CTTTCCACAACGTCAATGTCC	0.418000													11	31					5.50884e-06	6.85133e-06	0.093190	1	0
ZNF804A	91752	broad.mit.edu	37	2	185798372	185798372	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:185798372G>T	ENST00000302277.6	+	3	892	c.298G>T	c.(298-300)Gca>Tca	p.A100S		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	100						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TCGAAATGTAGCATCTAAATC	0.373000													13	42					3.27435e-08	4.4664e-08	0.119110	1	0
DUOX2	50506	broad.mit.edu	37	15	45388110	45388110	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:45388110G>T	ENST00000389039.6	-	30	4381	c.3996C>A	c.(3994-3996)caC>caA	p.H1332Q	DUOX2_ENST00000603300.1_Missense_Mutation_p.H1332Q			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	1332	FAD-binding FR-type.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		CTGCCCGGATGTGCAGGCTGA	0.642000													12	66					1.61879e-10	2.38389e-10	0.093190	1	0
CHST1	8534	broad.mit.edu	37	11	45671313	45671313	+	Silent	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:45671313G>A	ENST00000308064.2	-	4	1831	c.1161C>T	c.(1159-1161)atC>atT	p.I387I		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	387					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		CCGAGGCGGCGATCTTGTAGC	0.701000													6	42					0	0	0.029380	0	0
APOB	338	broad.mit.edu	37	2	21255315	21255315	+	Silent	SNP	G	G	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:21255315G>C	ENST00000233242.1	-	10	1390	c.1263C>G	c.(1261-1263)ccC>ccG	p.P421P	APOB_ENST00000399256.4_Silent_p.P421P	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	421	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCTGTGCTGAGGGCTCGGGGA	0.587000													36	97					0	0	0.080422	0	0
FAM149A	25854	broad.mit.edu	37	4	187088124	187088124	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:187088124C>G	ENST00000356371.5	+	12	2040	c.2040C>G	c.(2038-2040)taC>taG	p.Y680*	FAM149A_ENST00000502970.1_Nonsense_Mutation_p.Y389*|FAM149A_ENST00000227065.4_Nonsense_Mutation_p.Y389*|FAM149A_ENST00000503432.1_Nonsense_Mutation_p.Y389*|FAM149A_ENST00000514153.1_Nonsense_Mutation_p.Y389*|FAM149A_ENST00000389354.5_Nonsense_Mutation_p.Y389*			A5PLN7	F149A_HUMAN	family with sequence similarity 149, member A	680										breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(2)	25		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.19e-10)|BRCA - Breast invasive adenocarcinoma(30;1.22e-05)|GBM - Glioblastoma multiforme(59;0.000122)|STAD - Stomach adenocarcinoma(60;0.000288)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.166)		TCATTTAGTACAGAGGAAGGC	0.413000													5	33					0	0	0.021553	0	0
FDPS	2224	broad.mit.edu	37	1	155289625	155289625	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:155289625G>A	ENST00000356657.6	+	10	1127	c.965G>A	c.(964-966)gGc>gAc	p.G322D	RUSC1-AS1_ENST00000543656.1_RNA|FDPS_ENST00000368356.4_Missense_Mutation_p.G322D|RUSC1-AS1_ENST00000443642.1_RNA|RUSC1-AS1_ENST00000446880.1_RNA|FDPS_ENST00000447866.1_Missense_Mutation_p.G256D	NM_001135821.1	NP_001129293.1	P14324	FPPS_HUMAN	farnesyl diphosphate synthase	322					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	10	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	AGTGTGACCGGCAAAATTGGC	0.567000													7	769					0	0	0.029380	0	0
RP1-37J18.2	0	broad.mit.edu	37	1	4634683	4634684	+	RNA	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:4634683_4634684insG	ENST00000420522.1	+	0	205																											agagagtgtgtgggggggtgag	0.480													2	4	---	---	---	---					
STPG1	90529	broad.mit.edu	37	1	24718090	24718090	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:24718090delT	ENST00000374409.1	-	3	404	c.150delA	c.(148-150)aafs	p.K50fs	STPG1_ENST00000003583.8_Intron|STPG1_ENST00000468303.1_5'UTR|STPG1_ENST00000337248.4_Frame_Shift_Del_p.K50fs|STPG1_ENST00000440416.1_Intron	NM_001199012.1	NP_001185941.1			sperm-tail PG-rich repeat containing 1																		TATTGAATCCTTTTTTTTCTG	0.388											OREG0013240	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
ADC	113451	broad.mit.edu	37	1	33583668	33583669	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:33583668_33583669insG	ENST00000294517.6	+	11	1782_1783	c.1195_1196insG	c.(1195-1197)gggfs	p.G399fs	ADC_ENST00000398167.1_Frame_Shift_Ins_p.G419fs|ADC_ENST00000373443.3_Frame_Shift_Ins_p.G399fs|ADC_ENST00000373441.1_Frame_Shift_Ins_p.G419fs|ADC_ENST00000484656.1_3'UTR	NM_052998.2	NP_443724.1	Q96A70	ADC_HUMAN	arginine decarboxylase	399					polyamine biosynthetic process|spermatogenesis	cytosol	arginine decarboxylase activity			NS(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)	11		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)			L-Arginine(DB00125)|Pyridoxal Phosphate(DB00114)	TTCCCCCTTTTGGGGGACCCAG	0.619													13	44	---	---	---	---					
RP11-466L17.1	0	broad.mit.edu	37	1	56112360	56112361	+	RNA	DEL	AC	AC	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:56112360_56112361delAC	ENST00000422374.1	+	0	240																											aaaaaaaaagacaaacttcaaa	0.277													3	4	---	---	---	---					
LOC101926964	101926964	broad.mit.edu	37	1	61281964	61281965	+	RNA	INS	-	-	CA	rs77445074	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:61281964_61281965insCA	ENST00000423403.1	-	0	249																											acacacacactcacacacacac	0.406													3	6	---	---	---	---					
USP33	23032	broad.mit.edu	37	1	78204952	78204952	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:78204952delG	ENST00000370793.1	-	6	788	c.442delC	c.(442-444)agfs	p.Q148fs	USP33_ENST00000370792.3_Frame_Shift_Del_p.Q148fs|USP33_ENST00000357428.1_Frame_Shift_Del_p.Q148fs|USP33_ENST00000370794.3_Frame_Shift_Del_p.Q117fs	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	148					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						ATTATTACCTGGACACTGTTT	0.348													14	52	---	---	---	---					
LOC101927587	101927587	broad.mit.edu	37	1	84155364	84155364	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:84155364delA	ENST00000417975.1	-	0	280																											ggcctttgggaagtaattagg	0.512													2	4	---	---	---	---					
RP4-651E10.4	0	broad.mit.edu	37	1	87051400	87051401	+	RNA	INS	-	-	TCTC	rs10632360		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:87051400_87051401insTCTC	ENST00000456587.1	-	0	294																											ctctctctctgtctctctctct	0.480													3	5	---	---	---	---					
LINC01307	104355286	broad.mit.edu	37	1	101833606	101833607	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:101833606_101833607insC	ENST00000444327.1	+	0	137																											AGATGCTCCCGCCCCCTCCAAA	0.426													2	4	---	---	---	---					
RP11-439A17.10	0	broad.mit.edu	37	1	120917198	120917198	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:120917198delT	ENST00000426275.1	+	0	75																											TAATGTTTCCTACTAATAAAC	0.318													3	3	---	---	---	---					
LOC101928979	101928979	broad.mit.edu	37	1	145380919	145380921	+	RNA	DEL	CTT	CTT	-	rs55940905		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:145380919_145380921delCTT	ENST00000419817.1	-	0	307																											aaatactgtgcttttttccactg	0.552													3	4	---	---	---	---					
LOC101928009	101928009	broad.mit.edu	37	1	153157816	153157816	+	RNA	DEL	T	T	-	rs71093263		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:153157816delT	ENST00000427145.1	+	0	656																											ggtcctgggcttttttttttt	0.393													3	4	---	---	---	---					
CRTC2	200186	broad.mit.edu	37	1	153924672	153924673	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:153924672_153924673insC	ENST00000368633.1	-	10	945_946	c.818_819insG	c.(817-819)gtcfs	p.V273fs	CRTC2_ENST00000368630.3_Intron	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	273					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAGGTAGGGAGCCCCCCGTGTT	0.574													7	287	---	---	---	---					
LOC646268	646268	broad.mit.edu	37	1	158105263	158105263	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:158105263delA	ENST00000414848.1	-	0	142					NR_033946.1																						CCTTTGGCCTAAGGGAttctt	0.423													2	4	---	---	---	---					
RP11-297H3.3	0	broad.mit.edu	37	1	170183980	170183981	+	RNA	DEL	CA	CA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr1:170183980_170183981delCA	ENST00000439184.1	+	0	304																											gtctctctgtcacacacacaca	0.465													3	6	---	---	---	---					
LINC01115	339822	broad.mit.edu	37	2	838323	838323	+	RNA	DEL	G	G	-	rs67101877		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:838323delG	ENST00000414556.1	-	0	548					NR_033880.1																						GCTCCTGCAAGGGCGCAGTGG	0.602													4	2	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	2956399	2956400	+	RNA	INS	-	-	AGAC	rs58498291		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:2956399_2956400insAGAC	ENST00000457478.1	-	0	594																											AAGGGAGagagagacagacaga	0.436													4	4	---	---	---	---					
LINC01304	100505964	broad.mit.edu	37	2	4019609	4019610	+	RNA	INS	-	-	TGTG	rs55907324		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:4019609_4019610insTGTG	ENST00000454455.1	-	0	526					NR_037881.1																						tgagtgtgtgttgtgtgtgtgt	0.475													4	7	---	---	---	---					
LOC400940	400940	broad.mit.edu	37	2	6097038	6097038	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:6097038delT	ENST00000431188.1	+	0	134																											ccagtgtttcttttttttttt	0.363													3	3	---	---	---	---					
ID2-AS1	100506299	broad.mit.edu	37	2	8808487	8808487	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:8808487delT	ENST00000412712.1	-	0	801																											aagggatgaatggaaggaagg	0.478													2	4	---	---	---	---					
AC099344.2	0	broad.mit.edu	37	2	11499077	11499078	+	RNA	DEL	TT	TT	-	rs59829548		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:11499077_11499078delTT	ENST00000430897.1	-	0	539																											tctttctttctttttttttttt	0.411													3	3	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12149867	12149868	+	RNA	DEL	CT	CT	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:12149867_12149868delCT	ENST00000412294.1	+	0	197																											CTCCCAGTCCCTCTCTCTCTGC	0.421													2	4	---	---	---	---					
HS1BP3	64342	broad.mit.edu	37	2	20840863	20840864	+	Frame_Shift_Ins	INS	-	-	G	rs77941615	byFrequency	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:20840863_20840864insG	ENST00000402541.1	-	3	289_290	c.275_276insC	c.(274-276)cctfs	p.P92fs	HS1BP3_ENST00000304031.3_Frame_Shift_Ins_p.P92fs|HS1BP3_ENST00000406618.3_Frame_Shift_Ins_p.P92fs			Q53T59	H1BP3_HUMAN	HCLS1 binding protein 3	92	PX.				cell communication		phosphatidylinositol binding			endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	15	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCCTGGGTAGTGGGGGGAGGCT	0.540													8	295	---	---	---	---					
AC067959.1	0	broad.mit.edu	37	2	21447434	21447435	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:21447434_21447435insT	ENST00000457901.1	+	0	110																											TATGATTTCTATTTTTTGTAAG	0.322													2	4	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34057011	34057011	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:34057011delC	ENST00000366209.2	+	0	68																											ccaactaggtctaaggataga	0.353													4	3	---	---	---	---					
CYP1B1-AS1	285154	broad.mit.edu	37	2	38399375	38399386	+	RNA	DEL	AGCCTCTTCTTC	AGCCTCTTCTTC	-	rs113879879		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:38399375_38399386delAGCCTCTTCTTC	ENST00000413828.2	+	0	190					NR_027252.1																						TGCTTACCTAAGCCTCTTCTTCAGCCTCTTCT	0.448													2	4	---	---	---	---					
AC009229.5	0	broad.mit.edu	37	2	38445152	38445153	+	RNA	INS	-	-	CTTC	rs113722114	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:38445152_38445153insCTTC	ENST00000450854.1	-	0	533																											TTTTGCCCTGTCTTATGATTCA	0.455													3	5	---	---	---	---					
SLC8A1-AS1	100128590	broad.mit.edu	37	2	40077829	40077830	+	RNA	INS	-	-	ATAA	rs3032305	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:40077829_40077830insATAA	ENST00000599740.1	+	0	73																											agtaagaatgtataaatgttct	0.252													3	3	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51709054	51709054	+	RNA	DEL	T	T	-	rs34731070		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:51709054delT	ENST00000440698.1	+	0	694																											CCTCTGCTACttttttttttt	0.378													4	3	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51802039	51802040	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:51802039_51802040insA	ENST00000440698.1	+	0	753																											tttcattgggtaaaaaatctga	0.356													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52591079	52591079	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:52591079delC	ENST00000440698.1	+	0	2999																											tttgacaagtccctttttcct	0.323													2	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60155791	60155792	+	RNA	INS	-	-	CCA	rs149876856	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:60155791_60155792insCCA	ENST00000606382.1	-	0	110																											tccctcaatttcaacaagcttg	0.376													4	5	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60232626	60232627	+	RNA	INS	-	-	T	rs71883693		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:60232626_60232627insT	ENST00000606382.1	-	0	110																											atcctagccacttttttttttt	0.381													4	2	---	---	---	---					
AC022201.4	0	broad.mit.edu	37	2	70640225	70640227	+	RNA	DEL	AGA	AGA	-	rs72540727		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:70640225_70640227delAGA	ENST00000452525.1	+	0	203																											GGAGGTGGGGAGAAGGACACCTG	0.542													4	6	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91898831	91898831	+	RNA	DEL	A	A	-	rs79527766		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:91898831delA	ENST00000436174.1	-	0	168																											cctgtctcagaaaaaaaaaaa	0.423													2	4	---	---	---	---					
AFF3	3899	broad.mit.edu	37	2	100210335	100210340	+	In_Frame_Del	DEL	GGCTGA	GGCTGA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:100210335_100210340delGGCTGA	ENST00000317233.4	-	14	2018_2023	c.1783_1788delTCAGCC	c.(1783-1788)del	p.SA595del	AFF3_ENST00000409579.1_In_Frame_Del_p.SA620del|AFF3_ENST00000409236.1_In_Frame_Del_p.SA595del|AFF3_ENST00000356421.2_In_Frame_Del_p.SA620del	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	595					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						CGCCGTCCCCGGCTGAGGTCCTCTCG	0.782													4	7	---	---	---	---					
AC097532.2	0	broad.mit.edu	37	2	133050244	133050245	+	RNA	DEL	TG	TG	-	rs8179688		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:133050244_133050245delTG	ENST00000440802.1	-	0	60																											gttttctggctgtttttttttt	0.297													3	5	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164921908	164921909	+	RNA	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:164921908_164921909insG	ENST00000429636.1	-	0	196																											GGGGTGGAGTTGGGGGGGAAAG	0.475													2	4	---	---	---	---					
HAGLR	401022	broad.mit.edu	37	2	177053045	177053046	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:177053045_177053046insC	ENST00000417086.1	-	0	122				HOXD-AS1_ENST00000452365.1_RNA|HOXD-AS1_ENST00000425005.1_RNA|HOXD-AS1_ENST00000413969.1_RNA																							CGAGGGACTAGCCCCCCCCACG	0.673													3	3	---	---	---	---					
AC079305.11	0	broad.mit.edu	37	2	177895009	177895010	+	RNA	INS	-	-	GT	rs143327095	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:177895009_177895010insGT	ENST00000441205.1	-	0	370																											CATGTGCGCAAgtgtgtgtgtg	0.455													6	5	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217687448	217687448	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:217687448delT	ENST00000447289.1	+	0	510																											ccagcttgaattttttttttt	0.428													3	3	---	---	---	---					
TNS1	7145	broad.mit.edu	37	2	218844252	218844255	+	RNA	DEL	ACAC	ACAC	-	rs67336490		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:218844252_218844255delACAC	ENST00000450996.1	+	0	138																											AAacacacagacacacacacacac	0.480													7	0	---	---	---	---					
AC009410.1	0	broad.mit.edu	37	2	229415045	229415046	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:229415045_229415046insC	ENST00000432481.2	-	0	144																											AAGAATTAATACCCCCCCCTCC	0.356													2	4	---	---	---	---					
LINC01237	101927289	broad.mit.edu	37	2	242967743	242967743	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr2:242967743delT	ENST00000415434.1	+	0	310				AC093642.4_ENST00000412193.1_lincRNA																							ggagctgatgttggggaagta	0.498													2	4	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	653707	653708	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:653707_653708insA	ENST00000420823.1	+	0	176																											ttggtagcttgaaggggatggc	0.391													4	5	---	---	---	---					
AC026188.1	0	broad.mit.edu	37	3	3504465	3504466	+	RNA	INS	-	-	GGG	rs66764310	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:3504465_3504466insGGG	ENST00000455703.1	-	0	59																											CTAAGtttattggagagtctcc	0.361													3	3	---	---	---	---					
AC098973.2	0	broad.mit.edu	37	3	27886375	27886375	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:27886375delT	ENST00000414382.1	+	0	336																											aatgtgactcttttaatttct	0.294													2	4	---	---	---	---					
CTD-2185K10.1	0	broad.mit.edu	37	3	59082388	59082389	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:59082388_59082389insC	ENST00000487624.1	+	0	117																											tccctccccttccccccaacaa	0.480													2	4	---	---	---	---					
PTPRG-AS1	100506994	broad.mit.edu	37	3	62341655	62341656	+	RNA	DEL	AG	AG	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:62341655_62341656delAG	ENST00000490916.1	-	0	135				PTPRG-AS1_ENST00000495542.1_RNA																							caaaacatgcagagagagagag	0.460													3	3	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67956776	67956776	+	RNA	DEL	A	A	-	rs11359356		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:67956776delA	ENST00000482677.1	+	0	1653																											CATAAAAAGGAAAAAAAAAAA	0.398													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82292115	82292115	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:82292115delT	ENST00000470263.1	+	0	472																											ttatgcaagattttttttttt	0.408													3	3	---	---	---	---					
LOC101929717	101929717	broad.mit.edu	37	3	112862458	112862459	+	RNA	INS	-	-	C	rs141030854	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:112862458_112862459insC	ENST00000490139.1	-	0	1239_1240				RP11-572M11.4_ENST00000496389.1_RNA																							AGCCCAGTCTTCCAGTCTAGGC	0.495													3	3	---	---	---	---					
LOC100507291	100507291	broad.mit.edu	37	3	139200297	139200300	+	RNA	DEL	TATC	TATC	-	rs60961300		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:139200297_139200300delTATC	ENST00000515247.1	+	0	317																											TTTATTTGTTTATCTATTCACATT	0.284													4	2	---	---	---	---					
RP11-680B3.2	0	broad.mit.edu	37	3	148631298	148631298	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:148631298delT	ENST00000488190.1	-	0	66																											AGGCAGAGGGTTTTTTTTTTA	0.398													2	4	---	---	---	---					
RP11-167H9.4	0	broad.mit.edu	37	3	149916662	149916663	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:149916662_149916663insC	ENST00000489690.1	+	0	212				RP11-167H9.4_ENST00000487840.1_RNA																							TATTTGCATTACCCCCAAAGAA	0.332													2	4	---	---	---	---					
CLRN1-AS1	116933	broad.mit.edu	37	3	150583280	150583281	+	RNA	INS	-	-	GT	rs67716332	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:150583280_150583281insGT	ENST00000476886.1	+	0	123																											AGTAATAAAAAgtgtgtgtgtg	0.421											OREG0015880	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	3	---	---	---	---					
CLRN1-AS1	116933	broad.mit.edu	37	3	150691602	150691603	+	RNA	DEL	TG	TG	-	rs66818841		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:150691602_150691603delTG	ENST00000476886.1	+	0	123				CLRN1-AS1_ENST00000465576.1_RNA|RP11-166N6.2_ENST00000469268.1_RNA																							GACACAGGACtgtgtgtgtgtg	0.411													2	4	---	---	---	---					
RP11-362A9.3	0	broad.mit.edu	37	3	152190599	152190600	+	RNA	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:152190599_152190600insG	ENST00000463255.1	-	0	59																											TTACACTTTCAGGGGGCAGCTA	0.455													2	4	---	---	---	---					
RP11-71H9.2	0	broad.mit.edu	37	3	164399393	164399393	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:164399393delG	ENST00000486767.1	-	0	222																											AACCCCAGGTGGGAGTCAAAT	0.308													2	4	---	---	---	---					
LINC01208	100505547	broad.mit.edu	37	3	176345540	176345540	+	RNA	DEL	G	G	-	rs11914830		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:176345540delG	ENST00000434969.1	-	0	283																											aaggaaggaaggaaagagaga	0.388													2	4	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177400510	177400511	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:177400510_177400511insT	ENST00000442937.1	+	0	428					NR_047568.1																						CCTCCCTGTACTTTTTTTTGGG	0.356													2	4	---	---	---	---					
LOC253573	253573	broad.mit.edu	37	3	186195859	186195859	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:186195859delT	ENST00000427914.1	-	0	974				RP11-48F14.2_ENST00000456535.1_lincRNA	NR_033844.1																						atcagaataattttttcctta	0.463													2	4	---	---	---	---					
LOC647323	647323	broad.mit.edu	37	3	193692858	193692859	+	RNA	INS	-	-	AC	rs141019825	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr3:193692858_193692859insAC	ENST00000397645.2	-	0	75					NR_033944.1																						CGTGCGTGCATACACACACACA	0.579											OREG0015991	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	1	---	---	---	---					
LINC01182	101929071	broad.mit.edu	37	4	13724530	13724531	+	RNA	DEL	GG	GG	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:13724530_13724531delGG	ENST00000510907.1	+	0	281																											GGTACAATCTGGGCAGAAGAAT	0.391													2	4	---	---	---	---					
RP11-103J17.1	0	broad.mit.edu	37	4	37093776	37093776	+	RNA	DEL	A	A	-	rs35490571		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:37093776delA	ENST00000508199.1	+	0	56																											ttgtctggggaagactttatt	0.328													4	3	---	---	---	---					
RP11-25H12.1	0	broad.mit.edu	37	4	66897821	66897821	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:66897821delA	ENST00000508572.1	+	0	463																											caaccaaagcaaaaatggaca	0.393													2	4	---	---	---	---					
LINC01088	100505875	broad.mit.edu	37	4	79973054	79973054	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:79973054delG	ENST00000509088.1	+	0	182				RP11-438E5.1_ENST00000510667.1_RNA	NR_038342.1																						AGATATTTATGGGAGTACTGA	0.408													2	4	---	---	---	---					
PPP3CA	5530	broad.mit.edu	37	4	101947129	101947149	+	In_Frame_Del	DEL	TGCGAGGCGGCATCCTCTCAT	TGCGAGGCGGCATCCTCTCAT	-	rs151291665		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:101947129_101947149delTGCGAGGCGGCATCCTCTCAT	ENST00000394854.3	-	14	2122_2142	c.1439_1459delATGAGAGGATGCCGCCTCGCA	c.(1438-1461)aga>a	p.NERMPPRR480del	PPP3CA_ENST00000512215.1_In_Frame_Del_p.NERMPPRR248del|PPP3CA_ENST00000523694.2_In_Frame_Del_p.NERMPPRR413del|PPP3CA_ENST00000394853.4_In_Frame_Del_p.NERMPPRR470del|PPP3CA_ENST00000507176.1_In_Frame_Del_p.NERMPPRR382del|PPP3CA_ENST00000323055.6_In_Frame_Del_p.NERMPPRR428del	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	480	Inhibitory domain.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding	p.R487G(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		ATGGCATCTCTGCGAGGCGGCATCCTCTCATTAATTCGGTC	0.452													22	162	---	---	---	---					
RP11-556I14.2	0	broad.mit.edu	37	4	105814472	105814472	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:105814472delA	ENST00000515127.1	-	0	366																											ctgagacaggaaaaaAGGGGT	0.383													2	4	---	---	---	---					
RP11-138I17.1	0	broad.mit.edu	37	4	137963953	137963953	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:137963953delA	ENST00000505736.1	-	0	103																											gaattgaaagaaggtgaaata	0.284													2	4	---	---	---	---					
RP13-578N3.3	0	broad.mit.edu	37	4	144644693	144644693	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:144644693delG	ENST00000499587.2	+	0	35																											agaccagcctggtcaacatag	0.527													2	4	---	---	---	---					
RP11-51M24.1	0	broad.mit.edu	37	4	175276863	175276863	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:175276863delC	ENST00000508815.1	-	0	269																											TAGATGAACTCCCATATGGCA	0.358													3	4	---	---	---	---					
RP11-130F10.1	0	broad.mit.edu	37	4	178396183	178396185	+	RNA	DEL	TTG	TTG	-	rs72127894		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:178396183_178396185delTTG	ENST00000507023.1	+	0	581																											CTGCATTACTttgttgttgttgt	0.404													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190808280	190808280	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr4:190808280delC	ENST00000511785.1	-	0	231																											GAAAGGCAGGCTTAGCCAAGT	0.428													4	7	---	---	---	---					
RP11-259O2.2	0	broad.mit.edu	37	5	1964565	1964565	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:1964565delG	ENST00000511698.1	-	0	242																											cacagactgaggtggcacagc	0.562													2	4	---	---	---	---					
LINC01019	285577	broad.mit.edu	37	5	3516445	3516446	+	RNA	INS	-	-	G	rs111513365		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:3516445_3516446insG	ENST00000505443.1	-	0	459					NR_033898.1																						tggaaggcaaagggggggggca	0.515													4	3	---	---	---	---					
RP11-445O3.2	0	broad.mit.edu	37	5	4491412	4491413	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:4491412_4491413insC	ENST00000507435.1	-	0	532																											GGGAGCTCCTGCCCCTGGAGCT	0.485													2	4	---	---	---	---					
RP11-445O3.2	0	broad.mit.edu	37	5	4651584	4651585	+	RNA	DEL	GA	GA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:4651584_4651585delGA	ENST00000507435.1	-	0	429																											ATATGCTTGTGAGATCAAAATG	0.406													2	4	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	6963975	6963976	+	RNA	INS	-	-	T	rs34000296	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:6963975_6963976insT	ENST00000512838.1	+	0	69																											TGGTGTATCTATTTTTTTTTCA	0.347													4	4	---	---	---	---					
CTD-2256P15.4	0	broad.mit.edu	37	5	10266957	10266960	+	RNA	DEL	TGAA	TGAA	-	rs56191713		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:10266957_10266960delTGAA	ENST00000606194.1	-	0	298_301																											tttttttctctgaatgttctcaac	0.397													2	4	---	---	---	---					
RP11-124N3.3	0	broad.mit.edu	37	5	19057275	19057282	+	RNA	DEL	ATTTGTAT	ATTTGTAT	-	rs55986213		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:19057275_19057282delATTTGTAT	ENST00000504827.1	-	0	289																											CTGAAGTTGCATTTGTATATTTGTATTC	0.423													3	5	---	---	---	---					
RP11-2N5.2	0	broad.mit.edu	37	5	117914425	117914426	+	RNA	DEL	TC	TC	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:117914425_117914426delTC	ENST00000513366.1	+	0	267																											cctgtctctatctctctctctc	0.505													2	4	---	---	---	---					
CTB-57H20.1	0	broad.mit.edu	37	5	143116237	143116237	+	RNA	DEL	A	A	-	rs61655116		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:143116237delA	ENST00000503323.1	+	0	379																											atctccaaagaaaaaaaaaaa	0.463													2	4	---	---	---	---					
CTC-295J13.3	0	broad.mit.edu	37	5	147621088	147621089	+	RNA	DEL	AA	AA	-	rs74393250		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:147621088_147621089delAA	ENST00000513133.1	+	0	77																											CACTTCTACCaaaaaaaaaaaa	0.292													3	3	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	164485934	164485934	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr5:164485934delA	ENST00000519570.1	+	0	451				CTC-340A15.2_ENST00000519267.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000522646.1_RNA																							CAGaaaaaagaaaaaaaaaga	0.313													2	4	---	---	---	---					
LY86-AS1	285780	broad.mit.edu	37	6	6396374	6396374	+	RNA	DEL	A	A	-	rs71671755		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:6396374delA	ENST00000435641.1	-	0	639				LY86-AS1_ENST00000429345.1_RNA|LY86-AS1_ENST00000447858.1_RNA																							CAGAAAAAAGAAAAAAAAAAA	0.378													2	4	---	---	---	---					
ZNRD1-AS1	80862	broad.mit.edu	37	6	30019853	30019853	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:30019853delT	ENST00000376797.3	-	0	259				ZNRD1-AS1_ENST00000422224.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000421692.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000437417.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							gttgattccctgtctttgcta	0.363													2	4	---	---	---	---					
XXbac-BPG27H4.8	0	broad.mit.edu	37	6	30811387	30811387	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:30811387delT	ENST00000442852.1	-	0	305																											cgttcctagcttttcctgctt	0.363													2	4	---	---	---	---					
DST	667	broad.mit.edu	37	6	56490042	56490042	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:56490042delC	ENST00000370754.5	-	34	4643	c.4644delG	c.(4642-4644)atfs	p.M1548fs	DST_ENST00000421834.2_Frame_Shift_Del_p.M1370fs|DST_ENST00000370765.6_Frame_Shift_Del_p.M1044fs|DST_ENST00000370769.4_Frame_Shift_Del_p.M1370fs|DST_ENST00000446842.2_Frame_Shift_Del_p.M1044fs|DST_ENST00000370788.2_Frame_Shift_Del_p.M1370fs|DST_ENST00000361203.3_Frame_Shift_Del_p.M1370fs|DST_ENST00000312431.6_Frame_Shift_Del_p.M1370fs|DST_ENST00000518935.1_Frame_Shift_Del_p.M1044fs|DST_ENST00000244364.6_Frame_Shift_Del_p.M1044fs			Q03001	DYST_HUMAN	dystonin	1370					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CCCGGTAGGTCATTGTTTGTA	0.338													7	42	---	---	---	---					
RP1-23E21.2	0	broad.mit.edu	37	6	93804752	93804753	+	RNA	DEL	AC	AC	-	rs34680884		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:93804752_93804753delAC	ENST00000452624.1	+	0	144																											aaagTACAGGacacacacacac	0.366													2	4	---	---	---	---					
RP11-436D23.1	0	broad.mit.edu	37	6	98446873	98446874	+	RNA	DEL	TG	TG	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:98446873_98446874delTG	ENST00000607823.1	+	0	267																											tgtgtgtgtatgtgtgtgtgtg	0.431													2	4	---	---	---	---					
RP11-436D23.1	0	broad.mit.edu	37	6	98465660	98465660	+	RNA	DEL	A	A	-	rs76508926		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:98465660delA	ENST00000607823.1	+	0	267																											ATCAAAATCTAAAAAAAAAAA	0.343													2	4	---	---	---	---					
TRDN	10345	broad.mit.edu	37	6	123786033	123786033	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:123786033delA	ENST00000546248.1	-	9	1022	c.889delT	c.(889-891)ctfs	p.S297fs	TRDN_ENST00000334268.4_Intron|RP11-532N4.2_ENST00000587106.1_RNA|TRDN_ENST00000398178.3_Intron|RP11-532N4.2_ENST00000427828.1_RNA|RP11-532N4.2_ENST00000434768.1_RNA|RP11-532N4.2_ENST00000589182.1_RNA|RP11-532N4.2_ENST00000418467.2_RNA	NM_001256020.1	NP_001242949.1	Q13061	TRDN_HUMAN	triadin	0					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		GATCTTTAAGAAAAAAAAAAG	0.388													2	4	---	---	---	---					
RP1-292B18.4	0	broad.mit.edu	37	6	151483584	151483584	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:151483584delA	ENST00000415477.1	-	0	66																											tcagctactcagggggctgag	0.527													2	4	---	---	---	---					
RP1-292B18.4	0	broad.mit.edu	37	6	151539150	151539152	+	RNA	DEL	TTG	TTG	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr6:151539150_151539152delTTG	ENST00000415477.1	-	0	66																											gggcctgggcttgttgttgttgt	0.512													5	2	---	---	---	---					
LOC102659288	102659288	broad.mit.edu	37	7	17482328	17482329	+	RNA	INS	-	-	A	rs36094444		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:17482328_17482329insA	ENST00000419463.1	+	0	189				AC019117.2_ENST00000439046.1_lincRNA																							GTAATGTTGACAAAAAAAAGCC	0.332													2	4	---	---	---	---					
LOC101927668	101927668	broad.mit.edu	37	7	19996325	19996326	+	RNA	INS	-	-	TCT	rs150029483	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:19996325_19996326insTCT	ENST00000449573.1	-	0	535																											cctgctccccctctgccttttg	0.530													3	3	---	---	---	---					
LOC101927668	101927668	broad.mit.edu	37	7	20146018	20146020	+	RNA	DEL	TTC	TTC	-	rs74274199		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:20146018_20146020delTTC	ENST00000590912.1	+	0	252																											TCTCAACTCTTTCTTCTTCTTAC	0.305													2	4	---	---	---	---					
LOC101927668	101927668	broad.mit.edu	37	7	20156227	20156228	+	RNA	INS	-	-	A	rs113537453		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:20156227_20156228insA	ENST00000590912.1	+	0	372																											agactctgtttaaaaaaaaaaa	0.396													2	4	---	---	---	---					
LINC01162	104355138	broad.mit.edu	37	7	20992943	20992943	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:20992943delT	ENST00000447262.2	+	0	151																											TAGCCTAGCATTTTTTTTTCT	0.348													3	6	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34450526	34450526	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:34450526delT	ENST00000419766.1	-	0	404					NR_033664.1|NR_033665.1																						gtggcacatatttgtagtctc	0.398													2	4	---	---	---	---					
RP11-806J6.1	0	broad.mit.edu	37	7	54001371	54001372	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:54001371_54001372insA	ENST00000418679.1	-	0	94																											aggctgtggagaaaaaggaagg	0.376													2	4	---	---	---	---					
LOC100996654	100996654	broad.mit.edu	37	7	54848495	54848495	+	RNA	DEL	A	A	-	rs75732784		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:54848495delA	ENST00000439413.2	+	0	100																											TACACAAAGCAAAAAAAAAAA	0.408													2	4	---	---	---	---					
LOC101927497	101927497	broad.mit.edu	37	7	92525016	92525017	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:92525016_92525017insT	ENST00000419668.1	+	0	189				AC002454.1_ENST00000452050.1_RNA|AC002454.1_ENST00000435695.1_RNA|AC002454.1_ENST00000424523.1_RNA																							ttttgaaggggttttttttttt	0.347													3	4	---	---	---	---					
AC003092.2	0	broad.mit.edu	37	7	93702556	93702559	+	RNA	DEL	GATA	GATA	-	rs71887670		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:93702556_93702559delGATA	ENST00000411946.1	-	0	163																											tagattagatgatagatagataga	0.328													2	4	---	---	---	---					
DLX6-AS1	285987	broad.mit.edu	37	7	96603957	96603958	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:96603957_96603958insA	ENST00000430027.2	-	0	1386				DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000605417.1_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000431497.2_RNA	NR_015448.1																						ctgttttgcagaaaaaaaaatg	0.342													2	4	---	---	---	---					
LINC01004	100216546	broad.mit.edu	37	7	104637287	104637288	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:104637287_104637288insT	ENST00000445184.1	-	0	93				RP11-325F22.3_ENST00000450686.1_RNA																							TTTGTATCCCAttttttttttt	0.426													2	4	---	---	---	---					
RP11-807H17.1	0	broad.mit.edu	37	7	125077838	125077839	+	RNA	INS	-	-	GTGT	rs34866375	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:125077838_125077839insGTGT	ENST00000453278.1	+	0	247																											GTGATAGTTTCgtgtgtgtgtg	0.460													2	4	---	---	---	---					
LINC-PINT	378805	broad.mit.edu	37	7	130579247	130579247	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr7:130579247delG	ENST00000432045.1	-	0	403				AC016831.7_ENST00000447430.1_RNA	NR_034120.1																						GCACCTTGAAGTGAGGCATTA	0.517													2	4	---	---	---	---					
ERICH1-AS1	619343	broad.mit.edu	37	8	1037553	1037554	+	RNA	INS	-	-	T	rs143186502		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:1037553_1037554insT	ENST00000522092.1	+	0	332				ERICH1-AS1_ENST00000578889.1_RNA	NR_073397.1|NR_073466.1																						ctctctctctcttttttttttt	0.386													3	4	---	---	---	---					
RP11-13N12.2	0	broad.mit.edu	37	8	16520067	16520068	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:16520067_16520068insA	ENST00000521055.1	+	0	401																											Ttcaccatcccaaaaaggctgt	0.371													2	4	---	---	---	---					
RP11-566H8.3	0	broad.mit.edu	37	8	31144480	31144480	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:31144480delT	ENST00000524022.1	+	0	213																											actgacCTGCTTTTTAATCTA	0.383													2	4	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36434771	36434771	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:36434771delC	ENST00000524132.1	-	0	484																											gcaaatctggccatcctgaaa	0.433													2	4	---	---	---	---					
RP11-388G22.1	0	broad.mit.edu	37	8	58606670	58606670	+	RNA	DEL	G	G	-	rs60732092		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:58606670delG	ENST00000520426.1	-	0	273																											TACAAAAAAagagagagagag	0.373													2	4	---	---	---	---					
RP11-6I2.3	0	broad.mit.edu	37	8	74996094	74996094	+	RNA	DEL	T	T	-	rs113368652		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:74996094delT	ENST00000519323.1	+	0	303																											gcctggctaattttttttttt	0.527													2	4	---	---	---	---					
RP11-354A14.1	0	broad.mit.edu	37	8	82827709	82827709	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:82827709delA	ENST00000534675.1	+	0	64																											ctcctgacataaaaaaaaaaa	0.428													2	4	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94439202	94439202	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:94439202delT	ENST00000501400.1	-	0	1133					NR_033858.1																						CCCCAGCCAATTCTATTCTAA	0.428													2	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96579657	96579658	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:96579657_96579658insC	ENST00000521905.1	+	0	281																											gaccaacatctccccagtctct	0.337													2	4	---	---	---	---					
RP11-1084E5.1	0	broad.mit.edu	37	8	110007118	110007118	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:110007118delT	ENST00000522244.1	-	0	264																											AATCTTGTACTTATAAAGTGA	0.363													2	4	---	---	---	---					
RP11-398G24.2	0	broad.mit.edu	37	8	123031335	123031336	+	RNA	INS	-	-	T	rs35174942		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:123031335_123031336insT	ENST00000523792.1	-	0	160																											AAGAATAGAGAttttttttttt	0.446													5	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130604292	130604293	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:130604292_130604293insC	ENST00000446592.3	-	0	312																											CAATGGTCACACCCCCCCCAGC	0.530													2	4	---	---	---	---					
LOC101927822	101927822	broad.mit.edu	37	8	134903550	134903550	+	RNA	DEL	T	T	-	rs56889162		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:134903550delT	ENST00000520149.2	+	0	45																											tctttctttctttctttcgac	0.443													3	3	---	---	---	---					
LOC401478	401478	broad.mit.edu	37	8	139067065	139067066	+	RNA	INS	-	-	AT			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:139067065_139067066insAT	ENST00000518973.1	-	0	514																											cacatgcacacatgtttatcgc	0.391													3	4	---	---	---	---					
RP11-706C16.8	0	broad.mit.edu	37	8	143891995	143891996	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr8:143891995_143891996insA	ENST00000510610.2	+	0	216																											tctctccacccccccctctttt	0.559													2	4	---	---	---	---					
LINC01239	441389	broad.mit.edu	37	9	22792759	22792760	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:22792759_22792760insA	ENST00000436786.1	+	0	524					NR_038977.1																						AAGAAAACTGCAAAAAAACAAC	0.411													2	4	---	---	---	---					
RP11-791O21.5	0	broad.mit.edu	37	9	91589772	91589773	+	RNA	DEL	GT	GT	-	rs79362152	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:91589772_91589773delGT	ENST00000421482.1	+	0	208																											gtgcgcgcgcgtgtgtgtgtgt	0.629													3	3	---	---	---	---					
LINC01508	101927873	broad.mit.edu	37	9	93158207	93158208	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:93158207_93158208insC	ENST00000425666.1	-	0	59																											TGCTTCACCTTCCCCCGTCTTG	0.564													2	4	---	---	---	---					
LINC01508	101927873	broad.mit.edu	37	9	93172701	93172701	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:93172701delA	ENST00000425666.1	-	0	59																											acaaaatgccaaaaattggga	0.308													2	4	---	---	---	---					
LINC01501	340515	broad.mit.edu	37	9	93245760	93245761	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr9:93245760_93245761insC	ENST00000449990.1	-	0	647					NR_034157.1																						tgcccaccagaccccactttct	0.495													2	4	---	---	---	---					
LINC00701	399708	broad.mit.edu	37	10	2350846	2350847	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:2350846_2350847insA	ENST00000418295.1	-	0	46					NR_038884.1																						ctgcatcccagaaaaaaggtct	0.361													2	4	---	---	---	---					
RP11-508N22.9	0	broad.mit.edu	37	10	38454833	38454834	+	RNA	INS	-	-	GTGT	rs138441945	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:38454833_38454834insGTGT	ENST00000419779.1	+	0	225																											CACTTTGCGGGgtgtgtgtgtg	0.465													3	4	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125132205	125132206	+	RNA	DEL	TG	TG	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr10:125132205_125132206delTG	ENST00000448347.1	+	0	586																											tgcacgtgcatgtgtgtgtgtg	0.480													3	6	---	---	---	---					
DNHD1	144132	broad.mit.edu	37	11	6567895	6567896	+	In_Frame_Ins	INS	-	-	TGCCCTACTGCA	rs35685553	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:6567895_6567896insTGCCCTACTGCA	ENST00000254579.6	+	21	6290_6291	c.5726_5727insTGCCCTACTGCA	c.(5725-5727)ggc>gTGCCCTACTGCAgc	p.1909_1909G>VPYCS	DNHD1_ENST00000527990.2_In_Frame_Ins_p.1909_1909G>VPYCS	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	1909				A -> AALLH (in Ref. 5; BAB85004 and 6; CAB70845).	microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ATTGAGGAGGCTGCCCTACTGC	0.559													3	3	---	---	---	---					
RP11-587D21.4	0	broad.mit.edu	37	11	27825828	27825829	+	RNA	DEL	CA	CA	-	rs5790667		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:27825828_27825829delCA	ENST00000530663.1	-	0	147																											cacacacgcgcacacacacaca	0.421													3	5	---	---	---	---					
RP11-460B17.3	0	broad.mit.edu	37	11	29432836	29432837	+	RNA	INS	-	-	TG	rs143088981	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:29432836_29432837insTG	ENST00000525097.1	-	0	153																											catcctagttttgtgtgtgtgt	0.342													2	4	---	---	---	---					
OR4C15	81309	broad.mit.edu	37	11	55322055	55322056	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:55322055_55322056insG	ENST00000314644.2	+	1	273_274	c.273_274insG	c.(271-276)gtggggfs	p.VG91fs		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TTGCAACTGTTGGGGGCAACAT	0.431										HNSCC(20;0.049)			8	608	---	---	---	---					
OR5D16	390144	broad.mit.edu	37	11	55606403	55606403	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:55606403delC	ENST00000378396.1	+	1	176	c.176delC	c.(175-177)acfs	p.T59fs		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				AAATTGCATACCCCCATGTAT	0.428													12	272	---	---	---	---					
SLC22A24	283238	broad.mit.edu	37	11	62911085	62911085	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:62911085delT	ENST00000417740.1	-	1	608	c.167delA	c.(166-168)atfs	p.N56fs	SLC22A10_ENST00000525620.1_Intron|SLC22A24_ENST00000326192.5_Frame_Shift_Del_p.N56fs	NM_001136506.2	NP_001129978.2			solute carrier family 22, member 24											kidney(1)|stomach(1)	2						CACAGTGTCATTGTCCAGGAG	0.507													18	29	---	---	---	---					
RP11-262A12.1	0	broad.mit.edu	37	11	109664846	109664846	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:109664846delA	ENST00000534252.2	-	0	393																											atgctataacaaaatacctta	0.333													2	4	---	---	---	---					
LOC100507283	100507283	broad.mit.edu	37	11	124688413	124688413	+	RNA	DEL	T	T	-	rs73012460		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:124688413delT	ENST00000499143.2	+	0	1284																											tctgccttccttttttttttt	0.463													2	4	---	---	---	---					
LOC100507431	100507431	broad.mit.edu	37	11	130730716	130730717	+	RNA	INS	-	-	AGGCCCC	rs66463260	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr11:130730716_130730717insAGGCCCC	ENST00000533812.2	-	0	946																											TAAACCCTGCTAGagaggtgcg	0.530													2	4	---	---	---	---					
LOC283440	283440	broad.mit.edu	37	12	2877580	2877580	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:2877580delC	ENST00000536497.1	-	0	147				RP11-885B4.1_ENST00000540093.1_lincRNA	NR_033958.1																						gtgaacccctcgaagccaggT	0.557													4	7	---	---	---	---					
LOC101928100	101928100	broad.mit.edu	37	12	10522527	10522528	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:10522527_10522528insA	ENST00000500682.1	+	0	265																											aagatagaaagaaaaaaaaact	0.441													2	4	---	---	---	---					
RP11-114G22.1	0	broad.mit.edu	37	12	23171340	23171340	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:23171340delA	ENST00000540895.1	+	0	508																											GATTGGGGGGAGACCTTTTCA	0.388													2	4	---	---	---	---					
RP11-547C5.2	0	broad.mit.edu	37	12	43390126	43390127	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:43390126_43390127insT	ENST00000551279.1	-	0	162_163																											AGACttttttctttttttttga	0.475													3	4	---	---	---	---					
RP11-415I12.3	0	broad.mit.edu	37	12	64166995	64167006	+	RNA	DEL	AAGAAAGAAAGA	AAGAAAGAAAGA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:64166995_64167006delAAGAAAGAAAGA	ENST00000509615.2	-	0	238																											agaaagaaagaagaaagaaagaaagaaagaaa	0.344													3	4	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76191286	76191287	+	RNA	INS	-	-	TT	rs71686279		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:76191286_76191287insTT	ENST00000552856.1	-	0	295																											gggagacaggcttttttttttt	0.460													4	2	---	---	---	---					
LINC01234	100506465	broad.mit.edu	37	12	114189886	114189886	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:114189886delA	ENST00000547963.1	-	0	69																											gtgttcatttAAAAAAAAAAG	0.408													2	4	---	---	---	---					
RP11-897M7.1	0	broad.mit.edu	37	12	131962110	131962111	+	RNA	INS	-	-	ATA	rs141746341		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr12:131962110_131962111insATA	ENST00000535133.1	-	0	195																											tggtaatggtggtgatgatggt	0.396													4	6	---	---	---	---					
LINC00572	100861573	broad.mit.edu	37	13	30497371	30497372	+	RNA	INS	-	-	AG	rs67186814	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr13:30497371_30497372insAG	ENST00000450264.1	-	0	149																											GTGATCTCTGAAGAGAGAGAGA	0.416													3	4	---	---	---	---					
LINC00348	100885781	broad.mit.edu	37	13	71698310	71698310	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr13:71698310delA	ENST00000428761.1	+	0	108					NR_047699.1																						tggggagtctactggtatctc	0.458													2	4	---	---	---	---					
SUPT16H	11198	broad.mit.edu	37	14	21820849	21820850	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:21820849_21820850insG	ENST00000216297.2	-	26	3464_3465	c.3126_3127insC	c.(3124-3129)ccagaafs	p.E1043fs		NM_007192.3	NP_009123.1	Q9Y5B9	SP16H_HUMAN	suppressor of Ty 16 homolog (S. cerevisiae)	1043					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CTCTTTTTCTTGGGGGGTGCAG	0.480													8	346	---	---	---	---					
LOC101929735	101929735	broad.mit.edu	37	14	22861230	22861230	+	RNA	DEL	T	T	-	rs34663063		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:22861230delT	ENST00000514473.2	-	0	225				AE000661.37_ENST00000541008.1_RNA|AE000661.37_ENST00000535351.1_RNA|AE000661.37_ENST00000545670.1_RNA																							GTATCCGTGATGTCCCCAAGT	0.468													6	0	---	---	---	---					
RP11-314P15.2	0	broad.mit.edu	37	14	26308198	26308199	+	RNA	INS	-	-	ATC	rs142385273	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:26308198_26308199insATC	ENST00000546412.1	-	0	258																											TGCTGTTTTAGATCACTGTCTT	0.381													5	3	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	42832652	42832653	+	RNA	INS	-	-	AATTGTG	rs137988184	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:42832652_42832653insAATTGTG	ENST00000557251.1	+	0	18																											ATAGTGAGTGAAATTGTGGTGG	0.302													3	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44790784	44790784	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:44790784delT	ENST00000553827.1	-	0	69																											cacctggccATTTTTTAAACa	0.488													2	4	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46614589	46614589	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:46614589delG	ENST00000556886.1	+	0	58					NR_102701.1																						TGGCAAgagtgggaaagtagt	0.363													2	4	---	---	---	---					
YLPM1	56252	broad.mit.edu	37	14	75248518	75248519	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:75248518_75248519insC	ENST00000325680.7	+	4	1896_1897	c.1772_1773insC	c.(1771-1773)cccfs	p.P591fs	YLPM1_ENST00000238571.3_Intron|YLPM1_ENST00000552421.1_Frame_Shift_Ins_p.P591fs	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	392					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		CCACCAGTTCTCCCCCCACCTT	0.599													10	338	---	---	---	---					
RP11-7F17.4	0	broad.mit.edu	37	14	77545623	77545624	+	RNA	INS	-	-	TTTTC	rs142698524		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:77545623_77545624insTTTTC	ENST00000554043.1	-	0	219																											cacaGtcttttttttcttttct	0.426													3	6	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82331480	82331481	+	RNA	INS	-	-	A	rs146914421		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr14:82331480_82331481insA	ENST00000554814.1	+	0	315																											AAGAATCTGTCAAAAAAAAAAA	0.312													6	1	---	---	---	---					
PWRN1	791114	broad.mit.edu	37	15	24824884	24824885	+	RNA	INS	-	-	T	rs141969475	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:24824884_24824885insT	ENST00000568609.1	+	0	1126					NR_026646.1																						AAAGCTTTGTCTTTTTGCAGTA	0.366													3	3	---	---	---	---					
LOC100128714	100128714	broad.mit.edu	37	15	26183184	26183185	+	RNA	INS	-	-	C	rs139736945	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:26183184_26183185insC	ENST00000383019.2	+	0	207					NR_040082.1																						accatttttctcccccccaaag	0.391													2	4	---	---	---	---					
LOC100128714	100128714	broad.mit.edu	37	15	26198073	26198073	+	RNA	DEL	A	A	-	rs111644740		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:26198073delA	ENST00000383019.2	+	0	207					NR_040082.1																						cttgttacataattctggttt	0.343													3	6	---	---	---	---					
GABRB3	2562	broad.mit.edu	37	15	26866529	26866530	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:26866529_26866530insA	ENST00000541819.2	-	5	662_663	c.560_561insT	c.(559-561)gcafs	p.A187fs	GABRB3_ENST00000299267.4_Frame_Shift_Ins_p.A131fs|GABRB3_ENST00000400188.3_Frame_Shift_Ins_p.A60fs|GABRB3_ENST00000311550.5_Frame_Shift_Ins_p.A131fs|GABRB3_ENST00000545868.1_Frame_Shift_Ins_p.A46fs			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	131					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TCACTCCATGCACAAATGACTT	0.495													21	122	---	---	---	---					
HERC2P9	440248	broad.mit.edu	37	15	28900331	28900331	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:28900331delA	ENST00000528584.1	+	0	14					NR_036443.1																						actctgtctcaaaaaaaaaaa	0.413													4	7	---	---	---	---					
RP11-122D10.1	0	broad.mit.edu	37	15	37170937	37170940	+	RNA	DEL	TGTG	TGTG	-	rs34628308		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:37170937_37170940delTGTG	ENST00000558089.1	-	0	488																											CAtgcgtgtttgtgtgtgtgtgtg	0.495													3	5	---	---	---	---					
RP11-346D14.1	0	broad.mit.edu	37	15	38451367	38451368	+	RNA	DEL	CT	CT	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:38451367_38451368delCT	ENST00000561320.1	-	0	222																											TGTctttctcctctctctctct	0.455													2	4	---	---	---	---					
RP11-624L4.1	0	broad.mit.edu	37	15	39626677	39626678	+	RNA	INS	-	-	T	rs35224151		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:39626677_39626678insT	ENST00000559318.1	-	0	408				RP11-624L4.1_ENST00000560484.1_RNA|RP11-624L4.1_ENST00000558209.1_RNA																							GCAAGATTGAAttttttttttt	0.465													4	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48182359	48182359	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:48182359delA	ENST00000560900.1	+	0	195																											CCCAGAATGGAATATGTCAAA	0.348													2	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48269888	48269889	+	RNA	INS	-	-	T	rs147211516	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:48269888_48269889insT	ENST00000560900.1	+	0	195																											tttctttttcatttttttttgt	0.282													2	4	---	---	---	---					
CTD-2184D3.5	0	broad.mit.edu	37	15	52364731	52364732	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:52364731_52364732insT	ENST00000558607.1	-	0	54																											ACCAACTTGTCttttttttgag	0.470													2	4	---	---	---	---					
ANKRD34C-AS1	729911	broad.mit.edu	37	15	79570288	79570291	+	RNA	DEL	CCTT	CCTT	-	rs59775108		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:79570288_79570291delCCTT	ENST00000560533.1	-	0	207																											CTGACCCCTCccttccttccttcc	0.397													3	6	---	---	---	---					
CTD-2034I4.1	0	broad.mit.edu	37	15	81750914	81750915	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:81750914_81750915insT	ENST00000559211.1	+	0	98																											ccacctctgagttttttttttt	0.317													2	4	---	---	---	---					
CTD-2034I4.1	0	broad.mit.edu	37	15	81850739	81850740	+	RNA	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:81850739_81850740insT	ENST00000559211.1	+	0	98																											attcttttttctttttttgtct	0.302													3	3	---	---	---	---					
RP11-382A20.4	0	broad.mit.edu	37	15	84033236	84033237	+	RNA	DEL	AC	AC	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:84033236_84033237delAC	ENST00000565495.1	+	0	264																											GCTATCAGCTacacacacacac	0.426													3	6	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	87987190	87987190	+	RNA	DEL	A	A	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:87987190delA	ENST00000560439.1	-	0	278																											TGCTTGTCATAAGAACAGTAG	0.393													2	4	---	---	---	---					
CTD-2544M6.1	0	broad.mit.edu	37	15	98646954	98646955	+	RNA	INS	-	-	G	rs139488428	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr15:98646954_98646955insG	ENST00000560360.1	-	0	291																											caccactacctggggcagcctg	0.470													2	4	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	80469	80470	+	RNA	DEL	AC	AC	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:80469_80470delAC	ENST00000568710.1	-	0	434																											acacagacatacacacacacac	0.465													5	1	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5467161	5467161	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:5467161delT	ENST00000569895.1	+	0	304																											TTAAGCAGCCTTTTGTGAACT	0.393													2	4	---	---	---	---					
CD2BP2	10421	broad.mit.edu	37	16	30365345	30365346	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:30365345_30365346insC	ENST00000305596.3	-	4	426_427	c.251_252insG	c.(250-252)ggtfs	p.G84fs	CD2BP2_ENST00000569466.1_Frame_Shift_Ins_p.G84fs	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	84					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						TGATCCGAACACCCCCCTCGCT	0.579													7	190	---	---	---	---					
RP11-67H24.2	0	broad.mit.edu	37	16	32828380	32828381	+	RNA	INS	-	-	T	rs148268914	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:32828380_32828381insT	ENST00000569859.1	+	0	373																											agcatctgtggtttgttaggtc	0.337													3	6	---	---	---	---					
LOC101927132	101927132	broad.mit.edu	37	16	47914821	47914822	+	RNA	INS	-	-	TCA	rs35484814	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:47914821_47914822insTCA	ENST00000569726.1	+	0	1830				AC140542.2_ENST00000570024.1_lincRNA																							aatcatcaaggtcatcatcatc	0.406													3	5	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58906650	58906650	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:58906650delC	ENST00000500117.1	+	0	679				RP11-700H13.1_ENST00000562304.1_lincRNA																							gctttgctttccgcagtggct	0.378													2	4	---	---	---	---					
LOC102724467	102724467	broad.mit.edu	37	16	87810798	87810799	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:87810798_87810799insC	ENST00000563993.1	-	0	521																											TCTGTGTGGGGCCCCCCAAAAC	0.540													2	4	---	---	---	---					
ZNF276	92822	broad.mit.edu	37	16	89804205	89804214	+	Splice_Site	DEL	CCCTCTCAGA	CCCTCTCAGA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr16:89804205_89804214delCCCTCTCAGA	ENST00000289816.5	+	10	1561_1562	c.1249_splice	c.e10-1	p.417_splice	FANCA_ENST00000389301.3_3'UTR|ZNF276_ENST00000568064.1_Splice_Site_p.400_splice|ZNF276_ENST00000446326.2_Splice_Site_p.278_splice|ZNF276_ENST00000443381.2_Splice_Site_p.492_splice	NM_152287.3	NP_689500.2	Q8N554	ZN276_HUMAN	zinc finger protein 276	492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(6)|prostate(1)	14		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTGGACTCTCCCCTCTCAGAGGTGCGGAAC	0.552													10	30	---	---	---	---					
RP11-64J4.2	0	broad.mit.edu	37	17	3238331	3238332	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:3238331_3238332insA	ENST00000573491.1	-	0	359																											atttgagaggcaaaagtataac	0.327													2	4	---	---	---	---					
MYH8	4626	broad.mit.edu	37	17	10303998	10304000	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:10303998_10304000delCTC	ENST00000403437.2	-	27	3536_3538	c.3442_3444delGAG	c.(3442-3444)del	p.E1148del	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1148					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCTCGCTGATCTCCTCCAGTTCC	0.611									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				53	76	---	---	---	---					
RP11-173M1.4	0	broad.mit.edu	37	17	25669995	25669996	+	RNA	DEL	CT	CT	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:25669995_25669996delCT	ENST00000581118.1	+	0	172																											ccctccctccctctctctctct	0.480													2	4	---	---	---	---					
CRLF3	51379	broad.mit.edu	37	17	29151659	29151660	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:29151659_29151660insC	ENST00000324238.6	-	1	134_135	c.10_11insG	c.(10-12)gatfs	p.D4fs	CRLF3_ENST00000544695.1_5'UTR	NM_015986.3	NP_057070.3	Q8IUI8	CRLF3_HUMAN	cytokine receptor-like factor 3	4					negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|positive regulation of cell cycle arrest|positive regulation of JAK-STAT cascade|positive regulation of transcription from RNA polymerase II promoter	cytoplasm		p.A4T(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17		all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				CAGCTCCATCGCCCCCCTCATC	0.738													3	6	---	---	---	---					
RP11-271K11.5	0	broad.mit.edu	37	17	29369646	29369647	+	RNA	DEL	CA	CA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:29369646_29369647delCA	ENST00000583112.1	-	0	628																		p.?(1)									cacatgcaagcacacacacaca	0.500													2	4	---	---	---	---					
CCL14	6358	broad.mit.edu	37	17	34313577	34313578	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr17:34313577_34313578insT	ENST00000591669.1	+	2	149_150	c.23_24insT	c.(22-24)gtgfs	p.V8fs	CCL15-CCL14_ENST00000481427.2_Intron|CCL14_ENST00000536149.1_Intron|CTB-186H2.3_ENST00000593057.1_Intron|CCL14_ENST00000586216.1_Intron|CCL14_ENST00000394509.4_Intron|CCL14_ENST00000435911.2_Intron|CCL14_ENST00000480944.2_5'UTR																							CAGGCTCTAGGTTGGAAGGAAG	0.545													14	47	---	---	---	---					
RP11-161I6.2	0	broad.mit.edu	37	18	2105082	2105083	+	RNA	INS	-	-	C	rs141614868		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:2105082_2105083insC	ENST00000579097.1	-	0	310																											GCTTCGCTTCTCCCCCCCAACT	0.564											OREG0024837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	6	---	---	---	---					
TGIF1	7050	broad.mit.edu	37	18	3452223	3452223	+	Frame_Shift_Del	DEL	T	T	-	rs11571510		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:3452223delT	ENST00000330513.5	+	1	549	c.246delT	c.(244-246)ccfs	p.P85fs	TGIF1_ENST00000577543.1_Intron|TGIF1_ENST00000401449.1_Intron|TGIF1_ENST00000551541.1_Intron|TGIF1_ENST00000551402.1_Intron|TGIF1_ENST00000548489.2_Intron|TGIF1_ENST00000345133.5_Intron|TGIF1_ENST00000407501.2_Intron|TGIF1_ENST00000405385.3_Intron|TGIF1_ENST00000343820.5_Intron	NM_170695.2	NP_733796.2	Q15583	TGIF1_HUMAN	TGFB-induced factor homeobox 1	85					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity	p.P83fs*51(1)		cervix(1)|endometrium(3)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13	Esophageal squamous(4;0.0859)	Colorectal(8;0.0104)				GCGCCCCCCCTCCTCCACCGG	0.766													6	6	---	---	---	---					
RP11-784B15.1	0	broad.mit.edu	37	18	27117056	27117056	+	RNA	DEL	T	T	-	rs61425001		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:27117056delT	ENST00000584482.1	+	0	446																											gctaatgtacttttttttttt	0.493													4	2	---	---	---	---					
RP11-879F14.1	0	broad.mit.edu	37	18	59282694	59282695	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:59282694_59282695insC	ENST00000590968.1	-	0	317																											tgccaccaccaccccccagcca	0.436													2	4	---	---	---	---					
LOC643542	643542	broad.mit.edu	37	18	65208025	65208026	+	RNA	DEL	TG	TG	-	rs34427027		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:65208025_65208026delTG	ENST00000583687.1	+	0	204					NR_033921.1																						ATCATGTGCCtgtgtgtgtgtg	0.406													4	4	---	---	---	---					
LOC100505817	100505817	broad.mit.edu	37	18	70992376	70992377	+	RNA	INS	-	-	TCAG	rs35504761	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr18:70992376_70992377insTCAG	ENST00000563172.1	+	0	201_202					NR_038340.1																						cacctatgacctcaggtcctca	0.505													7	0	---	---	---	---					
TECR	9524	broad.mit.edu	37	19	14674910	14674911	+	Splice_Site	INS	-	-	T			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:14674910_14674911insT	ENST00000600083.1	+	6	551		c.e6+1		TECR_ENST00000215567.5_Splice_Site|TECR_ENST00000596073.1_Splice_Site|TECR_ENST00000436007.2_Splice_Site			Q9NZ01	TECR_HUMAN	trans-2,3-enoyl-CoA reductase						fatty acid elongation|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	trans-2-enoyl-CoA reductase (NADPH) activity|very long-chain-acyl-CoA dehydrogenase activity			endometrium(1)|large_intestine(1)|ovary(1)	3						CAGTGGTGCAGTAAGTGGGGCA	0.599													21	49	---	---	---	---					
AC011523.2	0	broad.mit.edu	37	19	51342839	51342875	+	RNA	DEL	GGAGGAGGGGCTGGGGTCCTGGACTCCTGGGTCTGAA	GGAGGAGGGGCTGGGGTCCTGGACTCCTGGGTCTGAA	-	rs2739445	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:51342839_51342875delGGAGGAGGGGCTGGGGTCCTGGACTCCTGGGTCTGAA	ENST00000598079.1	+	0	213																											tgggtctgagggaggaggggctggggtcctggactcctgggtctgaaggaggagggg	0.641													7	3	---	---	---	---					
ZSCAN1	284312	broad.mit.edu	37	19	58565207	58565207	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr19:58565207delG	ENST00000282326.1	+	6	1262	c.1015delG	c.(1015-1017)gcfs	p.G339fs		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	339					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CACTGAGCATGGCAAGATCCA	0.657													16	23	---	---	---	---					
RP5-1031J8.1	0	broad.mit.edu	37	20	38426662	38426663	+	RNA	INS	-	-	C			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr20:38426662_38426663insC	ENST00000444436.1	+	0	211																											gactgctctgacccccccaccc	0.475													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11045627	11045627	+	RNA	DEL	A	A	-	rs56675609		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:11045627delA	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CCAAAATAAGATGTGAAAAGA	0.363													8	13	---	---	---	---					
AP000282.2	0	broad.mit.edu	37	21	34287100	34287101	+	RNA	INS	-	-	A			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:34287100_34287101insA	ENST00000454622.1	-	0	201				AP000282.2_ENST00000420356.1_RNA																							TGACCATGCTGAAAAAAAAGAT	0.411													2	4	---	---	---	---					
AP000282.2	0	broad.mit.edu	37	21	34320153	34320153	+	RNA	DEL	T	T	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr21:34320153delT	ENST00000454622.1	-	0	201				AP000282.2_ENST00000420356.1_RNA																							gactgacttcttacacgtagc	0.358													2	4	---	---	---	---					
LOC102724900	102724900	broad.mit.edu	37	22	27762038	27762039	+	RNA	INS	-	-	G			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:27762038_27762039insG	ENST00000413244.1	+	0	491																											gctccagttttgggggcagtgg	0.421													2	4	---	---	---	---					
RP3-438O4.4	0	broad.mit.edu	37	22	30601541	30601541	+	RNA	DEL	G	G	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:30601541delG	ENST00000432360.1	-	0	62																											GCACAGAGCTGGGGAAAAATC	0.592													2	4	---	---	---	---					
RP1-149A16.12	0	broad.mit.edu	37	22	32728405	32728406	+	RNA	INS	-	-	C	rs137888968	by1000genomes	TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:32728405_32728406insC	ENST00000446543.1	-	0	94																											acttcccacttcctcccctggt	0.579													4	2	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35429040	35429041	+	RNA	DEL	AC	AC	-	rs56228166		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:35429040_35429041delAC	ENST00000448318.4	-	0	686																											gtcgcccactacacacacacac	0.406													2	4	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35435235	35435239	+	RNA	DEL	TTTTT	TTTTT	-	rs76415449		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:35435235_35435239delTTTTT	ENST00000448318.4	-	0	686																											CATATTCCTCttttttttttttttt	0.507													2	4	---	---	---	---					
LOC284930	284930	broad.mit.edu	37	22	48050357	48050357	+	RNA	DEL	T	T	-	rs11306064		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chr22:48050357delT	ENST00000423737.1	+	0	387																											atggtggtgatgggtaatggt	0.413													6	1	---	---	---	---					
RP6-1O2.1	0	broad.mit.edu	37	X	10327528	10327529	+	RNA	DEL	GT	GT	-	rs3049021		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:10327528_10327529delGT	ENST00000454113.1	+	0	553																											CTAGCCCAGCgtgtgtgtgtgt	0.406													3	6	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22421515	22421515	+	RNA	DEL	T	T	-	rs58908497		TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:22421515delT	ENST00000455399.1	-	0	312																											GTGTCCACAGttttttttttt	0.483													2	4	---	---	---	---					
HDX	139324	broad.mit.edu	37	X	83723979	83723979	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:83723979delC	ENST00000297977.5	-	3	863	c.752delG	c.(751-753)aafs	p.R251fs	HDX_ENST00000373177.2_Frame_Shift_Del_p.R251fs|HDX_ENST00000506585.2_Frame_Shift_Del_p.R193fs	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	251						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GTAAGGGTCTCTAATAGTTGG	0.438													9	138	---	---	---	---					
FIRRE	286467	broad.mit.edu	37	X	130950840	130950840	+	RNA	DEL	C	C	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:130950840delC	ENST00000427391.1	-	0	496					NR_026975.1																						GTCCCAACTTCCCCACAGGTG	0.478											OREG0019933	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
SPANXA2-OT1	619455	broad.mit.edu	37	X	140596112	140596113	+	RNA	DEL	TA	TA	-			TCGA-17-Z001-01A-01W-0746-08	TCGA-17-Z001-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d5e77555-9412-4e64-a6aa-65c996e3d521	7d924dfd-11ca-4f47-b095-13685722d7ef	g.chrX:140596112_140596113delTA	ENST00000421554.1	+	0	406					NR_037183.1																						tgtgtatgtctatatatatatg	0.371													2	4	---	---	---	---