Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LEPRE1	64175	broad.mit.edu	37	1	43213468	43213468	+	Splice_Site	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:43213468C>T	ENST00000236040.4	-	13	1880	c.1838_splice	c.e13-1	p.A614_splice	LEPRE1_ENST00000462474.1_5'UTR|LEPRE1_ENST00000397054.3_Splice_Site_p.A614_splice|LEPRE1_ENST00000296388.5_Splice_Site_p.A614_splice	NM_001243246.1	NP_001230175.1	Q32P28	P3H1_HUMAN	leucine proline-enriched proteoglycan (leprecan) 1	614	Fe2OG dioxygenase.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			large_intestine(2)|lung(15)|ovary(5)|prostate(1)|urinary_tract(3)	26	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TAAAGGATGGCGCTGGGAAAG	0.557000													12	36					0	0	0.080935	0	0
LTBP1	4052	broad.mit.edu	37	2	33500077	33500077	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:33500077G>A	ENST00000404816.2	+	17	3142	c.2789G>A	c.(2788-2790)cGc>cAc	p.R930H	LTBP1_ENST00000418533.2_Missense_Mutation_p.R604H|LTBP1_ENST00000404525.1_Missense_Mutation_p.R551H|LTBP1_ENST00000354476.3_Missense_Mutation_p.R931H|LTBP1_ENST00000407925.1_Missense_Mutation_p.R604H|LTBP1_ENST00000390003.4_Missense_Mutation_p.R605H|LTBP1_ENST00000402934.1_Missense_Mutation_p.R551H			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	930	EGF-like 5; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TCCCAGGGCCGCTGTGAAAAC	0.428000													30	40					0	0	0.037714	0	0
ATP8A2	51761	broad.mit.edu	37	13	26411405	26411405	+	Silent	SNP	C	C	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:26411405C>G	ENST00000381655.2	+	29	3001	c.2859C>G	c.(2857-2859)ggC>ggG	p.G953G	ATP8A2_ENST00000491840.1_3'UTR|ATP8A2_ENST00000255283.8_Silent_p.G888G	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	913					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		CCCAGAATGGCGAAGGCTTCA	0.493000													19	107					0	0	0.043863	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62645903	62645903	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:62645903G>T	ENST00000337910.5	-	7	1879	c.1542C>A	c.(1540-1542)ttC>ttA	p.F514L	RHOBTB1_ENST00000357917.4_Missense_Mutation_p.F514L	NM_001242359.1|NM_014836.4	NP_001229288.1|NP_055651.1	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	514	BTB 2.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	Prostate(12;0.0112)					ATGACCCCCCGAACATGGCTG	0.473000													6	144					5.4927e-09	6.64906e-09	0.047766	1	0
OGDH	4967	broad.mit.edu	37	7	44747321	44747321	+	Silent	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:44747321C>T	ENST00000222673.5	+	22	2979	c.2937C>T	c.(2935-2937)cgC>cgT	p.R979R	OGDH_ENST00000449767.1_Silent_p.R975R|OGDH_ENST00000447398.1_Silent_p.R990R|OGDH_ENST00000444676.1_Silent_p.R994R|OGDH_ENST00000439616.2_Silent_p.R829R|OGDH_ENST00000543843.1_Silent_p.R930R	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	979					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	CCATCAGCCGCGCCAAGCCCG	0.597000													6	42					0	0	0.069234	0	0
CCDC102B	79839	broad.mit.edu	37	18	66504396	66504396	+	Silent	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:66504396A>G	ENST00000360242.5	+	2	513	c.396A>G	c.(394-396)aaA>aaG	p.K132K	CCDC102B_ENST00000584156.1_Silent_p.K132K|CCDC102B_ENST00000358653.5_Silent_p.K132K|CCDC102B_ENST00000319445.6_Silent_p.K132K|CCDC102B_ENST00000577772.1_3'UTR	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	132										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				TGGCGATGAAAGAATTGAGTA	0.443000													3	86					0	0	0.004672	0	0
CCDC105	126402	broad.mit.edu	37	19	15132685	15132685	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:15132685A>G	ENST00000292574.3	+	6	1287	c.1205A>G	c.(1204-1206)cAg>cGg	p.Q402R		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	402					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CGCATGTACCAGAGACACGTG	0.632000													10	70					0	0	0.069234	0	0
TARBP1	6894	broad.mit.edu	37	1	234529569	234529569	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:234529569C>T	ENST00000040877.1	-	27	4257	c.4258G>A	c.(4258-4260)Gaa>Aaa	p.E1420K	TARBP1_ENST00000483404.1_5'UTR	NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	1420					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			TTATCTGCTTCGACCAAATTA	0.388000													4	35					0	0	0.009096	0	0
PPEF2	5470	broad.mit.edu	37	4	76793210	76793210	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:76793210G>A	ENST00000286719.7	-	13	1973	c.1617C>T	c.(1615-1617)aaC>aaT	p.N539N		NM_006239.2	NP_006230.2	O14830	PPE2_HUMAN	protein phosphatase, EF-hand calcium binding domain 2	539	Catalytic.				detection of stimulus involved in sensory perception|negative regulation of MAPKKK cascade|negative regulation of peptidyl-threonine phosphorylation|protein dephosphorylation|visual perception	cytoplasm|photoreceptor inner segment|photoreceptor outer segment	calcium ion binding|Hsp70 protein binding|Hsp90 protein binding|iron ion binding|manganese ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	50			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GGGTCACCTTGTTAGCTTGAT	0.428000													8	48					0	0	0.038147	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250075	140250075	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:140250075G>A	ENST00000398640.2	+	1	1387	c.1387G>A	c.(1387-1389)Gtg>Atg	p.V463M	PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCGTGTTCGTGAAGGAGAA	0.652000													21	61					0	0	0.076483	0	0
EFCAB13	124989	broad.mit.edu	37	17	45451930	45451930	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:45451930A>T	ENST00000331493.2	+	12	1381	c.970A>T	c.(970-972)Agt>Tgt	p.S324C	EFCAB13_ENST00000517484.1_Missense_Mutation_p.S228C	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		GAAGAAAAATAGTTTGTCTTC	0.299000													10	42					0	0	0.058154	0	0
FILIP1	27145	broad.mit.edu	37	6	76022205	76022205	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:76022205G>C	ENST00000393004.2	-	5	3564	c.3343C>G	c.(3343-3345)Cac>Gac	p.H1115D	FILIP1_ENST00000370020.1_Missense_Mutation_p.H1016D|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.H1115D			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1115								p.H1115Y(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GAGGAGAGGTGATTCCTGGGA	0.537000													9	142					0	0	0.058154	0	0
VCAN	1462	broad.mit.edu	37	5	82849190	82849190	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:82849190G>A	ENST00000265077.3	+	11	10066	c.9501G>A	c.(9499-9501)gaG>gaA	p.E3167E	VCAN_ENST00000513016.1_3'UTR|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000502527.2_Silent_p.E426E|VCAN_ENST00000342785.4_Silent_p.E1413E|VCAN-AS1_ENST00000513899.1_RNA|VCAN_ENST00000343200.5_Silent_p.E2180E|VCAN_ENST00000512590.2_Silent_p.E1365E	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	3167					cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGATACCGAGACATGTGACT	0.498000													19	65					0	0	0.050027	0	0
LYZL1	84569	broad.mit.edu	37	10	29580783	29580783	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:29580783G>A	ENST00000375500.3	+	2	182	c.125G>A	c.(124-126)cGg>cAg	p.R42Q		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	0					cell wall macromolecule catabolic process	extracellular region	lysozyme activity	p.R42Q(1)		central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				TTCTGTCTCCGGCAGGCTTTG	0.547000													11	14					0	0	0.033300	0	0
FSHR	2492	broad.mit.edu	37	2	49295412	49295412	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:49295412T>C	ENST00000406846.2	-	2	289	c.170A>G	c.(169-171)aAg>aGg	p.K57R	FSHR_ENST00000346173.3_Missense_Mutation_p.K57R|FSHR_ENST00000304421.4_Missense_Mutation_p.K57R	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	57					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GACTCGAAGCTTGGTGAGGAC	0.403000									Gonadal Dysgenesis, 46 XX				4	284					0	0	0.009096	0	0
KCNMA1	3778	broad.mit.edu	37	10	78729751	78729751	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:78729751T>A	ENST00000286627.5	-	19	3119	c.2167A>T	c.(2167-2169)Acc>Tcc	p.T723S	KCNMA1_ENST00000406533.3_Missense_Mutation_p.T785S|KCNMA1_ENST00000372440.1_Missense_Mutation_p.T723S|KCNMA1_ENST00000404857.1_Missense_Mutation_p.T723S|RP11-443A13.5_ENST00000598613.1_RNA|KCNMA1_ENST00000404771.3_Missense_Mutation_p.T781S|RP11-443A13.5_ENST00000458661.2_RNA|KCNMA1_ENST00000354353.5_Missense_Mutation_p.T784S|KCNMA1_ENST00000286628.8_Missense_Mutation_p.T781S|KCNMA1_ENST00000372443.1_Missense_Mutation_p.T723S|RP11-443A13.5_ENST00000600782.1_RNA	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	734					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TTAGGCGAGGTGTTGGGTGAG	0.547000													7	101					0	0	0.038147	0	0
USP44	84101	broad.mit.edu	37	12	95927783	95927783	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:95927783C>A	ENST00000258499.3	-	2	538	c.250G>T	c.(250-252)Gat>Tat	p.D84Y	USP44_ENST00000552440.1_Missense_Mutation_p.D84Y|USP44_ENST00000537435.2_Missense_Mutation_p.D84Y|USP44_ENST00000393091.2_Missense_Mutation_p.D84Y	NM_001278393.1|NM_032147.2	NP_001265322.1|NP_115523.2	Q9H0E7	UBP44_HUMAN	ubiquitin specific peptidase 44	84					anaphase|cell division|mitosis|negative regulation of mitotic anaphase-promoting complex activity|protein deubiquitination|regulation of spindle checkpoint|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(5)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	36						AGAACATAATCATCACAAAGG	0.383000											OREG0022039	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	40					0.014758	0.016011	0.014758	1	0
MON2	23041	broad.mit.edu	37	12	62936948	62936948	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:62936948G>A	ENST00000393630.3	+	20	2827	c.2436G>A	c.(2434-2436)ctG>ctA	p.L812L	MON2_ENST00000393632.2_Silent_p.L812L|MON2_ENST00000552115.1_Silent_p.L812L|MON2_ENST00000393629.2_Silent_p.L812L|MON2_ENST00000280379.6_Silent_p.L812L|MON2_ENST00000546600.1_Silent_p.L812L|MON2_ENST00000552738.1_Silent_p.L789L	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	812					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TAGAAATTCTGTGGAGACCTC	0.313000													11	26					0	0	0.105934	0	0
FMNL2	114793	broad.mit.edu	37	2	153476138	153476138	+	Silent	SNP	T	T	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:153476138T>A	ENST00000288670.9	+	15	2110	c.1743T>A	c.(1741-1743)acT>acA	p.T581T	FMNL2_ENST00000475377.2_5'UTR	NM_052905.3	NP_443137.2	Q96PY5	FMNL2_HUMAN	formin-like 2	581	Pro-rich.				actin cytoskeleton organization	cytoplasm	actin binding|Rho GTPase binding			central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(2)|lung(3)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	23						CAGCTGAGACTGTACCAGCTC	0.637000													3	29					0	0	0.009096	0	0
NEU3	10825	broad.mit.edu	37	11	74716632	74716632	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:74716632T>G	ENST00000294064.4	+	3	1408	c.481T>G	c.(481-483)Ttc>Gtc	p.F161V	NEU3_ENST00000545272.1_Missense_Mutation_p.F52V|NEU3_ENST00000544263.1_Missense_Mutation_p.F128V|NEU3_ENST00000531509.1_Missense_Mutation_p.F161V|NEU3_ENST00000532963.1_Missense_Mutation_p.L90R|NEU3_ENST00000529024.1_Missense_Mutation_p.L90R	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	161										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						CCGCCTTTGCTTCATCTACAG	0.532000													13	77					0	0	0.024245	0	0
HBG2	3048	broad.mit.edu	37	11	5274583	5274583	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:5274583A>C	ENST00000380259.2	-	8	1608	c.368T>G	c.(367-369)tTc>tGc	p.F123C	HBG2_ENST00000380252.1_Missense_Mutation_p.F113C|HBG2_ENST00000336906.4_Missense_Mutation_p.F123C					hemoglobin, gamma G											endometrium(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	13		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCAGGGGTGAATTCTTTGCC	0.522000													7	78					0	0	0.058154	0	0
SACS	26278	broad.mit.edu	37	13	23912692	23912692	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:23912692C>A	ENST00000382298.3	-	10	5911	c.5323G>T	c.(5323-5325)Gct>Tct	p.A1775S	SACS_ENST00000402364.1_Missense_Mutation_p.A1025S|SACS_ENST00000382292.3_Missense_Mutation_p.A1775S	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1775					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTAAATCAGCAATCCTTCTG	0.423000													9	84					3.09899e-07	3.67405e-07	0.047766	1	0
PRDM16	63976	broad.mit.edu	37	1	3327964	3327964	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:3327964G>C	ENST00000378398.3	+	10	1288	c.1206G>C	c.(1204-1206)aaG>aaC	p.K402N	PRDM16_ENST00000514189.1_Missense_Mutation_p.K402N|PRDM16_ENST00000511072.1_Missense_Mutation_p.K402N|PRDM16_ENST00000270722.5_Missense_Mutation_p.K401N|PRDM16_ENST00000442529.2_Missense_Mutation_p.K401N|PRDM16_ENST00000441472.2_Missense_Mutation_p.K401N|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000378391.2_Missense_Mutation_p.K401N			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	401					brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		TCTGCCACAAGTCCTACACGC	0.537000			T	EVI1	"""MDS, AML"""								6	17					0	0	0.038147	0	0
FLT3	2322	broad.mit.edu	37	13	28578244	28578244	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:28578244C>A	ENST00000380982.4	-	24	3017	c.2936G>T	c.(2935-2937)aGc>aTc	p.S979I	FLT3_ENST00000537084.1_Missense_Mutation_p.S935I|FLT3_ENST00000469894.1_5'UTR|FLT3_ENST00000241453.7_Missense_Mutation_p.S976I			P36888	FLT3_HUMAN	fms-related tyrosine kinase 3	976					positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(12329)|kidney(2)|large_intestine(8)|lung(30)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	12390	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CATCTCTCTGCTGAAAGGTCG	0.473000			"""Mis, O"""		"""AML, ALL"""								7	93					5.18039e-06	6.01763e-06	0.038147	1	0
PSMD1	5707	broad.mit.edu	37	2	231926010	231926010	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:231926010G>T	ENST00000308696.6	+	2	208	c.46G>T	c.(46-48)Gaa>Taa	p.E16*	PSMD1_ENST00000409643.1_Nonsense_Mutation_p.E16*|PSMD1_ENST00000373635.4_Nonsense_Mutation_p.E16*	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	16					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	GGATGAAGATGAACCACAGCT	0.328000													3	35					0.00024832	0.000279969	0.009096	1	0
SLC9A1	6548	broad.mit.edu	37	1	27436121	27436121	+	Nonsense_Mutation	SNP	G	G	A	rs150618776		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:27436121G>A	ENST00000263980.3	-	3	1536	c.961C>T	c.(961-963)Cga>Tga	p.R321*	SLC9A1_ENST00000374086.3_Nonsense_Mutation_p.R321*|SLC9A1_ENST00000545949.1_5'UTR	NM_003047.4	NP_003038.2	P19634	SL9A1_HUMAN	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	321					regulation of pH	integral to membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27				UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;2.19e-50)|OV - Ovarian serous cystadenocarcinoma(117;1.8e-29)|Colorectal(126;7.61e-09)|COAD - Colon adenocarcinoma(152;9.32e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000521)|KIRC - Kidney renal clear cell carcinoma(1967;0.00079)|STAD - Stomach adenocarcinoma(196;0.00125)|READ - Rectum adenocarcinoma(331;0.046)	Amiloride(DB00594)	GAGGTAAATCGGGAGGTGAAG	0.597000													4	11					0	0	0.014758	0	0
SPOCK1	6695	broad.mit.edu	37	5	136324155	136324155	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:136324155T>C	ENST00000394945.1	-	8	1053	c.884A>G	c.(883-885)aAg>aGg	p.K295R	SPOCK1_ENST00000509978.1_5'UTR|SPOCK1_ENST00000282223.7_Missense_Mutation_p.K295R	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	295					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTTAGAAAGCTTGCCATCCTT	0.532000													16	129					0	0	0.028581	0	0
CHRM4	1132	broad.mit.edu	37	11	46408021	46408021	+	Silent	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:46408021C>T	ENST00000433765.2	-	1	86	c.87G>A	c.(85-87)acG>acA	p.T29T		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	29					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	CCATTTCCACCGTCTCATAGC	0.567000													3	22					0	0	0.004672	0	0
FILIP1	27145	broad.mit.edu	37	6	76022197	76022197	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:76022197G>A	ENST00000393004.2	-	5	3572	c.3351C>T	c.(3349-3351)tcC>tcT	p.S1117S	FILIP1_ENST00000370020.1_Silent_p.S1018S|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.S1117S			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	1117										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CAGGCCGTGAGGAGAGGTGAT	0.537000													9	144					0	0	0.058154	0	0
IRAK3	11213	broad.mit.edu	37	12	66641740	66641740	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:66641740G>T	ENST00000261233.4	+	12	2001	c.1580G>T	c.(1579-1581)aGa>aTa	p.R527I	IRAK3_ENST00000457197.2_Missense_Mutation_p.R466I	NM_007199.2	NP_009130.2	Q9Y616	IRAK3_HUMAN	interleukin-1 receptor-associated kinase 3	527					interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|negative regulation of innate immune response|negative regulation of interleukin-12 production|negative regulation of interleukin-6 production|negative regulation of macrophage cytokine production|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein catabolic process|negative regulation of protein complex disassembly|negative regulation of toll-like receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of macrophage tolerance induction|positive regulation of NF-kappaB transcription factor activity|response to exogenous dsRNA|response to lipopolysaccharide|response to peptidoglycan	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein heterodimerization activity|protein homodimerization activity|protein serine/threonine kinase activity			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(28;0.0203)		GAGAGCAAGAGAAATGAGGAA	0.433000													14	190					1.49906e-05	1.72392e-05	0.020292	1	0
ACAD8	27034	broad.mit.edu	37	11	134129553	134129553	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:134129553A>G	ENST00000281182.4	+	6	725	c.619A>G	c.(619-621)Aca>Gca	p.T207A	ACAD8_ENST00000374752.4_Missense_Mutation_p.T80A|ACAD8_ENST00000543332.1_Missense_Mutation_p.T109A|ACAD8_ENST00000537423.1_Missense_Mutation_p.T130A|ACAD8_ENST00000524547.1_3'UTR	NM_014384.2	NP_055199.1	Q9UKU7	ACAD8_HUMAN	acyl-CoA dehydrogenase family, member 8	207					branched chain family amino acid catabolic process|lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	14	all_hematologic(175;0.127)	all_cancers(12;8e-23)|all_epithelial(12;2.59e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|all_neural(223;0.0189)|Medulloblastoma(222;0.0245)|Esophageal squamous(93;0.0559)		Epithelial(10;1.92e-10)|all cancers(11;2.26e-09)|BRCA - Breast invasive adenocarcinoma(10;8.73e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00154)|Lung(977;0.21)		CATGTGCCGAACAGGAGGACC	0.542000													6	57					0	0	0.058154	0	0
NAV1	89796	broad.mit.edu	37	1	201757641	201757641	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:201757641G>A	ENST00000367296.4	+	10	3461	c.3041G>A	c.(3040-3042)aGc>aAc	p.S1014N	IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367300.3_Intron|NAV1_ENST00000367295.1_Missense_Mutation_p.S623N|NAV1_ENST00000295624.6_Missense_Mutation_p.S1014N|NAV1_ENST00000367302.1_Intron|NAV1_ENST00000469130.1_3'UTR|NAV1_ENST00000367297.4_Missense_Mutation_p.S1014N	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	1014					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CGCTCCAACAGCATCCCCACC	0.632000													4	171					0	0	0.021553	0	0
HECTD4	283450	broad.mit.edu	37	12	112686139	112686139	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:112686139C>T	ENST00000550722.1	-	26	4085	c.3690G>A	c.(3688-3690)atG>atA	p.M1230I	HECTD4_ENST00000430131.2_Missense_Mutation_p.M954I|HECTD4_ENST00000377560.5_Missense_Mutation_p.M1204I	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		GCTGTCTCTCCATGGCATTGA	0.289000													3	15					0	0	0.009096	0	0
KLHL40	131377	broad.mit.edu	37	3	42733406	42733406	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:42733406T>C	ENST00000287777.4	+	6	1887	c.1787T>C	c.(1786-1788)gTc>gCc	p.V596A		NM_152393.2	NP_689606.2			kelch-like family member 40																		TGGGAGGGTGTCCTGCGGGAG	0.567000													15	162					0	0	0.038395	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13180	13180	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrM:13180G>A	ENST00000361567.2	+	1	844	c.844G>A	c.(844-846)Gct>Act	p.A282T				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	282					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TATGCTTAGGCGCTATCACCA	0.443000													31	330					0	0	0.059317	0	0
DMD	1756	broad.mit.edu	37	X	32509548	32509548	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:32509548A>C	ENST00000357033.4	-	20	2674	c.2468T>G	c.(2467-2469)cTt>cGt	p.L823R	DMD_ENST00000378677.2_Missense_Mutation_p.L819R	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	823					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CAGCCAGTTAAGTCTCTCACT	0.413000													4	27					0	0	0.009096	0	0
NACA2	342538	broad.mit.edu	37	17	59667970	59667970	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:59667970G>A	ENST00000521764.1	-	1	593	c.572C>T	c.(571-573)tCg>tTg	p.S191L		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	191	UBA.				protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					CTTTGCTCTCGACACATTTGC	0.408000													17	198					0	0	0.038395	0	0
DNAJC13	23317	broad.mit.edu	37	3	132172941	132172941	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:132172941C>A	ENST00000260818.6	+	9	1120	c.872C>A	c.(871-873)cCa>cAa	p.P291Q	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	291							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						TCAGAAAATCCACAACTTTTT	0.264000													4	49					0.014758	0.016011	0.014758	1	0
PGBD2	267002	broad.mit.edu	37	1	249211872	249211872	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:249211872G>A	ENST00000355360.4	+	3	606	c.336G>A	c.(334-336)ttG>ttA	p.L112L	PGBD2_ENST00000329291.5_Silent_p.L363L|PGBD2_ENST00000539153.1_Silent_p.L360L	NM_001017434.1	NP_001017434.1	Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	363										NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TGTCCATTTTGAGGAAAAAGG	0.418000													30	102					0	0	0.034045	0	0
TRIM42	287015	broad.mit.edu	37	3	140407231	140407231	+	Silent	SNP	C	C	T	rs148437702		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:140407231C>T	ENST00000286349.3	+	3	1898	c.1707C>T	c.(1705-1707)gaC>gaT	p.D569D		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	569						intracellular	zinc ion binding	p.D569D(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AACCCACAGACGGCCTCTACA	0.572000													23	91					0	0	0.034045	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255686	85255686	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:85255686G>A	ENST00000266682.5	-	12	2459	c.1918C>T	c.(1918-1920)Cgt>Tgt	p.R640C	SLC6A15_ENST00000552192.1_Missense_Mutation_p.R533C|SLC6A15_ENST00000309283.7_Intron	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	640					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TTGAAGCGACGAACAATGAAA	0.443000													59	175					0	0	0.048971	0	0
CNTN5	53942	broad.mit.edu	37	11	100211244	100211244	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:100211244A>G	ENST00000524871.1	+	22	3070	c.2780A>G	c.(2779-2781)aAa>aGa	p.K927R	CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Missense_Mutation_p.K927R|CNTN5_ENST00000418526.2_Missense_Mutation_p.K853R|CNTN5_ENST00000528682.1_Missense_Mutation_p.K927R	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	927	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GAAACAGTCAAAACTAGAGGG	0.408000													14	106					0	0	0.020292	0	0
CDC42	998	broad.mit.edu	37	1	22405022	22405022	+	Translation_Start_Site	SNP	A	A	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:22405022A>C	ENST00000421089.2	+	2	133	c.1A>C	c.(1-3)Atg>Ctg	p.M1L	CDC42_ENST00000315554.8_Silent_p.T17T|CDC42_ENST00000498236.1_3'UTR|CDC42_ENST00000400259.1_Silent_p.T17T|CDC42_ENST00000344548.3_Silent_p.T17T			P60953	CDC42_HUMAN	cell division cycle 42	0					actin cytoskeleton organization|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|establishment or maintenance of cell polarity|macrophage differentiation|muscle cell differentiation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein complex assembly|positive regulation of muscle cell differentiation|positive regulation of pseudopodium assembly|regulation of filopodium assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|filopodium|plasma membrane	GTP binding|GTPase activity|protein binding|thioesterase binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)	12		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)|Prostate(1639;0.0792)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0452)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.35e-07)|COAD - Colon adenocarcinoma(152;7.73e-06)|GBM - Glioblastoma multiforme(114;8.62e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000649)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00767)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.207)		TTGGTAAAACATGTCTCCTGA	0.348000													3	54					0	0	0.009096	0	0
GLUD2	2747	broad.mit.edu	37	X	120181912	120181912	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:120181912A>G	ENST00000328078.1	+	1	451	c.374A>G	c.(373-375)gAc>gGc	p.D125G		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	125					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATCCGGCGCGACGACGGCTCC	0.632000													4	25					0	0	0.014758	0	0
PCLO	27445	broad.mit.edu	37	7	82586125	82586125	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:82586125G>A	ENST00000423517.2	-	5	4481	c.4144C>T	c.(4144-4146)Cca>Tca	p.P1382S	PCLO_ENST00000333891.8_Missense_Mutation_p.P1382S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1313					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCATCAGTTGGAATAAGACTT	0.443000													20	77					0	0	0.043863	0	0
MYH4	4622	broad.mit.edu	37	17	10358095	10358095	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:10358095C>T	ENST00000255381.2	-	22	2578	c.2468G>A	c.(2467-2469)cGt>cAt	p.R823H	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	823					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CATGAAAGCACGGATGTTGTA	0.428000													8	44					0	0	0.058154	0	0
SCG2	7857	broad.mit.edu	37	2	224463855	224463855	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:224463855T>G	ENST00000305409.2	-	2	378	c.146A>C	c.(145-147)aAg>aCg	p.K49T		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	49					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		ACTGGGAAACTTTTGGACATT	0.438000													18	164					0	0	0.043863	0	0
TPMT	7172	broad.mit.edu	37	6	18130960	18130960	+	Missense_Mutation	SNP	C	C	T	rs139392616		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:18130960C>T	ENST00000309983.4	-	9	762	c.677G>A	c.(676-678)cGa>cAa	p.R226Q		NM_000367.2	NP_000358.1	P51580	TPMT_HUMAN	thiopurine S-methyltransferase	226					xenobiotic metabolic process	cytosol	thiopurine S-methyltransferase activity			large_intestine(2)|lung(1)	3	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.146)	all cancers(50;0.06)|Epithelial(50;0.0654)		Mercaptopurine(DB01033)	ACTTTTATGTCGTTCTTCAAA	0.294000													3	33					0	0	0.004672	0	0
POLQ	10721	broad.mit.edu	37	3	121248522	121248522	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:121248522C>G	ENST00000264233.5	-	7	1206	c.1078G>C	c.(1078-1080)Gag>Cag	p.E360Q	POLQ_ENST00000488282.1_5'UTR	NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	360	Helicase C-terminal.				DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		TTATAAAACTCTCGAGCAATG	0.353000								DNA polymerases (catalytic subunits)					12	67					0	0	0.105934	0	0
ABCA13	154664	broad.mit.edu	37	7	48450174	48450174	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:48450174G>A	ENST00000435803.1	+	40	12152	c.12128G>A	c.(12127-12129)cGc>cAc	p.R4043H		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4043	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity	p.R3988H(1)|p.R4043H(1)		breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CTGAGTGACCGCGTGGCCGTC	0.622000													33	236					0	0	0.064281	0	0
COCH	1690	broad.mit.edu	37	14	31354228	31354228	+	Silent	SNP	T	T	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:31354228T>A	ENST00000382493.4	+	3	367	c.267T>A	c.(265-267)tcT>tcA	p.S89S	RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000475087.1_Intron|COCH_ENST00000396618.3_Intron|COCH_ENST00000216361.4_Intron|COCH_ENST00000460581.2_Intron|RP11-829H16.3_ENST00000555421.1_RNA			O43405	COCH_HUMAN	cochlin	244	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CCGTTGACTCTGAAGAGAGAC	0.393000													10	102					0	0	0.069234	0	0
TTN	7273	broad.mit.edu	37	2	179593263	179593263	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:179593263C>A	ENST00000589042.1	-	66	19614	c.19390G>T	c.(19390-19392)Gga>Tga	p.G6464*	TTN_ENST00000591111.1_Nonsense_Mutation_p.G6147*|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Nonsense_Mutation_p.G5220*|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6147	Ig-like 46.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTACTGCTTCCGAAGTCATTT	0.398000													6	43					8.12818e-05	9.25486e-05	0.029380	1	0
CYCS	54205	broad.mit.edu	37	7	25163649	25163649	+	Silent	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:25163649C>T	ENST00000305786.2	-	2	259	c.90G>A	c.(88-90)ggG>ggA	p.G30G	CYCS_ENST00000409409.1_Silent_p.G30G|CYCS_ENST00000409764.1_Silent_p.G30G	NM_018947.5	NP_061820.1	P99999	CYC_HUMAN	cytochrome c, somatic	30					activation of caspase activity by cytochrome c|DNA fragmentation involved in apoptotic nuclear change|induction of apoptosis by intracellular signals|respiratory electron transport chain|transport	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|mitochondrial matrix|nucleus|protein phosphatase type 2A complex|respiratory chain	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity|heme binding|protein binding			endometrium(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	4					Melatonin(DB01065)|Minocycline(DB01017)	GGAGATTTGGCCCAGTCTTGT	0.443000													3	34					0	0	0.004672	0	0
FLG	2312	broad.mit.edu	37	1	152275390	152275390	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:152275390A>T	ENST00000368799.1	-	3	12007	c.11972T>A	c.(11971-11973)tTt>tAt	p.F3991Y	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3991					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGAGTGTCTAAACCCGGATTC	0.403000									Ichthyosis				6	83					0	0	0.021553	0	0
GLP2R	9340	broad.mit.edu	37	17	9739737	9739737	+	Silent	SNP	T	T	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:9739737T>G	ENST00000262441.5	+	3	840	c.327T>G	c.(325-327)tcT>tcG	p.S109S	GLP2R_ENST00000574745.1_5'UTR	NM_004246.1	NP_004237.1	O95838	GLP2R_HUMAN	glucagon-like peptide 2 receptor	109					G-protein signaling, coupled to cAMP nucleotide second messenger|positive regulation of cell proliferation	integral to membrane|plasma membrane				endometrium(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	44					Glucagon recombinant(DB00040)	GGCCTCATTCTTCTCCTGGAA	0.418000													12	124					0	0	0.024245	0	0
NBEA	26960	broad.mit.edu	37	13	35672502	35672502	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:35672502G>T	ENST00000540320.1	+	11	2174	c.1640G>T	c.(1639-1641)gGt>gTt	p.G547V	NBEA_ENST00000400445.3_Missense_Mutation_p.G547V|NBEA_ENST00000379939.2_Missense_Mutation_p.G547V|NBEA_ENST00000310336.4_Missense_Mutation_p.G547V			Q8NFP9	NBEA_HUMAN	neurobeachin	547						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CAGATGCTGGGTGGAAAAGGC	0.383000													4	52					0.00116845	0.00129203	0.021553	1	0
FAM134C	162427	broad.mit.edu	37	17	40761280	40761280	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:40761280G>A	ENST00000309428.5	-	1	122	c.63C>T	c.(61-63)ggC>ggT	p.G21G	FAM134C_ENST00000543197.1_5'UTR|FAM134C_ENST00000585894.1_Intron	NM_178126.3	NP_835227.1	Q86VR2	F134C_HUMAN	family with sequence similarity 134, member C	21						integral to membrane				endometrium(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	11		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.134)		CATCTCGGCGGCCCCTGAAAG	0.716000													4	11					0	0	0.014758	0	0
PRRC2B	84726	broad.mit.edu	37	9	134351251	134351251	+	Silent	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:134351251C>T	ENST00000357304.4	+	15	3790	c.3735C>T	c.(3733-3735)tgC>tgT	p.C1245C	PRRC2B_ENST00000405995.1_Intron|PRRC2B_ENST00000372249.1_5'UTR|PRRC2B_ENST00000458550.1_Intron	NM_013318.3	NP_037450.2	Q5JSZ5	PRC2B_HUMAN	proline-rich coiled-coil 2B	1245							protein binding			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(20)|ovary(2)	44						CCGACACATGCGGATCCCGGC	0.592000											OREG0019561	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	17					0	0	0.021553	0	0
CWC25	54883	broad.mit.edu	37	17	36958457	36958457	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:36958457C>T	ENST00000225428.4	-	10	1463	c.1166G>A	c.(1165-1167)cGc>cAc	p.R389H	CWC25_ENST00000536127.1_Missense_Mutation_p.R326H	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	389								p.R389H(1)		central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						CAGCTTCATGCGGCTAGGAAG	0.453000													9	19					0	0	0.080935	0	0
HEPACAM2	253012	broad.mit.edu	37	7	92844778	92844778	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:92844778G>C	ENST00000394468.2	-	3	728	c.651C>G	c.(649-651)taC>taG	p.Y217*	HEPACAM2_ENST00000341723.4_Nonsense_Mutation_p.Y205*|HEPACAM2_ENST00000440868.1_Nonsense_Mutation_p.Y205*|HEPACAM2_ENST00000453812.2_Nonsense_Mutation_p.Y240*	NM_001039372.1	NP_001034461.1	A8MVW5	HECA2_HUMAN	HEPACAM family member 2	217	Ig-like C2-type 1.					integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(4)|skin(1)	28						CCAGGCAGCTGTAATTCCCAA	0.398000													5	69					0	0	0.021553	0	0
DPYD	1806	broad.mit.edu	37	1	98187108	98187108	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:98187108C>A	ENST00000370192.3	-	5	541	c.441G>T	c.(439-441)gaG>gaT	p.E147D	DPYD_ENST00000474241.1_5'UTR|DPYD_ENST00000306031.5_Missense_Mutation_p.E147D|DPYD_ENST00000423006.2_Missense_Mutation_p.E110D	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	147					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	TAATGGGTCCCTCTTCAGTGG	0.418000													15	62					1.02788e-11	1.27104e-11	0.033300	1	0
TP53	7157	broad.mit.edu	37	17	7577536	7577536	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:7577536T>C	ENST00000420246.2	-	7	877	c.745A>G	c.(745-747)Agg>Ggg	p.R249G	TP53_ENST00000269305.4_Missense_Mutation_p.R249G|TP53_ENST00000455263.2_Missense_Mutation_p.R249G|TP53_ENST00000413465.2_Missense_Mutation_p.R249G|TP53_ENST00000445888.2_Missense_Mutation_p.R249G|TP53_ENST00000359597.4_Missense_Mutation_p.R249G	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	249	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in a sporadic cancer; somatic mutation).|R -> K (in sporadic cancers; somatic mutation).|R -> M (in sporadic cancers; somatic mutation).|R -> N (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|R -> S (in sporadic cancers; somatic mutation; dbSNP:rs28934571).|R -> T (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|RP -> SA (in a sporadic cancer; somatic mutation).|RP -> SS (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R249W(37)|p.R249G(30)|p.0?(8)|p.?(5)|p.M246_P250delMNRRP(2)|p.R249R(1)|p.R248_P250delRRP(1)|p.R249_P250delRP(1)|p.N247_R248delNR(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.G245fs*14(1)|p.R249fs*15(1)|p.R249fs*14(1)|p.R249_T256delRPILTIIT(1)|p.R249fs*19(1)|p.R249_I251delRPI(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGATGGGCCTCCGGTTCATG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	35					0	0	0.028581	0	0
PDE3A	5139	broad.mit.edu	37	12	20769252	20769252	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:20769252T>A	ENST00000359062.3	+	4	1398	c.1358T>A	c.(1357-1359)tTg>tAg	p.L453*	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	453					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTACCCACCTTGGAGCCTGCA	0.557000													7	64					0	0	0.047766	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599245	136599245	+	Silent	SNP	A	A	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:136599245A>C	ENST00000531224.1	-	4	1026	c.774T>G	c.(772-774)ccT>ccG	p.P258P	BCLAF1_ENST00000353331.4_Silent_p.P256P|BCLAF1_ENST00000392348.2_Silent_p.P256P|BCLAF1_ENST00000527536.1_Silent_p.P258P|BCLAF1_ENST00000527759.1_Silent_p.P256P|BCLAF1_ENST00000530767.1_Silent_p.P258P	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	258					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AATGCTGAGAAGGAGTATTTT	0.453000													3	71					0	0	0.004672	0	0
RAB2B	84932	broad.mit.edu	37	14	21944687	21944687	+	Splice_Site	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:21944687C>T	ENST00000397762.1	-	2	218	c.118_splice	c.e2+1	p.G40_splice	RAB2B_ENST00000461909.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	40					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		ATGCACTTACCTATTGTGAGG	0.443000													14	20					0	0	0.038395	0	0
COL11A2	1302	broad.mit.edu	37	6	33139548	33139548	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:33139548G>A	ENST00000341947.2	-	42	3319	c.3092C>T	c.(3091-3093)cCg>cTg	p.P1031L	COL11A2_ENST00000374712.1_Missense_Mutation_p.P950L|COL11A2_ENST00000477772.1_Intron|COL11A2_ENST00000374708.4_Missense_Mutation_p.P945L|COL11A2_ENST00000357486.1_Missense_Mutation_p.P1010L|COL11A2_ENST00000374714.1_Missense_Mutation_p.P1005L|COL11A2_ENST00000361917.1_Missense_Mutation_p.P924L|COL11A2_ENST00000374713.1_Missense_Mutation_p.P984L|COL11A2_ENST00000395197.1_Missense_Mutation_p.P971L	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1031	Triple-helical region.			PP -> RQ (in Ref. 1; AAC50213/AAC50214/ AAC50215 and 6; AAA52034).	cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging	p.P1031L(1)		biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GCGCCCTGGCGGACCAATGGG	0.667000													6	10					0	0	0.021553	0	0
TLN1	7094	broad.mit.edu	37	9	35714249	35714249	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:35714249G>A	ENST00000314888.9	-	24	3460	c.3107C>T	c.(3106-3108)aCg>aTg	p.T1036M	TLN1_ENST00000540444.1_Missense_Mutation_p.T1036M	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1036					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CTGGGCAGCCGTCCGGAGTTC	0.557000													15	44					0	0	0.028581	0	0
HGF	3082	broad.mit.edu	37	7	81372779	81372779	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:81372779T>G	ENST00000222390.5	-	7	981	c.755A>C	c.(754-756)gAc>gCc	p.D252A	HGF_ENST00000453411.1_Missense_Mutation_p.D247A|HGF_ENST00000444829.2_Missense_Mutation_p.D252A|HGF_ENST00000457544.2_Missense_Mutation_p.D247A	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	252	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						AAAGCCCTTGTCGGGATATCT	0.498000													4	77					0	0	0.014758	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13208	13208	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrM:13208G>A	ENST00000361567.2	+	1	872	c.872G>A	c.(871-873)tGc>tAc	p.C291Y				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	291					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	CGCAGCAGTCTGCGCCCTTAC	0.453000													5	371					0	0	0.021553	0	0
MYO9A	4649	broad.mit.edu	37	15	72141239	72141239	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:72141239C>G	ENST00000356056.5	-	39	7256	c.6784G>C	c.(6784-6786)Gaa>Caa	p.E2262Q	MYO9A_ENST00000564571.1_Missense_Mutation_p.E2262Q|MYO9A_ENST00000424560.1_Missense_Mutation_p.E2333Q|MYO9A_ENST00000444904.1_Missense_Mutation_p.E2243Q	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2262	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TCAGCAAATTCCAAGCTACTG	0.388000													8	34					0	0	0.038147	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686548	125686548	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:125686548G>A	ENST00000371126.1	-	1	286	c.44C>T	c.(43-45)gCg>gTg	p.A15V		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	15								p.A15V(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CGCCTCGACCGCGGGCGCTTT	0.726000													6	13					0	0	0.038147	0	0
GJA8	2703	broad.mit.edu	37	1	147380379	147380379	+	Silent	SNP	C	C	T	rs142426709		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:147380379C>T	ENST00000240986.4	+	2	350	c.297C>T	c.(295-297)taC>taT	p.Y99Y	GJA8_ENST00000369235.1_Silent_p.Y99Y	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	99					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CGGTGCACTACGTCCGCATGG	0.652000													19	52					0	0	0.069288	0	0
MOCS3	27304	broad.mit.edu	37	20	49575564	49575564	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:49575564G>A	ENST00000244051.1	+	1	202	c.185G>A	c.(184-186)cGc>cAc	p.R62H		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	62					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						GAGATTCTGCGCTATAGCCGG	0.682000													12	24					0	0	0.049695	0	0
NELL1	4745	broad.mit.edu	37	11	20959354	20959354	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:20959354A>T	ENST00000298925.5	+	11	1257	c.1104A>T	c.(1102-1104)aaA>aaT	p.K368N	NELL1_ENST00000532434.1_Missense_Mutation_p.K340N|NELL1_ENST00000325319.5_Missense_Mutation_p.K283N|NELL1_ENST00000357134.5_Missense_Mutation_p.K340N			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	340	VWFC 2.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity	p.K340N(1)		NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						ATGGAGGAAAAGTTCTTGCAG	0.403000													9	188					0	0	0.058154	0	0
HSPA5	3309	broad.mit.edu	37	9	128001021	128001021	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:128001021A>T	ENST00000324460.6	-	6	1285	c.1082T>A	c.(1081-1083)cTt>cAt	p.L361H		NM_005347.4	NP_005338.1	P11021	GRP78_HUMAN	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	361					anti-apoptosis|cellular response to glucose starvation|ER-associated protein catabolic process|platelet activation|platelet degranulation|regulation of protein folding in endoplasmic reticulum	cell surface|endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|ER-Golgi intermediate compartment|integral to endoplasmic reticulum membrane|melanosome|midbody|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|calcium ion binding|caspase inhibitor activity|chaperone binding|misfolded protein binding|protein binding, bridging|protein domain specific binding|ubiquitin protein ligase binding|unfolded protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(4)|prostate(2)|skin(1)	23					Antihemophilic Factor(DB00025)	GCCACCAACAAGAACAATTTC	0.418000										Prostate(1;0.17)			4	28					0	0	0.009096	0	0
METTL25	84190	broad.mit.edu	37	12	82792957	82792957	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:82792957T>G	ENST00000248306.3	+	4	984	c.915T>G	c.(913-915)aaT>aaG	p.N305K	METTL25_ENST00000547357.1_3'UTR	NM_032230.2	NP_115606.2			methyltransferase like 25																		AAGAAGAAAATTTGTGTTTTG	0.363000													21	63					0	0	0.069288	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110441625	110441625	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:110441625G>C	ENST00000378402.5	+	26	3161	c.3057G>C	c.(3055-3057)aaG>aaC	p.K1019N		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1019					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CAAGGATAAAGGAAGGTGGCT	0.333000										HNSCC(38;0.096)			5	22					0	0	0.014758	0	0
GAB2	9846	broad.mit.edu	37	11	77937572	77937572	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:77937572G>A	ENST00000361507.4	-	4	1231	c.1146C>T	c.(1144-1146)gtC>gtT	p.V382V	GAB2_ENST00000340149.2_Silent_p.V344V	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	382					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TGGTGGCAGCGACAGATCTGC	0.587000													4	68					0	0	0.009096	0	0
ROBO1	6091	broad.mit.edu	37	3	78795962	78795962	+	Silent	SNP	G	G	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:78795962G>T	ENST00000436010.2	-	3	1468	c.471C>A	c.(469-471)ggC>ggA	p.G157G	ROBO1_ENST00000495273.1_Silent_p.G157G|ROBO1_ENST00000467549.1_Silent_p.G157G|ROBO1_ENST00000464233.1_Silent_p.G196G			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	196	Ig-like C2-type 1.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GCTCAGGATGGCCTCGTGGAG	0.453000													17	70					1.99824e-07	2.39372e-07	0.033300	1	0
MRPL21	219927	broad.mit.edu	37	11	68660338	68660338	+	Silent	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:68660338C>T	ENST00000567045.1	-	6	553	c.318G>A	c.(316-318)ccG>ccA	p.P106P	MRPL21_ENST00000450904.2_Intron|MRPL21_ENST00000362034.2_Intron			Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21	0					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome			large_intestine(1)|lung(6)|prostate(1)	8			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CAGGGCCCAGCGGTACTTTCT	0.522000													3	16					0	0	0.004672	0	0
DSCAM	1826	broad.mit.edu	37	21	41710046	41710046	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:41710046C>T	ENST00000400454.1	-	8	2242	c.1765G>A	c.(1765-1767)Gtc>Atc	p.V589I		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	589	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTCACGTGGACGCTCTGGCTG	0.502000													27	73					0	0	0.054565	0	0
LILRB1	10859	broad.mit.edu	37	19	55142481	55142481	+	Missense_Mutation	SNP	G	G	A	rs114930141	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:55142481G>A	ENST00000427581.2	+	1	398	c.65G>A	c.(64-66)cGa>cAa	p.R22Q	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396331.1_5'UTR|LILRB1_ENST00000396327.3_5'UTR|LILRB1_ENST00000434867.2_5'UTR|LILRB1_ENST00000324602.7_5'UTR|LILRB1_ENST00000396332.4_5'UTR|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000418536.2_Intron			Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TGCCAGCACCGAGGGCTCATC	0.582000										HNSCC(37;0.09)			8	33					0	0	0.047766	0	0
IQGAP3	128239	broad.mit.edu	37	1	156524106	156524106	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:156524106G>A	ENST00000361170.2	-	13	1379	c.1369C>T	c.(1369-1371)Cgg>Tgg	p.R457W		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	457					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGGCATCCCGGGCCTCCAGG	0.617000													8	15					0	0	0.093190	0	0
AGTR2	186	broad.mit.edu	37	X	115304268	115304268	+	Silent	SNP	G	G	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:115304268G>T	ENST00000371906.4	+	3	925	c.735G>T	c.(733-735)ggG>ggT	p.G245G		NM_000686.4	NP_000677.2	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	245					behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|skin(1)	24						ATAGCTATGGGAAGAACAGGA	0.408000													8	160					7.48243e-07	8.7804e-07	0.058154	1	0
CASP14	23581	broad.mit.edu	37	19	15164395	15164395	+	Missense_Mutation	SNP	C	C	T	rs61731993		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:15164395C>T	ENST00000427043.3	+	3	438	c.130C>T	c.(130-132)Cgg>Tgg	p.R44W	CASP14_ENST00000221740.1_Missense_Mutation_p.R44W	NM_012114.2	NP_036246.1	P31944	CASPE_HUMAN	caspase 14, apoptosis-related cysteine peptidase	44					apoptosis|cell differentiation|epidermis development|proteolysis	cytoplasm|nucleus	cysteine-type endopeptidase activity	p.R44W(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|prostate(1)|skin(3)	26						ACACATGTTTCGGCAGCTGAG	0.532000													5	259					0	0	0.014758	0	0
KCNK6	9424	broad.mit.edu	37	19	38817875	38817875	+	Silent	SNP	C	C	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:38817875C>T	ENST00000263372.3	+	3	881	c.774C>T	c.(772-774)caC>caT	p.H258H		NM_004823.1	NP_004814.1	Q9Y257	KCNK6_HUMAN	potassium channel, subfamily K, member 6	258						voltage-gated potassium channel complex	inward rectifier potassium channel activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)	17	all_cancers(60;5.83e-07)		Lung(45;0.00047)|LUSC - Lung squamous cell carcinoma(53;0.000613)		Ibutilide(DB00308)|Quinidine(DB00908)	CCTTCCGCCACGTGTCCGACC	0.637000													3	8					0	0	0.004672	0	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G|EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	17					0	0	0.014758	0	0
ABCC9	10060	broad.mit.edu	37	12	22012522	22012522	+	Silent	SNP	A	A	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:22012522A>G	ENST00000261200.4	-	20	2502	c.2503T>C	c.(2503-2505)Ttg>Ctg	p.L835L	RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000345162.2_Silent_p.L799L|ABCC9_ENST00000261201.4_Silent_p.L835L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	835	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	ATTCTTACCAAAAAGACAATG	0.428000													7	236					0	0	0.047766	0	0
COCH	1690	broad.mit.edu	37	14	31354229	31354229	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:31354229G>A	ENST00000382493.4	+	3	368	c.268G>A	c.(268-270)Gaa>Aaa	p.E90K	RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000475087.1_Intron|COCH_ENST00000396618.3_Intron|COCH_ENST00000216361.4_Intron|COCH_ENST00000460581.2_Intron|RP11-829H16.3_ENST00000555421.1_RNA			O43405	COCH_HUMAN	cochlin	244	LCCL.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CGTTGACTCTGAAGAGAGACT	0.398000													10	102					0	0	0.069234	0	0
PSG5	5673	broad.mit.edu	37	19	43689118	43689118	+	Nonsense_Mutation	SNP	A	A	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:43689118A>C	ENST00000404580.1	-	2	334	c.246T>G	c.(244-246)taT>taG	p.Y82*	PSG5_ENST00000599812.1_Nonsense_Mutation_p.Y82*|PSG5_ENST00000407568.1_Nonsense_Mutation_p.Y82*|PSG5_ENST00000407356.1_Nonsense_Mutation_p.Y82*|PSG5_ENST00000366175.3_Nonsense_Mutation_p.Y82*|PSG5_ENST00000401992.1_5'UTR|PSG5_ENST00000342951.6_Nonsense_Mutation_p.Y82*			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	82	Ig-like V-type.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				CGTCTACTACATATGATGTAA	0.428000													4	326					0	0	0.021553	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432692	140432692	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:140432692T>G	ENST00000306549.3	+	1	1714	c.1637T>G	c.(1636-1638)gTt>gGt	p.V546G		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		546	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTAGCCAAGTTACTGTCAGA	0.488000													6	31					0	0	0.029380	0	0
TSPEAR	54084	broad.mit.edu	37	21	45941910	45941910	+	Silent	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:45941910G>A	ENST00000323084.4	-	9	1487	c.1422C>T	c.(1420-1422)tcC>tcT	p.S474S	TSPEAR_ENST00000397916.1_Silent_p.S406S|C21orf90_ENST00000465978.1_Intron	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	474					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						CGTAGGCGCCGGAGGTGGCGA	0.607000													7	29					0	0	0.069234	0	0
MYH2	4620	broad.mit.edu	37	17	10432234	10432234	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:10432234G>A	ENST00000245503.5	-	27	3901	c.3517C>T	c.(3517-3519)Cgg>Tgg	p.R1173W	MYH2_ENST00000397183.2_Missense_Mutation_p.R1173W|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1173					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCAGCCTCCCGCTTCTTGTTC	0.597000													20	56					0	0	0.037714	0	0
PNPLA5	150379	broad.mit.edu	37	22	44282341	44282341	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr22:44282341G>A	ENST00000216177.4	-	6	923	c.791C>T	c.(790-792)aCg>aTg	p.T264M	PNPLA5_ENST00000593866.1_Missense_Mutation_p.T150M|PNPLA5_ENST00000381198.2_Missense_Mutation_p.T150M|PNPLA5_ENST00000597664.1_Missense_Mutation_p.T264M	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	264					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				AGACACCAGCGTCCATAGCAC	0.617000													3	14					0	0	0.021553	0	0
LOC101928460	101928460	broad.mit.edu	37	1	29667663	29667664	+	RNA	INS	-	-	G	rs77252284	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:29667663_29667664insG	ENST00000417651.1	-	0	432																											GGCATTTCtttgtttttttttt	0.421													4	2	---	---	---	---					
RP11-84A19.4	0	broad.mit.edu	37	1	32324916	32324919	+	RNA	DEL	GATA	GATA	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:32324916_32324919delGATA	ENST00000602889.1	-	0	485																											atagatgattgatagatagataga	0.353													7	5	---	---	---	---					
AL591415.1	0	broad.mit.edu	37	1	48086773	48086774	+	RNA	INS	-	-	TCTC	rs147557102	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:48086773_48086774insTCTC	ENST00000408520.1	-	0	75_76																											CTCTCTATATATATATATATAT	0.441													3	3	---	---	---	---					
RP11-191G24.1	0	broad.mit.edu	37	1	52002982	52002983	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:52002982_52002983insT	ENST00000426017.1	+	0	64				RP11-191G24.1_ENST00000415031.1_RNA																							gtcttcatcacttttttttaac	0.391													2	4	---	---	---	---					
RP4-660H19.1	0	broad.mit.edu	37	1	73297282	73297282	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:73297282delA	ENST00000445976.1	-	0	280																											tgcaaaactgaacagagaatg	0.423													2	4	---	---	---	---					
LOC101928241	101928241	broad.mit.edu	37	1	96814288	96814288	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:96814288delT	ENST00000435311.1	-	0	165																											taaatttagatttttttttgt	0.308													2	4	---	---	---	---					
LOC100129620	100129620	broad.mit.edu	37	1	99585720	99585720	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:99585720delA	ENST00000425113.1	+	0	370					NR_033940.1																						AACaaaaaagaaaaaaaaaat	0.338													2	4	---	---	---	---					
VAV3-AS1	100873946	broad.mit.edu	37	1	108521388	108521389	+	RNA	INS	-	-	A	rs35876111		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:108521388_108521389insA	ENST00000438318.1	+	0	62					NR_046653.1																						tccatctcaggaaaaaaaaaga	0.460													2	4	---	---	---	---					
RP5-965F6.2	0	broad.mit.edu	37	1	112832923	112832924	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:112832923_112832924insA	ENST00000427290.1	-	0	167																											aaatggaaaacaaaaaaaaagc	0.401													2	4	---	---	---	---					
RP5-965F6.2	0	broad.mit.edu	37	1	112847900	112847900	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:112847900delA	ENST00000427290.1	-	0	167																											ATCTGCAATCAAAAAAGGAGT	0.403													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142672993	142672993	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:142672993delC	ENST00000369381.2	-	0	2507																											CTGctgaccaccccccactaa	0.517													4	5	---	---	---	---					
LOC646268	646268	broad.mit.edu	37	1	158102709	158102710	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:158102709_158102710insT	ENST00000414848.1	-	0	221					NR_033946.1																						AGTCCACCATGTTTTTTTTCAa	0.421													2	4	---	---	---	---					
RP11-550P17.5	0	broad.mit.edu	37	1	159344691	159344692	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:159344691_159344692insA	ENST00000431862.1	-	0	227																											ccattcaaaggaaaaaaaataa	0.297													2	4	---	---	---	---					
LINC00626	79100	broad.mit.edu	37	1	168756802	168756803	+	RNA	DEL	GT	GT	-	rs114189563	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:168756802_168756803delGT	ENST00000420691.1	+	0	290					NR_024160.1																						CTCAGGAAGGgtgtgtgtgtgt	0.391													3	5	---	---	---	---					
RP1-15D23.2	0	broad.mit.edu	37	1	172757221	172757222	+	RNA	INS	-	-	C	rs12083405		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:172757221_172757222insC	ENST00000432694.1	+	0	223																											gtttccccaggccccaggtagg	0.485													2	4	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187086279	187086280	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:187086279_187086280insA	ENST00000458683.1	+	0	105																											ATTTATCACATAAAAAGTTACA	0.376													2	4	---	---	---	---					
RP11-669M2.1	0	broad.mit.edu	37	1	188503712	188503714	+	RNA	DEL	CTT	CTT	-	rs4067535		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:188503712_188503714delCTT	ENST00000426262.1	+	0	310																											taaaaaagaacttctatatgctc	0.281													5	1	---	---	---	---					
RP11-398M15.1	0	broad.mit.edu	37	1	189750992	189750992	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:189750992delG	ENST00000419614.1	+	0	179																											ccagccacatgggaaaagttc	0.473													2	4	---	---	---	---					
PROX1-AS1	100505832	broad.mit.edu	37	1	214144858	214144859	+	RNA	INS	-	-	A	rs71165941	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr1:214144858_214144859insA	ENST00000601744.1	-	0	111				PROX1-AS1_ENST00000451396.2_RNA|PROX1-AS1_ENST00000598091.1_RNA|PROX1-AS1_ENST00000601854.1_RNA																							TCACCAAAATTAAAAAAAAAAT	0.351													2	4	---	---	---	---					
AC018685.1	0	broad.mit.edu	37	2	2652475	2652477	+	RNA	DEL	AAA	AAA	-	rs67265772		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:2652475_2652477delAAA	ENST00000414065.1	-	0	135																											actctgtctcaaaaaaaaaaaaa	0.404													2	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14452442	14452442	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:14452442delT	ENST00000418420.1	-	0	251					NR_103814.1																						GACAAAAAGCTTACACAACAG	0.383													2	4	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14518374	14518375	+	RNA	DEL	AA	AA	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:14518374_14518375delAA	ENST00000418420.1	-	0	116					NR_103814.1																						caagcatgcgaaaaaaaaaaag	0.356													2	4	---	---	---	---					
AC010880.1	0	broad.mit.edu	37	2	16562884	16562884	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:16562884delA	ENST00000427950.1	+	0	83																											atgcttgagcaaagacttgaa	0.473													2	4	---	---	---	---					
AC010880.1	0	broad.mit.edu	37	2	16581754	16581754	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:16581754delG	ENST00000427950.1	+	0	157																											CAACCGCACAGGGGATTTTCC	0.567													2	4	---	---	---	---					
LOC728730	728730	broad.mit.edu	37	2	39804609	39804609	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:39804609delA	ENST00000449569.1	+	0	538				AC007246.3_ENST00000425775.1_RNA|AC007246.3_ENST00000438649.1_RNA|AC007246.3_ENST00000426083.1_RNA|AC007246.3_ENST00000451547.1_RNA|AC007246.3_ENST00000422128.1_RNA|AC007246.3_ENST00000446698.1_RNA|AC007246.3_ENST00000415640.1_RNA	NR_037875.1																						atattggtctaaagttctctt	0.408													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51898117	51898118	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:51898117_51898118insT	ENST00000440698.1	+	0	753																											ATGCTTCTCAATTTTTTGTCTC	0.386													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52067936	52067937	+	RNA	DEL	TT	TT	-	rs147170245		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:52067936_52067937delTT	ENST00000440698.1	+	0	839																											tttttcattcttttttttttaa	0.366													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52223942	52223943	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:52223942_52223943insC	ENST00000440698.1	+	0	879																											CTCCACTGCAGCCCCAAGCCCT	0.411													2	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	59225237	59225238	+	RNA	INS	-	-	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:59225237_59225238insG	ENST00000452840.1	+	0	815																											CGTAGGCTAATGGGGGAAAATA	0.332													2	4	---	---	---	---					
LOC101927285	101927285	broad.mit.edu	37	2	59463316	59463317	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:59463316_59463317insC	ENST00000409590.1	+	0	67				RP11-444A22.1_ENST00000606382.1_lincRNA																							ATCTCTCCCCTCCCCCCACTGT	0.386													2	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59839749	59839750	+	RNA	INS	-	-	T	rs61027448		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:59839749_59839750insT	ENST00000606382.1	-	0	236																											aactcttctacttttttttttt	0.292													4	2	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59916136	59916136	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:59916136delA	ENST00000606382.1	-	0	236																											gaacttaaataaaaaaaaaaa	0.363													2	4	---	---	---	---					
LOC100507073	100507073	broad.mit.edu	37	2	66890462	66890463	+	RNA	DEL	TG	TG	-	rs34214494		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:66890462_66890463delTG	ENST00000433396.1	+	0	136																											TTCTTTCTTCTGTGTGTCAACA	0.416													5	1	---	---	---	---					
PCBP1-AS1	400960	broad.mit.edu	37	2	70243994	70243995	+	RNA	INS	-	-	A	rs34269434		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:70243994_70243995insA	ENST00000435880.2	-	0	651				PCBP1-AS1_ENST00000413436.1_RNA|PCBP1-AS1_ENST00000418564.1_RNA|PCBP1-AS1_ENST00000418308.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000415742.1_RNA|PCBP1-AS1_ENST00000411429.1_RNA|PCBP1-AS1_ENST00000434781.1_RNA|PCBP1-AS1_ENST00000419963.1_RNA|PCBP1-AS1_ENST00000423402.1_RNA|PCBP1-AS1_ENST00000420309.1_RNA|PCBP1-AS1_ENST00000599673.1_RNA|PCBP1-AS1_ENST00000601431.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA|PCBP1-AS1_ENST00000456161.1_RNA|PCBP1-AS1_ENST00000457076.1_RNA|PCBP1-AS1_ENST00000594376.2_RNA|PCBP1-AS1_ENST00000415222.1_RNA	NR_033872.1																						caccaagggagaaaaaaaaaaa	0.411													3	5	---	---	---	---					
LINC00152	112597	broad.mit.edu	37	2	87780484	87780485	+	RNA	INS	-	-	AC			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:87780484_87780485insAC	ENST00000409054.1	+	0	278					NR_015395.1																						aaaaACCAAATacacacacaca	0.376													4	4	---	---	---	---					
LOC101928371	101928371	broad.mit.edu	37	2	88848608	88848608	+	RNA	DEL	T	T	-	rs11347188		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:88848608delT	ENST00000413234.1	+	0	650																											ctttctttccttttttttttt	0.443													2	4	---	---	---	---					
AC108051.1	0	broad.mit.edu	37	2	103586073	103586073	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:103586073delT	ENST00000431897.1	-	0	221																											AATATATTCATTTTGGAATTA	0.303													2	4	---	---	---	---					
AC023347.1	0	broad.mit.edu	37	2	127094586	127094587	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:127094586_127094587insA	ENST00000435352.1	+	0	373																											aaatggaaaacaaaaaaaaaga	0.351													3	4	---	---	---	---					
AC097532.2	0	broad.mit.edu	37	2	133050246	133050246	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:133050246delT	ENST00000440802.1	-	0	60																											tttctggctgttttttttttg	0.294													2	4	---	---	---	---					
AC012501.2	0	broad.mit.edu	37	2	154287662	154287662	+	RNA	DEL	A	A	-	rs79784572		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:154287662delA	ENST00000424322.1	-	0	429																											agactctgtcaaaaaaaaaaa	0.393													2	4	---	---	---	---					
AC016723.4	0	broad.mit.edu	37	2	168784710	168784711	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:168784710_168784711insA	ENST00000436982.2	-	0	36																											actctgtctagaaaaaaaaaga	0.436													2	4	---	---	---	---					
AC007319.1	0	broad.mit.edu	37	2	188161212	188161213	+	RNA	DEL	AT	AT	-	rs146893991		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:188161212_188161213delAT	ENST00000412276.1	+	0	189				AC007319.1_ENST00000453517.1_RNA																							ctctcacaacatgtgggaatta	0.401													6	0	---	---	---	---					
AOX2P	344454	broad.mit.edu	37	2	201642230	201642230	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:201642230delT	ENST00000467645.1	+	0	757					NR_001557.4																						tgtcatggactttggagtcac	0.408													2	4	---	---	---	---					
AC107218.3	0	broad.mit.edu	37	2	215528714	215528714	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:215528714delG	ENST00000437883.1	-	0	132				AC107218.3_ENST00000412896.1_RNA																							agaccatcctggctaacatgg	0.547													2	4	---	---	---	---					
AC012668.1	0	broad.mit.edu	37	2	216400352	216400353	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:216400352_216400353insT	ENST00000431727.2	-	0	323																											ATTTTATACTCTTTTTAAGCAA	0.257													2	4	---	---	---	---					
AC114765.1	0	broad.mit.edu	37	2	221184136	221184137	+	RNA	INS	-	-	A	rs34635617		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:221184136_221184137insA	ENST00000432993.1	+	0	306																											actccatctccaaaaaaaaaaa	0.406													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221356582	221356583	+	RNA	INS	-	-	TTCA	rs71916627	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:221356582_221356583insTTCA	ENST00000414512.1	+	0	368																											ACTTCAAAGGCTTCAGCAGCCT	0.446													2	4	---	---	---	---					
AC010149.4	0	broad.mit.edu	37	2	231436150	231436150	+	RNA	DEL	C	C	-	rs59237846		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:231436150delC	ENST00000455357.1	-	0	361				AC010149.4_ENST00000414539.1_RNA																							ctaaagcagaccttctgcctg	0.547													4	3	---	---	---	---					
AC079135.1	0	broad.mit.edu	37	2	237200946	237200946	+	RNA	DEL	T	T	-	rs112406422		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:237200946delT	ENST00000415226.1	+	0	397																											TTGCAAAGTATTTTTTTTTTT	0.448													3	5	---	---	---	---					
LINC01107	151171	broad.mit.edu	37	2	239429671	239429672	+	RNA	INS	-	-	TGG	rs140915729	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr2:239429671_239429672insTGG	ENST00000446979.1	-	0	718					NR_037809.1																						ggtgatggtgatggtggtaata	0.500													2	4	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12063578	12063578	+	RNA	DEL	A	A	-	rs76652649		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:12063578delA	ENST00000432424.2	+	0	549							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						gctctgtgtcaaaaaaaaaaa	0.458													3	3	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12075006	12075006	+	RNA	DEL	T	T	-	rs10708432		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:12075006delT	ENST00000432424.2	+	0	549							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						TGGGACTCTCTTTTTTCCCAA	0.363													3	3	---	---	---	---					
AC133680.1	0	broad.mit.edu	37	3	25007601	25007603	+	RNA	DEL	TTG	TTG	-	rs137918326	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:25007601_25007603delTTG	ENST00000455576.1	+	0	345																											TTTTTTTTTTTTGGTTATTTTAG	0.315													4	2	---	---	---	---					
LINC00693	645206	broad.mit.edu	37	3	28722769	28722769	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:28722769delG	ENST00000432518.2	+	0	809				LINC00693_ENST00000443912.1_RNA|LINC00693_ENST00000445077.1_RNA	NR_038840.1																						AAAAAAAAAAGAGGATCAGAG	0.353													2	4	---	---	---	---					
AC136289.1	0	broad.mit.edu	37	3	63794640	63794641	+	RNA	INS	-	-	T	rs142219338	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:63794640_63794641insT	ENST00000443346.1	-	0	622																											AATTAATGTGCTTTTTTTTTTC	0.431													2	4	---	---	---	---					
RP11-325B23.2	0	broad.mit.edu	37	3	98066005	98066005	+	RNA	DEL	G	G	-	rs9877169	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:98066005delG	ENST00000508616.1	+	0	188																											gtataaaaaagcagatgtaca	0.343													2	4	---	---	---	---					
RP11-325B23.2	0	broad.mit.edu	37	3	98167086	98167087	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:98167086_98167087insT	ENST00000508616.1	+	0	188																											cccgcctccccttttttttgga	0.495													2	4	---	---	---	---					
LINC00882	100302640	broad.mit.edu	37	3	106747064	106747064	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:106747064delC	ENST00000484698.1	-	0	337																											TTGTTTCCCTCCTCTAGTTTG	0.388													2	4	---	---	---	---					
RP11-572M11.4	0	broad.mit.edu	37	3	112854400	112854400	+	RNA	DEL	T	T	-	rs66679290		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:112854400delT	ENST00000496389.1	+	0	399																											AATGGTCATATTTTTTCCTTC	0.343													3	3	---	---	---	---					
RP11-384F7.1	0	broad.mit.edu	37	3	117769762	117769762	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:117769762delT	ENST00000482142.1	-	0	655																											ttcggtcgtgttttttttggt	0.308													2	4	---	---	---	---					
AADACL2-AS1	101928142	broad.mit.edu	37	3	151504748	151504749	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:151504748_151504749insA	ENST00000483843.2	-	0	439				RP11-454C18.2_ENST00000475855.1_RNA																							ttgttactaacaaaaactatac	0.347													2	4	---	---	---	---					
RP11-550I24.2	0	broad.mit.edu	37	3	156902568	156902568	+	RNA	DEL	T	T	-	rs79457921		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:156902568delT	ENST00000488040.1	+	0	43				RP11-550I24.2_ENST00000487238.1_RNA																							tcttcttttcttttttttttg	0.453													3	3	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177233703	177233705	+	RNA	DEL	AAC	AAC	-	rs72185566		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr3:177233703_177233705delAAC	ENST00000442937.1	+	0	190					NR_047568.1																						TAGTAATGATAACAATGATGATG	0.320													5	1	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14559293	14559294	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:14559293_14559294insT	ENST00000505089.1	-	0	461																											AGttttataaatttttttattc	0.337													2	4	---	---	---	---					
LOC101928851	101928851	broad.mit.edu	37	4	58311718	58311718	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:58311718delG	ENST00000510956.1	+	0	544																											CAGTAGGGCTGGCTTCGTTTT	0.443													2	4	---	---	---	---					
RP11-725D20.1	0	broad.mit.edu	37	4	60479096	60479096	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:60479096delA	ENST00000504537.1	-	0	114																											acaacaagtgaaaacaatgtg	0.269													2	4	---	---	---	---					
RP11-542G1.1	0	broad.mit.edu	37	4	76263298	76263298	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:76263298delA	ENST00000505930.1	-	0	41																											atgctatactaagaaacttgc	0.368													2	4	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105595926	105595927	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:105595926_105595927insT	ENST00000500179.1	+	0	733				RP11-556I14.2_ENST00000515127.1_lincRNA																							aacatctgtcattttttggcct	0.337													2	4	---	---	---	---					
RP11-659O3.1	0	broad.mit.edu	37	4	117028647	117028648	+	RNA	DEL	TG	TG	-	rs33917291		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:117028647_117028648delTG	ENST00000509983.1	-	0	333																											GAACAGATGTtgtgtgtgtgtg	0.386													2	4	---	---	---	---					
LINC01256	104355285	broad.mit.edu	37	4	133545714	133545715	+	RNA	INS	-	-	TAA	rs113095241		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:133545714_133545715insTAA	ENST00000513270.1	+	0	188																											ccttctcctccttctcctcctc	0.495													2	4	---	---	---	---					
RP11-284M14.1	0	broad.mit.edu	37	4	143972400	143972400	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:143972400delA	ENST00000507826.1	-	0	354																											CACAGAAAAGAAAAATGgcac	0.408													2	4	---	---	---	---					
RP11-164P12.4	0	broad.mit.edu	37	4	152588541	152588542	+	RNA	INS	-	-	C	rs1366910	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:152588541_152588542insC	ENST00000508664.1	+	0	92																											GTTGACTCTTTCCCCCCCTTCT	0.386													2	4	---	---	---	---					
LOC101928509	101928509	broad.mit.edu	37	4	175057640	175057640	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr4:175057640delG	ENST00000515444.1	-	0	85				RP11-248N22.1_ENST00000511346.1_lincRNA																							TTTTCAACTTGGAACTTTTAT	0.308													2	4	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9670204	9670205	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:9670204_9670205insA	ENST00000511616.1	-	0	1344					NR_027112.2																						cacagaaatacaaaaaaaccct	0.327													2	4	---	---	---	---					
RP11-124N3.3	0	broad.mit.edu	37	5	18968897	18968897	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:18968897delT	ENST00000504827.1	-	0	289																											cTGTACtttgtttttttttga	0.517													2	4	---	---	---	---					
CTD-2023N9.1	0	broad.mit.edu	37	5	56711474	56711474	+	RNA	DEL	C	C	-	rs5868053		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:56711474delC	ENST00000506106.1	+	0	119																											ACCCTCATAGCTTTTACTCAA	0.443													3	5	---	---	---	---					
LINC01331	104310351	broad.mit.edu	37	5	73724012	73724015	+	RNA	DEL	CAAA	CAAA	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:73724012_73724015delCAAA	ENST00000507781.1	-	0	422																											gactccgtctcaaacaaacaaaca	0.446													2	4	---	---	---	---					
RP11-6N13.1	0	broad.mit.edu	37	5	104667316	104667318	+	RNA	DEL	AGG	AGG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:104667316_104667318delAGG	ENST00000503650.1	-	0	210																											gagaaggagaaggaggaggagga	0.581													2	4	---	---	---	---					
STARD4-AS1	100505678	broad.mit.edu	37	5	110980395	110980396	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:110980395_110980396insA	ENST00000500779.2	+	0	283					NR_040093.1																						GTAGCAGTTGCAAAAACTGATT	0.322													2	4	---	---	---	---					
APC	324	broad.mit.edu	37	5	112175212	112175216	+	Frame_Shift_Del	DEL	AAAAG	AAAAG	-	rs121913224		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:112175212_112175216delAAAAG	ENST00000457016.1	+	16	4301_4305	c.3921_3925delAAAAG	c.(3919-3927)ataafs	p.IKE1307fs	APC_ENST00000508376.2_Frame_Shift_Del_p.IKE1307fs|APC_ENST00000257430.4_Frame_Shift_Del_p.IKE1307fs|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1307	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.		I -> K (in 6% of Ashkenazi Jews; associated with slightly increased risk of colon and breast cancer; dbSNP:rs1801155).		canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1309fs*6(51)|p.E1309fs*4(42)|p.E1309*(25)|p.I1307fs*6(12)|p.K1308*(6)|p.I1307fs*7(2)|p.I1311fs*4(2)|p.K1308fs*6(1)|p.I1307fs*13(1)|p.?(1)|p.E1309fs*5(1)|p.K1192fs*3(1)|p.?fs(1)|p.E1309K(1)|p.K1308E(1)|p.K1308fs*4(1)|p.I1307fs*14(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TAGCAGAAATAAAAGAAAAGATTGG	0.424		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			15	38	---	---	---	---					
CTC-575N7.1	0	broad.mit.edu	37	5	129161960	129161961	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:129161960_129161961insA	ENST00000503616.1	-	0	121				CTC-575N7.1_ENST00000515569.1_RNA																							gcagtggcaacaaaaacaaaaa	0.327													2	4	---	---	---	---					
CTC-255N20.1	0	broad.mit.edu	37	5	146589843	146589843	+	RNA	DEL	A	A	-	rs72094038		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:146589843delA	ENST00000504297.1	-	0	147																											CTTTATGGCTaaaaaaaaaaa	0.328													2	4	---	---	---	---					
LOC102546294	102546294	broad.mit.edu	37	5	147685319	147685320	+	RNA	DEL	TG	TG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:147685319_147685320delTG	ENST00000501695.3	-	0	591																											AGCTGGGAGCtgtgtgtgtgtg	0.455													3	4	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	163788130	163788131	+	RNA	INS	-	-	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:163788130_163788131insG	ENST00000486913.3	+	0	85				CTC-340A15.2_ENST00000524297.1_RNA|CTC-340A15.2_ENST00000523648.1_RNA|CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000523704.1_RNA|CTC-340A15.2_ENST00000517508.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000522686.1_RNA|CTC-340A15.2_ENST00000519329.1_RNA																							TCATTTGAGGAGGGGGGACTTT	0.356													2	4	---	---	---	---					
CTC-535M15.2	0	broad.mit.edu	37	5	164780258	164780259	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:164780258_164780259insT	ENST00000522189.1	+	0	21																											AGTCAACTTGATAGTGACGTTT	0.347													7	1	---	---	---	---					
CTC-535M15.2	0	broad.mit.edu	37	5	165106263	165106264	+	RNA	INS	-	-	T	rs72549517	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:165106263_165106264insT	ENST00000522189.1	+	0	21																											aAGAGGTACTCTTTTTTTTTCC	0.322													3	4	---	---	---	---					
CTD-2532K18.1	0	broad.mit.edu	37	5	174275132	174275133	+	RNA	INS	-	-	TTTG	rs57912892	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:174275132_174275133insTTTG	ENST00000502684.1	+	0	164																											GTCtttgtttttttgtttgttt	0.366													2	4	---	---	---	---					
RP11-443C10.1	0	broad.mit.edu	37	5	178804762	178804765	+	RNA	DEL	CATC	CATC	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr5:178804762_178804765delCATC	ENST00000519603.1	-	0	390_393				RP11-443C10.2_ENST00000520163.1_lincRNA																							CAGAGCTCAGCATCCAAACCAGTG	0.608													2	4	---	---	---	---					
RP11-532F6.4	0	broad.mit.edu	37	6	736946	736947	+	RNA	INS	-	-	G	rs114788612	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:736946_736947insG	ENST00000607644.1	+	0	243																											TCTTCTCTTCTGGGGGGTGGCC	0.574													2	4	---	---	---	---					
RP1-167F1.2	0	broad.mit.edu	37	6	19807958	19807959	+	RNA	INS	-	-	AG	rs111388601		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:19807958_19807959insAG	ENST00000432171.2	-	0	263																											caaaaaaaaaaaggggagagag	0.450													4	2	---	---	---	---					
LOC101929006	101929006	broad.mit.edu	37	6	29228332	29228332	+	RNA	DEL	C	C	-	rs144062472		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:29228332delC	ENST00000441381.1	+	0	79																											TGGTAGGTTACCCAAATATTG	0.413													3	3	---	---	---	---					
LOC101928516	101928516	broad.mit.edu	37	6	74849761	74849762	+	RNA	INS	-	-	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:74849761_74849762insG	ENST00000435946.1	+	0	138																											TGACCAATTTTGGGGGGAAGCA	0.475													2	4	---	---	---	---					
RP11-624M8.1	0	broad.mit.edu	37	6	125987549	125987550	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:125987549_125987550insA	ENST00000451660.2	-	0	443				RP11-624M8.1_ENST00000606334.1_RNA|RP11-624M8.1_ENST00000427852.2_RNA																							tgtatctctacaaaaaaagaaa	0.441													3	4	---	---	---	---					
LINC00271	100131814	broad.mit.edu	37	6	135992386	135992386	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:135992386delA	ENST00000421378.2	+	0	231					NR_026805.1																						ggatatcatcaaaaaaaaaaa	0.343													3	4	---	---	---	---					
RP11-631F7.2	0	broad.mit.edu	37	6	148457008	148457009	+	RNA	INS	-	-	A	rs71552995	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:148457008_148457009insA	ENST00000417838.1	-	0	96																											ccatctctaccaaaaaaaaaat	0.490													2	4	---	---	---	---					
LINC00473	90632	broad.mit.edu	37	6	166401465	166401466	+	RNA	DEL	GT	GT	-	rs71733419		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr6:166401465_166401466delGT	ENST00000584911.1	-	0	70_71																											gtgtgcgtgcgtgtgtgtgtgt	0.550													3	3	---	---	---	---					
LOC101927630	101927630	broad.mit.edu	37	7	17582560	17582569	+	RNA	DEL	ACACACACAC	ACACACACAC	-	rs72313277		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:17582560_17582569delACACACACAC	ENST00000451792.1	-	0	158																											CCTCAAATGTacacacacacacacacacac	0.395													2	4	---	---	---	---					
AC004869.2	0	broad.mit.edu	37	7	46518202	46518203	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:46518202_46518203insC	ENST00000440935.1	-	0	418																											GTCTAACACATCCCCCCAACCC	0.436													2	4	---	---	---	---					
TYW1B	441250	broad.mit.edu	37	7	72157791	72157791	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:72157791delG	ENST00000438125.1	-	0	1120							Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B (S. cerevisiae)						tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity										TCCAAAATCTGGGGAGACAGT	0.473													2	4	---	---	---	---					
COL26A1	136227	broad.mit.edu	37	7	101126481	101126481	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:101126481delT	ENST00000313669.7	+	0	577				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		AGAAATTAGCttttttttttt	0.463													2	4	---	---	---	---					
AC073130.3	0	broad.mit.edu	37	7	115902660	115902661	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:115902660_115902661insT	ENST00000444244.1	-	0	65				AC002066.1_ENST00000446355.2_RNA																							ttttttttttctttttcttttt	0.366													2	4	---	---	---	---					
AC009784.3	0	broad.mit.edu	37	7	135793838	135793839	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:135793838_135793839insC	ENST00000445293.2	+	0	112																											gtgtgtgatgacccccccaact	0.475													2	4	---	---	---	---					
C7orf13	129790	broad.mit.edu	37	7	156283174	156283174	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr7:156283174delA	ENST00000447933.1	-	0	300																											tctaaatgccaaaggaaaatc	0.343													2	4	---	---	---	---					
RP11-13N12.1	0	broad.mit.edu	37	8	16629680	16629680	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:16629680delA	ENST00000521411.2	-	0	373																											ATTCTCAAAGAAAAAAAAACA	0.383													2	4	---	---	---	---					
RP11-175E9.1	0	broad.mit.edu	37	8	23631110	23631110	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:23631110delT	ENST00000523874.1	+	0	75																											atctgaaggatttttttttgt	0.403													2	4	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36595158	36595159	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:36595158_36595159insA	ENST00000524132.1	-	0	411																											gactccgtcccaaaaaaaaaaa	0.436													2	4	---	---	---	---					
LOC101929268	101929268	broad.mit.edu	37	8	49468414	49468414	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:49468414delC	ENST00000522575.1	+	0	356				RP11-567J20.2_ENST00000524011.1_lincRNA																							gcttttttttcccccccaggt	0.448													2	4	---	---	---	---					
ZFHX4-AS1	100192378	broad.mit.edu	37	8	77546851	77546852	+	RNA	INS	-	-	A	rs141628118	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:77546851_77546852insA	ENST00000518143.1	-	0	434				ZFHX4-AS1_ENST00000522961.1_RNA	NR_024360.1																						agtaaaaccacatgagataaca	0.317													4	2	---	---	---	---					
RP13-923O23.6	0	broad.mit.edu	37	8	82705244	82705244	+	RNA	DEL	A	A	-	rs71268025		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:82705244delA	ENST00000524337.1	+	0	103																											CCCTTGAGGGAAAAAAATACC	0.289													4	2	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96423190	96423190	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:96423190delT	ENST00000521905.1	+	0	126																											ACAGAGTACCTTTTTCCCTTA	0.488													2	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96636047	96636048	+	RNA	DEL	AG	AG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:96636047_96636048delAG	ENST00000521905.1	+	0	320																											agcaggagcaagagagagagag	0.495													2	4	---	---	---	---					
LOC101927487	101927487	broad.mit.edu	37	8	112224423	112224423	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:112224423delC	ENST00000522778.1	-	0	122																											gacttggcctcccaaagtgct	0.393													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130478551	130478552	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:130478551_130478552insA	ENST00000446592.3	-	0	360																											TCCTTAAGAACAAAAAAACTCA	0.366													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130620937	130620937	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:130620937delC	ENST00000446592.3	-	0	312																											tatgtcctatccccccaaggg	0.527													2	4	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130621556	130621556	+	RNA	DEL	T	T	-	rs60793560		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr8:130621556delT	ENST00000446592.3	-	0	312																											cattaaattatttctatttct	0.338													3	4	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2535362	2535362	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:2535362delT	ENST00000416826.2	-	0	434																											TCAACCAAGATTTTGCATCTC	0.318													2	4	---	---	---	---					
MIR31HG	554202	broad.mit.edu	37	9	21490549	21490549	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:21490549delC	ENST00000304425.3	-	0	181					NR_027054.1																						ggggtagagacaaggagagaa	0.577													2	4	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68407616	68407616	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:68407616delA	ENST00000417843.2	-	0	67																											tggatcaagcagaagaaatag	0.343													3	6	---	---	---	---					
GGTA1P	2681	broad.mit.edu	37	9	124221741	124221742	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:124221741_124221742insA	ENST00000495328.1	-	0	684																											aaaatcaaatgaaaaaaaaGGA	0.455													2	4	---	---	---	---					
ABO	28	broad.mit.edu	37	9	136137176	136137176	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr9:136137176delG	ENST00000453660.2	-	0	110							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		TTCTGTGTCTGGAAGCGACTA	0.592													2	4	---	---	---	---					
RP11-556E13.1	0	broad.mit.edu	37	10	54346014	54346015	+	RNA	DEL	TG	TG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:54346014_54346015delTG	ENST00000443523.1	-	0	100																											ctctccattttgtgtgtgtgtg	0.302													2	4	---	---	---	---					
RP11-170M17.1	0	broad.mit.edu	37	10	65635544	65635545	+	RNA	INS	-	-	T	rs71028539		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:65635544_65635545insT	ENST00000444770.1	+	0	494																											accattctgtctttttttaaaa	0.361													2	4	---	---	---	---					
ZMIZ1-AS1	283050	broad.mit.edu	37	10	80732044	80732045	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:80732044_80732045insC	ENST00000456353.1	-	0	1012					NR_024431.2																						ccaactacctgcccccccgAAG	0.584													2	4	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125195451	125195452	+	RNA	DEL	CT	CT	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr10:125195451_125195452delCT	ENST00000448347.1	+	0	586																											gtttttcttcctctctctctct	0.535													2	4	---	---	---	---					
CTC-497E21.5	0	broad.mit.edu	37	11	13110241	13110242	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:13110241_13110242insA	ENST00000531136.1	-	0	47																											aaattttcaagaaaaaaaaaaa	0.366													4	2	---	---	---	---					
RP11-222N13.1	0	broad.mit.edu	37	11	15941432	15941432	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:15941432delG	ENST00000530418.1	+	0	217																											gattacaggtgcccaccacca	0.517													2	4	---	---	---	---					
RP11-266A24.1	0	broad.mit.edu	37	11	23213904	23213905	+	RNA	INS	-	-	AAGTATGGAAGAAGT	rs150194367	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:23213904_23213905insAAGTATGGAAGAAGT	ENST00000533591.1	+	0	476_477																											agatgaagaagaagtatggaag	0.347													5	3	---	---	---	---					
BDNF-AS	497258	broad.mit.edu	37	11	27579380	27579380	+	RNA	DEL	A	A	-	rs5790658		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:27579380delA	ENST00000499008.3	+	0	144				BDNF-AS_ENST00000501176.2_RNA|BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000532965.1_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000502161.2_RNA	NR_002832.2																						aaattactctaagagaaaatg	0.393													4	3	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	29051534	29051535	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:29051534_29051535insC	ENST00000513853.1	+	0	304																											TCCTCATTAGTCCCCCTGCCTA	0.366													2	4	---	---	---	---					
CTD-2572N17.1	0	broad.mit.edu	37	11	42241102	42241103	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:42241102_42241103insA	ENST00000527757.1	-	0	354																											aaagacacatcaaaaaaaaaaa	0.337													2	4	---	---	---	---					
OR4C5	79346	broad.mit.edu	37	11	48387945	48387946	+	Frame_Shift_Ins	INS	-	-	CA	rs114053360		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:48387945_48387946insCA	ENST00000319813.3	-	1	71_72	c.72_73insTG	c.(70-75)ttagcafs	p.LA24fs						olfactory receptor, family 4, subfamily C, member 5																		TTCACTTGCTCGAAATCCAGTT	0.366													4	7	---	---	---	---					
LOC100506368	100506368	broad.mit.edu	37	11	86692271	86692271	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:86692271delC	ENST00000499504.3	+	0	139					NR_038905.1																						TGTTTCTTTTCCCCAGCACCA	0.532													2	4	---	---	---	---					
RP11-94P11.4	0	broad.mit.edu	37	11	105352019	105352019	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:105352019delG	ENST00000528811.1	-	0	96																											catgagatttgggagaagaca	0.448													2	4	---	---	---	---					
RP11-262A12.1	0	broad.mit.edu	37	11	109673839	109673840	+	RNA	DEL	AA	AA	-	rs146084802		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:109673839_109673840delAA	ENST00000534252.2	-	0	393																											gacaaagcagaaaaaaaaaaaa	0.401													4	2	---	---	---	---					
AP000797.3	0	broad.mit.edu	37	11	115611339	115611339	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr11:115611339delT	ENST00000539305.1	+	0	163																											AGAATAGGACTTTTTTTTCTA	0.388													2	4	---	---	---	---					
LINC00937	389634	broad.mit.edu	37	12	8475132	8475132	+	RNA	DEL	T	T	-	rs34773514		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:8475132delT	ENST00000544461.1	-	0	1081				RP11-90D4.3_ENST00000535746.1_lincRNA|RP11-113C12.4_ENST00000537764.1_RNA																							gaagtgtttcttttttttttt	0.363													3	3	---	---	---	---					
RP11-415I12.3	0	broad.mit.edu	37	12	64128049	64128050	+	RNA	DEL	TG	TG	-	rs10615637		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:64128049_64128050delTG	ENST00000509615.2	-	0	238																											ATTATATATAtgtgtgtgtgtg	0.371													2	4	---	---	---	---					
LOC100507065	100507065	broad.mit.edu	37	12	65999609	65999611	+	RNA	DEL	TAT	TAT	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:65999609_65999611delTAT	ENST00000546198.1	-	0	203				RP11-221N13.3_ENST00000541391.1_lincRNA																							taggtattagtattattattatt	0.340													2	4	---	---	---	---					
IFNG-AS1	100885789	broad.mit.edu	37	12	68591955	68591960	+	RNA	DEL	TTGTTG	TTGTTG	-	rs3052116		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:68591955_68591960delTTGTTG	ENST00000536914.1	+	0	336																											GCTTTTGAGTttgttgttgttgttgt	0.427													2	4	---	---	---	---					
LOC101928002	101928002	broad.mit.edu	37	12	70119607	70119608	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:70119607_70119608insT	ENST00000501387.1	-	0	415				RP11-588G21.2_ENST00000501300.1_RNA																							tctactaaaaatacaaaatatt	0.510													2	4	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	75966755	75966756	+	RNA	DEL	GT	GT	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:75966755_75966756delGT	ENST00000552856.1	-	0	549																											gcatctgtgcgtgtgtgtgtgt	0.446													4	9	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76029026	76029026	+	RNA	DEL	A	A	-	rs58638346		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:76029026delA	ENST00000552856.1	-	0	401																											AGGTCTCTGTAAAAAAAAAAA	0.368													2	4	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97436963	97436964	+	RNA	INS	-	-	T	rs34142915	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:97436963_97436964insT	ENST00000552238.1	+	0	39				RP11-397H6.1_ENST00000549896.1_lincRNA																							agattgcgccattgcactccag	0.460													2	4	---	---	---	---					
RP11-328J6.1	0	broad.mit.edu	37	12	103526102	103526126	+	RNA	DEL	CTGGGGTCCTGAAATGGCTCCCTAA	CTGGGGTCCTGAAATGGCTCCCTAA	-	rs111481333		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:103526102_103526126delCTGGGGTCCTGAAATGGCTCCCTAA	ENST00000548594.1	-	0	167				RP11-328J6.1_ENST00000548415.1_RNA																							cagggcttggctggggtcctgaaatggctccctaacatgggaaaa	0.489													3	6	---	---	---	---					
LOC101927592	101927592	broad.mit.edu	37	12	127535785	127535785	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:127535785delC	ENST00000512624.2	-	0	311																											gatgatctgtcactgtctccc	0.443													2	4	---	---	---	---					
LINC01257	116437	broad.mit.edu	37	12	131665968	131665968	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr12:131665968delA	ENST00000376678.2	+	0	220					NR_026670.2																						ataatataacaaaaaaagaaa	0.323													2	4	---	---	---	---					
PDX1-AS1	100861550	broad.mit.edu	37	13	28409374	28409374	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:28409374delA	ENST00000499662.2	-	0	770																											ccagtcatgtaaaagtgtagc	0.368													2	4	---	---	---	---					
LINC00371	647166	broad.mit.edu	37	13	51670717	51670717	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:51670717delA	ENST00000563710.1	-	0	147																											TACTATATACAATCATTTCAA	0.313													2	4	---	---	---	---					
RP11-538C21.1	0	broad.mit.edu	37	13	58787682	58787683	+	RNA	INS	-	-	T	rs5803869	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:58787682_58787683insT	ENST00000454780.2	-	0	669																											AAAGCATTAGGTTTTTTTTTTG	0.272													3	3	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	78953065	78953066	+	RNA	DEL	GG	GG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:78953065_78953066delGG	ENST00000607862.1	+	0	315				RNF219-AS1_ENST00000606803.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000605996.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000606376.1_RNA																							gtctatttatggattcattcca	0.297													2	4	---	---	---	---					
RP11-30L8.1	0	broad.mit.edu	37	13	86681329	86681330	+	RNA	INS	-	-	TATC	rs36056138	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:86681329_86681330insTATC	ENST00000445967.1	+	0	148																											atccatCACTTtatctatctat	0.307													3	3	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101571441	101571441	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr13:101571441delG	ENST00000457843.1	+	0	141					NR_047687.1																						tccataacgtggagtggagaa	0.254													2	4	---	---	---	---					
RP11-146E13.4	0	broad.mit.edu	37	14	19818287	19818287	+	RNA	DEL	C	C	-	rs111887361		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:19818287delC	ENST00000548109.1	+	0	72																											gcatgagacacgcaccaccac	0.453													3	3	---	---	---	---					
RP11-244H18.3	0	broad.mit.edu	37	14	20108320	20108320	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:20108320delG	ENST00000551144.1	+	0	616				RP11-597A11.1_ENST00000548261.1_RNA																							TTAAGATTAAGGGGAAAAAAA	0.338													2	4	---	---	---	---					
RP11-384J4.2	0	broad.mit.edu	37	14	27454059	27454059	+	RNA	DEL	A	A	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:27454059delA	ENST00000552303.1	+	0	205																											CTCAAATTATAAAAAAGCTAT	0.308													2	4	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	28054971	28054972	+	RNA	DEL	TA	TA	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:28054971_28054972delTA	ENST00000553392.1	-	0	262																											tacatgcaggtatatatataca	0.282													2	4	---	---	---	---					
RP11-129M6.1	0	broad.mit.edu	37	14	41436438	41436441	+	RNA	DEL	AAAC	AAAC	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:41436438_41436441delAAAC	ENST00000515218.2	+	0	108																											gtctccaagaaaacaaacaaacaa	0.451													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44650325	44650325	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:44650325delT	ENST00000553827.1	-	0	69																											AAAATGTTACTTTTTTTTTCC	0.358													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44706419	44706420	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:44706419_44706420insC	ENST00000553827.1	-	0	69																											tcctgaggcctccccagtcatg	0.441													2	4	---	---	---	---					
CTD-2277K2.1	0	broad.mit.edu	37	14	62384402	62384402	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:62384402delT	ENST00000554436.1	+	0	482																											tgagttggacttttttttgtc	0.323													2	4	---	---	---	---					
RP11-1152H15.1	0	broad.mit.edu	37	14	88180073	88180074	+	RNA	DEL	AC	AC	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:88180073_88180074delAC	ENST00000554305.1	-	0	454																											acacacacagacacacacacac	0.391													3	5	---	---	---	---					
LOC100129345	100129345	broad.mit.edu	37	14	98114359	98114360	+	RNA	DEL	AG	AG	-	rs1756606		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr14:98114359_98114360delAG	ENST00000355909.3	-	0	414					NR_033943.1																						acagacacacagacacacacac	0.371													3	4	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	35879914	35879915	+	RNA	DEL	TG	TG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:35879914_35879915delTG	ENST00000501169.2	+	0	279					NR_038251.1																						ATTGTGAGCATGTGTGTGTGTG	0.406													2	4	---	---	---	---					
DPH6-AS1	100507466	broad.mit.edu	37	15	36044558	36044558	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:36044558delC	ENST00000501169.2	+	0	462					NR_038251.1																						ctccctccctcccttcctccc	0.532													2	4	---	---	---	---					
RP11-1129I3.1	0	broad.mit.edu	37	15	56852469	56852469	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:56852469delT	ENST00000562300.1	-	0	439																											catttctttcttttttttttc	0.448													3	6	---	---	---	---					
LINC01314	100996492	broad.mit.edu	37	15	80531591	80531591	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:80531591delC	ENST00000560778.2	-	0	207																											GTCTCTTGCTCCCCACCTCTC	0.537													2	4	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94593766	94593766	+	RNA	DEL	A	A	-	rs5814631		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:94593766delA	ENST00000558874.1	-	0	1141																											atcaaaaggcaaaaaaaaaaa	0.333													4	2	---	---	---	---					
LOC101927286	101927286	broad.mit.edu	37	15	97947065	97947065	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:97947065delT	ENST00000558621.1	-	0	302				CTD-2147F2.1_ENST00000560314.1_lincRNA																							ctttccttcctttttttttct	0.323													4	5	---	---	---	---					
CTD-2544M6.1	0	broad.mit.edu	37	15	98793769	98793770	+	RNA	INS	-	-	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:98793769_98793770insG	ENST00000560360.1	-	0	291																											ACAGAGTGTTTGGGGGGATGGG	0.381													2	4	---	---	---	---					
RP11-654A16.3	0	broad.mit.edu	37	15	99588529	99588530	+	RNA	DEL	TT	TT	-	rs71653354		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr15:99588529_99588530delTT	ENST00000559468.1	-	0	266																											ttacatgtaatttttttttttt	0.510													5	1	---	---	---	---					
U91319.1	0	broad.mit.edu	37	16	13396957	13396958	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:13396957_13396958insT	ENST00000571619.1	+	0	178																											GGCAATAACTGTTTTTTGCCCA	0.376													2	4	---	---	---	---					
AC004125.3	0	broad.mit.edu	37	16	24256943	24256944	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:24256943_24256944insT	ENST00000567624.1	+	0	52																											gaccatttctgtttttcaacaa	0.421													2	4	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32094264	32094264	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:32094264delT	ENST00000566806.1	-	0	499																											gtgggtatcatgaaaattatg	0.443													3	3	---	---	---	---					
AC012322.1	0	broad.mit.edu	37	16	64353235	64353236	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:64353235_64353236insA	ENST00000561657.1	-	0	381																											atgggtgtgctaaaaaagcagc	0.327													2	4	---	---	---	---					
AC012322.1	0	broad.mit.edu	37	16	64375381	64375388	+	RNA	DEL	TTCCTTCC	TTCCTTCC	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:64375381_64375388delTTCCTTCC	ENST00000561657.1	-	0	381																											TCTTTTCCTTttccttccttccttcctt	0.462													3	5	---	---	---	---					
RP11-351A20.1	0	broad.mit.edu	37	16	65658696	65658697	+	RNA	DEL	TT	TT	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:65658696_65658697delTT	ENST00000563811.1	+	0	167																											TTCCTGAATCTTAAGCTAGGAA	0.446													5	9	---	---	---	---					
LINC01572	101927957	broad.mit.edu	37	16	72615727	72615727	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr16:72615727delC	ENST00000561611.2	-	0	113																											ggggaaaaaacagagcagaaa	0.433													3	3	---	---	---	---					
FLJ36000	284124	broad.mit.edu	37	17	21911109	21911109	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:21911109delC	ENST00000581223.2	+	0	1834					NR_027084.1																						agaagtcgtgcccccgtgatc	0.617													2	4	---	---	---	---					
YWHAEP7	284100	broad.mit.edu	37	17	36237852	36237853	+	RNA	INS	-	-	AAC	rs56934604	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:36237852_36237853insAAC	ENST00000590732.1	-	0	108					NR_024178.1																						ccctgtctcaaaacaacaacaa	0.441													2	4	---	---	---	---					
CNTNAP1	8506	broad.mit.edu	37	17	40843872	40843873	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr17:40843872_40843873insC	ENST00000264638.4	+	16	2610_2611	c.2393_2394insC	c.(2392-2394)tccfs	p.S798fs	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	798					axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		GCACTACGCTTCCCCCCAATCC	0.564													7	439	---	---	---	---					
RP11-78F17.1	0	broad.mit.edu	37	18	1059390	1059390	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:1059390delC	ENST00000580781.1	+	0	306																											tatagccatacctgctttctt	0.348													2	4	---	---	---	---					
RP11-172F10.1	0	broad.mit.edu	37	18	4935838	4935839	+	RNA	INS	-	-	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:4935838_4935839insG	ENST00000584204.1	-	0	500																											acagcttttttgggggttctct	0.361													2	4	---	---	---	---					
RP11-172F10.1	0	broad.mit.edu	37	18	4939799	4939800	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:4939799_4939800insT	ENST00000584204.1	-	0	500																											ATACATGCTGATTTTTTCCTTG	0.322													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37364370	37364370	+	RNA	DEL	C	C	-	rs77471540		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:37364370delC	ENST00000591629.1	-	0	250					NR_024391.1																						CCCATCCCTACCCCCAATCTA	0.458													4	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	40024010	40024010	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:40024010delC	ENST00000593234.1	+	0	713					NR_046456.1																						GACCTTTATACCACCTTAATT	0.378													2	4	---	---	---	---					
LOC643542	643542	broad.mit.edu	37	18	65310673	65310674	+	RNA	DEL	TC	TC	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr18:65310673_65310674delTC	ENST00000583687.1	+	0	204					NR_033921.1																						tcctctcctttctctctctctc	0.554													2	4	---	---	---	---					
CTD-2043I16.1	0	broad.mit.edu	37	19	28573686	28573687	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:28573686_28573687insA	ENST00000590229.1	+	0	99																											atcatctgtagaaaaaaaaaga	0.307													2	4	---	---	---	---					
BBC3	27113	broad.mit.edu	37	19	47724978	47724978	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:47724978delC	ENST00000449228.1	-	4	929	c.766delG	c.(766-768)acfs	p.D256fs	BBC3_ENST00000300880.7_Frame_Shift_Del_p.D96fs|BBC3_ENST00000439096.2_3'UTR|BBC3_ENST00000341983.4_3'UTR	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		CAGAGAAAGTCCCCCGCGCTG	0.711													2	4	---	---	---	---					
MGC45922	284365	broad.mit.edu	37	19	51320945	51320946	+	RNA	DEL	TC	TC	-	rs137983112		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr19:51320945_51320946delTC	ENST00000326989.5	+	0	9_10					NR_038359.1																						CTGTGGGATGtctctctctccc	0.525													4	4	---	---	---	---					
LOC727993	727993	broad.mit.edu	37	20	1940244	1940245	+	RNA	INS	-	-	A	rs56954974		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:1940244_1940245insA	ENST00000446562.1	+	0	476																											aaaaaagactgaaaaaaaaaaa	0.322													2	4	---	---	---	---					
CASC20	101929244	broad.mit.edu	37	20	6446726	6446726	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:6446726delT	ENST00000415932.1	+	0	101																											attcacttccttttttttttt	0.438													3	5	---	---	---	---					
LOC101929371	101929371	broad.mit.edu	37	20	9980765	9980766	+	RNA	INS	-	-	C			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:9980765_9980766insC	ENST00000449270.1	+	0	432																											atggagagagacccccgagttt	0.559													2	4	---	---	---	---					
RP11-103J8.1	0	broad.mit.edu	37	20	10829666	10829666	+	RNA	DEL	A	A	-	rs76345738		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:10829666delA	ENST00000605292.1	+	0	98																											TAACTCCCCCACCCGCCTCCA	0.502													2	4	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29576719	29576719	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:29576719delT	ENST00000432067.1	-	0	288																											agttttaaagtttttttctga	0.254													2	4	---	---	---	---					
RP5-1121H13.4	0	broad.mit.edu	37	20	40655263	40655264	+	RNA	INS	-	-	G			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr20:40655263_40655264insG	ENST00000431589.1	+	0	131																											taggctctggtggggggcatga	0.545													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11045194	11045197	+	RNA	DEL	AGCC	AGCC	-	rs150583233		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:11045194_11045197delAGCC	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAGTTCTTATAGCCAGCCTAAAAG	0.314													6	1	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11094184	11094184	+	RNA	DEL	G	G	-	rs2775396		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:11094184delG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTTTTATAAAGATAACTACCT	0.393													2	4	---	---	---	---					
CHODL-AS1	54075	broad.mit.edu	37	21	19241215	19241216	+	RNA	INS	-	-	A	rs58694067	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:19241215_19241216insA	ENST00000447175.1	-	0	147					NR_024354.1																						ctttagaaattaaaaaaaaaGA	0.386													3	5	---	---	---	---					
CYYR1-AS1	100996571	broad.mit.edu	37	21	27774033	27774034	+	RNA	INS	-	-	T	rs35801633		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:27774033_27774034insT	ENST00000421771.1	+	0	130				AP001596.6_ENST00000429340.1_RNA|AP001596.6_ENST00000452460.1_RNA|AP001597.1_ENST00000414486.1_RNA																							taatgcggttgttttttttttt	0.332													3	4	---	---	---	---					
AP001607.1	0	broad.mit.edu	37	21	29015536	29015536	+	RNA	DEL	T	T	-	rs79704253		TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:29015536delT	ENST00000426418.1	+	0	231																											TTCCTTAGTATTTTTTTTTTC	0.294													3	4	---	---	---	---					
LOC284825	284825	broad.mit.edu	37	21	29481550	29481551	+	RNA	INS	-	-	ACTT	rs72478641	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr21:29481550_29481551insACTT	ENST00000426534.1	+	0	344																											GGGGATATGTCACACTTCATTT	0.317													2	4	---	---	---	---					
RP1-213J1P__B.1	0	broad.mit.edu	37	22	28093099	28093099	+	RNA	DEL	G	G	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr22:28093099delG	ENST00000440255.1	-	0	324																											CCACTGACTCGGGAATCTTGG	0.507													2	4	---	---	---	---					
RFPL1S	10740	broad.mit.edu	37	22	29872546	29872547	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr22:29872546_29872547insA	ENST00000461286.2	-	0	117				RFPL1S_ENST00000419368.1_RNA	NR_002727.2																						gtcctatggagaaaaaacaagc	0.431													2	4	---	---	---	---					
LINC01399	104310353	broad.mit.edu	37	22	35605322	35605323	+	RNA	DEL	GA	GA	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr22:35605322_35605323delGA	ENST00000423311.1	-	0	59																											gacagcaggcgagagagagaga	0.485													2	4	---	---	---	---					
RP1-293L6.1	0	broad.mit.edu	37	22	37107983	37107984	+	RNA	INS	-	-	G	rs35129062	by1000genomes	TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chr22:37107983_37107984insG	ENST00000430281.1	+	0	75																											aaatacaaaaaaaagaaagaaa	0.421													8	1	---	---	---	---					
MID1	4281	broad.mit.edu	37	X	11117938	11117938	+	RNA	DEL	C	C	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:11117938delC	ENST00000433747.2	-	0	322																											ATCTCTTTGTCCCCTTTGGCC	0.428													2	4	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50150474	50150475	+	RNA	DEL	AG	AG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:50150474_50150475delAG	ENST00000376025.2	-	0	1002							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					gtgtgcatgcagagagagagag	0.446													3	6	---	---	---	---					
DIAPH2-AS1	10824	broad.mit.edu	37	X	96865667	96865668	+	RNA	DEL	TG	TG	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:96865667_96865668delTG	ENST00000445414.1	-	0	148				DIAPH2-AS1_ENST00000542084.1_RNA																							AGTGTGCAGATGTGTGTGTGTG	0.450													2	4	---	---	---	---					
LINC00630	100287765	broad.mit.edu	37	X	102050301	102050301	+	RNA	DEL	T	T	-			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:102050301delT	ENST00000440496.1	+	0	232					NR_038988.1																						agtctatgtcttttaattggc	0.388													2	4	---	---	---	---					
RP5-964N17.1	0	broad.mit.edu	37	X	113013382	113013383	+	RNA	INS	-	-	T			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:113013382_113013383insT	ENST00000468762.2	-	0	26																											GTAGGGGAGTATTTTTTTTATA	0.337													2	4	---	---	---	---					
RP11-366F6.2	0	broad.mit.edu	37	X	151077017	151077018	+	RNA	INS	-	-	A			TCGA-17-Z007-01A-01W-0746-08	TCGA-17-Z007-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cac5bcd1-f044-4275-89cd-1110d0025537	cec1e6ce-89c1-43b3-b0e1-80654e13947d	g.chrX:151077017_151077018insA	ENST00000411474.1	-	0	433				RP11-366F6.2_ENST00000445330.1_RNA																							ggcattttcttaaaaaactgaa	0.332													2	4	---	---	---	---