Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1407	57577	broad.mit.edu	37	3	113724677	113724677	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:113724677C>T	ENST00000295878.3	-	10	1692	c.1546G>A	c.(1546-1548)Ggc>Agc	p.G516S	KIAA1407_ENST00000545063.1_Missense_Mutation_p.G347S	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	516										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						TGCTTATTGCCAGGTGCACTC	0.537000													36	120					0	0	0.069456	0	0
DMP1	1758	broad.mit.edu	37	4	88584103	88584103	+	Silent	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:88584103A>T	ENST00000339673.6	+	6	1272	c.1173A>T	c.(1171-1173)acA>acT	p.T391T	RP11-742B18.1_ENST00000506480.1_RNA|RP11-742B18.1_ENST00000507894.1_RNA|DMP1_ENST00000282479.7_Silent_p.T375T	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	391					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GCTCGCACACACTCTCCCACT	0.547000													83	241					0	0	0.139131	0	0
NCOA5	57727	broad.mit.edu	37	20	44695759	44695759	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:44695759G>A	ENST00000290231.6	-	5	728	c.564C>T	c.(562-564)atC>atT	p.I188I		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	188					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				AGCGTCTCTGGATTTCCTCAA	0.443000													105	88					0	0	0.139131	0	0
IRX4	50805	broad.mit.edu	37	5	1879616	1879616	+	Splice_Site	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:1879616A>T	ENST00000505790.1	-	5	1193		c.e5+1		IRX4_ENST00000513692.1_Splice_Site|IRX4_ENST00000231357.2_Splice_Site|IRX4_ENST00000505938.1_Splice_Site	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4						heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		CTCCCAACCCACCTGCGTTCT	0.682000													3	7					0	0	0.115264	0	0
NAPEPLD	222236	broad.mit.edu	37	7	102760088	102760088	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:102760088C>T	ENST00000417955.1	-	3	1031	c.877G>A	c.(877-879)Gag>Aag	p.E293K	NAPEPLD_ENST00000341533.4_Missense_Mutation_p.E293K|NAPEPLD_ENST00000455523.2_Missense_Mutation_p.E366K|NAPEPLD_ENST00000465647.1_Missense_Mutation_p.E293K|NAPEPLD_ENST00000427257.1_Missense_Mutation_p.E293K			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	293					phospholipid catabolic process	membrane	metal ion binding			endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						TTTCCTATCTCTTCAAAAGCA	0.443000													10	78					0	0	0.058154	0	0
IGKV1D-16	28901	broad.mit.edu	37	2	90139484	90139484	+	RNA	SNP	C	C	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:90139484C>G	ENST00000492446.1	+	0	282																											CAAGGTTCAGCGGCAGTGGAT	0.498000													58	128					0	0	0.139131	0	0
APC	324	broad.mit.edu	37	5	112175324	112175324	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:112175324G>T	ENST00000457016.1	+	16	4413	c.4033G>T	c.(4033-4035)Gaa>Taa	p.E1345*	APC_ENST00000508376.2_Nonsense_Mutation_p.E1345*|APC_ENST00000257430.4_Nonsense_Mutation_p.E1345*|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1345	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.E1345*(3)|p.S1335fs*70(1)|p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TTTATCTTCAGAATCAGCCAG	0.478000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			33	31					5.91797e-21	8.35743e-21	0.050027	1	0
ARHGAP44	9912	broad.mit.edu	37	17	12823096	12823096	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:12823096C>G	ENST00000379672.5	+	6	712	c.412C>G	c.(412-414)Cag>Gag	p.Q138E	ARHGAP44_ENST00000262444.9_Missense_Mutation_p.Q138E|ARHGAP44_ENST00000340825.3_Missense_Mutation_p.Q138E	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	138	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						TATTCAAAAGCAGAGGAAACA	0.398000													9	39					0	0	0.058154	0	0
XG	7499	broad.mit.edu	37	X	2712625	2712625	+	Silent	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrX:2712625C>A	ENST00000426774.1	+	6	529	c.306C>A	c.(304-306)ccC>ccA	p.P102P	XG_ENST00000381174.5_Silent_p.P101P|XG_ENST00000419513.2_Silent_p.P101P	NM_001141920.1|NM_175569.2	NP_001135392.1|NP_780778.1	P55808	XG_HUMAN	Xg blood group	101						integral to membrane|plasma membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)	8		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CGCCCAGGCCCAGGCCACGGC	0.612000													11	5					1.08611e-07	1.26371e-07	0.080935	1	0
NCOA5	57727	broad.mit.edu	37	20	44698859	44698859	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:44698859G>A	ENST00000290231.6	-	3	519	c.355C>T	c.(355-357)Cct>Tct	p.P119S		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	119	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CTGTACATAGGATCTCGGGAG	0.413000													57	59					0	0	0.139131	0	0
MPDZ	8777	broad.mit.edu	37	9	13126768	13126768	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:13126768G>T	ENST00000319217.7	-	33	4715	c.4468C>A	c.(4468-4470)Cag>Aag	p.Q1490K	MPDZ_ENST00000538841.1_Missense_Mutation_p.Q349K|MPDZ_ENST00000541718.1_Missense_Mutation_p.Q1490K|MPDZ_ENST00000381015.4_Missense_Mutation_p.Q1490K|MPDZ_ENST00000541093.1_5'UTR|MPDZ_ENST00000381022.2_Missense_Mutation_p.Q1490K|MPDZ_ENST00000546205.1_Missense_Mutation_p.Q1504K|MPDZ_ENST00000536827.1_Missense_Mutation_p.Q1457K|MPDZ_ENST00000447879.1_Missense_Mutation_p.Q1457K	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1490	PDZ 9.				interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		AAACCCCCCTGATCCTAGAAA	0.398000													42	55					6.5261e-18	8.94318e-18	0.104719	1	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000404276.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	87					0	0	0.038147	0	0
UNC80	285175	broad.mit.edu	37	2	210783307	210783307	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:210783307C>T	ENST00000439458.1	+	32	5145	c.5065C>T	c.(5065-5067)Cca>Tca	p.P1689S	UNC80_ENST00000272845.5_Missense_Mutation_p.P1684S	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	1689						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						GCTTGGAATGCCATCCGTCCC	0.498000													14	27					0	0	0.132662	0	0
NDRG2	57447	broad.mit.edu	37	14	21487897	21487897	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:21487897T>A	ENST00000556147.1	-	10	1557	c.617A>T	c.(616-618)gAg>gTg	p.E206V	NDRG2_ENST00000397858.1_Missense_Mutation_p.E206V|NDRG2_ENST00000403829.3_Missense_Mutation_p.E202V|NDRG2_ENST00000360463.3_Missense_Mutation_p.E192V|NDRG2_ENST00000553503.1_Missense_Mutation_p.E192V|NDRG2_ENST00000397855.3_Missense_Mutation_p.E163V|NDRG2_ENST00000298687.5_Missense_Mutation_p.E206V|NDRG2_ENST00000555158.1_Missense_Mutation_p.E192V|NDRG2_ENST00000350792.3_Missense_Mutation_p.E192V|NDRG2_ENST00000554143.1_Missense_Mutation_p.E192V|NDRG2_ENST00000397847.2_Missense_Mutation_p.E206V|NDRG2_ENST00000554104.1_Missense_Mutation_p.E119V|NDRG2_ENST00000298684.5_Missense_Mutation_p.E163V|NDRG2_ENST00000397853.3_Missense_Mutation_p.E206V|NDRG2_ENST00000397844.2_Missense_Mutation_p.E192V|NDRG2_ENST00000397851.2_Missense_Mutation_p.E206V|NDRG2_ENST00000554277.1_5'UTR|NDRG2_ENST00000397856.3_Missense_Mutation_p.E192V			Q9UN36	NDRG2_HUMAN	NDRG family member 2	206					cell differentiation|nervous system development	centrosome|cytosol|Golgi apparatus|nucleus|perinuclear region of cytoplasm				breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	23	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TCCAGAGAGCTCTTCCTGAAG	0.398000													7	35					0	0	0.029380	0	0
CENPW	387103	broad.mit.edu	37	6	126661425	126661425	+	Silent	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:126661425G>T	ENST00000368328.4	+	1	106	c.6G>T	c.(4-6)gcG>gcT	p.A2A	CENPW_ENST00000368325.1_Silent_p.A2A|CENPW_ENST00000368326.1_Silent_p.A2A			Q5EE01	CENPW_HUMAN	centromere protein W	2						chromosome, centromeric region|nucleus	DNA binding			kidney(2)|large_intestine(1)|lung(3)	6						AGAGGATGGCGCTGTCGACCA	0.562000													37	69					1.76056e-25	2.54455e-25	0.124865	1	0
KANSL1L	151050	broad.mit.edu	37	2	211018966	211018966	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:211018966T>A	ENST00000281772.9	-	2	604	c.341A>T	c.(340-342)tAt>tTt	p.Y114F	KANSL1L_ENST00000429908.2_5'UTR|KANSL1L_ENST00000418791.1_Missense_Mutation_p.Y114F|KANSL1L_ENST00000452086.1_Missense_Mutation_p.Y114F|KANSL1L_ENST00000457374.1_Missense_Mutation_p.Y114F	NM_152519.2	NP_689732.2	A0AUZ9	CB067_HUMAN	KAT8 regulatory NSL complex subunit 1-like	114																	GCTGCCATTATACAGTATGTT	0.343000													13	27					0	0	0.132662	0	0
RABGGTA	5875	broad.mit.edu	37	14	24737810	24737810	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:24737810C>T	ENST00000399409.3	-	9	1399	c.916G>A	c.(916-918)Gct>Act	p.A306T	RABGGTA_ENST00000216840.6_Missense_Mutation_p.A306T|RABGGTA_ENST00000560777.1_Intron	NM_004581.5	NP_004572.3	Q92696	PGTA_HUMAN	Rab geranylgeranyltransferase, alpha subunit	306					visual perception		Rab geranylgeranyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)	12				GBM - Glioblastoma multiforme(265;0.0184)		AGGGAGGCAGCAGGCAGGTCA	0.542000													37	57					0	0	0.092188	0	0
MKL1	57591	broad.mit.edu	37	22	40819642	40819642	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:40819642G>A	ENST00000396617.3	-	9	1115	c.525C>T	c.(523-525)ttC>ttT	p.F175F	MKL1_ENST00000407029.1_Silent_p.F175F|MKL1_ENST00000355630.3_Silent_p.F175F|MKL1_ENST00000402042.1_Intron			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	175	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GCTCTGCCAGGAAAAGCATTT	0.582000			T	RBM15	acute megakaryocytic leukemia								20	67					0	0	0.062417	0	0
ZWINT	11130	broad.mit.edu	37	10	58118400	58118400	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr10:58118400C>T	ENST00000373944.3	-	7	747	c.709G>A	c.(709-711)Gat>Aat	p.D237N	ZWINT_ENST00000361148.6_Missense_Mutation_p.D190N|ZWINT_ENST00000395405.1_Missense_Mutation_p.D237N|ZWINT_ENST00000460654.1_5'UTR|ZWINT_ENST00000318387.2_Missense_Mutation_p.D117N			O95229	ZWINT_HUMAN	ZW10 interacting kinetochore protein	237					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)	20						GGTTTATCATCTGGAAGATTC	0.532000													24	30					0	0	0.083992	0	0
MARCH6	10299	broad.mit.edu	37	5	10426547	10426547	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:10426547C>T	ENST00000274140.5	+	24	2551	c.2419C>T	c.(2419-2421)Cgt>Tgt	p.R807C	MARCH6_ENST00000449913.2_Missense_Mutation_p.R759C|MARCH6_ENST00000510792.1_Missense_Mutation_p.R505C|MARCH6_ENST00000503788.1_Missense_Mutation_p.R702C	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	807					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						CTATATTGTTCGTAAACTGGC	0.413000													84	424					0	0	0.139131	0	0
DUSP27	92235	broad.mit.edu	37	1	167096077	167096077	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:167096077C>A	ENST00000361200.2	+	6	1875	c.1709C>A	c.(1708-1710)cCc>cAc	p.P570H	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.P570H|DUSP27_ENST00000443333.1_Missense_Mutation_p.P570H			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	570					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGCGGTGAGCCCGGTGCAGAG	0.552000													28	72					1.5548e-18	2.14655e-18	0.108266	1	0
LOXHD1	125336	broad.mit.edu	37	18	44109192	44109192	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:44109192T>A	ENST00000536736.1	-	29	4477	c.4478A>T	c.(4477-4479)gAg>gTg	p.E1493V	LOXHD1_ENST00000441893.2_Missense_Mutation_p.E426V|LOXHD1_ENST00000441551.2_Missense_Mutation_p.E1287V|LOXHD1_ENST00000579038.1_Missense_Mutation_p.E286V|LOXHD1_ENST00000300591.6_Missense_Mutation_p.E382V|LOXHD1_ENST00000398722.4_Missense_Mutation_p.E1215V|LOXHD1_ENST00000582408.1_Missense_Mutation_p.E382V	NM_144612.6	NP_653213.6	Q8IVV2	LOXH1_HUMAN	lipoxygenase homology domains 1	1215	PLAT 11.				sensory perception of sound	stereocilium	protein binding			NS(3)|autonomic_ganglia(1)|breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(2)|pancreas(1)|prostate(4)|skin(4)|stomach(1)	36						AAGGTATCGCTCCCCAGTGTC	0.577000													6	12					0	0	0.038147	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					4	90					0	0	0.029380	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6285	6285	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrM:6285G>A	ENST00000361624.2	+	1	382	c.382G>A	c.(382-384)Gtc>Atc	p.128_128insI						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						CAGGTTGAACAGTCTACCCTC	0.532000													631	1055					0	0	0.139131	0	0
ZC2HC1A	51101	broad.mit.edu	37	8	79609710	79609710	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:79609710G>A	ENST00000263849.4	+	6	675	c.573G>A	c.(571-573)ccG>ccA	p.P191P	ZC2HC1A_ENST00000521176.1_3'UTR	NM_016010.2	NP_057094.2	Q96GY0	F164A_HUMAN	zinc finger, C2HC-type containing 1A	191																	CACGATTACCGCAGCCAAGTG	0.383000													30	68					0	0	0.059317	0	0
CFHR1	3078	broad.mit.edu	37	1	196796124	196796124	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:196796124G>A	ENST00000320493.5	+	3	507	c.419G>A	c.(418-420)tGc>tAc	p.C140Y	CFHR1_ENST00000367424.3_Missense_Mutation_p.C140Y|CFHR1_ENST00000498248.1_3'UTR|CFHR2_ENST00000367421.3_Intron	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	140	Sushi 2.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						CCTCCCAAATGCAGGTCCACT	0.373000													5	166					0	0	0.021553	0	0
ANAPC7	51434	broad.mit.edu	37	12	110819628	110819628	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:110819628C>A	ENST00000455511.3	-	8	1163	c.1163G>T	c.(1162-1164)aGa>aTa	p.R388I	ANAPC7_ENST00000450008.2_Missense_Mutation_p.R388I	NM_016238.2	NP_057322.2	Q9UJX3	APC7_HUMAN	anaphase promoting complex subunit 7	388					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)	19						TTCTTGGACTCTGCCCATGTT	0.473000													3	35					0.115264	0.118466	0.115264	1	0
APBB2	323	broad.mit.edu	37	4	40832537	40832537	+	Silent	SNP	A	A	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:40832537A>G	ENST00000295974.8	-	13	2213	c.1584T>C	c.(1582-1584)ttT>ttC	p.F528F	APBB2_ENST00000508593.1_Silent_p.F529F|APBB2_ENST00000506352.1_Silent_p.F507F|APBB2_ENST00000502841.1_5'UTR|APBB2_ENST00000543538.1_5'UTR|APBB2_ENST00000513140.1_Silent_p.F507F|APBB2_ENST00000504305.1_5'UTR	NM_001166050.1|NM_004307.1	NP_001159522.1|NP_004298.1	Q92870	APBB2_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 2	528	PID 1.				cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						TGTCACATCGAAATACATGAC	0.428000													34	69					0	0	0.074837	0	0
GPR158	57512	broad.mit.edu	37	10	25885717	25885717	+	Splice_Site	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr10:25885717G>A	ENST00000376351.3	+	10	2503	c.2145_splice	c.e10+1	p.R715_splice	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	715						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GAGGACATTCGGGTAATGCCA	0.488000													24	48					0	0	0.125774	0	0
MIR4485	100616263	broad.mit.edu	37	MT	2652	2652	+	RNA	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrM:2652G>A	ENST00000387347.2	+	0	982					NR_039705.1																						cacgagggttcagctgtctct	0.463000													11	1655					0	0	0.021553	0	0
SLFN11	91607	broad.mit.edu	37	17	33690515	33690515	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:33690515G>T	ENST00000394566.1	-	4	584	c.312C>A	c.(310-312)taC>taA	p.Y104*	SLFN11_ENST00000308377.4_Nonsense_Mutation_p.Y104*	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	104						nucleus	ATP binding			autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TAACAAAAATGTAAAAACACC	0.448000													20	48					7.45023e-12	9.37613e-12	0.055883	1	0
CSMD3	114788	broad.mit.edu	37	8	113518959	113518959	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:113518959G>C	ENST00000297405.5	-	29	5100	c.4856C>G	c.(4855-4857)aCc>aGc	p.T1619S	CSMD3_ENST00000343508.3_Missense_Mutation_p.T1579S|CSMD3_ENST00000352409.3_Missense_Mutation_p.T1619S|CSMD3_ENST00000455883.2_Missense_Mutation_p.T1515S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1619	CUB 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGCATTGACGGTGATAGTCCA	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			43	108					0	0	0.139131	0	0
CHD5	26038	broad.mit.edu	37	1	6185838	6185838	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:6185838G>T	ENST00000262450.3	-	27	4258	c.4159C>A	c.(4159-4161)Ccg>Acg	p.P1387T	CHD5_ENST00000378021.1_Missense_Mutation_p.P244T	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1387					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		TGCCCTTCCGGCCTCTCTTCA	0.582000													43	95					2.24059e-37	3.31607e-37	0.139131	1	0
PPP4C	5531	broad.mit.edu	37	16	30094792	30094792	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:30094792C>T	ENST00000279387.7	+	6	549	c.381C>T	c.(379-381)taC>taT	p.Y127Y	PPP4C_ENST00000561610.1_Silent_p.Y127Y	NM_002720.1	NP_002711.1	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	127					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(2)|pancreas(1)|skin(1)|urinary_tract(1)	9						ATGGCTTCTACGATGAGTGCC	0.572000													11	56					0	0	0.080935	0	0
TPD52L2	7165	broad.mit.edu	37	20	62505074	62505074	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:62505074C>T	ENST00000217121.5	+	3	291	c.219C>T	c.(217-219)caC>caT	p.H73H	TPD52L2_ENST00000369927.4_Silent_p.H50H|TPD52L2_ENST00000352482.4_Silent_p.H73H|TPD52L2_ENST00000351424.4_Silent_p.H73H|TPD52L2_ENST00000358548.4_Silent_p.H73H|TPD52L2_ENST00000348257.5_Silent_p.H73H|TPD52L2_ENST00000346249.4_Silent_p.H73H	NM_199360.2	NP_955392.1	O43399	TPD54_HUMAN	tumor protein D52-like 2	73					regulation of cell proliferation	perinuclear region of cytoplasm	protein binding|protein homodimerization activity			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	8	all_cancers(38;1.3e-12)|all_epithelial(29;2.23e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					AGGAGAGGCACTGTGGAGAGC	0.582000													3	15					0	0	0.115264	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17939562	17939562	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:17939562G>C	ENST00000361221.3	+	8	778	c.619G>C	c.(619-621)Gac>Cac	p.D207H	ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.D207H|ARHGEF10L_ENST00000375420.3_Intron|ARHGEF10L_ENST00000452522.1_Intron|ARHGEF10L_ENST00000375415.1_Intron	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	207					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GCTTTCTCCAGACCTGACTAG	0.547000													23	38					0	0	0.108266	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21938055	21938055	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:21938055C>A	ENST00000542643.2	-	14	1035	c.733G>T	c.(733-735)Gtg>Ttg	p.V245L	RAP1GAP_ENST00000374761.2_Missense_Mutation_p.V276L|RAP1GAP_ENST00000374765.4_Missense_Mutation_p.V245L|RAP1GAP_ENST00000290101.4_Missense_Mutation_p.V309L|RAP1GAP_ENST00000374763.2_Missense_Mutation_p.V245L	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	245	Rap-GAP.				regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		CCGTGGGTCACGTCCAGGCCT	0.662000													23	26					2.44723e-14	3.21091e-14	0.099896	1	0
MYH9	4627	broad.mit.edu	37	22	36737457	36737457	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:36737457T>A	ENST00000216181.5	-	3	678	c.448A>T	c.(448-450)Atc>Ttc	p.I150F	MYH9_ENST00000401701.1_Missense_Mutation_p.I150F	NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	150	Myosin head-like.				actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						ATGGCATAGATGTGAGGGGGC	0.522000			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				27	71					0	0	0.108266	0	0
SCARF1	8578	broad.mit.edu	37	17	1543283	1543283	+	Silent	SNP	G	G	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:1543283G>C	ENST00000263071.4	-	6	1111	c.1062C>G	c.(1060-1062)acC>acG	p.T354T	SCARF1_ENST00000571272.1_Silent_p.T354T|SCARF1_ENST00000348987.3_Intron	NM_003693.2|NM_145350.1	NP_003684.2|NP_663325.1	Q14162	SREC_HUMAN	scavenger receptor class F, member 1	354	EGF-like 6.				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			cervix(1)|endometrium(3)|kidney(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		AGGTGGGGCAGGTAGAGCCAC	0.647000													7	16					0	0	0.038147	0	0
LARP4B	23185	broad.mit.edu	37	10	909732	909732	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr10:909732G>A	ENST00000316157.3	-	4	421	c.381C>T	c.(379-381)ctC>ctT	p.L127L		NM_015155.1	NP_055970.1	Q92615	LAR4B_HUMAN	La ribonucleoprotein domain family, member 4B	127							nucleotide binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	38						GACCCAGAGCGAGAGCGTTCA	0.507000													16	177					0	0	0.132662	0	0
PLS1	5357	broad.mit.edu	37	3	142402909	142402909	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:142402909G>T	ENST00000337777.3	+	7	854	c.641G>T	c.(640-642)gGt>gTt	p.G214V	PLS1_ENST00000497002.1_Missense_Mutation_p.G214V|PLS1_ENST00000457734.2_Missense_Mutation_p.G214V	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	214	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						GTCAACATTGGTGCATCAGAT	0.408000													39	94					2.59497e-14	3.38077e-14	0.098360	1	0
RBFOX1	54715	broad.mit.edu	37	16	7645633	7645633	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:7645633G>T	ENST00000340209.4	+	5	863	c.566G>T	c.(565-567)cGt>cTt	p.R189L	RBFOX1_ENST00000311745.5_Missense_Mutation_p.R204L|RBFOX1_ENST00000547372.1_Missense_Mutation_p.R227L|RBFOX1_ENST00000436368.2_Missense_Mutation_p.R204L|RBFOX1_ENST00000422070.4_Missense_Mutation_p.R227L|RBFOX1_ENST00000553186.1_Missense_Mutation_p.R184L|RBFOX1_ENST00000550418.1_Missense_Mutation_p.R184L|RBFOX1_ENST00000535565.2_Intron|RBFOX1_ENST00000547338.1_Missense_Mutation_p.R184L|RBFOX1_ENST00000552089.1_Missense_Mutation_p.R201L|RBFOX1_ENST00000355637.4_Missense_Mutation_p.R204L			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	184	RRM.				mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						GTAGAGGGCCGTAAAATCGAG	0.458000													50	95					5.22555e-25	7.49401e-25	0.139131	1	0
KRTAP9-2	83899	broad.mit.edu	37	17	39383275	39383275	+	Silent	SNP	C	C	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:39383275C>G	ENST00000377721.3	+	1	376	c.369C>G	c.(367-369)ccC>ccG	p.P123P	KRTAP9-2_ENST00000455970.2_Silent_p.P107P	NM_031961.2	NP_114167.2	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9-2	123	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding			large_intestine(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCTACTACCCCACGACTGTCT	0.627000													4	209					0	0	0.009096	0	0
COMMD10	51397	broad.mit.edu	37	5	115428253	115428253	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:115428253C>A	ENST00000274458.4	+	4	317	c.255C>A	c.(253-255)caC>caA	p.H85Q	COMMD10_ENST00000515539.1_Missense_Mutation_p.H71Q	NM_016144.2	NP_057228.1	Q9Y6G5	COMDA_HUMAN	COMM domain containing 10	85							protein binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(2)	9		all_cancers(142;0.0834)|all_epithelial(76;0.00314)|Prostate(80;0.0102)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;4.3e-07)|Epithelial(69;8.06e-07)|all cancers(49;4.06e-05)		CAGTGTATCACAATGTGAAGC	0.333000													26	30					9.39395e-14	1.20686e-13	0.116897	1	0
METTL14	57721	broad.mit.edu	37	4	119626964	119626964	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:119626964A>G	ENST00000388822.4	+	10	1221	c.1054A>G	c.(1054-1056)Aca>Gca	p.T352A	METTL14_ENST00000506780.1_Missense_Mutation_p.T314A			Q9HCE5	MTL14_HUMAN	methyltransferase like 14	352						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|stomach(1)	16						AAGAGATAGTACAATTCGACC	0.343000													32	62					0	0	0.050027	0	0
STS	412	broad.mit.edu	37	X	7177623	7177623	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrX:7177623G>T	ENST00000217961.4	+	5	851	c.631G>T	c.(631-633)Gtg>Ttg	p.V211L		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	211					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	GCTACTCCACGTGCCTCTAGG	0.552000									Ichthyosis				33	31					1.22384e-17	1.66478e-17	0.054565	1	0
ACTR3C	653857	broad.mit.edu	37	7	149983569	149983569	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:149983569G>T	ENST00000539352.1	-	5	609	c.358C>A	c.(358-360)Ccc>Acc	p.P120T	ACTR3C_ENST00000252071.4_Missense_Mutation_p.P120T	NM_001164458.1	NP_001157930.1	Q9C0K3	ARP3C_HUMAN	ARP3 actin-related protein 3 homolog C (yeast)	120					regulation of actin filament polymerization	cytoskeleton	actin binding|ATP binding										CACTTCTGGGGATCCACATCA	0.413000													25	50					1.64293e-13	2.09616e-13	0.083992	1	0
NMBR	4829	broad.mit.edu	37	6	142399730	142399730	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:142399730T>G	ENST00000258042.1	-	2	873	c.733A>C	c.(733-735)Aat>Cat	p.N245H		NM_002511.2	NP_002502.2	P28336	NMBR_HUMAN	neuromedin B receptor	245					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			breast(2)|central_nervous_system(3)|endometrium(3)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		CCAGGAAGATTGTGTGCGCTT	0.358000													18	18					0	0	0.043863	0	0
USB1	79650	broad.mit.edu	37	16	58043944	58043944	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:58043944G>T	ENST00000219281.3	+	3	488	c.377G>T	c.(376-378)aGt>aTt	p.S126I	USB1_ENST00000539737.2_Missense_Mutation_p.S126I|USB1_ENST00000561743.1_Missense_Mutation_p.S75I|USB1_ENST00000565662.1_3'UTR|USB1_ENST00000563149.1_Missense_Mutation_p.S126I|USB1_ENST00000423271.3_Missense_Mutation_p.S126I	NM_024598.3	NP_078874.2			U6 snRNA biogenesis 1																		CTGTCCCAGAGTGTGGTTCTG	0.582000													17	53					3.8784e-16	5.1619e-16	0.062417	1	0
MYH11	4629	broad.mit.edu	37	16	15850278	15850278	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:15850278G>C	ENST00000338282.6	-	14	1775	c.1669C>G	c.(1669-1671)Cag>Gag	p.Q557E	MYH11_ENST00000576790.1_Missense_Mutation_p.Q557E|MYH11_ENST00000300036.5_Missense_Mutation_p.Q557E|MYH11_ENST00000396324.3_Missense_Mutation_p.Q564E|MYH11_ENST00000452625.2_Missense_Mutation_p.Q564E	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	557	Myosin head-like.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle	p.Q557_S559delQGS(1)		NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TGGCTGCCCTGCTCCGTGCAC	0.587000			T	CBFB	AML						OREG0023636	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	19					0	0	0.069234	0	0
OR4C15	81309	broad.mit.edu	37	11	55322156	55322156	+	Missense_Mutation	SNP	G	G	T	rs150289014		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:55322156G>T	ENST00000314644.2	+	1	374	c.374G>T	c.(373-375)tGc>tTc	p.C125F		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						CTGGATGCGTGCTTCTCATCT	0.478000										HNSCC(20;0.049)			99	129					9.27813e-46	1.39549e-45	0.139131	1	0
POMC	5443	broad.mit.edu	37	2	25384268	25384268	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:25384268G>A	ENST00000405623.1	-	3	941	c.486C>T	c.(484-486)aaC>aaT	p.N162N	POMC_ENST00000380794.1_Silent_p.N162N|POMC_ENST00000264708.3_Silent_p.N162N|POMC_ENST00000395826.2_Silent_p.N162N			P01189	COLI_HUMAN	proopiomelanocortin	162					cell-cell signaling|cellular nitrogen compound metabolic process|cellular pigmentation|generation of precursor metabolites and energy|hormone biosynthetic process|negative regulation of tumor necrosis factor production|neuropeptide signaling pathway|peptide hormone processing|positive regulation of transcription from RNA polymerase II promoter|regulation of appetite|regulation of blood pressure	extracellular space|stored secretory granule	hormone activity|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)	12	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Hydrocortisone(DB00741)|Loperamide(DB00836)|Trilostane(DB01108)	CCTCGGCGCCGTTAGGGTACA	0.706000													5	15					0	0	0.029380	0	0
HCN1	348980	broad.mit.edu	37	5	45262664	45262664	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:45262664G>A	ENST00000303230.4	-	8	2089	c.2032C>T	c.(2032-2034)Ctg>Ttg	p.L678L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	678						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						GGGGAGTGCAGGTTGCTGTGA	0.617000													11	21					0	0	0.043863	0	0
MAGOHB	55110	broad.mit.edu	37	12	10763255	10763255	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:10763255C>T	ENST00000320756.2	-	2	209	c.119G>A	c.(118-120)aGc>aAc	p.S40N	MAGOHB_ENST00000539554.1_5'UTR|MAGOHB_ENST00000381881.2_Missense_Mutation_p.S40N	NM_018048.3	NP_060518.1	Q96A72	MGN2_HUMAN	mago-nashi homolog B (Drosophila)	40					mRNA processing|mRNA transport|RNA splicing	nucleus	RNA binding			breast(2)|large_intestine(2)	4						TTTGTAATTGCTGTTGTTGGC	0.269000													11	23					0	0	0.105934	0	0
ABCC9	10060	broad.mit.edu	37	12	22063913	22063913	+	Splice_Site	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:22063913C>T	ENST00000261200.4	-	7	1011		c.e7-1		ABCC9_ENST00000345162.2_Splice_Site|ABCC9_ENST00000261201.4_Splice_Site	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9						defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTCTGAAATCTGGTCCCCAA	0.333000													31	59					0	0	0.144211	0	0
RBBP6	5930	broad.mit.edu	37	16	24581297	24581297	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:24581297G>A	ENST00000319715.4	+	17	3718	c.3286G>A	c.(3286-3288)Gca>Aca	p.A1096T	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Missense_Mutation_p.A1062T	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1096	Interaction with RB1 (By similarity).				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		CTCTAAATCAGCAAAAGAACA	0.378000													3	43					0	0	0.115264	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482229	142482229	+	RNA	SNP	T	T	A	rs145494190	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:142482229T>A	ENST00000603901.1	+	0	609					NR_001296.3													p.P203P(1)									CTGGTGGCCCTGTGGTCTGCA	0.493000													4	89					0	0	0.047766	0	0
CDKL2	8999	broad.mit.edu	37	4	76525509	76525509	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:76525509C>T	ENST00000429927.2	-	7	1543	c.840G>A	c.(838-840)gaG>gaA	p.E280E	CDKL2_ENST00000307465.4_Silent_p.E280E	NM_003948.3	NP_003939.1	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2 (CDC2-related kinase)	280	Protein kinase.				sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(2)|stomach(2)	22			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			GGTGTAGGAGCTCAGCACAGA	0.373000													19	33					0	0	0.049695	0	0
ART5	116969	broad.mit.edu	37	11	3660107	3660107	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:3660107G>T	ENST00000397067.3	-	4	788	c.659C>A	c.(658-660)cCc>cAc	p.P220H	ART5_ENST00000359918.4_Intron|ART5_ENST00000397068.3_Intron			Q96L15	NAR5_HUMAN	ADP-ribosyltransferase 5	217						extracellular region	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(6)|ovary(1)	11		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0336)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTCCAGGGGGGCAGAGAGGA	0.612000													7	5					0.0293803	0.0305357	0.029380	1	0
MT-CO2	4513	broad.mit.edu	37	MT	7589	7589	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrM:7589G>A	ENST00000361739.1	+	1	4	c.4G>A	c.(4-6)Gca>Aca	p.A2T						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						ATATCTTAATGGCACATGCAG	0.373000													60	1213					0	0	0.069456	0	0
FAM27L	284123	broad.mit.edu	37	17	21825450	21825450	+	RNA	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:21825450G>T	ENST00000426869.3	+	0	154					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		cttctccacggggtacacagg	0.627000													9	18					2.17888e-05	2.48822e-05	0.058154	1	0
NACA	4666	broad.mit.edu	37	12	57114590	57114590	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:57114590C>T	ENST00000454682.1	-	3	1005	c.724G>A	c.(724-726)Gct>Act	p.A242T	NACA_ENST00000356769.3_Intron|NACA_ENST00000550952.1_Missense_Mutation_p.A242T|NACA_ENST00000393891.4_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000546392.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	17					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						TGAGGGGAAGCGATGGCTAGG	0.522000			T	BCL6	NHL								23	162					0	0	0.059317	0	0
FCGBP	8857	broad.mit.edu	37	19	40366230	40366230	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:40366230G>A	ENST00000221347.6	-	30	14011	c.14004C>T	c.(14002-14004)tgC>tgT	p.C4668C		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	4668	VWFD 11.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			AGATCACGCCGCAGGCGTCCG	0.721000													3	16					0	0	0.115264	0	0
HLTF	6596	broad.mit.edu	37	3	148802652	148802652	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:148802652C>A	ENST00000310053.5	-	2	238	c.45G>T	c.(43-45)caG>caT	p.Q15H	HLTF_ENST00000481663.1_5'UTR|HLTF_ENST00000392912.2_Missense_Mutation_p.Q15H|HLTF_ENST00000465259.1_Missense_Mutation_p.Q15H|HLTF_ENST00000494055.1_Missense_Mutation_p.Q15H	NM_003071.3|NM_139048.2	NP_003062.2|NP_620636.1	Q14527	HLTF_HUMAN	helicase-like transcription factor	15					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			ACTGGACAGTCTGCAAGTACT	0.348000													9	24					3.86212e-05	4.25293e-05	0.069234	1	0
RNF40	9810	broad.mit.edu	37	16	30779731	30779731	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:30779731C>G	ENST00000324685.6	+	13	2294	c.1859C>G	c.(1858-1860)cCc>cGc	p.P620R	RNF40_ENST00000563683.1_Missense_Mutation_p.P580R|RNF40_ENST00000357890.5_Missense_Mutation_p.P520R|RNF40_ENST00000402121.3_Missense_Mutation_p.P312R	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	620					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			CGGGAAGGTCCCAGCCTAGGA	0.627000													5	23					0	0	0.021553	0	0
CR2	1380	broad.mit.edu	37	1	207646299	207646299	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:207646299A>T	ENST00000367057.3	+	10	1942	c.1753A>T	c.(1753-1755)Acc>Tcc	p.T585S	CR2_ENST00000367058.3_Missense_Mutation_p.T585S|CR2_ENST00000367059.3_Missense_Mutation_p.T585S|CR2_ENST00000458541.2_Missense_Mutation_p.T558S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	585	Sushi 9.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AGAAAGAGGCACCTGGAGTGG	0.498000													21	44					0	0	0.076483	0	0
PLEC	5339	broad.mit.edu	37	8	144993686	144993686	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:144993686C>T	ENST00000322810.4	-	32	10883	c.10714G>A	c.(10714-10716)Ggc>Agc	p.G3572S	PLEC_ENST00000356346.3_Missense_Mutation_p.G3421S|PLEC_ENST00000436759.2_Missense_Mutation_p.G3462S|PLEC_ENST00000398774.2_Missense_Mutation_p.G3403S|PLEC_ENST00000354589.3_Missense_Mutation_p.G3435S|PLEC_ENST00000354958.2_Missense_Mutation_p.G3413S|PLEC_ENST00000357649.2_Missense_Mutation_p.G3439S|PLEC_ENST00000527096.1_Missense_Mutation_p.G3458S|PLEC_ENST00000345136.3_Missense_Mutation_p.G3435S	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3572	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TCTCTGTAGCCGGTGACGGCC	0.677000													8	17					0	0	0.069234	0	0
CGN	57530	broad.mit.edu	37	1	151501959	151501959	+	Missense_Mutation	SNP	G	G	C	rs144821285		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:151501959G>C	ENST00000271636.7	+	11	2163	c.2030G>C	c.(2029-2031)cGg>cCg	p.R677P		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	671	Glu-rich.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GATCGAGGTCGGGAGCTGGAA	0.627000													9	20					0	0	0.058154	0	0
LOXHD1	125336	broad.mit.edu	37	18	44109193	44109193	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:44109193C>A	ENST00000536736.1	-	29	4476	c.4477G>T	c.(4477-4479)Gag>Tag	p.E1493*	LOXHD1_ENST00000441893.2_Nonsense_Mutation_p.E426*|LOXHD1_ENST00000441551.2_Nonsense_Mutation_p.E1287*|LOXHD1_ENST00000579038.1_Nonsense_Mutation_p.E286*|LOXHD1_ENST00000300591.6_Nonsense_Mutation_p.E382*|LOXHD1_ENST00000398722.4_Nonsense_Mutation_p.E1215*|LOXHD1_ENST00000582408.1_Nonsense_Mutation_p.E382*	NM_144612.6	NP_653213.6	Q8IVV2	LOXH1_HUMAN	lipoxygenase homology domains 1	1215	PLAT 11.				sensory perception of sound	stereocilium	protein binding			NS(3)|autonomic_ganglia(1)|breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(2)|pancreas(1)|prostate(4)|skin(4)|stomach(1)	36						AGGTATCGCTCCCCAGTGTCC	0.572000													6	13					1.06961e-07	1.2524e-07	0.038147	1	0
LINC01410	103352539	broad.mit.edu	37	9	66458381	66458381	+	RNA	SNP	C	C	T	rs4471150		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:66458381C>T	ENST00000424345.1	+	0	67																											AGGCGCTCGCCCGTGCCCCCG	0.741000													4	9					0	0	0.009096	0	0
HEATR3	55027	broad.mit.edu	37	16	50128703	50128703	+	Splice_Site	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:50128703A>T	ENST00000299192.7	+	12	1789	c.1599_splice	c.e12+1	p.Q533_splice	HEATR3_ENST00000564942.1_3'UTR|HEATR3_ENST00000285767.4_Splice_Site_p.Q447_splice	NM_182922.2	NP_891552.1	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	533							binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						AACATTTCCCAGGTAAGAGTT	0.308000													16	86					0	0	0.033300	0	0
USP50	373509	broad.mit.edu	37	15	50836842	50836842	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:50836842T>C	ENST00000532404.1	-	2	363	c.190A>G	c.(190-192)Agc>Ggc	p.S64G	USP50_ENST00000530218.1_Intron	NM_203494.4	NP_987090.2	E9PP86	E9PP86_HUMAN	ubiquitin specific peptidase 50	64					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|kidney(2)|large_intestine(4)|liver(1)|lung(5)	13				all cancers(107;0.000519)|GBM - Glioblastoma multiforme(94;0.00288)		GGCAAGATGCTGCAGAGACAC	0.542000													28	48					0	0	0.108266	0	0
MCM3	4172	broad.mit.edu	37	6	52132735	52132735	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:52132735C>A	ENST00000596288.1	-	14	2162	c.2135G>T	c.(2134-2136)cGa>cTa	p.R712L	MCM3_ENST00000229854.7_Missense_Mutation_p.R667L|MCM3_ENST00000419835.2_Missense_Mutation_p.R621L	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	667					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					atcctcacttcgcttcttacg	0.498000													21	7					2.4624e-09	2.97741e-09	0.049695	1	0
SPTY2D1	144108	broad.mit.edu	37	11	18637460	18637460	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:18637460G>A	ENST00000336349.5	-	3	596	c.361C>T	c.(361-363)Cga>Tga	p.R121*	SPTY2D1_ENST00000543776.1_5'UTR	NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	121								p.R121R(1)		breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						TCATACTCTCGGTCGGTTCCT	0.448000													24	24					0	0	0.108266	0	0
POLDIP3	84271	broad.mit.edu	37	22	42988052	42988052	+	Silent	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:42988052T>A	ENST00000252115.5	-	7	1034	c.930A>T	c.(928-930)cgA>cgT	p.R310R	POLDIP3_ENST00000348657.2_Silent_p.R281R|POLDIP3_ENST00000451060.2_Silent_p.R154R|POLDIP3_ENST00000491021.1_5'UTR|POLDIP3_ENST00000339677.6_Intron	NM_032311.3	NP_115687.2	Q9BY77	PDIP3_HUMAN	polymerase (DNA-directed), delta interacting protein 3	310	RRM.				positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|upper_aerodigestive_tract(1)	16						GATGGACCAGTCGAGCTCGCT	0.542000													42	89					0	0	0.124865	0	0
NCOA5	57727	broad.mit.edu	37	20	44698943	44698943	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:44698943G>A	ENST00000290231.6	-	3	435	c.271C>T	c.(271-273)Cgt>Tgt	p.R91C		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	91	Arg/Asp-rich (mixed charge).|Transcription repression.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				CTTAGATCACGAAAGTCTCTA	0.512000													112	111					0	0	0.139131	0	0
BTK	695	broad.mit.edu	37	X	100609683	100609683	+	Splice_Site	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrX:100609683C>A	ENST00000308731.7	-	16	1730		c.e16-1		BTK_ENST00000372880.1_Splice_Site	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase						calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTCGAGCTGCCTGTAGTGCAA	0.483000									Agammaglobulinemia, X-linked				68	30					9.21137e-24	1.31085e-23	0.139131	1	0
SV2B	9899	broad.mit.edu	37	15	91769847	91769847	+	Silent	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:91769847C>A	ENST00000394232.1	+	2	824	c.354C>A	c.(352-354)gcC>gcA	p.A118A	SV2B_ENST00000545111.2_Intron|SV2B_ENST00000557291.1_Intron|SV2B_ENST00000330276.4_Silent_p.A118A	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	118					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			TGGGTTTGGCCCTGATGGCCG	0.537000													18	47					2.94398e-08	3.51379e-08	0.043863	1	0
TSIX	9383	broad.mit.edu	37	X	73042835	73042835	+	RNA	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrX:73042835A>T	ENST00000604411.1	+	0	30796				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						ACTTAAGAACAGCACTTTATT	0.313000													13	24					0	0	0.093190	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052051	9052051	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:9052051C>A	ENST00000382496.5	-	20	3444	c.2779G>T	c.(2779-2781)Ggc>Tgc	p.G927C		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	927	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CACTGGCTGCCCATGGGGAAC	0.567000													6	16					0.0215528	0.0225269	0.021553	1	0
PTPN11	5781	broad.mit.edu	37	12	112926888	112926888	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:112926888G>T	ENST00000351677.2	+	13	1706	c.1508G>T	c.(1507-1509)gGg>gTg	p.G503V		NM_002834.3	NP_002825.3	Q06124	PTN11_HUMAN	protein tyrosine phosphatase, non-receptor type 11	507	Tyrosine-protein phosphatase.				axon guidance|cell junction assembly|ephrin receptor signaling pathway|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|platelet activation|regulation of cell adhesion mediated by integrin|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol	non-membrane spanning protein tyrosine phosphatase activity|protein binding	p.G503A(12)|p.G503V(8)|p.G503E(2)|p.G503L(1)		NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(406)|kidney(2)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(3)|stomach(3)	451						CAGAGGTCAGGGATGGTCCAG	0.468000			Mis		"""JMML, AML, MDS"""		Noonan Syndrome		Noonan syndrome				149	314					5.54423e-67	8.40723e-67	0.139131	1	0
SV2B	9899	broad.mit.edu	37	15	91769848	91769848	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:91769848C>A	ENST00000394232.1	+	2	825	c.355C>A	c.(355-357)Ctg>Atg	p.L119M	SV2B_ENST00000545111.2_Intron|SV2B_ENST00000557291.1_Intron|SV2B_ENST00000330276.4_Missense_Mutation_p.L119M	NM_014848.4	NP_055663.1	Q7L1I2	SV2B_HUMAN	synaptic vesicle glycoprotein 2B	119					neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(17)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GGGTTTGGCCCTGATGGCCGA	0.537000													19	47					4.96729e-08	5.8907e-08	0.049695	1	0
NCOA5	57727	broad.mit.edu	37	20	44695708	44695708	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:44695708G>A	ENST00000290231.6	-	5	779	c.615C>T	c.(613-615)gtC>gtT	p.V205V		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				TCTGTTTGTTGACCACAATCA	0.438000													108	75					0	0	0.139131	0	0
HOOK1	51361	broad.mit.edu	37	1	60314856	60314856	+	Splice_Site	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:60314856G>T	ENST00000371208.3	+	12	1499		c.e12+1		HOOK1_ENST00000395561.2_Splice_Site|HOOK1_ENST00000465876.1_Splice_Site	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1						early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					GGAAAAAGAGGTAAACATAGA	0.358000													15	32					0.000219431	0.000240206	0.119110	1	0
FAM182A	284800	broad.mit.edu	37	20	26063993	26063993	+	RNA	SNP	A	A	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:26063993A>G	ENST00000376398.2	+	0	1510					NR_026713.1															breast(1)|endometrium(2)|kidney(1)	4						CTGAGACTTGATGTTTAATAT	0.557000													2	3					0	0	0.014758	0	0
LGALS9B	284194	broad.mit.edu	37	17	20361549	20361549	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:20361549G>T	ENST00000423676.3	-	3	343	c.280C>A	c.(280-282)Cag>Aag	p.Q94K	LGALS9B_ENST00000324290.5_Missense_Mutation_p.Q94K			Q3B8N2	LEG9B_HUMAN	lectin, galactoside-binding, soluble, 9B	94	Galectin 1.						sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	10						ATCCCCTTCTGGAAGGGCATG	0.587000													14	74					2.21704e-12	2.80926e-12	0.076483	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85459116	85459116	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:85459116T>C	ENST00000393217.2	+	9	2529	c.2468T>C	c.(2467-2469)cTa>cCa	p.L823P		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	823										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CTTCAGTTTCTATCCCTTCGA	0.413000													34	92					0	0	0.064281	0	0
CLDN16	10686	broad.mit.edu	37	3	190122610	190122610	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:190122610T>C	ENST00000264734.2	+	3	735	c.487T>C	c.(487-489)Ttt>Ctt	p.F163L	CLDN16_ENST00000468220.1_3'UTR|CLDN16_ENST00000456423.1_Intron	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	163					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		TGGGTTTGGATTTCTCACCCT	0.473000													22	45					0	0	0.069288	0	0
HIST2H2BB	338391	broad.mit.edu	37	1	149375106	149375106	+	RNA	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:149375106G>A	ENST00000415338.1	-	0	1061																											CTTTACTATCGAAATGGCAAA	0.468000													6	141					0	0	0.029380	0	0
DLC1	10395	broad.mit.edu	37	8	12952701	12952701	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:12952701C>T	ENST00000276297.4	-	11	3630	c.3221G>A	c.(3220-3222)aGt>aAt	p.S1074N	DLC1_ENST00000510318.1_5'UTR|DLC1_ENST00000520226.1_Missense_Mutation_p.S563N|DLC1_ENST00000358919.2_Missense_Mutation_p.S637N|DLC1_ENST00000512044.2_Missense_Mutation_p.S671N	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	1074					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCCAAACACACTCCGGTCCTT	0.552000													30	54					0	0	0.144211	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463677	25463677	+	RNA	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:25463677C>A	ENST00000424208.1	+	0	2960				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						CCAGCCCTTCCTGGTGCCCTG	0.597000													6	17					3.59834e-05	3.98618e-05	0.021553	1	0
ZNF98	148198	broad.mit.edu	37	19	22586297	22586297	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:22586297C>T	ENST00000357774.5	-	2	169	c.48G>A	c.(46-48)agG>agA	p.R16R	ZNF98_ENST00000601553.1_Silent_p.R16R	NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	16	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R16S(2)		central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				AGGCCACATCCCTAAATGTCA	0.393000													26	35					0	0	0.108266	0	0
SETBP1	26040	broad.mit.edu	37	18	42532248	42532248	+	Silent	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:42532248A>T	ENST00000282030.5	+	4	3239	c.2943A>T	c.(2941-2943)ccA>ccT	p.P981P		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	981						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		ACGAGAATCCATATCCCAGCA	0.463000									Schinzel-Giedion syndrome				48	86					0	0	0.139131	0	0
CSGALNACT1	55790	broad.mit.edu	37	8	19362892	19362892	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:19362892T>C	ENST00000454498.2	-	4	1467	c.454A>G	c.(454-456)Act>Gct	p.T152A	CSGALNACT1_ENST00000311540.4_Missense_Mutation_p.T152A|CSGALNACT1_ENST00000522854.1_Missense_Mutation_p.T152A|CSGALNACT1_ENST00000544602.1_Missense_Mutation_p.T152A|CSGALNACT1_ENST00000332246.6_Missense_Mutation_p.T152A	NM_001130518.1	NP_001123990.1	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate N-acetylgalactosaminyltransferase 1	152					anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31				Colorectal(111;0.182)		TTCTGTAGAGTAAAGCTATCG	0.577000													30	52					0	0	0.144211	0	0
CLEC16A	23274	broad.mit.edu	37	16	11133665	11133665	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:11133665A>T	ENST00000409790.1	+	14	1822	c.1592A>T	c.(1591-1593)gAg>gTg	p.E531V	CLEC16A_ENST00000465491.1_3'UTR|CLEC16A_ENST00000409552.3_Missense_Mutation_p.E513V	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	531								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						AATGCGGCCGAGAAGACCACC	0.557000													15	20					0	0	0.033300	0	0
NRXN1	9378	broad.mit.edu	37	2	51255230	51255230	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:51255230C>A	ENST00000404971.1	-	2	1521	c.182G>T	c.(181-183)cGc>cTc	p.R61L	NRXN1_ENST00000405581.1_Missense_Mutation_p.R61L|NRXN1_ENST00000402717.3_Missense_Mutation_p.R61L|NRXN1_ENST00000405472.3_Missense_Mutation_p.R61L|NRXN1_ENST00000406316.2_Missense_Mutation_p.R61L|NRXN1_ENST00000401669.2_Missense_Mutation_p.R61L|NRXN1_ENST00000406859.3_Missense_Mutation_p.R61L	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	61	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GCGGGCGCTGCGAGTCTTGAG	0.672000													3	7					0.004672	0.00496736	0.115264	1	0
DOCK10	55619	broad.mit.edu	37	2	225681357	225681357	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:225681357G>T	ENST00000409592.3	-	30	3436	c.3323C>A	c.(3322-3324)cCc>cAc	p.P1108H	DOCK10_ENST00000258390.7_Missense_Mutation_p.P1114H			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1114							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGATCTTATGGGCAGACACAA	0.348000													15	53					2.32078e-09	2.84335e-09	0.132662	1	0
ACSL6	23305	broad.mit.edu	37	5	131310521	131310521	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:131310521C>T	ENST00000379244.1	-	11	1159	c.923G>A	c.(922-924)tGg>tAg	p.W308*	ACSL6_ENST00000544770.1_Intron|ACSL6_ENST00000543479.1_Nonsense_Mutation_p.W308*|ACSL6_ENST00000379272.2_Intron|ACSL6_ENST00000379240.1_Intron|ACSL6_ENST00000296869.4_Nonsense_Mutation_p.W333*|ACSL6_ENST00000431707.1_Intron|ACSL6_ENST00000379249.3_Nonsense_Mutation_p.W308*|ACSL6_ENST00000357096.1_Intron|ACSL6_ENST00000379246.1_Intron|ACSL6_ENST00000379255.1_Intron|ACSL6_ENST00000379264.2_Intron			Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	308					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGTGGGAGCCCACTGACTCTG	0.532000													7	14					0	0	0.038147	0	0
OR11L1	391189	broad.mit.edu	37	1	248004459	248004459	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:248004459A>G	ENST00000355784.2	-	1	795	c.740T>C	c.(739-741)gTt>gCt	p.V247A		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GAGAGTGACAACAGCCAGGTG	0.498000													36	79					0	0	0.092188	0	0
ACP6	51205	broad.mit.edu	37	1	147120191	147120191	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:147120191G>A	ENST00000369238.5	-	9	1447	c.1000C>T	c.(1000-1002)Cat>Tat	p.H334Y	ACP6_ENST00000460583.1_5'UTR	NM_016361.3	NP_057445.4	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	334					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					GTCACATCATGAGCCGCATAG	0.498000													28	176					0	0	0.050027	0	0
OC90	729330	broad.mit.edu	37	8	133067293	133067293	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:133067293G>T	ENST00000262283.5	-	5	668	c.569C>A	c.(568-570)cCc>cAc	p.P190H	OC90_ENST00000603859.1_5'UTR|OC90_ENST00000443356.2_5'UTR|OC90_ENST00000254627.3_5'UTR			Q02509	OC90_HUMAN	otoconin 90	0	Phospholipase A2-like 1.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			ACAAAGGATGGGGCTTAGGCA	0.498000													4	20					0.00024832	0.000270231	0.009096	1	0
CECR1	51816	broad.mit.edu	37	22	17690382	17690382	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:17690382C>A	ENST00000399839.1	-	2	456	c.186G>T	c.(184-186)agG>agT	p.R62S	CECR1_ENST00000399837.2_Missense_Mutation_p.R62S|CECR1_ENST00000449907.2_Missense_Mutation_p.R20S|CECR1_ENST00000262607.3_Missense_Mutation_p.R62S			Q9NZK5	CECR1_HUMAN	cat eye syndrome chromosome region, candidate 1	62	Dimerization.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	extracellular space|Golgi apparatus	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				GCGTCATGAGCCTCTCATTGG	0.532000													16	25					3.45872e-05	3.87796e-05	0.146539	1	0
SACS	26278	broad.mit.edu	37	13	23910183	23910183	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr13:23910183G>T	ENST00000382298.3	-	10	8420	c.7832C>A	c.(7831-7833)aCg>aAg	p.T2611K	SACS_ENST00000382292.3_Missense_Mutation_p.T2611K|SACS_ENST00000402364.1_Missense_Mutation_p.T1861K	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2611					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TCCCTCTTTCGTGCCTTTTCC	0.413000													8	42					0.000274275	0.000295005	0.047766	1	0
C3AR1	719	broad.mit.edu	37	12	8211392	8211392	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:8211392G>A	ENST00000307637.4	-	2	1593	c.1390C>T	c.(1390-1392)Cgt>Tgt	p.R464C		NM_004054.2	NP_004045.1	Q16581	C3AR_HUMAN	complement component 3a receptor 1	464					blood circulation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response	integral to plasma membrane	C3a anaphylatoxin receptor activity|complement component C3a receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)	20				Kidney(36;0.0893)		TGGGTGGAACGTGTGAGCTCC	0.468000													28	177					0	0	0.108266	0	0
PLS1	5357	broad.mit.edu	37	3	142402908	142402908	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:142402908G>T	ENST00000337777.3	+	7	853	c.640G>T	c.(640-642)Ggt>Tgt	p.G214C	PLS1_ENST00000497002.1_Missense_Mutation_p.G214C|PLS1_ENST00000457734.2_Missense_Mutation_p.G214C	NM_002670.2	NP_002661.2	Q14651	PLSI_HUMAN	plastin 1	214	Actin-binding 1.|CH 1.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	27						GGTCAACATTGGTGCATCAGA	0.408000													40	93					4.16155e-14	5.38382e-14	0.104719	1	0
ACP6	51205	broad.mit.edu	37	1	147120177	147120177	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:147120177G>A	ENST00000369238.5	-	9	1461	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F	ACP6_ENST00000460583.1_5'UTR	NM_016361.3	NP_057445.4	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	338					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					AGAGCGGTATGAAGGTCACAT	0.493000													31	171					0	0	0.059317	0	0
ILKAP	80895	broad.mit.edu	37	2	239082240	239082240	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:239082240C>A	ENST00000254654.3	-	10	1066	c.891G>T	c.(889-891)caG>caT	p.Q297H		NM_030768.2	NP_110395.1	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated serine/threonine phosphatase	297	PP2C-like.					cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		AGCGCTTGTACTGCCCGTCCC	0.542000													5	12					3.59834e-05	3.98618e-05	0.021553	1	0
OR8H3	390152	broad.mit.edu	37	11	55890174	55890174	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:55890174C>A	ENST00000313472.3	+	1	326	c.326C>A	c.(325-327)aCt>aAt	p.T109N		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TTCTTGGGTACTGCTGAATGT	0.458000													79	104					7.14593e-30	1.0492e-29	0.139131	1	0
LINC01410	103352539	broad.mit.edu	37	9	66459850	66459850	+	RNA	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:66459850T>A	ENST00000424345.1	+	0	110																											ggtgaggtcatgttttcctgg	0.363000													3	29					0	0	0.009096	0	0
PHLDB2	90102	broad.mit.edu	37	3	111637972	111637972	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:111637972A>T	ENST00000431670.2	+	4	2184	c.1773A>T	c.(1771-1773)gaA>gaT	p.E591D	PHLDB2_ENST00000481953.1_Missense_Mutation_p.E591D|PHLDB2_ENST00000495180.1_Missense_Mutation_p.E177D|PHLDB2_ENST00000393925.3_Missense_Mutation_p.E591D|PHLDB2_ENST00000393923.3_Missense_Mutation_p.E618D|PHLDB2_ENST00000412622.1_Missense_Mutation_p.E591D	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	591						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						CTGCAATGGAAGAAACCCGGA	0.403000													104	187					0	0	0.139131	0	0
GGH	8836	broad.mit.edu	37	8	63948311	63948311	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:63948311C>T	ENST00000260118.6	-	2	530	c.128G>A	c.(127-129)tGc>tAc	p.C43Y		NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	43	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	TTTATTACGGCATTTTTGCAT	0.328000													25	59					0	0	0.083992	0	0
TEAD3	7005	broad.mit.edu	37	6	35444189	35444189	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:35444189G>A	ENST00000338863.7	-	9	843	c.616C>T	c.(616-618)Ccc>Tcc	p.P206S	TEAD3_ENST00000402886.3_Missense_Mutation_p.P146S	NM_003214.3	NP_003205.2	Q99594	TEAD3_HUMAN	TEA domain family member 3	206	Pro-rich.|Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	10						GCAGCTGAGGGGAGCGGGGCC	0.602000													43	23					0	0	0.139131	0	0
CD1E	913	broad.mit.edu	37	1	158324234	158324234	+	Silent	SNP	T	T	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:158324234T>G	ENST00000368160.3	+	2	126	c.126T>G	c.(124-126)acT>acG	p.T42T	CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368156.1_Silent_p.T42T|CD1E_ENST00000368163.3_Silent_p.T42T|CD1E_ENST00000434258.1_Silent_p.T40T|CD1E_ENST00000368167.3_Silent_p.T42T|CD1E_ENST00000368155.3_Silent_p.T42T|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000464822.1_Intron|CD1E_ENST00000368165.3_Silent_p.T42T|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368164.3_Intron|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368161.3_Silent_p.T42T	NM_001042583.2	NP_001036048.1	P15812	CD1E_HUMAN	CD1e molecule	42					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					TGCTCCAAACTTCCTCCTTTG	0.557000													14	221					0	0	0.119110	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85459115	85459115	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:85459115C>T	ENST00000393217.2	+	9	2528	c.2467C>T	c.(2467-2469)Cta>Tta	p.L823L		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	823										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TCTTCAGTTTCTATCCCTTCG	0.413000													35	93					0	0	0.069456	0	0
IL16	3603	broad.mit.edu	37	15	81585074	81585074	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:81585074C>A	ENST00000394660.2	+	12	1958	c.1598C>A	c.(1597-1599)cCg>cAg	p.P533Q	IL16_ENST00000302987.4_Missense_Mutation_p.P533Q	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	533					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GCTGAGAAGCCGTCCTCTGAC	0.617000													20	52					2.4624e-09	2.97741e-09	0.049695	1	0
KCNS2	3788	broad.mit.edu	37	8	99440881	99440881	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:99440881C>T	ENST00000287042.4	+	2	1024	c.674C>T	c.(673-675)cCt>cTt	p.P225L	KCNS2_ENST00000521839.1_Missense_Mutation_p.P225L	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	225						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGCGAGGACCCTAGGTTCGAA	0.547000													19	61					0	0	0.076483	0	0
DAB2	1601	broad.mit.edu	37	5	39382954	39382954	+	Silent	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:39382954C>A	ENST00000545653.1	-	9	1574	c.1044G>T	c.(1042-1044)tcG>tcT	p.S348S	DAB2_ENST00000509337.1_Silent_p.S348S|DAB2_ENST00000339788.6_Intron|DAB2_ENST00000320816.6_Silent_p.S369S	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	369					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GCTGGGTTTGCGAACTTGAAA	0.502000													34	68					2.08457e-15	2.75461e-15	0.045705	1	0
AGTPBP1	23287	broad.mit.edu	37	9	88247825	88247825	+	Silent	SNP	T	T	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:88247825T>C	ENST00000357081.3	-	14	1911	c.1767A>G	c.(1765-1767)ctA>ctG	p.L589L	AGTPBP1_ENST00000432218.1_Silent_p.L427L|AGTPBP1_ENST00000376109.3_Silent_p.L601L|AGTPBP1_ENST00000376083.3_Silent_p.L549L|AGTPBP1_ENST00000337006.4_3'UTR			Q9UPW5	CBPC1_HUMAN	ATP/GTP binding protein 1	589					C-terminal protein deglutamylation|cerebellar Purkinje cell differentiation|eye photoreceptor cell differentiation|mitochondrion organization|neuromuscular process|olfactory bulb development|protein side chain deglutamylation|proteolysis	cytosol|mitochondrion|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(12)|ovary(5)|skin(2)|urinary_tract(3)	44						AAAGCTTCCCTAGCTGAACTG	0.448000													14	24					0	0	0.105934	0	0
EFCAB5	374786	broad.mit.edu	37	17	28405290	28405290	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:28405290C>T	ENST00000394835.3	+	15	2987	c.2795C>T	c.(2794-2796)tCa>tTa	p.S932L	EFCAB5_ENST00000320856.5_Missense_Mutation_p.S808L|EFCAB5_ENST00000394832.2_Intron	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	932							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						AGATTGTCTTCAAAACAATTT	0.383000													4	185					0	0	0.009096	0	0
ECEL1	9427	broad.mit.edu	37	2	233346507	233346507	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:233346507C>A	ENST00000304546.1	-	13	2059	c.1849G>T	c.(1849-1851)Ggc>Tgc	p.G617C	ECEL1_ENST00000409941.1_Missense_Mutation_p.G615C	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	617					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCGTCGTAGCCGTGGGTCAGC	0.662000													12	19					2.31682e-05	2.61349e-05	0.132662	1	0
PCDH15	65217	broad.mit.edu	37	10	55582503	55582503	+	Silent	SNP	T	T	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr10:55582503T>G	ENST00000361849.3	-	34	5383	c.4989A>C	c.(4987-4989)tcA>tcC	p.S1663S	PCDH15_ENST00000437009.1_Silent_p.S1592S|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395430.1_Silent_p.S1658S|PCDH15_ENST00000395432.2_Silent_p.S1621S|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000320301.6_Silent_p.S1661S|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395433.1_Silent_p.S1638S|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395445.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1661					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GAAAGCAAAATGAAGAGTCTG	0.418000										HNSCC(58;0.16)			22	95					0	0	0.055883	0	0
NBPF12	149013	broad.mit.edu	37	1	146398472	146398472	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:146398472G>T	ENST00000442909.2	+	7	1294	c.458G>T	c.(457-459)aGa>aTa	p.R153I	NBPF12_ENST00000309471.8_Missense_Mutation_p.R78I|NBPF12_ENST00000446760.2_Missense_Mutation_p.R153I					neuroblastoma breakpoint family, member 12											ovary(2)	2						GAGGGGTGTAGACTGGCACAG	0.582000													34	95					1.60099e-16	2.14625e-16	0.074837	1	0
PCDH15	65217	broad.mit.edu	37	10	56423945	56423945	+	Silent	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr10:56423945G>T	ENST00000373965.2	-	2	472	c.78C>A	c.(76-78)ggC>ggA	p.G26G	PCDH15_ENST00000437009.1_Silent_p.G26G|PCDH15_ENST00000395430.1_Silent_p.G26G|PCDH15_ENST00000395432.2_Silent_p.G26G|PCDH15_ENST00000373957.3_Silent_p.G26G|PCDH15_ENST00000320301.6_Silent_p.G26G|PCDH15_ENST00000395446.1_Silent_p.G26G|PCDH15_ENST00000395438.1_Silent_p.G26G|PCDH15_ENST00000409834.1_5'UTR|PCDH15_ENST00000373955.1_Silent_p.G26G|PCDH15_ENST00000395433.1_Silent_p.G26G|PCDH15_ENST00000395442.1_Silent_p.G26G|PCDH15_ENST00000414778.1_Silent_p.G26G|PCDH15_ENST00000395440.1_Silent_p.G26G|PCDH15_ENST00000361849.3_Silent_p.G26G|PCDH15_ENST00000395445.1_Silent_p.G26G	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	26					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CATCATACTGGCCCAAGCAGA	0.388000										HNSCC(58;0.16)			22	41					2.27731e-05	2.58467e-05	0.062417	1	0
KIAA1107	23285	broad.mit.edu	37	1	92649455	92649455	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:92649455C>T	ENST00000409154.4	+	9	3798	c.3798C>T	c.(3796-3798)acC>acT	p.T1266T	KIAA1107_ENST00000370378.4_Silent_p.T1211T			Q9UPP5	K1107_HUMAN	KIAA1107	1266										breast(4)|central_nervous_system(1)|endometrium(3)|kidney(2)|prostate(1)|skin(3)	14						TGGCACAAACCCGCATGTATG	0.383000													10	16					0	0	0.069234	0	0
TOR1A	1861	broad.mit.edu	37	9	132585000	132585000	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:132585000C>A	ENST00000351698.4	-	2	352	c.304G>T	c.(304-306)Ggg>Tgg	p.G102W	TOR1A_ENST00000473084.1_5'UTR	NM_000113.2	NP_000104.1	O14656	TOR1A_HUMAN	torsin family 1, member A (torsin A)	102					chaperone mediated protein folding requiring cofactor|response to unfolded protein	endoplasmic reticulum lumen|nuclear membrane	ATP binding|serine-type endopeptidase activity|unfolded protein binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20		Ovarian(14;0.00556)				CCTGTCCACCCGTGCAGGGAG	0.478000													24	36					3.01185e-09	3.61813e-09	0.091800	1	0
MT-ND5	4540	broad.mit.edu	37	MT	13112	13112	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrM:13112T>C	ENST00000361567.2	+	1	776	c.776T>C	c.(775-777)tTa>tCa	p.L259S				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	259					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	AGGAATCTTCTTACTCATCCG	0.527000													29	1108					0	0	0.069288	0	0
GATM	2628	broad.mit.edu	37	15	45660326	45660326	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:45660326C>A	ENST00000396659.3	-	4	956	c.617G>T	c.(616-618)cGt>cTt	p.R206L	GATM_ENST00000558336.1_Missense_Mutation_p.R206L	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	206					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	CTTGGCGCCACGGTGGAAGTA	0.463000													12	25					1.61879e-10	2.02349e-10	0.093190	1	0
SLC4A4	8671	broad.mit.edu	37	4	72205152	72205152	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:72205152C>T	ENST00000340595.3	+	1	383	c.187C>T	c.(187-189)Cag>Tag	p.Q63*	SLC4A4_ENST00000425175.1_Nonsense_Mutation_p.Q107*|SLC4A4_ENST00000512686.1_Nonsense_Mutation_p.Q63*|SLC4A4_ENST00000351898.6_Nonsense_Mutation_p.Q107*|SLC4A4_ENST00000264485.5_Nonsense_Mutation_p.Q107*|SLC4A4_ENST00000514331.1_3'UTR	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	107						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			AGCTCCCCCTCAGCTCTTCAC	0.537000													45	117					0	0	0.124865	0	0
PDE3A	5139	broad.mit.edu	37	12	20766498	20766498	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:20766498G>T	ENST00000359062.3	+	3	1173	c.1133G>T	c.(1132-1134)aGc>aTc	p.S378I	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	378					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AGAGCCGTGAGCAACTTGCTC	0.557000													48	67					1.19451e-25	1.74004e-25	0.139131	1	0
RANBP6	26953	broad.mit.edu	37	9	6013939	6013939	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:6013939C>A	ENST00000259569.5	-	1	1679	c.1669G>T	c.(1669-1671)Gaa>Taa	p.E557*	RANBP6_ENST00000485372.1_5'UTR	NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	557					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		AGCTTGAGTTCCTTCTGAACA	0.378000													18	26					3.41278e-10	4.23735e-10	0.033300	1	0
MADD	8567	broad.mit.edu	37	11	47306739	47306739	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:47306739G>C	ENST00000342922.4	+	13	2762	c.2405G>C	c.(2404-2406)gGc>gCc	p.G802A	MADD_ENST00000395336.3_Missense_Mutation_p.G802A|MADD_ENST00000402192.2_Missense_Mutation_p.G802A|MADD_ENST00000395344.3_Intron|MADD_ENST00000311027.5_Missense_Mutation_p.G802A|MADD_ENST00000407859.3_Intron|MADD_ENST00000406482.1_Intron|MADD_ENST00000402799.1_Intron|MADD_ENST00000349238.3_Missense_Mutation_p.G802A	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	802					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		CATGTCAGTGGCAATCGGTGA	0.532000													6	7					0	0	0.021553	0	0
DHX9	1660	broad.mit.edu	37	1	182822532	182822532	+	Silent	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:182822532G>A	ENST00000367549.3	+	5	566	c.456G>A	c.(454-456)aaG>aaA	p.K152K		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	152	Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						ACTCAAGAAAGGAAGAACAAG	0.458000													13	29					0	0	0.119110	0	0
ERLEC1	27248	broad.mit.edu	37	2	54028655	54028655	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:54028655A>C	ENST00000185150.4	+	7	778	c.647A>C	c.(646-648)cAt>cCt	p.H216P	ASB3_ENST00000498475.2_Intron|ERLEC1_ENST00000378239.5_Missense_Mutation_p.H216P|ASB3_ENST00000406625.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron|ERLEC1_ENST00000405123.3_Missense_Mutation_p.H216P	NM_015701.4	NP_056516.2	Q96DZ1	ERLEC_HUMAN	endoplasmic reticulum lectin 1	216					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|stomach(1)|urinary_tract(1)	18						TACATATGTCATCCTGAATCT	0.398000													29	72					0	0	0.125774	0	0
CHD3	1107	broad.mit.edu	37	17	7809893	7809893	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:7809893C>T	ENST00000380358.4	+	29	4559	c.4558C>T	c.(4558-4560)Cgc>Tgc	p.R1520C	CHD3_ENST00000330494.7_Missense_Mutation_p.R1461C|CHD3_ENST00000358181.4_Missense_Mutation_p.R1461C	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1461					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding	p.R1461C(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				TTTGTTCATGCGCCATCTGTG	0.607000													6	371					0	0	0.029380	0	0
ACP6	51205	broad.mit.edu	37	1	147120085	147120085	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:147120085G>A	ENST00000369238.5	-	9	1553	c.1106C>T	c.(1105-1107)tCt>tTt	p.S369F	ACP6_ENST00000460583.1_5'UTR	NM_016361.3	NP_057445.4	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic	369					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding	p.S369F(1)		breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(4)|prostate(1)	16	all_hematologic(923;0.0276)					CCACTCCTTAGATTCCAGGTG	0.527000													35	157					0	0	0.098360	0	0
KEAP1	9817	broad.mit.edu	37	19	10610279	10610279	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:10610279G>A	ENST00000171111.5	-	2	978	c.431C>T	c.(430-432)tCc>tTc	p.S144F	KEAP1_ENST00000393623.2_Missense_Mutation_p.S144F	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	144	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.S144F(2)		breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CATGGAGATGGAGGCCGTGTA	0.587000													6	15					0	0	0.021553	0	0
RGPD4	285190	broad.mit.edu	37	2	108488344	108488344	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:108488344G>T	ENST00000408999.3	+	20	3961	c.3884G>T	c.(3883-3885)aGt>aTt	p.S1295I	RGPD4_ENST00000354986.4_Missense_Mutation_p.S1295I	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1295					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TCTAACTTCAGTTTTAAATCT	0.408000													83	197					6.11987e-43	9.13046e-43	0.139131	1	0
PTPRH	5794	broad.mit.edu	37	19	55696925	55696925	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:55696925G>T	ENST00000376350.3	-	18	3029	c.3007C>A	c.(3007-3009)Ctt>Att	p.L1003I	PTPRH_ENST00000263434.5_Missense_Mutation_p.L825I	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1003	Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CACTGCCGAAGCATCCTCCAG	0.627000													4	6					0.0381472	0.0394259	0.038147	1	0
KLHDC4	54758	broad.mit.edu	37	16	87742907	87742907	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:87742907T>A	ENST00000270583.5	-	10	1469	c.1411A>T	c.(1411-1413)Atg>Ttg	p.M471L	KLHDC4_ENST00000353170.5_Missense_Mutation_p.M414L|KLHDC4_ENST00000347925.5_Missense_Mutation_p.M440L|KLHDC4_ENST00000566349.1_5'UTR	NM_017566.3	NP_060036.2	Q8TBB5	KLDC4_HUMAN	kelch domain containing 4	471										breast(2)|endometrium(3)|lung(10)|pancreas(2)|prostate(1)|skin(1)|urinary_tract(2)	21				BRCA - Breast invasive adenocarcinoma(80;0.0283)		CACGCCTCCATCCTGTGCAGG	0.667000													13	25					0	0	0.119110	0	0
CLDN11	5010	broad.mit.edu	37	3	170141044	170141044	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:170141044G>A	ENST00000064724.3	+	2	522	c.320G>A	c.(319-321)cGg>cAg	p.R107Q	CLDN11_ENST00000451576.1_Missense_Mutation_p.R107Q|CLDN11_ENST00000489485.1_3'UTR|CLDN11_ENST00000486975.1_Missense_Mutation_p.R107Q	NM_005602.5	NP_005593.2	O75508	CLD11_HUMAN	claudin 11	107					calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|liver(2)|lung(3)|ovary(2)	12	all_cancers(22;5.62e-23)|all_epithelial(15;7.54e-28)|all_lung(20;2.51e-17)|Lung NSC(18;1.02e-16)|Ovarian(172;0.000567)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CCCTGCATCCGGATGGGCCAG	0.607000													4	40					0	0	0.009096	0	0
ALOXE3	59344	broad.mit.edu	37	17	8018989	8018989	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:8018989C>A	ENST00000380149.1	-	3	868	c.838G>T	c.(838-840)Gac>Tac	p.D280Y	ALOXE3_ENST00000318227.3_Missense_Mutation_p.D256Y|ALOXE3_ENST00000448843.2_Missense_Mutation_p.D124Y			Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3	124	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)	31						GGAAGAGAGTCCTGACAAATA	0.502000													31	44					1.30897e-18	1.82075e-18	0.144211	1	0
MEGF8	1954	broad.mit.edu	37	19	42856543	42856543	+	Silent	SNP	C	C	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:42856543C>T	ENST00000334370.4	+	18	3719	c.3084C>T	c.(3082-3084)ccC>ccT	p.P1028P	MEGF8_ENST00000251268.6_Silent_p.P1095P	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1095						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TGAACACGCCCCTCAGCTACG	0.677000													2	3					0	0	0.115264	0	0
TUBA3C	7278	broad.mit.edu	37	13	19752442	19752442	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr13:19752442G>C	ENST00000400113.3	-	3	423	c.319C>G	c.(319-321)Cat>Gat	p.H107D		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	107					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		ATGGTGTAATGGCCTCTGGCG	0.537000													18	56					0	0	0.038395	0	0
GOLIM4	27333	broad.mit.edu	37	3	167750636	167750636	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:167750636G>A	ENST00000470487.1	-	9	1537	c.848C>T	c.(847-849)tCt>tTt	p.S283F	GOLIM4_ENST00000309027.4_Missense_Mutation_p.S255F	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	283					transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						ATTATTTCGAGACACCTAGGC	0.443000													27	71					0	0	0.108266	0	0
VAX2	25806	broad.mit.edu	37	2	71159913	71159913	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:71159913A>T	ENST00000234392.2	+	3	484	c.452A>T	c.(451-453)cAg>cTg	p.Q151L		NM_012476.2	NP_036608.1	Q9UIW0	VAX2_HUMAN	ventral anterior homeobox 2	151					ectoderm development|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)	7						GTCTGGTTCCAGAACCGCCGC	0.617000													5	12					0	0	0.014758	0	0
RNF168	165918	broad.mit.edu	37	3	196229919	196229919	+	Silent	SNP	C	C	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:196229919C>A	ENST00000318037.3	-	1	720	c.126G>T	c.(124-126)tcG>tcT	p.S42S		NM_152617.3	NP_689830.2	Q8IYW5	RN168_HUMAN	ring finger protein 168, E3 ubiquitin protein ligase	42					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)	20	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		TTTCGACGGTCGACTGGAAGC	0.582000													35	45					2.40579e-17	3.2487e-17	0.086207	1	0
ZNF543	125919	broad.mit.edu	37	19	57839964	57839964	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:57839964G>T	ENST00000321545.4	+	4	1479	c.1134G>T	c.(1132-1134)gaG>gaT	p.E378D		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	378					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTTTTTGCGAGAGTGCAGACC	0.512000													18	11					5.35267e-07	6.18902e-07	0.043863	1	0
ZNF100	163227	broad.mit.edu	37	19	21910652	21910652	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:21910652C>G	ENST00000358296.6	-	5	660	c.462G>C	c.(460-462)gaG>gaC	p.E154D	ZNF100_ENST00000305570.6_Missense_Mutation_p.E90D	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	154					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						GCACTTTACACTCATCCACAC	0.323000													3	70					0	0	0.115264	0	0
POM121L12	285877	broad.mit.edu	37	7	53104222	53104222	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:53104222G>T	ENST00000408890.4	+	1	874	c.858G>T	c.(856-858)gaG>gaT	p.E286D		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	286										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						TCGCCCTCGAGGTCACCCAGT	0.617000													31	33					1.36615e-20	1.91467e-20	0.054565	1	0
SCN10A	6336	broad.mit.edu	37	3	38793872	38793872	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:38793872T>A	ENST00000449082.2	-	11	1592	c.1593A>T	c.(1591-1593)gaA>gaT	p.E531D		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	531					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CCCGATGGCTTTCGTGGTCTC	0.607000													17	25					0	0	0.049695	0	0
ZCCHC3	85364	broad.mit.edu	37	20	279019	279019	+	Silent	SNP	G	G	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:279019G>T	ENST00000382352.3	+	1	1283	c.792G>T	c.(790-792)acG>acT	p.T264T		NM_033089.6	NP_149080.2	Q9NUD5	ZCHC3_HUMAN	zinc finger, CCHC domain containing 3	264							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(2)	8		all_cancers(10;0.000209)|Lung NSC(37;0.0417)|all_lung(30;0.0713)|all_epithelial(17;0.0748)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.149)			GGAACGAGACGGTGGACGTGG	0.607000													28	54					1.7881e-09	2.20533e-09	0.134883	1	0
CYP4F24P	388514	broad.mit.edu	37	19	15871148	15871148	+	RNA	SNP	C	C	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:15871148C>G	ENST00000587443.2	-	0	1464					NR_033864.1																						TCCGTGTGGTCCAGCAGGAAG	0.667000													12	10					0	0	0.105934	0	0
LOC284632	284632	broad.mit.edu	37	1	24529611	24529627	+	RNA	DEL	CCCTGCTGCCCACACAT	CCCTGCTGCCCACACAT	-	rs71029527		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:24529611_24529627delCCCTGCTGCCCACACAT	ENST00000439059.2	+	0	288					NR_027087.2																						TCCCACACACCCCTGCTGCCCACACATCCCTGCTGCC	0.604													4	2	---	---	---	---					
RP1-125I3.2	0	broad.mit.edu	37	1	26186959	26186960	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:26186959_26186960insT	ENST00000455431.1	+	0	263																											AAATTTTGTAATTTTTTTTTTT	0.554													4	6	---	---	---	---					
SDC3	9672	broad.mit.edu	37	1	31347369	31347370	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:31347369_31347370insC	ENST00000336798.7	-	2	2254_2255	c.762_763insG	c.(760-765)ggccagfs	p.Q255fs	SDC3_ENST00000339394.6_Frame_Shift_Ins_p.Q313fs			O75056	SDC3_HUMAN	syndecan 3	313	Ser/Thr-rich (mucin-like).					integral to membrane	cytoskeletal protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Myeloproliferative disorder(586;0.0393)|Colorectal(325;0.0466)|all_neural(195;0.0966)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)		STAD - Stomach adenocarcinoma(196;0.0197)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCACTGGGCCCCCCACTCA	0.609													11	268	---	---	---	---					
ZRANB2-AS2	100852410	broad.mit.edu	37	1	71627981	71627981	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:71627981delT	ENST00000455406.1	+	0	131				ZRANB2-AS2_ENST00000596952.1_RNA|ZRANB2-AS2_ENST00000415780.1_RNA	NR_046217.1																						ccttgcttcctcttcaccttc	0.448													4	4	---	---	---	---					
MGC27382	149047	broad.mit.edu	37	1	78729632	78729632	+	RNA	DEL	T	T	-	rs79073963		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:78729632delT	ENST00000436742.1	+	0	1342																											tcaaacataataaaaaaaaaa	0.388													3	6	---	---	---	---					
MGC27382	149047	broad.mit.edu	37	1	78733453	78733454	+	RNA	INS	-	-	CCCT	rs138438688	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:78733453_78733454insCCCT	ENST00000436742.1	+	0	1342																											AAAATCATCTCCcctccctccc	0.371													5	1	---	---	---	---					
LOC101928241	101928241	broad.mit.edu	37	1	96795228	96795228	+	RNA	DEL	T	T	-	rs71068877		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:96795228delT	ENST00000435311.1	-	0	165																											TTTGTGTGTGTTTTTTTTTAT	0.368													4	4	---	---	---	---					
LOC440600	440600	broad.mit.edu	37	1	110832284	110832284	+	RNA	DEL	T	T	-	rs35312587		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:110832284delT	ENST00000449169.1	-	0	414					NR_036595.1																						TAAGATGGGAttttttttttt	0.488													2	4	---	---	---	---					
LOC101929147	101929147	broad.mit.edu	37	1	119746440	119746441	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:119746440_119746441insC	ENST00000418015.1	+	0	430				RP11-418J17.1_ENST00000413531.1_RNA																							gaaaatactttccccccaatat	0.391													2	4	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142647307	142647313	+	RNA	DEL	GTGTGTG	GTGTGTG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:142647307_142647313delGTGTGTG	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							gtgtgtgtgtgtgtgtgtgtgtgtgtg	0.411													2	4	---	---	---	---					
RP11-423O2.5	0	broad.mit.edu	37	1	142809179	142809180	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:142809179_142809180insT	ENST00000423385.1	-	0	88																											gatgatgagcattttttcatgt	0.366													2	4	---	---	---	---					
LOC101928979	101928979	broad.mit.edu	37	1	145381736	145381736	+	RNA	DEL	A	A	-	rs150712838		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:145381736delA	ENST00000419817.1	-	0	307																											catcctggctaacagagtgaa	0.552													2	4	---	---	---	---					
LINC00862	554279	broad.mit.edu	37	1	200317686	200317686	+	RNA	DEL	G	G	-	rs113495575		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:200317686delG	ENST00000367355.1	-	0	550					NR_040064.1																						actctgtctcggaaaaaaaaa	0.537													2	4	---	---	---	---					
TMEM78	677790	broad.mit.edu	37	1	229385670	229385671	+	Frame_Shift_Del	DEL	TC	TC	-	rs71561726		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr1:229385670_229385671delTC	ENST00000323223.2	+	1	288_289	c.229_230delTC	c.(229-231)tfs	p.S77fs						transmembrane protein 78																		tctctctctttctctctttctt	0.465													6	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12599041	12599041	+	RNA	DEL	A	A	-	rs112071661		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:12599041delA	ENST00000412294.1	+	0	412																											taattccagcacattgggagg	0.493													4	2	---	---	---	---					
AC010745.4	0	broad.mit.edu	37	2	16499410	16499411	+	RNA	INS	-	-	G	rs140534138	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:16499410_16499411insG	ENST00000420130.1	-	0	171																											aggcaaagagagaagggagagt	0.535													3	4	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34062574	34062575	+	RNA	INS	-	-	A	rs2001633	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:34062574_34062575insA	ENST00000366209.2	+	0	68																											tccatccccccaaaaaaaaaga	0.441													2	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35258132	35258133	+	RNA	INS	-	-	GGAA	rs35076891	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:35258132_35258133insGGAA	ENST00000588944.1	+	0	115																											aaaggaagaagggaaggaagga	0.530													3	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35352618	35352619	+	RNA	INS	-	-	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:35352618_35352619insA	ENST00000588944.1	+	0	115																											aatggaaagccaaaaaaaagca	0.376													2	4	---	---	---	---					
AC079807.4	0	broad.mit.edu	37	2	48333164	48333165	+	RNA	INS	-	-	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:48333164_48333165insG	ENST00000447571.1	-	0	240																		p.0?(2)									GGAAGCAGTGCGGGGGAAGCTA	0.515													2	4	---	---	---	---					
AC010967.2	0	broad.mit.edu	37	2	53076449	53076450	+	RNA	INS	-	-	T	rs35109740	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:53076449_53076450insT	ENST00000421575.1	-	0	119																											ctgaagtttcctttttttgttg	0.406													3	6	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	59927783	59927783	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:59927783delT	ENST00000606382.1	-	0	236																											gttgtctgtgtttttttttcc	0.373													2	4	---	---	---	---					
LOC100507073	100507073	broad.mit.edu	37	2	66869564	66869565	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:66869564_66869565insC	ENST00000433396.1	+	0	136																											taagcaatcctcccccctcagc	0.475													2	4	---	---	---	---					
LOC101927701	101927701	broad.mit.edu	37	2	68031949	68031950	+	RNA	INS	-	-	A	rs34913115		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:68031949_68031950insA	ENST00000457448.1	-	0	180																											gaatccgtctcaaaaaaaaaaa	0.460													4	5	---	---	---	---					
WBP1	23559	broad.mit.edu	37	2	74687542	74687543	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:74687542_74687543insC	ENST00000393972.3	+	5	849_850	c.646_647insC	c.(646-648)cccfs	p.P216fs	WBP1_ENST00000494741.1_3'UTR|WBP1_ENST00000409737.1_Frame_Shift_Ins_p.P179fs|WBP1_ENST00000233615.2_Frame_Shift_Ins_p.P182fs			Q96G27	WBP1_HUMAN	WW domain binding protein 1	182							WW domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|ovary(1)|urinary_tract(1)	8						CCACCAGAGTGCCCCCCCTCAT	0.604													8	68	---	---	---	---					
LINC01291	102724515	broad.mit.edu	37	2	75159095	75159096	+	RNA	DEL	GA	GA	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:75159095_75159096delGA	ENST00000377469.1	+	0	3298																											gtagggaaaggagagagagaga	0.455													2	4	---	---	---	---					
AC012442.5	0	broad.mit.edu	37	2	113363217	113363218	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:113363217_113363218insT	ENST00000414784.1	+	0	206																											tactctctctctttttttttga	0.401													3	3	---	---	---	---					
AC012363.4	0	broad.mit.edu	37	2	120938854	120938855	+	RNA	INS	-	-	A	rs112313964		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:120938854_120938855insA	ENST00000455707.1	-	0	205																											gaccctgtttcaaaaaaaaaaa	0.500													2	4	---	---	---	---					
AC012501.2	0	broad.mit.edu	37	2	154287042	154287043	+	RNA	DEL	GA	GA	-	rs117767059		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:154287042_154287043delGA	ENST00000424322.1	-	0	429																											GGTAGGTagggagagagagaga	0.381													3	3	---	---	---	---					
LOC101929532	101929532	broad.mit.edu	37	2	163018464	163018465	+	RNA	INS	-	-	G	rs116268321	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:163018464_163018465insG	ENST00000418968.2	+	0	132																											ACTAAAAATGTGGGGGGGGGAG	0.436													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164958763	164958764	+	RNA	DEL	AG	AG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:164958763_164958764delAG	ENST00000429636.1	-	0	196																											acagagagaaagagagagagag	0.332													2	4	---	---	---	---					
CRYGB	1419	broad.mit.edu	37	2	209007411	209007412	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:209007411_209007412insC	ENST00000260988.4	-	3	525_526	c.478_479insG	c.(478-480)tccfs	p.S160fs		NM_005210.3	NP_005201.2	P07316	CRGB_HUMAN	crystallin, gamma B	160	Beta/gamma crystallin 'Greek key' 4.				visual perception		structural constituent of eye lens			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)	14				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		GGCATTTGGAGCCCCCCAATCA	0.465													8	171	---	---	---	---					
AC009410.1	0	broad.mit.edu	37	2	229410268	229410269	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:229410268_229410269insT	ENST00000432481.2	-	0	144																											TGTGTTTCTTGTTTTTTTGACT	0.356													2	4	---	---	---	---					
AC079135.1	0	broad.mit.edu	37	2	237200946	237200946	+	RNA	DEL	T	T	-	rs112406422		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr2:237200946delT	ENST00000415226.1	+	0	397																											TTGCAAAGTATTTTTTTTTTT	0.448													4	4	---	---	---	---					
AC026167.1	0	broad.mit.edu	37	3	6242701	6242702	+	RNA	DEL	AC	AC	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:6242701_6242702delAC	ENST00000435651.1	+	0	95																											acacacacagacacacacacac	0.361													3	4	---	---	---	---					
LMCD1-AS1	100288428	broad.mit.edu	37	3	8006219	8006220	+	RNA	DEL	AG	AG	-	rs13085046		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:8006219_8006220delAG	ENST00000441861.1	-	0	508				LMCD1-AS1_ENST00000446281.1_RNA																							acacacacacagagagagagag	0.485													6	4	---	---	---	---					
AC098973.2	0	broad.mit.edu	37	3	27870010	27870011	+	RNA	INS	-	-	T	rs112148897	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:27870010_27870011insT	ENST00000414382.1	+	0	336																											gctgaatccagttttttgtttt	0.351													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64806803	64806803	+	RNA	DEL	C	C	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:64806803delC	ENST00000474768.1	+	0	573				ADAMTS9-AS2_ENST00000481312.1_RNA																							TTTTGAGTCTCAAAATTGTTC	0.373													3	3	---	---	---	---					
LINC00877	285286	broad.mit.edu	37	3	72258857	72258858	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:72258857_72258858insC	ENST00000491567.1	-	0	78																											CAGGATCCCTTCCCCCCCACGA	0.426													3	5	---	---	---	---					
DZIP3	9666	broad.mit.edu	37	3	108403180	108403181	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:108403180_108403181insC	ENST00000361582.3	+	27	3231_3232	c.3001_3002insC	c.(3001-3003)cccfs	p.P1001fs	DZIP3_ENST00000463306.1_Frame_Shift_Ins_p.P1001fs	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	1001					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CCAACCTAGAGCCCCCCTGGTA	0.411													7	371	---	---	---	---					
NPHP3-AS1	348808	broad.mit.edu	37	3	132579748	132579749	+	RNA	DEL	TG	TG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:132579748_132579749delTG	ENST00000504440.1	+	0	1824					NR_002811.1																						ATAGTGAGCCtgtgtgtgtgtg	0.391													2	4	---	---	---	---					
TFP1	100129696	broad.mit.edu	37	3	133455550	133455550	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:133455550delA	ENST00000460564.1	+	0	381																											aacaaagattaaaaaaaagac	0.303													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153590088	153590088	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:153590088delA	ENST00000488210.1	-	0	477																											ctgatgaaagaaattgaagag	0.303													2	4	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172890620	172890629	+	RNA	DEL	CACATGTATA	CACATGTATA	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:172890620_172890629delCACATGTATA	ENST00000447709.1	+	0	22																											accaacatggcacatgtatacatatgtaac	0.310													2	4	---	---	---	---					
LINC01206	100996490	broad.mit.edu	37	3	181692689	181692690	+	RNA	INS	-	-	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:181692689_181692690insA	ENST00000482787.3	+	0	714																											gactccgtctcaaaaaaaaaaa	0.436													4	2	---	---	---	---					
LOC100507391	100507391	broad.mit.edu	37	3	194464636	194464636	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr3:194464636delT	ENST00000423318.1	+	0	727					NR_037891.1																						ctaagtggccttttttcccct	0.522													2	4	---	---	---	---					
TMED11P	100379220	broad.mit.edu	37	4	1124022	1124023	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:1124022_1124023insC	ENST00000504969.1	+	0	114																											AAATGTCCTAACCCCCCCACGT	0.465											OREG0016029	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
RGS12	6002	broad.mit.edu	37	4	3424168	3424168	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:3424168delC	ENST00000336727.3	+	11	3808	c.2904delC	c.(2902-2904)ctfs	p.L968fs	RGS12_ENST00000508158.1_3'UTR|RGS12_ENST00000538395.1_Frame_Shift_Del_p.L310fs|RGS12_ENST00000382788.3_Frame_Shift_Del_p.L968fs|RGS12_ENST00000306648.7_Frame_Shift_Del_p.L366fs|RGS12_ENST00000338806.4_Frame_Shift_Del_p.L320fs|RGS12_ENST00000344733.5_Frame_Shift_Del_p.L968fs	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	968	RBD 1.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCATTCATCTCCCGGATGGGA	0.627													2	4	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15260477	15260480	+	RNA	DEL	GTTG	GTTG	-	rs10578607		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:15260477_15260480delGTTG	ENST00000502344.1	-	0	154																											attttgccctgttggtcaggctgt	0.534													3	5	---	---	---	---					
RP11-141E13.1	0	broad.mit.edu	37	4	17061202	17061203	+	RNA	INS	-	-	G	rs149072303	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:17061202_17061203insG	ENST00000511735.1	-	0	154																											GCAGGCCACTTGCTTTAGCCCC	0.599													7	2	---	---	---	---					
RP11-292B1.2	0	broad.mit.edu	37	4	29008231	29008232	+	RNA	INS	-	-	A	rs36189350		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:29008231_29008232insA	ENST00000514802.1	+	0	348																											tatgcagccataaaaaggatga	0.396													3	3	---	---	---	---					
FIP1L1	81608	broad.mit.edu	37	4	54319248	54319249	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:54319248_54319249delAG	ENST00000337488.6	+	16	1641_1642	c.1447_1448delAG	c.(1447-1449)afs	p.R483fs	FIP1L1_ENST00000358575.5_Frame_Shift_Del_p.R477fs|FIP1L1_ENST00000306932.6_Frame_Shift_Del_p.R409fs|FIP1L1_ENST00000507166.1_Intron	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	483	Arg-rich.|Glu-rich.|Sufficient for interaction with CPSF1 and CSTF3.				mRNA processing	nucleus	RNA binding	p.R487fs*3(2)		large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			agaACGCACCAGAGAGAGAGAG	0.470			T	PDGFRA	idiopathic hypereosinophilic syndrome								9	121	---	---	---	---					
LOC101928851	101928851	broad.mit.edu	37	4	58305593	58305593	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:58305593delT	ENST00000510956.1	+	0	544																											gccattcacattttttttttt	0.358													3	4	---	---	---	---					
RP11-625I7.1	0	broad.mit.edu	37	4	78402783	78402783	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:78402783delA	ENST00000513871.1	-	0	122																											gttattgattaatactttaat	0.378													2	4	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82928397	82928397	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:82928397delA	ENST00000510780.1	-	0	244																											TGCCCACGTTAAAAGAATTGT	0.383													2	4	---	---	---	---					
RP11-767N15.1	0	broad.mit.edu	37	4	84608329	84608330	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:84608329_84608330insT	ENST00000510169.1	-	0	218																											CTCTTCTGAGAttttttttttt	0.480													3	6	---	---	---	---					
LOC101929468	101929468	broad.mit.edu	37	4	105463634	105463635	+	RNA	INS	-	-	AGA	rs142362671	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:105463634_105463635insAGA	ENST00000500179.1	+	0	96																											aaccagttgagagaacataaat	0.416													5	10	---	---	---	---					
SEC24B-AS1	100533182	broad.mit.edu	37	4	110297956	110297956	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:110297956delT	ENST00000499713.2	-	0	723				SEC24B-AS1_ENST00000505895.1_RNA																							TGTCCCTTCCTTGCACTGCCA	0.507													2	4	---	---	---	---					
LINC01378	103689918	broad.mit.edu	37	4	118599215	118599215	+	RNA	DEL	C	C	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:118599215delC	ENST00000422145.3	+	0	263																											actctcgatacccactgccct	0.458													2	4	---	---	---	---					
RP11-714L20.1	0	broad.mit.edu	37	4	138494688	138494688	+	RNA	DEL	T	T	-	rs66825196		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:138494688delT	ENST00000507365.1	+	0	80																											CCTCTAACCATTTTTCATGTG	0.383													3	4	---	---	---	---					
LINC00616	641365	broad.mit.edu	37	4	138978500	138978500	+	RNA	DEL	C	C	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:138978500delC	ENST00000514600.1	-	0	870					NR_037866.1																						agggcagtttcccccgttctg	0.458													2	4	---	---	---	---					
RP13-578N3.3	0	broad.mit.edu	37	4	144785274	144785275	+	RNA	INS	-	-	T	rs34779056	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:144785274_144785275insT	ENST00000499587.2	+	0	496																											TGAGAGCTGGCGCAAGCTTGAG	0.515													4	3	---	---	---	---					
RP11-6E9.4	0	broad.mit.edu	37	4	170905105	170905106	+	RNA	INS	-	-	AAAT	rs10527426	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr4:170905105_170905106insAAAT	ENST00000508955.1	+	0	142																											ATTGTGAAAACAATTTAGGCTG	0.277													3	3	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9864744	9864745	+	RNA	INS	-	-	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:9864744_9864745insA	ENST00000511616.1	-	0	521				RP11-447B18.1_ENST00000508097.1_lincRNA	NR_027112.2																						agactccactcaaaaaaaaaaa	0.450													3	3	---	---	---	---					
LOC285696	285696	broad.mit.edu	37	5	17143587	17143588	+	RNA	INS	-	-	CTAA	rs147374273	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:17143587_17143588insCTAA	ENST00000399760.2	-	0	1068					NR_027253.1																						TTCCTAACTTTCTATGTCTGCC	0.485													4	4	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21564316	21564317	+	RNA	DEL	TC	TC	-	rs71607535		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:21564316_21564317delTC	ENST00000607545.1	+	0	314					NR_027026.1																						AAGGAGCCTTTCTCTGCCTGAA	0.361													4	4	---	---	---	---					
CTD-2353F22.1	0	broad.mit.edu	37	5	36690894	36690894	+	RNA	DEL	C	C	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:36690894delC	ENST00000510740.1	-	0	60																											TGCCTCATCTCCCTTCTCTCC	0.507											OREG0016568	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
MEF2C-AS1	101929423	broad.mit.edu	37	5	88595381	88595388	+	RNA	DEL	ACACACAC	ACACACAC	-	rs55923004		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:88595381_88595388delACACACAC	ENST00000512585.1	+	0	319				MEF2C-AS1_ENST00000514092.1_RNA																							agtattctaaacacacacacacacacac	0.332													5	4	---	---	---	---					
MEF2C-AS1	101929423	broad.mit.edu	37	5	88605210	88605211	+	RNA	DEL	CA	CA	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:88605210_88605211delCA	ENST00000514092.1	+	0	244																											TGTGATTTACCACACACACACA	0.396													3	4	---	---	---	---					
RP11-133F8.2	0	broad.mit.edu	37	5	91951345	91951346	+	RNA	DEL	AG	AG	-	rs34141820		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:91951345_91951346delAG	ENST00000512210.1	-	0	52																											TATGGAAGAAAGCATTAGATGT	0.446													5	3	---	---	---	---					
RP11-155G15.2	0	broad.mit.edu	37	5	96578433	96578433	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:96578433delT	ENST00000504578.1	+	0	71																											ATGAAGACAGTTTTCTCCCAT	0.463													2	4	---	---	---	---					
RP11-6N13.1	0	broad.mit.edu	37	5	104590751	104590752	+	RNA	INS	-	-	GAAT			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:104590751_104590752insGAAT	ENST00000503650.1	-	0	210																											aaggagggaaggaaggaaggaa	0.485													2	4	---	---	---	---					
CTC-551A13.1	0	broad.mit.edu	37	5	110307915	110307915	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:110307915delT	ENST00000507627.1	-	0	482																											AGTCAAAACCTTTTTTAGCAA	0.353													2	4	---	---	---	---					
RP11-492A10.1	0	broad.mit.edu	37	5	113840504	113840507	+	RNA	DEL	AGAG	AGAG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:113840504_113840507delAGAG	ENST00000514115.1	-	0	331																											tgcgtgagatagagagagagagag	0.461													2	4	---	---	---	---					
RP11-492A10.1	0	broad.mit.edu	37	5	113915910	113915910	+	RNA	DEL	A	A	-	rs35454360		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:113915910delA	ENST00000514115.1	-	0	331																											CTACCTTTATAAAAAAATACA	0.333													7	0	---	---	---	---					
CTB-11I22.1	0	broad.mit.edu	37	5	158649451	158649451	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:158649451delA	ENST00000521204.1	+	0	191																											cctgtctcttaaaaaaaaaaa	0.453													2	4	---	---	---	---					
NEURL1B	54492	broad.mit.edu	37	5	172113708	172113709	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr5:172113708_172113709insC	ENST00000369800.5	+	5	1589_1590	c.1448_1449insC	c.(1447-1449)accfs	p.T483fs	NEURL1B_ENST00000522853.1_Frame_Shift_Ins_p.T301fs|NEURL1B_ENST00000520919.1_Frame_Shift_Ins_p.T243fs	NM_001142651.1	NP_001136123.1	A8MQ27	NEU1B_HUMAN	neuralized E3 ubiquitin protein ligase 1B	483	Ser-rich.						ligase activity|zinc ion binding			endometrium(2)	2						TCCCCGCTGAGCCCCCCGGTGT	0.619													2	4	---	---	---	---					
RP11-532F6.4	0	broad.mit.edu	37	6	733501	733501	+	RNA	DEL	T	T	-	rs137899133		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:733501delT	ENST00000607644.1	+	0	243																											AGGGAAGCTATTTTTTTTTTT	0.353													3	5	---	---	---	---					
LOC101928106	101928106	broad.mit.edu	37	6	10476389	10476390	+	RNA	DEL	TC	TC	-	rs143840920		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:10476389_10476390delTC	ENST00000431401.1	-	0	162																											gagaacagtttctgttgttttt	0.505													6	2	---	---	---	---					
HCP5	10866	broad.mit.edu	37	6	31430539	31430539	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:31430539delA	ENST00000414046.2	+	0	62					NR_040662.1		Q6MZN7	HCP5_HUMAN							defense response					urinary_tract(1)	1						AAGGAATGGGAGGCAGGAAGT	0.552													4	3	---	---	---	---					
RP1-179N16.6	0	broad.mit.edu	37	6	36155408	36155408	+	RNA	DEL	T	T	-	rs78855599		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:36155408delT	ENST00000499560.2	-	0	265				RP1-179N16.6_ENST00000526611.1_RNA																							cttttcttggtttttttttct	0.363													3	4	---	---	---	---					
TDRG1	732253	broad.mit.edu	37	6	40314634	40314636	+	RNA	DEL	CAT	CAT	-	rs59852583		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:40314634_40314636delCAT	ENST00000451810.1	+	0	313				TDRG1_ENST00000448559.1_RNA																							TAATGattaccatcatcatcatc	0.409													4	2	---	---	---	---					
TDRD6	221400	broad.mit.edu	37	6	46660414	46660415	+	Frame_Shift_Ins	INS	-	-	A	rs145334816		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr6:46660414_46660415insA	ENST00000544460.1	+	1	4803_4804	c.4549_4550insA	c.(4549-4551)aaafs	p.K1517fs	TDRD6_ENST00000316081.6_Frame_Shift_Ins_p.K1517fs	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1517					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GTATAATCCAGAAAAAAAAATG	0.351													7	157	---	---	---	---					
JAZF1-AS1	100128081	broad.mit.edu	37	7	28279443	28279443	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:28279443delA	ENST00000455963.1	+	0	301				JAZF1-AS1_ENST00000436758.1_RNA																							AAACATGCAGAAGATTTCCTC	0.468													2	4	---	---	---	---					
AC002127.4	0	broad.mit.edu	37	7	88349371	88349371	+	RNA	DEL	A	A	-	rs35087888		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:88349371delA	ENST00000444032.1	+	0	65																											catttttgataatatctgtct	0.308													4	2	---	---	---	---					
AZGP1P1	646282	broad.mit.edu	37	7	99581178	99581179	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:99581178_99581179insC	ENST00000425474.1	+	0	499_500					NR_036679.1																						TCCGCATCCCACCCCCCCCACA	0.579													3	6	---	---	---	---					
LOC101928012	101928012	broad.mit.edu	37	7	112266744	112266759	+	RNA	DEL	TGGCCTCCCAGAGTGC	TGGCCTCCCAGAGTGC	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:112266744_112266759delTGGCCTCCCAGAGTGC	ENST00000453459.1	+	0	242																											ccacccaccttggcctcccagagtgctgggattaca	0.495													3	6	---	---	---	---					
LOC101928012	101928012	broad.mit.edu	37	7	112331038	112331039	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:112331038_112331039insC	ENST00000453459.1	+	0	580																											ctgcacaccctccccccaaatc	0.381													2	4	---	---	---	---					
RP11-61D3.1	0	broad.mit.edu	37	7	122719065	122719067	+	RNA	DEL	TTG	TTG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:122719065_122719067delTTG	ENST00000420146.2	-	0	135																											GCTTTGAAGTTTGTTGTTGTTGT	0.379													2	4	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142482025	142482025	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr7:142482025delA	ENST00000603901.1	+	0	591					NR_001296.3																						TGCAGTGCCCACATGGAGAAG	0.572													7	23	---	---	---	---					
LINC01288	103689844	broad.mit.edu	37	8	34649578	34649579	+	RNA	INS	-	-	T	rs10540834		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:34649578_34649579insT	ENST00000519189.1	+	0	45																											AAGAAAAGGTGTTTTTTTTTTT	0.302													2	4	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36402268	36402268	+	RNA	DEL	A	A	-	rs77180107		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:36402268delA	ENST00000524132.1	-	0	484																											actcaaaaggaaaaaaaaaaa	0.403													2	4	---	---	---	---					
LOC102723701	102723701	broad.mit.edu	37	8	37593487	37593487	+	Frame_Shift_Del	DEL	A	A	-	rs112819064		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:37593487delA	ENST00000330539.1	-	2	877	c.529delT	c.(529-531)ctfs	p.S177fs																								TCAAGGAGAGAAAAAAAAAAA	0.458													2	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	64878660	64878660	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:64878660delT	ENST00000524360.1	-	0	195				RP11-32K4.1_ENST00000523191.1_RNA|RP11-32K4.1_ENST00000521958.1_RNA																							ccttccttcctccctccctcc	0.363													4	7	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96488130	96488131	+	RNA	INS	-	-	T	rs35974799		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:96488130_96488131insT	ENST00000521905.1	+	0	281																											GTCCTGGTAAGTTTTTTTTTTT	0.401													2	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117032559	117032560	+	RNA	INS	-	-	A	rs34518892	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:117032559_117032560insA	ENST00000505156.2	-	0	1558					NR_046215.1																						GAAACAAAGACAAAAAAAAAAA	0.391													3	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117152350	117152351	+	RNA	INS	-	-	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:117152350_117152351insG	ENST00000505156.2	-	0	1333					NR_046215.1																						ttctgatcccagggggggctct	0.505													3	3	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130685914	130685915	+	RNA	INS	-	-	T	rs77533437		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:130685914_130685915insT	ENST00000446592.3	-	0	312																											ATCGTTAAGTCTTTTTTTTTGC	0.480													4	2	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142445062	142445063	+	RNA	INS	-	-	G	rs79308669	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr8:142445062_142445063insG	ENST00000606664.1	+	0	418_419				MROH5_ENST00000430863.1_RNA																							TGGGACGGGCTGGGGGCCCTGG	0.644													6	4	---	---	---	---					
ATP8B5P	158381	broad.mit.edu	37	9	35447285	35447285	+	RNA	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:35447285delG	ENST00000430846.1	+	0	2365																											CAGGAATACTGACCTATAAGG	0.428													2	4	---	---	---	---					
LOC340512	340512	broad.mit.edu	37	9	109781277	109781277	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:109781277delT	ENST00000439901.1	-	0	455																											GCAGCTAGCCTTTTTAAATTC	0.408													2	4	---	---	---	---					
RP11-202G18.1	0	broad.mit.edu	37	9	113919494	113919495	+	RNA	INS	-	-	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr9:113919494_113919495insG	ENST00000426204.1	-	0	370																											ctggtatatgcgggggggattg	0.431													2	4	---	---	---	---					
SEPHS1	22929	broad.mit.edu	37	10	13371759	13371762	+	Frame_Shift_Del	DEL	AGCA	AGCA	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr10:13371759_13371762delAGCA	ENST00000327347.5	-	6	962_965	c.587_590delTGCT	c.(586-591)ggfs	p.VL198fs	SEPHS1_ENST00000378614.4_Frame_Shift_Del_p.VL198fs|SEPHS1_ENST00000537130.1_Frame_Shift_Del_p.VL131fs|SEPHS1_ENST00000545675.1_Frame_Shift_Del_p.VL198fs	NM_001195602.1|NM_012247.4	NP_001182531.1|NP_036379.2	P49903	SPS1_HUMAN	selenophosphate synthetase 1	198					protein modification process		ATP binding|GTP binding|selenide, water dikinase activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|stomach(1)	16						TGTCAGCACCAGCACGTCCCCTGG	0.515													4	8	---	---	---	---					
OR5G5P	81191	broad.mit.edu	37	11	56583930	56583930	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:56583930delA	ENST00000378368.2	-	0	128																											ttgtccacctaagcatttctc	0.323													2	4	---	---	---	---					
LOC283214	283214	broad.mit.edu	37	11	75473759	75473759	+	RNA	DEL	A	A	-	rs5792702		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:75473759delA	ENST00000499390.2	-	0	905					NR_046090.1																						actccgtctcaaaaaaaaaaa	0.423													3	5	---	---	---	---					
LOC646522	646522	broad.mit.edu	37	11	133678454	133678455	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr11:133678454_133678455insC	ENST00000526254.1	-	0	121																											TGTGGCTTCTACCCCCGCTGAA	0.520													2	4	---	---	---	---					
CACNA1C-IT1	100874368	broad.mit.edu	37	12	2128655	2128656	+	RNA	INS	-	-	AGGG	rs139670456	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:2128655_2128656insAGGG	ENST00000542984.1	+	0	80																											aaagaaaagaaagggagggagg	0.450													2	4	---	---	---	---					
ATN1	1822	broad.mit.edu	37	12	7045699	7045700	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:7045699_7045700insC	ENST00000356654.4	+	5	1506_1507	c.1269_1270insC	c.(1267-1272)caccccfs	p.HP423fs	ATN1_ENST00000396684.2_Frame_Shift_Ins_p.HP423fs	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	423					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						TCTCCAATCAGCCCCCCAAGTA	0.614													7	255	---	---	---	---					
LOC728715	728715	broad.mit.edu	37	12	9714223	9714224	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:9714223_9714224insT	ENST00000520314.1	+	0	1418_1419																											CTTTCCCCTCCTTTTTTTCCCT	0.450													2	4	---	---	---	---					
RP11-871F6.3	0	broad.mit.edu	37	12	17699520	17699520	+	RNA	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:17699520delG	ENST00000540399.1	-	0	888																											acatttttatggaggttccct	0.308													2	4	---	---	---	---					
RP11-313F23.4	0	broad.mit.edu	37	12	34345095	34345095	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:34345095delT	ENST00000545923.2	-	0	347																											GTGGCTAAAATTTTAAAAACT	0.403													2	4	---	---	---	---					
RP11-478B9.1	0	broad.mit.edu	37	12	45488190	45488190	+	RNA	DEL	T	T	-	rs75346630		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:45488190delT	ENST00000548424.1	+	0	448																											TGTTTCATTCTTTTTTTTTTC	0.428													2	4	---	---	---	---					
RP11-446N19.1	0	broad.mit.edu	37	12	47035322	47035323	+	RNA	INS	-	-	A			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:47035322_47035323insA	ENST00000607353.1	+	0	287																											gcctaccaaccaaaaaaagccc	0.411													2	4	---	---	---	---					
RP11-150C16.1	0	broad.mit.edu	37	12	59429857	59429857	+	RNA	DEL	A	A	-	rs34751459		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:59429857delA	ENST00000547590.1	+	0	226																											AGTGTAAATGAAAAAAAAAAA	0.353													3	3	---	---	---	---					
IFNG-AS1	100885789	broad.mit.edu	37	12	68476421	68476422	+	RNA	INS	-	-	A	rs138246258	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:68476421_68476422insA	ENST00000536914.1	+	0	336																											taatacagagtaaaaaaaacaa	0.287													5	4	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	73775168	73775169	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:73775168_73775169insT	ENST00000549058.1	-	0	132																											tcctgttgatgtttttgcttca	0.347													2	4	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	74282988	74282990	+	RNA	DEL	CTT	CTT	-	rs151303576		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:74282988_74282990delCTT	ENST00000549058.1	-	0	60																											CCCACCCTAACTTCTTCAAGTTT	0.404													5	3	---	---	---	---					
RP11-13A1.3	0	broad.mit.edu	37	12	89447871	89447871	+	RNA	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:89447871delG	ENST00000549278.1	-	0	282																											agaacagcgtgggaaagactc	0.473													2	4	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97487328	97487328	+	RNA	DEL	A	A	-	rs76309124		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:97487328delA	ENST00000552238.1	+	0	39																											ttaggggaagaggctttctgt	0.453													5	3	---	---	---	---					
RMST	196475	broad.mit.edu	37	12	97958166	97958166	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:97958166delT	ENST00000538559.2	+	0	2320																											CCAAGAGTTGTTTTCCATGTA	0.458													2	4	---	---	---	---					
RP11-690J15.1	0	broad.mit.edu	37	12	98583925	98583925	+	RNA	DEL	A	A	-	rs72047439		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:98583925delA	ENST00000548344.1	-	0	68																											TCTTCTGTTTAAAAAAAAAAA	0.363													2	4	---	---	---	---					
RP11-328J6.1	0	broad.mit.edu	37	12	103526102	103526126	+	RNA	DEL	CTGGGGTCCTGAAATGGCTCCCTAA	CTGGGGTCCTGAAATGGCTCCCTAA	-	rs111481333		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:103526102_103526126delCTGGGGTCCTGAAATGGCTCCCTAA	ENST00000548594.1	-	0	167				RP11-328J6.1_ENST00000548415.1_RNA																							cagggcttggctggggtcctgaaatggctccctaacatgggaaaa	0.489													3	5	---	---	---	---					
RP11-1028N23.4	0	broad.mit.edu	37	12	116061445	116061445	+	RNA	DEL	C	C	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr12:116061445delC	ENST00000551940.1	-	0	90																											GTGCTTCCGGCCCTGGTGTAG	0.438													2	4	---	---	---	---					
RP11-478K15.1	0	broad.mit.edu	37	13	44706478	44706479	+	RNA	INS	-	-	CAAAAAATCACATTTCC	rs71099879	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr13:44706478_44706479insCAAAAAATCACATTTCC	ENST00000432331.1	-	0	134																											TCCTTAAGAAACAAAAAATCAC	0.426													2	4	---	---	---	---					
LINC00359	100887754	broad.mit.edu	37	13	97599672	97599673	+	RNA	INS	-	-	T			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr13:97599672_97599673insT	ENST00000442322.1	-	0	270																											ttttttggttgttttttttttt	0.535													3	5	---	---	---	---					
RP11-146E13.4	0	broad.mit.edu	37	14	19856349	19856350	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:19856349_19856350insC	ENST00000548109.1	+	0	72																											AAAAAACAAAAAACAACAAAAA	0.406													3	4	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	27903884	27903887	+	RNA	DEL	GTGC	GTGC	-	rs72286176		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:27903884_27903887delGTGC	ENST00000553392.1	-	0	262																											gtgtgtgtgtgtgCGCGCGCACAT	0.333													3	5	---	---	---	---					
RP11-148E17.1	0	broad.mit.edu	37	14	29478223	29478223	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:29478223delT	ENST00000551227.1	+	0	418																											CCTAAAGCCATTTTTTTTTCA	0.303													2	4	---	---	---	---					
CTD-2307P3.1	0	broad.mit.edu	37	14	43038535	43038536	+	RNA	DEL	GC	GC	-	rs116964338	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:43038535_43038536delGC	ENST00000557251.1	+	0	166																											AGGCAtgtgtgcgtgtgtgtgt	0.416													2	4	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44519362	44519363	+	RNA	INS	-	-	A	rs147693497	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:44519362_44519363insA	ENST00000553827.1	-	0	69																											TCTAGAGAAAGAAAAAAAAACT	0.322													5	2	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57363771	57363771	+	RNA	DEL	T	T	-	rs35539919		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:57363771delT	ENST00000534909.2	+	0	287				OTX2-AS1_ENST00000554428.1_RNA|OTX2-AS1_ENST00000554358.1_RNA|OTX2-AS1_ENST00000554725.1_RNA	NR_029385.1																						CTGTTAACACTTTTTTTTTTT	0.453													3	5	---	---	---	---					
CTD-2509G16.5	0	broad.mit.edu	37	14	65770235	65770235	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:65770235delA	ENST00000553754.1	-	0	300																											cgaagctaggaagcgacacag	0.512													2	4	---	---	---	---					
RP11-736P16.1	0	broad.mit.edu	37	14	87451926	87451926	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:87451926delT	ENST00000554181.1	+	0	188																											CTTCTCTCTCTTTTTTTTGCA	0.358													2	4	---	---	---	---					
GALC	2581	broad.mit.edu	37	14	88321371	88321371	+	RNA	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr14:88321371delG	ENST00000554305.1	-	0	17																											aaggttgtaaggagccagaaa	0.418													3	6	---	---	---	---					
LOC100128714	100128714	broad.mit.edu	37	15	26202157	26202158	+	RNA	DEL	CA	CA	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:26202157_26202158delCA	ENST00000383019.2	+	0	207					NR_040082.1																						CACcacataccacacacaacac	0.505													2	4	---	---	---	---					
RP11-184D12.1	0	broad.mit.edu	37	15	36379646	36379647	+	RNA	DEL	AG	AG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:36379646_36379647delAG	ENST00000561394.1	-	0	136																											aaggatagaaagagaattgtgg	0.361													2	4	---	---	---	---					
RP11-624L4.1	0	broad.mit.edu	37	15	39221547	39221548	+	RNA	INS	-	-	TCTT	rs148511181	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:39221547_39221548insTCTT	ENST00000560197.1	-	0	251				RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA																							tggatcttctctattagtcagc	0.322													2	4	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61769548	61769549	+	RNA	DEL	TG	TG	-	rs146605125		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:61769548_61769549delTG	ENST00000559783.1	-	0	186																											TTCAACAATATGTGTTTGCAAA	0.441													7	4	---	---	---	---					
LOC101928850	101928850	broad.mit.edu	37	15	61891177	61891178	+	RNA	DEL	CG	CG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:61891177_61891178delCG	ENST00000561182.1	+	0	88				RP11-507B12.2_ENST00000559783.1_lincRNA																							GTGCAACTCTCGCTTTTTTCTT	0.515													4	7	---	---	---	---					
LOC102723344	102723344	broad.mit.edu	37	15	63684434	63684435	+	RNA	INS	-	-	T	rs149085810		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:63684434_63684435insT	ENST00000559821.1	+	0	32																											GCTCTCttctcttttttttttt	0.490													4	2	---	---	---	---					
RP11-798K3.2	0	broad.mit.edu	37	15	67349064	67349064	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:67349064delT	ENST00000558071.1	-	0	114																											cttctctctcttttttttttt	0.458													2	4	---	---	---	---					
LOC102723640	102723640	broad.mit.edu	37	15	72901336	72901336	+	RNA	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:72901336delG	ENST00000565305.1	-	0	172																											CTTTGAAGGTGGGAATCTGGG	0.483													26	62	---	---	---	---					
EFTUD1P1	648809	broad.mit.edu	37	15	84763292	84763292	+	RNA	DEL	T	T	-	rs79110907		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:84763292delT	ENST00000558187.1	+	0	412																											cctgtgggaattttttttttt	0.353													2	4	---	---	---	---					
RP11-183E24.2	0	broad.mit.edu	37	15	98669465	98669466	+	RNA	DEL	TC	TC	-	rs10559601		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr15:98669465_98669466delTC	ENST00000559643.1	-	0	174				CTD-2544M6.1_ENST00000560360.1_lincRNA																							tcttcttcaatctctctctctc	0.505													3	6	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5321635	5321637	+	RNA	DEL	GAT	GAT	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:5321635_5321637delGAT	ENST00000569895.1	+	0	304																											ttagaaggtcgatgatgtgtccc	0.453													2	4	---	---	---	---					
CTD-3032H12.2	0	broad.mit.edu	37	16	54970046	54970047	+	RNA	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:54970046_54970047insC	ENST00000560487.1	+	0	179																											CTCCCCTCTCTCCCCCCACAGC	0.495													2	4	---	---	---	---					
HYDIN	54768	broad.mit.edu	37	16	70934982	70934983	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr16:70934982_70934983insG	ENST00000393567.2	-	53	9122_9123	c.8972_8973insC	c.(8971-8973)cgafs	p.R2991fs		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2991										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				ACTCAGCCTCAGGGGGGATGGT	0.574													7	728	---	---	---	---					
CTC-281F24.1	0	broad.mit.edu	37	17	6558134	6558135	+	RNA	DEL	CA	CA	-	rs66831436	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:6558134_6558135delCA	ENST00000576138.1	-	0	119																											GAAGGAGGCCCAGGGGAAGCGG	0.589													5	3	---	---	---	---					
RP11-260A9.6	0	broad.mit.edu	37	17	25318216	25318216	+	RNA	DEL	T	T	-	rs111803514		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:25318216delT	ENST00000580686.1	-	0	189																											TGCTGGCCTCTGGCAGGCTGG	0.612													3	3	---	---	---	---					
SDF2	6388	broad.mit.edu	37	17	26988862	26988863	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:26988862_26988863insC	ENST00000247020.4	-	1	330_331	c.32_33insG	c.(31-33)gttfs	p.V11fs	SDF2_ENST00000592250.1_Intron	NM_006923.3	NP_008854.2	Q99470	SDF2_HUMAN	stromal cell-derived factor 2	11					protein glycosylation	extracellular space|membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity	p.G11fs*20(1)		endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Lung NSC(42;0.00431)					CGCTCCACAAACCCCCCAACAA	0.584													8	166	---	---	---	---					
RP11-445F12.1	0	broad.mit.edu	37	17	35274569	35274570	+	RNA	DEL	CA	CA	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:35274569_35274570delCA	ENST00000532387.2	-	0	95				RP11-445F12.1_ENST00000529264.1_RNA|RP11-445F12.1_ENST00000528383.1_RNA																							cacatgcacgcacacacacaca	0.554													2	4	---	---	---	---					
NFE2L1	4779	broad.mit.edu	37	17	46133791	46133792	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:46133791_46133792insG	ENST00000362042.3	+	3	1170_1171	c.554_555insG	c.(553-555)cggfs	p.R185fs	NFE2L1_ENST00000583378.1_Frame_Shift_Ins_p.R16fs|NFE2L1_ENST00000582155.1_Frame_Shift_Ins_p.R27fs|NFE2L1_ENST00000536222.1_Frame_Shift_Ins_p.R59fs|NFE2L1_ENST00000585291.1_Frame_Shift_Ins_p.R185fs|NFE2L1_ENST00000361665.3_Frame_Shift_Ins_p.R174fs|NFE2L1_ENST00000357480.5_Frame_Shift_Ins_p.R185fs	NM_003204.2	NP_003195.1	Q14494	NF2L1_HUMAN	nuclear factor, erythroid 2-like 1	185	Asp/Glu-rich (acidic).				anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			cervix(1)|endometrium(3)|kidney(9)|large_intestine(7)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GATATTGATCTGGGGGCTGGGC	0.530													8	734	---	---	---	---					
RP11-515E23.1	0	broad.mit.edu	37	17	53547343	53547343	+	RNA	DEL	A	A	-	rs55821488		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:53547343delA	ENST00000577089.1	-	0	230																											aactccatctaaaaaaaaaac	0.498													4	8	---	---	---	---					
RP11-60A24.3	0	broad.mit.edu	37	17	55869092	55869093	+	RNA	INS	-	-	ATTG	rs145859019	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:55869092_55869093insATTG	ENST00000580960.1	-	0	254																											gaaaagcagacattgatcagat	0.436													3	3	---	---	---	---					
LINC01483	101928122	broad.mit.edu	37	17	67614850	67614851	+	RNA	INS	-	-	TC	rs150168385	by1000genomes	TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr17:67614850_67614851insTC	ENST00000433856.1	+	0	156																											TTTCGTCttcttttttttttga	0.386													5	1	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22326225	22326226	+	RNA	DEL	AC	AC	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:22326225_22326226delAC	ENST00000582650.1	+	0	235																											Gcacacacagacacacacacac	0.485													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37176580	37176580	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:37176580delT	ENST00000591629.1	-	0	282					NR_024391.1																						aagttctttcttatcttgccc	0.338													2	4	---	---	---	---					
TCEB3CL	728929	broad.mit.edu	37	18	44549025	44549026	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:44549025_44549026insGC	ENST00000451265.1	-	1	1508_1509	c.1273_1274insGC	c.(1273-1275)gcgfs	p.A425fs	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_001100817.1	NP_001094287.1			transcription elongation factor B polypeptide 3C-like											central_nervous_system(1)|lung(1)|prostate(1)	3						TCGCAGCCGCTGCTCTCGGGCG	0.554													4	3	---	---	---	---					
LOC643542	643542	broad.mit.edu	37	18	65474584	65474585	+	RNA	DEL	TG	TG	-	rs74385942		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr18:65474584_65474585delTG	ENST00000583687.1	+	0	204					NR_033921.1																						TGAGAGGCTTTGTAATAATTTA	0.371													3	4	---	---	---	---					
PIAS4	51588	broad.mit.edu	37	19	4028742	4028742	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:4028742delG	ENST00000262971.2	+	6	812	c.697delG	c.(697-699)ggfs	p.G233fs	PIAS4_ENST00000596144.1_3'UTR	NM_015897.2	NP_056981.2	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	233	PINIT.				positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(3)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CAATAAGCCCGGGGTGGAGCC	0.662													2	4	---	---	---	---					
RP11-255H23.4	0	broad.mit.edu	37	19	24038946	24038950	+	RNA	DEL	GAGAG	GAGAG	-	rs113882697		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:24038946_24038950delGAGAG	ENST00000599944.1	-	0	150																											aagaggtagagagagggttgccaga	0.493													3	4	---	---	---	---					
PCAT19	100505495	broad.mit.edu	37	19	41963184	41963184	+	RNA	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:41963184delG	ENST00000588495.1	-	0	1153					NR_040109.1																						aaaaaaaaaagaaaaCCAAAG	0.418													3	5	---	---	---	---					
PCAT19	100505495	broad.mit.edu	37	19	41974321	41974321	+	RNA	DEL	A	A	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:41974321delA	ENST00000588495.1	-	0	1153					NR_040109.1																						acaatatcacaaaaaaggtgt	0.388													2	4	---	---	---	---					
CEACAM22P	388550	broad.mit.edu	37	19	45041927	45041927	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:45041927delT	ENST00000446628.1	-	0	2133					NR_027754.1																						ATAACACttcttttttttttt	0.448													2	4	---	---	---	---					
BBC3	27113	broad.mit.edu	37	19	47725018	47725019	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr19:47725018_47725019insC	ENST00000449228.1	-	4	888_889	c.725_726insG	c.(724-726)gagfs	p.E242fs	BBC3_ENST00000341983.4_3'UTR|BBC3_ENST00000300880.7_Frame_Shift_Ins_p.E82fs|BBC3_ENST00000439096.2_3'UTR	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		GGAGGGGCCTGCCCCCCGAGTC	0.693													3	5	---	---	---	---					
SNAP25-AS1	100131208	broad.mit.edu	37	20	10130250	10130253	+	RNA	DEL	ACAC	ACAC	-	rs35169984		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:10130250_10130253delACAC	ENST00000603542.1	-	0	638				SNAP25-AS1_ENST00000605592.1_RNA|SNAP25-AS1_ENST00000426491.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25-AS1_ENST00000451151.1_RNA	NR_040710.1																						ATTCACCAAAacacacacacacac	0.397													3	5	---	---	---	---					
LOC100505664	100505664	broad.mit.edu	37	20	23169661	23169663	+	RNA	DEL	TGT	TGT	-	rs11470442		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr20:23169661_23169663delTGT	ENST00000411595.1	+	0	31																											gtgtatgtgatgttggtgtgtgt	0.433													4	5	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11072720	11072721	+	RNA	DEL	AC	AC	-	rs145587512		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr21:11072720_11072721delAC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aaaaaaaaaaacagtggccagg	0.431													3	6	---	---	---	---					
CYP4F29P	54055	broad.mit.edu	37	21	15218287	15218288	+	RNA	INS	-	-	T	rs147525289		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr21:15218287_15218288insT	ENST00000428301.1	-	0	595					NR_026755.1|NR_047508.1																						cctcagagtcacccacccaaag	0.535													2	4	---	---	---	---					
AP000476.1	0	broad.mit.edu	37	21	25818048	25818048	+	RNA	DEL	A	A	-	rs145414948		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr21:25818048delA	ENST00000453784.2	+	0	650																											TCAAAAACAGAAAAAAAAAAA	0.299													2	4	---	---	---	---					
AF131217.1	0	broad.mit.edu	37	21	29847318	29847319	+	RNA	INS	-	-	G	rs146335554		TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr21:29847318_29847319insG	ENST00000433310.1	-	0	456																											GTGGTTGAGGAGGGGGGGGTGG	0.460													5	3	---	---	---	---					
GRIK1	2897	broad.mit.edu	37	21	30953835	30953835	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr21:30953835delG	ENST00000399914.1	-	12	2298	c.1777delC	c.(1777-1779)acfs	p.H593fs	GRIK1_ENST00000399913.1_Frame_Shift_Del_p.H608fs|GRIK1_ENST00000309434.7_Frame_Shift_Del_p.H610fs|GRIK1_ENST00000389124.2_Frame_Shift_Del_p.H608fs|GRIK1_ENST00000535441.1_Frame_Shift_Del_p.H610fs|GRIK1_ENST00000327783.4_Frame_Shift_Del_p.H608fs|GRIK1_ENST00000399909.1_Frame_Shift_Del_p.H593fs|GRIK1_ENST00000389125.3_Frame_Shift_Del_p.H593fs|GRIK1_ENST00000399907.1_Frame_Shift_Del_p.H608fs			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	608					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	TTGCATGGGTGGGGGTTATAC	0.448													11	62	---	---	---	---					
LA16c-23H5.4	0	broad.mit.edu	37	22	16419352	16419352	+	RNA	DEL	T	T	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chr22:16419352delT	ENST00000444162.1	+	0	279																											GAATCGACGATTTTTTTTTTG	0.398													3	6	---	---	---	---					
NCBP2L	392517	broad.mit.edu	37	X	107027089	107027090	+	RNA	DEL	TG	TG	-			TCGA-17-Z011-01A-01W-0746-08	TCGA-17-Z011-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d7495a00-b312-4502-9e1b-9e5f3dbf4b5d	1c954e59-5ef6-4a1a-a28a-8f9f05adb632	g.chrX:107027089_107027090delTG	ENST00000509000.1	+	0	126																											ggtgtgcgtatgtgtgtgtgtg	0.421													2	4	---	---	---	---