Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHD8	57680	broad.mit.edu	37	14	21864052	21864052	+	Splice_Site	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:21864052C>T	ENST00000399982.2	-	27	5116		c.e27-1		CHD8_ENST00000555962.1_Splice_Site|CHD8_ENST00000430710.3_Splice_Site|CHD8_ENST00000557364.1_Splice_Site	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8						ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		AAAGTCAACCCTAAAATTATG	0.383000													20	161					0	0	0.069288	0	0
ST18	9705	broad.mit.edu	37	8	53055541	53055541	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:53055541G>C	ENST00000276480.7	-	17	2800	c.2117C>G	c.(2116-2118)cCa>cGa	p.P706R		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	706						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTTAGGGCTTGGTATAGAGGC	0.408000													18	127					0	0	0.049695	0	0
SIAH2	6478	broad.mit.edu	37	3	150459978	150459978	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:150459978C>T	ENST00000312960.3	-	2	1452	c.925G>A	c.(925-927)Gat>Aat	p.D309N		NM_005067.5	NP_005058.3	O43255	SIAH2_HUMAN	siah E3 ubiquitin protein ligase 2	309	SBD.				apoptosis|axon guidance|cell cycle|negative regulation of canonical Wnt receptor signaling pathway|small GTPase mediated signal transduction|ubiquitin-dependent protein catabolic process	cytosol|nucleus	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)	16			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			TTCCCATTATCTGCAAAAAGA	0.453000													13	73					0	0	0.132662	0	0
PHEX	5251	broad.mit.edu	37	X	22117197	22117197	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:22117197C>T	ENST00000379374.4	+	9	1572	c.1007C>T	c.(1006-1008)tCc>tTc	p.S336F	PHEX_ENST00000537599.1_Missense_Mutation_p.S336F|PHEX_ENST00000418858.3_Missense_Mutation_p.S39F|PHEX_ENST00000535894.1_Missense_Mutation_p.S239F|PHEX_ENST00000475778.1_3'UTR	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	336					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						ATCAGCCCCTCCGAGAATGTG	0.453000													27	124					0	0	0.050027	0	0
OR52E8	390079	broad.mit.edu	37	11	5878153	5878153	+	Silent	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:5878153T>A	ENST00000537935.1	-	1	811	c.780A>T	c.(778-780)gcA>gcT	p.A260A	TRIM5_ENST00000380027.1_Intron	NM_001005168.1	NP_001005168.1	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E, member 8	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGAAAAAAATGCTGGTGTAA	0.428000													12	87					0	0	0.105934	0	0
RYR3	6263	broad.mit.edu	37	15	33955863	33955863	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:33955863C>A	ENST00000389232.4	+	36	5614	c.5544C>A	c.(5542-5544)ctC>ctA	p.L1848L	RYR3_ENST00000415757.3_Silent_p.L1848L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1848	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ACAATGAGCTCATGCAGGCCC	0.577000													6	22					0.00116845	0.00136478	0.021553	1	0
TENM4	26011	broad.mit.edu	37	11	78433851	78433851	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:78433851T>G	ENST00000278550.7	-	24	4124	c.3662A>C	c.(3661-3663)aAc>aCc	p.N1221T		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		AGCAAGGCCGTTGCAGCTGGG	0.577000													6	46					0	0	0.029380	0	0
ASPM	259266	broad.mit.edu	37	1	197065250	197065250	+	Silent	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:197065250C>T	ENST00000367409.4	-	19	9121	c.8865G>A	c.(8863-8865)gtG>gtA	p.V2955V	ASPM_ENST00000367408.1_Silent_p.V620V|ASPM_ENST00000294732.7_Silent_p.V1370V	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	2955	IQ 34.|IQ 35.				mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						AGGCAGCTTTCACTTTACATA	0.318000													4	152					0	0	0.014758	0	0
TTLL5	23093	broad.mit.edu	37	14	76330023	76330023	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:76330023G>T	ENST00000298832.9	+	29	3545	c.3340G>T	c.(3340-3342)Ggg>Tgg	p.G1114W	TTLL5_ENST00000557636.1_Missense_Mutation_p.G1129W|TTLL5_ENST00000556893.1_Missense_Mutation_p.G665W|TTLL5_ENST00000554510.1_Missense_Mutation_p.G623W	NM_015072.4	NP_055887.3	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	1114					protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			NS(2)|breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(3)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(2)	50				BRCA - Breast invasive adenocarcinoma(234;0.029)		CCTGCAGACAGGGGGATTTGC	0.493000													15	108					1.5739e-10	2.31217e-10	0.146539	1	0
CACNA1E	777	broad.mit.edu	37	1	181752829	181752829	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:181752829G>A	ENST00000526775.1	+	39	5487	c.5322G>A	c.(5320-5322)atG>atA	p.M1774I	CACNA1E_ENST00000357570.5_Missense_Mutation_p.M1744I|CACNA1E_ENST00000367567.4_Missense_Mutation_p.M1400I|CACNA1E_ENST00000360108.3_Missense_Mutation_p.M1774I|CACNA1E_ENST00000367573.2_Missense_Mutation_p.M1793I|CACNA1E_ENST00000367570.1_Missense_Mutation_p.M1793I|CACNA1E_ENST00000358338.5_Missense_Mutation_p.M1725I	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1793	EF-hand.				energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TGGTCCTGATGAACATGCCAG	0.428000													6	147					0	0	0.029380	0	0
FHOD1	29109	broad.mit.edu	37	16	67266053	67266053	+	Silent	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:67266053G>C	ENST00000258201.4	-	14	2338	c.2091C>G	c.(2089-2091)ccC>ccG	p.P697P	FHOD1_ENST00000567687.1_Silent_p.P276P	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	697	FH2.|Interaction with ROCK1.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TGCTGCGCTTGGGGTCCAGCA	0.582000													4	36					0	0	0.014758	0	0
MSI1	4440	broad.mit.edu	37	12	120800882	120800882	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:120800882C>A	ENST00000257552.2	-	6	454	c.366G>T	c.(364-366)gtG>gtT	p.V122V		NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	122	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCACGTCCTCCACCGTGGTGT	0.542000													11	78					6.40141e-05	8.14465e-05	0.080935	1	0
COL4A5	1287	broad.mit.edu	37	X	107911647	107911647	+	Missense_Mutation	SNP	G	G	T	rs104886391		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:107911647G>T	ENST00000328300.6	+	41	3947	c.3703G>T	c.(3703-3705)Ggt>Tgt	p.G1235C	COL4A5_ENST00000361603.2_Missense_Mutation_p.G1235C	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1235	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TGGTGTGCAGGGTCCCCCAGG	0.607000									Alport syndrome with Diffuse Leiomyomatosis				3	31					1.024e-07	1.43764e-07	0.014758	1	0
SCN4A	6329	broad.mit.edu	37	17	62049174	62049174	+	Silent	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:62049174G>C	ENST00000435607.1	-	4	595	c.519C>G	c.(517-519)ctC>ctG	p.L173L	SCN4A_ENST00000578147.1_Silent_p.L173L	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	173					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GTATCTTGATGAGGGACTCAA	0.597000													3	26					0	0	0.115264	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	8902	8902	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrM:8902G>A	ENST00000361899.2	+	1	376	c.376G>A	c.(376-378)Gcc>Acc	p.A126T						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						AAAATGCCCTAGCCCACTTCT	0.473000													19	451					0	0	0.062417	0	0
PCLO	27445	broad.mit.edu	37	7	82582321	82582321	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:82582321C>A	ENST00000423517.2	-	5	8285	c.7948G>T	c.(7948-7950)Gct>Tct	p.A2650S	PCLO_ENST00000333891.8_Missense_Mutation_p.A2650S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2581					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACAGGGGTAGCAGAAAATGTC	0.443000													13	65					1.61879e-10	2.36593e-10	0.093190	1	0
RBFOX2	23543	broad.mit.edu	37	22	36141976	36141976	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:36141976G>A	ENST00000405409.2	-	11	1411	c.1043C>T	c.(1042-1044)gCg>gTg	p.A348V	RBFOX2_ENST00000416721.2_Silent_p.G360G|RBFOX2_ENST00000262829.7_Silent_p.G342G|RBFOX2_ENST00000414461.2_Missense_Mutation_p.A351V|RBFOX2_ENST00000397303.2_Silent_p.G341G|RBFOX2_ENST00000449924.2_Silent_p.G364G|RBFOX2_ENST00000359369.4_Missense_Mutation_p.A351V|RBFOX2_ENST00000438146.2_Silent_p.G435G	NM_001031695.2|NM_001082576.1|NM_001082577.1|NM_014309.2	NP_001026865.1|NP_001076045.1|NP_001076046.1|NP_055124.1	O43251	RFOX2_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 2	0	Ala-rich.				estrogen receptor signaling pathway|mRNA processing|negative regulation of transcription, DNA-dependent|regulation of cell proliferation|RNA splicing	cytoplasm|nucleus	nucleotide binding|RNA binding|transcription corepressor activity|transcription factor binding			endometrium(4)|large_intestine(7)|lung(7)	18						TTACCACAGCGCCAACTCCAT	0.443000													5	307					0	0	0.014758	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76501344	76501344	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:76501344G>T	ENST00000307431.8	+	11	1961	c.1576G>T	c.(1576-1578)Gat>Tat	p.D526Y	CNTNAP4_ENST00000476707.1_Missense_Mutation_p.D530Y|CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.D478Y|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.D454Y	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	527	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CAAAGTGGTAGATCTGATTTC	0.448000													8	37					1.06961e-07	1.48702e-07	0.038147	1	0
GLRA4	441509	broad.mit.edu	37	X	102962325	102962325	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:102962325G>A	ENST00000372617.4	-	9	1621	c.1201C>T	c.(1201-1203)Cca>Tca	p.P401S		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	401						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						AGAGGGGCTGGAGGTTGGGGA	0.522000													5	80					0	0	0.014758	0	0
ACO1	48	broad.mit.edu	37	9	32434696	32434696	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:32434696G>A	ENST00000379923.1	+	18	2302	c.2096G>A	c.(2095-2097)aGa>aAa	p.R699K	ACO1_ENST00000541043.1_Missense_Mutation_p.R600K|ACO1_ENST00000309951.5_Missense_Mutation_p.R699K	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	699					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding			breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		TTAACTAACAGAGGGTAAGTA	0.448000													5	89					0	0	0.029380	0	0
C2orf62	375307	broad.mit.edu	37	2	219231792	219231792	+	Silent	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:219231792C>T	ENST00000289388.3	+	8	830	c.801C>T	c.(799-801)atC>atT	p.I267I	C2orf62_ENST00000481940.1_3'UTR|AC021016.6_ENST00000441749.1_RNA	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	267										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGTGCTGCATCATCACCAAGA	0.582000													6	21					0	0	0.029380	0	0
ZNF708	7562	broad.mit.edu	37	19	21476864	21476864	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:21476864G>C	ENST00000356929.3	-	4	1101	c.904C>G	c.(904-906)Cat>Gat	p.H302D		NM_021269.2	NP_067092.2	P17019	ZN708_HUMAN	zinc finger protein 708	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H302Y(1)		breast(1)|central_nervous_system(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(2)|stomach(1)	32						TCTCCAGTATGAATTTTCTTG	0.378000													10	82					0	0	0.069234	0	0
ANPEP	290	broad.mit.edu	37	15	90348600	90348600	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:90348600G>A	ENST00000300060.6	-	3	1022	c.709C>T	c.(709-711)Ctt>Ttt	p.L237F		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	237	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GGGTGGATAAGCGTGATGTTG	0.637000													11	66					0	0	0.080935	0	0
IGF2R	3482	broad.mit.edu	37	6	160506118	160506118	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:160506118G>T	ENST00000356956.1	+	41	6308	c.6160G>T	c.(6160-6162)Gtc>Ttc	p.V2054F		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	2054					receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		AACTGGTGACGTCCAGGTCCT	0.522000													12	40					0.0931896	0.0972858	0.093190	1	0
LOC349160	349160	broad.mit.edu	37	7	136848963	136848963	+	RNA	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:136848963C>G	ENST00000439694.1	-	0	164				AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000599888.1_RNA																							TGAGTCGCACCAACCGACCAC	0.512000													6	43					0	0	0.021553	0	0
NLRC5	84166	broad.mit.edu	37	16	57059671	57059671	+	Silent	SNP	A	A	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:57059671A>G	ENST00000436936.1	+	6	1041	c.816A>G	c.(814-816)acA>acG	p.T272T	NLRC5_ENST00000539144.1_Silent_p.T272T|NLRC5_ENST00000262510.6_Silent_p.T272T|NLRC5_ENST00000308149.7_Silent_p.T272T			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	272	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GGTTCCTGACACCGTCCGAGC	0.542000													5	118					0	0	0.029380	0	0
GXYLT1	283464	broad.mit.edu	37	12	42499724	42499724	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:42499724C>T	ENST00000398675.3	-	5	992	c.760G>A	c.(760-762)Gga>Aga	p.G254R	GXYLT1_ENST00000280876.6_Missense_Mutation_p.G223R	NM_001099650.1|NM_173601.1	NP_001093120.1|NP_775872.1	Q4G148	GXLT1_HUMAN	glucoside xylosyltransferase 1	254					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity	p.G254I(1)|p.G223I(1)		kidney(2)|large_intestine(4)|liver(3)|lung(8)	17						TTATACCATCCTATTCGAGGT	0.368000													7	21					0	0	0.029380	0	0
MYH13	8735	broad.mit.edu	37	17	10222425	10222425	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:10222425G>T	ENST00000418404.3	-	26	3583	c.3420C>A	c.(3418-3420)cgC>cgA	p.R1140R	MYH13_ENST00000252172.4_Silent_p.R1140R|MYH13_ENST00000570743.1_Silent_p.R1140R			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1140					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCAGATCTGAGCGCTGCTTCT	0.532000													16	108					1.99824e-07	2.75119e-07	0.033300	1	0
BIRC6	57448	broad.mit.edu	37	2	32673994	32673994	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:32673994C>T	ENST00000421745.2	+	22	4750	c.4616C>T	c.(4615-4617)tCa>tTa	p.S1539L		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	1539					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					GATGTCCTTTCAGGTAGTGAT	0.323000													8	45					0	0	0.047766	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977358	29977358	+	RNA	SNP	T	T	C	rs146982767	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:29977358T>C	ENST00000376797.3	-	0	731				HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000420251.1_RNA																							GATTTGTTCATGCCTTCCCTT	0.448000													3	36					0	0	0.009096	0	0
ZNF142	7701	broad.mit.edu	37	2	219503289	219503289	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:219503289G>A	ENST00000411696.2	-	9	5616	c.4837C>T	c.(4837-4839)Ctc>Ttc	p.L1613F	ZNF142_ENST00000449707.1_Missense_Mutation_p.L1613F			P52746	ZN142_HUMAN	zinc finger protein 142	1613					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		GTGTGGGTGAGGGCATGATGG	0.612000													3	27					0	0	0.115264	0	0
TENM1	10178	broad.mit.edu	37	X	123519887	123519887	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:123519887G>T	ENST00000422452.2	-	29	5779	c.5716C>A	c.(5716-5718)Cgg>Agg	p.R1906R	TENM1_ENST00000371130.3_Silent_p.R1899R|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		ATGTAACGCCGCTGGCTGTGT	0.453000													11	66					9.05144e-12	1.34357e-11	0.105934	1	0
RYR2	6262	broad.mit.edu	37	1	237608767	237608767	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:237608767T>G	ENST00000366574.2	+	14	1554	c.1237T>G	c.(1237-1239)Tca>Gca	p.S413A	RYR2_ENST00000360064.6_Missense_Mutation_p.S411A|RYR2_ENST00000542537.1_Missense_Mutation_p.S397A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	413					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCATGAAGAATCACGCACAGC	0.403000													12	92					0	0	0.105934	0	0
EPN2	22905	broad.mit.edu	37	17	19186825	19186825	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:19186825G>T	ENST00000314728.5	+	3	877	c.393G>T	c.(391-393)gtG>gtT	p.V131V	EPN2_ENST00000571254.1_Silent_p.V131V|EPN2_ENST00000395626.1_Silent_p.V131V|EPN2_ENST00000575595.1_Intron|EPN2_ENST00000395620.2_Silent_p.V131V|EPN2_ENST00000395618.3_Intron|EPN2_ENST00000347697.2_Silent_p.V131V	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	131	ENTH.				endocytosis		lipid binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					AGCAACTGGTGGCTCTCCTCA	0.562000													18	86					0.000295444	0.000356786	0.069288	1	0
MAGI2	9863	broad.mit.edu	37	7	77649105	77649105	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:77649105C>T	ENST00000354212.4	-	22	4148	c.3895G>A	c.(3895-3897)Gag>Aag	p.E1299K	MAGI2_ENST00000419488.1_Missense_Mutation_p.E1285K|MAGI2_ENST00000522391.1_3'UTR	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1299						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GCTGAAAGCTCCTTTGGTTTC	0.652000													4	17					0	0	0.014758	0	0
TG	7038	broad.mit.edu	37	8	133898735	133898735	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:133898735C>A	ENST00000220616.4	+	9	1158	c.1118C>A	c.(1117-1119)tCc>tAc	p.S373Y	TG_ENST00000377869.1_Missense_Mutation_p.S373Y	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	373					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CAGGCCTTGTCCAGACTCTAC	0.502000													35	230					2.51541e-25	3.91744e-25	0.074837	1	0
ZNF100	163227	broad.mit.edu	37	19	21909994	21909994	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:21909994T>G	ENST00000358296.6	-	5	1318	c.1120A>C	c.(1120-1122)Aaa>Caa	p.K374Q	ZNF100_ENST00000305570.6_Missense_Mutation_p.K310Q	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	374					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						TCTTCACATTTGTAAGGTTTC	0.388000													6	59					0	0	0.021553	0	0
ZNF638	27332	broad.mit.edu	37	2	71576193	71576193	+	Missense_Mutation	SNP	A	A	G	rs139959335		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:71576193A>G	ENST00000409544.1	+	2	739	c.109A>G	c.(109-111)Atg>Gtg	p.M37V	ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000264447.4_Missense_Mutation_p.M37V|ZNF638_ENST00000355812.3_Missense_Mutation_p.M37V|ZNF638_ENST00000377802.2_Missense_Mutation_p.M37V	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	37					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GCCTGGATCTATGGGTCTCCC	0.507000													25	182					0	0	0.091800	0	0
OR4C12	283093	broad.mit.edu	37	11	50003113	50003113	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:50003113C>A	ENST00000335238.4	-	1	958	c.925G>T	c.(925-927)Gat>Tat	p.D309Y		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D309Y(1)		NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						CTTATTTAATCATTATCTGAA	0.378000													4	16					5.9392e-07	8.06034e-07	0.021553	1	0
ACRBP	84519	broad.mit.edu	37	12	6754460	6754460	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:6754460G>A	ENST00000229243.2	-	4	494	c.401C>T	c.(400-402)aCt>aTt	p.T134I	ACRBP_ENST00000414226.2_Missense_Mutation_p.T134I|ACRBP_ENST00000536350.1_Missense_Mutation_p.T134I	NM_032489.2	NP_115878.2	Q8NEB7	ACRBP_HUMAN	acrosin binding protein	134						acrosomal vesicle|extracellular region				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(8)|lung(5)|ovary(1)	17						CTCCTTGAGAGTGTTAGGTGA	0.532000													5	27					0	0	0.029380	0	0
TTC7B	145567	broad.mit.edu	37	14	91155922	91155922	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:91155922G>T	ENST00000357056.2	-	7	1033	c.912C>A	c.(910-912)taC>taA	p.Y304*	TTC7B_ENST00000328459.6_Nonsense_Mutation_p.Y304*			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	304							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				GAGTGAGAGTGTAGGTTTTTG	0.507000													4	42					0.00909568	0.00989416	0.009096	1	0
SCN5A	6331	broad.mit.edu	37	3	38639328	38639328	+	Silent	SNP	A	A	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:38639328A>G	ENST00000413689.1	-	14	2347	c.2154T>C	c.(2152-2154)ttT>ttC	p.F718F	SCN5A_ENST00000455624.2_Silent_p.F718F|SCN5A_ENST00000450102.2_Silent_p.F718F|SCN5A_ENST00000449557.2_Silent_p.F718F|SCN5A_ENST00000333535.4_Silent_p.F718F|SCN5A_ENST00000451551.2_Silent_p.F718F|SCN5A_ENST00000425664.1_Silent_p.F718F|SCN5A_ENST00000443581.1_Silent_p.F718F|SCN5A_ENST00000423572.2_Silent_p.F718F|SCN5A_ENST00000414099.2_Silent_p.F718F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	718					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGAGGTCAGTAAACGGGTCCA	0.547000													7	59					0	0	0.058154	0	0
ATP10B	23120	broad.mit.edu	37	5	160097613	160097613	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:160097613T>C	ENST00000327245.5	-	7	1378	c.532A>G	c.(532-534)Atg>Gtg	p.M178V		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	178					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TTGCATTTCATTTGGATGAAG	0.488000													20	87					0	0	0.055883	0	0
SPANXN4	441525	broad.mit.edu	37	X	142113848	142113848	+	Silent	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:142113848C>G	ENST00000370504.3	+	1	131	c.48C>G	c.(46-48)ccC>ccG	p.P16P	SPANXN4_ENST00000446864.1_Silent_p.P16P			Q5MJ08	SPXN4_HUMAN	SPANX family, member N4	16										endometrium(2)|large_intestine(2)|lung(3)|ovary(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					TGAAGAGCCCCTGTGAATCTA	0.428000													5	40					0	0	0.029380	0	0
PRDM15	63977	broad.mit.edu	37	21	43248628	43248628	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:43248628G>A	ENST00000422911.1	-	13	1700	c.1599C>T	c.(1597-1599)tcC>tcT	p.S533S	PRDM15_ENST00000538201.1_Silent_p.S496S|PRDM15_ENST00000398548.1_Silent_p.S513S|PRDM15_ENST00000269844.3_Silent_p.S842S|PRDM15_ENST00000447207.2_Silent_p.S476S			P57071	PRD15_HUMAN	PR domain containing 15	842					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TCTTGTGCTTGGAGAGGTTGC	0.507000													6	592					0	0	0.021553	0	0
TMEFF1	8577	broad.mit.edu	37	9	103338824	103338824	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:103338824G>T	ENST00000374879.4	+	10	1517	c.1085G>T	c.(1084-1086)cGt>cTt	p.R362L	MSANTD3-TMEFF1_ENST00000502978.1_Silent_p.T325T|TMEFF1_ENST00000334943.6_Missense_Mutation_p.R323L	NM_003692.4	NP_003683.2			transmembrane protein with EGF-like and two follistatin-like domains 1											NS(1)|kidney(1)|large_intestine(7)|lung(9)|stomach(1)	19		Acute lymphoblastic leukemia(62;0.0452)				AATAGAGGACGTCGACAGAAG	0.328000													8	104					0.000274275	0.000332632	0.047766	1	0
FSCN1	6624	broad.mit.edu	37	7	5644976	5644976	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:5644976C>A	ENST00000382361.3	+	5	1467	c.1353C>A	c.(1351-1353)ttC>ttA	p.F451L	FSCN1_ENST00000340250.6_Missense_Mutation_p.F430L	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	451					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		CTGTGGACTTCTTCTTCGAGT	0.617000													3	12					0.00909568	0.00989416	0.009096	1	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044315	90044315	+	RNA	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:90044315G>T	ENST00000462693.1	+	0	266																											GTTTCTAACCGGTTCTCTGGG	0.507000													8	106					0.00621372	0.00691761	0.058154	1	0
MALT1	10892	broad.mit.edu	37	18	56390406	56390406	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:56390406C>T	ENST00000348428.3	+	10	1403	c.1145C>T	c.(1144-1146)tCa>tTa	p.S382L	RP11-126O1.4_ENST00000588835.1_RNA|MALT1_ENST00000345724.3_Missense_Mutation_p.S371L	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	382	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity	p.S371L(1)		central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						AAAGTGGTTTCACTGTTGGAT	0.393000			T	BIRC3	MALT								4	36					0	0	0.009096	0	0
GAPDH	2597	broad.mit.edu	37	12	6646512	6646512	+	Missense_Mutation	SNP	G	G	T	rs77154254		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:6646512G>T	ENST00000229239.5	+	7	1147	c.481G>T	c.(481-483)Gcc>Tcc	p.A161S	GAPDH_ENST00000396856.1_Missense_Mutation_p.A86S|GAPDH_ENST00000396858.1_Missense_Mutation_p.A119S|GAPDH_ENST00000396859.1_Missense_Mutation_p.A161S|GAPDH_ENST00000396861.1_Missense_Mutation_p.A161S	NM_002046.4	NP_002037.2	P04406	G3P_HUMAN	glyceraldehyde-3-phosphate dehydrogenase	161					gluconeogenesis|glycolysis|neuron apoptosis|peptidyl-cysteine S-trans-nitrosylation|protein stabilization	cytosol|membrane|nucleus|perinuclear region of cytoplasm	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|peptidyl-cysteine S-nitrosylase activity|protein binding	p.A161S(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|lung(4)	7					NADH(DB00157)	AGCACCCCTGGCCAAGGTCAT	0.577000													3	19					0.00024832	0.000303739	0.009096	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68244432	68244432	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:68244432G>T	ENST00000347230.4	-	25	4956	c.4818C>A	c.(4816-4818)gaC>gaA	p.D1606E	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.D1606E	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1606					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		ACATGGTGGGGTCAGGGATTC	0.502000													4	92					1.23904e-05	1.63484e-05	0.014758	1	0
SHROOM4	57477	broad.mit.edu	37	X	50378103	50378103	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:50378103T>C	ENST00000376020.2	-	4	995	c.970A>G	c.(970-972)Agg>Ggg	p.R324G	SHROOM4_ENST00000460112.3_Missense_Mutation_p.R208G|SHROOM4_ENST00000289292.7_Missense_Mutation_p.R324G	NM_020717.3	NP_065768.2	Q9ULL8	SHRM4_HUMAN	shroom family member 4	324					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(6)|liver(1)|lung(20)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	52	Ovarian(276;0.236)					CAACAGAACCTATTAGGGTTC	0.557000													3	40					0	0	0.115264	0	0
PIGP	51227	broad.mit.edu	37	21	38437987	38437987	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:38437987C>A	ENST00000464265.1	-	4	595	c.372G>T	c.(370-372)caG>caT	p.Q124H	PIGP_ENST00000329667.3_5'UTR|PIGP_ENST00000399103.1_Missense_Mutation_p.Q100H|PIGP_ENST00000360525.3_Missense_Mutation_p.Q100H|PIGP_ENST00000399098.1_Missense_Mutation_p.Q74H|PIGP_ENST00000399102.1_Missense_Mutation_p.Q100H	NM_153681.2	NP_710148.1	P57054	PIGP_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class P	124					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			kidney(1)|urinary_tract(1)	2		Myeloproliferative disorder(46;0.0412)				GGTATTTCTTCTGCTGTTGAT	0.373000													9	42					0.00621372	0.00691761	0.058154	1	0
SYS1	90196	broad.mit.edu	37	20	43995536	43995536	+	Silent	SNP	C	C	T	rs142015382		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr20:43995536C>T	ENST00000243918.5	+	4	543	c.252C>T	c.(250-252)ttC>ttT	p.F84F	SYS1-DBNDD2_ENST00000475242.1_Intron|SYS1_ENST00000372727.1_Silent_p.F84F|SYS1_ENST00000479779.1_3'UTR|SYS1_ENST00000426004.1_Intron|SYS1-DBNDD2_ENST00000452133.1_Intron|SYS1_ENST00000414310.1_Silent_p.F63F	NM_033542.3	NP_291020.1	Q8N2H4	SYS1_HUMAN	SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)	84					protein transport	Golgi membrane|integral to membrane		p.F84F(1)		cervix(1)|endometrium(2)|large_intestine(2)|prostate(1)|skin(1)	7		Myeloproliferative disorder(115;0.0122)				TGCTGTACTTCATCCGGCGAG	0.552000													7	90					0	0	0.058154	0	0
SLIT3	6586	broad.mit.edu	37	5	168110989	168110989	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:168110989G>A	ENST00000519560.1	-	32	4087	c.3668C>T	c.(3667-3669)cCt>cTt	p.P1223L	SLIT3_ENST00000332966.8_Missense_Mutation_p.P1230L|SLIT3_ENST00000404867.3_Missense_Mutation_p.P1223L	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1223	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGTGGTTGGAGGGGAACTCAG	0.582000													6	43					0	0	0.021553	0	0
BRF2	55290	broad.mit.edu	37	8	37704409	37704409	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:37704409G>C	ENST00000220659.6	-	3	619	c.499C>G	c.(499-501)Ctg>Gtg	p.L167V	BRF2_ENST00000520601.1_Missense_Mutation_p.L167V	NM_018310.3	NP_060780.2	Q9HAW0	BRF2_HUMAN	BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit	167					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter|transcription initiation, DNA-dependent	nucleoplasm	protein binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(5)|ovary(1)	12		Lung NSC(58;0.118)|all_lung(54;0.195)	BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;1.81e-10)			GCCAAGCACAGAGATGGCACA	0.507000													4	326					0	0	0.014758	0	0
PFAS	5198	broad.mit.edu	37	17	8167643	8167643	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:8167643G>C	ENST00000314666.6	+	16	2038	c.1905G>C	c.(1903-1905)aaG>aaC	p.K635N	PFAS_ENST00000545834.1_Missense_Mutation_p.K211N	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	635					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	TGCTGGGCAAGATGCCTCGGA	0.607000													4	35					0	0	0.014758	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725412	140725412	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:140725412G>T	ENST00000253812.6	+	1	1812	c.1812G>T	c.(1810-1812)ctG>ctT	p.L604L	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCTGGCTGTCCTACCGCC	0.701000													4	24					0.00307968	0.00349685	0.038147	1	0
HIST1H2AB	8335	broad.mit.edu	37	6	26033628	26033628	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:26033628C>T	ENST00000259791.2	-	1	168	c.169G>A	c.(169-171)Gag>Aag	p.E57K		NM_003513.2	NP_003504.2	P04908	H2A1B_HUMAN	histone cluster 1, H2ab	57					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8						GTCAGGTACTCAAGCACCGCC	0.657000													5	33					0	0	0.021553	0	0
OR1E1	8387	broad.mit.edu	37	17	3300975	3300975	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:3300975G>T	ENST00000322608.2	-	1	729	c.730C>A	c.(730-732)Cac>Aac	p.H244N		NM_003553.2	NP_003544.2	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H244N(1)		endometrium(3)|large_intestine(2)|lung(5)	10						ACAGACAGGTGGGAGCCACAA	0.458000													27	101					2.70662e-09	3.91567e-09	0.144211	1	0
NXF3	56000	broad.mit.edu	37	X	102335100	102335100	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:102335100G>A	ENST00000425644.1	-	11	1042	c.44C>T	c.(43-45)cCc>cTc	p.P15L	NXF3_ENST00000497850.1_5'UTR|NXF3_ENST00000395065.3_Silent_p.A324A			Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	0						cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						ACCTCTTGTGGGCTTCAGTAC	0.527000													43	235					0	0	0.131918	0	0
FAM47B	170062	broad.mit.edu	37	X	34961740	34961740	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:34961740C>A	ENST00000329357.5	+	1	828	c.792C>A	c.(790-792)ccC>ccA	p.P264P		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	264	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						CAGAGCCTCCCAAGACTCTGG	0.632000													8	83					3.27435e-08	4.64274e-08	0.119110	1	0
FANCI	55215	broad.mit.edu	37	15	89816700	89816700	+	Splice_Site	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:89816700G>T	ENST00000310775.7	+	11	1061	c.975_splice	c.e11+1	p.Q325_splice	FANCI_ENST00000300027.8_Splice_Site_p.Q325_splice	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	325					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTCAGGACCAGGTATTTTTTT	0.313000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	45					0.000602214	0.000712162	0.014758	1	0
ZNF100	163227	broad.mit.edu	37	19	21909553	21909553	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:21909553C>T	ENST00000358296.6	-	5	1759	c.1561G>A	c.(1561-1563)Gac>Aac	p.D521N	ZNF100_ENST00000305570.6_Missense_Mutation_p.D457N	NM_173531.3	NP_775802.2	Q8IYN0	ZN100_HUMAN	zinc finger protein 100	521					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	21						TGGTTAAAGTCTTTACCACAT	0.373000													3	38					0	0	0.115264	0	0
EFCAB5	374786	broad.mit.edu	37	17	28383151	28383151	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:28383151T>A	ENST00000394835.3	+	12	2534	c.2342T>A	c.(2341-2343)aTc>aAc	p.I781N	EFCAB5_ENST00000394832.2_Missense_Mutation_p.I781N|EFCAB5_ENST00000536908.2_Missense_Mutation_p.I725N|EFCAB5_ENST00000541045.1_Missense_Mutation_p.I438N|EFCAB5_ENST00000378738.3_Missense_Mutation_p.I781N|EFCAB5_ENST00000320856.5_Missense_Mutation_p.I781N	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	781							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GCAAACTTAATCTATGGTAAC	0.343000													6	28					0	0	0.029380	0	0
KRT14	3861	broad.mit.edu	37	17	39740094	39740094	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:39740094C>T	ENST00000167586.6	-	4	931	c.845G>A	c.(844-846)cGc>cAc	p.R282H		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	282	Linker 12.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				GTTCAGAATGCGGCTCAGGTC	0.562000													4	143					0	0	0.009096	0	0
PDCL3	79031	broad.mit.edu	37	2	101188240	101188240	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:101188240G>A	ENST00000264254.6	+	5	935	c.557G>A	c.(556-558)gGc>gAc	p.G186D		NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	186					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding			endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						GTGTTTGGCGGCATGAACCTG	0.498000													4	132					0	0	0.029380	0	0
CDH11	1009	broad.mit.edu	37	16	65005562	65005562	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:65005562G>A	ENST00000394156.3	-	11	2015	c.1562C>T	c.(1561-1563)aCg>aTg	p.T521M	CDH11_ENST00000268603.4_Missense_Mutation_p.T521M|CDH11_ENST00000566827.1_Missense_Mutation_p.T395M			P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	521	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		TCCATTGGCCGTGTCATCCTT	0.403000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			4	63					0	0	0.021553	0	0
RBM12B	389677	broad.mit.edu	37	8	94747019	94747019	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:94747019G>A	ENST00000399300.2	-	3	1833	c.1620C>T	c.(1618-1620)ttC>ttT	p.F540F	RBM12B_ENST00000517700.1_Silent_p.F540F|RBM12B_ENST00000520961.1_Intron	NM_203390.2	NP_976324.2	Q8IXT5	RB12B_HUMAN	RNA binding motif protein 12B	540							nucleotide binding|RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	30	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.0168)			GGGGATGCTTGAAGTTATCCA	0.493000													4	56					0	0	0.009096	0	0
GPR37	2861	broad.mit.edu	37	7	124404556	124404556	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:124404556C>A	ENST00000303921.2	-	1	1125	c.475G>T	c.(475-477)Gct>Tct	p.A159S		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	159						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GAAATGCCAGCGCCTCTGGGA	0.597000													3	44					0.00909568	0.00989416	0.009096	1	0
HUNK	30811	broad.mit.edu	37	21	33347015	33347015	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:33347015C>T	ENST00000270112.2	+	7	1519	c.1159C>T	c.(1159-1161)Cgc>Tgc	p.R387C	HUNK_ENST00000465574.1_3'UTR	NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	387					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						GAAACTGGAGCGCTATTTGTC	0.517000													3	63					0	0	0.014758	0	0
FAM129A	116496	broad.mit.edu	37	1	184764489	184764489	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:184764489G>A	ENST00000367511.3	-	14	2602	c.2409C>T	c.(2407-2409)ctC>ctT	p.L803L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	803	Glu-rich.				negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						GCTCCTCGGTGAGCCCTCCAC	0.677000													7	85					0	0	0.105934	0	0
ATP10D	57205	broad.mit.edu	37	4	47548645	47548645	+	Missense_Mutation	SNP	G	G	C	rs139734817		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:47548645G>C	ENST00000273859.3	+	10	1670	c.1401G>C	c.(1399-1401)agG>agC	p.R467S	ATP10D_ENST00000504445.1_Missense_Mutation_p.R452S	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	467					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CCACAGCCAGGAGGTTGGAGT	0.453000													7	201					0	0	0.038147	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161165358	161165358	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:161165358G>T	ENST00000367996.4	-	4	1586	c.1158C>A	c.(1156-1158)acC>acA	p.T386T	ADAMTS4_ENST00000478394.1_5'UTR	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	386	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CATGGCGAGAGGTGCTCAAAG	0.557000													7	259					5.4927e-09	7.86643e-09	0.047766	1	0
HENMT1	113802	broad.mit.edu	37	1	109193697	109193697	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:109193697T>A	ENST00000370032.5	-	6	953	c.533A>T	c.(532-534)gAt>gTt	p.D178V	HENMT1_ENST00000402983.1_Missense_Mutation_p.D178V|HENMT1_ENST00000493676.1_5'UTR|HENMT1_ENST00000370031.1_Missense_Mutation_p.D178V	NM_144584.2	NP_653185.2	Q5T8I9	HENMT_HUMAN	HEN1 methyltransferase homolog 1 (Arabidopsis)	178					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	16						ATGATCTGAATCTCTTAAGGT	0.398000													14	83					0	0	0.033300	0	0
FAM129B	64855	broad.mit.edu	37	9	130270748	130270748	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:130270748C>A	ENST00000373312.3	-	11	1600	c.1387G>T	c.(1387-1389)Gag>Tag	p.E463*	FAM129B_ENST00000468379.1_Intron|FAM129B_ENST00000373314.3_Nonsense_Mutation_p.E450*	NM_022833.2	NP_073744.2	Q96TA1	NIBL1_HUMAN	family with sequence similarity 129, member B	463							protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CACAGCTCCTCCTTGGTGGGC	0.667000													5	50					0.0293803	0.0307845	0.029380	1	0
GABRB3	2562	broad.mit.edu	37	15	26825498	26825498	+	Missense_Mutation	SNP	C	C	A	rs121913125		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:26825498C>A	ENST00000541819.2	-	7	920	c.818G>T	c.(817-819)cGt>cTt	p.R273L	GABRB3_ENST00000299267.4_Missense_Mutation_p.R217L|GABRB3_ENST00000545868.1_Missense_Mutation_p.R132L|GABRB3_ENST00000400188.3_Missense_Mutation_p.R146L|GABRB3_ENST00000311550.5_Missense_Mutation_p.R217L			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	217					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CGAGACCAGACGGTGCTCCAC	0.557000													14	106					1.49906e-05	1.96881e-05	0.119110	1	0
IGLV2-28	28812	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	7					0	0	0.115264	0	0
TTBK2	146057	broad.mit.edu	37	15	43086859	43086859	+	Silent	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:43086859C>T	ENST00000267890.6	-	10	1071	c.963G>A	c.(961-963)ttG>ttA	p.L321L	TTBK2_ENST00000567840.1_Silent_p.L321L|TTBK2_ENST00000567274.1_Silent_p.L286L	NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	321					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CAGCAGGGGTCAAGCGAGTGT	0.448000													4	70					0	0	0.021553	0	0
PNCK	139728	broad.mit.edu	37	X	152937446	152937446	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:152937446G>T	ENST00000393831.2	-	5	737	c.303C>A	c.(301-303)cgC>cgA	p.R101R	PNCK_ENST00000370142.1_Silent_p.R101R|PNCK_ENST00000370145.4_Silent_p.R118R|PNCK_ENST00000370150.1_Silent_p.R101R|PNCK_ENST00000340888.3_Silent_p.R101R|PNCK_ENST00000447676.2_Silent_p.R184R|PNCK_ENST00000475172.1_5'UTR	NM_001039582.3	NP_001034671.3	Q6P2M8	KCC1B_HUMAN	pregnancy up-regulated nonubiquitous CaM kinase	101	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCTCCATGATGCGGTCAAACA	0.652000													5	41					8.12818e-05	0.000101602	0.029380	1	0
CSRP1	1465	broad.mit.edu	37	1	201465415	201465415	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:201465415C>T	ENST00000367306.1	-	3	380	c.17G>A	c.(16-18)gGa>gAa	p.G6E	CSRP1_ENST00000526723.1_Missense_Mutation_p.G6E|CSRP1_ENST00000531916.1_Missense_Mutation_p.G6E|CSRP1_ENST00000533432.1_Missense_Mutation_p.G6E|CSRP1_ENST00000532460.1_Missense_Mutation_p.G6E|CSRP1_ENST00000340006.2_Missense_Mutation_p.G6E|CSRP1_ENST00000458271.2_5'UTR			P21291	CSRP1_HUMAN	cysteine and glycine-rich protein 1	6						nucleus	zinc ion binding			large_intestine(3)|lung(2)|ovary(1)	6						TTTCTTGCCTCCTCCCCAGTT	0.478000													9	85					0	0	0.058154	0	0
VWA3B	200403	broad.mit.edu	37	2	98797496	98797496	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:98797496G>T	ENST00000477737.1	+	9	1336	c.1132G>T	c.(1132-1134)Gtt>Ttt	p.V378F	VWA3B_ENST00000451075.2_Missense_Mutation_p.V228F|VWA3B_ENST00000435344.1_Missense_Mutation_p.V378F	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	378										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						AACAACCTCTGTTGAGATTGC	0.443000													16	37					4.75885e-15	7.29178e-15	0.033300	1	0
DCST1	149095	broad.mit.edu	37	1	155006927	155006927	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:155006927G>T	ENST00000295542.1	+	3	174	c.78G>T	c.(76-78)ctG>ctT	p.L26L	DCST1_ENST00000368419.2_Silent_p.L26L|DCST1_ENST00000423025.2_Silent_p.L26L|DCST1_ENST00000392480.1_Silent_p.L26L	NM_152494.3	NP_689707.2	Q5T197	DCST1_HUMAN	DC-STAMP domain containing 1	26						integral to membrane	zinc ion binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	27	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			AGAGGCTCCTGACCTGGGGGC	0.647000													7	90					3.86212e-05	4.93589e-05	0.069234	1	0
MRC2	9902	broad.mit.edu	37	17	60741988	60741988	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:60741988G>T	ENST00000303375.5	+	2	600	c.198G>T	c.(196-198)ccG>ccT	p.P66P		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	66	Ricin B-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GAGTCACCCCGGCTTGCAATA	0.632000													4	40					0.014758	0.0158121	0.014758	1	0
IGHV2-5	28457	broad.mit.edu	37	14	106494317	106494317	+	RNA	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:106494317G>T	ENST00000390597.2	-	0	194																											GGGGGCTGACGGATCCAGCCC	0.562000													4	45					5.9392e-07	8.06034e-07	0.021553	1	0
ERRFI1	54206	broad.mit.edu	37	1	8075586	8075586	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:8075586T>G	ENST00000377482.5	-	2	317	c.94A>C	c.(94-96)Acc>Ccc	p.T32P	ERRFI1_ENST00000469499.1_Missense_Mutation_p.T32P|ERRFI1_ENST00000474874.1_Missense_Mutation_p.T32P|ERRFI1_ENST00000467067.1_Missense_Mutation_p.T32P	NM_018948.3	NP_061821.1	Q9UJM3	ERRFI_HUMAN	ERBB receptor feedback inhibitor 1	32					lung alveolus development|lung epithelium development|lung vasculature development|negative regulation of epidermal growth factor receptor activity|negative regulation of protein autophosphorylation|regulation of keratinocyte differentiation|response to stress|skin morphogenesis	cytoplasm|extrinsic to internal side of plasma membrane|nucleus	protein kinase binding|Rho GTPase activator activity			breast(1)|endometrium(2)|large_intestine(3)|liver(3)|lung(3)|ovary(1)|prostate(1)|skin(2)	16	Ovarian(185;0.06)|all_lung(157;0.151)	all_epithelial(116;1.76e-16)|all_lung(118;3.66e-05)|Lung NSC(185;0.000163)|Renal(390;0.000469)|Colorectal(325;0.0033)|Breast(348;0.0044)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.33e-70)|GBM - Glioblastoma multiforme(8;8.05e-37)|Colorectal(212;6.23e-08)|COAD - Colon adenocarcinoma(227;6.9e-06)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTCCAGTAGGTCTTCCTCATA	0.433000													16	143					0	0	0.043863	0	0
DNAH9	1770	broad.mit.edu	37	17	11584180	11584180	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:11584180G>T	ENST00000262442.3	+	19	3785	c.3717G>T	c.(3715-3717)gaG>gaT	p.E1239D	DNAH9_ENST00000454412.2_Missense_Mutation_p.E1239D	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1239	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AATTCTGGGAGCAATTCCACA	0.522000													5	26					5.9392e-07	8.06034e-07	0.021553	1	0
MBOAT1	154141	broad.mit.edu	37	6	20113209	20113209	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:20113209G>A	ENST00000541730.1	-	10	1255	c.660C>T	c.(658-660)ccC>ccT	p.P220P	MBOAT1_ENST00000324607.7_Silent_p.P369P			Q6ZNC8	MBOA1_HUMAN	membrane bound O-acyltransferase domain containing 1	369					phospholipid biosynthetic process	integral to membrane	acyltransferase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(5)	20	all_cancers(95;0.244)|Breast(50;0.0379)|Ovarian(93;0.0473)|all_epithelial(95;0.109)		OV - Ovarian serous cystadenocarcinoma(7;0.00392)|all cancers(50;0.0117)|Epithelial(50;0.0454)			TTAGCACCGTGGGGTACCATG	0.458000													10	54					0	0	0.069234	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203707	140203707	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:140203707G>T	ENST00000529859.1	+	1	2347	c.2347G>T	c.(2347-2349)Gac>Tac	p.D783Y	PCDHA5_ENST00000378126.3_Missense_Mutation_p.D783Y|PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.D783Y	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCTCTACAGACAACGTGAG	0.438000													6	17					0.00116845	0.00136478	0.021553	1	0
TRPM3	80036	broad.mit.edu	37	9	73151377	73151377	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:73151377A>T	ENST00000377110.2	-	25	4859	c.4616T>A	c.(4615-4617)gTa>gAa	p.V1539E	TRPM3_ENST00000396285.1_Missense_Mutation_p.V1398E|TRPM3_ENST00000360823.2_Missense_Mutation_p.V1401E|TRPM3_ENST00000396292.4_Missense_Mutation_p.V1411E|TRPM3_ENST00000357533.2_Missense_Mutation_p.V1543E|TRPM3_ENST00000358082.3_Missense_Mutation_p.V1401E|TRPM3_ENST00000377105.1_Missense_Mutation_p.V1398E|TRPM3_ENST00000377106.1_Missense_Mutation_p.V1411E|TRPM3_ENST00000408909.2_Missense_Mutation_p.V1398E|TRPM3_ENST00000396280.5_Missense_Mutation_p.V1388E|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000423814.3_Missense_Mutation_p.V1566E	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1564						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						TGCTGTTTTTACAGGCACCCC	0.468000													7	67					0	0	0.038147	0	0
SPANXN4	441525	broad.mit.edu	37	X	142113847	142113847	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:142113847C>A	ENST00000370504.3	+	1	130	c.47C>A	c.(46-48)cCc>cAc	p.P16H	SPANXN4_ENST00000446864.1_Missense_Mutation_p.P16H			Q5MJ08	SPXN4_HUMAN	SPANX family, member N4	16										endometrium(2)|large_intestine(2)|lung(3)|ovary(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					ATGAAGAGCCCCTGTGAATCT	0.428000													5	40					8.12818e-05	0.000101602	0.029380	1	0
PDYN	5173	broad.mit.edu	37	20	1961230	1961230	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr20:1961230G>T	ENST00000217305.2	-	4	729	c.504C>A	c.(502-504)ccC>ccA	p.P168P	PDYN_ENST00000540134.1_Silent_p.P168P|RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000539905.1_Silent_p.P168P	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	168					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCTGCTCCTTGGGGTCCTCCT	0.597000													15	118					0.000308642	0.000371152	0.132662	1	0
PYROXD1	79912	broad.mit.edu	37	12	21621465	21621465	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:21621465C>T	ENST00000538582.1	+	12	1820	c.1067C>T	c.(1066-1068)gCa>gTa	p.A356V	PYROXD1_ENST00000240651.9_Missense_Mutation_p.A427V			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	427							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						AAATACAATGCACAGGGCTTA	0.368000													11	42					0	0	0.080935	0	0
ATP1A1	476	broad.mit.edu	37	1	116935540	116935540	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:116935540C>A	ENST00000537345.1	+	11	1760	c.1397C>A	c.(1396-1398)tCc>tAc	p.S466Y	ATP1A1_ENST00000295598.5_Missense_Mutation_p.S466Y|ATP1A1_ENST00000369496.4_Missense_Mutation_p.S435Y	NM_001160233.1	NP_001153705.1	P05023	AT1A1_HUMAN	ATPase, Na+/K+ transporting, alpha 1 polypeptide	466					ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			NS(2)|breast(2)|cervix(3)|endometrium(2)|kidney(5)|large_intestine(9)|lung(17)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	47	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	TGCTGTGGTTCCGTGAAGGAG	0.493000													6	342					0.00198382	0.00227064	0.029380	1	0
MYL3	4634	broad.mit.edu	37	3	46904771	46904771	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:46904771A>C	ENST00000395869.1	-	1	161	c.110T>G	c.(109-111)tTt>tGt	p.F37C	MYL3_ENST00000292327.4_Missense_Mutation_p.F37C			P08590	MYL3_HUMAN	myosin, light chain 3, alkali; ventricular, skeletal, slow	37					cardiac muscle contraction|muscle filament sliding|positive regulation of ATPase activity|regulation of striated muscle contraction|regulation of the force of heart contraction|ventricular cardiac muscle tissue morphogenesis	A band|cytosol|I band|muscle myosin complex	actin monomer binding|calcium ion binding|myosin II heavy chain binding|structural constituent of muscle			breast(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(193;0.00116)|KIRC - Kidney renal clear cell carcinoma(197;0.00557)|Kidney(197;0.0063)		GGAAGCATCAAACTCGACCTC	0.587000													14	108					0	0	0.033300	0	0
HCFC1	3054	broad.mit.edu	37	X	153230086	153230086	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:153230086C>A	ENST00000310441.7	-	2	1251	c.285G>T	c.(283-285)ctG>ctT	p.L95L	HCFC1_ENST00000354233.3_Silent_p.L95L|HCFC1_ENST00000369984.4_Silent_p.L95L	NM_005334.2	NP_005325.2	P51610	HCFC1_HUMAN	host cell factor C1 (VP16-accessory protein)	95					cell cycle|interspecies interaction between organisms|positive regulation of cell cycle|positive regulation of gene expression|protein stabilization|reactivation of latent virus|regulation of protein complex assembly|transcription from RNA polymerase II promoter	mitochondrion|MLL1 complex|MLL5-L complex|Set1C/COMPASS complex	chromatin binding|identical protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(3)|large_intestine(3)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	all_cancers(53;6.23e-16)|all_epithelial(53;5.61e-10)|all_lung(58;3.99e-07)|Lung NSC(58;5.02e-07)|all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACCAAACACCAGGAGGCGAG	0.587000													10	94					2.17888e-05	2.83553e-05	0.058154	1	0
CDCP1	64866	broad.mit.edu	37	3	45153843	45153843	+	Silent	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:45153843G>C	ENST00000296129.1	-	3	521	c.387C>G	c.(385-387)gtC>gtG	p.V129V	CDCP1_ENST00000490471.1_5'UTR|CDCP1_ENST00000425231.2_Silent_p.V129V	NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	129						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TATGAGCTTTGACATCCCAGA	0.532000													7	233					0	0	0.029380	0	0
ZNF71	58491	broad.mit.edu	37	19	57133886	57133886	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:57133886G>T	ENST00000328070.6	+	3	1465	c.1231G>T	c.(1231-1233)Gtg>Ttg	p.V411L		NM_021216.4	NP_067039.1	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	411						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GAAGCCCTACGTGTGCGGCGA	0.652000													21	95					1.66031e-10	2.41422e-10	0.091800	1	0
ZBTB39	9880	broad.mit.edu	37	12	57398384	57398384	+	Silent	SNP	A	A	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:57398384A>G	ENST00000300101.2	-	2	403	c.318T>C	c.(316-318)gcT>gcC	p.A106A		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	106					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						CCAGACGCTCAGCTACCTCGT	0.537000													20	129					0	0	0.076483	0	0
OR4D10	390197	broad.mit.edu	37	11	59245601	59245601	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:59245601G>T	ENST00000530162.1	+	1	756	c.699G>T	c.(697-699)agG>agT	p.R233S		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAGAGGGCAGGAGGAAAGCCA	0.537000													12	89					3.27435e-08	4.64274e-08	0.119110	1	0
TDP1	55775	broad.mit.edu	37	14	90429629	90429629	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:90429629G>C	ENST00000335725.4	+	3	421	c.171G>C	c.(169-171)aaG>aaC	p.K57N	TDP1_ENST00000555565.1_Intron|TDP1_ENST00000555880.1_Missense_Mutation_p.K57N|TDP1_ENST00000393452.3_Missense_Mutation_p.K57N|TDP1_ENST00000357382.3_5'UTR|TDP1_ENST00000393454.2_Missense_Mutation_p.K57N	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	57					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		CTGCACACAAGAGGAAAATAT	0.507000								Repair of DNA-protein crosslinks					3	120					0	0	0.115264	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129010	248129010	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:248129010A>T	ENST00000366480.3	+	1	476	c.377A>T	c.(376-378)gAa>gTa	p.E126V	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GGTGGAACTGAAGCCCTTCTC	0.448000													34	271					0	0	0.086207	0	0
KCNT2	343450	broad.mit.edu	37	1	196250087	196250087	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:196250087C>G	ENST00000367433.5	-	24	2842	c.2741G>C	c.(2740-2742)aGa>aCa	p.R914T	KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.R938T|KCNT2_ENST00000367431.4_Missense_Mutation_p.R864T|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	938						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.R938I(1)		NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GGCATAAGTTCTGATCCATAA	0.343000													6	16					0	0	0.021553	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23886493	23886493	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:23886493G>C	ENST00000264867.2	-	2	235	c.116C>G	c.(115-117)tCt>tGt	p.S39C	PPARGC1A_ENST00000507380.1_Missense_Mutation_p.S39C	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	39					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding	p.S39C(1)		central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				ATCTAGTTCAGAAAGATCAAG	0.428000													3	66					0	0	0.115264	0	0
LSMEM1	286006	broad.mit.edu	37	7	112124917	112124917	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:112124917G>C	ENST00000312849.4	+	2	407	c.46G>C	c.(46-48)Gat>Cat	p.D16H	LSMEM1_ENST00000439068.2_Missense_Mutation_p.D16H|LSMEM1_ENST00000429049.1_Missense_Mutation_p.D16H	NM_182597.2	NP_872403.1			leucine-rich single-pass membrane protein 1																		CATTCAGGAAGATGGAAAGCT	0.453000													14	94					0	0	0.132662	0	0
TAF1	6872	broad.mit.edu	37	X	70602999	70602999	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:70602999C>G	ENST00000449580.1	+	12	1980	c.1929C>G	c.(1927-1929)atC>atG	p.I643M	TAF1_ENST00000276072.3_Missense_Mutation_p.I664M|TAF1_ENST00000373790.4_Missense_Mutation_p.I643M|TAF1_ENST00000423759.1_Missense_Mutation_p.I664M			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	643					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				TAAAGCACATCAAAAAAAAGG	0.403000													7	49					0	0	0.047766	0	0
TAGAP	117289	broad.mit.edu	37	6	159463138	159463138	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:159463138T>G	ENST00000367066.3	-	5	618	c.287A>C	c.(286-288)gAc>gCc	p.D96A	RP1-111C20.4_ENST00000607391.1_RNA|TAGAP_ENST00000326965.6_Intron|RP1-111C20.4_ENST00000606466.1_RNA|RP1-111C20.4_ENST00000607796.1_RNA|TAGAP_ENST00000338313.5_Missense_Mutation_p.D96A|RP1-111C20.4_ENST00000606470.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	96	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TGTGTCACTGTCACCGCAGAT	0.468000													4	201					0	0	0.014758	0	0
COL2A1	1280	broad.mit.edu	37	12	48369122	48369122	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:48369122G>A	ENST00000380518.3	-	51	4028	c.3864C>T	c.(3862-3864)ctC>ctT	p.L1288L	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Silent_p.L1219L	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1288	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CAGGGTGGCAGAGTTTCAGGT	0.597000													6	35					0	0	0.058154	0	0
LARP4	113251	broad.mit.edu	37	12	50869442	50869442	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:50869442C>T	ENST00000398473.2	+	16	2082	c.1970C>T	c.(1969-1971)cCt>cTt	p.P657L	LARP4_ENST00000293618.8_Missense_Mutation_p.P586L|LARP4_ENST00000518444.1_Missense_Mutation_p.P656L|LARP4_ENST00000347328.5_Missense_Mutation_p.P586L|LARP4_ENST00000429001.3_Missense_Mutation_p.P663L	NM_052879.4|NM_199188.2	NP_443111.4|NP_954658.2	Q71RC2	LARP4_HUMAN	La ribonucleoprotein domain family, member 4	657							nucleotide binding|RNA binding			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(1)|skin(2)|urinary_tract(1)	23						AATGGAGCTCCTGAGAACTCC	0.507000													8	76					0	0	0.047766	0	0
TACR3	6870	broad.mit.edu	37	4	104640714	104640714	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:104640714C>A	ENST00000304883.2	-	1	259	c.119G>T	c.(118-120)gGg>gTg	p.G40V		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	40						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TTGCAGCCACCCAGTCTCAAC	0.697000													4	29					0.000157383	0.000194174	0.038147	1	0
RHBDL3	162494	broad.mit.edu	37	17	30643270	30643270	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:30643270G>T	ENST00000269051.4	+	8	916	c.902G>T	c.(901-903)tGc>tTc	p.C301F	RHBDL3_ENST00000538145.1_Missense_Mutation_p.C293F|RHBDL3_ENST00000536287.1_Missense_Mutation_p.C203F	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	301					proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				GGCATGAAGTGCCAGTTCAAG	0.522000													28	154					7.26314e-15	1.10695e-14	0.125774	1	0
CDH13	1012	broad.mit.edu	37	16	83704557	83704557	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:83704557G>T	ENST00000566620.1	+	9	1554	c.1264G>T	c.(1264-1266)Ggg>Tgg	p.G422W	CDH13_ENST00000428848.3_Missense_Mutation_p.G383W|CDH13_ENST00000268613.10_Missense_Mutation_p.G469W	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	422	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		AACCAACGAAGGGATGCTTTC	0.532000													33	236					3.93418e-24	6.0937e-24	0.069456	1	0
ZNF711	7552	broad.mit.edu	37	X	84526774	84526774	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:84526774C>A	ENST00000360700.4	+	10	3250	c.2364C>A	c.(2362-2364)ttC>ttA	p.F788L	ZNF711_ENST00000373165.3_Missense_Mutation_p.F742L|ZNF711_ENST00000395402.1_Missense_Mutation_p.F750L|ZNF711_ENST00000276123.3_Missense_Mutation_p.F742L|ZNF711_ENST00000542798.1_Missense_Mutation_p.F584L			Q9Y462	ZN711_HUMAN	zinc finger protein 711	742					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						AGAAGGGATTCCGAAGACCAT	0.363000													11	54					0.0135373	0.0146697	0.093190	1	0
ORC3	23595	broad.mit.edu	37	6	88299900	88299900	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:88299900C>T	ENST00000392844.3	+	1	62	c.14C>T	c.(13-15)tCg>tTg	p.S5L	ORC3_ENST00000257789.4_Missense_Mutation_p.S5L|ORC3_ENST00000417380.2_5'UTR|ORC3_ENST00000546266.1_5'UTR	NM_012381.3|NM_181837.2	NP_036513.2|NP_862820.1	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3	5					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	28						GCTACGTCCTCGATGTCTAAG	0.587000													10	62					0	0	0.093190	0	0
PSME2	5721	broad.mit.edu	37	14	24615758	24615758	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:24615758C>A	ENST00000216802.5	-	1	672	c.33G>T	c.(31-33)ggG>ggT	p.G11G	PSME2_ENST00000560410.1_Silent_p.G11G|PSME2_ENST00000471700.2_5'UTR	NM_002818.2	NP_002809.2	Q9UL46	PSME2_HUMAN	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	11					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome activator complex				endometrium(1)|lung(3)|prostate(2)	6				GBM - Glioblastoma multiforme(265;0.00839)		TGCGGGCTTCCCCGCTCAGGC	0.627000													4	32					0.00909568	0.00989416	0.009096	1	0
FCRL3	115352	broad.mit.edu	37	1	157665171	157665171	+	Silent	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:157665171T>A	ENST00000368184.3	-	8	1650	c.1359A>T	c.(1357-1359)gcA>gcT	p.A453A	FCRL3_ENST00000368186.5_Silent_p.A453A|FCRL3_ENST00000473231.1_5'UTR|RP11-367J7.3_ENST00000453692.1_RNA	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	453	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GGCCATTGTCTGCATCACAGG	0.532000													56	210					0	0	0.139131	0	0
CD34	947	broad.mit.edu	37	1	208072455	208072455	+	Missense_Mutation	SNP	C	C	T	rs146237257	byFrequency	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:208072455C>T	ENST00000356522.4	-	3	700	c.379G>A	c.(379-381)Gtt>Att	p.V127I	CD34_ENST00000310833.7_Missense_Mutation_p.V127I|CD34_ENST00000485761.1_5'UTR|CD34_ENST00000537704.1_Intron	NM_001773.2	NP_001764.1	P28906	CD34_HUMAN	CD34 molecule	127					cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						GGAGTTGAAACGTTGGCTGGG	0.473000													11	233					0	0	0.069234	0	0
ZDHHC2	51201	broad.mit.edu	37	8	17055906	17055906	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:17055906G>C	ENST00000262096.8	+	6	1155	c.460G>C	c.(460-462)Gat>Cat	p.D154H		NM_016353.4	NP_057437.1	Q9UIJ5	ZDHC2_HUMAN	zinc finger, DHHC-type containing 2	154						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|pancreas(1)|stomach(1)	8				Colorectal(111;0.0697)|COAD - Colon adenocarcinoma(73;0.244)		TTTGAAGATGGATCATCATTG	0.264000													3	36					0	0	0.115264	0	0
EP300	2033	broad.mit.edu	37	22	41573107	41573107	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:41573107G>T	ENST00000263253.7	+	31	6611	c.5392G>T	c.(5392-5394)Gag>Tag	p.E1798*	RP1-85F18.5_ENST00000420537.1_RNA|RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1798	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						GCACTGCCAGGAGAACAAATG	0.572000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				4	115					0.000602214	0.000712162	0.014758	1	0
ARID4B	51742	broad.mit.edu	37	1	235338529	235338529	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:235338529G>T	ENST00000264183.3	-	22	4131	c.3634C>A	c.(3634-3636)Ccc>Acc	p.P1212T	ARID4B_ENST00000349213.3_Missense_Mutation_p.P1126T|ARID4B_ENST00000366603.2_Missense_Mutation_p.P1212T	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	1212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TAAACTTTGGGTAATCGATTA	0.373000													17	107					4.35082e-09	6.26254e-09	0.055883	1	0
PAX3	5077	broad.mit.edu	37	2	223066780	223066780	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:223066780G>C	ENST00000350526.4	-	8	1439	c.1303C>G	c.(1303-1305)Cat>Gat	p.H435D	PAX3_ENST00000464706.1_5'UTR|PAX3_ENST00000344493.4_Intron|PAX3_ENST00000336840.6_Intron|PAX3_ENST00000392070.2_Missense_Mutation_p.H435D|PAX3_ENST00000392069.2_Missense_Mutation_p.H435D|PAX3_ENST00000409551.3_Missense_Mutation_p.H434D	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	435					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCTTCATATGGTCTAGTCTC	0.562000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						3	44					0	0	0.014758	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16812637	16812637	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:16812637G>A	ENST00000355661.3	-	20	2865	c.2855C>T	c.(2854-2856)tCt>tTt	p.S952F	PLEKHA7_ENST00000531066.1_Missense_Mutation_p.S952F|PLEKHA7_ENST00000332954.4_5'UTR|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.S953F|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	952					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GCCCCGCACAGATGTGTGCCG	0.682000													6	18					0	0	0.029380	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745944	77745944	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:77745944T>C	ENST00000409088.3	-	3	1465	c.1051A>G	c.(1051-1053)Agt>Ggt	p.S351G	LRRTM4_ENST00000409282.1_Missense_Mutation_p.S352G|LRRTM4_ENST00000409093.1_Missense_Mutation_p.S351G|LRRTM4_ENST00000409884.1_Missense_Mutation_p.S351G|LRRTM4_ENST00000409911.1_Missense_Mutation_p.S352G	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	351	LRRCT.					integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		ACTGCATCACTAACCTTTTCA	0.418000													3	16					0	0	0.009096	0	0
HKDC1	80201	broad.mit.edu	37	10	71000488	71000488	+	Nonsense_Mutation	SNP	C	C	A	rs144034774		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:71000488C>A	ENST00000354624.5	+	6	805	c.672C>A	c.(670-672)tgC>tgA	p.C224*	HKDC1_ENST00000395086.2_Nonsense_Mutation_p.C224*	NM_025130.3	NP_079406.3	Q2TB90	HKDC1_HUMAN	hexokinase domain containing 1	224					glycolysis	mitochondrion|nucleus	ATP binding|hexokinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(11)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						ACCCCTACTGCGAAGTTGGTG	0.527000													5	52					8.12818e-05	0.000101602	0.029380	1	0
FPR1	2357	broad.mit.edu	37	19	52249646	52249646	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:52249646C>T	ENST00000595042.1	-	3	743	c.602G>A	c.(601-603)aGa>aAa	p.R201K	FPR1_ENST00000304748.4_Missense_Mutation_p.R201K	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	201					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	GATGATGCCTCTCACCGTCAA	0.507000													21	102					0	0	0.144211	0	0
CPZ	8532	broad.mit.edu	37	4	8607717	8607717	+	Splice_Site	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:8607717G>A	ENST00000382480.2	+	5	1100	c.298_splice	c.e5-1	p.M100_splice	CPZ_ENST00000429646.2_5'UTR|CPZ_ENST00000315782.6_Splice_Site_p.M226_splice|CPZ_ENST00000360986.4_Splice_Site_p.M237_splice	NM_001014448.2	NP_001014448.1	Q66K79	CBPZ_HUMAN	carboxypeptidase Z	237	FZ.				proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TGCCCCCAGTGGAGCCCGAGG	0.602000													4	32					0	0	0.009096	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54604068	54604068	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:54604068G>A	ENST00000474759.1	+	8	873	c.825G>A	c.(823-825)gcG>gcA	p.A275A	CACNA2D3_ENST00000288197.5_Silent_p.A275A|CACNA2D3_ENST00000415676.2_Silent_p.A275A|CACNA2D3_ENST00000490478.1_Silent_p.A181A	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	275	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TGACTATCGCGAAGCAAACAG	0.473000													15	67					0	0	0.132662	0	0
OR2B11	127623	broad.mit.edu	37	1	247615096	247615096	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:247615096C>A	ENST00000318749.6	-	1	212	c.189G>T	c.(187-189)atG>atT	p.M63I		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGAAGATGTACATGGGGCTGT	0.567000													77	170					5.82064e-54	9.11474e-54	0.139131	1	0
NUTM1	256646	broad.mit.edu	37	15	34647923	34647923	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:34647923C>A	ENST00000537011.1	+	8	2096	c.1714C>A	c.(1714-1716)Cta>Ata	p.L572I	NUTM1_ENST00000333756.4_Missense_Mutation_p.L544I|NUTM1_ENST00000438749.3_Missense_Mutation_p.L562I					NUT midline carcinoma, family member 1																		GGAGCAAGCCCTAGATAGCCC	0.617000													19	109					2.21704e-12	3.32555e-12	0.076483	1	0
CEACAM7	1087	broad.mit.edu	37	19	42187792	42187792	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:42187792G>A	ENST00000006724.3	-	3	831	c.630C>T	c.(628-630)gaC>gaT	p.D210D	CEACAM7_ENST00000602225.1_Intron|CEACAM7_ENST00000401731.1_Silent_p.D210D|CEACAM7_ENST00000338196.4_Intron	NM_006890.3	NP_008821.1	Q14002	CEAM7_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 7	210	Ig-like C2-type.					anchored to membrane|integral to membrane|plasma membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.0027)|all cancers(3;0.00979)|Epithelial(262;0.0366)		AGGGTCCTATGTCATTCTTTG	0.537000													48	130					0	0	0.131918	0	0
EP300	2033	broad.mit.edu	37	22	41572505	41572505	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:41572505G>A	ENST00000263253.7	+	30	6253	c.5034G>A	c.(5032-5034)gaG>gaA	p.E1678E	RP1-85F18.5_ENST00000420537.1_RNA|RP1-85F18.6_ENST00000415054.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1678	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						ACCATGTGGAGACACGCTGGC	0.587000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				10	91					0	0	0.069234	0	0
SLC36A1	206358	broad.mit.edu	37	5	150867731	150867731	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:150867731G>T	ENST00000243389.3	+	11	1570	c.1347G>T	c.(1345-1347)gtG>gtT	p.V449V	SLC36A1_ENST00000520701.1_Silent_p.V449V	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	449				VV -> GG (in Ref. 2; AAP47194).	cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TGGGCTTTGTGGTGGGGACCT	0.552000													12	70					0.00136819	0.0015851	0.093190	1	0
PKP4	8502	broad.mit.edu	37	2	159517892	159517892	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:159517892G>T	ENST00000389757.3	+	13	2266	c.2141G>T	c.(2140-2142)tGc>tTc	p.C714F	AC005042.4_ENST00000342892.4_RNA|PKP4_ENST00000389759.3_Missense_Mutation_p.C714F	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	714					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						ATGCGGTCCTGCGAGGGGCTG	0.577000										HNSCC(62;0.18)			5	53					0.000602214	0.000712162	0.014758	1	0
MT-CO2	4513	broad.mit.edu	37	MT	7850	7850	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrM:7850G>A	ENST00000361739.1	+	1	265	c.265G>A	c.(265-267)Gag>Aag	p.E89K						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						ACATAACAGACGAGGTCAACG	0.502000													20	862					0	0	0.069288	0	0
OAS3	4940	broad.mit.edu	37	12	113385773	113385773	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:113385773G>C	ENST00000228928.7	+	5	1077	c.898G>C	c.(898-900)Gac>Cac	p.D300H	RP1-71H24.1_ENST00000552784.1_RNA	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	300	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						GGACCCAGCTGACCCCACATG	0.572000													4	22					0	0	0.014758	0	0
UNC80	285175	broad.mit.edu	37	2	210642159	210642159	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:210642159G>T	ENST00000439458.1	+	4	556	c.476G>T	c.(475-477)gGg>gTg	p.G159V	UNC80_ENST00000272845.5_Missense_Mutation_p.G159V|UNC80_ENST00000478701.1_3'UTR	NM_032504.1	NP_115893.1	Q8N2C7	UNC80_HUMAN	unc-80 homolog (C. elegans)	159						integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)	20						GGTTCTCCAGGGCAGCCTTGC	0.522000													19	93					0.00121646	0.00141507	0.049695	1	0
UBE2NL	389898	broad.mit.edu	37	X	142967318	142967318	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:142967318T>A	ENST00000370494.1	+	1	146	c.116T>A	c.(115-117)aTt>aAt	p.I39N		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	39							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					CATGTGGTCATTGCTGGGGAA	0.478000													23	94					0	0	0.091800	0	0
IGHV4-31	28396	broad.mit.edu	37	14	106805362	106805362	+	RNA	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:106805362C>A	ENST00000438142.2	-	0	272																											ACCCAATCCACTCCAGGCCCT	0.547000													18	249					7.45023e-12	1.11168e-11	0.055883	1	0
ZNF142	7701	broad.mit.edu	37	2	219509519	219509519	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:219509519G>A	ENST00000411696.2	-	7	2499	c.1720C>T	c.(1720-1722)Cac>Tac	p.H574Y	ZNF142_ENST00000449707.1_Missense_Mutation_p.H574Y			P52746	ZN142_HUMAN	zinc finger protein 142	574					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGGGCACAGTGGAACTCACGG	0.582000													3	38					0	0	0.009096	0	0
LRRN3	54674	broad.mit.edu	37	7	110763928	110763928	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:110763928G>T	ENST00000451085.1	+	4	2146	c.1100G>T	c.(1099-1101)aGt>aTt	p.S367I	IMMP2L_ENST00000452895.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.S367I|LRRN3_ENST00000422987.3_Missense_Mutation_p.S367I|IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000331762.3_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000405709.2_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	367						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		AGCATACACAGTAACCCCATC	0.483000													4	43					1.024e-07	1.43764e-07	0.014758	1	0
TMC2	117532	broad.mit.edu	37	20	2616585	2616585	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr20:2616585T>A	ENST00000358864.1	+	18	2335	c.2320T>A	c.(2320-2322)Tac>Aac	p.Y774N		NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	774						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						GGCCATTTACTACCTGAACTC	0.507000													15	49					0	0	0.146539	0	0
TRAV34	28648	broad.mit.edu	37	14	22675815	22675815	+	RNA	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:22675815T>A	ENST00000390461.2	+	0	139																											CACCATAAACTGCACGTCATC	0.418000													8	57					0	0	0.038147	0	0
IGSF10	285313	broad.mit.edu	37	3	151164577	151164577	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:151164577C>A	ENST00000282466.3	-	4	3191	c.3192G>T	c.(3190-3192)ctG>ctT	p.L1064L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1064					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GAAGACAGGACAGACATGTCA	0.502000													13	67					5.50884e-06	7.37098e-06	0.093190	1	0
OR2V2	285659	broad.mit.edu	37	5	180582495	180582495	+	Silent	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:180582495T>C	ENST00000328275.1	+	1	553	c.553T>C	c.(553-555)Ttg>Ctg	p.L185L		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGCTATCCTTGTTGAAGCT	0.463000													13	137					0	0	0.093190	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161165357	161165357	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:161165357A>G	ENST00000367996.4	-	4	1587	c.1159T>C	c.(1159-1161)Tct>Cct	p.S387P	ADAMTS4_ENST00000478394.1_5'UTR	NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	387	Peptidase M12B.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			ACATGGCGAGAGGTGCTCAAA	0.552000													7	258					0	0	0.047766	0	0
ALG13	79868	broad.mit.edu	37	X	110988105	110988105	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:110988105G>C	ENST00000394780.3	+	24	2917	c.2905G>C	c.(2905-2907)Gat>Cat	p.D969H	ALG13_ENST00000251943.4_Intron|ALG13_ENST00000470971.1_3'UTR	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	969	Pro-rich.				dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						TTATTCCTGTGATCCAAGCGG	0.468000													3	37					0	0	0.014758	0	0
GOLGA2	2801	broad.mit.edu	37	9	131019381	131019381	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:131019381C>T	ENST00000421699.2	-	26	2986	c.2974G>A	c.(2974-2976)Gac>Aac	p.D992N		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	992						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						TCATTCTCGTCAGCCCGGTAA	0.557000													17	166					0	0	0.043863	0	0
ATP9B	374868	broad.mit.edu	37	18	77097342	77097342	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:77097342G>A	ENST00000426216.2	+	19	2193	c.2176G>A	c.(2176-2178)Gag>Aag	p.E726K	ATP9B_ENST00000543761.1_Missense_Mutation_p.E47K|ATP9B_ENST00000307671.7_Missense_Mutation_p.E726K	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	726					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		CGCGGTAGTCGAGAGCCTGGA	0.662000													7	35					0	0	0.029380	0	0
CHD3	1107	broad.mit.edu	37	17	7803982	7803982	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:7803982G>A	ENST00000380358.4	+	18	3089	c.3088G>A	c.(3088-3090)Gat>Aat	p.D1030N	CHD3_ENST00000358181.4_Missense_Mutation_p.D971N|CHD3_ENST00000330494.7_Missense_Mutation_p.D971N	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	971					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				ACTCAAGGCAGATGTCTTTAA	0.532000													20	109					0	0	0.076483	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11391	11391	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrM:11391G>A	ENST00000361381.2	+	1	632	c.632G>A	c.(631-633)gGa>gAa	p.211_211insE						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						ACCTCTTTACGGACTCCACTT	0.433000													59	531					0	0	0.139131	0	0
POM121L2	94026	broad.mit.edu	37	6	27278064	27278064	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:27278064G>C	ENST00000444565.1	-	1	1885	c.1886C>G	c.(1885-1887)gCc>gGc	p.A629G	POM121L2_ENST00000377451.2_Missense_Mutation_p.A565G	NM_033482.3	NP_258443.2	C9J1I7	C9J1I7_HUMAN	POM121 transmembrane nucleoporin-like 2	629										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	7						AGATGTGCTGGCTAGGGTGGT	0.498000													3	7					0	0	0.009096	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27537635	27537635	+	RNA	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:27537635G>A	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							TTTTATTGCAGGATAAATCTA	0.338000													7	33					0	0	0.029380	0	0
RBM11	54033	broad.mit.edu	37	21	15599378	15599378	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:15599378G>T	ENST00000400577.3	+	5	619	c.610G>T	c.(610-612)Gct>Tct	p.A204S	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	204							nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		TCAGATGACAGCTCCACTTCC	0.463000													22	185					1.1804e-14	1.78943e-14	0.091800	1	0
MMP1	4312	broad.mit.edu	37	11	102667843	102667843	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:102667843A>G	ENST00000315274.6	-	3	468	c.401T>C	c.(400-402)aTt>aCt	p.I134T	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	134	Metalloprotease.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		GGCTTTCTCAATGGCATGGTC	0.438000													14	67					0	0	0.119110	0	0
ANKRD36BP2	645784	broad.mit.edu	37	2	89100645	89100645	+	RNA	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:89100645C>A	ENST00000393525.3	+	0	1119																											ACAAAGCTGACAATCAAGAAA	0.373000													3	42					0.115264	0.118593	0.115264	1	0
MUC16	94025	broad.mit.edu	37	19	9073841	9073841	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:9073841T>C	ENST00000397910.4	-	3	13808	c.13605A>G	c.(13603-13605)atA>atG	p.I4535M		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4537	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGCTTTGTTTATGGAAGGAT	0.453000													10	119					0	0	0.132662	0	0
ABCB11	8647	broad.mit.edu	37	2	169787280	169787280	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:169787280C>A	ENST00000263817.6	-	25	3430	c.3306G>T	c.(3304-3306)tcG>tcT	p.S1102S		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	1102	ABC transporter 2.				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	CTGGACTAATCGACACTGAGA	0.458000													5	68					0.0293803	0.0307845	0.029380	1	0
KIF4A	24137	broad.mit.edu	37	X	69595967	69595967	+	Silent	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:69595967G>T	ENST00000374403.3	+	18	2023	c.1941G>T	c.(1939-1941)cgG>cgT	p.R647R	KIF4A_ENST00000374388.3_Silent_p.R647R	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	647					anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						AAAACCAGCGGGTACAGTTAA	0.358000													10	42					0.000673444	0.000793106	0.069234	1	0
SLCO1A2	6579	broad.mit.edu	37	12	21453282	21453282	+	Splice_Site	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:21453282C>G	ENST00000307378.6	-	9	1630	c.910_splice	c.e9+1	p.D304_splice	SLCO1A2_ENST00000390670.3_Splice_Site_p.D302_splice|SLCO1A2_ENST00000452078.1_Splice_Site_p.D304_splice|SLCO1A2_ENST00000537524.1_Splice_Site_p.D172_splice|SLCO1A2_ENST00000458504.1_Splice_Site_p.D172_splice	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	304					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						GTATATTTGCCTTTAGTGATT	0.299000													3	18					0	0	0.115264	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182920510	182920510	+	Silent	SNP	A	A	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:182920510A>G	ENST00000367547.3	-	2	734	c.498T>C	c.(496-498)agT>agC	p.S166S	SHCBP1L_ENST00000488956.1_5'UTR|SHCBP1L_ENST00000423786.1_Silent_p.S47S	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	238										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						CAAAGAATACACTGGGATTAG	0.328000													6	21					0	0	0.029380	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092880	151092880	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:151092880C>A	ENST00000370335.1	+	3	1011	c.744C>A	c.(742-744)acC>acA	p.T248T	MAGEA4_ENST00000370340.3_Silent_p.T248T|MAGEA4_ENST00000370337.4_Silent_p.T248T|MAGEA4_ENST00000276344.2_Silent_p.T248T|MAGEA4_ENST00000360243.2_Silent_p.T248T|MAGEA4_ENST00000393920.1_Silent_p.T248T|MAGEA4_ENST00000393921.1_Silent_p.T248T			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	248	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AACTGCTCACCCAAGATTGGG	0.582000													3	33					0.115264	0.118593	0.115264	1	0
EIF2AK4	440275	broad.mit.edu	37	15	40259689	40259689	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:40259689G>T	ENST00000263791.5	+	9	1205	c.1162G>T	c.(1162-1164)Gct>Tct	p.A388S	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.A388S|EIF2AK4_ENST00000559624.1_Missense_Mutation_p.A388S	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	388	Protein kinase 1.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GGTCTCTCTTGCTGCACACCT	0.512000													6	88					0.00621372	0.00691761	0.058154	1	0
MYO1E	4643	broad.mit.edu	37	15	59553679	59553679	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:59553679G>A	ENST00000288235.4	-	3	576	c.177C>T	c.(175-177)gtC>gtT	p.V59V	MYO1E_ENST00000558814.1_Intron	NM_004998.3	NP_004989.2	Q12965	MYO1E_HUMAN	myosin IE	59	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(6)|lung(10)|pancreas(2)|prostate(1)|urinary_tract(1)	33				all cancers(107;0.207)		TGAAAGGGTTGACTGAGATTA	0.343000													8	98					0	0	0.038147	0	0
GRM1	2911	broad.mit.edu	37	6	146350825	146350825	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:146350825C>A	ENST00000392299.2	+	2	642	c.172C>A	c.(172-174)Ccg>Acg	p.P58T	GRM1_ENST00000507907.1_Missense_Mutation_p.P58T|GRM1_ENST00000361719.2_Missense_Mutation_p.P58T|GRM1_ENST00000282753.1_Missense_Mutation_p.P58T|GRM1_ENST00000355289.4_Missense_Mutation_p.P58T|GRM1_ENST00000492807.2_Missense_Mutation_p.P58T			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	58					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TCACCAGCCTCCGGCCGAGAA	0.582000													10	46					9.31168e-06	1.24011e-05	0.105934	1	0
THY1	7070	broad.mit.edu	37	11	119290907	119290907	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:119290907G>T	ENST00000284240.5	-	3	1266	c.227C>A	c.(226-228)tCc>tAc	p.S76Y	USP2-AS1_ENST00000578923.1_RNA|USP2-AS1_ENST00000530002.1_RNA|THY1_ENST00000528522.1_Missense_Mutation_p.S76Y|USP2-AS1_ENST00000500970.1_RNA|THY1_ENST00000527590.1_5'UTR|THY1_ENST00000580275.1_Missense_Mutation_p.S59Y|USP2-AS1_ENST00000498979.2_RNA	NM_006288.3	NP_006279.2	P04216	THY1_HUMAN	Thy-1 cell surface antigen	76	Ig-like V-type.				angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		GTTGGTTCGGGAGCGGTATGT	0.547000													16	83					1.2644e-06	1.70784e-06	0.055883	1	0
OR4A15	81328	broad.mit.edu	37	11	55135511	55135511	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:55135511G>A	ENST00000314706.3	+	1	152	c.152G>A	c.(151-153)gGg>gAg	p.G51E		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	51					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						AACCCTGAGGGGCAAAAGGTT	0.448000													8	36					0	0	0.047766	0	0
AMER1	139285	broad.mit.edu	37	X	63412038	63412038	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:63412038C>T	ENST00000330258.3	-	2	1401	c.1129G>A	c.(1129-1131)Gat>Aat	p.D377N	AMER1_ENST00000403336.1_Missense_Mutation_p.D377N|AMER1_ENST00000374869.3_Missense_Mutation_p.D377N	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									tcGTCATCATCATCTGGCAAG	0.527000													26	151					0	0	0.108266	0	0
OCA2	4948	broad.mit.edu	37	15	28000612	28000612	+	Silent	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:28000612G>C	ENST00000354638.3	-	24	2594	c.2439C>G	c.(2437-2439)ggC>ggG	p.G813G	OCA2_ENST00000353809.5_Silent_p.G789G	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	813					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TCATTGGGAAGCCCAGCCTGA	0.448000									Oculocutaneous Albinism				10	58					0	0	0.093190	0	0
OR51G2	81282	broad.mit.edu	37	11	4936450	4936450	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:4936450C>A	ENST00000322013.3	-	1	472	c.444G>T	c.(442-444)agG>agT	p.R148S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005238.1	NP_001005238.1	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G, member 2	148					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|large_intestine(9)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCAGGCCAATCCTGCCAATGA	0.483000													6	24					3.59834e-05	4.66148e-05	0.021553	1	0
IL7R	3575	broad.mit.edu	37	5	35874618	35874618	+	Silent	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:35874618C>A	ENST00000303115.3	+	6	903	c.774C>A	c.(772-774)atC>atA	p.I258I	IL7R_ENST00000343305.4_Intron|IL7R_ENST00000506850.1_Intron	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	258					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGTTGGTCATCTTGGCCTGTG	0.428000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						6	30					0.00198382	0.00227064	0.029380	1	0
PRF1	5551	broad.mit.edu	37	10	72358889	72358889	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:72358889G>A	ENST00000441259.1	-	3	748	c.588C>T	c.(586-588)gcC>gcT	p.A196A	PRF1_ENST00000373209.2_Silent_p.A196A	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	196	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GGTCCCCGAGGGCCCTCTTGA	0.622000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				4	13					0	0	0.009096	0	0
SLFN13	146857	broad.mit.edu	37	17	33772525	33772525	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:33772525C>T	ENST00000285013.6	-	3	450	c.175G>A	c.(175-177)Gga>Aga	p.G59R	SLFN13_ENST00000542635.1_Missense_Mutation_p.G59R|SLFN13_ENST00000534689.1_Intron|SLFN13_ENST00000533791.1_Missense_Mutation_p.G59R|SLFN13_ENST00000526861.1_Missense_Mutation_p.G59R|SLFN13_ENST00000360502.2_Intron	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	59						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TGAATCACTCCTCCTCCTGAG	0.448000													5	83					0	0	0.021553	0	0
MUC16	94025	broad.mit.edu	37	19	9059040	9059040	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:9059040G>C	ENST00000397910.4	-	3	28609	c.28406C>G	c.(28405-28407)tCt>tGt	p.S9469C		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9471	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATCATGATAGAGGTGAAAAG	0.483000													47	144					0	0	0.139131	0	0
CNKSR2	22866	broad.mit.edu	37	X	21627328	21627328	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:21627328C>A	ENST00000425654.2	+	19	2675	c.2195C>A	c.(2194-2196)gCc>gAc	p.A732D	CNKSR2_ENST00000279451.4_Missense_Mutation_p.A762D|CNKSR2_ENST00000543067.1_Missense_Mutation_p.A713D|CNKSR2_ENST00000379510.3_Missense_Mutation_p.A762D	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	762					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						CGCAAGACAGCCAGTCAGCGC	0.527000													7	55					3.86212e-05	4.93589e-05	0.069234	1	0
CFH	3075	broad.mit.edu	37	1	196695702	196695702	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:196695702G>T	ENST00000367429.4	+	13	2216	c.1976G>T	c.(1975-1977)tGc>tTc	p.C659F		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	659	Sushi 11.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GAATATTATTGCAATCCTAGA	0.353000													7	75					2.0095e-06	2.70145e-06	0.029380	1	0
MT-CYB	4519	broad.mit.edu	37	MT	14902	14902	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrM:14902C>T	ENST00000361789.2	+	1	156	c.156C>T	c.(154-156)gcC>gcT	p.52_52insA						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						CTATTCCTAGCCATACACTAC	0.522000													6	719					0	0	0.021553	0	0
PPP1R9A	55607	broad.mit.edu	37	7	94540638	94540638	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:94540638A>T	ENST00000289495.5	+	1	1429	c.1213A>T	c.(1213-1215)Agg>Tgg	p.R405W	PPP1R9A_ENST00000433881.1_Missense_Mutation_p.R405W|PPP1R9A_ENST00000433360.1_Missense_Mutation_p.R405W|PPP1R9A_ENST00000456331.2_Missense_Mutation_p.R405W|PPP1R9A_ENST00000424654.1_Missense_Mutation_p.R405W|PPP1R9A_ENST00000340694.4_Missense_Mutation_p.R405W	NM_001166161.1	NP_001159633.1	Q9ULJ8	NEB1_HUMAN	protein phosphatase 1, regulatory subunit 9A	405						cell junction|synapse|synaptosome	actin binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(11)|liver(2)|lung(22)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(8)|urinary_tract(5)	71	all_cancers(62;9.12e-11)|all_epithelial(64;4.34e-09)		STAD - Stomach adenocarcinoma(171;0.0031)			TAATGTGTATAGGGTGAGATC	0.428000										HNSCC(28;0.073)			3	16					0	0	0.115264	0	0
SEC24C	9632	broad.mit.edu	37	10	75526300	75526300	+	Splice_Site	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:75526300G>T	ENST00000339365.2	+	13	1961		c.e13+1		SEC24C_ENST00000411652.2_Splice_Site|SEC24C_ENST00000345254.4_Splice_Site|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000546025.1_Splice_Site|SEC24C_ENST00000535742.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C						COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					TTATCACCAGGTAAGAGCCAG	0.512000													6	97					0.0215528	0.0228347	0.021553	1	0
HAUS8	93323	broad.mit.edu	37	19	17170423	17170423	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:17170423T>C	ENST00000593360.1	-	5	2199	c.181A>G	c.(181-183)Aca>Gca	p.T61A	HAUS8_ENST00000448593.2_Missense_Mutation_p.T121A|HAUS8_ENST00000253669.5_Missense_Mutation_p.T122A			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	122					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						TTTGATATTGTTTTTGCTAAC	0.438000													5	58					0	0	0.014758	0	0
NANOS2	339345	broad.mit.edu	37	19	46417902	46417902	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:46417902T>A	ENST00000341294.2	-	1	134	c.50A>T	c.(49-51)cAg>cTg	p.Q17L		NM_001029861.2	NP_001025032.1	P60321	NANO2_HUMAN	nanos homolog 2 (Drosophila)	17					germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	6		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		CCACACCACCTGGCTCAGGTT	0.652000													7	58					0	0	0.038147	0	0
ENPP6	133121	broad.mit.edu	37	4	185018489	185018489	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:185018489G>A	ENST00000296741.2	-	7	1167	c.1026C>T	c.(1024-1026)agC>agT	p.S342S		NM_153343.3	NP_699174.1	Q6UWR7	ENPP6_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 6	342					lipid catabolic process	extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	15		all_lung(41;7.99e-12)|Lung NSC(41;1.46e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;4.98e-27)|Epithelial(43;3.15e-24)|OV - Ovarian serous cystadenocarcinoma(60;4.09e-12)|Colorectal(24;3.78e-05)|STAD - Stomach adenocarcinoma(60;4.5e-05)|COAD - Colon adenocarcinoma(29;0.000154)|GBM - Glioblastoma multiforme(59;0.000167)|BRCA - Breast invasive adenocarcinoma(30;0.000378)|LUSC - Lung squamous cell carcinoma(40;0.0151)		GCCTGCCGGTGCTGTTCATCC	0.597000													9	60					0	0	0.105934	0	0
NAV1	89796	broad.mit.edu	37	1	201751666	201751666	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:201751666C>G	ENST00000367296.4	+	6	2446	c.2026C>G	c.(2026-2028)Cca>Gca	p.P676A	NAV1_ENST00000367300.3_Missense_Mutation_p.P676A|NAV1_ENST00000295624.6_Missense_Mutation_p.P676A|NAV1_ENST00000367302.1_Missense_Mutation_p.P689A|NAV1_ENST00000367297.4_Missense_Mutation_p.P676A|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367295.1_Missense_Mutation_p.P285A	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	676					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CCTGCCCCGGCCAGCCAAGTC	0.607000													35	88					0	0	0.139131	0	0
SSTR1	6751	broad.mit.edu	37	14	38679765	38679765	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:38679765C>T	ENST00000267377.2	+	3	1788	c.1171C>T	c.(1171-1173)Ctc>Ttc	p.L391F		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	391					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GATCACGACGCTCTGAGCCCG	0.652000													9	20					0	0	0.047766	0	0
SRM	6723	broad.mit.edu	37	1	11115026	11115026	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:11115026G>A	ENST00000376957.2	-	7	961	c.881C>T	c.(880-882)gCc>gTc	p.A294V		NM_003132.2	NP_003123.2	P19623	SPEE_HUMAN	spermidine synthase	294					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity			large_intestine(1)|lung(1)|urinary_tract(1)	3	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	CACCTTGCGGGCAAACTCGGG	0.667000													3	10					0	0	0.115264	0	0
LINC00854	100874261	broad.mit.edu	37	17	41381938	41381938	+	RNA	SNP	C	C	G	rs4986161		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:41381938C>G	ENST00000433702.2	-	0	14					NR_047479.1																						aagagctgatcttatgcaggg	0.552000													3	35					0	0	0.115264	0	0
ZC3H13	23091	broad.mit.edu	37	13	46543636	46543636	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:46543636C>T	ENST00000242848.4	-	14	3391	c.3043G>A	c.(3043-3045)Gat>Aat	p.D1015N	ZC3H13_ENST00000378921.2_5'UTR|ZC3H13_ENST00000282007.3_Missense_Mutation_p.D1015N			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1015	Lys-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCAGAAATATCAGAATCACCT	0.373000													12	71					0	0	0.080935	0	0
NPIPB5	100132247	broad.mit.edu	37	16	22545865	22545865	+	Missense_Mutation	SNP	G	G	C	rs147500263	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:22545865G>C	ENST00000424340.1	+	7	1840	c.1561G>C	c.(1561-1563)Gcc>Ccc	p.A521P	NPIPB5_ENST00000517539.1_Missense_Mutation_p.A521P|NPIPB5_ENST00000415654.1_3'UTR	NM_001135865.1	NP_001129337.1			nuclear pore complex interacting protein family, member B5																		TCAGCTCACTGCCCTTCCACC	0.567000													4	292					0	0	0.029380	0	0
MUC16	94025	broad.mit.edu	37	19	9065662	9065662	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:9065662C>T	ENST00000397910.4	-	3	21987	c.21784G>A	c.(21784-21786)Gag>Aag	p.E7262K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7264	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCACTTGTCTCTATGGCTGAG	0.483000													5	308					0	0	0.014758	0	0
CDHR1	92211	broad.mit.edu	37	10	85973089	85973089	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:85973089C>A	ENST00000372117.3	+	16	2128	c.2025C>A	c.(2023-2025)gaC>gaA	p.D675E	CDHR1_ENST00000440770.2_Missense_Mutation_p.D379E|CDHR1_ENST00000332904.3_Missense_Mutation_p.D675E	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	675	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						TCAAGATTGACATCACAGATG	0.562000													4	141					0.00024832	0.000303739	0.009096	1	0
MIR4485	100616263	broad.mit.edu	37	MT	2143	2143	+	RNA	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrM:2143G>A	ENST00000387347.2	+	0	473					NR_039705.1																						AAAAACCTTGTAGAGAGAGTA	0.383000													15	724					0	0	0.033300	0	0
MRPS2	51116	broad.mit.edu	37	9	138395821	138395821	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:138395821G>T	ENST00000371785.1	+	5	942	c.733G>T	c.(733-735)Gct>Tct	p.A245S	MRPS2_ENST00000241600.5_Missense_Mutation_p.A245S|RP11-426A6.5_ENST00000415062.1_RNA			Q9Y399	RT02_HUMAN	mitochondrial ribosomal protein S2	245					translation	mitochondrion|small ribosomal subunit	structural constituent of ribosome			large_intestine(2)|lung(1)|prostate(2)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(145;1.46e-53)|Epithelial(140;2.04e-47)|all cancers(34;1.23e-42)		CTCTCCGCTGGCTGTGCACCT	0.617000													5	33					2.17888e-05	2.83553e-05	0.058154	1	0
GLUD2	2747	broad.mit.edu	37	X	120182570	120182570	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:120182570C>A	ENST00000328078.1	+	1	1109	c.1032C>A	c.(1030-1032)gaC>gaA	p.D344E		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	344					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATGGTATTGACCCAAAGGAAC	0.453000													16	100					1.01871e-10	1.50432e-10	0.049695	1	0
CDC73	79577	broad.mit.edu	37	1	193117052	193117052	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:193117052G>T	ENST00000367435.3	+	8	969	c.785G>T	c.(784-786)gGg>gTg	p.G262V		NM_024529.4	NP_078805.3	Q6P1J9	CDC73_HUMAN	cell division cycle 73	262					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(14)|ovary(1)|pancreas(1)|parathyroid(51)|skin(1)|upper_aerodigestive_tract(1)	87						AGAGAAGAAGGGCGTGCACCT	0.363000													7	20					1.06961e-07	1.48702e-07	0.038147	1	0
SULT4A1	25830	broad.mit.edu	37	22	44234824	44234824	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:44234824T>A	ENST00000330884.4	-	4	551	c.431A>T	c.(430-432)cAg>cTg	p.Q144L	SULT4A1_ENST00000540422.1_Intron|SULT4A1_ENST00000249130.5_Missense_Mutation_p.Q144L	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	144					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GCGGTGGAACTGATAATAAGA	0.547000													4	21					0	0	0.009096	0	0
PAX5	5079	broad.mit.edu	37	9	36846921	36846921	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:36846921C>A	ENST00000358127.4	-	9	1092	c.1018G>T	c.(1018-1020)Gag>Tag	p.E340*	PAX5_ENST00000377847.2_Intron|PAX5_ENST00000377852.2_Nonsense_Mutation_p.E306*|PAX5_ENST00000520281.1_Intron|PAX5_ENST00000377853.2_Intron|PAX5_ENST00000522003.1_Nonsense_Mutation_p.E232*|PAX5_ENST00000446742.1_Nonsense_Mutation_p.E240*|PAX5_ENST00000523145.1_Intron|PAX5_ENST00000414447.1_Nonsense_Mutation_p.E297*|PAX5_ENST00000520154.1_Intron|PAX5_ENST00000523241.1_Silent_p.V262V	NM_016734.1	NP_057953.1	Q02548	PAX5_HUMAN	paired box 5	340					cell differentiation|humoral immune response|nervous system development|organ morphogenesis|spermatogenesis|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(11)	PAX5/JAK2(18)	NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(151)|kidney(1)|lung(10)|prostate(1)|skin(1)	171		all_cancers(2;3.46e-10)|Acute lymphoblastic leukemia(2;7.09e-56)|all_hematologic(2;6.65e-44)		GBM - Glioblastoma multiforme(29;0.0108)		CCGGAAAACTCACTCCCTGTG	0.577000			"""T, Mis, D, F, S"""	"""IGH@, ETV6, PML, FOXP1, ZNF521, ELN"""	"""NHL, ALL, B-ALL"""								3	21					0.115264	0.118593	0.115264	1	0
ZNF91	7644	broad.mit.edu	37	19	23542561	23542561	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:23542561T>C	ENST00000300619.7	-	4	3425	c.3220A>G	c.(3220-3222)Aga>Gga	p.R1074G	ZNF91_ENST00000397082.2_Missense_Mutation_p.R1042G|ZNF91_ENST00000599743.1_Intron	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1074						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTTCTCTCTAGTATGAATT	0.383000													3	93					0	0	0.115264	0	0
ATP2C2	9914	broad.mit.edu	37	16	84476176	84476176	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:84476176G>A	ENST00000416219.2	+	15	1461	c.1372G>A	c.(1372-1374)Gag>Aag	p.E458K	ATP2C2_ENST00000262429.4_Missense_Mutation_p.E458K|ATP2C2_ENST00000420010.2_3'UTR			O75185	AT2C2_HUMAN	ATPase, Ca++ transporting, type 2C, member 2	458					ATP biosynthetic process	Golgi membrane|integral to membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(3)|skin(5)|urinary_tract(1)	33						GCAGCCCACCGAGGGTGCATT	0.577000													6	176					0	0	0.021553	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			4	6					0.014758	0.0158121	0.014758	1	0
EGFL6	25975	broad.mit.edu	37	X	13645150	13645150	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:13645150G>T	ENST00000361306.1	+	11	1563	c.1306G>T	c.(1306-1308)Gtt>Ttt	p.V436F	EGFL6_ENST00000380602.3_Missense_Mutation_p.V437F|EGFL6_ENST00000473826.1_3'UTR	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	436	MAM.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						CTATATGGCAGTTCCGGCCTT	0.403000													7	47					3.86212e-05	4.93589e-05	0.069234	1	0
NCOA1	8648	broad.mit.edu	37	2	24930338	24930338	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:24930338G>T	ENST00000405141.1	+	14	2710	c.1999G>T	c.(1999-2001)Gcc>Tcc	p.A667S	NCOA1_ENST00000538539.1_Missense_Mutation_p.A667S|NCOA1_ENST00000348332.3_Missense_Mutation_p.A667S|NCOA1_ENST00000288599.5_Missense_Mutation_p.A667S|NCOA1_ENST00000407230.1_Missense_Mutation_p.A516S|NCOA1_ENST00000406961.1_Missense_Mutation_p.A667S|NCOA1_ENST00000395856.3_Missense_Mutation_p.A667S			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	667	Ser-rich.								PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTCCAACTCTGCCTCTGCTAA	0.493000			T	PAX3	alveolar rhadomyosarcoma								8	83					0.00621372	0.00691761	0.058154	1	0
IMPDH2	3615	broad.mit.edu	37	3	49065198	49065198	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:49065198G>A	ENST00000326739.4	-	5	515	c.476C>T	c.(475-477)tCc>tTc	p.S159F		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	159	CBS 1.				GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	GTCCCTGGAGGAGATGATGCC	0.562000													12	55					0	0	0.146539	0	0
UPRT	139596	broad.mit.edu	37	X	74513312	74513312	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:74513312C>A	ENST00000373379.1	+	2	557	c.392C>A	c.(391-393)gCc>gAc	p.A131D	UPRT_ENST00000530743.1_5'UTR|UPRT_ENST00000373383.4_Missense_Mutation_p.A131D|UPRT_ENST00000531704.1_3'UTR			Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)	131					nucleoside metabolic process	cytoplasm|nucleus				breast(1)|endometrium(7)|kidney(2)|large_intestine(4)|lung(4)	18						TTTAGGACAGCCAGTAGAGGT	0.343000													4	75					0.0215528	0.0228347	0.021553	1	0
SORL1	6653	broad.mit.edu	37	11	121448005	121448005	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:121448005G>T	ENST00000260197.7	+	25	3605	c.3476G>T	c.(3475-3477)cGg>cTg	p.R1159L	SORL1_ENST00000525532.1_Missense_Mutation_p.R103L|SORL1_ENST00000534286.1_Missense_Mutation_p.R69L|SORL1_ENST00000532694.1_Missense_Mutation_p.R5L	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1159	LDL-receptor class A 3.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CACCAGTGCCGGAGTGACGAG	0.512000													7	65					0.0293803	0.0307845	0.029380	1	0
TACR3	6870	broad.mit.edu	37	4	104640715	104640715	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:104640715C>A	ENST00000304883.2	-	1	258	c.118G>T	c.(118-120)Ggg>Tgg	p.G40W		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	40						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		TGCAGCCACCCAGTCTCAACT	0.692000													6	27					0.000274275	0.000332632	0.047766	1	0
MAP7	9053	broad.mit.edu	37	6	136687027	136687027	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:136687027C>G	ENST00000354570.3	-	10	1529	c.1119G>C	c.(1117-1119)aaG>aaC	p.K373N	MAP7_ENST00000544465.1_Missense_Mutation_p.K358N|MAP7_ENST00000438100.2_Missense_Mutation_p.K358N|MAP7_ENST00000454590.1_Missense_Mutation_p.K395N|MAP7_ENST00000432797.2_Missense_Mutation_p.K227N	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	373	Pro-rich.				establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		TGACTTCCCTCTTGACAGGGC	0.577000													7	27					0	0	0.038147	0	0
GRID2	2895	broad.mit.edu	37	4	94436475	94436475	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:94436475C>A	ENST00000282020.4	+	13	2364	c.2106C>A	c.(2104-2106)gaC>gaA	p.D702E	GRID2_ENST00000510992.1_Missense_Mutation_p.D607E	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	702					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TTGAGAGGGACAGCATGTATT	0.483000													4	37					0.014758	0.0158121	0.014758	1	0
MSANTD1	345222	broad.mit.edu	37	4	3254982	3254982	+	Silent	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:3254982C>G	ENST00000438480.2	+	2	2116	c.369C>G	c.(367-369)ccC>ccG	p.P123P	MSANTD1_ENST00000510580.1_Silent_p.P123P|MSANTD1_ENST00000507492.1_Silent_p.P110P	NM_001042690.1	NP_001036155.1	Q6ZTZ1	CD044_HUMAN	Myb/SANT-like DNA-binding domain containing 1	123										endometrium(1)|lung(2)	3						CCGACTGGCCCTATTACCTAG	0.602000													4	22					0	0	0.058154	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098968	178098968	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:178098968T>C	ENST00000397062.3	-	2	631	c.77A>G	c.(76-78)cAa>cGa	p.Q26R	NFE2L2_ENST00000464747.1_Missense_Mutation_p.Q10R|NFE2L2_ENST00000446151.2_Missense_Mutation_p.Q10R|NFE2L2_ENST00000423513.1_Missense_Mutation_p.Q10R|NFE2L2_ENST00000397063.4_Missense_Mutation_p.Q10R	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	26					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.Q26P(1)|p.Q26L(1)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ATCTATATCTTGCCTCCAAAG	0.348000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			5	28					0	0	0.021553	0	0
PPP2R5E	5529	broad.mit.edu	37	14	63920452	63920452	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:63920452G>A	ENST00000337537.3	-	3	911	c.309C>T	c.(307-309)agC>agT	p.S103S	PPP2R5E_ENST00000555899.1_Silent_p.S103S|PPP2R5E_ENST00000422769.2_Silent_p.S27S|PPP2R5E_ENST00000553266.1_Intron	NM_006246.2	NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	103					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		AACAGCCTCTGCTTATTGTAA	0.408000													14	100					0	0	0.033300	0	0
IGLV2-28	28812	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	7					0.004672	0.00528381	0.115264	1	0
SNX30	401548	broad.mit.edu	37	9	115598637	115598637	+	Silent	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:115598637C>G	ENST00000374232.3	+	5	926	c.762C>G	c.(760-762)ctC>ctG	p.L254L		NM_001012994.1	NP_001013012.1	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	254					cell communication|protein transport	cytoplasm	phosphatidylinositol binding			large_intestine(1)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						CATTTGCACTCAAACTGGGAA	0.507000													5	229					0	0	0.014758	0	0
LAMA3	3909	broad.mit.edu	37	18	21474312	21474312	+	Splice_Site	SNP	G	G	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:21474312G>C	ENST00000313654.9	+	43	5702	c.5461_splice	c.e43+1	p.D1821_splice	LAMA3_ENST00000587184.1_Splice_Site_p.D212_splice|LAMA3_ENST00000269217.6_Splice_Site_p.D212_splice|LAMA3_ENST00000399516.3_Splice_Site_p.D1821_splice	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1821	Domain III A.|Laminin EGF-like 15; truncated.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAATGTGATGGTGAGAAAAG	0.418000													17	117					0	0	0.055883	0	0
IGKV1D-42	28892	broad.mit.edu	37	2	90229097	90229097	+	RNA	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:90229097G>A	ENST00000390278.2	+	0	53																											AGCTCCTGGGGCTCCTGCTGC	0.537000													5	74					0	0	0.047766	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337402	22337402	+	RNA	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:22337402C>A	ENST00000390436.2	+	0	216																											AGGACCTCAGCTTATTATAGA	0.428000													6	268					8.12818e-05	0.000101602	0.029380	1	0
PDAP1	11333	broad.mit.edu	37	7	98995504	98995504	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:98995504C>G	ENST00000350498.3	-	5	748	c.468G>C	c.(466-468)aaG>aaC	p.K156N	PDAP1_ENST00000496335.1_5'UTR	NM_014891.6	NP_055706.1	Q13442	HAP28_HUMAN	PDGFA associated protein 1	156					cell proliferation|signal transduction					breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|ovary(2)|prostate(1)|skin(1)	9	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)		Becaplermin(DB00102)	CCTCTTCCTTCTTCCGGGCAG	0.612000													7	54					0	0	0.029380	0	0
SAGE1	55511	broad.mit.edu	37	X	134990727	134990727	+	Silent	SNP	T	T	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:134990727T>A	ENST00000535938.1	+	12	1559	c.1392T>A	c.(1390-1392)ctT>ctA	p.L464L	SAGE1_ENST00000324447.3_Silent_p.L464L|SAGE1_ENST00000370709.3_Silent_p.L464L|SAGE1_ENST00000537770.1_Intron	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	464										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					TATCCGGGCTTATTAATATGG	0.418000													11	63					0	0	0.038395	0	0
MLLT6	4302	broad.mit.edu	37	17	36873842	36873842	+	Silent	SNP	T	T	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:36873842T>G	ENST00000325718.7	+	11	1900	c.1809T>G	c.(1807-1809)tcT>tcG	p.S603S	CTB-58E17.9_ENST00000579499.1_RNA	NM_005937.3	NP_005928.2	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	603					regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8	Breast(7;4.43e-21)					TCCCCTCCTCTTCTGCTTCTA	0.667000			T	MLL	AL								4	39					0	0	0.014758	0	0
KCNC3	3748	broad.mit.edu	37	19	50826952	50826952	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:50826952G>A	ENST00000376959.2	-	2	1421	c.1258C>T	c.(1258-1260)Cgc>Tgc	p.R420C	KCNC3_ENST00000474951.1_Intron|KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.R420C			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	420			R -> H (in SCA13; loss of channel activity).		cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R420C(1)		endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		CGCAGGATGCGGACGAAGCGG	0.652000													3	19					0	0	0.115264	0	0
C9orf106	414318	broad.mit.edu	37	9	132084838	132084838	+	RNA	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:132084838C>T	ENST00000316786.1	+	0	799							Q8NAJ2	CI106_HUMAN	chromosome 9 open reading frame 106											large_intestine(1)|lung(1)|ovary(1)|skin(1)	4		Ovarian(14;0.00556)|Medulloblastoma(224;0.235)				AGGCACTGCCCAGAGCTCCTA	0.552000													6	17					0	0	0.038147	0	0
SEC24C	9632	broad.mit.edu	37	10	75526299	75526299	+	Splice_Site	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:75526299G>T	ENST00000339365.2	+	13	1961	c.1799_splice	c.e13+1	p.S600_splice	SEC24C_ENST00000411652.2_Splice_Site_p.S481_splice|SEC24C_ENST00000345254.4_Splice_Site_p.S600_splice|SEC24C_ENST00000540668.1_Intron|SEC24C_ENST00000546025.1_3'UTR|SEC24C_ENST00000535742.1_Intron	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	600					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					GTTATCACCAGGTAAGAGCCA	0.512000													6	97					0.0215528	0.0228347	0.021553	1	0
SLITRK1	114798	broad.mit.edu	37	13	84455171	84455171	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:84455171C>A	ENST00000377084.2	-	1	1357	c.472G>T	c.(472-474)Gtg>Ttg	p.V158L		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	158						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		AAAATGAGCACCTCCAGCTTG	0.498000													7	65					0.000157383	0.000194174	0.038147	1	0
ZNF678	339500	broad.mit.edu	37	1	227842544	227842544	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:227842544G>A	ENST00000343776.4	+	4	938	c.593G>A	c.(592-594)aGc>aAc	p.S198N	ZNF678_ENST00000498759.1_Intron|ZNF678_ENST00000397097.3_Missense_Mutation_p.S253N			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	253					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				CAACTAACTAGCCATAAGAAA	0.363000													5	228					0	0	0.021553	0	0
OR4M2	390538	broad.mit.edu	37	15	22369034	22369034	+	Silent	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:22369034C>T	ENST00000332663.2	+	1	557	c.459C>T	c.(457-459)ttC>ttT	p.F153F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGGGGGGCTTCATTCATTCTA	0.502000													6	201					0	0	0.029380	0	0
PRKCB	5579	broad.mit.edu	37	16	24135199	24135199	+	Missense_Mutation	SNP	C	C	T	rs139055681	byFrequency	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:24135199C>T	ENST00000303531.7	+	9	1114	c.962C>T	c.(961-963)aCg>aTg	p.T321M	PRKCB_ENST00000321728.7_Missense_Mutation_p.T321M	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	321					apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GAAGAAAAGACGACCAACACT	0.483000													24	158					0	0	0.116897	0	0
OR2M2	391194	broad.mit.edu	37	1	248343745	248343745	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:248343745C>G	ENST00000359682.2	+	1	458	c.458C>G	c.(457-459)tCt>tGt	p.S153C		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATCCTGGGCTCTACAGATGGA	0.433000													6	100					0	0	0.021553	0	0
GAB3	139716	broad.mit.edu	37	X	153925479	153925479	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:153925479G>A	ENST00000369575.3	-	7	1383	c.1352C>T	c.(1351-1353)cCt>cTt	p.P451L	GAB3_ENST00000424127.2_Missense_Mutation_p.P452L|GAB3_ENST00000496390.1_5'UTR	NM_001081573.1|NM_080612.2	NP_001075042.1|NP_542179.1	Q8WWW8	GAB3_HUMAN	GRB2-associated binding protein 3	451										NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)	25	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTCCAGAGGAGGTGGCCGTGC	0.502000													6	81					0	0	0.021553	0	0
HK2	3099	broad.mit.edu	37	2	75094768	75094768	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:75094768G>T	ENST00000290573.2	+	3	832	c.232G>T	c.(232-234)Gga>Tga	p.G78*	HK2_ENST00000409174.1_Nonsense_Mutation_p.G50*	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	78	Regulatory.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity	p.G78*(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						TGCAGAACACGGAGAGTTCCT	0.483000													12	438					1.08611e-07	1.50262e-07	0.080935	1	0
APBB3	10307	broad.mit.edu	37	5	139941222	139941222	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:139941222C>T	ENST00000357560.4	-	8	1140	c.697G>A	c.(697-699)Gat>Aat	p.D233N	APBB3_ENST00000356738.2_Missense_Mutation_p.D238N|APBB3_ENST00000511201.2_Missense_Mutation_p.D231N|APBB3_ENST00000358580.5_Missense_Mutation_p.D233N|APBB3_ENST00000508496.2_Missense_Mutation_p.D10N|APBB3_ENST00000354402.5_Missense_Mutation_p.D240N|APBB3_ENST00000412920.3_Missense_Mutation_p.D231N	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	233	PID 1.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCAGGGACATCACAGCAAAAC	0.557000													17	147					0	0	0.033300	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77389870	77389870	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:77389870G>T	ENST00000282849.5	-	9	1845	c.1427C>A	c.(1426-1428)tCc>tAc	p.S476Y		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	476	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GCGGCTGCAGGAAGACCATGA	0.483000													4	61					0.00909568	0.00989416	0.009096	1	0
MECOM	2122	broad.mit.edu	37	3	168833844	168833844	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:168833844C>T	ENST00000464456.1	-	7	2452	c.1252G>A	c.(1252-1254)Gaa>Aaa	p.E418K	MECOM_ENST00000468789.1_Missense_Mutation_p.E418K|MECOM_ENST00000494292.1_Missense_Mutation_p.E606K|MECOM_ENST00000433243.2_Missense_Mutation_p.E419K|MECOM_ENST00000460814.1_Missense_Mutation_p.E418K|MECOM_ENST00000392736.3_Missense_Mutation_p.E418K|MECOM_ENST00000472280.1_Missense_Mutation_p.E419K|MECOM_ENST00000264674.3_Missense_Mutation_p.E483K	NM_001164000.1	NP_001157472.1	Q13465	MDS1_HUMAN	MDS1 and EVI1 complex locus	0							sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	85						TTATCACTTTCAATGTCACTT	0.383000													4	61					0	0	0.009096	0	0
SPATA18	132671	broad.mit.edu	37	4	52944971	52944971	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:52944971C>G	ENST00000295213.4	+	8	1465	c.1091C>G	c.(1090-1092)tCt>tGt	p.S364C	SPATA18_ENST00000419395.2_Missense_Mutation_p.S332C	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	364					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TTGACACCATCTTATGTGGGG	0.378000													4	121					0	0	0.014758	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370101	35370101	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:35370101G>A	ENST00000373347.1	-	3	1152	c.884C>T	c.(883-885)tCc>tTc	p.S295F	DLGAP3_ENST00000235180.4_Missense_Mutation_p.S295F			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	295					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GTCCCGGTAGGACCCATCTGG	0.642000													7	128					0	0	0.029380	0	0
SPATA18	132671	broad.mit.edu	37	4	52938291	52938291	+	Silent	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:52938291C>T	ENST00000295213.4	+	6	1101	c.727C>T	c.(727-729)Ctg>Ttg	p.L243L	SPATA18_ENST00000506829.1_3'UTR|SPATA18_ENST00000419395.2_Silent_p.L211L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	243					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GATAGCTGTTCTGTCTGCTGA	0.478000													15	146					0	0	0.132662	0	0
CCDC50	152137	broad.mit.edu	37	3	191107310	191107310	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:191107310G>A	ENST00000392455.3	+	10	1418	c.820G>A	c.(820-822)Ggt>Agt	p.G274S	CCDC50_ENST00000392456.3_Missense_Mutation_p.G450S	NM_174908.3	NP_777568.1	Q8IVM0	CCD50_HUMAN	coiled-coil domain containing 50	274						cytoplasm	protein binding			endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|stomach(1)	23	all_cancers(143;8.88e-09)|Ovarian(172;0.103)|Breast(254;0.221)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000136)		CATGACAGATGGTGAAGATGC	0.428000													47	252					0	0	0.139131	0	0
SYN1	6853	broad.mit.edu	37	X	47466579	47466579	+	Silent	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:47466579C>T	ENST00000295987.7	-	2	520	c.396G>A	c.(394-396)ggG>ggA	p.G132G	SYN1_ENST00000340666.4_Silent_p.G132G	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	132	C; actin-binding and synaptic-vesicle binding.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						GGATCTTTTTCCCTTTGAAGT	0.438000													4	50					0	0	0.014758	0	0
TRPC5	7224	broad.mit.edu	37	X	111095552	111095552	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:111095552A>T	ENST00000262839.2	-	5	2269	c.1351T>A	c.(1351-1353)Tcc>Acc	p.S451T		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	451					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						ATCTTCAGGGAAATAGTTGCC	0.413000													5	64					0	0	0.014758	0	0
LPAR3	23566	broad.mit.edu	37	1	85331432	85331432	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:85331432G>A	ENST00000440886.1	-	1	410	c.372C>T	c.(370-372)gcC>gcT	p.A124A	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Silent_p.A124A			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	124					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						GCCTCTCCACGGCGATAACCA	0.517000													28	305					0	0	0.054565	0	0
C11orf87	399947	broad.mit.edu	37	11	109294724	109294724	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:109294724C>T	ENST00000327419.6	+	2	768	c.365C>T	c.(364-366)gCc>gTc	p.A122V	RP11-708B6.2_ENST00000532992.1_RNA|RP11-708B6.2_ENST00000532929.1_RNA	NM_207645.3	NP_997528.2	Q6NUJ2	CK087_HUMAN	chromosome 11 open reading frame 87	122						integral to membrane				breast(2)|endometrium(1)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17						GGCAGGCAGGCCCCAACCCAC	0.672000													6	35					0	0	0.038147	0	0
KCNMA1	3778	broad.mit.edu	37	10	78669850	78669850	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:78669850G>A	ENST00000286627.5	-	24	3799	c.2847C>T	c.(2845-2847)aaC>aaT	p.N949N	KCNMA1_ENST00000406533.3_Silent_p.N1011N|KCNMA1_ENST00000404857.1_Silent_p.N990N|KCNMA1_ENST00000404771.3_Silent_p.N1007N|KCNMA1_ENST00000354353.5_Silent_p.N1010N|RP11-443A13.5_ENST00000426234.1_RNA|KCNMA1_ENST00000286628.8_Silent_p.N1007N|KCNMA1_ENST00000372440.1_Silent_p.N949N|RP11-443A13.5_ENST00000458661.2_RNA|RP11-443A13.5_ENST00000600782.1_RNA|KCNMA1_ENST00000372443.1_Silent_p.N976N	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	1007					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CATTAGTATCGTTCACTAGAA	0.448000													8	27					0	0	0.069234	0	0
TCF20	6942	broad.mit.edu	37	22	42605702	42605702	+	Silent	SNP	G	G	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:42605702G>A	ENST00000359486.3	-	1	5746	c.5610C>T	c.(5608-5610)ggC>ggT	p.G1870G	TCF20_ENST00000404876.1_Silent_p.G171G|TCF20_ENST00000335626.4_Silent_p.G1870G	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1870					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						CATAGAGCCTGCCACAAACCA	0.453000													5	353					0	0	0.014758	0	0
OR4D9	390199	broad.mit.edu	37	11	59282609	59282609	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:59282609C>A	ENST00000329328.3	+	1	224	c.224C>A	c.(223-225)tCc>tAc	p.S75Y		NM_001004711.1	NP_001004711.1	Q8NGE8	OR4D9_HUMAN	olfactory receptor, family 4, subfamily D, member 9	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|prostate(5)|upper_aerodigestive_tract(1)	26						TGCTTTTCCTCCATCACAGCT	0.458000													22	123					1.10513e-12	1.66647e-12	0.069288	1	0
USP6NL	9712	broad.mit.edu	37	10	11504651	11504651	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:11504651C>G	ENST00000379237.1	-	15	2670	c.2276G>C	c.(2275-2277)gGc>gCc	p.G759A	USP6NL_ENST00000277575.5_Missense_Mutation_p.G776A	NM_014688.2	NP_055503.1	Q92738	US6NL_HUMAN	USP6 N-terminal like	759						intracellular	Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(18)|prostate(1)|skin(1)|urinary_tract(1)	32						TGGTAAATTGCCACGGCTAGC	0.478000													4	96					0	0	0.009096	0	0
OR2AK2	391191	broad.mit.edu	37	1	248129009	248129009	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:248129009G>T	ENST00000366480.3	+	1	475	c.376G>T	c.(376-378)Gaa>Taa	p.E126*	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGGTGGAACTGAAGCCCTTCT	0.443000													34	272					1.04594e-18	1.61131e-18	0.086207	1	0
NLRC4	58484	broad.mit.edu	37	2	32476460	32476460	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:32476460A>T	ENST00000404025.2	-	5	961	c.473T>A	c.(472-474)cTg>cAg	p.L158Q	NLRC4_ENST00000402280.1_Missense_Mutation_p.L158Q|NLRC4_ENST00000360906.5_Missense_Mutation_p.L158Q|NLRC4_ENST00000342905.6_Intron			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	158					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AAGAGCCTGCAGGAGGCCATT	0.542000													5	38					0	0	0.014758	0	0
RBM5	10181	broad.mit.edu	37	3	50148145	50148145	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:50148145A>T	ENST00000347869.3	+	17	1572	c.1397A>T	c.(1396-1398)gAa>gTa	p.E466V	RBM5_ENST00000441812.2_3'UTR	NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	466	Required for interaction with U2AF2.|Sufficient for interaction with ACIN1, PRPF8, SFRS3, SNRPB, SNRPN, SNRNP70 and SNRNP200.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CAGTATGATGAATCTTCAGGA	0.398000													6	23					0	0	0.029380	0	0
ZXDA	7789	broad.mit.edu	37	X	57934639	57934639	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:57934639A>T	ENST00000358697.4	-	1	2428	c.2216T>A	c.(2215-2217)cTt>cAt	p.L739H		NM_007156.4	NP_009087.1	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	739					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|prostate(2)|skin(1)	37						GTTTTCACAAAGGGTGCTCGA	0.498000													4	31					0	0	0.021553	0	0
LINC01141	339505	broad.mit.edu	37	1	20748574	20748574	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:20748574delA	ENST00000426428.1	-	0	199					NR_033887.1																						tgggtgtggcaagctgacaaa	0.507													2	4	---	---	---	---					
LINC01359	101927084	broad.mit.edu	37	1	65447767	65447768	+	RNA	DEL	AC	AC	-	rs35511487		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:65447767_65447768delAC	ENST00000447748.1	-	0	1775																											AAGTTAAATAacacacacacac	0.431													2	4	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68351258	68351259	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:68351258_68351259insA	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000413628.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			TAGAGAGAGAGAAAAAAAGTCA	0.431													2	4	---	---	---	---					
CLCA2	9635	broad.mit.edu	37	1	86921042	86921043	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:86921042_86921043insC	ENST00000370565.4	+	14	2826_2827	c.2664_2665insC	c.(2662-2667)atccccfs	p.IP888fs		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	888					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CTCTGTTTATTCCCCCCAATTC	0.396													7	210	---	---	---	---					
LOC100129620	100129620	broad.mit.edu	37	1	99561542	99561542	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:99561542delT	ENST00000425113.1	+	0	370					NR_033940.1																						ggttgatggcttttttttttc	0.323													2	4	---	---	---	---					
AP4B1	10717	broad.mit.edu	37	1	114442681	114442682	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:114442681_114442682insA	ENST00000369569.1	-	5	1238_1239	c.958_959insT	c.(958-960)ctcfs	p.L320fs	AP4B1_ENST00000369566.3_Frame_Shift_Ins_p.L227fs|AP4B1_ENST00000369567.1_Frame_Shift_Ins_p.L152fs|AP4B1_ENST00000256658.4_Frame_Shift_Ins_p.L320fs|AP4B1-AS1_ENST00000419536.1_RNA	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	320					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CGAGTAGGAGCAAAAAAACTTT	0.470													7	425	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142620158	142620159	+	RNA	INS	-	-	G	rs111305414		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:142620158_142620159insG	ENST00000426408.1	+	0	457																											cctggatcacaaaaagtcctta	0.431													2	4	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143169462	143169463	+	RNA	INS	-	-	C	rs140782144		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:143169462_143169463insC	ENST00000412204.2	-	0	2503				RP11-782C8.1_ENST00000438000.1_lincRNA|RP11-782C8.4_ENST00000424474.2_lincRNA																							CCTGctgaccaccccccactaa	0.515													3	2	---	---	---	---					
RP11-640M9.2	0	broad.mit.edu	37	1	144597567	144597568	+	RNA	INS	-	-	A	rs67984124		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:144597567_144597568insA	ENST00000419820.1	+	0	439																											TAAAATCTCTTACAGCTATTAT	0.272													5	3	---	---	---	---					
BCL9	607	broad.mit.edu	37	1	147092680	147092681	+	Frame_Shift_Ins	INS	-	-	C	rs35292683		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:147092680_147092681insC	ENST00000234739.3	+	8	3459_3460	c.2719_2720insC	c.(2719-2721)cccfs	p.P907fs		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	907	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					TTCCATTAAGTCCCCCCCTGTT	0.619			T	"""IGH@, IGL@"""	B-ALL								9	223	---	---	---	---					
FLG-AS1	339400	broad.mit.edu	37	1	152150137	152150138	+	RNA	INS	-	-	TT			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:152150137_152150138insTT	ENST00000593011.1	+	0	296																											gtgatgttgagttttttttcat	0.337													2	4	---	---	---	---					
RP11-307C12.13	0	broad.mit.edu	37	1	154910321	154910322	+	RNA	DEL	TT	TT	-	rs12045997	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:154910321_154910322delTT	ENST00000604546.1	+	0	476_477																											TTTTTTGGGGTTTTTTTTGTTT	0.421													2	4	---	---	---	---					
SHC1	6464	broad.mit.edu	37	1	154938467	154938468	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:154938467_154938468insG	ENST00000448116.2	-	10	1561_1562	c.1341_1342insC	c.(1339-1344)ccatccfs	p.S448fs	SHC1_ENST00000606391.1_Frame_Shift_Ins_p.S248fs|SHC1_ENST00000368450.1_Frame_Shift_Ins_p.S337fs|SHC1_ENST00000368449.4_Frame_Shift_Ins_p.S218fs|SHC1_ENST00000368453.4_Frame_Shift_Ins_p.S338fs|SHC1_ENST00000368445.5_Frame_Shift_Ins_p.S447fs	NM_001130040.1	NP_001123512.1	P29353	SHC1_HUMAN	SHC (Src homology 2 domain containing) transforming protein 1	447	CH1.|Pro-rich.				activation of MAPK activity|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|positive regulation of DNA replication|Ras protein signal transduction|regulation of epidermal growth factor receptor activity|regulation of growth	cytosol|mitochondrial matrix|Shc-EGFR complex	epidermal growth factor receptor binding|insulin receptor binding|insulin-like growth factor receptor binding|phospholipid binding|protein binding|transmembrane receptor protein tyrosine kinase adaptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	20	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			ATAGCAGGATTGGGGGGCCCAG	0.569													11	274	---	---	---	---					
RP11-180D21.3	0	broad.mit.edu	37	1	159446352	159446352	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:159446352delT	ENST00000412932.1	+	0	380																											ggctcctttcttcctggaagg	0.433													2	4	---	---	---	---					
RP3-454G6.2	0	broad.mit.edu	37	1	171595185	171595186	+	RNA	INS	-	-	T	rs78900605	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:171595185_171595186insT	ENST00000483518.1	+	0	228																											GTTAACTATTCTTTTTAGATGC	0.431													5	1	---	---	---	---					
RP1-35C21.2	0	broad.mit.edu	37	1	177458291	177458291	+	RNA	DEL	G	G	-	rs66978685		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:177458291delG	ENST00000438575.1	-	0	296																											acacaaaattgtcatttttgt	0.308													2	4	---	---	---	---					
GM140	100287948	broad.mit.edu	37	1	181207582	181207583	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:181207582_181207583insG	ENST00000319701.2	+	0	224					NR_046249.1																						CTTTCCAATTTGGGGGATTTTT	0.416													2	4	---	---	---	---					
LINC01344	400799	broad.mit.edu	37	1	182264632	182264633	+	RNA	INS	-	-	AGAGAG	rs71124819	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:182264632_182264633insAGAGAG	ENST00000449842.1	-	0	410																											gaaaaaagaaaagagagaagaa	0.381													4	5	---	---	---	---					
GOLT1A	127845	broad.mit.edu	37	1	204170835	204170836	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:204170835_204170836insC	ENST00000308302.3	-	3	406_407	c.221_222insG	c.(220-222)ggtfs	p.G74fs		NM_198447.1	NP_940849.1	Q6ZVE7	GOT1A_HUMAN	golgi transport 1A	74					protein transport|vesicle-mediated transport	Golgi membrane|integral to membrane				kidney(1)|lung(2)|urinary_tract(1)	4	all_cancers(21;0.0165)|Breast(84;0.179)|all_epithelial(62;0.242)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.244)			CGATAACCACACCCCCCAGGAG	0.545													14	433	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222403294	222403295	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:222403294_222403295insT	ENST00000416510.1	-	0	167																											ctatcatattcttttttgtatt	0.342													2	4	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222444168	222444169	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:222444168_222444169insT	ENST00000416510.1	-	0	167																											cattaatcctctttttttgtaa	0.446													2	4	---	---	---	---					
RP11-278H7.4	0	broad.mit.edu	37	1	244245399	244245400	+	RNA	INS	-	-	G	rs145212889	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr1:244245399_244245400insG	ENST00000441338.1	-	0	74																											AAAGTCCTCGTCCTTCTTTCAA	0.559													3	6	---	---	---	---					
AC011995.1	0	broad.mit.edu	37	2	2841417	2841420	+	RNA	DEL	CACT	CACT	-	rs72345402		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:2841417_2841420delCACT	ENST00000452701.1	-	0	243																											CAGACTCACACACTCACTCAGTGA	0.569													2	4	---	---	---	---					
AC010145.4	0	broad.mit.edu	37	2	16179757	16179760	+	RNA	DEL	TTCT	TTCT	-	rs146901145	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:16179757_16179760delTTCT	ENST00000422415.2	-	0	152																											ccttccttccttctttccttcctt	0.353													5	10	---	---	---	---					
AC010880.1	0	broad.mit.edu	37	2	16574606	16574606	+	RNA	DEL	A	A	-	rs34153866		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:16574606delA	ENST00000427950.1	+	0	157																											AACTCAGCACAAAAAAAGGTT	0.418													6	5	---	---	---	---					
AC016995.3	0	broad.mit.edu	37	2	38730592	38730593	+	RNA	INS	-	-	AGA	rs147557314	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:38730592_38730593insAGA	ENST00000417039.1	-	0	294																											acaaaagagagagaaggagaaa	0.421													6	3	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52067349	52067349	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:52067349delA	ENST00000440698.1	+	0	839																											tggtcgctataaaaaaaattt	0.408													4	2	---	---	---	---					
RP11-481J13.1	0	broad.mit.edu	37	2	56318960	56318961	+	RNA	DEL	GA	GA	-	rs72402939		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:56318960_56318961delGA	ENST00000606639.1	+	0	159																											tttgttttttgatttttttttt	0.332													2	4	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60110483	60110484	+	RNA	INS	-	-	GGAGAGCAGGTTCC	rs148647260	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:60110483_60110484insGGAGAGCAGGTTCC	ENST00000606382.1	-	0	110																											CATATTGGAATGGAGAGCAGGT	0.460													4	6	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60177196	60177196	+	RNA	DEL	A	A	-	rs75775662		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:60177196delA	ENST00000606382.1	-	0	110																											tttctcaaagaaaaaaaaaaa	0.443													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65859718	65859718	+	RNA	DEL	T	T	-	rs35706578		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:65859718delT	ENST00000420724.1	-	0	63				AC074391.1_ENST00000377977.3_lincRNA																							aatttctttcttttttttttg	0.393													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65898676	65898676	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:65898676delA	ENST00000377977.3	+	0	862																											agcctgagacaaaagccaaca	0.478													2	4	---	---	---	---					
AC007040.8	0	broad.mit.edu	37	2	71280399	71280400	+	RNA	INS	-	-	TAT	rs142584374	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:71280399_71280400insTAT	ENST00000434990.1	-	0	61																											actttctgagatatgaatagca	0.386													2	4	---	---	---	---					
AC084193.1	0	broad.mit.edu	37	2	80958022	80958023	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:80958022_80958023insA	ENST00000450290.1	-	0	468																											gctaaagaactaaaaaatcagg	0.282													2	4	---	---	---	---					
LINC00152	112597	broad.mit.edu	37	2	112025548	112025549	+	RNA	DEL	AA	AA	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:112025548_112025549delAA	ENST00000438897.1	+	0	181																											ggtttgttagaaagatatttta	0.470													3	4	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145605040	145605041	+	RNA	INS	-	-	CA	rs10628901		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:145605040_145605041insCA	ENST00000445791.1	+	0	307					NR_033870.2																						TAGGACTTCTTcacacacacac	0.450													3	6	---	---	---	---					
AC016682.1	0	broad.mit.edu	37	2	151122538	151122538	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:151122538delT	ENST00000437118.1	+	0	260																											ttagattaccttcacattttt	0.259													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165150927	165150927	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:165150927delA	ENST00000429636.1	-	0	104																											aaggtcaattaaaaaaaaaag	0.303													2	4	---	---	---	---					
AC009495.2	0	broad.mit.edu	37	2	166657912	166657912	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:166657912delG	ENST00000425688.1	+	0	451				AC009495.4_ENST00000428888.1_lincRNA																							gaagaagtctggggcgaaagg	0.507													2	4	---	---	---	---					
AC096649.3	0	broad.mit.edu	37	2	176198622	176198622	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:176198622delG	ENST00000438963.1	+	0	247																											gaggagaagaggggagaagag	0.438													2	4	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182005544	182005545	+	RNA	INS	-	-	T	rs34914252		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:182005544_182005545insT	ENST00000435411.1	+	0	144																											tttgttttttgttttttttttg	0.317													2	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208194431	208194432	+	RNA	INS	-	-	A	rs149596319	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:208194431_208194432insA	ENST00000418850.1	-	0	455				AC007879.5_ENST00000412387.1_RNA																							gtatggctgtcagtgtttctgg	0.480													4	6	---	---	---	---					
AC098820.2	0	broad.mit.edu	37	2	217263176	217263177	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:217263176_217263177insT	ENST00000457694.1	-	0	272																											TCGAAGTAAGGTTTTTTTAAAC	0.297													3	3	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217760940	217760941	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:217760940_217760941insT	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							TGTGAATGCGGTTTTTTTTCCT	0.431													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217815776	217815777	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:217815776_217815777insT	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							TAGCATTGCTATttttttttaa	0.322													2	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217839932	217839933	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:217839932_217839933insG	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							attagttttctggggctgccat	0.475													2	4	---	---	---	---					
LINC01237	101927289	broad.mit.edu	37	2	242964825	242964826	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr2:242964825_242964826insG	ENST00000415434.1	+	0	310																											ctggagaccctggggggagctg	0.604													2	4	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	647194	647195	+	RNA	INS	-	-	T	rs79214683	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:647194_647195insT	ENST00000420823.1	+	0	176																											gttgcctcatgtttttgatgct	0.371													2	4	---	---	---	---					
AC027119.1	0	broad.mit.edu	37	3	6146922	6146925	+	RNA	DEL	TCTT	TCTT	-	rs71625311		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:6146922_6146925delTCTT	ENST00000425894.1	+	0	322																											tttttctttctctttctttctttc	0.382													3	3	---	---	---	---					
LINC00620	285375	broad.mit.edu	37	3	13729726	13729727	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:13729726_13729727insG	ENST00000419618.1	+	0	217				LINC00620_ENST00000438915.1_RNA	NR_027103.1																						GTGAGCTGAGCGGGGGGAGAAG	0.559													2	4	---	---	---	---					
SATB1-AS1	101927777	broad.mit.edu	37	3	18586112	18586113	+	RNA	DEL	TT	TT	-	rs143067600		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:18586112_18586113delTT	ENST00000595865.1	+	0	364				AC144521.1_ENST00000596139.1_RNA|AC144521.1_ENST00000596152.1_RNA|AC144521.1_ENST00000600177.1_RNA|AC144521.1_ENST00000595388.1_RNA|AC144521.1_ENST00000599762.1_RNA|AC144521.1_ENST00000596307.1_RNA|AC144521.1_ENST00000598390.1_RNA|AC144521.1_ENST00000595250.1_RNA|AC144521.1_ENST00000456253.2_RNA																							TGCGTTGCaatttttttttttt	0.436													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64763854	64763855	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:64763854_64763855insA	ENST00000460833.1	+	0	430				ADAMTS9-AS2_ENST00000481312.1_RNA|ADAMTS9-AS2_ENST00000474768.1_RNA																							caatcaagtggaaaaaaggata	0.361													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64831143	64831144	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:64831143_64831144insC	ENST00000474768.1	+	0	573				ADAMTS9-AS2_ENST00000481312.1_RNA																							tctggaagcttccccagccatc	0.525													2	4	---	---	---	---					
RP11-543A18.1	0	broad.mit.edu	37	3	65168852	65168852	+	RNA	DEL	C	C	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:65168852delC	ENST00000481004.1	+	0	119																											tggggtttcaccatgttgccc	0.547													2	4	---	---	---	---					
RP11-354H21.1	0	broad.mit.edu	37	3	78090811	78090812	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:78090811_78090812insA	ENST00000465795.1	-	0	203																											TTAGCCACACCAAAAATGTTTG	0.406													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82482833	82482833	+	RNA	DEL	A	A	-	rs35183441		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:82482833delA	ENST00000470263.1	+	0	654																											aaagaaaaagaaaaaaaaaga	0.403													3	4	---	---	---	---					
LINC00636	285205	broad.mit.edu	37	3	107638043	107638044	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:107638043_107638044insT	ENST00000494231.1	+	0	59					NR_015394.1																						GGGATCCCTCAGGGATGACAAA	0.446													2	4	---	---	---	---					
RP11-384F7.1	0	broad.mit.edu	37	3	118199520	118199520	+	RNA	DEL	C	C	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:118199520delC	ENST00000482142.1	-	0	232																											AGGTGTTGAGCCCCATGAAAT	0.423													2	4	---	---	---	---					
MYLK-AS1	100506826	broad.mit.edu	37	3	123315773	123315775	+	RNA	DEL	TCT	TCT	-	rs4048419		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:123315773_123315775delTCT	ENST00000470449.1	+	0	246				MYLK-AS1_ENST00000485162.1_RNA|MYLK-AS1_ENST00000463408.1_RNA	NR_038266.1																						gagatagatgtcttcttcttttt	0.345													3	4	---	---	---	---					
LOC100507291	100507291	broad.mit.edu	37	3	139119762	139119763	+	RNA	INS	-	-	AA	rs147505200		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:139119762_139119763insAA	ENST00000504670.1	+	0	433				RP11-319G6.1_ENST00000507362.1_RNA|RP11-319G6.1_ENST00000512622.1_RNA|RP11-319G6.1_ENST00000510068.1_RNA|RP11-319G6.1_ENST00000514729.1_RNA|RP11-319G6.1_ENST00000515247.1_RNA																							ggctccatctcaaaaaaaaaaa	0.446													4	3	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	147070372	147070372	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:147070372delA	ENST00000473299.1	-	0	132																											ATATCTGAGCAAAAAAAAAAA	0.259													3	3	---	---	---	---					
AADACL2-AS1	101928142	broad.mit.edu	37	3	151485667	151485668	+	RNA	INS	-	-	T	rs113696738	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:151485667_151485668insT	ENST00000483843.2	-	0	499				RP11-454C18.2_ENST00000475855.1_RNA																							ctactgatccattttttctgta	0.361													4	3	---	---	---	---					
RP11-292E2.1	0	broad.mit.edu	37	3	153077155	153077155	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:153077155delA	ENST00000498457.1	+	0	133																											ccttaagggcaaaaactgtgt	0.378													3	3	---	---	---	---					
RP11-290K4.2	0	broad.mit.edu	37	3	157747769	157747769	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:157747769delT	ENST00000488999.1	-	0	488																											CACAAACAAGTTTATActtcc	0.478													2	4	---	---	---	---					
LOC100128164	100128164	broad.mit.edu	37	3	169665167	169665168	+	RNA	INS	-	-	T	rs148209516	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr3:169665167_169665168insT	ENST00000483289.2	-	0	2126_2127				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						GTTTCCACACATTTTTTTCCCC	0.386													3	4	---	---	---	---					
LINC00955	285492	broad.mit.edu	37	4	3590824	3590825	+	Frame_Shift_Del	DEL	AC	AC	-	rs72442405		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:3590824_3590825delAC	ENST00000514422.1	+	3	595_596	c.309_310delAC	c.(307-312)agacfs	p.RH103fs																								acatgcacagacacacacacac	0.441													4	4	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15300547	15300547	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:15300547delA	ENST00000502344.1	-	0	86																											TGGCTAAGGCAATGGTTAAGC	0.383													2	4	---	---	---	---					
LINC01088	100505875	broad.mit.edu	37	4	79987924	79987925	+	RNA	DEL	TA	TA	-	rs5001816	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:79987924_79987925delTA	ENST00000509088.1	+	0	182				RP11-438E5.1_ENST00000510667.1_RNA	NR_038342.1																						GAGTGTAGGTTAAAAAAAAAAG	0.366													2	4	---	---	---	---					
RP11-742B18.1	0	broad.mit.edu	37	4	88513677	88513678	+	RNA	INS	-	-	TCAC	rs141556372	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:88513677_88513678insTCAC	ENST00000506480.1	-	0	322																											catgctcaacatcactaatcat	0.347													2	4	---	---	---	---					
LOC100507053	100507053	broad.mit.edu	37	4	100178468	100178468	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:100178468delG	ENST00000500358.2	+	0	3789				RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000509295.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA	NR_037884.1																						aagaataccagggaagccagt	0.378													2	4	---	---	---	---					
LOC256880	256880	broad.mit.edu	37	4	100912761	100912761	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:100912761delT	ENST00000507494.1	+	0	191				RP11-15B17.1_ENST00000501976.2_RNA																							TCATTATGCCTTTTTTATTTC	0.353													2	4	---	---	---	---					
LOC101929595	101929595	broad.mit.edu	37	4	108845248	108845249	+	RNA	DEL	GT	GT	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:108845248_108845249delGT	ENST00000499098.1	-	0	149				RP11-286E11.1_ENST00000513071.1_RNA																							AGGCAAAAGGgtgtgtgtgtgt	0.391													2	4	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128234080	128234081	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:128234080_128234081insA	ENST00000504050.1	-	0	368																											attatgagcccaaaaaaaagcc	0.391													2	4	---	---	---	---					
RP13-578N3.3	0	broad.mit.edu	37	4	144695558	144695559	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:144695558_144695559insG	ENST00000499587.2	+	0	178																											acgggggtgcaggggggaaagc	0.614													2	4	---	---	---	---					
LOC90768	90768	broad.mit.edu	37	4	182845568	182845568	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:182845568delG	ENST00000509012.1	-	0	378																											cttgtatgcagggtgaaatct	0.393													2	4	---	---	---	---					
LOC90768	90768	broad.mit.edu	37	4	183041310	183041311	+	RNA	INS	-	-	AG	rs142528808	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:183041310_183041311insAG	ENST00000509012.1	-	0	149																											TAGTCCCTTGAAGAGAGGTTCA	0.431													2	4	---	---	---	---					
LOC101928877	101928877	broad.mit.edu	37	4	186023868	186023868	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:186023868delG	ENST00000509017.1	+	0	1844																											CATATTTGCAGTTTCGAAGGG	0.557													3	4	---	---	---	---					
F11-AS1	285441	broad.mit.edu	37	4	187218904	187218905	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:187218904_187218905insC	ENST00000505103.1	-	0	153					NR_033900.1																						TAGTCTACCCACCCCCCCACAT	0.371													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190812561	190812561	+	RNA	DEL	A	A	-	rs78881180		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr4:190812561delA	ENST00000511785.1	-	0	231																											ttatgcttttatttttgcaaa	0.303													3	4	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9871360	9871360	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:9871360delA	ENST00000511616.1	-	0	521				RP11-447B18.1_ENST00000508097.1_lincRNA	NR_027112.2																						AAAGGGCAGGATCACCTCCCC	0.403													2	4	---	---	---	---					
RP11-124N3.2	0	broad.mit.edu	37	5	19036632	19036633	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:19036632_19036633insA	ENST00000513955.1	-	0	61				RP11-124N3.3_ENST00000504827.1_lincRNA																							GGGAAGGATTTAAGTTTATAGT	0.292													2	4	---	---	---	---					
CTD-2134P3.1	0	broad.mit.edu	37	5	28792169	28792169	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:28792169delT	ENST00000504398.1	-	0	294																											agggcaaaagttttttttcta	0.373													2	4	---	---	---	---					
CTD-2066L21.3	0	broad.mit.edu	37	5	33090079	33090079	+	RNA	DEL	T	T	-	rs112280481		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:33090079delT	ENST00000510327.1	-	0	346																											actggtgaagttttttttttt	0.423													4	3	---	---	---	---					
CTD-2066L21.3	0	broad.mit.edu	37	5	33297969	33297970	+	RNA	INS	-	-	G	rs71598990	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:33297969_33297970insG	ENST00000510327.1	-	0	46_47																											gactgggcaaagttttatagtc	0.540													4	2	---	---	---	---					
RP11-357F12.1	0	broad.mit.edu	37	5	45063537	45063537	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:45063537delA	ENST00000506656.1	+	0	78																											ggtgatggataagctaattac	0.308													2	4	---	---	---	---					
CTC-347C20.1	0	broad.mit.edu	37	5	72050280	72050281	+	RNA	INS	-	-	A	rs35402754		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:72050280_72050281insA	ENST00000513767.3	-	0	51																											gagttctctagaaaaaaaaaaa	0.396													3	3	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74261420	74261420	+	RNA	DEL	T	T	-	rs33988838		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:74261420delT	ENST00000505200.1	-	0	335																											gagtctaccctttgagGgcat	0.458													4	2	---	---	---	---					
RP11-168A11.1	0	broad.mit.edu	37	5	79243688	79243689	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:79243688_79243689insG	ENST00000503167.1	+	0	521																											TTTAGGAGGGAGGGGGGGCAGT	0.495													4	6	---	---	---	---					
LOC101927280	101927280	broad.mit.edu	37	5	117853092	117853093	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:117853092_117853093insG	ENST00000506769.1	-	0	2038																											ccatgagatttggggggaacac	0.431													2	4	---	---	---	---					
LINC01183	728586	broad.mit.edu	37	5	127254766	127254767	+	RNA	DEL	TG	TG	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:127254766_127254767delTG	ENST00000514853.2	+	0	591																											tgtgtatatatgtgtgtgtgtg	0.366													4	8	---	---	---	---					
DND1	373863	broad.mit.edu	37	5	140052285	140052285	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:140052285delT	ENST00000542735.1	-	3	392	c.349delA	c.(349-351)cgfs	p.T117fs		NM_194249.2	NP_919225.1	Q8IYX4	DND1_HUMAN	DND microRNA-mediated repression inhibitor 1	117	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding	p.T117fs*24(1)		central_nervous_system(1)|prostate(4)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGCAGCGTGGCGATGGCG	0.682													4	8	---	---	---	---					
CTD-2050E21.1	0	broad.mit.edu	37	5	142894875	142894876	+	RNA	INS	-	-	ACACACAC	rs56153368	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:142894875_142894876insACACACAC	ENST00000340585.6	-	0	437																											TAATTGGGAAAacacacacaca	0.376													2	4	---	---	---	---					
CTB-57H20.1	0	broad.mit.edu	37	5	143105781	143105781	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:143105781delA	ENST00000503323.1	+	0	379																											tgcaaaaaagaaaaaaaaatt	0.537													3	4	---	---	---	---					
CTC-295J13.3	0	broad.mit.edu	37	5	147620183	147620183	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:147620183delA	ENST00000513133.1	+	0	77																											GTCACCTGTTAAAAAAACTGA	0.338													2	4	---	---	---	---					
LOC101927766	101927766	broad.mit.edu	37	5	159259615	159259616	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:159259615_159259616insT	ENST00000522627.1	-	0	3691																											CAATGAGGCAGTTTGGTCAGAA	0.416													2	4	---	---	---	---					
FAM196B	100131897	broad.mit.edu	37	5	169310671	169310672	+	Frame_Shift_Ins	INS	-	-	G	rs138830175	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr5:169310671_169310672insG	ENST00000377365.3	-	2	1612_1613	c.231_232insC	c.(229-234)cccctafs	p.L78fs	DOCK2_ENST00000256935.8_Intron|DOCK2_ENST00000523351.1_Intron|DOCK2_ENST00000540750.1_Intron|DOCK2_ENST00000520908.1_Intron	NM_001129891.1	NP_001123363.1	A6NMK8	F196B_HUMAN	family with sequence similarity 196, member B	78										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)|skin(1)	5						AGCGAGTAGGTGGGGGGAAGAT	0.550													2	4	---	---	---	---					
RP11-532F6.4	0	broad.mit.edu	37	6	736343	736345	+	RNA	DEL	TTT	TTT	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:736343_736345delTTT	ENST00000607644.1	+	0	243																											TTGttttttgttttttttttttt	0.527													2	4	---	---	---	---					
RP1-167F1.2	0	broad.mit.edu	37	6	19633715	19633716	+	RNA	DEL	AC	AC	-	rs149956944		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:19633715_19633716delAC	ENST00000432171.2	-	0	366																											acagacacagacacacacacac	0.351													2	4	---	---	---	---					
C6orf183	389422	broad.mit.edu	37	6	109527945	109527945	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:109527945delG	ENST00000417143.3	+	0	1278																											gctaatttttgtatttttagt	0.537													2	4	---	---	---	---					
TULP4	56995	broad.mit.edu	37	6	158705551	158705552	+	RNA	DEL	GA	GA	-	rs77284831		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr6:158705551_158705552delGA	ENST00000432358.1	+	0	116																											cgccgtgaatgagagtcagcTT	0.450													4	3	---	---	---	---					
AC004540.5	0	broad.mit.edu	37	7	26506726	26506726	+	RNA	DEL	T	T	-	rs34530363		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:26506726delT	ENST00000418758.2	+	0	468																											aagcaaagacttttttttttt	0.423													7	3	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34658282	34658282	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:34658282delA	ENST00000419766.1	-	0	160					NR_033664.1|NR_033665.1																						ATCTTTAGATAAAAGCTCTCT	0.303													4	2	---	---	---	---					
LINC01448	101928795	broad.mit.edu	37	7	42727090	42727091	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:42727090_42727091insT	ENST00000455947.1	-	0	217																											CGTTAGAAATATTTTAGCAAAA	0.401													2	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89733144	89733144	+	RNA	DEL	T	T	-	rs3066768		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:89733144delT	ENST00000478318.2	-	0	424																											TCTTCAGTAGTTTTTTTTTTT	0.343													5	1	---	---	---	---					
RP11-142A5.1	0	broad.mit.edu	37	7	91011842	91011842	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:91011842delT	ENST00000456952.1	-	0	112																											gatacatagcttttggtggca	0.383													2	4	---	---	---	---					
AC006378.2	0	broad.mit.edu	37	7	93635257	93635257	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:93635257delA	ENST00000426634.1	+	0	481																											TGCTAGTATCAAATTAGGATA	0.299													2	4	---	---	---	---					
GPC2	221914	broad.mit.edu	37	7	99769524	99769525	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:99769524_99769525insG	ENST00000292377.2	-	7	1214_1215	c.1047_1048insC	c.(1045-1050)ccacccfs	p.P350fs	GPC2_ENST00000471050.1_5'UTR	NM_152742.1	NP_689955.1	Q8N158	GPC2_HUMAN	glypican 2	350						anchored to membrane|endoplasmic reticulum|extracellular space|plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(3)	18	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGCACCGGGTCGGGGGGGCCGC	0.723													2	4	---	---	---	---					
LINC01004	100216546	broad.mit.edu	37	7	104618318	104618318	+	RNA	DEL	C	C	-	rs67665940	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:104618318delC	ENST00000450686.1	-	0	113																											Ctttttttttctttctttttt	0.473													2	4	---	---	---	---					
RP11-328J2.1	0	broad.mit.edu	37	7	119393996	119393996	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:119393996delG	ENST00000426413.1	-	0	216																											GAATGGTGGTGGGGGGAAAGG	0.363													2	4	---	---	---	---					
RP11-114L10.2	0	broad.mit.edu	37	7	142588377	142588378	+	RNA	INS	-	-	CA	rs59168085		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr7:142588377_142588378insCA	ENST00000438839.1	+	0	99																											acaccccataccacacacacac	0.515													7	12	---	---	---	---					
RP11-145O15.3	0	broad.mit.edu	37	8	13438510	13438511	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:13438510_13438511insC	ENST00000529018.1	-	0	74																											ttatcagctttcccccatgtag	0.450													2	4	---	---	---	---					
RP11-13N12.2	0	broad.mit.edu	37	8	16521001	16521001	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:16521001delT	ENST00000521055.1	+	0	401																											aaagaaggtgttttttttttt	0.313													3	4	---	---	---	---					
RP11-13N12.1	0	broad.mit.edu	37	8	16726588	16726589	+	RNA	INS	-	-	G	rs116544264	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:16726588_16726589insG	ENST00000521411.2	-	0	127																											GGCTATTTTGTGGGGGGAAACC	0.421													2	4	---	---	---	---					
RP11-13N12.1	0	broad.mit.edu	37	8	16745979	16745979	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:16745979delT	ENST00000521411.2	-	0	127																											attaactatctttttttctgt	0.328													2	4	---	---	---	---					
LOC100507651	100507651	broad.mit.edu	37	8	58138797	58138797	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:58138797delA	ENST00000519160.1	+	0	863					NR_038235.1																						tgtctgatttaaaaaaaaaaa	0.398													4	6	---	---	---	---					
RP11-388G22.1	0	broad.mit.edu	37	8	58561838	58561839	+	RNA	DEL	GT	GT	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:58561838_58561839delGT	ENST00000520426.1	-	0	273																											CCAGGGTGGGgtgtgtgtgtgt	0.470													4	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	65275097	65275098	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:65275097_65275098insA	ENST00000521958.1	-	0	218				RP11-32K4.1_ENST00000523191.1_RNA																							AGAGTATGGAGAAAAATGAGTC	0.351													2	4	---	---	---	---					
LINC01592	100505718	broad.mit.edu	37	8	69883872	69883873	+	RNA	DEL	CT	CT	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:69883872_69883873delCT	ENST00000518540.1	-	0	415					NR_039986.1																						CTTTCATTTACTCTCTCTCTCT	0.376													2	4	---	---	---	---					
LOC101929709	101929709	broad.mit.edu	37	8	90746061	90746062	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:90746061_90746062insA	ENST00000504145.1	-	0	667																											atccctacctcaaaaaaatgga	0.327													3	4	---	---	---	---					
LINC00535	642924	broad.mit.edu	37	8	94463057	94463058	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:94463057_94463058insG	ENST00000501400.1	-	0	1133					NR_033858.1																						gactggattatgggggtggttt	0.455													3	6	---	---	---	---					
KB-1930G5.3	0	broad.mit.edu	37	8	102401285	102401285	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:102401285delA	ENST00000518612.1	-	0	157																											ATGATGTGAGAACCACTGTGG	0.512													2	4	---	---	---	---					
KB-1930G5.4	0	broad.mit.edu	37	8	102463849	102463849	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:102463849delT	ENST00000519793.1	-	0	242																											TTCTCTGCTGTTTTTCTCTTC	0.333													2	4	---	---	---	---					
RP11-369K17.1	0	broad.mit.edu	37	8	121977133	121977134	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr8:121977133_121977134insA	ENST00000517739.1	+	0	95																											caaggcagcagaaaaaaaggtc	0.525													2	4	---	---	---	---					
RP11-384P7.5	0	broad.mit.edu	37	9	33722537	33722538	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:33722537_33722538insG	ENST00000449144.1	+	0	1128_1129																											GTGAACATGGTggggccgcaca	0.431											OREG0019142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	3	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68408397	68408397	+	RNA	DEL	C	C	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:68408397delC	ENST00000417843.2	-	0	67																											tattataacactatagctgtg	0.299													2	4	---	---	---	---					
UNQ6494	100129066	broad.mit.edu	37	9	92316699	92316700	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:92316699_92316700insC	ENST00000444374.1	+	0	134_135																											AGTCCAGCTTGCCCCCCAGGCA	0.569													2	4	---	---	---	---					
RP11-308N19.1	0	broad.mit.edu	37	9	109195590	109195591	+	RNA	DEL	GT	GT	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:109195590_109195591delGT	ENST00000435485.1	+	0	171																											gtttgtgtacgtgtgtgtgtgt	0.361													4	7	---	---	---	---					
RP11-18B16.2	0	broad.mit.edu	37	9	116420160	116420161	+	RNA	DEL	CA	CA	-	rs71943401		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:116420160_116420161delCA	ENST00000428292.1	+	0	273																											gtacacattgcacacacacaca	0.416													2	4	---	---	---	---					
RP11-343J18.2	0	broad.mit.edu	37	9	128865315	128865315	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:128865315delG	ENST00000441473.1	+	0	235																											tgagccacccgcccggccATT	0.557													2	4	---	---	---	---					
NUP214	8021	broad.mit.edu	37	9	134073007	134073008	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr9:134073007_134073008insC	ENST00000359428.5	+	29	4270_4271	c.4126_4127insC	c.(4126-4128)cccfs	p.P1376fs	NUP214_ENST00000451030.1_Frame_Shift_Ins_p.P1377fs|NUP214_ENST00000483497.2_Frame_Shift_Ins_p.P202fs|NUP214_ENST00000465486.2_3'UTR|NUP214_ENST00000411637.2_Frame_Shift_Ins_p.P1366fs			P35658	NU214_HUMAN	nucleoporin 214kDa	1376	11 X 5 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TAATTTTACTGCCCCCCCGGTG	0.545			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								8	156	---	---	---	---					
RP11-71J2.1	0	broad.mit.edu	37	10	55058208	55058208	+	RNA	DEL	T	T	-	rs34825731		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:55058208delT	ENST00000449272.1	-	0	74																											aaagaagctctccaatgacct	0.428													3	5	---	---	---	---					
HPSE2	60495	broad.mit.edu	37	10	100995502	100995503	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:100995502_100995503insG	ENST00000370552.3	-	1	116_117	c.57_58insC	c.(55-60)cccgtgfs	p.V20fs	HPSE2_ENST00000370546.1_Frame_Shift_Ins_p.V20fs|HPSE2_ENST00000370549.1_Frame_Shift_Ins_p.V20fs|HPSE2_ENST00000404542.1_Frame_Shift_Ins_p.V20fs	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	20					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GCTAGGCACGCGGGGGGGCGGG	0.594													8	69	---	---	---	---					
PPRC1	23082	broad.mit.edu	37	10	103906659	103906660	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:103906659_103906660insC	ENST00000278070.2	+	9	3949_3950	c.3910_3911insC	c.(3910-3912)cccfs	p.P1304fs	PPRC1_ENST00000370012.1_Frame_Shift_Ins_p.P271fs|PPRC1_ENST00000413464.2_Intron|PPRC1_ENST00000489648.1_Intron	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	1304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCGGAGCAGGACCCCCCCAAAA	0.569													9	165	---	---	---	---					
CASC2	255082	broad.mit.edu	37	10	119887516	119887517	+	RNA	DEL	CT	CT	-	rs111323932		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr10:119887516_119887517delCT	ENST00000435944.1	+	0	452				CASC2_ENST00000454857.1_RNA|CASC2_ENST00000439517.1_RNA|CASC2_ENST00000414722.1_RNA	NR_026939.1																						attcaccacgctctctctctct	0.470													4	9	---	---	---	---					
LOC101927708	101927708	broad.mit.edu	37	11	3535642	3535642	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:3535642delT	ENST00000527970.1	-	0	285				RP13-726E6.1_ENST00000534291.1_lincRNA																							gtgtttcttattttttttttt	0.358													2	4	---	---	---	---					
ZBED5-AS1	729013	broad.mit.edu	37	11	10922791	10922791	+	RNA	DEL	T	T	-	rs34115710		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:10922791delT	ENST00000530344.1	+	0	67																											CTGCTACTTCTTTTTTTTTTT	0.353													4	3	---	---	---	---					
RP11-587D21.4	0	broad.mit.edu	37	11	27819686	27819686	+	RNA	DEL	T	T	-	rs61060130		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:27819686delT	ENST00000530663.1	-	0	147																											gtgaccatgcttttttttttt	0.443													2	4	---	---	---	---					
RP11-574M7.1	0	broad.mit.edu	37	11	50273181	50273181	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:50273181delA	ENST00000528459.1	+	0	47																											cccaggtatgaagctgacttg	0.358													2	4	---	---	---	---					
RP11-727A23.10	0	broad.mit.edu	37	11	83101371	83101372	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:83101371_83101372insG	ENST00000530045.1	+	0	537																											GGTGAGGGAATGGGGGGAAGAG	0.450													4	5	---	---	---	---					
RP11-64D24.2	0	broad.mit.edu	37	11	114126441	114126442	+	RNA	DEL	AA	AA	-	rs112668673		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:114126441_114126442delAA	ENST00000544925.1	-	0	56																											GACAAGATTTaaaaaaaaaaaa	0.366													3	5	---	---	---	---					
LOC100507431	100507431	broad.mit.edu	37	11	130715753	130715754	+	RNA	DEL	AC	AC	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr11:130715753_130715754delAC	ENST00000533812.2	-	0	1357																											acacacaggaacacacacacac	0.366													2	4	---	---	---	---					
RP11-1038A11.3	0	broad.mit.edu	37	12	5444875	5444876	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:5444875_5444876insC	ENST00000537192.1	+	0	219																											aaagctagtttccccccaaact	0.495													4	4	---	---	---	---					
LOC101930452	101930452	broad.mit.edu	37	12	9538980	9538981	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:9538980_9538981insC	ENST00000567749.1	+	0	2362																											tccctcattggccccccaaagt	0.421													2	4	---	---	---	---					
RP11-405A12.2	0	broad.mit.edu	37	12	19936739	19936740	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:19936739_19936740insG	ENST00000535764.1	+	0	153																											ggcgtgtgtgcggggggcgcgg	0.629													2	4	---	---	---	---					
RP11-625L16.1	0	broad.mit.edu	37	12	24862235	24862236	+	RNA	INS	-	-	A	rs147060691	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:24862235_24862236insA	ENST00000536131.1	+	0	192																											aaagaacacacaaaaaacccca	0.416													5	5	---	---	---	---					
RP11-1060J15.4	0	broad.mit.edu	37	12	27857675	27857675	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:27857675delT	ENST00000536317.1	-	0	354				RP11-1060J15.4_ENST00000542660.1_RNA|RP11-1060J15.7_ENST00000538640.1_lincRNA																							ACTCACCATGTTTTTTTTTCA	0.274													2	4	---	---	---	---					
RP11-946L16.1	0	broad.mit.edu	37	12	29298545	29298546	+	RNA	INS	-	-	G	rs11430679	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:29298545_29298546insG	ENST00000553075.1	-	0	140																											gcagggggcatggggggggtgg	0.589													3	4	---	---	---	---					
RP11-630C16.2	0	broad.mit.edu	37	12	42273209	42273209	+	RNA	DEL	C	C	-	rs35336592		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:42273209delC	ENST00000550874.1	-	0	471																											gggggaactgcccccatgatc	0.453													2	4	---	---	---	---					
RP11-630C16.2	0	broad.mit.edu	37	12	42308537	42308538	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:42308537_42308538insA	ENST00000550874.1	-	0	471																											gctgtgtccccacccaaatctc	0.465													2	4	---	---	---	---					
FLJ12825	440101	broad.mit.edu	37	12	54497545	54497546	+	RNA	INS	-	-	T	rs144888465	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:54497545_54497546insT	ENST00000515617.1	+	0	311					NR_026655.1																						ctgttctcttctgaatgccctt	0.525													7	2	---	---	---	---					
IKZF4	64375	broad.mit.edu	37	12	56429092	56429093	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:56429092_56429093insG	ENST00000262032.5	+	12	2102_2103	c.1735_1736insG	c.(1735-1737)gggfs	p.G579fs	IKZF4_ENST00000547791.1_Frame_Shift_Ins_p.G534fs|IKZF4_ENST00000547167.1_Frame_Shift_Ins_p.G579fs|IKZF4_ENST00000431367.2_Frame_Shift_Ins_p.G477fs|RP11-603J24.4_ENST00000551846.1_RNA			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	579					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCACATTGTCCGGGGGGAGCAT	0.554													12	351	---	---	---	---					
ESYT1	23344	broad.mit.edu	37	12	56531341	56531342	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:56531341_56531342insG	ENST00000394048.5	+	18	2261_2262	c.1997_1998insG	c.(1996-1998)tggfs	p.W666fs	ESYT1_ENST00000541590.1_Frame_Shift_Ins_p.W676fs|ESYT1_ENST00000267113.4_Frame_Shift_Ins_p.W676fs	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	666	C2 3.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						GACCGTTTCTTGGGGGGACTGG	0.550													7	331	---	---	---	---					
RP11-123O10.4	0	broad.mit.edu	37	12	67311728	67311729	+	RNA	DEL	AC	AC	-	rs72539115		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:67311728_67311729delAC	ENST00000535721.1	-	0	113																											agatgtataaacacacacacac	0.411													5	1	---	---	---	---					
RP11-13A1.3	0	broad.mit.edu	37	12	89524722	89524723	+	RNA	DEL	CA	CA	-	rs111330847		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:89524722_89524723delCA	ENST00000549278.1	-	0	144																											TACATGCCAGcacacacacaca	0.406													2	4	---	---	---	---					
RP11-554D14.6	0	broad.mit.edu	37	12	108240572	108240573	+	RNA	DEL	GA	GA	-	rs35520530		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:108240572_108240573delGA	ENST00000547452.1	-	0	326																											gacagagagggagagagagaga	0.520													2	4	---	---	---	---					
RP4-601P9.2	0	broad.mit.edu	37	12	115198533	115198534	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:115198533_115198534insG	ENST00000551875.1	+	0	656																											GGCATCTCTCTGGGGGCTGCTT	0.505													2	4	---	---	---	---					
FAM101A	144347	broad.mit.edu	37	12	124577498	124577499	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:124577498_124577499insG	ENST00000540762.1	+	0	247																											atggtgatggtgtgatgatggt	0.446													3	4	---	---	---	---					
FAM101A	144347	broad.mit.edu	37	12	124755971	124755972	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr12:124755971_124755972insT	ENST00000540762.1	+	0	444																											cttcttcttccttttttttttg	0.500													2	4	---	---	---	---					
RP11-141M1.3	0	broad.mit.edu	37	13	34053851	34053852	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:34053851_34053852insG	ENST00000454681.2	-	0	226																											gactggatcttgggggtggatt	0.450													2	4	---	---	---	---					
LINC00444	100874174	broad.mit.edu	37	13	48480160	48480161	+	RNA	INS	-	-	T	rs144872979	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:48480160_48480161insT	ENST00000435617.1	-	0	145																											AATTAGAATGATTATTGTATCA	0.361													4	2	---	---	---	---					
RNASEH2B-AS1	100874255	broad.mit.edu	37	13	51460896	51460896	+	RNA	DEL	A	A	-	rs111619110		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:51460896delA	ENST00000596992.1	-	0	382				RNASEH2B-AS1_ENST00000601286.1_RNA|RNASEH2B-AS1_ENST00000454605.1_RNA|RNASEH2B-AS1_ENST00000593369.1_RNA|RNASEH2B-AS1_ENST00000593750.1_RNA|RNASEH2B-AS1_ENST00000594244.1_RNA																							tctactaattaaaaaaaaaga	0.313													3	3	---	---	---	---					
LINC00355	144766	broad.mit.edu	37	13	64599743	64599743	+	RNA	DEL	T	T	-	rs112254683		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:64599743delT	ENST00000456627.1	-	0	961																											tcaagttacctattaaggcag	0.502													5	1	---	---	---	---					
MIR4500HG	642345	broad.mit.edu	37	13	88256360	88256361	+	RNA	INS	-	-	AC	rs141443067	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:88256360_88256361insAC	ENST00000436290.2	-	0	128					NR_033829.1																						cacacacagggacacacacaca	0.470													2	4	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101523944	101523945	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr13:101523944_101523945insC	ENST00000457843.1	+	0	141					NR_047687.1																						cactgccaacgccccccaccac	0.411													2	4	---	---	---	---					
RP11-146E13.4	0	broad.mit.edu	37	14	19819748	19819749	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:19819748_19819749insC	ENST00000548109.1	+	0	72																											GTGCCTAGGTGCCCACCGGGGG	0.540													2	4	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38531809	38531810	+	RNA	DEL	AG	AG	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:38531809_38531810delAG	ENST00000554687.1	-	0	200				CTD-2058B24.2_ENST00000555342.1_RNA																							ggcagcaggcagagagagagag	0.450													2	4	---	---	---	---					
LINC00639	283547	broad.mit.edu	37	14	39412357	39412359	+	RNA	DEL	AGA	AGA	-	rs35539083		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:39412357_39412359delAGA	ENST00000553932.1	-	0	96																											AAACAGGTACAGAAGAAGGAGAA	0.404													5	3	---	---	---	---					
RP11-930O11.1	0	broad.mit.edu	37	14	56790050	56790051	+	RNA	INS	-	-	CCT	rs142698134	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:56790050_56790051insCCT	ENST00000558120.1	+	0	544																											GGCTCCTAGCACCTCCACCCCT	0.535													7	2	---	---	---	---					
RP11-72M17.1	0	broad.mit.edu	37	14	66737224	66737224	+	RNA	DEL	G	G	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:66737224delG	ENST00000556874.1	-	0	643																											AAAATGACTTGCCAGAAATTA	0.343													2	4	---	---	---	---					
CTD-2128A3.2	0	broad.mit.edu	37	14	85974426	85974426	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:85974426delA	ENST00000557547.1	-	0	110																											aaaacaagttaaaaaaaaaaa	0.348													2	4	---	---	---	---					
RP11-1070N10.5	0	broad.mit.edu	37	14	96093537	96093538	+	RNA	INS	-	-	G	rs35059507	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:96093537_96093538insG	ENST00000555032.1	+	0	120																											GGGCAGGTGCAGGCTAGGTCCT	0.475													6	0	---	---	---	---					
RP11-433J8.2	0	broad.mit.edu	37	14	97221532	97221533	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr14:97221532_97221533insC	ENST00000556669.1	+	0	188																											GATGTCAGGGTCCCCCCGTACA	0.584													4	9	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48283952	48283953	+	RNA	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:48283952_48283953insG	ENST00000560900.1	+	0	195																											CAGCAAGTTTTGGGGGGGACTG	0.465													3	6	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61698152	61698152	+	RNA	DEL	T	T	-	rs144658187		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:61698152delT	ENST00000559783.1	-	0	186																											ttctacagagtttttgcaata	0.274													2	4	---	---	---	---					
NTRK3-AS1	283738	broad.mit.edu	37	15	88812909	88812909	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr15:88812909delA	ENST00000569588.1	+	0	1275					NR_038229.1																						GTGGACCAGGAAGGACAGACC	0.597													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5405010	5405013	+	RNA	DEL	GAGA	GAGA	-	rs143059617		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:5405010_5405013delGAGA	ENST00000569895.1	+	0	304																											ATGTGTATATgagagagagagagg	0.485													4	4	---	---	---	---					
SRCAP	10847	broad.mit.edu	37	16	30733909	30733910	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:30733909_30733910insG	ENST00000262518.4	+	23	4117_4118	c.3732_3733insG	c.(3730-3735)gcggggfs	p.AG1244fs	SRCAP_ENST00000344771.4_Intron|SRCAP_ENST00000395059.2_Intron	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1244	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCGTGTCAGCAGGGGGGCAGCA	0.614													8	413	---	---	---	---					
SETD1A	9739	broad.mit.edu	37	16	30976302	30976303	+	Frame_Shift_Ins	INS	-	-	C	rs151298063		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:30976302_30976303insC	ENST00000262519.8	+	7	1925_1926	c.1239_1240insC	c.(1237-1242)ctccccfs	p.LP413fs		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	413	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						CCTCCTACCTGCCCCCCGAGCC	0.678													7	184	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58901260	58901260	+	RNA	DEL	A	A	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:58901260delA	ENST00000500117.1	+	0	679				RP11-700H13.1_ENST00000562304.1_lincRNA																							AGTGAATGACAAAAAAGATAT	0.368													2	4	---	---	---	---					
FAM65A	79567	broad.mit.edu	37	16	67576380	67576381	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:67576380_67576381insC	ENST00000540839.3	+	14	1971_1972	c.1751_1752insC	c.(1750-1752)accfs	p.T584fs	FAM65A_ENST00000379312.3_Frame_Shift_Ins_p.T568fs|CTD-2012K14.3_ENST00000563083.1_RNA|FAM65A_ENST00000428437.2_Frame_Shift_Ins_p.T578fs|FAM65A_ENST00000422602.2_Frame_Shift_Ins_p.T584fs|FAM65A_ENST00000042381.4_Frame_Shift_Ins_p.T564fs|CTD-2012K14.4_ENST00000564717.1_RNA			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	568	Pro-rich.					cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		AGTGCTCCAAGCCCCCTCACTC	0.535													7	1006	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80495727	80495727	+	RNA	DEL	T	T	-	rs66844438		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr16:80495727delT	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568776.1_RNA|RP11-525K10.3_ENST00000568819.1_RNA																							acaAGCAGTATTCTTGCCCAC	0.463													3	3	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579470	7579471	+	Frame_Shift_Ins	INS	-	-	G	rs56275308		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:7579470_7579471insG	ENST00000420246.2	-	4	348_349	c.216_217insC	c.(214-219)cctggcfs	p.G73fs	TP53_ENST00000413465.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000269305.4_Frame_Shift_Ins_p.G73fs|TP53_ENST00000455263.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000445888.2_Frame_Shift_Ins_p.G73fs|TP53_ENST00000359597.4_Frame_Shift_Ins_p.G73fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	73	Interaction with HRMT1L2.|Interaction with WWOX.		V -> E (in a sporadic cancer; somatic mutation).|V -> L (in sporadic cancers; somatic mutation).|V -> M (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.V73fs*76(11)|p.0?(8)|p.V73L(3)|p.G59fs*23(3)|p.R72fs*51(2)|p.V73M(2)|p.V73fs*9(1)|p.R65fs*38(1)|p.E68fs*76(1)|p.V73fs*50(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGGGCCACGGGGGGAGCAG	0.604		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	632	---	---	---	---					
TMEM220-AS1	101101775	broad.mit.edu	37	17	10639487	10639488	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:10639487_10639488insT	ENST00000583343.1	+	0	110				CTC-297N7.5_ENST00000583115.1_RNA|CTC-297N7.5_ENST00000583012.1_RNA|TMEM220-AS1_ENST00000580899.1_RNA|CTC-297N7.5_ENST00000584714.1_RNA|CTC-297N7.5_ENST00000581366.1_RNA|CTC-297N7.5_ENST00000579114.1_RNA																							GGGTGTGTGGGtttttttgttt	0.431													2	4	---	---	---	---					
TMEM220-AS1	101101775	broad.mit.edu	37	17	10639496	10639496	+	RNA	DEL	T	T	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:10639496delT	ENST00000583343.1	+	0	110				CTC-297N7.5_ENST00000583115.1_RNA|CTC-297N7.5_ENST00000583012.1_RNA|TMEM220-AS1_ENST00000580899.1_RNA|CTC-297N7.5_ENST00000584714.1_RNA|CTC-297N7.5_ENST00000581366.1_RNA|CTC-297N7.5_ENST00000579114.1_RNA																							GGtttttttgttttttttttt	0.428													2	4	---	---	---	---					
KRT18P55	284085	broad.mit.edu	37	17	26624333	26624334	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:26624333_26624334insA	ENST00000577198.1	-	0	524					NR_028334.1																						gactccgtctcaaaaaaaacat	0.421													2	4	---	---	---	---					
SMURF2P1	0	broad.mit.edu	37	17	28985771	28985772	+	RNA	INS	-	-	AGGA	rs28881798		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:28985771_28985772insAGGA	ENST00000578265.1	+	0	377																											gagaaagaaagaggaaggaagg	0.520													3	3	---	---	---	---					
CTB-91J4.1	0	broad.mit.edu	37	17	34444371	34444372	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr17:34444371_34444372insT	ENST00000592460.1	+	0	41																											TCTTGCTGCTGTTTTTTTTTCC	0.421													2	4	---	---	---	---					
CTD-2015H3.2	0	broad.mit.edu	37	18	1748538	1748538	+	RNA	DEL	A	A	-	rs60739518		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:1748538delA	ENST00000580524.1	+	0	408																											tccatctcagaaaaaaaaaaa	0.363													4	2	---	---	---	---					
RP11-703M24.5	0	broad.mit.edu	37	18	2817830	2817831	+	RNA	INS	-	-	A	rs145089305	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:2817830_2817831insA	ENST00000583546.1	-	0	308																											ctacaaaaaacaaaaaaaaatt	0.530													3	5	---	---	---	---					
RP11-636O21.1	0	broad.mit.edu	37	18	37455012	37455013	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:37455012_37455013insA	ENST00000585822.1	-	0	310																											TGCTTTCAATGCAGGCCCACCC	0.386													2	4	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	39951161	39951162	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:39951161_39951162insC	ENST00000593234.1	+	0	713					NR_046456.1																						agattttggtacccccatcatc	0.347													2	4	---	---	---	---					
CTIF	9811	broad.mit.edu	37	18	46284307	46284308	+	Frame_Shift_Ins	INS	-	-	G	rs111264927		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:46284307_46284308insG	ENST00000256413.3	+	8	897_898	c.602_603insG	c.(601-603)cggfs	p.R201fs	CTIF_ENST00000382998.4_Frame_Shift_Ins_p.R201fs	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	201	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding	p.P153L(1)|p.P201L(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						CAGAGACCTCCGGGGGGCAACA	0.629													7	67	---	---	---	---					
RP11-15F12.1	0	broad.mit.edu	37	18	46563091	46563092	+	RNA	DEL	TG	TG	-	rs112911720		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr18:46563091_46563092delTG	ENST00000584252.1	+	0	242																											tcagctaatttgtgtgtgtgtg	0.470													2	4	---	---	---	---					
CPAMD8	27151	broad.mit.edu	37	19	17081702	17081703	+	Splice_Site	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:17081702_17081703insG	ENST00000443236.1	-	18	2383_2384	c.2354_splice	c.e18+1	p.N785_splice	CPAMD8_ENST00000388925.4_3'UTR	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	738						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AGCCGTTACCTGGGGGGGTGCC	0.569													7	30	---	---	---	---					
LOC101927210	101927210	broad.mit.edu	37	19	29100811	29100811	+	RNA	DEL	A	A	-	rs35179564		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:29100811delA	ENST00000587961.1	+	0	417				AC005394.1_ENST00000585394.1_lincRNA|AC005616.1_ENST00000589999.1_RNA|AC005307.3_ENST00000592347.1_RNA																							ggttgctgccagctgaggaca	0.498													4	6	---	---	---	---					
LOC284395	284395	broad.mit.edu	37	19	29817774	29817774	+	RNA	DEL	C	C	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:29817774delC	ENST00000582581.1	-	0	2030					NR_040029.1																						acctcagcctcccaaatagct	0.502													2	4	---	---	---	---					
CTD-2050I18.1	0	broad.mit.edu	37	19	32037917	32037918	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:32037917_32037918insA	ENST00000593063.1	+	0	282																											cccatctctataaaaaaaatac	0.515													2	4	---	---	---	---					
CTC-512J12.4	0	broad.mit.edu	37	19	44917435	44917436	+	RNA	INS	-	-	TCCG			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:44917435_44917436insTCCG	ENST00000588655.1	-	0	488																											TTCtccttccttctttccttcc	0.416													2	4	---	---	---	---					
NUP62	23636	broad.mit.edu	37	19	50412810	50412811	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:50412810_50412811insC	ENST00000596217.1	-	2	2141_2142	c.254_255insG	c.(253-255)gacfs	p.D85fs	IL4I1_ENST00000341114.3_Intron|NUP62_ENST00000597029.1_Frame_Shift_Ins_p.D85fs|NUP62_ENST00000352066.3_Frame_Shift_Ins_p.D85fs|CTC-326K19.6_ENST00000451973.1_3'UTR|IL4I1_ENST00000595948.1_Intron|NUP62_ENST00000413454.1_Frame_Shift_Ins_p.D85fs|NUP62_ENST00000422090.2_Frame_Shift_Ins_p.D85fs|NUP62_ENST00000597723.1_Frame_Shift_Ins_p.D85fs			P37198	NUP62_HUMAN	nucleoporin 62kDa	85	15 X 9 AA approximate repeats.|Thr-rich.				carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|stomach(1)|urinary_tract(2)	19		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		AAAATCCAGTTCCCCCCGAAGC	0.579													9	170	---	---	---	---					
CTB-147C22.9	0	broad.mit.edu	37	19	51497716	51497717	+	RNA	INS	-	-	G	rs144670178	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:51497716_51497717insG	ENST00000594512.1	+	0	429																											CTATTTTCTAAAGATCCTAGTG	0.441													8	3	---	---	---	---					
SIGLEC8	27181	broad.mit.edu	37	19	51960886	51960887	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr19:51960886_51960887insG	ENST00000321424.3	-	2	627_628	c.561_562insC	c.(559-564)cctgatfs	p.D188fs	SIGLEC8_ENST00000340550.5_Intron|SIGLEC8_ENST00000430817.1_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	188	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CAGGAGATCATGGGGGGTGTCC	0.649													10	144	---	---	---	---					
NCOR1P1	149934	broad.mit.edu	37	20	26088971	26088971	+	RNA	DEL	A	A	-	rs76867961	by1000genomes	TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr20:26088971delA	ENST00000478176.1	-	0	150					NR_003678.1																						CAGTATGCTTAAAAAAAAAGA	0.338													4	2	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11051168	11051168	+	RNA	DEL	T	T	-	rs59377780		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:11051168delT	ENST00000470054.1	-	0	487									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		agaccttttgtttttatttac	0.393													3	5	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11069158	11069158	+	RNA	DEL	T	T	-	rs57408407		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:11069158delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gaataatatattaaaaaaaac	0.284													5	5	---	---	---	---					
LINC00649	100506334	broad.mit.edu	37	21	35343812	35343815	+	RNA	DEL	ACAC	ACAC	-	rs138324381		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr21:35343812_35343815delACAC	ENST00000427447.1	+	0	2944_2947					NR_038883.1																						AATCCTGCTAacacacacacacac	0.387													3	4	---	---	---	---					
LINC01422	101929539	broad.mit.edu	37	22	27301640	27301640	+	RNA	DEL	A	A	-	rs111657350		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:27301640delA	ENST00000438113.1	+	0	92																											agtaaaacttaaaaaaaaaaa	0.413													3	4	---	---	---	---					
RP11-375H17.1	0	broad.mit.edu	37	22	28116444	28116445	+	RNA	INS	-	-	A	rs34974312		TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:28116444_28116445insA	ENST00000417957.1	+	0	84																											tcgtctctactaaaaaaaaaaa	0.500													4	4	---	---	---	---					
ISX-AS1	101926957	broad.mit.edu	37	22	35436359	35436360	+	RNA	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chr22:35436359_35436360insC	ENST00000448318.4	-	0	686																											aagtgacttcacccccccatgc	0.455													4	4	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22984350	22984351	+	RNA	INS	-	-	A			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:22984350_22984351insA	ENST00000455399.1	-	0	82																											CTGAAATCCCCAAAAAAACTCA	0.460													2	4	---	---	---	---					
RP1-154K9.2	0	broad.mit.edu	37	X	42546190	42546191	+	RNA	DEL	AG	AG	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:42546190_42546191delAG	ENST00000411879.1	+	0	748																											agagaaagaaagagagagagag	0.470													3	6	---	---	---	---					
LINC01496	102723426	broad.mit.edu	37	X	51249651	51249651	+	RNA	DEL	C	C	-			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:51249651delC	ENST00000448761.1	-	0	58																											GTTACGTCATCCCTCTATTTT	0.343													2	4	---	---	---	---					
STARD8	9754	broad.mit.edu	37	X	67943519	67943520	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:67943519_67943520insC	ENST00000252336.6	+	12	2983_2984	c.2611_2612insC	c.(2611-2613)cccfs	p.P871fs	STARD8_ENST00000374597.3_Frame_Shift_Ins_p.P871fs|STARD8_ENST00000374599.3_Frame_Shift_Ins_p.P951fs	NM_014725.4	NP_055540.2	Q92502	STAR8_HUMAN	StAR-related lipid transfer (START) domain containing 8	871	START.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion	GTPase activator activity	p.A874fs*16(2)|p.A954fs*16(1)		NS(2)|breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(2)	50						AGAGGTGGCAGCCCCCCCAGCT	0.678													2	4	---	---	---	---					
RP4-537K23.4	0	broad.mit.edu	37	X	129033172	129033173	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:129033172_129033173insT	ENST00000432062.1	-	0	293																											agcctgggtcctttttgtgaaa	0.337													2	4	---	---	---	---					
GS1-256O22.5	0	broad.mit.edu	37	X	142461003	142461004	+	RNA	INS	-	-	T			TCGA-17-Z033-01A-01W-0746-08	TCGA-17-Z033-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	639aea7c-5a38-4641-bf0d-90a9ce8e2980	27a976e4-0721-4c0a-94e5-f4ffbc460e54	g.chrX:142461003_142461004insT	ENST00000431432.1	+	0	176																											AGCACTTTGCATTTGATTTAAT	0.292													2	4	---	---	---	---