Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR2A5	393046	broad.mit.edu	37	7	143748072	143748072	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:143748072G>C	ENST00000408906.2	+	1	612	c.578G>C	c.(577-579)tGg>tCg	p.W193S		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					GCTGACACCTGGCTCAACCAG	0.572000													97	268					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27805322	27805322	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:27805322C>T	ENST00000261716.3	+	6	925	c.406C>T	c.(406-408)Ctt>Ttt	p.L136F	TAOK1_ENST00000536202.1_Missense_Mutation_p.L136F	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	136	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			ACATGGTGCTCTTCAGGGATT	0.299000													8	35					0	0	1	0	0
C4orf50	389197	broad.mit.edu	37	4	5961120	5961120	+	Silent	SNP	C	C	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:5961120C>G	ENST00000531445.1	-	7	2281	c.2235G>C	c.(2233-2235)ccG>ccC	p.P745P	C4orf50_ENST00000324058.5_Silent_p.P271P			Q6ZRC1	CD050_HUMAN	chromosome 4 open reading frame 50	271										breast(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(2)|skin(3)|urinary_tract(1)	15						CTAACTCCAGCGGTGATTTAT	0.458000													20	47					0	0	1	0	0
ERMP1	79956	broad.mit.edu	37	9	5805697	5805697	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr9:5805697C>A	ENST00000339450.5	-	9	1726	c.1637G>T	c.(1636-1638)gGa>gTa	p.G546V	ERMP1_ENST00000543230.1_Missense_Mutation_p.G124V|ERMP1_ENST00000381506.3_Missense_Mutation_p.G322V|ERMP1_ENST00000214893.5_5'UTR	NM_024896.2	NP_079172.2	Q7Z2K6	ERMP1_HUMAN	endoplasmic reticulum metallopeptidase 1	546					proteolysis	endoplasmic reticulum membrane|integral to membrane	metal ion binding|metallopeptidase activity			endometrium(2)|kidney(1)|large_intestine(9)|lung(4)|ovary(1)|prostate(2)|skin(1)	20		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00115)|Lung(218;0.111)		CGAGCAAAGTCCTTGGTAAGT	0.438000													30	82					7.11191e-15	9.03805e-15	1	1	0
NAV3	89795	broad.mit.edu	37	12	78582417	78582417	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:78582417C>T	ENST00000397909.2	+	33	6088	c.5915C>T	c.(5914-5916)aCt>aTt	p.T1972I	NAV3_ENST00000552300.1_Intron|NAV3_ENST00000536525.2_Missense_Mutation_p.T1950I|NAV3_ENST00000266692.7_Missense_Mutation_p.T1773I|NAV3_ENST00000228327.6_Missense_Mutation_p.T1950I			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1972						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GATACATCCACTAGCCTTGGT	0.383000										HNSCC(70;0.22)			35	99					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905148	144905148	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chrX:144905148A>T	ENST00000370490.1	+	1	5460	c.1205A>T	c.(1204-1206)gAc>gTc	p.D402V	SLITRK2_ENST00000434188.2_Missense_Mutation_p.D402V|SLITRK2_ENST00000447897.2_Missense_Mutation_p.D402V|SLITRK2_ENST00000428560.2_Missense_Mutation_p.D402V|SLITRK2_ENST00000413937.2_Missense_Mutation_p.D402V			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	402						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					AGTTCTTTGGACTTACTGCAC	0.423000													21	19					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183682984	183682984	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:183682984C>A	ENST00000334444.6	-	14	2260	c.2020G>T	c.(2020-2022)Gac>Tac	p.D674Y	ABCC5_ENST00000265586.6_Missense_Mutation_p.D674Y	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	674	ABC transporter 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TCCGTCAGGTCGCTGCTGGGA	0.607000													16	48					5.3912e-06	5.82059e-06	1	1	0
MBD6	114785	broad.mit.edu	37	12	57920532	57920532	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:57920532C>T	ENST00000355673.3	+	7	1960	c.1604C>T	c.(1603-1605)cCt>cTt	p.P535L	MBD6_ENST00000431731.2_Missense_Mutation_p.P535L	NM_052897.3	NP_443129.3	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	535	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|urinary_tract(1)	31						GCTGGCTTCCCTGGGATGCTT	0.647000													5	16					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137787060	137787060	+	Missense_Mutation	SNP	C	C	A	rs138745459		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:137787060C>A	ENST00000327532.2	-	13	2127	c.1765G>T	c.(1765-1767)Gcc>Tcc	p.A589S		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	589						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						GGAGCGGGGGCGGACACCTGG	0.697000													16	42					3.5997e-14	4.43599e-14	1	1	0
NALCN	259232	broad.mit.edu	37	13	101944670	101944670	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:101944670C>A	ENST00000251127.6	-	8	928	c.847G>T	c.(847-849)Gtg>Ttg	p.V283L	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Missense_Mutation_p.V283L	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	283						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATGAGGAACACCCAGCCTTCC	0.473000													19	29					2.35188e-11	2.84089e-11	1	1	0
FCRL2	79368	broad.mit.edu	37	1	157736756	157736756	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:157736756C>T	ENST00000361516.3	-	7	1216	c.1168G>A	c.(1168-1170)Gat>Aat	p.D390N	FCRL2_ENST00000368181.4_Missense_Mutation_p.D106N|FCRL2_ENST00000392274.3_Missense_Mutation_p.D390N|FCRL2_ENST00000469986.1_Missense_Mutation_p.D137N	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	390					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTATAGCCATCAGGTCCTGAG	0.443000													36	134					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31325198	31325198	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr18:31325198G>A	ENST00000269197.5	+	12	5386	c.5386G>A	c.(5386-5388)Gtt>Att	p.V1796I		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1796					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						AGAGAGAAACGTTGAAATTCC	0.498000													36	75					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57358431	57358431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:57358431G>A	ENST00000314922.3	-	1	158	c.82C>T	c.(82-84)Cag>Tag	p.Q28*	RP11-17A4.2_ENST00000518662.1_RNA|PENK_ENST00000523051.1_Nonsense_Mutation_p.Q28*|PENK_ENST00000451791.2_Nonsense_Mutation_p.Q28*|PENK_ENST00000518770.1_Nonsense_Mutation_p.Q28*	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	28					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCGCAATCCTGGCTGCATTCG	0.657000													5	16					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28878696	28878696	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:28878696C>A	ENST00000337120.5	+	2	4275	c.984C>A	c.(982-984)gaC>gaA	p.D328E	SH2B1_ENST00000538342.1_5'UTR|SH2B1_ENST00000359285.5_Missense_Mutation_p.D328E|SH2B1_ENST00000395532.4_Missense_Mutation_p.D328E|SH2B1_ENST00000322610.8_Missense_Mutation_p.D328E|SH2B1_ENST00000545570.1_Missense_Mutation_p.D18E|SH2B1_ENST00000563674.1_Intron	NM_001145812.1|NM_015503.2	NP_001139284.1|NP_056318.2	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	328	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|PH.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						CTATCACAGACGTCCGGACAA	0.542000													5	124					1.024e-07	1.18979e-07	1	1	0
UGT2A2	574537	broad.mit.edu	37	4	70505119	70505119	+	Silent	SNP	A	A	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:70505119A>G	ENST00000457664.2	-	1	239	c.240T>C	c.(238-240)ttT>ttC	p.F80F	UGT2A1_ENST00000514019.1_Silent_p.F281F|UGT2A1_ENST00000286604.4_Intron|UGT2A1_ENST00000503640.1_Intron|UGT2A1_ENST00000512704.1_Intron	NM_001105677.2	NP_001099147.2																					GTATCACTTCAAAATTCACAG	0.368000													58	105					0	0	1	0	0
GIP	2695	broad.mit.edu	37	17	47038345	47038345	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:47038345G>C	ENST00000357424.2	-	5	455	c.355C>G	c.(355-357)Cca>Gca	p.P119A		NM_004123.2	NP_004114.1	P09681	GIP_HUMAN	gastric inhibitory polypeptide	119					energy reserve metabolic process|signal transduction	extracellular region|soluble fraction	hormone activity			lung(2)|skin(1)|stomach(1)	4						TTCTTGGCTGGGGAGCTGCAA	0.567000													4	10					0	0	1	0	0
OR2M3	127062	broad.mit.edu	37	1	248367126	248367126	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:248367126G>A	ENST00000456743.1	+	1	795	c.757G>A	c.(757-759)Gga>Aga	p.G253R		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AATGTACTATGGAGCAGCTTT	0.488000													64	191					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102661457	102661457	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:102661457A>T	ENST00000315274.6	-	9	1344	c.1277T>A	c.(1276-1278)gTt>gAt	p.V426D	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	426	Hemopexin-like 4.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		AACTGCATCAACTTTGTGGCC	0.358000													25	42					0	0	1	0	0
RTP1	132112	broad.mit.edu	37	3	186917762	186917762	+	Silent	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:186917762A>T	ENST00000312295.4	+	2	726	c.696A>T	c.(694-696)tcA>tcT	p.S232S	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	232					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		AGACGGGCTCAGGCTGGAACT	0.597000													34	98					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2602398	2602398	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:2602398C>T	ENST00000399655.1	+	7	1224	c.959C>T	c.(958-960)aCg>aTg	p.T320M	CACNA1C_ENST00000399634.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399638.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399637.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399641.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000402845.3_Missense_Mutation_p.T320M|CACNA1C_ENST00000399591.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399595.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399644.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399601.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399617.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399629.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399649.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000335762.5_Missense_Mutation_p.T320M|CACNA1C_ENST00000399603.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000480911.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000327702.7_Missense_Mutation_p.T320M|CACNA1C_ENST00000399621.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399606.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000399597.1_Missense_Mutation_p.T320M|CACNA1C_ENST00000344100.3_Missense_Mutation_p.T320M|CACNA1C_ENST00000347598.4_Missense_Mutation_p.T320M|CACNA1C_ENST00000406454.3_Missense_Mutation_p.T320M	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	320					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCGCTGGAAACGGGCCACGGG	0.602000													43	141					0	0	1	0	0
GJA8	2703	broad.mit.edu	37	1	147380358	147380358	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:147380358C>G	ENST00000240986.4	+	2	329	c.276C>G	c.(274-276)taC>taG	p.Y92*	GJA8_ENST00000369235.1_Nonsense_Mutation_p.Y92*	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	92					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					CCCTGATGTACGTGGGGCACG	0.657000													22	66					0	0	1	0	0
PLCL1	5334	broad.mit.edu	37	2	198968574	198968574	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:198968574C>T	ENST00000428675.1	+	5	3417	c.3019C>T	c.(3019-3021)Cat>Tat	p.H1007Y	PLCL1_ENST00000437704.2_Missense_Mutation_p.H909Y	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	1007					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	TGAAGAACTTCATAATTTGGG	0.353000													34	94					0	0	1	0	0
BPGM	669	broad.mit.edu	37	7	134346797	134346797	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:134346797G>T	ENST00000393132.2	+	3	1027	c.538G>T	c.(538-540)Ggc>Tgc	p.G180C	BPGM_ENST00000418040.1_Missense_Mutation_p.G180C|BPGM_ENST00000344924.3_Missense_Mutation_p.G180C	NM_199186.2	NP_954655.1	P07738	PMGE_HUMAN	2,3-bisphosphoglycerate mutase	180					glycolysis|respiratory gaseous exchange		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			breast(1)|endometrium(1)|lung(2)|stomach(1)	5						AGTATTACGTGGCAAAACCAT	0.453000													35	81					2.42023e-17	3.17493e-17	1	1	0
KRBA2	124751	broad.mit.edu	37	17	8273312	8273312	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:8273312C>A	ENST00000396267.1	-	2	1204	c.373G>T	c.(373-375)Ggt>Tgt	p.G125C	KRBA2_ENST00000331336.2_Missense_Mutation_p.G207C|RP11-849F2.5_ENST00000583963.1_RNA|RP11-849F2.7_ENST00000582471.1_3'UTR|RP11-849F2.5_ENST00000580537.1_RNA			Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	207					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(5)|stomach(1)|urinary_tract(1)	18						GTCCGCCCACCATGTCCAATA	0.418000													10	43					7.48243e-07	8.37483e-07	1	1	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10862786	10862786	+	RNA	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr21:10862786G>C	ENST00000559480.1	+	0	82																		p.A28T(1)		breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						GCAGTCTGGGGCTGAGGTGAA	0.572000													17	154					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45899438	45899438	+	Silent	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:45899438C>T	ENST00000418234.2	-	6	969	c.891G>A	c.(889-891)ggG>ggA	p.G297G	PPP1R13L_ENST00000360957.5_Silent_p.G297G	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	297	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TGCCGGTGCCCCCCAGTCCAT	0.697000													2	0					0	0	1	0	0
HDAC1	3065	broad.mit.edu	37	1	32793141	32793141	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:32793141C>T	ENST00000373548.3	+	6	583	c.499C>T	c.(499-501)Cac>Tac	p.H167Y	HDAC1_ENST00000373541.2_5'UTR|HDAC1_ENST00000490081.1_3'UTR	NM_004964.2	NP_004955.2	Q13547	HDAC1_HUMAN	histone deacetylase 1	167	Histone deacetylase.				anti-apoptosis|blood coagulation|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|histone H3 deacetylation|histone H4 deacetylation|negative regulation by host of viral transcription|negative regulation of androgen receptor signaling pathway|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytosol|NuRD complex|Sin3 complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|identical protein binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|RNA polymerase II transcription corepressor activity|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18		Breast(348;0.000523)|Lung NSC(340;0.000992)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Lung SC(1967;0.113)		KIRC - Kidney renal clear cell carcinoma(1967;0.138)	Vorinostat(DB02546)	TCCTAGGTATCACCAGAGGGT	0.582000													4	24					0	0	1	0	0
ZNF567	163081	broad.mit.edu	37	19	37209889	37209889	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:37209889A>G	ENST00000585696.1	+	3	1400	c.170A>G	c.(169-171)aAg>aGg	p.K57R	ZNF567_ENST00000392163.2_Missense_Mutation_p.K57R|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000536254.2_Missense_Mutation_p.K88R|ZNF567_ENST00000360729.4_Missense_Mutation_p.K57R|ZNF567_ENST00000588311.1_Missense_Mutation_p.K57R			Q8N184	ZN567_HUMAN	zinc finger protein 567	88	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GTGAAATTCAAGGAACACCAA	0.318000													8	14					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217285167	217285167	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:217285167G>T	ENST00000357276.4	+	5	1338	c.1008G>T	c.(1006-1008)atG>atT	p.M336I	SMARCAL1_ENST00000358207.5_Missense_Mutation_p.M336I	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	336					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GGCGATGCATGCTCATCTCCA	0.512000									Schimke Immuno-Osseous Dysplasia				11	50					3.07112e-06	3.37546e-06	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141245284	141245284	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:141245284C>A	ENST00000389484.3	-	58	10116	c.9145G>T	c.(9145-9147)Gac>Tac	p.D3049Y		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3049					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.D3049Y(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAATCAAAGTCTATAGCAATA	0.308000										TSP Lung(27;0.18)			5	19					0.000602214	0.00062795	1	1	0
MYOT	9499	broad.mit.edu	37	5	137213289	137213289	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:137213289C>G	ENST00000239926.4	+	4	986	c.612C>G	c.(610-612)gaC>gaG	p.D204E	MYOT_ENST00000421631.2_Missense_Mutation_p.D20E|MYOT_ENST00000515645.1_Missense_Mutation_p.D89E|RP11-381K20.2_ENST00000514616.1_RNA|MYOT_ENST00000509812.1_3'UTR	NM_006790.2	NP_006781.1	Q9UBF9	MYOTI_HUMAN	myotilin	204					muscle contraction	actin cytoskeleton|sarcolemma|sarcomere	actin binding|structural constituent of muscle			cervix(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTCAGGATGACAGTGGTGCAC	0.383000													20	27					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295636	20295636	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:20295636G>C	ENST00000315947.1	+	1	29	c.29G>C	c.(28-30)aGa>aCa	p.R10T	OR4N2_ENST00000568211.1_Missense_Mutation_p.R10T	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ACAGTGATAAGAGAATTCATC	0.383000													16	237					0	0	1	0	0
KANK4	163782	broad.mit.edu	37	1	62739507	62739507	+	Silent	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:62739507C>T	ENST00000371153.4	-	3	1647	c.1269G>A	c.(1267-1269)ttG>ttA	p.L423L	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	423										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						ACTCCCTGGTCAAGAGTCCAT	0.552000													48	86					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114288770	114288770	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:114288770A>C	ENST00000357077.4	+	42	11134	c.11081A>C	c.(11080-11082)aAa>aCa	p.K3694T	ANK2_ENST00000394537.3_Missense_Mutation_p.K1609T|ANK2_ENST00000510275.2_Missense_Mutation_p.K261T|ANK2_ENST00000264366.6_Missense_Mutation_p.K3661T|ANK2_ENST00000509550.1_Missense_Mutation_p.K785T|ANK2_ENST00000506722.1_Missense_Mutation_p.K1600T	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3661					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CACAAGCAGAAAGAGGAGCAA	0.428000													26	32					0	0	1	0	0
TRIM45	80263	broad.mit.edu	37	1	117654991	117654991	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:117654991G>T	ENST00000256649.4	-	6	2205	c.1679C>A	c.(1678-1680)tCt>tAt	p.S560Y	TRIM45_ENST00000369464.3_Missense_Mutation_p.S542Y|TRIM45_ENST00000369461.3_Missense_Mutation_p.S503Y	NM_025188.3	NP_079464.2	Q9H8W5	TRI45_HUMAN	tripartite motif containing 45	560						cytoplasm|nucleus	zinc ion binding	p.S560Y(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|prostate(1)	23	Lung SC(450;0.225)	all_cancers(81;0.000979)|all_lung(203;7.65e-05)|all_epithelial(167;0.000134)|Lung NSC(69;0.000389)		Lung(183;0.0537)|Colorectal(144;0.172)|LUSC - Lung squamous cell carcinoma(189;0.187)		TGTGCATTCAGATTTCTCATT	0.527000													33	122					6.05902e-23	8.21334e-23	1	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16838657	16838657	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:16838657G>T	ENST00000355661.3	-	11	1566	c.1556C>A	c.(1555-1557)aCc>aAc	p.T519N	PLEKHA7_ENST00000448080.2_Missense_Mutation_p.T519N|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.T519N|PLEKHA7_ENST00000532079.1_Intron			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	519					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						CTGCCACACGGTGCCATCCCG	0.662000													20	53					2.89027e-11	3.45699e-11	1	1	0
IRF9	10379	broad.mit.edu	37	14	24632300	24632300	+	Silent	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:24632300C>T	ENST00000396864.3	+	3	593	c.306C>T	c.(304-306)cgC>cgT	p.R102R	RP11-468E2.4_ENST00000558468.1_3'UTR|IRF9_ENST00000557894.1_5'UTR	NM_006084.4	NP_006075.3	Q00978	IRF9_HUMAN	interferon regulatory factor 9	102					interferon-gamma-mediated signaling pathway|response to virus|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|nucleoplasm	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|kidney(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16				GBM - Glioblastoma multiforme(265;0.00853)		AGAGGGGCCGCATGGATGTTG	0.542000													30	47					0	0	1	0	0
SLC12A8	84561	broad.mit.edu	37	3	124909323	124909323	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:124909323A>G	ENST00000423114.2	-	3	180	c.181T>C	c.(181-183)Ttc>Ctc	p.F61L	SLC12A8_ENST00000469902.1_Missense_Mutation_p.F32L|SLC12A8_ENST00000393469.4_Missense_Mutation_p.F32L|SLC12A8_ENST00000314584.7_5'UTR			A0AV02	S12A8_HUMAN	solute carrier family 12, member 8	32					potassium ion transport	integral to membrane	symporter activity			endometrium(2)|kidney(2)|lung(12)	16						TCCCACATGAACAGCTGGGTC	0.582000													33	91					0	0	1	0	0
WRAP53	55135	broad.mit.edu	37	17	7606726	7606726	+	Silent	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:7606726A>T	ENST00000316024.5	+	10	3917	c.1569A>T	c.(1567-1569)ccA>ccT	p.P523P	WRAP53_ENST00000534050.1_Silent_p.P490P|WRAP53_ENST00000431639.2_Silent_p.P523P|WRAP53_ENST00000396463.2_Silent_p.P523P|WRAP53_ENST00000457584.2_Silent_p.P523P			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	523					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						GGGGGGCGCCAGACTCCAGCA	0.582000													3	12					0	0	1	0	0
STIM2	57620	broad.mit.edu	37	4	27009159	27009159	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:27009159G>A	ENST00000382009.3	+	8	1514	c.1247G>A	c.(1246-1248)cGc>cAc	p.R416H	STIM2_ENST00000237364.5_Missense_Mutation_p.R416H|STIM2_ENST00000467087.1_Missense_Mutation_p.R329H|STIM2_ENST00000465503.1_Missense_Mutation_p.R329H|STIM2_ENST00000412829.2_Missense_Mutation_p.R416H|STIM2_ENST00000467011.1_Missense_Mutation_p.R329H	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	329					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				ttcTAGGTTCGCATGGCTCTG	0.383000													8	38					0	0	1	0	0
DCAF6	55827	broad.mit.edu	37	1	167973205	167973205	+	Silent	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:167973205A>T	ENST00000367840.3	+	9	1189	c.1095A>T	c.(1093-1095)ggA>ggT	p.G365G	DCAF6_ENST00000367843.3_Silent_p.G365G|DCAF6_ENST00000432587.2_Silent_p.G334G|DCAF6_ENST00000312263.6_Silent_p.G365G	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	365					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						GCAATAGAGGACGAGGAAGAT	0.378000													24	51					0	0	1	0	0
SCPEP1	59342	broad.mit.edu	37	17	55058573	55058573	+	Silent	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:55058573C>A	ENST00000262288.3	+	2	262	c.207C>A	c.(205-207)ccC>ccA	p.P69P	SCPEP1_ENST00000571898.1_3'UTR	NM_021626.2	NP_067639.1	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1	69					proteolysis	extracellular region	serine-type carboxypeptidase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	14	Breast(9;2.86e-08)					CAGAACTGCCCCTGGTCATGT	0.517000													3	19					6.4e-05	6.84912e-05	1	1	0
LATS2	26524	broad.mit.edu	37	13	21549230	21549230	+	Missense_Mutation	SNP	C	C	T	rs113238499		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:21549230C>T	ENST00000382592.4	-	8	3451	c.3046G>A	c.(3046-3048)Gaa>Aaa	p.E1016K	LATS2_ENST00000542899.1_Missense_Mutation_p.E1016K	NM_014572.2	NP_055387.2	Q9NRM7	LATS2_HUMAN	large tumor suppressor kinase 2	1016	AGC-kinase C-terminal.				cell division|G1/S transition of mitotic cell cycle|hippo signaling cascade|hormone-mediated signaling pathway|intracellular protein kinase cascade|mitosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity	microtubule organizing center|nucleus|spindle pole	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.E1016K(1)		breast(4)|central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(7)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(2)	45		all_cancers(29;4.74e-22)|all_epithelial(30;1.45e-18)|all_lung(29;4.69e-16)|Lung SC(185;0.0262)|Hepatocellular(188;0.244)		all cancers(112;0.000781)|Epithelial(112;0.00144)|OV - Ovarian serous cystadenocarcinoma(117;0.0183)|Lung(94;0.0375)|LUSC - Lung squamous cell carcinoma(192;0.104)		GTGCTACCTTCGCTGGCATCG	0.547000													20	34					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62493021	62493021	+	Silent	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:62493021C>T	ENST00000539111.2	-	1	133	c.66G>A	c.(64-66)ggG>ggA	p.G22G		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	22					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CTACTCGACCCCCAAACCCAG	0.607000													18	35					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112103015	112103015	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:112103015C>T	ENST00000457016.1	+	4	730	c.350C>T	c.(349-351)tCa>tTa	p.S117L	APC_ENST00000257430.4_Missense_Mutation_p.S117L|APC_ENST00000508376.2_Missense_Mutation_p.S117L			P25054	APC_HUMAN	adenomatous polyposis coli	117	Leu-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.S117L(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CCTATGGGTTCATTTCCAAGA	0.418000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			24	42					0	0	1	0	0
MMP1	4312	broad.mit.edu	37	11	102661456	102661456	+	Silent	SNP	A	A	T	rs147162223	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:102661456A>T	ENST00000315274.6	-	9	1345	c.1278T>A	c.(1276-1278)gtT>gtA	p.V426V	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	426	Hemopexin-like 4.				blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		AAACTGCATCAACTTTGTGGC	0.358000													24	42					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	145008878	145008878	+	Silent	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:145008878C>T	ENST00000322810.4	-	10	1546	c.1377G>A	c.(1375-1377)ctG>ctA	p.L459L	PLEC_ENST00000436759.2_Silent_p.L349L|PLEC_ENST00000356346.3_Silent_p.L308L|PLEC_ENST00000345136.3_Silent_p.L322L|PLEC_ENST00000357649.2_Silent_p.L326L|PLEC_ENST00000354589.3_Silent_p.L322L|PLEC_ENST00000527096.1_Silent_p.L345L|PLEC_ENST00000354958.2_Silent_p.L300L|PLEC_ENST00000398774.2_Silent_p.L290L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	459	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCTTAAACTTCAGGAACTGAG	0.652000													3	4					0	0	1	0	0
LINC01410	103352539	broad.mit.edu	37	9	66458297	66458297	+	RNA	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr9:66458297G>A	ENST00000424345.1	+	0	67																											CAAGAGCCCGGCCCAGCCAAG	0.731000													3	8					0	0	1	0	0
ZNF252P	286101	broad.mit.edu	37	8	146199251	146199251	+	RNA	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:146199251G>A	ENST00000426361.2	-	0	4933					NR_023392.1															endometrium(1)	1						GAACAAACATGGAGGAAAAAG	0.418000													2	3					0	0	1	0	0
RAB17	64284	broad.mit.edu	37	2	238486012	238486012	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:238486012T>C	ENST00000264601.3	-	4	952	c.323A>G	c.(322-324)aAg>aGg	p.K108R	RAB17_ENST00000538644.1_5'UTR|RAB17_ENST00000409822.1_5'UTR|RAB17_ENST00000409576.1_Intron	NM_022449.3	NP_071894.1	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	108					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)	4		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		CTGCTGAGCCTTGAGGAAGGA	0.522000													14	34					0	0	1	0	0
TMC3	342125	broad.mit.edu	37	15	81664999	81664999	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:81664999G>T	ENST00000558726.1	-	2	304	c.169C>A	c.(169-171)Cag>Aag	p.Q57K	TMC3_ENST00000359440.5_Missense_Mutation_p.Q57K			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	57						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						AGATCTTTCTGGAACTGTATA	0.458000													30	98					3.99451e-17	5.18436e-17	1	1	0
SOS1	6654	broad.mit.edu	37	2	39214707	39214707	+	Silent	SNP	A	A	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:39214707A>G	ENST00000426016.1	-	23	3503	c.3417T>C	c.(3415-3417)agT>agC	p.S1139S	SOS1_ENST00000402219.2_Silent_p.S1139S|SOS1_ENST00000395038.2_Silent_p.S1124S			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	1139					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				CTTTGGTTAAACTTATAGATG	0.398000									Noonan syndrome				12	25					0	0	1	0	0
GMPPA	29926	broad.mit.edu	37	2	220371144	220371144	+	Splice_Site	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:220371144G>T	ENST00000358215.3	+	12	1531	c.1162_splice	c.e12+1	p.G388_splice	GMPPA_ENST00000341142.3_Splice_Site_p.G388_splice|AC053503.11_ENST00000429882.1_RNA|GMPPA_ENST00000313597.5_Splice_Site_p.G388_splice|GMPPA_ENST00000373917.3_Splice_Site_p.G441_splice|GMPPA_ENST00000373908.1_Splice_Site_p.G388_splice	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	388					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CACCATCCTGGGTATGGCTTC	0.627000													8	13					2.74318e-10	3.2492e-10	1	1	0
LMBRD2	92255	broad.mit.edu	37	5	36136536	36136536	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:36136536C>A	ENST00000296603.4	-	6	1084	c.622G>T	c.(622-624)Gaa>Taa	p.E208*		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	208						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGAGGAATTTCCACCAAGCCA	0.428000													23	29					8.04996e-18	1.06749e-17	1	1	0
LRRTM1	347730	broad.mit.edu	37	2	80529445	80529445	+	Silent	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:80529445G>T	ENST00000295057.3	-	2	2156	c.1500C>A	c.(1498-1500)gcC>gcA	p.A500A	CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000540488.1_Intron|CTNNA2_ENST00000361291.4_Intron|LRRTM1_ENST00000409148.1_Silent_p.A500A|CTNNA2_ENST00000402739.4_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	500						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						TGATCACCAGGGCTCCCTCAA	0.547000										HNSCC(69;0.2)			11	29					0.00010058	0.000106702	1	1	0
SLC12A5	57468	broad.mit.edu	37	20	44672539	44672539	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:44672539G>A	ENST00000454036.1	+	11	1506	c.1430G>A	c.(1429-1431)gGg>gAg	p.G477E	SLC12A5_ENST00000243964.3_Missense_Mutation_p.G454E|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	477					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GTTCTGTTTGGGGCCTGCATT	0.562000													17	60					0	0	1	0	0
SLC7A2	6542	broad.mit.edu	37	8	17412585	17412585	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:17412585A>G	ENST00000470360.1	+	9	1423	c.1306A>G	c.(1306-1308)Att>Gtt	p.I436V	SLC7A2_ENST00000494857.1_Intron|SLC7A2_ENST00000522656.1_Intron|SLC7A2_ENST00000004531.10_Intron|SLC7A2_ENST00000398090.3_Missense_Mutation_p.I436V			P52569	CTR2_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	397					cellular amino acid metabolic process|ion transport	cytoplasm|integral to plasma membrane|membrane fraction	basic amino acid transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(8)|ovary(2)|skin(1)|stomach(1)	25				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	L-Lysine(DB00123)|L-Ornithine(DB00129)	TGCAGGGGTCATTTCTGGTAA	0.453000													23	38					0	0	1	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20569944	20569944	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:20569944C>G	ENST00000202677.6	-	18	2549	c.2407G>C	c.(2407-2409)Gga>Cga	p.G803R		NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	803					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						TTCACATGTCCTTTATTCTCT	0.378000													9	16					0	0	1	0	0
CPB1	1360	broad.mit.edu	37	3	148577707	148577707	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:148577707A>T	ENST00000491148.1	+	12	1506	c.1172A>T	c.(1171-1173)gAa>gTa	p.E391V	CPB1_ENST00000282957.4_Missense_Mutation_p.E391V|CPB1_ENST00000498639.1_3'UTR|RP11-680B3.2_ENST00000488190.1_RNA			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	391					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTCCTTCCAGAATCCCAGATC	0.517000													23	60					0	0	1	0	0
THAP11	57215	broad.mit.edu	37	16	67876864	67876864	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:67876864C>T	ENST00000303596.1	+	1	652	c.407C>T	c.(406-408)tCt>tTt	p.S136F	CENPT_ENST00000562787.1_Intron	NM_020457.2	NP_065190.2	Q96EK4	THA11_HUMAN	THAP domain containing 11	136	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|urinary_tract(1)	8		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		TCCTCACCCTCTGCCTCCACT	0.627000													8	13					0	0	1	0	0
ATP10A	57194	broad.mit.edu	37	15	25959177	25959177	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:25959177G>A	ENST00000356865.6	-	10	2099	c.1988C>T	c.(1987-1989)tCg>tTg	p.S663L		NM_024490.3	NP_077816.1	O60312	AT10A_HUMAN	ATPase, class V, type 10A	663					ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|breast(2)|endometrium(8)|kidney(2)|large_intestine(33)|liver(1)|lung(41)|ovary(3)|pancreas(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	103		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GGCGATGGCCGAGGTGGGCTG	0.672000													6	7					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43984326	43984326	+	Silent	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:43984326G>A	ENST00000282406.4	+	26	3974	c.3864G>A	c.(3862-3864)gtG>gtA	p.V1288V		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1288	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AGTGCAAAGTGAATCAAACTC	0.353000													12	30					0	0	1	0	0
ARHGAP27	201176	broad.mit.edu	37	17	43474364	43474364	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:43474364G>C	ENST00000532038.1	-	10	1338	c.1203C>G	c.(1201-1203)agC>agG	p.S401R	ARHGAP27_ENST00000376922.2_Missense_Mutation_p.S282R|ARHGAP27_ENST00000528384.1_Missense_Mutation_p.S255R|CTB-39G8.3_ENST00000592389.1_RNA|ARHGAP27_ENST00000428638.1_Missense_Mutation_p.S623R|ARHGAP27_ENST00000532891.2_Missense_Mutation_p.S601R|ARHGAP27_ENST00000455881.1_Missense_Mutation_p.S282R|ARHGAP27_ENST00000442348.1_Missense_Mutation_p.S596R			Q6ZUM4	RHG27_HUMAN	Rho GTPase activating protein 27	623					positive regulation of Cdc42 GTPase activity|receptor-mediated endocytosis|signal transduction	cytoplasm|membrane	Rac GTPase activator activity|SH3 domain binding			endometrium(4)|large_intestine(9)|lung(3)|skin(1)	17	Renal(3;0.0405)					TGCTGCTCTCGCTCTCCTCTG	0.652000													17	58					0	0	1	0	0
SDS	10993	broad.mit.edu	37	12	113831717	113831717	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:113831717G>T	ENST00000257549.4	-	7	880	c.758C>A	c.(757-759)gCc>gAc	p.A253D		NM_006843.2	NP_006834.2	P20132	SDHL_HUMAN	serine dehydratase	253					gluconeogenesis|L-serine catabolic process|pyruvate biosynthetic process	cytoplasm	L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|protein homodimerization activity|pyridoxal phosphate binding			large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(1)	11					L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	CTCAATGGCGGCCACAGCCTC	0.587000													24	53					2.44723e-14	3.04655e-14	1	1	0
DMAP1	55929	broad.mit.edu	37	1	44684806	44684806	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:44684806G>A	ENST00000372289.2	+	6	1062	c.799G>A	c.(799-801)Gac>Aac	p.D267N	DMAP1_ENST00000488433.1_3'UTR|DMAP1_ENST00000315913.5_Missense_Mutation_p.D267N|DMAP1_ENST00000361745.6_Missense_Mutation_p.D267N	NM_019100.4	NP_061973.1	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	267					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(166;0.155)					ACGCAGCCAGGACCTGCAGAA	0.597000													20	18					0	0	1	0	0
BBS9	27241	broad.mit.edu	37	7	33545232	33545232	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:33545232C>T	ENST00000242067.6	+	20	2794	c.2273C>T	c.(2272-2274)cCg>cTg	p.P758L	BBS9_ENST00000396127.2_Missense_Mutation_p.P723L|BBS9_ENST00000355070.2_Missense_Mutation_p.P753L|BBS9_ENST00000354265.4_Missense_Mutation_p.P723L|BBS9_ENST00000350941.3_Missense_Mutation_p.P718L	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	758					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding	p.P758Q(2)	BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			GCATTTCTGCCGCTACAAGAA	0.498000									Bardet-Biedl syndrome				24	74					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43577065	43577065	+	Silent	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:43577065C>A	ENST00000452443.2	-	7	955	c.951G>T	c.(949-951)acG>acT	p.T317T		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	317					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GGTCATAGTACGTATCGATGG	0.458000													21	55					6.21321e-17	7.97907e-17	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169484670	169484670	+	Splice_Site	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:169484670G>T	ENST00000256935.8	+	44	4547	c.4467_splice	c.e44+1	p.Q1489_splice	DOCK2_ENST00000520908.1_Splice_Site_p.Q981_splice|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Splice_Site_p.Q550_splice	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1489	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATGTCGCAGGTGAGTCTGG	0.567000													15	45					3.52763e-06	3.8426e-06	1	1	0
RPTOR	57521	broad.mit.edu	37	17	78704429	78704429	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:78704429G>A	ENST00000306801.3	+	5	939	c.577G>A	c.(577-579)Gtc>Atc	p.V193I	RPTOR_ENST00000537330.1_Missense_Mutation_p.V8I|RPTOR_ENST00000570891.1_Missense_Mutation_p.V193I|RPTOR_ENST00000544334.2_Missense_Mutation_p.V193I	NM_020761.2	NP_065812.1	Q8N122	RPTOR_HUMAN	regulatory associated protein of MTOR, complex 1	193					cell cycle arrest|cell growth|cellular response to amino acid stimulus|cellular response to nutrient levels|insulin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|positive regulation of TOR signaling cascade|TOR signaling cascade	cytosol|lysosome|TORC1 complex	protein complex binding	p.V193I(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(3)	44						GTCGATCTTCGTCTACGACTG	0.537000													18	54					0	0	1	0	0
LPGAT1	9926	broad.mit.edu	37	1	212002507	212002507	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:212002507C>A	ENST00000366997.4	-	2	358	c.132G>T	c.(130-132)caG>caT	p.Q44H	LPGAT1_ENST00000366996.1_Missense_Mutation_p.Q44H	NM_014873.2	NP_055688.1	Q92604	LGAT1_HUMAN	lysophosphatidylglycerol acyltransferase 1	44					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(81;0.00773)|all cancers(67;0.0765)|Epithelial(68;0.114)		CTCGAAGGGGCTGAAGTATAA	0.463000													15	40					2.32078e-09	2.72246e-09	1	1	0
COL17A1	1308	broad.mit.edu	37	10	105807838	105807838	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:105807838T>A	ENST00000353479.5	-	30	2542	c.2252A>T	c.(2251-2253)cAa>cTa	p.Q751L	COL17A1_ENST00000369733.3_Missense_Mutation_p.Q751L	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	751	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TCTTGGGCCTTGGTGTCCGTC	0.582000													98	219					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6889	6889	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chrM:6889G>A	ENST00000361624.2	+	1	986	c.986G>A	c.(985-987)gGa>gAa	p.329_329insE						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						CACACTCCACGGAAGCAATAT	0.478000													116	169					0	0	1	0	0
ZNF736	728927	broad.mit.edu	37	7	63796682	63796682	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:63796682G>C	ENST00000355095.4	+	3	371	c.49G>C	c.(49-51)Gag>Cag	p.E17Q	ZNF736_ENST00000423484.1_Missense_Mutation_p.E17Q	NM_001170905.1	NP_001164376.1	B4DX44	ZN736_HUMAN	zinc finger protein 736	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|stomach(1)|urinary_tract(1)	9						CTCCCCAGAAGAGTGGGAATG	0.423000													8	29					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149489172	149489172	+	RNA	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:149489172G>T	ENST00000378016.2	+	0	5417							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCTCAGGACGGCTGCCCCAAT	0.632000													4	8					1	1	1	1	0
LINC00595	414243	broad.mit.edu	37	10	80027183	80027183	+	RNA	SNP	C	C	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:80027183C>G	ENST00000461034.1	+	0	48																											ACACCCCTAGCCCAGGGTCTC	0.537000													2	4					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9243996	9243996	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:9243996G>A	ENST00000318602.7	-	19	2577	c.2270C>T	c.(2269-2271)aCa>aTa	p.T757I		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	757					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	GTCAGGGACTGTTACTCCTAC	0.517000													35	133					0	0	1	0	0
OR10A6	390093	broad.mit.edu	37	11	7949666	7949666	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:7949666G>T	ENST00000309838.2	-	1	543	c.544C>A	c.(544-546)Cca>Aca	p.P182T		NM_001004461.1	NP_001004461.1	Q8NH74	O10A6_HUMAN	olfactory receptor, family 10, subfamily A, member 6	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		AACACTGCTGGGGTTTCACAA	0.368000													25	81					1.5548e-18	2.08446e-18	1	1	0
PAPOLA	10914	broad.mit.edu	37	14	96993836	96993836	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:96993836A>G	ENST00000216277.8	+	5	621	c.401A>G	c.(400-402)tAt>tGt	p.Y134C	PAPOLA_ENST00000557471.1_Missense_Mutation_p.Y134C|PAPOLA_ENST00000392990.2_Missense_Mutation_p.Y134C|PAPOLA_ENST00000557320.1_Missense_Mutation_p.Y134C|PAPOLA_ENST00000554130.1_3'UTR	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	134					mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		ACCTCATTCTATGATAAGTTG	0.358000													7	7					0	0	1	0	0
WHSC1L1	54904	broad.mit.edu	37	8	38133995	38133995	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:38133995T>G	ENST00000317025.8	-	23	4408	c.3891A>C	c.(3889-3891)gaA>gaC	p.E1297D	WHSC1L1_ENST00000527502.1_Missense_Mutation_p.E1286D|WHSC1L1_ENST00000433384.2_Missense_Mutation_p.E1248D|RP11-513D5.5_ENST00000529325.1_RNA	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	1297					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			TTGCCTTCTCTTCATTTGTTG	0.418000			T	NUP98	AML								8	12					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29541192	29541192	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:29541192G>C	ENST00000389048.3	-	8	2531	c.1625C>G	c.(1624-1626)cCg>cGg	p.P542R	ALK_ENST00000498037.1_5'UTR|ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	542	MAM 2.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity	p.P542R(1)	ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	GCTCTTGATCGGTGCAGGAAA	0.473000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				11	58					0	0	1	0	0
SLC15A4	121260	broad.mit.edu	37	12	129299352	129299352	+	Silent	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:129299352G>A	ENST00000266771.5	-	2	849	c.810C>T	c.(808-810)tcC>tcT	p.S270S	SLC15A4_ENST00000539703.1_5'UTR	NM_145648.3	NP_663623.1	Q8N697	S15A4_HUMAN	solute carrier family 15 (oligopeptide transporter), member 4	270					oligopeptide transport|protein transport	integral to membrane|lysosomal membrane	peptide:hydrogen symporter activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|skin(1)	22	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.69e-06)|Epithelial(86;1.17e-05)|all cancers(50;5.07e-05)		TTCGCTTCTGGGAACAGCAGG	0.478000													18	51					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251219	129251219	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:129251219T>C	ENST00000296271.3	+	3	750	c.656T>C	c.(655-657)aTc>aCc	p.I219T		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	219					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	ATGATTATCATCTTTTTCTGC	0.562000													12	22					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96585677	96585677	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:96585677C>A	ENST00000389672.5	+	2	432	c.394C>A	c.(394-396)Ctt>Att	p.L132I	EPHA6_ENST00000470610.2_Missense_Mutation_p.L132I|EPHA6_ENST00000542517.1_Missense_Mutation_p.L38I	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	37	Ephrin-binding.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						AGTTGTGTTGCTTGATACAAC	0.249000													5	5					5.9392e-07	6.7091e-07	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			7	10					0.00621372	0.00642435	1	1	0
ABCF3	55324	broad.mit.edu	37	3	183909039	183909039	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:183909039G>A	ENST00000429586.2	+	16	1750	c.1565G>A	c.(1564-1566)tGt>tAt	p.C522Y	ABCF3_ENST00000292808.5_Missense_Mutation_p.C516Y|EIF2B5_ENST00000444495.1_Intron	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	522	ABC transporter 2.						ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTCGCATCTGTGTGGTAAGG	0.542000													31	82					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48576829	48576829	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:48576829T>C	ENST00000262384.3	-	7	2913	c.2677A>G	c.(2677-2679)Atg>Gtg	p.M893V	N4BP1_ENST00000565423.1_5'UTR	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	893					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TCCAACACCATGGCAGAAAGC	0.483000													45	69					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458167	45458167	+	RNA	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:45458167C>A	ENST00000548424.1	+	0	448																											TCCCGACATTCTGGACGAGAG	0.468000													28	64					4.15321e-07	4.73544e-07	1	1	0
KCNA6	3742	broad.mit.edu	37	12	4920770	4920770	+	Silent	SNP	A	A	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:4920770A>T	ENST00000433855.1	+	1	2429	c.1563A>T	c.(1561-1563)gcA>gcT	p.A521A	KCNA6_ENST00000280684.3_Silent_p.A521A	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	521						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GGGCCTATGCAGAGAAAAGAA	0.567000										HNSCC(72;0.22)			18	57					0	0	1	0	0
AKR1D1	6718	broad.mit.edu	37	7	137776536	137776536	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:137776536C>A	ENST00000242375.3	+	3	326	c.284C>A	c.(283-285)cCa>cAa	p.P95Q	AKR1D1_ENST00000468877.2_Intron|AKR1D1_ENST00000432161.1_Missense_Mutation_p.P95Q|AKR1D1_ENST00000411726.2_Missense_Mutation_p.P95Q	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	95					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						AATCATGTCCCAGAGATGGTC	0.443000													20	39					1.50039e-11	1.83048e-11	1	1	0
OXA1L	5018	broad.mit.edu	37	14	23239013	23239013	+	Silent	SNP	C	C	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:23239013C>G	ENST00000358043.5	+	4	723	c.405C>G	c.(403-405)gcC>gcG	p.A135A	OXA1L_ENST00000285848.5_Silent_p.A211A|OXA1L_ENST00000604262.1_Silent_p.A151A|OXA1L_ENST00000412791.1_Silent_p.A151A			Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	151					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		CAGTCTTTGCCCGCTGCCTGA	0.478000													23	422					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777693	123777693	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:123777693T>G	ENST00000321355.2	+	1	585	c.555T>G	c.(553-555)atT>atG	p.I185M		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TCCCTCTTATTAAACTCTCCT	0.373000													58	92					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769451	57769451	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:57769451C>A	ENST00000371030.2	+	1	3377	c.3377C>A	c.(3376-3378)tCc>tAc	p.S1126Y		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1126						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GACCCGTGTTCCCCCCTCCAG	0.672000													3	25					0.115264	0.11817	1	1	0
LOC100288069	100288069	broad.mit.edu	37	1	706330	706331	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:706330_706331insG	ENST00000428504.1	-	0	585					NR_033908.1																						CCACTGCCTGAGGGGGGGGAGG	0.609													2	4	---	---	---	---					
ESPNP	284729	broad.mit.edu	37	1	17030903	17030905	+	RNA	DEL	GAG	GAG	-	rs67156338		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:17030903_17030905delGAG	ENST00000492551.1	-	0	696					NR_026567.1																						AGAGATCGACGAGGAGGGGGCCT	0.640													5	3	---	---	---	---					
RP11-84A19.4	0	broad.mit.edu	37	1	32359609	32359609	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:32359609delA	ENST00000602889.1	-	0	485																											actccctctcaaaaaaaaaaa	0.413													3	5	---	---	---	---					
RP11-335E6.2	0	broad.mit.edu	37	1	63605814	63605815	+	RNA	DEL	TT	TT	-	rs35321041		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:63605814_63605815delTT	ENST00000455038.1	+	0	248																											CCAGCCTGCATTTTTTTTTTTT	0.351													5	5	---	---	---	---					
GNG12-AS1	100289178	broad.mit.edu	37	1	68481142	68481143	+	RNA	INS	-	-	T	rs55645029	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:68481142_68481143insT	ENST00000420587.1	+	0	134				GNG12-AS1_ENST00000414904.1_RNA|GNG12-AS1_ENST00000413628.1_RNA	NR_040077.1		Q6ZVV5	Q6ZVV5_HUMAN																			TTGTGTTCCTATTTTAGGTTTG	0.401													2	4	---	---	---	---					
RP4-651E10.4	0	broad.mit.edu	37	1	87085726	87085726	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:87085726delT	ENST00000456587.1	-	0	294																											gagtcatctcttttcctcata	0.368													2	4	---	---	---	---					
LINC01057	101928079	broad.mit.edu	37	1	95127535	95127535	+	RNA	DEL	A	A	-	rs34038557		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:95127535delA	ENST00000452922.1	-	0	808																											cccacaaaggaaaaaaaaaac	0.393													2	4	---	---	---	---					
LOC102606465	102606465	broad.mit.edu	37	1	101546427	101546428	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:101546427_101546428insT	ENST00000449473.1	+	0	661				RP11-421L21.3_ENST00000446527.1_RNA|RP11-421L21.3_ENST00000416329.1_RNA|RP11-421L21.3_ENST00000454721.1_RNA																							AGACAATTGTGTTTTTTTCCCT	0.391													2	4	---	---	---	---					
LOC440600	440600	broad.mit.edu	37	1	110839462	110839462	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:110839462delA	ENST00000449169.1	-	0	293					NR_036595.1																						GAACCTAAAGAAAAAACGTGG	0.408													2	4	---	---	---	---					
AL592494.5	0	broad.mit.edu	37	1	121182497	121182497	+	RNA	DEL	A	A	-	rs147643764		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:121182497delA	ENST00000417218.1	+	0	551																											gtctcaaaagaaaaaaaaaaa	0.393													3	4	---	---	---	---					
RP11-423O2.5	0	broad.mit.edu	37	1	142804874	142804874	+	RNA	DEL	T	T	-	rs140820497		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:142804874delT	ENST00000423385.1	-	0	356																											ATTTTGCTGCTTTTTTTTTTT	0.303													3	5	---	---	---	---					
RP11-782C8.2	0	broad.mit.edu	37	1	143144761	143144762	+	RNA	DEL	AT	AT	-	rs72470663		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:143144761_143144762delAT	ENST00000412204.2	-	0	2503				RP11-782C8.1_ENST00000438000.1_lincRNA																							tccctttaccatgggtttgaga	0.396													3	6	---	---	---	---					
SRGAP2B	647135	broad.mit.edu	37	1	143939946	143939947	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:143939946_143939947insT	ENST00000467933.1	+	0	915																											TTATGCAACACTTTTTTTTTGT	0.391													2	4	---	---	---	---					
SRGAP2B	647135	broad.mit.edu	37	1	144011657	144011658	+	RNA	INS	-	-	G	rs66670828		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:144011657_144011658insG	ENST00000467933.1	+	0	915																											GGttcttttttttgttgtttgt	0.520													4	4	---	---	---	---					
RNU1-120P	0	broad.mit.edu	37	1	147735878	147735879	+	RNA	INS	-	-	G	rs76706846	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:147735878_147735879insG	ENST00000363009.1	+	0	128_129																											tttgtggtagtggggggggctg	0.441													2	4	---	---	---	---					
RP11-297H3.3	0	broad.mit.edu	37	1	170186518	170186518	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:170186518delG	ENST00000439184.1	+	0	304																											TTTTAAGCCTGGTCCCATAGT	0.383													2	4	---	---	---	---					
LOC101928650	101928650	broad.mit.edu	37	1	170472432	170472433	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:170472432_170472433insG	ENST00000416416.1	-	0	113				RP11-576I22.2_ENST00000456083.1_RNA																							GACAAAAATTTGGGGTTTTGCT	0.376													2	4	---	---	---	---					
RP11-316I3.2	0	broad.mit.edu	37	1	188854355	188854355	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:188854355delA	ENST00000414765.1	-	0	194																											atatattgctaaaaagaaatt	0.294													2	4	---	---	---	---					
LOC440704	440704	broad.mit.edu	37	1	190689707	190689708	+	RNA	DEL	TT	TT	-	rs79554792		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:190689707_190689708delTT	ENST00000413356.1	+	0	144					NR_033922.1																						TATCCTTTCATTTTTTTTTTTG	0.332													2	4	---	---	---	---					
LINC01221	104266961	broad.mit.edu	37	1	199043197	199043198	+	RNA	DEL	GT	GT	-	rs71150944		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:199043197_199043198delGT	ENST00000432488.1	+	0	450																											ttgagtgtgagtgtgtgtgtgt	0.342													4	3	---	---	---	---					
LINC00862	554279	broad.mit.edu	37	1	200325321	200325324	+	RNA	DEL	AAAC	AAAC	-	rs138089019		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:200325321_200325324delAAAC	ENST00000367355.1	-	0	550					NR_040064.1																						CTCCAGCTGTAAACAGTCCTTCTG	0.402													2	4	---	---	---	---					
RP11-323I1.1	0	broad.mit.edu	37	1	213952906	213952906	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:213952906delA	ENST00000456240.1	+	0	143																											GTCGTGGTTTAAAAACTTGAT	0.403													2	4	---	---	---	---					
LOC101929771	101929771	broad.mit.edu	37	1	222009840	222009847	+	RNA	DEL	TGTGTGTG	TGTGTGTG	-	rs72320493		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:222009840_222009847delTGTGTGTG	ENST00000431729.1	-	0	277																											tgtgtgtgtttgtgtgtgtgtgtgtgtg	0.495													2	4	---	---	---	---					
RP11-400N13.1	0	broad.mit.edu	37	1	222403928	222403929	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr1:222403928_222403929insT	ENST00000416510.1	-	0	167																											GAAGTTTTTCATTTTTGCCACC	0.401													2	4	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	2956420	2956421	+	RNA	DEL	AG	AG	-	rs35770430		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:2956420_2956421delAG	ENST00000457478.1	-	0	594																											acagacagacagacagacacac	0.431													4	3	---	---	---	---					
LINC01248	102723818	broad.mit.edu	37	2	5753731	5753732	+	RNA	DEL	AC	AC	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:5753731_5753732delAC	ENST00000458264.1	-	0	302																											cattgttctaacacacacacac	0.371													2	4	---	---	---	---					
LOC100506457	100506457	broad.mit.edu	37	2	12464550	12464551	+	RNA	DEL	TG	TG	-	rs3056599		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:12464550_12464551delTG	ENST00000412294.1	+	0	412																											caatgatgtatgtgtgtgtgtg	0.416													2	4	---	---	---	---					
AC010745.2	0	broad.mit.edu	37	2	16407935	16407935	+	RNA	DEL	T	T	-	rs78167150		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:16407935delT	ENST00000420404.1	+	0	165																											CAGTCCCCCCTCTTCCCCAGT	0.557													2	4	---	---	---	---					
AC008069.1	0	broad.mit.edu	37	2	16911901	16911901	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:16911901delA	ENST00000448650.1	+	0	56																											tcccctccctagggaaaaaat	0.353													2	4	---	---	---	---					
LINC01376	400945	broad.mit.edu	37	2	19173565	19173566	+	RNA	INS	-	-	A	rs35877119	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:19173565_19173566insA	ENST00000424895.1	-	0	531																											aaaggaaaaacaaaaaaaaaga	0.342													2	4	---	---	---	---					
AC098828.2	0	broad.mit.edu	37	2	20271713	20271713	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:20271713delA	ENST00000430429.1	-	0	90																											CTTTGCTTCCAAAAAAAAAAG	0.433											OREG0004833	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	3	6	---	---	---	---					
AC067959.1	0	broad.mit.edu	37	2	21484848	21484848	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:21484848delA	ENST00000457901.1	+	0	110																											GAAAGACAGTAAAAAAAAAAA	0.428													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22679253	22679254	+	RNA	INS	-	-	T	rs75583714		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:22679253_22679254insT	ENST00000450551.1	-	0	70				AC096570.2_ENST00000419013.1_lincRNA																							CTGAACATATCTTTTTTTTTTT	0.342													2	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35106194	35106194	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:35106194delA	ENST00000588944.1	+	0	115																											atctcagaggaaaaaaaaaaa	0.433													4	3	---	---	---	---					
CYP1B1-AS1	285154	broad.mit.edu	37	2	38337268	38337268	+	RNA	DEL	A	A	-	rs113401938		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:38337268delA	ENST00000431999.1	+	0	420				CYP1B1-AS1_ENST00000593090.1_RNA|CYP1B1-AS1_ENST00000427168.2_RNA|CYP1B1-AS1_ENST00000589303.1_RNA																							GTCACCAACCAAAAAAAAAAA	0.473													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51342643	51342644	+	RNA	INS	-	-	TC	rs150439415	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:51342643_51342644insTC	ENST00000440698.1	+	0	514																											catgtctttggtctcattcaat	0.426													4	5	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51358142	51358142	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:51358142delT	ENST00000440698.1	+	0	514																											gcctgttgtgtcggaccaagt	0.413													4	2	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51406897	51406897	+	RNA	DEL	A	A	-	rs145085535		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:51406897delA	ENST00000440698.1	+	0	514																											ttaaaagaccaaaaaaaaaaa	0.348													2	4	---	---	---	---					
MIR217HG	104355290	broad.mit.edu	37	2	56234144	56234144	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:56234144delT	ENST00000606639.1	+	0	82				AC011306.2_ENST00000446139.1_lincRNA																							acttttaaacttttttttttt	0.363													4	2	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58697172	58697172	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:58697172delA	ENST00000452840.1	+	0	195																											TTTCCATCCTAATACATTCTG	0.393													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65762549	65762550	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:65762549_65762550insC	ENST00000377977.3	+	0	862																											ATGCCAGGAGGCCCCCCAAAGT	0.480													2	4	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65869833	65869834	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:65869833_65869834insA	ENST00000377977.3	+	0	862																											tccgtctcaggaaaaaaaaaaa	0.520													3	5	---	---	---	---					
SLC9B1P2	389000	broad.mit.edu	37	2	92085952	92085953	+	RNA	DEL	AT	AT	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:92085952_92085953delAT	ENST00000606405.1	-	0	167																											tcagtgaaacataaagggaggc	0.347													4	6	---	---	---	---					
LOC442028	442028	broad.mit.edu	37	2	95587173	95587173	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:95587173delA	ENST00000568768.1	-	0	476																											ttttgtctccaaaaaaaaaaG	0.443													3	3	---	---	---	---					
AC069394.1	0	broad.mit.edu	37	2	138862371	138862372	+	RNA	DEL	AA	AA	-	rs79815081		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:138862371_138862372delAA	ENST00000446520.1	+	0	124																											acttcatctcaaaaaaaaaaaa	0.416													2	4	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145676603	145676604	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:145676603_145676604insC	ENST00000445791.1	+	0	307					NR_033870.2																						tagtccccccacccccccgcat	0.366													2	4	---	---	---	---					
AC018731.3	0	broad.mit.edu	37	2	152008242	152008243	+	RNA	DEL	TC	TC	-	rs34430387	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:152008242_152008243delTC	ENST00000447078.1	-	0	90																											ATCCAATCCTTCTCTGTCTTTT	0.322													3	3	---	---	---	---					
AC009313.1	0	broad.mit.edu	37	2	161980754	161980754	+	RNA	DEL	C	C	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:161980754delC	ENST00000425470.1	-	0	165																											caagccctaacccccctaacc	0.393													2	4	---	---	---	---					
SLC4A10	57282	broad.mit.edu	37	2	162449091	162449091	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:162449091delT	ENST00000605990.1	+	0	344																											tgcccagctatttttttttta	0.428													3	3	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	165125431	165125431	+	RNA	DEL	C	C	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:165125431delC	ENST00000429636.1	-	0	104																											ttataagggaccagggatgga	0.443													2	4	---	---	---	---					
AC018890.6	0	broad.mit.edu	37	2	175634655	175634656	+	RNA	INS	-	-	A	rs138301183		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:175634655_175634656insA	ENST00000442996.1	+	0	321																											tctgtgtcattaaaaaaaaaaa	0.500													2	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208167467	208167468	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:208167467_208167468insA	ENST00000412387.1	-	0	315																											acataaaatagaaaaacatttc	0.272													2	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208212868	208212868	+	RNA	DEL	C	C	-	rs141129622		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:208212868delC	ENST00000418850.1	-	0	400				AC007879.5_ENST00000412387.1_RNA																							cagagacacacacaaaaaaaa	0.388													4	2	---	---	---	---					
LOC102724861	102724861	broad.mit.edu	37	2	216411158	216411158	+	RNA	DEL	G	G	-	rs59140748	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:216411158delG	ENST00000417485.2	+	0	216																											TTTTTGTTTTGTTTTGTTTTT	0.468													4	4	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217710059	217710060	+	RNA	INS	-	-	AGAA	rs10666026	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:217710059_217710060insAGAA	ENST00000447289.1	+	0	510																											GAGAGAGAGAGAGGGTGTCTTG	0.450													4	8	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217815494	217815494	+	RNA	DEL	C	C	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:217815494delC	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							CTCCAGTGGTCAGAGGTCAGA	0.522													2	4	---	---	---	---					
AC067956.1	0	broad.mit.edu	37	2	221385831	221385831	+	RNA	DEL	T	T	-	rs11315974		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:221385831delT	ENST00000414512.1	+	0	368																											TTCACGCACCttttttttttt	0.388													2	4	---	---	---	---					
AC009410.1	0	broad.mit.edu	37	2	229380756	229380757	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:229380756_229380757insA	ENST00000432481.2	-	0	144																											TTTCTTCTCAGAAAAAAAAATG	0.356													2	4	---	---	---	---					
AC009410.1	0	broad.mit.edu	37	2	229443910	229443911	+	RNA	DEL	TG	TG	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:229443910_229443911delTG	ENST00000432481.2	-	0	144																											tgtgtgtatatgtgtgtgtgtg	0.356													2	4	---	---	---	---					
AC105760.2	0	broad.mit.edu	37	2	237984097	237984097	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr2:237984097delT	ENST00000418430.1	-	0	1662																											TCAGGATAACTTCCCAGAGCC	0.393													2	4	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	624181	624182	+	RNA	INS	-	-	A	rs33927615	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:624181_624182insA	ENST00000420823.1	+	0	97																											TGGTTTGTTTTTTAGAACAAAT	0.282													5	2	---	---	---	---					
AC026188.1	0	broad.mit.edu	37	3	3426030	3426030	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:3426030delT	ENST00000455703.1	-	0	59																											GGGTAAGAGGTTTAAAGCATg	0.512													2	4	---	---	---	---					
LOC101927829	101927829	broad.mit.edu	37	3	20389718	20389718	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:20389718delT	ENST00000455626.1	+	0	1827																											TGCCTGTCAGTTTTGGGGAGA	0.383													2	4	---	---	---	---					
AC098973.2	0	broad.mit.edu	37	3	27916101	27916101	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:27916101delT	ENST00000414382.1	+	0	336																											GTTGTTAGCATTTTTTGACAC	0.428													2	4	---	---	---	---					
ITGA9-AS1	101928153	broad.mit.edu	37	3	37895761	37895762	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:37895761_37895762insG	ENST00000366441.2	-	0	65				AC093415.2_ENST00000457661.1_RNA|AC093415.2_ENST00000445429.1_RNA|AC093415.2_ENST00000438136.1_RNA|AC093415.2_ENST00000430620.1_RNA|AC093415.2_ENST00000420870.1_RNA|AC093415.2_ENST00000450990.1_RNA|AC093415.2_ENST00000429532.1_RNA																							CAGGGAATAAAGGGGGTACCTG	0.584													2	4	---	---	---	---					
AC136289.1	0	broad.mit.edu	37	3	63791625	63791626	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:63791625_63791626insT	ENST00000443346.1	-	0	622																											TTTTGGTTTTGTTTTTTTATAC	0.455													2	4	---	---	---	---					
ADAMTS9-AS2	100507098	broad.mit.edu	37	3	64688066	64688066	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:64688066delT	ENST00000460833.1	+	0	430				ADAMTS9-AS2_ENST00000474768.1_RNA|ADAMTS9-AS2_ENST00000485174.1_RNA|ADAMTS9-AS2_ENST00000481312.1_RNA																							CAAGTATTCATTTTCAGAGTG	0.393													2	4	---	---	---	---					
RP11-654C22.2	0	broad.mit.edu	37	3	72588945	72588945	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:72588945delA	ENST00000478745.1	-	0	582																											ttaaaaatttaaaaagatgag	0.413													2	4	---	---	---	---					
LINC01215	101929623	broad.mit.edu	37	3	107856950	107856951	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:107856950_107856951insC	ENST00000607746.1	+	0	2085_2086																											CTGAACACACACCACCCCACAC	0.347													2	4	---	---	---	---					
RP11-384F7.1	0	broad.mit.edu	37	3	117995547	117995548	+	RNA	DEL	CA	CA	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:117995547_117995548delCA	ENST00000482142.1	-	0	232																											CACACATATGCACACACACACA	0.347													2	4	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	147029603	147029604	+	RNA	INS	-	-	A	rs150998283	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:147029603_147029604insA	ENST00000473299.1	-	0	132																											TCAGAGAGGAGAAAAAAAAAAC	0.347													2	4	---	---	---	---					
RP11-501O2.4	0	broad.mit.edu	37	3	147953895	147953895	+	RNA	DEL	T	T	-	rs112962069		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:147953895delT	ENST00000460324.1	-	0	317																											GAATCGTAAATTTTTTTGCCT	0.408													4	3	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153136607	153136616	+	RNA	DEL	TTTTTTTTTT	TTTTTTTTTT	-	rs76065025		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:153136607_153136616delTTTTTTTTTT	ENST00000493214.2	-	0	381																											tatgaaattctttttttttttttttttttt	0.352													4	2	---	---	---	---					
IL12A-AS1	101928376	broad.mit.edu	37	3	159846716	159846716	+	RNA	DEL	T	T	-	rs78699964		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:159846716delT	ENST00000497452.1	-	0	517																											gtccttggacttttttttttt	0.438													2	4	---	---	---	---					
SAMD7	344658	broad.mit.edu	37	3	169646267	169646268	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:169646267_169646268insG	ENST00000428432.2	+	7	1331_1332	c.942_943insG	c.(940-945)atggggfs	p.MG314fs	SAMD7_ENST00000335556.3_Frame_Shift_Ins_p.MG314fs	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	314										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			TGGTTACAATTGGGGGGAATCT	0.381													8	132	---	---	---	---					
LINC00578	100505566	broad.mit.edu	37	3	177442580	177442580	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:177442580delG	ENST00000442937.1	+	0	428					NR_047568.1																						gcagtgcagagGCCTCCAACT	0.373													2	4	---	---	---	---					
LINC00888	100505687	broad.mit.edu	37	3	183172643	183172643	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr3:183172643delT	ENST00000471496.1	+	0	675					NR_038302.1																						GTGCCTGGTATTTACTTCTGT	0.403													2	4	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15197155	15197156	+	RNA	INS	-	-	T	rs114452258	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:15197155_15197156insT	ENST00000502344.1	-	0	154				RP11-665G4.1_ENST00000513384.1_RNA																							gggtcactcccgggcattaact	0.520													2	4	---	---	---	---					
RP11-3J1.1	0	broad.mit.edu	37	4	19388782	19388782	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:19388782delA	ENST00000505347.1	-	0	349																											TGAATGAGATAAAAAAAGTAA	0.353													2	4	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19551090	19551091	+	RNA	INS	-	-	T	rs146093698	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:19551090_19551091insT	ENST00000511431.1	+	0	288																											catcatcatgattttttttagc	0.347													2	4	---	---	---	---					
RP11-25H12.1	0	broad.mit.edu	37	4	66935398	66935399	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:66935398_66935399insA	ENST00000508572.1	+	0	463																											agactttaagcaaaaaactgta	0.307													2	4	---	---	---	---					
LINC01088	100505875	broad.mit.edu	37	4	79911279	79911280	+	RNA	DEL	TG	TG	-	rs66970699		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:79911279_79911280delTG	ENST00000509088.1	+	0	182				RP11-438E5.1_ENST00000510667.1_RNA	NR_038342.1																						tgcgtgtgtttgtgtgtgtgtg	0.569													3	3	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82741045	82741046	+	RNA	DEL	AA	AA	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:82741045_82741046delAA	ENST00000510780.1	-	0	390																											ACTTCCCTGCAAAAAAAAAAAA	0.312													3	3	---	---	---	---					
LOC100507053	100507053	broad.mit.edu	37	4	100094283	100094284	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:100094283_100094284insT	ENST00000500358.2	+	0	3714				RP11-696N14.1_ENST00000506454.1_RNA|RP11-696N14.1_ENST00000506160.1_RNA	NR_037884.1																						ttctatttaccagtattttatt	0.351													6	3	---	---	---	---					
LINC01378	103689918	broad.mit.edu	37	4	118537600	118537600	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:118537600delA	ENST00000422145.3	+	0	159																											acatgcatgcatatgttcatt	0.303													3	3	---	---	---	---					
RP11-679C8.2	0	broad.mit.edu	37	4	121276848	121276849	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:121276848_121276849insA	ENST00000508362.1	+	0	286				RP11-679C8.2_ENST00000504106.1_RNA																							TTCAAGAGTGCAAAAAGCATTA	0.356													2	4	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128068853	128068853	+	RNA	DEL	T	T	-	rs139503329		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:128068853delT	ENST00000504050.1	-	0	483																											tccttttttcttttttttttt	0.453													3	4	---	---	---	---					
CTD-2012I17.1	0	broad.mit.edu	37	4	135704772	135704773	+	RNA	INS	-	-	AT			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:135704772_135704773insAT	ENST00000504882.1	+	0	231																											gttcatcagggatattggcctg	0.391													2	4	---	---	---	---					
DCHS2	54798	broad.mit.edu	37	4	155244402	155244405	+	Frame_Shift_Del	DEL	TTTG	TTTG	-	rs112727159		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:155244402_155244405delTTTG	ENST00000339452.1	-	8	4455_4458	c.4095_4098delCAAA	c.(4093-4098)aafs	p.NK1365fs	DCHS2_ENST00000357232.3_Intron	NM_001142552.1	NP_001136024.1	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1234	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		aggtCAGGATtttgtttgtttgtt	0.377													5	1	---	---	---	---					
RP11-217C7.1	0	broad.mit.edu	37	4	167434110	167434110	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:167434110delA	ENST00000514134.1	-	0	152																											gacatttttcaaaagaagaca	0.318													6	1	---	---	---	---					
RP11-310I9.1	0	broad.mit.edu	37	4	168966707	168966708	+	RNA	DEL	CA	CA	-	rs111499593		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr4:168966707_168966708delCA	ENST00000506926.1	-	0	103																											CCTTGTGCCTcacacacacaca	0.406													3	4	---	---	---	---					
RP11-445O3.2	0	broad.mit.edu	37	5	4650512	4650512	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:4650512delA	ENST00000507435.1	-	0	429																											ATGATAAAGGAAAAACATCTA	0.398													2	4	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	6971637	6971638	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:6971637_6971638insG	ENST00000512838.1	+	0	69																											gagtggggggaggggggaagga	0.490													2	4	---	---	---	---					
LOC100653061	100653061	broad.mit.edu	37	5	34181239	34181240	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:34181239_34181240insC	ENST00000514048.1	-	0	231																											TTTTACATCTTCCCCCCACCAT	0.525													2	4	---	---	---	---					
CTD-2116N24.1	0	broad.mit.edu	37	5	38124112	38124113	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:38124112_38124113insC	ENST00000513039.2	+	0	233																											gcagggtacagcccccctcctg	0.535													2	4	---	---	---	---					
CTC-340D7.1	0	broad.mit.edu	37	5	68178870	68178871	+	RNA	INS	-	-	T	rs66795123	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:68178870_68178871insT	ENST00000503268.1	-	0	377																		p.0?(1)									aaaaaaaaggctagacgaggtg	0.525													2	4	---	---	---	---					
CTC-340D7.1	0	broad.mit.edu	37	5	68251607	68251608	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:68251607_68251608insA	ENST00000503268.1	-	0	377																		p.0?(1)									TAGATTAGTGGAAAAAAGTCCT	0.426													2	4	---	---	---	---					
RP11-72L22.1	0	broad.mit.edu	37	5	86422973	86422973	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:86422973delG	ENST00000503349.1	+	0	343																											AGTGAGCTCAGGAAGGAAGTA	0.478													2	4	---	---	---	---					
CTC-498M16.4	0	broad.mit.edu	37	5	87748856	87748859	+	RNA	DEL	TAGT	TAGT	-	rs35350050		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:87748856_87748859delTAGT	ENST00000504034.2	-	0	25																											gatctcctggtagttagtttctgt	0.480													2	4	---	---	---	---					
MEF2C-AS1	101929423	broad.mit.edu	37	5	88595381	88595388	+	RNA	DEL	ACACACAC	ACACACAC	-	rs55923004		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:88595381_88595388delACACACAC	ENST00000512585.1	+	0	319				MEF2C-AS1_ENST00000514092.1_RNA																							agtattctaaacacacacacacacacac	0.332													3	4	---	---	---	---					
RP11-6N13.1	0	broad.mit.edu	37	5	103931870	103931871	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:103931870_103931871insC	ENST00000503650.1	-	0	328																											tacctcaaattcccccccacac	0.465													3	5	---	---	---	---					
RP11-6N13.1	0	broad.mit.edu	37	5	104671817	104671818	+	RNA	INS	-	-	A	rs58095692		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:104671817_104671818insA	ENST00000503650.1	-	0	210																											atagctattacaaaaaaaaaaa	0.327													4	4	---	---	---	---					
APC	324	broad.mit.edu	37	5	112175753	112175771	+	Frame_Shift_Del	DEL	TTATTACATTTTGCCACGG	TTATTACATTTTGCCACGG	-	rs41115	byFrequency	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:112175753_112175771delTTATTACATTTTGCCACGG	ENST00000457016.1	+	16	4842_4860	c.4462_4480delTTATTACATTTTGCCACGG	c.(4462-4482)aafs	p.LLHFATE1488fs	APC_ENST00000257430.4_Frame_Shift_Del_p.LLHFATE1488fs|APC_ENST00000508376.2_Frame_Shift_Del_p.LLHFATE1488fs|CTC-554D6.1_ENST00000520401.1_Intron			P25054	APC_HUMAN	adenomatous polyposis coli	1488	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.F1491fs*16(23)|p.T1493fs*14(21)|p.L1488fs*18(18)|p.L1488fs*19(13)|p.T1487fs*17(10)|p.E1494fs*13(9)|p.H1490fs*17(4)|p.L1488fs*26(4)|p.L1489fs*19(4)|p.A1492fs*22(4)|p.L1488*(3)|p.L1488fs*23(3)|p.A1492fs*15(3)|p.H1490fs*23(3)|p.L1489fs*18(3)|p.E1494fs*19(3)|p.H1490fs*15(2)|p.L1488fs*20(2)|p.L1488fs*25(2)|p.H1490fs*24(2)|p.T1493fs*21(2)|p.K1454fs*3(1)|p.T1493fs*13(1)|p.L1489fs*23(1)|p.T1487fs*25(1)|p.T1493fs*17(1)|p.L1488fs*22(1)|p.T1487fs*23(1)|p.L1489V(1)|p.S1495fs*19(1)|p.?(1)|p.L1488F(1)|p.H1490Y(1)|p.K1192fs*3(1)|p.L1489*(1)|p.?fs(1)|p.L1488fs*13(1)|p.F1491fs*17(1)|p.E1494*(1)|p.E1494fs*12(1)|p.E1494fs*11(1)|p.F1491L(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGCTGATACTTTATTACATTTTGCCACGGAAAGTACTCC	0.434		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			7	44	---	---	---	---					
RP11-508M8.1	0	broad.mit.edu	37	5	124468216	124468217	+	RNA	DEL	CA	CA	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:124468216_124468217delCA	ENST00000512965.1	+	0	49																											gattcatacccacccgcattag	0.431													2	4	---	---	---	---					
LOC101927460	101927460	broad.mit.edu	37	5	124865529	124865529	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:124865529delA	ENST00000564199.1	+	0	324																											TTTGGAGACCAAAAATATGAT	0.348													2	4	---	---	---	---					
CTC-575N7.1	0	broad.mit.edu	37	5	129198233	129198233	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:129198233delA	ENST00000503616.1	-	0	121				CTC-575N7.1_ENST00000515569.1_RNA																							accctgtctcaaaaaaaaaaa	0.403													2	4	---	---	---	---					
RP11-541P9.3	0	broad.mit.edu	37	5	162677017	162677018	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:162677017_162677018insT	ENST00000509211.1	-	0	117				RP11-541P9.3_ENST00000458002.2_RNA																							taatggctaaatttttttaaaa	0.347													2	4	---	---	---	---					
CTC-207P7.1	0	broad.mit.edu	37	5	163556896	163556897	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr5:163556896_163556897insT	ENST00000521805.1	-	0	495																											ttgcttgctccttttgttcagg	0.480													2	4	---	---	---	---					
RP1-167F1.2	0	broad.mit.edu	37	6	19631434	19631435	+	RNA	INS	-	-	TG	rs5874721	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr6:19631434_19631435insTG	ENST00000432171.2	-	0	366																											TGTTTAAAATCtgtgtgtgtgt	0.391													4	3	---	---	---	---					
HCG17	414778	broad.mit.edu	37	6	30227536	30227537	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr6:30227536_30227537insG	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							ccgcccggcccggggagccgcg	0.733													4	2	---	---	---	---					
RP1-179N16.6	0	broad.mit.edu	37	6	36147689	36147689	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr6:36147689delA	ENST00000499560.2	-	0	265				RP1-179N16.6_ENST00000526611.1_RNA																							atcagagatgaaaaaaaaagt	0.343													2	4	---	---	---	---					
LOC101927640	101927640	broad.mit.edu	37	6	112629375	112629376	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr6:112629375_112629376insC	ENST00000587816.1	+	0	111				RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000590673.1_RNA																							ATTTCTCACTGCCCCCCCTTCC	0.535													2	4	---	---	---	---					
TARID	100507308	broad.mit.edu	37	6	133956549	133956550	+	RNA	INS	-	-	C	rs151277487	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr6:133956549_133956550insC	ENST00000607033.1	-	0	623				RP3-323P13.2_ENST00000607573.1_RNA|RP3-323P13.2_ENST00000606292.1_RNA|RP3-323P13.2_ENST00000606544.1_RNA																							GATTTGAGATAGTCTAAGAGGG	0.411													5	2	---	---	---	---					
LOC102724087	102724087	broad.mit.edu	37	6	161355020	161355020	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr6:161355020delT	ENST00000417479.1	+	0	293																											ATCCAACCTGTTTTGGAACAT	0.343													2	4	---	---	---	---					
LINC01162	104355138	broad.mit.edu	37	7	20959748	20959749	+	RNA	INS	-	-	T	rs35951194		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:20959748_20959749insT	ENST00000447262.2	+	0	151																											TGGGTGTCTCCTTTTTTTTTTT	0.416													4	3	---	---	---	---					
FAM126A	84668	broad.mit.edu	37	7	22971313	22971314	+	RNA	INS	-	-	T	rs59246635	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:22971313_22971314insT	ENST00000421730.1	-	0	137																											tagactgatggtaaaaatgtga	0.361													3	4	---	---	---	---					
AC006380.3	0	broad.mit.edu	37	7	31456564	31456565	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:31456564_31456565insA	ENST00000433356.1	-	0	38																											ATTTCAGCAAGAAAAAAAAAAG	0.386													2	4	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34530445	34530447	+	RNA	DEL	AAT	AAT	-	rs10564848		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:34530445_34530447delAAT	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						gaagatgcacaataataaaatag	0.443													3	5	---	---	---	---					
RP11-3P22.2	0	broad.mit.edu	37	7	68733535	68733539	+	RNA	DEL	TTTTG	TTTTG	-	rs71737055		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:68733535_68733539delTTTTG	ENST00000435148.1	-	0	590																											CTATGTGTGTttttgttttgttttg	0.512													3	5	---	---	---	---					
AC003988.1	0	broad.mit.edu	37	7	79897446	79897447	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:79897446_79897447insT	ENST00000447198.2	-	0	202																											TAAGTATTTCGTTTTTTGTAAA	0.302													2	4	---	---	---	---					
STEAP2-AS1	100874100	broad.mit.edu	37	7	89778186	89778187	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:89778186_89778187insG	ENST00000478318.2	-	0	424																											GTTCAGCATTTGGGGGGTGCCA	0.455													2	4	---	---	---	---					
DLX6-AS1	285987	broad.mit.edu	37	7	96606809	96606810	+	RNA	INS	-	-	CA	rs34992864	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:96606809_96606810insCA	ENST00000430027.2	-	0	1386				DLX6-AS1_ENST00000431497.2_RNA|DLX6-AS1_ENST00000430404.2_RNA|DLX6-AS1_ENST00000437331.2_RNA|DLX6-AS1_ENST00000452769.2_RNA|DLX6-AS1_ENST00000605417.1_RNA	NR_015448.1																						TTTGCCACTTTCACacacacac	0.376													2	4	---	---	---	---					
AC004014.3	0	broad.mit.edu	37	7	108583007	108583008	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:108583007_108583008insG	ENST00000413406.1	+	0	75																											cgccactactagggggtgcctc	0.550													2	4	---	---	---	---					
RP11-328J2.1	0	broad.mit.edu	37	7	119469615	119469616	+	RNA	DEL	GT	GT	-	rs10538380		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:119469615_119469616delGT	ENST00000426413.1	-	0	83																											attcccccacgtgtgtgtgtgt	0.351													4	8	---	---	---	---					
AC016831.7	0	broad.mit.edu	37	7	130560620	130560620	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:130560620delA	ENST00000447430.1	+	0	156																											gcagccgtacaagcatggcac	0.483													2	4	---	---	---	---					
AC009784.3	0	broad.mit.edu	37	7	135828743	135828743	+	RNA	DEL	T	T	-	rs112107338		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr7:135828743delT	ENST00000445293.2	+	0	230																											agaatccaagttttttttttt	0.343													2	4	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36465021	36465022	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:36465021_36465022insA	ENST00000524132.1	-	0	484																											cccacaactccaaaaacattct	0.396													2	4	---	---	---	---					
RP11-346L1.2	0	broad.mit.edu	37	8	37513298	37513299	+	RNA	DEL	GT	GT	-	rs35865529		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:37513298_37513299delGT	ENST00000519978.1	-	0	426																											gcgcatgtgcgtgtgtgtgtgt	0.450													2	4	---	---	---	---					
LOC101929268	101929268	broad.mit.edu	37	8	49539092	49539093	+	RNA	DEL	GA	GA	-	rs35440877		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:49539092_49539093delGA	ENST00000522575.1	+	0	356																											gtgtgtgtgtgAGAGAGAGAGA	0.545													4	5	---	---	---	---					
RP11-120I21.2	0	broad.mit.edu	37	8	85032797	85032798	+	RNA	INS	-	-	T	rs75212095	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:85032797_85032798insT	ENST00000523678.1	+	0	279																											CTCTCTTCCCATTTTTTTTTTT	0.386													5	4	---	---	---	---					
RP11-386D6.2	0	broad.mit.edu	37	8	87806190	87806190	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:87806190delA	ENST00000520649.1	+	0	449																											TTTCCCTTGGAAAAAAAAAAA	0.403													4	2	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89434738	89434739	+	RNA	DEL	AA	AA	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:89434738_89434739delAA	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							acacacacacaAAAACAAAACC	0.327													2	4	---	---	---	---					
C8orf37-AS1	100616530	broad.mit.edu	37	8	96659579	96659580	+	RNA	DEL	AC	AC	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:96659579_96659580delAC	ENST00000521905.1	+	0	320																											gatgttacaaacacacacacac	0.371													2	4	---	---	---	---					
RP11-238I10.1	0	broad.mit.edu	37	8	111630555	111630555	+	RNA	DEL	C	C	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:111630555delC	ENST00000523264.1	+	0	66																											ccctcctcctcccccactcct	0.517													5	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117070191	117070192	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:117070191_117070192insG	ENST00000505156.2	-	0	1558					NR_046215.1																						cttgtgataatgggggggtcta	0.426													2	4	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117231464	117231464	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:117231464delA	ENST00000505156.2	-	0	1333					NR_046215.1																						TAATATTTGTAAAAAAAACTT	0.318													2	4	---	---	---	---					
CASC8	727677	broad.mit.edu	37	8	128401979	128401980	+	RNA	INS	-	-	T	rs142175522	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:128401979_128401980insT	ENST00000502082.1	-	0	1176				CASC8_ENST00000523825.1_RNA|CASC8_ENST00000501396.1_RNA|RP11-382A18.2_ENST00000521586.1_lincRNA																							CTGCATATATGtttttttttta	0.411													4	6	---	---	---	---					
CCDC26	137196	broad.mit.edu	37	8	130558287	130558288	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:130558287_130558288insG	ENST00000446592.3	-	0	312																											AATGAATGGTTGGGGGGGTGAG	0.455													2	4	---	---	---	---					
CTD-2534J5.1	0	broad.mit.edu	37	8	140133448	140133448	+	RNA	DEL	T	T	-	rs34333333		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:140133448delT	ENST00000517640.1	-	0	228																											GAATAATGGGTTTGGGCTATT	0.363													2	4	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142517130	142517131	+	RNA	INS	-	-	G	rs11464845	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr8:142517130_142517131insG	ENST00000430863.1	-	0	161					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TGAGTACCGGTGGGGGGGGGTC	0.668													4	3	---	---	---	---					
CDKN2B-AS1	100048912	broad.mit.edu	37	9	22119511	22119512	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr9:22119511_22119512insA	ENST00000428597.1	+	0	3032				CDKN2B-AS1_ENST00000582072.1_RNA|CDKN2B-AS1_ENST00000422420.1_RNA|CDKN2B-AS1_ENST00000580576.1_RNA|CDKN2B-AS1_ENST00000577551.1_RNA|CDKN2B-AS1_ENST00000584020.1_RNA|CDKN2B-AS1_ENST00000581051.1_RNA|CDKN2B-AS1_ENST00000584816.1_RNA|CDKN2B-AS1_ENST00000585267.1_RNA|CDKN2B-AS1_ENST00000584637.1_RNA	NR_003529.3																						GAACAAGGAAGAAAAAAAGGGT	0.386													2	4	---	---	---	---					
LOC101928438	101928438	broad.mit.edu	37	9	102478225	102478226	+	RNA	INS	-	-	TCTC	rs113492451	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr9:102478225_102478226insTCTC	ENST00000427039.1	-	0	319																											ccttttgcctgtctctctctct	0.490													3	3	---	---	---	---					
RP11-202G18.1	0	broad.mit.edu	37	9	113966734	113966735	+	RNA	DEL	AC	AC	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr9:113966734_113966735delAC	ENST00000426204.1	-	0	370																											gttggagaggacacacacacac	0.376													3	5	---	---	---	---					
LINC00474	58483	broad.mit.edu	37	9	118675038	118675039	+	RNA	DEL	TT	TT	-	rs34311686		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr9:118675038_118675039delTT	ENST00000374014.3	-	0	185					NR_024032.1																						AACTTCAAGCTTTTTTTTTTTT	0.361													2	4	---	---	---	---					
AKR1C7P	648947	broad.mit.edu	37	10	5327729	5327730	+	RNA	INS	-	-	CTAA	rs146676349	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:5327729_5327730insCTAA	ENST00000432689.2	-	0	81																											AATACATTGTTCTGAGACCACA	0.361													4	4	---	---	---	---					
CCNYL2	414194	broad.mit.edu	37	10	42940911	42940911	+	RNA	DEL	A	A	-	rs56213924		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:42940911delA	ENST00000483242.3	-	0	698					NR_103829.1				cyclin Y-like 2											breast(2)|endometrium(1)|lung(3)|ovary(1)	7						gcttcaggctaaaaaaaaaaa	0.393													4	2	---	---	---	---					
RP11-445N18.7	0	broad.mit.edu	37	10	45652086	45652087	+	RNA	INS	-	-	A	rs77869897		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:45652086_45652087insA	ENST00000427229.2	+	0	1739																											agactcagtctaaaaaaaaaaa	0.431													2	4	---	---	---	---					
RBM20	282996	broad.mit.edu	37	10	112581637	112581638	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:112581637_112581638insC	ENST00000369519.3	+	11	3318_3319	c.3260_3261insC	c.(3259-3261)accfs	p.T1087fs		NM_001134363.1	NP_001127835.1	Q5T481	RBM20_HUMAN	RNA binding motif protein 20	1087						nucleus	nucleotide binding|RNA binding|zinc ion binding	p.I1090fs*4(1)		autonomic_ganglia(1)|endometrium(4)|kidney(3)|large_intestine(1)|ovary(1)|skin(2)	12						GAGAAAGCCAGCCCCCCCATCG	0.594													3	3	---	---	---	---					
RP11-95I16.2	0	broad.mit.edu	37	10	122739662	122739663	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:122739662_122739663insG	ENST00000414774.1	-	0	49																											GCTCAGCCCTTGGGGGCTGAGG	0.639													2	4	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125175267	125175267	+	RNA	DEL	A	A	-	rs35273863		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr10:125175267delA	ENST00000448347.1	+	0	586																											AGTGGTTCACAAAAAAAGTCA	0.323													7	1	---	---	---	---					
RP11-98J9.2	0	broad.mit.edu	37	11	13875228	13875228	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:13875228delG	ENST00000530492.1	-	0	78				RP11-98J9.3_ENST00000525381.1_lincRNA																							atgtgcagctggaaaccctcc	0.517													2	4	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14122320	14122320	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:14122320delT	ENST00000310358.7	+	0	1211							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		TACAAGAGTATTTTTATAATA	0.318													2	4	---	---	---	---					
RP11-945A11.2	0	broad.mit.edu	37	11	23824680	23824680	+	RNA	DEL	T	T	-	rs113329759		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:23824680delT	ENST00000525512.1	-	0	120																											tatgtATATAttttttttttt	0.453													2	4	---	---	---	---					
BDNF-AS	497258	broad.mit.edu	37	11	27630850	27630851	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:27630850_27630851insG	ENST00000499008.3	+	0	213				BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000532965.1_RNA|BDNF-AS_ENST00000502161.2_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000501176.2_RNA	NR_002832.2																						GAAATCAAATAGGGGGGCATAC	0.322													2	4	---	---	---	---					
CTD-3138F19.1	0	broad.mit.edu	37	11	29859967	29859968	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:29859967_29859968insT	ENST00000530249.1	+	0	343																											AAAATATTGCCTTTTCCACAAA	0.312													2	4	---	---	---	---					
RP11-148I19.1	0	broad.mit.edu	37	11	42127387	42127388	+	RNA	INS	-	-	A	rs111985430		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:42127387_42127388insA	ENST00000534059.1	-	0	220																											ccatctccaataaaaaaaaaaa	0.386													3	3	---	---	---	---					
RP11-430H10.4	0	broad.mit.edu	37	11	45518473	45518473	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:45518473delA	ENST00000528445.1	-	0	530				RP11-958J22.1_ENST00000533315.1_RNA																							gtaataccctaaaaaaaattc	0.313													2	4	---	---	---	---					
RP11-626H12.2	0	broad.mit.edu	37	11	69863382	69863383	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:69863382_69863383insA	ENST00000528507.1	-	0	301																											AACGGAACTGCAAAAAGTCTAC	0.396													2	4	---	---	---	---					
LOC102723895	102723895	broad.mit.edu	37	11	104461239	104461243	+	RNA	DEL	GGTAT	GGTAT	-	rs61191456		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr11:104461239_104461243delGGTAT	ENST00000536529.1	-	0	60																											ctagccaatgggtatggtatgcttc	0.424													6	4	---	---	---	---					
RP11-606D9.1	0	broad.mit.edu	37	12	17751478	17751479	+	RNA	INS	-	-	ACAC	rs61454840		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:17751478_17751479insACAC	ENST00000539105.1	+	0	127																											tgtatgtgtatacacacacaca	0.317													2	4	---	---	---	---					
RP11-606D9.1	0	broad.mit.edu	37	12	17752946	17752949	+	RNA	DEL	TGTA	TGTA	-	rs113134577		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:17752946_17752949delTGTA	ENST00000539105.1	+	0	127																											tctatacctttgtatgtatgtatg	0.377													3	4	---	---	---	---					
RP11-168J19.2	0	broad.mit.edu	37	12	65413112	65413112	+	RNA	DEL	T	T	-	rs143771244		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:65413112delT	ENST00000360528.2	+	0	140																											aactctctggttttttttttt	0.473													3	4	---	---	---	---					
RP11-123O10.4	0	broad.mit.edu	37	12	67401258	67401259	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:67401258_67401259insC	ENST00000535721.1	-	0	113																											ACTCCCCTCATCCCCCCCAAAA	0.361													2	4	---	---	---	---					
LINC01481	101928062	broad.mit.edu	37	12	70430783	70430786	+	RNA	DEL	ACAC	ACAC	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:70430783_70430786delACAC	ENST00000549419.1	-	0	144																											TATacacacaacacacacacacac	0.377													2	4	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76033877	76033878	+	RNA	INS	-	-	GT	rs147992363	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:76033877_76033878insGT	ENST00000552856.1	-	0	401																											ATGAGTGTATCgtgtgtgtgtg	0.332													5	3	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	76371418	76371418	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:76371418delT	ENST00000552856.1	-	0	295																											acacacGTAATTTtttttttt	0.403													3	4	---	---	---	---					
RP11-511B23.2	0	broad.mit.edu	37	12	93576745	93576745	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:93576745delT	ENST00000547432.1	-	0	316				RP11-511B23.2_ENST00000549930.1_RNA																							tctttttttcttttttttttt	0.448													2	4	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97405656	97405657	+	RNA	INS	-	-	ACAC			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:97405656_97405657insACAC	ENST00000552238.1	+	0	39																											TAGTCATGTAAacacacacaca	0.366													2	4	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97444799	97444799	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:97444799delT	ENST00000552238.1	+	0	39				RP11-397H6.1_ENST00000549896.1_lincRNA																							TCCTTTTTTATTATCTTTTGG	0.289													2	4	---	---	---	---					
RP11-897M7.1	0	broad.mit.edu	37	12	131967722	131967722	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr12:131967722delA	ENST00000535133.1	-	0	195																											tgcctgcctgAAGCAGGGTGA	0.512													2	4	---	---	---	---					
RP11-266E6.3	0	broad.mit.edu	37	13	35232146	35232147	+	RNA	INS	-	-	A	rs67218311		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:35232146_35232147insA	ENST00000606365.1	-	0	183																											TCTGTGTGGGGAAAAAAAAAAA	0.396													2	4	---	---	---	---					
GUCY1B2	2974	broad.mit.edu	37	13	51591405	51591406	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:51591405_51591406insG	ENST00000493639.2	-	0	1433					NR_003923.2																						atcatatcacagggggcaagca	0.520													2	4	---	---	---	---					
ATXN8OS	6315	broad.mit.edu	37	13	70683846	70683847	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:70683846_70683847insA	ENST00000424524.1	+	0	108				ATXN8OS_ENST00000414504.2_RNA																							GTTTATTAAGCAAAAAACCCTT	0.322													2	4	---	---	---	---					
NALCN-AS1	100885778	broad.mit.edu	37	13	101609047	101609048	+	RNA	DEL	TG	TG	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:101609047_101609048delTG	ENST00000457843.1	+	0	141					NR_047687.1																						CATACACACTTGTGTGTGTGTG	0.416													2	4	---	---	---	---					
RP11-54H7.2	0	broad.mit.edu	37	13	109939689	109939689	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr13:109939689delT	ENST00000455487.1	+	0	306																											TATCTCCCAGTTTTATGTGGT	0.383													2	4	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	27796210	27796210	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:27796210delT	ENST00000553392.1	-	0	262																											agctcatagattttgccttca	0.348													2	4	---	---	---	---					
AL162759.1	0	broad.mit.edu	37	14	54258662	54258663	+	RNA	INS	-	-	ATT			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:54258662_54258663insATT	ENST00000418927.1	-	0	580																											GTGAGGGAACAATTATAACTCC	0.342													2	4	---	---	---	---					
RP11-526N18.1	0	broad.mit.edu	37	14	80360026	80360027	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:80360026_80360027insC	ENST00000554307.1	-	0	366																											tcctgcctcaaccccccaagta	0.550													2	4	---	---	---	---					
DIO2-AS1	100628307	broad.mit.edu	37	14	80716738	80716739	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:80716738_80716739insT	ENST00000553979.1	+	0	178					NR_038355.1																						tcgttttattcttttttctcta	0.401													2	4	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82309211	82309212	+	RNA	DEL	GT	GT	-	rs10543551		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:82309211_82309212delGT	ENST00000554814.1	+	0	315																											gtgtgcgtgcgtgtgtgtgtgt	0.455													3	3	---	---	---	---					
LOC101928767	101928767	broad.mit.edu	37	14	86538174	86538175	+	RNA	INS	-	-	AGAG			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:86538174_86538175insAGAG	ENST00000553668.1	+	0	182																											gagagagagaaagagagaaaga	0.446													3	4	---	---	---	---					
RP11-736P16.1	0	broad.mit.edu	37	14	87448894	87448895	+	RNA	DEL	CT	CT	-	rs35341170		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr14:87448894_87448895delCT	ENST00000554181.1	+	0	188																											aatctctccactctctctctct	0.421													5	5	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20600895	20600895	+	RNA	DEL	T	T	-	rs61665666		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:20600895delT	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TTCCCTACTATTAGCTATAAT	0.333													5	11	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20616749	20616750	+	RNA	INS	-	-	TT	rs4491484		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:20616749_20616750insTT	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TAATCCTTTCGtttttttttta	0.327													2	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22305874	22305875	+	RNA	DEL	CT	CT	-	rs145001744		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:22305874_22305875delCT	ENST00000558896.1	+	0	99																											aatcgcccccctgatattgCAG	0.386													3	5	---	---	---	---					
SNHG14	104472715	broad.mit.edu	37	15	25552240	25552241	+	RNA	DEL	TT	TT	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:25552240_25552241delTT	ENST00000554726.1	+	0	245				SNHG14_ENST00000452731.1_RNA																							cctagattcatttttttTTTTT	0.307													4	7	---	---	---	---					
RP11-624L4.1	0	broad.mit.edu	37	15	39266615	39266615	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:39266615delT	ENST00000560197.1	-	0	170				RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA																							AATTCGCCTCTACTTTAGAAA	0.343													3	4	---	---	---	---					
DUOX1	53905	broad.mit.edu	37	15	45457005	45457006	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:45457005_45457006insC	ENST00000321429.4	+	35	4969_4970	c.4562_4563insC	c.(4561-4563)gccfs	p.A1521fs	DUOX1_ENST00000389037.3_Frame_Shift_Ins_p.A1521fs|CTD-2651B20.1_ENST00000558039.1_lincRNA|DUOX1_ENST00000561166.1_Frame_Shift_Ins_p.A1167fs	NM_017434.3	NP_059130.2	Q9NRD9	DUOX1_HUMAN	dual oxidase 1	1521					cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity	p.G1524fs*26(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		TTTAGCTGTGGCCCCCCTGGCA	0.545													7	281	---	---	---	---					
RP11-209E8.1	0	broad.mit.edu	37	15	53409025	53409025	+	RNA	DEL	T	T	-	rs66684830		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:53409025delT	ENST00000559915.1	+	0	94																											TTTTTTCGTGTTTTTTTTTTT	0.294													4	2	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	88164889	88164889	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:88164889delA	ENST00000560439.1	-	0	80																											acaaggatttaaaaaaaaaaa	0.348													4	3	---	---	---	---					
NTRK3-AS1	283738	broad.mit.edu	37	15	88814040	88814041	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:88814040_88814041insC	ENST00000569588.1	+	0	2406_2407					NR_038229.1																						TCCCTAACAAGCCCCCCAATTT	0.475													2	4	---	---	---	---					
LINC01579	283682	broad.mit.edu	37	15	94409710	94409713	+	RNA	DEL	ACTC	ACTC	-	rs140881721		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:94409710_94409713delACTC	ENST00000557481.2	-	0	430				RP11-76E17.3_ENST00000554530.1_lincRNA																							CACATGACTTACTCACCTAAGCTT	0.426													2	4	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94627513	94627516	+	RNA	DEL	GTGT	GTGT	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr15:94627513_94627516delGTGT	ENST00000558874.1	-	0	60																											TGCTGGGCACgtgtgtgtgtgtgt	0.480													3	3	---	---	---	---					
FBRS	64319	broad.mit.edu	37	16	30681558	30681559	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:30681558_30681559insG	ENST00000395073.2	+	13	1663_1664	c.1136_1137insG	c.(1135-1137)cggfs	p.R379fs	FBRS_ENST00000287468.5_3'UTR|FBRS_ENST00000356166.6_3'UTR|FBRS_ENST00000568722.1_3'UTR			Q9HAH7	FBRS_HUMAN	fibrosin	0	Pro-rich.									ovary(1)	1			Colorectal(24;0.103)			AGGGGACTGCAGGGGGAAGAGC	0.629													2	4	---	---	---	---					
RP11-1166P10.6	0	broad.mit.edu	37	16	32031891	32031892	+	RNA	INS	-	-	G	rs138909480	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:32031891_32031892insG	ENST00000566806.1	-	0	499																											GAAAATGCCCAGGGGGGCCCAG	0.574													2	4	---	---	---	---					
RP11-410D17.2	0	broad.mit.edu	37	16	58924419	58924420	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:58924419_58924420insC	ENST00000500117.1	+	0	679																											ATAGCTTTTTTCCCCCCCAGAA	0.297													2	4	---	---	---	---					
LOC101927580	101927580	broad.mit.edu	37	16	60028598	60028598	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:60028598delA	ENST00000568279.1	+	0	173																											CTTGAGACTCAAAAAATAATA	0.274													2	4	---	---	---	---					
AC012322.1	0	broad.mit.edu	37	16	64358902	64358902	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:64358902delT	ENST00000561657.1	-	0	381																											TCTGAGACCCTTATGTTTCTG	0.358													2	4	---	---	---	---					
RP11-256I9.3	0	broad.mit.edu	37	16	65317699	65317700	+	RNA	DEL	CA	CA	-	rs71814385		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:65317699_65317700delCA	ENST00000562656.1	+	0	271																											ctctctctctcacacacacaca	0.470													6	5	---	---	---	---					
RP11-525K10.1	0	broad.mit.edu	37	16	80141621	80141628	+	RNA	DEL	ACACACAC	ACACACAC	-	rs56852502		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:80141621_80141628delACACACAC	ENST00000567851.1	+	0	405																											agtgctctcaacacacacacacacacac	0.327													3	4	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80339073	80339074	+	RNA	INS	-	-	T	rs72528126	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:80339073_80339074insT	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568776.1_RNA|RP11-525K10.3_ENST00000568819.1_RNA																							GCACGTGGATATTTTTTGTGCT	0.302													2	4	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80466949	80466949	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr16:80466949delA	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568776.1_RNA|RP11-525K10.3_ENST00000568819.1_RNA																							TGTCAGGAGCAAAACAAGACC	0.378													2	4	---	---	---	---					
RP11-64J4.2	0	broad.mit.edu	37	17	3199096	3199097	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:3199096_3199097insA	ENST00000573491.1	-	0	359																											tgtttgaattcaaaaaagtcag	0.317													2	4	---	---	---	---					
AC022816.2	0	broad.mit.edu	37	17	14279099	14279100	+	RNA	INS	-	-	T	rs71361435		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:14279099_14279100insT	ENST00000436469.1	+	0	90																											tgcccggctaattttttttttt	0.535													4	1	---	---	---	---					
LOC101927239	101927239	broad.mit.edu	37	17	32505153	32505156	+	RNA	DEL	AAAC	AAAC	-	rs113433713		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:32505153_32505156delAAAC	ENST00000579438.1	+	0	1597_1600				RP11-215E13.1_ENST00000566930.2_lincRNA																							CAACATGGTaaaacaaacaaataa	0.436													4	4	---	---	---	---					
RP11-1094H24.3	0	broad.mit.edu	37	17	48087005	48087006	+	RNA	INS	-	-	C	rs79709032		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:48087005_48087006insC	ENST00000511867.1	+	0	139																											tttttttttttccccaagatgg	0.495													3	3	---	---	---	---					
RP11-429O1.1	0	broad.mit.edu	37	17	50579720	50579720	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:50579720delG	ENST00000572848.1	+	0	76																											GTGGTGATCTGGGGAAACATT	0.333													2	4	---	---	---	---					
SOX9-AS1	400618	broad.mit.edu	37	17	70037144	70037145	+	RNA	INS	-	-	T	rs138991996	by1000genomes	TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr17:70037144_70037145insT	ENST00000540802.1	-	0	272																											TGCTTTACGTGTTTTGATGCCA	0.381													2	4	---	---	---	---					
RP11-595B24.1	0	broad.mit.edu	37	18	19563386	19563387	+	RNA	INS	-	-	T			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr18:19563386_19563387insT	ENST00000584898.1	+	0	39																											gcaatggttggtttttaaaaag	0.327													2	4	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22320481	22320482	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr18:22320481_22320482insC	ENST00000582650.1	+	0	235																											aataaagatttccccccacccc	0.381													2	4	---	---	---	---					
GAREM	64762	broad.mit.edu	37	18	29827188	29827189	+	RNA	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr18:29827188_29827189insC	ENST00000581134.1	-	0	277																											tttatccctcaccccctcccac	0.421													2	4	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	36916248	36916249	+	RNA	INS	-	-	A			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr18:36916248_36916249insA	ENST00000591629.1	-	0	440					NR_024391.1																						GAGAACAGGTGAAAAAGAGACT	0.416													2	4	---	---	---	---					
LINC01538	400654	broad.mit.edu	37	18	61913869	61913869	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr18:61913869delG	ENST00000588074.1	-	0	443				RP11-146N18.1_ENST00000589376.1_lincRNA	NR_033983.1																						ATTGCATAAAGGGGTTTGTCC	0.348													3	3	---	---	---	---					
KEAP1	9817	broad.mit.edu	37	19	10600356	10600356	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:10600356delA	ENST00000171111.5	-	4	2046	c.1499delT	c.(1498-1500)acfs	p.I500fs	KEAP1_ENST00000393623.2_Frame_Shift_Del_p.I500fs	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	500					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CATTGCTGTGATCATTCGCCA	0.582													6	10	---	---	---	---					
AC005780.1	0	broad.mit.edu	37	19	28856094	28856094	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:28856094delA	ENST00000592311.1	-	0	250																											actctgtctcaaaaaaacaaa	0.443													2	4	---	---	---	---					
LOC284395	284395	broad.mit.edu	37	19	29808941	29808942	+	RNA	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:29808941_29808942insG	ENST00000582581.1	-	0	2030					NR_040029.1																						GTGTTCATGTTGGGGGCTCTCA	0.495													2	4	---	---	---	---					
CTC-439O9.3	0	broad.mit.edu	37	19	31691913	31691913	+	RNA	DEL	A	A	-	rs78817086		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:31691913delA	ENST00000589511.1	+	0	337																											gtgtcaggggaaaaaaatgta	0.308													5	1	---	---	---	---					
AC007796.1	0	broad.mit.edu	37	19	31908649	31908649	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:31908649delA	ENST00000585336.1	+	0	509																											GCCTGAAGAGAACAGGTTGCA	0.532													2	4	---	---	---	---					
MEGF8	1954	broad.mit.edu	37	19	42857115	42857116	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:42857115_42857116insC	ENST00000334370.4	+	19	3820_3821	c.3185_3186insC	c.(3184-3186)gccfs	p.A1062fs	MEGF8_ENST00000251268.6_Frame_Shift_Ins_p.A1129fs	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1129						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GTGTGCAGTGGCCCCCCGGACT	0.693													2	4	---	---	---	---					
LIPE-AS1	100996307	broad.mit.edu	37	19	43125330	43125331	+	RNA	DEL	TG	TG	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:43125330_43125331delTG	ENST00000594688.1	+	0	1450				LIPE-AS1_ENST00000594624.2_RNA	NR_073179.1																						CGTATATATAtgtgtgtgtgtg	0.371													4	2	---	---	---	---					
HSPBP1	23640	broad.mit.edu	37	19	55789106	55789107	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr19:55789106_55789107insG	ENST00000255631.5	-	4	628_629	c.318_319insC	c.(316-321)ccctgcfs	p.C107fs	HSPBP1_ENST00000587922.1_Frame_Shift_Ins_p.C107fs|HSPBP1_ENST00000433386.2_Frame_Shift_Ins_p.C107fs|HSPBP1_ENST00000376343.3_Frame_Shift_Ins_p.C107fs	NM_001130106.1|NM_012267.4	NP_001123578.1|NP_036399.3	Q9NZL4	HPBP1_HUMAN	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1	110					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		TCCCCAGCAGTGGGGGGCATGG	0.673													3	3	---	---	---	---					
KIZ-AS1	101929591	broad.mit.edu	37	20	21180957	21180957	+	RNA	DEL	T	T	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:21180957delT	ENST00000591761.1	-	0	290				PLK1S1_ENST00000457464.1_RNA|RP4-777D9.2_ENST00000443753.1_RNA|RP4-777D9.2_ENST00000433213.2_RNA																							tttaagacagtttttccatgg	0.418													2	4	---	---	---	---					
LOC284788	284788	broad.mit.edu	37	20	22399160	22399160	+	RNA	DEL	A	A	-	rs76297419		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:22399160delA	ENST00000377121.1	-	0	684					NR_027089.1																						aagtgattggaaaaaaaaaaa	0.413													2	4	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29584947	29584947	+	RNA	DEL	C	C	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:29584947delC	ENST00000432067.1	-	0	288																											gtccctgagtcccttccaggg	0.448													3	5	---	---	---	---					
LINC01271	101927586	broad.mit.edu	37	20	48936978	48936978	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr20:48936978delG	ENST00000441214.1	-	0	268																											gacagaacctggGGAGATGTA	0.473													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11071049	11071050	+	RNA	INS	-	-	G	rs3904107		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr21:11071049_11071050insG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ctctatattcagggaaaaaaag	0.361													5	11	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11087766	11087766	+	RNA	DEL	T	T	-	rs56721211		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr21:11087766delT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAGACTGTATTTTTTATGGA	0.368													3	6	---	---	---	---					
CYYR1-AS1	100996571	broad.mit.edu	37	21	27792298	27792298	+	RNA	DEL	G	G	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr21:27792298delG	ENST00000357401.3	+	0	186				AP001596.6_ENST00000429340.1_RNA|AP001597.1_ENST00000414486.1_RNA|AP001596.6_ENST00000444306.1_RNA|AP001596.6_ENST00000421771.1_RNA																							ccctagctgagggtctccata	0.522													2	4	---	---	---	---					
TPTEP1	387590	broad.mit.edu	37	22	17126069	17126069	+	RNA	DEL	A	A	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr22:17126069delA	ENST00000426585.1	+	0	442																											actccatattaaaaaaaaaaa	0.408													2	4	---	---	---	---					
PRAMENP	649179	broad.mit.edu	37	22	22379003	22379004	+	RNA	DEL	TG	TG	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr22:22379003_22379004delTG	ENST00000337471.4	-	0	1316																											gtgtgtgtgttgtgtgtgtgtg	0.366													3	6	---	---	---	---					
AP000346.2	0	broad.mit.edu	37	22	23979019	23979020	+	RNA	DEL	GA	GA	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr22:23979019_23979020delGA	ENST00000390329.2	-	0	313																											AGTTggcagggagagagagaga	0.569													2	4	---	---	---	---					
LOC284930	284930	broad.mit.edu	37	22	48049309	48049311	+	RNA	DEL	AAA	AAA	-	rs35036132		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chr22:48049309_48049311delAAA	ENST00000423737.1	+	0	387																											gatccatctcaaaaaaaaaaaaa	0.458													2	4	---	---	---	---					
GS1-600G8.5	0	broad.mit.edu	37	X	13297332	13297333	+	RNA	DEL	TG	TG	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chrX:13297332_13297333delTG	ENST00000412485.1	-	0	209																											tgtgtgtgtctgtgtgtgtgtg	0.460													2	4	---	---	---	---					
PTCHD1-AS	100873065	broad.mit.edu	37	X	22792733	22792734	+	RNA	DEL	AT	AT	-	rs113530053		TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chrX:22792733_22792734delAT	ENST00000455399.1	-	0	178																											gtgcacacacatacacacacac	0.322													2	4	---	---	---	---					
NCBP2L	392517	broad.mit.edu	37	X	107027089	107027090	+	RNA	DEL	TG	TG	-			TCGA-17-Z036-01A-01W-0746-08	TCGA-17-Z036-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	374b881a-dbe2-4b4b-bfc0-8431f1aec06c	b2be574f-5847-43c1-8599-53202a8d1387	g.chrX:107027089_107027090delTG	ENST00000509000.1	+	0	126																											ggtgtgcgtatgtgtgtgtgtg	0.421													2	4	---	---	---	---