Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL1A2	1278	broad.mit.edu	37	7	94037547	94037547	+	Splice_Site	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:94037547C>T	ENST00000297268.6	+	14	1163	c.693_splice	c.e14+1	p.A231_splice		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	231					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CCTGGCCCAGCTGTAAGTGCT	0.398000										HNSCC(75;0.22)			10	55					0	0	1	0	0
TEKT4	150483	broad.mit.edu	37	2	95541471	95541471	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:95541471G>T	ENST00000295201.4	+	5	1212	c.1075G>T	c.(1075-1077)Gac>Tac	p.D359Y	AC097374.2_ENST00000568768.1_RNA	NM_144705.2	NP_653306.1	Q8WW24	TEKT4_HUMAN	tektin 4	359					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	28						GCTGTGCCGTGACGCAGCCCA	0.632000													5	45					0.014758	0.0153781	1	1	0
SMG1	23049	broad.mit.edu	37	16	18860662	18860662	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:18860662C>T	ENST00000446231.2	-	36	5912	c.5500G>A	c.(5500-5502)Gaa>Aaa	p.E1834K	SMG1_ENST00000389467.3_Missense_Mutation_p.E1834K			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	1834	FAT.|Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ACATACACTTCAGGGTGGTTT	0.403000													5	68					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059351	9059351	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:9059351C>T	ENST00000397910.4	-	3	28298	c.28095G>A	c.(28093-28095)atG>atA	p.M9365I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9367	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGGTGATGGCCATGTCTGTTG	0.527000													18	113					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608620	4608620	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:4608620T>C	ENST00000312614.4	+	1	600	c.578T>C	c.(577-579)gTg>gCg	p.V193A		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTTGGATGGTGAGTCATCTA	0.502000													12	137					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131853231	131853231	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:131853231T>A	ENST00000359827.3	-	22	5080	c.4118A>T	c.(4117-4119)gAg>gTg	p.E1373V	PLXNA4_ENST00000321063.4_Missense_Mutation_p.E1373V			Q9HCM2	PLXA4_HUMAN	plexin A4	1373						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ACGCTGGGACTCAAGCGTGCG	0.597000													12	78					0	0	1	0	0
AGPAT6	137964	broad.mit.edu	37	8	41468329	41468329	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:41468329G>T	ENST00000396987.3	+	5	1538	c.611_splice	c.e5+1	p.R204_splice	RP11-360L9.8_ENST00000581909.1_RNA	NM_178819.3	NP_848934.1	Q86UL3	GPAT4_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 6	204					acyl-CoA metabolic process|lactation|phosphatidylcholine biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|membrane fraction	glycerol-3-phosphate O-acyltransferase activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(6)	14	Ovarian(28;0.00769)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.0131)|Lung NSC(58;0.0363)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	OV - Ovarian serous cystadenocarcinoma(14;0.00126)|Colorectal(10;0.0014)|Lung(22;0.00177)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0147)			CCAAATGGGAGGTGAGTAGAG	0.493000													14	61					4.3838e-07	5.61561e-07	1	1	0
AMN1	196394	broad.mit.edu	37	12	31842036	31842036	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:31842036T>C	ENST00000281471.6	-	6	773	c.608A>G	c.(607-609)cAt>cGt	p.H203R	AMN1_ENST00000542781.1_Missense_Mutation_p.H3R|AMN1_ENST00000541931.1_Missense_Mutation_p.H3R|AMN1_ENST00000537562.1_Missense_Mutation_p.H185R|AMN1_ENST00000536761.1_Missense_Mutation_p.H185R	NM_001113402.1|NM_001278411.1|NM_001278412.1	NP_001106873.1|NP_001265340.1|NP_001265341.1	Q8IY45	AMN1_HUMAN	antagonist of mitotic exit network 1 homolog (S. cerevisiae)	203										breast(1)|endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	7	all_cancers(9;7.41e-12)|all_epithelial(9;1.18e-11)|all_lung(12;1.14e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.162)		OV - Ovarian serous cystadenocarcinoma(6;0.0014)			ATTTACACAATGTCCCATATG	0.343000													7	33					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175688112	175688112	+	Splice_Site	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:175688112A>G	ENST00000274093.3	-	3	770		c.e3+1		GLRA3_ENST00000340217.5_Splice_Site	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3						synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	TAAAATGCCTACCATGGTCGT	0.353000													6	92					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109124652	109124652	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:109124652T>C	ENST00000261483.4	+	11	2830	c.1778T>C	c.(1777-1779)aTg>aCg	p.M593T		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	593					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		CATTCGTTAATGGTTTTGGAG	0.303000													4	57					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167248993	167248993	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:167248993C>T	ENST00000308378.3	-	9	1377	c.1072G>A	c.(1072-1074)Gga>Aga	p.G358R	WDR49_ENST00000453925.2_Missense_Mutation_p.G422R|WDR49_ENST00000476376.1_Missense_Mutation_p.G183R|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	358										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						TTGCGGACTCCCGTGGTAGAA	0.443000													10	86					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116693432	116693432	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:116693432T>A	ENST00000357780.3	-	2	233	c.119A>T	c.(118-120)aAc>aTc	p.N40I		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		CTTGGCATTGTTGCTCAGCTG	0.547000													31	174					0	0	1	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704043	52704043	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:52704043G>C	ENST00000287727.3	+	4	1126	c.954G>C	c.(952-954)ttG>ttC	p.L318F	ZFYVE9_ENST00000357206.2_Missense_Mutation_p.L318F|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.L318F|ZFYVE9_ENST00000361625.1_Missense_Mutation_p.L318F	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	318					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AGGGGATTTTGATGAAAAAAG	0.473000													5	108					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74241882	74241882	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:74241882G>A	ENST00000261921.7	+	6	2011	c.1685G>A	c.(1684-1686)cGc>cAc	p.R562H	LOXL1_ENST00000567675.1_Intron	NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	562	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						TACACAGGTCGCTACGTTTCT	0.507000													19	90					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71139753	71139753	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:71139753C>A	ENST00000283228.2	-	6	1304	c.852G>T	c.(850-852)aaG>aaT	p.K284N	PTPRR_ENST00000378778.1_Missense_Mutation_p.K78N|PTPRR_ENST00000549308.1_Missense_Mutation_p.K39N|PTPRR_ENST00000440835.2_Missense_Mutation_p.K39N|PTPRR_ENST00000342084.4_Missense_Mutation_p.K172N	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	284					in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		TGTGGACTGTCTTTGCCTCGG	0.502000													13	51					1.49906e-05	1.79424e-05	1	1	0
XDH	7498	broad.mit.edu	37	2	31565098	31565098	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:31565098C>A	ENST00000379416.3	-	32	3518	c.3470G>T	c.(3469-3471)gGg>gTg	p.G1157V		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1157					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GCAAGCCACCCCATAGCTGAA	0.443000													16	100					1.56452e-12	2.31505e-12	1	1	0
SIGLEC9	27180	broad.mit.edu	37	19	51630443	51630443	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:51630443C>T	ENST00000440804.3	+	4	972	c.905C>T	c.(904-906)cCg>cTg	p.P302L	SIGLEC9_ENST00000250360.3_Missense_Mutation_p.P302L	NM_001198558.1	NP_001185487.1	Q9Y336	SIGL9_HUMAN	sialic acid binding Ig-like lectin 9	302	Ig-like C2-type 2.				cell adhesion|cell surface receptor linked signaling pathway	integral to plasma membrane	sugar binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(3)|lung(25)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	45		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000826)|OV - Ovarian serous cystadenocarcinoma(262;0.00295)		CCCTCAAACCCGGGGGTGCTG	0.622000													9	75					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49441794	49441794	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:49441794C>T	ENST00000301067.7	-	14	4189	c.4190G>A	c.(4189-4191)tGt>tAt	p.C1397Y		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCACTGCGAACAGGCAAGGAG	0.537000													7	96					0	0	1	0	0
TAF4	6874	broad.mit.edu	37	20	60578833	60578833	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:60578833G>A	ENST00000252996.3	-	8	2324	c.2325C>T	c.(2323-2325)atC>atT	p.I775I	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	775					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TGGTGAGCATGATCCGGTTGT	0.677000													8	18					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37974962	37974962	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:37974962C>G	ENST00000330173.1	+	5	967	c.438C>G	c.(436-438)ttC>ttG	p.F146L	ZNF570_ENST00000586475.1_Missense_Mutation_p.F202L|ZNF570_ENST00000388801.3_5'UTR	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	146					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGCGTGTTTCAAGGAAGAGA	0.393000													23	200					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27239055	27239055	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:27239055G>T	ENST00000222753.4	-	1	670	c.642C>A	c.(640-642)gcC>gcA	p.A214A	HOTTIP_ENST00000421733.1_RNA	NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	214					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						CAGCTGGGCCGGCGGTATCCA	0.706000			T	NUP98	AML								6	26					2.0095e-06	2.51187e-06	1	1	0
ZC3H13	23091	broad.mit.edu	37	13	46541881	46541881	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:46541881T>C	ENST00000242848.4	-	15	4427	c.4079A>G	c.(4078-4080)gAg>gGg	p.E1360G	ZC3H13_ENST00000282007.3_Missense_Mutation_p.E1360G|ZC3H13_ENST00000378921.2_Missense_Mutation_p.E316G			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	1360							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		AATTAGtctctctctttccct	0.443000													17	45					0	0	1	0	0
CELSR2	1952	broad.mit.edu	37	1	109806903	109806903	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:109806903T>A	ENST00000271332.3	+	10	5266	c.5205T>A	c.(5203-5205)caT>caA	p.H1735Q		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1735	Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCCGGCTGCATGGTCTGCACC	0.657000											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	84					0	0	1	0	0
PUM2	23369	broad.mit.edu	37	2	20494238	20494238	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:20494238C>A	ENST00000361078.2	-	8	1073	c.1051G>T	c.(1051-1053)Ggg>Tgg	p.G351W	PUM2_ENST00000338086.5_Missense_Mutation_p.G351W|PUM2_ENST00000403432.1_Missense_Mutation_p.G351W|PUM2_ENST00000536417.1_Missense_Mutation_p.G295W|PUM2_ENST00000319801.5_Missense_Mutation_p.G351W			Q8TB72	PUM2_HUMAN	pumilio RNA-binding family member 2	351	Ala-rich.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(7)|lung(13)|ovary(2)|prostate(4)|urinary_tract(3)	42	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATACACCCCCCATGGAACG	0.507000													25	140					7.07758e-08	9.41652e-08	1	1	0
CNGA4	1262	broad.mit.edu	37	11	6261342	6261342	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:6261342G>T	ENST00000379936.2	+	4	433	c.318G>T	c.(316-318)tcG>tcT	p.S106S	CNGA4_ENST00000533426.1_Intron	NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	106					response to stimulus|sensory perception of smell		cAMP binding	p.S106S(1)		endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTAGGATCTCGAGTCGCTACG	0.602000													15	119					2.48551e-13	3.72225e-13	1	1	0
LOXL1	4016	broad.mit.edu	37	15	74241873	74241873	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:74241873A>T	ENST00000261921.7	+	6	2002	c.1676A>T	c.(1675-1677)tAc>tTc	p.Y559F	LOXL1_ENST00000567675.1_3'UTR	NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	559	Lysyl-oxidase like.				protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						AACATTCACTACACAGGTCGC	0.498000													6	116					0	0	1	0	0
ACD	65057	broad.mit.edu	37	16	67694252	67694252	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:67694252C>A	ENST00000219251.8	-	1	461	c.130G>T	c.(130-132)Ggt>Tgt	p.G44C	ACD_ENST00000393919.4_Missense_Mutation_p.G44C	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	44					intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		CCACGTACACCCCGCGCCTGC	0.736000													5	11					0.184627	0.188271	1	1	0
HMCN1	83872	broad.mit.edu	37	1	185985327	185985327	+	Missense_Mutation	SNP	G	G	T	rs146790750		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:185985327G>T	ENST00000271588.4	+	32	5376	c.5147G>T	c.(5146-5148)aGt>aTt	p.S1716I	HMCN1_ENST00000367492.2_Missense_Mutation_p.S1716I	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1716	Ig-like C2-type 14.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GTGGCTACCAGTGTGGCAGGA	0.423000													14	89					4.3838e-07	5.61561e-07	1	1	0
TRIM60	166655	broad.mit.edu	37	4	165961387	165961387	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:165961387G>T	ENST00000512596.1	+	3	379	c.163G>T	c.(163-165)Gtc>Ttc	p.V55F	TRIM60_ENST00000341062.5_Missense_Mutation_p.V55F|TRIM60_ENST00000508504.1_Missense_Mutation_p.V55F	NM_152620.2	NP_689833.1	Q495X7	TRI60_HUMAN	tripartite motif containing 60	55						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	29	all_hematologic(180;0.221)	Prostate(90;0.0959)|Melanoma(52;0.18)		GBM - Glioblastoma multiforme(119;0.0844)		TCCCTGTCCTGTCTGCCGTTT	0.483000													13	95					1.61879e-10	2.33407e-10	1	1	0
OR7A10	390892	broad.mit.edu	37	19	14952492	14952492	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:14952492C>A	ENST00000248058.1	-	1	197	c.198G>T	c.(196-198)ctG>ctT	p.L66L		NM_001005190.1	NP_001005190.1	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A, member 10	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|stomach(1)	19	Ovarian(108;0.203)					CTACGAAGGACAGGTTGGAGA	0.527000													14	69					3.52763e-06	4.32239e-06	1	1	0
ZFPM2	23414	broad.mit.edu	37	8	106814031	106814031	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:106814031G>A	ENST00000407775.2	+	8	1971	c.1721G>A	c.(1720-1722)cGa>cAa	p.R574Q	RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.R442Q|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.R305Q|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.R442Q|ZFPM2_ENST00000522296.1_3'UTR	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	574					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding	p.R574Q(1)		NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGCAGCAGCCGATGGCAGCAG	0.448000													15	216					0	0	1	0	0
OR6C74	254783	broad.mit.edu	37	12	55641974	55641974	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:55641974C>A	ENST00000343870.4	+	1	993	c.903C>A	c.(901-903)caC>caA	p.H301Q		NM_001005490.1	NP_001005490.1	A6NCV1	O6C74_HUMAN	olfactory receptor, family 6, subfamily C, member 74	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	12						TTTTTAAGCACACAGTCAAAA	0.318000													4	64					1	1	1	1	0
ITGB2	3689	broad.mit.edu	37	21	46321536	46321536	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr21:46321536G>T	ENST00000397850.2	-	7	1064	c.612C>A	c.(610-612)ttC>ttA	p.F204L	ITGB2_ENST00000397852.1_Missense_Mutation_p.F204L|ITGB2_ENST00000397857.1_Missense_Mutation_p.F204L|ITGB2_ENST00000397854.3_Missense_Mutation_p.F147L|ITGB2_ENST00000355153.4_Missense_Mutation_p.F204L|ITGB2_ENST00000302347.5_Missense_Mutation_p.F204L			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	204	VWFA.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	GCACGTGCCTGAAGGCAAACG	0.587000													9	119					2.74318e-10	3.94611e-10	1	1	0
UBAP2L	9898	broad.mit.edu	37	1	154233385	154233385	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:154233385G>T	ENST00000428931.1	+	23	2763	c.2596G>T	c.(2596-2598)Ggc>Tgc	p.G866C	UBAP2L_ENST00000271877.7_Missense_Mutation_p.G877C|UBAP2L_ENST00000361546.2_Missense_Mutation_p.G866C|UBAP2L_ENST00000343815.6_Missense_Mutation_p.G866C	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	866					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACAAAGTTCGGCCGTGGGGA	0.532000													22	50					1.28384e-07	1.67928e-07	1	1	0
ACAP2	23527	broad.mit.edu	37	3	195015484	195015484	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:195015484G>T	ENST00000326793.6	-	18	1959	c.1729C>A	c.(1729-1731)Ccc>Acc	p.P577T		NM_012287.5	NP_036419.3	Q15057	ACAP2_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	577					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(2)	27						ACCGTGGAGGGTAAAGATTCT	0.368000													6	63					5.18039e-06	6.32252e-06	1	1	0
HHLA2	11148	broad.mit.edu	37	3	108072463	108072463	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:108072463A>G	ENST00000357759.5	+	4	668	c.254A>G	c.(253-255)gAt>gGt	p.D85G	HHLA2_ENST00000467761.1_Missense_Mutation_p.D85G|HHLA2_ENST00000491820.1_Missense_Mutation_p.D85G|HHLA2_ENST00000489514.2_Missense_Mutation_p.D85G|HHLA2_ENST00000467562.1_Intron	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	85	Ig-like V-type 1.					integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						GAAAGCCAAGATCCCAGATAT	0.408000													7	56					0	0	1	0	0
GPM6A	2823	broad.mit.edu	37	4	176594895	176594895	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:176594895C>A	ENST00000280187.7	-	4	368	c.323G>T	c.(322-324)gGg>gTg	p.G108V	GPM6A_ENST00000506894.1_Missense_Mutation_p.G97V|GPM6A_ENST00000393658.2_Missense_Mutation_p.G108V|GPM6A_ENST00000515090.1_Missense_Mutation_p.G101V	NM_005277.4	NP_005268.1	P51674	GPM6A_HUMAN	glycoprotein M6A	108						cell surface|integral to membrane				NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33		Breast(14;7.35e-05)|Melanoma(52;0.00909)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;9.21e-19)|Epithelial(43;3.01e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.02e-09)|STAD - Stomach adenocarcinoma(60;0.00083)|GBM - Glioblastoma multiforme(59;0.00168)|LUSC - Lung squamous cell carcinoma(193;0.0388)		TTTGATGGCCCCAGTTGTGAA	0.433000													4	50					0.00024832	0.000282492	1	1	0
RANBP2	5903	broad.mit.edu	37	2	109384162	109384162	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:109384162C>G	ENST00000283195.6	+	20	7293	c.7167C>G	c.(7165-7167)gaC>gaG	p.D2389E		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2389	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						TAACTCCAGACATGACTTTGC	0.348000													33	499					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152558015	152558015	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:152558015G>A	ENST00000367255.5	-	109	20737	c.20136C>T	c.(20134-20136)atC>atT	p.I6712I	SYNE1_ENST00000265368.4_Silent_p.I6712I|SYNE1_ENST00000356820.4_Silent_p.I1236I|SYNE1_ENST00000423061.1_Silent_p.I6641I|SYNE1_ENST00000448038.1_Silent_p.I6641I|SYNE1_ENST00000341594.5_Silent_p.I6324I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6712					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACGCTTGGGATGCTGCTTT	0.522000										HNSCC(10;0.0054)			22	41					0	0	1	0	0
BAK1	578	broad.mit.edu	37	6	33543631	33543631	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:33543631C>A	ENST00000374467.3	-	3	393	c.145G>T	c.(145-147)Gct>Tct	p.A49S	BAK1_ENST00000442998.2_Missense_Mutation_p.A49S|BAK1_ENST00000360661.5_Missense_Mutation_p.A49S	NM_001188.3	NP_001179.1	Q16611	BAK_HUMAN	BCL2-antagonist/killer 1	49					activation of pro-apoptotic gene products|cellular response to mechanical stimulus|cellular response to UV|establishment or maintenance of transmembrane electrochemical gradient|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|release of cytochrome c from mitochondria	integral to mitochondrial outer membrane|pore complex	metal ion binding|protein heterodimerization activity			large_intestine(1)|lung(1)|ovary(1)|skin(1)	4						ACCCCTTCAGCCTCCTGTTCC	0.587000													28	73					5.61819e-17	8.774e-17	1	1	0
EXOC3	11336	broad.mit.edu	37	5	458016	458016	+	Splice_Site	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:458016C>G	ENST00000512944.1	+	6	1355	c.1164_splice	c.e6-1	p.S389_splice	EXOC3_ENST00000315013.5_Splice_Site_p.S389_splice	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	400					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			TTTCTTTAGTCAAACATCATC	0.517000													3	15					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87737565	87737565	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:87737565C>T	ENST00000398204.4	+	5	788	c.465C>T	c.(463-465)caC>caT	p.H155H	ADAM22_ENST00000439864.1_Silent_p.H155H|ADAM22_ENST00000315984.7_Silent_p.H155H|ADAM22_ENST00000265727.7_Silent_p.H155H|ADAM22_ENST00000398209.3_Silent_p.H155H|ADAM22_ENST00000398201.4_Silent_p.H155H	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	155					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CAACATGCCACGGACTTCAGT	0.343000													11	60					0	0	1	0	0
RERGL	79785	broad.mit.edu	37	12	18234245	18234245	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:18234245G>C	ENST00000229002.2	-	6	704	c.498C>G	c.(496-498)atC>atG	p.I166M	RERGL_ENST00000538724.1_Missense_Mutation_p.I165M	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	166	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						TGATAATTCTGATAAACATCA	0.418000													7	82					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	C	A	rs121912656		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:7577547C>A	ENST00000420246.2	-	7	866	c.734G>T	c.(733-735)gGc>gTc	p.G245V	TP53_ENST00000359597.4_Missense_Mutation_p.G245V|TP53_ENST00000269305.4_Missense_Mutation_p.G245V|TP53_ENST00000413465.2_Missense_Mutation_p.G245V|TP53_ENST00000445888.2_Missense_Mutation_p.G245V|TP53_ENST00000455263.2_Missense_Mutation_p.G245V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245D(104)|p.G245V(66)|p.G245A(8)|p.0?(8)|p.?(5)|p.G152V(4)|p.G244_M246>V(3)|p.G152D(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.G245fs*2(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.C238_M246delCNSSCMGGM(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	50					0.0167234	0.0173677	1	1	0
POC1A	25886	broad.mit.edu	37	3	52183873	52183873	+	Silent	SNP	G	G	A	rs145976901		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:52183873G>A	ENST00000394970.2	-	3	551	c.234C>T	c.(232-234)tcC>tcT	p.S78S	POC1A_ENST00000474012.1_Silent_p.S40S|POC1A_ENST00000296484.2_Silent_p.S78S	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	78						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						CTCGGGAGCCGGAAGCAAGCA	0.592000													7	110					0	0	1	0	0
TNFAIP6	7130	broad.mit.edu	37	2	152226737	152226737	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:152226737G>T	ENST00000243347.3	+	4	673	c.598G>T	c.(598-600)Gat>Tat	p.D200Y		NM_007115.3	NP_009046.2	P98066	TSG6_HUMAN	tumor necrosis factor, alpha-induced protein 6	200	CUB.				cell adhesion|cell-cell signaling|inflammatory response|signal transduction		hyaluronic acid binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.131)		TGACAGTTACGATGATGTCCA	0.398000													16	176					9.16793e-09	1.25201e-08	1	1	0
NCOA6	23054	broad.mit.edu	37	20	33345052	33345052	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:33345052C>A	ENST00000374796.2	-	8	4069	c.1499G>T	c.(1498-1500)gGg>gTg	p.G500V	NCOA6_ENST00000359003.2_Missense_Mutation_p.G500V			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	500	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						ACTCTGTGGCCCCTGGTTTGG	0.478000													29	111					7.11191e-15	1.08605e-14	1	1	0
RNF10	9921	broad.mit.edu	37	12	121001395	121001395	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:121001395C>A	ENST00000325954.4	+	9	1961	c.1500C>A	c.(1498-1500)ctC>ctA	p.L500L	RNF10_ENST00000413266.2_Silent_p.L505L	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	500					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCACACGCCTCAGCAGCTCTC	0.537000													4	47					0.00024832	0.000282492	1	1	0
C3orf17	25871	broad.mit.edu	37	3	112736346	112736346	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:112736346G>T	ENST00000314400.5	-	2	401	c.210C>A	c.(208-210)taC>taA	p.Y70*	C3orf17_ENST00000383675.2_Nonsense_Mutation_p.Y70*|C3orf17_ENST00000393857.2_Intron	NM_015412.3	NP_056227.2	Q6NW34	CC017_HUMAN	chromosome 3 open reading frame 17	70						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(2)|lung(6)|prostate(2)|skin(1)	13						TGTGATTGCTGTAAAGGACTG	0.468000													10	79					0.00621372	0.00661942	1	1	0
OR4K5	79317	broad.mit.edu	37	14	20389554	20389554	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:20389554C>T	ENST00000315915.4	+	1	814	c.789C>T	c.(787-789)acC>acT	p.T263T		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		GGCCCTTTACCATCTCTCCTT	0.408000													24	343					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112178169	112178169	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:112178169G>T	ENST00000457016.1	+	16	7258	c.6878G>T	c.(6877-6879)gGt>gTt	p.G2293V	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000508376.2_Missense_Mutation_p.G2293V|APC_ENST00000257430.4_Missense_Mutation_p.G2293V			P25054	APC_HUMAN	adenomatous polyposis coli	2293	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCCCAAATAGGTGGGTCAAGT	0.498000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			9	55					0.000274275	0.000310879	1	1	0
OR2T33	391195	broad.mit.edu	37	1	248436290	248436290	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:248436290T>A	ENST00000318021.2	-	1	848	c.827A>T	c.(826-828)tAt>tTt	p.Y276F		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GAACATAGTATAGAAGGCTGA	0.478000													14	224					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20597334	20597334	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:20597334C>A	ENST00000504154.1	+	31	3449	c.3197C>A	c.(3196-3198)cCa>cAa	p.P1066Q	SLIT2_ENST00000503823.1_Missense_Mutation_p.P1058Q|SLIT2_ENST00000503837.1_Missense_Mutation_p.P1062Q|SLIT2_ENST00000273739.5_Missense_Mutation_p.P1079Q	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1066	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GACTGCACACCAGGGTACGTA	0.453000													23	188					3.28513e-13	4.8961e-13	1	1	0
ENAM	10117	broad.mit.edu	37	4	71508511	71508511	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:71508511C>T	ENST00000396073.3	+	9	1649	c.1368C>T	c.(1366-1368)agC>agT	p.S456S	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	456					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			ATCCAACCAGCCCCTGGAGAA	0.393000													5	61					0	0	1	0	0
NBPF18P	441908	broad.mit.edu	37	1	151993707	151993707	+	RNA	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:151993707C>G	ENST00000432386.1	+	0	2542					NR_103561.1																						GAAGAGATTACAGGAAGGGAG	0.498000													8	109					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150934943	150934943	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:150934943G>A	ENST00000035307.2	+	4	3008	c.1495G>A	c.(1495-1497)Gaa>Aaa	p.E499K	CHPF2_ENST00000495645.1_Missense_Mutation_p.E491K	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	499	Poly-Ala.					Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						CCTGGTGGCTGAAGCTGCTGC	0.627000													11	50					0	0	1	0	0
C2orf15	150590	broad.mit.edu	37	2	99767207	99767207	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:99767207G>C	ENST00000302513.2	+	4	924	c.288G>C	c.(286-288)ggG>ggC	p.G96G	C2orf15_ENST00000409684.1_Silent_p.G96G|TSGA10_ENST00000393483.3_Intron	NM_144706.2	NP_653307.1	Q8WU43	CB015_HUMAN	chromosome 2 open reading frame 15	96										autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(1)	6						GGATTGAAGGGACTGGCACAG	0.388000													10	67					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83129165	83129165	+	Silent	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:83129165T>A	ENST00000329312.4	+	4	1486	c.1449T>A	c.(1447-1449)tcT>tcA	p.S483S		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	483					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						ATGCAGAATCTACTGAAATGG	0.348000													6	21					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811465	140811465	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:140811465C>A	ENST00000509479.2	-	2	1981	c.1125G>T	c.(1123-1125)caG>caT	p.Q375H	MAML3_ENST00000327122.5_Missense_Mutation_p.Q219H	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	375					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					AAGGCCTCGCCTGGGGAGATC	0.592000													7	98					1.06961e-07	1.41399e-07	1	1	0
ZNF25	219749	broad.mit.edu	37	10	38246392	38246392	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:38246392T>C	ENST00000302609.7	-	3	310	c.98A>G	c.(97-99)tAt>tGt	p.Y33C	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				CACATCCTTATACAGAGTCCT	0.433000													7	129					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175962273	175962273	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:175962273C>T	ENST00000264110.2	-	11	1175	c.877G>A	c.(877-879)Gat>Aat	p.D293N	ATF2_ENST00000392543.2_Intron|ATF2_ENST00000538946.1_Missense_Mutation_p.D275N|ATF2_ENST00000409437.1_Missense_Mutation_p.D177N|ATF2_ENST00000487334.2_3'UTR|ATF2_ENST00000345739.5_Missense_Mutation_p.D235N|ATF2_ENST00000426833.3_Missense_Mutation_p.D275N|ATF2_ENST00000409635.1_Missense_Mutation_p.D235N|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000392544.1_Missense_Mutation_p.D293N	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	293					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			TTGACAGTATCACCATTGGTA	0.423000													5	99					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90459321	90459321	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:90459321G>A	ENST00000369393.3	-	25	3671	c.3556C>T	c.(3556-3558)Cac>Tac	p.H1186Y	MDN1_ENST00000428876.1_Missense_Mutation_p.H1186Y			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1186					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AACCGAGGGTGTGCTTTAACA	0.423000													49	141					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130785467	130785467	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:130785467T>C	ENST00000265909.4	-	1	937	c.368A>G	c.(367-369)cAg>cGg	p.Q123R	SNX19_ENST00000533318.1_Intron|SNX19_ENST00000530356.1_Intron|SNX19_ENST00000533214.1_Missense_Mutation_p.Q123R|SNX19_ENST00000528555.1_Intron|SNX19_ENST00000539184.1_Intron	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	123	PXA.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		GGCTGGCTCCTGGCTCACGGA	0.537000													13	65					0	0	1	0	0
CGB7	94027	broad.mit.edu	37	19	49557613	49557613	+	Missense_Mutation	SNP	G	G	A	rs141827342	byFrequency	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:49557613G>A	ENST00000597853.1	-	5	3304	c.433C>T	c.(433-435)Ccc>Tcc	p.P145S	CGB7_ENST00000596965.1_Missense_Mutation_p.P145S|CGB7_ENST00000377280.3_Missense_Mutation_p.P145S|CGB7_ENST00000356213.4_Missense_Mutation_p.P143S					chorionic gonadotropin, beta polypeptide 7											lung(3)|urinary_tract(2)	5		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		AGGCTGGGGGGAGGGGCCTTT	0.637000													17	86					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343371	130343371	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:130343371C>G	ENST00000299164.2	+	8	2508	c.2508C>G	c.(2506-2508)gaC>gaG	p.D836E		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	836	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AGCAGCCGGACGACAGGCCCC	0.706000													15	116					0	0	1	0	0
MALT1	10892	broad.mit.edu	37	18	56363625	56363625	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:56363625C>G	ENST00000348428.3	+	3	662	c.404C>G	c.(403-405)tCa>tGa	p.S135*	RP11-126O1.4_ENST00000588835.1_RNA|MALT1_ENST00000345724.3_Nonsense_Mutation_p.S135*	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	135	Ig-like C2-type 1.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						AACCCAGAGTCAAAGGCAGTC	0.333000			T	BIRC3	MALT								4	24					0	0	1	0	0
NANOS2	339345	broad.mit.edu	37	19	46417799	46417799	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:46417799C>T	ENST00000341294.2	-	1	237	c.153G>A	c.(151-153)ggG>ggA	p.G51G		NM_001029861.2	NP_001025032.1	P60321	NANO2_HUMAN	nanos homolog 2 (Drosophila)	51					germ-line stem cell maintenance|mRNA catabolic process|multicellular organismal development|negative regulation of meiosis|regulation of translation|spermatogenesis	cytoplasmic mRNA processing body|perinuclear region of cytoplasm	RNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)	6		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0668)|Epithelial(262;0.231)		CCCCTGGCGCCCCCAGCCCCT	0.667000													13	50					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	6943263	6943263	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:6943263C>A	ENST00000389658.3	-	62	9076	c.8983G>T	c.(8983-8985)Ggg>Tgg	p.G2995W		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	2995	Laminin G-like 5.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding	p.G2995W(1)		NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACTGCGTTCCCGTCAACAATC	0.493000													28	112					7.41945e-09	1.01547e-08	1	1	0
CELF3	11189	broad.mit.edu	37	1	151681753	151681753	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:151681753G>T	ENST00000290583.4	-	4	1142	c.349C>A	c.(349-351)Ccc>Acc	p.P117T	CELF3_ENST00000290585.4_Missense_Mutation_p.P117T|CELF3_ENST00000470688.1_5'UTR	NM_001172648.1|NM_007185.4	NP_001166119.1|NP_009116.3	Q5SZQ8	CELF3_HUMAN	CUGBP, Elav-like family member 3	117	RRM 2.				nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	mRNA binding|nucleotide binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	21						GTCCCGAAGGGCTCAAACATC	0.617000													13	269					9.31168e-06	1.12759e-05	1	1	0
KCNAB1	7881	broad.mit.edu	37	3	155861016	155861016	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:155861016G>T	ENST00000471742.1	+	1	266	c.49G>T	c.(49-51)Ggt>Tgt	p.G17C	KCNAB1_ENST00000389636.5_Intron|KCNAB1_ENST00000490337.1_Intron	NM_003471.3	NP_003462.2	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	308						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			CCCCAAGCTGGGTCTGCCAAA	0.507000													5	42					0.014758	0.0153781	1	1	0
NEB	4703	broad.mit.edu	37	2	152553972	152553972	+	Splice_Site	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:152553972C>T	ENST00000397345.3	-	15	1460		c.e15-1		NEB_ENST00000604864.1_Splice_Site|NEB_ENST00000409198.1_Splice_Site|NEB_ENST00000427231.2_Splice_Site|NEB_ENST00000603639.1_Splice_Site|NEB_ENST00000172853.10_Splice_Site	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin						muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TATATTTTTTCTGCAAGACAA	0.333000													8	75					0	0	1	0	0
HNRNPF	3185	broad.mit.edu	37	10	43883130	43883130	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:43883130T>G	ENST00000443950.2	-	3	689	c.203A>C	c.(202-204)aAa>aCa	p.K68T	HNRNPF_ENST00000356053.3_Missense_Mutation_p.K68T|HNRNPF_ENST00000544000.1_Missense_Mutation_p.K68T|HNRNPF_ENST00000357065.4_Missense_Mutation_p.K68T|HNRNPF_ENST00000498176.1_5'UTR|HNRNPF_ENST00000337970.3_Missense_Mutation_p.K68T	NM_001098208.1	NP_001091678.1	P52597	HNRPF_HUMAN	heterogeneous nuclear ribonucleoprotein F	68	RRM 1.				regulation of RNA splicing	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|urinary_tract(1)	19						CAGGGCCATTTTTACATCATC	0.488000													8	94					0	0	1	0	0
CLASP1	23332	broad.mit.edu	37	2	122125321	122125321	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:122125321G>C	ENST00000263710.4	-	35	4118	c.3729C>G	c.(3727-3729)aaC>aaG	p.N1243K	CLASP1_ENST00000541859.1_Missense_Mutation_p.N960K|CLASP1_ENST00000397587.3_Missense_Mutation_p.N1183K|CLASP1_ENST00000545861.1_Missense_Mutation_p.N950K|CLASP1_ENST00000455322.2_Missense_Mutation_p.N1199K|CLASP1_ENST00000409078.3_Missense_Mutation_p.N1176K|CLASP1_ENST00000541377.1_Missense_Mutation_p.N1182K	NM_015282.2	NP_056097.1	Q7Z460	CLAP1_HUMAN	cytoplasmic linker associated protein 1	1243					axon guidance|cell division|establishment or maintenance of cell polarity|exit from mitosis|G2/M transition of mitotic cell cycle|microtubule anchoring|microtubule bundle formation|microtubule nucleation|microtubule organizing center organization|mitotic prometaphase|negative regulation of microtubule depolymerization	centrosomal corona|condensed chromosome kinetochore|cortical microtubule cytoskeleton|cytoplasmic microtubule|cytosol|Golgi apparatus|kinetochore microtubule	kinetochore binding|microtubule plus-end binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)	47	Renal(3;0.0496)					GTGAGGTCTTGTTATCCAGAG	0.657000													5	69					0	0	1	0	0
BCL2L14	79370	broad.mit.edu	37	12	12240275	12240275	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:12240275T>G	ENST00000266434.4	+	3	757	c.562T>G	c.(562-564)Ttc>Gtc	p.F188V	BCL2L14_ENST00000589718.1_Missense_Mutation_p.F188V|BCL2L14_ENST00000396367.1_Missense_Mutation_p.F188V|BCL2L14_ENST00000586576.1_Missense_Mutation_p.F221V|BCL2L14_ENST00000308721.5_Missense_Mutation_p.F188V|BCL2L14_ENST00000396369.1_Missense_Mutation_p.F188V	NM_030766.1	NP_110393.1	Q9BZR8	B2L14_HUMAN	BCL2-like 14 (apoptosis facilitator)	188					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			large_intestine(1)|lung(2)|skin(3)	6		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		GGGTCTCTCCTTCCAGCTCCA	0.527000													9	123					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122723166	122723166	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:122723166C>T	ENST00000267199.4	-	10	1382	c.1270G>A	c.(1270-1272)Gtt>Att	p.V424I	RP11-512M8.5_ENST00000535844.1_Missense_Mutation_p.V385I	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	424					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		TAATCCAAAACTTTTTGTTTG	0.363000													11	115					0	0	1	0	0
KIAA1033	23325	broad.mit.edu	37	12	105546208	105546208	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:105546208A>T	ENST00000332180.5	+	26	2824	c.2737A>T	c.(2737-2739)Agg>Tgg	p.R913W		NM_015275.1	NP_056090.1	Q2M389	WAHS7_HUMAN	KIAA1033	913					endosome transport	WASH complex				breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|lung(15)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41						TGATCAATTCAGGCAACTCAT	0.373000													6	65					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44663642	44663642	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:44663642G>T	ENST00000454036.1	+	2	253	c.177G>T	c.(175-177)aaG>aaT	p.K59N	SLC12A5_ENST00000243964.3_Missense_Mutation_p.K36N|SLC12A5_ENST00000539566.1_Missense_Mutation_p.K36N|SLC12A5_ENST00000372315.1_Missense_Mutation_p.K36N	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	59					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACACAGAGAAGGGAAAGGAGT	0.522000													25	116					2.27525e-19	3.60782e-19	1	1	0
SCN10A	6336	broad.mit.edu	37	3	38797308	38797308	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:38797308G>A	ENST00000449082.2	-	10	1431	c.1432C>T	c.(1432-1434)Cgc>Tgc	p.R478C		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	478					sensory perception	voltage-gated sodium channel complex		p.R478S(1)		NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GGATCAGAGCGGGGTGATTTG	0.488000													25	166					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10443779	10443779	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:10443779T>G	ENST00000397077.1	-	6	1226	c.651A>C	c.(649-651)aaA>aaC	p.K217N	ATP2B2_ENST00000352432.4_Missense_Mutation_p.K217N|ATP2B2_ENST00000383800.4_Missense_Mutation_p.K217N|ATP2B2_ENST00000343816.4_Missense_Mutation_p.K217N|ATP2B2_ENST00000360273.2_Missense_Mutation_p.K217N			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	217					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ACTTACCATATTTGACCTGGG	0.577000													32	164					0	0	1	0	0
FAM73A	374986	broad.mit.edu	37	1	78338687	78338687	+	Splice_Site	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:78338687A>T	ENST00000370791.3	+	15	1595		c.e15-1		FAM73A_ENST00000443751.2_Splice_Site_p.Q484_splice	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A							integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		ACTTCCCAGCAGATCCCAGAT	0.408000													22	179					0	0	1	0	0
OTP	23440	broad.mit.edu	37	5	76932725	76932725	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:76932725A>T	ENST00000306422.3	-	2	1506	c.368T>A	c.(367-369)tTc>tAc	p.F123Y	OTP_ENST00000515716.1_5'UTR	NM_032109.2	NP_115485.1	Q5XKR4	OTP_HUMAN	orthopedia homeobox	123						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|pancreas(1)	13		all_lung(232;0.00051)|Lung NSC(167;0.000601)|Ovarian(174;0.0105)|Prostate(461;0.214)		OV - Ovarian serous cystadenocarcinoma(54;9.04e-51)|Epithelial(54;1.62e-45)|all cancers(79;4.4e-41)		AGTCTTGGCGAAGCTCCTCTC	0.637000													31	130					0	0	1	0	0
ZNF362	149076	broad.mit.edu	37	1	33760842	33760842	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:33760842C>T	ENST00000539719.1	+	8	1252	c.1082C>T	c.(1081-1083)tCg>tTg	p.S361L	ZNF362_ENST00000373428.5_Missense_Mutation_p.S361L	NM_152493.2	NP_689706.2	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				ATCCACCTCTCGGCCCACGCC	0.637000											OREG0013342	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	37					0	0	1	0	0
F2R	2149	broad.mit.edu	37	5	76028663	76028663	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:76028663G>T	ENST00000319211.4	+	2	878	c.613G>T	c.(613-615)Gtg>Ttg	p.V205L		NM_001992.3	NP_001983.2	P25116	PAR1_HUMAN	coagulation factor II (thrombin) receptor	205					activation of caspase activity|anatomical structure morphogenesis|connective tissue replacement involved in inflammatory response wound healing|negative regulation of cell proliferation|platelet activation|positive regulation of blood coagulation|positive regulation of cell migration|positive regulation of collagen biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JAK-STAT cascade|positive regulation of MAPKKK cascade|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of transcription, DNA-dependent|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	caveola|extracellular region|Golgi apparatus|integral to plasma membrane|platelet dense tubular network	receptor binding|thrombin receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|lung(7)|ovary(3)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)	Streptokinase(DB00086)	TCTGGCTGTGGTGTATCCCAT	0.527000													32	141					2.47316e-13	3.72174e-13	1	1	0
SMC4	10051	broad.mit.edu	37	3	160134080	160134080	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:160134080C>A	ENST00000357388.3	+	10	1765	c.1314C>A	c.(1312-1314)atC>atA	p.I438I	RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000462787.1_Silent_p.I438I|SMC4_ENST00000360111.2_Silent_p.I438I|SMC4_ENST00000344722.5_Silent_p.I438I|SMC4_ENST00000469762.1_Silent_p.I413I	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	438					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GTAACAATATCATTAATGAAA	0.313000													15	70					0.000308642	0.000349193	1	1	0
CHD6	84181	broad.mit.edu	37	20	40112039	40112039	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:40112039G>C	ENST00000373233.3	-	16	2555	c.2378C>G	c.(2377-2379)cCt>cGt	p.P793R	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	793	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				AATCAGCTTAGGGAGTAGTTT	0.498000													8	52					0	0	1	0	0
GSPT2	23708	broad.mit.edu	37	X	51488283	51488283	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:51488283A>G	ENST00000340438.4	+	1	1803	c.1561A>G	c.(1561-1563)Acg>Gcg	p.T521A		NM_018094.4	NP_060564.2	Q8IYD1	ERF3B_HUMAN	G1 to S phase transition 2	521					cell cycle|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|translational termination	cytoplasm	GTP binding|GTPase activity|protein binding			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Ovarian(276;0.236)					TTCTGGACGCACGTTTGATGT	0.408000													17	47					0	0	1	0	0
ABCB8	11194	broad.mit.edu	37	7	150742328	150742328	+	Silent	SNP	C	C	G	rs144165657	byFrequency	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:150742328C>G	ENST00000358849.4	+	16	2142	c.2049C>G	c.(2047-2049)ggC>ggG	p.G683G	ABCB8_ENST00000297504.6_Silent_p.G700G|ABCB8_ENST00000542328.1_Silent_p.G595G|ABCB8_ENST00000498578.1_Silent_p.G658G|ABCB8_ENST00000356058.4_3'UTR	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	700	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TGAAGAAAGGCGGGCTATACG	0.632000													6	68					0	0	1	0	0
MAPKAP1	79109	broad.mit.edu	37	9	128201249	128201249	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:128201249C>A	ENST00000265960.3	-	12	1818	c.1486G>T	c.(1486-1488)Gac>Tac	p.D496Y	MAPKAP1_ENST00000373503.3_Missense_Mutation_p.D304Y|MAPKAP1_ENST00000373498.1_Missense_Mutation_p.D496Y|MAPKAP1_ENST00000394063.1_Missense_Mutation_p.D304Y|MAPKAP1_ENST00000350766.3_Missense_Mutation_p.D460Y|MAPKAP1_ENST00000483937.1_5'UTR|MAPKAP1_ENST00000373511.2_Missense_Mutation_p.D449Y|MAPKAP1_ENST00000373497.5_Missense_Mutation_p.D209Y	NM_001006617.1	NP_001006618.1	Q9BPZ7	SIN1_HUMAN	mitogen-activated protein kinase associated protein 1	496	Interaction with ATF2.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|response to stress|T cell costimulation	cytoplasmic membrane-bounded vesicle|cytosol|nucleus|plasma membrane	Ras GTPase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(3)	23						GCAAAGTAGTCAGCCCGGGCA	0.552000													16	94					3.45872e-05	4.11594e-05	1	1	0
ESPNL	339768	broad.mit.edu	37	2	239040097	239040097	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:239040097C>T	ENST00000343063.3	+	9	3005	c.2742C>T	c.(2740-2742)gcC>gcT	p.A914A	ESPNL_ENST00000477241.1_3'UTR|ESPNL_ENST00000409506.1_Silent_p.A546A|ESPNL_ENST00000409169.1_Silent_p.A870A	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	914										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GCCGCCGGGCCTGGACCGACG	0.692000													4	23					0	0	1	0	0
CHI3L2	1117	broad.mit.edu	37	1	111773562	111773562	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:111773562C>A	ENST00000445067.2	+	5	1040	c.269C>A	c.(268-270)aCc>aAc	p.T90N	CHI3L2_ENST00000369744.2_Missense_Mutation_p.T80N|CHI3L2_ENST00000524472.1_Missense_Mutation_p.T11N|CHI3L2_ENST00000369748.4_Missense_Mutation_p.T90N|CHI3L2_ENST00000466741.1_Missense_Mutation_p.T11N			Q15782	CH3L2_HUMAN	chitinase 3-like 2	90					chitin catabolic process	extracellular space	cation binding|chitinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		AGTCTCAAAACCAAGTGAGTA	0.428000													5	33					0.000602214	0.000671534	1	1	0
ETFB	2109	broad.mit.edu	37	19	51857841	51857841	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:51857841G>C	ENST00000354232.4	-	1	2519	c.52C>G	c.(52-54)Ctt>Gtt	p.L18V	ETFB_ENST00000309244.4_Intron|CTD-2616J11.11_ENST00000600067.1_Intron	NM_001014763.1	NP_001014763.1	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	0					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity			kidney(2)|large_intestine(1)|lung(3)	6		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		AGGCCTGAAAGAGTGTTTCTC	0.418000													20	91					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140174890	140174890	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:140174890T>A	ENST00000526136.1	+	1	341	c.341T>A	c.(340-342)cTg>cAg	p.L114Q	PCDHA2_ENST00000520672.2_Missense_Mutation_p.L114Q|PCDHA2_ENST00000378132.1_Missense_Mutation_p.L114Q|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACAGGCCGCTGCAGGTTTTC	0.527000													38	144					0	0	1	0	0
PLSCR1	5359	broad.mit.edu	37	3	146246550	146246550	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:146246550C>A	ENST00000342435.4	-	4	573	c.163G>T	c.(163-165)Ggt>Tgt	p.G55C	PLSCR1_ENST00000448787.2_Intron|PLSCR1_ENST00000448205.1_Intron|PLSCR1_ENST00000487389.1_Missense_Mutation_p.G48C	NM_021105.2	NP_066928.1	O15162	PLS1_HUMAN	phospholipid scramblase 1	55					phospholipid scrambling|platelet activation|response to virus	integral to membrane|plasma membrane	calcium ion binding|phospholipid scramblase activity|SH3 domain binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15						GGGCCAGGACCTGAATGGCCG	0.537000													5	79					0.014758	0.0153781	1	1	0
ZNF800	168850	broad.mit.edu	37	7	127014885	127014885	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:127014885G>C	ENST00000393313.1	-	5	1096	c.505C>G	c.(505-507)Cag>Gag	p.Q169E	ZNF800_ENST00000265827.3_Missense_Mutation_p.Q169E|ZNF800_ENST00000393312.1_Missense_Mutation_p.Q169E			Q2TB10	ZN800_HUMAN	zinc finger protein 800	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(8)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	32						TCCTGTATCTGAACTTCGGTT	0.398000													12	132					0	0	1	0	0
PKD1L2	114780	broad.mit.edu	37	16	81253804	81253804	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:81253804C>A	ENST00000599697.1	-	1	171	c.172G>T	c.(172-174)Ggg>Tgg	p.G58W	PKD1L2_ENST00000337114.4_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	58	C-type lectin.				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CCTCCTTGCCCCTCGCACCAG	0.557000													12	106					3.07112e-06	3.79301e-06	1	1	0
GRIN2B	2904	broad.mit.edu	37	12	13720119	13720119	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:13720119A>T	ENST00000279593.3	-	12	2647	c.2438T>A	c.(2437-2439)cTg>cAg	p.L813Q		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	813					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTCAATGTCCAGCTGGCTGCT	0.522000													16	107					0	0	1	0	0
HEPN1	641654	broad.mit.edu	37	11	124789652	124789652	+	Silent	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:124789652T>A	ENST00000408930.5	+	1	507	c.6T>A	c.(4-6)ggT>ggA	p.G2G	HEPACAM_ENST00000298251.4_3'UTR	NM_001037558.2	NP_001032647.2	Q6WQI6	HEPN1_HUMAN	hepatocellular carcinoma, down-regulated 1	2						cytoplasm				large_intestine(1)|lung(1)|stomach(1)	3	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0287)		AGGTGATGGGTAACTGGGGCC	0.547000													8	39					0	0	1	0	0
MACC1	346389	broad.mit.edu	37	7	20199487	20199487	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:20199487T>C	ENST00000400331.5	-	5	805	c.497A>G	c.(496-498)cAc>cGc	p.H166R	MACC1_ENST00000589011.1_Missense_Mutation_p.H166R|MACC1_ENST00000332878.4_Missense_Mutation_p.H166R	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	166					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						CTCTAAGTCGTGTAGTAGGAT	0.423000													24	112					0	0	1	0	0
ITGAV	3685	broad.mit.edu	37	2	187531956	187531956	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:187531956G>T	ENST00000261023.3	+	23	2600	c.2327_splice	c.e23+1	p.G776_splice	ITGAV_ENST00000433736.2_Splice_Site_p.G730_splice|ITGAV_ENST00000374907.3_Splice_Site_p.G740_splice|AC017101.10_ENST00000453665.1_RNA	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	776					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TGAGATAAGAGGGTCAGTATG	0.363000													10	57					9.70103e-10	1.36078e-09	1	1	0
SLC18B1	116843	broad.mit.edu	37	6	133091439	133091439	+	Silent	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:133091439T>C	ENST00000275227.4	-	14	1437	c.1341A>G	c.(1339-1341)gaA>gaG	p.E447E		NM_052831.2	NP_439896.1	Q6NT16	CF192_HUMAN	solute carrier family 18, subfamily B, member 1	447					transmembrane transport	integral to membrane											GAGTAGTTCGTTCCTCCTCTG	0.398000													10	112					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2705694	2705694	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:2705694C>T	ENST00000320876.6	+	14	2183	c.1845C>T	c.(1843-1845)gtC>gtT	p.V615V	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Silent_p.V615V	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	615					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						aatattaGGTCAAGACAATCA	0.299000													5	39					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27456887	27456887	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:27456887G>A	ENST00000264705.4	+	22	3573	c.3411G>A	c.(3409-3411)gtG>gtA	p.V1137V	CAD_ENST00000403525.1_Silent_p.V1074V	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	1137	ATP-grasp 2.|CPSase (Carbamoyl-phosphate synthase).|CPSase B.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AGATTGACGTGGATGCCGTGG	0.562000													5	33					0	0	1	0	0
BFSP1	631	broad.mit.edu	37	20	17475130	17475130	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:17475130C>T	ENST00000377873.3	-	8	1626	c.1587G>A	c.(1585-1587)caG>caA	p.Q529Q	BFSP1_ENST00000544874.1_Silent_p.Q390Q|BFSP1_ENST00000377868.2_Silent_p.Q404Q|BFSP1_ENST00000536626.1_Silent_p.Q390Q	NM_001195.3	NP_001186.1	Q12934	BFSP1_HUMAN	beaded filament structural protein 1, filensin	529	Tail.					cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens	p.Q529Q(1)		central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)|stomach(1)	18						CTTCTTTCTCCTGCAGACCCA	0.542000													11	111					0	0	1	0	0
KLF3	51274	broad.mit.edu	37	4	38690331	38690331	+	Silent	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:38690331A>T	ENST00000261438.5	+	3	488	c.183A>T	c.(181-183)ccA>ccT	p.P61P	KLF3_ENST00000514033.1_Silent_p.P61P	NM_016531.5	NP_057615.3	P57682	KLF3_HUMAN	Kruppel-like factor 3 (basic)	61	Pro-rich.|Repressor domain.				multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(5)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	18						AGATGGAGCCAGTGGACCTCA	0.567000													9	73					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114199072	114199072	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:114199072C>T	ENST00000357077.4	+	16	1816	c.1763C>T	c.(1762-1764)gCc>gTc	p.A588V	ANK2_ENST00000394537.3_Missense_Mutation_p.A588V|ANK2_ENST00000506722.1_Missense_Mutation_p.A567V|ANK2_ENST00000264366.6_Missense_Mutation_p.A588V	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	588					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CGCCGTGCTGCCGCAGATTCT	0.413000													5	31					0	0	1	0	0
CCDC107	203260	broad.mit.edu	37	9	35658646	35658646	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:35658646G>C	ENST00000421582.2	+	2	243	c.180G>C	c.(178-180)cgG>cgC	p.R60R	CCDC107_ENST00000378409.3_Silent_p.R60R|CCDC107_ENST00000378406.1_Silent_p.R60R|CCDC107_ENST00000378407.3_Silent_p.R60R|CCDC107_ENST00000426546.2_Silent_p.R60R|CCDC107_ENST00000327351.2_Silent_p.R60R			Q8WV48	CC107_HUMAN	coiled-coil domain containing 107	60						integral to membrane				endometrium(1)|lung(3)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			AACGCGAGCGGACCCGGGCCG	0.706000													3	11					0	0	1	0	0
TRIM29	23650	broad.mit.edu	37	11	119983130	119983130	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:119983130C>A	ENST00000341846.5	-	9	2180	c.1759G>T	c.(1759-1761)Gcc>Tcc	p.A587S	TRIM29_ENST00000525887.1_5'UTR|TRIM29_ENST00000541857.1_Missense_Mutation_p.A320S|TRIM29_ENST00000528870.1_Missense_Mutation_p.A120S|TRIM29_ENST00000524816.3_Missense_Mutation_p.A153S|TRIM29_ENST00000529044.1_Missense_Mutation_p.A326S	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	587					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GCTCATGGGGCTTCGTTGGAC	0.587000													11	84					4.68919e-08	6.27926e-08	1	1	0
OR2T4	127074	broad.mit.edu	37	1	248525562	248525562	+	Missense_Mutation	SNP	A	A	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:248525562A>C	ENST00000366475.1	+	1	680	c.680A>C	c.(679-681)tAt>tCt	p.Y227S		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCTCACTCTATGAGATTTTC	0.478000													26	199					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91356974	91356974	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:91356974C>T	ENST00000261991.3	-	14	1866	c.1693G>A	c.(1693-1695)Gat>Aat	p.D565N	RPS6KA5_ENST00000536315.2_Missense_Mutation_p.D486N	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	565	Protein kinase 2.				axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AATCCAAAATCAATTATTTTA	0.408000													5	45					0	0	1	0	0
B3GNTL1	146712	broad.mit.edu	37	17	81006548	81006548	+	Silent	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:81006548A>G	ENST00000320865.3	-	2	187	c.174T>C	c.(172-174)agT>agC	p.S58S	B3GNTL1_ENST00000571954.1_5'UTR|B3GNTL1_ENST00000576599.1_5'UTR	NM_001009905.1	NP_001009905.1	Q67FW5	B3GNL_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	58							transferase activity, transferring glycosyl groups			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)	all_cancers(8;0.0396)|all_epithelial(8;0.0556)	BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			TACAAACCTTACTGGCATCAT	0.502000													15	88					0	0	1	0	0
C8orf31	286122	broad.mit.edu	37	8	144130653	144130653	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:144130653T>G	ENST00000395172.1	+	5	735	c.383T>G	c.(382-384)cTt>cGt	p.L128R	C8orf31_ENST00000517653.1_3'UTR	NM_173687.2	NP_775958.1	Q8N9H6	CH031_HUMAN	chromosome 8 open reading frame 31	128										breast(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)	10	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					gggaaccaccttctctactct	0.488000													9	70					0	0	1	0	0
PIEZO2	63895	broad.mit.edu	37	18	10681678	10681678	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:10681678G>A	ENST00000302079.6	-	46	7230	c.7231C>T	c.(7231-7233)Caa>Taa	p.Q2411*	PIEZO2_ENST00000285141.4_Nonsense_Mutation_p.Q266*|PIEZO2_ENST00000538948.1_Nonsense_Mutation_p.Q431*|PIEZO2_ENST00000580640.1_Nonsense_Mutation_p.Q2499*|PIEZO2_ENST00000503781.3_Nonsense_Mutation_p.Q2474*			Q9H5I5	PIEZ2_HUMAN	piezo-type mechanosensitive ion channel component 2	2474						integral to membrane	ion channel activity										GAAAAAGCTTGTATAAATTTG	0.388000													20	113					0	0	1	0	0
PTF1A	256297	broad.mit.edu	37	10	23482681	23482681	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:23482681G>A	ENST00000376504.3	+	2	1037	c.833G>A	c.(832-834)gGa>gAa	p.G278E		NM_178161.2	NP_835455.1	Q7RTS3	PTF1A_HUMAN	pancreas specific transcription factor, 1a	278					endocrine pancreas development|exocrine pancreas development|regulation of transcription, DNA-dependent|tissue development|transcription, DNA-dependent	cytoplasm|transcription factor complex				endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)|skin(1)	7						CCCCTAGCAGGACACTCTCTC	0.507000													29	346					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117389255	117389255	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:117389255T>C	ENST00000321322.6	-	7	1617	c.1616A>G	c.(1615-1617)gAc>gGc	p.D539G	DSCAML1_ENST00000527706.1_Missense_Mutation_p.D269G	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	479	Ig-like C2-type 6.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACGCCCCCGTCGCGGATCTG	0.587000													19	92					0	0	1	0	0
TES	26136	broad.mit.edu	37	7	115889218	115889218	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:115889218G>T	ENST00000358204.4	+	3	473	c.258G>T	c.(256-258)atG>atT	p.M86I	TES_ENST00000485009.1_3'UTR|AC002066.1_ENST00000446355.2_RNA|TES_ENST00000393481.2_Missense_Mutation_p.M77I|TES_ENST00000537767.1_Intron|AC073130.3_ENST00000444244.1_RNA	NM_015641.3	NP_056456.1	Q9UGI8	TES_HUMAN	testis derived transcript (3 LIM domains)	86					negative regulation of cell proliferation	cytoplasm|focal adhesion|nucleus|protein complex	zinc ion binding			endometrium(4)|large_intestine(4)|lung(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	12	Lung NSC(10;0.0137)|all_lung(10;0.0148)	Breast(660;0.0602)	STAD - Stomach adenocarcinoma(10;0.00878)			GAATTCCCATGTATAAACGCA	0.408000													18	120					3.52763e-06	4.32239e-06	1	1	0
TIGD5	84948	broad.mit.edu	37	8	144680972	144680972	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:144680972C>T	ENST00000321385.3	+	1	899	c.752C>T	c.(751-753)cCg>cTg	p.P251L	TIGD5_ENST00000504548.2_Missense_Mutation_p.P300L			E7EWS2	E7EWS2_HUMAN	tigger transposable element derived 5	300					regulation of transcription, DNA-dependent	chromosome, centromeric region	DNA binding			NS(1)|lung(3)|ovary(1)|soft_tissue(1)|urinary_tract(1)	7	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CTGCCGGACCCGCCCAGCCTG	0.721000													3	22					0	0	1	0	0
PAPL	390928	broad.mit.edu	37	19	39591587	39591587	+	Splice_Site	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:39591587A>T	ENST00000331256.5	+	8	1081		c.e8-1		PAPL_ENST00000594229.1_Splice_Site	NM_001004318.2	NP_001004318.2	Q6ZNF0	PAPL_HUMAN								extracellular region	acid phosphatase activity|metal ion binding										CCTTCTCCCTAGAAAGCCAAT	0.637000													14	115					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658395	72658395	+	RNA	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:72658395T>A	ENST00000425256.1	-	0	1516					NR_002164.1																						gtacccgtcgtgggcaccgta	0.463000													15	76					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48707824	48707824	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:48707824A>G	ENST00000316623.5	-	64	8415	c.7960T>C	c.(7960-7962)Tct>Cct	p.S2654P	FBN1_ENST00000561429.1_5'UTR	NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	2654	EGF-like 47; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GCCTGCGCAGAGCCACATTCA	0.567000													6	94					0	0	1	0	0
GSAP	54103	broad.mit.edu	37	7	76984582	76984582	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:76984582G>A	ENST00000257626.7	-	16	1364	c.1286C>T	c.(1285-1287)gCg>gTg	p.A429V		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		GCAGTGCAACGCAGCCATCTT	0.488000													10	97					0	0	1	0	0
OLFM4	10562	broad.mit.edu	37	13	53617258	53617258	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:53617258T>A	ENST00000219022.2	+	4	667	c.589T>A	c.(589-591)Ttg>Atg	p.L197M		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	197					cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		TATGACTCTCTTGGTAGAGAA	0.378000													6	62					0	0	1	0	0
ARNTL2	56938	broad.mit.edu	37	12	27555605	27555605	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:27555605C>T	ENST00000544915.1	+	12	1589	c.1370C>T	c.(1369-1371)tCa>tTa	p.S457L	ARNTL2_ENST00000546179.1_Missense_Mutation_p.S454L|ARNTL2_ENST00000311001.5_Missense_Mutation_p.S477L|ARNTL2_ENST00000542388.1_Missense_Mutation_p.S406L|ARNTL2_ENST00000395901.2_Missense_Mutation_p.S454L|RP11-165P7.1_ENST00000500498.2_RNA|ARNTL2_ENST00000266503.5_Missense_Mutation_p.S491L|ARNTL2_ENST00000261178.5_Missense_Mutation_p.S443L	NM_020183.4	NP_064568.3	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear translocator-like 2	491	PAC.				circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	21	Colorectal(261;0.0847)|Lung SC(9;0.184)					TCTCAATCATCAGAAGGTAAG	0.348000													4	53					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039884	31039884	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:31039884G>A	ENST00000355537.3	+	4	3505	c.3358G>A	c.(3358-3360)Ggc>Agc	p.G1120S		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1120					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGTTTACCCAGGCATGGTTGG	0.567000													11	84					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51111375	51111375	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:51111375C>A	ENST00000395542.2	-	10	1541	c.1357G>T	c.(1357-1359)Ggg>Tgg	p.G453W	COBL_ENST00000265136.7_Missense_Mutation_p.G371W			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	371										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CTGCCAGACCCCAGGGGCAGG	0.622000													11	38					2.80697e-09	3.85027e-09	1	1	0
NETO1	81832	broad.mit.edu	37	18	70450945	70450945	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:70450945C>T	ENST00000327305.6	-	7	1493	c.836G>A	c.(835-837)cGa>cAa	p.R279Q	NETO1_ENST00000583169.1_Missense_Mutation_p.R279Q|NETO1_ENST00000299430.2_Missense_Mutation_p.R278Q	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	279	CUB 2.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CATCTGAAATCGGCTGTTTCG	0.453000													27	121					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10430276	10430276	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:10430276C>A	ENST00000245503.5	-	29	4353	c.3969G>T	c.(3967-3969)agG>agT	p.R1323S	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.R1323S|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1323					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						CTTCAAGTTGCCTCTTTAATT	0.393000													13	46					4.36969e-10	6.19956e-10	1	1	0
GPC3	2719	broad.mit.edu	37	X	132887564	132887564	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:132887564G>T	ENST00000370818.3	-	3	1422	c.977C>A	c.(976-978)aCa>aAa	p.T326K	GPC3_ENST00000543339.1_Missense_Mutation_p.T272K|GPC3_ENST00000394299.2_Missense_Mutation_p.T326K	NM_001164618.1|NM_004484.3	NP_001158090.1|NP_004475.1	P51654	GPC3_HUMAN	glypican 3	326						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|prostate(1)|skin(2)	36	Acute lymphoblastic leukemia(192;0.000127)					ATCATGGATTGTTGAAAAGAG	0.438000			"""T, D, Mis, N, F, S"""			Wilms tumour			Simpson-Golabi-Behmel syndrome				34	84					4.3181e-19	6.82965e-19	1	1	0
TMEM198	130612	broad.mit.edu	37	2	220412305	220412305	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:220412305C>T	ENST00000344458.2	+	4	829	c.244C>T	c.(244-246)Cga>Tga	p.R82*	TMEM198_ENST00000373883.3_Nonsense_Mutation_p.R82*|RP11-256I23.1_ENST00000596829.1_RNA			Q66K66	TM198_HUMAN	transmembrane protein 198	82	Leu-rich.					integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	16		Renal(207;0.0376)		Epithelial(149;6.49e-08)|all cancers(144;6.45e-06)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		CCTCTGCTACCGAGAGCGGGT	0.632000													74	328					0	0	1	0	0
CLHC1	130162	broad.mit.edu	37	2	55449427	55449427	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:55449427T>G	ENST00000401408.1	-	3	466	c.121A>C	c.(121-123)Agt>Cgt	p.S41R	CLHC1_ENST00000406437.2_5'UTR|CLHC1_ENST00000407122.1_Missense_Mutation_p.S41R|CLHC1_ENST00000406076.1_Intron|CLHC1_ENST00000494539.1_Intron	NM_152385.2	NP_689598.2			clathrin heavy chain linker domain containing 1																		CCTTCCTCACTACAGCCCAGT	0.348000													14	96					0	0	1	0	0
KLHL5	51088	broad.mit.edu	37	4	39077641	39077641	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:39077641C>G	ENST00000261425.3	+	3	592	c.440C>G	c.(439-441)tCa>tGa	p.S147*	KLHL5_ENST00000504108.1_Nonsense_Mutation_p.S193*|KLHL5_ENST00000359687.2_Nonsense_Mutation_p.S193*|KLHL5_ENST00000381930.3_Nonsense_Mutation_p.S193*|KLHL5_ENST00000508137.2_Nonsense_Mutation_p.S6*|KLHL5_ENST00000261426.5_Intron	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5	193						cytoplasm|cytoskeleton	actin binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						CCATGTACATCAGATGAATTT	0.328000													5	102					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58633194	58633194	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:58633194C>T	ENST00000317147.5	-	2	380	c.48G>A	c.(46-48)ctG>ctA	p.L16L	CNOT1_ENST00000441024.2_Silent_p.L16L|CNOT1_ENST00000569240.1_Silent_p.L16L	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	16					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		AATTGTCCACCAGGTAGCTGA	0.483000													10	77					0	0	1	0	0
KCNH5	27133	broad.mit.edu	37	14	63468160	63468160	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:63468160A>G	ENST00000322893.7	-	4	590	c.322T>C	c.(322-324)Tat>Cat	p.Y108H	KCNH5_ENST00000394968.1_Missense_Mutation_p.Y50H|KCNH5_ENST00000420622.2_Missense_Mutation_p.Y108H|KCNH5_ENST00000394964.2_Missense_Mutation_p.Y50H	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	108	PAC.				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		ATTTGCATATAAAACCAAACA	0.433000													11	29					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222462	140222462	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:140222462C>A	ENST00000531613.1	+	1	1556	c.1556C>A	c.(1555-1557)gCg>gAg	p.A519E	PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.A519E|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGTGTACGCGCTGCAGCCG	0.682000													35	72					1.04594e-18	1.64589e-18	1	1	0
DAB2	1601	broad.mit.edu	37	5	39383274	39383274	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:39383274A>T	ENST00000320816.6	-	10	1254	c.787T>A	c.(787-789)Tgt>Agt	p.C263S	DAB2_ENST00000339788.6_Intron|DAB2_ENST00000509337.1_Missense_Mutation_p.C242S|DAB2_ENST00000545653.1_Missense_Mutation_p.C242S	NM_001343.3	NP_001334.2	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	263					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GGAAGAGAACAGGAGGTGATG	0.438000													17	134					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87144691	87144691	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:87144691G>T	ENST00000265724.3	-	26	3555	c.3138C>A	c.(3136-3138)acC>acA	p.T1046T	ABCB1_ENST00000543898.1_Silent_p.T982T|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1046	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TGTCCGGTCGGGTGGGATAGT	0.498000													8	51					5.18039e-06	6.32252e-06	1	1	0
TRIM49C	642612	broad.mit.edu	37	11	89774402	89774402	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:89774402G>T	ENST00000448984.1	+	8	1372	c.1043G>T	c.(1042-1044)gGg>gTg	p.G348V	TRIM49C_ENST00000432771.1_Intron	NM_001195234.1	NP_001182163.1	P0CI26	T49L2_HUMAN	tripartite motif containing 49C	348	B30.2/SPRY.					intracellular	zinc ion binding			endometrium(3)|kidney(1)|lung(4)	8						GTCCATGTAGGGGACTCCTGG	0.448000													10	33					3.07112e-06	3.79301e-06	1	1	0
OSBPL8	114882	broad.mit.edu	37	12	76763448	76763448	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:76763448G>C	ENST00000261183.3	-	20	2688	c.2209C>G	c.(2209-2211)Ctc>Gtc	p.L737V	OSBPL8_ENST00000393249.2_Missense_Mutation_p.L695V|OSBPL8_ENST00000393250.4_Missense_Mutation_p.L695V	NM_020841.4	NP_065892.1	Q9BZF1	OSBL8_HUMAN	oxysterol binding protein-like 8	737					lipid transport		lipid binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(2)	28						TCTCCTGTGAGTGGATCAAGT	0.348000													6	94					0	0	1	0	0
ZNF550	162972	broad.mit.edu	37	19	58058874	58058874	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:58058874G>C	ENST00000325134.5	-	3	798	c.642C>G	c.(640-642)ctC>ctG	p.L214L	ZNF549_ENST00000594943.1_Intron|ZNF550_ENST00000457177.1_Silent_p.L246L|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000506609.2_Silent_p.L205L|ZNF550_ENST00000601415.1_Intron			Q7Z398	ZN550_HUMAN	zinc finger protein 550	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	7		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGTGCCGAATGAGAGTTGAGC	0.507000													5	77					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60893644	60893644	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:60893644G>C	ENST00000252999.3	-	53	7171	c.7105C>G	c.(7105-7107)Caa>Gaa	p.Q2369E		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2369	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCGCGGGTTTGTGTGGCCAGT	0.677000													24	55					0	0	1	0	0
TBL1Y	90665	broad.mit.edu	37	Y	6955407	6955407	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrY:6955407C>T	ENST00000383032.1	+	17	2027	c.1380C>T	c.(1378-1380)ttC>ttT	p.F460F	TBL1Y_ENST00000346432.3_Silent_p.F460F|TBL1Y_ENST00000355162.2_Silent_p.F460F	NM_033284.1	NP_150600.1	Q9BQ87	TBL1Y_HUMAN	transducin (beta)-like 1, Y-linked	460					transcription, DNA-dependent					kidney(1)|large_intestine(4)|lung(2)|skin(1)	8						GTGTAGCTTTCAGCCCCGATG	0.463000													10	60					0	0	1	0	0
ZGLP1	100125288	broad.mit.edu	37	19	10418891	10418891	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:10418891T>G	ENST00000403903.3	-	1	1665	c.467A>C	c.(466-468)gAc>gCc	p.D156A	ZGLP1_ENST00000403352.1_Missense_Mutation_p.D72A|FDX1L_ENST00000541276.1_3'UTR|CTD-2369P2.10_ENST00000452032.2_3'UTR	NM_001103167.1	NP_001096637.1	P0C6A0	ZGLP1_HUMAN	zinc finger, GATA-like protein 1	156					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(2)|ovary(1)	6						CAGGCTGGAGTCCGGCTTTAT	0.632000													18	56					0	0	1	0	0
FAM198B	51313	broad.mit.edu	37	4	159092390	159092390	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:159092390G>C	ENST00000296530.8	-	2	759	c.138C>G	c.(136-138)atC>atG	p.I46M	RP11-597D13.9_ENST00000509463.1_RNA|FAM198B_ENST00000592057.1_Missense_Mutation_p.I46M|FAM198B_ENST00000589306.1_Intron|FAM198B_ENST00000393807.5_Missense_Mutation_p.I46M|RP11-597D13.9_ENST00000503611.1_RNA|FAM198B_ENST00000585682.1_Missense_Mutation_p.I46M	NM_016613.6	NP_057697.2	Q6UWH4	F198B_HUMAN	family with sequence similarity 198, member B	46						Golgi membrane|integral to membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(14)|skin(2)|urinary_tract(1)	26						AGCCCAAGTAGATGGCACACG	0.662000													8	55					0	0	1	0	0
NLRP1	22861	broad.mit.edu	37	17	5462840	5462840	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:5462840C>A	ENST00000345221.3	-	4	1730	c.1176G>T	c.(1174-1176)ccG>ccT	p.P392P	NLRP1_ENST00000262467.5_Silent_p.P392P|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000354411.3_Silent_p.P392P|NLRP1_ENST00000269280.4_Silent_p.P392P|NLRP1_ENST00000577119.1_Silent_p.P392P|NLRP1_ENST00000572272.1_Silent_p.P392P	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	392	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TAATGGGAGCCGGAGTGGCTG	0.572000													27	53					8.24728e-16	1.27514e-15	1	1	0
ZNF532	55205	broad.mit.edu	37	18	56585970	56585970	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:56585970G>T	ENST00000336078.4	+	4	1227	c.451G>T	c.(451-453)Gac>Tac	p.D151Y	ZNF532_ENST00000591230.1_Missense_Mutation_p.D151Y|ZNF532_ENST00000591083.1_Missense_Mutation_p.D151Y|ZNF532_ENST00000591808.1_Missense_Mutation_p.D151Y|ZNF532_ENST00000589288.1_Missense_Mutation_p.D151Y	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	151					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						TGACCCCCCTGACAAGGAGGA	0.537000													31	133					7.68411e-24	1.22787e-23	1	1	0
RBM45	129831	broad.mit.edu	37	2	178981057	178981057	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:178981057C>G	ENST00000286070.5	+	2	461	c.369C>G	c.(367-369)atC>atG	p.I123M		NM_152945.2	NP_694453.2	Q8IUH3	RBM45_HUMAN	RNA binding motif protein 45	123	RRM 2.				cell differentiation|nervous system development	cytoplasm|nucleus	nucleotide binding|RNA binding	p.I123I(1)		endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.00957)|all cancers(119;0.037)			TTACAAGAATCTTTGTTATGA	0.358000													19	139					0	0	1	0	0
PPP1R7	5510	broad.mit.edu	37	2	242092999	242092999	+	Missense_Mutation	SNP	G	G	T	rs140300724		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:242092999G>T	ENST00000234038.6	+	2	635	c.161G>T	c.(160-162)cGg>cTg	p.R54L	PPP1R7_ENST00000404405.3_Missense_Mutation_p.R54L|PPP1R7_ENST00000272983.8_Intron|PPP1R7_ENST00000407025.1_Missense_Mutation_p.R54L|PPP1R7_ENST00000406106.3_Missense_Mutation_p.R54L|PPP1R7_ENST00000402734.1_Intron|PPP1R7_ENST00000401987.1_Intron	NM_002712.1	NP_002703.1	Q15435	PP1R7_HUMAN	protein phosphatase 1, regulatory subunit 7	54						cytoplasm|nucleus	protein binding|protein phosphatase type 1 regulator activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)	23		all_cancers(19;6.1e-33)|all_epithelial(40;1.07e-13)|Breast(86;0.000141)|Renal(207;0.00528)|all_lung(227;0.0446)|Ovarian(221;0.104)|Lung NSC(271;0.115)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.92e-32)|all cancers(36;5.35e-29)|OV - Ovarian serous cystadenocarcinoma(60;3.4e-14)|Kidney(56;4.23e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.24e-08)|BRCA - Breast invasive adenocarcinoma(100;3.56e-06)|Lung(119;0.000588)|LUSC - Lung squamous cell carcinoma(224;0.0048)|Colorectal(34;0.0137)|COAD - Colon adenocarcinoma(134;0.096)		GGGGAGGAGCGGGGGGAGGAG	0.627000													12	81					5.50884e-06	6.71017e-06	1	1	0
SLCO2A1	6578	broad.mit.edu	37	3	133663999	133663999	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:133663999G>A	ENST00000310926.4	-	10	1674	c.1401C>T	c.(1399-1401)ctC>ctT	p.L467L	SLCO2A1_ENST00000493729.1_Silent_p.L391L	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	467	Kazal-like.				sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GGCAAGGGGAGAGGTACTCGA	0.577000													23	235					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105361677	105361677	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:105361677C>T	ENST00000297581.2	+	2	946	c.897C>T	c.(895-897)ccC>ccT	p.P299P	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	299					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											TTTTCCTCCCCATACTTATCC	0.478000													15	195					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981408	70981408	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:70981408G>T	ENST00000276594.2	-	2	889	c.688C>A	c.(688-690)Cca>Aca	p.P230T		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GAGCTGTCTGGGGGGACCAGG	0.617000													13	87					1.5842e-08	2.15396e-08	1	1	0
CLSTN2	64084	broad.mit.edu	37	3	140178489	140178489	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:140178489C>A	ENST00000458420.3	+	7	1290	c.1100C>A	c.(1099-1101)cCc>cAc	p.P367H	RP11-68L1.2_ENST00000503357.1_RNA	NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	367					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GCCAAAGTCCCCGATGGGATT	0.572000										HNSCC(16;0.037)			4	57					0.00024832	0.000282492	1	1	0
SLX4	84464	broad.mit.edu	37	16	3640014	3640014	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:3640014T>C	ENST00000294008.3	-	12	4265	c.3625A>G	c.(3625-3627)Aga>Gga	p.R1209G		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1209	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						GCTTCGCTTCTTGGTGGGCTC	0.552000								Direct reversal of damage					24	99					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10430275	10430275	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:10430275G>A	ENST00000245503.5	-	29	4354	c.3970C>T	c.(3970-3972)Caa>Taa	p.Q1324*	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Nonsense_Mutation_p.Q1324*|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1324					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TCTTCAAGTTGCCTCTTTAAT	0.388000													12	46					0	0	1	0	0
NKRF	55922	broad.mit.edu	37	X	118723608	118723608	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:118723608C>G	ENST00000371527.1	-	2	2432	c.1780G>C	c.(1780-1782)Gat>Cat	p.D594H	NKRF_ENST00000487600.1_Intron|NKRF_ENST00000542113.1_Missense_Mutation_p.D609H|NKRF_ENST00000304449.5_Missense_Mutation_p.D594H	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	594	G-patch.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						CTCTCTACATCCAGACCAAGC	0.478000													32	99					0	0	1	0	0
MCOLN1	57192	broad.mit.edu	37	19	7598408	7598408	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:7598408G>T	ENST00000264079.6	+	13	1700		c.e13-1			NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1						calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCTCTCCCCAGCATCCCGGCG	0.677000													4	21					0.00024832	0.000282492	1	1	0
MEOX2	4223	broad.mit.edu	37	7	15652098	15652098	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:15652098C>A	ENST00000262041.5	-	3	1238	c.829G>T	c.(829-831)Gca>Tca	p.A277S		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	277					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		AGGGTGGCTGCACCAATTCCC	0.517000													19	131					1.33834e-09	1.85631e-09	1	1	0
FAM86DP	692099	broad.mit.edu	37	3	75471349	75471349	+	RNA	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:75471349T>C	ENST00000459803.1	-	0	1792					NR_024241.1																						CCGCAGCTTCTTGGAGTGTCA	0.597000													9	36					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214788275	214788275	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:214788275A>T	ENST00000366955.3	+	3	431	c.263A>T	c.(262-264)cAt>cTt	p.H88L		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	88	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		AAGATTTCTCATGAACTTCAA	0.358000													12	75					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39644501	39644501	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:39644501C>A	ENST00000265708.4	-	10	986	c.883G>T	c.(883-885)Gtt>Ttt	p.V295F	ADAM2_ENST00000347580.4_Missense_Mutation_p.V276F|ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000521880.1_Missense_Mutation_p.V295F	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	295	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ACCAGAACAACACCTCCTGCA	0.303000													8	63					7.48243e-07	9.52588e-07	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155156193	155156193	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:155156193G>T	ENST00000357232.3	-	25	8245	c.8246C>A	c.(8245-8247)tCt>tAt	p.S2749Y		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2749					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		AATAAAGACAGACTCTTTTCT	0.443000													11	69					6.40141e-05	7.51681e-05	1	1	0
IFI44L	10964	broad.mit.edu	37	1	79093907	79093907	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:79093907A>G	ENST00000370751.4	+	2	486	c.307A>G	c.(307-309)Aca>Gca	p.T103A	IFI44L_ENST00000476521.1_Intron|IFI44L_ENST00000342282.3_Intron	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	103						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						ACTCTTAAATACAGCACCAAA	0.289000													6	51					0	0	1	0	0
RHD	6007	broad.mit.edu	37	1	25611185	25611185	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:25611185G>C	ENST00000328664.4	+	2	425	c.270G>C	c.(268-270)tgG>tgC	p.W90C	RHD_ENST00000342055.5_Missense_Mutation_p.W90C|RHD_ENST00000423253.1_3'UTR|RHD_ENST00000454452.2_Missense_Mutation_p.W90C|RHD_ENST00000568195.1_Missense_Mutation_p.W90C|RHD_ENST00000423810.2_Missense_Mutation_p.W90C|RHD_ENST00000417538.2_Missense_Mutation_p.W90C|RHD_ENST00000357542.4_Missense_Mutation_p.W90C	NM_016124.3	NP_057208.2	Q02161	RHD_HUMAN	Rh blood group, D antigen	90						integral to plasma membrane				breast(2)|large_intestine(4)|lung(7)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;7.39e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;6.43e-07)|STAD - Stomach adenocarcinoma(196;0.000332)|BRCA - Breast invasive adenocarcinoma(304;0.000438)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.000908)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GTGTGCAGTGGGCAATCCTGC	0.577000													4	70					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87424073	87424073	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:87424073G>A	ENST00000517970.1	+	9	1338	c.1031G>A	c.(1030-1032)gGg>gAg	p.G344E	WWP1_ENST00000265428.4_Missense_Mutation_p.G344E|WWP1_ENST00000349423.2_Missense_Mutation_p.G126E|WWP1_ENST00000341922.2_Missense_Mutation_p.G214E	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	344					central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						CAGCAGTCTGGGAATGCCAAC	0.418000													13	52					0	0	1	0	0
GNL3L	54552	broad.mit.edu	37	X	54569698	54569698	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:54569698G>C	ENST00000336470.4	+	7	588	c.449G>C	c.(448-450)tGc>tCc	p.C150S	GNL3L_ENST00000360845.2_Missense_Mutation_p.C150S|GNL3L_ENST00000489691.1_3'UTR	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	150					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						CCATTAGGCTGCCGCTGCTTC	0.542000													5	22					0	0	1	0	0
MANEA	79694	broad.mit.edu	37	6	96034808	96034808	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:96034808G>T	ENST00000358812.4	+	2	627	c.493G>T	c.(493-495)Gat>Tat	p.D165Y	MANEA_ENST00000369293.1_Missense_Mutation_p.D165Y	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	165	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		CAGTTCTCGGGATCCTTCTGT	0.398000													32	105					1.99505e-19	3.17162e-19	1	1	0
ERCC4	2072	broad.mit.edu	37	16	14020516	14020516	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:14020516G>A	ENST00000311895.7	+	3	496	c.487G>A	c.(487-489)Gct>Act	p.A163T	ERCC4_ENST00000575156.1_Missense_Mutation_p.A163T	NM_005236.2	NP_005227.1	Q92889	XPF_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 4	163					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(5)|lung(12)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	38						TTTTATTAAAGCTTTCACAGA	0.408000			"""Mis, N, F"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				32	129					0	0	1	0	0
SPIC	121599	broad.mit.edu	37	12	101876625	101876625	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:101876625T>G	ENST00000551346.1	+	5	425	c.266T>G	c.(265-267)aTa>aGa	p.I89R	SPIC_ENST00000299272.5_Missense_Mutation_p.I89R			Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	89						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	22						CTGCAGAACATAACTGAAAAC	0.398000													10	228					0	0	1	0	0
TRPV4	59341	broad.mit.edu	37	12	110252418	110252418	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:110252418C>A	ENST00000418703.2	-	1	278	c.184G>T	c.(184-186)Gat>Tat	p.D62Y	TRPV4_ENST00000392719.2_Missense_Mutation_p.D62Y|TRPV4_ENST00000346520.2_Missense_Mutation_p.D62Y|TRPV4_ENST00000261740.2_Missense_Mutation_p.D62Y|TRPV4_ENST00000544971.1_Missense_Mutation_p.D62Y|TRPV4_ENST00000541794.1_Missense_Mutation_p.D62Y|TRPV4_ENST00000537083.1_Missense_Mutation_p.D62Y|TRPV4_ENST00000536838.1_Missense_Mutation_p.D28Y	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	62					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						GGTCGCCCATCGCCTGGGCCA	0.627000													4	38					1.23904e-05	1.48877e-05	1	1	0
CX3CR1	1524	broad.mit.edu	37	3	39307746	39307746	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:39307746G>A	ENST00000541347.1	-	2	494	c.255C>T	c.(253-255)ccC>ccT	p.P85P	CX3CR1_ENST00000358309.3_Silent_p.P117P|CX3CR1_ENST00000399220.2_Silent_p.P85P|CX3CR1_ENST00000542107.1_Silent_p.P85P	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	85					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GAGTCCAGAAGGGCAAAGTGG	0.463000													9	133					0	0	1	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16060378	16060378	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:16060378G>T	ENST00000375799.3	+	20	3236	c.3009G>T	c.(3007-3009)caG>caT	p.Q1003H	PLEKHM2_ENST00000477849.1_3'UTR|RP11-288I21.1_ENST00000453804.1_RNA|PLEKHM2_ENST00000375793.2_Missense_Mutation_p.Q983H	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	1003					Golgi organization	cytoplasm	kinesin binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GCGCCTGGCAGCGGAGCGACA	0.652000													3	35					0.115264	0.118122	1	1	0
SLC27A2	11001	broad.mit.edu	37	15	50474890	50474890	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:50474890A>T	ENST00000267842.5	+	1	498	c.266A>T	c.(265-267)aAt>aTt	p.N89I	SLC27A2_ENST00000380902.4_Missense_Mutation_p.N89I	NM_003645.3	NP_003636.2	O14975	S27A2_HUMAN	solute carrier family 27 (fatty acid transporter), member 2	89					bile acid biosynthetic process|fatty acid alpha-oxidation	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity|phytanate-CoA ligase activity|pristanate-CoA ligase activity			NS(1)|breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_lung(180;0.00177)		all cancers(107;1.16e-06)|GBM - Glioblastoma multiforme(94;0.000113)		CGGCGCAGCAATCAAGTGGCC	0.667000													7	98					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140181056	140181056	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:140181056C>T	ENST00000522353.2	+	1	274	c.274C>T	c.(274-276)Cgc>Tgc	p.R92C	PCDHA2_ENST00000520672.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.R92C|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGGATAGACCGCGAGGAACT	0.587000													19	227					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196436869	196436869	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:196436869G>T	ENST00000367433.5	-	7	608	c.507C>A	c.(505-507)aaC>aaA	p.N169K	KCNT2_ENST00000367431.4_Missense_Mutation_p.N169K|KCNT2_ENST00000451324.2_De_novo_Start_InFrame|KCNT2_ENST00000294725.8_Missense_Mutation_p.N169K			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	169						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CAAGCCAACAGTTCAGAAAGA	0.299000													4	48					0.00909568	0.00962342	1	1	0
MXRA5	25878	broad.mit.edu	37	X	3241187	3241187	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:3241187G>T	ENST00000217939.6	-	5	2693	c.2539C>A	c.(2539-2541)Cta>Ata	p.L847I		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	847						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TCACCAAGTAGAGGTACATCT	0.478000													18	56					3.52763e-06	4.32239e-06	1	1	0
PRODH2	58510	broad.mit.edu	37	19	36293101	36293101	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:36293101A>G	ENST00000301175.3	-	10	1435	c.1418T>C	c.(1417-1419)cTa>cCa	p.L473P		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	473					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ACCCAGTGCTAGAGAGACGTG	0.572000													38	163					0	0	1	0	0
SPAG6	9576	broad.mit.edu	37	10	22680715	22680715	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:22680715G>T	ENST00000376603.2	+	8	1433	c.1291G>T	c.(1291-1293)Gca>Tca	p.A431S	SPAG6_ENST00000538630.1_Missense_Mutation_p.A330S|SPAG6_ENST00000376601.1_Missense_Mutation_p.A116S|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376624.3_Missense_Mutation_p.A355S|SPAG6_ENST00000313311.6_Missense_Mutation_p.A355S			O75602	SPAG6_HUMAN	sperm associated antigen 6	355					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TATTAAGGCTGCAGCTGCTTG	0.478000													8	56					7.48243e-07	9.52588e-07	1	1	0
BCL3	602	broad.mit.edu	37	19	45262867	45262867	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:45262867A>T	ENST00000164227.5	+	9	1604	c.1360A>T	c.(1360-1362)Agc>Tgc	p.S454C		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	454	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				TCCAGGAGGCAGCTGAGGGGG	0.662000			T	IGH@	CLL								12	64					0	0	1	0	0
UGT3A2	167127	broad.mit.edu	37	5	36049053	36049053	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:36049053G>A	ENST00000282507.3	-	4	882	c.781C>T	c.(781-783)Ctg>Ttg	p.L261L	UGT3A2_ENST00000513300.1_Silent_p.L227L|UGT3A2_ENST00000545528.1_Intron|UGT3A2_ENST00000504954.1_Intron	NM_174914.3	NP_777574.2	Q3SY77	UD3A2_HUMAN	UDP glycosyltransferase 3 family, polypeptide A2	261						integral to membrane	glucuronosyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	43	all_lung(31;0.000179)		Lung(74;0.111)|Epithelial(62;0.113)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGGGAAGCAGAGGTCGAGCA	0.428000													14	93					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144994145	144994145	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:144994145C>G	ENST00000322810.4	-	32	10424	c.10255G>C	c.(10255-10257)Gag>Cag	p.E3419Q	PLEC_ENST00000345136.3_Missense_Mutation_p.E3282Q|PLEC_ENST00000356346.3_Missense_Mutation_p.E3268Q|PLEC_ENST00000527096.1_Missense_Mutation_p.E3305Q|PLEC_ENST00000436759.2_Missense_Mutation_p.E3309Q|PLEC_ENST00000398774.2_Missense_Mutation_p.E3250Q|PLEC_ENST00000354958.2_Missense_Mutation_p.E3260Q|PLEC_ENST00000357649.2_Missense_Mutation_p.E3286Q|PLEC_ENST00000354589.3_Missense_Mutation_p.E3282Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3419	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ATGACCTTCTCCACGGTGACC	0.622000													7	112					0	0	1	0	0
KIF19	124602	broad.mit.edu	37	17	72324566	72324566	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:72324566G>A	ENST00000389916.4	+	2	180	c.42G>A	c.(40-42)gtG>gtA	p.V14V		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	14	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCTCCCAGGTGGCGCTTCGGG	0.612000													4	7					0	0	1	0	0
TRAF3IP3	80342	broad.mit.edu	37	1	209936007	209936007	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:209936007G>T	ENST00000367024.1	+	4	1009	c.493_splice	c.e4+1	p.G165_splice	TRAF3IP3_ENST00000400959.3_Splice_Site_p.G145_splice|TRAF3IP3_ENST00000367025.3_Splice_Site_p.G165_splice|TRAF3IP3_ENST00000367026.3_Splice_Site_p.G145_splice|TRAF3IP3_ENST00000010338.4_Splice_Site_p.G145_splice			Q9Y228	T3JAM_HUMAN	TRAF3 interacting protein 3	165						integral to membrane	protein binding			breast(2)|endometrium(1)|large_intestine(8)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32				OV - Ovarian serous cystadenocarcinoma(81;0.045)		ACACCACCGTGGTAAGAGCAG	0.597000													15	62					1.99824e-07	2.59729e-07	1	1	0
CHRDL2	25884	broad.mit.edu	37	11	74417561	74417561	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:74417561C>T	ENST00000376332.3	-	6	1049	c.553G>A	c.(553-555)Gag>Aag	p.E185K	CHRDL2_ENST00000534159.1_5'UTR|CHRDL2_ENST00000263671.5_Missense_Mutation_p.E185K	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	185					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					ACACTGTCCTCTTCATCCGAT	0.602000													7	77					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58579564	58579564	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:58579564T>C	ENST00000506786.1	+	5	2140	c.1586T>C	c.(1585-1587)aTt>aCt	p.I529T	ZNF135_ENST00000359978.6_Intron|ZNF135_ENST00000313434.5_Missense_Mutation_p.I571T|ZNF135_ENST00000511556.1_Missense_Mutation_p.I583T|ZNF135_ENST00000401053.4_Missense_Mutation_p.I595T|ZNF135_ENST00000439855.2_Missense_Mutation_p.I571T			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	583					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		CACCAGAGGATTCACACCAAG	0.527000													8	153					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55725892	55725892	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:55725892C>T	ENST00000379906.2	+	5	1101	c.846C>T	c.(844-846)gtC>gtT	p.V282V	SLC6A2_ENST00000567238.1_Silent_p.V177V|SLC6A2_ENST00000566163.1_Intron|SLC6A2_ENST00000568943.1_Silent_p.V282V|SLC6A2_ENST00000219833.8_Silent_p.V282V|SLC6A2_ENST00000561820.1_Silent_p.V282V|SLC6A2_ENST00000414754.3_Silent_p.V282V	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	282					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TCCATGGCGTCACGCTGCCCG	0.582000													13	70					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78472358	78472358	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:78472358T>A	ENST00000377211.4	-	8	1728	c.1576A>T	c.(1576-1578)Agt>Tgt	p.S526C	EDNRB_ENST00000446573.1_Intron|EDNRB_ENST00000334286.5_Missense_Mutation_p.S436C	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	436					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	TATTTATTACTGGAACGGAAG	0.358000													4	42					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119934839	119934839	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:119934839G>C	ENST00000361035.4	+	7	1200	c.917G>C	c.(916-918)gGa>gCa	p.G306A	HAO2_ENST00000325945.3_Missense_Mutation_p.G293A	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	293	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CTGGCCCTTGGAGCTAAGTGC	0.512000													5	104					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881511	228881511	+	Silent	SNP	C	C	T	rs142178318		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:228881511C>T	ENST00000392056.3	-	7	4105	c.4059G>A	c.(4057-4059)gcG>gcA	p.A1353A	SPHKAP_ENST00000344657.5_Silent_p.A1353A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1353						cytoplasm	protein binding	p.A1353A(1)		NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		ACATCCTGCTCGCAGCTAATC	0.502000													20	95					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71833872	71833872	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:71833872C>A	ENST00000266674.5	+	1	323	c.12C>A	c.(10-12)tcC>tcA	p.S4S	LGR5_ENST00000540815.2_Silent_p.S4S|TSPAN8_ENST00000393330.2_Intron|LGR5_ENST00000536515.1_Silent_p.S4S			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	4						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TGGACACCTCCCGGCTCGGTG	0.721000													4	47					0.00909568	0.00962342	1	1	0
CCDC170	80129	broad.mit.edu	37	6	151939253	151939253	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:151939253C>A	ENST00000367290.5	+	11	2229	c.2140C>A	c.(2140-2142)Cca>Aca	p.P714T	CCDC170_ENST00000239374.7_Missense_Mutation_p.P707T			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	707																	AGAGAGGCACCCACAAGGCCA	0.438000													14	76					0.00244969	0.00267396	1	1	0
AP1G1	164	broad.mit.edu	37	16	71780567	71780567	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:71780567C>A	ENST00000299980.4	-	17	2095	c.1654G>T	c.(1654-1656)Gga>Tga	p.G552*	AP1G1_ENST00000423132.2_Nonsense_Mutation_p.G555*|AP1G1_ENST00000393512.3_Nonsense_Mutation_p.G555*|AP1G1_ENST00000564155.1_5'UTR|AP1G1_ENST00000433195.2_Nonsense_Mutation_p.G575*|AP1G1_ENST00000569748.1_Nonsense_Mutation_p.G552*	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	552					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity	p.G552R(1)		breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				ATGCTGCTTCCGTAGATGGAA	0.353000													11	57					1.08611e-07	1.42667e-07	1	1	0
ZUFSP	221302	broad.mit.edu	37	6	116967063	116967063	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:116967063T>A	ENST00000368576.3	-	9	1746	c.1503A>T	c.(1501-1503)aaA>aaT	p.K501N		NM_145062.2	NP_659499.2	Q96AP4	ZUFSP_HUMAN	zinc finger with UFM1-specific peptidase domain	501						intracellular	zinc ion binding			NS(1)|endometrium(2)|kidney(6)|large_intestine(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	21				GBM - Glioblastoma multiforme(226;0.0258)|all cancers(137;0.0368)|OV - Ovarian serous cystadenocarcinoma(136;0.0464)|Epithelial(106;0.186)		TTCGGTTTTTTTTCTCTTCAA	0.338000													22	63					0	0	1	0	0
TTC30A	92104	broad.mit.edu	37	2	178482620	178482620	+	Silent	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:178482620A>T	ENST00000355689.4	-	1	1074	c.810T>A	c.(808-810)gcT>gcA	p.A270A	AC073834.3_ENST00000357045.4_RNA	NM_152275.3	NP_689488.3	Q86WT1	TT30A_HUMAN	tetratricopeptide repeat domain 30A	270					cell projection organization	cilium	binding			autonomic_ganglia(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(117;0.000423)|Epithelial(96;0.00373)|all cancers(119;0.0169)			GGGTTTCTTGAGCTACCTCAT	0.522000													45	187					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620879	7620879	+	Silent	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:7620879T>C	ENST00000486284.1	+	8	2560	c.2286T>C	c.(2284-2286)taT>taC	p.Y762Y	GRM7_ENST00000389336.4_Silent_p.Y762Y|GRM7_ENST00000402647.2_Silent_p.Y762Y|GRM7_ENST00000357716.4_Silent_p.Y762Y|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000403881.1_Silent_p.Y762Y	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	762					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CCTTGGGATATAGCATTCTTC	0.438000													17	105					0	0	1	0	0
POLQ	10721	broad.mit.edu	37	3	121204000	121204000	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:121204000A>T	ENST00000264233.5	-	17	5789	c.5661T>A	c.(5659-5661)gaT>gaA	p.D1887E		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1887					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		GAAATCCATCATCTCTAATAG	0.368000								DNA polymerases (catalytic subunits)					12	85					0	0	1	0	0
HAS2	3037	broad.mit.edu	37	8	122626810	122626810	+	Silent	SNP	G	G	T	rs148429340	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:122626810G>T	ENST00000303924.4	-	4	1735	c.1198C>A	c.(1198-1200)Cgg>Agg	p.R400R		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	400						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			ATTTTACCCCGGTAGAAGAGC	0.408000													28	166					5.61819e-17	8.774e-17	1	1	0
AQR	9716	broad.mit.edu	37	15	35163077	35163077	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:35163077C>A	ENST00000156471.5	-	31	3869	c.3644G>T	c.(3643-3645)tGt>tTt	p.C1215F		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	1215						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ACCAAGTAAACACATGTACAT	0.343000													7	83					0.0293803	0.0303092	1	1	0
GPR149	344758	broad.mit.edu	37	3	154146887	154146887	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:154146887C>A	ENST00000389740.2	-	1	617	c.518G>T	c.(517-519)gGc>gTc	p.G173V		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	173						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			CACGAAGGCGCCCCAGCCGCA	0.662000													7	47					0.248553	0.251802	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76513434	76513434	+	Splice_Site	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:76513434C>G	ENST00000307431.8	+	13	2263	c.1879_splice	c.e13+1	p.T626_splice	CNTNAP4_ENST00000476707.1_Splice_Site_p.T630_splice|CNTNAP4_ENST00000377504.4_Splice_Site_p.T578_splice|CNTNAP4_ENST00000478060.1_Splice_Site_p.T554_splice|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	627	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.T602T(1)|p.T554T(1)|p.T626T(1)		breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						GCAATATGACCGGTGAGTTAA	0.338000													22	107					0	0	1	0	0
CCDC107	203260	broad.mit.edu	37	9	35660488	35660488	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:35660488G>A	ENST00000421582.2	+	3	412	c.349G>A	c.(349-351)Ggg>Agg	p.G117R	CCDC107_ENST00000378409.3_Intron|ARHGEF39_ENST00000343259.3_3'UTR|CCDC107_ENST00000378406.1_Intron|CCDC107_ENST00000378407.3_Intron|ARHGEF39_ENST00000378395.2_3'UTR|CCDC107_ENST00000426546.2_Intron|ARHGEF39_ENST00000378387.3_3'UTR|CCDC107_ENST00000327351.2_Intron			Q8WV48	CC107_HUMAN	coiled-coil domain containing 107	269						integral to membrane				endometrium(1)|lung(3)|skin(1)	5	all_epithelial(49;0.217)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GTGCTGGGTCGGGGGAGTTTA	0.552000													20	77					0	0	1	0	0
SHOX2	6474	broad.mit.edu	37	3	157823829	157823829	+	Translation_Start_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:157823829G>T	ENST00000389589.4	-	0	120				RSRC1_ENST00000480820.1_Intron|SHOX2_ENST00000554685.1_5'UTR|SHOX2_ENST00000441443.2_De_novo_Start_OutOfFrame|SHOX2_ENST00000425436.3_De_novo_Start_OutOfFrame|SHOX2_ENST00000483851.2_De_novo_Start_OutOfFrame	NM_003030.4	NP_003021.3	O60902	SHOX2_HUMAN	short stature homeobox 2						nervous system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(10)|skin(3)|upper_aerodigestive_tract(1)	20			Lung(72;0.00318)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CCGCACGTCAGCCCGGCGCTC	0.542000													5	49					0.000602214	0.000671534	1	1	0
KRT76	51350	broad.mit.edu	37	12	53165928	53165928	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:53165928C>T	ENST00000332411.2	-	5	1140	c.1087G>A	c.(1087-1089)Gag>Aag	p.E363K		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	363	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TGGGCAATCTCCTCATACTGG	0.572000													10	96					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070965	9070965	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:9070965G>T	ENST00000397910.4	-	3	16684	c.16481C>A	c.(16480-16482)aCg>aAg	p.T5494K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5496	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTTCTCAGACGTGCTGCTCTC	0.473000													19	75					6.94344e-10	9.78394e-10	1	1	0
MLXIPL	51085	broad.mit.edu	37	7	73008232	73008232	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:73008232C>G	ENST00000313375.3	-	17	2569	c.2522G>C	c.(2521-2523)cGg>cCg	p.R841P	MLXIPL_ENST00000354613.1_Missense_Mutation_p.R820P|MLXIPL_ENST00000395189.1_Missense_Mutation_p.R748P|MLXIPL_ENST00000434326.1_3'UTR|MLXIPL_ENST00000414749.2_Missense_Mutation_p.R839P|MLXIPL_ENST00000429400.2_Missense_Mutation_p.R822P	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	841					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGTGACTGCCCGTGTGGCTTG	0.637000													10	61					0	0	1	0	0
APBB1	322	broad.mit.edu	37	11	6432502	6432502	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:6432502G>A	ENST00000389906.2	-	2	175	c.76C>T	c.(76-78)Ctg>Ttg	p.L26L	APBB1_ENST00000311051.3_Silent_p.L26L|APBB1_ENST00000299402.6_Silent_p.L26L|APBB1_ENST00000533407.1_Intron	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	26					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		TGCAGAGGCAGGGGTAGGCTC	0.652000													25	115					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372402	175372402	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:175372402C>A	ENST00000367674.1	-	4	1558	c.850G>T	c.(850-852)Gag>Tag	p.E284*	TNR_ENST00000263525.2_Nonsense_Mutation_p.E284*	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	284	Cys-rich.|EGF-like 4.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TAGCCCTCCTCGCATAAACAG	0.612000													21	54					3.51602e-12	5.1535e-12	1	1	0
CYLC1	1538	broad.mit.edu	37	X	83129330	83129330	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:83129330C>A	ENST00000329312.4	+	4	1651	c.1614C>A	c.(1612-1614)atC>atA	p.I538I		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	538	8 X approximate tandem repeats.				cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						CTACAAAAATCAAAGGTTCAG	0.363000													11	27					0.000151284	0.000174993	1	1	0
LRRC7	57554	broad.mit.edu	37	1	70452010	70452010	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:70452010A>G	ENST00000310961.5	+	11	1191	c.773A>G	c.(772-774)gAa>gGa	p.E258G	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.E253G			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	253						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TCTGGATGTGAAGCCCTTGAG	0.338000													6	49					0	0	1	0	0
CPXCR1	53336	broad.mit.edu	37	X	88009017	88009017	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:88009017G>T	ENST00000276127.4	+	3	861	c.602G>T	c.(601-603)aGg>aTg	p.R201M	CPXCR1_ENST00000373111.1_Missense_Mutation_p.R201M	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	201						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						AGGCCTTCGAGGGTGCACTAC	0.423000													7	22					1.06961e-07	1.41399e-07	1	1	0
DNAJB8	165721	broad.mit.edu	37	3	128181853	128181853	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:128181853G>T	ENST00000469083.1	-	2	2793	c.236C>A	c.(235-237)gCc>gAc	p.A79D	DNAJB8_ENST00000319153.3_Missense_Mutation_p.A79D			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	79					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		GGGCGTGCTGGCCCCGCCACC	0.592000													11	136					1.08611e-07	1.42667e-07	1	1	0
POC1A	25886	broad.mit.edu	37	3	52181101	52181101	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:52181101C>A	ENST00000394970.2	-	5	783	c.466G>T	c.(466-468)Gac>Tac	p.D156Y	POC1A_ENST00000474012.1_Missense_Mutation_p.D118Y|POC1A_ENST00000296484.2_Missense_Mutation_p.D156Y	NM_001161580.1	NP_001155052.1	Q8NBT0	POC1A_HUMAN	POC1 centriolar protein A	156						centriole|microtubule basal body				endometrium(1)|large_intestine(4)|liver(1)|lung(4)|prostate(3)|skin(1)	14						AGCCGCCCGTCGGGGGAGAAC	0.582000													8	52					1.26484e-09	1.76226e-09	1	1	0
MYOM2	9172	broad.mit.edu	37	8	2021570	2021570	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:2021570G>C	ENST00000262113.4	+	10	1251	c.1110G>C	c.(1108-1110)ctG>ctC	p.L370L	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	370	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GCGCCTTCCTGTTTGTCAGAG	0.667000													7	22					0	0	1	0	0
KCTD15	79047	broad.mit.edu	37	19	34297900	34297900	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:34297900G>T	ENST00000284006.5	+	5	627	c.375G>T	c.(373-375)ccG>ccT	p.P125P	KCTD15_ENST00000589786.1_Silent_p.P125P|KCTD15_ENST00000430256.2_Silent_p.P125P|KCTD15_ENST00000588881.1_Silent_p.P125P	NM_001129994.1|NM_001129995.1|NM_024076.2	NP_001123466.1|NP_001123467.1|NP_076981.2	Q96SI1	KCD15_HUMAN	potassium channel tetramerization domain containing 15	125	BTB.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(1)|lung(2)|pancreas(1)|urinary_tract(1)	5	Esophageal squamous(110;0.162)					TGCTGCTTCCGGATGACTTTA	0.537000													8	78					1.12685e-05	1.35924e-05	1	1	0
TCHH	7062	broad.mit.edu	37	1	152084594	152084594	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:152084594C>T	ENST00000368804.1	-	2	1098	c.1099G>A	c.(1099-1101)Gag>Aag	p.E367K		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	367	5 X 13 AA tandem repeats of R-R-E-Q-E-E- E-R-R-E-Q-Q-L.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			tcctcctgctcgcgcctcagc	0.721000													5	41					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78686810	78686810	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:78686810G>C	ENST00000545128.1	+	7	1428	c.890G>C	c.(889-891)aGa>aCa	p.R297T	PCSK5_ENST00000376767.3_Missense_Mutation_p.R297T|PCSK5_ENST00000376752.4_Missense_Mutation_p.R297T	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	297	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						AACGGCGTTAGAATGGTAGGT	0.517000													12	161					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130869662	130869662	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:130869662G>T	ENST00000357462.5	-	4	916	c.823C>A	c.(823-825)Cca>Aca	p.P275T	POTEF_ENST00000360967.5_Missense_Mutation_p.P275T|POTEF_ENST00000409914.2_Missense_Mutation_p.P275T|POTEF_ENST00000361163.4_Missense_Mutation_p.P285T			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	275						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						AGTAACAGTGGTGTGAGGCCA	0.323000													9	64					0.000442599	0.00049893	1	1	0
MFSD10	10227	broad.mit.edu	37	4	2934858	2934858	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:2934858C>T	ENST00000329687.4	-	3	881	c.347G>A	c.(346-348)aGg>aAg	p.R116K	MFSD10_ENST00000507555.1_Missense_Mutation_p.R116K|MFSD10_ENST00000514800.1_Missense_Mutation_p.R116K|MFSD10_ENST00000355443.4_Missense_Mutation_p.R116K|MFSD10_ENST00000508221.1_Missense_Mutation_p.R116K	NM_001120.4	NP_001111.3	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing 10	116					apoptosis	integral to membrane	tetracycline transporter activity			breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|skin(1)	7				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CACCGGGCGCCTCCCCAAGCA	0.627000													3	33					0	0	1	0	0
ALG11	440138	broad.mit.edu	37	13	52598366	52598366	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:52598366G>T	ENST00000521508.1	+	3	505	c.500G>T	c.(499-501)tGt>tTt	p.C167F	ALG11_ENST00000523764.1_Intron|ALG11_ENST00000519151.1_3'UTR	NM_001004127.2	NP_001004127.2			ALG11, alpha-1,2-mannosyltransferase											endometrium(1)|large_intestine(6)|lung(4)|ovary(2)	13		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.44e-08)		CTAATGCAGTGTGTTCCTGAT	0.428000													15	133					1.3612e-06	1.72234e-06	1	1	0
TERT	7015	broad.mit.edu	37	5	1264599	1264599	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:1264599C>G	ENST00000310581.5	-	11	2820	c.2763G>C	c.(2761-2763)caG>caC	p.Q921H	TERT_ENST00000334602.6_Intron|TERT_ENST00000296820.5_3'UTR	NM_001193376.1|NM_198253.2	NP_001180305.1|NP_937983.2	O14746	TERT_HUMAN	telomerase reverse transcriptase	921	Required for oligomerization.|Reverse transcriptase.				anti-apoptosis|DNA strand elongation|replicative senescence|telomere formation via telomerase|telomere maintenance via telomerase	cytoplasm|nucleolus|PML body|telomerase holoenzyme complex	protein homodimerization activity|telomeric DNA binding|telomeric RNA binding|telomeric template RNA reverse transcriptase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(3)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	41	all_cancers(3;3.17e-16)|Lung NSC(6;8.55e-15)|all_lung(6;7.2e-14)|all_epithelial(6;1.87e-10)		Epithelial(17;0.00105)|all cancers(22;0.00178)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			GGGCCGGCATCTGAACAAAAG	0.627000									TERT Mutation-Associated Haematological Disorders;Pulmonary Fibrosis, Idiopathic;Congenital Dyskeratosis				4	60					0	0	1	0	0
ATF2	1386	broad.mit.edu	37	2	175979528	175979528	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:175979528G>A	ENST00000264110.2	-	8	814	c.516C>T	c.(514-516)ccC>ccT	p.P172P	ATF2_ENST00000392543.2_Intron|ATF2_ENST00000538946.1_Silent_p.P154P|ATF2_ENST00000409437.1_Intron|ATF2_ENST00000487334.2_Silent_p.P154P|ATF2_ENST00000345739.5_Silent_p.P114P|ATF2_ENST00000426833.3_Silent_p.P154P|ATF2_ENST00000409833.1_Silent_p.P172P|ATF2_ENST00000409635.1_Silent_p.P114P|ATF2_ENST00000409499.1_Intron|ATF2_ENST00000392544.1_Silent_p.P172P	NM_001256090.1|NM_001256091.1|NM_001880.3	NP_001243019.1|NP_001243020.1|NP_001871.2	P15336	ATF2_HUMAN	activating transcription factor 2	172					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	protein dimerization activity|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)	17			OV - Ovarian serous cystadenocarcinoma(117;0.125)			GCAGCACATTGGGAACCTGTA	0.438000													30	148					0	0	1	0	0
IL9R	3581	broad.mit.edu	37	X	155231146	155231146	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:155231146C>G	ENST00000540897.1	+	2	156	c.88C>G	c.(88-90)Cag>Gag	p.Q30E	IL9R_ENST00000244174.5_Intron|IL9R_ENST00000424344.3_5'UTR|IL9R_ENST00000369423.2_Missense_Mutation_p.Q40E	NM_176786.1	NP_789743.2	Q01113	IL9R_HUMAN	interleukin 9 receptor	0					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CTGGTGGTTCCAGGCTGCACG	0.557000													22	268					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16399487	16399487	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:16399487G>A	ENST00000334133.4	-	7	1370	c.1098C>T	c.(1096-1098)acC>acT	p.T366T	RFTN1_ENST00000483671.1_5'UTR|RFTN1_ENST00000432519.1_Silent_p.T330T	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	366						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						AGCCCTGTATGGTTTTGCTAT	0.463000													12	138					0	0	1	0	0
SLC12A3	6559	broad.mit.edu	37	16	56903738	56903738	+	Splice_Site	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:56903738T>A	ENST00000438926.2	+	4	630		c.e4+2		SLC12A3_ENST00000563236.1_Splice_Site|SLC12A3_ENST00000566786.1_Splice_Site|SLC12A3_ENST00000262502.5_Splice_Site	NM_000339.2|NM_001126107.1|NM_001126108.1	NP_000330.2|NP_001119579.1|NP_001119580.1	P55017	S12A3_HUMAN	solute carrier family 12 (sodium/chloride transporter), member 3						sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(28)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	TCAAGTCAGGTGGGCCATCCC	0.597000													4	49					0	0	1	0	0
FAM86HP	729375	broad.mit.edu	37	3	129821650	129821650	+	RNA	SNP	G	G	A	rs56088005	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:129821650G>A	ENST00000500074.2	-	0	495																											GGTTGCGGACGGTAAAGGCCA	0.667000													6	112					0	0	1	0	0
HIST1H4E	8367	broad.mit.edu	37	6	26204924	26204924	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:26204924C>G	ENST00000360441.4	+	1	67	c.52C>G	c.(52-54)Cgt>Ggt	p.R18G		NM_003545.3	NP_003536.1	P62805	H4_HUMAN	histone cluster 1, H4e	18					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(2)	18		all_hematologic(11;0.196)				AGGCGCTAAGCGTCACCGTAA	0.552000													28	90					0	0	1	0	0
PASD1	139135	broad.mit.edu	37	X	150780189	150780189	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:150780189G>C	ENST00000370357.4	+	4	416	c.171G>C	c.(169-171)gtG>gtC	p.V57V		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	57	PAS.					nucleus	signal transducer activity			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					TCATTTGTGTGGCTGAAAACA	0.333000													18	64					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58240827	58240827	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:58240827G>T	ENST00000377918.3	+	3	2683	c.2657G>T	c.(2656-2658)aGc>aTc	p.S886I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	886					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GAAAGAGCCAGCCTGAGAGAC	0.463000													9	58					0.00448238	0.00483318	1	1	0
SEMG2	6407	broad.mit.edu	37	20	43850823	43850823	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:43850823G>T	ENST00000372769.3	+	2	640	c.550G>T	c.(550-552)Ggt>Tgt	p.G184C		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	184	Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				TGCACAAAAAGGTAGAACACA	0.378000													16	104					4.14922e-12	6.06725e-12	1	1	0
SETX	23064	broad.mit.edu	37	9	135163991	135163991	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:135163991T>C	ENST00000372169.2	-	16	6336	c.6154A>G	c.(6154-6156)Att>Gtt	p.I2052V	SETX_ENST00000224140.5_Missense_Mutation_p.I2052V|SETX_ENST00000393220.1_Missense_Mutation_p.I2052V			Q7Z333	SETX_HUMAN	senataxin	2052					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCACTATTAATAGACTTTTCT	0.358000													5	34					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94546095	94546095	+	Missense_Mutation	SNP	C	C	A	rs63749083		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:94546095C>A	ENST00000370225.3	-	8	1124	c.1038G>T	c.(1036-1038)aaG>aaT	p.K346N	ABCA4_ENST00000535735.1_Missense_Mutation_p.K346N	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	346					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCAGAAAGGCCTTATAGTTAT	0.473000													18	120					6.33239e-15	9.69402e-15	1	1	0
ARFGAP1	55738	broad.mit.edu	37	20	61919105	61919105	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:61919105G>T	ENST00000370283.4	+	13	1241	c.1101G>T	c.(1099-1101)tgG>tgT	p.W367C	ARFGAP1_ENST00000518794.2_3'UTR|ARFGAP1_ENST00000519273.2_Missense_Mutation_p.W254C|ARFGAP1_ENST00000370275.4_3'UTR|ARFGAP1_ENST00000353546.3_Missense_Mutation_p.W375C|ARFGAP1_ENST00000519604.1_Missense_Mutation_p.W322C|ARFGAP1_ENST00000547204.1_Missense_Mutation_p.W301C	NM_018209.2	NP_060679.1	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	367					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					GGGAGGTGTGGGGCTCGGCCT	0.692000													6	17					0.00116845	0.00128674	1	1	0
TPM2	7169	broad.mit.edu	37	9	35685460	35685460	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:35685460C>G	ENST00000378292.3	-	4	1665	c.463G>C	c.(463-465)Gct>Cct	p.A155P	TPM2_ENST00000378300.5_Missense_Mutation_p.A155P|TPM2_ENST00000360958.2_Missense_Mutation_p.A155P|TPM2_ENST00000329305.2_Missense_Mutation_p.A155P	NM_213674.1	NP_998839.1	P07951	TPM2_HUMAN	tropomyosin 2 (beta)	155					muscle filament sliding|regulation of ATPase activity	cytosol|muscle thin filament tropomyosin	actin binding|structural constituent of muscle			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_epithelial(49;0.121)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GAATCCTCAGCGATGTGCTTG	0.552000													16	96					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71592748	71592748	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:71592748C>G	ENST00000409544.1	+	6	2537	c.1907C>G	c.(1906-1908)tCt>tGt	p.S636C	ZNF638_ENST00000264447.4_Missense_Mutation_p.S636C|ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000377802.2_Missense_Mutation_p.S636C|ZNF638_ENST00000355812.3_Missense_Mutation_p.S636C	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	636					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						GGAGGACATTCTATTCGTTGT	0.378000													7	57					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61687968	61687968	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:61687968T>G	ENST00000577390.1	-	12	2898	c.1944A>C	c.(1942-1944)aaA>aaC	p.K648N	CDH8_ENST00000299345.6_Missense_Mutation_p.K648N|CDH8_ENST00000577730.1_Missense_Mutation_p.K648N	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	648				K -> QK (in Ref. 4; AAA35628).	adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ATGGTTCATTTTTATGCCGCC	0.398000													10	95					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60892525	60892525	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:60892525C>A	ENST00000252999.3	-	55	7453	c.7387G>T	c.(7387-7389)Ggg>Tgg	p.G2463W		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2463	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCCGAGCCCCATCCAGGCTG	0.677000													7	32					2.62144e-13	3.91637e-13	1	1	0
AKAP3	10566	broad.mit.edu	37	12	4737400	4737400	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:4737400C>T	ENST00000545990.2	-	5	1192	c.668G>A	c.(667-669)aGc>aAc	p.S223N	AKAP3_ENST00000228850.1_Missense_Mutation_p.S223N	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	223					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						TTCTTTGGTGCTCTCCTTGAT	0.463000													8	158					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94486794	94486794	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:94486794G>T	ENST00000375708.3	-	9	2180	c.1982C>A	c.(1981-1983)cCa>cAa	p.P661Q	ROR2_ENST00000375715.1_Missense_Mutation_p.P521Q|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	661	Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GATGGCCTCTGGGGCCATCCA	0.582000													6	42					0.0215528	0.0223084	1	1	0
CD1C	911	broad.mit.edu	37	1	158261143	158261143	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:158261143G>C	ENST00000368170.3	+	2	560	c.281G>C	c.(280-282)gGa>gCa	p.G94A		NM_001765.2	NP_001756.2	P29017	CD1C_HUMAN	CD1c molecule	94					antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			NS(1)|endometrium(3)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	39	all_hematologic(112;0.0378)					TACCTCTTTGGATTAACTCGG	0.383000													27	106					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28934766	28934766	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:28934766C>A	ENST00000257192.4	+	15	2819	c.2607C>A	c.(2605-2607)gtC>gtA	p.V869V	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG1_ENST00000462981.2_Silent_p.V228V|RP11-534N16.1_ENST00000581452.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	869					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGAGAGTGGTCGGCCCAATCT	0.507000													36	136					6.02846e-25	9.65799e-25	1	1	0
DPH2	1802	broad.mit.edu	37	1	44437368	44437368	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:44437368G>C	ENST00000255108.3	+	4	966	c.794G>C	c.(793-795)gGa>gCa	p.G265A	DPH2_ENST00000529729.1_3'UTR|DPH2_ENST00000396758.2_Intron|DPH2_ENST00000412950.2_Missense_Mutation_p.G130A	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	265					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				GCCCGGGCTGGACGGCTAAGG	0.627000													5	85					0	0	1	0	0
OR14C36	127066	broad.mit.edu	37	1	248513002	248513002	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:248513002C>A	ENST00000317861.1	+	1	926	c.926C>A	c.(925-927)tCa>tAa	p.S309*		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						ATTTTTTATTCAGAAAATGTG	0.328000													17	91					0.00400662	0.00433527	1	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160274785	160274785	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:160274785G>C	ENST00000264431.4	+	22	4174	c.3755G>C	c.(3754-3756)tGc>tCc	p.C1252S		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1252					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		TGGACGTCATGCTCAAGTGGC	0.517000													12	136					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410054	159410054	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:159410054C>T	ENST00000423932.3	+	1	543	c.506C>T	c.(505-507)aCg>aTg	p.T169M	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	169					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					GTAGCAATAACGCAAGTGACA	0.507000													64	185					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	439300	439300	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:439300C>G	ENST00000432829.2	+	40	5247	c.4931C>G	c.(4930-4932)cCt>cGt	p.P1644R	DOCK8_ENST00000453981.1_Missense_Mutation_p.P1712R|DOCK8_ENST00000469391.1_Missense_Mutation_p.P1612R|DOCK8_ENST00000382329.1_Missense_Mutation_p.P1179R	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1712	DHR-2.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		ACCCTGTCACCTGACGAGGAT	0.587000													13	87					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70488292	70488292	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:70488292G>T	ENST00000260128.4	+	6	977	c.260G>T	c.(259-261)tGc>tTc	p.C87F	SULF1_ENST00000458141.2_Missense_Mutation_p.C87F|SULF1_ENST00000402687.4_Missense_Mutation_p.C87F|SULF1_ENST00000419716.3_Missense_Mutation_p.C87F	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	87					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ACACCCATGTGCTGCCCGTCA	0.532000													8	54					0.00307968	0.00335571	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66467710	66467710	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:66467710C>G	ENST00000273854.3	-	3	1159	c.559G>C	c.(559-561)Gat>Cat	p.D187H	EPHA5_ENST00000432638.2_Missense_Mutation_p.D187H|EPHA5_ENST00000511294.1_Missense_Mutation_p.D187H|EPHA5_ENST00000354839.4_Missense_Mutation_p.D187H	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	187					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TCACCAAGATCAAGTTCTGTA	0.383000										TSP Lung(17;0.13)			13	148					0	0	1	0	0
WNT16	51384	broad.mit.edu	37	7	120969705	120969705	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:120969705C>A	ENST00000222462.2	+	2	470	c.180C>A	c.(178-180)tgC>tgA	p.C60*	WNT16_ENST00000361301.2_Nonsense_Mutation_p.C50*	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	60					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					AGGAGCTGTGCAAGAGGAAAC	0.617000													18	94					2.4624e-09	3.38511e-09	1	1	0
MON2	23041	broad.mit.edu	37	12	62936895	62936895	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:62936895G>T	ENST00000393630.3	+	20	2774	c.2383G>T	c.(2383-2385)Gtt>Ttt	p.V795F	MON2_ENST00000546600.1_Missense_Mutation_p.V795F|MON2_ENST00000393632.2_Missense_Mutation_p.V795F|MON2_ENST00000552115.1_Missense_Mutation_p.V795F|MON2_ENST00000393629.2_Missense_Mutation_p.V795F|MON2_ENST00000552738.1_Missense_Mutation_p.V772F|MON2_ENST00000280379.6_Missense_Mutation_p.V795F	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	795					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		TCTTTTTGCTGTTGCCAAATT	0.343000													5	64					0.217242	0.221166	1	1	0
WDR62	284403	broad.mit.edu	37	19	36564398	36564398	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:36564398G>A	ENST00000401500.2	+	9	1233	c.1198G>A	c.(1198-1200)Gag>Aag	p.E400K	WDR62_ENST00000388999.3_Missense_Mutation_p.E400K|WDR62_ENST00000270301.7_Missense_Mutation_p.E400K|WDR62_ENST00000378860.4_3'UTR	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	400					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGTGTGGTCAGAGCTCTTCCA	0.587000													18	89					0	0	1	0	0
CMPK2	129607	broad.mit.edu	37	2	6991649	6991649	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:6991649C>T	ENST00000256722.5	-	4	1157	c.1158G>A	c.(1156-1158)ctG>ctA	p.L386L	CMPK2_ENST00000458098.1_Intron|CMPK2_ENST00000478738.1_5'UTR|CMPK2_ENST00000404168.1_Silent_p.L386L	NM_207315.3	NP_997198.2	Q5EBM0	CMPK2_HUMAN	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	386					dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity			large_intestine(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCCGGCCCTGCAGCCTCTGCA	0.572000													9	79					0	0	1	0	0
GDA	9615	broad.mit.edu	37	9	74838075	74838075	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:74838075C>T	ENST00000358399.3	+	7	739	c.646C>T	c.(646-648)Ctc>Ttc	p.L216F	GDA_ENST00000376989.3_Intron|GDA_ENST00000238018.4_Missense_Mutation_p.L216F|GDA_ENST00000477618.1_3'UTR|GDA_ENST00000376986.1_Intron|GDA_ENST00000545168.1_Missense_Mutation_p.L142F	NM_001242505.2|NM_001242506.2|NM_004293.4	NP_001229434.1|NP_001229435.1|NP_004284.1	Q9Y2T3	GUAD_HUMAN	guanine deaminase	216					nervous system development|purine base metabolic process|purine nucleotide catabolic process	cytosol	guanine deaminase activity|zinc ion binding			central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(20)|ovary(2)|skin(2)|urinary_tract(1)	32		Myeloproliferative disorder(762;0.0122)		Lung(182;0.0583)		ACGTTTTTCCCTCTCCTGCTC	0.393000													12	67					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89448526	89448526	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:89448526G>T	ENST00000336596.2	+	7	1715	c.1490G>T	c.(1489-1491)aGt>aTt	p.S497I	EPHA3_ENST00000494014.1_Missense_Mutation_p.S497I|EPHA3_ENST00000452448.2_Missense_Mutation_p.S497I	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	497	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTTACCATCAGTAGCCTCAAG	0.418000										TSP Lung(6;0.00050)			11	67					0.000673444	0.000749615	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20618587	20618587	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:20618587G>T	ENST00000504154.1	+	35	4154	c.3902G>T	c.(3901-3903)gGa>gTa	p.G1301V	SLIT2_ENST00000503823.1_Missense_Mutation_p.G1293V|SLIT2_ENST00000503837.1_Missense_Mutation_p.G1297V|SLIT2_ENST00000273739.5_Missense_Mutation_p.G1314V	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1301	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GGGCAGAACGGAACCAGCTTC	0.582000													9	73					6.40141e-05	7.51681e-05	1	1	0
TGM6	343641	broad.mit.edu	37	20	2380966	2380966	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:2380966G>A	ENST00000202625.2	+	7	926	c.865G>A	c.(865-867)Ggg>Agg	p.G289R	TGM6_ENST00000477505.1_3'UTR|TGM6_ENST00000381423.1_Missense_Mutation_p.G289R	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	289					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CAGGTGCTTGGGGATAGCCAC	0.627000													11	80					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47408399	47408399	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:47408399C>A	ENST00000398879.1	-	17	2210	c.1844G>T	c.(1843-1845)tGc>tTc	p.C615F	TNS3_ENST00000355730.3_Missense_Mutation_p.C375F|TNS3_ENST00000311160.9_Missense_Mutation_p.C615F			Q68CZ2	TENS3_HUMAN	tensin 3	615						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						GTCTGCAGGGCAGCGGCTCAC	0.657000													11	100					1.58986e-06	2.00349e-06	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10466744	10466744	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:10466744G>A	ENST00000382483.3	-	4	5087	c.4864C>T	c.(4864-4866)Cgg>Tgg	p.R1622W		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1622					intracellular signal transduction			p.R1622W(1)		breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCCAGGGTCCGCTCAGAGAAG	0.716000													3	29					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49060478	49060478	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:49060478T>G	ENST00000380950.2	-	15	2143	c.1956A>C	c.(1954-1956)ttA>ttC	p.L652F	CEP152_ENST00000325747.5_Missense_Mutation_p.L559F|CEP152_ENST00000399334.3_Missense_Mutation_p.L652F	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	652					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		TTTGATTACATAAGTCTTGAT	0.343000													4	34					0	0	1	0	0
HSPA1L	3305	broad.mit.edu	37	6	31778377	31778377	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:31778377A>T	ENST00000375654.4	-	2	1562	c.1373T>A	c.(1372-1374)cTg>cAg	p.L458Q	HSPA1L_ENST00000417199.3_Missense_Mutation_p.L458Q	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	458					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						AAACCGCCCCAGCAGGTTGTT	0.532000													50	124					0	0	1	0	0
SIRPD	128646	broad.mit.edu	37	20	1538295	1538295	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:1538295G>A	ENST00000381623.3	-	1	1194	c.5C>T	c.(4-6)cCc>cTc	p.P2L	RP4-576H24.4_ENST00000564763.1_Intron|SIRPD_ENST00000381621.1_Missense_Mutation_p.P2L			Q9H106	SIRPD_HUMAN	signal-regulatory protein delta	2						extracellular region				breast(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)	15						GGCAGGGATGGGCATTGTGGT	0.577000													8	90					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63019331	63019331	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:63019331G>T	ENST00000561311.1	+	27	3531	c.3301G>T	c.(3301-3303)Ggc>Tgc	p.G1101C	TLN2_ENST00000306829.6_Missense_Mutation_p.G1101C			Q9Y4G6	TLN2_HUMAN	talin 2	1101	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						CAAGGCGGTGGGCTCCTCCAT	0.542000													5	47					0.248553	0.251802	1	1	0
COLEC11	78989	broad.mit.edu	37	2	3652038	3652038	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:3652038G>T	ENST00000236693.7	+	2	254	c.20G>T	c.(19-21)aGa>aTa	p.R7I	COLEC11_ENST00000418971.2_Missense_Mutation_p.Q50H|COLEC11_ENST00000382062.2_Missense_Mutation_p.Q36H|COLEC11_ENST00000349077.4_Missense_Mutation_p.Q36H|COLEC11_ENST00000487365.1_3'UTR	NM_199235.2	NP_954705.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	0						collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		GCTCTGTGCAGATCCTCGTCC	0.632000													13	106					7.93312e-07	1.0079e-06	1	1	0
ADCY8	114	broad.mit.edu	37	8	131964215	131964215	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:131964215C>A	ENST00000286355.5	-	3	3232	c.1140G>T	c.(1138-1140)cgG>cgT	p.R380R	ADCY8_ENST00000377928.3_Silent_p.R380R	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	380					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GGACAACAAACCGGGGGAGCA	0.542000										HNSCC(32;0.087)			7	79					2.0095e-06	2.51187e-06	1	1	0
MS4A4A	51338	broad.mit.edu	37	11	60075608	60075608	+	Missense_Mutation	SNP	A	A	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:60075608A>C	ENST00000355131.3	+	8	843	c.620A>C	c.(619-621)cAc>cCc	p.H207P	MS4A4A_ENST00000395016.3_Missense_Mutation_p.H207P|MS4A4A_ENST00000532114.1_Missense_Mutation_p.H173P|MS4A4A_ENST00000337908.4_Missense_Mutation_p.H226P	NM_024021.3	NP_076926.2	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member 4A	226						integral to membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(12)|prostate(1)|skin(4)	23						TCACATTCTCACATGGCAGAA	0.453000													8	88					0	0	1	0	0
RGS1	5996	broad.mit.edu	37	1	192547379	192547379	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:192547379T>A	ENST00000367459.3	+	4	374	c.308T>A	c.(307-309)cTa>cAa	p.L103Q	RGS1_ENST00000469578.2_Missense_Mutation_p.L103Q	NM_002922.3	NP_002913.3	Q08116	RGS1_HUMAN	regulator of G-protein signaling 1	103	RGS.				immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|negative regulation of signal transduction	cytoplasm|plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			kidney(8)|large_intestine(1)|lung(13)	22		Breast(1374;0.188)				GGAAGTTTCCTAAAGTCTGAA	0.368000													15	159					0	0	1	0	0
OR7D4	125958	broad.mit.edu	37	19	9324816	9324816	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:9324816C>A	ENST00000308682.2	-	1	726	c.698G>T	c.(697-699)gGc>gTc	p.G233V		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						TTTGTACTTGCCCTTGGTGGA	0.512000													13	63					0.00010058	0.000116997	1	1	0
SZT2	23334	broad.mit.edu	37	1	43906967	43906967	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:43906967G>T	ENST00000562955.1	+	52	7256	c.7256G>T	c.(7255-7257)cGg>cTg	p.R2419L	SZT2_ENST00000372442.1_Missense_Mutation_p.R1577L	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	2476						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						ACTCGGGGCCGGAGGCGTCAC	0.557000													13	137					9.31168e-06	1.12759e-05	1	1	0
DMD	1756	broad.mit.edu	37	X	32404497	32404497	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:32404497G>A	ENST00000357033.4	-	33	4810	c.4604C>T	c.(4603-4605)aCg>aTg	p.T1535M	DMD_ENST00000378677.2_Missense_Mutation_p.T1531M	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1535	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGGATTTTCCGTCTGCTTTTT	0.383000													15	69					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36050797	36050797	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:36050797C>T	ENST00000262623.3	-	7	994	c.966G>A	c.(964-966)atG>atA	p.M322I		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	322					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCCAATGCACATGGCCACAA	0.552000													9	83					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037419	75037419	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:75037419G>T	ENST00000326665.5	-	14	4193	c.3975C>A	c.(3973-3975)aaC>aaA	p.N1325K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1325	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCTTTTGTGTGTTTCCTTCTC	0.562000													19	113					1.01871e-10	1.4757e-10	1	1	0
RASA1	5921	broad.mit.edu	37	5	86670002	86670002	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:86670002T>A	ENST00000456692.2	+	14	1383	c.1268T>A	c.(1267-1269)aTt>aAt	p.I423N	RASA1_ENST00000274376.6_Missense_Mutation_p.I600N|RASA1_ENST00000512763.1_Missense_Mutation_p.I433N|RASA1_ENST00000506290.1_Missense_Mutation_p.I434N	NM_022650.2	NP_072179.1	P20936	RASA1_HUMAN	RAS p21 protein activator (GTPase activating protein) 1	600	SH2 2.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			NS(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(12)|lung(13)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	48		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		GTTTTACATATTGAAGAAGCC	0.318000													3	16					0	0	1	0	0
OR4D10	390197	broad.mit.edu	37	11	59245789	59245789	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:59245789C>G	ENST00000530162.1	+	1	944	c.887C>G	c.(886-888)tCa>tGa	p.S296*		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S294*(1)|p.S296*(1)		NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAGATGAAGTCAGCCATGAGG	0.428000													5	87					0	0	1	0	0
TRAV21	28662	broad.mit.edu	37	14	22521191	22521191	+	RNA	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:22521191C>A	ENST00000390449.3	+	0	219																											CTTATTCAGTCAAGTCAGAGA	0.453000													9	37					0.000274275	0.000310879	1	1	0
AMER1	139285	broad.mit.edu	37	X	63410734	63410734	+	Silent	SNP	G	G	T	rs146952698	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:63410734G>T	ENST00000330258.3	-	2	2705	c.2433C>A	c.(2431-2433)atC>atA	p.I811I	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									CCACATCAGCGATGTCAAAGG	0.517000													9	16					1.12685e-05	1.35924e-05	1	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													4	56					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197408055	197408055	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:197408055A>G	ENST00000273582.5	-	17	2785	c.2240T>C	c.(2239-2241)gTg>gCg	p.V747A	KIAA0226_ENST00000296343.5_Missense_Mutation_p.V792A|KIAA0226_ENST00000389665.5_Missense_Mutation_p.V817A	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	792					autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		TATGTCCTGCACGTTGAAGAG	0.512000													17	104					0	0	1	0	0
EXPH5	23086	broad.mit.edu	37	11	108380319	108380319	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:108380319G>T	ENST00000265843.4	-	6	6025	c.5915C>A	c.(5914-5916)aCa>aAa	p.T1972K	EXPH5_ENST00000428840.1_Missense_Mutation_p.T1896K|EXPH5_ENST00000443411.1_Missense_Mutation_p.T1784K|EXPH5_ENST00000525344.1_Missense_Mutation_p.T1965K	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1972					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		ATCTGTGGTTGTGTCTGTGTC	0.393000													26	186					1.75199e-13	2.6429e-13	1	1	0
MAST1	22983	broad.mit.edu	37	19	12949441	12949441	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:12949441G>A	ENST00000251472.4	+	1	94	c.55G>A	c.(55-57)Ggc>Agc	p.G19S	MAST1_ENST00000591495.1_Intron	NM_014975.2	NP_055790.1	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase 1	19					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|lung(20)|ovary(5)|prostate(5)|skin(3)	56						CTCCTTCCCCGGCGGCAGTAT	0.662000													3	33					0	0	1	0	0
TTBK1	84630	broad.mit.edu	37	6	43214425	43214425	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:43214425G>A	ENST00000259750.4	+	2	110	c.27G>A	c.(25-27)aaG>aaA	p.K9K		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	9						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCGCCCTTAAGGACGAAACCA	0.672000													11	29					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515704	51515704	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:51515704G>C	ENST00000328188.1	+	1	423	c.423G>C	c.(421-423)ctG>ctC	p.L141L		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						TGTGTGCCCTGCTAATGGGAG	0.473000													29	144					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117130723	117130723	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:117130723G>C	ENST00000310357.3	-	2	273	c.252C>G	c.(250-252)atC>atG	p.I84M	GPRC6A_ENST00000530250.1_Missense_Mutation_p.I84M|GPRC6A_ENST00000368549.3_Missense_Mutation_p.I84M	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	84					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TTGAATTGTTGATCATCTCAA	0.378000													29	65					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771665	143771665	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:143771665C>A	ENST00000408898.2	+	1	391	c.353C>A	c.(352-354)tCc>tAc	p.S118Y		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GTGGTGATGTCCTATGATCGG	0.488000													24	132					1.10923e-09	1.55242e-09	1	1	0
MRPS30	10884	broad.mit.edu	37	5	44809472	44809472	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:44809472G>C	ENST00000507110.1	+	1	446	c.408G>C	c.(406-408)gcG>gcC	p.A136A		NM_016640.3	NP_057724.2	Q9NP92	RT30_HUMAN	mitochondrial ribosomal protein S30	136					apoptosis|translation	mitochondrion|ribosome	structural constituent of ribosome			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(11)|prostate(1)	20	Lung NSC(6;8.08e-07)					ctgaaccTGCGCTGGACCTCG	0.701000													4	19					0	0	1	0	0
RAB3GAP1	22930	broad.mit.edu	37	2	135870742	135870742	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:135870742G>T	ENST00000264158.8	+	6	427	c.384G>T	c.(382-384)gtG>gtT	p.V128V	RAB3GAP1_ENST00000539493.1_Silent_p.V84V|RAB3GAP1_ENST00000487003.1_3'UTR|RAB3GAP1_ENST00000442034.1_Silent_p.V128V	NM_012233.2	NP_036365.1	Q15042	RB3GP_HUMAN	RAB3 GTPase activating protein subunit 1 (catalytic)	128						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(10)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32				BRCA - Breast invasive adenocarcinoma(221;0.117)		GTGAGTTCGTGGTGATTGCCC	0.423000													16	106					1.99824e-07	2.59729e-07	1	1	0
ANKRD54	129138	broad.mit.edu	37	22	38229018	38229018	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr22:38229018G>C	ENST00000215941.4	-	6	859	c.667C>G	c.(667-669)Ctg>Gtg	p.L223V	ANKRD54_ENST00000406423.1_Missense_Mutation_p.L103V|ANKRD54_ENST00000498417.1_5'UTR|ANKRD54_ENST00000411961.2_Missense_Mutation_p.L207V	NM_138797.2	NP_620152.1	Q6NXT1	ANR54_HUMAN	ankyrin repeat domain 54	223										lung(1)	1	Melanoma(58;0.045)					CCCTCCTGCAGGATATTCAGC	0.617000													5	44					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5744483	5744483	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:5744483C>T	ENST00000546188.1	-	17	1725	c.1654G>A	c.(1654-1656)Gtg>Atg	p.V552M	ANO2_ENST00000538154.1_5'UTR|ANO2_ENST00000327087.8_Missense_Mutation_p.V551M|ANO2_ENST00000356134.5_Missense_Mutation_p.V552M			Q9NQ90	ANO2_HUMAN	anoctamin 2	556						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TACACTATCACCCCAAAGACG	0.478000													8	40					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202462243	202462243	+	Splice_Site	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:202462243G>C	ENST00000406302.3	+	15	2096	c.1941_splice	c.e15-1	p.G648_splice	PPP1R12B_ENST00000290419.5_3'UTR|PPP1R12B_ENST00000336894.4_Splice_Site_p.G648_splice|PPP1R12B_ENST00000367270.4_5'UTR|PPP1R12B_ENST00000391959.3_5'UTR	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	648					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			TTTTCCCAGGGTGTCACCCTA	0.463000													33	109					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563352	55563352	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:55563352C>A	ENST00000335605.1	+	1	321	c.321C>A	c.(319-321)tgC>tgA	p.C107*		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TCCTGTCCTGCACTGCTGTGG	0.478000													13	53					2.27111e-07	2.94579e-07	1	1	0
MAML3	55534	broad.mit.edu	37	4	140811464	140811464	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:140811464C>A	ENST00000509479.2	-	2	1982	c.1126G>T	c.(1126-1128)Gcg>Tcg	p.A376S	MAML3_ENST00000327122.5_Missense_Mutation_p.A220S	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	376					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					GAAGGCCTCGCCTGGGGAGAT	0.592000													7	97					1.06961e-07	1.41399e-07	1	1	0
TAF3	83860	broad.mit.edu	37	10	8007705	8007705	+	Splice_Site	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:8007705A>T	ENST00000344293.5	+	3	2438	c.2232_splice	c.e3+1	p.K744_splice		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	744	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						AGCATGAAAAAGTAAGCAGTT	0.393000													6	69					0	0	1	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595934	140595934	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:140595934C>G	ENST00000341948.4	+	1	2426	c.2239C>G	c.(2239-2241)Cag>Gag	p.Q747E		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		747					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GACCCTATCCCAGAGCTACCA	0.622000													12	151					0	0	1	0	0
KLHL36	79786	broad.mit.edu	37	16	84690870	84690870	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:84690870G>T	ENST00000564996.1	+	3	598	c.457G>T	c.(457-459)Gag>Tag	p.E153*	KLHL36_ENST00000258157.5_Nonsense_Mutation_p.E153*	NM_024731.2	NP_079007.2	Q8N4N3	KLH36_HUMAN	kelch-like family member 36	153	BACK.									endometrium(3)|large_intestine(1)|lung(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						GTACCTGCAGGAGCTGGCCTC	0.582000													20	85					4.96729e-08	6.63733e-08	1	1	0
ADCY2	108	broad.mit.edu	37	5	7712986	7712986	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:7712986G>C	ENST00000338316.4	+	11	1685	c.1596G>C	c.(1594-1596)caG>caC	p.Q532H	ADCY2_ENST00000537121.1_Missense_Mutation_p.Q352H|RP11-711G10.1_ENST00000514105.2_RNA	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	532					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						CCATGGGTCAGCATAATTTTC	0.299000													6	51					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56300736	56300736	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:56300736A>T	ENST00000443188.1	-	10	3253	c.2543T>A	c.(2542-2544)aTc>aAc	p.I848N	NLRP11_ENST00000360133.3_Missense_Mutation_p.I794N|NLRP11_ENST00000589093.1_Missense_Mutation_p.I848N|NLRP11_ENST00000592953.1_Missense_Mutation_p.I749N|NLRP11_ENST00000589824.2_Missense_Mutation_p.I794N	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	848							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ATATTGACAGATATCGCTGCT	0.408000													17	147					0	0	1	0	0
AKAP17A	8227	broad.mit.edu	37	X	1713004	1713004	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:1713004G>C	ENST00000313871.3	+	2	845	c.649G>C	c.(649-651)Gcc>Ccc	p.A217P	AKAP17A_ENST00000381261.3_Missense_Mutation_p.A217P	NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	217	RRM.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						GAACTTCGAGGCCTATGTGCA	0.612000													21	163					0	0	1	0	0
ETS1	2113	broad.mit.edu	37	11	128359245	128359245	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:128359245C>G	ENST00000392668.3	-	5	543	c.475G>C	c.(475-477)Gag>Cag	p.E159Q	ETS1_ENST00000345075.4_Missense_Mutation_p.E115Q|ETS1_ENST00000531611.1_Missense_Mutation_p.E115Q|ETS1_ENST00000319397.5_Missense_Mutation_p.E115Q|ETS1_ENST00000535549.1_Intron|ETS1_ENST00000526145.1_Missense_Mutation_p.E115Q	NM_001143820.1	NP_001137292.1	P14921	ETS1_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog 1	115					cell motility|immune response|induction of apoptosis|negative regulation of cell cycle|negative regulation of cell proliferation|PML body organization|positive regulation of cellular component movement|positive regulation of erythrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|response to antibiotic|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|pleura(1)|prostate(1)|upper_aerodigestive_tract(3)	35	all_hematologic(175;0.0537)	Lung NSC(97;0.000542)|all_lung(97;0.000665)|Breast(109;0.00765)|all_neural(223;0.0351)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;1.47e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0174)|LUSC - Lung squamous cell carcinoma(976;0.0815)|Lung(307;0.0833)		GGGGCCAGCTCGAGAAAGCAG	0.493000													19	190					0	0	1	0	0
AGPAT3	56894	broad.mit.edu	37	21	45389112	45389112	+	Silent	SNP	C	C	T	rs143039422		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr21:45389112C>T	ENST00000398063.2	+	4	954	c.462C>T	c.(460-462)acC>acT	p.T154T	AGPAT3_ENST00000291572.8_Silent_p.T154T|AGPAT3_ENST00000546158.1_Silent_p.T154T|AGPAT3_ENST00000398061.1_Silent_p.T154T|AGPAT3_ENST00000327505.2_Silent_p.T154T|AGPAT3_ENST00000479117.1_3'UTR|AGPAT3_ENST00000398058.1_Silent_p.T154T	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	154					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		ACCGGGACACCGTGGTCGAAG	0.627000													17	77					0	0	1	0	0
CLPTM1	1209	broad.mit.edu	37	19	45477825	45477825	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:45477825G>T	ENST00000541297.2	+	4	862	c.397G>T	c.(397-399)Gag>Tag	p.E133*	CLPTM1_ENST00000337392.5_Nonsense_Mutation_p.E147*|CLPTM1_ENST00000546079.1_Nonsense_Mutation_p.E45*			O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane protein 1	147					cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CGGCTGCTACGAGCACTTTGC	0.577000													13	79					0.00244969	0.00267396	1	1	0
COL1A2	1278	broad.mit.edu	37	7	94057622	94057622	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:94057622C>A	ENST00000297268.6	+	50	4015	c.3544C>A	c.(3544-3546)Cct>Act	p.P1182T		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1182	Fibrillar collagen NC1.				axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTGGATTGACCCTAACCAAGG	0.383000										HNSCC(75;0.22)			23	184					5.45024e-15	8.36423e-15	1	1	0
DNAJC27	51277	broad.mit.edu	37	2	25180693	25180693	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:25180693C>A	ENST00000264711.2	-	4	580	c.391G>T	c.(391-393)Gtt>Ttt	p.V131F	DNAJC27_ENST00000468467.1_5'UTR|DNAJC27_ENST00000534855.1_Missense_Mutation_p.V60F	NM_001198559.1|NM_016544.2	NP_001185488.1|NP_057628.1	Q9NZQ0	DJC27_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 27	131					protein folding|small GTPase mediated signal transduction		GTP binding|heat shock protein binding|unfolded protein binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						TTGGCACAAACTACAAATATA	0.423000													17	107					3.52763e-06	4.32239e-06	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8500944	8500944	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:8500944G>A	ENST00000381196.4	-	21	2481	c.1938C>T	c.(1936-1938)tcC>tcT	p.S646S	PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000360074.4_Silent_p.S633S|PTPRD_ENST00000358503.5_Silent_p.S633S|PTPRD_ENST00000540109.1_Silent_p.S646S|PTPRD_ENST00000356435.5_Silent_p.S646S|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000471274.1_5'UTR	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	646	Fibronectin type-III 4.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGTACTTGATGGAGTATTCAG	0.438000										TSP Lung(15;0.13)			22	151					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37186536	37186536	+	RNA	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:37186536A>T	ENST00000425901.2	+	0	378					NR_033753.2																						AGATCCCCCTAAGGAGGTAGA	0.592000													91	37					0	0	1	0	0
SUN1	23353	broad.mit.edu	37	7	888078	888078	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:888078A>G	ENST00000456758.2	+	9	856	c.856A>G	c.(856-858)Agg>Ggg	p.R286G	SUN1_ENST00000405266.1_Intron|SUN1_ENST00000401592.1_Intron|SUN1_ENST00000389574.3_Intron|SUN1_ENST00000452783.2_Intron|SUN1_ENST00000425407.2_Intron			O94901	SUN1_HUMAN	Sad1 and UNC84 domain containing 1	0	EMD-binding.|SYNE2-binding.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTACGTGAATAGGATTTTGTG	0.363000													35	173					0	0	1	0	0
ACY1	95	broad.mit.edu	37	3	52021460	52021460	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:52021460G>T	ENST00000458031.2	+	13	1344	c.1113G>T	c.(1111-1113)gtG>gtT	p.V371V	ACY1_ENST00000476854.1_Intron|ACY1_ENST00000476351.1_Silent_p.V246V|ABHD14A-ACY1_ENST00000463937.1_Silent_p.V382V|ACY1_ENST00000494103.1_Silent_p.V209V|ACY1_ENST00000404366.2_Silent_p.V281V			Q03154	ACY1_HUMAN	aminoacylase 1	281					cellular amino acid metabolic process|proteolysis	cytosol	aminoacylase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	11				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	L-Aspartic Acid(DB00128)	CACCGGATGTGGACTTCAAGG	0.577000													4	45					0.000602214	0.000671534	1	1	0
CDC73	79577	broad.mit.edu	37	1	193121524	193121524	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:193121524A>G	ENST00000367435.3	+	10	1106	c.922A>G	c.(922-924)Aaa>Gaa	p.K308E		NM_024529.4	NP_078805.3	Q6P1J9	CDC73_HUMAN	cell division cycle 73	308					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(14)|ovary(1)|pancreas(1)|parathyroid(51)|skin(1)|upper_aerodigestive_tract(1)	87						GGAAGGCTTCAAAATTGACAC	0.323000													16	37					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78766949	78766949	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:78766949C>A	ENST00000436010.2	-	4	1622	c.625G>T	c.(625-627)Gaa>Taa	p.E209*	ROBO1_ENST00000495273.1_Nonsense_Mutation_p.E209*|ROBO1_ENST00000467549.1_Nonsense_Mutation_p.E209*|ROBO1_ENST00000464233.1_Nonsense_Mutation_p.E248*			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	248	Ig-like C2-type 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTCTCACGTTCCCCAACCATA	0.363000													5	34					0.014758	0.0153781	1	1	0
PDIA4	9601	broad.mit.edu	37	7	148703051	148703051	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:148703051T>C	ENST00000286091.4	-	8	1458	c.1226A>G	c.(1225-1227)tAc>tGc	p.Y409C		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	409					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			GCGCCTGGTGTAGCGCTTAGC	0.617000											OREG0018420	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	62					0	0	1	0	0
VPS11	55823	broad.mit.edu	37	11	118948671	118948671	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:118948671C>T	ENST00000300793.6	+	11	1695	c.1653C>T	c.(1651-1653)ctC>ctT	p.L551L	VPS11_ENST00000527798.1_3'UTR	NM_021729.4	NP_068375.3	Q9H270	VPS11_HUMAN	vacuolar protein sorting 11 homolog (S. cerevisiae)	552					protein transport	endocytic vesicle|HOPS complex|late endosome membrane|lysosomal membrane	nucleotide binding|protein binding|zinc ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	29	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.88e-05)		GCAAGATCCTCATGCACCACA	0.532000													16	206					0	0	1	0	0
RGS4	5999	broad.mit.edu	37	1	163039171	163039171	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:163039171A>G	ENST00000421743.2	+	2	348	c.188A>G	c.(187-189)gAc>gGc	p.D63G	RGS4_ENST00000531057.1_5'UTR|RGS4_ENST00000367908.4_5'UTR|RGS4_ENST00000491263.1_3'UTR|RGS4_ENST00000527809.1_5'UTR|RGS4_ENST00000367909.6_5'UTR	NM_001102445.2|NM_001113380.1	NP_001095915.1|NP_001106851.1	P49798	RGS4_HUMAN	regulator of G-protein signaling 4	0	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	plasma membrane	calmodulin binding|GTPase activator activity|signal transducer activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|upper_aerodigestive_tract(2)	21						GAGGATTCTGACAATATCTTT	0.517000											OREG0013952	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	15					0	0	1	0	0
PLEKHF1	79156	broad.mit.edu	37	19	30164955	30164955	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:30164955A>G	ENST00000436066.3	+	2	675	c.209A>G	c.(208-210)aAc>aGc	p.N70S	PLEKHF1_ENST00000592810.1_Missense_Mutation_p.N70S	NM_024310.4	NP_077286.3	Q96S99	PKHF1_HUMAN	pleckstrin homology domain containing, family F (with FYVE domain) member 1	70	PH.				apoptosis	lysosome|nucleus|perinuclear region of cytoplasm	metal ion binding			breast(1)|lung(3)|ovary(1)|prostate(1)	6	Ovarian(5;0.000567)|Breast(6;0.0602)|Esophageal squamous(110;0.239)		UCEC - Uterine corpus endometrioid carcinoma (4;2.65e-06)|STAD - Stomach adenocarcinoma(5;1.7e-06)|Lung(7;0.0623)|LUAD - Lung adenocarcinoma(5;0.0989)|BRCA - Breast invasive adenocarcinoma(6;0.225)			ATCGTGCTCAACAAGCGCAAG	0.592000													7	79					0	0	1	0	0
NEU2	4759	broad.mit.edu	37	2	233899005	233899005	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:233899005C>T	ENST00000233840.3	+	2	381	c.381C>T	c.(379-381)gtC>gtT	p.V127V		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	127							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		TGTGCCAAGTCACCAGCACTG	0.637000													11	68					0	0	1	0	0
HTR2B	3357	broad.mit.edu	37	2	231973824	231973824	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:231973824C>T	ENST00000258400.3	-	4	1365	c.853G>A	c.(853-855)Gat>Aat	p.D285N	PSMD1_ENST00000409643.1_Intron|PSMD1_ENST00000373635.4_Intron|PSMD1_ENST00000308696.6_Intron|PSMD1_ENST00000488354.1_3'UTR	NM_000867.4	NP_000858.3	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	285					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	11		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	CGAGAACCATCCAGCATTGCC	0.468000													35	151					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17451904	17451904	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:17451904G>T	ENST00000261381.6	-	2	451	c.367C>A	c.(367-369)Cca>Aca	p.P123T	XYLT1_ENST00000568226.1_5'UTR	NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	123					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CTTGGGTGTGGATCCTGTAGG	0.418000													3	30					0.004672	0.00498561	1	1	0
TTN	7273	broad.mit.edu	37	2	179642521	179642521	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:179642521C>G	ENST00000589042.1	-	25	4614	c.4390G>C	c.(4390-4392)Gtt>Ctt	p.V1464L	TTN_ENST00000460472.2_Missense_Mutation_p.V1418L|TTN_ENST00000342175.6_Missense_Mutation_p.V1418L|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.V1464L|TTN_ENST00000342992.6_Missense_Mutation_p.V1464L|TTN_ENST00000591111.1_Missense_Mutation_p.V1464L|TTN_ENST00000359218.5_Missense_Mutation_p.V1418L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1464	Ig-like 6.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTGAAAGAAACAGGTTTTAAC	0.443000													7	101					0	0	1	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130374009	130374009	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:130374009A>G	ENST00000529410.1	+	9	934	c.455A>G	c.(454-456)cAg>cGg	p.Q152R	L3MBTL3_ENST00000368139.2_Missense_Mutation_p.Q127R|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.Q127R|L3MBTL3_ENST00000526019.1_Missense_Mutation_p.Q127R|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.Q152R|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.Q152R			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	152					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		AACAGAGATCAGAAGGAAGAA	0.348000													12	42					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	6007177	6007177	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:6007177C>A	ENST00000378156.4	-	9	1371	c.1106G>T	c.(1105-1107)gGa>gTa	p.G369V	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	369					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GCCGTCCACTCCTGCAGGGCT	0.542000													8	58					1	1	1	1	0
CD109	135228	broad.mit.edu	37	6	74475671	74475671	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:74475671G>C	ENST00000437994.2	+	11	1557	c.1126G>C	c.(1126-1128)Gat>Cat	p.D376H	CD109_ENST00000422508.2_Missense_Mutation_p.D299H|CD109_ENST00000287097.5_Missense_Mutation_p.D376H	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	376						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						AACTCGTGCTGATGGCAACCA	0.368000													5	64					0	0	1	0	0
SF3A1	10291	broad.mit.edu	37	22	30738815	30738815	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr22:30738815G>A	ENST00000439242.1	-	5	641	c.510C>T	c.(508-510)aaC>aaT	p.N170N	SF3A1_ENST00000215793.7_Silent_p.N235N	NM_001005409.1	NP_001005409.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	235					nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						CTTCTCGGGGGTTTTCAGCCT	0.413000													8	61					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30925143	30925143	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:30925143G>T	ENST00000597505.1	-	30	4395	c.4396C>A	c.(4396-4398)Cgt>Agt	p.R1466S	DCDC1_ENST00000406071.2_Missense_Mutation_p.R201S|DCDC1_ENST00000339794.5_Missense_Mutation_p.R545S			P59894	DCDC1_HUMAN	doublecortin domain containing 1	227					intracellular signal transduction			p.R153G(1)|p.R545G(1)		central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ACCAAATCACGCAAGGTAAAG	0.428000													7	15					0.0293803	0.0303092	1	1	0
CARD8	22900	broad.mit.edu	37	19	48725103	48725103	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:48725103C>A	ENST00000391898.3	-	8	1087	c.1045G>T	c.(1045-1047)Gat>Tat	p.D349Y	CARD8_ENST00000520015.1_Missense_Mutation_p.D349Y|ZNF114_ENST00000597695.1_Intron|CARD8_ENST00000521613.1_Missense_Mutation_p.D299Y|CARD8_ENST00000520753.1_Missense_Mutation_p.D349Y|CARD8_ENST00000447740.2_Missense_Mutation_p.D299Y|CARD8_ENST00000357778.5_Missense_Mutation_p.D74Y|CARD8_ENST00000519940.1_Missense_Mutation_p.D349Y|CARD8_ENST00000359009.4_Missense_Mutation_p.D243Y|CARD8_ENST00000520153.1_Missense_Mutation_p.D299Y	NM_001184900.1	NP_001171829.1	Q9Y2G2	CARD8_HUMAN	caspase recruitment domain family, member 8	243	CARD.				negative regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion	cytoplasm|nucleus	caspase activator activity|NACHT domain binding|protein homodimerization activity			endometrium(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	15		all_lung(116;0.000112)|Lung NSC(112;0.000192)|all_epithelial(76;0.000349)|all_neural(266;0.0228)|Ovarian(192;0.113)|Prostate(7;0.184)		OV - Ovarian serous cystadenocarcinoma(262;0.000112)|all cancers(93;0.000293)|Epithelial(262;0.0129)|GBM - Glioblastoma multiforme(486;0.0336)		TCTTCCTCATCATCTATCGCC	0.413000													5	49					3.59834e-05	4.26571e-05	1	1	0
TLR9	54106	broad.mit.edu	37	3	52257072	52257072	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:52257072C>A	ENST00000494383.1	-	5	1719	c.1720G>T	c.(1720-1722)Gga>Tga	p.G574*	TLR9_ENST00000360658.2_Silent_p.V420V|TLR9_ENST00000597542.1_Silent_p.V444V			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CCGACAGGTCCACGTAGCGCA	0.642000													24	118					1.85244e-09	2.55794e-09	1	1	0
CDKL4	344387	broad.mit.edu	37	2	39411790	39411790	+	Splice_Site	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:39411790T>C	ENST00000378803.1	-	7	735		c.e7-2		CDKL4_ENST00000395035.3_Splice_Site	NM_001009565.1	NP_001009565.1	Q5MAI5	CDKL4_HUMAN	cyclin-dependent kinase-like 4							cytoplasm	ATP binding|cyclin-dependent protein kinase activity			breast(1)|large_intestine(2)|liver(1)|lung(7)|ovary(1)	12		all_hematologic(82;0.248)				AAGAGTTTCCTGAAAAACAAG	0.323000													5	30					0	0	1	0	0
FKBP9	11328	broad.mit.edu	37	7	33014337	33014337	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:33014337G>C	ENST00000242209.4	+	2	499	c.330G>C	c.(328-330)aaG>aaC	p.K110N	FKBP9_ENST00000538443.1_Intron|AVL9_ENST00000404479.1_Intron|FKBP9_ENST00000538336.1_Missense_Mutation_p.K163N	NM_007270.3	NP_009201.2	O95302	FKBP9_HUMAN	FK506 binding protein 9, 63 kDa	110	PPIase FKBP-type 1.				protein folding	endoplasmic reticulum|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(13)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(1)	39			GBM - Glioblastoma multiforme(11;0.0156)			GTTTCGTGAAGATTCCCCCAA	0.448000													15	96					0	0	1	0	0
STARD13	90627	broad.mit.edu	37	13	33716508	33716508	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:33716508C>A	ENST00000336934.5	-	4	442	c.326G>T	c.(325-327)cGa>cTa	p.R109L	STARD13_ENST00000399365.3_5'UTR|STARD13_ENST00000255486.4_Missense_Mutation_p.R101L|STARD13_ENST00000487412.1_5'UTR	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	109	SAM.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		CGTATTTAGTCGTCTAAAAGG	0.358000													5	69					8.12818e-05	9.4727e-05	1	1	0
ACBD5	91452	broad.mit.edu	37	10	27497291	27497291	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:27497291T>A	ENST00000396271.3	-	10	1414	c.1288A>T	c.(1288-1290)Aga>Tga	p.R430*	ACBD5_ENST00000375901.1_Nonsense_Mutation_p.R321*|ACBD5_ENST00000375905.4_Nonsense_Mutation_p.R395*|ACBD5_ENST00000375888.1_Nonsense_Mutation_p.R439*|ACBD5_ENST00000476758.1_5'UTR|ACBD5_ENST00000375897.3_Nonsense_Mutation_p.R253*	NM_145698.3	NP_663736.2	Q5T8D3	ACBD5_HUMAN	acyl-CoA binding domain containing 5	439					transport	integral to membrane|peroxisomal membrane	fatty-acyl-CoA binding			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CGGGACCCTCTGTCGGAGCCC	0.562000													22	118					0	0	1	0	0
KCTD3	51133	broad.mit.edu	37	1	215751377	215751377	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:215751377G>T	ENST00000259154.4	+	6	644	c.350G>T	c.(349-351)cGt>cTt	p.R117L		NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	117						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity	p.R117H(1)		breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		GAATTGGAGCGTTCCTCTTGT	0.343000													26	97					1.17739e-12	1.75056e-12	1	1	0
TMPRSS15	5651	broad.mit.edu	37	21	19666685	19666685	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr21:19666685C>T	ENST00000284885.3	-	21	2421	c.2388G>A	c.(2386-2388)tgG>tgA	p.W796*		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	796	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						CAACCCAGGGCCAGGCCCCTT	0.527000													10	138					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76920161	76920161	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:76920161G>T	ENST00000373344.5	-	11	4130	c.3916C>A	c.(3916-3918)Caa>Aaa	p.Q1306K	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.Q1268K	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1306					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TCTTCATTTTGTTTTCCAGTT	0.368000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						8	56					3.09899e-07	3.99453e-07	1	1	0
CFHR3	10878	broad.mit.edu	37	1	196762604	196762604	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:196762604G>A	ENST00000367425.4	+	6	1046	c.954G>A	c.(952-954)gtG>gtA	p.V318V	CFHR3_ENST00000391985.3_Silent_p.V257V	NM_021023.5	NP_066303.2			complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						TTCAAGCAGTGTGTCGGGAAG	0.378000													13	141					0	0	1	0	0
FOXC2	2303	broad.mit.edu	37	16	86601175	86601175	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:86601175C>G	ENST00000320354.4	+	1	319	c.234C>G	c.(232-234)atC>atG	p.I78M	RP11-463O9.5_ENST00000563280.1_RNA	NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	78					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						ACAGCTACATCGCGCTCATCA	0.632000									Late-onset Hereditary Lymphedema				18	124					0	0	1	0	0
TRAF3	7187	broad.mit.edu	37	14	103371735	103371735	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:103371735T>G	ENST00000560371.1	+	11	1538	c.1321T>G	c.(1321-1323)Tac>Gac	p.Y441D	TRAF3_ENST00000351691.5_Missense_Mutation_p.Y416D|TRAF3_ENST00000539721.1_Missense_Mutation_p.Y358D|TRAF3_ENST00000392745.2_Missense_Mutation_p.Y441D|TRAF3_ENST00000347662.4_Missense_Mutation_p.Y416D	NM_003300.3|NM_145725.2	NP_003291.2|NP_663777.1	Q13114	TRAF3_HUMAN	TNF receptor-associated factor 3	441	MATH.				apoptosis|induction of apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|regulation of defense response to virus|regulation of interferon-beta production|regulation of proteolysis|toll-like receptor signaling pathway|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|endosome|internal side of plasma membrane|mitochondrion	signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|liver(2)|lung(7)|ovary(1)|prostate(2)	30		all_cancers(154;7.87e-06)|all_epithelial(191;0.0024)		Epithelial(152;9.92e-24)|all cancers(159;2.23e-21)|OV - Ovarian serous cystadenocarcinoma(161;7.85e-12)|Colorectal(3;0.0971)		CCTGTCCCTTTACAGCCAGCC	0.572000													14	72					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57938643	57938643	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:57938643C>T	ENST00000564448.1	-	26	2671	c.2611G>A	c.(2611-2613)Gga>Aga	p.G871R	CNGB1_ENST00000251102.8_Missense_Mutation_p.G877R			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	877					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						GATACCTGTCCGATCATCACA	0.567000													12	165					0	0	1	0	0
ZNF284	342909	broad.mit.edu	37	19	44590660	44590660	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:44590660C>G	ENST00000421176.3	+	5	1245	c.1029C>G	c.(1027-1029)taC>taG	p.Y343*	ZNF223_ENST00000591793.1_3'UTR	NM_001037813.2	NP_001032902.1	Q2VY69	ZN284_HUMAN	zinc finger protein 284	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	15		Prostate(69;0.0435)				AGAAACTATACAAATGTGAAG	0.373000													8	110					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64404627	64404627	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:64404627T>A	ENST00000262043.3	+	6	2993	c.2653T>A	c.(2653-2655)Tgc>Agc	p.C885S	PHF3_ENST00000393387.1_Missense_Mutation_p.C885S			Q92576	PHF3_HUMAN	PHD finger protein 3	885					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			AACTGTTACTTGCACAGGAGA	0.333000													27	81					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17294470	17294470	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:17294470C>A	ENST00000261381.6	-	4	1039	c.955G>T	c.(955-957)Gag>Tag	p.E319*		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	319					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGCATGTACTCCACGGAGTCC	0.567000													34	163					9.65963e-10	1.35804e-09	1	1	0
CLCN1	1180	broad.mit.edu	37	7	143048935	143048935	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:143048935G>T	ENST00000343257.2	+	23	2931	c.2844G>T	c.(2842-2844)gaG>gaT	p.E948D		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	948					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GCAAGGTAGAGGGCGAGTTGG	0.657000													12	70					1.08611e-07	1.42667e-07	1	1	0
SAMD9L	219285	broad.mit.edu	37	7	92763046	92763046	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:92763046C>A	ENST00000318238.4	-	5	3455	c.2239G>T	c.(2239-2241)Ggt>Tgt	p.G747C	SAMD9L_ENST00000437805.1_Missense_Mutation_p.G747C|SAMD9L_ENST00000411955.1_Missense_Mutation_p.G747C	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	747								p.G747C(1)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AGTGTGGTACCTCCACAGCCT	0.378000													22	151					2.70639e-06	3.36265e-06	1	1	0
IER3	8870	broad.mit.edu	37	6	30711923	30711923	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:30711923G>A	ENST00000376377.2	-	1	402	c.373C>T	c.(373-375)Ctt>Ttt	p.L125F	IER3_ENST00000259874.5_Silent_p.L87L			P46695	IEX1_HUMAN	immediate early response 3	0					anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding			NS(1)	1						GCAGCAGAAAGAGAAGCCTTT	0.627000													9	99					0	0	1	0	0
HIF3A	64344	broad.mit.edu	37	19	46815502	46815502	+	Silent	SNP	G	G	T	rs147931736		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:46815502G>T	ENST00000339613.2	+	7	942	c.687G>T	c.(685-687)gcG>gcT	p.A229A	HIF3A_ENST00000300862.3_Silent_p.A283A|HIF3A_ENST00000525854.1_3'UTR|HIF3A_ENST00000472815.1_Silent_p.A216A|HIF3A_ENST00000420102.2_Silent_p.A234A|HIF3A_ENST00000600383.1_Silent_p.A216A|HIF3A_ENST00000244303.6_Silent_p.A216A|HIF3A_ENST00000377670.4_Silent_p.A285A			Q9Y2N7	HIF3A_HUMAN	hypoxia inducible factor 3, alpha subunit	285	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(14)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	33		Ovarian(192;0.00965)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00204)|all cancers(93;0.0107)|GBM - Glioblastoma multiforme(486;0.0489)|Epithelial(262;0.136)		ACTCCGATGCGGTCAGCAAGA	0.622000													28	128					1.2476e-16	1.93862e-16	1	1	0
ORAI3	93129	broad.mit.edu	37	16	30964924	30964924	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:30964924C>T	ENST00000318663.4	+	2	871	c.647C>T	c.(646-648)tCt>tTt	p.S216F	ORAI3_ENST00000562699.1_Intron|ORAI3_ENST00000566237.1_Missense_Mutation_p.S216F|AC135048.13_ENST00000566056.1_RNA	NM_152288.2	NP_689501.1	Q9BRQ5	ORAI3_HUMAN	ORAI calcium release-activated calcium modulator 3	216						integral to membrane	protein binding			endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6						TCCTCTGCGTCTGCAGCACCG	0.677000											OREG0023742	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	278					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55136143	55136143	+	Nonsense_Mutation	SNP	C	C	T	rs140143120		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:55136143C>T	ENST00000314706.3	+	1	784	c.784C>T	c.(784-786)Cga>Tga	p.R262*		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	262					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						GGAAGGGAAACGAAAAGCTTT	0.438000													29	119					0	0	1	0	0
NARF	26502	broad.mit.edu	37	17	80439066	80439066	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:80439066G>T	ENST00000390006.4	+	7	1045	c.571G>T	c.(571-573)Gct>Tct	p.A191S	NARF_ENST00000412079.2_Missense_Mutation_p.A122S|NARF_ENST00000309794.10_Missense_Mutation_p.A250S|NARF_ENST00000345415.7_Missense_Mutation_p.A202S|NARF_ENST00000457415.3_Missense_Mutation_p.A296S	NM_001038618.2	NP_001033707.1	Q9UHQ1	NARF_HUMAN	nuclear prelamin A recognition factor	250						lamin filament	lamin binding	p.A250T(1)		endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.0143)|BRCA - Breast invasive adenocarcinoma(99;0.0369)			CTCCCGGGGCGCTGACTGCGT	0.582000													21	89					1.00905e-13	1.52588e-13	1	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110477324	110477324	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:110477324G>A	ENST00000378402.5	+	49	8367	c.8263G>A	c.(8263-8265)Gga>Aga	p.G2755R		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2755					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TGTAGCTTTGGGAGTGACATC	0.468000										HNSCC(38;0.096)			17	83					0	0	1	0	0
CLDN25	644672	broad.mit.edu	37	11	113650646	113650646	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:113650646G>T	ENST00000453129.2	+	1	178	c.129G>T	c.(127-129)atG>atT	p.M43I		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	43						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						TGAACGAGATGGAGACCTGGA	0.567000													21	130					1.01871e-10	1.4757e-10	1	1	0
LRP1	4035	broad.mit.edu	37	12	57578912	57578912	+	Silent	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:57578912A>T	ENST00000243077.3	+	40	6853	c.6387A>T	c.(6385-6387)acA>acT	p.T2129T		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	2129					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACAATGCCACAGACTCCGTGC	0.612000													6	92					0	0	1	0	0
TRIM49C	642612	broad.mit.edu	37	11	89774252	89774252	+	Missense_Mutation	SNP	G	G	A	rs145791878	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:89774252G>A	ENST00000448984.1	+	8	1222	c.893G>A	c.(892-894)aGt>aAt	p.S298N	TRIM49C_ENST00000432771.1_Intron	NM_001195234.1	NP_001182163.1	P0CI26	T49L2_HUMAN	tripartite motif containing 49C	298	B30.2/SPRY.					intracellular	zinc ion binding	p.S298N(4)		endometrium(3)|kidney(1)|lung(4)	8						GAAGCCAACAGTGATATCTTT	0.323000													4	47					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800547	185800547	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:185800547G>A	ENST00000302277.6	+	4	1018	c.424G>A	c.(424-426)Gtt>Att	p.V142I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	142						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						ATCAACAACTGTTACTGTGAG	0.348000													8	78					0	0	1	0	0
ALDOB	229	broad.mit.edu	37	9	104187792	104187792	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:104187792G>T	ENST00000374855.4	-	7	866	c.742C>A	c.(742-744)Caa>Aaa	p.Q248K		NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	248					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				ATAGCTACTTGTTCTGGAGTA	0.512000													13	99					2.61681e-11	3.80851e-11	1	1	0
KEL	3792	broad.mit.edu	37	7	142639553	142639553	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:142639553G>T	ENST00000355265.2	-	18	2479	c.2005C>A	c.(2005-2007)Ccc>Acc	p.P669T		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	669					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					ATCTGCTGGGGGCTGAGGTCC	0.577000													5	12					0.000602214	0.000671534	1	1	0
MEOX2	4223	broad.mit.edu	37	7	15666404	15666404	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:15666404C>G	ENST00000262041.5	-	2	1066	c.657G>C	c.(655-657)gaG>gaC	p.E219D		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	219					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TCACTGCTATCTCGTATCGCC	0.413000													17	107					0	0	1	0	0
SLFN12	55106	broad.mit.edu	37	17	33749699	33749699	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:33749699G>A	ENST00000394562.1	-	4	872	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	SLFN12_ENST00000304905.5_Silent_p.L117L|SLFN12_ENST00000452764.3_Silent_p.L117L			Q8IYM2	SLN12_HUMAN	schlafen family member 12	117							ATP binding			breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GTAATCCGCAGACCAGAGGTG	0.398000													6	87					0	0	1	0	0
SMC4	10051	broad.mit.edu	37	3	160146596	160146596	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:160146596A>T	ENST00000357388.3	+	18	3112	c.2661A>T	c.(2659-2661)ttA>ttT	p.L887F	RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000462787.1_Missense_Mutation_p.L887F|SMC4_ENST00000360111.2_Missense_Mutation_p.L887F|SMC4_ENST00000344722.5_Missense_Mutation_p.L887F|SMC4_ENST00000469762.1_Missense_Mutation_p.L862F	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	887					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTAAACGCTTACACAATACCA	0.313000													6	74					0	0	1	0	0
LMLN	89782	broad.mit.edu	37	3	197687287	197687287	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:197687287G>T	ENST00000330198.4	+	1	217	c.195G>T	c.(193-195)cgG>cgT	p.R65R	LMLN_ENST00000482695.1_Intron|LMLN_ENST00000332636.5_Intron|LMLN_ENST00000420910.2_Silent_p.R65R	NM_033029.3	NP_149018.2	Q96KR4	LMLN_HUMAN	leishmanolysin-like (metallopeptidase M8 family)	65					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		CTCCCTGCCGGCACCACGTCC	0.647000													8	53					3.09899e-07	3.99453e-07	1	1	0
ZNF451	26036	broad.mit.edu	37	6	57006773	57006773	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:57006773C>G	ENST00000370706.4	+	9	1128	c.884C>G	c.(883-885)tCt>tGt	p.S295C	RP11-203B9.4_ENST00000416069.2_RNA|RP11-203B9.4_ENST00000586053.1_RNA|ZNF451_ENST00000491832.2_Missense_Mutation_p.S295C|RP11-203B9.4_ENST00000592500.1_RNA|RP11-203B9.4_ENST00000585792.1_RNA|ZNF451_ENST00000357489.3_Missense_Mutation_p.S295C|RP11-203B9.4_ENST00000591553.1_RNA|RP11-203B9.4_ENST00000587815.1_RNA|RP11-203B9.4_ENST00000586668.1_RNA|RP11-203B9.4_ENST00000586432.1_RNA|RP11-203B9.4_ENST00000588811.1_RNA|RP11-203B9.4_ENST00000592038.1_RNA	NM_001031623.2	NP_001026794.1	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451	295					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			CATCCAATATCTTTCCCATCT	0.403000													5	56					0	0	1	0	0
CACNA1F	778	broad.mit.edu	37	X	49088147	49088147	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:49088147C>T	ENST00000376265.2	-	2	329	c.268G>A	c.(268-270)Gag>Aag	p.E90K	CACNA1F_ENST00000376251.1_Missense_Mutation_p.E25K|CACNA1F_ENST00000323022.5_Missense_Mutation_p.E90K	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	90					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	TGCTTCCACTCCACGATGCTG	0.622000													13	35					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14861878	14861878	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:14861878G>T	ENST00000285046.5	+	1	1410	c.1300G>T	c.(1300-1302)Gtg>Ttg	p.V434L	FGD5_ENST00000543601.1_Missense_Mutation_p.V193L	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	434					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						TGTGATGGGAGTGGGCCTGCC	0.642000													4	24					0.00909568	0.00962342	1	1	0
KMT2E	55904	broad.mit.edu	37	7	104748284	104748284	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:104748284A>G	ENST00000334877.4	+	22	3914	c.3380A>G	c.(3379-3381)gAt>gGt	p.D1127G	KMT2E_ENST00000257745.4_Missense_Mutation_p.D1127G|KMT2E_ENST00000311117.3_Missense_Mutation_p.D1127G|KMT2E_ENST00000334914.7_Missense_Mutation_p.D182G					lysine (K)-specific methyltransferase 2E																		ACTTCCGAAGATGGGCTTGTA	0.433000													5	49					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5922650	5922650	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:5922650C>T	ENST00000399933.3	-	8	3345	c.3346G>A	c.(3346-3348)Gaa>Aaa	p.E1116K	KIAA2026_ENST00000381461.2_Missense_Mutation_p.E1086K	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1116										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		GCTTTTCCTTCTTTATGCTGA	0.368000													8	131					0	0	1	0	0
GPR158	57512	broad.mit.edu	37	10	25887762	25887762	+	Silent	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:25887762T>A	ENST00000376351.3	+	11	3566	c.3207T>A	c.(3205-3207)gcT>gcA	p.A1069A	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	1069						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						TAGATAAGGCTGAAGTATGCC	0.463000													19	131					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688868	26688868	+	Silent	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr22:26688868C>G	ENST00000529632.2	+	2	787	c.591C>G	c.(589-591)ccC>ccG	p.P197P	SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000404234.3_Silent_p.P197P|SEZ6L_ENST00000403121.1_5'UTR|SEZ6L_ENST00000360929.3_Silent_p.P197P|SEZ6L_ENST00000343706.4_Silent_p.P197P|SEZ6L_ENST00000248933.6_Silent_p.P197P	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	197						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CTACAACACCCGCACCCCTGC	0.672000													22	101					0	0	1	0	0
PSAPL1	768239	broad.mit.edu	37	4	7436099	7436099	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:7436099G>A	ENST00000319098.4	-	1	601	c.508C>T	c.(508-510)Ccc>Tcc	p.P170S	SORCS2_ENST00000511199.1_Intron|SORCS2_ENST00000329016.9_Intron|SORCS2_ENST00000507866.2_Intron	NM_001085382.1	NP_001078851.1	Q6NUJ1	SAPL1_HUMAN	prosaposin-like 1 (gene/pseudogene)	170					sphingolipid metabolic process	extracellular region|lysosome				lung(4)	4						AAGGTAAGGGGCCCATTGGCC	0.637000													6	14					0	0	1	0	0
RFC1	5981	broad.mit.edu	37	4	39304215	39304215	+	Splice_Site	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:39304215C>T	ENST00000381897.1	-	18	2477	c.2343_splice	c.e18-1	p.G782_splice	RFC1_ENST00000349703.2_Splice_Site_p.G781_splice	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	782					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						ATCATAGCACCCTGAAATTGA	0.318000													9	54					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439610	52439610	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:52439610C>T	ENST00000242819.4	+	2	392	c.96C>T	c.(94-96)tcC>tcT	p.S32S		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	32						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		TGGCGGCATCCTCTCCCAGTA	0.507000													10	93					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118375038	118375038	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:118375038C>T	ENST00000534358.1	+	27	8454	c.8431C>T	c.(8431-8433)Cgc>Tgc	p.R2811C	KMT2A_ENST00000389506.5_Missense_Mutation_p.R2808C|KMT2A_ENST00000354520.4_Missense_Mutation_p.R2770C	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGAGTCAAGCCGCAGAGTCCA	0.438000													10	195					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188034	57188034	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:57188034C>T	ENST00000331162.4	-	5	1358	c.1088G>A	c.(1087-1089)aGc>aAc	p.S363N		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CGAGGATAAGCTAAAGGCTTG	0.443000													5	43					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231307808	231307808	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:231307808G>A	ENST00000264052.5	+	3	619	c.264G>A	c.(262-264)atG>atA	p.M88I	SP100_ENST00000427101.2_Missense_Mutation_p.M63I|SP100_ENST00000409897.1_Missense_Mutation_p.M53I|SP100_ENST00000409341.1_Missense_Mutation_p.M88I|SP100_ENST00000409824.1_Missense_Mutation_p.M63I|SP100_ENST00000340126.4_Missense_Mutation_p.M88I|SP100_ENST00000341950.4_Missense_Mutation_p.M88I|SP100_ENST00000409112.1_Missense_Mutation_p.M88I	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	88	HSR.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		CAAATAAAATGTTTGAAGTAA	0.358000													18	85					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348634	197348634	+	RNA	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:197348634G>C	ENST00000418868.1	-	0	625					NR_003266.2																						CAGCAGCACCGATGGGCCTGC	0.542000													7	102					0	0	1	0	0
FOXF2	2295	broad.mit.edu	37	6	1390753	1390753	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:1390753C>T	ENST00000259806.1	+	1	685	c.571C>T	c.(571-573)Cgc>Tgc	p.R191C		NM_001452.1	NP_001443.1	Q12947	FOXF2_HUMAN	forkhead box F2	191					epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			large_intestine(2)|lung(5)|prostate(1)	8	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		CTCGTTCCGCCGCCGGCCGCG	0.701000													17	51					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186123036	186123036	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:186123036C>A	ENST00000271588.4	+	97	15402	c.15173C>A	c.(15172-15174)aCa>aAa	p.T5058K	HMCN1_ENST00000367492.2_Missense_Mutation_p.T5058K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	5058	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTGGTTGAAACACTTCATGCA	0.413000													8	64					0.000157383	0.000181035	1	1	0
SLC9A4	389015	broad.mit.edu	37	2	103136408	103136408	+	Silent	SNP	G	G	T	rs142475556	byFrequency	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:103136408G>T	ENST00000295269.4	+	9	2269	c.1812G>T	c.(1810-1812)cgG>cgT	p.R604R		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	604					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						ACCAAGTTCGGCAAAGGGTGT	0.468000													12	73					3.07112e-06	3.79301e-06	1	1	0
CDC45	8318	broad.mit.edu	37	22	19504397	19504397	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr22:19504397C>T	ENST00000407835.1	+	18	1873	c.1617C>T	c.(1615-1617)caC>caT	p.H539H	CDC45_ENST00000437685.2_Silent_p.H571H|CDC45_ENST00000263201.1_Silent_p.H539H|CDC45_ENST00000404724.3_Silent_p.H493H			O75419	CDC45_HUMAN	cell division cycle 45	539					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						GGATGCTGCACAACCATTTTG	0.572000													10	46					0	0	1	0	0
FAM49B	51571	broad.mit.edu	37	8	130863099	130863099	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:130863099C>G	ENST00000519824.2	-	9	968	c.695G>C	c.(694-696)aGa>aCa	p.R232T	FAM49B_ENST00000522941.1_Missense_Mutation_p.R86T|FAM49B_ENST00000517654.1_Missense_Mutation_p.R232T|FAM49B_ENST00000519110.1_Missense_Mutation_p.R232T|FAM49B_ENST00000519540.1_Missense_Mutation_p.R232T|FAM49B_ENST00000522746.1_Missense_Mutation_p.R232T|FAM49B_ENST00000401979.2_Missense_Mutation_p.R232T|FAM49B_ENST00000523509.1_Missense_Mutation_p.R232T|FAM49B_ENST00000522250.1_Missense_Mutation_p.R86T	NM_016623.4	NP_057707.3	Q9NUQ9	FA49B_HUMAN	family with sequence similarity 49, member B	232										kidney(1)|large_intestine(6)|lung(4)|prostate(1)	12	Ovarian(5;0.000567)|Esophageal squamous(12;0.00693)|Acute lymphoblastic leukemia(118;0.155)		LUAD - Lung adenocarcinoma(14;0.0989)			CAGCATGACTCTGCATACACT	0.323000													8	60					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51923123	51923123	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:51923123G>C	ENST00000371117.3	-	16	1785	c.1510C>G	c.(1510-1512)Cag>Gag	p.Q504E	PKHD1_ENST00000340994.4_Missense_Mutation_p.Q504E	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	504					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ACACAGACCTGTACTTCTGGA	0.547000													26	94					0	0	1	0	0
RNF122	79845	broad.mit.edu	37	8	33406305	33406305	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:33406305T>C	ENST00000256257.1	-	6	835	c.434A>G	c.(433-435)cAg>cGg	p.Q145R		NM_024787.2	NP_079063.2	Q9H9V4	RN122_HUMAN	ring finger protein 122	145						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding			endometrium(2)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		CCCAATGTTCTGCGTGGCCTC	0.532000													32	155					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86108726	86108726	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:86108726G>C	ENST00000278487.3	+	6	1127	c.48G>C	c.(46-48)gaG>gaC	p.E16D	CCDC81_ENST00000354755.1_Missense_Mutation_p.E143D|CCDC81_ENST00000528728.1_Missense_Mutation_p.E16D|CCDC81_ENST00000445632.2_Missense_Mutation_p.E233D			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	233										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				AATGTGGAGAGAATAGAGAAA	0.433000													4	73					0	0	1	0	0
NUP93	9688	broad.mit.edu	37	16	56782199	56782199	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:56782199G>A	ENST00000569842.1	+	2	136	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	NUP93_ENST00000308159.5_Missense_Mutation_p.E14K			Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	14					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.E14K(3)		breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TCAGCAAGCTGAACAGCTTGC	0.517000													10	74					0	0	1	0	0
LRPPRC	10128	broad.mit.edu	37	2	44132864	44132864	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:44132864T>G	ENST00000260665.7	-	31	3388	c.3331A>C	c.(3331-3333)Atc>Ctc	p.I1111L		NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	1111					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGCGTTATGATGAGGCGGCTG	0.453000													14	78					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881903	228881903	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:228881903G>T	ENST00000392056.3	-	7	3713	c.3667C>A	c.(3667-3669)Ctg>Atg	p.L1223M	SPHKAP_ENST00000344657.5_Missense_Mutation_p.L1223M	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1223						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGAGACAGCAGGCCGGCTGTC	0.567000													19	112					8.28177e-16	1.27729e-15	1	1	0
GRID2	2895	broad.mit.edu	37	4	94690559	94690559	+	Silent	SNP	G	G	T	rs151216204	byFrequency	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:94690559G>T	ENST00000282020.4	+	15	2817	c.2559G>T	c.(2557-2559)acG>acT	p.T853T	GRID2_ENST00000510992.1_Silent_p.T758T	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	853					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGCTGGAGACGTGGTGGAACA	0.493000													15	81					1.49906e-05	1.79424e-05	1	1	0
LRRC18	474354	broad.mit.edu	37	10	50118298	50118298	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:50118298C>G	ENST00000374160.3	-	2	846	c.770G>C	c.(769-771)cGc>cCc	p.R257P	RP11-523O18.7_ENST00000430438.1_RNA|WDFY4_ENST00000325239.5_Intron|WDFY4_ENST00000413659.2_Intron	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	257						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						AGATGTCAAGCGTATTCTGGG	0.502000													14	78					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57175297	57175297	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:57175297C>T	ENST00000537055.2	-	2	1501	c.1270G>A	c.(1270-1272)Ggc>Agc	p.G424S		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AAAGCTTTGCCGCACTCGCCG	0.667000													15	55					0	0	1	0	0
OR8D4	338662	broad.mit.edu	37	11	123777454	123777454	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:123777454G>T	ENST00000321355.2	+	1	346	c.316G>T	c.(316-318)Gtt>Ttt	p.V106F		NM_001005197.1	NP_001005197.1	Q8NGM9	OR8D4_HUMAN	olfactory receptor, family 8, subfamily D, member 4	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|lung(16)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.93e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0409)		TTTTTTCTGTGTTTGTGTTAT	0.458000													15	229					0.00316338	0.00342884	1	1	0
SGIP1	84251	broad.mit.edu	37	1	67147557	67147557	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:67147557G>A	ENST00000371037.4	+	15	897	c.820G>A	c.(820-822)Gac>Aac	p.D274N	SGIP1_ENST00000371035.3_Intron|SGIP1_ENST00000371036.3_Intron|SGIP1_ENST00000371039.1_Intron|SGIP1_ENST00000237247.6_Missense_Mutation_p.D278N	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	274	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CACAGGAAATGACCAGTCAGC	0.408000													5	112					0	0	1	0	0
BRD7	29117	broad.mit.edu	37	16	50368765	50368765	+	Silent	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:50368765A>T	ENST00000394688.3	-	7	903	c.744T>A	c.(742-744)gcT>gcA	p.A248A	BRD7_ENST00000394689.2_Silent_p.A248A			Q9NPI1	BRD7_HUMAN	bromodomain containing 7	248					cell cycle|negative regulation of cell proliferation|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of histone acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|nucleus	histone acetyl-lysine binding|p53 binding|transcription coactivator activity|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(2)	22		all_cancers(37;0.0127)				TCTGCAAGTCAGCCATGAAGT	0.423000													19	83					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47746353	47746353	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:47746353G>A	ENST00000360380.3	-	13	2140	c.1777C>T	c.(1777-1779)Cca>Tca	p.P593S	STIL_ENST00000396221.2_Missense_Mutation_p.P593S|STIL_ENST00000371877.3_Missense_Mutation_p.P593S|STIL_ENST00000243182.6_Missense_Mutation_p.P593S|STIL_ENST00000337817.5_Missense_Mutation_p.P593S			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	593	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GATGGCAGTGGGGGAGTAGGT	0.448000													10	171					0	0	1	0	0
IGLV1-50	28821	broad.mit.edu	37	22	22682066	22682066	+	RNA	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr22:22682066T>G	ENST00000390291.2	+	0	299																											CCTGACCAATTCTCTGGCTCC	0.542000													22	218					0	0	1	0	0
GREB1	9687	broad.mit.edu	37	2	11756756	11756756	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:11756756G>T	ENST00000381486.2	+	21	3622		c.e21-1		GREB1_ENST00000396123.1_Splice_Site|GREB1_ENST00000234142.5_Splice_Site	NM_014668.3	NP_055483.2	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1							integral to membrane				breast(3)|central_nervous_system(2)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)	30	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		TTTTGGAACAGGCTCTACCTC	0.532000													40	270					1.57019e-19	2.50262e-19	1	1	0
DSCAM	1826	broad.mit.edu	37	21	41710195	41710195	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr21:41710195T>C	ENST00000400454.1	-	8	2093	c.1616A>G	c.(1615-1617)aAg>aGg	p.K539R		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	539	Ig-like C2-type 6.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GTTAGAGTTCTTGTACCATTT	0.443000													18	86					0	0	1	0	0
DCBLD2	131566	broad.mit.edu	37	3	98568333	98568333	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:98568333C>A	ENST00000326840.6	-	3	905	c.543G>T	c.(541-543)ttG>ttT	p.L181F	DCBLD2_ENST00000469648.1_5'UTR|DCBLD2_ENST00000326857.9_Missense_Mutation_p.L181F	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	181	CUB.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						AGTATGAGGCCAAAAATCCGC	0.348000													5	90					1	1	1	1	0
ZFP36	7538	broad.mit.edu	37	19	39899295	39899295	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:39899295C>T	ENST00000597629.1	+	2	1029	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	ZFP36_ENST00000248673.3_Missense_Mutation_p.P313S			P26651	TTP_HUMAN	ZFP36 ring finger protein	313					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGTGGCAGCCCCCCGGCGACT	0.622000													10	43					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139165277	139165277	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:139165277C>A	ENST00000395297.1	-	13	1611	c.1441G>T	c.(1441-1443)Gag>Tag	p.E481*		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	481								p.E481*(2)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCACCTGGCTCTGGACACCTT	0.393000										HNSCC(54;0.14)			13	61					0.00136819	0.00150404	1	1	0
CELSR2	1952	broad.mit.edu	37	1	109806904	109806904	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:109806904G>T	ENST00000271332.3	+	10	5267	c.5206G>T	c.(5206-5208)Ggt>Tgt	p.G1736C		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1736	Laminin G-like 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CCGGCTGCATGGTCTGCACCT	0.657000											OREG0013632	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	88					3.41278e-10	4.88666e-10	1	1	0
NUP98	4928	broad.mit.edu	37	11	3746414	3746414	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:3746414T>C	ENST00000324932.7	-	15	2186	c.1766A>G	c.(1765-1767)aAt>aGt	p.N589S	NUP98_ENST00000397004.4_Missense_Mutation_p.N589S|NUP98_ENST00000397007.4_Missense_Mutation_p.N606S|NUP98_ENST00000359171.4_Missense_Mutation_p.N589S|NUP98_ENST00000355260.3_Missense_Mutation_p.N589S	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	606					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		ATTGCTATTATTAAGGTTCTT	0.338000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								14	71					0	0	1	0	0
FOXO1	2308	broad.mit.edu	37	13	41134875	41134875	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:41134875C>A	ENST00000379561.5	-	2	1137	c.753G>T	c.(751-753)agG>agT	p.R251S		NM_002015.3	NP_002006.2	Q12778	FOXO1_HUMAN	forkhead box O1	251					anti-apoptosis|blood vessel development|embryo development|endocrine pancreas development|insulin receptor signaling pathway|negative regulation of stress-activated MAPK cascade|nerve growth factor receptor signaling pathway|pattern specification process|phosphatidylinositol-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|response to DNA damage stimulus|tissue development	cytosol|transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein kinase binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding		PAX7/FOXO1(197)|PAX3/FOXO1(749)	central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	20		Lung NSC(96;1.18e-05)|Breast(139;0.00394)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(188;0.194)		all cancers(112;7.32e-09)|Epithelial(112;2.87e-06)|OV - Ovarian serous cystadenocarcinoma(117;6.98e-05)|GBM - Glioblastoma multiforme(144;0.00394)|BRCA - Breast invasive adenocarcinoma(63;0.0815)		CAGCTCTTCTCCTAGGAGATT	0.507000													16	102					1.45105e-14	2.21045e-14	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228487601	228487601	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:228487601T>A	ENST00000570156.2	+	51	13567	c.13493T>A	c.(13492-13494)aTa>aAa	p.I4498K	OBSCN_ENST00000602685.1_3'UTR|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000366707.4_Missense_Mutation_p.I1188K|OBSCN_ENST00000284548.11_Intron|RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000359599.6_3'UTR|OBSCN_ENST00000422127.1_Intron	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3541	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCCAGATTCATAGAGGATATG	0.517000													28	88					0	0	1	0	0
CLEC10A	10462	broad.mit.edu	37	17	6980286	6980286	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:6980286G>T	ENST00000576617.1	-	4	474	c.205C>A	c.(205-207)Ctg>Atg	p.L69M	CLEC10A_ENST00000254868.4_Missense_Mutation_p.L69M|CLEC10A_ENST00000416562.2_Missense_Mutation_p.L69M|CLEC10A_ENST00000571664.1_Missense_Mutation_p.L69M			Q8IUN9	CLC10_HUMAN	C-type lectin domain family 10, member A	69					endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						AGGGTCACCAGGTCCCTCTGA	0.532000													18	64					1.02788e-11	1.4995e-11	1	1	0
CARD9	64170	broad.mit.edu	37	9	139261262	139261262	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:139261262G>C	ENST00000371732.5	-	10	1512	c.1347C>G	c.(1345-1347)ctC>ctG	p.L449L	CARD9_ENST00000371734.3_Silent_p.L449L|CARD9_ENST00000460290.1_5'UTR	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	449					positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		CTTTGTCTGAGAGCTGGGTGT	0.612000													7	94					0	0	1	0	0
CUX2	23316	broad.mit.edu	37	12	111758468	111758468	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:111758468C>T	ENST00000261726.6	+	17	2809	c.2655C>T	c.(2653-2655)ccC>ccT	p.P885P		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	885						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						CGCTGACCCCCGAGCAGTACG	0.677000													5	16					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8376571	8376571	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:8376571G>A	ENST00000332175.8	+	24	4436	c.3399G>A	c.(3397-3399)cgG>cgA	p.R1133R	PTPRM_ENST00000444013.1_Silent_p.R920R|PTPRM_ENST00000400053.4_Silent_p.R1071R|PTPRM_ENST00000400060.4_Silent_p.R1147R|PTPRM_ENST00000580170.1_Silent_p.R1146R	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1133	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				TGCGGTCACGGAGGGTGAACA	0.577000													6	64					0	0	1	0	0
TBC1D2B	23102	broad.mit.edu	37	15	78290658	78290658	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:78290658G>T	ENST00000300584.3	-	13	2735	c.2736C>A	c.(2734-2736)ttC>ttA	p.F912L	TBC1D2B_ENST00000492078.1_5'UTR|TBC1D2B_ENST00000409931.3_Intron	NM_015079.5|NM_144572.1	NP_055894.6|NP_653173.1	Q9UPU7	TBD2B_HUMAN	TBC1 domain family, member 2B	912						intracellular	protein binding|Rab GTPase activator activity			breast(3)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(2)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	26						GGCGTAGGGGGAAAGGGTTCA	0.607000													3	13					0.00909568	0.00962342	1	1	0
HNRNPA3	220988	broad.mit.edu	37	2	178080266	178080266	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:178080266G>T	ENST00000411529.2	+	2	57		c.e2-1		HNRNPA3_ENST00000435711.1_Splice_Site|HNRNPA3_ENST00000392524.2_Splice_Site	NM_194247.2	NP_919223.1	P51991	ROA3_HUMAN	heterogeneous nuclear ribonucleoprotein A3							catalytic step 2 spliceosome|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|urinary_tract(1)	16						CTTTCTCTCAGGGCCATGATC	0.358000													22	96					3.8784e-16	6.01153e-16	1	1	0
CD200R1L	344807	broad.mit.edu	37	3	112545958	112545958	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:112545958C>T	ENST00000488794.1	-	6	1087	c.498G>A	c.(496-498)tgG>tgA	p.W166*	CD200R1L_ENST00000398214.1_Nonsense_Mutation_p.W187*|CD200R1L_ENST00000448932.1_Nonsense_Mutation_p.W166*			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	187	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						TGCCATTGCCCCAGTATTCTT	0.517000													13	35					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427515	119427515	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:119427515C>A	ENST00000369429.3	-	8	1658	c.1649G>T	c.(1648-1650)gGg>gTg	p.G550V	TBX15_ENST00000207157.3_Missense_Mutation_p.G444V			Q96SF7	TBX15_HUMAN	T-box 15	550						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TCCAAAGGCCCCGTTGGAAGG	0.517000													6	77					0.00198382	0.00217309	1	1	0
OR7A17	26333	broad.mit.edu	37	19	14991322	14991322	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:14991322G>T	ENST00000327462.2	-	1	942	c.846C>A	c.(844-846)acC>acA	p.T282T		NM_030901.1	NP_112163.1	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A, member 17	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12	Ovarian(108;0.203)					TCAGCATGGGGGTGGCCACAG	0.453000													18	69					2.94398e-08	3.96798e-08	1	1	0
NRXN1	9378	broad.mit.edu	37	2	50850546	50850546	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:50850546C>A	ENST00000404971.1	-	7	2478	c.1139G>T	c.(1138-1140)gGa>gTa	p.G380V	NRXN1_ENST00000406859.3_Missense_Mutation_p.G347V|NRXN1_ENST00000406316.2_Missense_Mutation_p.G347V|NRXN1_ENST00000405472.3_Missense_Mutation_p.G347V|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000402717.3_Missense_Mutation_p.G347V|NRXN1_ENST00000401669.2_Missense_Mutation_p.G347V	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	347	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.G381E(1)|p.G380E(1)|p.G347E(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GGCCCCTGATCCCAAATTAAT	0.458000													20	127					1.33834e-09	1.85631e-09	1	1	0
SYNCRIP	10492	broad.mit.edu	37	6	86349987	86349987	+	Silent	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:86349987C>G	ENST00000355238.6	-	4	533	c.327G>C	c.(325-327)ggG>ggC	p.G109G	SYNCRIP_ENST00000369622.3_Silent_p.G109G	NM_001159673.1|NM_001159674.1|NM_001159676.1|NM_001159677.1|NM_001253771.1	NP_001153145.1|NP_001153146.1|NP_001153148.1|NP_001153149.1|NP_001240700.1	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA interacting protein	109					CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	33		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		CTACTTTGGTCCCTTGTTTTT	0.328000													8	123					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126372632	126372632	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:126372632C>A	ENST00000394329.3	+	9	10474	c.10461C>A	c.(10459-10461)acC>acA	p.T3487T	FAT4_ENST00000335110.5_Silent_p.T1785T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3487	Cadherin 33.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						ATTCAGGGACCCCCTCAGCTA	0.453000													13	156					0.00185496	0.00203553	1	1	0
SLC45A2	51151	broad.mit.edu	37	5	33947387	33947387	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:33947387G>A	ENST00000382102.3	-	6	1306	c.1249C>T	c.(1249-1251)Ctc>Ttc	p.L417F	SLC45A2_ENST00000342059.3_Missense_Mutation_p.L358F|SLC45A2_ENST00000296589.4_Missense_Mutation_p.L417F	NM_001012509.2	NP_001012527.1	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	417					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						TTCGGGAAGAGCCCAATAAAT	0.478000													26	165					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162468	33162468	+	RNA	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:33162468G>A	ENST00000510327.1	-	0	346																											GAGGTTGGACGTGGGGGAATT	0.522000													6	66					0	0	1	0	0
SP3	6670	broad.mit.edu	37	2	174828613	174828613	+	Splice_Site	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:174828613T>G	ENST00000310015.6	-	3	687		c.e3-2		SP3_ENST00000418194.2_5'UTR|SP3_ENST00000455789.2_Intron	NM_001172712.1|NM_003111.4	NP_001166183.1|NP_003102.1	Q02447	SP3_HUMAN	Sp3 transcription factor						negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	NS(2)|large_intestine(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.185)			CTGAGTGTCCTACCCCCAATG	0.706000													6	23					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101825111	101825111	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:101825111C>A	ENST00000370418.3	-	4	844	c.593G>T	c.(592-594)cGg>cTg	p.R198L		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	198	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding	p.R198Q(1)		breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		GATCACCGCCCGGGTCTCGGG	0.577000													9	37					1.76689e-08	2.38665e-08	1	1	0
GDF9	2661	broad.mit.edu	37	5	132199939	132199939	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:132199939T>C	ENST00000378673.2	-	2	1153	c.287A>G	c.(286-288)tAt>tGt	p.Y96C	GDF9_ENST00000296875.2_Missense_Mutation_p.Y96C|GDF9_ENST00000464378.1_5'UTR			O60383	GDF9_HUMAN	growth differentiation factor 9	96					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTGGTAGCATATGTCTTATA	0.517000													25	86					0	0	1	0	0
FANCA	2175	broad.mit.edu	37	16	89828400	89828400	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:89828400G>A	ENST00000389301.3	-	29	2839	c.2809C>T	c.(2809-2811)Ctg>Ttg	p.L937L	FANCA_ENST00000568369.1_Silent_p.L937L	NM_000135.2	NP_000126.2	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A	937					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TGAATTTCCAGCTCCAGGTGT	0.443000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				10	124					0	0	1	0	0
HERC1	8925	broad.mit.edu	37	15	63967119	63967119	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:63967119T>A	ENST00000443617.2	-	38	7355	c.7268A>T	c.(7267-7269)gAg>gTg	p.E2423V		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2423					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						CCCTTTCTCCTCGGATTCATG	0.473000													13	130					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139606339	139606339	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:139606339G>T	ENST00000303045.6	-	63	4982	c.4536C>A	c.(4534-4536)ggC>ggA	p.G1512G	COL22A1_ENST00000435777.1_Silent_p.G1492G|COL22A1_ENST00000341807.4_5'UTR	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1512	Collagen-like 15.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGCCGGCCCGGCCTGGAAGCC	0.667000										HNSCC(7;0.00092)			8	54					0.27861	0.280876	1	1	0
DUSP10	11221	broad.mit.edu	37	1	221879722	221879722	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:221879722C>A	ENST00000366899.3	-	3	1136	c.898G>T	c.(898-900)Gca>Tca	p.A300S	DUSP10_ENST00000544095.1_5'UTR|DUSP10_ENST00000323825.3_5'UTR|DUSP10_ENST00000468085.1_5'UTR	NM_007207.4	NP_009138.1	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10	300					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			NS(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(131;0.0103)		GCCGCGGATGCGCCGCCCCCC	0.577000													6	130					0.00116845	0.00128674	1	1	0
SLC35G2	80723	broad.mit.edu	37	3	136573597	136573597	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:136573597T>A	ENST00000446465.2	+	2	923	c.295T>A	c.(295-297)Ttt>Att	p.F99I	RP11-85F14.5_ENST00000470236.1_RNA|SLC35G2_ENST00000393079.3_Missense_Mutation_p.F99I|RP11-85F14.5_ENST00000474250.1_RNA|RP11-85F14.5_ENST00000461864.1_RNA	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	99						Golgi apparatus|integral to membrane											AAAAAACATTTTTCAATCCCG	0.423000													29	136					0	0	1	0	0
ANO7	50636	broad.mit.edu	37	2	242163566	242163566	+	Nonstop_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:242163566T>C	ENST00000274979.8	+	25	2903	c.2800T>C	c.(2800-2802)Tga>Cga	p.*934R		NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	0						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						GCTGCAGCAGTGACGCCTGGA	0.637000													5	40					0	0	1	0	0
ELAVL2	1993	broad.mit.edu	37	9	23701584	23701584	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:23701584C>A	ENST00000397312.2	-	5	780	c.506G>T	c.(505-507)gGg>gTg	p.G169V	ELAVL2_ENST00000380110.4_Missense_Mutation_p.G198V|ELAVL2_ENST00000380117.1_Missense_Mutation_p.G169V|ELAVL2_ENST00000223951.6_Missense_Mutation_p.G169V|ELAVL2_ENST00000544538.1_Missense_Mutation_p.G169V	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	169	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		TCGAATAAACCCTACACCCCT	0.428000													17	110					0.000566183	0.000637085	1	1	0
GADD45GIP1	90480	broad.mit.edu	37	19	13065227	13065227	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:13065227C>A	ENST00000316939.1	-	2	487	c.464G>T	c.(463-465)cGa>cTa	p.R155L		NM_052850.2	NP_443082.2	Q8TAE8	G45IP_HUMAN	growth arrest and DNA-damage-inducible, gamma interacting protein 1	155					cell cycle|interspecies interaction between organisms	nucleus	protein binding			ovary(2)|prostate(1)|skin(1)	4						AGCCTGCAGTCGGGCCCTCCT	0.627000													19	72					6.94344e-10	9.78394e-10	1	1	0
LRBA	987	broad.mit.edu	37	4	151770091	151770091	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:151770091A>T	ENST00000535741.1	-	26	4691	c.4218T>A	c.(4216-4218)ttT>ttA	p.F1406L	LRBA_ENST00000507224.1_Missense_Mutation_p.F1406L|LRBA_ENST00000357115.3_Missense_Mutation_p.F1406L|LRBA_ENST00000510413.1_Missense_Mutation_p.F1406L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1406						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GCCTCTGCAAAAATGTCACAG	0.338000													11	120					0	0	1	0	0
ST6GALNAC3	256435	broad.mit.edu	37	1	77093236	77093236	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:77093236C>A	ENST00000328299.3	+	4	871	c.723C>A	c.(721-723)acC>acA	p.T241T		NM_152996.2	NP_694541.2	Q8NDV1	SIA7C_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	241					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|ovary(3)|prostate(1)|skin(2)	36						TAAATGACACCTACTGCAAGT	0.408000													25	97					1.85244e-09	2.55794e-09	1	1	0
HMCN1	83872	broad.mit.edu	37	1	185972977	185972977	+	Splice_Site	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:185972977G>T	ENST00000271588.4	+	29	4704		c.e29+1		HMCN1_ENST00000367492.2_Splice_Site	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1						response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AAGATGGCAAGTGAGTATCTT	0.388000													15	72					1.52009e-12	2.25468e-12	1	1	0
OR10G4	390264	broad.mit.edu	37	11	123886663	123886663	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:123886663C>G	ENST00000320891.4	+	1	382	c.382C>G	c.(382-384)Ccg>Gcg	p.P128A		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CATCAGTTACCCGCTCAGGTA	0.557000													24	167					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80767500	80767500	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:80767500G>A	ENST00000533983.1	+	6	864	c.525G>A	c.(523-525)caG>caA	p.Q175Q	ARNT2_ENST00000531595.3_3'UTR|ARNT2_ENST00000303329.4_Silent_p.Q186Q|ARNT2_ENST00000527771.1_Silent_p.Q175Q			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	186	PAS 1.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			TGTATGAACAGGTGCATCCTG	0.522000													7	129					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40657159	40657159	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:40657159T>A	ENST00000406785.1	-	2	451	c.262A>T	c.(262-264)Atg>Ttg	p.M88L	SLC8A1_ENST00000408028.2_Missense_Mutation_p.M88L|SLC8A1_ENST00000542024.1_Missense_Mutation_p.M88L|SLC8A1_ENST00000406391.2_Missense_Mutation_p.M88L|SLC8A1_ENST00000405901.3_Missense_Mutation_p.M88L|SLC8A1_ENST00000405269.1_Missense_Mutation_p.M88L|SLC8A1_ENST00000403092.1_Missense_Mutation_p.M88L|SLC8A1_ENST00000332839.4_Missense_Mutation_p.M88L|SLC8A1_ENST00000542756.1_Missense_Mutation_p.M88L|SLC8A1_ENST00000402441.1_Missense_Mutation_p.M88L			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	88					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding	p.M88L(1)		NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CCAAGAAACATGTAGACCATG	0.413000													18	128					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64394906	64394906	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:64394906C>G	ENST00000262043.3	+	4	1623	c.1283C>G	c.(1282-1284)aCt>aGt	p.T428S	PHF3_ENST00000509330.1_Missense_Mutation_p.T428S|PHF3_ENST00000393387.1_Missense_Mutation_p.T428S			Q92576	PHF3_HUMAN	PHD finger protein 3	428					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GATACTAGTACTTTTGGACCG	0.363000													27	144					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55968070	55968070	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:55968070T>C	ENST00000263923.4	-	15	2555	c.2260A>G	c.(2260-2262)Ata>Gta	p.I754V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	754					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TGACCTTCTATTATGAAAAAT	0.463000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			4	68					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552626	1552626	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:1552626G>T	ENST00000381605.4	-	3	555	c.491C>A	c.(490-492)aCa>aAa	p.T164K	SIRPB1_ENST00000262929.5_Intron|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	164	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GAAGCTCACTGTGTGCTCAGG	0.542000													24	119					2.70639e-06	3.36265e-06	1	1	0
MAGEC1	9947	broad.mit.edu	37	X	140996384	140996384	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:140996384C>A	ENST00000285879.4	+	4	3480	c.3194C>A	c.(3193-3195)cCt>cAt	p.P1065H	MAGEC1_ENST00000406005.2_Missense_Mutation_p.P132H	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	1065	MAGE.						protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTCTCCTCCTCGTTACGAA	0.498000										HNSCC(15;0.026)			35	73					8.73648e-17	1.36096e-16	1	1	0
TMEM132D	121256	broad.mit.edu	37	12	129558589	129558589	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:129558589C>A	ENST00000422113.2	-	9	3457	c.3131G>T	c.(3130-3132)aGg>aTg	p.R1044M	TMEM132D_ENST00000389441.4_Missense_Mutation_p.R582M	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	1044						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		AAATTTTACCCTTTTCCTTTT	0.498000													12	105					6.40141e-05	7.51681e-05	1	1	0
CLN8	2055	broad.mit.edu	37	8	1719242	1719242	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:1719242G>C	ENST00000331222.4	+	2	269	c.22G>C	c.(22-24)Ggc>Cgc	p.G8R		NM_018941.3	NP_061764.2	Q9UBY8	CLN8_HUMAN	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	8					cell death|ceramide biosynthetic process|cholesterol metabolic process|lipid transport|negative regulation of proteolysis|phospholipid metabolic process	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.67e-05)|READ - Rectum adenocarcinoma(644;0.0913)		GAGCGATGGGGGCACATCAGA	0.542000													7	99					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021507	46021507	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr21:46021507C>G	ENST00000380102.2	+	1	1011	c.986C>G	c.(985-987)cCc>cGc	p.P329R	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	329	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						TGCTGCGTGCCCGTCCCCTCC	0.711000													6	87					0	0	1	0	0
TRPA1	8989	broad.mit.edu	37	8	72958838	72958838	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:72958838C>A	ENST00000262209.4	-	17	2178	c.1971G>T	c.(1969-1971)gaG>gaT	p.E657D	RP11-383H13.1_ENST00000537896.1_Intron|RP11-383H13.1_ENST00000524152.1_Intron|RP11-383H13.1_ENST00000457356.4_Intron	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	657						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TGAAATTATACTCGATCTGTA	0.299000													10	53					1.76689e-08	2.38665e-08	1	1	0
INSR	3643	broad.mit.edu	37	19	7122757	7122757	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:7122757G>A	ENST00000341500.5	-	18	3400	c.3361C>T	c.(3361-3363)Ctt>Ttt	p.L1121F	INSR_ENST00000302850.5_Missense_Mutation_p.L1133F	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1133	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ATCTCTTGAAGGGTAGGGGGA	0.572000													9	58					0	0	1	0	0
LAPTM5	7805	broad.mit.edu	37	1	31230536	31230536	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:31230536G>A	ENST00000294507.3	-	1	131	c.57C>T	c.(55-57)atC>atT	p.I19I	LAPTM5_ENST00000476492.1_5'UTR	NM_006762.2	NP_006753.1	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	19					transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		CGGTGGTTGCGATGCGGACAT	0.632000													5	26					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969720	240969720	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:240969720G>T	ENST00000402971.2	-	1	186	c.127C>A	c.(127-129)Ctg>Atg	p.L43M		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		ATGATGGCCAGGTTCTCCACC	0.582000													14	194					2.32078e-09	3.19753e-09	1	1	0
GPR37	2861	broad.mit.edu	37	7	124404651	124404651	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:124404651C>A	ENST00000303921.2	-	1	1030	c.380G>T	c.(379-381)gGt>gTt	p.G127V		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	127						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						AGGCTCCTGACCCCGAGCACC	0.677000													24	125					4.87955e-14	7.41501e-14	1	1	0
XIST	7503	broad.mit.edu	37	X	73066879	73066879	+	RNA	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:73066879G>A	ENST00000429829.1	-	0	5709					NR_001564.2																						AACTGAAAATGTGTATATAAC	0.403000													10	31					0	0	1	0	0
MRC2	9902	broad.mit.edu	37	17	60758261	60758261	+	Silent	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:60758261C>G	ENST00000303375.5	+	17	2976	c.2574C>G	c.(2572-2574)gcC>gcG	p.A858A		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	858	C-type lectin 5.				endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGTTCCAGGCCGAGCTGACCT	0.642000													3	28					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21251000	21251000	+	Splice_Site	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:21251000G>C	ENST00000298925.5	+	15	1786	c.1633_splice	c.e15+1	p.A545_splice	NELL1_ENST00000532434.1_Splice_Site_p.A517_splice|NELL1_ENST00000357134.5_Splice_Site_p.A517_splice|NELL1_ENST00000325319.5_Splice_Site_p.A460_splice			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	517	EGF-like 4.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						CATCTGCAGAGGTAGGCTTGC	0.567000													6	43					0	0	1	0	0
PRDM14	63978	broad.mit.edu	37	8	70981407	70981407	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:70981407G>T	ENST00000276594.2	-	2	890	c.689C>A	c.(688-690)cCa>cAa	p.P230Q		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			AGAGCTGTCTGGGGGGACCAG	0.612000													13	88					1.5842e-08	2.15396e-08	1	1	0
TCEA1	6917	broad.mit.edu	37	8	54891616	54891616	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:54891616T>A	ENST00000521604.2	-	8	1197	c.794A>T	c.(793-795)aAa>aTa	p.K265I	TCEA1_ENST00000396401.3_Missense_Mutation_p.K244I|TCEA1_ENST00000522635.1_Missense_Mutation_p.K81I|TCEA1_ENST00000521086.2_5'UTR	NM_006756.2	NP_006747.1	P23193	TCEA1_HUMAN	transcription elongation factor A (SII), 1	265					positive regulation of viral transcription|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|translation elongation factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		Lung NSC(129;0.109)|all_epithelial(80;0.11)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;9.1e-07)|Epithelial(17;9.44e-05)|all cancers(17;0.000699)			CTTTTTACATTTGCCACATGT	0.373000			T	PLAG1	salivary adenoma								4	61					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50677845	50677845	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:50677845C>G	ENST00000446044.1	+	5	864	c.268C>G	c.(268-270)Cag>Gag	p.Q90E	MAPKAPK3_ENST00000357955.2_Missense_Mutation_p.Q90E	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	90	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		CCATCACTGGCAGGCTTCTGG	0.552000													13	216					0	0	1	0	0
G6PC2	57818	broad.mit.edu	37	2	169763195	169763195	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:169763195G>C	ENST00000375363.3	+	4	554	c.462G>C	c.(460-462)tgG>tgC	p.W154C	G6PC2_ENST00000429379.2_Intron|G6PC2_ENST00000421979.1_Intron|G6PC2_ENST00000461586.1_Intron|SPC25_ENST00000472216.2_Intron	NM_021176.2	NP_066999.1	Q9NQR9	G6PC2_HUMAN	glucose-6-phosphatase, catalytic, 2	154					gluconeogenesis|glucose homeostasis|glucose transport|regulation of insulin secretion|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphatase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(5)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	13						CATTTCTTTGGAGTGTTTTTT	0.373000													17	142					0	0	1	0	0
SCAND3	114821	broad.mit.edu	37	6	28541447	28541447	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:28541447G>T	ENST00000452236.2	-	4	2836	c.2219C>A	c.(2218-2220)tCa>tAa	p.S740*		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	740					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ctcaatatatgaaggatcata	0.338000													12	42					4.36969e-10	6.19956e-10	1	1	0
EPG5	57724	broad.mit.edu	37	18	43462398	43462398	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:43462398T>A	ENST00000282041.5	-	31	5393	c.5359A>T	c.(5359-5361)Agg>Tgg	p.R1787W	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	1787					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TCCAGAAGCCTGGTACGATCA	0.403000													10	94					0	0	1	0	0
ATP9B	374868	broad.mit.edu	37	18	77067081	77067081	+	Silent	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:77067081A>T	ENST00000426216.2	+	15	1637	c.1620A>T	c.(1618-1620)cgA>cgT	p.R540R	ATP9B_ENST00000307671.7_Silent_p.R540R	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	540					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TCAGTAGTCGAATCCATGAAG	0.502000													11	73					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34917756	34917756	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:34917756G>A	ENST00000359791.1	+	9	1222	c.1094G>A	c.(1093-1095)gGt>gAt	p.G365D	NPSR1_ENST00000531252.1_Missense_Mutation_p.G354D	NM_207173.1	NP_997056.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	0						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	AACTGGAAGGGTACTTGGCCA	0.557000													3	13					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61305019	61305019	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:61305019G>T	ENST00000341074.5	-	8	1222	c.1107C>A	c.(1105-1107)ttC>ttA	p.F369L	SERPINB4_ENST00000356424.6_Missense_Mutation_p.F317L	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TGAAGAATAGGAAAGGGTGAT	0.423000													37	171					1.96642e-18	3.08653e-18	1	1	0
LAMA5	3911	broad.mit.edu	37	20	60900472	60900472	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:60900472C>A	ENST00000252999.3	-	41	5495	c.5429G>T	c.(5428-5430)aGg>aTg	p.R1810M		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1810	Laminin IV type A.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGTGCCACCCTGCGCAGGAA	0.672000													8	31					0.000157383	0.000181035	1	1	0
FSD1	79187	broad.mit.edu	37	19	4318918	4318918	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:4318918C>A	ENST00000221856.6	+	10	1156	c.1009C>A	c.(1009-1011)Cgc>Agc	p.R337S	FSD1_ENST00000597590.1_Missense_Mutation_p.R337S|FSD1_ENST00000598010.1_3'UTR	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	337	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGACGGGACCGCTTCACCGC	0.602000													9	39					0.000442599	0.00049893	1	1	0
ACPL2	92370	broad.mit.edu	37	3	141011680	141011680	+	Missense_Mutation	SNP	G	G	T	rs138707752		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:141011680G>T	ENST00000508812.1	+	5	2956	c.1049G>T	c.(1048-1050)cGg>cTg	p.R350L	ACPL2_ENST00000286353.4_Missense_Mutation_p.R359L|ACPL2_ENST00000504264.1_Missense_Mutation_p.R342L|RP11-438D8.2_ENST00000507698.1_RNA|ACPL2_ENST00000502783.1_Missense_Mutation_p.R321L|ACPL2_ENST00000393007.1_Missense_Mutation_p.R343L|ACPL2_ENST00000393010.2_Missense_Mutation_p.R359L			Q8TE99	ACPL2_HUMAN	acid phosphatase-like 2	359						extracellular region	acid phosphatase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(2)	23						ACCATCGGCCGGATGCAGCGT	0.542000													22	94					1.28384e-07	1.67928e-07	1	1	0
CPXCR1	53336	broad.mit.edu	37	X	88009007	88009007	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:88009007A>G	ENST00000276127.4	+	3	851	c.592A>G	c.(592-594)Agg>Ggg	p.R198G	CPXCR1_ENST00000373111.1_Missense_Mutation_p.R198G	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	198						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						AACATTTAGAAGGCCTTCGAG	0.433000													4	23					0	0	1	0	0
FOXG1	2290	broad.mit.edu	37	14	29237947	29237947	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:29237947A>G	ENST00000382535.3	+	2	1831	c.1462A>G	c.(1462-1464)Ata>Gta	p.I488V	FOXG1_ENST00000313071.4_Missense_Mutation_p.I488V			P55316	FOXG1_HUMAN	forkhead box G1	488					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CAACCCTTTAATACATTAACA	0.373000													12	42					0	0	1	0	0
FAM81B	153643	broad.mit.edu	37	5	94784045	94784045	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:94784045C>G	ENST00000283357.5	+	9	1148	c.1102C>G	c.(1102-1104)Cag>Gag	p.Q368E		NM_152548.2	NP_689761.2	Q96LP2	FA81B_HUMAN	family with sequence similarity 81, member B	368										central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(142;1.1e-06)|all_epithelial(76;1.48e-09)|all_lung(232;0.000696)|Lung NSC(167;0.000947)|Ovarian(225;0.00473)		all cancers(79;1.04e-16)		CATTAACACACAGAAACAGGA	0.328000													12	41					0	0	1	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232577115	232577115	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:232577115G>C	ENST00000366630.1	-	13	3922	c.3564C>G	c.(3562-3564)tcC>tcG	p.S1188S	SIPA1L2_ENST00000262861.4_Silent_p.S1188S|SIPA1L2_ENST00000308942.4_Silent_p.S262S			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1188					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity	p.S1188S(1)		NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCAGGACTTTGGAAGGTGGGC	0.413000													48	295					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	16918969	16918969	+	Silent	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:16918969C>G	ENST00000377833.4	-	57	9098	c.9033G>C	c.(9031-9033)ggG>ggC	p.G3011G		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	3011	CUB 22.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCAGAACCGGCCCAGCGATGG	0.488000													13	89					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	86068165	86068165	+	Silent	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:86068165C>G	ENST00000373131.1	+	8	1546	c.1383C>G	c.(1381-1383)cgC>cgG	p.R461R	DACH2_ENST00000510272.1_Silent_p.R255R|DACH2_ENST00000508860.1_Silent_p.R307R|DACH2_ENST00000373125.4_Silent_p.R474R|DACH2_ENST00000477378.2_3'UTR	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	474	DACHbox-C.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						ATAATGCTCGCATCCAGGAGA	0.378000													6	6					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216348676	216348676	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:216348676C>T	ENST00000366943.2	-	21	4931	c.4545G>A	c.(4543-4545)acG>acA	p.T1515T	USH2A_ENST00000366942.3_Silent_p.T1515T|USH2A_ENST00000307340.3_Silent_p.T1515T			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1515			T -> M (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTTCATCATCGTGGTCATCA	0.438000										HNSCC(13;0.011)			17	39					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33667445	33667445	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:33667445G>A	ENST00000321505.4	+	16	4912	c.4732G>A	c.(4732-4734)Gcc>Acc	p.A1578T	KIAA1549L_ENST00000389726.3_Missense_Mutation_p.A1584T					KIAA1549-like																		GCACCAAGAGGCCTACGGCTC	0.692000													6	27					0	0	1	0	0
KIAA1324	57535	broad.mit.edu	37	1	109734402	109734402	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:109734402A>G	ENST00000369939.3	+	13	1783	c.1600A>G	c.(1600-1602)Aaa>Gaa	p.K534E	KIAA1324_ENST00000369938.1_3'UTR|KIAA1324_ENST00000529753.1_Missense_Mutation_p.K447E	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	534					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TTCCAAAGGCAAACAGTCCTA	0.532000													13	179					0	0	1	0	0
GPR157	80045	broad.mit.edu	37	1	9164643	9164643	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:9164643G>A	ENST00000377411.4	-	4	985	c.843C>T	c.(841-843)ctC>ctT	p.L281L	GPR157_ENST00000414642.2_Silent_p.L216L	NM_024980.4	NP_079256.4	Q5UAW9	GP157_HUMAN	G protein-coupled receptor 157	281						integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(4)|prostate(1)	5	all_lung(157;0.185)	all_epithelial(116;5.02e-20)|all_lung(118;3.6e-06)|Lung NSC(185;7.93e-06)|Renal(390;0.000147)|Breast(348;0.000688)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.16e-07)|COAD - Colon adenocarcinoma(227;7.73e-05)|Kidney(185;0.000252)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.00178)|BRCA - Breast invasive adenocarcinoma(304;0.00186)|READ - Rectum adenocarcinoma(331;0.0642)		CGCGGGTGCAGAGGACGAACA	0.607000													4	30					0	0	1	0	0
CRABP2	1382	broad.mit.edu	37	1	156670413	156670413	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:156670413C>G	ENST00000368222.3	-	3	441	c.287G>C	c.(286-288)tGt>tCt	p.C96S	CRABP2_ENST00000368221.1_Missense_Mutation_p.C96S	NM_001199723.1|NM_001878.3	NP_001186652.1|NP_001869.1	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	96					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			endometrium(2)|lung(3)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	CTTCTGCTCACAGACCATTTT	0.562000													9	72					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125876325	125876325	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:125876325C>A	ENST00000393434.2	-	4	738	c.389G>T	c.(388-390)gGg>gTg	p.G130V	ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000393431.2_Missense_Mutation_p.G130V|ALDH1L1_ENST00000455064.2_5'UTR|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.G130V|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.G140V	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	130	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	GGAAAACCCCCCTTTCTTATC	0.592000													6	121					0.00116845	0.00128674	1	1	0
OR4A47	403253	broad.mit.edu	37	11	48510588	48510588	+	Missense_Mutation	SNP	G	G	A	rs150210663		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:48510588G>A	ENST00000446524.1	+	1	320	c.244G>A	c.(244-246)Ggc>Agc	p.G82S		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	82			G -> D (in dbSNP:rs12805819).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G82S(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						ATTGATTTCAGGCTTGTTCTT	0.428000													20	106					0	0	1	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716741	142716741	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:142716741C>T	ENST00000381779.4	-	2	2409	c.2184G>A	c.(2182-2184)gaG>gaA	p.E728E	SLITRK4_ENST00000356928.1_Silent_p.E728E|SLITRK4_ENST00000338017.4_Silent_p.E728E	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	728						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					ATAAATCTTTCTCCTTGTCGG	0.413000													9	79					0	0	1	0	0
FERD3L	222894	broad.mit.edu	37	7	19184717	19184717	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:19184717C>A	ENST00000275461.3	-	1	327	c.269G>T	c.(268-270)gGc>gTc	p.G90V	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	90					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						CTTGGGGCGGCCTAATAGGGA	0.597000													5	32					0.000602214	0.000671534	1	1	0
SCAF8	22828	broad.mit.edu	37	6	155154150	155154150	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:155154150A>G	ENST00000367178.3	+	20	4013	c.3437A>G	c.(3436-3438)cAc>cGc	p.H1146R	SCAF8_ENST00000367186.4_Missense_Mutation_p.H1212R|TIAM2_ENST00000461783.3_5'UTR|SCAF8_ENST00000417268.1_Missense_Mutation_p.H1146R	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	1146	Arg-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						CAAGAAGTTCACAGAGATTTT	0.438000													16	97					0	0	1	0	0
BCAS1	8537	broad.mit.edu	37	20	52645240	52645240	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:52645240C>A	ENST00000395961.3	-	4	580	c.414G>T	c.(412-414)tgG>tgT	p.W138C	BCAS1_ENST00000371435.2_Missense_Mutation_p.W138C|BCAS1_ENST00000371440.3_Missense_Mutation_p.W138C|BCAS1_ENST00000411563.1_Missense_Mutation_p.W41C	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	138						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCGGAAGTGTCCAGCTCTCAC	0.597000													11	83					1.58986e-06	2.00349e-06	1	1	0
MCM7	4176	broad.mit.edu	37	7	99697245	99697245	+	Silent	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:99697245T>A	ENST00000303887.5	-	3	888	c.243A>T	c.(241-243)gtA>gtT	p.V81V	MCM7_ENST00000354230.3_5'UTR|MCM7_ENST00000343023.6_Silent_p.V81V	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	81					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	GCAGCTCTTGTACGGCATCAG	0.532000													24	141					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36221470	36221470	+	Silent	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:36221470G>C	ENST00000222270.7	+	25	5229	c.5229G>C	c.(5227-5229)ctG>ctC	p.L1743L	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Silent_p.L1743L	NM_014727.1	NP_055542.1																					TGGGTACTCTGTCTGATCTCT	0.622000													52	355					0	0	1	0	0
ZNF106	64397	broad.mit.edu	37	15	42743868	42743868	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:42743868T>C	ENST00000263805.4	-	2	859	c.533A>G	c.(532-534)cAt>cGt	p.H178R	ZNF106_ENST00000565611.1_Intron|ZNF106_ENST00000565380.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		AGAATTACTATGGTTGTGAAA	0.473000													8	99					0	0	1	0	0
OR7A5	26659	broad.mit.edu	37	19	14938443	14938443	+	Missense_Mutation	SNP	G	G	T	rs143093089	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:14938443G>T	ENST00000322301.3	-	2	698	c.611C>A	c.(610-612)gCg>gAg	p.A204E	OR7A5_ENST00000601611.1_Intron|OR7A5_ENST00000594432.1_Missense_Mutation_p.A204E			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A204V(1)		breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						ACCCAGCAGCGCAACTGTAAA	0.428000													16	91					3.41278e-10	4.88666e-10	1	1	0
KLHL14	57565	broad.mit.edu	37	18	30267170	30267170	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:30267170G>T	ENST00000359358.4	-	5	1624	c.1186C>A	c.(1186-1188)Cga>Aga	p.R396R		NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	396						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						GGATCATATCGGCTGACAAAA	0.368000													21	137					7.87624e-14	1.19395e-13	1	1	0
STX19	415117	broad.mit.edu	37	3	93733458	93733458	+	Missense_Mutation	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:93733458A>G	ENST00000315099.2	-	2	912	c.656T>C	c.(655-657)cTt>cCt	p.L219P	ARL13B_ENST00000535334.1_Intron|ARL13B_ENST00000471138.1_Intron|ARL13B_ENST00000486562.1_Intron|ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000394222.3_Intron	NM_001001850.2	NP_001001850.1	Q8N4C7	STX19_HUMAN	syntaxin 19	219	t-SNARE coiled-coil homology.				intracellular protein transport|vesicle-mediated transport	membrane	SNAP receptor activity			kidney(2)|large_intestine(2)|lung(4)|prostate(1)	9						CAAATTAACAAGTTCCTTGTG	0.328000													4	66					0	0	1	0	0
GCKR	2646	broad.mit.edu	37	2	27745432	27745432	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:27745432C>G	ENST00000264717.2	+	18	1741	c.1678C>G	c.(1678-1680)Cat>Gat	p.H560D	GCKR_ENST00000424318.2_Missense_Mutation_p.H370D	NM_001486.3	NP_001477.2	Q14397	GCKR_HUMAN	glucokinase (hexokinase 4) regulator	560				H -> R (in Ref. 1; CAA88367).	carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(2)	29	Acute lymphoblastic leukemia(172;0.155)					CATCTCCTGCCATGTCCAGGT	0.517000													26	85					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53432595	53432595	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:53432595C>A	ENST00000549216.1	-	2	126	c.56G>T	c.(55-57)gGg>gTg	p.G19V	ZNF816-ZNF321P_ENST00000313956.4_RNA|ZNF321P_ENST00000391777.3_Missense_Mutation_p.G88V|ZNF816_ENST00000434371.2_Missense_Mutation_p.G88V	NM_001202473.1	NP_001189402.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						TTGCAATGTCCCTGTGTGGAT	0.378000													40	237					9.73076e-26	1.56297e-25	1	1	0
SETBP1	26040	broad.mit.edu	37	18	42530307	42530307	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:42530307G>A	ENST00000282030.5	+	4	1298	c.1002G>A	c.(1000-1002)aaG>aaA	p.K334K		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	334						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		TGGGCAGCAAGAAAAAGTCCA	0.507000									Schinzel-Giedion syndrome				22	85					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33576343	33576343	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:33576343G>T	ENST00000504830.1	-	19	4123	c.3788C>A	c.(3787-3789)aCg>aAg	p.T1263K	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.T1178K	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1263	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.T1263M(2)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						ACGGTTTGCCGTCTTTCCTGA	0.502000										HNSCC(64;0.19)			47	233					5.7616e-29	9.30258e-29	1	1	0
KIF1A	547	broad.mit.edu	37	2	241683419	241683419	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:241683419A>T	ENST00000498729.2	-	33	3770	c.3524T>A	c.(3523-3525)tTc>tAc	p.F1175Y	KIF1A_ENST00000320389.7_Missense_Mutation_p.F1074Y	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	1074					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AAAGACCTCGAAAACAATGGG	0.632000													39	122					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1494859	1494859	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:1494859G>C	ENST00000283415.3	-	3	581	c.449C>G	c.(448-450)tCc>tGc	p.S150C		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	150					phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		CATCACGATGGAGGACATCGT	0.637000													8	67					0	0	1	0	0
SSH2	85464	broad.mit.edu	37	17	27999015	27999015	+	Silent	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:27999015T>C	ENST00000269033.3	-	8	817	c.666A>G	c.(664-666)gaA>gaG	p.E222E	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Silent_p.E249E	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	222					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTGCATTCCATTCATTGACTG	0.468000													29	187					0	0	1	0	0
OR2W5	441932	broad.mit.edu	37	1	247654476	247654476	+	RNA	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:247654476G>C	ENST00000522351.1	+	0	107							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ATCCTGGTGGGCTCTTCTGAT	0.478000													8	56					0	0	1	0	0
P2RY10	27334	broad.mit.edu	37	X	78216960	78216960	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:78216960C>A	ENST00000171757.2	+	4	1223	c.943C>A	c.(943-945)Caa>Aaa	p.Q315K	P2RY10_ENST00000544091.1_Missense_Mutation_p.Q315K	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	315						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						GTTTCGTGACCAACTATCCCG	0.443000													24	60					3.08376e-08	4.13838e-08	1	1	0
CDH10	1008	broad.mit.edu	37	5	24509733	24509733	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:24509733C>A	ENST00000264463.4	-	7	1705	c.1198G>T	c.(1198-1200)Ggc>Tgc	p.G400C		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	400	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATGATTGTGCCCACTTCAATA	0.418000										HNSCC(23;0.051)			9	71					1	1	1	1	0
SPEF2	79925	broad.mit.edu	37	5	35740237	35740237	+	Missense_Mutation	SNP	T	T	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:35740237T>G	ENST00000440995.2	+	23	3183	c.3183T>G	c.(3181-3183)agT>agG	p.S1061R	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.S1066R			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1066					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			ACAGAACAAGTTTCCAGGAGT	0.378000													9	120					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149441320	149441320	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:149441320C>G	ENST00000286301.3	-	12	2010	c.1719G>C	c.(1717-1719)gaG>gaC	p.E573D	CSF1R_ENST00000515239.1_5'UTR	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	573					cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ACTCCCACTTCTCGTTGTAAG	0.557000													21	106					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141536910	141536910	+	Splice_Site	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:141536910A>T	ENST00000350549.3	-	4	939		c.e4+1		PRSS37_ENST00000438520.1_Splice_Site	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37						proteolysis	extracellular region	serine-type endopeptidase activity	p.?(1)		central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						AGATAAGATTACCCCAAAAAT	0.328000													7	72					0	0	1	0	0
FOXF1	2294	broad.mit.edu	37	16	86544300	86544300	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:86544300G>T	ENST00000262426.4	+	1	168	c.125G>T	c.(124-126)gGc>gTc	p.G42V		NM_001451.2	NP_001442.2	Q12946	FOXF1_HUMAN	forkhead box F1	42					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(1)	12						ACCAACGCCGGCATCCGGCGC	0.716000													4	29					0.014758	0.0153781	1	1	0
KIF26A	26153	broad.mit.edu	37	14	104642724	104642724	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:104642724C>A	ENST00000315264.7	+	11	3560	c.3182C>A	c.(3181-3183)gCa>gAa	p.A1061E	KIF26A_ENST00000423312.2_Missense_Mutation_p.A1200E			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1200					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TCGCGGTGGGCATCCGCAGCC	0.726000													3	9					0.004672	0.00498561	1	1	0
DSC3	1825	broad.mit.edu	37	18	28612174	28612174	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:28612174G>T	ENST00000434452.1	-	2	292	c.138C>A	c.(136-138)gaC>gaA	p.D46E	DSC3_ENST00000360428.4_Missense_Mutation_p.D46E	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	46					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CAATTATTTTGTCTGCCTCTA	0.343000													5	33					0.00116845	0.00128674	1	1	0
DDX6	1656	broad.mit.edu	37	11	118636046	118636046	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:118636046T>C	ENST00000264018.4	-	6	822	c.517A>G	c.(517-519)Act>Gct	p.T173A	DDX6_ENST00000534980.1_Missense_Mutation_p.T173A|DDX6_ENST00000526070.2_Missense_Mutation_p.T173A	NM_004397.4	NP_004388.2	P26196	DDX6_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 6	173	Helicase ATP-binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|RNA-induced silencing complex|stress granule	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding|RNA helicase activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)	13	all_hematologic(175;0.0839)	Renal(330;0.0183)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)|Hepatocellular(160;0.0893)|Breast(348;0.0979)|all_hematologic(192;0.103)		OV - Ovarian serous cystadenocarcinoma(223;3.39e-06)|BRCA - Breast invasive adenocarcinoma(274;3.4e-05)|Colorectal(284;0.0377)		AGTTCTCTAGTGGGAACAATC	0.413000			T	IGH@	B-NHL								46	247					0	0	1	0	0
DACH2	117154	broad.mit.edu	37	X	86067970	86067970	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:86067970G>T	ENST00000373131.1	+	7	1476	c.1313G>T	c.(1312-1314)aGt>aTt	p.S438I	DACH2_ENST00000510272.1_Missense_Mutation_p.S232I|DACH2_ENST00000508860.1_Missense_Mutation_p.S284I|DACH2_ENST00000373125.4_Missense_Mutation_p.S451I|DACH2_ENST00000477378.2_3'UTR	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	451					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TTTGCTGATAGTCTGTCCTCC	0.403000													3	12					6.4e-05	7.51681e-05	1	1	0
SOS1	6654	broad.mit.edu	37	2	39213261	39213261	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:39213261G>A	ENST00000426016.1	-	24	3792	c.3706C>T	c.(3706-3708)Ccc>Tcc	p.P1236S	SOS1_ENST00000402219.2_Missense_Mutation_p.P1236S|SOS1_ENST00000395038.2_Missense_Mutation_p.P1221S			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	1236					apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				CCCAAAGGGGGAGGTTGGAGA	0.522000									Noonan syndrome				15	131					0	0	1	0	0
CYP39A1	51302	broad.mit.edu	37	6	46605711	46605711	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:46605711G>T	ENST00000275016.2	-	4	696	c.493C>A	c.(493-495)Ctc>Atc	p.L165I		NM_016593.3	NP_057677.2	Q9NYL5	CP39A_HUMAN	cytochrome P450, family 39, subfamily A, polypeptide 1	165					bile acid biosynthetic process|bile acid catabolic process|digestion|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	24-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity		EIF3K/CYP39A1(2)	NS(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)	21						GGATAAAGGAGATGTCTACAA	0.343000													7	42					8.12818e-05	9.4727e-05	1	1	0
ZNF804B	219578	broad.mit.edu	37	7	88965825	88965825	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:88965825C>A	ENST00000333190.4	+	4	4138	c.3529C>A	c.(3529-3531)Cat>Aat	p.H1177N		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1177						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			CCTATCAAAGCATCTTCGAGT	0.468000										HNSCC(36;0.09)			19	86					0.00074312	0.000825689	1	1	0
SNRPC	6631	broad.mit.edu	37	6	34741303	34741303	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:34741303A>T	ENST00000374017.3	+	5	786	c.499A>T	c.(499-501)Atg>Ttg	p.M167L	SNRPC_ENST00000474635.1_3'UTR|SNRPC_ENST00000244520.5_Missense_Mutation_p.M146L|SNRPC_ENST00000374018.1_Missense_Mutation_p.M105L			P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	146					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)	6						TGCCCGTCCCATGATGGTGCC	0.542000													7	81					0	0	1	0	0
CELF5	60680	broad.mit.edu	37	19	3281300	3281300	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:3281300C>G	ENST00000541430.2	+	6	743	c.707C>G	c.(706-708)tCc>tGc	p.S236C	CELF5_ENST00000292672.2_Missense_Mutation_p.S236C	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	236					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						CTGACGCCGTCCCTCACATTG	0.652000													15	94					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167713	140167713	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:140167713C>A	ENST00000504120.2	+	1	1838	c.1838C>A	c.(1837-1839)cCg>cAg	p.P613Q	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000378133.3_Missense_Mutation_p.P613Q	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACTGCAGCCGGCAGCAGGC	0.682000													17	95					6.94344e-10	9.78394e-10	1	1	0
CD1E	913	broad.mit.edu	37	1	158324281	158324281	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:158324281G>T	ENST00000368160.3	+	2	173	c.173G>T	c.(172-174)tGg>tTg	p.W58L	CD1E_ENST00000368164.3_Intron|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000464822.1_Intron|CD1E_ENST00000368155.3_Missense_Mutation_p.W58L|CD1E_ENST00000368156.1_Missense_Mutation_p.W58L|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368161.3_Missense_Mutation_p.W58L|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368165.3_Missense_Mutation_p.W58L|CD1E_ENST00000368163.3_Missense_Mutation_p.W58L|CD1E_ENST00000368167.3_Missense_Mutation_p.W58L|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000444681.2_Intron|CD1E_ENST00000434258.1_Missense_Mutation_p.W56L	NM_001042583.2	NP_001036048.1	P15812	CD1E_HUMAN	CD1e molecule	58					antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					GGCTCAGGATGGCTGGGTGAC	0.562000													5	103					0.014758	0.0153781	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141819675	141819675	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:141819675A>T	ENST00000389484.3	-	8	2152	c.1181T>A	c.(1180-1182)gTg>gAg	p.V394E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	394					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CACTACTCCCACATAGTCCAA	0.403000										TSP Lung(27;0.18)			9	132					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88962752	88962752	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:88962752C>A	ENST00000333190.4	+	4	1065	c.456C>A	c.(454-456)ccC>ccA	p.P152P		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	152						intracellular	zinc ion binding	p.P152P(1)		NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			GAATTTTCCCCATTAAGAATG	0.408000										HNSCC(36;0.09)			8	47					0.0381472	0.0392878	1	1	0
TRAV21	28662	broad.mit.edu	37	14	22521193	22521193	+	RNA	SNP	A	A	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:22521193A>G	ENST00000390449.3	+	0	221																											TATTCAGTCAAGTCAGAGAGA	0.463000													7	38					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128351709	128351709	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:128351709C>A	ENST00000262462.4	+	5	2111	c.1101C>A	c.(1099-1101)agC>agA	p.S367R	SLC27A6_ENST00000395266.1_Missense_Mutation_p.S367R|SLC27A6_ENST00000506176.1_Missense_Mutation_p.S367R			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	367					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		CCGAATCAAGCATATCTTTCA	0.353000													20	131					3.08376e-08	4.13838e-08	1	1	0
ZNF549	256051	broad.mit.edu	37	19	58048905	58048905	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:58048905C>G	ENST00000376233.3	+	4	714	c.533C>G	c.(532-534)tCa>tGa	p.S178*	ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000240719.3_Nonsense_Mutation_p.S165*|ZNF549_ENST00000602149.1_Intron|ZNF550_ENST00000601415.1_Intron	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTCCTCTGTCAGACAATCTT	0.478000													7	67					0	0	1	0	0
AP1G1	164	broad.mit.edu	37	16	71790027	71790027	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:71790027C>A	ENST00000299980.4	-	12	1565	c.1124G>T	c.(1123-1125)gGg>gTg	p.G375V	AP1G1_ENST00000423132.2_Missense_Mutation_p.G378V|AP1G1_ENST00000393512.3_Missense_Mutation_p.G378V|AP1G1_ENST00000433195.2_Missense_Mutation_p.G398V|AP1G1_ENST00000569748.1_Missense_Mutation_p.G375V	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	375					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				GATATTATTCCCATTTACCAG	0.378000													12	75					2.68362e-12	3.94276e-12	1	1	0
PLEKHH1	57475	broad.mit.edu	37	14	68040045	68040045	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr14:68040045C>T	ENST00000329153.5	+	12	1913	c.1781C>T	c.(1780-1782)aCg>aTg	p.T594M		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	594	PH 1.					cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CAGGTGAAGACGTGGAAGAGG	0.557000													12	49					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201294890	201294890	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:201294890C>T	ENST00000263946.3	+	13	2344	c.2093C>T	c.(2092-2094)cCc>cTc	p.P698L	PKP1_ENST00000367324.3_Missense_Mutation_p.P677L|PKP1_ENST00000352845.3_Missense_Mutation_p.P698L	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	698					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						AGTGCCTCACCCAAGGCCGCA	0.597000													14	44					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164758731	164758731	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:164758731T>A	ENST00000264382.3	-	18	2218	c.2156A>T	c.(2155-2157)cAt>cTt	p.H719L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	719	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TACTCACTCATGAAGAACTGG	0.323000										HNSCC(35;0.089)			9	146					0	0	1	0	0
C20orf194	25943	broad.mit.edu	37	20	3324334	3324334	+	Silent	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:3324334T>A	ENST00000252032.9	-	9	901	c.834A>T	c.(832-834)atA>atT	p.I278I		NM_001009984.2	NP_001009984.1	Q5TEA3	CT194_HUMAN	chromosome 20 open reading frame 194	278										NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	39						TGTTTTCAGTTATATGGCTAG	0.393000													72	434					0	0	1	0	0
BCHE	590	broad.mit.edu	37	3	165548018	165548018	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:165548018C>A	ENST00000264381.3	-	2	970	c.804G>T	c.(802-804)agG>agT	p.R268S	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	268					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	ACGTTCTGTTCCTAGCTTCAT	0.398000													13	117					4.36969e-10	6.19956e-10	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10466108	10466108	+	Missense_Mutation	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:10466108C>T	ENST00000382483.3	-	4	5723	c.5500G>A	c.(5500-5502)Ggc>Agc	p.G1834S		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1834					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GCCTCTATGCCTTCGGCCCCA	0.637000													45	262					0	0	1	0	0
OR6K2	81448	broad.mit.edu	37	1	158669643	158669643	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:158669643T>A	ENST00000359610.2	-	1	843	c.800A>T	c.(799-801)tAc>tTc	p.Y267F		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					GAACAAAGAGTAGGTGGCAGA	0.458000													10	88					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77376684	77376684	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:77376684G>T	ENST00000451710.3	-	27	4950	c.4713C>A	c.(4711-4713)gtC>gtA	p.V1571V	TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000449912.2_Silent_p.V1566V|TRPM6_ENST00000360774.1_Silent_p.V1571V|TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000376864.4_Silent_p.V1571V|TRPM6_ENST00000361255.3_Silent_p.V1566V			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1571					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TTTTCGCTTTGACCCATGCTC	0.413000													6	65					3.59834e-05	4.26571e-05	1	1	0
GOT2	2806	broad.mit.edu	37	16	58757763	58757763	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:58757763G>A	ENST00000245206.5	-	2	261	c.133C>T	c.(133-135)Ctg>Ttg	p.L45L	GOT2_ENST00000564400.1_5'UTR|GOT2_ENST00000434819.2_Silent_p.L45L	NM_002080.2	NP_002071.2	P00505	AATM_HUMAN	glutamic-oxaloacetic transaminase 2, mitochondrial	45					aspartate catabolic process|fatty acid transport|gluconeogenesis|response to ethanol	mitochondrial matrix|plasma membrane	L-aspartate:2-oxoglutarate aminotransferase activity|protein binding|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|prostate(2)|skin(1)	22					L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GTGACTCCCAGAATGGGATCT	0.468000													9	142					0	0	1	0	0
PDHA2	5161	broad.mit.edu	37	4	96761553	96761553	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr4:96761553C>A	ENST00000295266.4	+	1	315	c.252C>A	c.(250-252)ttC>ttA	p.F84L		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	84					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity	p.F84F(1)		NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	AACAGAAATTCATTCGCGGTT	0.517000													11	110					2.68362e-12	3.94276e-12	1	1	0
SLK	9748	broad.mit.edu	37	10	105759647	105759647	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr10:105759647C>G	ENST00000369755.3	+	7	1350	c.805C>G	c.(805-807)Cta>Gta	p.L269V	SLK_ENST00000335753.4_Missense_Mutation_p.L269V	NM_014720.2	NP_055535.2	Q9H2G2	SLK_HUMAN	STE20-like kinase	269	Protein kinase.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			kidney(1)|lung(1)|ovary(2)|skin(2)|stomach(2)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TAAGGACTTTCTAAAGAAATG	0.284000													6	31					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158627383	158627383	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:158627383C>A	ENST00000368148.3	-	19	2869	c.2689G>T	c.(2689-2691)Gcc>Tcc	p.A897S	SPTA1_ENST00000368147.3_Missense_Mutation_p.A897S	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	897					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TGGACATTGGCTTCAAGATCA	0.468000													43	153					5.44703e-19	8.59328e-19	1	1	0
CX3CR1	1524	broad.mit.edu	37	3	39307161	39307161	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:39307161C>T	ENST00000541347.1	-	2	1079	c.840G>A	c.(838-840)acG>acA	p.T280T	CX3CR1_ENST00000358309.3_Silent_p.T312T|CX3CR1_ENST00000399220.2_Silent_p.T280T|CX3CR1_ENST00000542107.1_Silent_p.T280T	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	280			T -> M (common polymorphism in Caucasian population; dbSNP:rs3732378).		cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		TAAATGCAACCGTCTCAGTCA	0.473000													28	135					0	0	1	0	0
OR10W1	81341	broad.mit.edu	37	11	58035306	58035306	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:58035306G>A	ENST00000395079.2	-	1	426	c.25C>T	c.(25-27)Ccc>Tcc	p.P9S		NM_207374.3	NP_997257.2	Q8NGF6	O10W1_HUMAN	olfactory receptor, family 10, subfamily W, member 1	9					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P9S(1)		kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(1)	26		Breast(21;0.0589)				GGGCAGGAGGGATAGGCCAGG	0.453000													9	49					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325553	150325553	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:150325553G>C	ENST00000328902.5	-	3	349	c.133C>G	c.(133-135)Ctc>Gtc	p.L45V	GIMAP6_ENST00000493969.1_Intron	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	45							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTCCCCATGAGAATGAGCCTC	0.527000													31	368					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69726114	69726114	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:69726114C>G	ENST00000349945.1	+	14	3656	c.2104C>G	c.(2104-2106)Ctg>Gtg	p.L702V	NFAT5_ENST00000393742.2_Missense_Mutation_p.L702V|NFAT5_ENST00000354436.2_Missense_Mutation_p.L778V|NFAT5_ENST00000566899.1_Missense_Mutation_p.L702V|NFAT5_ENST00000567239.1_Missense_Mutation_p.L795V|NFAT5_ENST00000432919.1_Missense_Mutation_p.L796V	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	778					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TATTCAGCAGCTGCAAGCAGG	0.438000													21	107					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	C	A	rs28934575		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:7577548C>A	ENST00000420246.2	-	7	865	c.733G>T	c.(733-735)Ggc>Tgc	p.G245C	TP53_ENST00000359597.4_Missense_Mutation_p.G245C|TP53_ENST00000269305.4_Missense_Mutation_p.G245C|TP53_ENST00000413465.2_Missense_Mutation_p.G245C|TP53_ENST00000445888.2_Missense_Mutation_p.G245C|TP53_ENST00000455263.2_Missense_Mutation_p.G245C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(304)|p.G245C(59)|p.G245R(10)|p.G152S(8)|p.0?(8)|p.?(5)|p.G152C(4)|p.G244_M246>V(3)|p.G245N(2)|p.G245fs*2(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.G245fs*22(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577000	G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKLMS1_SOFT_TISSUE)|G245S(SKMEL2_SKIN)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	49					0.0167234	0.0173677	1	1	0
HSPG2	3339	broad.mit.edu	37	1	22176868	22176868	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:22176868C>A	ENST00000374695.3	-	56	7361	c.7282G>T	c.(7282-7284)Ggc>Tgc	p.G2428C	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2428	Ig-like C2-type 9.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGCACTGAGCCCGCAGGCTCA	0.677000													4	15					1.23904e-05	1.48877e-05	1	1	0
ZNF224	7767	broad.mit.edu	37	19	44610912	44610912	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:44610912G>T	ENST00000336976.6	+	6	853	c.599G>T	c.(598-600)gGa>gTa	p.G200V	AC084219.4_ENST00000592946.1_RNA	NM_013398.2	NP_037530.2	Q9NZL3	ZN224_HUMAN	zinc finger protein 224	200					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19		Prostate(69;0.0435)				GTCCACATGGGAGAGAAATGC	0.428000													31	209					1.16021e-09	1.62011e-09	1	1	0
COL22A1	169044	broad.mit.edu	37	8	139809090	139809090	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:139809090G>T	ENST00000303045.6	-	12	2014	c.1568C>A	c.(1567-1569)cCt>cAt	p.P523H	COL22A1_ENST00000435777.1_Missense_Mutation_p.P523H	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	523	Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TTGGCCAAAAGGTCCTATGCC	0.463000										HNSCC(7;0.00092)			12	199					4.3838e-07	5.61561e-07	1	1	0
LCE3D	84648	broad.mit.edu	37	1	152552371	152552371	+	Silent	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:152552371G>T	ENST00000368787.3	-	2	98	c.42C>A	c.(40-42)ccC>ccA	p.P14P		NM_032563.1	NP_115952.1	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	14					keratinization					breast(1)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|stomach(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		AGGGACACTTGGGTGGGGGTT	0.567000													33	120					1.06647e-15	1.64073e-15	1	1	0
IFNA16	3449	broad.mit.edu	37	9	21217147	21217147	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:21217147A>T	ENST00000380216.1	-	1	163	c.158T>A	c.(157-159)cTg>cAg	p.L53Q		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	53					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCTGTCCTTCAGGCAGGAGAA	0.512000													29	162					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29649572	29649572	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:29649572T>A	ENST00000318184.5	-	2	99	c.100A>T	c.(100-102)Agt>Tgt	p.S34C		NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	34					proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GGTTCCTTACTTTTCATGTTG	0.443000													15	94					0	0	1	0	0
NUP155	9631	broad.mit.edu	37	5	37305173	37305173	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:37305173C>A	ENST00000231498.3	-	26	3246	c.3043G>T	c.(3043-3045)Gaa>Taa	p.E1015*	NUP155_ENST00000381843.2_Nonsense_Mutation_p.E956*|NUP155_ENST00000513532.1_Nonsense_Mutation_p.E951*|NUP155_ENST00000502533.1_5'UTR	NM_153485.1	NP_705618.1	O75694	NU155_HUMAN	nucleoporin 155kDa	1015					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			endometrium(1)|kidney(16)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	62	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGTCCTGCTTCTTCATTACTC	0.423000													16	156					6.31663e-08	8.42217e-08	1	1	0
FCRL1	115350	broad.mit.edu	37	1	157773696	157773696	+	Silent	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:157773696G>A	ENST00000358292.3	-	3	309	c.258C>T	c.(256-258)tgC>tgT	p.C86C	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000368176.3_Silent_p.C86C|FCRL1_ENST00000491942.1_Silent_p.C86C	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	86	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TCTGTGCCTCGCACCAGTATG	0.572000													15	101					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36768520	36768520	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:36768520C>A	ENST00000399881.3	+	22	2441	c.2404C>A	c.(2404-2406)Ccc>Acc	p.P802T		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	802						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TGTCTTGTCCCCCCCACCCCA	0.527000													14	51					0.00316338	0.00342884	1	1	0
SLC22A14	9389	broad.mit.edu	37	3	38348841	38348841	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:38348841A>T	ENST00000273173.4	+	2	704	c.613A>T	c.(613-615)Act>Tct	p.T205S	SLC22A14_ENST00000448498.1_Missense_Mutation_p.T205S	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	205						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		CAGGCTCATAACTGACAAGTG	0.547000													7	100					0	0	1	0	0
RBM27	54439	broad.mit.edu	37	5	145640433	145640433	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:145640433G>T	ENST00000265271.5	+	12	2031	c.1865G>T	c.(1864-1866)aGc>aTc	p.S622I	RBM27_ENST00000506502.1_Missense_Mutation_p.S567I	NM_018989.1	NP_061862.1	Q9P2N5	RBM27_HUMAN	RNA binding motif protein 27	622	RRM.				mRNA processing	cytoplasm|nuclear speck	nucleotide binding|RNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(3)|endometrium(4)|kidney(5)|large_intestine(7)|liver(2)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAACACTTCAGCAAATTTGGA	0.378000													20	148					1.9806e-07	2.5852e-07	1	1	0
ZNF770	54989	broad.mit.edu	37	15	35274610	35274610	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:35274610C>A	ENST00000356321.4	-	3	1370	c.1026G>T	c.(1024-1026)aaG>aaT	p.K342N		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	342					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		CACGCTTAAGCTTGGCCAAGA	0.333000													3	33					0.115264	0.118122	1	1	0
CDH18	1016	broad.mit.edu	37	5	19612606	19612606	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:19612606C>A	ENST00000507958.1	-	8	1738	c.748G>T	c.(748-750)Gga>Tga	p.G250*	CDH18_ENST00000502796.1_Nonsense_Mutation_p.G250*|CDH18_ENST00000506372.1_Nonsense_Mutation_p.G250*|CDH18_ENST00000382275.1_Nonsense_Mutation_p.G250*|CDH18_ENST00000511273.1_Nonsense_Mutation_p.G250*|CDH18_ENST00000274170.4_Nonsense_Mutation_p.G250*			Q13634	CAD18_HUMAN	cadherin 18, type 2	250	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GTTGTAGATCCTGAAAGCCCT	0.418000													4	58					0.014758	0.0153781	1	1	0
CPQ	10404	broad.mit.edu	37	8	97797154	97797154	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:97797154G>T	ENST00000220763.5	+	2	239	c.29G>T	c.(28-30)gGt>gTt	p.G10V		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	10					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										GCATTTTTCGGTGGTGTTCAC	0.338000													13	92					0.000151284	0.000174993	1	1	0
RNASET2	8635	broad.mit.edu	37	6	167352485	167352485	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:167352485C>A	ENST00000366855.6	-	7	905	c.230G>T	c.(229-231)tGg>tTg	p.W77L	RNASET2_ENST00000508775.1_Missense_Mutation_p.W115L|RP11-514O12.4_ENST00000507747.1_Missense_Mutation_p.G96W|RNASET2_ENST00000476238.2_Missense_Mutation_p.W115L|RNASET2_ENST00000496851.2_5'UTR			O00584	RNT2_HUMAN	ribonuclease T2	115					RNA catabolic process	extracellular region	ribonuclease T2 activity|RNA binding			large_intestine(4)|lung(4)	8		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;1.53e-19)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00665)		ATGCTTTTCCCACTCATGCTT	0.527000													16	85					0.00316338	0.00342884	1	1	0
KCNT2	343450	broad.mit.edu	37	1	196302978	196302978	+	Splice_Site	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:196302978C>A	ENST00000367433.5	-	17	2097	c.1997_splice	c.e17+1	p.E666_splice	KCNT2_ENST00000367431.4_Splice_Site_p.E616_splice|KCNT2_ENST00000451324.2_Splice_Site_p.E277_splice|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Splice_Site_p.E666_splice			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	666						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TGAACATACTCTAAGTTTGAA	0.353000													7	32					8.12818e-05	9.4727e-05	1	1	0
HTR1F	3355	broad.mit.edu	37	3	88040607	88040607	+	Missense_Mutation	SNP	A	A	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr3:88040607A>T	ENST00000319595.4	+	1	762	c.708A>T	c.(706-708)aaA>aaT	p.K236N		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	236					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	GTGGTGAGAAAAGCACTAAAT	0.393000													6	98					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	5968930	5968930	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr9:5968930C>A	ENST00000399933.3	-	3	1300	c.1301G>T	c.(1300-1302)tGt>tTt	p.C434F	KIAA2026_ENST00000381461.2_Missense_Mutation_p.C434F	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	434										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CACAAAGTCACAAAGACCCTT	0.368000													3	20					0.004672	0.00498561	1	1	0
AP1G1	164	broad.mit.edu	37	16	71790028	71790028	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr16:71790028C>A	ENST00000299980.4	-	12	1564	c.1123G>T	c.(1123-1125)Ggg>Tgg	p.G375W	AP1G1_ENST00000423132.2_Missense_Mutation_p.G378W|AP1G1_ENST00000393512.3_Missense_Mutation_p.G378W|AP1G1_ENST00000433195.2_Missense_Mutation_p.G398W|AP1G1_ENST00000569748.1_Missense_Mutation_p.G375W	NM_001128.5	NP_001119.3	O43747	AP1G1_HUMAN	adaptor-related protein complex 1, gamma 1 subunit	375					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|recycling endosome	kinesin binding|protein transporter activity			breast(1)|endometrium(8)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|urinary_tract(1)	28		Ovarian(137;0.125)				ATATTATTCCCATTTACCAGG	0.378000													12	75					2.68362e-12	3.94276e-12	1	1	0
ADCY8	114	broad.mit.edu	37	8	131964216	131964216	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:131964216C>A	ENST00000286355.5	-	3	3231	c.1139G>T	c.(1138-1140)cGg>cTg	p.R380L	ADCY8_ENST00000377928.3_Missense_Mutation_p.R380L	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	380					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GACAACAAACCGGGGGAGCAC	0.547000										HNSCC(32;0.087)			7	79					2.0095e-06	2.51187e-06	1	1	0
CSTF2	1478	broad.mit.edu	37	X	100075409	100075409	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:100075409G>A	ENST00000415585.2	+	1	26	c.4G>A	c.(4-6)Gcg>Acg	p.A2T	CSTF2_ENST00000372972.2_Missense_Mutation_p.A2T|CSTF2_ENST00000486615.1_3'UTR			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	2					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						CAGAGCTATGGCGGGTTTGAC	0.597000													11	18					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678389	88678389	+	Missense_Mutation	SNP	G	G	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:88678389G>C	ENST00000394480.1	-	10	1468	c.1147C>G	c.(1147-1149)Cca>Gca	p.P383A	NTRK3_ENST00000317501.3_Missense_Mutation_p.P383A|NTRK3_ENST00000558676.1_Missense_Mutation_p.P383A|NTRK3_ENST00000355254.2_Missense_Mutation_p.P383A|NTRK3_ENST00000557856.1_Missense_Mutation_p.P383A|NTRK3_ENST00000360948.2_Missense_Mutation_p.P383A|NTRK3_ENST00000540489.2_Missense_Mutation_p.P383A|NTRK3_ENST00000542733.2_Missense_Mutation_p.P285A|NTRK3_ENST00000357724.2_Missense_Mutation_p.P383A	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	383					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTGCCCAGTGGGTTTTTGGCA	0.527000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			13	110					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382863	22382863	+	Missense_Mutation	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:22382863C>A	ENST00000328795.4	+	1	482	c.391C>A	c.(391-393)Cac>Aac	p.H131N	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CCGGCCTCTGCACTGTTCAAC	0.522000													11	334					0.010729	0.0113322	1	1	0
NTNG1	22854	broad.mit.edu	37	1	107867376	107867376	+	Missense_Mutation	SNP	T	T	C			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:107867376T>C	ENST00000370067.1	+	3	1346	c.719T>C	c.(718-720)aTg>aCg	p.M240T	NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370066.1_Missense_Mutation_p.M240T|NTNG1_ENST00000370068.1_Missense_Mutation_p.M240T|NTNG1_ENST00000370070.2_Missense_Mutation_p.M240T|NTNG1_ENST00000370071.2_Missense_Mutation_p.M240T|NTNG1_ENST00000370074.4_Missense_Mutation_p.M240T|NTNG1_ENST00000370072.3_Missense_Mutation_p.M240T|NTNG1_ENST00000370073.2_Missense_Mutation_p.M240T|NTNG1_ENST00000542803.1_Missense_Mutation_p.M240T|NTNG1_ENST00000370061.3_Missense_Mutation_p.M240T|NTNG1_ENST00000370065.1_Missense_Mutation_p.M240T			Q9Y2I2	NTNG1_HUMAN	netrin G1	240	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CTACGCAATATGGCTTCCCTC	0.443000													10	64					0	0	1	0	0
WNT10A	80326	broad.mit.edu	37	2	219754758	219754758	+	Silent	SNP	C	C	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:219754758C>T	ENST00000258411.3	+	3	1062	c.429C>T	c.(427-429)caC>caT	p.H143H	WNT10A_ENST00000483911.1_3'UTR	NM_025216.2	NP_079492.2	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family, member 10A	143			H -> Y (in EDA).		anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|cervix(1)|endometrium(2)|lung(6)|skin(2)	12		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGTGGTGCACGCCGTGTCCA	0.622000													18	72					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57188044	57188044	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:57188044G>T	ENST00000331162.4	-	5	1348	c.1078C>A	c.(1078-1080)Caa>Aaa	p.Q360K		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	360					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CTAAAGGCTTGGCCACATTCT	0.443000													5	37					2.31682e-05	2.76237e-05	1	1	0
HSD3B2	3284	broad.mit.edu	37	1	119962112	119962112	+	Missense_Mutation	SNP	T	T	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:119962112T>A	ENST00000543831.1	+	3	463	c.214T>A	c.(214-216)Tgc>Agc	p.C72S	HSD3B2_ENST00000471656.1_3'UTR|HSD3B2_ENST00000369416.3_Missense_Mutation_p.C72S	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	72					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GAAAAGAGCCTGCCAGGACGT	0.488000													13	66					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	56047342	56047342	+	Silent	SNP	C	C	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:56047342C>A	ENST00000244728.5	-	2	472	c.75G>T	c.(73-75)ggG>ggT	p.G25G	COL21A1_ENST00000535941.1_Silent_p.G25G|COL21A1_ENST00000370819.1_Silent_p.G25G	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	25					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ATCTTACTTCCCCATCTTCAG	0.343000													4	13					0.014758	0.0153781	1	1	0
AMY2A	279	broad.mit.edu	37	1	104160684	104160684	+	Missense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:104160684G>A	ENST00000414303.2	+	2	341	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K		NM_000699.2	NP_000690.1	P04746	AMYP_HUMAN	amylase, alpha 2A (pancreatic)	93					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			endometrium(3)|kidney(1)|large_intestine(5)|liver(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	AAATGAAGATGAATTTAGAAA	0.343000													16	181					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156934092	156934092	+	Missense_Mutation	SNP	G	G	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:156934092G>T	ENST00000257527.4	-	10	1040	c.962C>A	c.(961-963)tCt>tAt	p.S321Y	ADAM19_ENST00000394020.1_Missense_Mutation_p.S323Y|ADAM19_ENST00000430702.2_Missense_Mutation_p.S54Y|ADAM19_ENST00000517905.1_Missense_Mutation_p.S321Y	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	321	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTGGTACACAGAGCACATGGC	0.602000													10	66					1.76689e-08	2.38665e-08	1	1	0
HELZ	9931	broad.mit.edu	37	17	65120094	65120094	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:65120094G>A	ENST00000358691.5	-	25	3590	c.3424C>T	c.(3424-3426)Cag>Tag	p.Q1142*	HELZ_ENST00000580168.1_Nonsense_Mutation_p.Q1143*	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CCATCATTCTGGAAGTGATCA	0.323000													9	87					0	0	1	0	0
SMG9	56006	broad.mit.edu	37	19	44244333	44244333	+	Missense_Mutation	SNP	C	C	G			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:44244333C>G	ENST00000601170.1	-	7	1053	c.739G>C	c.(739-741)Gaa>Caa	p.E247Q	SMG9_ENST00000270066.6_Missense_Mutation_p.E247Q			Q9H0W8	SMG9_HUMAN	SMG9 nonsense mediated mRNA decay factor	247					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	intracellular	protein binding			kidney(1)|large_intestine(5)|liver(1)|lung(7)|pancreas(1)|prostate(2)|urinary_tract(2)	19						CCCCCTCGTTCCTTCATTTCA	0.567000													11	103					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507479	74507479	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:74507479delG	ENST00000354431.4	-	7	1327	c.1136delC	c.(1135-1137)ctfs	p.P379fs	LRRIQ3_ENST00000395089.1_Frame_Shift_Del_p.P379fs	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	379										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						AGGATATGCAGGAAAAAAATG	0.348													14	82	---	---	---	---					
RASAL2	9462	broad.mit.edu	37	1	178427453	178427453	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr1:178427453delC	ENST00000448150.3	+	14	3811	c.2993delC	c.(2992-2994)gcfs	p.A998fs	RASAL2_ENST00000367649.3_Frame_Shift_Del_p.A1009fs|RASAL2_ENST00000462775.1_Frame_Shift_Del_p.A868fs	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	868					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						ACTGGGCAGGCCCAGATCCGA	0.557													8	99	---	---	---	---					
CAPG	822	broad.mit.edu	37	2	85628406	85628406	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr2:85628406delG	ENST00000263867.4	-	5	647	c.398delC	c.(397-399)cafs	p.P133fs	CAPG_ENST00000409670.1_Frame_Shift_Del_p.P133fs|CAPG_ENST00000409724.1_Frame_Shift_Del_p.P133fs|CAPG_ENST00000409921.1_Frame_Shift_Del_p.P133fs|CAPG_ENST00000483659.1_5'UTR	NM_001256140.1|NM_001747.3	NP_001243069.1|NP_001738.2	P40121	CAPG_HUMAN	capping protein (actin filament), gelsolin-like	133					barbed-end actin filament capping|protein complex assembly	F-actin capping protein complex|melanosome|nuclear membrane|nucleolus	actin binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)	11						GATGGCAGCTGGGGCTCCTGT	0.587													10	117	---	---	---	---					
PAPD7	11044	broad.mit.edu	37	5	6755013	6755014	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:6755013_6755014delAC	ENST00000230859.6	+	13	1713_1714	c.1584_1585delAC	c.(1582-1587)aaacfs	p.KH528fs		NM_001171805.1|NM_001171806.1|NM_006999.4	NP_001165276.1|NP_001165277.1|NP_008930.1	Q5XG87	PAPD7_HUMAN	PAP associated domain containing 7	528					cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			cervix(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GGAGGAAAAAACACACACACAC	0.653													7	70	---	---	---	---					
CDH10	1008	broad.mit.edu	37	5	24593369	24593370	+	Splice_Site	INS	-	-	T			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:24593369_24593370insT	ENST00000264463.4	-	2	737_738	c.231_splice	c.e2+1	p.T77_splice	RP11-116O11.1_ENST00000510391.1_RNA	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	77	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.K77N(1)|p.?(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ACAAGCTTACCTTGCCTACGTA	0.322										HNSCC(23;0.051)			16	149	---	---	---	---					
CTD-2503O16.4	0	broad.mit.edu	37	5	74225818	74225818	+	RNA	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr5:74225818delG	ENST00000505200.1	-	0	335																											ACGTGATGTTGGAGAATTATA	0.448													20	101	---	---	---	---					
C6orf223	221416	broad.mit.edu	37	6	43970504	43970506	+	In_Frame_Del	DEL	GCG	GCG	-	rs72369323		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:43970504_43970506delGCG	ENST00000336600.5	+	4	390_392	c.370_372delGCG	c.(370-372)del	p.A132del	C6orf223_ENST00000448947.2_3'UTR|RP5-1120P11.1_ENST00000422059.1_RNA|RP5-1120P11.1_ENST00000607590.1_RNA|C6orf223_ENST00000439969.2_3'UTR	NM_001171992.1|NM_153246.4	NP_001165463.1|NP_694978.2	Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	132	Ala-rich.			A -> AA (in Ref. 2; AAH32706).						central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			GGTAGAGCGCgcggcggcggcgg	0.773													3	4	---	---	---	---					
MYO6	4646	broad.mit.edu	37	6	76599857	76599858	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:76599857_76599858insA	ENST00000369981.3	+	26	3021_3022	c.2742_2743insA	c.(2740-2745)caaaaafs	p.QK914fs	MYO6_ENST00000369975.1_Frame_Shift_Ins_p.QK914fs|MYO6_ENST00000369977.3_Frame_Shift_Ins_p.QK914fs|MYO6_ENST00000369985.4_Frame_Shift_Ins_p.QK914fs			Q9UM54	MYO6_HUMAN	myosin VI	914					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding	p.K917fs*10(1)		breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		GTGCATTACAGAAAAAAAAACA	0.381													7	97	---	---	---	---					
ARHGAP18	93663	broad.mit.edu	37	6	129901237	129901238	+	Frame_Shift_Ins	INS	-	-	A			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr6:129901237_129901238insA	ENST00000368149.2	-	14	1965_1966	c.1877_1878insT	c.(1876-1878)ttafs	p.L626fs	ARHGAP18_ENST00000463225.1_5'UTR	NM_033515.2	NP_277050.2	Q8N392	RHG18_HUMAN	Rho GTPase activating protein 18	626					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(2)|endometrium(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(3)	18				OV - Ovarian serous cystadenocarcinoma(136;0.0621)|GBM - Glioblastoma multiforme(226;0.0638)|all cancers(137;0.074)		CAATTTCATACAAAAAAACTTC	0.342													11	56	---	---	---	---					
PCLO	27445	broad.mit.edu	37	7	82583166	82583166	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr7:82583166delC	ENST00000423517.2	-	5	7440	c.7103delG	c.(7102-7104)gtfs	p.G2368fs	PCLO_ENST00000333891.8_Frame_Shift_Del_p.G2368fs	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2299	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTTTTCCTGACCAAAGGTCTC	0.428													11	56	---	---	---	---					
ZFPM2	23414	broad.mit.edu	37	8	106813948	106813948	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr8:106813948delG	ENST00000407775.2	+	8	1888	c.1638delG	c.(1636-1638)aafs	p.K546fs	ZFPM2_ENST00000517361.1_Frame_Shift_Del_p.K414fs|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000520492.1_Frame_Shift_Del_p.K414fs|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000378472.4_Frame_Shift_Del_p.K277fs|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	546					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			TGATGCCCAAGGGGGCTACTT	0.453													10	171	---	---	---	---					
TECTA	7007	broad.mit.edu	37	11	121058632	121058632	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr11:121058632delG	ENST00000392793.1	+	21	6362	c.6091delG	c.(6091-6093)ggfs	p.G2031fs	TECTA_ENST00000264037.2_Frame_Shift_Del_p.G2031fs			O75443	TECTA_HUMAN	tectorin alpha	2031	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TAAATTCATAGGGGATTACGA	0.448													22	124	---	---	---	---					
GDF3	9573	broad.mit.edu	37	12	7843285	7843285	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr12:7843285delG	ENST00000329913.3	-	2	331	c.284delC	c.(283-285)cafs	p.P95fs		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	95					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						AATTTTCTTTGGGTAAAGAAA	0.428													14	85	---	---	---	---					
ZMYM2	7750	broad.mit.edu	37	13	20567946	20567946	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:20567946delC	ENST00000382869.3	+	3	985	c.734delC	c.(733-735)acfs	p.T245fs	ZMYM2_ENST00000382874.2_Frame_Shift_Del_p.T245fs|ZMYM2_ENST00000382881.3_Intron|ZMYM2_ENST00000382871.2_Frame_Shift_Del_p.T245fs	NM_001190965.1|NM_003453.3|NM_197968.2	NP_001177894.1|NP_003444.1|NP_932072.1	Q9UBW7	ZMYM2_HUMAN	zinc finger, MYM-type 2	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	ubiquitin conjugating enzyme binding|zinc ion binding			large_intestine(3)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10		all_cancers(29;8.65e-21)|all_epithelial(30;1.04e-18)|all_lung(29;6.75e-18)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;0.000148)|Epithelial(112;0.000249)|OV - Ovarian serous cystadenocarcinoma(117;0.00816)|Lung(94;0.0173)|LUSC - Lung squamous cell carcinoma(192;0.0856)		CAAACATACACCCCATCTTTA	0.393													21	153	---	---	---	---					
WASF3	10810	broad.mit.edu	37	13	27259883	27259883	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr13:27259883delG	ENST00000361042.4	+	10	1626	c.1401delG	c.(1399-1401)gtfs	p.V467fs	WASF3_ENST00000335327.5_Frame_Shift_Del_p.V470fs			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	470					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		GGGAGCCAGTGGGGAATGACG	0.577													8	65	---	---	---	---					
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473028	22473029	+	RNA	INS	-	-	G	rs3814940	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr15:22473028_22473029insG	ENST00000557788.2	-	0	241_242																											TCTTGAGGGACGGGTTGTAGTT	0.564													7	377	---	---	---	---					
TBC1D3P2	440452	broad.mit.edu	37	17	60342474	60342474	+	RNA	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:60342474delG	ENST00000581291.1	-	0	1679																				breast(2)|kidney(1)|lung(2)	5						TAGCTCTGAAGGGGGTGCCCT	0.612													17	100	---	---	---	---					
HELZ	9931	broad.mit.edu	37	17	65163733	65163736	+	Frame_Shift_Del	DEL	AATA	AATA	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr17:65163733_65163736delAATA	ENST00000358691.5	-	14	1773_1776	c.1607_1610delTATT	c.(1606-1611)tafs	p.LL536fs	HELZ_ENST00000580168.1_Frame_Shift_Del_p.LL536fs	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					AGGGACTGGTAATAAATAAACAGC	0.368													16	82	---	---	---	---					
CDH7	1005	broad.mit.edu	37	18	63530030	63530031	+	Frame_Shift_Ins	INS	-	-	GA	rs114470266	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr18:63530030_63530031insGA	ENST00000536984.2	+	11	2435_2436	c.1741_1742insGA	c.(1741-1743)cgtfs	p.R581fs	CDH7_ENST00000397968.2_Frame_Shift_Ins_p.R581fs|CDH7_ENST00000323011.3_Frame_Shift_Ins_p.R581fs			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	581	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CCTCACCATCCGCGTGTGTGAC	0.535													14	71	---	---	---	---					
KEAP1	9817	broad.mit.edu	37	19	10597367	10597367	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:10597367delG	ENST00000171111.5	-	6	2383	c.1836delC	c.(1834-1836)ccfs	p.P612fs	KEAP1_ENST00000393623.2_Frame_Shift_Del_p.P612fs	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GCTTCCGGCAGGGCTCCATGG	0.527													21	152	---	---	---	---					
MEF2B	100271849	broad.mit.edu	37	19	19258547	19258547	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr19:19258547delC	ENST00000602424.2	-	6	1079	c.353delG	c.(352-354)gcfs	p.G118fs	MEF2B_ENST00000424583.2_Frame_Shift_Del_p.G118fs|MEF2B_ENST00000409447.2_Frame_Shift_Del_p.G118fs|MEF2BNB-MEF2B_ENST00000444486.3_Frame_Shift_Del_p.G118fs|MEF2B_ENST00000409224.1_Frame_Shift_Del_p.G121fs|MEF2BNB-MEF2B_ENST00000514819.3_Frame_Shift_Del_p.G135fs|MEF2B_ENST00000162023.5_Frame_Shift_Del_p.G118fs|MEF2B_ENST00000410050.1_Frame_Shift_Del_p.G118fs|MEF2BNB-MEF2B_ENST00000602276.1_5'UTR	NM_005919.3	NP_005910.1			myocyte enhancer factor 2B											breast(1)|haematopoietic_and_lymphoid_tissue(21)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(5;0.00011)|Epithelial(12;0.00412)			ACCCCCTTCGCCTGCCAGCCT	0.627													16	59	---	---	---	---					
TRMT6	51605	broad.mit.edu	37	20	5930980	5930997	+	In_Frame_Del	DEL	GTCGCCGTCGCGGATGCG	GTCGCCGTCGCGGATGCG	-	rs138297718	by1000genomes	TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr20:5930980_5930997delGTCGCCGTCGCGGATGCG	ENST00000203001.2	-	1	185_202	c.55_72delCGCATCCGCGACGGCGAC	c.(55-72)del	p.RIRDGD19del	TRMT6_ENST00000473131.1_5'UTR|TRMT6_ENST00000453074.2_5'UTR	NM_015939.3	NP_057023.2	Q9UJA5	TRM6_HUMAN	tRNA methyltransferase 6 homolog (S. cerevisiae)	19					regulation of translational initiation|tRNA processing	nucleus	protein binding|translation initiation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)	15						GCACCACGAAGTCGCCGTCGCGGATGCGGTGGTCTCCG	0.628													7	111	---	---	---	---					
TPTEP1	387590	broad.mit.edu	37	22	17131536	17131537	+	RNA	INS	-	-	CTG	rs34452519		TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chr22:17131536_17131537insCTG	ENST00000426585.1	+	0	2562_2563																											TGCCCACTCTTCTGGTCTCATG	0.540													4	6	---	---	---	---					
CHM	1121	broad.mit.edu	37	X	85211223	85211223	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-A4SS-01A-11D-A24P-08	TCGA-44-A4SS-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2e0426ee-0178-4925-a895-851f9b7a1b00	1e16ed84-9e7e-4ab6-a83b-a03ab0308fed	g.chrX:85211223delC	ENST00000357749.2	-	8	1130	c.1101delG	c.(1099-1101)cgfs	p.R367fs	CHM_ENST00000537751.1_Frame_Shift_Del_p.R219fs|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	367					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TGTTGCCATACCGCCCAAGAC	0.418													9	40	---	---	---	---