Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MYO5A	4644	broad.mit.edu	37	15	52622589	52622589	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr15:52622589T>A	ENST00000399231.3	-	34	4684	c.4441A>T	c.(4441-4443)Aag>Tag	p.K1481*	MYO5A_ENST00000553916.1_Nonsense_Mutation_p.K1479*|MYO5A_ENST00000399233.2_Nonsense_Mutation_p.K1478*|MYO5A_ENST00000358212.6_Nonsense_Mutation_p.K1506*|MYO5A_ENST00000356338.6_Nonsense_Mutation_p.K1454*	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1481					actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TCATCCTCCTTCTTGTATTCC	0.428000													28	141					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6265487	6265487	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:6265487G>C	ENST00000379936.2	+	6	1691	c.1576G>C	c.(1576-1578)Gct>Cct	p.A526P		NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	526					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTTAAGATTGCTTACCGCAT	0.592000													6	52					0	0	1	0	0
FAF1	11124	broad.mit.edu	37	1	51253830	51253830	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:51253830C>G	ENST00000396153.2	-	4	660	c.209G>C	c.(208-210)aGt>aCt	p.S70T	FAF1_ENST00000371778.4_Missense_Mutation_p.S70T	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	70					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(3)		breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		AGCTGGATGACTTGCTGGATT	0.423000													10	35					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296282	39296282	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:39296282G>T	ENST00000345847.4	-	1	457	c.458C>A	c.(457-459)tCt>tAt	p.S153Y		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	149	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ttcacagcaagaggggcggca	0.662000													4	55					0.150653	0.15248	1	1	0
FRAS1	80144	broad.mit.edu	37	4	79362436	79362436	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:79362436G>T	ENST00000264895.6	+	41	6090	c.5650G>T	c.(5650-5652)Gag>Tag	p.E1884*	FRAS1_ENST00000325942.6_Nonsense_Mutation_p.E1884*	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1883					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TGGCTGCATTGAGAACACAGG	0.453000													6	6					0.00116845	0.001235	1	1	0
FAM122C	159091	broad.mit.edu	37	X	133941655	133941655	+	Silent	SNP	T	T	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chrX:133941655T>G	ENST00000414371.2	+	3	308	c.135T>G	c.(133-135)ggT>ggG	p.G45G	FAM122C_ENST00000370785.3_Silent_p.G9G|FAM122C_ENST00000445123.1_5'UTR|FAM122C_ENST00000475361.1_3'UTR|FAM122C_ENST00000370784.4_Silent_p.G9G	NM_001170780.1|NM_001170784.1	NP_001164251.1|NP_001164255.1	Q6P4D5	F222C_HUMAN	family with sequence similarity 122C	9										endometrium(2)|kidney(1)|lung(2)	5	Acute lymphoblastic leukemia(192;0.000127)					TGAAACTAGGTTTCAAGTCGC	0.522000													18	125					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202912932	202912932	+	Missense_Mutation	SNP	C	C	T	rs145759019		TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:202912932C>T	ENST00000367254.3	-	5	688	c.490G>A	c.(490-492)Gca>Aca	p.A164T	ADIPOR1_ENST00000436244.1_Silent_p.A253A|ADIPOR1_ENST00000340990.5_Silent_p.A253A			Q96A54	ADR1_HUMAN	adiponectin receptor 1	0					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			GGTCCCACTGCGCCACAATGA	0.537000													9	51					0	0	1	0	0
DIS3	22894	broad.mit.edu	37	13	73346337	73346337	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr13:73346337T>G	ENST00000377767.4	-	10	1563	c.1463A>C	c.(1462-1464)gAt>gCt	p.D488A	DIS3_ENST00000545453.1_Missense_Mutation_p.D326A|DIS3_ENST00000377780.4_Missense_Mutation_p.D458A	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	488					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		ATGTAGAGCATCGTCTATATC	0.363000										Multiple Myeloma(4;0.011)			8	32					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120510394	120510394	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:120510394C>T	ENST00000397558.2	+	6	1169	c.1169C>T	c.(1168-1170)tCa>tTa	p.S390L	CCDC64_ENST00000257583.4_Missense_Mutation_p.S39L|CCDC64_ENST00000446727.2_Intron	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	390					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGTGCTGACTCAGCCGTCTCC	0.567000													27	78					0	0	1	0	0
NEDD9	4739	broad.mit.edu	37	6	11190841	11190841	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr6:11190841C>G	ENST00000379446.5	-	5	1427	c.1261G>C	c.(1261-1263)Gag>Cag	p.E421Q	RP3-510L9.1_ENST00000500636.2_RNA|NEDD9_ENST00000504387.1_Missense_Mutation_p.E421Q	NM_001271033.1|NM_006403.3	NP_001257962.1|NP_006394.1	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally down-regulated 9	421					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			ACACCCATCTCAAGGGCCTGC	0.532000													10	54					0	0	1	0	0
SLC25A25	114789	broad.mit.edu	37	9	130868088	130868088	+	Silent	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr9:130868088C>A	ENST00000373066.5	+	7	1229	c.822C>A	c.(820-822)ctC>ctA	p.L274L	SLC25A25_ENST00000373064.5_Silent_p.L242L|SLC25A25_ENST00000373068.2_Silent_p.L276L|SLC25A25_ENST00000373069.5_Silent_p.L288L|SLC25A25_ENST00000432073.2_Silent_p.L262L|SLC25A25_ENST00000433501.1_Silent_p.L139L	NM_001265614.2	NP_001252543.1	Q6KCM7	SCMC2_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25	242					transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)	10						CCAGGTCACTCTGGCGGGGCA	0.577000													15	76					6.31663e-08	6.89462e-08	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29625947	29625947	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr20:29625947T>C	ENST00000278882.3	+	5	571	c.191T>C	c.(190-192)aTt>aCt	p.I64T	FRG1B_ENST00000439954.2_Missense_Mutation_p.I69T|FRG1B_ENST00000358464.4_Missense_Mutation_p.I64T														p.I64T(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCAGATGCAATTGGACCAAGA	0.343000													4	99					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133541671	133541671	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:133541671C>T	ENST00000409261.1	-	14	3086	c.2713G>A	c.(2713-2715)Gac>Aac	p.D905N	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.D905N|NCKAP5_ENST00000405974.3_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	905							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TCTCCACTGTCACTAGACTCA	0.647000													26	53					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195508133	195508133	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:195508133G>A	ENST00000463781.3	-	2	10777	c.10318C>T	c.(10318-10320)Cct>Tct	p.P3440S	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000475231.1_Missense_Mutation_p.P3440S|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	209					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.P3440S(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACAGGAACAGGGGTGGCGTGA	0.592000													3	7					0	0	1	0	0
MCF2	4168	broad.mit.edu	37	X	138729002	138729002	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chrX:138729002C>A	ENST00000520602.1	-	3	371	c.86G>T	c.(85-87)tGt>tTt	p.C29F	MCF2_ENST00000370578.4_Missense_Mutation_p.C114F|MCF2_ENST00000519895.1_Missense_Mutation_p.C29F|MCF2_ENST00000414978.1_Missense_Mutation_p.C29F			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	0	CRAL-TRIO.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					CTCTGGTATACATCTAAAATT	0.313000													5	14					0.0381472	0.0390834	1	1	0
KLHL20	27252	broad.mit.edu	37	1	173720961	173720961	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:173720961C>G	ENST00000209884.4	+	4	792	c.656C>G	c.(655-657)tCc>tGc	p.S219C	KLHL20_ENST00000546011.1_Missense_Mutation_p.S30C	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	219	BACK.				cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						GATATAATATCCAGTGATGAG	0.403000													8	31					0	0	1	0	0
BTG1	694	broad.mit.edu	37	12	92538099	92538099	+	Silent	SNP	A	A	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:92538099A>G	ENST00000256015.3	-	2	634	c.273T>C	c.(271-273)agT>agC	p.S91S		NM_001731.2	NP_001722.1	P62324	BTG1_HUMAN	B-cell translocation gene 1, anti-proliferative	91					cell migration|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of endothelial cell differentiation|positive regulation of myoblast differentiation|regulation of apoptosis|regulation of transcription, DNA-dependent	cytoplasm|nucleus	kinase binding|transcription cofactor activity			haematopoietic_and_lymphoid_tissue(12)|kidney(1)|large_intestine(1)|lung(2)	16		Acute lymphoblastic leukemia(6;3.02e-13)|all_hematologic(6;4.32e-09)				ACAGCTCCTGACTGCTCAGTC	0.507000			T	MYC	BCLL						OREG0022024	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	86					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114268618	114268618	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr7:114268618G>A	ENST00000393500.3	+	9	826	c.6G>A	c.(4-6)atG>atA	p.M2I	FOXP2_ENST00000390668.3_Missense_Mutation_p.M118I|FOXP2_ENST00000350908.4_Missense_Mutation_p.M94I|FOXP2_ENST00000403559.4_Missense_Mutation_p.M94I|FOXP2_ENST00000459666.1_3'UTR|FOXP2_ENST00000393489.3_Missense_Mutation_p.M2I|FOXP2_ENST00000393494.2_Missense_Mutation_p.M94I|FOXP2_ENST00000408937.3_Missense_Mutation_p.M119I|FOXP2_ENST00000378237.3_Missense_Mutation_p.M94I|FOXP2_ENST00000360232.4_Missense_Mutation_p.M94I|FOXP2_ENST00000393498.2_Missense_Mutation_p.M94I|FOXP2_ENST00000393491.3_Missense_Mutation_p.M2I			O15409	FOXP2_HUMAN	forkhead box P2	94					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						TGGCCATGATGACTCCCCAGG	0.468000													10	162					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885744	29885744	+	Silent	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:29885744T>C	ENST00000310624.6	+	4	2148	c.2115T>C	c.(2113-2115)ccT>ccC	p.P705P		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	711	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						CAAAGTCCCCTGAGAAGGCCA	0.562000													5	120					0	0	1	0	0
API5	8539	broad.mit.edu	37	11	43333683	43333683	+	Silent	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:43333683G>C	ENST00000378852.3	+	1	131	c.6G>C	c.(4-6)ccG>ccC	p.P2P	API5_ENST00000420461.2_Silent_p.P2P|API5_ENST00000534600.1_Silent_p.P2P|API5_ENST00000455725.2_5'UTR|API5_ENST00000531273.1_Silent_p.P2P|API5_ENST00000534695.1_Silent_p.P2P	NM_001142930.1|NM_006595.3	NP_001136402.1|NP_006586.1	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5	2		Not acetylated.			anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	20						TCACCATGCCGACAGTAGAGG	0.647000											OREG0020900	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	25					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113510301	113510301	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr13:113510301G>C	ENST00000487903.1	+	20	2408	c.2320G>C	c.(2320-2322)Gac>Cac	p.D774H	ATP11A_ENST00000283558.8_Missense_Mutation_p.D774H|ATP11A_ENST00000375630.2_Missense_Mutation_p.D774H|ATP11A_ENST00000375645.3_Missense_Mutation_p.D774H			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	774					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GCCTCGAGAAGACGGGAGTTC	0.542000													27	100					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578507	7578507	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:7578507G>T	ENST00000420246.2	-	5	555	c.423C>A	c.(421-423)tgC>tgA	p.C141*	TP53_ENST00000445888.2_Nonsense_Mutation_p.C141*|TP53_ENST00000359597.4_Nonsense_Mutation_p.C141*|TP53_ENST00000269305.4_Nonsense_Mutation_p.C141*|TP53_ENST00000455263.2_Nonsense_Mutation_p.C141*|TP53_ENST00000413465.2_Nonsense_Mutation_p.C141*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	141	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		C -> A (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C141W(13)|p.C141*(11)|p.0?(8)|p.A138_P142delAKTCP(4)|p.C141C(4)|p.N131fs*27(2)|p.P142fs*7(1)|p.L137_W146del10(1)|p.C141A(1)|p.C9W(1)|p.A6_P10delAKTCP(1)|p.K139fs*4(1)|p.A45_P49delAKTCP(1)|p.T140fs*28(1)|p.A138_V143delAKTCPV(1)|p.C141fs*5(1)|p.P142del(1)|p.C48W(1)|p.C141_P142insXX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCTGCACAGGGCAGGTCTTGG	0.577000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	39					2.27111e-07	2.46283e-07	1	1	0
PCDH1	5097	broad.mit.edu	37	5	141244682	141244682	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr5:141244682G>C	ENST00000287008.3	-	3	1361	c.1214C>G	c.(1213-1215)tCa>tGa	p.S405*	PCDH1_ENST00000394536.3_Nonsense_Mutation_p.S405*|PCDH1_ENST00000536585.1_Nonsense_Mutation_p.S383*|PCDH1_ENST00000456271.1_Nonsense_Mutation_p.S393*|PCDH1_ENST00000503492.1_Intron|PCDH1_ENST00000511044.1_5'UTR	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	405	Cadherin 4.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CACATCCTCTGAGATGTTAGC	0.557000													6	89					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	37					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67267932	67267932	+	Silent	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:67267932C>T	ENST00000258201.4	-	13	1921	c.1674G>A	c.(1672-1674)ctG>ctA	p.L558L	FHOD1_ENST00000567687.1_Silent_p.L137L	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	558	FH1.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ACTCTACATTCAGCATGTCCT	0.617000													8	67					0	0	1	0	0
DCAF15	90379	broad.mit.edu	37	19	14070103	14070103	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:14070103C>A	ENST00000254337.6	+	7	1052	c.1031C>A	c.(1030-1032)cCt>cAt	p.P344H		NM_138353.2	NP_612362.2	Q66K64	DCA15_HUMAN	DDB1 and CUL4 associated factor 15	344										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)	11						GAAGCCCGGCCTGCCCTGTGC	0.701000													3	25					0.00909568	0.00937641	1	1	0
MCCC1	56922	broad.mit.edu	37	3	182738007	182738007	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:182738007C>G	ENST00000492597.1	-	16	2263	c.1561G>C	c.(1561-1563)Gac>Cac	p.D521H	MCCC1_ENST00000265594.4_Missense_Mutation_p.D630H|MCCC1_ENST00000539926.1_3'UTR			Q96RQ3	MCCA_HUMAN	methylcrotonoyl-CoA carboxylase 1 (alpha)	630					biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(1)|lung(17)|ovary(1)|pancreas(2)|prostate(1)|skin(2)	40	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	ACTGGAATGTCAATCTCAATA	0.378000													6	46					0	0	1	0	0
PHLDA1	22822	broad.mit.edu	37	12	76425191	76425191	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:76425191C>G	ENST00000266671.5	-	1	2521	c.331G>C	c.(331-333)Gag>Cag	p.E111Q	PHLDA1_ENST00000602540.1_5'UTR			Q8WV24	PHLA1_HUMAN	pleckstrin homology-like domain, family A, member 1	111					apoptosis	cytoplasmic vesicle membrane|nucleolus|plasma membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	14		Colorectal(145;0.09)				GCGCCGTCCTCGCCCCAGCGG	0.756000													4	4					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43216966	43216966	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr18:43216966C>A	ENST00000255226.6	+	6	1478	c.662C>A	c.(661-663)tCt>tAt	p.S221Y	SLC14A2_ENST00000586448.1_Missense_Mutation_p.S221Y	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	221						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCAGTTCTTTCTAGTGCCTTG	0.517000													42	155					6.4308e-24	7.35578e-24	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168105622	168105622	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:168105622C>G	ENST00000409195.1	+	9	7809	c.7720C>G	c.(7720-7722)Caa>Gaa	p.Q2574E	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.Q2574E|XIRP2_ENST00000409273.1_Missense_Mutation_p.Q2352E|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2399					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGTTAAAACTCAAAGCCAAAA	0.333000													15	54					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53636079	53636079	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:53636079C>T	ENST00000262135.4	-	25	3710	c.3617G>A	c.(3616-3618)gGt>gAt	p.G1206D	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.G1252D|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.G1286D	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1286					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				AATACCTTCACCATCTGCTCG	0.443000													14	38					0	0	1	0	0
JADE1	79960	broad.mit.edu	37	4	129793167	129793167	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:129793167A>T	ENST00000226319.6	+	11	2559	c.2279A>T	c.(2278-2280)cAg>cTg	p.Q760L	PHF17_ENST00000452328.2_Missense_Mutation_p.Q748L|PHF17_ENST00000512960.1_Missense_Mutation_p.Q760L	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		760					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GGGGAACGGCAGCAGCAGGGA	0.532000													3	24					0	0	1	0	0
SEPT5	5413	broad.mit.edu	37	22	19709227	19709227	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:19709227G>A	ENST00000438754.2	+	8	1089	c.809G>A	c.(808-810)cGg>cAg	p.R270Q	SEPT5_ENST00000455784.2_Missense_Mutation_p.R261Q|SEPT5_ENST00000383045.3_Missense_Mutation_p.R270Q|SEPT5_ENST00000406395.1_Missense_Mutation_p.R261Q	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	261					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					CAGCGGGTCCGGGGCCGACTG	0.677000													27	82					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46298746	46298746	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:46298746C>G	ENST00000334344.6	+	21	5565	c.5393C>G	c.(5392-5394)tCa>tGa	p.S1798*	ARID2_ENST00000444670.1_Nonsense_Mutation_p.S1408*|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000457135.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1798					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		AATAACTTATCAGTGCTAGCC	0.358000			"""N, S, F"""		hepatocellular carcinoma								6	34					0	0	1	0	0
PHLDA1	22822	broad.mit.edu	37	12	76424750	76424750	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:76424750C>G	ENST00000266671.5	-	1	2962	c.772G>C	c.(772-774)Gag>Cag	p.E258Q	RP11-290L1.3_ENST00000552367.1_RNA|PHLDA1_ENST00000602540.1_Missense_Mutation_p.E117Q			Q8WV24	PHLA1_HUMAN	pleckstrin homology-like domain, family A, member 1	258	PH.				apoptosis	cytoplasmic vesicle membrane|nucleolus|plasma membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	14		Colorectal(145;0.09)				TCCTTGCCCTCTGCCATCACC	0.577000													8	33					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000348295.3_Silent_p.S343S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					3	37					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112991470	112991470	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:112991470C>G	ENST00000495514.1	+	7	1585	c.881C>G	c.(880-882)tCa>tGa	p.S294*	BOC_ENST00000355385.3_Nonsense_Mutation_p.S294*|BOC_ENST00000273395.4_Nonsense_Mutation_p.S294*			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	294	Ig-like C2-type 3.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			GAGGAGGACTCAGGCACCTAC	0.617000													15	46					0	0	1	0	0
TTC7B	145567	broad.mit.edu	37	14	91161916	91161916	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr14:91161916C>G	ENST00000357056.2	-	6	826	c.705G>C	c.(703-705)ttG>ttC	p.L235F	TTC7B_ENST00000328459.6_Missense_Mutation_p.L235F			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	235							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				CTCCTCTTGTCAAGTTCCTGT	0.383000													6	34					0	0	1	0	0
LRIG2	9860	broad.mit.edu	37	1	113637318	113637318	+	Silent	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:113637318G>C	ENST00000361127.4	+	6	942	c.744G>C	c.(742-744)cgG>cgC	p.R248R		NM_014813.1	NP_055628.1	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like domains 2	248						cytoplasm|integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(7)|large_intestine(3)|lung(10)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	31	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		AAATGCAGCGGAATGGAATTA	0.358000													15	92					0	0	1	0	0
QTRT1	81890	broad.mit.edu	37	19	10823678	10823678	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:10823678G>A	ENST00000250237.5	+	9	1031	c.1021G>A	c.(1021-1023)Gcg>Acg	p.A341T		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	341					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			CAACACGGCCGCGCTGCACCA	0.682000													7	23					0	0	1	0	0
MCM5	4174	broad.mit.edu	37	22	35817407	35817407	+	Silent	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:35817407C>T	ENST00000216122.4	+	15	2083	c.1929C>T	c.(1927-1929)ctC>ctT	p.L643L	MCM5_ENST00000382011.5_Silent_p.L600L	NM_006739.3	NP_006730.2	P33992	MCM5_HUMAN	minichromosome maintenance complex component 5	643					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	29						CCCTGCGGCTCTTCCAAGTGT	0.612000													46	121					0	0	1	0	0
MLH1	4292	broad.mit.edu	37	3	37081768	37081768	+	Silent	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:37081768C>G	ENST00000231790.2	+	14	1866	c.1650C>G	c.(1648-1650)ctC>ctG	p.L550L	MLH1_ENST00000455445.2_Silent_p.L309L|MLH1_ENST00000435176.1_Silent_p.L452L|MLH1_ENST00000536378.1_Silent_p.L309L|MLH1_ENST00000458205.2_Silent_p.L309L|MLH1_ENST00000539477.1_Silent_p.L309L	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	550	Interaction with EXO1.		L -> P (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TATACCTTCTCAACACCACCA	0.498000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				13	51					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154197823	154197823	+	Silent	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chrX:154197823C>G	ENST00000360256.4	-	7	992	c.792G>C	c.(790-792)ctG>ctC	p.L264L		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	264	F5/8 type A 1.|Plastocyanin-like 2.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GGCATCCAATCAGACCTGTAA	0.418000													27	67					0	0	1	0	0
FBXO41	150726	broad.mit.edu	37	2	73493698	73493698	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:73493698C>T	ENST00000521871.1	-	3	1433	c.1018G>A	c.(1018-1020)Gag>Aag	p.E340K	FBXO41_ENST00000295133.5_Missense_Mutation_p.E401K|FBXO41_ENST00000520530.2_Missense_Mutation_p.E340K			Q8TF61	FBX41_HUMAN	F-box protein 41	340						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						AGCTGCCGCTCGGCACGGTCA	0.701000													4	26					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			19	16					7.88262e-20	8.89458e-20	1	1	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240729	39240729	+	Missense_Mutation	SNP	A	A	G	rs148949542	by1000genomes	TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:39240729A>G	ENST00000391417.4	+	1	271	c.271A>G	c.(271-273)Atg>Gtg	p.M91V		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						cagctgctgtatgtccagctg	0.677000													3	65					0	0	1	0	0
KRTAP4-4	84616	broad.mit.edu	37	17	39316759	39316759	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:39316759T>C	ENST00000390661.3	-	1	224	c.185A>G	c.(184-186)cAc>cGc	p.H62R		NM_032524.1	NP_115913.1	Q9BYR3	KRA44_HUMAN	keratin associated protein 4-4	62	26 X 5 AA repeats of C-C-[GRQVCH]-[SPT]- [VSTQR].		Missing (in allele KAP4.13).|Missing (in allele KAP4.4-v1).			keratin filament				kidney(1)|large_intestine(1)|lung(5)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GCAGCTGGGGTGGCAGCAGGT	0.662000													4	112					0	0	1	0	0
CRAMP1L	57585	broad.mit.edu	37	16	1705274	1705274	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:1705274G>C	ENST00000397412.3	+	9	1191	c.1092G>C	c.(1090-1092)caG>caC	p.Q364H	CRAMP1L_ENST00000436138.3_Missense_Mutation_p.Q361H|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.Q364H|LA16c-431H6.6_ENST00000454337.1_3'UTR			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	364						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						TCTTGAAGCAGAAGTGGGCGC	0.552000													32	32					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657465	1657465	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:1657465G>C	ENST00000324015.3	+	10	1190	c.1113G>C	c.(1111-1113)caG>caC	p.Q371H	SERPINF2_ENST00000450523.2_Missense_Mutation_p.Q307H|SERPINF2_ENST00000382061.4_Missense_Mutation_p.Q371H	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	371					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TCTCCGAGCAGAGCCTGGTGG	0.677000													11	76					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3179079	3179079	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:3179079G>T	ENST00000355072.5	+	34	4573	c.4428G>T	c.(4426-4428)ttG>ttT	p.L1476F		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1476					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GCTTTGTATTGAAACAGTTTG	0.299000													8	18					3.86212e-05	4.16112e-05	1	1	0
RHOBTB3	22836	broad.mit.edu	37	5	95099311	95099311	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr5:95099311A>G	ENST00000379982.3	+	7	1656	c.1148A>G	c.(1147-1149)aAa>aGa	p.K383R	GLRX_ENST00000508780.1_Intron	NM_014899.3	NP_055714.3	O94955	RHBT3_HUMAN	Rho-related BTB domain containing 3	383					retrograde transport, endosome to Golgi	Golgi apparatus	ATP binding|ATPase activity|Rab GTPase binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|skin(1)	16		all_cancers(142;2.58e-06)|all_epithelial(76;4.19e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.79e-16)		TGCATTTTAAAAACACCAGGA	0.328000													8	38					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62169209	62169209	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr15:62169209T>G	ENST00000261517.5	-	75	10260	c.10187A>C	c.(10186-10188)cAg>cCg	p.Q3396P	VPS13C_ENST00000395896.4_Missense_Mutation_p.Q3396P|VPS13C_ENST00000395898.3_Missense_Mutation_p.Q3353P|VPS13C_ENST00000558919.1_5'UTR|VPS13C_ENST00000249837.3_Missense_Mutation_p.Q3353P	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	3396					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						CCATATAAGCTGATCTCTCTT	0.294000													10	97					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60907449	60907449	+	Silent	SNP	G	G	A	rs142357165		TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr20:60907449G>A	ENST00000252999.3	-	28	3597	c.3531C>T	c.(3529-3531)gcC>gcT	p.A1177A		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1177	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGCCTGTTCGGCTGTGAGCC	0.627000													9	109					0	0	1	0	0
ARAP2	116984	broad.mit.edu	37	4	36189162	36189162	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:36189162G>C	ENST00000303965.4	-	8	2078	c.1589C>G	c.(1588-1590)tCt>tGt	p.S530C		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	530	PH 1.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TGATATAGCAGAAAGGGGAAT	0.308000													16	34					0	0	1	0	0
NTNG2	84628	broad.mit.edu	37	9	135073778	135073778	+	Silent	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr9:135073778C>T	ENST00000393229.3	+	3	1415	c.639C>T	c.(637-639)ttC>ttT	p.F213F	NTNG2_ENST00000360670.3_Silent_p.F213F|NTNG2_ENST00000393228.4_Silent_p.F213F|NTNG2_ENST00000372179.3_Silent_p.F213F	NM_032536.2	NP_115925.2	Q96CW9	NTNG2_HUMAN	netrin G2	213	Laminin N-terminal.				axonogenesis	anchored to plasma membrane				central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	29				OV - Ovarian serous cystadenocarcinoma(145;1.23e-05)|Epithelial(140;0.000173)		ACGTGCGCTTCGAGGTGCGGG	0.667000													9	37					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167023506	167023506	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:167023506G>C	ENST00000392766.2	-	17	1990	c.1650C>G	c.(1648-1650)atC>atG	p.I550M	ZBBX_ENST00000455345.2_Missense_Mutation_p.I550M|ZBBX_ENST00000392764.1_Missense_Mutation_p.I521M|ZBBX_ENST00000307529.5_Missense_Mutation_p.I550M|ZBBX_ENST00000392767.2_Missense_Mutation_p.I550M	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	550						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AGGATTCTTTGATGTCTTGAG	0.343000													16	31					0	0	1	0	0
MRPL4	51073	broad.mit.edu	37	19	10369342	10369342	+	Silent	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:10369342C>T	ENST00000393733.2	+	8	747	c.720C>T	c.(718-720)ttC>ttT	p.F240F	CTD-2369P2.5_ENST00000592893.1_RNA|MRPL4_ENST00000307422.5_Silent_p.F240F|MRPL4_ENST00000590669.1_Silent_p.F240F|MRPL4_ENST00000253099.6_Silent_p.F240F			Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4	240					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	11		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		TTAAGACCTTCAACTTGATCC	0.567000													10	82					0	0	1	0	0
ART3	419	broad.mit.edu	37	4	76997033	76997033	+	Splice_Site	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:76997033G>C	ENST00000355810.4	+	2	110		c.e2-1		ART3_ENST00000513494.1_Splice_Site|ART3_ENST00000341029.5_Splice_Site|ART3_ENST00000349321.3_Splice_Site	NM_001130016.2	NP_001123488.1	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3						protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|stomach(1)	16			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTTTAATTTAGAAGAGAAAAA	0.358000													4	55					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186120395	186120395	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:186120395C>T	ENST00000271588.4	+	94	14901	c.14672C>T	c.(14671-14673)gCt>gTt	p.A4891V	HMCN1_ENST00000367492.2_Missense_Mutation_p.A4891V	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4891	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TTTGGAATTGCTTTCCTTAAT	0.398000													16	81					0	0	1	0	0
DNAJC21	134218	broad.mit.edu	37	5	34954703	34954703	+	Missense_Mutation	SNP	C	C	T	rs141076061		TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr5:34954703C>T	ENST00000382021.2	+	13	1842	c.1615C>T	c.(1615-1617)Cgg>Tgg	p.R539W	DNAJC21_ENST00000303525.7_Missense_Mutation_p.R507W|DNAJC21_ENST00000342382.4_Missense_Mutation_p.R494W	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	494					protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			ATTTCCATCTCGGAATAAACT	0.388000													11	132					0	0	1	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1853768	1853768	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr8:1853768G>T	ENST00000518288.1	+	18	2088	c.1925G>T	c.(1924-1926)cGa>cTa	p.R642L	ARHGEF10_ENST00000520359.1_Missense_Mutation_p.R580L|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.R643L|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.R643L|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.R618L			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	643					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TACCTCATTCGATCAGATGAT	0.428000													4	92					1	1	1	1	0
TARBP1	6894	broad.mit.edu	37	1	234566017	234566017	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:234566017C>G	ENST00000040877.1	-	15	2424	c.2425G>C	c.(2425-2427)Gta>Cta	p.V809L		NM_005646.3	NP_005637.3	Q13395	TARB1_HUMAN	TAR (HIV-1) RNA binding protein 1	809					regulation of transcription from RNA polymerase II promoter|RNA processing	nucleus	RNA binding|RNA methyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(7)|large_intestine(6)|lung(22)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	55	Ovarian(103;0.0339)	all_cancers(173;0.00995)|Prostate(94;0.0115)|all_epithelial(177;0.172)	OV - Ovarian serous cystadenocarcinoma(106;0.000263)			ATGCTCACTACTCTCTGAATC	0.483000													9	44					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30490717	30490717	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:30490717G>A	ENST00000356798.6	+	6	691	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000454514.2_Intron|ITGAL_ENST00000358164.5_Intron|RP11-297C4.2_ENST00000569459.1_RNA	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	171	VWFA.				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GCAGCCAGATGAATTTCAGAA	0.438000													5	41					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124402690	124402690	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr10:124402690G>T	ENST00000368909.3	+	53	7124	c.7018G>T	c.(7018-7020)Gcc>Tcc	p.A2340S	DMBT1_ENST00000368956.2_Missense_Mutation_p.A1712S|DMBT1_ENST00000359586.6_Missense_Mutation_p.A1060S|DMBT1_ENST00000330163.4_Missense_Mutation_p.A1712S|DMBT1_ENST00000338354.3_Missense_Mutation_p.A2340S|DMBT1_ENST00000344338.3_Missense_Mutation_p.A2330S|DMBT1_ENST00000368955.3_Missense_Mutation_p.A2330S	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2340	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TCTTCGCATTGCCCGCTTCCG	0.577000													21	71					1.96292e-10	2.18539e-10	1	1	0
NUP98	4928	broad.mit.edu	37	11	3800193	3800193	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:3800193T>C	ENST00000324932.7	-	4	685	c.265A>G	c.(265-267)Aat>Gat	p.N89D	NUP98_ENST00000355260.3_Missense_Mutation_p.N89D|NUP98_ENST00000397007.4_Missense_Mutation_p.N89D|NUP98_ENST00000397004.4_Missense_Mutation_p.N89D|NUP98_ENST00000359171.4_Missense_Mutation_p.N89D	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	89	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AACAAGGTATTTGCTGTTCCT	0.478000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								6	70					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39103253	39103253	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:39103253G>A	ENST00000591517.1	-	9	691	c.663C>T	c.(661-663)ctC>ctT	p.L221L	MAP4K1_ENST00000396857.2_Silent_p.L221L|MAP4K1_ENST00000586296.1_Silent_p.L221L|MAP4K1_ENST00000589130.1_Silent_p.L217L|MAP4K1_ENST00000589002.1_5'UTR|MAP4K1_ENST00000423454.2_5'UTR	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	221	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTGCCTACCTGAGAGGGTGCA	0.607000													13	29					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10030698	10030698	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr20:10030698C>G	ENST00000378380.3	+	6	1810	c.1481C>G	c.(1480-1482)tCa>tGa	p.S494*	SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000378392.1_Nonsense_Mutation_p.S494*	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		AAGGTATTTTCAAACATTAAT	0.383000													10	100					0	0	1	0	0
MTSS1	9788	broad.mit.edu	37	8	125577908	125577908	+	Silent	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr8:125577908G>C	ENST00000518547.1	-	9	1292	c.819C>G	c.(817-819)gtC>gtG	p.V273V	MTSS1_ENST00000395508.2_Silent_p.V7V|MTSS1_ENST00000524090.1_Silent_p.V163V|MTSS1_ENST00000378017.3_Silent_p.V273V|MTSS1_ENST00000325064.5_Silent_p.V277V|NDUFB9_ENST00000522532.1_Intron|MTSS1_ENST00000354184.4_Silent_p.V73V|MTSS1_ENST00000431961.2_Silent_p.V73V	NM_014751.4	NP_055566.3	O43312	MTSS1_HUMAN	metastasis suppressor 1	273	Ser-rich.				actin cytoskeleton organization|cell adhesion|cellular component movement|filopodium assembly|transmembrane receptor protein tyrosine kinase signaling pathway	actin cytoskeleton|endocytic vesicle|ruffle	actin monomer binding|cytoskeletal adaptor activity|receptor binding|SH3 domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37	Ovarian(258;0.00438)|all_neural(195;0.00459)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTCACCTGCAGACACTGGACT	0.507000													13	39					0	0	1	0	0
USP34	9736	broad.mit.edu	37	2	61484020	61484020	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:61484020C>T	ENST00000398571.2	-	47	6190	c.6114G>A	c.(6112-6114)atG>atA	p.M2038I		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	2038					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			AAATGTTCTTCATATCAGCCA	0.299000													5	48					0	0	1	0	0
BCL7C	9274	broad.mit.edu	37	16	30905233	30905233	+	Silent	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:30905233C>T	ENST00000380317.4	-	1	390	c.33G>A	c.(31-33)cgG>cgA	p.R11R	BCL7C_ENST00000215115.4_Silent_p.R11R|MIR4519_ENST00000570025.1_RNA|AC106782.20_ENST00000572471.1_RNA|MIR4519_ENST00000564901.1_RNA|MIR762_ENST00000390236.1_RNA|MIR4519_ENST00000565573.1_RNA			Q8WUZ0	BCL7C_HUMAN	B-cell CLL/lymphoma 7C	11					apoptosis					large_intestine(1)|lung(3)|prostate(1)|skin(1)	6			Colorectal(24;0.198)			TGGCCCGGCTCCGGGTCTCGG	0.746000													5	57					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120613633	120613633	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:120613633G>C	ENST00000300648.6	-	11	970	c.958C>G	c.(958-960)Ctg>Gtg	p.L320V		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	320					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CGCAGTGCCAGCACAGCTTCA	0.552000													7	30					0	0	1	0	0
MAD1L1	8379	broad.mit.edu	37	7	1997277	1997277	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr7:1997277C>T	ENST00000406869.1	-	16	2140	c.1583G>A	c.(1582-1584)cGg>cAg	p.R528Q	MAD1L1_ENST00000402746.1_Missense_Mutation_p.R436Q|MAD1L1_ENST00000265854.7_Missense_Mutation_p.R528Q|MAD1L1_ENST00000399654.2_Missense_Mutation_p.R528Q			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	528	Necessary for interaction with NEK2.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		CAGAGCTCGCCGCTCCAGCTG	0.637000													14	96					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18142502	18142502	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr20:18142502G>C	ENST00000278816.2	+	6	1371	c.721G>C	c.(721-723)Gag>Cag	p.E241Q	CSRP2BP_ENST00000435364.2_Missense_Mutation_p.E241Q|CSRP2BP_ENST00000377681.2_Missense_Mutation_p.E240Q|CSRP2BP_ENST00000489634.2_Missense_Mutation_p.E113Q			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	241					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						CATTACTGTTGAGGGACTTAG	0.418000													20	85					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32635535	32635535	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:32635535G>C	ENST00000335185.5	-	16	2372	c.2329C>G	c.(2329-2331)Ctt>Gtt	p.L777V		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	777										NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TTAAGATGAAGATGGGAAATG	0.328000													9	38					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43846118	43846118	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:43846118C>T	ENST00000389420.3	-	14	2037	c.2038G>A	c.(2038-2040)Gga>Aga	p.G680R	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G680R	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	680	Cys-rich.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTTTCAGTTCCACAAGGAGTA	0.343000													24	37					0	0	1	0	0
NUP188	23511	broad.mit.edu	37	9	131721149	131721149	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr9:131721149C>G	ENST00000372577.2	+	7	462	c.441C>G	c.(439-441)ttC>ttG	p.F147L		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	147					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						TCACTTACTTCCAAGATGAAA	0.313000													3	28					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50769116	50769116	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr15:50769116G>T	ENST00000433963.1	+	10	1420	c.920G>T	c.(919-921)tGt>tTt	p.C307F	USP8_ENST00000425032.3_Missense_Mutation_p.C230F|USP8_ENST00000396444.3_Missense_Mutation_p.C307F|USP8_ENST00000307179.4_Missense_Mutation_p.C307F	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	307	Rhodanese.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TGGCTCCTTTGTTATCCCCAG	0.388000													16	63					1.33834e-09	1.48015e-09	1	1	0
MYH13	8735	broad.mit.edu	37	17	10248849	10248849	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:10248849C>A	ENST00000418404.3	-	13	1511	c.1348G>T	c.(1348-1350)Gac>Tac	p.D450Y	MYH13_ENST00000570743.1_Missense_Mutation_p.D450Y|MYH13_ENST00000252172.4_Missense_Mutation_p.D450Y			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	450	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TGCTTGGTGTCCAGCTGCTGG	0.512000													45	93					5.39261e-20	6.1263e-20	1	1	0
MTMR1	8776	broad.mit.edu	37	X	149901147	149901147	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chrX:149901147C>A	ENST00000445323.2	+	10	1146	c.1025C>A	c.(1024-1026)tCa>tAa	p.S342*	MTMR1_ENST00000538506.1_Nonsense_Mutation_p.S221*|MTMR1_ENST00000544228.1_Nonsense_Mutation_p.S334*|MTMR1_ENST00000542156.1_Nonsense_Mutation_p.S334*|MTMR1_ENST00000451863.2_Nonsense_Mutation_p.S334*|MTMR1_ENST00000370390.3_Nonsense_Mutation_p.S334*|MTMR1_ENST00000541925.1_Nonsense_Mutation_p.S240*			Q13613	MTMR1_HUMAN	myotubularin related protein 1	334	Myotubularin phosphatase.					plasma membrane	protein tyrosine phosphatase activity	p.S334*(1)		central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AACGCACAGTCACACAAGCTT	0.423000													9	54					4.68919e-08	5.15194e-08	1	1	0
SHPRH	257218	broad.mit.edu	37	6	146276084	146276084	+	Silent	SNP	A	A	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr6:146276084A>T	ENST00000367503.3	-	2	773	c.375T>A	c.(373-375)ccT>ccA	p.P125P	SHPRH_ENST00000275233.7_Silent_p.P125P|SHPRH_ENST00000438092.2_Silent_p.P125P|SHPRH_ENST00000367505.2_Silent_p.P125P	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	125					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AACTCTGTGCAGGAAGAAGCT	0.338000													11	24					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128870740	128870740	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:128870740A>T	ENST00000375990.3	+	6	935	c.532A>T	c.(532-534)Att>Ttt	p.I178F	UGGT1_ENST00000259253.6_Missense_Mutation_p.I202F			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	202					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CTACTCTGAGATTGGCTCTGA	0.343000													27	63					0	0	1	0	0
STRADA	92335	broad.mit.edu	37	17	61781922	61781922	+	Silent	SNP	G	G	A	rs147552949		TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:61781922G>A	ENST00000392950.4	-	9	1041	c.768C>T	c.(766-768)aaC>aaT	p.N256N	STRADA_ENST00000582137.1_Silent_p.N264N|STRADA_ENST00000447001.3_Silent_p.N249N|STRADA_ENST00000245865.5_3'UTR|STRADA_ENST00000336174.6_Silent_p.N293N|RP11-51F16.8_ENST00000580553.1_3'UTR|STRADA_ENST00000580039.1_5'UTR|STRADA_ENST00000375840.4_Silent_p.N235N|STRADA_ENST00000579340.1_3'UTR	NM_001003786.2|NM_001165969.1|NM_153335.5	NP_001003786.1|NP_001159441.1|NP_699166.2	Q7RTN6	STRAA_HUMAN	STE20-related kinase adaptor alpha	293	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|kinase binding|protein kinase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(2)|ovary(1)|prostate(2)	13						GCACTGTGCCGTTCAGTTTCT	0.632000													21	74					0	0	1	0	0
HDLBP	3069	broad.mit.edu	37	2	242187753	242187753	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:242187753C>A	ENST00000391975.1	-	13	1750	c.1523G>T	c.(1522-1524)cGt>cTt	p.R508L	HDLBP_ENST00000476807.1_5'UTR|HDLBP_ENST00000391976.2_Missense_Mutation_p.R508L|HDLBP_ENST00000310931.4_Missense_Mutation_p.R508L|HDLBP_ENST00000427183.2_Missense_Mutation_p.R475L	NM_203346.3	NP_976221.1	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	508	KH 5.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding	p.R508H(1)		breast(7)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		ATCCTTGGTACGCTCATTTTC	0.458000													24	72					2.44723e-14	2.74287e-14	1	1	0
MAATS1	89876	broad.mit.edu	37	3	119434438	119434438	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:119434438C>T	ENST00000273390.5	+	6	607	c.530C>T	c.(529-531)tCt>tTt	p.S177F	MAATS1_ENST00000463700.1_Missense_Mutation_p.S177F	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		CCTCCTACTTCTACTAAGCAC	0.368000													37	175					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30732535	30732535	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:30732535G>A	ENST00000262518.4	+	21	3664	c.3279G>A	c.(3277-3279)ctG>ctA	p.L1093L	SRCAP_ENST00000395059.2_Silent_p.L1093L|SRCAP_ENST00000344771.4_Intron	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1093	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TGGGGGTCCTGAGTGGGACCT	0.602000													21	107					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741340	242741340	+	Silent	SNP	A	A	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:242741340A>G	ENST00000192314.6	+	3	395	c.264A>G	c.(262-264)tcA>tcG	p.S88S		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	88					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CCGCCGGCTCACGCGTCCACC	0.642000													7	78					0	0	1	0	0
ZC3H14	79882	broad.mit.edu	37	14	89077222	89077222	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr14:89077222C>G	ENST00000251038.5	+	16	2367	c.2142C>G	c.(2140-2142)ttC>ttG	p.F714L	ZC3H14_ENST00000557607.1_Missense_Mutation_p.F398L|ZC3H14_ENST00000556945.1_Missense_Mutation_p.F583L|ZC3H14_ENST00000406216.3_Missense_Mutation_p.F260L|ZC3H14_ENST00000393514.5_Missense_Mutation_p.F689L|ZC3H14_ENST00000359301.3_Missense_Mutation_p.F549L|ZC3H14_ENST00000336693.4_Missense_Mutation_p.F549L|ZC3H14_ENST00000318308.6_Missense_Mutation_p.F284L|ZC3H14_ENST00000302216.8_Missense_Mutation_p.F557L|ZC3H14_ENST00000555900.1_Missense_Mutation_p.F416L|ZC3H14_ENST00000555755.1_Missense_Mutation_p.F708L	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	714						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						ACTGCACATTCTACCATCCCA	0.393000													20	84					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652803	121652803	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr7:121652803A>G	ENST00000393386.2	+	12	4114	c.3703A>G	c.(3703-3705)Atg>Gtg	p.M1235V	PTPRZ1_ENST00000483028.1_Intron|PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1235					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.M1235V(2)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AAGTGAAAACATGCTGCACTC	0.393000													9	130					0	0	1	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58023955	58023955	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:58023955T>A	ENST00000341156.4	-	6	1276	c.692A>T	c.(691-693)cAg>cTg	p.Q231L	B4GALNT1_ENST00000550764.1_Missense_Mutation_p.Q231L|B4GALNT1_ENST00000449184.3_Missense_Mutation_p.Q231L|B4GALNT1_ENST00000552350.1_Missense_Mutation_p.Q231L|B4GALNT1_ENST00000418555.2_Missense_Mutation_p.Q176L	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	231					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TGTGTTGGTCTGGTAGCTTCG	0.577000													7	86					0	0	1	0	0
ROCK1	6093	broad.mit.edu	37	18	18586533	18586533	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr18:18586533C>G	ENST00000399799.1	-	16	2604	c.1664G>C	c.(1663-1665)aGg>aCg	p.R555T		NM_005406.2	NP_005397.1	Q13464	ROCK1_HUMAN	Rho-associated, coiled-coil containing protein kinase 1	555	Interaction with FHOD1.				actin cytoskeleton organization|axon guidance|cellular component disassembly involved in apoptosis|cytokinesis|leukocyte tethering or rolling|membrane to membrane docking|Rho protein signal transduction	centriole|cytosol|Golgi membrane	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|large_intestine(8)|lung(2)	16	Melanoma(1;0.165)					CGATTCTGTCCTAAGTAAGTC	0.348000													12	45					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38154137	38154137	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:38154137G>C	ENST00000406386.3	+	16	6460	c.6205G>C	c.(6205-6207)Gag>Cag	p.E2069Q	TRIOBP_ENST00000403663.2_Missense_Mutation_p.E356Q|RP1-37E16.12_ENST00000455236.1_RNA|TRIOBP_ENST00000407319.2_Missense_Mutation_p.E356Q	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2069					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CGAGGCACTGGAGAAGGAGGT	0.662000													7	26					0	0	1	0	0
NR2E1	7101	broad.mit.edu	37	6	108499435	108499435	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr6:108499435T>C	ENST00000368986.4	+	5	1340	c.632T>C	c.(631-633)tTg>tCg	p.L211S	NR2E1_ENST00000368983.3_Missense_Mutation_p.L248S	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	211	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		ACGCTGTCTTTGCAAGACCAG	0.507000													8	54					0	0	1	0	0
SLC4A11	83959	broad.mit.edu	37	20	3211402	3211402	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr20:3211402C>T	ENST00000380059.3	-	11	1488	c.1387G>A	c.(1387-1389)Gcg>Acg	p.A463T	SLC4A11_ENST00000539553.1_Missense_Mutation_p.A420T|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000380056.3_Missense_Mutation_p.A436T	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	436	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						GCCAGGGGCGCGGTGGTCAGC	0.682000													3	38					0	0	1	0	0
GORASP1	64689	broad.mit.edu	37	3	39139759	39139759	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:39139759C>T	ENST00000319283.3	-	9	2112	c.1291G>A	c.(1291-1293)Gac>Aac	p.D431N	GORASP1_ENST00000479927.1_Missense_Mutation_p.D336N|GORASP1_ENST00000422110.2_Missense_Mutation_p.D276N	NM_031899.2	NP_114105.1	Q9BQQ3	GORS1_HUMAN	golgi reassembly stacking protein 1, 65kDa	431					mitotic prophase|protein transport	cytosol|Golgi apparatus|membrane				central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(1)|ovary(3)|urinary_tract(1)	14				KIRC - Kidney renal clear cell carcinoma(284;0.0519)|Kidney(284;0.0653)		GCCTGGCTGTCCAGCCCCTCA	0.607000													20	47					0	0	1	0	0
POLR2K	5440	broad.mit.edu	37	8	101163574	101163574	+	Splice_Site	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr8:101163574G>A	ENST00000353107.3	+	2	126		c.e2-1		POLR2K_ENST00000522439.1_Splice_Site|POLR2K_ENST00000519765.1_3'UTR	NM_005034.3	NP_005025.1	P53803	RPAB4_HUMAN	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa						mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.59e-09)|all cancers(13;1.74e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TGTGATTTCAGGGGCTAACAA	0.418000													11	69					0	0	1	0	0
FAM89B	23625	broad.mit.edu	37	11	65341071	65341071	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:65341071C>T	ENST00000316409.2	+	2	811	c.490C>T	c.(490-492)Cgt>Tgt	p.R164C	FAM89B_ENST00000449319.2_3'UTR|FAM89B_ENST00000530349.1_Missense_Mutation_p.R177C	NM_001098784.1|NM_001098785.1|NM_152832.2	NP_001092254.1|NP_001092255.1|NP_690045.1	Q8N5H3	FA89B_HUMAN	family with sequence similarity 89, member B	164										large_intestine(1)|urinary_tract(2)	3						GCACAATGCCCGTGACCAGTG	0.662000													11	43					0	0	1	0	0
TRAV26-1	28657	broad.mit.edu	37	14	22592028	22592028	+	RNA	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr14:22592028C>G	ENST00000390455.3	+	0	322																											GCAAACCTGCCTTGTAATCAC	0.443000													7	118					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3789613	3789613	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:3789613C>G	ENST00000262367.5	-	25	5055	c.4246G>C	c.(4246-4248)Gaa>Caa	p.E1416Q	CREBBP_ENST00000382070.3_Missense_Mutation_p.E1378Q	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1416	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GAGCCGTATTCTTGGACGTGC	0.493000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						11	42					0	0	1	0	0
SMG5	23381	broad.mit.edu	37	1	156235927	156235927	+	Silent	SNP	A	A	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:156235927A>G	ENST00000361813.5	-	12	1644	c.1500T>C	c.(1498-1500)agT>agC	p.S500S	SMG5_ENST00000368267.4_Intron	NM_015327.2	NP_056142.2	Q9UPR3	SMG5_HUMAN	SMG5 nonsense mediated mRNA decay factor	500					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|nucleus	protein phosphatase 2A binding			NS(1)|breast(3)|endometrium(8)|kidney(2)|large_intestine(7)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	48	Hepatocellular(266;0.158)					CACCTTCAAGACTCTTGTCAG	0.532000													16	98					0	0	1	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671975	39671975	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr21:39671975G>A	ENST00000398930.1	+	4	1146	c.792G>A	c.(790-792)ctG>ctA	p.L264L	KCNJ15_ENST00000398934.1_Silent_p.L264L|KCNJ15_ENST00000328656.3_Silent_p.L264L|KCNJ15_ENST00000398938.2_Silent_p.L264L|KCNJ15_ENST00000398932.1_Silent_p.L264L			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	264					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						CGAGCCCCCTGAGAGACCTCA	0.547000													12	30					0	0	1	0	0
TDGF1P3	6998	broad.mit.edu	37	X	109764337	109764337	+	RNA	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chrX:109764337T>C	ENST00000602699.1	+	0	798					NR_002718.2																						ACGCCTCTTTTCCCCCTAATT	0.403000													25	57					0	0	1	0	0
MSI2	124540	broad.mit.edu	37	17	55478817	55478817	+	Silent	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:55478817C>T	ENST00000284073.2	+	6	599	c.390C>T	c.(388-390)ttC>ttT	p.F130F	MSI2_ENST00000442934.2_Silent_p.F69F|MSI2_ENST00000322684.3_Silent_p.F126F|MSI2_ENST00000579180.1_Silent_p.F26F|MSI2_ENST00000416426.2_Silent_p.F108F	NM_138962.2	NP_620412.1	Q96DH6	MSI2H_HUMAN	musashi RNA-binding protein 2	130	RRM 2.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(1)|pancreas(1)|skin(1)	7	Breast(9;1.78e-08)			GBM - Glioblastoma multiforme(1;0.0025)		AGCAATATTTCGAGCAGTTTG	0.488000			T	HOXA9	CML								20	61					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37431192	37431192	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr10:37431192A>T	ENST00000374660.1	+	7	1298	c.1199A>T	c.(1198-1200)gAa>gTa	p.E400V	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E400V|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E400V			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	456						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CCTACAAAAGAATCATCTACA	0.378000													4	20					0	0	1	0	0
TIMP3	7078	broad.mit.edu	37	22	33255201	33255201	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:33255201C>T	ENST00000266085.6	+	5	774	c.473C>T	c.(472-474)aCt>aTt	p.T158I	SYN3_ENST00000332840.5_Intron|SYN3_ENST00000358763.2_Intron	NM_000362.4	NP_000353.1	P35625	TIMP3_HUMAN	TIMP metallopeptidase inhibitor 3	158	Mediates interaction with EFEMP1.				negative regulation of membrane protein ectodomain proteolysis|visual perception		metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(2)|large_intestine(3)|lung(1)|urinary_tract(1)	7						TGCTTTGTGACTTCCAAGAAC	0.542000													72	61					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120475322	120475322	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr9:120475322T>G	ENST00000355622.6	+	3	1017	c.916T>G	c.(916-918)Tgt>Ggt	p.C306G	TLR4_ENST00000394487.4_Missense_Mutation_p.C266G|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	306			C -> W (in dbSNP:rs2770145).		activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CTTATTTAATTGTTTGACAAA	0.338000													12	55					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204944417	204944417	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:204944417G>A	ENST00000367172.4	+	15	1905	c.1577G>A	c.(1576-1578)cGg>cAg	p.R526Q	NFASC_ENST00000338586.6_Missense_Mutation_p.R526Q|NFASC_ENST00000404907.1_Missense_Mutation_p.R537Q|NFASC_ENST00000401399.1_Missense_Mutation_p.R526Q|NFASC_ENST00000367170.4_Missense_Mutation_p.R526Q|NFASC_ENST00000360049.4_Missense_Mutation_p.R537Q|NFASC_ENST00000403080.1_Missense_Mutation_p.R526Q|NFASC_ENST00000339876.6_Missense_Mutation_p.R526Q|NFASC_ENST00000539706.1_Missense_Mutation_p.R537Q|NFASC_ENST00000404076.1_Missense_Mutation_p.R520Q|NFASC_ENST00000513543.1_Missense_Mutation_p.R537Q|NFASC_ENST00000367171.4_Missense_Mutation_p.R526Q|NFASC_ENST00000367169.4_Missense_Mutation_p.R526Q|NFASC_ENST00000338515.6_Missense_Mutation_p.R526Q			O94856	NFASC_HUMAN	neurofascin	526	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGGATCTACCGGATGCCCGAG	0.632000											OREG0014142	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	75					0	0	1	0	0
ADAM22	53616	broad.mit.edu	37	7	87778374	87778374	+	Splice_Site	SNP	T	T	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr7:87778374T>A	ENST00000398204.4	+	18	1889		c.e18+2		ADAM22_ENST00000315984.7_Splice_Site|ADAM22_ENST00000265727.7_Splice_Site|ADAM22_ENST00000398201.4_Splice_Site|ADAM22_ENST00000398209.3_Splice_Site	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22						cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TCAAGCCAGGTAATTTACAAA	0.388000													3	28					0	0	1	0	0
PHLDA1	22822	broad.mit.edu	37	12	76424317	76424317	+	Nonstop_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:76424317C>G	ENST00000266671.5	-	1	3395	c.1205G>C	c.(1204-1206)tGa>tCa	p.*402S	RP11-290L1.3_ENST00000552367.1_RNA|PHLDA1_ENST00000602540.1_Nonstop_Mutation_p.*261S			Q8WV24	PHLA1_HUMAN	pleckstrin homology-like domain, family A, member 1	0					apoptosis	cytoplasmic vesicle membrane|nucleolus|plasma membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	14		Colorectal(145;0.09)				CTGCCCCTTTCAGGCAGAGTT	0.662000													9	61					0	0	1	0	0
ARL2	402	broad.mit.edu	37	11	64787927	64787927	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:64787927A>G	ENST00000246747.4	+	4	471	c.376A>G	c.(376-378)Aag>Gag	p.K126E	ARL2_ENST00000533729.1_Intron|ARL2_ENST00000529384.1_Missense_Mutation_p.K126E|SNX15_ENST00000301886.3_Intron	NM_001667.3	NP_001658.2	P36404	ARL2_HUMAN	ADP-ribosylation factor-like 2	126					cell cycle|centrosome organization|maintenance of protein location in nucleus|negative regulation of GTPase activity|positive regulation of cell-substrate adhesion|positive regulation of microtubule polymerization|small GTPase mediated signal transduction|tight junction assembly|tubulin complex assembly	centrosome|lateral plasma membrane|mitochondrial intermembrane space|nucleus	GTP binding|GTPase activity|GTPase inhibitor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	5						CTTTGCTAATAAGCAGGACCT	0.587000													4	29					0	0	1	0	0
PITX2	5308	broad.mit.edu	37	4	111542381	111542381	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:111542381G>A	ENST00000354925.2	-	6	2034	c.329C>T	c.(328-330)cCg>cTg	p.P110L	PITX2_ENST00000306732.3_Missense_Mutation_p.P117L|PITX2_ENST00000557119.2_Missense_Mutation_p.P117L|PITX2_ENST00000394598.2_Missense_Mutation_p.P110L|PITX2_ENST00000355080.5_Missense_Mutation_p.P64L|PITX2_ENST00000394595.3_Intron	NM_001204397.1	NP_001191326.1	Q99697	PITX2_HUMAN	paired-like homeodomain 2	110			P -> L (in RIEG1).|P -> R (in RIEG1).		determination of left/right symmetry|organ morphogenesis	transcription factor complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(1)|endometrium(3)|large_intestine(1)|lung(5)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00222)		GGACATGTCCGGGTAGCGGTT	0.622000													8	30					0	0	1	0	0
ZNF789	285989	broad.mit.edu	37	7	99084102	99084102	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr7:99084102C>G	ENST00000331410.5	+	5	539	c.269C>G	c.(268-270)tCt>tGt	p.S90C	ZNF789_ENST00000493485.1_Intron|ZNF789_ENST00000448667.1_3'UTR|ZNF789_ENST00000494186.1_Intron	NM_213603.2	NP_998768.2	Q5FWF6	ZN789_HUMAN	zinc finger protein 789	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)	11	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					TGGCTAGGTTCTGAAGCCAGA	0.373000													4	13					0	0	1	0	0
POLR2K	5440	broad.mit.edu	37	8	101164063	101164063	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr8:101164063G>A	ENST00000353107.3	+	3	208	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	POLR2K_ENST00000522439.1_Missense_Mutation_p.E25K|POLR2K_ENST00000519765.1_3'UTR	NM_005034.3	NP_005025.1	P53803	RPAB4_HUMAN	polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa	25					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|regulation of transcription from RNA polymerase I promoter|termination of RNA polymerase I transcription|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)	3	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.59e-09)|all cancers(13;1.74e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			GTGTCACACAGAAAATGAAAT	0.294000													4	18					0	0	1	0	0
TMEM106A	113277	broad.mit.edu	37	17	41365217	41365217	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:41365217G>A	ENST00000331615.3	+	3	394	c.157G>A	c.(157-159)Gat>Aat	p.D53N	TMEM106A_ENST00000592564.1_3'UTR|TMEM106A_ENST00000541594.1_Missense_Mutation_p.D5N|TMEM106A_ENST00000536052.1_Missense_Mutation_p.D53N|TMEM106A_ENST00000588659.1_Missense_Mutation_p.D53N	NM_145041.1	NP_659478.1	Q96A25	T106A_HUMAN	transmembrane protein 106A	53						integral to membrane		p.D53N(1)		NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		AGGAACTGCTGATGCCAGCTT	0.552000													11	116					0	0	1	0	0
USP33	23032	broad.mit.edu	37	1	78189060	78189060	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr1:78189060C>G	ENST00000370793.1	-	13	1784	c.1438G>C	c.(1438-1440)Gat>Cat	p.D480H	USP33_ENST00000370794.3_Missense_Mutation_p.D449H|USP33_ENST00000370792.3_Missense_Mutation_p.D480H|USP33_ENST00000357428.1_Missense_Mutation_p.D480H	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	480					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						ATTGTTCCATCAAATATGTCT	0.323000													14	40					0	0	1	0	0
EVC	2121	broad.mit.edu	37	4	5754640	5754640	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:5754640G>A	ENST00000382674.2	+	9	1360	c.1176G>A	c.(1174-1176)gaG>gaA	p.E392E	EVC_ENST00000264956.6_Silent_p.E392E|EVC_ENST00000509451.1_Silent_p.E392E			P57679	EVC_HUMAN	Ellis van Creveld syndrome	392					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				TCCAGGAGGAGACCAGGTGCC	0.627000													14	38					0	0	1	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433325	104433325	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr9:104433325C>T	ENST00000361820.3	-	3	1969	c.1369G>A	c.(1369-1371)Gtc>Atc	p.V457I		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	457					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCTGAGCTGACGATGGTGGAA	0.478000													40	148					0	0	1	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55340825	55340825	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:55340825G>T	ENST00000391728.4	+	7	1043	c.1010G>T	c.(1009-1011)aGa>aTa	p.R337I	KIR3DL1_ENST00000541392.1_Missense_Mutation_p.R320I|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.R337I|KIR3DL1_ENST00000326542.7_Missense_Mutation_p.R320I|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.R242I|KIR3DL1_ENST00000402254.2_Intron	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		GGTAACCCCAGACACCTGCAC	0.433000													10	84					0.00010058	0.000106986	1	1	0
ANAPC2	29882	broad.mit.edu	37	9	140077680	140077680	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr9:140077680C>G	ENST00000323927.2	-	6	1187	c.1183G>C	c.(1183-1185)Gac>Cac	p.D395H		NM_013366.3	NP_037498.1	Q9UJX6	ANC2_HUMAN	anaphase promoting complex subunit 2	395					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|regulation of cyclin-dependent protein kinase activity	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin protein ligase binding|ubiquitin-protein ligase activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.000858)		GTGATGATGTCACACGTGTTG	0.617000													40	138					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52309021	52309021	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:52309021C>G	ENST00000550683.1	+	6	928	c.827C>G	c.(826-828)tCa>tGa	p.S276*	ACVRL1_ENST00000419526.2_Nonsense_Mutation_p.S88*|ACVRL1_ENST00000388922.4_Nonsense_Mutation_p.S262*	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	262	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	TTCATCGCCTCAGACATGACC	0.617000													17	50					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3781195	3781195	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr16:3781195C>T	ENST00000262367.5	-	30	5979	c.5170G>A	c.(5170-5172)Gag>Aag	p.E1724K	CREBBP_ENST00000382070.3_Missense_Mutation_p.E1686K	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1724	Interaction with TRERF1.			ED -> VV (in Ref. 2; AAC51340).	cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GGGCCTACCTCGCACACAGTG	0.652000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						30	124					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	40					0	0	1	0	0
ITGA9	3680	broad.mit.edu	37	3	37565099	37565099	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr3:37565099C>T	ENST00000264741.5	+	12	1580	c.1324C>T	c.(1324-1326)Cct>Tct	p.P442S	ITGA9_ENST00000422441.1_Missense_Mutation_p.P442S	NM_002207.2	NP_002198.2	Q13797	ITA9_HUMAN	integrin, alpha 9	442					axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity	p.P442T(1)		breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(17)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|urinary_tract(1)	44				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		AAATGGCTATCCTGGTAAGCT	0.383000													7	65					0	0	1	0	0
GEMIN4	50628	broad.mit.edu	37	17	650277	650277	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:650277G>A	ENST00000576778.1	-	1	2314	c.973C>T	c.(973-975)Cgc>Tgc	p.R325C	GEMIN4_ENST00000437269.1_3'UTR|GEMIN4_ENST00000319004.5_Missense_Mutation_p.R336C			P57678	GEMI4_HUMAN	gem (nuclear organelle) associated protein 4	336					rRNA processing|spliceosomal snRNP assembly	Cajal body|cytosol|nucleolus|small nuclear ribonucleoprotein complex|spliceosomal complex	protein binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.022)		TGGCTGCTGCGGAGCACGGCC	0.632000													7	41					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612192	20612192	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr14:20612192C>G	ENST00000333629.1	+	1	298	c.298C>G	c.(298-300)Cag>Gag	p.Q100E		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CTGCATCACTCAGCTCTTTTT	0.493000													9	75					0	0	1	0	0
SUV420H1	51111	broad.mit.edu	37	11	67925781	67925781	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:67925781C>G	ENST00000304363.4	-	11	2385	c.2032G>C	c.(2032-2034)Gtg>Ctg	p.V678L		NM_017635.3	NP_060105.3	Q4FZB7	SV421_HUMAN	suppressor of variegation 4-20 homolog 1 (Drosophila)	678					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(9)|lung(15)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						TCTGATGTCACAACTGAACAA	0.463000													10	34					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117884826	117884826	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr10:117884826G>A	ENST00000439649.3	-	5	1028	c.661C>T	c.(661-663)Cga>Tga	p.R221*	GFRA1_ENST00000369236.1_Nonsense_Mutation_p.R221*|GFRA1_ENST00000355422.6_Nonsense_Mutation_p.R226*|GFRA1_ENST00000544592.1_Nonsense_Mutation_p.R105*	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	226					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		ATGGTCTGTCGCCTCCGCTCT	0.562000													9	44					0	0	1	0	0
NEFH	4744	broad.mit.edu	37	22	29885739	29885739	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:29885739T>A	ENST00000310624.6	+	4	2143	c.2110T>A	c.(2110-2112)Tcc>Acc	p.S704T		NM_021076.3	NP_066554.2	P12036	NFH_HUMAN	neurofilament, heavy polypeptide	710	30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]- [AEVK].|Tail.				cell death|nervous system development	neurofilament				cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|skin(3)	30						AGAAGCAAAGTCCCCTGAGAA	0.557000													6	126					0	0	1	0	0
RICTOR	253260	broad.mit.edu	37	5	38950389	38950389	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr5:38950389C>G	ENST00000357387.3	-	31	3591	c.3561G>C	c.(3559-3561)aaG>aaC	p.K1187N	RICTOR_ENST00000296782.5_Missense_Mutation_p.K1187N	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1187					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TACCAAAATTCTTGGTGAATT	0.363000													24	176					0	0	1	0	0
ANKRD49	54851	broad.mit.edu	37	11	94230131	94230131	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:94230131T>A	ENST00000544253.1	+	2	390	c.272T>A	c.(271-273)aTt>aAt	p.I91N	ANKRD49_ENST00000540349.1_Missense_Mutation_p.I91N|ANKRD49_ENST00000302755.4_Intron|ANKRD49_ENST00000544612.1_Intron			Q8WVL7	ANR49_HUMAN	ankyrin repeat domain 49	0					positive regulation of transcription, DNA-dependent					autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|urinary_tract(1)	12		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AAAAAAAAAATTACAGAGGGA	0.398000													4	83					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56466501	56466501	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:56466501G>A	ENST00000291971.3	+	3	1148	c.1077G>A	c.(1075-1077)acG>acA	p.T359T	NLRP8_ENST00000590542.1_Silent_p.T359T	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	359	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GGTTTAATACGATGGAAAAAA	0.453000													28	60					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													3	24					0	0	1	0	0
TAPT1	202018	broad.mit.edu	37	4	16188416	16188416	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr4:16188416C>T	ENST00000405303.2	-	6	917	c.834G>A	c.(832-834)atG>atA	p.M278I	TAPT1_ENST00000508888.1_5'UTR|TAPT1_ENST00000399920.3_Missense_Mutation_p.M167I|TAPT1_ENST00000304584.8_Intron	NM_153365.2	NP_699196.2	Q6NXT6	TAPT1_HUMAN	transmembrane anterior posterior transformation 1	278						integral to membrane	growth hormone-releasing hormone receptor activity			NS(1)|breast(2)|cervix(1)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)	10						TATTAGACATCATGATAGTAA	0.318000													4	28					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058353	11058353	+	RNA	SNP	T	T	C	rs79433933	by1000genomes	TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr21:11058353T>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GAAATCTCTTTATAAAACCTT	0.343000													8	83					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96964614	96964614	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:96964614C>T	ENST00000323853.5	-	7	898	c.821G>A	c.(820-822)cGt>cAt	p.R274H	SNRNP200_ENST00000349783.5_Missense_Mutation_p.R274H	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	274						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						ATCATAGAAACGACTGAGCTG	0.438000													35	78					0	0	1	0	0
SALL4	57167	broad.mit.edu	37	20	50407635	50407635	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr20:50407635C>G	ENST00000217086.4	-	2	1498	c.1387G>C	c.(1387-1389)Gac>Cac	p.D463H	SALL4_ENST00000395997.3_Intron|SALL4_ENST00000371539.3_Intron	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	463					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TCTATGGGGTCAGGTACAGAG	0.532000													23	128					0	0	1	0	0
APOBEC3A	200315	broad.mit.edu	37	22	39357577	39357577	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:39357577G>A	ENST00000402255.1	+	4	564	c.360G>A	c.(358-360)gtG>gtA	p.V120V	APOBEC3A_ENST00000249116.2_Silent_p.V120V					apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A											large_intestine(1)|lung(2)|ovary(1)|skin(1)	5	Melanoma(58;0.04)					ACACACACGTGAGACTGCGTA	0.572000													46	131					0	0	1	0	0
CCDC64	92558	broad.mit.edu	37	12	120510439	120510439	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:120510439C>T	ENST00000397558.2	+	6	1214	c.1214C>T	c.(1213-1215)tCg>tTg	p.S405L	CCDC64_ENST00000257583.4_Missense_Mutation_p.S54L|CCDC64_ENST00000446727.2_Intron	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	405					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCAGAAACCTCGTCCGCCAAG	0.567000													15	54					0	0	1	0	0
RADIL	55698	broad.mit.edu	37	7	4917450	4917450	+	Silent	SNP	G	G	A			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr7:4917450G>A	ENST00000399583.3	-	2	508	c.321C>T	c.(319-321)gcC>gcT	p.A107A	RADIL_ENST00000536091.1_Silent_p.A107A	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	107	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGTACTGGCCGGCCTGCCTGG	0.692000													12	88					0	0	1	0	0
OOSP2	219990	broad.mit.edu	37	11	59812153	59812153	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr11:59812153G>C	ENST00000278855.2	+	3	438	c.253G>C	c.(253-255)Gag>Cag	p.E85Q	PLAC1L_ENST00000532905.1_Missense_Mutation_p.E54Q	NM_173801.3	NP_776162.2	Q86WS3	PLACL_HUMAN		85						extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						GGTAGTTTCTGAGGAAACTCT	0.398000													7	34					0	0	1	0	0
RNF41	10193	broad.mit.edu	37	12	56600242	56600242	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr12:56600242C>G	ENST00000345093.4	-	7	1312	c.943G>C	c.(943-945)Gaa>Caa	p.E315Q	RNF41_ENST00000394013.2_Missense_Mutation_p.E244Q|RNF41_ENST00000552656.1_Missense_Mutation_p.E315Q	NM_005785.3|NM_194359.2	NP_005776.1|NP_919340.1	Q9H4P4	RNF41_HUMAN	ring finger protein 41	315					apoptosis|induction of apoptosis|protein polyubiquitination|regulation of reactive oxygen species metabolic process		protein binding|protein tag|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	11						TATATCTCTTCCACGCCATGC	0.512000											OREG0021921	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	144					0	0	1	0	0
SLC9A3R1	9368	broad.mit.edu	37	17	72759559	72759559	+	Silent	SNP	C	C	T	rs147104235	byFrequency	TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr17:72759559C>T	ENST00000262613.5	+	3	852	c.657C>T	c.(655-657)atC>atT	p.I219I	SLC9A3R1_ENST00000413388.2_Silent_p.I63I	NM_004252.4	NP_004243.1	O14745	NHRF1_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	219	PDZ 2.				apoptosis|bile acid secretion|glutathione transport|microvillus assembly|negative regulation of cell proliferation|negative regulation of ERK1 and ERK2 cascade|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|protein complex assembly|regulation of protein kinase activity|regulation of sodium:hydrogen antiporter activity|renal absorption|Wnt receptor signaling pathway	actin cytoskeleton|apical plasma membrane|centrosome|endomembrane system|filopodium|intracellular membrane-bounded organelle|microvillus membrane|ruffle	beta-2 adrenergic receptor binding|beta-catenin binding|chloride channel regulator activity|growth factor receptor binding|PDZ domain binding|phosphatase binding|protein self-association			large_intestine(4)	4						TGTCCGCCATCAGGGCTGGCG	0.607000													8	23					0	0	1	0	0
CRELD2	79174	broad.mit.edu	37	22	50315265	50315265	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr22:50315265G>T	ENST00000404488.3	+	5	583	c.448G>T	c.(448-450)Ggg>Tgg	p.G150W	CRELD2_ENST00000407217.3_Missense_Mutation_p.G150W|CRELD2_ENST00000328268.4_Missense_Mutation_p.G150W|CRELD2_ENST00000403427.3_Missense_Mutation_p.G150W|CRELD2_ENST00000444954.1_3'UTR	NM_001135101.1	NP_001128573.1	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2	150	EGF-like 1.					endoplasmic reticulum|extracellular region	calcium ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|stomach(3)	9		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		GCCCTGCAGCGGGAATGGCCA	0.652000													3	60					1	1	1	1	0
LINGO3	645191	broad.mit.edu	37	19	2290251	2290251	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:2290251C>G	ENST00000585527.1	-	1	1772	c.1525G>C	c.(1525-1527)Gag>Cag	p.E509Q	LINGO3_ENST00000404279.1_Missense_Mutation_p.E509Q			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	509						integral to membrane				lung(1)|urinary_tract(1)	2						TTGTGGGCCTCGCCCGGGGTC	0.726000													4	26					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770038	31770038	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:31770038C>T	ENST00000240587.4	-	2	988	c.661G>A	c.(661-663)Gct>Act	p.A221T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	221					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					TCGTAGGCAGCGCTGCAGTCC	0.602000													13	146					0	0	1	0	0
ALS2CR11	151254	broad.mit.edu	37	2	202352352	202352352	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:202352352delT	ENST00000439140.1	-	16	5490	c.5446delA	c.(5446-5448)ttfs	p.I1816fs	ALS2CR11_ENST00000439802.1_3'UTR|ALS2CR11_ENST00000286195.3_Frame_Shift_Del_p.I619fs	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	619										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						CCTCTTTTAATTTTTTTTGGC	0.323													7	54	---	---	---	---					
NBEAL1	65065	broad.mit.edu	37	2	204030880	204030882	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr2:204030880_204030882delAAG	ENST00000449802.1	+	36	5969_5971	c.5636_5638delAAG	c.(5635-5640)aaa>a	p.KE1879del		NM_001114132.1	NP_001107604.1	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1	1879							binding			NS(1)|breast(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						AGTGATGAGAAAGAAGAACAGGA	0.281													15	33	---	---	---	---					
MAFA	389692	broad.mit.edu	37	8	144511954	144511956	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr8:144511954_144511956delTGG	ENST00000333480.2	-	1	620_622	c.621_623delCCA	c.(619-624)cat>ca	p.HH207del	MAFA_ENST00000528185.1_5'UTR	NM_201589.3	NP_963883.2	Q8NHW3	MAFA_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	207	His-rich.				insulin secretion|nitric oxide mediated signal transduction|response to glucose stimulus	nucleus	protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.H208delH(3)		breast(1)|lung(1)|upper_aerodigestive_tract(2)	4	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.237)			CGCGCCGCCAtggtggtggtggt	0.744										HNSCC(29;0.082)			2	4	---	---	---	---					
LRRC14	9684	broad.mit.edu	37	8	145746499	145746502	+	Frame_Shift_Del	DEL	TGAG	TGAG	-			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr8:145746499_145746502delTGAG	ENST00000292524.1	+	4	1265_1268	c.1119_1122delTGAG	c.(1117-1122)acfs	p.TE373fs	LRRC14_ENST00000529022.1_Frame_Shift_Del_p.TE373fs	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	373										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGAGCTGACTGAGTGTCAGCTCG	0.593													10	50	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													2	4	---	---	---	---					
CD37	951	broad.mit.edu	37	19	49841253	49841253	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chr19:49841253delG	ENST00000535669.2	+	5	528	c.414delG	c.(412-414)gcfs	p.A139fs	CD37_ENST00000323906.4_Frame_Shift_Del_p.A139fs|CD37_ENST00000598095.1_Frame_Shift_Del_p.A71fs|CTC-301O7.4_ENST00000358234.4_lincRNA|CD37_ENST00000426897.2_Frame_Shift_Del_p.A71fs|CD37_ENST00000596426.1_3'UTR			P11049	CD37_HUMAN	CD37 molecule	139						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	11		all_lung(116;2.81e-06)|Lung NSC(112;5.89e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00088)|GBM - Glioblastoma multiforme(486;0.0443)		AGGAGACCGCGGCCGAGGAGA	0.632													17	49	---	---	---	---					
RNA5-8SP6	100873336	broad.mit.edu	37	Y	10037863	10037863	+	RNA	DEL	C	C	-			TCGA-55-7726-01A-11D-2167-08	TCGA-55-7726-10A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8928b562-7e58-4619-868f-5be53aeec89f	5f0443ea-b942-439d-bd2e-f2a7b8e6b678	g.chrY:10037863delC	ENST00000515896.1	+	0	100																											ATCGACACTTCGAACGCACTT	0.552													7	31	---	---	---	---