Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RAPGEF2	9693	broad.mit.edu	37	4	160277129	160277129	+	Silent	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:160277129C>G	ENST00000264431.4	+	23	4712	c.4293C>G	c.(4291-4293)gcC>gcG	p.A1431A		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1431					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		ACAACGTGGCCCTTCAGAGAT	0.612000													5	28					0	0	1	0	0
CTPS1	1503	broad.mit.edu	37	1	41475253	41475253	+	Silent	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:41475253C>T	ENST00000372621.4	+	17	2191	c.1683C>T	c.(1681-1683)ctC>ctT	p.L561L	CTPS1_ENST00000372616.1_Silent_p.L561L|CTPS1_ENST00000541520.1_Silent_p.L330L	NM_001905.2	NP_001896.2	P17812	PYRG1_HUMAN	CTP synthase 1	561					CTP biosynthetic process|glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|response to drug	cytosol	ATP binding|CTP synthase activity|protein binding			endometrium(3)|lung(10)	13					L-Glutamine(DB00130)	GCTGCAGGCTCTCACCCAGGT	0.537000													14	110					0	0	1	0	0
NKX3-2	579	broad.mit.edu	37	4	13546026	13546026	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:13546026C>T	ENST00000382438.5	-	1	648	c.13G>A	c.(13-15)Ggc>Agc	p.G5S		NM_001189.3	NP_001180.1	P78367	NKX32_HUMAN	NK3 homeobox 2	5					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)|lung(4)|prostate(1)	7						GTGTTGGCGCCGCGCACAGCC	0.771000													5	8					0	0	1	0	0
CCDC146	57639	broad.mit.edu	37	7	76871034	76871034	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:76871034T>A	ENST00000285871.4	+	4	393	c.266T>A	c.(265-267)cTa>cAa	p.L89Q	CCDC146_ENST00000431197.1_5'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	89										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				GTCCAACTGCTACAGAATGCC	0.473000													20	57					0	0	1	0	0
NEDD4L	23327	broad.mit.edu	37	18	55998078	55998078	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr18:55998078T>C	ENST00000456986.1	+	11	1159	c.559T>C	c.(559-561)Tca>Cca	p.S187P	NEDD4L_ENST00000589054.1_Intron|NEDD4L_ENST00000435432.2_Missense_Mutation_p.S187P|NEDD4L_ENST00000586263.1_Missense_Mutation_p.S300P|NEDD4L_ENST00000256832.7_Missense_Mutation_p.S187P|NEDD4L_ENST00000382850.4_Missense_Mutation_p.S308P|NEDD4L_ENST00000431212.2_Missense_Mutation_p.S187P|NEDD4L_ENST00000357895.5_Missense_Mutation_p.S300P|NEDD4L_ENST00000256830.9_Missense_Mutation_p.S308P|NEDD4L_ENST00000400345.3_Missense_Mutation_p.S308P|NEDD4L_ENST00000456173.2_Missense_Mutation_p.S187P|NEDD4L_ENST00000356462.6_Missense_Mutation_p.S308P	NM_001144964.1	NP_001138436.1	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	308					cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						TCAGGAGCTGTCAGAGGAACT	0.532000													27	42					0	0	1	0	0
CRHBP	1393	broad.mit.edu	37	5	76264684	76264684	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr5:76264684G>T	ENST00000274368.4	+	7	1365	c.943G>T	c.(943-945)Ggg>Tgg	p.G315W	CRHBP_ENST00000514258.1_Intron	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	315					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		AAACAGTATCGGGGAATTCTG	0.438000													15	47					6.49762e-13	8.34498e-13	1	1	0
GRID2	2895	broad.mit.edu	37	4	94344000	94344000	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:94344000G>A	ENST00000282020.4	+	10	1684	c.1426G>A	c.(1426-1428)Gat>Aat	p.D476N	GRID2_ENST00000510992.1_Missense_Mutation_p.D381N	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	476					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TGATGTTTTGGATGCCTTATC	0.418000													4	47					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92761099	92761099	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:92761099T>C	ENST00000318238.4	-	5	5402	c.4186A>G	c.(4186-4188)Aac>Gac	p.N1396D	SAMD9L_ENST00000437805.1_Missense_Mutation_p.N1396D|SAMD9L_ENST00000411955.1_Missense_Mutation_p.N1396D	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1396										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AACTTGGAGTTGGGCTTTAGA	0.378000													54	139					0	0	1	0	0
MIR1185-2	100302209	broad.mit.edu	37	14	101510597	101510597	+	RNA	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr14:101510597G>T	ENST00000408687.1	+	0	63					NR_031571.1																						ATATACAGGGGGAGACTCTCA	0.502000													13	47					2.32078e-09	2.7892e-09	1	1	0
KIF13B	23303	broad.mit.edu	37	8	29018290	29018290	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr8:29018290G>A	ENST00000524189.1	-	13	1402	c.1364C>T	c.(1363-1365)gCt>gTt	p.A455V	KIF13B_ENST00000521515.1_Missense_Mutation_p.A455V	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	455					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		AGCTGGGTCAGCATTCAGATT	0.388000													3	46					0	0	1	0	0
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr12:2062350C>G	ENST00000280665.6	-	7	835	c.756G>C	c.(754-756)caG>caC	p.Q252H	DCP1B_ENST00000540622.1_Missense_Mutation_p.Q126H|DCP1B_ENST00000541700.1_5'UTR|DCP1B_ENST00000397173.4_Missense_Mutation_p.Q150H	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.552000													3	39					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113702222	113702222	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr8:113702222C>G	ENST00000297405.5	-	14	2274	c.2030G>C	c.(2029-2031)gGc>gCc	p.G677A	CSMD3_ENST00000455883.2_Missense_Mutation_p.G573A|CSMD3_ENST00000352409.3_Missense_Mutation_p.G677A|CSMD3_ENST00000343508.3_Missense_Mutation_p.G637A	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	677	Sushi 3.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAATCCATCGCCTTCTCTAAT	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			49	173					0	0	1	0	0
NOS1AP	9722	broad.mit.edu	37	1	162336986	162336986	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:162336986G>T	ENST00000493151.1	+	2	2732	c.365G>T	c.(364-366)aGc>aTc	p.S122I	RP11-565P22.6_ENST00000431696.1_Missense_Mutation_p.S103I|NOS1AP_ENST00000454693.1_3'UTR|NOS1AP_ENST00000530878.1_Missense_Mutation_p.S412I|NOS1AP_ENST00000361897.5_Missense_Mutation_p.S417I	NM_001126060.1	NP_001119532.2	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	417	PID.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			CCTGCGGGCAGCCCCTTAGGT	0.701000													43	49					1.47857e-17	2.08272e-17	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367483.4_Silent_p.K669K|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367485.4_Silent_p.K617K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													5	140					0	0	1	0	0
TGM2	7052	broad.mit.edu	37	20	36759493	36759493	+	Splice_Site	SNP	A	A	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr20:36759493A>T	ENST00000361475.2	-	12	2087		c.e12+1		TGM2_ENST00000536724.1_Splice_Site|TGM2_ENST00000536701.1_Splice_Site	NM_004613.2|NM_198951.1	NP_004604.2|NP_945189.1	P21980	TGM2_HUMAN	transglutaminase 2						apoptotic cell clearance|peptide cross-linking|positive regulation of cell adhesion		acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			endometrium(2)|large_intestine(11)|liver(1)|lung(7)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.00878)			L-Glutamine(DB00130)	GCCAGCACTTACATCTCCACC	0.627000													15	76					0	0	1	0	0
CT47A6	728062	broad.mit.edu	37	X	120094385	120094385	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:120094385G>C	ENST00000443600.2	-	1	952	c.698C>G	c.(697-699)cCa>cGa	p.P233R	CT47A5_ENST00000419194.2_Intron	NM_001080141.1	NP_001073610.1	Q5JQC4	CT47A_HUMAN	cancer/testis antigen family 47, member A6	233										large_intestine(1)|lung(4)	5						TTCTGTGGCTGGTTCCTCTGC	0.687000													4	9					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47040923	47040923	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:47040923G>T	ENST00000377604.3	+	14	2195	c.1453G>T	c.(1453-1455)Gag>Tag	p.E485*	RBM10_ENST00000329236.7_Nonsense_Mutation_p.E407*|RBM10_ENST00000468791.1_Intron|RBM10_ENST00000345781.6_Nonsense_Mutation_p.E408*	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	485					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						GGCCTCCCTAGAGCCTGGGGC	0.632000													15	8					8.00594e-06	8.73982e-06	1	1	0
FLT1	2321	broad.mit.edu	37	13	28897003	28897003	+	Missense_Mutation	SNP	G	G	T	rs145985203		TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr13:28897003G>T	ENST00000282397.4	-	21	3128	c.2877C>A	c.(2875-2877)agC>agA	p.S959R	FLT1_ENST00000540678.1_Missense_Mutation_p.S177R	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	959	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TGCTGGTGACGCTATCTAGTC	0.478000													31	78					1.99505e-19	2.84078e-19	1	1	0
CCDC88A	55704	broad.mit.edu	37	2	55615934	55615934	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:55615934G>A	ENST00000436346.1	-	3	1094	c.253C>T	c.(253-255)Cag>Tag	p.Q85*	CCDC88A_ENST00000263630.8_Nonsense_Mutation_p.Q85*|CCDC88A_ENST00000336838.6_Nonsense_Mutation_p.Q85*|CCDC88A_ENST00000413716.2_Nonsense_Mutation_p.Q85*	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	85					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						AATTTTATCTGTCTCACCAAA	0.289000													31	80					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638622	234638622	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:234638622A>G	ENST00000482026.1	+	1	869	c.850A>G	c.(850-852)Agg>Ggg	p.R284G	UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A5_ENST00000373414.3_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTGTGCCAACAGGAAGCCACT	0.438000													3	158					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45795221	45795221	+	Silent	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr22:45795221G>A	ENST00000357450.4	-	6	866	c.867C>T	c.(865-867)acC>acT	p.T289T	SMC1B_ENST00000404354.3_Silent_p.T289T	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	289					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		GATTTAAAAGGGTTTCAACCG	0.323000													13	37					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	74019646	74019646	+	Silent	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:74019646C>A	ENST00000358602.4	-	6	1301	c.1185G>T	c.(1183-1185)acG>acT	p.T395T	ANKRD17_ENST00000509867.2_Silent_p.T282T|ANKRD17_ENST00000514252.1_5'UTR|ANKRD17_ENST00000330838.6_Silent_p.T395T	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	395					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			CATTAGAATGCGTATTAATGC	0.363000													4	150					0.217242	0.217242	1	1	0
CDKL5	6792	broad.mit.edu	37	X	18622571	18622571	+	Silent	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:18622571G>T	ENST00000379989.3	+	13	1812	c.1527G>T	c.(1525-1527)gcG>gcT	p.A509A	CDKL5_ENST00000463994.1_3'UTR|CDKL5_ENST00000379996.3_Silent_p.A509A	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	509					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					CCCAAATTGCGGAGCCCAGTA	0.547000													73	68					2.14232e-31	3.15331e-31	1	1	0
PTPRG	5793	broad.mit.edu	37	3	62262672	62262672	+	Silent	SNP	A	A	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:62262672A>C	ENST00000474889.1	+	25	3962	c.3585A>C	c.(3583-3585)gcA>gcC	p.A1195A	PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG-AS1_ENST00000475371.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000466893.1_RNA|PTPRG_ENST00000295874.10_Silent_p.A1166A|PTPRG-AS1_ENST00000490916.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1195	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		TGGGTCTTGCACCATTGCCTG	0.368000													12	50					0	0	1	0	0
FOXP1	27086	broad.mit.edu	37	3	71026123	71026123	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:71026123G>A	ENST00000318789.4	-	17	2024	c.1499C>T	c.(1498-1500)gCt>gTt	p.A500V	FOXP1_ENST00000498215.1_Missense_Mutation_p.A500V|FOXP1_ENST00000484350.1_Missense_Mutation_p.A424V|FOXP1_ENST00000468577.1_Missense_Mutation_p.A500V|FOXP1_ENST00000493089.1_Missense_Mutation_p.A499V|FOXP1_ENST00000491238.1_Missense_Mutation_p.A502V|FOXP1_ENST00000475937.1_Missense_Mutation_p.A500V	NM_001244810.1|NM_001244813.1|NM_032682.5	NP_001231739.1|NP_001231742.1|NP_116071.2	Q9H334	FOXP1_HUMAN	forkhead box P1	500					cardiac muscle cell differentiation|embryo development|immunoglobulin V(D)J recombination|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of immunoglobulin production|positive regulation of mesenchymal cell proliferation|pre-B cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|skeletal muscle tissue development|smooth muscle tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	31		Lung NSC(201;4.62e-05)|Prostate(10;0.0181)|Hepatocellular(537;0.186)|Myeloproliferative disorder(1037;0.209)		BRCA - Breast invasive adenocarcinoma(55;1.17e-05)|Epithelial(33;1.39e-05)|LUSC - Lung squamous cell carcinoma(21;2.35e-05)|Lung(16;4.26e-05)		TCGGAAGTAAGCAAACATTCG	0.413000			T	PAX5	ALL								9	78					0	0	1	0	0
ADRA1D	146	broad.mit.edu	37	20	4229135	4229135	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr20:4229135T>C	ENST00000379453.4	-	1	586	c.470A>G	c.(469-471)gAg>gGg	p.E157G		NM_000678.3	NP_000669.1	P25100	ADA1D_HUMAN	adrenoceptor alpha 1D	157					cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	14					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	GCCCAGAACCTCCATGGTGGC	0.647000													9	11					0	0	1	0	0
MSL3	10943	broad.mit.edu	37	X	11790366	11790366	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:11790366G>A	ENST00000380693.3	+	10	1512	c.875G>A	c.(874-876)cGa>cAa	p.R292Q	MSL3_ENST00000361672.2_Missense_Mutation_p.R309Q|MSL3_ENST00000312196.4_Missense_Mutation_p.R458Q|MSL3_ENST00000398527.2_Missense_Mutation_p.R446Q	NM_006800.3	NP_006791.2	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	458					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						CATTTGCTGCGATTGTTTGGT	0.453000													71	37					0	0	1	0	0
KLHL14	57565	broad.mit.edu	37	18	30260434	30260434	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr18:30260434G>T	ENST00000359358.4	-	6	1805	c.1367C>A	c.(1366-1368)tCt>tAt	p.S456Y		NM_020805.1	NP_065856.1	Q9P2G3	KLH14_HUMAN	kelch-like family member 14	456						cytosol|endoplasmic reticulum membrane				breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(20)|ovary(2)	31						CTGTGGCAAAGAGGACACATA	0.453000													17	113					0.00121646	0.00125478	1	1	0
SLC6A14	11254	broad.mit.edu	37	X	115574910	115574910	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:115574910G>A	ENST00000371900.4	+	5	696	c.608G>A	c.(607-609)gGc>gAc	p.G203D		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	203					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	TGCATCAACGGCAGTGAAATT	0.343000													10	74					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83933324	83933324	+	Missense_Mutation	SNP	G	G	A	rs150744545		TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:83933324G>A	ENST00000345382.2	-	4	764	c.679C>T	c.(679-681)Ccc>Tcc	p.P227S	BNC1_ENST00000569704.1_Missense_Mutation_p.P220S|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	227					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						ATACTGCTGGGGTTTCCTTTG	0.493000													22	58					0	0	1	0	0
RRAGD	58528	broad.mit.edu	37	6	90077868	90077868	+	Silent	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr6:90077868C>T	ENST00000369415.4	-	7	1386	c.1110G>A	c.(1108-1110)gtG>gtA	p.V370V	RRAGD_ENST00000359203.2_Silent_p.V219V	NM_021244.4	NP_067067.1	Q9NQL2	RRAGD_HUMAN	Ras-related GTP binding D	370					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade	lysosome|nucleus	GTP binding|protein heterodimerization activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(2)	15		all_cancers(76;7.01e-07)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00139)		BRCA - Breast invasive adenocarcinoma(108;0.0144)		CTTTCATTCTCACCTCAAAAA	0.408000											OREG0017566	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	61					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000584398.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	117					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55433392	55433392	+	Silent	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:55433392C>T	ENST00000314259.3	+	1	779	c.750C>T	c.(748-750)gtC>gtT	p.V250V		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TGTTCTTTGTCCCCTGTATTT	0.502000													26	137					0	0	1	0	0
OSBP2	23762	broad.mit.edu	37	22	31091088	31091088	+	Silent	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr22:31091088G>T	ENST00000332585.6	+	1	296	c.192G>T	c.(190-192)ccG>ccT	p.P64P	OSBP2_ENST00000407373.1_Intron|OSBP2_ENST00000446658.2_Silent_p.P64P|OSBP2_ENST00000403222.3_Intron|OSBP2_ENST00000382310.3_Silent_p.P64P	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	64					lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						AGCGGGGACCGCTGTCAGAAC	0.711000													5	20					0.000602214	0.000626112	1	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64608232	64608232	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:64608232A>G	ENST00000498707.1	-	17	2762	c.2420T>C	c.(2419-2421)cTa>cCa	p.L807P	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.L779P	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	807	Spacer.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		GTTTCCATTTAGCAAGAATTC	0.393000													22	42					0	0	1	0	0
GRIN2B	2904	broad.mit.edu	37	12	13717356	13717356	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr12:13717356C>T	ENST00000279593.3	-	13	3025	c.2816G>A	c.(2815-2817)cGc>cAc	p.R939H		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	939					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGTGAAGCTGCGGCGGTGCTC	0.542000													46	139					0	0	1	0	0
AC015849.16	0	broad.mit.edu	37	17	34236038	34236038	+	RNA	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr17:34236038G>T	ENST00000587132.1	-	0	1989																											CATCGGGGCTGTAGAAGGGCA	0.498000													12	47					2.61681e-11	3.26479e-11	1	1	0
FNDC7	163479	broad.mit.edu	37	1	109271482	109271482	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:109271482C>A	ENST00000370017.3	+	8	1875	c.1598C>A	c.(1597-1599)cCc>cAc	p.P533H	FNDC7_ENST00000271311.2_Missense_Mutation_p.P534H	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	534	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CGGAGCCTGCCCAGCTACAGT	0.562000													8	46					0.0692343	0.0697669	1	1	0
UBN1	29855	broad.mit.edu	37	16	4924403	4924403	+	Silent	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr16:4924403C>T	ENST00000396658.4	+	14	2695	c.1992C>T	c.(1990-1992)gaC>gaT	p.D664D	UBN1_ENST00000545171.1_Silent_p.D664D|UBN1_ENST00000590769.1_Silent_p.D664D|UBN1_ENST00000262376.6_Silent_p.D664D	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	664					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						TGGATGAAGACTTGATCCGCA	0.577000													40	130					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31447621	31447621	+	Silent	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:31447621A>G	ENST00000373747.3	-	10	1485	c.1386T>C	c.(1384-1386)taT>taC	p.Y462Y	PUM1_ENST00000490546.1_5'UTR|PUM1_ENST00000257075.5_Silent_p.Y461Y|PUM1_ENST00000426105.2_Silent_p.Y461Y|PUM1_ENST00000424085.2_Silent_p.Y219Y|PUM1_ENST00000423018.2_Silent_p.Y365Y|PUM1_ENST00000440538.2_Silent_p.Y462Y|PUM1_ENST00000373741.4_Silent_p.Y497Y|PUM1_ENST00000373742.2_Silent_p.Y402Y	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	461	Ala-rich.				cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		GAGTAACTCCATAATACTGGT	0.488000													4	23					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699040	17699040	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:17699040T>C	ENST00000399080.2	-	1	666	c.643A>G	c.(643-645)Aac>Gac	p.N215D		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	215										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ACAACACTGTTAGCTTTACAT	0.318000													14	47					0	0	1	0	0
SPINK2	6691	broad.mit.edu	37	4	57686701	57686701	+	Splice_Site	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:57686701C>T	ENST00000506738.1	-	2	329		c.e2+1		SPINK2_ENST00000248701.4_Splice_Site|SPINK2_ENST00000504762.1_Splice_Site	NM_001271718.1	NP_001258647.1	P20155	ISK2_HUMAN	serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)							extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(2)	4	Glioma(25;0.08)|all_neural(26;0.181)					TTGCTACTTACCGTTCTATAT	0.413000													15	50					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158436099	158436099	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:158436099G>A	ENST00000289451.2	+	1	828	c.748G>A	c.(748-750)Gtt>Att	p.V250I		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TGTGGTAACTGTTCACTACAG	0.458000													34	55					0	0	1	0	0
DCHS1	8642	broad.mit.edu	37	11	6661629	6661629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:6661629C>A	ENST00000299441.3	-	2	1627	c.1216G>T	c.(1216-1218)Gaa>Taa	p.E406*		NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	406	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTCCACCTTCCAGGGACACA	0.582000													7	18					2.7689e-08	3.23862e-08	1	1	0
LILRB2	10288	broad.mit.edu	37	19	54781435	54781435	+	Silent	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr19:54781435G>T	ENST00000391748.1	-	9	1453	c.1326C>A	c.(1324-1326)ccC>ccA	p.P442P	LILRB2_ENST00000391749.4_Silent_p.P443P|LILRB2_ENST00000391746.1_Silent_p.P443P|LILRB2_ENST00000314446.5_Silent_p.P442P|LILRB2_ENST00000434421.1_Silent_p.P327P	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	443					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TGGGGGTGAGGGGCTGGTCCT	0.716000													4	8					0.000602214	0.000626112	1	1	0
L3MBTL4	91133	broad.mit.edu	37	18	6243370	6243370	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr18:6243370C>A	ENST00000400104.3	-	7	583	c.383G>T	c.(382-384)tGg>tTg	p.W128L	L3MBTL4_ENST00000284898.6_Missense_Mutation_p.W128L|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.W128L|L3MBTL4_ENST00000317931.7_Missense_Mutation_p.W128L			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	128					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				AGCATTGGTCCAAAAATCATA	0.388000													16	88					1.50039e-11	1.88992e-11	1	1	0
EID1	23741	broad.mit.edu	37	15	49170852	49170852	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:49170852C>G	ENST00000530028.2	+	1	770	c.479C>G	c.(478-480)gCt>gGt	p.A160G	EID1_ENST00000558295.1_Intron|SHC4_ENST00000332408.4_Intron|EID1_ENST00000560490.1_Missense_Mutation_p.A138G	NM_014335.2	NP_055150.1	Q9Y6B2	EID1_HUMAN	EP300 interacting inhibitor of differentiation 1	160					cell cycle|cell differentiation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	histone acetyltransferase binding|histone acetyltransferase regulator activity|transcription corepressor activity			liver(1)|prostate(1)	2		all_lung(180;0.00455)		all cancers(107;2.73e-08)|GBM - Glioblastoma multiforme(94;9.58e-07)		GATCAGTTAGCTTTTATCGAA	0.433000													16	32					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182844009	182844009	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:182844009A>G	ENST00000367549.3	+	16	1845	c.1735A>G	c.(1735-1737)Att>Gtt	p.I579V		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	579					CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GGAAGACTGCATTCAGATGAC	0.388000													50	82					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39379609	39379609	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:39379609C>A	ENST00000518318.2	+	5	922	c.880C>A	c.(880-882)Cta>Ata	p.L294I	POU6F2_ENST00000559001.1_Missense_Mutation_p.L286I|POU6F2_ENST00000517348.1_3'UTR|POU6F2_ENST00000403058.1_Missense_Mutation_p.L294I			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	294	Gln-rich.				central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						ACCCAATCCTCTACAGGTATG	0.602000													31	90					4.11147e-13	5.3327e-13	1	1	0
CCT6P3	643180	broad.mit.edu	37	7	64498882	64498882	+	RNA	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:64498882G>T	ENST00000426828.1	+	0	145					NR_033416.1																						GCGGGACCCCGAGCACCGGGC	0.711000													7	12					8.12818e-05	8.65685e-05	1	1	0
TPTE	7179	broad.mit.edu	37	21	10906991	10906991	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr21:10906991G>A	ENST00000298232.7	-	23	1883	c.1516C>T	c.(1516-1518)Cgg>Tgg	p.R506W	TPTE_ENST00000342420.5_Missense_Mutation_p.R486W|TPTE_ENST00000361285.4_Missense_Mutation_p.R524W|TPTE_ENST00000415664.2_5'UTR	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	524	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAAATTCTCCGTGCTTTTTGT	0.353000													5	60					0	0	1	0	0
SMTN	6525	broad.mit.edu	37	22	31484887	31484887	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr22:31484887G>T	ENST00000333137.7	+	6	621	c.403G>T	c.(403-405)Ggg>Tgg	p.G135W	SMTN_ENST00000358743.1_Missense_Mutation_p.G135W|SMTN_ENST00000347557.2_Missense_Mutation_p.G135W	NM_001207018.1|NM_134269.2	NP_001193947.1|NP_599031.1	P53814	SMTN_HUMAN	smoothelin	135					muscle organ development|smooth muscle contraction	actin cytoskeleton|cytoplasm	actin binding|structural constituent of muscle			breast(2)|endometrium(2)|large_intestine(5)|lung(9)|ovary(3)|pancreas(1)|prostate(3)	25						GTTGTACAGCGGGCGTCCCAA	0.627000											OREG0026472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	64					4.31634e-10	5.23556e-10	1	1	0
FIGNL1	63979	broad.mit.edu	37	7	50514477	50514477	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:50514477C>A	ENST00000419119.1	-	2	2062	c.509G>T	c.(508-510)cGa>cTa	p.R170L	FIGNL1_ENST00000433017.1_Missense_Mutation_p.R170L|FIGNL1_ENST00000356889.4_Missense_Mutation_p.R170L|FIGNL1_ENST00000395556.2_Missense_Mutation_p.R170L			Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	170					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	29	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				GGTCCGGTCTCGATCATGAGC	0.463000													30	158					7.11191e-15	9.70479e-15	1	1	0
NDST3	9348	broad.mit.edu	37	4	119163220	119163220	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:119163220T>A	ENST00000296499.5	+	12	2718	c.2315T>A	c.(2314-2316)cTa>cAa	p.L772Q		NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	772	Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						GGGCAACAACTAAGAACTGAT	0.299000													33	94					0	0	1	0	0
DARC	2532	broad.mit.edu	37	1	159175656	159175656	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:159175656C>A	ENST00000537147.1	+	3	1270	c.427C>A	c.(427-429)Cag>Aag	p.Q143K	DARC_ENST00000368122.2_Missense_Mutation_p.Q143K|DARC_ENST00000368121.2_Missense_Mutation_p.Q145K			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	143					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					AGCCTTTGCCCAGGCTTTGCT	0.637000													13	16					2.23348e-06	2.45871e-06	1	1	0
ACSM2A	123876	broad.mit.edu	37	16	20477003	20477003	+	Silent	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr16:20477003C>A	ENST00000573854.1	+	3	456	c.342C>A	c.(340-342)ccC>ccA	p.P114P	ACSM2A_ENST00000219054.6_Silent_p.P114P|ACSM2A_ENST00000575690.1_Silent_p.P114P|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000424070.1_Silent_p.P114P|ACSM2A_ENST00000417235.2_Silent_p.P35P|ACSM2A_ENST00000396104.2_Silent_p.P114P	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	114					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						TGGTGCTGCCCCGAGTGCCTG	0.567000													19	54					7.26314e-15	9.70889e-15	1	1	0
BVES	11149	broad.mit.edu	37	6	105572484	105572484	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr6:105572484A>G	ENST00000314641.5	-	5	802	c.586T>C	c.(586-588)Tgt>Cgt	p.C196R	BVES_ENST00000446408.2_Missense_Mutation_p.C196R|BVES_ENST00000336775.5_Missense_Mutation_p.C196R	NM_001199563.1	NP_001186492.1	Q8NE79	POPD1_HUMAN	blood vessel epicardial substance	196					epithelial cell-cell adhesion|muscle organ development|positive regulation of locomotion|positive regulation of receptor recycling|regulation of Cdc42 GTPase activity|regulation of cell shape|regulation of Rac GTPase activity|substrate adhesion-dependent cell spreading|vesicle-mediated transport	integral to membrane|lateral plasma membrane|tight junction	structural molecule activity			NS(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|urinary_tract(1)	21		all_cancers(87;2.83e-05)|Acute lymphoblastic leukemia(125;1.95e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0101)|Colorectal(196;0.204)|Lung NSC(302;0.238)				ATAAAGGCACAGGGGTAAATG	0.323000													3	131					0	0	1	0	0
ZNF627	199692	broad.mit.edu	37	19	11728444	11728444	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr19:11728444A>G	ENST00000361113.5	+	4	1334	c.1126A>G	c.(1126-1128)Agt>Ggt	p.S376G	ZNF627_ENST00000588174.1_3'UTR	NM_145295.3	NP_660338.1	Q7L945	ZN627_HUMAN	zinc finger protein 627	376					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14						CAGTTGTTCCAGTTCGTTTCG	0.423000													3	65					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50161557	50161557	+	Silent	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr19:50161557C>T	ENST00000360565.3	+	11	3964	c.3840C>T	c.(3838-3840)caC>caT	p.H1280H		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1280	Necessary for interaction with the CTD domain of POLR2A.				mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TCCGCAAGCACGGTCGCAAGC	0.692000													8	14					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238267212	238267212	+	Silent	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:238267212A>G	ENST00000295550.4	-	21	6875	c.6423T>C	c.(6421-6423)ccT>ccC	p.P2141P	COL6A3_ENST00000409809.1_Silent_p.P1935P|COL6A3_ENST00000472056.1_Silent_p.P1534P|COL6A3_ENST00000353578.4_Silent_p.P1935P|COL6A3_ENST00000347401.3_Silent_p.P1940P|COL6A3_ENST00000346358.4_Silent_p.P1941P	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	2141	Collagen-like 2.|Triple-helical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCTCTCCTCGAGGTCCTTTAT	0.413000													22	78					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	20869200	20869200	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:20869200G>T	ENST00000298925.5	+	5	644	c.491G>T	c.(490-492)aGg>aTg	p.R164M	NELL1_ENST00000325319.5_Intron|NELL1_ENST00000532434.1_Missense_Mutation_p.R136M|NELL1_ENST00000357134.5_Missense_Mutation_p.R136M			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	136	TSP N-terminal.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						GGGAAGCCAAGGACAGAGGCA	0.478000													14	42					4.14922e-12	5.27716e-12	1	1	0
UBBP4	23666	broad.mit.edu	37	17	21731270	21731270	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr17:21731270T>C	ENST00000584755.1	+	2	969	c.572T>C	c.(571-573)aTc>aCc	p.I191T	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Intron														p.I191T(3)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						ATCCCCCCGATCAGCAGAGGC	0.547000													3	107					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332492	22332492	+	RNA	SNP	A	A	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:22332492A>C	ENST00000558896.1	+	0	299																											TATTTCTCTTATTACTATTTT	0.383000													4	239					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78413037	78413037	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:78413037A>T	ENST00000278550.7	-	28	5083	c.4621T>A	c.(4621-4623)Tcc>Acc	p.S1541T		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		ACAGCCAAGGAAGATGGGGTA	0.498000													12	24					0	0	1	0	0
OR51I2	390064	broad.mit.edu	37	11	5475045	5475045	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:5475045G>T	ENST00000341449.2	+	1	408	c.327G>T	c.(325-327)atG>atT	p.M109I	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTTCTCCATGATGGAATCAG	0.483000													36	90					8.73648e-17	1.21753e-16	1	1	0
SSX2IP	117178	broad.mit.edu	37	1	85127998	85127998	+	Silent	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:85127998G>A	ENST00000437941.2	-	7	1081	c.729C>T	c.(727-729)atC>atT	p.I243I	SSX2IP_ENST00000342203.3_Silent_p.I270I|SSX2IP_ENST00000603677.1_Intron|SSX2IP_ENST00000605755.1_Silent_p.I243I|SSX2IP_ENST00000370612.4_Silent_p.I270I	NM_001166295.1|NM_001166417.1	NP_001159767.1|NP_001159889.1	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting protein	270					cell adhesion	nucleus|protein complex				endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|urinary_tract(1)	19				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTTCCATTAGGATTTGTTTCT	0.323000													14	31					0	0	1	0	0
TUB	7275	broad.mit.edu	37	11	8111703	8111703	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:8111703C>T	ENST00000305253.4	+	4	584	c.343C>T	c.(343-345)Cgg>Tgg	p.R115W	TUB_ENST00000534099.1_Missense_Mutation_p.R66W|TUB_ENST00000299506.2_Missense_Mutation_p.R60W	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	60					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		ccggagccggcgggcccggcA	0.652000													20	41					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233190139	233190139	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:233190139C>A	ENST00000258229.8	-	25	4460	c.4226G>T	c.(4225-4227)cGt>cTt	p.R1409L	PCNXL2_ENST00000344698.2_Missense_Mutation_p.R61L	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1409						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GTTGCCCCAACGTCCAAGAAC	0.438000													5	35					1.23904e-05	1.34144e-05	1	1	0
FUT8	2530	broad.mit.edu	37	14	66096228	66096228	+	Silent	SNP	A	A	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr14:66096228A>T	ENST00000360689.5	+	6	2228	c.501A>T	c.(499-501)ctA>ctT	p.L167L	FUT8_ENST00000557164.1_Silent_p.L4L|FUT8_ENST00000358307.2_Silent_p.L38L|FUT8_ENST00000394585.1_Silent_p.L167L|FUT8_ENST00000394586.2_Silent_p.L167L	NM_004480.4|NM_178155.2	NP_004471.4|NP_835368.1	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 (alpha (1,6) fucosyltransferase)	167					in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)	22				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TGACGGATCTATACTACCTCA	0.418000													55	108					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034668	52034668	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr19:52034668G>A	ENST00000346477.3	-	2	241	c.173C>T	c.(172-174)cCa>cTa	p.P58L	SIGLEC6_ENST00000436458.1_Intron|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.P58L|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.P58L|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.P58L|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.P58L	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	58	Ig-like V-type.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GTACGAGGCTGGAAGGGTAGT	0.607000													13	74					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9054287	9054287	+	Silent	SNP	A	A	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr5:9054287A>T	ENST00000382496.5	-	19	3266	c.2601T>A	c.(2599-2601)tcT>tcA	p.S867S		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	867	TSP type-1 6.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GATTGGAGCAAGAGCGGGTCC	0.592000													14	38					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839703	15839703	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr19:15839703C>A	ENST00000305899.3	+	1	870	c.850C>A	c.(850-852)Ccc>Acc	p.P284T		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					AGTCCTCACGCCCTTCCTCAG	0.552000													41	54					1.42923e-14	1.8912e-14	1	1	0
CDX4	1046	broad.mit.edu	37	X	72667109	72667109	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:72667109T>C	ENST00000373514.2	+	1	20	c.20T>C	c.(19-21)tTg>tCg	p.L7S		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	7						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					AGCTGTCTTTTGGAGAAAGAA	0.602000													23	9					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13917345	13917345	+	Silent	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr5:13917345A>G	ENST00000265104.4	-	8	1100	c.996T>C	c.(994-996)atT>atC	p.I332I		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	332	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					CAGTGATTCGAATATCCATCT	0.383000									Kartagener syndrome				19	54					0	0	1	0	0
TRA2B	6434	broad.mit.edu	37	3	185639873	185639873	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:185639873C>G	ENST00000453386.2	-	5	839	c.564G>C	c.(562-564)agG>agC	p.R188S	TRA2B_ENST00000382191.4_Missense_Mutation_p.R88S	NM_004593.2	NP_004584.1	P62995	TRA2B_HUMAN	transformer 2 beta homolog (Drosophila)	188	RRM.				nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|protein binding|RNA binding			breast(2)|kidney(1)|large_intestine(6)|lung(4)|ovary(3)|prostate(1)|urinary_tract(1)	18						CAACTCTGATCCTACGCCCAT	0.368000													5	43					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													6	77					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12342797	12342797	+	Silent	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:12342797A>G	ENST00000358136.3	+	21	4768	c.4638A>G	c.(4636-4638)ttA>ttG	p.L1546L	VPS13D_ENST00000356315.4_Silent_p.L1546L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1546					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AGCAGGTTTTACAAACCCTGG	0.423000													16	95					0	0	1	0	0
TTI1	9675	broad.mit.edu	37	20	36640436	36640436	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr20:36640436T>C	ENST00000373448.2	-	3	2021	c.1783A>G	c.(1783-1785)Atc>Gtc	p.I595V	TTI1_ENST00000449821.1_Missense_Mutation_p.I595V|TTI1_ENST00000487362.1_5'UTR|TTI1_ENST00000373447.3_Missense_Mutation_p.I595V	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	595							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						CCAGACGTGATGGCTTGGAGG	0.448000													51	99					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36018407	36018407	+	Silent	SNP	T	T	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr19:36018407T>C	ENST00000452271.2	-	1	805	c.777A>G	c.(775-777)agA>agG	p.R259R	SBSN_ENST00000518157.1_Intron	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	132						extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CCTGGCCAAATCTCCCTGCCT	0.627000													3	5					0	0	1	0	0
SULF2	55959	broad.mit.edu	37	20	46365592	46365592	+	Silent	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr20:46365592G>A	ENST00000359930.4	-	3	1121	c.270C>T	c.(268-270)ccC>ccT	p.P90P	SULF2_ENST00000478766.1_5'UTR|SULF2_ENST00000361612.4_Silent_p.P90P|SULF2_ENST00000467815.1_Silent_p.P90P|SULF2_ENST00000484875.1_Silent_p.P90P	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	90					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						AGGAGCGTGAGGGGCAGCACA	0.592000													35	62					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2191025	2191025	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr11:2191025G>T	ENST00000381178.1	-	3	278	c.260C>A	c.(259-261)gCg>gAg	p.A87E	TH_ENST00000381175.1_Missense_Mutation_p.A83E|TH_ENST00000352909.3_Missense_Mutation_p.A56E|TH_ENST00000333684.5_Missense_Mutation_p.A60E	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	87	Poly-Ala.				dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	TGCAGCGGCCGCTGCTGCCAC	0.701000													6	8					0.0215528	0.0218869	1	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553994	140553994	+	Silent	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr5:140553994G>T	ENST00000231137.3	+	1	1752	c.1578G>T	c.(1576-1578)gcG>gcT	p.A526A		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		526	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A526A(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGCAGGCGTTCGAGTTCC	0.706000													4	111					0.000602214	0.000626112	1	1	0
ANK1	286	broad.mit.edu	37	8	41553939	41553939	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr8:41553939C>A	ENST00000396942.1	-	26	2985	c.2902G>T	c.(2902-2904)Gag>Tag	p.E968*	ANK1_ENST00000265709.8_Nonsense_Mutation_p.E1009*|ANK1_ENST00000347528.4_Nonsense_Mutation_p.E968*|ANK1_ENST00000396945.1_Nonsense_Mutation_p.E968*|ANK1_ENST00000289734.7_Nonsense_Mutation_p.E968*|ANK1_ENST00000352337.4_Nonsense_Mutation_p.E968*|ANK1_ENST00000379758.2_Nonsense_Mutation_p.E968*			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	968	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AGGCCCTCCTCCTCGGCCAGT	0.706000													15	72					8.10497e-08	9.31361e-08	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25463652	25463652	+	RNA	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:25463652C>A	ENST00000424208.1	+	0	2935				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						GCTCAGCCATCGGTGCGCTGA	0.592000													16	16					1.3612e-06	1.51117e-06	1	1	0
HCFC2	29915	broad.mit.edu	37	12	104496780	104496780	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr12:104496780C>T	ENST00000229330.4	+	15	2212	c.2108C>T	c.(2107-2109)cCt>cTt	p.P703L	HCFC2_ENST00000550335.1_3'UTR	NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	703	Fibronectin type-III 3.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						CCAACCTCACCTTCTGGAAAT	0.418000													16	33					0	0	1	0	0
TTK	7272	broad.mit.edu	37	6	80744811	80744811	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr6:80744811T>G	ENST00000509894.1	+	15	2550	c.1721T>G	c.(1720-1722)tTg>tGg	p.L574W	TTK_ENST00000369798.2_Missense_Mutation_p.L575W|TTK_ENST00000230510.3_Missense_Mutation_p.L574W			P33981	TTK_HUMAN	TTK protein kinase	575	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		ATAGCTTATTTGAATAAACTA	0.279000													32	60					0	0	1	0	0
SLC51B	123264	broad.mit.edu	37	15	65345484	65345484	+	Silent	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:65345484A>G	ENST00000334287.2	+	4	690	c.369A>G	c.(367-369)gtA>gtG	p.V123V		NM_178859.3	NP_849190.2			solute carrier family 51, beta subunit																		TTCCGGATGTACCAGAAACTG	0.478000													3	92					0	0	1	0	0
FYN	2534	broad.mit.edu	37	6	112015907	112015907	+	Splice_Site	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr6:112015907C>A	ENST00000354650.3	-	11	1649	c.1042_splice	c.e11-1	p.G348_splice	FYN_ENST00000368667.2_Splice_Site_p.G348_splice|FYN_ENST00000229470.5_Splice_Site_p.G296_splice|FYN_ENST00000368678.4_Splice_Site_p.G345_splice|FYN_ENST00000538466.1_Splice_Site_p.G345_splice|FYN_ENST00000356013.2_Splice_Site_p.G293_splice|FYN_ENST00000229471.4_Splice_Site_p.G293_splice|FYN_ENST00000368682.3_Splice_Site_p.G345_splice	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	348	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	CAGTAAACTTCCTATGAACAA	0.348000													14	60					4.3838e-07	4.95067e-07	1	1	0
ZNF92	168374	broad.mit.edu	37	7	64863891	64863891	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:64863891A>T	ENST00000328747.7	+	4	1063	c.864A>T	c.(862-864)gaA>gaT	p.E288D	ZNF92_ENST00000357512.2_Missense_Mutation_p.E256D|ZNF92_ENST00000450302.2_Missense_Mutation_p.E219D|ZNF92_ENST00000431504.1_Missense_Mutation_p.E212D	NM_152626.2	NP_689839.1	Q03936	ZNF92_HUMAN	zinc finger protein 92	288						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				ACAAATGTGAAGAATGTGGCA	0.368000													19	45					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	29					8.12818e-05	8.65685e-05	1	1	0
OR2L13	284521	broad.mit.edu	37	1	248263325	248263325	+	Silent	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:248263325C>A	ENST00000366478.2	+	3	985	c.648C>A	c.(646-648)tcC>tcA	p.S216S	OR2L13_ENST00000358120.2_Silent_p.S216S	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	216					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TCACTTCTTCCTGTGGCCGAG	0.408000													11	31					7.03913e-09	8.38296e-09	1	1	0
TRBJ2-6	28623	broad.mit.edu	37	7	142494949	142494949	+	RNA	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:142494949G>T	ENST00000390418.1	+	0	27																											CTGACTTTCGGGGCCGGCAGC	0.736000													19	65					5.45024e-15	7.51559e-15	1	1	0
FZD9	8326	broad.mit.edu	37	7	72849818	72849818	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:72849818G>A	ENST00000344575.3	+	1	1710	c.1481G>A	c.(1480-1482)cGg>cAg	p.R494Q		NM_003508.2	NP_003499.1	O00144	FZD9_HUMAN	frizzled family receptor 9	494					B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(4)|prostate(2)|skin(1)	14		Lung NSC(55;0.0659)|all_lung(88;0.152)				CCCGGAGGCCGGAGGGACTGC	0.647000													8	38					0	0	1	0	0
FRMD4B	23150	broad.mit.edu	37	3	69230382	69230382	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:69230382C>A	ENST00000542259.1	-	22	2808	c.2357G>T	c.(2356-2358)cGg>cTg	p.R786L	FRMD4B_ENST00000478263.1_Missense_Mutation_p.R492L|FRMD4B_ENST00000398540.3_Missense_Mutation_p.R840L			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	840						cytoplasm|cytoskeleton	binding	p.S784fs*53(1)		NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		GGCTGAGGACCGGTAGGAAGG	0.512000													27	35					7.26314e-15	9.70889e-15	1	1	0
CYP4A11	1579	broad.mit.edu	37	1	47400213	47400213	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:47400213C>T	ENST00000310638.4	-	7	840	c.809G>A	c.(808-810)aGg>aAg	p.R270K	CYP4A11_ENST00000457840.2_Silent_p.E114E|CYP4A11_ENST00000371905.1_Missense_Mutation_p.R270K|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000371904.4_Missense_Mutation_p.R271K	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	270					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	TTGAGCCTTCCTCAGTTGGAT	0.532000													23	88					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146351107	146351107	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr6:146351107A>T	ENST00000392299.2	+	2	924	c.454A>T	c.(454-456)Act>Tct	p.T152S	GRM1_ENST00000507907.1_Missense_Mutation_p.T152S|GRM1_ENST00000492807.2_Missense_Mutation_p.T152S|GRM1_ENST00000355289.4_Missense_Mutation_p.T152S|GRM1_ENST00000361719.2_Missense_Mutation_p.T152S|GRM1_ENST00000282753.1_Missense_Mutation_p.T152S			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	152					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCAGGCAGGACTAAGAAGCC	0.562000													30	63					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149512387	149512387	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr5:149512387G>C	ENST00000261799.4	-	7	1522	c.1053C>G	c.(1051-1053)ttC>ttG	p.F351L		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	351	Ig-like C2-type 4.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GGTTGTCTTTGAACCACAGGA	0.627000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								8	12					0	0	1	0	0
MIR573	693158	broad.mit.edu	37	4	24521863	24521863	+	RNA	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:24521863C>G	ENST00000384964.1	-	0	50					NR_030299.1																						CCAAAGACGACATGAGTAGAT	0.378000													79	173					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84642105	84642105	+	Silent	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:84642105G>T	ENST00000284136.6	-	15	1804	c.1761C>A	c.(1759-1761)atC>atA	p.I587I	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	587					cell differentiation|nervous system development	extracellular region|membrane	receptor activity	p.I587I(1)		NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TACTGTCTTCGATGTCCCAGC	0.383000													20	61					2.79863e-10	3.42636e-10	1	1	0
CAV3	859	broad.mit.edu	37	3	8775658	8775658	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:8775658T>G	ENST00000343849.2	+	1	173	c.96T>G	c.(94-96)atT>atG	p.I32M	SSUH2_ENST00000478513.1_Intron|CAV3_ENST00000472766.1_3'UTR|CAV3_ENST00000397368.2_Missense_Mutation_p.I32M	NM_001234.4|NM_033337.2	NP_001225.1|NP_203123.1	P56539	CAV3_HUMAN	caveolin 3	32					cell growth|elevation of cytosolic calcium ion concentration|muscle organ development|negative regulation of cardiac muscle hypertrophy|negative regulation of cell size|negative regulation of MAP kinase activity|negative regulation of sarcomere organization|positive regulation of microtubule polymerization|regulation of skeletal muscle contraction|regulation of ventricular cardiomyocyte membrane repolarization|T-tubule organization	caveola|dystrophin-associated glycoprotein complex|Golgi membrane|neuromuscular junction|T-tubule	protein C-terminus binding|protein complex binding|protein complex scaffold|sodium channel regulator activity			breast(1)|kidney(2)|large_intestine(4)|lung(3)|prostate(1)	11						CCAAGAACATTAACGAGGACA	0.577000													11	36					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65184456	65184456	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr17:65184456T>A	ENST00000358691.5	-	12	1307	c.1141A>T	c.(1141-1143)Att>Ttt	p.I381F	HELZ_ENST00000580168.1_Missense_Mutation_p.I381F	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					GCTGCATCAATCATTACTCTT	0.353000													40	80					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96124010	96124010	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr4:96124010C>A	ENST00000453304.1	-	12	2356	c.2008G>T	c.(2008-2010)Gta>Tta	p.V670L		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	670					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GAATGTCCTACCAGGGCGTAG	0.602000													33	102					3.09479e-21	4.45513e-21	1	1	0
CAND2	23066	broad.mit.edu	37	3	12856687	12856687	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:12856687C>G	ENST00000456430.2	+	8	1095	c.1054C>G	c.(1054-1056)Cgc>Ggc	p.R352G	CAND2_ENST00000295989.5_Missense_Mutation_p.R259G	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	352					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CTGGAAGGTGCGCCGGGCAGC	0.607000													33	65					0	0	1	0	0
FAP	2191	broad.mit.edu	37	2	163031437	163031437	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:163031437C>A	ENST00000188790.4	-	22	2116	c.1909G>T	c.(1909-1911)Gga>Tga	p.G637*	FAP_ENST00000443424.1_Nonsense_Mutation_p.G612*	NM_004460.2	NP_004451.2	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha	637					endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(34)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)	63						AGACCAGTTCCAGATGCAAGG	0.403000													31	52					2.38262e-10	2.94456e-10	1	1	0
KRTAP24-1	643803	broad.mit.edu	37	21	31655019	31655019	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr21:31655019G>T	ENST00000340345.4	-	1	257	c.232C>A	c.(232-234)Ccc>Acc	p.P78T		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	78						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						CAGGTCTTGGGCTCACAGCTG	0.527000													13	53					7.93312e-07	8.88238e-07	1	1	0
RNF213	57674	broad.mit.edu	37	17	78318846	78318846	+	Silent	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr17:78318846G>T	ENST00000582970.1	+	29	6854	c.6711G>T	c.(6709-6711)ccG>ccT	p.P2237P	RNF213_ENST00000508628.2_Silent_p.P2286P|RNF213_ENST00000336301.6_Silent_p.P310P	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TCTGCAATCCGAGTTTTATTG	0.488000													31	114					4.16155e-14	5.45162e-14	1	1	0
PRUNE2	158471	broad.mit.edu	37	9	79323199	79323199	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr9:79323199G>T	ENST00000428286.1	-	8	4114	c.2914C>A	c.(2914-2916)Cag>Aag	p.Q972K	PRUNE2_ENST00000376718.3_Missense_Mutation_p.Q1331K			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1331					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTGGCTCCCTGGGCTTCCTTC	0.532000													16	10					1.67942e-08	1.98201e-08	1	1	0
HUWE1	10075	broad.mit.edu	37	X	53566629	53566629	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:53566629T>A	ENST00000342160.3	-	74	12078	c.11621A>T	c.(11620-11622)cAt>cTt	p.H3874L	HUWE1_ENST00000262854.6_Missense_Mutation_p.H3874L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3874					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TAGCACCGCATGCTGGTCATG	0.562000													23	20					0	0	1	0	0
HNRNPH2	3188	broad.mit.edu	37	X	100667241	100667241	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:100667241A>G	ENST00000316594.5	+	2	343	c.265A>G	c.(265-267)Aac>Gac	p.N89D		NM_001032393.2|NM_001199973.1|NM_001199974.1|NM_019597.4	NP_001027565.1|NP_001186902.1|NP_001186903.1|NP_062543.1	P55795	HNRH2_HUMAN	heterogeneous nuclear ribonucleoprotein H2 (H')	89	RRM 1.				nuclear mRNA splicing, via spliceosome	actin cytoskeleton|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			breast(3)|large_intestine(2)|lung(6)|skin(1)	12						ATTCAAGTCTAACAGTGTTGA	0.448000													60	39					0	0	1	0	0
SNRPN	6638	broad.mit.edu	37	15	25221490	25221490	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:25221490G>T	ENST00000444203.2	+	4	1245	c.206G>T	c.(205-207)cGg>cTg	p.R69L	SNRPN_ENST00000577565.1_Missense_Mutation_p.R65L|SNRPN_ENST00000400098.1_Missense_Mutation_p.R65L|SNRPN_ENST00000390687.4_Missense_Mutation_p.R65L|SNRPN_ENST00000346403.6_Missense_Mutation_p.R65L|SNRPN_ENST00000400100.1_Missense_Mutation_p.R65L|SNURF_ENST00000338094.6_3'UTR|SNRPN_ENST00000400097.1_Missense_Mutation_p.R65L|SNRPN_ENST00000554227.2_Missense_Mutation_p.R69L			P63162	RSMN_HUMAN	small nuclear ribonucleoprotein polypeptide N	65					RNA splicing	small nuclear ribonucleoprotein complex|spliceosomal complex	identical protein binding|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(2)	24		all_cancers(20;9.33e-22)|Breast(32;0.000625)		all cancers(64;3.38e-08)|Epithelial(43;3.45e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000207)|GBM - Glioblastoma multiforme(186;0.125)		GAAGAAAAGCGGGTTTTGGGT	0.448000									Prader-Willi syndrome				19	74					4.72057e-08	5.47252e-08	1	1	0
CGREF1	10669	broad.mit.edu	37	2	27324379	27324379	+	Silent	SNP	C	C	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:27324379C>T	ENST00000402394.1	-	6	988	c.720G>A	c.(718-720)ggG>ggA	p.G240G	CGREF1_ENST00000312734.4_Silent_p.G240G|CGREF1_ENST00000402550.1_Intron|CGREF1_ENST00000404694.3_Silent_p.G362G|CGREF1_ENST00000452318.2_Intron|CGREF1_ENST00000260595.5_Silent_p.G240G|CGREF1_ENST00000405600.1_Silent_p.G240G	NM_006569.5	NP_006560.3	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	240					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCCAGCTTCCCCTCTGGGCC	0.697000													75	209					0	0	1	0	0
KLHL18	23276	broad.mit.edu	37	3	47385400	47385400	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:47385400G>T	ENST00000232766.5	+	10	1714	c.1694G>T	c.(1693-1695)gGt>gTt	p.G565V	KLHL18_ENST00000455924.2_Missense_Mutation_p.G453V	NM_025010.4	NP_079286.2	O94889	KLH18_HUMAN	kelch-like family member 18	565										endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	21		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		GGAGGGGTCGGTGTGGGCTGC	0.577000													49	113					7.10663e-31	1.03441e-30	1	1	0
NDUFAF1	51103	broad.mit.edu	37	15	41689208	41689208	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr15:41689208A>C	ENST00000260361.4	-	2	431	c.50T>G	c.(49-51)tTc>tGc	p.F17C		NM_016013.3	NP_057097.2	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 1	17					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	12		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		TGGCTTAGAGAATTTTCTGAG	0.433000													24	22					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127881	152127884	+	Frame_Shift_Del	DEL	TGTC	TGTC	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr1:152127881_152127884delTGTC	ENST00000316073.3	-	3	1755_1758	c.1691_1694delGACA	c.(1690-1695)aafs	p.RQ564fs		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	564	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						GCTCTGGCCTTGTCTGTCTGTCTG	0.485													9	1160	---	---	---	---					
RP11-13J8.1	0	broad.mit.edu	37	2	201967218	201967218	+	RNA	DEL	G	G	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:201967218delG	ENST00000448256.1	+	0	628																											aaaaaaaaaagaaTTTGTTCT	0.463													2	4	---	---	---	---					
STK16	8576	broad.mit.edu	37	2	220112939	220112941	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr2:220112939_220112941delATG	ENST00000409638.3	+	7	854_856	c.682_684delATG	c.(682-684)del	p.M229del	STK16_ENST00000409260.1_In_Frame_Del_p.M274del|STK16_ENST00000409743.1_In_Frame_Del_p.M197del|STK16_ENST00000409516.3_In_Frame_Del_p.M111del|STK16_ENST00000396738.2_In_Frame_Del_p.M229del	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	229	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTATATGCCATGATGTTTGGGG	0.517													32	95	---	---	---	---					
UBE2E1-AS1	100874092	broad.mit.edu	37	3	23847374	23847376	+	RNA	DEL	GAG	GAG	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr3:23847374_23847376delGAG	ENST00000426702.1	-	0	87																											gggtgagggcgaggaggaggagg	0.690													3	6	---	---	---	---					
DEK	7913	broad.mit.edu	37	6	18264071	18264072	+	Splice_Site	DEL	CA	CA	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr6:18264071_18264072delCA	ENST00000397239.3	-	2	593		c.e2+1		DEK_ENST00000244776.7_Splice_Site	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene						chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			CGACTCCCCCCACCTTTTtcct	0.520			T	NUP214	AML								12	57	---	---	---	---					
FAM126A	84668	broad.mit.edu	37	7	23015874	23015874	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:23015874delT	ENST00000432176.2	-	7	813	c.581delA	c.(580-582)tcfs	p.Y194fs	FAM126A_ENST00000409923.1_Frame_Shift_Del_p.Y194fs	NM_032581.3	NP_115970.2	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	194				Y -> C (in Ref. 1; BAB39849).		cytoplasm|membrane	signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|urinary_tract(2)	23						ACTGGGCATGTAAGTTAAGGC	0.303													59	149	---	---	---	---					
TRBV6-8	28599	broad.mit.edu	37	7	142124496	142124497	+	RNA	INS	-	-	G	rs72463875		TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr7:142124496_142124497insG	ENST00000390376.2	-	0	49																											AATCCACGCAAGGGCCCTGCCC	0.614													9	161	---	---	---	---					
KIF3B	9371	broad.mit.edu	37	20	30898763	30898765	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr20:30898763_30898765delGAG	ENST00000375712.3	+	2	1350_1352	c.1183_1185delGAG	c.(1183-1185)del	p.E399del	KIF3B_ENST00000418717.2_Intron	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	399	Poly-Glu.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGGTGGggaagaggaggaggagg	0.571													7	51	---	---	---	---					
LTN1	26046	broad.mit.edu	37	21	30329201	30329201	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chr21:30329201delC	ENST00000361371.4	-	16	3112	c.2962delG	c.(2962-2964)aafs	p.E988fs	LTN1_ENST00000389194.2_Frame_Shift_Del_p.E1034fs	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	988							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						ATGTCCTGTTCCTTAAAATCT	0.323													9	27	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149984524	149984526	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-55-8090-01A-11D-2238-08	TCGA-55-8090-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e3b5f1b6-b226-4d2c-84be-d8911f6bba62	d9cc8f37-db50-498a-9ec9-5ba1761befd6	g.chrX:149984524_149984526delGTG	ENST00000370377.3	-	3	273_275	c.156_158delCAC	c.(154-159)aca>ac	p.TT52del	CD99L2_ENST00000437787.2_In_Frame_Del_p.TT52del|CD99L2_ENST00000346693.4_5'UTR|CD99L2_ENST00000466436.1_Intron|CD99L2_ENST00000355149.3_Intron	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	52	Poly-Thr.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552													8	380	---	---	---	---