Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRPM1	4308	broad.mit.edu	37	15	31294278	31294278	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr15:31294278C>T	ENST00000542188.1	-	27	4989	c.4676G>A	c.(4675-4677)cGc>cAc	p.R1559H	RP11-348B17.1_ENST00000561299.1_RNA|TRPM1_ENST00000397795.2_Missense_Mutation_p.R1520H|TRPM1_ENST00000256552.6_Missense_Mutation_p.R1542H	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	1520					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		TAGGGACAAGCGAGGGATTCG	0.443000													123	164					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28210813	28210813	+	Silent	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr8:28210813G>A	ENST00000344423.5	-	5	827	c.696C>T	c.(694-696)ccC>ccT	p.P232P	ZNF395_ENST00000523202.1_Silent_p.P232P|ZNF395_ENST00000523095.1_Silent_p.P232P	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	232					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGGGGTGGGGGGGCGAGGGGG	0.617000													3	41					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45004684	45004684	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr7:45004684G>A	ENST00000258787.7	-	18	2522	c.2386C>T	c.(2386-2388)Cgg>Tgg	p.R796W		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	796						myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						TGCCGGGCCCGCCACCTGGGA	0.637000													61	60					0	0	1	0	0
KCNH8	131096	broad.mit.edu	37	3	19554592	19554592	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr3:19554592C>T	ENST00000328405.2	+	13	2476	c.2210C>T	c.(2209-2211)tCg>tTg	p.S737L		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	737						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						GGATCTTCTTCGCGCAACAAG	0.547000													14	43					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111694646	111694646	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr6:111694646T>C	ENST00000435970.1	-	15	5494	c.4678A>G	c.(4678-4680)Agt>Ggt	p.S1560G	REV3L_ENST00000368802.3_Missense_Mutation_p.S1638G|REV3L_ENST00000358835.3_Missense_Mutation_p.S1638G|REV3L_ENST00000368805.1_Missense_Mutation_p.S1638G			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1638					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GGAGATAAACTATCTTCAAGT	0.338000								DNA polymerases (catalytic subunits)					10	16					0	0	1	0	0
KLHDC2	23588	broad.mit.edu	37	14	50241313	50241313	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr14:50241313T>C	ENST00000298307.5	+	3	1129	c.268T>C	c.(268-270)Tct>Cct	p.S90P	KLHDC2_ENST00000553538.1_3'UTR|KLHDC2_ENST00000557247.1_Missense_Mutation_p.S90P|KLHDC2_ENST00000554589.1_Missense_Mutation_p.S90P	NM_014315.2	NP_055130.1	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	90						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(31;0.000959)|Breast(41;0.0117)					TGTTCCTCCTTCTATGTCAGG	0.383000													6	238					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295989	20295989	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr14:20295989C>T	ENST00000315947.1	+	1	382	c.382C>T	c.(382-384)Cgg>Tgg	p.R128W	OR4N2_ENST00000568211.1_Missense_Mutation_p.R128W	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CGCCATCTGCCGGCCTCTGCA	0.522000													40	564					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179639038	179639038	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr2:179639038C>T	ENST00000589042.1	-	30	7177	c.6953G>A	c.(6952-6954)cGt>cAt	p.R2318H	TTN_ENST00000360870.5_Missense_Mutation_p.R2318H|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R2318H|TTN_ENST00000460472.2_Missense_Mutation_p.R2272H|TTN_ENST00000359218.5_Missense_Mutation_p.R2272H|TTN_ENST00000342992.6_Missense_Mutation_p.R2318H|TTN_ENST00000342175.6_Missense_Mutation_p.R2272H|TTN-AS1_ENST00000584485.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2033	Ig-like 12.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGACGTCCACGACGAGATGT	0.403000													37	70					0	0	1	0	0
COG1	9382	broad.mit.edu	37	17	71199844	71199844	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr17:71199844C>A	ENST00000299886.4	+	9	2374	c.2294C>A	c.(2293-2295)cCa>cAa	p.P765Q		NM_018714.2	NP_061184.1	Q8WTW3	COG1_HUMAN	component of oligomeric golgi complex 1	765					Golgi organization|intra-Golgi vesicle-mediated transport|protein transport	Golgi membrane|Golgi transport complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18			LUSC - Lung squamous cell carcinoma(166;0.197)			CATGCCTTGCCAAAGGTGACA	0.428000													3	86					1	1	1	1	0
AFF2	2334	broad.mit.edu	37	X	148037365	148037365	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chrX:148037365G>A	ENST00000370460.2	+	11	2269	c.1790G>A	c.(1789-1791)cGt>cAt	p.R597H	AFF2_ENST00000370457.5_Missense_Mutation_p.R564H|AFF2_ENST00000286437.5_Missense_Mutation_p.R238H|AFF2_ENST00000342251.3_Missense_Mutation_p.R564H	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	597					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding	p.R597H(3)|p.R238H(1)		breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GAGAAAGCCCGTCCACGGCCC	0.468000													43	37					0	0	1	0	0
PNMAL2	57469	broad.mit.edu	37	19	46998259	46998259	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr19:46998259C>T	ENST00000599531.1	-	1	1496	c.464G>A	c.(463-465)aGg>aAg	p.R155K	PNMAL2_ENST00000594749.1_Intron|AC011484.1_ENST00000377652.3_Silent_p.L124L|PNMAL2_ENST00000377655.2_Missense_Mutation_p.R155K	NM_020709.1	NP_065760.1	Q9ULN7	PNML2_HUMAN	paraneoplastic Ma antigen family-like 2	155										central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(4)	8		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CCTTGGGTTCCTGGCTGCCCC	0.667000													17	37					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91873619	91873619	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chrX:91873619G>C	ENST00000373094.1	+	7	4569	c.3724G>C	c.(3724-3726)Gcc>Ccc	p.A1242P	PCDH11X_ENST00000361655.2_Missense_Mutation_p.A1224P|PCDH11X_ENST00000373097.1_Missense_Mutation_p.A1232P|PCDH11X_ENST00000298274.8_Missense_Mutation_p.A1205P|PCDH11X_ENST00000373088.1_Missense_Mutation_p.A1205P|PCDH11X_ENST00000406881.1_Missense_Mutation_p.A1234P|PCDH11X_ENST00000504220.1_3'UTR	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1242					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						ACAGGCCTCAGCCCTCTGCTA	0.587000													3	113					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49701644	49701644	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr5:49701644A>G	ENST00000303221.5	-	5	730	c.515T>C	c.(514-516)gTa>gCa	p.V172A	EMB_ENST00000514111.1_Missense_Mutation_p.V122A|EMB_ENST00000508934.1_Missense_Mutation_p.V118A|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	172	Ig-like V-type 2.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				AGAATCCCCTACGTAAGAGAT	0.348000													13	47					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19478814	19478814	+	Missense_Mutation	SNP	T	T	C	rs147127000	byFrequency	TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:19478814T>C	ENST00000375267.2	-	47	6992	c.6989A>G	c.(6988-6990)aAc>aGc	p.N2330S	UBR4_ENST00000375254.3_Missense_Mutation_p.N2330S|UBR4_ENST00000375217.2_Missense_Mutation_p.N2330S|UBR4_ENST00000375226.2_Missense_Mutation_p.N2330S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2330					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TACCTTGGTGTTGGCCACATA	0.458000													17	371					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48573418	48573418	+	Translation_Start_Site	SNP	T	T	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr18:48573418T>A	ENST00000342988.3	+	2	540	c.2T>A	c.(1-3)aTg>aAg	p.M1K	RP11-729L2.2_ENST00000588256.1_3'UTR|RP11-729L2.2_ENST00000590722.2_3'UTR|SMAD4_ENST00000398417.2_Start_Codon_SNP_p.M1K|SMAD4_ENST00000588745.1_Start_Codon_SNP_p.M1K|SMAD4_ENST00000452201.2_Start_Codon_SNP_p.M1K	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	1					BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(5)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CTTGAACAAATGGACAATATG	0.363000													8	36					0	0	1	0	0
CSHL1	1444	broad.mit.edu	37	17	61987511	61987511	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr17:61987511G>C	ENST00000450719.3	-	3	437	c.200C>G	c.(199-201)gCa>gGa	p.A67G	CSHL1_ENST00000346606.6_Intron|CSHL1_ENST00000259003.10_Intron|CSHL1_ENST00000438387.2_Intron|CSHL1_ENST00000392824.4_3'UTR|CSHL1_ENST00000309894.5_Intron|CSHL1_ENST00000558099.1_5'UTR|CSHL1_ENST00000561003.1_Missense_Mutation_p.A78G			Q14406	CSHL_HUMAN	chorionic somatomammotropin hormone-like 1	0						extracellular region	hormone activity|metal ion binding			endometrium(3)|lung(6)	9						GACCCCTGGTGCCACCCTCAC	0.572000													4	64					0	0	1	0	0
MARS2	92935	broad.mit.edu	37	2	198571055	198571055	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr2:198571055G>A	ENST00000282276.6	+	1	969	c.926G>A	c.(925-927)gGt>gAt	p.G309D	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	309					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	CATATCATAGGTAAGGACATT	0.517000													33	97					0	0	1	0	0
SIM2	6493	broad.mit.edu	37	21	38095422	38095422	+	Silent	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr21:38095422C>T	ENST00000290399.6	+	5	1147	c.534C>T	c.(532-534)agC>agT	p.S178S	SIM2_ENST00000430056.3_Silent_p.S178S	NM_005069.3	NP_005060.1	Q14190	SIM2_HUMAN	single-minded family bHLH transcription factor 2	178					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(6)|prostate(1)|skin(2)	16						TGACCTGCAGCGGATACAAGG	0.532000													29	75					0	0	1	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946407	16946407	+	RNA	SNP	T	T	G	rs10796418	by1000genomes	TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:16946407T>G	ENST00000412962.1	-	0	1112																											AGCAATCTCCTCACTCAGCTG	0.672000													3	32					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237185	140237185	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr5:140237185G>A	ENST00000307360.5	+	1	1552	c.1552G>A	c.(1552-1554)Gcg>Acg	p.A518T	PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.A518T	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAGGTGTACGCGCTGCAGCC	0.682000													64	185					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr21:47754527A>G	ENST00000359568.5	+	3	591	c.484A>G	c.(484-486)Agt>Ggt	p.S162G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													3	138					0	0	1	0	0
SLC35F3	148641	broad.mit.edu	37	1	234367219	234367219	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:234367219G>T	ENST00000366618.3	+	3	485	c.340G>T	c.(340-342)Gtg>Ttg	p.V114L	SLC35F3_ENST00000366617.3_Missense_Mutation_p.V45L	NM_173508.2	NP_775779.1	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	45					transport	integral to membrane				breast(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|urinary_tract(1)	32	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			ACCGGCCGGGGTGGAGGCCGG	0.731000													8	23					2.61681e-11	2.94392e-11	1	1	0
NOS3	4846	broad.mit.edu	37	7	150695446	150695446	+	Splice_Site	SNP	T	T	G			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr7:150695446T>G	ENST00000297494.3	+	6	941	c.582_splice	c.e6-1	p.V195_splice	NOS3_ENST00000461406.1_5'UTR|NOS3_ENST00000484524.1_Splice_Site_p.V195_splice|NOS3_ENST00000467517.1_Splice_Site_p.V195_splice	NM_000603.4	NP_000594.2	P29474	NOS3_HUMAN	nitric oxide synthase 3 (endothelial cell)	195	Interaction with NOSIP.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(3)|breast(3)|central_nervous_system(5)|endometrium(1)|kidney(4)|large_intestine(6)|liver(2)|lung(11)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	50	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	CTGGCTCAGGTGTTCGATGCC	0.612000													6	30					0	0	1	0	0
ESM1	11082	broad.mit.edu	37	5	54281255	54281255	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr5:54281255G>T	ENST00000381405.4	-	1	236	c.91C>A	c.(91-93)Cac>Aac	p.H31N	ESM1_ENST00000598310.1_Intron|ESM1_ENST00000381403.4_Missense_Mutation_p.H31N	NM_007036.4	NP_008967.1	Q9NQ30	ESM1_HUMAN	endothelial cell-specific molecule 1	31	IGFBP N-terminal.				angiogenesis|regulation of cell growth	extracellular region	growth factor activity|insulin-like growth factor binding			breast(1)|kidney(1)|large_intestine(4)|lung(4)	10		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.116)	Lung(15;0.23)			CTGTCACAGTGTTGAGGGCAG	0.612000													5	90					0.00116845	0.00125191	1	1	0
CDC40	51362	broad.mit.edu	37	6	110501725	110501725	+	Silent	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr6:110501725C>T	ENST00000368932.1	+	2	179	c.78C>T	c.(76-78)agC>agT	p.S26S	CDC40_ENST00000368930.1_Silent_p.S26S|CDC40_ENST00000307731.1_Silent_p.S26S|CDC40_ENST00000368933.1_Silent_p.S26S			O60508	PRP17_HUMAN	cell division cycle 40	26					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		ACAGTGAGAGCAGTCGGTGTC	0.597000													19	45					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12010521	12010521	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:12010521G>A	ENST00000196061.4	+	4	437	c.410G>A	c.(409-411)aGg>aAg	p.R137K	PLOD1_ENST00000485046.1_3'UTR|PLOD1_ENST00000376369.3_Missense_Mutation_p.R184K	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	137					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCAGACCGCAGGCTGGAGACC	0.647000													5	58					0	0	1	0	0
FAM218A	152756	broad.mit.edu	37	4	165878576	165878576	+	Silent	SNP	T	T	C			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr4:165878576T>C	ENST00000513876.2	+	1	477	c.402T>C	c.(400-402)ccT>ccC	p.P134P	TRIM61_ENST00000329314.5_Intron	NM_153027.1	NP_694572.1	Q96MZ4	CD039_HUMAN	family with sequence similarity 218, member A	134																	GGTCCCAGCCTCTTTTTGTGA	0.572000													3	82					0	0	1	0	0
PPWD1	23398	broad.mit.edu	37	5	64881965	64881965	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr5:64881965C>T	ENST00000261308.5	+	10	1826	c.1754C>T	c.(1753-1755)tCa>tTa	p.S585L	PPWD1_ENST00000538977.1_Missense_Mutation_p.S429L|PPWD1_ENST00000535264.1_Missense_Mutation_p.S555L	NM_015342.3	NP_056157.1	Q96BP3	PPWD1_HUMAN	peptidylprolyl isomerase domain and WD repeat containing 1	585	PPIase cyclophilin-type.				protein folding	catalytic step 2 spliceosome	peptidyl-prolyl cis-trans isomerase activity			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	19		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		Lung(70;0.00451)		AACGCGGGATCAAATACTAAT	0.393000													14	87					0	0	1	0	0
SKOR1	390598	broad.mit.edu	37	15	68118525	68118525	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr15:68118525G>A	ENST00000380035.2	+	2	417	c.359G>A	c.(358-360)cGc>cAc	p.R120H	SKOR1_ENST00000554054.1_Missense_Mutation_p.R92H|SKOR1_ENST00000389002.1_Missense_Mutation_p.R111H|SKOR1_ENST00000341418.5_Missense_Mutation_p.R306H|SKOR1_ENST00000554240.1_Missense_Mutation_p.R81H			P84550	SKOR1_HUMAN	SKI family transcriptional corepressor 1	120					negative regulation of BMP signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|dendrite|neuronal cell body|nucleus	nucleotide binding|SMAD binding|transcription repressor activity			endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(7)|urinary_tract(1)	23						CACAACCGCCGCGTGGCCCTG	0.637000													13	51					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26692923	26692923	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr22:26692923G>A	ENST00000529632.2	+	4	1235	c.1039G>A	c.(1039-1041)Gtc>Atc	p.V347I	SEZ6L_ENST00000343706.4_Missense_Mutation_p.V347I|SEZ6L_ENST00000360929.3_Missense_Mutation_p.V347I|SEZ6L_ENST00000402979.1_Missense_Mutation_p.V120I|SEZ6L_ENST00000248933.6_Missense_Mutation_p.V347I|SEZ6L_ENST00000404234.3_Missense_Mutation_p.V347I|SEZ6L_ENST00000403121.1_Missense_Mutation_p.V120I	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	347	CUB 1.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TACCCTGACCGTCCTGGCCAA	0.617000													18	49					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	177001910	177001910	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:177001910G>A	ENST00000367654.2	-	3	560	c.547C>T	c.(547-549)Cgc>Tgc	p.R183C	ASTN1_ENST00000424564.2_Missense_Mutation_p.R183C|ASTN1_ENST00000367657.3_Missense_Mutation_p.R183C|ASTN1_ENST00000361833.2_Missense_Mutation_p.R183C|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	183					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ACCCGGCGGCGTTTGCACCAG	0.602000													11	69					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274424	39274424	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr17:39274424G>C	ENST00000391413.2	-	1	182	c.144C>G	c.(142-144)agC>agG	p.S48R		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	48	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].		Missing (in allele KAP4.14).			keratin filament		p.S48R(2)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			GCCTGCAGCAGCTGGACACAC	0.672000													6	127					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248789976	248789976	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:248789976C>T	ENST00000330803.2	-	1	515	c.454G>A	c.(454-456)Gat>Aat	p.D152N		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGAAAGCCATCGAGGGAGCCC	0.527000													12	19					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51728620	51728620	+	Missense_Mutation	SNP	C	C	T	rs138300409	byFrequency	TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr19:51728620C>T	ENST00000262262.4	+	2	205	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W	CD33_ENST00000391796.3_Missense_Mutation_p.R62W|CD33_ENST00000421133.2_Intron|CD33_ENST00000436584.2_Intron	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	62	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	TTACTGGTTCCGGGAAGGAGC	0.537000													5	128					0	0	1	0	0
E2F7	144455	broad.mit.edu	37	12	77424046	77424046	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr12:77424046G>T	ENST00000322886.7	-	10	1684	c.1449C>A	c.(1447-1449)ttC>ttA	p.F483L	E2F7_ENST00000416496.2_Missense_Mutation_p.F483L	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	483					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						AGAGGACAGGGAAAGGAGCAA	0.473000													53	185					5.00936e-31	5.78003e-31	1	1	0
FCRL3	115352	broad.mit.edu	37	1	157668197	157668197	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:157668197G>A	ENST00000368184.3	-	4	566	c.275C>T	c.(274-276)gCc>gTc	p.A92V	FCRL3_ENST00000368186.5_Missense_Mutation_p.A92V	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	92	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CACATGCACGGCATCACTGAG	0.473000													6	109					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370836	35370836	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:35370836G>A	ENST00000373347.1	-	3	417	c.149C>T	c.(148-150)cCg>cTg	p.P50L	DLGAP3_ENST00000495979.1_5'UTR|DLGAP3_ENST00000235180.4_Missense_Mutation_p.P50L			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	50					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane		p.P50L(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GCCAGCTCTCGGGGCACAGAA	0.687000													4	8					0	0	1	0	0
LPIN1	23175	broad.mit.edu	37	2	11945256	11945256	+	Silent	SNP	C	C	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr2:11945256C>A	ENST00000256720.2	+	16	2208	c.2115C>A	c.(2113-2115)atC>atA	p.I705I	LPIN1_ENST00000449576.2_Silent_p.I790I|LPIN1_ENST00000396097.1_Silent_p.I435I|LPIN1_ENST00000396099.1_Silent_p.I747I|LPIN1_ENST00000404113.2_Silent_p.I206I|LPIN1_ENST00000425416.2_Silent_p.I711I	NM_145693.2	NP_663731.1	Q14693	LPIN1_HUMAN	lipin 1	705	C-LIP.				fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(15)|liver(1)|lung(10)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	45	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		ATCAGGGCATCGCTAAGCTGT	0.468000													3	80					0.014758	0.0150934	1	1	0
PIK3C2B	5287	broad.mit.edu	37	1	204429716	204429716	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr1:204429716T>A	ENST00000367187.3	-	7	1940	c.1384A>T	c.(1384-1386)Atg>Ttg	p.M462L	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.M462L	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	462					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TTCTGCTCCATCAGCTGTAGC	0.547000													14	134					0	0	1	0	0
POU4F2	5458	broad.mit.edu	37	4	147560457	147560458	+	In_Frame_Ins	INS	-	-	GGC	rs67907220		TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr4:147560457_147560458insGGC	ENST00000281321.3	+	1	413_414	c.165_166insGGC	c.(163-168)gggcgg>ggGGCgcgg	p.55_56GR>GAR	AC093887.1_ENST00000584185.1_RNA	NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	55	Poly-Gly.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					ACGCTggtggtggcggcggcgg	0.762													2	4	---	---	---	---					
VPS37A	137492	broad.mit.edu	37	8	17104764	17104764	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr8:17104764delT	ENST00000324849.4	+	1	685	c.11delT	c.(10-12)ctfs	p.L4fs	VPS37A_ENST00000521829.1_Frame_Shift_Del_p.L4fs|VPS37A_ENST00000324815.3_Frame_Shift_Del_p.L4fs|VPS37A_ENST00000521005.1_Frame_Shift_Del_p.L4fs	NM_001145152.1|NM_152415.2	NP_001138624.1|NP_689628.2	Q8NEZ2	VP37A_HUMAN	vacuolar protein sorting 37 homolog A (S. cerevisiae)	4					cellular membrane organization|endosome transport|protein transport	centrosome|late endosome membrane|nucleus				autonomic_ganglia(1)|breast(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	10				Colorectal(111;0.0553)|COAD - Colon adenocarcinoma(73;0.212)		ATGAGCTGGCTTTTTCCCCTG	0.697													2	4	---	---	---	---					
COL22A1	169044	broad.mit.edu	37	8	139809072	139809072	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr8:139809072delT	ENST00000303045.6	-	12	2032	c.1586delA	c.(1585-1587)agfs	p.K529fs	COL22A1_ENST00000435777.1_Frame_Shift_Del_p.K529fs	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	529	Collagen-like 2.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTTTTCACCCTTTTCCCCTTG	0.463										HNSCC(7;0.00092)			7	409	---	---	---	---					
SCRIB	23513	broad.mit.edu	37	8	144896281	144896281	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr8:144896281delA	ENST00000356994.2	-	2	173	c.167delT	c.(166-168)tcfs	p.F56fs	SCRIB_ENST00000320476.3_Frame_Shift_Del_p.F56fs|SCRIB_ENST00000377533.3_5'UTR	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	56	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CAGCAGCCGGAAAAAAGGCTG	0.602													2	4	---	---	---	---					
AMBRA1	55626	broad.mit.edu	37	11	46563495	46563496	+	Splice_Site	DEL	CT	CT	-			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chr11:46563495_46563496delCT	ENST00000458649.2	-	7	2489_2490	c.2072_splice	c.e7+1	p.R692_splice	AMBRA1_ENST00000298834.3_Splice_Site_p.R692_splice|AMBRA1_ENST00000528950.1_Splice_Site_p.R691_splice|AMBRA1_ENST00000426438.1_Splice_Site_p.R691_splice|AMBRA1_ENST00000314845.3_Splice_Site_p.R602_splice|AMBRA1_ENST00000534300.1_Splice_Site_p.R692_splice|AMBRA1_ENST00000533727.1_Splice_Site_p.R601_splice			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	692					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		GACTGCTTACCTCCTGAGTGAA	0.480													8	181	---	---	---	---					
PHKA2	5256	broad.mit.edu	37	X	18947408	18947408	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8091-01A-11D-2238-08	TCGA-55-8091-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3892dc09-e9c1-4185-bf6f-f071db30fe57	f803321b-1361-451d-aba8-b60d678b225c	g.chrX:18947408delC	ENST00000379942.4	-	13	1927	c.1262delG	c.(1261-1263)gtfs	p.G421fs		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	421					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					ATCGATTTCACCAGCGGCAAG	0.323													2	4	---	---	---	---