Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TRHDE	29953	broad.mit.edu	37	12	72936070	72936070	+	Splice_Site	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:72936070G>C	ENST00000261180.4	+	7	1683		c.e7-1			NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme						cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CTTTCCTATAGGGTGCTGCTT	0.299000													12	23					0	0	0.479597	0	0
CITED2	10370	broad.mit.edu	37	6	139694818	139694818	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:139694818G>A	ENST00000367651.2	-	2	479	c.264C>T	c.(262-264)gcC>gcT	p.A88A	CITED2_ENST00000536159.1_Silent_p.A88A|CITED2_ENST00000537332.1_Silent_p.A88A	NM_006079.4	NP_006070.2	Q99967	CITE2_HUMAN	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	88					adrenal cortex formation|anti-apoptosis|cell proliferation|determination of left/right symmetry|heart development|liver development|negative regulation of cell migration|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell cycle|positive regulation of cell-cell adhesion|positive regulation of male gonad development|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of organ formation|response to estrogen stimulus|response to fluid shear stress|response to hypoxia|sex determination	cytoplasm|nuclear chromatin|nucleus	chromatin binding|LBD domain binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			large_intestine(1)|lung(4)	5	Breast(32;0.226)			GBM - Glioblastoma multiforme(68;0.000171)|OV - Ovarian serous cystadenocarcinoma(155;0.00134)		TGGCCGCGGGGGCCAGCGCGC	0.672000													14	10					0	0	0.479597	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322393	79322393	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:79322393C>T	ENST00000428286.1	-	8	4920	c.3720G>A	c.(3718-3720)gtG>gtA	p.V1240V	PRUNE2_ENST00000376718.3_Silent_p.V1599V			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1599					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTAAATCCTTCACTTTGGTAA	0.368000													6	24					0	0	0.217242	0	0
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:145302714A>G	ENST00000342960.5	+	8	1187	c.1152A>G	c.(1150-1152)ttA>ttG	p.L384L	RP11-458D21.5_ENST00000468030.1_3'UTR|NBPF10_ENST00000369338.1_Silent_p.L113L|NBPF10_ENST00000369339.2_Silent_p.L113L	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	384								p.L113L(3)|p.L384L(3)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527000													5	142					0	0	0.217242	0	0
CALML5	51806	broad.mit.edu	37	10	5541246	5541246	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:5541246G>T	ENST00000380332.3	-	1	287	c.156C>A	c.(154-156)ctC>ctA	p.L52L		NM_017422.4	NP_059118.2	Q9NZT1	CALL5_HUMAN	calmodulin-like 5	52	EF-hand 2.				epidermis development|signal transduction		calcium ion binding|protein binding			biliary_tract(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)|stomach(1)	8						CCTCGGAGATGAGTTTCCTTA	0.647000													11	51					2.27111e-07	2.57733e-07	0.411799	1	0
FAM47B	170062	broad.mit.edu	37	X	34961974	34961974	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:34961974C>A	ENST00000329357.5	+	1	1062	c.1026C>A	c.(1024-1026)tcC>tcA	p.S342S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	342										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ATCGGGTGTCCAGTTTCCTAC	0.577000													28	7					1.06801e-11	1.33999e-11	0.740014	1	0
MYO1F	4542	broad.mit.edu	37	19	8619594	8619594	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:8619594G>T	ENST00000338257.8	-	3	442	c.175C>A	c.(175-177)Ccc>Acc	p.P59T		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	59	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						TGCTTGAAGGGGTTTACAGAG	0.602000													42	18					6.4308e-24	9.9162e-24	0.870114	1	0
SCG2	7857	broad.mit.edu	37	2	224464016	224464016	+	Splice_Site	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:224464016T>A	ENST00000305409.2	-	2	219		c.e2-2			NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II						angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		AAAGATTTCCTTAAAACATAA	0.368000													18	37					0	0	0.592651	0	0
MPP4	58538	broad.mit.edu	37	2	202545596	202545596	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:202545596G>A	ENST00000409474.3	-	10	1101	c.894C>T	c.(892-894)tgC>tgT	p.C298C	MPP4_ENST00000428900.2_Silent_p.C298C|MPP4_ENST00000447335.2_Silent_p.C298C|MPP4_ENST00000409143.1_Silent_p.C271C|MPP4_ENST00000396886.3_Silent_p.C254C|MPP4_ENST00000359962.5_Silent_p.C298C|MPP4_ENST00000315506.7_Silent_p.C285C	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	298	SH3.					cytoplasm	protein binding			kidney(1)|lung(11)	12						CAAGCCCAGCGCAGGTAGCAG	0.532000											OREG0015145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	14					0	0	0.520397	0	0
CLSTN2	64084	broad.mit.edu	37	3	140122646	140122646	+	Silent	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:140122646A>T	ENST00000458420.3	+	3	598	c.408A>T	c.(406-408)acA>acT	p.T136T		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	136	Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						CCCACGAGACAGCCTGGAAAA	0.582000										HNSCC(16;0.037)			29	45					0	0	0.779181	0	0
EPHA5	2044	broad.mit.edu	37	4	66356194	66356194	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:66356194T>A	ENST00000273854.3	-	5	1903	c.1303A>T	c.(1303-1305)Aca>Tca	p.T435S	EPHA5_ENST00000432638.2_Intron|EPHA5_ENST00000511294.1_Missense_Mutation_p.T435S|EPHA5_ENST00000354839.4_Missense_Mutation_p.T435S	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	435	Fibronectin type-III 1.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						GTATAGTTTGTGTGAGCGAGT	0.517000										TSP Lung(17;0.13)			31	39					0	0	0.788014	0	0
MUC5B	727897	broad.mit.edu	37	11	1264283	1264283	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:1264283G>C	ENST00000447027.1	+	31	6240	c.6182G>C	c.(6181-6183)gGc>gCc	p.G2061A	MUC5B_ENST00000529681.1_Missense_Mutation_p.G2058A|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2058	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACAACCACGGGCTTCACAGCC	0.652000													37	149					0	0	0.853193	0	0
PSG2	5670	broad.mit.edu	37	19	43579556	43579556	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:43579556C>T	ENST00000406487.1	-	3	757	c.659G>A	c.(658-660)cGg>cAg	p.R220Q		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	220	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				CCCTGAGTTCCGTATTTCACA	0.502000													124	222					0	0	0.870114	0	0
FAM179A	165186	broad.mit.edu	37	2	29247040	29247040	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:29247040C>T	ENST00000379558.4	+	13	2004	c.1653C>T	c.(1651-1653)gcC>gcT	p.A551A	FAM179A_ENST00000465300.1_3'UTR|FAM179A_ENST00000403861.2_Silent_p.A496A	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	551							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTCACCTGGCCATCAGCACCT	0.612000													10	7					0	0	0.435327	0	0
PPP1R16A	84988	broad.mit.edu	37	8	145727030	145727030	+	Missense_Mutation	SNP	C	C	A	rs141554257		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:145727030C>A	ENST00000292539.4	+	11	2248	c.1331C>A	c.(1330-1332)cCc>cAc	p.P444H	PPP1R16A_ENST00000435887.1_Missense_Mutation_p.P444H			Q96I34	PP16A_HUMAN	protein phosphatase 1, regulatory subunit 16A	444						plasma membrane	protein binding			NS(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)	8	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			AGCACCACCCCCCACACCCTG	0.667000													5	36					5.18039e-06	5.72868e-06	0.278610	1	0
HPD	3242	broad.mit.edu	37	12	122284985	122284985	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:122284985C>T	ENST00000543163.1	-	11	1060	c.615G>A	c.(613-615)gcG>gcA	p.A205A	HPD_ENST00000543869.2_5'UTR|HPD_ENST00000289004.4_Silent_p.A244A	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	244					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TCTTGCCAGGCGCTGGCTCAT	0.592000													26	93					0	0	0.750413	0	0
OR10K2	391107	broad.mit.edu	37	1	158390239	158390239	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:158390239C>T	ENST00000314902.2	-	1	417	c.418G>A	c.(418-420)Gtg>Atg	p.V140M		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					CCCATACACACCCCATGTCCC	0.502000													29	177					0	0	0.796494	0	0
UBXN4	23190	broad.mit.edu	37	2	136528276	136528276	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:136528276C>T	ENST00000272638.9	+	8	1104	c.793C>T	c.(793-795)Cga>Tga	p.R265*	UBXN4_ENST00000490163.1_3'UTR	NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	265					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						TAGGGCAGCTCGAGAACGTAT	0.363000													8	22					0	0	0.361761	0	0
MAGI1	9223	broad.mit.edu	37	3	65425585	65425585	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:65425585C>T	ENST00000330909.8	-	9	1238	c.1239G>A	c.(1237-1239)caG>caA	p.Q413Q	MAGI1_ENST00000470990.1_5'UTR|MAGI1_ENST00000497477.2_Silent_p.Q413Q|MAGI1_ENST00000483466.1_Silent_p.Q413Q|MAGI1_ENST00000402939.2_Silent_p.Q413Q	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	413	Poly-Gln.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		gctgctgctgctgctgttgct	0.537000											OREG0015658	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	45					0	0	0.150653	0	0
CCKBR	887	broad.mit.edu	37	11	6292588	6292588	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:6292588C>A	ENST00000525462.1	+	4	1369	c.1366C>A	c.(1366-1368)Ccc>Acc	p.P456T	CCKBR_ENST00000532715.1_Missense_Mutation_p.P303T|CCKBR_ENST00000334619.2_Missense_Mutation_p.P387T			P32239	GASR_HUMAN	cholecystokinin B receptor	387					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	CTGTGTCAACCCCCTGGTCTA	0.652000													25	109					2.90539e-05	3.13286e-05	0.729181	1	0
PKD2L2	27039	broad.mit.edu	37	5	137257391	137257391	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:137257391C>A	ENST00000508883.1	+	9	1421	c.1395C>A	c.(1393-1395)atC>atA	p.I465I	PKD2L2_ENST00000508638.1_Intron|PKD2L2_ENST00000502810.1_Silent_p.I443I|PKD2L2_ENST00000290431.5_Silent_p.I465I|PKD2L2_ENST00000350250.4_Silent_p.I431I			Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	465						integral to membrane	calcium ion binding|ion channel activity			breast(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|skin(1)|upper_aerodigestive_tract(2)	28			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CCAATCCTATCTTGGGACCCA	0.303000													33	8					1.69901e-12	2.18136e-12	0.812448	1	0
POTEE	445582	broad.mit.edu	37	2	131976233	131976233	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:131976233C>T	ENST00000356920.5	+	1	352	c.258C>T	c.(256-258)caC>caT	p.H86H	PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Silent_p.H86H|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	86							ATP binding										CTGGAGACCACGACGACTCTG	0.602000													34	82					0	0	0.864702	0	0
USP29	57663	broad.mit.edu	37	19	57642466	57642466	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:57642466A>T	ENST00000254181.4	+	4	2877	c.2423A>T	c.(2422-2424)aAg>aTg	p.K808M	USP29_ENST00000598197.1_Missense_Mutation_p.K808M	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	808					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGTGAAGCCAAGGAACTAACA	0.483000													9	12					0	0	0.335167	0	0
CACNA1A	773	broad.mit.edu	37	19	13414675	13414675	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:13414675G>A	ENST00000360228.5	-	16	2009	c.2010C>T	c.(2008-2010)aaC>aaT	p.N670N	CACNA1A_ENST00000573710.2_Silent_p.N671N	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	671					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	ACATGACCTCGTTCCAGTCTT	0.582000													100	147					0	0	0.870114	0	0
DNAH9	1770	broad.mit.edu	37	17	11687628	11687628	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:11687628C>A	ENST00000262442.3	+	41	7901	c.7833C>A	c.(7831-7833)agC>agA	p.S2611R	DNAH9_ENST00000454412.2_Missense_Mutation_p.S2611R	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2611	AAA 3 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GTCACTTCAGCGTGTTTGTCC	0.507000													87	380					6.23295e-54	1.12751e-53	0.870114	1	0
MYT1L	23040	broad.mit.edu	37	2	1926499	1926499	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:1926499C>A	ENST00000399161.2	-	10	1789	c.1042G>T	c.(1042-1044)Gag>Tag	p.E348*	MYT1L_ENST00000428368.2_Nonsense_Mutation_p.E348*	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	348					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GGATTCCTCTCCTGCGGGTTG	0.572000													13	42					6.31663e-08	7.29119e-08	0.479597	1	0
MARCH6	10299	broad.mit.edu	37	5	10402693	10402693	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:10402693G>A	ENST00000274140.5	+	14	1303	c.1171G>A	c.(1171-1173)Ggt>Agt	p.G391S	MARCH6_ENST00000510792.1_Missense_Mutation_p.G89S|MARCH6_ENST00000449913.2_Missense_Mutation_p.G343S|MARCH6_ENST00000503788.1_Missense_Mutation_p.G286S	NM_005885.2	NP_005876.2	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	391					protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(35)|ovary(1)|urinary_tract(3)	54						TCTCATTTGTGGTTGGTGGCT	0.363000													86	715					0	0	0.870114	0	0
OR13F1	138805	broad.mit.edu	37	9	107266605	107266605	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:107266605C>A	ENST00000334726.2	+	1	151	c.62C>A	c.(61-63)cCc>cAc	p.P21H		NM_001004485.1	NP_001004485.1	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F, member 1	21					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						TTTCACTACCCCAAAGTTCAG	0.408000													27	45					7.38237e-10	8.8239e-10	0.706142	1	0
GNG8	94235	broad.mit.edu	37	19	47137359	47137359	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:47137359T>G	ENST00000300873.4	-	2	189	c.187A>C	c.(187-189)Aag>Cag	p.K63Q		NM_033258.1	NP_150283.1	Q9UK08	GBG8_HUMAN	guanine nucleotide binding protein (G protein), gamma 8	63					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|synaptic transmission	extracellular region|heterotrimeric G-protein complex	GTPase activity|signal transducer activity						Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.000621)|Epithelial(262;0.0171)|GBM - Glioblastoma multiforme(486;0.0325)		AAGAGGCGCTTGTCGCGGAAG	0.597000													23	22					0	0	0.693898	0	0
GJB3	2707	broad.mit.edu	37	1	35250702	35250702	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:35250702C>T	ENST00000373366.2	+	2	954	c.339C>T	c.(337-339)tgC>tgT	p.C113C	GJB3_ENST00000373362.3_Silent_p.C113C|RP1-34M23.5_ENST00000542839.1_RNA	NM_024009.2	NP_076872.1	O75712	CXB3_HUMAN	gap junction protein, beta 3, 31kDa	113					cell communication	connexon complex|integral to membrane	gap junction channel activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(2)|prostate(3)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				GGGACCAGTGCGCCAAGCTGT	0.602000													30	62					0	0	0.760397	0	0
GATA6	2627	broad.mit.edu	37	18	19780748	19780748	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:19780748G>T	ENST00000269216.3	+	7	2027	c.1750G>T	c.(1750-1752)Gtg>Ttg	p.V584L	GATA6_ENST00000581694.1_Missense_Mutation_p.V584L|RP11-627G18.1_ENST00000583442.1_RNA	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	584					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			CACGTCCTCCGTGCGACCGGA	0.662000													23	21					7.38237e-10	8.8239e-10	0.706142	1	0
CD200R1L	344807	broad.mit.edu	37	3	112538736	112538736	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:112538736C>A	ENST00000488794.1	-	7	1212	c.623G>T	c.(622-624)aGa>aTa	p.R208I	CD200R1L_ENST00000398214.1_Missense_Mutation_p.R229I|CD200R1L_ENST00000448932.1_Missense_Mutation_p.R208I			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	229	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						TCCTGAGGTTCTGAGACCTTT	0.348000													26	39					1.74807e-11	2.18419e-11	0.750413	1	0
SSPO	23145	broad.mit.edu	37	7	149521602	149521602	+	RNA	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:149521602G>T	ENST00000378016.2	+	0	13681							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGACCCAACTGGCCTCTCCCC	0.711000													22	55					1.08312e-15	1.47168e-15	0.740014	1	0
PLXNA4	91584	broad.mit.edu	37	7	131831290	131831290	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:131831290C>A	ENST00000359827.3	-	28	5996	c.5034G>T	c.(5032-5034)ctG>ctT	p.L1678L	PLXNA4_ENST00000321063.4_Silent_p.L1678L			Q9HCM2	PLXA4_HUMAN	plexin A4	1678						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GGAGTCGGGTCAGGTAGATTT	0.562000													104	317					5.753e-54	1.04381e-53	0.870114	1	0
MIR129-1	406917	broad.mit.edu	37	7	127847924	127847924	+	RNA	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:127847924T>A	ENST00000384972.1	+	0	1					NR_029596.1																						CTGTCTCCTTTGGATCTTTTT	0.607000													3	17					0	0	0.150653	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110463299	110463299	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:110463299C>A	ENST00000378402.5	+	41	6375	c.6271C>A	c.(6271-6273)Cca>Aca	p.P2091T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2091	IPT/TIG 14.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GTCACTGACTCCACTCATCAC	0.517000										HNSCC(38;0.096)	OREG0018931	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	69					2.32416e-17	3.26028e-17	0.624587	1	0
KCNJ16	3773	broad.mit.edu	37	17	68128272	68128272	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:68128272C>A	ENST00000585558.1	+	4	537	c.149C>A	c.(148-150)gCa>gAa	p.A50E	KCNJ16_ENST00000589377.1_Missense_Mutation_p.A15E|KCNJ16_ENST00000586462.1_Missense_Mutation_p.A54E|KCNJ16_ENST00000283936.1_Missense_Mutation_p.A15E|KCNJ16_ENST00000392670.1_Missense_Mutation_p.A15E|KCNJ16_ENST00000392671.1_Missense_Mutation_p.A15E			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	15					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					AATGCGGACGCAAAATACCCA	0.438000													14	63					2.62699e-14	3.49113e-14	0.479597	1	0
RYR2	6262	broad.mit.edu	37	1	237664091	237664091	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:237664091A>T	ENST00000366574.2	+	21	2601	c.2284A>T	c.(2284-2286)Agt>Tgt	p.S762C	RYR2_ENST00000360064.6_Missense_Mutation_p.S760C|RYR2_ENST00000542537.1_Missense_Mutation_p.S746C	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	762	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTAGATCTGAGTGCCCCAAG	0.418000													78	263					0	0	0.870114	0	0
C10orf62	414157	broad.mit.edu	37	10	99350165	99350165	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:99350165C>T	ENST00000370640.3	+	1	716	c.511C>T	c.(511-513)Ctc>Ttc	p.L171F	HOGA1_ENST00000370646.4_Intron|PI4K2A_ENST00000555577.1_Intron|HOGA1_ENST00000370647.4_Intron|PI4K2A_ENST00000370649.3_Intron	NM_001009997.2	NP_001009997.2	Q5T681	CJ062_HUMAN	chromosome 10 open reading frame 62	171							protein binding			endometrium(2)|kidney(1)|lung(1)	4		Colorectal(252;0.162)		Epithelial(162;9.58e-11)|all cancers(201;8.62e-09)		GCTGAGGGCCCTCGAGGAGGT	0.567000													36	57					0	0	0.870114	0	0
HAT1	8520	broad.mit.edu	37	2	172841109	172841109	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:172841109C>T	ENST00000264108.4	+	9	873	c.837C>T	c.(835-837)tcC>tcT	p.S279S	HAT1_ENST00000392584.1_Silent_p.S194S|SLC25A12_ENST00000472748.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	279					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AAGATCCATCCAAAAGCTATG	0.328000													10	43					0	0	0.479597	0	0
ABCC9	10060	broad.mit.edu	37	12	22069983	22069983	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:22069983T>C	ENST00000261200.4	-	4	460	c.461A>G	c.(460-462)aAg>aGg	p.K154R	ABCC9_ENST00000345162.2_Missense_Mutation_p.K154R|ABCC9_ENST00000261201.4_Missense_Mutation_p.K154R	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	154					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTGACAGTACTTAACCAATTT	0.388000													12	534					0	0	0.520397	0	0
FLNC	2318	broad.mit.edu	37	7	128482943	128482943	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:128482943T>C	ENST00000325888.8	+	16	2746	c.2485T>C	c.(2485-2487)Ttc>Ctc	p.F829L	FLNC_ENST00000346177.6_Missense_Mutation_p.F829L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	829					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CAACGACACCTTCACCGTCAA	0.587000													21	64					0	0	0.667858	0	0
UTRN	7402	broad.mit.edu	37	6	144852199	144852199	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:144852199G>T	ENST00000367545.3	+	41	5918	c.5918G>T	c.(5917-5919)aGg>aTg	p.R1973M		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1973					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TGTTTTGACAGGGCAATGGAA	0.378000													10	15					0.457914	0.45943	0.457914	1	0
ELP5	23587	broad.mit.edu	37	17	7155850	7155850	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:7155850G>T	ENST00000574993.1	+	1	246	c.29G>T	c.(28-30)gGg>gTg	p.G10V	ELP5_ENST00000354429.2_Missense_Mutation_p.G10V|ELP5_ENST00000396627.2_Missense_Mutation_p.G10V|ELP5_ENST00000574255.1_Missense_Mutation_p.G10V|ELP5_ENST00000356683.2_Missense_Mutation_p.G10V|ELP5_ENST00000396628.2_Missense_Mutation_p.G10V|ELP5_ENST00000573657.1_Missense_Mutation_p.G10V|RP1-4G17.5_ENST00000577138.1_Intron					elongator acetyltransferase complex subunit 5																		GCCAGAGCAGGGACCGGACGC	0.667000													26	37					6.07407e-21	8.97778e-21	0.717897	1	0
TACC2	10579	broad.mit.edu	37	10	123970691	123970691	+	Missense_Mutation	SNP	G	G	C	rs114482287	byFrequency	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:123970691G>C	ENST00000369005.1	+	9	7091	c.6751G>C	c.(6751-6753)Ggg>Cgg	p.G2251R	TACC2_ENST00000515603.1_Missense_Mutation_p.G2206R|TACC2_ENST00000360561.3_Missense_Mutation_p.G329R|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000513429.1_Missense_Mutation_p.G397R|TACC2_ENST00000453444.2_Missense_Mutation_p.G2255R|TACC2_ENST00000334433.3_Missense_Mutation_p.G2251R|TACC2_ENST00000369004.3_Missense_Mutation_p.G329R|TACC2_ENST00000368999.1_Missense_Mutation_p.G329R|TACC2_ENST00000515273.1_Missense_Mutation_p.G2255R|TACC2_ENST00000358010.1_Missense_Mutation_p.G397R|TACC2_ENST00000260733.3_Missense_Mutation_p.G329R|TACC2_ENST00000369001.1_5'UTR	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2251						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ATCGGATAGCGGGGGGCAAGA	0.597000													10	34					0	0	0.435327	0	0
RIMS2	9699	broad.mit.edu	37	8	104922627	104922627	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:104922627A>G	ENST00000262231.10	+	3	1375	c.1127A>G	c.(1126-1128)aAg>aGg	p.K376R	RIMS2_ENST00000507740.1_Intron|RIMS2_ENST00000436393.2_Intron|RIMS2_ENST00000406091.3_Intron			Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	599					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GAGAGACAAAAGGAAATGATG	0.438000										HNSCC(12;0.0054)			4	110					0	0	0.248553	0	0
C1orf94	84970	broad.mit.edu	37	1	34663306	34663306	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:34663306G>T	ENST00000488417.1	+	2	921	c.801G>T	c.(799-801)aaG>aaT	p.K267N	C1orf94_ENST00000373374.3_Missense_Mutation_p.K77N	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	77							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				GGGTCACCAAGGACTTCCTAC	0.572000													31	24					1.22384e-17	1.72075e-17	0.769981	1	0
PPCDC	60490	broad.mit.edu	37	15	75320694	75320694	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:75320694C>A	ENST00000342932.3	+	2	179	c.35C>A	c.(34-36)cCc>cAc	p.P12H	PPCDC_ENST00000567336.1_Missense_Mutation_p.P12H|PPCDC_ENST00000564923.1_Missense_Mutation_p.P12H|PPCDC_ENST00000568649.1_Missense_Mutation_p.P12H	NM_021823.3	NP_068595.3	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase	12					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenoylcysteine decarboxylase activity			breast(1)|cervix(1)	2						GCTGCTGCACCCTTGATGGAG	0.552000													13	25					6.72482e-11	8.33383e-11	0.479597	1	0
KRTAP10-8	386681	broad.mit.edu	37	21	46032183	46032183	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr21:46032183T>C	ENST00000334662.2	+	1	188	c.166T>C	c.(166-168)Tgt>Cgt	p.C56R	TSPEAR_ENST00000323084.4_Intron	NM_198695.2	NP_941968.2	P60410	KR108_HUMAN	keratin associated protein 10-8	56	19 X 5 AA repeats of C-C-X(3).					keratin filament				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	17						GCCCCGCTCCTGTGCCTCCAG	0.672000													31	90					0	0	0.750413	0	0
GPNMB	10457	broad.mit.edu	37	7	23296663	23296663	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:23296663A>G	ENST00000258733.4	+	4	815	c.520A>G	c.(520-522)Atc>Gtc	p.I174V	GPNMB_ENST00000453162.2_Intron|GPNMB_ENST00000381990.2_Missense_Mutation_p.I174V|GPNMB_ENST00000409458.3_Missense_Mutation_p.I174V|GPNMB_ENST00000539136.1_Missense_Mutation_p.I75V			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	174					negative regulation of cell proliferation	melanosome				breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			ATGGAATTTCATCTACGTCTT	0.443000													37	88					0	0	0.870114	0	0
MYPN	84665	broad.mit.edu	37	10	69966659	69966659	+	Splice_Site	SNP	C	C	A	rs142307556	byFrequency	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:69966659C>A	ENST00000358913.5	+	19	4280	c.3793_splice	c.e19+1	p.Y1264_splice	MYPN_ENST00000540630.1_Splice_Site_p.Y1264_splice|MYPN_ENST00000354393.2_Splice_Site_p.Y989_splice	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1264	Interaction with ACTN.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TGGATATATACGGTAAGTGTA	0.443000													16	14					2.4624e-09	2.9088e-09	0.575678	1	0
DUSP26	78986	broad.mit.edu	37	8	33449635	33449635	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:33449635C>A	ENST00000256261.4	-	4	1049	c.532G>T	c.(532-534)Gcc>Tcc	p.A178S	DUSP26_ENST00000523956.1_Missense_Mutation_p.A178S	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	178	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		TTCTTGATGGCCTCCACGAGG	0.627000													31	18					9.17885e-22	1.37683e-21	0.779181	1	0
POU3F4	5456	broad.mit.edu	37	X	82763989	82763989	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:82763989G>T	ENST00000373200.2	+	1	721	c.657G>T	c.(655-657)ctG>ctT	p.L219L	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	219	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						GGTTGGCGCTGGGCACACTGT	0.522000													12	71					2.79863e-10	3.39194e-10	0.681144	1	0
CYP24A1	1591	broad.mit.edu	37	20	52775623	52775623	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:52775623G>C	ENST00000216862.3	-	8	1423	c.1030C>G	c.(1030-1032)Cgt>Ggt	p.R344G	CYP24A1_ENST00000395954.3_Missense_Mutation_p.R202G|CYP24A1_ENST00000395955.3_Missense_Mutation_p.R344G	NM_000782.4	NP_000773.2	Q07973	CP24A_HUMAN	cytochrome P450, family 24, subfamily A, polypeptide 1	344					hormone biosynthetic process|osteoblast differentiation|vitamin D catabolic process|vitamin D receptor signaling pathway|xenobiotic metabolic process	mitochondrial inner membrane	1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity|electron carrier activity|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen			breast(2)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(4;1.08e-05)|all_lung(4;2.7e-05)		STAD - Stomach adenocarcinoma(23;0.206)		Calcidiol(DB00146)|Calcitriol(DB00136)|Cholecalciferol(DB00169)|Ergocalciferol(DB00153)|Paricalcitol(DB00910)	TGGGGATTACGGGATAAATTG	0.378000													56	31					0	0	0.870114	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113558659	113558659	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:113558659C>A	ENST00000284601.3	-	1	461	c.393G>T	c.(391-393)gaG>gaT	p.E131D		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	131	CBM21.				glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ACTCAGTTGACTCCAGTATTG	0.353000													19	52					1.10923e-09	1.32322e-09	0.639603	1	0
SOGA2	23255	broad.mit.edu	37	18	8825652	8825652	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:8825652G>A	ENST00000359865.3	+	15	4286	c.4144G>A	c.(4144-4146)Gaa>Aaa	p.E1382K	SOGA2_ENST00000306329.11_Missense_Mutation_p.E1701K|SOGA2_ENST00000306285.7_Missense_Mutation_p.E707K|SOGA2_ENST00000518815.1_Missense_Mutation_p.E707K|SOGA2_ENST00000400050.3_Missense_Mutation_p.E1341K|SOGA2_ENST00000517570.1_Missense_Mutation_p.E1341K	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	1692																	GGCCAAGTTTGAACGCACATG	0.612000													9	25					0	0	0.387290	0	0
RIT1	6016	broad.mit.edu	37	1	155870234	155870234	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:155870234C>G	ENST00000368323.3	-	6	809	c.605G>C	c.(604-606)aGt>aCt	p.S202T	RIT1_ENST00000461050.1_5'UTR|RIT1_ENST00000539040.1_Missense_Mutation_p.S166T|RIT1_ENST00000368322.3_Missense_Mutation_p.S219T	NM_006912.5	NP_008843.1	Q92963	RIT1_HUMAN	Ras-like without CAAX 1	202					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|skin(1)|urinary_tract(1)	19	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;1.79e-05)			CTTCCATACACTGTTTTTGGG	0.403000													79	507					0	0	0.870114	0	0
ZP4	57829	broad.mit.edu	37	1	238046127	238046127	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:238046127G>T	ENST00000366570.4	-	11	1568	c.1410C>A	c.(1408-1410)aaC>aaA	p.N470K	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	470					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCTGAGAACTGTTGTCAAAAT	0.423000													17	62					4.7546e-09	5.57309e-09	0.500413	1	0
CCDC150	284992	broad.mit.edu	37	2	197541439	197541439	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:197541439A>G	ENST00000389175.4	+	12	1559	c.1424A>G	c.(1423-1425)gAa>gGa	p.E475G	CCDC150_ENST00000272831.7_Missense_Mutation_p.E143G|CCDC150_ENST00000423093.2_Missense_Mutation_p.E143G|CCDC150_ENST00000472405.2_3'UTR	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	475										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						GAGGAGAAAGAAAGATTTCAG	0.373000													18	60					0	0	0.639603	0	0
P4HA1	5033	broad.mit.edu	37	10	74813307	74813307	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:74813307C>A	ENST00000412021.2	-	7	838	c.505G>T	c.(505-507)Gag>Tag	p.E169*	P4HA1_ENST00000394890.2_Nonsense_Mutation_p.E169*|P4HA1_ENST00000307116.2_Nonsense_Mutation_p.E169*|P4HA1_ENST00000263556.3_Nonsense_Mutation_p.E169*|P4HA1_ENST00000373008.2_Nonsense_Mutation_p.E169*|P4HA1_ENST00000440381.1_Nonsense_Mutation_p.E169*	NM_001142595.1	NP_001136067.1	P13674	P4HA1_HUMAN	prolyl 4-hydroxylase, alpha polypeptide I	169						endoplasmic reticulum lumen|mitochondrion	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	15	Prostate(51;0.0198)				Hydralazine(DB01275)|L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	TTGCCCAACTCAAAGCAGTCC	0.398000													18	73					1.50039e-11	1.87859e-11	0.608945	1	0
NRCAM	4897	broad.mit.edu	37	7	107820809	107820809	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:107820809G>A	ENST00000379028.3	-	25	3179	c.2709C>T	c.(2707-2709)atC>atT	p.I903I	NRCAM_ENST00000425651.2_Silent_p.I903I|NRCAM_ENST00000413765.2_Silent_p.I884I|NRCAM_ENST00000379022.4_Silent_p.I903I|NRCAM_ENST00000379024.4_Silent_p.I884I|NRCAM_ENST00000351718.4_Silent_p.I887I			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	903	Fibronectin type-III 3.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						GGAAGGTGAGGATCTTTTTCT	0.473000													22	23					0	0	0.667858	0	0
SEPT1	1731	broad.mit.edu	37	16	30391298	30391298	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:30391298G>T	ENST00000321367.3	-	8	801	c.756C>A	c.(754-756)gaC>gaA	p.D252E	SEPT1_ENST00000605106.1_Missense_Mutation_p.D210E|SEPT1_ENST00000571393.1_Missense_Mutation_p.D205E	NM_052838.4	NP_443070.5	Q8WYJ6	SEPT1_HUMAN	septin 1	205					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			breast(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)|urinary_tract(1)	24			Colorectal(24;0.193)			CTTCATCAGAGTCACATTCGG	0.507000													67	58					5.42381e-49	9.72434e-49	0.870114	1	0
PDGFRB	5159	broad.mit.edu	37	5	149509368	149509368	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:149509368G>A	ENST00000261799.4	-	10	2000	c.1531C>T	c.(1531-1533)Cgc>Tgc	p.R511C		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	511	Ig-like C2-type 5.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	ACAGCGTTGCGCAGCGTGCAG	0.622000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""						OREG0016927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	6					0	0	0.819951	0	0
TRIM21	6737	broad.mit.edu	37	11	4411619	4411619	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:4411619C>A	ENST00000254436.7	-	2	133	c.21G>T	c.(19-21)ttG>ttT	p.L7F	TRIM21_ENST00000543625.1_Missense_Mutation_p.L7F	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	7					cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		ACATCATTGTCAAGCGTGCTG	0.532000													17	82					3.8784e-16	5.30545e-16	0.608945	1	0
SMG6	23293	broad.mit.edu	37	17	2203823	2203823	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:2203823T>A	ENST00000544865.1	-	2	641	c.131A>T	c.(130-132)aAa>aTa	p.K44I	SMG6_ENST00000263073.5_Missense_Mutation_p.K75I			Q86US8	EST1A_HUMAN	SMG6 nonsense mediated mRNA decay factor	75					mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation|telomere maintenance	chromosome, telomeric region|cytosol|nucleolus|telomerase holoenzyme complex	endoribonuclease activity|metal ion binding|protein binding|telomeric DNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(7)|lung(10)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AATTTCATCTTTGAATTCCTC	0.448000													39	60					0	0	0.870114	0	0
UNC13A	23025	broad.mit.edu	37	19	17753678	17753678	+	Silent	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:17753678A>G	ENST00000428389.2	-	21	2711	c.2712T>C	c.(2710-2712)caT>caC	p.H904H	UNC13A_ENST00000519716.2_Silent_p.H816H|UNC13A_ENST00000252773.7_Silent_p.H816H|UNC13A_ENST00000552293.1_Silent_p.H816H|UNC13A_ENST00000551649.1_Silent_p.H816H|UNC13A_ENST00000550896.1_Silent_p.H814H			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	816					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						TGTACTGGACATGGTACGGGG	0.592000													8	6					0	0	0.335167	0	0
PEAR1	375033	broad.mit.edu	37	1	156877971	156877971	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:156877971G>T	ENST00000338302.3	+	10	1179	c.954G>T	c.(952-954)acG>acT	p.T318T	PEAR1_ENST00000292357.7_Silent_p.T318T			Q5VY43	PEAR1_HUMAN	platelet endothelial aggregation receptor 1	318	EGF-like 4.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(6)|lung(22)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)	43	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTGCTGAGACGTGCGACTGCG	0.716000													4	60					0.248553	0.250204	0.248553	1	0
ATG9B	285973	broad.mit.edu	37	7	150715482	150715482	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:150715482G>T	ENST00000605938.1	-	7	1846	c.1771C>A	c.(1771-1773)Cag>Aag	p.Q591K	ATG9B_ENST00000377974.2_Missense_Mutation_p.Q591K|ATG9B_ENST00000444312.1_Missense_Mutation_p.Q77K|ATG9B_ENST00000494791.1_5'UTR	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	591					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGGGCTGTCTGCAGCAGGAGC	0.692000											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	28					6.94344e-10	8.33213e-10	0.539581	1	0
PCDH7	5099	broad.mit.edu	37	4	30724787	30724787	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:30724787C>A	ENST00000361762.2	+	1	2751	c.1743C>A	c.(1741-1743)atC>atA	p.I581I	PCDH7_ENST00000543491.1_Silent_p.I581I	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	581	Cadherin 5.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						TGATGGGGATCTTTGCCATCG	0.572000													17	31					8.00594e-06	8.78913e-06	0.557998	1	0
FRMD4A	55691	broad.mit.edu	37	10	13789739	13789739	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:13789739T>C	ENST00000357447.2	-	9	913	c.545A>G	c.(544-546)tAc>tGc	p.Y182C	FRMD4A_ENST00000342409.2_Missense_Mutation_p.Y198C|FRMD4A_ENST00000378503.1_Missense_Mutation_p.Y182C|FRMD4A_ENST00000358621.4_Missense_Mutation_p.Y167C|RP11-353M9.1_ENST00000449462.1_RNA	NM_018027.3	NP_060497.3	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	182	FERM.					cytoplasm|cytoskeleton	binding			breast(4)|endometrium(9)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	41						GTCTTACCAGTAGGCCAGGGA	0.592000													20	75					0	0	0.592651	0	0
NTRK3	4916	broad.mit.edu	37	15	88690617	88690617	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:88690617C>A	ENST00000394480.1	-	6	734	c.413G>T	c.(412-414)cGg>cTg	p.R138L	NTRK3_ENST00000542733.2_Missense_Mutation_p.R40L|NTRK3_ENST00000357724.2_Missense_Mutation_p.R138L|NTRK3_ENST00000540489.2_Missense_Mutation_p.R138L|NTRK3_ENST00000557856.1_Missense_Mutation_p.R138L|NTRK3_ENST00000558676.1_Missense_Mutation_p.R138L|NTRK3_ENST00000360948.2_Missense_Mutation_p.R138L|NTRK3_ENST00000317501.3_Missense_Mutation_p.R138L|NTRK3_ENST00000355254.2_Missense_Mutation_p.R138L	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	138					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGTGGTGAGCCGGTTACTTGA	0.428000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			12	22					7.03913e-09	8.23496e-09	0.411799	1	0
ASRGL1	80150	broad.mit.edu	37	11	62156689	62156689	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:62156689A>T	ENST00000415229.2	+	5	791	c.576A>T	c.(574-576)aaA>aaT	p.K192N	ASRGL1_ENST00000535727.1_Missense_Mutation_p.K64N|ASRGL1_ENST00000301776.5_Missense_Mutation_p.K192N	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	192					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	TCGTTAATAAAATGGTCGGCC	0.552000													25	67					0	0	0.769981	0	0
DIP2C	22982	broad.mit.edu	37	10	329265	329265	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:329265C>A	ENST00000280886.6	-	35	4328	c.4241G>T	c.(4240-4242)cGc>cTc	p.R1414L		NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	1414						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GTAGCCTGTGCGTGCCCAGAT	0.547000													26	51					4.59853e-10	5.54018e-10	0.693898	1	0
ITGB2	3689	broad.mit.edu	37	21	46326915	46326915	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr21:46326915G>T	ENST00000397850.2	-	5	695	c.243C>A	c.(241-243)ccC>ccA	p.P81P	ITGB2_ENST00000355153.4_Silent_p.P81P|ITGB2_ENST00000302347.5_Silent_p.P81P|ITGB2_ENST00000397857.1_Silent_p.P81P|ITGB2_ENST00000397852.1_Silent_p.P81P|ITGB2_ENST00000397854.3_Silent_p.P81P			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	81					apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	CGAGGCTTGTGGGGTCCATGA	0.617000													75	52					8.34767e-46	1.49224e-45	0.870114	1	0
CFH	3075	broad.mit.edu	37	1	196696020	196696020	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:196696020G>T	ENST00000367429.4	+	14	2426	c.2186G>T	c.(2185-2187)aGa>aTa	p.R729I		NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	729	Sushi 12.				complement activation, alternative pathway	extracellular space				NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						ATTGGACACAGATCAATTACG	0.383000													26	141					6.00712e-18	8.48559e-18	0.760397	1	0
PCDHA10	56139	broad.mit.edu	37	5	140236161	140236161	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:140236161T>C	ENST00000307360.5	+	1	528	c.528T>C	c.(526-528)taT>taC	p.Y176Y	PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Silent_p.Y176Y|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAAATGAGTATTTTGTTCTTG	0.408000													27	39					0	0	0.717897	0	0
SLC8A1	6546	broad.mit.edu	37	2	40366681	40366681	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:40366681G>C	ENST00000406785.1	-	7	2486	c.2297C>G	c.(2296-2298)gCg>gGg	p.A766G	SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1_ENST00000332839.4_Missense_Mutation_p.A802G|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.A797G|SLC8A1_ENST00000542024.1_Missense_Mutation_p.A766G|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1_ENST00000408028.2_Missense_Mutation_p.A794G|SLC8A1_ENST00000406391.2_Missense_Mutation_p.A766G|SLC8A1_ENST00000405901.3_Missense_Mutation_p.A797G|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1_ENST00000405269.1_Missense_Mutation_p.A766G|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1_ENST00000403092.1_Missense_Mutation_p.A802G|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1_ENST00000402441.1_Missense_Mutation_p.A766G|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	802					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AATGAAACACGCCCAGCCATT	0.507000													49	36					0	0	0.870114	0	0
PRKCG	5582	broad.mit.edu	37	19	54410140	54410140	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:54410140C>T	ENST00000263431.3	+	18	2367	c.2085C>T	c.(2083-2085)ccC>ccT	p.P695P	PRKCG_ENST00000542049.1_Silent_p.P546P|PRKCG_ENST00000540413.1_Silent_p.P695P	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	695					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		TGCCTGTGCCCGTCATGTAAT	0.677000											OREG0025667	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	32					0	0	0.681144	0	0
ABCA13	154664	broad.mit.edu	37	7	48311621	48311621	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:48311621T>C	ENST00000435803.1	+	17	2382	c.2358T>C	c.(2356-2358)tcT>tcC	p.S786S		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	786					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAGACCCATCTGCCACTGATG	0.403000													7	28					0	0	0.278610	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142231979	142231979	+	RNA	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:142231979C>A	ENST00000390364.3	-	0	111																											CTCACCTGCCCACAGCAGACA	0.567000													22	44					1.2476e-16	1.7222e-16	0.706142	1	0
TRBV7-3	28595	broad.mit.edu	37	7	142247158	142247158	+	RNA	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:142247158G>T	ENST00000390361.3	-	0	347																											CGCTCTGTGCGCTGGATCTTC	0.567000													30	92					8.73648e-17	1.20875e-16	0.796494	1	0
ASPA	443	broad.mit.edu	37	17	3384912	3384912	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:3384912A>C	ENST00000263080.2	+	2	410	c.252A>C	c.(250-252)gaA>gaC	p.E84D	SPATA22_ENST00000541913.1_Intron|ASPA_ENST00000456349.2_Missense_Mutation_p.E84D	NM_000049.2	NP_000040.1	P45381	ACY2_HUMAN	aspartoacylase	84					aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|stomach(1)|urinary_tract(1)	17					L-Aspartic Acid(DB00128)	AAATGTCAGAAGATTTGCCAT	0.313000													8	17					0	0	0.361761	0	0
TP53	7157	broad.mit.edu	37	17	7576897	7576897	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:7576897G>A	ENST00000420246.2	-	9	1081	c.949C>T	c.(949-951)Cag>Tag	p.Q317*	TP53_ENST00000445888.2_Nonsense_Mutation_p.Q317*|TP53_ENST00000359597.4_Nonsense_Mutation_p.Q317*|TP53_ENST00000455263.2_Nonsense_Mutation_p.Q317*|TP53_ENST00000413465.2_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.Q317*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	317	Interaction with CARM1.|Interaction with HIPK1 (By similarity).		Q -> H (in a kidney cancer with no family history; germline mutation and in a sporadic cancer; somatic mutation).|Q -> K (in sporadic cancers; somatic mutation).|Q -> L (in a sporadic cancer; somatic mutation).|Q -> P (in a sporadic cancer; somatic mutation).|Q -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Q317*(29)|p.0?(8)|p.Q317K(3)|p.S315fs*22(1)|p.?(1)|p.S314fs*25(1)|p.L308fs*15(1)|p.Q317fs*28(1)|p.Q317fs*45(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTTTGGCTGGGGAGAGGAG	0.473000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			85	10					0	0	0.870114	0	0
NLRP3	114548	broad.mit.edu	37	1	247582177	247582177	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:247582177G>T	ENST00000366497.2	+	2	861	c.81G>T	c.(79-81)atG>atT	p.M27I	NLRP3_ENST00000366496.2_Missense_Mutation_p.M27I|NLRP3_ENST00000391827.2_Missense_Mutation_p.M27I|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.M27I|NLRP3_ENST00000348069.2_Missense_Mutation_p.M27I|NLRP3_ENST00000391828.3_Missense_Mutation_p.M27I	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	27	DAPIN.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AATTTAAGATGCACTTAGAGG	0.547000													15	24					0.000422831	0.000445628	0.500413	1	0
OR2H1	26716	broad.mit.edu	37	6	29430303	29430303	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:29430303G>C	ENST00000377136.1	+	4	1222	c.757G>C	c.(757-759)Gtc>Ctc	p.V253L	OR2H1_ENST00000396792.2_Missense_Mutation_p.V253L|OR2H1_ENST00000377132.1_Missense_Mutation_p.V253L|OR2H1_ENST00000377133.1_Missense_Mutation_p.V253L|OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000442615.1_Missense_Mutation_p.V253L			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CTACAGCTCAGTCATTGCTGT	0.537000													56	57					0	0	0.870114	0	0
IGFBP2	3485	broad.mit.edu	37	2	217525361	217525361	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:217525361G>T	ENST00000233809.4	+	2	653	c.524G>T	c.(523-525)aGt>aTt	p.S175I	IGFBP2_ENST00000456764.1_Missense_Mutation_p.S31I	NM_000597.2	NP_000588.2	P18065	IBP2_HUMAN	insulin-like growth factor binding protein 2, 36kDa	175					positive regulation of activated T cell proliferation|regulation of cell growth|regulation of insulin-like growth factor receptor signaling pathway	extracellular space	insulin-like growth factor I binding|insulin-like growth factor II binding			endometrium(2)|large_intestine(1)|lung(2)	5		Renal(323;0.0458)		Epithelial(149;2.9e-06)|all cancers(144;0.000223)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00968)		GGGGGAGGCAGTGCTGGCCGG	0.612000													14	45					1.02788e-11	1.29501e-11	0.520397	1	0
ZIM3	114026	broad.mit.edu	37	19	57647194	57647194	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:57647194C>A	ENST00000269834.1	-	5	896	c.511G>T	c.(511-513)Gcc>Tcc	p.A171S		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTTCTACAGGCATTACATTTC	0.378000													42	88					1.00776e-21	1.5079e-21	0.870114	1	0
NECAB2	54550	broad.mit.edu	37	16	84012099	84012099	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:84012099G>A	ENST00000305202.4	+	3	294	c.277G>A	c.(277-279)Gtc>Atc	p.V93I	NECAB2_ENST00000565691.1_Silent_p.A18A	NM_019065.2	NP_061938.2	Q7Z6G3	NECA2_HUMAN	N-terminal EF-hand calcium binding protein 2	93	EF-hand 1.				antibiotic biosynthetic process	cytoplasm	calcium ion binding|oxidoreductase activity|protein binding	p.V93I(1)		endometrium(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|stomach(2)|urinary_tract(1)	19						TGCAGATGGCGTCCTTAATGA	0.512000													39	113					0	0	0.870114	0	0
CCDC15	80071	broad.mit.edu	37	11	124857317	124857317	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:124857317G>T	ENST00000529051.1	+	8	1454	c.1195G>T	c.(1195-1197)Gag>Tag	p.E399*	CCDC15_ENST00000344762.5_Nonsense_Mutation_p.E399*			Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	399						centrosome				central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(1)	23	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		CCAGAGTATTGAGCTAGAAGA	0.453000													33	48					6.19805e-25	9.60619e-25	0.812448	1	0
UNC5A	90249	broad.mit.edu	37	5	176305065	176305065	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:176305065C>A	ENST00000329542.4	+	11	2080	c.1806C>A	c.(1804-1806)gcC>gcA	p.A602A	UNC5A_ENST00000261961.3_Silent_p.A562A	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	602					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGCCGGTGGCCTGCACCTCCC	0.667000													22	40					1.5548e-18	2.23272e-18	0.693898	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885873	88885873	+	Silent	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:88885873G>C	ENST00000319675.3	-	1	423	c.327C>G	c.(325-327)acC>acG	p.T109T		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	109										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GGAGCTCAGGGGTCGTCAGGC	0.542000													69	58					0	0	0.870114	0	0
CARD6	84674	broad.mit.edu	37	5	40843720	40843720	+	Silent	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:40843720A>T	ENST00000254691.5	+	2	949	c.750A>T	c.(748-750)tcA>tcT	p.S250S	CARD6_ENST00000381677.3_Silent_p.S250S	NM_032587.3	NP_115976.2	Q9BX69	CARD6_HUMAN	caspase recruitment domain family, member 6	250	Asp/Glu-rich.				apoptosis|regulation of apoptosis	intracellular				NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(2)|lung(29)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	62						TCGAGAATTCAGAAACCACAG	0.458000													9	90					0	0	0.361761	0	0
CTSH	1512	broad.mit.edu	37	15	79215420	79215420	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:79215420C>A	ENST00000220166.5	-	11	956	c.847G>T	c.(847-849)Gta>Tta	p.V283L	CTSH_ENST00000534533.1_5'UTR	NM_004390.3	NP_004381.2	P09668	CATH_HUMAN	cathepsin H	283					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)	10						ACAGCCAGTACTGCATGGTTT	0.443000													15	24					4.75885e-15	6.39437e-15	0.520397	1	0
MEGF10	84466	broad.mit.edu	37	5	126753489	126753489	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:126753489T>G	ENST00000274473.6	+	11	1557	c.1290T>G	c.(1288-1290)tgT>tgG	p.C430W	MEGF10_ENST00000503335.2_Missense_Mutation_p.C430W|MEGF10_ENST00000508365.1_Missense_Mutation_p.C430W|MEGF10_ENST00000418761.2_Missense_Mutation_p.C430W	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	430	EGF-like 7.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGTGCACCTGTGCCCCAGGAT	0.507000													23	5					0	0	0.729181	0	0
IGSF11	152404	broad.mit.edu	37	3	118648995	118648995	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:118648995C>A	ENST00000354673.2	-	4	557	c.177G>T	c.(175-177)atG>atT	p.M59I	IGSF11_ENST00000489689.1_Missense_Mutation_p.M60I|IGSF11_ENST00000425327.2_Missense_Mutation_p.M59I|IGSF11_ENST00000459718.1_5'UTR|IGSF11_ENST00000393775.2_Missense_Mutation_p.M60I|IGSF11_ENST00000491903.1_Missense_Mutation_p.M60I|IGSF11_ENST00000441144.2_Missense_Mutation_p.M59I	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	60	Ig-like V-type.				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GAGGAGTGACCATCCAAATGA	0.522000													34	68					1.36161e-19	1.97875e-19	0.796494	1	0
PSG4	5672	broad.mit.edu	37	19	43708110	43708110	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:43708110A>G	ENST00000405312.3	-	2	595	c.358T>C	c.(358-360)Tac>Cac	p.Y120H	PSG4_ENST00000433626.2_Missense_Mutation_p.Y120H|PSG4_ENST00000244295.9_Missense_Mutation_p.Y120H	NM_002780.3	NP_002771.2	Q00888	PSG4_HUMAN	pregnancy specific beta-1-glycoprotein 4	120	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	24		Prostate(69;0.00682)				TGTAAGGTGTAGGATCCTGCA	0.473000													78	131					0	0	0.870114	0	0
MAP3K14	9020	broad.mit.edu	37	17	43341989	43341989	+	RNA	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:43341989G>T	ENST00000344686.2	-	0	2963				MAP3K14-AS1_ENST00000585346.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000585351.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA|MAP3K14-AS1_ENST00000586450.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA|MAP3K14-AS1_ENST00000585780.1_RNA|MAP3K14-AS1_ENST00000588504.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000590100.1_RNA			Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TGGAGCCGGCGGTGGAGGGCA	0.662000													6	6					0.0293803	0.0300751	0.248553	1	0
GCM1	8521	broad.mit.edu	37	6	52999124	52999124	+	Splice_Site	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:52999124T>C	ENST00000259803.7	-	3	287		c.e3-2			NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)							transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					TTTCACGTTCTGATAGAAACA	0.473000													23	39					0	0	0.654019	0	0
BMPR2	659	broad.mit.edu	37	2	203242242	203242242	+	Silent	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:203242242A>G	ENST00000374580.4	+	1	584	c.45A>G	c.(43-45)ccA>ccG	p.P15P	BMPR2_ENST00000374574.2_Silent_p.P15P	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	15					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						CCTGGCTACCATGGACCATCC	0.662000													30	92					0	0	0.769981	0	0
CSMD3	114788	broad.mit.edu	37	8	113678542	113678542	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:113678542G>T	ENST00000297405.5	-	17	3024	c.2780C>A	c.(2779-2781)gCt>gAt	p.A927D	CSMD3_ENST00000455883.2_Missense_Mutation_p.A823D|CSMD3_ENST00000352409.3_Missense_Mutation_p.A927D|CSMD3_ENST00000343508.3_Missense_Mutation_p.A887D	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	927	CUB 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCCAGGTTCAGCTTCAATCAC	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			46	22					1.27862e-28	2.07733e-28	0.870114	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21011448	21011448	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:21011448G>T	ENST00000381545.3	+	5	521	c.302G>T	c.(301-303)tGt>tTt	p.C101F	SLCO1B3_ENST00000545880.1_3'UTR|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.C101F|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.C101F|LST3_ENST00000381541.3_Missense_Mutation_p.C101F|LST3_ENST00000540229.1_Missense_Mutation_p.C101F|SLCO1B7_ENST00000554957.1_Missense_Mutation_p.C101F	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	101					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					GGAATTGGTTGTCTCCTTATG	0.333000													8	344					0.000274275	0.000289566	0.307466	1	0
LRRTM1	347730	broad.mit.edu	37	2	80530628	80530628	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:80530628C>A	ENST00000295057.3	-	2	973	c.317G>T	c.(316-318)gGg>gTg	p.G106V	CTNNA2_ENST00000466387.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.G106V|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000540488.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	106						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						AAAGGCGTCCCCCTGCACGGA	0.592000										HNSCC(69;0.2)			71	65					6.11987e-43	1.07497e-42	0.870114	1	0
LPPR4	9890	broad.mit.edu	37	1	99753707	99753707	+	Splice_Site	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:99753707G>C	ENST00000370185.3	+	2	905		c.e2+1		LPPR4_ENST00000457765.1_Splice_Site	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN									phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TGCAATTACGGTAAGAATTAC	0.408000													12	61					0	0	0.411799	0	0
GHR	2690	broad.mit.edu	37	5	42695191	42695191	+	Splice_Site	SNP	G	G	T	rs45501892		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:42695191G>T	ENST00000230882.4	+	5	629	c.439_splice	c.e5+1	p.V147_splice	GHR_ENST00000537449.1_5'UTR|GHR_ENST00000357703.3_Splice_Site_p.V125_splice	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	147					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGATGAAATAGGTAAATCACA	0.353000													29	95					3.86903e-22	5.83242e-22	0.769981	1	0
MAMDC2	256691	broad.mit.edu	37	9	72833383	72833383	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:72833383T>A	ENST00000377182.4	+	12	2399	c.1782T>A	c.(1780-1782)acT>acA	p.T594T	SMC5-AS1_ENST00000594708.1_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	594	MAM 4.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						GAGGGGGCACTGGCCTGCTGA	0.498000													22	31					0	0	0.681144	0	0
DTX4	23220	broad.mit.edu	37	11	58972340	58972340	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:58972340C>A	ENST00000227451.3	+	9	1922	c.1818C>A	c.(1816-1818)gcC>gcA	p.A606A	DTX4_ENST00000532982.1_Silent_p.A500A	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	606					Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				AACTGGCTGCCCAGGGCATCT	0.557000													7	6					0.0477658	0.0485672	0.307466	1	0
HGSNAT	138050	broad.mit.edu	37	8	43028855	43028855	+	Splice_Site	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:43028855G>A	ENST00000458501.2	+	9	904		c.e9-1		HGSNAT_ENST00000379644.4_Splice_Site			Q68CP4	HGNAT_HUMAN	heparan-alpha-glucosaminide N-acetyltransferase						lysosomal transport|protein oligomerization	integral to membrane|lysosomal membrane	heparan-alpha-glucosaminide N-acetyltransferase activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(6)	13	Prostate(17;0.0119)|Ovarian(28;0.0172)|Lung SC(25;0.184)	all_cancers(86;0.000223)|all_epithelial(80;1.61e-07)|all_lung(54;0.00021)|Lung NSC(58;0.000778)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.129)	Lung(22;0.0777)|LUSC - Lung squamous cell carcinoma(45;0.17)			TTGTTCTGCAGGGCTGACAGT	0.468000													19	16					0	0	0.667858	0	0
OR56A4	120793	broad.mit.edu	37	11	6023421	6023421	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:6023421T>A	ENST00000330728.4	-	1	1003	c.958A>T	c.(958-960)Agg>Tgg	p.R320W		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATTCTCTTCCTGGCCAGGTTA	0.542000													21	47					0	0	0.706142	0	0
ZNF229	7772	broad.mit.edu	37	19	44933222	44933222	+	Silent	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:44933222C>G	ENST00000291187.4	-	6	2038	c.1716G>C	c.(1714-1716)ggG>ggC	p.G572G	ZNF229_ENST00000588931.1_Silent_p.G578G|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	578					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GGAAGCCCTTCCCACACTCAC	0.567000													22	31					0	0	0.717897	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414889	14414889	+	RNA	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr21:14414889G>C	ENST00000507941.1	+	0	95																											TAGATAGAAAGTGCCAGCTTG	0.448000													7	58					0	0	0.278610	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763898	110763898	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:110763898G>T	ENST00000368919.3	-	4	798	c.732C>A	c.(730-732)gtC>gtA	p.V244V	SLC22A16_ENST00000456137.2_3'UTR|SLC22A16_ENST00000439654.1_Silent_p.V244V|SLC22A16_ENST00000330550.4_Silent_p.V210V	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	244					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		AATGCAAATGGACAGACGCCC	0.473000													32	7					1.99505e-19	2.87858e-19	0.760397	1	0
CALHM1	255022	broad.mit.edu	37	10	105218327	105218327	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:105218327G>T	ENST00000329905.5	-	1	318	c.182C>A	c.(181-183)cCc>cAc	p.P61H	RP11-225H22.4_ENST00000411906.1_RNA	NM_001001412.3	NP_001001412.3	Q8IU99	CAHM1_HUMAN	calcium homeostasis modulator 1	61						endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel activity|identical protein binding			large_intestine(2)|liver(1)|lung(5)|ovary(1)	9						GAGCACCAGGGGTGGCGCCAG	0.662000													19	33					9.39395e-14	1.22688e-13	0.706142	1	0
ZNF519	162655	broad.mit.edu	37	18	14106161	14106161	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:14106161C>T	ENST00000590202.1	-	3	530	c.378G>A	c.(376-378)aaG>aaA	p.K126K	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						ACTGAGGCTTCTTCTGAAATA	0.299000													6	50					0	0	0.335167	0	0
LAMC1	3915	broad.mit.edu	37	1	183093764	183093764	+	Splice_Site	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:183093764A>T	ENST00000258341.4	+	14	2658		c.e14-1			NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)						axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTCATCCCCAGGTAAGAGAT	0.473000													31	118					0	0	0.864702	0	0
PCDH20	64881	broad.mit.edu	37	13	61987355	61987355	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:61987355C>A	ENST00000409186.1	-	5	2982	c.877G>T	c.(877-879)Gag>Tag	p.E293*	PCDH20_ENST00000409204.4_Nonsense_Mutation_p.E293*			Q8N6Y1	PCD20_HUMAN	protocadherin 20	266	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CCACCATCCTCAGCTATGATG	0.507000													13	21					7.93312e-07	8.88627e-07	0.457914	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768999	31768999	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:31768999G>T	ENST00000240587.4	-	2	2027	c.1700C>A	c.(1699-1701)tCg>tAg	p.S567*		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	567					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GCTCTTCCCCGACGAGCCCAG	0.587000													37	89					1.52319e-26	2.38514e-26	0.840704	1	0
PRSS55	203074	broad.mit.edu	37	8	10388829	10388829	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:10388829G>T	ENST00000328655.3	+	3	412	c.372G>T	c.(370-372)ctG>ctT	p.L124L	PRSS51_ENST00000523024.1_RNA|PRSS55_ENST00000522210.1_Silent_p.L124L	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	124	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						GTGTCGTGCTGGGGACCAACG	0.507000													44	135					2.43139e-17	3.39499e-17	0.870114	1	0
ADIPOR1	51094	broad.mit.edu	37	1	202911196	202911196	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:202911196G>A	ENST00000340990.5	-	7	1254	c.956C>T	c.(955-957)gCt>gTt	p.A319V	ADIPOR1_ENST00000436244.1_Missense_Mutation_p.A319V	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	319					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			AGGAATTCGAGCAGCATAAAG	0.493000													50	61					0	0	0.870114	0	0
HTR3E	285242	broad.mit.edu	37	3	183824006	183824006	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:183824006A>T	ENST00000415389.2	+	8	1482	c.1016A>T	c.(1015-1017)cAg>cTg	p.Q339L	HTR3E_ENST00000425359.2_Missense_Mutation_p.Q324L|HTR3E_ENST00000335304.2_Missense_Mutation_p.Q354L|HTR3E_ENST00000436361.2_Missense_Mutation_p.Q339L|HTR3E_ENST00000440596.2_Missense_Mutation_p.Q365L	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	339						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			GCCACCACCCAGCCCCCACCC	0.652000													50	81					0	0	0.870114	0	0
CYFIP1	23191	broad.mit.edu	37	15	22939184	22939184	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:22939184G>T	ENST00000313077.7	+	10	1035	c.910G>T	c.(910-912)Gtg>Ttg	p.V304L	CYFIP1_ENST00000560848.1_Missense_Mutation_p.V304L	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	304					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GCAACTCCAGGTGGTTCCGCT	0.388000													53	95					1.10103e-14	1.46966e-14	0.870114	1	0
OR6X1	390260	broad.mit.edu	37	11	123624358	123624358	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:123624358A>G	ENST00000327930.2	-	1	895	c.869T>C	c.(868-870)aTt>aCt	p.I290T		NM_001005188.1	NP_001005188.1	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X, member 1	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)	23		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CTTGTTTCTAATAGTATAAAT	0.413000													10	67					0	0	0.411799	0	0
WNK3	65267	broad.mit.edu	37	X	54275344	54275344	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:54275344G>A	ENST00000354646.2	-	17	3875	c.3437C>T	c.(3436-3438)tCt>tTt	p.S1146F	WNK3_ENST00000375159.2_Missense_Mutation_p.S1146F|WNK3_ENST00000375169.3_Missense_Mutation_p.S1146F	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1146					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						AGCAGAGGAAGAAAATGGAGA	0.438000													109	8					0	0	0.870114	0	0
ZNF83	55769	broad.mit.edu	37	19	53116752	53116752	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:53116752G>T	ENST00000597597.1	-	2	3319	c.1066C>A	c.(1066-1068)Cgc>Agc	p.R356S	ZNF83_ENST00000536937.1_Missense_Mutation_p.R356S|ZNF83_ENST00000541777.2_Missense_Mutation_p.R356S|ZNF83_ENST00000601257.1_Intron|ZNF83_ENST00000391789.4_Missense_Mutation_p.R328S|ZNF83_ENST00000301096.3_Missense_Mutation_p.R356S|ZNF83_ENST00000600714.1_Intron|ZNF83_ENST00000544146.1_Missense_Mutation_p.R356S|ZNF83_ENST00000545872.1_Missense_Mutation_p.R356S			P51522	ZNF83_HUMAN	zinc finger protein 83	356						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		TATGAATTGCGACTGAAGACC	0.408000													48	65					9.57592e-29	1.55995e-28	0.870114	1	0
RC3H1	149041	broad.mit.edu	37	1	173931080	173931080	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:173931080T>A	ENST00000367696.2	-	12	2336	c.1985A>T	c.(1984-1986)tAc>tTc	p.Y662F	RC3H1_ENST00000367694.2_Missense_Mutation_p.Y662F|RC3H1_ENST00000258349.4_Missense_Mutation_p.Y662F			Q5TC82	RC3H1_HUMAN	ring finger and CCCH-type domains 1	662	Pro-rich.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	50						TATAGGTGGGTACTGCTGTGG	0.498000													72	108					0	0	0.870114	0	0
POLD2	5425	broad.mit.edu	37	7	44156479	44156479	+	Silent	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:44156479G>C	ENST00000406581.2	-	7	1366	c.717C>G	c.(715-717)tcC>tcG	p.S239S	POLD2_ENST00000223361.3_Silent_p.S239S|POLD2_ENST00000452185.1_Silent_p.S239S	NM_001256879.1	NP_001243808.1	P49005	DPOD2_HUMAN	polymerase (DNA directed), delta 2, accessory subunit	239					base-excision repair|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	DNA binding|DNA-directed DNA polymerase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	12						GGATAACCCGGGAGACGTGGG	0.652000													16	45					0	0	0.557998	0	0
SEMA4A	64218	broad.mit.edu	37	1	156146213	156146213	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:156146213G>C	ENST00000368285.3	+	15	1978	c.1711G>C	c.(1711-1713)Gtc>Ctc	p.V571L	SEMA4A_ENST00000368284.1_Missense_Mutation_p.V439L|SEMA4A_ENST00000355014.2_Missense_Mutation_p.V571L|SEMA4A_ENST00000368282.1_Missense_Mutation_p.V571L|SEMA4A_ENST00000368286.2_Missense_Mutation_p.V439L	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	571					axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					AGTCCTGGCTGTCCCCAACTC	0.527000													22	43					0	0	0.681144	0	0
OPN5	221391	broad.mit.edu	37	6	47763178	47763178	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:47763178C>A	ENST00000489301.2	+	4	720	c.635C>A	c.(634-636)aCg>aAg	p.T212K	OPN5_ENST00000371211.2_Missense_Mutation_p.T212K|OPN5_ENST00000244799.4_3'UTR|OPN5_ENST00000393699.2_Missense_Mutation_p.T212K			Q6U736	OPN5_HUMAN	opsin 5	212					phototransduction|protein-chromophore linkage|visual perception	integral to membrane	G-protein coupled receptor activity|photoreceptor activity			endometrium(1)|large_intestine(3)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	29						TTGCTCCCAACGGCTGTGATC	0.537000													32	93					2.20474e-14	2.93642e-14	0.788014	1	0
PENK	5179	broad.mit.edu	37	8	57358302	57358302	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:57358302G>A	ENST00000518770.1	-	3	364	c.211C>T	c.(211-213)Cgg>Tgg	p.R71W	PENK_ENST00000451791.2_Intron|PENK_ENST00000314922.3_Intron|PENK_ENST00000523051.1_Intron			P01210	PENK_HUMAN	proenkephalin	130					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GCGGTGGGCCGGAGGCAGTCC	0.672000													18	84					0	0	0.539581	0	0
ALPK1	80216	broad.mit.edu	37	4	113333137	113333137	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:113333137C>G	ENST00000458497.1	+	5	710	c.431C>G	c.(430-432)gCc>gGc	p.A144G	ALPK1_ENST00000177648.9_Missense_Mutation_p.A144G|ALPK1_ENST00000504176.2_Missense_Mutation_p.A66G|ALPK1_ENST00000505912.1_3'UTR	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	144							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		ACGCCAATTGCCCCGCAGGTG	0.602000													27	62					0	0	0.796494	0	0
KDM4D	55693	broad.mit.edu	37	11	94731474	94731474	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:94731474G>T	ENST00000335080.5	+	3	1770	c.938G>T	c.(937-939)gGg>gTg	p.G313V	KDM4D_ENST00000536741.1_Missense_Mutation_p.G313V	NM_018039.2	NP_060509.2	Q6B0I6	KDM4D_HUMAN	lysine (K)-specific demethylase 4D	313					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(16)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TGTAGCTGTGGGGAGGCAAGG	0.547000													18	28					8.00594e-06	8.78913e-06	0.557998	1	0
PCDHB17P	54661	broad.mit.edu	37	5	140536977	140536977	+	Silent	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:140536977C>G	ENST00000539533.1	+	1	1401	c.1401C>G	c.(1399-1401)ccC>ccG	p.P467P																								ACAACAGCCCCGCCCTGCACA	0.637000													60	138					0	0	0.870114	0	0
SLC10A2	6555	broad.mit.edu	37	13	103703661	103703661	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:103703661G>T	ENST00000245312.3	-	4	1303	c.707C>A	c.(706-708)gCg>gAg	p.A236E		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	236					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGAGTAACCCGCCACAGGAAA	0.433000													96	30					4.46965e-45	7.94312e-45	0.870114	1	0
C1orf85	112770	broad.mit.edu	37	1	156264222	156264222	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:156264222G>A	ENST00000362007.1	-	3	539	c.513C>T	c.(511-513)gcC>gcT	p.A171A	C1orf85_ENST00000472870.1_Intron|C1orf85_ENST00000368264.1_Silent_p.A85A	NM_001256604.1|NM_001256609.1|NM_144580.2	NP_001243533.1|NP_001243538.1|NP_653181.1	Q8WWB7	NCUG1_HUMAN	chromosome 1 open reading frame 85	171					positive regulation of transcription from RNA polymerase II promoter	cytosol|integral to membrane|lysosomal membrane|nucleus	ligand-dependent nuclear receptor activity|protein binding transcription factor activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(2)|prostate(2)|skin(3)	14	Hepatocellular(266;0.158)					CTTGAAATGTGGCACTCAGGG	0.517000													21	105					0	0	0.654019	0	0
LRFN2	57497	broad.mit.edu	37	6	40399890	40399890	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:40399890G>T	ENST00000338305.6	-	2	1505	c.963C>A	c.(961-963)caC>caA	p.H321Q		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	321	Ig-like.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGGCTACCCAGTGGATAAGGG	0.592000													15	42					8.00594e-06	8.78913e-06	0.557998	1	0
MUC16	94025	broad.mit.edu	37	19	9075689	9075689	+	Silent	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:9075689A>C	ENST00000397910.4	-	3	11960	c.11757T>G	c.(11755-11757)acT>acG	p.T3919T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3920	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTGGGGATGAAGTCGTCCCAG	0.463000													9	7					0	0	0.361761	0	0
DNHD1	144132	broad.mit.edu	37	11	6588453	6588453	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:6588453G>T	ENST00000254579.6	+	36	12278	c.11714G>T	c.(11713-11715)aGc>aTc	p.S3905I	DNHD1_ENST00000527990.2_Missense_Mutation_p.S3905I	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	3905					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GACCTGGCCAGCCATCTACTG	0.582000													38	120					2.35958e-20	3.46225e-20	0.847076	1	0
SPTBN1	6711	broad.mit.edu	37	2	54858111	54858111	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:54858111A>G	ENST00000333896.5	+	15	3273	c.2888A>G	c.(2887-2889)aAg>aGg	p.K963R	SPTBN1_ENST00000356805.4_Missense_Mutation_p.K976R	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	976					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			GAAAAGACCAAGGTCATCGAG	0.582000													30	21					0	0	0.769981	0	0
PLXNA2	5362	broad.mit.edu	37	1	208390472	208390472	+	Missense_Mutation	SNP	C	C	A	rs138081202		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:208390472C>A	ENST00000367033.3	-	2	1553	c.796G>T	c.(796-798)Gtg>Ttg	p.V266L		NM_025179.3	NP_079455.3	O75051	PLXA2_HUMAN	plexin A2	266	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		TTGATGGCCACACCCTCAGGG	0.577000													32	160					5.71845e-15	7.66677e-15	0.812448	1	0
MIDN	90007	broad.mit.edu	37	19	1255633	1255633	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:1255633G>T	ENST00000300952.2	+	7	1584	c.1069G>T	c.(1069-1071)Gct>Tct	p.A357S	MIDN_ENST00000591446.2_Missense_Mutation_p.A357S	NM_177401.4	NP_796375.3	Q504T8	MIDN_HUMAN	midnolin	357						nucleolus				NS(1)|endometrium(3)|kidney(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGCTCACGGCTGCCCCCTC	0.736000													10	18					0.000219431	0.000232069	0.457914	1	0
TCF21	6943	broad.mit.edu	37	6	134210643	134210643	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:134210643G>T	ENST00000367882.4	+	1	368	c.108G>T	c.(106-108)gaG>gaT	p.E36D	RP3-323P13.2_ENST00000607573.1_RNA|TCF21_ENST00000237316.3_Missense_Mutation_p.E36D	NM_003206.3	NP_003197.2	O43680	TCF21_HUMAN	transcription factor 21	36					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	13	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		CTTCCAACGAGAGCACCGAGG	0.587000													32	33					1.06801e-11	1.33999e-11	0.740014	1	0
LILRA3	11026	broad.mit.edu	37	19	54803067	54803067	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:54803067C>A	ENST00000391745.1	-	8	977	c.661G>T	c.(661-663)Gct>Tct	p.A221S	LILRA3_ENST00000251390.3_Missense_Mutation_p.A204S|LILRA3_ENST00000391744.3_Intron					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACATAGGGAGCGCGCGAGTCA	0.607000													36	44					3.05275e-18	4.36312e-18	0.864702	1	0
CETP	1071	broad.mit.edu	37	16	57003901	57003901	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:57003901A>G	ENST00000200676.3	+	5	645	c.515A>G	c.(514-516)cAa>cGa	p.Q172R	CETP_ENST00000379780.2_Missense_Mutation_p.Q172R|CETP_ENST00000569082.1_3'UTR|CETP_ENST00000566128.1_Missense_Mutation_p.Q107R	NM_000078.2	NP_000069.2	P11597	CETP_HUMAN	cholesteryl ester transfer protein, plasma	172					cholesterol homeostasis|cholesterol metabolic process|high-density lipoprotein particle remodeling|lipoprotein metabolic process|low-density lipoprotein particle remodeling|phosphatidylcholine metabolic process|phospholipid homeostasis|receptor-mediated endocytosis|regulation of cholesterol efflux|triglyceride homeostasis|triglyceride metabolic process|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle|vesicle	cholesterol binding|cholesterol transporter activity|phosphatidylcholine binding|phospholipid transporter activity|triglyceride binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(4)|skin(3)	23						CTGCATCTCCAAGGGGAGCGA	0.597000													18	29					0	0	0.592651	0	0
PRTG	283659	broad.mit.edu	37	15	55970154	55970154	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:55970154C>T	ENST00000389286.4	-	8	1269	c.1222G>A	c.(1222-1224)Gcc>Acc	p.A408T		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	408	Ig-like 4.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		GTCAGTCTGGCTCTAGATAAA	0.413000													23	26					0	0	0.681144	0	0
MUC17	140453	broad.mit.edu	37	7	100677758	100677758	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:100677758A>G	ENST00000306151.4	+	3	3125	c.3061A>G	c.(3061-3063)Agt>Ggt	p.S1021G		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1021	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TACTGAAGCCAGTTCACCTCC	0.522000													154	872					0	0	0.870114	0	0
ANKS1B	56899	broad.mit.edu	37	12	100048923	100048923	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:100048923C>A	ENST00000547776.2	-	9	1193	c.1194G>T	c.(1192-1194)acG>acT	p.T398T	ANKS1B_ENST00000329257.7_Silent_p.T398T|ANKS1B_ENST00000547010.1_5'UTR	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	398						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ATGGCCCACACGTATTTTCAT	0.383000													7	27					1.58986e-06	1.7776e-06	0.361761	1	0
LILRA2	11027	broad.mit.edu	37	19	55086784	55086784	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:55086784C>G	ENST00000251377.3	+	6	850	c.717C>G	c.(715-717)agC>agG	p.S239R	LILRA2_ENST00000391738.3_Missense_Mutation_p.S239R|LILRA2_ENST00000391737.1_Missense_Mutation_p.S227R|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.S239R|LILRB1_ENST00000396321.2_Intron|LILRB1_ENST00000448689.1_Intron					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CCGGGGAGAGCCTGACCCTCC	0.577000													34	48					0	0	0.796494	0	0
DPP6	1804	broad.mit.edu	37	7	154263993	154263993	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:154263993G>T	ENST00000404039.1	+	5	1014	c.427G>T	c.(427-429)Gtg>Ttg	p.V143L	DPP6_ENST00000427557.1_Missense_Mutation_p.V145L|DPP6_ENST00000406326.1_Missense_Mutation_p.V207L|DPP6_ENST00000496611.1_3'UTR|DPP6_ENST00000377770.3_Missense_Mutation_p.V207L|DPP6_ENST00000332007.3_Missense_Mutation_p.V145L	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	207					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TTCATACAATGTGGAACCCGT	0.294000													3	31					0.150653	0.152925	0.150653	1	0
POU4F2	5458	broad.mit.edu	37	4	147561660	147561660	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:147561660T>C	ENST00000281321.3	+	2	1178	c.930T>C	c.(928-930)aaT>aaC	p.N310N		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	310	POU-specific.				estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					TGTCCCACAATAATATGATCG	0.607000													39	59					0	0	0.870114	0	0
LAMA2	3908	broad.mit.edu	37	6	129618872	129618872	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:129618872T>A	ENST00000421865.2	+	21	2948	c.2899T>A	c.(2899-2901)Tgc>Agc	p.C967S		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	967	Laminin EGF-like 10.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTGTGTTCCCTGCAACTGCAA	0.468000													28	8					0	0	0.769981	0	0
DCDC1	341019	broad.mit.edu	37	11	31086605	31086605	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:31086605G>T	ENST00000597505.1	-	17	2393	c.2394C>A	c.(2392-2394)acC>acA	p.T798T	DCDC1_ENST00000437348.1_5'UTR			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GATGAGCTGTGGTCCAGGCAC	0.443000													22	39					3.01185e-09	3.53717e-09	0.667858	1	0
CRX	1406	broad.mit.edu	37	19	48342786	48342786	+	Silent	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:48342786C>G	ENST00000221996.7	+	4	668	c.462C>G	c.(460-462)acC>acG	p.T154T	CRX_ENST00000539067.1_Silent_p.T154T|TPRX2P_ENST00000535362.1_Intron	NM_000554.4	NP_000545.1	O43186	CRX_HUMAN	cone-rod homeobox	154					organ morphogenesis|response to stimulus|visual perception		leucine zipper domain binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|urinary_tract(1)	23		all_cancers(25;2.76e-09)|all_epithelial(76;7.01e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000266)|all cancers(93;0.000788)|Epithelial(262;0.0226)|GBM - Glioblastoma multiforme(486;0.0521)		GCTCCCCAACCACGGCAGTGG	0.667000													34	55					0	0	0.853193	0	0
DIS3	22894	broad.mit.edu	37	13	73348154	73348154	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:73348154C>A	ENST00000377767.4	-	7	1131	c.1031G>T	c.(1030-1032)aGa>aTa	p.R344I	DIS3_ENST00000377780.4_Missense_Mutation_p.R314I|DIS3_ENST00000545453.1_Missense_Mutation_p.R182I	NM_014953.3	NP_055768.3	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)	344					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding	p.R344T(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(7)|kidney(5)|large_intestine(10)|lung(6)|prostate(2)|skin(1)	35		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TCCTACAACTCTACCTGTAGG	0.333000										Multiple Myeloma(4;0.011)			15	34					3.62473e-10	4.38441e-10	0.608945	1	0
PSD3	23362	broad.mit.edu	37	8	18729545	18729545	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:18729545C>A	ENST00000440756.2	-	3	931	c.829G>T	c.(829-831)Ggg>Tgg	p.G277W	PSD3_ENST00000523619.1_Missense_Mutation_p.G212W|PSD3_ENST00000327040.8_Missense_Mutation_p.G277W			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	277					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		TGCTCTCTCCCAAGAGCAGAC	0.572000													17	43					6.49762e-13	8.39564e-13	0.539581	1	0
NLRP6	171389	broad.mit.edu	37	11	281566	281566	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:281566A>G	ENST00000534750.1	+	4	2037	c.1832A>G	c.(1831-1833)gAg>gGg	p.E611G	NLRP6_ENST00000312165.5_Missense_Mutation_p.E611G	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		GAGGAGGAGGAGGGAGAGGAG	0.662000													7	147					0	0	0.411799	0	0
CDH18	1016	broad.mit.edu	37	5	19838969	19838969	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:19838969C>A	ENST00000507958.1	-	5	1117	c.127G>T	c.(127-129)Ggt>Tgt	p.G43C	CDH18_ENST00000382275.1_Missense_Mutation_p.G43C|CDH18_ENST00000506372.1_Missense_Mutation_p.G43C|CDH18_ENST00000502796.1_Missense_Mutation_p.G43C|CDH18_ENST00000274170.4_Missense_Mutation_p.G43C|CDH18_ENST00000511273.1_Missense_Mutation_p.G43C			Q13634	CAD18_HUMAN	cadherin 18, type 2	43					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TCGGTTTCACCTTCAATGTGT	0.448000													20	150					1.96895e-08	2.27707e-08	0.639603	1	0
PSD4	23550	broad.mit.edu	37	2	113940672	113940672	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:113940672A>C	ENST00000245796.6	+	2	834	c.639A>C	c.(637-639)gaA>gaC	p.E213D	PSD4_ENST00000441564.2_Missense_Mutation_p.E213D	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	213					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						ACTCAGGGGAAGACAGCAGTG	0.627000													10	27					0	0	0.411799	0	0
ADAM23	8745	broad.mit.edu	37	2	207310211	207310211	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:207310211T>C	ENST00000264377.3	+	2	723	c.395T>C	c.(394-396)cTt>cCt	p.L132P	ADAM23_ENST00000374415.3_Missense_Mutation_p.L132P|ADAM23_ENST00000374416.1_Missense_Mutation_p.L132P	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	132					cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TATCACGTTCTTGACACAAAG	0.383000													49	120					0	0	0.870114	0	0
TTLL7	79739	broad.mit.edu	37	1	84417870	84417870	+	Splice_Site	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:84417870C>A	ENST00000260505.8	-	2	402	c.25_splice	c.e2+1	p.V9_splice	TTLL7_ENST00000477524.1_5'UTR	NM_024686.4	NP_078962.4	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	9					cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			kidney(1)|large_intestine(8)|lung(15)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ATTTCCCTACCTCCTTCTTGA	0.353000													51	47					2.34191e-24	3.6204e-24	0.870114	1	0
GABRA6	2559	broad.mit.edu	37	5	161128659	161128659	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:161128659C>A	ENST00000523217.1	+	9	1454	c.1212C>A	c.(1210-1212)acC>acA	p.T404T	GABRA6_ENST00000274545.5_Silent_p.T414T	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	414			P -> S (in dbSNP:rs34907804).		gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TTGGAGGCACCAGTAAAATAG	0.463000										TCGA Ovarian(5;0.080)			19	37					1.96895e-08	2.27707e-08	0.639603	1	0
SRPX	8406	broad.mit.edu	37	X	38080662	38080662	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:38080662C>T	ENST00000343800.6	-	1	34	c.35G>A	c.(34-36)aGt>aAt	p.S12N	TM4SF2_ENST00000465127.1_Intron|RP13-43E11.1_ENST00000423919.1_RNA			P78539	SRPX_HUMAN	sushi-repeat containing protein, X-linked	0					cell adhesion	cell surface|membrane				autonomic_ganglia(1)|breast(2)|endometrium(5)|large_intestine(5)|lung(10)|prostate(2)	25						gggactggaacttaggtgtgt	0.463000											OREG0019726	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	6					0	0	0.387290	0	0
PDHA2	5161	broad.mit.edu	37	4	96762441	96762441	+	Silent	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:96762441A>T	ENST00000295266.4	+	1	1203	c.1140A>T	c.(1138-1140)ccA>ccT	p.P380P		NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2	380					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GTGCAAATCCATGGATCAAGT	0.418000													23	52					0	0	0.740014	0	0
OR8B3	390271	broad.mit.edu	37	11	124267042	124267042	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:124267042A>T	ENST00000354597.3	-	1	222	c.206T>A	c.(205-207)aTt>aAt	p.I69N		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		ACAGAGATCAATGAAGGAGAG	0.388000													7	58					0	0	0.248553	0	0
FAM179A	165186	broad.mit.edu	37	2	29247039	29247039	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:29247039C>A	ENST00000379558.4	+	13	2003	c.1652C>A	c.(1651-1653)gCc>gAc	p.A551D	FAM179A_ENST00000465300.1_3'UTR|FAM179A_ENST00000403861.2_Missense_Mutation_p.A496D	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	551							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TCTCACCTGGCCATCAGCACC	0.612000													10	7					1.36491e-13	1.77497e-13	0.435327	1	0
C2orf71	388939	broad.mit.edu	37	2	29296486	29296486	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:29296486C>A	ENST00000331664.5	-	1	641	c.642G>T	c.(640-642)ctG>ctT	p.L214L		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	214					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TGGGCTGCAGCAGCTCCCGGG	0.547000													26	196					2.68265e-12	3.42972e-12	0.769981	1	0
PSMA7	5688	broad.mit.edu	37	20	60714829	60714829	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:60714829G>A	ENST00000370858.3	-	3	482	c.356C>T	c.(355-357)gCc>gTc	p.A119V	PSMA7_ENST00000370873.4_Intron|PSMA7_ENST00000484488.1_5'UTR|PSMA7_ENST00000370861.1_Intron			O14818	PSA7_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 7	124					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			large_intestine(1)|lung(2)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			AAGCGGGCAGGCACCCACCTG	0.607000													12	51					0	0	0.411799	0	0
HSD3B2	3284	broad.mit.edu	37	1	119958096	119958096	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:119958096C>A	ENST00000543831.1	+	2	303	c.54C>A	c.(52-54)atC>atA	p.I18I	HSD3B2_ENST00000369416.3_Silent_p.I18I|HSD3B2_ENST00000471656.1_3'UTR	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	18					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	GTCAGAGGATCGTCCGCCTGT	0.512000													39	40					4.14481e-20	6.06704e-20	0.819951	1	0
NAV2	89797	broad.mit.edu	37	11	20136343	20136343	+	Splice_Site	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:20136343T>G	ENST00000396085.1	+	38	7534		c.e38+2		NAV2_ENST00000540292.1_Splice_Site|NAV2_ENST00000533917.1_Splice_Site|NAV2_ENST00000527559.2_Splice_Site|NAV2_ENST00000396087.3_Splice_Site|NAV2_ENST00000311043.8_Splice_Site|NAV2_ENST00000360655.4_Splice_Site|NAV2_ENST00000349880.4_Splice_Site	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2							nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						GACCCGCTGGTGAGTCCTCAG	0.552000													9	24					0	0	0.411799	0	0
ZC3H4	23211	broad.mit.edu	37	19	47589764	47589764	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:47589764G>T	ENST00000253048.5	-	6	784	c.747C>A	c.(745-747)ggC>ggA	p.G249G	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	249	Gly-rich.						nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGCTTCCTCGGCCCCTGTAGC	0.662000													11	25					1.36491e-13	1.77497e-13	0.435327	1	0
SLC25A40	55972	broad.mit.edu	37	7	87473179	87473179	+	Splice_Site	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:87473179C>A	ENST00000341119.5	-	9	978		c.e9-1			NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					CAGTACATTGCTATAAAAACA	0.289000													5	27					0.184627	0.186163	0.184627	1	0
IGHV3-53	28420	broad.mit.edu	37	14	107048679	107048679	+	RNA	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:107048679C>A	ENST00000390627.2	-	0	561																											GTCTCTCGCACAGTAATACAC	0.572000													37	90					1.10255e-20	1.62566e-20	0.870114	1	0
PHEX	5251	broad.mit.edu	37	X	22108604	22108604	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:22108604G>T	ENST00000379374.4	+	6	1286	c.721G>T	c.(721-723)Gaa>Taa	p.E241*	PHEX_ENST00000537599.1_Nonsense_Mutation_p.E241*|PHEX_ENST00000535894.1_Nonsense_Mutation_p.E144*	NM_000444.4	NP_000435.3	P78562	PHEX_HUMAN	phosphate regulating endopeptidase homolog, X-linked	241					biomineral tissue development|cell-cell signaling|protein modification process|proteolysis|skeletal system development	integral to plasma membrane	aminopeptidase activity|metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(2)|endometrium(2)|large_intestine(12)|liver(1)|lung(19)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	42						TAACAGTACAGAAGCCAAGTC	0.438000													19	5					2.39556e-15	3.23321e-15	0.639603	1	0
CUL2	8453	broad.mit.edu	37	10	35300818	35300818	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:35300818C>A	ENST00000374748.1	-	21	2377	c.2064G>T	c.(2062-2064)atG>atT	p.M688I	CUL2_ENST00000374742.1_Intron|CUL2_ENST00000374746.1_Intron|CUL2_ENST00000374751.3_Missense_Mutation_p.M688I|CUL2_ENST00000374749.3_Missense_Mutation_p.M688I|CUL2_ENST00000537177.1_Missense_Mutation_p.M707I|CUL2_ENST00000602371.1_Missense_Mutation_p.M631I			Q13617	CUL2_HUMAN	cullin 2	688					cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|prostate(2)|skin(1)|urinary_tract(2)	31						TTCGTGCTTTCATGATACGAA	0.438000													4	19					0.00909568	0.00937412	0.150653	1	0
TRIM48	79097	broad.mit.edu	37	11	55032777	55032777	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:55032777C>A	ENST00000417545.2	+	2	532	c.446C>A	c.(445-447)gCt>gAt	p.A149D		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	133						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GAGTGGGCTGCTGAGGAACAC	0.493000													41	47					3.73646e-36	6.41443e-36	0.870114	1	0
IGKV3D-20	28874	broad.mit.edu	37	2	90078019	90078019	+	RNA	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:90078019C>A	ENST00000390270.2	+	0	153																											TCAGATACCACCGGAGAAATT	0.473000													60	48					1.55545e-33	2.61833e-33	0.870114	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84607144	84607144	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:84607144C>A	ENST00000344803.2	+	4	1806	c.1759C>A	c.(1759-1761)Cca>Aca	p.P587T		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		ACCTCAATCTCCATTCCGAGC	0.527000													19	52					0.00229938	0.002386	0.624587	1	0
RMI1	80010	broad.mit.edu	37	9	86616177	86616177	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:86616177G>A	ENST00000325875.3	+	3	608	c.276G>A	c.(274-276)ttG>ttA	p.L92L		NM_024945.2	NP_079221.2	Q9H9A7	RMI1_HUMAN	RecQ mediated genome instability 1	92					DNA replication	nucleus				biliary_tract(1)|central_nervous_system(1)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18						TTAATTCCTTGGTTGATGTAA	0.393000													29	42					0	0	0.760397	0	0
FAM209B	388799	broad.mit.edu	37	20	55108546	55108546	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:55108546A>T	ENST00000371325.1	+	1	245	c.149A>T	c.(148-150)gAg>gTg	p.E50V		NM_001013646.2	NP_001013668.2	Q5JX69	CT107_HUMAN	family with sequence similarity 209, member B	50						integral to membrane											AACCTACCAGAGCACACCCAA	0.502000													51	82					0	0	0.870114	0	0
NKX6-2	84504	broad.mit.edu	37	10	134598456	134598456	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:134598456G>T	ENST00000368592.5	-	3	901	c.798C>A	c.(796-798)gtC>gtA	p.V266V		NM_177400.2	NP_796374.1	Q9C056	NKX62_HUMAN	NK6 homeobox 2	266						nucleus	sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(2)	3		all_cancers(35;2.79e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0584)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;4.06e-05)|Epithelial(32;5.53e-05)|all cancers(32;5.99e-05)		CGCACGGGCTGACCAGCGCCA	0.677000													10	16					0.0167234	0.0171769	0.435327	1	0
FPGT	8790	broad.mit.edu	37	1	74670341	74670341	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:74670341G>T	ENST00000370898.2	+	4	647	c.610G>T	c.(610-612)Gga>Tga	p.G204*	FPGT-TNNI3K_ENST00000370895.1_Intron|FPGT_ENST00000370894.4_Intron|TNNI3K_ENST00000370891.2_Intron|FPGT_ENST00000524915.1_Intron|FPGT_ENST00000534056.1_Intron|TNNI3K_ENST00000370893.1_Intron|FPGT-TNNI3K_ENST00000370899.3_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						TACCACACATGGAGTATTTGT	0.363000													40	23					5.13769e-22	7.72565e-22	0.870114	1	0
PHKG1	5260	broad.mit.edu	37	7	56156616	56156616	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:56156616G>T	ENST00000537360.1	-	0	168				PHKG1_ENST00000452681.2_Missense_Mutation_p.L7M|PHKG1_ENST00000297373.2_Missense_Mutation_p.L7M|PHKG1_ENST00000489604.1_5'UTR			Q16816	PHKG1_HUMAN	phosphorylase kinase, gamma 1 (muscle)						glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			endometrium(1)|large_intestine(1)|lung(5)	7	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			GAGTCCGGCAGTGCCTCGTCC	0.547000													16	17					1.28384e-07	1.47071e-07	0.608945	1	0
ZNF883	169834	broad.mit.edu	37	9	115760149	115760149	+	RNA	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:115760149C>T	ENST00000427548.1	-	0	1664							P0CG24	ZN883_HUMAN	zinc finger protein 883						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										AAAGCTTTCCCACATTCATTA	0.378000													11	12					0	0	0.500413	0	0
USH2A	7399	broad.mit.edu	37	1	216380628	216380628	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:216380628A>C	ENST00000366943.2	-	16	3689	c.3303T>G	c.(3301-3303)gaT>gaG	p.D1101E	USH2A_ENST00000366942.3_Missense_Mutation_p.D1101E|USH2A_ENST00000307340.3_Missense_Mutation_p.D1101E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1101	Fibronectin type-III 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATGGGTATTGATCCTCTGTTG	0.378000										HNSCC(13;0.011)			18	87					0	0	0.539581	0	0
TG	7038	broad.mit.edu	37	8	133913625	133913625	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:133913625G>A	ENST00000220616.4	+	16	3501	c.3461G>A	c.(3460-3462)aGt>aAt	p.S1154N	TG_ENST00000377869.1_Missense_Mutation_p.S1154N	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1154	Thyroglobulin type-1 10.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTGCTCAAGAGTGGAGTCCTC	0.612000													45	212					0	0	0.870114	0	0
OR2L2	26246	broad.mit.edu	37	1	248202414	248202414	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:248202414C>A	ENST00000366479.2	+	1	941	c.845C>A	c.(844-846)cCa>cAa	p.P282Q	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	282					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			ATCCTCACCCCAATGCTCAAC	0.463000													26	137					6.00712e-18	8.48559e-18	0.760397	1	0
CRISPLD2	83716	broad.mit.edu	37	16	84884260	84884260	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:84884260G>T	ENST00000262424.5	+	5	803	c.579G>T	c.(577-579)gcG>gcT	p.A193A	CRISPLD2_ENST00000567845.1_Silent_p.A193A|CRISPLD2_ENST00000566431.1_3'UTR|CRISPLD2_ENST00000564567.1_Silent_p.A193A	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	193						extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						GGGAGAACGCGGTCTACTTTG	0.502000													32	100					1.04352e-10	1.2827e-10	0.788014	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146829410	146829410	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:146829410T>A	ENST00000361727.3	+	8	1673	c.1157T>A	c.(1156-1158)gTg>gAg	p.V386E		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	386					behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TACCTGGAGGTGCCCGGACGG	0.473000										HNSCC(39;0.1)			20	68					0	0	0.639603	0	0
APOBEC3D	140564	broad.mit.edu	37	22	39428305	39428305	+	Missense_Mutation	SNP	G	G	T	rs149444818	by1000genomes	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr22:39428305G>T	ENST00000216099.7	+	7	1552	c.1145G>T	c.(1144-1146)cGg>cTg	p.R382L	APOBEC3D_ENST00000427494.2_Missense_Mutation_p.R198L|APOBEC3D_ENST00000381568.4_Missense_Mutation_p.R382L	NM_152426.3	NP_689639.2	Q96AK3	ABC3D_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	382					negative regulation of transposition		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)	11	Melanoma(58;0.04)					AGAAGGCTACGGGAGATTCTC	0.512000													50	66					1.08141e-31	1.80036e-31	0.870114	1	0
EMILIN2	84034	broad.mit.edu	37	18	2890834	2890834	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:2890834A>T	ENST00000254528.3	+	4	868	c.709A>T	c.(709-711)Acc>Tcc	p.T237S		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	237					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		CAAGCCTGACACCACTGTTAG	0.517000													51	52					0	0	0.870114	0	0
TSHZ3	57616	broad.mit.edu	37	19	31768654	31768654	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:31768654C>A	ENST00000240587.4	-	2	2372	c.2045G>T	c.(2044-2046)aGc>aTc	p.S682I		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	682					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					AGCGAGGGGGCTCCCATCCTT	0.652000													12	94					1.5842e-08	1.83913e-08	0.435327	1	0
VIP	7432	broad.mit.edu	37	6	153078256	153078256	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:153078256C>A	ENST00000367244.3	+	6	665	c.493C>A	c.(493-495)Cca>Aca	p.P165T	VIP_ENST00000367243.3_Missense_Mutation_p.P164T	NM_003381.3	NP_003372.1	P01282	VIP_HUMAN	vasoactive intestinal peptide	165					body fluid secretion|G-protein coupled receptor protein signaling pathway|positive regulation of cell proliferation	extracellular region	neuropeptide hormone activity			haematopoietic_and_lymphoid_tissue(1)|lung(4)|skin(1)	6		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;4.5e-11)|BRCA - Breast invasive adenocarcinoma(81;0.144)		TCCCGACTTTCCAGAAGAGTT	0.398000													21	9					2.24059e-21	3.34434e-21	0.706142	1	0
NBEAL2	23218	broad.mit.edu	37	3	47037928	47037928	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:47037928G>T	ENST00000450053.3	+	16	2498	c.2319G>T	c.(2317-2319)gtG>gtT	p.V773V	NBEAL2_ENST00000292309.5_Silent_p.V773V|NBEAL2_ENST00000383740.2_5'UTR	NM_015175.2	NP_055990.1	Q6ZNJ1	NBEL2_HUMAN	neurobeachin-like 2	773							binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(9)|lung(9)|ovary(4)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Acute lymphoblastic leukemia(5;0.0534)		BRCA - Breast invasive adenocarcinoma(193;0.0012)|KIRC - Kidney renal clear cell carcinoma(197;0.00575)|Kidney(197;0.00656)		CCGGGCTGGTGGCCCCCCTGC	0.716000													20	0					3.99206e-14	5.2591e-14	0.557998	1	0
RASGRP3	25780	broad.mit.edu	37	2	33749040	33749040	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:33749040G>T	ENST00000403687.3	+	8	1351	c.611G>T	c.(610-612)tGg>tTg	p.W204L	RASGRP3_ENST00000407811.1_Missense_Mutation_p.W204L|RASGRP3_ENST00000402538.3_Missense_Mutation_p.W204L	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	204	Ras-GEF.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity	p.W204L(1)		large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					ATCTCTAAGTGGGTCCAGTTG	0.423000													55	237					6.3091e-27	9.93069e-27	0.870114	1	0
CEP250	11190	broad.mit.edu	37	20	34091823	34091823	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:34091823G>T	ENST00000397527.1	+	30	6346	c.5626G>T	c.(5626-5628)Gca>Tca	p.A1876S	CEP250_ENST00000342580.4_Missense_Mutation_p.A1820S	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1876	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAAGAGCTGGCAGTGGAGGG	0.617000													21	2					6.44725e-10	7.75205e-10	0.624587	1	0
SLC17A2	10246	broad.mit.edu	37	6	25917231	25917231	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:25917231T>A	ENST00000377850.3	-	7	1258	c.734A>T	c.(733-735)gAa>gTa	p.E245V	SLC17A2_ENST00000265425.3_Missense_Mutation_p.E245V|SLC17A2_ENST00000360488.3_Missense_Mutation_p.E245V			O00624	NPT3_HUMAN	solute carrier family 17, member 2	245					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						GTGCTCCTTTTCCCTAACACT	0.527000													21	67					0	0	0.592651	0	0
SGPP2	130367	broad.mit.edu	37	2	223423135	223423135	+	Missense_Mutation	SNP	G	G	C	rs141548793	by1000genomes	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:223423135G>C	ENST00000321276.7	+	5	804	c.718G>C	c.(718-720)Gac>Cac	p.D240H		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	240					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		GACCTTCATCGACTGCCTGGA	0.537000													4	222					0	0	0.150653	0	0
CASS4	57091	broad.mit.edu	37	20	55027604	55027604	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:55027604C>A	ENST00000371336.3	+	5	1573	c.1372C>A	c.(1372-1374)Ctg>Atg	p.L458M	CASS4_ENST00000434344.1_Intron|CASS4_ENST00000360314.3_Missense_Mutation_p.L458M	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	458					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						TGTCGCTGGCCTGATGCTCTT	0.527000													11	44					0.0135373	0.013928	0.411799	1	0
FAM135B	51059	broad.mit.edu	37	8	139163985	139163985	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:139163985C>A	ENST00000395297.1	-	13	2903	c.2733G>T	c.(2731-2733)ttG>ttT	p.L911F		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	911										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GACCCACATTCAAGTCTTTAG	0.473000										HNSCC(54;0.14)			22	148					3.00307e-07	3.39526e-07	0.729181	1	0
ITK	3702	broad.mit.edu	37	5	156670710	156670710	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:156670710G>T	ENST00000422843.3	+	12	1290	c.1138G>T	c.(1138-1140)Ggc>Tgc	p.G380C	ITK_ENST00000519749.1_3'UTR	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	380	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGCATCTGGGCTACTGGCT	0.498000			T	SYK	peripheral T-cell lymphoma								45	70					1.86277e-20	2.7399e-20	0.870114	1	0
MASP1	5648	broad.mit.edu	37	3	186954176	186954176	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:186954176C>G	ENST00000296280.6	-	11	1708	c.1483G>C	c.(1483-1485)Gca>Cca	p.A495P	MASP1_ENST00000392472.2_Missense_Mutation_p.A382P|MASP1_ENST00000495249.1_Splice_Site|MASP1_ENST00000337774.5_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	488	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		ACATGAGCTGCTGTGAGGATC	0.587000													23	24					0	0	0.681144	0	0
GPC5	2262	broad.mit.edu	37	13	92797109	92797109	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:92797109T>A	ENST00000377067.3	+	7	1800	c.1428T>A	c.(1426-1428)ccT>ccA	p.P476P		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	476						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CACCCAAACCTGACAAGTGGG	0.418000													26	109					0	0	0.769981	0	0
ZNF354C	30832	broad.mit.edu	37	5	178506242	178506242	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:178506242A>C	ENST00000315475.6	+	5	1115	c.809A>C	c.(808-810)aAa>aCa	p.K270T		NM_014594.1	NP_055409.1	Q86Y25	Z354C_HUMAN	zinc finger protein 354C	270					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|urinary_tract(3)	30	all_cancers(89;0.00065)|all_epithelial(37;0.000153)|Renal(175;0.000159)|Lung NSC(126;0.00175)|all_lung(126;0.00309)	all_cancers(40;0.19)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.247)		ACTGGAGAGAAACCTTACAAG	0.398000													27	42					0	0	0.706142	0	0
ZNF519	162655	broad.mit.edu	37	18	14106130	14106130	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:14106130C>T	ENST00000590202.1	-	3	561	c.409G>A	c.(409-411)Gaa>Aaa	p.E137K	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						ATACATGGTTCTGTAGGAGCA	0.279000													6	42					0	0	0.278610	0	0
OR56A3	390083	broad.mit.edu	37	11	5969254	5969254	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:5969254G>T	ENST00000329564.6	+	1	685	c.678G>T	c.(676-678)ctG>ctT	p.L226L		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTTCATTCTGCGAGCTGTGC	0.522000													44	172					2.74695e-27	4.38067e-27	0.870114	1	0
NOS1	4842	broad.mit.edu	37	12	117665347	117665347	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:117665347G>T	ENST00000317775.6	-	23	4190	c.3505C>A	c.(3505-3507)Ctg>Atg	p.L1169M	NOS1_ENST00000338101.4_Missense_Mutation_p.L1203M|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1169	FAD-binding FR-type.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGCTGGGTCAGGAGCAGGGTG	0.582000													125	87					4.4197e-54	8.04307e-54	0.870114	1	0
ANKRD33	341405	broad.mit.edu	37	12	52284917	52284917	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:52284917G>T	ENST00000301190.6	+	5	1414	c.1187G>T	c.(1186-1188)aGg>aTg	p.R396M	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000340970.4_Intron|ANKRD33_ENST00000538991.1_Intron	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		ACCAGCCCCAGGCCCCAAGTC	0.617000													56	41					2.73361e-28	4.40577e-28	0.870114	1	0
SLC25A40	55972	broad.mit.edu	37	7	87473180	87473180	+	Splice_Site	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:87473180T>A	ENST00000341119.5	-	9	978		c.e9-2			NM_018843.3	NP_061331.2	Q8TBP6	S2540_HUMAN	solute carrier family 25, member 40						transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	17	Esophageal squamous(14;0.00202)					AGTACATTGCTATAAAAACAG	0.289000													5	27					0	0	0.217242	0	0
MYO10	4651	broad.mit.edu	37	5	16670930	16670930	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:16670930C>T	ENST00000513610.1	-	39	6042	c.5588G>A	c.(5587-5589)cGc>cAc	p.R1863H	MYO10_ENST00000505695.1_Missense_Mutation_p.R1202H|MYO10_ENST00000274203.9_Missense_Mutation_p.R1220H|MYO10_ENST00000515803.1_Missense_Mutation_p.R1202H|MYO10_ENST00000427430.2_Missense_Mutation_p.R1220H	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1863	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						CTGGCTGATGCGGGCCTTGAG	0.587000													11	98					0	0	0.435327	0	0
PANK1	53354	broad.mit.edu	37	10	91359022	91359022	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:91359022C>G	ENST00000307534.4	-	3	1452	c.1297G>C	c.(1297-1299)Gtt>Ctt	p.V433L	PANK1_ENST00000371774.2_Missense_Mutation_p.V235L|PANK1_ENST00000342512.3_Missense_Mutation_p.V208L|PANK1_ENST00000322191.6_Missense_Mutation_p.V208L	NM_148977.2	NP_683878.1	Q8TE04	PANK1_HUMAN	pantothenate kinase 1	433					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity			cervix(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(2)	11					Bezafibrate(DB01393)	GTCCCTGTAACTCTTTTATAG	0.408000													47	54					0	0	0.870114	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174068	207174068	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:207174068C>T	ENST00000374423.3	+	5	5202	c.4816C>T	c.(4816-4818)Cgg>Tgg	p.R1606W		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1606							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						AATAATAAACCGGAAGAAGGA	0.373000													6	14					0	0	0.248553	0	0
RHPN2	85415	broad.mit.edu	37	19	33490573	33490573	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:33490573G>T	ENST00000254260.3	-	10	1179	c.1144C>A	c.(1144-1146)Ctg>Atg	p.L382M	RHPN2_ENST00000400226.4_Missense_Mutation_p.L231M	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	382	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					AGCTGGGACAGGCACTTCTCC	0.597000													5	76					0.00198382	0.00206208	0.248553	1	0
RAB9B	51209	broad.mit.edu	37	X	103080685	103080685	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:103080685G>A	ENST00000243298.2	-	3	314	c.30C>T	c.(28-30)gtC>gtT	p.V10V		NM_016370.2	NP_057454.1	Q9NP90	RAB9B_HUMAN	RAB9B, member RAS oncogene family	10					Golgi to endosome transport|protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(11)	14						CCAAGAGAATGACCTTTAAGA	0.438000													56	155					0	0	0.870114	0	0
ZNF80	7634	broad.mit.edu	37	3	113955126	113955126	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:113955126T>C	ENST00000482457.2	-	1	1299	c.796A>G	c.(796-798)Atc>Gtc	p.I266V		NM_007136.3	NP_009067.2	P51504	ZNF80_HUMAN	zinc finger protein 80	266						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|urinary_tract(2)	32		Lung NSC(201;0.0233)|all_neural(597;0.0837)				CCAGAGTGGATCTTACTCTGT	0.418000													28	31					0	0	0.788014	0	0
ITGAX	3687	broad.mit.edu	37	16	31382466	31382466	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:31382466G>T	ENST00000268296.4	+	15	1893	c.1772G>T	c.(1771-1773)gGt>gTt	p.G591V	ITGAX_ENST00000562522.1_Missense_Mutation_p.G591V	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	591					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CTGAGCGGGGGTCAAGACCTC	0.632000													9	74					1.414e-09	1.68017e-09	0.788014	1	0
IGHV1-58	28464	broad.mit.edu	37	14	107078541	107078541	+	RNA	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:107078541T>C	ENST00000390628.2	-	0	243																											CAAGGCGTTGTCCACGAGCCT	0.527000													30	9					0	0	0.870114	0	0
RPL10L	140801	broad.mit.edu	37	14	47120935	47120935	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:47120935C>A	ENST00000298283.3	-	1	93	c.5G>T	c.(4-6)gGg>gTg	p.G2V		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	2					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						TGGACGGCGCCCCATGGCGAC	0.562000													49	9					1.21353e-23	1.85708e-23	0.870114	1	0
SCPEP1	59342	broad.mit.edu	37	17	55065061	55065061	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:55065061G>T	ENST00000262288.3	+	4	376	c.321G>T	c.(319-321)caG>caT	p.Q107H	SCPEP1_ENST00000571898.1_3'UTR	NM_021626.2	NP_067639.1	Q9HB40	RISC_HUMAN	serine carboxypeptidase 1	107					proteolysis	extracellular region	serine-type carboxypeptidase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|skin(2)	14	Breast(9;2.86e-08)					CATAGCTCCAGGCTGCCAGTC	0.478000													65	261					6.47592e-44	1.14414e-43	0.870114	1	0
OR6K2	81448	broad.mit.edu	37	1	158669764	158669764	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:158669764G>T	ENST00000359610.2	-	1	722	c.679C>A	c.(679-681)Cta>Ata	p.L227I		NM_001005279.1	NP_001005279.1	Q8NGY2	OR6K2_HUMAN	olfactory receptor, family 6, subfamily K, member 2	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	46	all_hematologic(112;0.0378)					TGAATACGTAGAATTACAGCC	0.453000													32	164					3.62531e-18	5.16926e-18	0.796494	1	0
VNN2	8875	broad.mit.edu	37	6	133077151	133077151	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:133077151G>T	ENST00000326499.6	-	3	492	c.368C>A	c.(367-369)gCa>gAa	p.A123E	VNN2_ENST00000526192.1_5'UTR|VNN2_ENST00000525270.1_Missense_Mutation_p.A70E|VNN2_ENST00000525289.1_Missense_Mutation_p.A123E	NM_004665.2	NP_004656.2	O95498	VNN2_HUMAN	vanin 2	123	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GCTGAGTCTTGCTTGTACTGG	0.368000													4	8					0.184627	0.186163	0.184627	1	0
OGFR	11054	broad.mit.edu	37	20	61439626	61439626	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:61439626G>T	ENST00000370461.1	+	1	2389	c.112G>T	c.(112-114)Gac>Tac	p.D38Y	OGFR_ENST00000290291.6_Missense_Mutation_p.D90Y|OGFR_ENST00000370468.3_Missense_Mutation_p.D90Y			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	90				DAGDEDEESEEPRAARPSSFQSRMTGSRNWRATRDMCRYRH NYP -> GARRALGVLGQPGGLQMRLPERHGGPQGSLCLMD PCCPLSLALQ (in Ref. 5).	regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					CTGCAATGGGGACACGCCAAA	0.587000											OREG0026118	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	41					1.39649e-27	2.24475e-27	0.760397	1	0
TTN	7273	broad.mit.edu	37	2	179635205	179635205	+	Missense_Mutation	SNP	C	C	T	rs143035953	byFrequency	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:179635205C>T	ENST00000589042.1	-	35	8538	c.8314G>A	c.(8314-8316)Gtg>Atg	p.V2772M	TTN_ENST00000359218.5_Missense_Mutation_p.V2726M|TTN_ENST00000342992.6_Missense_Mutation_p.V2772M|TTN_ENST00000360870.5_Missense_Mutation_p.V2772M|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V2726M|TTN_ENST00000591111.1_Missense_Mutation_p.V2772M|TTN_ENST00000460472.2_Missense_Mutation_p.V2726M	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2510							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.V2726L(3)|p.V2772L(2)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTCATCCACGATGGCACAG	0.433000													33	66					0	0	0.750413	0	0
RASAL2	9462	broad.mit.edu	37	1	178269185	178269185	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:178269185G>T	ENST00000448150.3	+	3	1153	c.335G>T	c.(334-336)aGg>aTg	p.R112M	RASAL2_ENST00000367649.3_Missense_Mutation_p.R130M|RASAL2_ENST00000465723.1_3'UTR	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	0	PH.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CGATGCCTGAGGAGAACTGTC	0.468000											OREG0014010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	122					3.69857e-22	5.58935e-22	0.729181	1	0
SLC43A2	124935	broad.mit.edu	37	17	1494673	1494673	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:1494673C>A	ENST00000571650.1	-	8	1127	c.821G>T	c.(820-822)aGt>aTt	p.S274I	SLC43A2_ENST00000574274.1_5'UTR|SLC43A2_ENST00000382147.4_Missense_Mutation_p.S274I|SLC43A2_ENST00000412517.3_Missense_Mutation_p.S137I|SLC43A2_ENST00000301335.4_Missense_Mutation_p.S274I			Q8N370	LAT4_HUMAN	solute carrier family 43 (amino acid system L transporter), member 2	274					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				endometrium(4)|large_intestine(4)|liver(1)|lung(2)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		GCTGCCCACACTCAGGCGCCG	0.632000													69	16					6.09464e-36	1.04038e-35	0.870114	1	0
KCNA4	3739	broad.mit.edu	37	11	30032336	30032336	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:30032336C>T	ENST00000328224.6	-	2	3123	c.1890G>A	c.(1888-1890)caG>caA	p.Q630Q		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	630						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCCCTTTCCCTGACACTTCT	0.478000													48	81					0	0	0.870114	0	0
NRG3	10718	broad.mit.edu	37	10	84118494	84118494	+	Splice_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:84118494G>T	ENST00000372142.2	+	3	434		c.e3-1		NRG3_ENST00000556918.1_Splice_Site|NRG3_ENST00000372141.2_Splice_Site|NRG3_ENST00000404547.1_Splice_Site|NRG3_ENST00000404576.2_Splice_Site	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3						regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		TTCCCTGACAGATACGACGAC	0.517000													26	141					7.16026e-08	8.24927e-08	0.760397	1	0
SPSB1	80176	broad.mit.edu	37	1	9416296	9416296	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:9416296G>T	ENST00000328089.6	+	2	687	c.346G>T	c.(346-348)Ggg>Tgg	p.G116W	SPSB1_ENST00000377399.2_Missense_Mutation_p.G116W|SPSB1_ENST00000357898.3_Missense_Mutation_p.G116W	NM_025106.3	NP_079382.2	Q96BD6	SPSB1_HUMAN	splA/ryanodine receptor domain and SOCS box containing 1	116	B30.2/SPRY.				intracellular signal transduction	cytoplasm				breast(1)|endometrium(3)|kidney(2)|lung(5)|prostate(2)	13	all_lung(157;0.194)	all_epithelial(116;4.38e-15)|all_lung(118;0.000156)|Lung NSC(185;0.000446)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.72e-07)|COAD - Colon adenocarcinoma(227;9.12e-05)|Kidney(185;0.000296)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00193)|BRCA - Breast invasive adenocarcinoma(304;0.00202)|READ - Rectum adenocarcinoma(331;0.0419)		CGCCGTGGTGGGGGTGGCGAC	0.667000													35	82					1.45844e-13	1.89253e-13	0.769981	1	0
RYR3	6263	broad.mit.edu	37	15	33955859	33955859	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:33955859A>T	ENST00000389232.4	+	36	5610	c.5540A>T	c.(5539-5541)gAg>gTg	p.E1847V	RYR3_ENST00000415757.3_Missense_Mutation_p.E1847V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1847	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CGCTACAATGAGCTCATGCAG	0.577000													6	13					0	0	0.278610	0	0
PEAK1	79834	broad.mit.edu	37	15	77425347	77425347	+	Splice_Site	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:77425347C>G	ENST00000560626.2	-	6	4552	c.4077_splice	c.e6+1	p.K1359_splice	PEAK1_ENST00000312493.4_Splice_Site_p.K1359_splice			Q9H792	PEAK1_HUMAN	pseudopodium-enriched atypical kinase 1	1359	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding										ATTTTCTTACCTTGACTGCAT	0.368000													26	35					0	0	0.706142	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202920093	202920093	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:202920093C>A	ENST00000340990.5	-	2	404	c.106G>T	c.(106-108)Gag>Tag	p.E36*	ADIPOR1_ENST00000436244.1_Nonsense_Mutation_p.E36*|ADIPOR1_ENST00000367254.3_Nonsense_Mutation_p.E36*	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	36					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			TTGCCCTTCTCTTCTAGCAGG	0.527000													85	109					5.00475e-40	8.71517e-40	0.870114	1	0
GPR83	10888	broad.mit.edu	37	11	94113891	94113891	+	Silent	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:94113891A>G	ENST00000243673.2	-	4	867	c.696T>C	c.(694-696)gcT>gcC	p.A232A	GPR83_ENST00000539203.2_Silent_p.A190A	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	232						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AGAAGAGGTCAGCTGGCTCAG	0.572000													16	39					0	0	0.624587	0	0
EPB42	2038	broad.mit.edu	37	15	43501491	43501491	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:43501491C>A	ENST00000300215.3	-	6	1360	c.903G>T	c.(901-903)ttG>ttT	p.L301F	EPB42_ENST00000441366.2_Missense_Mutation_p.L271F|EPB42_ENST00000540029.1_Missense_Mutation_p.L193F			P16452	EPB42_HUMAN	erythrocyte membrane protein band 4.2	271					erythrocyte maturation|peptide cross-linking|regulation of cell shape	cytoplasm|cytoskeleton|plasma membrane	ATP binding|protein binding|protein-glutamine gamma-glutamyltransferase activity|structural constituent of cytoskeleton			endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.7e-07)		CAACAGCAGCCAACACCCAGG	0.632000													12	25					1.52009e-12	1.95995e-12	0.479597	1	0
KLF17	128209	broad.mit.edu	37	1	44595665	44595665	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:44595665G>T	ENST00000372299.3	+	2	780	c.722G>T	c.(721-723)aGt>aTt	p.S241I	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	241					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					TCTCTTGTCAGTCAGCCAGAC	0.557000													27	72					2.68265e-12	3.42972e-12	0.769981	1	0
USP33	23032	broad.mit.edu	37	1	78187836	78187836	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:78187836G>A	ENST00000370793.1	-	14	1874	c.1528C>T	c.(1528-1530)Cct>Tct	p.P510S	USP33_ENST00000370792.3_Missense_Mutation_p.P510S|USP33_ENST00000370794.3_Missense_Mutation_p.P479S|USP33_ENST00000357428.1_Missense_Mutation_p.P510S	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	510					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						TCCTTGCCAGGAATTGGCAAG	0.413000													30	69					0	0	0.788014	0	0
HGF	3082	broad.mit.edu	37	7	81358978	81358978	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:81358978C>A	ENST00000222390.5	-	8	1209	c.983G>T	c.(982-984)cGt>cTt	p.R328L	HGF_ENST00000457544.2_Missense_Mutation_p.R323L	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	328	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						AGAATCCCAACGCTGACATGG	0.443000													37	101					1.57019e-19	2.2764e-19	0.834066	1	0
POTEF	728378	broad.mit.edu	37	2	130877831	130877831	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:130877831G>A	ENST00000357462.5	-	1	351	c.258C>T	c.(256-258)caC>caT	p.H86H	POTEF_ENST00000361163.4_Silent_p.H86H|POTEF_ENST00000409914.2_Silent_p.H86H|POTEF_ENST00000360967.5_Silent_p.H86H			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	86						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CAGAGTCGTCGTGGTCTCCAG	0.602000													41	336					0	0	0.870114	0	0
LCT	3938	broad.mit.edu	37	2	136567238	136567238	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:136567238G>T	ENST00000264162.2	-	8	2689	c.2679C>A	c.(2677-2679)ttC>ttA	p.F893L		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	893	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AATCTCTTTCGAACTTGGGTT	0.522000													36	66					2.43468e-25	3.78312e-25	0.870114	1	0
BRCC3	79184	broad.mit.edu	37	X	154344388	154344388	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:154344388T>A	ENST00000369462.1	+	9	705	c.680T>A	c.(679-681)gTg>gAg	p.V227E	MTCP1_ENST00000362018.2_Intron|BRCC3_ENST00000399042.1_Missense_Mutation_p.V227E|BRCC3_ENST00000369459.2_Intron|BRCC3_ENST00000330045.7_Missense_Mutation_p.V202E|BRCC3_ENST00000340647.4_Missense_Mutation_p.V203E	NM_024332.3	NP_077308.1	P46736	BRCC3_HUMAN	BRCA1/BRCA2-containing complex, subunit 3	227					double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|positive regulation of DNA repair|response to X-ray	BRCA1-A complex|BRISC complex|nuclear ubiquitin ligase complex	enzyme regulator activity|metal ion binding|metallopeptidase activity|polyubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|pancreas(1)|skin(1)	22	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					ATCGGGAAAGTGTGCCTTGAA	0.483000													12	17					0	0	0.557998	0	0
APOB	338	broad.mit.edu	37	2	21229797	21229797	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:21229797G>T	ENST00000233242.1	-	26	10070	c.9943C>A	c.(9943-9945)Ctt>Att	p.L3315I		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3315					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GGAAGAGAAAGCTTGAGATTT	0.403000													21	75					1.87028e-06	2.08728e-06	0.608945	1	0
NXPE4	54827	broad.mit.edu	37	11	114450956	114450956	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:114450956C>T	ENST00000375478.3	-	5	1177	c.997G>A	c.(997-999)Gct>Act	p.A333T	NXPE4_ENST00000424261.2_Missense_Mutation_p.A49T	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4																		TTGACTGTAGCCAAACTACAG	0.438000													48	69					0	0	0.870114	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47122352	47122352	+	Splice_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:47122352G>T	ENST00000290341.3	+	12	1654		c.e12-1		IGF2BP1_ENST00000431824.2_Splice_Site	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1						CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						TTGCTTTTTAGATTGCACCAC	0.478000													84	127					8.61805e-73	1.5874e-72	0.870114	1	0
OR5D16	390144	broad.mit.edu	37	11	55606407	55606407	+	Silent	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:55606407C>G	ENST00000378396.1	+	1	180	c.180C>G	c.(178-180)ccC>ccG	p.P60P		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TGCATACCCCCATGTATTTTT	0.433000													53	191					0	0	0.870114	0	0
NOP14	8602	broad.mit.edu	37	4	2964864	2964864	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:2964864C>A	ENST00000416614.2	-	1	248	c.183G>T	c.(181-183)cgG>cgT	p.R61R	NOP14_ENST00000502735.1_Silent_p.R61R|NOP14_ENST00000398071.4_Silent_p.R61R|NOP14_ENST00000314262.6_Silent_p.R61R			P78316	NOP14_HUMAN	NOP14 nucleolar protein	61					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	mitochondrion|Noc4p-Nop14p complex|small-subunit processome	snoRNA binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(9)|lung(12)|pancreas(1)|skin(1)|urinary_tract(1)	30						TCCTGAGGGCCCGTGCGCGAG	0.667000													50	63					7.10676e-39	1.23049e-38	0.870114	1	0
LRFN5	145581	broad.mit.edu	37	14	42357153	42357153	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:42357153C>A	ENST00000554171.1	+	5	3757	c.1325C>A	c.(1324-1326)cCt>cAt	p.P442H	LRFN5_ENST00000298119.4_Missense_Mutation_p.P442H|LRFN5_ENST00000554120.1_Missense_Mutation_p.P442H			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	442	Fibronectin type-III.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AGAAATATCCCTGGAATACGT	0.333000										HNSCC(30;0.082)			10	24					1.61879e-10	1.97382e-10	0.411799	1	0
NRK	203447	broad.mit.edu	37	X	105181509	105181509	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:105181509T>C	ENST00000428173.2	+	22	4040	c.3737T>C	c.(3736-3738)aTa>aCa	p.I1246T	NRK_ENST00000243300.9_Missense_Mutation_p.I1245T			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1245	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						ACTAAACTTATAAGGCGAAGA	0.373000										HNSCC(51;0.14)			8	23					0	0	0.387290	0	0
ESR2	2100	broad.mit.edu	37	14	64727335	64727335	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:64727335C>T	ENST00000557772.1	-	4	783	c.784G>A	c.(784-786)Gcc>Acc	p.A262T	ESR2_ENST00000555483.1_5'UTR|ESR2_ENST00000357782.2_Missense_Mutation_p.A262T|ESR2_ENST00000358599.5_Missense_Mutation_p.A262T|ESR2_ENST00000341099.4_Missense_Mutation_p.A262T|ESR2_ENST00000555278.1_Missense_Mutation_p.A262T|ESR2_ENST00000267525.6_Missense_Mutation_p.A262T|ESR2_ENST00000353772.3_Missense_Mutation_p.A262T|ESR2_ENST00000554572.1_Missense_Mutation_p.A262T|ESR2_ENST00000553796.1_Missense_Mutation_p.A262T|ESR2_ENST00000542956.1_Missense_Mutation_p.A262T	NM_001214903.1	NP_001201832.1	Q92731	ESR2_HUMAN	estrogen receptor 2 (ER beta)	262	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	23				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GGGCTCAGGGCGTCCAGCAGC	0.682000													19	9					0	0	0.557998	0	0
ZNF394	84124	broad.mit.edu	37	7	99097565	99097565	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:99097565G>A	ENST00000337673.6	-	1	355	c.152C>T	c.(151-153)cCc>cTc	p.P51L	ZNF789_ENST00000494186.1_Intron|ZNF394_ENST00000426306.2_Missense_Mutation_p.P51L|ZNF394_ENST00000394177.3_Intron|ZNF789_ENST00000493485.1_Intron	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	51					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GGGATAGTTGGGCTCCCAACT	0.647000													47	26					0	0	0.870114	0	0
SLFN5	162394	broad.mit.edu	37	17	33585709	33585709	+	Translation_Start_Site	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:33585709G>A	ENST00000299977.4	+	0	148				SLFN5_ENST00000542451.1_De_novo_Start_InFrame|SLFN5_ENST00000592325.1_De_novo_Start_InFrame	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5						cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GTGCTGAGAAGATGAGTCTTA	0.448000													48	59					0	0	0.870114	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874385	74874385	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:74874385G>T	ENST00000331628.3	-	4	817	c.570C>A	c.(568-570)gcC>gcA	p.A190A	SYNDIG1L_ENST00000554823.1_Silent_p.A190A	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	190					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						CTTTGGAGATGGCCTTGCTGG	0.657000													31	55					4.62619e-21	6.87125e-21	0.796494	1	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253764	32253764	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr21:32253764G>T	ENST00000332378.4	-	1	110	c.80C>A	c.(79-81)aCc>aAc	p.T27N		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	27						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						GGAAGTCGTGGTAACTTGGGC	0.557000													23	54					2.48779e-11	3.0957e-11	0.693898	1	0
EP400	57634	broad.mit.edu	37	12	132512784	132512784	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:132512784A>T	ENST00000333577.4	+	28	5549	c.5440A>T	c.(5440-5442)Atg>Ttg	p.M1814L	EP400_ENST00000332482.4_Missense_Mutation_p.M1741L|EP400_ENST00000389561.2_Missense_Mutation_p.M1778L|EP400_ENST00000389562.2_Missense_Mutation_p.M1777L|EP400_ENST00000330386.6_Missense_Mutation_p.M1697L			Q96L91	EP400_HUMAN	E1A binding protein p400	1814					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		AAGTGAGCTGATGTTGACGCT	0.572000													26	220					0	0	0.729181	0	0
SLC22A16	85413	broad.mit.edu	37	6	110763897	110763897	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:110763897G>T	ENST00000368919.3	-	4	799	c.733C>A	c.(733-735)Cat>Aat	p.H245N	SLC22A16_ENST00000456137.2_3'UTR|SLC22A16_ENST00000439654.1_Missense_Mutation_p.H245N|SLC22A16_ENST00000330550.4_Missense_Mutation_p.H211N	NM_033125.3	NP_149116.2	Q86VW1	S22AG_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 16	245					acid secretion|cell differentiation|multicellular organismal development|single fertilization|sperm motility|spermatogenesis	integral to membrane	carnitine transporter activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34		all_cancers(87;0.00221)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0485)|Colorectal(196;0.101)		OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.0921)|all cancers(137;0.115)		GAATGCAAATGGACAGACGCC	0.473000													33	7					1.99505e-19	2.87858e-19	0.760397	1	0
ABCA13	154664	broad.mit.edu	37	7	48452032	48452032	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:48452032T>C	ENST00000435803.1	+	41	12335	c.12311T>C	c.(12310-12312)cTc>cCc	p.L4104P		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4104					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CAAGCATTTCTCAAAGACAGC	0.463000													13	34					0	0	0.411799	0	0
MROH6	642475	broad.mit.edu	37	8	144652231	144652231	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:144652231T>C	ENST00000398882.3	-	7	1304	c.1048A>G	c.(1048-1050)Atg>Gtg	p.M350V		NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		TGTGCCACCATAGCACTGGGG	0.637000													9	45					0	0	0.387290	0	0
KIAA1109	84162	broad.mit.edu	37	4	123270673	123270673	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:123270673G>T	ENST00000264501.4	+	79	13880	c.13507G>T	c.(13507-13509)Gct>Tct	p.A4503S	KIAA1109_ENST00000388738.3_Missense_Mutation_p.A4503S			Q2LD37	K1109_HUMAN	KIAA1109	4503					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TTCTACTGAAGCTCGTGTTGA	0.348000													5	10					0.184627	0.186163	0.184627	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107460219	107460219	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:107460219C>A	ENST00000409382.3	-	2	825	c.215G>T	c.(214-216)gGg>gTg	p.G72V	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.G72V|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.G72V	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	72					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GTCCAGGCCCCCAGGCGGGGA	0.706000													11	8					3.07112e-06	3.4086e-06	0.387290	1	0
SERPINB3	6317	broad.mit.edu	37	18	61324569	61324569	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:61324569T>C	ENST00000283752.5	-	6	690	c.547A>G	c.(547-549)Aaa>Gaa	p.K183E	SERPINB3_ENST00000332821.8_Missense_Mutation_p.K183E|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	183					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CACTGCCCTTTGAAATAGATT	0.303000													25	6					0	0	0.769981	0	0
OPN4	94233	broad.mit.edu	37	10	88415952	88415952	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:88415952C>A	ENST00000372071.2	+	2	412	c.185C>A	c.(184-186)aCg>aAg	p.T62K	OPN4_ENST00000241891.5_Missense_Mutation_p.T62K	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	62					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						CCCCTCCCCACGGTTGATGTT	0.567000													47	47					4.10826e-27	6.48335e-27	0.870114	1	0
RASA3	22821	broad.mit.edu	37	13	114793323	114793323	+	Splice_Site	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:114793323C>A	ENST00000334062.7	-	6	651	c.530_splice	c.e6+1	p.R177_splice	RASA3_ENST00000542651.1_3'UTR|RASA3_ENST00000389544.4_Splice_Site_p.R145_splice	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	177	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			GGCAACTTGCCTGAAGGGTCC	0.602000													29	110					3.76114e-14	4.96568e-14	0.796494	1	0
IVNS1ABP	10625	broad.mit.edu	37	1	185270182	185270182	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:185270182C>T	ENST00000367498.3	-	10	1664	c.1042G>A	c.(1042-1044)Gaa>Aaa	p.E348K	IVNS1ABP_ENST00000459929.1_5'UTR|IVNS1ABP_ENST00000392007.3_Missense_Mutation_p.E130K	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	348	Sufficient for AHR interaction and signaling.				interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						ATGGGCTTTTCGATTAGCTCA	0.438000													31	87					0	0	0.819951	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709842	128709842	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:128709842G>T	ENST00000392665.2	-	2	441	c.297C>A	c.(295-297)caC>caA	p.H99Q	KCNJ1_ENST00000324036.3_Missense_Mutation_p.H99Q|KCNJ1_ENST00000392666.1_Missense_Mutation_p.H99Q|KCNJ1_ENST00000440599.2_Missense_Mutation_p.H99Q|KCNJ1_ENST00000392664.2_Missense_Mutation_p.H118Q	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	118			W -> C (in BS2).		excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CACAGGGAGTGTGATTGGCAG	0.463000													11	26					0.00829132	0.00855969	0.361761	1	0
NLRP4	147945	broad.mit.edu	37	19	56370072	56370072	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:56370072T>G	ENST00000301295.6	+	3	1735	c.1313T>G	c.(1312-1314)cTt>cGt	p.L438R	NLRP4_ENST00000587891.1_Missense_Mutation_p.L363R|NLRP4_ENST00000346986.5_Missense_Mutation_p.L438R	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	438	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		ACCAAGATACTTCTGAAGTAC	0.527000													31	43					0	0	0.769981	0	0
RALGPS2	55103	broad.mit.edu	37	1	178780464	178780464	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:178780464T>A	ENST00000367635.3	+	6	650	c.312T>A	c.(310-312)gtT>gtA	p.V104V	RALGPS2_ENST00000367634.2_Silent_p.V104V|RALGPS2_ENST00000324778.4_Silent_p.V69V	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	104	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						GCTTTTGGGTTGTTAGAGAGA	0.244000													41	53					0	0	0.870114	0	0
KRT6A	3853	broad.mit.edu	37	12	52885425	52885425	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:52885425C>A	ENST00000330722.6	-	2	704	c.636G>T	c.(634-636)ccG>ccT	p.P212P		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	212	Linker 1.|Rod.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCTCGAACAACGGCTCCAGGT	0.592000													29	113					4.34311e-12	5.52925e-12	0.779181	1	0
TRIM16L	147166	broad.mit.edu	37	17	18630883	18630883	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:18630883G>A	ENST00000449552.2	+	4	1497	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	TRIM16L_ENST00000395672.2_Missense_Mutation_p.E5K|TRIM16L_ENST00000414850.2_Missense_Mutation_p.E5K|TRIM16L_ENST00000571708.1_Missense_Mutation_p.E5K|TRIM16L_ENST00000572555.1_Missense_Mutation_p.E5K|TRIM16L_ENST00000395671.4_Missense_Mutation_p.E5K|TRIM16L_ENST00000395902.3_Missense_Mutation_p.E59K			Q309B1	TR16L_HUMAN	tripartite motif containing 16-like	5						cytoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)	9						GCAGTTTGGGGAACTCCTTGC	0.572000													27	116					0	0	0.840704	0	0
LMX1A	4009	broad.mit.edu	37	1	165183011	165183011	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:165183011T>A	ENST00000342310.3	-	5	918	c.536A>T	c.(535-537)cAt>cTt	p.H179L	LMX1A_ENST00000294816.2_Missense_Mutation_p.H179L|LMX1A_ENST00000367893.4_Missense_Mutation_p.H179L	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	179						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CCCTGCCCCATGGGCTGACTT	0.498000													82	69					0	0	0.870114	0	0
OR13H1	347468	broad.mit.edu	37	X	130678561	130678561	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:130678561G>A	ENST00000338616.3	+	1	612	c.514G>A	c.(514-516)Gtc>Atc	p.V172I		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					TGGGGCTAATGTCATCAACCA	0.478000													97	126					0	0	0.870114	0	0
LRP1B	53353	broad.mit.edu	37	2	141359036	141359036	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:141359036G>T	ENST00000389484.3	-	42	7943	c.6972C>A	c.(6970-6972)gcC>gcA	p.A2324A		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2324					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTCATCCAAGGCTAGCACAT	0.388000										TSP Lung(27;0.18)			18	49					3.5997e-14	4.77334e-14	0.624587	1	0
POSTN	10631	broad.mit.edu	37	13	38171387	38171387	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:38171387C>G	ENST00000379747.4	-	2	269	c.152G>C	c.(151-153)gGc>gCc	p.G51A	POSTN_ENST00000541179.1_Missense_Mutation_p.G51A|POSTN_ENST00000379743.4_Missense_Mutation_p.G51A|POSTN_ENST00000379742.4_Missense_Mutation_p.G51A|POSTN_ENST00000379749.4_Missense_Mutation_p.G51A|POSTN_ENST00000541481.1_Missense_Mutation_p.G51A	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	51	EMI.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CTTTTTGGTGCCCAAAATCTG	0.348000													12	16					0	0	0.457914	0	0
NDST4	64579	broad.mit.edu	37	4	115997732	115997732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:115997732C>A	ENST00000264363.2	-	2	1139	c.461G>T	c.(460-462)tGt>tTt	p.C154F		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	154	Heparan sulfate N-deacetylase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTATTCCACACAGTATTTTTC	0.323000													15	37					8.04996e-18	1.13448e-17	0.608945	1	0
WAS	7454	broad.mit.edu	37	X	48546836	48546836	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:48546836C>T	ENST00000376701.4	+	9	1000	c.925C>T	c.(925-927)Cgc>Tgc	p.R309C		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	309					blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				GGAGATGAGGCGCCAGGGTGA	0.562000			"""Mis, N, F, S"""			lymphoma							12	27					0	0	0.520397	0	0
PCDHB16	57717	broad.mit.edu	37	5	140562949	140562949	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:140562949G>C	ENST00000361016.2	+	1	1970	c.815G>C	c.(814-816)gGa>gCa	p.G272A		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		272	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.G272L(1)|p.G272V(1)		breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTAGACGGCGGAGCCAATGGA	0.488000													47	10					0	0	0.870114	0	0
SLC8A3	6547	broad.mit.edu	37	14	70515616	70515616	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:70515616C>T	ENST00000381269.2	-	7	3028	c.2275G>A	c.(2275-2277)Gcc>Acc	p.A759T	SLC8A3_ENST00000534137.1_Missense_Mutation_p.A756T|SLC8A3_ENST00000357887.3_Missense_Mutation_p.A757T|SLC8A3_ENST00000216568.7_Missense_Mutation_p.A130T|SLC8A3_ENST00000356921.2_Missense_Mutation_p.A753T|SLC8A3_ENST00000394330.2_Missense_Mutation_p.A116T|SLC8A3_ENST00000528359.1_Missense_Mutation_p.A757T|SLC8A3_ENST00000533541.1_Missense_Mutation_p.A116T	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	759					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		ATGGAGACGGCGAAGCAGGCC	0.572000													20	19					0	0	0.639603	0	0
ZNF208	7757	broad.mit.edu	37	19	22170020	22170020	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:22170020G>C	ENST00000397126.4	-	3	372	c.224C>G	c.(223-225)cCa>cGa	p.P75R	ZNF208_ENST00000599916.1_Missense_Mutation_p.P75R|ZNF208_ENST00000597040.1_Missense_Mutation_p.P43R|ZNF208_ENST00000601773.1_Missense_Mutation_p.P75R	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCACCTACCTGGGGATTCTTC	0.443000													10	27					0	0	0.335167	0	0
TMEM106C	79022	broad.mit.edu	37	12	48361989	48361989	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:48361989G>T	ENST00000429772.2	+	8	843	c.730G>T	c.(730-732)Gga>Tga	p.G244*	TMEM106C_ENST00000256686.6_Nonsense_Mutation_p.G225*|TMEM106C_ENST00000550552.1_Nonsense_Mutation_p.G225*|TMEM106C_ENST00000449758.2_Nonsense_Mutation_p.G225*|TMEM106C_ENST00000552561.1_Nonsense_Mutation_p.G244*|TMEM106C_ENST00000552546.1_Nonsense_Mutation_p.G173*	NM_001143842.1	NP_001137314.1	Q9BVX2	T106C_HUMAN	transmembrane protein 106C	244						endoplasmic reticulum membrane|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	14		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TGTGGATTGTGGAGGAAATTC	0.448000													53	48					3.07184e-27	4.88592e-27	0.870114	1	0
GBP1P1	400759	broad.mit.edu	37	1	89886666	89886666	+	RNA	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:89886666C>G	ENST00000513638.1	+	0	444					NR_003133.2																						ACTCCTGGATCTTCGCCCTGG	0.498000													12	66					0	0	0.457914	0	0
IFNA10	3446	broad.mit.edu	37	9	21206925	21206925	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:21206925C>A	ENST00000357374.2	-	1	217	c.172G>T	c.(172-174)Gat>Tat	p.D58Y		NM_002171.1	NP_002162.1	P01566	IFN10_HUMAN	interferon, alpha 10	58					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|large_intestine(3)|liver(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	16				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		ATTCGGAAATCATGTCTGTCC	0.512000													65	32					2.08929e-35	3.54652e-35	0.870114	1	0
CCDC135	84229	broad.mit.edu	37	16	57734084	57734084	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:57734084A>T	ENST00000360716.3	+	5	627	c.406A>T	c.(406-408)Aca>Tca	p.T136S	RP11-405F3.4_ENST00000563062.1_RNA|CCDC135_ENST00000336825.8_Missense_Mutation_p.T136S|CCDC135_ENST00000394337.4_Missense_Mutation_p.T136S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	136						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CCTCCGGCCCACACTGATGCC	0.577000													76	221					0	0	0.870114	0	0
F13A1	2162	broad.mit.edu	37	6	6167839	6167839	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:6167839G>T	ENST00000264870.3	-	13	2025	c.1760C>A	c.(1759-1761)gCg>gAg	p.A587E		NM_000129.3	NP_000120.2	P00488	F13A_HUMAN	coagulation factor XIII, A1 polypeptide	587					peptide cross-linking|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	62	Ovarian(93;0.0816)	all_hematologic(90;0.152)			L-Glutamine(DB00130)	GATCAGCACCGCCTCTTTCTT	0.527000													5	24					2.0095e-06	2.23852e-06	0.248553	1	0
SLC17A4	10050	broad.mit.edu	37	6	25770367	25770367	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:25770367G>T	ENST00000377905.4	+	4	489	c.370G>T	c.(370-372)Gct>Tct	p.A124S	SLC17A4_ENST00000439485.2_Intron|SLC17A4_ENST00000397076.2_Intron	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	124					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CTCATTCTTGGCTCCAATCCC	0.478000													41	116					7.05121e-23	1.07363e-22	0.853193	1	0
RP1	6101	broad.mit.edu	37	8	55540628	55540628	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:55540628T>A	ENST00000220676.1	+	4	4334	c.4186T>A	c.(4186-4188)Tta>Ata	p.L1396I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1396					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGTCAGTAATTTAAGCTCCTG	0.323000													4	109					0	0	0.248553	0	0
C5orf54	63920	broad.mit.edu	37	5	159821765	159821765	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:159821765C>T	ENST00000408953.3	-	2	1240	c.733G>A	c.(733-735)Gcc>Acc	p.A245T	C5orf54_ENST00000523213.1_Missense_Mutation_p.A245T	NM_022090.3	NP_071373.2	Q8IZ13	CE054_HUMAN	chromosome 5 open reading frame 54	245										breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	12						atagaggaggcaccatcagta	0.393000													28	41					0	0	0.750413	0	0
RIMBP3	85376	broad.mit.edu	37	22	20458191	20458191	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr22:20458191G>T	ENST00000426804.1	-	1	3595	c.3111C>A	c.(3109-3111)ggC>ggA	p.G1037G		NM_015672.1	NP_056487.1			RIMS binding protein 3											breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	13	Colorectal(54;0.0993)|Melanoma(16;0.165)		LUSC - Lung squamous cell carcinoma(15;0.0405)|Lung(15;0.224)			AGCAGCTCACGCCCGCTGGGG	0.642000													5	24					0.0293803	0.0300751	0.248553	1	0
AARS2	57505	broad.mit.edu	37	6	44270197	44270197	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:44270197C>A	ENST00000244571.4	-	18	2420	c.2418G>T	c.(2416-2418)cgG>cgT	p.R806R	TMEM151B_ENST00000438774.2_Intron	NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	806					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CCAGACTCAGCCGCTCAGTGG	0.637000													28	25					6.07407e-21	8.97778e-21	0.717897	1	0
ZNF470	388566	broad.mit.edu	37	19	57086030	57086030	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:57086030G>T	ENST00000330619.8	+	5	897	c.211G>T	c.(211-213)Gtg>Ttg	p.V71L	ZNF470_ENST00000391709.3_Missense_Mutation_p.V71L|ZNF470_ENST00000601902.1_Missense_Mutation_p.V71L	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TAAACCAGATGTGATCTCCTT	0.413000													12	25					5.50884e-06	6.08079e-06	0.411799	1	0
NAV3	89795	broad.mit.edu	37	12	78598773	78598773	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:78598773C>G	ENST00000397909.2	+	39	7066	c.6893C>G	c.(6892-6894)cCa>cGa	p.P2298R	NAV3_ENST00000266692.7_Missense_Mutation_p.P2099R|NAV3_ENST00000228327.6_Missense_Mutation_p.P2276R|NAV3_ENST00000541270.1_Missense_Mutation_p.P128R|NAV3_ENST00000536525.2_Missense_Mutation_p.P2276R			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2298						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GACACATATCCATGGAGCTCA	0.468000										HNSCC(70;0.22)			37	24					0	0	0.870114	0	0
PCLO	27445	broad.mit.edu	37	7	82545274	82545274	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:82545274C>A	ENST00000423517.2	-	7	12365	c.12028G>T	c.(12028-12030)Gac>Tac	p.D4010Y	PCLO_ENST00000333891.8_Missense_Mutation_p.D4010Y|PCLO_ENST00000437081.1_Missense_Mutation_p.D730Y	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3941					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATTCTCAAGTCTAAACTATTG	0.393000													74	177					2.08937e-45	3.724e-45	0.870114	1	0
OR5P3	120066	broad.mit.edu	37	11	7847496	7847496	+	Silent	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:7847496A>G	ENST00000328375.1	-	1	23	c.24T>C	c.(22-24)acT>acC	p.T8T	RP11-35J10.5_ENST00000527565.1_lincRNA	NM_153445.1	NP_703146.1	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P, member 3	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)	15				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACTCTACCACAGTGGTGTCAT	0.348000													7	22					0	0	0.557998	0	0
IL2	3558	broad.mit.edu	37	4	123377472	123377472	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:123377472G>T	ENST00000226730.4	-	1	408	c.124C>A	c.(124-126)Cag>Aag	p.Q42K		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	42					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		AAAATCATCTGTAAATCCAGC	0.323000			T	TNFRSF17	intestinal T-cell lymphoma								11	19					0.000151284	0.000160558	0.435327	1	0
SOX6	55553	broad.mit.edu	37	11	15994631	15994631	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:15994631T>A	ENST00000352083.6	-	16	2288	c.2211A>T	c.(2209-2211)acA>acT	p.T737T	SOX6_ENST00000396356.3_Silent_p.T717T|SOX6_ENST00000528252.1_Silent_p.T710T|SOX6_ENST00000528429.1_Silent_p.T737T|SOX6_ENST00000527619.1_Silent_p.T713T|SOX6_ENST00000316399.6_Silent_p.T717T			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	737					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						CACCTGTTCCTGTGGTGATTG	0.458000													13	46					0	0	0.500413	0	0
LAMB1	3912	broad.mit.edu	37	7	107603453	107603453	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:107603453C>A	ENST00000393561.1	-	13	2010	c.1826G>T	c.(1825-1827)gGa>gTa	p.G609V	LAMB1_ENST00000393560.1_Missense_Mutation_p.G585V|LAMB1_ENST00000222399.6_Missense_Mutation_p.G585V			P07942	LAMB1_HUMAN	laminin, beta 1	585	Laminin IV type B.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GAAGCCGGCTCCAGTCCAGGA	0.483000													91	80					2.73351e-49	4.91545e-49	0.870114	1	0
AHNAK2	113146	broad.mit.edu	37	14	105412059	105412059	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:105412059G>T	ENST00000333244.5	-	7	9848	c.9729C>A	c.(9727-9729)ggC>ggA	p.G3243G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3243						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTATCTGGGGGCCCTTGCGAT	0.612000													45	63					1.17673e-23	1.80531e-23	0.870114	1	0
LINC00886	730091	broad.mit.edu	37	3	156528506	156528506	+	RNA	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:156528506C>A	ENST00000472943.1	-	0	148					NR_038387.1																						TCCTGCTGCTCATCCTTGCCC	0.567000													43	60					5.2432e-18	7.44117e-18	0.870114	1	0
OR4A16	81327	broad.mit.edu	37	11	55111575	55111575	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:55111575G>T	ENST00000314721.2	+	1	949	c.899G>T	c.(898-900)tGg>tTg	p.W300L		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						AAAAATCTCTGGTGTGAAAAG	0.318000													16	19					9.16793e-09	1.06842e-08	0.520397	1	0
LAMB2	3913	broad.mit.edu	37	3	49168209	49168209	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:49168209G>A	ENST00000418109.1	-	9	1164	c.1000C>T	c.(1000-1002)Cgt>Tgt	p.R334C	LAMB2_ENST00000305544.4_Missense_Mutation_p.R334C	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	334	Laminin EGF-like 1.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCAGCCGGACGCCAGGGCAGG	0.577000													4	158					0	0	0.150653	0	0
KRT37	8688	broad.mit.edu	37	17	39580623	39580623	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:39580623G>A	ENST00000225550.3	-	1	152	c.153C>T	c.(151-153)caC>caT	p.H51H	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	51	Head.					intermediate filament	structural molecule activity	p.H51H(1)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				CTCTGTTGGCGTGTGCCACGT	0.612000													4	131					0	0	0.184627	0	0
FLNC	2318	broad.mit.edu	37	7	128483612	128483612	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:128483612A>C	ENST00000325888.8	+	18	3053	c.2792A>C	c.(2791-2793)aAg>aCg	p.K931T	FLNC_ENST00000346177.6_Missense_Mutation_p.K931T	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	931					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						TACACTGTCAAGTACACCGCT	0.627000													3	111					0	0	0.150653	0	0
NEU2	4759	broad.mit.edu	37	2	233899621	233899621	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:233899621G>T	ENST00000233840.3	+	2	997	c.997G>T	c.(997-999)Gcc>Tcc	p.A333S		NM_005383.2	NP_005374.2	Q9Y3R4	NEUR2_HUMAN	sialidase 2 (cytosolic sialidase)	333							exo-alpha-sialidase activity			endometrium(3)|large_intestine(2)|lung(10)|skin(2)|urinary_tract(1)	18		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0271)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0839)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000311)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)|GBM - Glioblastoma multiforme(43;0.0488)		GGGCAGCTGTGCCTACTCAGA	0.612000													47	108					1.08114e-33	1.82499e-33	0.870114	1	0
FAM184A	79632	broad.mit.edu	37	6	119341148	119341148	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:119341148C>T	ENST00000338891.7	-	4	1770	c.1327G>A	c.(1327-1329)Gag>Aag	p.E443K	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000522284.1_Missense_Mutation_p.E323K|FAM184A_ENST00000352896.5_Missense_Mutation_p.E323K|FAM184A_ENST00000368475.4_Missense_Mutation_p.E323K|FAM184A_ENST00000521531.1_Missense_Mutation_p.E443K	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	443										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TTTACCTTCTCCAGTTCTAGA	0.403000													21	37					0	0	0.729181	0	0
BCAT1	586	broad.mit.edu	37	12	24989465	24989465	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:24989465G>A	ENST00000261192.7	-	8	1409	c.883C>T	c.(883-885)Ctg>Ttg	p.L295L	BCAT1_ENST00000538118.1_Silent_p.L294L|BCAT1_ENST00000539282.1_Silent_p.L307L|BCAT1_ENST00000544418.1_5'UTR|RP11-625L16.3_ENST00000545410.1_RNA|BCAT1_ENST00000342945.5_Silent_p.L234L|BCAT1_ENST00000539780.1_Silent_p.L258L	NM_001178091.1|NM_005504.6	NP_001171562.1|NP_005495.2	P54687	BCAT1_HUMAN	branched chain amino-acid transaminase 1, cytosolic	295					branched chain family amino acid biosynthetic process|branched chain family amino acid catabolic process|cell proliferation|G1/S transition of mitotic cell cycle	cytosol	L-isoleucine transaminase activity|L-leucine transaminase activity|L-valine transaminase activity			breast(1)|large_intestine(1)|lung(3)|prostate(2)	7	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Ovarian(17;0.107)|Colorectal(261;0.196)				Gabapentin(DB00996)|L-Glutamic Acid(DB00142)|L-Isoleucine(DB00167)|L-Leucine(DB00149)|L-Valine(DB00161)|Pyridoxal Phosphate(DB00114)	GCCAGGTCCAGAATGCACCGC	0.418000													82	37					0	0	0.870114	0	0
ZNF519	162655	broad.mit.edu	37	18	14106261	14106261	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:14106261C>G	ENST00000590202.1	-	3	430	c.278G>C	c.(277-279)gGa>gCa	p.G93A	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	93					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						TTCCTTTTGTCCTTCACCTTC	0.338000													12	75					0	0	0.411799	0	0
NRK	203447	broad.mit.edu	37	X	105181572	105181572	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:105181572C>G	ENST00000428173.2	+	22	4103	c.3800C>G	c.(3799-3801)tCa>tGa	p.S1267*	NRK_ENST00000243300.9_Nonsense_Mutation_p.S1266*			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1266	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						ATTACCATCTCAGGTTTGTTT	0.378000										HNSCC(51;0.14)			17	28					0	0	0.681144	0	0
RNF7	9616	broad.mit.edu	37	3	141457314	141457314	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:141457314A>G	ENST00000273480.3	+	1	269	c.131A>G	c.(130-132)gAc>gGc	p.D44G	RNF7_ENST00000393000.3_Missense_Mutation_p.D44G|RNF7_ENST00000480908.1_Missense_Mutation_p.D44G	NM_014245.4|NM_183237.2	NP_055060.1|NP_899060.1	Q9UBF6	RBX2_HUMAN	ring finger protein 7	44					anti-apoptosis|induction of apoptosis by oxidative stress|protein neddylation|response to redox state	cytoplasm|nucleus	copper ion binding|NEDD8 ligase activity|protein binding|zinc ion binding			kidney(1)|lung(3)|upper_aerodigestive_tract(1)	5						TGGAGCTGGGACGTGGAGTGC	0.672000											OREG0015854	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	11					0	0	0.500413	0	0
OR10V1	390201	broad.mit.edu	37	11	59480759	59480759	+	Missense_Mutation	SNP	C	C	G	rs141649641	byFrequency	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:59480759C>G	ENST00000307552.2	-	1	578	c.560G>C	c.(559-561)cGc>cCc	p.R187P		NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						ACAAGCCAGGCGCATGACTGC	0.483000													19	79					0	0	0.624587	0	0
COL1A2	1278	broad.mit.edu	37	7	94057008	94057008	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:94057008G>A	ENST00000297268.6	+	49	3808	c.3337G>A	c.(3337-3339)Gat>Aat	p.D1113N		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	1113					axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	CTTTGGTTACGATGGAGACTT	0.547000										HNSCC(75;0.22)			38	71					0	0	0.870114	0	0
CSTF1	1477	broad.mit.edu	37	20	54972439	54972439	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:54972439T>C	ENST00000217109.4	+	3	698	c.346T>C	c.(346-348)Tat>Cat	p.Y116H	CSTF1_ENST00000493039.1_3'UTR	NM_001033521.1|NM_001324.2	NP_001028693.1|NP_001315.1	Q05048	CSTF1_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa	116					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	15			Colorectal(105;0.202)			TGTAGCTACCTATAGTAGAGA	0.448000													71	227					0	0	0.870114	0	0
ANK2	287	broad.mit.edu	37	4	114278223	114278223	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:114278223A>T	ENST00000357077.4	+	38	8502	c.8449A>T	c.(8449-8451)Act>Tct	p.T2817S	ANK2_ENST00000264366.6_Missense_Mutation_p.T2784S|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2784					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TCTCCAAGGCACTCATGAAAA	0.453000													25	38					0	0	0.654019	0	0
GSAP	54103	broad.mit.edu	37	7	76978695	76978695	+	Silent	SNP	T	T	C	rs149462958		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:76978695T>C	ENST00000257626.7	-	19	1596	c.1518A>G	c.(1516-1518)acA>acG	p.T506T		NM_017439.3	NP_059135.2			gamma-secretase activating protein																		CAATGTCTTCTGTCACAAGAG	0.433000													30	77					0	0	0.812448	0	0
CTNNA2	1496	broad.mit.edu	37	2	80136846	80136846	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:80136846C>A	ENST00000466387.1	+	11	1703	c.979C>A	c.(979-981)Cgg>Agg	p.R327R	CTNNA2_ENST00000402739.4_Silent_p.R327R|CTNNA2_ENST00000496558.1_Silent_p.R327R|CTNNA2_ENST00000541047.1_Silent_p.R327R|CTNNA2_ENST00000361291.4_Silent_p.R361R|CTNNA2_ENST00000540488.1_Silent_p.R327R			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	327					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GCGAGACGACCGGCGCGAGAG	0.637000													44	23					2.78941e-39	4.8435e-39	0.870114	1	0
PLCB3	5331	broad.mit.edu	37	11	64032796	64032796	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:64032796C>T	ENST00000540288.1	+	25	2960	c.2857C>T	c.(2857-2859)Ccg>Tcg	p.P953S	PLCB3_ENST00000279230.6_Missense_Mutation_p.P953S|PLCB3_ENST00000325234.5_Missense_Mutation_p.P886S	NM_000932.2	NP_000923.1	Q01970	PLCB3_HUMAN	phospholipase C, beta 3 (phosphatidylinositol-specific)	953					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|urinary_tract(1)	33						GGCCCCCACCCCGCTGGATGA	0.687000													9	6					0	0	0.387290	0	0
RGS13	6003	broad.mit.edu	37	1	192627481	192627481	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:192627481C>A	ENST00000391995.2	+	6	566	c.278C>A	c.(277-279)cCa>cAa	p.P93Q	RGS13_ENST00000543215.1_Missense_Mutation_p.P93Q|RGS13_ENST00000482095.1_3'UTR	NM_002927.4	NP_002918.1	O14921	RGS13_HUMAN	regulator of G-protein signaling 13	93	RGS.					plasma membrane	GTPase activator activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|skin(1)	19						TACATCCAGCCACAGTCCCCT	0.423000													31	30					2.32173e-10	2.81958e-10	0.804634	1	0
PANK4	55229	broad.mit.edu	37	1	2452749	2452749	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:2452749T>A	ENST00000378466.3	-	3	225	c.213A>T	c.(211-213)acA>acT	p.T71T	PANK4_ENST00000491212.1_5'UTR|PANK4_ENST00000435556.3_Silent_p.T71T	NM_018216.1	NP_060686.1	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	71					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			breast(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	23	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GTTCACGTTCTGTGTCCTGGA	0.567000													55	41					0	0	0.870114	0	0
ABCA5	23461	broad.mit.edu	37	17	67300872	67300872	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:67300872A>C	ENST00000392676.3	-	7	932	c.868T>G	c.(868-870)Tta>Gta	p.L290V	ABCA5_ENST00000392677.2_Missense_Mutation_p.L290V|ABCA5_ENST00000588877.1_Missense_Mutation_p.L290V			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	290					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					TGAGGAAATAACAAAGAAGCT	0.323000													5	29					0	0	0.248553	0	0
OR2L13	284521	broad.mit.edu	37	1	248262757	248262757	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:248262757T>A	ENST00000366478.2	+	3	417	c.80T>A	c.(79-81)tTg>tAg	p.L27*	OR2L13_ENST00000358120.2_Nonsense_Mutation_p.L27*	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	27					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATATTTCTCTTGTGCCTTATC	0.438000													97	140					0	0	0.870114	0	0
GJD2	57369	broad.mit.edu	37	15	35044898	35044898	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:35044898C>T	ENST00000290374.4	-	2	1223	c.747G>A	c.(745-747)gaG>gaA	p.E249E		NM_020660.2	NP_065711.1	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	249					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity	p.E249D(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	19		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		AGACAGTCTTCTCAGTTGGCC	0.493000													24	34					0	0	0.706142	0	0
LCA5	167691	broad.mit.edu	37	6	80196775	80196775	+	Silent	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:80196775T>G	ENST00000392959.1	-	9	2651	c.2040A>C	c.(2038-2040)gcA>gcC	p.A680A	LCA5_ENST00000369846.4_Silent_p.A680A	NM_181714.3	NP_859065.2	Q86VQ0	LCA5_HUMAN	Leber congenital amaurosis 5	680					protein transport	cilium axoneme|microtubule basal body	protein binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(15)|prostate(2)|skin(1)	32		all_cancers(76;3.32e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.0176)		BRCA - Breast invasive adenocarcinoma(397;0.0657)		CTGCTTTTACTGCTGGTTTAT	0.338000													9	37					0	0	0.435327	0	0
MAGEC3	139081	broad.mit.edu	37	X	140984544	140984544	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:140984544G>A	ENST00000544766.1	+	5	633	c.106G>A	c.(106-108)Gag>Aag	p.E36K	MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000409007.1_Missense_Mutation_p.E36K|MAGEC3_ENST00000298296.1_Intron|MAGEC3_ENST00000536088.1_Missense_Mutation_p.E36K	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	430										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					AGATGAGGAGGAGGAGGATGc	0.517000													20	27					0	0	0.592651	0	0
LMBRD2	92255	broad.mit.edu	37	5	36122997	36122997	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:36122997G>A	ENST00000296603.4	-	8	1351	c.889C>T	c.(889-891)Cat>Tat	p.H297Y		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	297						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TAGATACTATGCTTTTCATCA	0.269000													19	123					0	0	0.717897	0	0
PTPRT	11122	broad.mit.edu	37	20	40733238	40733238	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:40733238T>G	ENST00000373198.3	-	26	3812	c.3577A>C	c.(3577-3579)Aac>Cac	p.N1193H	PTPRT_ENST00000373184.1_Missense_Mutation_p.N1181H|PTPRT_ENST00000373190.1_Missense_Mutation_p.N1170H|PTPRT_ENST00000373193.3_Missense_Mutation_p.N1174H|PTPRT_ENST00000373201.1_Missense_Mutation_p.N1161H|PTPRT_ENST00000356100.2_Missense_Mutation_p.N1180H|PTPRT_ENST00000373187.1_Missense_Mutation_p.N1171H	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1171	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TGGCTGGAGTTTGTCTGGGGG	0.478000													45	99					0	0	0.870114	0	0
TMEM150B	284417	broad.mit.edu	37	19	55828229	55828229	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:55828229G>A	ENST00000326652.4	-	7	612	c.430C>T	c.(430-432)Ccc>Tcc	p.P144S	TMEM150B_ENST00000438693.1_Missense_Mutation_p.P144S			A6NC51	T150B_HUMAN	transmembrane protein 150B	144						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)	3						CCGGGCTGGGGCAGCCTCTTC	0.632000													3	2					0	0	0.115264	0	0
KRTAP8-1	337879	broad.mit.edu	37	21	32185365	32185365	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr21:32185365C>A	ENST00000329621.4	-	1	205	c.174G>T	c.(172-174)tcG>tcT	p.S58S		NM_175857.3	NP_787053.1	Q8IUC2	KRA81_HUMAN	keratin associated protein 8-1	58						intermediate filament				central_nervous_system(1)|large_intestine(1)|lung(4)	6						GAGCAAATGGCGAGTATCTCC	0.562000													89	73					5.30237e-35	8.97552e-35	0.870114	1	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766861	171766861	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:171766861C>A	ENST00000311601.5	-	13	1418	c.1248G>T	c.(1246-1248)tgG>tgT	p.W416C	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	416	SH3 3.				adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGCCGGGGCCCACCCTTCCT	0.557000													17	7					7.45023e-12	9.44526e-12	0.592651	1	0
CCDC91	55297	broad.mit.edu	37	12	28458598	28458598	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:28458598T>C	ENST00000545336.1	+	7	545	c.126T>C	c.(124-126)ctT>ctC	p.L42L	CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000381259.1_Silent_p.L42L|CCDC91_ENST00000539107.1_Silent_p.L42L|CCDC91_ENST00000306172.5_Silent_p.L12L|CCDC91_ENST00000381256.1_Silent_p.L42L			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	42					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					GAGTCCATCTTTCACCATCTT	0.408000													74	300					0	0	0.870114	0	0
TRAV13-1	28671	broad.mit.edu	37	14	22337038	22337038	+	RNA	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:22337038C>A	ENST00000390436.2	+	0	19																											TTGGGAAGAACAAGGATGACA	0.423000													12	13					1.5739e-10	1.93073e-10	0.500413	1	0
RILP	83547	broad.mit.edu	37	17	1552920	1552920	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:1552920C>A	ENST00000301336.6	-	1	451	c.179G>T	c.(178-180)cGg>cTg	p.R60L		NM_031430.2	NP_113618.2	Q96NA2	RILP_HUMAN	Rab interacting lysosomal protein	60					endosome to lysosome transport|protein transport	late endosome membrane|lysosomal membrane|phagocytic vesicle membrane	Rab GTPase binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(4)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CTCCAGCGCCCGCACCACTAG	0.736000													4	4					0.000602214	0.00063358	0.184627	1	0
L3MBTL4	91133	broad.mit.edu	37	18	6301947	6301947	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:6301947C>A	ENST00000400104.3	-	4	282	c.82G>T	c.(82-84)Gaa>Taa	p.E28*	L3MBTL4_ENST00000317931.7_Nonsense_Mutation_p.E28*|L3MBTL4_ENST00000400105.2_Nonsense_Mutation_p.E28*|L3MBTL4_ENST00000284898.6_Nonsense_Mutation_p.E28*			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	28					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				TTTTCCTCTTCAGCTTGCTCC	0.373000													63	138					3.71121e-27	5.87204e-27	0.870114	1	0
CLEC7A	64581	broad.mit.edu	37	12	10271128	10271128	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:10271128C>A	ENST00000353231.5	-	5	693	c.535G>T	c.(535-537)Gtg>Ttg	p.V179L	CLEC7A_ENST00000396484.2_Missense_Mutation_p.V146L|CLEC7A_ENST00000533022.1_Missense_Mutation_p.R185L|CLEC7A_ENST00000298523.5_Missense_Mutation_p.R139L|CLEC7A_ENST00000304084.8_Missense_Mutation_p.V225L	NM_022570.4	NP_072092.2	Q9BXN2	CLC7A_HUMAN	C-type lectin domain family 7, member A	225	C-type lectin.				carbohydrate mediated signaling|defense response to protozoan|inflammatory response|innate immune response|phagocytosis, recognition|T cell activation	cytoplasm|integral to membrane	metal ion binding|MHC protein binding|sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						ATGACTGACACGTGAATCCAT	0.378000													66	75					4.49761e-31	7.46727e-31	0.870114	1	0
GABPB1	2553	broad.mit.edu	37	15	50595209	50595209	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:50595209C>T	ENST00000380877.3	-	4	811	c.388G>A	c.(388-390)Gta>Ata	p.V130I	GABPB1_ENST00000560825.1_Missense_Mutation_p.V130I|GABPB1_ENST00000359031.4_Missense_Mutation_p.V130I|GABPB1_ENST00000429662.2_Missense_Mutation_p.V130I|GABPB1_ENST00000543881.1_Missense_Mutation_p.V54I|GABPB1_ENST00000220429.8_Missense_Mutation_p.V130I|GABPB1_ENST00000396464.3_Missense_Mutation_p.V130I	NM_005254.5|NM_016654.4	NP_005245.2|NP_057738.1	Q06547	GABP1_HUMAN	GA binding protein transcription factor, beta subunit 1	130					positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			cervix(1)|endometrium(1)|large_intestine(7)|lung(5)	14						TGCGTGTGTACATCAGCACCA	0.353000													21	42					0	0	0.639603	0	0
SLC25A31	83447	broad.mit.edu	37	4	128651828	128651828	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:128651828G>T	ENST00000281154.4	+	1	296	c.128G>T	c.(127-129)cGg>cTg	p.R43L		NM_031291.2	NP_112581.1	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31	43					transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity			NS(1)|breast(1)|large_intestine(10)|lung(8)|skin(2)	22						CCCATCGAGCGGGTGAAGCTG	0.652000													13	30					7.93312e-07	8.88627e-07	0.457914	1	0
KIR2DL3	3804	broad.mit.edu	37	19	55263928	55263928	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:55263928C>T	ENST00000342376.3	+	8	1014	c.983C>T	c.(982-984)aCa>aTa	p.T328I	CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR2DL4_ENST00000396284.2_Intron	NM_015868.2	NP_056952.2			killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3											breast(1)|cervix(1)|large_intestine(1)|lung(11)|ovary(3)|pancreas(1)|skin(2)|urinary_tract(1)	21				GBM - Glioblastoma multiforme(193;0.0192)		ACACCCCCAACAGATATCATC	0.507000													89	160					0	0	0.870114	0	0
SLC12A9	56996	broad.mit.edu	37	7	100451777	100451777	+	Splice_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:100451777G>T	ENST00000354161.3	+	2	83		c.e2-1		SLC12A9_ENST00000275729.3_Splice_Site|SLC12A9_ENST00000540482.1_Splice_Site|SLC12A9_ENST00000415287.1_Splice_Site|SLC12A9_ENST00000428758.1_Splice_Site	NM_020246.3	NP_064631.2	Q9BXP2	S12A9_HUMAN	solute carrier family 12, member 9							integral to membrane|plasma membrane	cation:chloride symporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(20)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	41	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTCCTTTGCAGGTCACCTAAC	0.577000													10	33					0.00010058	0.000106932	0.411799	1	0
NNT	23530	broad.mit.edu	37	5	43616166	43616166	+	Splice_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:43616166G>T	ENST00000264663.5	+	4	819	c.599_splice	c.e4+1	p.G200_splice	NNT_ENST00000344920.4_Splice_Site_p.G200_splice|NNT_ENST00000512996.2_Splice_Site_p.G69_splice	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	200					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAACATTGCGGGGTAGGTTCT	0.413000													25	191					2.46105e-21	3.66437e-21	0.750413	1	0
EPHB6	2051	broad.mit.edu	37	7	142564038	142564038	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:142564038G>A	ENST00000392957.2	+	9	2213	c.1426G>A	c.(1426-1428)Gct>Act	p.A476T	EPHB6_ENST00000411471.2_Missense_Mutation_p.A199T|EPHB6_ENST00000442129.1_Missense_Mutation_p.A476T	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	476	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity	p.A461S(1)		NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					CCCTCCTCAGGCTGCAGCCAT	0.592000													13	31					0	0	0.520397	0	0
ELP4	26610	broad.mit.edu	37	11	31653874	31653874	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:31653874G>T	ENST00000395934.2	+	7	856	c.849G>T	c.(847-849)aaG>aaT	p.K283N	ELP4_ENST00000350638.5_Missense_Mutation_p.K283N|ELP4_ENST00000379163.5_Missense_Mutation_p.K284N			Q96EB1	ELP4_HUMAN	elongator acetyltransferase complex subunit 4	283					histone acetylation|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|Elongator holoenzyme complex|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)	20	Lung SC(675;0.225)					GCCTTACCAAGTTCCTCTATG	0.433000													48	63					2.17126e-26	3.39119e-26	0.870114	1	0
MYO7A	4647	broad.mit.edu	37	11	76912616	76912616	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:76912616G>T	ENST00000409709.3	+	36	5248	c.4976G>T	c.(4975-4977)cGt>cTt	p.R1659L	MYO7A_ENST00000458637.2_Missense_Mutation_p.R1621L|MYO7A_ENST00000409619.2_Missense_Mutation_p.R1610L	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1659	SH3.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						ACCAAGCAGCGTGGGGACTTC	0.612000													23	48					9.57634e-11	1.17952e-10	0.654019	1	0
TSNARE1	203062	broad.mit.edu	37	8	143399972	143399972	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:143399972T>C	ENST00000519651.1	-	5	363	c.260A>G	c.(259-261)aAc>aGc	p.N87S	TSNARE1_ENST00000518928.1_5'UTR|TSNARE1_ENST00000524325.1_Missense_Mutation_p.N306S|TSNARE1_ENST00000307180.3_Missense_Mutation_p.N306S|TSNARE1_ENST00000520166.1_Missense_Mutation_p.N306S			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	306					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					AATGGTCTTGTTGGTCTCCTG	0.667000													21	139					0	0	0.667858	0	0
CES1	1066	broad.mit.edu	37	16	55862853	55862853	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:55862853G>A	ENST00000422046.2	-	2	364	c.83C>T	c.(82-84)aCc>aTc	p.T28I	CES1_ENST00000360526.3_Missense_Mutation_p.T29I|CES1_ENST00000361503.4_Missense_Mutation_p.T28I			P23141	EST1_HUMAN	carboxylesterase 1	28				DT -> AK (in Ref. 14; AA sequence).|TV -> DT (in Ref. 15; AA sequence).	response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	GCCATGCACGGTGTCCACCAC	0.547000													4	13					0	0	0.184627	0	0
NEFM	4741	broad.mit.edu	37	8	24774808	24774808	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:24774808G>T	ENST00000221166.5	+	3	2222	c.1440G>T	c.(1438-1440)ttG>ttT	p.L480F	NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000433454.2_Missense_Mutation_p.L104F|NEFM_ENST00000437366.2_Missense_Mutation_p.L480F|NEFM_ENST00000518131.1_Missense_Mutation_p.L480F			P07197	NFM_HUMAN	neurofilament, medium polypeptide	480	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CAGAGGAATTGGCCGTTTCCA	0.458000													7	23					3.09899e-07	3.49068e-07	0.307466	1	0
HACE1	57531	broad.mit.edu	37	6	105231991	105231991	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:105231991C>T	ENST00000262903.4	-	14	1812	c.1536G>A	c.(1534-1536)atG>atA	p.M512I	HACE1_ENST00000369125.2_Missense_Mutation_p.M512I	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	512					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		TGAATCTTGACATCAACTCAG	0.269000													25	49					0	0	0.804634	0	0
OR11L1	391189	broad.mit.edu	37	1	248004784	248004784	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:248004784C>A	ENST00000355784.2	-	1	470	c.415G>T	c.(415-417)Ggg>Tgg	p.G139W		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCACAGAGCCCACGATGCATG	0.597000													43	42					5.44703e-19	7.84061e-19	0.847076	1	0
MEST	4232	broad.mit.edu	37	7	130140723	130140723	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:130140723C>T	ENST00000223215.4	+	9	962	c.741C>T	c.(739-741)gtC>gtT	p.V247V	MEST_ENST00000462132.1_3'UTR|MEST_ENST00000437945.1_Silent_p.V247V|MEST_ENST00000416162.2_Intron|MEST_ENST00000393187.1_Silent_p.V238V|MEST_ENST00000378576.4_Intron|MEST_ENST00000341441.4_Silent_p.V238V	NM_001253900.1|NM_002402.3	NP_001240829.1|NP_002393.2	Q5EB52	MEST_HUMAN	mesoderm specific transcript	247					mesoderm development	endoplasmic reticulum membrane|integral to membrane	hydrolase activity|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(2)	12	Melanoma(18;0.0435)					GGAACTTAGTCATTGACAGGT	0.502000													21	52					0	0	0.729181	0	0
OR11H1	81061	broad.mit.edu	37	22	16449697	16449697	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr22:16449697C>A	ENST00000252835.4	-	1	108	c.108G>T	c.(106-108)tgG>tgT	p.W36C		NM_001005239.1	NP_001005239.1	Q8NG94	O11H1_HUMAN	olfactory receptor, family 11, subfamily H, member 1	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)	11	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.208)		Kidney(3;0.00216)|KIRC - Kidney renal clear cell carcinoma(3;0.00244)|Lung(27;0.0724)|COAD - Colon adenocarcinoma(3;0.211)		TCTGAATTGTCCACTCACAAG	0.438000													20	139					1.4065e-29	2.32244e-29	0.788014	1	0
MTNR1A	4543	broad.mit.edu	37	4	187455599	187455599	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:187455599G>T	ENST00000307161.5	-	2	498	c.297C>A	c.(295-297)caC>caA	p.H99Q	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	99					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	TGACTTGGCAGTGCAGATAGC	0.552000													28	32					8.16721e-17	1.13257e-16	0.750413	1	0
MGAM	8972	broad.mit.edu	37	7	141740554	141740554	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:141740554C>A	ENST00000475668.2	+	21	2460	c.2406C>A	c.(2404-2406)gtC>gtA	p.V802V	MGAM_ENST00000549489.2_Silent_p.V802V			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	802	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGCAAAAAGTCGAGATGGAAC	0.468000													13	33					1.49906e-05	1.62801e-05	0.457914	1	0
TRPC4	7223	broad.mit.edu	37	13	38237637	38237637	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:38237637T>A	ENST00000379705.3	-	6	2461	c.1604A>T	c.(1603-1605)aAt>aTt	p.N535I	TRPC4_ENST00000338947.5_Missense_Mutation_p.N362I|TRPC4_ENST00000358477.2_Missense_Mutation_p.N535I|TRPC4_ENST00000447043.1_Missense_Mutation_p.N535I|TRPC4_ENST00000494529.1_5'UTR|TRPC4_ENST00000379679.1_Missense_Mutation_p.N362I|TRPC4_ENST00000379681.3_Missense_Mutation_p.N535I|TRPC4_ENST00000426868.2_Intron|TRPC4_ENST00000355779.2_Missense_Mutation_p.N535I|TRPC4_ENST00000379673.2_Missense_Mutation_p.N535I			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	535					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTACAATTGATTTAGGCCATT	0.373000													18	25					0	0	0.557998	0	0
SORL1	6653	broad.mit.edu	37	11	121428094	121428094	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:121428094G>T	ENST00000260197.7	+	19	2772	c.2643G>T	c.(2641-2643)ctG>ctT	p.L881L		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	881					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCAGGGCTCTGGTCCTCGTGC	0.507000													36	52					6.4771e-29	1.05798e-28	0.853193	1	0
PPP1R13L	10848	broad.mit.edu	37	19	45895537	45895537	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:45895537T>A	ENST00000418234.2	-	8	1494	c.1416A>T	c.(1414-1416)ccA>ccT	p.P472P	PPP1R13L_ENST00000360957.5_Silent_p.P472P	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	472	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CCTCCAGCACTGGTGTCAGCA	0.667000													16	31					0	0	0.557998	0	0
GBE1	2632	broad.mit.edu	37	3	81640187	81640187	+	Splice_Site	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:81640187C>A	ENST00000429644.2	-	9	1880		c.e9+1		GBE1_ENST00000489715.1_Splice_Site	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1						glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		TATGGCTTTACCTCAGCTATT	0.378000									Glycogen Storage Disease, type IV				7	28					1.12685e-05	1.2304e-05	0.307466	1	0
ADNP	23394	broad.mit.edu	37	20	49510039	49510039	+	Silent	SNP	C	C	A	rs139951165		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:49510039C>A	ENST00000396029.3	-	5	1779	c.1212G>T	c.(1210-1212)tcG>tcT	p.S404S	ADNP_ENST00000371602.4_Silent_p.S404S|ADNP_ENST00000396032.3_Silent_p.S404S|ADNP_ENST00000349014.3_Silent_p.S404S	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	404						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S404S(1)		NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						TTAACTGGCCCGATGAGAGAG	0.562000													18	107					2.37509e-13	3.07544e-13	0.592651	1	0
MCOLN2	255231	broad.mit.edu	37	1	85422123	85422123	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:85422123C>A	ENST00000370608.3	-	4	623	c.556G>T	c.(556-558)Gtt>Ttt	p.V186F	MCOLN2_ENST00000531325.1_5'UTR|MCOLN2_ENST00000284027.5_Missense_Mutation_p.V158F	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	186						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		CCGAGCTCAACGTCGTTGTCA	0.393000													34	96					4.32679e-17	6.02767e-17	0.827153	1	0
WBSCR17	64409	broad.mit.edu	37	7	70853241	70853241	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:70853241C>A	ENST00000333538.5	+	3	1077	c.443C>A	c.(442-444)tCc>tAc	p.S148Y	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	148						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				CTCAAGTACTCCAAGGACCTG	0.527000													21	58					2.41591e-17	3.38116e-17	0.681144	1	0
TMEM175	84286	broad.mit.edu	37	4	952220	952220	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:952220A>C	ENST00000264771.4	+	11	1636	c.1451A>C	c.(1450-1452)cAc>cCc	p.H484P	TMEM175_ENST00000508204.1_Missense_Mutation_p.H402P|TMEM175_ENST00000515740.1_Missense_Mutation_p.H368P	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	484						integral to membrane		p.H484P(1)		NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CGGCCCGAACACCCCCCGCCA	0.736000													9	17					0	0	0.500413	0	0
CHD4	1108	broad.mit.edu	37	12	6697584	6697584	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:6697584C>A	ENST00000309577.6	-	23	3508	c.3345G>T	c.(3343-3345)ccG>ccT	p.P1115P	CHD4_ENST00000357008.2_Silent_p.P1115P|CHD4_ENST00000544484.1_Silent_p.P1112P|CHD4_ENST00000544040.1_Silent_p.P1108P			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1115	Helicase C-terminal.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GCTGAGCACCCGGTGCTAATA	0.448000													18	91					9.57634e-11	1.17952e-10	0.654019	1	0
TBC1D28	254272	broad.mit.edu	37	17	18541988	18541988	+	Silent	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:18541988G>C	ENST00000345096.4	-	6	924	c.225C>G	c.(223-225)acC>acG	p.T75T	TBC1D28_ENST00000405044.1_Silent_p.T75T			Q2M2D7	TBC28_HUMAN	TBC1 domain family, member 28	75						intracellular	Rab GTPase activator activity			breast(1)|large_intestine(5)|lung(2)|ovary(1)	9						GCCACTTGTTGGTACGTTTAC	0.537000													44	59					0	0	0.870114	0	0
MIR487A	619555	broad.mit.edu	37	14	101518838	101518838	+	RNA	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:101518838C>A	ENST00000384827.1	+	0	56					NR_030162.1																						ACGAATCATACAGGGACATCC	0.527000													26	8					3.73988e-18	5.32012e-18	0.706142	1	0
BCHE	590	broad.mit.edu	37	3	165547891	165547891	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:165547891C>A	ENST00000264381.3	-	2	1097	c.931G>T	c.(931-933)Ggg>Tgg	p.G311W	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	311					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAAGGAGTCCCATAGGGGACA	0.393000													17	58					8.10497e-08	9.31995e-08	0.592651	1	0
KRT77	374454	broad.mit.edu	37	12	53096729	53096729	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:53096729C>T	ENST00000341809.3	-	1	518	c.490G>A	c.(490-492)Gag>Aag	p.E164K	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	164	Coil 1A.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TGCTCCCGCTCCTGGGTCTTG	0.532000													53	141					0	0	0.870114	0	0
MYLK3	91807	broad.mit.edu	37	16	46771658	46771658	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:46771658G>A	ENST00000394809.4	-	3	1081	c.966C>T	c.(964-966)gcC>gcT	p.A322A	MYLK3_ENST00000536476.1_Intron	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	322					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGGTTGCCCTGGCCTGGGCTG	0.677000													26	38					0	0	0.760397	0	0
CXADRP3	440224	broad.mit.edu	37	18	14478672	14478672	+	RNA	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:14478672G>T	ENST00000581457.1	-	0	1236					NR_024076.1																						TTTTTTTACAGATATAAACAG	0.418000													25	13					1.85244e-09	2.19683e-09	0.654019	1	0
CARD14	79092	broad.mit.edu	37	17	78162310	78162310	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:78162310G>T	ENST00000573882.1	+	7	1346	c.810G>T	c.(808-810)gaG>gaT	p.E270D	CARD14_ENST00000392434.2_Missense_Mutation_p.E33D|CARD14_ENST00000344227.2_Missense_Mutation_p.E270D|CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000570421.1_Missense_Mutation_p.E270D			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	270					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGAAGGAGGAGAATGAGAAAC	0.622000													29	62					5.04308e-16	6.88312e-16	0.819951	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299863	125299863	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:125299863C>A	ENST00000538699.1	-	2	125	c.45G>T	c.(43-45)gcG>gcT	p.A15A	DCAF12L2_ENST00000360028.2_Silent_p.A15A	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	15										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CCGCCTCGACCGCGGGCGCTT	0.746000													5	15					3.59834e-05	3.87316e-05	0.217242	1	0
EP400	57634	broad.mit.edu	37	12	132491379	132491379	+	Silent	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:132491379A>T	ENST00000333577.4	+	16	3478	c.3369A>T	c.(3367-3369)acA>acT	p.T1123T	EP400_ENST00000332482.4_Silent_p.T1050T|EP400_ENST00000389561.2_Silent_p.T1087T|EP400_ENST00000389562.2_Silent_p.T1086T|EP400_ENST00000330386.6_Silent_p.T1087T			Q96L91	EP400_HUMAN	E1A binding protein p400	1123	Helicase ATP-binding.|Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		TGGGTAAAACAGTGCAGATCA	0.428000													48	40					0	0	0.870114	0	0
BNIP2	663	broad.mit.edu	37	15	59971865	59971865	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:59971865A>G	ENST00000267859.3	-	4	677	c.584T>C	c.(583-585)tTg>tCg	p.L195S	BNIP2_ENST00000415213.2_Missense_Mutation_p.L136S|BNIP2_ENST00000607373.1_Missense_Mutation_p.L74S			Q12982	BNIP2_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 2	74	CRAL-TRIO.				anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			NS(1)|large_intestine(2)|lung(5)|ovary(1)	9						ACTTTCATCCAAATCATCTGA	0.393000													11	20					0	0	0.457914	0	0
PROL1	58503	broad.mit.edu	37	4	71275125	71275125	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:71275125G>C	ENST00000399575.2	+	3	254	c.80G>C	c.(79-81)aGa>aCa	p.R27T	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	27					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				TTCTCCAGAAGACCATATCTA	0.423000													20	28					0	0	0.624587	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788043	140788043	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:140788043C>A	ENST00000520790.1	+	1	274	c.274C>A	c.(274-276)Cgt>Agt	p.R92S	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGAATAGACCGTGAGCAAAT	0.483000													70	23					5.02048e-33	8.40445e-33	0.870114	1	0
ATG9B	285973	broad.mit.edu	37	7	150715481	150715481	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:150715481T>C	ENST00000605938.1	-	7	1847	c.1772A>G	c.(1771-1773)cAg>cGg	p.Q591R	ATG9B_ENST00000377974.2_Missense_Mutation_p.Q591R|ATG9B_ENST00000444312.1_Missense_Mutation_p.Q77R|ATG9B_ENST00000494791.1_5'UTR	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	591					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGGGCTGTCTGCAGCAGGAG	0.692000											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	28					0	0	0.539581	0	0
CENPJ	55835	broad.mit.edu	37	13	25466834	25466834	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:25466834T>A	ENST00000381884.4	-	10	3348	c.3163A>T	c.(3163-3165)Aga>Tga	p.R1055*	CENPJ_ENST00000545981.1_Nonsense_Mutation_p.R1055*	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1055					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		GCTTCTGCTCTCTTCCAGGCA	0.537000													49	68					0	0	0.870114	0	0
CENPF	1063	broad.mit.edu	37	1	214802428	214802428	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:214802428G>A	ENST00000366955.3	+	8	1276	c.1108G>A	c.(1108-1110)Gat>Aat	p.D370N		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	370	Interaction with SNAP25 and required for localization to the cytoplasm (By similarity).				cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		ATTGACGGAAGATTTGAGTTG	0.303000													18	50					0	0	0.639603	0	0
ADCY8	114	broad.mit.edu	37	8	131796020	131796020	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:131796020G>A	ENST00000286355.5	-	17	5277	c.3185C>T	c.(3184-3186)gCt>gTt	p.A1062V	ADCY8_ENST00000377928.3_Missense_Mutation_p.A931V	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	1062					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			GTCAGCCAGAGCACACAAATG	0.448000										HNSCC(32;0.087)			17	123					0	0	0.592651	0	0
TRIM71	131405	broad.mit.edu	37	3	32933250	32933250	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:32933250G>T	ENST00000383763.4	+	4	2617	c.2554G>T	c.(2554-2556)Gac>Tac	p.D852Y		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	852					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CATCACCCCCGACGGAATGAT	0.532000													70	106					2.26018e-36	3.8911e-36	0.870114	1	0
NEFM	4741	broad.mit.edu	37	8	24774809	24774809	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:24774809G>T	ENST00000221166.5	+	3	2223	c.1441G>T	c.(1441-1443)Gcc>Tcc	p.A481S	NEFM_ENST00000521540.1_3'UTR|NEFM_ENST00000433454.2_Missense_Mutation_p.A105S|NEFM_ENST00000437366.2_Missense_Mutation_p.A481S|NEFM_ENST00000518131.1_Missense_Mutation_p.A481S			P07197	NFM_HUMAN	neurofilament, medium polypeptide	481	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AGAGGAATTGGCCGTTTCCAT	0.458000													7	23					3.09899e-07	3.49068e-07	0.307466	1	0
IGHMBP2	3508	broad.mit.edu	37	11	68707074	68707074	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:68707074G>T	ENST00000255078.3	+	15	2968	c.2857G>T	c.(2857-2859)Ggc>Tgc	p.G953C		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	953					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CCTCTATGCCGGCAGCGGGAC	0.632000													12	29					9.05144e-12	1.14513e-11	0.435327	1	0
KIF1A	547	broad.mit.edu	37	2	241724474	241724474	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:241724474G>T	ENST00000498729.2	-	7	898	c.652C>A	c.(652-654)Cac>Aac	p.H218N	KIF1A_ENST00000320389.7_Missense_Mutation_p.H218N	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	218	Kinesin-motor.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		AAGACGGCGTGGGAGCGACTG	0.607000													64	199					2.36429e-26	3.68319e-26	0.870114	1	0
ASCL3	56676	broad.mit.edu	37	11	8959439	8959439	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:8959439G>T	ENST00000325884.1	-	2	329	c.270C>A	c.(268-270)taC>taA	p.Y90*	ASCL3_ENST00000531618.1_Nonsense_Mutation_p.Y90*	NM_020646.1	NP_065697.1	Q9NQ33	ASCL3_HUMAN	achaete-scute family bHLH transcription factor 3	89					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleolus	DNA binding	p.Y90*(1)		breast(1)|large_intestine(2)|lung(5)|stomach(1)	9				Epithelial(150;1.48e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0228)		AGGCTGGCCCGTAGGAGTACT	0.542000													12	67					6.72482e-11	8.33383e-11	0.479597	1	0
LRGUK	136332	broad.mit.edu	37	7	133876495	133876495	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:133876495G>T	ENST00000285928.2	+	12	1492	c.1423G>T	c.(1423-1425)Gtg>Ttg	p.V475L		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	475	Guanylate kinase-like.						ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						TGATGAAATGGTGAACATGGT	0.343000													19	39					1.22574e-08	1.42571e-08	0.624587	1	0
TTN	7273	broad.mit.edu	37	2	179595843	179595843	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:179595843T>G	ENST00000589042.1	-	60	17773	c.17549A>C	c.(17548-17550)aAg>aCg	p.K5850T	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.K4606T|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.K5533T|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5533	Ig-like 39.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATCTCCTTAGTCCCTGA	0.413000													26	63					0	0	0.717897	0	0
OR4A5	81318	broad.mit.edu	37	11	51412116	51412116	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:51412116C>G	ENST00000319760.6	-	1	332	c.280G>C	c.(280-282)Ggt>Cgt	p.G94R		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				CCCATGCAACCTTGGAAGGAA	0.453000													20	65					0	0	0.654019	0	0
GABRA4	2557	broad.mit.edu	37	4	46973237	46973237	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:46973237A>C	ENST00000264318.3	-	7	1719	c.737T>G	c.(736-738)aTg>aGg	p.M246R		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	246					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GTAAACCGTCATAACAATATA	0.368000													17	82					0	0	0.608945	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33684113	33684113	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:33684113C>G	ENST00000504830.1	-	4	1017	c.682G>C	c.(682-684)Gag>Cag	p.E228Q	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.E228Q	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	228					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TTGTGCCTCTCCCACTTCTCC	0.468000										HNSCC(64;0.19)			7	81					0	0	0.335167	0	0
ZNF626	199777	broad.mit.edu	37	19	20829185	20829185	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:20829185G>T	ENST00000601440.1	-	2	176	c.30C>A	c.(28-30)gcC>gcA	p.A10A	ZNF626_ENST00000291750.6_Silent_p.A10A|CTC-513N18.7_ENST00000595094.1_lincRNA	NM_001076675.2	NP_001070143.1	Q68DY1	ZN626_HUMAN	zinc finger protein 626	10	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|lung(3)|skin(1)	6						AGAATTCTATGGCCACATCTC	0.418000													77	116					3.01496e-42	5.28053e-42	0.870114	1	0
SLC16A5	9121	broad.mit.edu	37	17	73096237	73096237	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:73096237G>T	ENST00000450736.2	+	4	894	c.479G>T	c.(478-480)cGc>cTc	p.R160L	SLC16A5_ENST00000329783.4_Missense_Mutation_p.R160L|SLC16A5_ENST00000538213.2_Missense_Mutation_p.R200L|SLC16A5_ENST00000580123.1_Missense_Mutation_p.R160L			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	160					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	CTGCTCTCCCGCTACCTTCTG	0.652000													18	34					0.00074312	0.000779119	0.539581	1	0
PILRB	29990	broad.mit.edu	37	7	99956460	99956460	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:99956460G>C	ENST00000310771.4	+	16	2708	c.212G>C	c.(211-213)tGg>tCg	p.W71S	PILRB_ENST00000452089.1_Missense_Mutation_p.W71S|PILRB_ENST00000448382.1_Intron|PILRB_ENST00000444073.1_Missense_Mutation_p.W71S|PILRB_ENST00000444874.1_Intron			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	71	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity	p.W71*(1)		endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					AGAATATCCTGGAGACGGGGC	0.537000													58	59					0	0	0.870114	0	0
ZNF329	79673	broad.mit.edu	37	19	58640001	58640001	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:58640001T>C	ENST00000598312.1	-	4	1103	c.870A>G	c.(868-870)ctA>ctG	p.L290L	ZNF329_ENST00000358067.4_Silent_p.L290L	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		TTCCACACTCTAGGCATTCAT	0.428000													37	92					0	0	0.870114	0	0
OR52E2	119678	broad.mit.edu	37	11	5080175	5080175	+	Missense_Mutation	SNP	C	C	A	rs141087990		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:5080175C>A	ENST00000321522.2	-	1	682	c.683G>T	c.(682-684)cGt>cTt	p.R228L		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		AGTAGGAAGACGGAAAACAGC	0.398000													26	26					7.01153e-11	8.67141e-11	0.717897	1	0
ROR2	4920	broad.mit.edu	37	9	94486482	94486482	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:94486482C>T	ENST00000375708.3	-	9	2492	c.2294G>A	c.(2293-2295)aGc>aAc	p.S765N	ROR2_ENST00000375715.1_Missense_Mutation_p.S625N|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	765	Ser/Thr-rich.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CGTGGTGTTGCTGGCCCCCGA	0.672000													29	44					0	0	0.740014	0	0
PLXNA4	91584	broad.mit.edu	37	7	131887442	131887442	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:131887442C>A	ENST00000359827.3	-	12	3511	c.2549G>T	c.(2548-2550)gGt>gTt	p.G850V	PLXNA4_ENST00000321063.4_Missense_Mutation_p.G850V			Q9HCM2	PLXA4_HUMAN	plexin A4	850	PSI 3.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCTTTTGGCACCAGACAGCTC	0.662000													18	67					9.95505e-16	1.35568e-15	0.624587	1	0
FAT4	79633	broad.mit.edu	37	4	126389779	126389779	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:126389779G>A	ENST00000394329.3	+	11	12025	c.12012G>A	c.(12010-12012)acG>acA	p.T4004T	FAT4_ENST00000335110.5_Silent_p.T2267T	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4004	Laminin G-like 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.T4004T(1)|p.T3969T(1)		NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AATTTGCCACGATTAAAAGTC	0.398000													10	35					0	0	0.387290	0	0
INSR	3643	broad.mit.edu	37	19	7125393	7125393	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:7125393G>A	ENST00000341500.5	-	16	3162	c.3123C>T	c.(3121-3123)cgC>cgT	p.R1041R	INSR_ENST00000302850.5_Silent_p.R1053R	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1053	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCACCGCCACGCGGGTCTCTG	0.597000													42	85					0	0	0.870114	0	0
DNAH11	8701	broad.mit.edu	37	7	21629011	21629011	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:21629011T>G	ENST00000328843.6	+	12	2190	c.2159T>G	c.(2158-2160)tTt>tGt	p.F720C	DNAH11_ENST00000409508.3_Missense_Mutation_p.F720C			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	720	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGTGTCAATTTTGACCCAAAG	0.299000									Kartagener syndrome				4	89					0	0	0.217242	0	0
TTC29	83894	broad.mit.edu	37	4	147824714	147824714	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:147824714G>T	ENST00000513335.1	-	7	845	c.646C>A	c.(646-648)Ctt>Att	p.L216I	TTC29_ENST00000398886.4_Missense_Mutation_p.L216I|TTC29_ENST00000325106.4_Missense_Mutation_p.L190I			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	190							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					TCGTAGAGAAGACCCATATGC	0.468000													12	16					4.75885e-15	6.39437e-15	0.520397	1	0
BCL9L	283149	broad.mit.edu	37	11	118772168	118772168	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:118772168C>A	ENST00000334801.3	-	6	3248	c.2284G>T	c.(2284-2286)Gac>Tac	p.D762Y	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	762	Met-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		ATGGGTGGGTCCACCTCCCTC	0.612000													9	24					2.17888e-05	2.36207e-05	0.335167	1	0
ASIC5	51802	broad.mit.edu	37	4	156751016	156751016	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:156751016C>A	ENST00000537611.2	-	10	1556	c.1510G>T	c.(1510-1512)Gag>Tag	p.E504*		NM_017419.2	NP_059115.1	Q9NY37	ACCN5_HUMAN	acid-sensing (proton-gated) ion channel family member 5	504						integral to membrane|plasma membrane											CATTAACACTCCTCTATCCTA	0.338000													3	15					6.4e-05	6.82817e-05	0.115264	1	0
ZNF287	57336	broad.mit.edu	37	17	16455877	16455877	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:16455877G>C	ENST00000395824.1	-	6	2196	c.1579C>G	c.(1579-1581)Caa>Gaa	p.Q527E	ZNF287_ENST00000395825.3_Missense_Mutation_p.Q527E			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	520					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TGTATTTTTTGATGCTGAAGA	0.353000													35	139					0	0	0.853193	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962506	73962506	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:73962506T>A	ENST00000373468.1	-	3	2537	c.1886A>T	c.(1885-1887)aAa>aTa	p.K629I	KIAA2022_ENST00000055682.5_Missense_Mutation_p.K629I			Q5QGS0	K2022_HUMAN	KIAA2022	629					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						AAGTTTAGATTTTCGTTTGCG	0.423000													4	24					0	0	0.150653	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004309	75004309	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:75004309C>A	ENST00000373359.2	-	1	770	c.578G>T	c.(577-579)cGa>cTa	p.R193L		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	193	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTCTCTTGCTCGGTTCCCATT	0.522000													14	46					1.02788e-11	1.29501e-11	0.520397	1	0
GABRB3	2562	broad.mit.edu	37	15	26793027	26793027	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:26793027C>T	ENST00000541819.2	-	10	1605	c.1503G>A	c.(1501-1503)gtG>gtA	p.V501V	GABRB3_ENST00000311550.5_Silent_p.V445V|GABRB3_ENST00000545868.1_Silent_p.V360V|GABRB3_ENST00000299267.4_Silent_p.V445V|GABRB3_ENST00000400188.3_Silent_p.V374V			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	445					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTATGGCATTCACATCGGTTA	0.448000													23	56					0	0	0.681144	0	0
BAI3	577	broad.mit.edu	37	6	69728376	69728376	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:69728376A>G	ENST00000370598.1	+	13	2913	c.2092A>G	c.(2092-2094)Atg>Gtg	p.M698V		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	698					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TTCATACTTAATGACTGGAAA	0.318000													26	29					0	0	0.760397	0	0
SCN1A	6323	broad.mit.edu	37	2	166866254	166866254	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:166866254G>T	ENST00000423058.2	-	20	3994	c.3977C>A	c.(3976-3978)gCc>gAc	p.A1326D	AC010127.3_ENST00000597623.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.A1298D|SCN1A_ENST00000303395.4_Missense_Mutation_p.A1326D|SCN1A_ENST00000375405.3_Missense_Mutation_p.A1315D	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1326			A -> P (in SMEI; dbSNP:rs121918803).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TCGAGATAAGGCTCTTAGAGG	0.363000													18	43					2.4624e-09	2.9088e-09	0.575678	1	0
SOX6	55553	broad.mit.edu	37	11	16071463	16071463	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:16071463G>T	ENST00000352083.6	-	11	1350	c.1273C>A	c.(1273-1275)Ctg>Atg	p.L425M	SOX6_ENST00000396356.3_Missense_Mutation_p.L425M|SOX6_ENST00000528252.1_Missense_Mutation_p.L384M|SOX6_ENST00000528429.1_Missense_Mutation_p.L425M|SOX6_ENST00000527619.1_Missense_Mutation_p.L387M|SOX6_ENST00000316399.6_Missense_Mutation_p.L425M			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	425					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						GAGAGATTCAGAGGCTGTGCT	0.443000													5	270					0.0381472	0.0388525	0.278610	1	0
HELLS	3070	broad.mit.edu	37	10	96333866	96333866	+	Silent	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:96333866A>G	ENST00000348459.5	+	8	732	c.627A>G	c.(625-627)ccA>ccG	p.P209P	HELLS_ENST00000239026.6_3'UTR|HELLS_ENST00000371332.4_Silent_p.P209P|HELLS_ENST00000394045.1_Silent_p.P209P|HELLS_ENST00000394044.1_Silent_p.P209P|HELLS_ENST00000394036.1_3'UTR	NM_018063.3	NP_060533.2	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	209					cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(4)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		ATGGTCAGCCAGTACCTTTTC	0.378000													58	92					0	0	0.870114	0	0
TNIK	23043	broad.mit.edu	37	3	170811640	170811640	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:170811640C>T	ENST00000436636.2	-	23	3053	c.2709G>A	c.(2707-2709)ttG>ttA	p.L903L	TNIK_ENST00000488470.1_Silent_p.L848L|TNIK_ENST00000470834.1_Silent_p.L866L|TNIK_ENST00000475336.1_Silent_p.L811L|TNIK_ENST00000460047.1_Silent_p.L840L|TNIK_ENST00000538048.1_Silent_p.L855L|TNIK_ENST00000369326.5_Silent_p.L881L|TNIK_ENST00000357327.5_Silent_p.L874L|TNIK_ENST00000341852.6_Silent_p.L819L|TNIK_ENST00000284483.8_Silent_p.L895L	NM_015028.2	NP_055843.1	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase	903	Mediates interaction with NEDD4.				actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(22)|ovary(5)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)	62	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			CTCTAATCATCAAGGTTCCTT	0.453000													64	109					0	0	0.870114	0	0
RASD2	23551	broad.mit.edu	37	22	35947909	35947909	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr22:35947909G>C	ENST00000216127.4	+	3	1273	c.631G>C	c.(631-633)Gcc>Ccc	p.A211P		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	211	Interaction with GNB1, GNB2 and GNB3.				locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						GTACGGTGACGCCTTCCACCC	0.632000													23	24					0	0	0.779181	0	0
POTEG	404785	broad.mit.edu	37	14	19573144	19573144	+	Splice_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:19573144G>T	ENST00000409832.3	+	8	1294	c.1242_splice	c.e8+1	p.K414_splice		NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	414								p.K414N(1)|p.K414K(1)		cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						GTGATAGAAAGGTATACTTTT	0.318000													16	75					1.96292e-10	2.38862e-10	0.592651	1	0
TMPRSS13	84000	broad.mit.edu	37	11	117789465	117789465	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:117789465G>C	ENST00000528626.1	-	2	183	c.110C>G	c.(109-111)gCc>gGc	p.A37G	TMPRSS13_ENST00000524993.1_Missense_Mutation_p.A37G|TMPRSS13_ENST00000526090.1_Missense_Mutation_p.A37G|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.A37G|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.A37G	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	37	12 X 5 AA repeats of A-S-P-A-[GLQR].|4 X 5 AA repeats of T-P-P-G-R.|Ala-rich.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		AGATGCCTGGGCTGGAGATGC	0.632000													3	70					0	0	0.115264	0	0
LRRC7	57554	broad.mit.edu	37	1	70460311	70460311	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:70460311T>A	ENST00000310961.5	+	12	1318	c.900T>A	c.(898-900)atT>atA	p.I300I	LRRC7_ENST00000035383.5_Silent_p.I295I|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	295						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCAATACAATTGGAAAGTAAG	0.313000													25	82					0	0	0.760397	0	0
PRG4	10216	broad.mit.edu	37	1	186276694	186276694	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:186276694G>A	ENST00000445192.2	+	7	1888	c.1843G>A	c.(1843-1845)Gag>Aag	p.E615K	PRG4_ENST00000367483.4_Missense_Mutation_p.E574K|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Missense_Mutation_p.E572K|PRG4_ENST00000367485.4_Missense_Mutation_p.E522K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	615	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						TACCCCCAAGGAGACTGCACC	0.657000													14	46					0	0	0.693898	0	0
SVEP1	79987	broad.mit.edu	37	9	113233662	113233662	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:113233662G>T	ENST00000401783.2	-	16	3316	c.2980C>A	c.(2980-2982)Ctg>Atg	p.L994M	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.L994M|SVEP1_ENST00000374469.1_Missense_Mutation_p.L971M	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	994					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CGCCCTCTCAGCACTGAGCCT	0.433000													7	17					0.000157383	0.000166738	0.278610	1	0
KDR	3791	broad.mit.edu	37	4	55976687	55976687	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:55976687C>A	ENST00000263923.4	-	9	1433	c.1138G>T	c.(1138-1140)Ggg>Tgg	p.G380W		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	380	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AGTACATGCCCCGCTTTAATT	0.398000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			15	54					1.33834e-09	1.59338e-09	0.557998	1	0
OLFM3	118427	broad.mit.edu	37	1	102312423	102312423	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:102312423C>T	ENST00000338858.5	-	1	106	c.107G>A	c.(106-108)aGg>aAg	p.R36K	OLFM3_ENST00000359814.3_Missense_Mutation_p.R36K|OLFM3_ENST00000370103.4_Intron|OLFM3_ENST00000462354.1_Intron			Q96PB7	NOE3_HUMAN	olfactomedin 3	36						extracellular region				breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(24)|ovary(3)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)	43		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AGTCGACAGCCTCGTGGTGTT	0.493000													60	9					0	0	0.870114	0	0
TPBG	7162	broad.mit.edu	37	6	83075281	83075281	+	Silent	SNP	G	G	T	rs142377093	by1000genomes	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:83075281G>T	ENST00000369750.3	+	2	1220	c.603G>T	c.(601-603)gcG>gcT	p.A201A	TPBG_ENST00000543496.1_Silent_p.A201A|TPBG_ENST00000535040.1_Silent_p.A201A			Q13641	TPBG_HUMAN	trophoblast glycoprotein	201					cell adhesion	integral to plasma membrane		p.A201A(1)		central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		TGGTGGTGGCGGCCCTGCTGG	0.672000													74	15					3.76287e-55	6.86837e-55	0.870114	1	0
MNDA	4332	broad.mit.edu	37	1	158812104	158812104	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:158812104A>G	ENST00000368141.4	+	2	422	c.161A>G	c.(160-162)aAa>aGa	p.K54R	MNDA_ENST00000491210.1_3'UTR	NM_002432.1	NP_002423.1	P41218	MNDA_HUMAN	myeloid cell nuclear differentiation antigen	54	DAPIN.				B cell receptor signaling pathway|cellular defense response|negative regulation of B cell proliferation|positive regulation of apoptosis|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(26)|ovary(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	all_hematologic(112;0.0378)					TTGATGGAAAAAAAGTTCCAA	0.338000													30	55					0	0	0.760397	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946434	16946434	+	RNA	SNP	C	C	T	rs367060		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:16946434C>T	ENST00000412962.1	-	0	1085																											CTCAGCCTTCCGCCGGGCCAG	0.672000													6	44					0	0	0.307466	0	0
DEFB125	245938	broad.mit.edu	37	20	76731	76731	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:76731T>C	ENST00000382410.2	+	2	144	c.144T>C	c.(142-144)ctT>ctC	p.L48L		NM_153325.2	NP_697020.2	Q8N687	DB125_HUMAN	defensin, beta 125	48					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			ACATACTTCTTTGTAGGAACA	0.358000													48	68					0	0	0.870114	0	0
H2BFWT	158983	broad.mit.edu	37	X	103268201	103268201	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:103268201C>A	ENST00000217926.5	-	1	58	c.32G>T	c.(31-33)cGg>cTg	p.R11L		NM_001002916.3	NP_001002916.2	Q7Z2G1	H2BWT_HUMAN	H2B histone family, member W, testis-specific	11					nucleosome assembly	nuclear membrane|nucleosome	DNA binding			breast(2)|endometrium(3)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	16						GGTTGTGGACCGGGGAAGCCG	0.607000													15	2					2.5808e-16	3.5464e-16	0.539581	1	0
B4GALNT4	338707	broad.mit.edu	37	11	379559	379559	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:379559G>T	ENST00000329962.6	+	15	2346	c.2346G>T	c.(2344-2346)ccG>ccT	p.P782P		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	782						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCGGCTGCCGGGAGCCCGCG	0.751000													6	5					0.0381472	0.0388525	0.278610	1	0
LOR	4014	broad.mit.edu	37	1	153234351	153234351	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:153234351G>T	ENST00000368742.3	+	2	983	c.926G>T	c.(925-927)tGg>tTg	p.W309L		NM_000427.2	NP_000418.2	P23490	LORI_HUMAN	loricrin	309					keratinization|peptide cross-linking	cornified envelope|cytoplasm|insoluble fraction|nucleoplasm	protein binding, bridging|structural constituent of cytoskeleton			lung(2)	2	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCGCCTACCTGGCCGTCCAAA	0.657000													7	12					1.61879e-10	1.97382e-10	0.411799	1	0
ASXL3	80816	broad.mit.edu	37	18	31323276	31323276	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:31323276C>G	ENST00000269197.5	+	12	3464	c.3464C>G	c.(3463-3465)tCg>tGg	p.S1155W		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATGGAAGGTTCGACTGGTGTC	0.498000													6	27					0	0	0.278610	0	0
FTSJ1	24140	broad.mit.edu	37	X	48339684	48339684	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:48339684A>T	ENST00000019019.2	+	8	851	c.422A>T	c.(421-423)aAc>aTc	p.N141I	FTSJ1_ENST00000456787.1_Missense_Mutation_p.N141I|FTSJ1_ENST00000496365.1_3'UTR|FTSJ1_ENST00000348411.2_Missense_Mutation_p.N141I|FTSJ1_ENST00000396894.4_Missense_Mutation_p.N4I	NM_177439.1	NP_803188.1	Q9UET6	RRMJ1_HUMAN	FtsJ RNA methyltransferase homolog 1 (E. coli)	141					RNA methylation|rRNA processing		methyltransferase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|lung(4)|skin(1)	7						CAGGCTCTGAACATTGCTACA	0.602000													7	15					0	0	0.248553	0	0
SAMD9	54809	broad.mit.edu	37	7	92731888	92731888	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:92731888A>T	ENST00000379958.2	-	3	3792	c.3523T>A	c.(3523-3525)Tat>Aat	p.Y1175N		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1175						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TTCACTTCATACTCTCTATCT	0.378000													80	182					0	0	0.870114	0	0
KDM4A	9682	broad.mit.edu	37	1	44133469	44133469	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:44133469G>T	ENST00000372396.3	+	9	1076	c.942G>T	c.(940-942)aaG>aaT	p.K314N		NM_014663.2	NP_055478.2	O75164	KDM4A_HUMAN	lysine (K)-specific demethylase 4A	314					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleolus	histone demethylase activity (H3-K36 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(13)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	37						ACATGGTGAAGATCTCCATGG	0.507000													58	48					2.59843e-28	4.19906e-28	0.870114	1	0
AGBL5	60509	broad.mit.edu	37	2	27280267	27280267	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:27280267G>T	ENST00000360131.4	+	9	1791	c.1632G>T	c.(1630-1632)ccG>ccT	p.P544P	AGBL5_ENST00000323064.8_Silent_p.P544P	NM_021831.5	NP_068603.4	Q8NDL9	CBPC5_HUMAN	ATP/GTP binding protein-like 5	544	Poly-Pro.				protein branching point deglutamylation|proteolysis	cytosol|nucleus	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	28	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCCCCGCCGGCTTTCCCCT	0.522000													146	67					2.10857e-94	3.93167e-94	0.870114	1	0
TSPAN2	10100	broad.mit.edu	37	1	115596034	115596034	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:115596034A>C	ENST00000369516.2	-	7	597	c.566T>G	c.(565-567)aTt>aGt	p.I189S	TSPAN2_ENST00000369514.2_Intron|TSPAN2_ENST00000491992.1_5'UTR|TSPAN2_ENST00000369515.2_Missense_Mutation_p.I164S	NM_005725.4	NP_005716.2	O60636	TSN2_HUMAN	tetraspanin 2	189						integral to membrane				central_nervous_system(1)|large_intestine(4)|lung(3)|pancreas(1)|prostate(1)	10	Lung SC(450;0.211)	all_cancers(81;2.9e-07)|all_epithelial(167;1.42e-06)|all_lung(203;6.72e-06)|Lung NSC(69;1.13e-05)|Acute lymphoblastic leukemia(138;0.191)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		GACAATTCCAATGAGCTGGAG	0.383000													20	36					0	0	0.693898	0	0
ZNF275	10838	broad.mit.edu	37	X	152613191	152613191	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:152613191G>C	ENST00000421401.3	+	4	1225	c.1048G>C	c.(1048-1050)Gca>Cca	p.A350P	ZNF275_ENST00000440091.1_Missense_Mutation_p.A380P|ZNF275_ENST00000370249.2_Missense_Mutation_p.A297P|ZNF275_ENST00000370251.2_Intron	NM_001080485.3	NP_001073954.3	A6NFS0	A6NFS0_HUMAN	zinc finger protein 275	266						intracellular	nucleic acid binding|zinc ion binding			endometrium(5)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCGGCCCTACGCATGCGGCGA	0.667000													23	3					0	0	0.667858	0	0
ZNF827	152485	broad.mit.edu	37	4	146686250	146686250	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:146686250T>A	ENST00000508784.1	-	13	3347	c.3120A>T	c.(3118-3120)atA>atT	p.I1040I	ZNF827_ENST00000379448.4_Silent_p.I1040I|ZNF827_ENST00000513320.1_Silent_p.I690I			Q17R98	ZN827_HUMAN	zinc finger protein 827	1040					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TGATGAGGTGTATCTGCAGAT	0.502000													28	50					0	0	0.760397	0	0
CHD4	1108	broad.mit.edu	37	12	6702590	6702590	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:6702590G>A	ENST00000309577.6	-	16	2669	c.2506C>T	c.(2506-2508)Cgc>Tgc	p.R836C	CHD4_ENST00000357008.2_Missense_Mutation_p.R836C|CHD4_ENST00000544484.1_Missense_Mutation_p.R833C|CHD4_ENST00000544040.1_Missense_Mutation_p.R829C			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	836	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ACCTTCATGCGGGAGGCCTTC	0.522000													41	134					0	0	0.870114	0	0
CACNA1F	778	broad.mit.edu	37	X	49084728	49084728	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:49084728G>T	ENST00000376265.2	-	7	1060	c.999C>A	c.(997-999)acC>acA	p.T333T	CACNA1F_ENST00000376251.1_Silent_p.T268T|CACNA1F_ENST00000323022.5_Silent_p.T333T	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	333					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	AGAGCACATCGGTCCAGCCTT	0.587000													16	60					4.14922e-12	5.29353e-12	0.500413	1	0
CTNNA2	1496	broad.mit.edu	37	2	80101428	80101428	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:80101428C>A	ENST00000466387.1	+	10	1536	c.812C>A	c.(811-813)aCg>aAg	p.T271K	CTNNA2_ENST00000402739.4_Missense_Mutation_p.T271K|CTNNA2_ENST00000496558.1_Missense_Mutation_p.T271K|CTNNA2_ENST00000541047.1_Missense_Mutation_p.T271K|CTNNA2_ENST00000361291.4_Missense_Mutation_p.T305K|CTNNA2_ENST00000540488.1_Missense_Mutation_p.T271K			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	271					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						AAGGGCCACACGGGCATCGGC	0.542000													20	58					2.98393e-07	3.37993e-07	0.639603	1	0
SYNRG	11276	broad.mit.edu	37	17	35930774	35930774	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:35930774C>A	ENST00000339208.6	-	10	1449	c.1309G>T	c.(1309-1311)Gct>Tct	p.A437S	SYNRG_ENST00000502449.2_Missense_Mutation_p.A359S|SYNRG_ENST00000394378.2_Missense_Mutation_p.A359S|SYNRG_ENST00000588194.1_5'UTR|SYNRG_ENST00000585472.1_Missense_Mutation_p.A358S|SYNRG_ENST00000345615.4_Missense_Mutation_p.A359S|SYNRG_ENST00000346661.4_Missense_Mutation_p.A437S|SYNRG_ENST00000591288.1_Intron	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	437					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CCACTAGAAGCCTGGGCTGCA	0.507000													16	48					5.35267e-07	6.01803e-07	0.557998	1	0
DST	667	broad.mit.edu	37	6	56393638	56393638	+	Splice_Site	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:56393638C>G	ENST00000370754.5	-	67	17587		c.e67+1		DST_ENST00000370788.2_Splice_Site|DST_ENST00000340834.4_Splice_Site|DST_ENST00000361203.3_Splice_Site|DST_ENST00000446842.2_Splice_Site|DST_ENST00000312431.6_Splice_Site|DST_ENST00000370769.4_Splice_Site|DST_ENST00000421834.2_Splice_Site|DST_ENST00000244364.6_Splice_Site			Q03001	DYST_HUMAN	dystonin						cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			AGATATCTCACCTGTGGTTTG	0.318000													2	7					0	0	0.115264	0	0
MYRIP	25924	broad.mit.edu	37	3	40223855	40223855	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:40223855G>T	ENST00000302541.6	+	9	1360	c.1018G>T	c.(1018-1020)Gat>Tat	p.D340Y	MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000539167.1_Missense_Mutation_p.D153Y|MYRIP_ENST00000396217.3_Missense_Mutation_p.D251Y|MYRIP_ENST00000444716.1_Missense_Mutation_p.D340Y|MYRIP_ENST00000425621.1_Missense_Mutation_p.D340Y	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	340	Myosin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		GGACAGGCTGGATGAAACAAG	0.532000													19	34					7.45023e-12	9.44526e-12	0.592651	1	0
CASS4	57091	broad.mit.edu	37	20	55027672	55027672	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:55027672C>A	ENST00000371336.3	+	5	1641	c.1440C>A	c.(1438-1440)caC>caA	p.H480Q	CASS4_ENST00000434344.1_Intron|CASS4_ENST00000360314.3_Missense_Mutation_p.H480Q	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	480					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						ATGCAATCCACAGGTCCACTG	0.498000													40	24					8.94452e-30	1.48098e-29	0.870114	1	0
ZSWIM4	65249	broad.mit.edu	37	19	13941589	13941589	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:13941589C>T	ENST00000254323.2	+	13	2884	c.2695C>T	c.(2695-2697)Cgc>Tgc	p.R899C	ZSWIM4_ENST00000440752.2_Missense_Mutation_p.R733C	NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	899							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			CTTAGGGGCACGCCGGGCCGC	0.697000													10	9					0	0	0.387290	0	0
CROCCP2	84809	broad.mit.edu	37	1	16946438	16946438	+	RNA	SNP	G	G	A	rs28392876	by1000genomes	TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:16946438G>A	ENST00000412962.1	-	0	1081																											GCCTTCCGCCGGGCCAGCAGC	0.672000													4	35					0	0	0.217242	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37421191	37421191	+	Silent	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:37421191A>C	ENST00000374660.1	+	4	465	c.366A>C	c.(364-366)ctA>ctC	p.L122L	ANKRD30A_ENST00000361713.1_Silent_p.L122L|ANKRD30A_ENST00000602533.1_Silent_p.L122L			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	178						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						CACTTTTACTATCCATAACGA	0.289000													32	61					0	0	0.819951	0	0
OR12D3	81797	broad.mit.edu	37	6	29342769	29342769	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:29342769A>G	ENST00000396806.3	-	1	299	c.296T>C	c.(295-297)cTa>cCa	p.L99P	OR5V1_ENST00000377154.1_Intron	NM_030959.2	NP_112221.1	Q9UGF7	O12D3_HUMAN	olfactory receptor, family 12, subfamily D, member 3	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)	23						GAAGAAGTGTAGCTGGGTGAT	0.473000													11	39					0	0	0.387290	0	0
ZCCHC16	340595	broad.mit.edu	37	X	111698527	111698527	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:111698527C>A	ENST00000340433.2	+	1	801	c.571C>A	c.(571-573)Ccc>Acc	p.P191T		NM_001004308.2	NP_001004308.2	Q6ZR62	ZCH16_HUMAN	zinc finger, CCHC domain containing 16	191							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27						ACTAGCTGATCCCAACCAGGA	0.473000													85	47					1.13981e-37	1.96788e-37	0.870114	1	0
SPATA17	128153	broad.mit.edu	37	1	217856609	217856609	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:217856609C>A	ENST00000366933.4	+	5	356	c.301C>A	c.(301-303)Cga>Aga	p.R101R		NM_138796.2	NP_620151.1	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	101	IQ 3.					cytoplasm	calmodulin binding			endometrium(1)|kidney(1)|large_intestine(9)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		GATTCAGAGACGATGGCGAGG	0.308000													50	113					8.52622e-23	1.29496e-22	0.870114	1	0
SLC27A3	11000	broad.mit.edu	37	1	153751292	153751292	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:153751292C>T	ENST00000271857.2	+	7	2721	c.1961C>T	c.(1960-1962)aCt>aTt	p.T654I	SLC27A3_ENST00000484014.1_3'UTR|SLC27A3_ENST00000368661.3_Missense_Mutation_p.T573I			Q5K4L6	S27A3_HUMAN	solute carrier family 27 (fatty acid transporter), member 3	573					fatty acid metabolic process	integral to membrane|mitochondrial membrane	ligase activity|nucleotide binding			NS(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	14	all_lung(78;6.47e-32)|Lung NSC(65;2.52e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTCTTCAACACTGGGGACCTG	0.552000													19	71					0	0	0.681144	0	0
COLQ	8292	broad.mit.edu	37	3	15507857	15507857	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:15507857G>A	ENST00000383788.5	-	12	930	c.805C>T	c.(805-807)Cca>Tca	p.P269S	COLQ_ENST00000603808.1_Missense_Mutation_p.P269S|COLQ_ENST00000383781.4_Missense_Mutation_p.P259S|COLQ_ENST00000435459.2_Missense_Mutation_p.P259S|COLQ_ENST00000383786.5_Missense_Mutation_p.P235S|COLQ_ENST00000383787.2_Missense_Mutation_p.P260S|COLQ_ENST00000383785.2_3'UTR	NM_005677.3	NP_005668.2	Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	269	Collagen-like 1.				acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft				endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						CCTGCAGGTGGGGGGCCTGGG	0.607000													21	4					0	0	0.681144	0	0
ATP8A2	51761	broad.mit.edu	37	13	26112177	26112177	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:26112177G>T	ENST00000381655.2	+	7	701	c.559G>T	c.(559-561)Gat>Tat	p.D187Y	ATP8A2_ENST00000255283.8_Missense_Mutation_p.D147Y	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	147					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCTTCCAGCAGATGTGGTCCT	0.463000													22	33					3.17567e-06	3.5182e-06	0.729181	1	0
RAP1GDS1	5910	broad.mit.edu	37	4	99337948	99337948	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:99337948G>T	ENST00000408927.3	+	8	929	c.816G>T	c.(814-816)gaG>gaT	p.E272D	RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.E273D|RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.E224D|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.E181D|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.E223D|RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.E273D	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	272							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GTCTACTAGAGATTGTTCAGC	0.358000			T	NUP98	T-ALL								23	35					3.6726e-16	5.03529e-16	0.667858	1	0
EFCAB13	124989	broad.mit.edu	37	17	45492281	45492281	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:45492281C>T	ENST00000331493.2	+	23	2901	c.2490C>T	c.(2488-2490)tcC>tcT	p.S830S	EFCAB13_ENST00000517484.1_Silent_p.S734S|CTD-2026D20.2_ENST00000523101.1_RNA	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		TCCAAAAGTCCAAGGGTAAGT	0.299000													5	21					0	0	0.248553	0	0
NTRK3	4916	broad.mit.edu	37	15	88690616	88690616	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:88690616C>A	ENST00000394480.1	-	6	735	c.414G>T	c.(412-414)cgG>cgT	p.R138R	NTRK3_ENST00000542733.2_Silent_p.R40R|NTRK3_ENST00000357724.2_Silent_p.R138R|NTRK3_ENST00000540489.2_Silent_p.R138R|NTRK3_ENST00000557856.1_Silent_p.R138R|NTRK3_ENST00000558676.1_Silent_p.R138R|NTRK3_ENST00000360948.2_Silent_p.R138R|NTRK3_ENST00000317501.3_Silent_p.R138R|NTRK3_ENST00000355254.2_Silent_p.R138R	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	138					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTGTGGTGAGCCGGTTACTTG	0.428000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			13	21					4.36969e-10	5.27497e-10	0.435327	1	0
ABLIM3	22885	broad.mit.edu	37	5	148620251	148620251	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:148620251G>T	ENST00000506113.1	+	13	1699	c.1217G>T	c.(1216-1218)gGc>gTc	p.G406V	ABLIM3_ENST00000356541.3_Intron|RP11-331K21.1_ENST00000512647.2_RNA|ABLIM3_ENST00000309868.7_Missense_Mutation_p.G406V|AC012613.2_ENST00000523176.1_RNA|ABLIM3_ENST00000508983.1_Intron|RP11-331K21.1_ENST00000522685.1_RNA|ABLIM3_ENST00000504238.1_Intron|ABLIM3_ENST00000326685.7_Intron			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	406					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGAGAGTGGCCGGAGCTCT	0.562000													43	70					2.5401e-28	4.11577e-28	0.870114	1	0
GIF	2694	broad.mit.edu	37	11	59604781	59604781	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:59604781C>T	ENST00000541311.1	-	6	896	c.662G>A	c.(661-663)tGc>tAc	p.C221Y	GIF_ENST00000257248.2_Missense_Mutation_p.C246Y			P27352	IF_HUMAN	gastric intrinsic factor (vitamin B synthesis)	246					cobalamin metabolic process|cobalamin transport|cobalt ion transport	apical plasma membrane|endosome|extracellular space|microvillus	cobalamin binding			large_intestine(4)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	17						AGTCTTCTTGCAGTTCCATTC	0.453000													17	49					0	0	0.557998	0	0
SOD2	6648	broad.mit.edu	37	6	160106032	160106032	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:160106032C>G	ENST00000538183.1	-	4	537	c.377G>C	c.(376-378)gGt>gCt	p.G126A	SOD2_ENST00000337404.4_Missense_Mutation_p.G87A|SOD2_ENST00000546087.1_Missense_Mutation_p.G80A|SOD2_ENST00000367055.4_Missense_Mutation_p.G126A|SOD2_ENST00000367054.2_Missense_Mutation_p.G87A|SOD2_ENST00000444946.2_Intron	NM_000636.2	NP_000627.2	P04179	SODM_HUMAN	superoxide dismutase 2, mitochondrial	126					age-dependent response to reactive oxygen species|negative regulation of neuron apoptosis|oxygen homeostasis|protein homotetramerization|regulation of transcription from RNA polymerase II promoter|release of cytochrome c from mitochondria|removal of superoxide radicals|vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure		manganese ion binding|superoxide dismutase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(3)|skin(1)	14		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.103)		OV - Ovarian serous cystadenocarcinoma(65;1.4e-18)|BRCA - Breast invasive adenocarcinoma(81;5.77e-06)		GTCAAAGGAACCAAAGTCACG	0.413000													10	13					0	0	0.361761	0	0
ZNF519	162655	broad.mit.edu	37	18	14106174	14106174	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:14106174C>T	ENST00000590202.1	-	3	517	c.365G>A	c.(364-366)aGa>aAa	p.R122K	ZNF519_ENST00000589498.1_Intron|ZNF519_ENST00000589203.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	122					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						CTGAAATATTCTATATTCTTT	0.323000													7	55					0	0	0.335167	0	0
PDIK1L	149420	broad.mit.edu	37	1	26441054	26441054	+	Silent	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:26441054C>T	ENST00000374271.4	+	3	542	c.255C>T	c.(253-255)tcC>tcT	p.S85S	PDIK1L_ENST00000374269.1_Silent_p.S85S	NM_001243532.1|NM_001243533.1|NM_152835.4	NP_001230461.1|NP_001230462.1|NP_690048.1	Q8N165	PDK1L_HUMAN	PDLIM1 interacting kinase 1 like	85	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity			large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	7		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00239)|all_lung(284;0.00366)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000735)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.015)|READ - Rectum adenocarcinoma(331;0.0649)		AAAAGATGTCCCACGGCTCTA	0.423000													29	35					0	0	0.804634	0	0
MYH8	4626	broad.mit.edu	37	17	10322315	10322315	+	Silent	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:10322315A>T	ENST00000403437.2	-	4	337	c.243T>A	c.(241-243)ccT>ccA	p.P81P	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	81	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						GAGGGTTCATAGGGAAGACTT	0.438000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				84	9					0	0	0.870114	0	0
SLC12A1	6557	broad.mit.edu	37	15	48541779	48541779	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:48541779G>A	ENST00000396577.3	+	14	1907	c.1692G>A	c.(1690-1692)ctG>ctA	p.L564L	SLC12A1_ENST00000380993.3_Silent_p.L564L|SLC12A1_ENST00000558405.1_Silent_p.L564L	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1	564					potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CAGCGGAACTGAACACCATTG	0.428000													20	38					0	0	0.654019	0	0
IL2	3558	broad.mit.edu	37	4	123377359	123377359	+	Splice_Site	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:123377359C>G	ENST00000226730.4	-	2	432		c.e2-1			NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2						anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity			endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		TCTTGTAATTCTAAGAAAGTA	0.269000			T	TNFRSF17	intestinal T-cell lymphoma								18	23					0	0	0.654019	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209001	140209001	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:140209001C>A	ENST00000529310.1	+	1	1439	c.1325C>A	c.(1324-1326)tCt>tAt	p.S442Y	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.S442Y|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAGCTTGTCTGTGGAGGTG	0.647000													42	61					2.74695e-27	4.38067e-27	0.870114	1	0
FLG	2312	broad.mit.edu	37	1	152275708	152275708	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:152275708C>A	ENST00000368799.1	-	3	11689	c.11654G>T	c.(11653-11655)aGa>aTa	p.R3885I	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3885	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGATGGTTTCTGGAAGCAGA	0.562000									Ichthyosis				28	130					2.14196e-07	2.44449e-07	0.717897	1	0
KEAP1	9817	broad.mit.edu	37	19	10610225	10610225	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:10610225T>C	ENST00000171111.5	-	2	1032	c.485A>G	c.(484-486)tAc>tGc	p.Y162C	KEAP1_ENST00000393623.2_Missense_Mutation_p.Y162C	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	162					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GTCGATCTGGTACATGACAGC	0.587000													37	59					0	0	0.870114	0	0
TSPAN16	26526	broad.mit.edu	37	19	11417406	11417406	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:11417406G>A	ENST00000316737.1	+	5	727	c.577G>A	c.(577-579)Gtg>Atg	p.V193M	CTC-510F12.4_ENST00000586356.1_RNA|TSPAN16_ENST00000592955.1_Missense_Mutation_p.V168M|TSPAN16_ENST00000590327.1_Missense_Mutation_p.V193M	NM_012466.2	NP_036598.1	Q9UKR8	TSN16_HUMAN	tetraspanin 16	193						integral to membrane				breast(1)|endometrium(3)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(2)|stomach(1)	12						CGGACGCGATGTGTCTCCAAA	0.473000													7	22					0	0	0.335167	0	0
FBN1	2200	broad.mit.edu	37	15	48784735	48784735	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:48784735C>A	ENST00000316623.5	-	24	3232	c.2777G>T	c.(2776-2778)tGt>tTt	p.C926F		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	926	EGF-like 14; calcium-binding.		C -> R (in MFS; enhances proteolytic degradation).		heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		AGTGTTAACACACAGGCCATT	0.348000													36	49					4.16155e-14	5.47049e-14	0.840704	1	0
MUC17	140453	broad.mit.edu	37	7	100676844	100676844	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:100676844G>A	ENST00000306151.4	+	3	2211	c.2147G>A	c.(2146-2148)aGc>aAc	p.S716N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	716	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity	p.S716N(1)		NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTTGACACCAGCACACCTGTG	0.493000													9	720					0	0	0.539581	0	0
LRP2	4036	broad.mit.edu	37	2	170092469	170092469	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:170092469A>T	ENST00000263816.3	-	29	5086	c.4801T>A	c.(4801-4803)Tgc>Agc	p.C1601S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1601					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTTAAGCCGCAGGGCCAGAAG	0.517000													15	53					0	0	0.479597	0	0
WNK3	65267	broad.mit.edu	37	X	54319407	54319407	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chrX:54319407C>A	ENST00000354646.2	-	10	2389	c.1951G>T	c.(1951-1953)Gtt>Ttt	p.V651F	WNK3_ENST00000375159.2_Missense_Mutation_p.V651F|WNK3_ENST00000375169.3_Missense_Mutation_p.V651F	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	651					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						ACAGGTAAAACAGTGGACTGA	0.408000													24	44					2.25844e-05	2.44395e-05	0.717897	1	0
IL1F10	84639	broad.mit.edu	37	2	113832822	113832822	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:113832822G>A	ENST00000393197.2	+	4	761	c.340G>A	c.(340-342)Gct>Act	p.A114T	IL1F10_ENST00000341010.2_Missense_Mutation_p.A114T|IL1F10_ENST00000337569.3_Missense_Mutation_p.A114T	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	114						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						CAGGCTTGAGGCTGCTGCCTG	0.592000													35	105					0	0	0.788014	0	0
RNF112	7732	broad.mit.edu	37	17	19316023	19316023	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:19316023A>C	ENST00000461366.1	+	3	523	c.308A>C	c.(307-309)cAg>cCg	p.Q103P	RNF112_ENST00000580109.1_3'UTR|CTB-187M2.2_ENST00000579897.1_RNA	NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	103							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						ATATGCAAGCAGAAGAGGGGC	0.647000													8	51					0	0	0.307466	0	0
TTN	7273	broad.mit.edu	37	2	179597723	179597723	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:179597723C>A	ENST00000589042.1	-	55	16404	c.16180G>T	c.(16180-16182)Ggc>Tgc	p.G5394C	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G4150C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G5077C|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5077	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCTTTGCCATCCTTAAAC	0.473000													8	27					3.86212e-05	4.13506e-05	0.361761	1	0
OR2W3	343171	broad.mit.edu	37	1	248059469	248059469	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:248059469C>A	ENST00000537741.1	+	3	838	c.581C>A	c.(580-582)gCc>gAc	p.A194D	OR2W3_ENST00000360358.3_Missense_Mutation_p.A194D			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCACTGTGGCCATCGAAGGC	0.602000													14	116					7.63091e-17	1.06063e-16	0.834066	1	0
MAP3K4	4216	broad.mit.edu	37	6	161455335	161455335	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:161455335C>G	ENST00000392142.4	+	2	345	c.197C>G	c.(196-198)tCt>tGt	p.S66C	MAP3K4_ENST00000366919.2_Missense_Mutation_p.S66C|MAP3K4_ENST00000366920.2_Missense_Mutation_p.S66C|MAP3K4_ENST00000348824.7_Missense_Mutation_p.S66C	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	66					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		AGTCCTGAATCTGATCTAGAA	0.433000													80	19					0	0	0.870114	0	0
GSDMC	56169	broad.mit.edu	37	8	130789753	130789753	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:130789753T>A	ENST00000276708.4	-	2	962	c.81A>T	c.(79-81)ctA>ctT	p.L27L		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	27						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						TGGCACTCAATAGGTATTTGA	0.393000													80	169					0	0	0.870114	0	0
FMO2	2327	broad.mit.edu	37	1	171154856	171154856	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:171154856G>A	ENST00000441535.1	+	2	121	c.4G>A	c.(4-6)Gca>Aca	p.A2T	FMO2_ENST00000209929.7_Missense_Mutation_p.A2T|FMO2_ENST00000529935.1_Intron|RP1-45C12.1_ENST00000455124.1_RNA	NM_001460.2	NP_001451.1	Q99518	FMO2_HUMAN	flavin containing monooxygenase 2 (non-functional)	2					drug metabolic process|NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|host cell microsome|integral to membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	22	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGAGCTGATGGCAAAGAAGGT	0.453000													34	121					0	0	0.834066	0	0
TBC1D28	254272	broad.mit.edu	37	17	18539789	18539789	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:18539789C>G	ENST00000345096.4	-	9	1318	c.619G>C	c.(619-621)Gtt>Ctt	p.V207L	TBC1D28_ENST00000405044.1_Missense_Mutation_p.V207L			Q2M2D7	TBC28_HUMAN	TBC1 domain family, member 28	207	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|large_intestine(5)|lung(2)|ovary(1)	9						GAAGTTGCAACACCCCCGAGA	0.537000													51	78					0	0	0.870114	0	0
MCC	4163	broad.mit.edu	37	5	112676389	112676389	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:112676389A>G	ENST00000408903.3	-	3	869	c.454T>C	c.(454-456)Tct>Cct	p.S152P	CTD-2201G3.1_ENST00000416046.2_RNA	NM_001085377.1	NP_001078846.1	P23508	CRCM_HUMAN	mutated in colorectal cancers	0					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane	protein binding|receptor activity			endometrium(4)|kidney(3)|large_intestine(15)|liver(2)|lung(8)|ovary(2)|pancreas(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		all_cancers(142;5.89e-08)|all_epithelial(76;3.57e-11)|all_lung(232;0.000605)|Lung NSC(810;0.000697)|Colorectal(10;0.00146)|Prostate(80;0.00174)|Ovarian(225;0.0175)|Breast(839;0.198)		OV - Ovarian serous cystadenocarcinoma(64;2.04e-54)|Epithelial(69;9.69e-49)|all cancers(49;6.25e-44)|COAD - Colon adenocarcinoma(37;0.0432)|Colorectal(14;0.0766)		CTGGCACCAGAGTCGTATTCC	0.557000													10	22					0	0	0.411799	0	0
DUSP27	92235	broad.mit.edu	37	1	167095964	167095964	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:167095964C>A	ENST00000361200.2	+	6	1762	c.1596C>A	c.(1594-1596)aaC>aaA	p.N532K	DUSP27_ENST00000443333.1_Missense_Mutation_p.N532K|DUSP27_ENST00000271385.5_Missense_Mutation_p.N532K|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	532					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						CCTTCTACAACTTCTGCAGCA	0.542000													39	99					1.7489e-18	2.50552e-18	0.859065	1	0
SH3BP2	6452	broad.mit.edu	37	4	2829391	2829391	+	Silent	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:2829391A>T	ENST00000442312.2	+	7	839	c.660A>T	c.(658-660)ggA>ggT	p.G220G	SH3BP2_ENST00000503393.2_Silent_p.G249G|SH3BP2_ENST00000452765.2_Silent_p.G192G|SH3BP2_ENST00000511747.1_Silent_p.G192G|SH3BP2_ENST00000515183.1_3'UTR|SH3BP2_ENST00000435136.2_Silent_p.G192G|SH3BP2_ENST00000356331.5_Silent_p.G192G	NM_001145855.1	NP_001139327.1	P78314	3BP2_HUMAN	SH3-domain binding protein 2	192					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CGGAGCCCGGAAGGCTTGAGG	0.682000									Cherubism				4	13					0	0	0.150653	0	0
AP1M2	10053	broad.mit.edu	37	19	10685704	10685704	+	Splice_Site	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:10685704C>T	ENST00000590923.1	-	10	1138	c.1053_splice	c.e10-1	p.G352_splice	AP1M2_ENST00000250244.6_Splice_Site_p.G350_splice			Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	350	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			endometrium(4)|large_intestine(1)|lung(1)|ovary(2)|urinary_tract(1)	9			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CTCCTTGCCCCCCTGAGGGAA	0.612000													6	5					0	0	0.307466	0	0
MYO15A	51168	broad.mit.edu	37	17	18022664	18022664	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:18022664G>T	ENST00000205890.5	+	2	888	c.550G>T	c.(550-552)Ggg>Tgg	p.G184W		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	184	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					CCTGCGGCCTGGGGGCCGGCT	0.706000													9	31					0.00829132	0.00855969	0.361761	1	0
XPO1	7514	broad.mit.edu	37	2	61753558	61753558	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:61753558C>A	ENST00000401558.2	-	3	952	c.225G>T	c.(223-225)acG>acT	p.T75T	XPO1_ENST00000406957.1_Silent_p.T75T|XPO1_ENST00000404992.2_Silent_p.T75T|XPO1_ENST00000481214.1_5'UTR	NM_003400.3	NP_003391.1	O14980	XPO1_HUMAN	exportin 1 (CRM1 homolog, yeast)	75	Importin N-terminal.|Necessary for HTLV-1 Rex-mediated mRNA export.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(5)|lung(5)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			TGCTTACTTTCGTATTCATAT	0.343000			Mis		CLL								9	30					0.000978159	0.00102377	0.387290	1	0
ABCA4	24	broad.mit.edu	37	1	94502771	94502771	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:94502771C>A	ENST00000370225.3	-	25	3829	c.3743G>T	c.(3742-3744)aGa>aTa	p.R1248I		NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1248					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTCCAGCTCTCTGAAAAGGCT	0.478000													71	42					2.72187e-29	4.47006e-29	0.870114	1	0
KCND3	3752	broad.mit.edu	37	1	112525148	112525148	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:112525148G>T	ENST00000369697.1	-	1	270	c.201C>A	c.(199-201)ggC>ggA	p.G67G	KCND3_ENST00000315987.2_Silent_p.G67G|KCND3_ENST00000302127.4_Silent_p.G67G			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	67						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TCTCCGTGCTGCCCAGCAGGG	0.607000													48	7					3.07002e-29	5.02819e-29	0.870114	1	0
AP3D1	8943	broad.mit.edu	37	19	2117251	2117251	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:2117251T>A	ENST00000355272.6	-	16	2035	c.1829A>T	c.(1828-1830)aAg>aTg	p.K610M	AP3D1_ENST00000345016.5_Missense_Mutation_p.K610M|AP3D1_ENST00000356926.4_Missense_Mutation_p.K519M|AP3D1_ENST00000350812.6_Missense_Mutation_p.K441M	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	610					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTTCTGGGCCTTGGGGGCCAC	0.617000													15	15					0	0	0.520397	0	0
NUP160	23279	broad.mit.edu	37	11	47857248	47857248	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:47857248C>A	ENST00000378460.2	-	7	1102	c.1056G>T	c.(1054-1056)atG>atT	p.M352I	NUP160_ENST00000532747.1_3'UTR|NUP160_ENST00000528071.1_Missense_Mutation_p.M238I|NUP160_ENST00000530326.1_Missense_Mutation_p.M238I	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	352					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						GGTAGAGTCCCATGGTGGGGG	0.453000													52	117					4.32865e-36	7.41006e-36	0.870114	1	0
DSG4	147409	broad.mit.edu	37	18	28968453	28968453	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:28968453G>T	ENST00000359747.4	+	4	369	c.340G>T	c.(340-342)Gtg>Ttg	p.V114L	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.V114L|RP11-534N16.1_ENST00000581452.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	114	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CATCACTTCAGTGGTAGACAG	0.368000													26	44					6.53348e-20	9.54045e-20	0.788014	1	0
LAMA5	3911	broad.mit.edu	37	20	60899535	60899535	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:60899535G>C	ENST00000252999.3	-	42	5671	c.5605C>G	c.(5605-5607)Cac>Gac	p.H1869D		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1869	Laminin EGF-like 17.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGGTCTGAGTGTCCATGGCAC	0.632000													13	26					0	0	0.500413	0	0
THBS1	7057	broad.mit.edu	37	15	39883424	39883424	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:39883424G>A	ENST00000260356.5	+	15	2451	c.2286G>A	c.(2284-2286)caG>caA	p.Q762Q		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	762					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	ACCCAGCTCAGTATGACTATG	0.473000													51	70					0	0	0.870114	0	0
LOC653786	653786	broad.mit.edu	37	16	22587946	22587946	+	RNA	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:22587946G>C	ENST00000550753.1	+	0	2421					NR_003676.2																						CTCTCCAGTCGTGGGGTCTTT	0.527000													19	48					0	0	0.769981	0	0
WDR64	128025	broad.mit.edu	37	1	241929585	241929585	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:241929585G>T	ENST00000366552.2	+	15	2190	c.1983G>T	c.(1981-1983)ttG>ttT	p.L661F	WDR64_ENST00000437684.2_Missense_Mutation_p.L661F	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	661										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			GATATAATTTGATAGCAGCTG	0.333000													20	91					7.68411e-24	1.18187e-23	0.729181	1	0
BAI1	575	broad.mit.edu	37	8	143560689	143560689	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:143560689G>T	ENST00000517894.1	+	8	2461	c.1567G>T	c.(1567-1569)Ggc>Tgc	p.G523C	BAI1_ENST00000323289.5_Missense_Mutation_p.G523C			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	523	TSP type-1 5.				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGCAGTGGATGGCAAGTGGCA	0.667000													45	13					3.31162e-33	5.55911e-33	0.870114	1	0
CHD4	1108	broad.mit.edu	37	12	6696924	6696924	+	Silent	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:6696924G>C	ENST00000309577.6	-	24	3820	c.3657C>G	c.(3655-3657)ctC>ctG	p.L1219L	CHD4_ENST00000357008.2_Silent_p.L1219L|CHD4_ENST00000540960.1_5'UTR|CHD4_ENST00000544484.1_Silent_p.L1216L|CHD4_ENST00000544040.1_Silent_p.L1212L			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1219					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TGCCAAATTTGAGGATATCAT	0.493000													29	102					0	0	0.788014	0	0
BCHE	590	broad.mit.edu	37	3	165547892	165547892	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:165547892A>T	ENST00000264381.3	-	2	1096	c.930T>A	c.(928-930)taT>taA	p.Y310*	BCHE_ENST00000540653.1_Intron	NM_000055.2	NP_000046.1	P06276	CHLE_HUMAN	butyrylcholinesterase	310					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(34)|ovary(4)|pancreas(2)|stomach(1)	55					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	AAGGAGTCCCATAGGGGACAA	0.393000													17	59					0	0	0.592651	0	0
NRXN1	9378	broad.mit.edu	37	2	50723170	50723170	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:50723170T>A	ENST00000404971.1	-	16	4402	c.3063A>T	c.(3061-3063)aaA>aaT	p.K1021N	NRXN1_ENST00000406859.3_Missense_Mutation_p.K981N|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000401669.2_Missense_Mutation_p.K981N|NRXN1_ENST00000401710.1_5'UTR|NRXN1_ENST00000406316.2_Missense_Mutation_p.K981N|NRXN1_ENST00000402717.3_Missense_Mutation_p.K973N|NRXN1_ENST00000405472.3_Missense_Mutation_p.K973N	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	981	Laminin G-like 5.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CATTGAGAGGTTTATTTGAGC	0.418000													5	30					0	0	0.217242	0	0
STX2	2054	broad.mit.edu	37	12	131283099	131283099	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:131283099C>A	ENST00000261653.6	-	9	923	c.757G>T	c.(757-759)Gct>Tct	p.A253S	STX2_ENST00000392373.2_Missense_Mutation_p.A253S	NM_001980.3	NP_001971.2	P32856	STX2_HUMAN	syntaxin 2	253	t-SNARE coiled-coil homology.				acrosome reaction|ectoderm development|intracellular protein transport|organ morphogenesis|signal transduction	basolateral plasma membrane|integral to membrane|microsome|soluble fraction	calcium-dependent protein binding|SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)	16	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.79e-06)|all cancers(50;5.27e-05)|Epithelial(86;5.29e-05)		TATTTGATAGCTTTTTTTGTT	0.338000													25	66					7.26314e-15	9.71626e-15	0.717897	1	0
FLG	2312	broad.mit.edu	37	1	152283566	152283566	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:152283566G>T	ENST00000368799.1	-	3	3831	c.3796C>A	c.(3796-3798)Cag>Aag	p.Q1266K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1266	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGATCCCTGGTGCCTGCTT	0.557000									Ichthyosis				197	372					1.75318e-83	3.2391e-83	0.870114	1	0
ZNF292	23036	broad.mit.edu	37	6	87968288	87968288	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:87968288G>T	ENST00000369577.3	+	8	4984	c.4941G>T	c.(4939-4941)ttG>ttT	p.L1647F	ZNF292_ENST00000339907.4_Missense_Mutation_p.L1642F	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	1647					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		CCCAAAACTTGGTAACAAGTG	0.378000													13	6					1.56452e-12	2.01295e-12	0.557998	1	0
AIRE	326	broad.mit.edu	37	21	45708262	45708262	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr21:45708262T>A	ENST00000291582.5	+	5	700	c.573T>A	c.(571-573)gcT>gcA	p.A191A		NM_000383.3	NP_000374.1	O43918	AIRE_HUMAN	autoimmune regulator	191	SAND.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|histone binding|transcription regulatory region DNA binding|translation regulator activity|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|skin(2)|urinary_tract(1)	14				Colorectal(79;0.0806)		TCCAGAGAGCTGTGGCCATGT	0.612000									Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy				30	60					0	0	0.827153	0	0
KLK2	3817	broad.mit.edu	37	19	51379989	51379989	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:51379989C>A	ENST00000325321.3	+	3	693	c.468C>A	c.(466-468)ggC>ggA	p.G156G	KLK2_ENST00000391810.2_Silent_p.G54G|KLK2_ENST00000358049.4_Silent_p.G156G			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	156	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		ACGCCTCAGGCTGGGGCAGCA	0.632000			T	ETV4	prostate								10	15					3.86212e-05	4.13506e-05	0.361761	1	0
RPL29	6159	broad.mit.edu	37	3	52029475	52029475	+	Translation_Start_Site	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:52029475C>T	ENST00000481629.1	-	2	35	c.3G>A	c.(1-3)atG>atA	p.M1I	RPL29_ENST00000479017.1_Start_Codon_SNP_p.M1I|RPL29_ENST00000495383.1_Start_Codon_SNP_p.M1I|RPL29_ENST00000475248.1_Start_Codon_SNP_p.M1I|RPL29_ENST00000294189.6_Start_Codon_SNP_p.M1I|RPL29_ENST00000466397.1_Start_Codon_SNP_p.M1I			P47914	RL29_HUMAN	ribosomal protein L29	1					embryo implantation|endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	heparin binding|protein binding|RNA binding|structural constituent of ribosome			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TGGACTTGGCCATGTCTGCAC	0.572000													21	43					0	0	0.693898	0	0
F5	2153	broad.mit.edu	37	1	169500026	169500026	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:169500026G>T	ENST00000367796.3	-	15	5422	c.5221C>A	c.(5221-5223)Cca>Aca	p.P1741T	F5_ENST00000367797.3_Missense_Mutation_p.P1736T			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1736	F5/8 type A 3.|Plastocyanin-like 5.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTACCTACTGGGTTCACAGCT	0.473000													22	75					2.39556e-15	3.23321e-15	0.639603	1	0
TRIM51HP	440041	broad.mit.edu	37	11	55065679	55065679	+	RNA	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:55065679G>T	ENST00000526016.1	-	0	29					NR_038174.2																						ACTGGGTCTAGGAAGTAGTTC	0.473000													4	60					0.0381472	0.0388525	0.278610	1	0
LPHN2	23266	broad.mit.edu	37	1	82456735	82456735	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:82456735A>G	ENST00000370728.1	+	25	4931	c.4286A>G	c.(4285-4287)aAt>aGt	p.N1429S	LPHN2_ENST00000271029.4_Missense_Mutation_p.N1401S|LPHN2_ENST00000370727.1_Missense_Mutation_p.N1401S|LPHN2_ENST00000370713.1_3'UTR|LPHN2_ENST00000394879.1_Missense_Mutation_p.N1431S|LPHN2_ENST00000370730.1_Missense_Mutation_p.N1386S|LPHN2_ENST00000319517.6_Missense_Mutation_p.N1373S|LPHN2_ENST00000359929.3_Missense_Mutation_p.N1373S|LPHN2_ENST00000469377.2_3'UTR|LPHN2_ENST00000370717.2_Missense_Mutation_p.N1444S|LPHN2_ENST00000370721.1_Missense_Mutation_p.N1354S|LPHN2_ENST00000370715.1_3'UTR|LPHN2_ENST00000335786.5_Missense_Mutation_p.N1386S|LPHN2_ENST00000370723.1_Missense_Mutation_p.N1431S|LPHN2_ENST00000370725.1_Missense_Mutation_p.N1444S			O95490	LPHN2_HUMAN	latrophilin 2	1429					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		agcaggggcaatagtgatggt	0.433000													8	13					0	0	0.278610	0	0
RYBP	23429	broad.mit.edu	37	3	72428487	72428487	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:72428487C>A	ENST00000477973.1	-	2	514	c.515G>T	c.(514-516)aGt>aTt	p.S172I		NM_012234.5	NP_036366.3	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	0	Interaction with E4TF1B.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			prostate(1)|upper_aerodigestive_tract(1)	2		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		TGCTTTTCAACTTTCTCCTTC	0.418000													48	12					5.85753e-14	7.68325e-14	0.870114	1	0
ITGB6	3694	broad.mit.edu	37	2	161030489	161030489	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:161030489C>A	ENST00000283249.2	-	5	992	c.755G>T	c.(754-756)tGt>tTt	p.C252F	ITGB6_ENST00000409967.2_Missense_Mutation_p.C252F|ITGB6_ENST00000428609.2_Missense_Mutation_p.C210F|ITGB6_ENST00000485635.1_5'UTR|ITGB6_ENST00000409872.1_Missense_Mutation_p.C252F			P18564	ITB6_HUMAN	integrin, beta 6	252	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|multicellular organismal development	integrin complex	receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23						GCATACCTTACACACAGCAGC	0.338000													6	109					1.12685e-05	1.2304e-05	0.307466	1	0
C12orf40	283461	broad.mit.edu	37	12	40076414	40076414	+	Splice_Site	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:40076414C>A	ENST00000324616.5	+	8	842	c.686_splice	c.e8-1	p.L230_splice	C12orf40_ENST00000405531.3_Splice_Site_p.L230_splice|C12orf40_ENST00000398716.1_Splice_Site_p.L153_splice	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	230										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ATCCCAAAGTCTAGGAAATAG	0.323000													11	27					1.08611e-07	1.24656e-07	0.387290	1	0
TRIP6	7205	broad.mit.edu	37	7	100466204	100466204	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:100466204G>T	ENST00000200457.4	+	4	811	c.451G>T	c.(451-453)Ggc>Tgc	p.G151C		NM_003302.2	NP_003293.2	Q15654	TRIP6_HUMAN	thyroid hormone receptor interactor 6	151					focal adhesion assembly|positive regulation of cell migration|regulation of transcription, DNA-dependent|release of cytoplasmic sequestered NF-kappaB|transcription, DNA-dependent	cytoplasm|cytoskeleton|focal adhesion|nucleus	identical protein binding|interleukin-1 receptor binding|kinase binding|thyroid hormone receptor binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|liver(1)|lung(5)	14	Lung NSC(181;0.041)|all_lung(186;0.0581)					TCCCTATGGGGGCCCCACTCC	0.682000													17	44					2.27731e-05	2.45998e-05	0.608945	1	0
KCNA1	3736	broad.mit.edu	37	12	5021397	5021397	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:5021397G>T	ENST00000382545.3	+	2	1960	c.853G>T	c.(853-855)Gcc>Tcc	p.A285S	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	285					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGGCGAGCAGGCCACCTCCCT	0.532000													51	42					1.19403e-26	1.87457e-26	0.870114	1	0
KRAS	3845	broad.mit.edu	37	12	25398282	25398282	+	Missense_Mutation	SNP	C	C	A	rs121913535		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:25398282C>A	ENST00000311936.3	-	2	228	c.37G>T	c.(37-39)Ggc>Tgc	p.G13C	KRAS_ENST00000556131.1_Missense_Mutation_p.G13C|KRAS_ENST00000256078.4_Missense_Mutation_p.G13C|KRAS_ENST00000557334.1_Missense_Mutation_p.G13C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	13			G -> D (in a breast carcinoma cell line and GASC; somatic mutation).|G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13C(213)|p.G13S(59)|p.G13R(43)|p.G12_G13insG(3)|p.G13N(1)|p.G13I(1)|p.G12_G13insA(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TTGCCTACGCCACCAGCTCCA	0.343000	G13C(MORCPR_LUNG)|G13C(NCIH1355_LUNG)|G13C(NCIH1734_LUNG)|G13C(TOV21G_OVARY)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			97	37					6.85551e-66	1.25512e-65	0.870114	1	0
CD5L	922	broad.mit.edu	37	1	157802987	157802987	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:157802987C>A	ENST00000368174.4	-	5	1130	c.1034G>T	c.(1033-1035)tGc>tTc	p.C345F		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	345	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CTCACCTGAGCAGATGACAGC	0.522000													102	217					9.9929e-72	1.83506e-71	0.870114	1	0
SLC7A8	23428	broad.mit.edu	37	14	23596461	23596461	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:23596461C>T	ENST00000316902.7	-	11	2258	c.1533G>A	c.(1531-1533)atG>atA	p.M511I	SLC7A8_ENST00000469263.1_3'UTR|SLC7A8_ENST00000422941.2_Missense_Mutation_p.M287I|SLC7A8_ENST00000529705.2_Missense_Mutation_p.M406I|SLC7A8_ENST00000453702.1_Missense_Mutation_p.M308I	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	511					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GCTGCTCCTCCATGTCCTCAT	0.617000													45	62					0	0	0.870114	0	0
ATP7B	540	broad.mit.edu	37	13	52585448	52585448	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:52585448G>C	ENST00000242839.4	-	1	182	c.26C>G	c.(25-27)aCa>aGa	p.T9R	ATP7B_ENST00000418097.2_Missense_Mutation_p.T9R|ATP7B_ENST00000448424.2_Missense_Mutation_p.T9R|ATP7B_ENST00000400366.3_Missense_Mutation_p.T9R|ATP7B_ENST00000400370.3_Missense_Mutation_p.T9R|ATP7B_ENST00000344297.5_Missense_Mutation_p.T9R	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	9					ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		TTCTCTGGCTGTGATCTGTCT	0.612000									Wilson disease				27	83					0	0	0.769981	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322414	79322414	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:79322414T>G	ENST00000428286.1	-	8	4899	c.3699A>C	c.(3697-3699)caA>caC	p.Q1233H	PRUNE2_ENST00000376718.3_Missense_Mutation_p.Q1592H			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1592					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTATTTCTACTTGGCCATCAG	0.398000													7	26					0	0	0.248553	0	0
CD300LG	146894	broad.mit.edu	37	17	41934471	41934471	+	Splice_Site	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:41934471G>T	ENST00000317310.4	+	6	873		c.e6-1		CD300LG_ENST00000377203.4_Splice_Site|CD300LG_ENST00000586233.1_Splice_Site|CD300LG_ENST00000539718.1_Splice_Site|CD300LG_ENST00000293396.8_Splice_Site	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g							apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity			central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		ATCTCTTTCAGCTCAACAGGC	0.587000													39	45					2.6238e-40	4.5822e-40	0.870114	1	0
NLRP10	338322	broad.mit.edu	37	11	7982275	7982275	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:7982275A>T	ENST00000328600.2	-	2	1045	c.884T>A	c.(883-885)cTg>cAg	p.L295Q		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	295	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CCTCAAAGCCAGGGGCCGGGT	0.537000													4	134					0	0	0.217242	0	0
RHBG	57127	broad.mit.edu	37	1	156352644	156352644	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:156352644G>T	ENST00000400992.2	+	8	1490	c.1122G>T	c.(1120-1122)gtG>gtT	p.V374V	RHBG_ENST00000255013.3_Silent_p.V337V|RHBG_ENST00000368249.1_Silent_p.V406V|RHBG_ENST00000368246.2_Silent_p.V406V|RHBG_ENST00000494874.1_3'UTR|RHBG_ENST00000451864.2_Silent_p.V328V			Q9H310	RHBG_HUMAN	Rh family, B glycoprotein (gene/pseudogene)	406					transepithelial ammonium transport	anchored to plasma membrane|basolateral plasma membrane|cytoplasmic vesicle membrane|integral to plasma membrane|spectrin-associated cytoskeleton	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					TTGCCTCTGTGGGCGGGGGCC	0.522000											OREG0013870	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	93	85					6.50375e-52	1.173e-51	0.870114	1	0
ITGA2	3673	broad.mit.edu	37	5	52353897	52353897	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:52353897A>T	ENST00000296585.5	+	10	1282	c.1139A>T	c.(1138-1140)cAa>cTa	p.Q380L		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	380					axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GAAATGTCACAAGTGGGATTC	0.363000													26	264					0	0	0.796494	0	0
OR6C76	390326	broad.mit.edu	37	12	55820793	55820793	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:55820793C>A	ENST00000328314.3	+	1	756	c.756C>A	c.(754-756)tgC>tgA	p.C252*		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	252					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						ATGGAAGCTGCATCTTCATGT	0.408000													10	55					0.38729	0.389217	0.387290	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33588885	33588885	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:33588885G>A	ENST00000504830.1	-	18	3019	c.2684C>T	c.(2683-2685)tCg>tTg	p.S895L	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.S810L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	895	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GCATGTCGCCGAGCATGCTTC	0.582000										HNSCC(64;0.19)	OREG0016553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	153					0	0	0.750413	0	0
OTUD4	54726	broad.mit.edu	37	4	146059006	146059006	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:146059006G>A	ENST00000454497.2	-	21	2863	c.2726C>T	c.(2725-2727)aCt>aTt	p.T909I	OTUD4_ENST00000447906.2_Missense_Mutation_p.T974I|OTUD4_ENST00000455611.2_Intron	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	973							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					AACAGGCACAGTTTCTCTCTC	0.463000													4	101					0	0	0.184627	0	0
SEMA4A	64218	broad.mit.edu	37	1	156142757	156142757	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:156142757C>A	ENST00000368285.3	+	11	1542	c.1275C>A	c.(1273-1275)ggC>ggA	p.G425G	SEMA4A_ENST00000368284.1_Silent_p.G293G|SEMA4A_ENST00000487358.1_3'UTR|SEMA4A_ENST00000355014.2_Silent_p.G425G|SEMA4A_ENST00000368282.1_Silent_p.G425G|SEMA4A_ENST00000368286.2_Silent_p.G293G	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	425	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					CAGCCCAGGGCCTTGATGGGC	0.572000													29	46					6.04164e-23	9.22226e-23	0.750413	1	0
HMCN1	83872	broad.mit.edu	37	1	185987359	185987359	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:185987359A>G	ENST00000271588.4	+	34	5574	c.5345A>G	c.(5344-5346)aAg>aGg	p.K1782R	HMCN1_ENST00000367492.2_Missense_Mutation_p.K1782R	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1782	Ig-like C2-type 15.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GATGGATTCAAGATTTTATTA	0.398000													45	149					0	0	0.870114	0	0
OTOF	9381	broad.mit.edu	37	2	26684593	26684593	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:26684593G>A	ENST00000272371.2	-	43	5630	c.5504C>T	c.(5503-5505)gCg>gTg	p.A1835V	OTOF_ENST00000338581.6_Missense_Mutation_p.A1068V|OTOF_ENST00000339598.3_Missense_Mutation_p.A1068V|OTOF_ENST00000403946.3_Missense_Mutation_p.A1835V|OTOF_ENST00000402415.3_Missense_Mutation_p.A1145V	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1835					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding	p.A1068V(1)|p.A1835V(1)		NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GAAGTGGTCCGCATCCCAGAT	0.622000													5	293					0	0	0.307466	0	0
ANKRD2	26287	broad.mit.edu	37	10	99342436	99342436	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:99342436G>T	ENST00000307518.5	+	8	1177	c.910G>T	c.(910-912)Gct>Tct	p.A304S	ANKRD2_ENST00000455090.1_Missense_Mutation_p.A244S|ANKRD2_ENST00000298808.5_Missense_Mutation_p.A271S|ANKRD2_ENST00000370655.1_Missense_Mutation_p.A277S			Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 (stretch responsive muscle)	304					muscle contraction|muscle organ development		structural constituent of muscle			breast(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|stomach(1)	7		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		CCTGCATGGGGCTGACATGAT	0.537000													52	74					1.08141e-31	1.80036e-31	0.870114	1	0
NFAT5	10725	broad.mit.edu	37	16	69680966	69680966	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr16:69680966G>T	ENST00000349945.1	+	5	1559	c.7G>T	c.(7-9)Ggt>Tgt	p.G3C	NFAT5_ENST00000354436.2_Missense_Mutation_p.G79C|NFAT5_ENST00000567239.1_Missense_Mutation_p.G97C|NFAT5_ENST00000432919.1_Missense_Mutation_p.G97C|NFAT5_ENST00000393742.2_Missense_Mutation_p.G3C|NFAT5_ENST00000566899.1_Missense_Mutation_p.G3C	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	79					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CTCCATGGGCGGTGCTTGCAG	0.507000													140	319					1.84797e-88	3.42468e-88	0.870114	1	0
SLC5A10	125206	broad.mit.edu	37	17	18916823	18916823	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr17:18916823G>A	ENST00000317977.6	+	9	1453	c.882G>A	c.(880-882)atG>atA	p.M294I	SLC5A10_ENST00000395645.3_Missense_Mutation_p.M361I|SLC5A10_ENST00000395642.1_Missense_Mutation_p.M294I|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000395643.2_Missense_Mutation_p.M334I|SLC5A10_ENST00000395647.2_Missense_Mutation_p.M377I			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	361					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						TGGAACTGATGCCCATCGGTG	0.662000													41	113					0	0	0.870114	0	0
PTPRM	5797	broad.mit.edu	37	18	8387193	8387193	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr18:8387193G>C	ENST00000332175.8	+	29	5166	c.4129G>C	c.(4129-4131)Gag>Cag	p.E1377Q	PTPRM_ENST00000444013.1_Missense_Mutation_p.E1164Q|PTPRM_ENST00000400060.4_Missense_Mutation_p.E1391Q|PTPRM_ENST00000400053.4_Missense_Mutation_p.E1315Q|PTPRM_ENST00000580170.1_Missense_Mutation_p.E1390Q	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1377	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				GTGGCAAGAGGAGTACAATGG	0.557000													13	54					0	0	0.575678	0	0
OR52E6	390078	broad.mit.edu	37	11	5862246	5862246	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:5862246C>A	ENST00000329322.5	-	1	881	c.882G>T	c.(880-882)ggG>ggT	p.G294G	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Silent_p.G298G	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGGTTCTGACCCCATAGATTA	0.423000													33	92					2.52991e-16	3.48437e-16	0.870114	1	0
HK3	3101	broad.mit.edu	37	5	176316701	176316701	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr5:176316701G>A	ENST00000292432.5	-	7	766	c.675C>T	c.(673-675)ggC>ggT	p.G225G		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	225	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCATCATGGTGCCCACTGTGT	0.587000													63	14					0	0	0.870114	0	0
CYP2W1	54905	broad.mit.edu	37	7	1024666	1024666	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:1024666C>A	ENST00000340150.6	+	3	272	c.250C>A	c.(250-252)Cgg>Agg	p.R84R	CYP2W1_ENST00000308919.7_Silent_p.R140R			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	140					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GGGCGTGGGCCGGGAGCCGGT	0.672000													10	29					2.27111e-07	2.57733e-07	0.411799	1	0
C1QB	713	broad.mit.edu	37	1	22987611	22987611	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:22987611C>A	ENST00000509305.1	+	3	834	c.488C>A	c.(487-489)cCc>cAc	p.P163H	C1QB_ENST00000314933.6_Missense_Mutation_p.P165H			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	165	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TGCAAGGTGCCCGGTCTCTAC	0.597000													32	65					8.4185e-14	1.10186e-13	0.760397	1	0
RPE65	6121	broad.mit.edu	37	1	68904730	68904730	+	Missense_Mutation	SNP	T	T	G	rs61752902		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:68904730T>G	ENST00000262340.5	-	9	946	c.893A>C	c.(892-894)aAg>aCg	p.K298T		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	298					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						ATTGAGGTACTTTTTCCTTTT	0.333000													3	46					0	0	0.115264	0	0
MAFB	9935	broad.mit.edu	37	20	39317311	39317311	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:39317311G>A	ENST00000373313.2	-	1	569	c.180C>T	c.(178-180)ctC>ctT	p.L60L	MAFB_ENST00000396967.1_Silent_p.L60L	NM_005461.3	NP_005452.2	Q9Y5Q3	MAFB_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B	60					negative regulation of erythrocyte differentiation		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			kidney(1)|large_intestine(1)	2		Myeloproliferative disorder(115;0.00878)				ACGGAGTGCTGAGCGGTGTGG	0.657000			T	IGH@	MM								41	55					0	0	0.870114	0	0
NQO2	4835	broad.mit.edu	37	6	3012887	3012887	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:3012887G>T	ENST00000338130.2	+	7	994	c.282G>T	c.(280-282)gaG>gaT	p.E94D	NQO2_ENST00000380430.1_Missense_Mutation_p.E94D|NQO2_ENST00000380455.4_Missense_Mutation_p.E94D|NQO2_ENST00000380441.1_Missense_Mutation_p.E94D|NQO2_ENST00000380454.4_Missense_Mutation_p.E94D			P16083	NQO2_HUMAN	NAD(P)H dehydrogenase, quinone 2	94						cytoplasm|nucleus	coenzyme binding|dihydronicotinamide riboside quinone reductase activity|electron carrier activity|metal ion binding|NADPH dehydrogenase (quinone) activity			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|skin(1)	7	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Menadione(DB00170)|NADH(DB00157)	AGGTTCGGGAGGCTGACCTAG	0.388000													31	31					8.20599e-20	1.19539e-19	0.859065	1	0
GUSB	2990	broad.mit.edu	37	7	65447099	65447099	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:65447099C>A	ENST00000304895.4	-	1	202	c.72G>T	c.(70-72)caG>caT	p.Q24H	GUSB_ENST00000345660.6_Missense_Mutation_p.Q24H|GUSB_ENST00000421103.1_Missense_Mutation_p.Q24H	NM_000181.3	NP_000172.2	P08236	BGLR_HUMAN	glucuronidase, beta	24					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding			breast(1)|cervix(2)|kidney(2)|large_intestine(4)|lung(10)|skin(1)	20						GCATCCCGCCCTGCAGCCCCA	0.741000													3	11					0.004672	0.00483971	0.115264	1	0
DIO2	1734	broad.mit.edu	37	14	80677658	80677658	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr14:80677658C>G	ENST00000557010.1	-	3	543	c.158G>C	c.(157-159)cGc>cCc	p.R53P	DIO2_ENST00000555750.1_Missense_Mutation_p.R53P|DIO2_ENST00000422005.3_Missense_Mutation_p.R53P|DIO2_ENST00000438257.4_Missense_Mutation_p.R53P|DIO2_ENST00000557125.1_Intron	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	53					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		GGTCAGCATGCGCCGCCACTC	0.587000													39	8					0	0	0.870114	0	0
RHOD	29984	broad.mit.edu	37	11	66839000	66839000	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:66839000C>T	ENST00000308831.2	+	5	645	c.560C>T	c.(559-561)gCc>gTc	p.A187V	RHOD_ENST00000532559.1_Missense_Mutation_p.A121V	NM_014578.3	NP_055393.1	O00212	RHOD_HUMAN	ras homolog family member D	187					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity			lung(3)	3						CAGGAGGCCGCCGAGGTGGCC	0.701000													9	19					0	0	0.335167	0	0
KRT77	374454	broad.mit.edu	37	12	53086629	53086629	+	Silent	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:53086629T>C	ENST00000341809.3	-	6	1144	c.1116A>G	c.(1114-1116)ggA>ggG	p.G372G	RP11-641A6.3_ENST00000547533.1_RNA|KRT77_ENST00000537195.1_Silent_p.G139G	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	372	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TCAGGTCGTCTCCATGTCTCC	0.592000													27	28					0	0	0.804634	0	0
UBE3D	90025	broad.mit.edu	37	6	83732221	83732221	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:83732221C>T	ENST00000369747.3	-	7	919	c.797G>A	c.(796-798)aGc>aAc	p.S266N		NM_198920.1	NP_944602.1	Q7Z6J8	UB2CB_HUMAN	ubiquitin protein ligase E3D	266						cytoplasm	ligase activity										TCTAAAAGTGCTTCTAGCAGA	0.403000													11	30					0	0	0.539581	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74540461	74540461	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:74540461G>T	ENST00000354431.4	-	6	1072	c.881C>A	c.(880-882)cCt>cAt	p.P294H	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.P294H	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	294										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TAAATCAACAGGATAATATAT	0.269000													12	16					2.27111e-07	2.57733e-07	0.411799	1	0
LAMP3	27074	broad.mit.edu	37	3	182871802	182871802	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:182871802G>A	ENST00000265598.3	-	2	682	c.427C>T	c.(427-429)Cat>Tat	p.H143Y	LAMP3_ENST00000466939.1_Missense_Mutation_p.H119Y	NM_014398.3	NP_055213.2	Q9UQV4	LAMP3_HUMAN	lysosomal-associated membrane protein 3	143	Thr-rich.				cell proliferation	integral to membrane|lysosomal membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(9)|ovary(2)|prostate(2)	28	all_cancers(143;9.14e-14)|Ovarian(172;0.0355)		all cancers(12;2.91e-44)|Epithelial(37;5.52e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;4.16e-21)			CCAGTTGTATGAGCTGGTGGG	0.522000													72	135					0	0	0.870114	0	0
DUSP27	92235	broad.mit.edu	37	1	167096261	167096261	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:167096261G>C	ENST00000361200.2	+	6	2059	c.1893G>C	c.(1891-1893)gaG>gaC	p.E631D	DUSP27_ENST00000443333.1_Missense_Mutation_p.E631D|DUSP27_ENST00000271385.5_Missense_Mutation_p.E631D|DUSP27_ENST00000485151.1_Intron			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	631					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGCTGCTGGAGAGAAGCCGGC	0.627000													9	21					0	0	0.387290	0	0
DGKI	9162	broad.mit.edu	37	7	137266618	137266618	+	Silent	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:137266618T>A	ENST00000453654.1	-	15	1259	c.720A>T	c.(718-720)acA>acT	p.T240T	DGKI_ENST00000424189.2_Silent_p.T540T|DGKI_ENST00000288490.5_Silent_p.T540T|DGKI_ENST00000446122.1_Silent_p.T540T			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	540					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GGAACTCCAGTGTGACATGGG	0.443000													25	81					0	0	0.717897	0	0
BTN1A1	696	broad.mit.edu	37	6	26501822	26501822	+	Silent	SNP	C	C	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:26501822C>G	ENST00000244513.6	+	2	150	c.84C>G	c.(82-84)ccC>ccG	p.P28P		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	28	Ig-like V-type 1.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						CGGCAGCTCCCTTTGACGTGA	0.647000													18	47					0	0	0.608945	0	0
ARNT2	9915	broad.mit.edu	37	15	80767473	80767473	+	Silent	SNP	G	G	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:80767473G>A	ENST00000533983.1	+	6	837	c.498G>A	c.(496-498)gaG>gaA	p.E166E	ARNT2_ENST00000303329.4_Silent_p.E177E|ARNT2_ENST00000531595.3_3'UTR|ARNT2_ENST00000527771.1_Silent_p.E166E			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	177	PAS 1.				central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			CCCAGTCAGAGTGGTTTGGGA	0.517000													43	55					0	0	0.864702	0	0
KIR3DL1	3811	broad.mit.edu	37	19	55341667	55341667	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:55341667T>A	ENST00000391728.4	+	9	1305	c.1272T>A	c.(1270-1272)gaT>gaA	p.D424E	KIR3DL1_ENST00000326542.7_Missense_Mutation_p.D407E|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.D407E|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.D424E|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.D329E	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		CCCCTACAGATACCATCTTGT	0.517000													102	174					0	0	0.870114	0	0
SLMAP	7871	broad.mit.edu	37	3	57898350	57898350	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr3:57898350A>T	ENST00000295951.3	+	18	3057	c.1840A>T	c.(1840-1842)Aca>Tca	p.T614S	SLMAP_ENST00000442599.2_Missense_Mutation_p.T99S|SLMAP_ENST00000472546.1_3'UTR|SLMAP_ENST00000449503.2_Missense_Mutation_p.T593S|SLMAP_ENST00000428312.1_Missense_Mutation_p.T631S|SLMAP_ENST00000416870.1_Missense_Mutation_p.T124S|SLMAP_ENST00000295952.3_Missense_Mutation_p.T614S|SLMAP_ENST00000495364.1_Missense_Mutation_p.T165S|SLMAP_ENST00000494088.1_Missense_Mutation_p.T124S			Q14BN4	SLMAP_HUMAN	sarcolemma associated protein	631					muscle contraction|protein folding	integral to plasma membrane|microtubule organizing center|prefoldin complex|sarcolemma|smooth endoplasmic reticulum	unfolded protein binding			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(2)	18				BRCA - Breast invasive adenocarcinoma(55;0.000271)|KIRC - Kidney renal clear cell carcinoma(284;0.0602)|Kidney(284;0.0754)|OV - Ovarian serous cystadenocarcinoma(275;0.182)		GAAAGAAATCACAAGTCTGCA	0.433000													18	38					0	0	0.624587	0	0
IL26	55801	broad.mit.edu	37	12	68619400	68619400	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:68619400T>C	ENST00000229134.4	-	1	201	c.137A>G	c.(136-138)tAt>tGt	p.Y46C	IFNG-AS1_ENST00000536914.1_RNA	NM_018402.1	NP_060872.1	Q9NPH9	IL26_HUMAN	interleukin 26	46					cell-cell signaling|negative regulation of epithelial cell proliferation|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of JAK-STAT cascade|positive regulation of protein kinase B signaling cascade|positive regulation of stress-activated MAPK cascade|positive regulation of transcription from RNA polymerase II promoter	cytosol|extracellular space|soluble fraction	cytokine activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000515)		TGCTTTGATATAGAGAGCGTC	0.418000													69	174					0	0	0.870114	0	0
ASTN1	460	broad.mit.edu	37	1	176927594	176927594	+	Silent	SNP	G	G	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:176927594G>T	ENST00000367654.2	-	10	1660	c.1647C>A	c.(1645-1647)ggC>ggA	p.G549G	ASTN1_ENST00000424564.2_Silent_p.G541G|ASTN1_ENST00000361833.2_Silent_p.G541G|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000367657.3_Silent_p.G541G			O14525	ASTN1_HUMAN	astrotactin 1	549					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GCAACCACATGCCCTCCCCAA	0.547000													10	15					0.00136819	0.00142953	0.411799	1	0
DLGAP3	58512	broad.mit.edu	37	1	35370504	35370504	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:35370504C>A	ENST00000373347.1	-	3	749	c.481G>T	c.(481-483)Gag>Tag	p.E161*	DLGAP3_ENST00000235180.4_Nonsense_Mutation_p.E161*			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	161					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CTGCGGGGCTCTGGGGCAGTG	0.657000													35	18					2.19489e-29	3.61441e-29	0.819951	1	0
POU4F2	5458	broad.mit.edu	37	4	147560364	147560364	+	Silent	SNP	C	C	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:147560364C>A	ENST00000281321.3	+	1	320	c.72C>A	c.(70-72)ccC>ccA	p.P24P		NM_004575.2	NP_004566.2	Q12837	PO4F2_HUMAN	POU class 4 homeobox 2	24					estrogen receptor signaling pathway|MAPKKK cascade|negative regulation of transcription from RNA polymerase II promoter	nuclear speck	RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|breast(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)					ACGTGGAGCCCAAGTACTCGG	0.692000													10	10					1.61879e-10	1.97382e-10	0.411799	1	0
BTN3A2	11118	broad.mit.edu	37	6	26373136	26373136	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr6:26373136A>T	ENST00000356386.2	+	6	915	c.727A>T	c.(727-729)Agg>Tgg	p.R243W	BTN3A2_ENST00000527422.1_Missense_Mutation_p.R243W|BTN3A2_ENST00000396934.3_Missense_Mutation_p.R220W|BTN3A2_ENST00000508906.2_Missense_Mutation_p.R201W|BTN3A2_ENST00000532994.1_3'UTR|BTN3A2_ENST00000396948.1_Missense_Mutation_p.R243W|BTN3A2_ENST00000377708.2_Missense_Mutation_p.R243W	NM_001197246.2|NM_001197247.1|NM_007047.3	NP_001184175.1|NP_001184176.1|NP_008978.2	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2	243						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)	10						CCCCTTCTTCAGGAGCGCCCA	0.627000													54	48					0	0	0.870114	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887215	12887217	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:12887215_12887217delCTT	ENST00000535591.1	-	3	835_837	c.640_642delAAG	c.(640-642)del	p.K214del		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	214										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						TAACAATCTCCTTCTTCTGCTCT	0.512													54	150	---	---	---	---					
PADI4	23569	broad.mit.edu	37	1	17657545	17657546	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr1:17657545_17657546insA	ENST00000375448.4	+	2	200_201	c.174_175insA	c.(172-177)gcagaafs	p.E59fs	AC004824.2_ENST00000602074.1_Intron|PADI4_ENST00000375453.1_Frame_Shift_Ins_p.E59fs	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	59					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	GCCCTCCAGCCAAGAAGAAATC	0.604													60	56	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91893902	91893902	+	RNA	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr2:91893902delC	ENST00000436174.1	-	0	316																											GGCAAGTAATCTTCCTTCTGC	0.353													107	668	---	---	---	---					
TBC1D9	23158	broad.mit.edu	37	4	141592064	141592064	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr4:141592064delT	ENST00000442267.2	-	7	1150	c.1076delA	c.(1075-1077)agfs	p.K359fs		NM_015130.2	NP_055945.2	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	359	GRAM 2.					intracellular	calcium ion binding|Rab GTPase activator activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	31	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				GCTGTCTGCCTTTTCCACAAT	0.453													90	130	---	---	---	---					
AKR1B10	57016	broad.mit.edu	37	7	134222395	134222396	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:134222395_134222396insA	ENST00000359579.4	+	7	1043_1044	c.723_724insA	c.(721-726)caaaaafs	p.QK241fs		NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	241					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						CTGCAAAGCACAAAAAAACCGC	0.446													18	95	---	---	---	---					
TRBV6-7	28600	broad.mit.edu	37	7	142143970	142143970	+	RNA	DEL	G	G	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:142143970delG	ENST00000390373.2	-	0	49																											CAAAGCTGATGCTACAGCTCC	0.567													33	133	---	---	---	---					
TRBV5-3	28612	broad.mit.edu	37	7	142242736	142242736	+	RNA	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:142242736delC	ENST00000390362.1	-	0	11																											AGCAGAGGAGCCCGGGGCCCA	0.582													9	52	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149522379	149522379	+	RNA	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:149522379delC	ENST00000378016.2	+	0	14009							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGCTGCGAGGCCCAAGACACT	0.627													43	163	---	---	---	---					
PTPRN2	5799	broad.mit.edu	37	7	157959915	157959915	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr7:157959915delG	ENST00000389413.3	-	6	721	c.618delC	c.(616-618)ccfs	p.P206fs	PTPRN2_ENST00000389416.4_Frame_Shift_Del_p.P189fs|PTPRN2_ENST00000389418.4_Frame_Shift_Del_p.P206fs|PTPRN2_ENST00000404321.2_Frame_Shift_Del_p.P229fs|PTPRN2_ENST00000409483.1_Frame_Shift_Del_p.P168fs	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	206						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TCCGGGACCCGGGAGGGTAGG	0.632													36	72	---	---	---	---					
ZFHX4	79776	broad.mit.edu	37	8	77617546	77617547	+	Frame_Shift_Ins	INS	-	-	G	rs13252403		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:77617546_77617547insG	ENST00000521891.2	+	2	1671_1672	c.1223_1224insG	c.(1222-1224)cggfs	p.R408fs	ZFHX4_ENST00000455469.2_Frame_Shift_Ins_p.R408fs|ZFHX4_ENST00000050961.6_Frame_Shift_Ins_p.R408fs|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Frame_Shift_Ins_p.R408fs	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	408						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAAGTGAATCTGGGGGGGCTGT	0.535										HNSCC(33;0.089)			15	96	---	---	---	---					
ZFHX4	79776	broad.mit.edu	37	8	77765167	77765167	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr8:77765167delC	ENST00000521891.2	+	10	6458	c.6010delC	c.(6010-6012)ccfs	p.P2011fs	ZFHX4_ENST00000455469.2_Frame_Shift_Del_p.P1966fs|ZFHX4_ENST00000050961.6_Frame_Shift_Del_p.P1966fs|ZFHX4_ENST00000518282.1_Frame_Shift_Del_p.P1985fs	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1966	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGAAACGccgcccccgccacc	0.517										HNSCC(33;0.089)			10	3	---	---	---	---					
SPATA31D1	389763	broad.mit.edu	37	9	84606458	84606458	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr9:84606458delG	ENST00000344803.2	+	4	1120	c.1073delG	c.(1072-1074)tgfs	p.W359fs		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GAATTCACCTGGTGGCAGCCT	0.478													22	36	---	---	---	---					
POLR3A	11128	broad.mit.edu	37	10	79769363	79769364	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:79769363_79769364delCT	ENST00000372371.3	-	14	1977_1978	c.1840_1841delAG	c.(1840-1842)gfs	p.R614fs		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	614					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CAGGTTGGCCCTCACTGGATTG	0.574													225	100	---	---	---	---					
CUZD1	50624	broad.mit.edu	37	10	124594350	124594351	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr10:124594350_124594351insA	ENST00000368904.1	-	9	2202_2203	c.1253_1254insT	c.(1252-1254)taafs	p.*418fs	CUZD1_ENST00000545804.1_Frame_Shift_Ins_p.*418fs|CUZD1_ENST00000392790.1_Frame_Shift_Ins_p.*418fs			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	418	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane		p.L418L(1)		NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		GAGTTTGGTTCAAATCCACATA	0.386													12	16	---	---	---	---					
DCHS1	8642	broad.mit.edu	37	11	6651951	6651951	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:6651951delC	ENST00000299441.3	-	10	4485	c.4074delG	c.(4072-4074)gafs	p.E1358fs	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	1358	Cadherin 13.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CACCCGCGGGCTCTGGCGCTG	0.706													8	1	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65270058	65270059	+	RNA	INS	-	-	G			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:65270058_65270059insG	ENST00000534336.1	+	0	4826_4827					NR_002819.2																						TGTCTCTTAGAGGGTGGGCTTT	0.327													23	81	---	---	---	---					
MMP3	4314	broad.mit.edu	37	11	102713483	102713483	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:102713483delG	ENST00000299855.5	-	2	526	c.270delC	c.(268-270)ccfs	p.P90fs		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	90					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	CTCCACACCTGGGCTTGCGCA	0.507													21	28	---	---	---	---					
OR10G4	390264	broad.mit.edu	37	11	123886748	123886749	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:123886748_123886749insT	ENST00000320891.4	+	1	467_468	c.467_468insT	c.(466-468)ggtfs	p.G156fs		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		CTGCACTCTGCTGTCCAGACCA	0.574													82	95	---	---	---	---					
NFRKB	4798	broad.mit.edu	37	11	129739464	129739464	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr11:129739464delG	ENST00000446488.3	-	23	3559	c.3456delC	c.(3454-3456)ccfs	p.P1152fs	NFRKB_ENST00000304521.5_Frame_Shift_Del_p.P1152fs|NFRKB_ENST00000524794.1_Frame_Shift_Del_p.P1177fs|NFRKB_ENST00000524746.1_Frame_Shift_Del_p.P1152fs	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	1152					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TGATGCTGATGGGGGTGCTTG	0.577													24	56	---	---	---	---					
CNTN1	1272	broad.mit.edu	37	12	41318435	41318436	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:41318435_41318436insA	ENST00000551295.2	+	6	594_595	c.477_478insA	c.(475-480)gaccccfs	p.D159fs	CNTN1_ENST00000347616.1_Frame_Shift_Ins_p.D159fs|CNTN1_ENST00000360099.3_Frame_Shift_Ins_p.D159fs|CNTN1_ENST00000348761.2_Frame_Shift_Ins_p.D148fs|CNTN1_ENST00000547849.1_Frame_Shift_Ins_p.D159fs|CNTN1_ENST00000547702.1_Frame_Shift_Ins_p.D159fs	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	159	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane		p.P160T(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTCTCTGTGACCCCCCATACCA	0.381													16	83	---	---	---	---					
LOC101928617	101928617	broad.mit.edu	37	12	92579605	92579607	+	RNA	DEL	TCC	TCC	-	rs67662368		TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr12:92579605_92579607delTCC	ENST00000499685.2	+	0	1868_1870																											ctccccttcttcctcctcctcct	0.374													2	4	---	---	---	---					
DCLK1	9201	broad.mit.edu	37	13	36397008	36397008	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr13:36397008delC	ENST00000255448.4	-	11	1623	c.1412delG	c.(1411-1413)gafs	p.G471fs	DCLK1_ENST00000379893.1_Frame_Shift_Del_p.G164fs|DCLK1_ENST00000360631.3_Frame_Shift_Del_p.G471fs	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	471	Protein kinase.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		AAAAAGGTCTCCCCCCTGAGA	0.517													37	59	---	---	---	---					
BNIP2	663	broad.mit.edu	37	15	59971851	59971851	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:59971851delC	ENST00000267859.3	-	4	691	c.598delG	c.(598-600)agfs	p.E200fs	BNIP2_ENST00000415213.2_Frame_Shift_Del_p.E141fs|BNIP2_ENST00000607373.1_Frame_Shift_Del_p.E79fs			Q12982	BNIP2_HUMAN	BCL2/adenovirus E1B 19kDa interacting protein 2	79	CRAL-TRIO.				anti-apoptosis|apoptosis|positive regulation of muscle cell differentiation	nuclear envelope|perinuclear region of cytoplasm	calcium ion binding|GTPase activator activity|protein binding			NS(1)|large_intestine(2)|lung(5)|ovary(1)	9						AAGTCAATCTCCCCACTTTCA	0.383													16	25	---	---	---	---					
ANXA2	302	broad.mit.edu	37	15	60653163	60653163	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr15:60653163delA	ENST00000396024.3	-	6	493	c.334delT	c.(334-336)ctfs	p.S112fs	ANXA2_ENST00000332680.4_Frame_Shift_Del_p.S130fs|ANXA2_ENST00000421017.2_Frame_Shift_Del_p.S112fs|ANXA2_ENST00000451270.2_Frame_Shift_Del_p.S112fs	NM_001136015.2	NP_001129487.1	P07355	ANXA2_HUMAN	annexin A2	112					angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			kidney(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)	9					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	TTTAGCTCAGAAGCGTCATAC	0.423													17	17	---	---	---	---					
ZNF536	9745	broad.mit.edu	37	19	30936133	30936133	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr19:30936133delC	ENST00000355537.3	+	2	1811	c.1664delC	c.(1663-1665)gcfs	p.A555fs		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	555					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TTGGCAAACGCCGGGGTTCTG	0.537													44	79	---	---	---	---					
NSFL1C	55968	broad.mit.edu	37	20	1435763	1435763	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr20:1435763delC	ENST00000216879.4	-	4	1160	c.293delG	c.(292-294)gcfs	p.G98fs	RP4-776F14.3_ENST00000553571.1_RNA|NSFL1C_ENST00000476071.1_Frame_Shift_Del_p.G100fs|NSFL1C_ENST00000381658.4_Intron|NSFL1C_ENST00000350991.4_Frame_Shift_Del_p.G100fs|NSFL1C_ENST00000461211.1_5'UTR|NSFL1C_ENST00000353088.2_Frame_Shift_Del_p.G98fs	NM_016143.4	NP_057227.2	Q9UNZ2	NSF1C_HUMAN	NSFL1 (p97) cofactor (p47)	98						chromosome|Golgi stack|nucleus	lipid binding|protein binding			breast(1)|large_intestine(5)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	16						TCTCTCTGAGCCCCCAGCATA	0.488													114	208	---	---	---	---					
PI4KAP1	728233	broad.mit.edu	37	22	20394611	20394613	+	RNA	DEL	CTC	CTC	-			TCGA-55-8094-01A-11D-2238-08	TCGA-55-8094-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1e497004-9b23-4e0b-b5e6-2f756f23110f	80309912-c94c-440a-a83d-c689400802ab	g.chr22:20394611_20394613delCTC	ENST00000430523.3	-	0	582_584					NR_003563.1																						AGCCTGTGTTCTCCTCTACTAAC	0.547													11	28	---	---	---	---