Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BIRC7	79444	broad.mit.edu	37	20	61870856	61870856	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr20:61870856C>T	ENST00000217169.3	+	6	1010	c.796C>T	c.(796-798)Ccg>Tcg	p.P266S	BIRC7_ENST00000395306.1_Missense_Mutation_p.P161S|BIRC7_ENST00000342412.6_Missense_Mutation_p.P248S	NM_139317.1	NP_647478.1	Q96CA5	BIRC7_HUMAN	baculoviral IAP repeat containing 7	266					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)	12	all_cancers(38;2.72e-09)					CGTCTTTGTGCCGTGCGGCCA	0.701000													14	360					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829658	61829658	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr10:61829658G>A	ENST00000280772.1	-	37	11172	c.10981C>T	c.(10981-10983)Cag>Tag	p.Q3661*	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3661					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TCCCCTGACTGTGGCTGTGGT	0.522000													9	21					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84558925	84558925	+	Silent	SNP	T	T	C			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr15:84558925T>C	ENST00000286744.5	+	11	1361	c.1137T>C	c.(1135-1137)taT>taC	p.Y379Y	ADAMTSL3_ENST00000567476.1_Silent_p.Y379Y	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	379						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGACCATTATTGTCACTACT	0.413000													20	87					0	0	1	0	0
KRT24	192666	broad.mit.edu	37	17	38859674	38859674	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr17:38859674G>T	ENST00000264651.2	-	1	328	c.272C>A	c.(271-273)tCt>tAt	p.S91Y		NM_019016.2	NP_061889.2	Q2M2I5	K1C24_HUMAN	keratin 24	91	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00526)				GCCAAAGCTAGAACCCCCACC	0.567000													26	131					7.11191e-15	8.19415e-15	1	1	0
BIRC7	79444	broad.mit.edu	37	20	61870849	61870849	+	Silent	SNP	C	C	G			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr20:61870849C>G	ENST00000217169.3	+	6	1003	c.789C>G	c.(787-789)gtC>gtG	p.V263V	BIRC7_ENST00000395306.1_Silent_p.V158V|BIRC7_ENST00000342412.6_Silent_p.V245V	NM_139317.1	NP_647478.1	Q96CA5	BIRC7_HUMAN	baculoviral IAP repeat containing 7	263					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)	12	all_cancers(38;2.72e-09)					TGTCCATCGTCTTTGTGCCGT	0.697000													14	391					0	0	1	0	0
PET112	5188	broad.mit.edu	37	4	152609913	152609913	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr4:152609913G>T	ENST00000263985.6	-	10	1240	c.1200C>A	c.(1198-1200)aaC>aaA	p.N400K	PET112_ENST00000515812.1_Missense_Mutation_p.N359K	NM_004564.2	NP_004555.1	O75879	GATB_HUMAN	PET112 homolog (yeast)	400						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	23					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGCCGACTTCGTTCTGTTAAA	0.403000													9	48					0.000442599	0.00047873	1	1	0
DCAF6	55827	broad.mit.edu	37	1	167973797	167973797	+	Missense_Mutation	SNP	A	A	G	rs138263364		TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:167973797A>G	ENST00000367840.3	+	10	1238	c.1144A>G	c.(1144-1146)Act>Gct	p.T382A	DCAF6_ENST00000367843.3_Missense_Mutation_p.T382A|DCAF6_ENST00000432587.2_Missense_Mutation_p.T351A|DCAF6_ENST00000312263.6_Missense_Mutation_p.T382A	NM_001198956.1	NP_001185885.1	Q58WW2	DCAF6_HUMAN	DDB1 and CUL4 associated factor 6	382					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(8)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	36						AGatatttcaactcttcctac	0.368000													6	23					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81978960	81978960	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr7:81978960T>G	ENST00000356860.3	-	2	439	c.101A>C	c.(100-102)aAa>aCa	p.K34T	CACNA2D1_ENST00000423588.1_Missense_Mutation_p.K34T|CACNA2D1_ENST00000356253.5_Missense_Mutation_p.K34T	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	34						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CACCCATGATTTGATACTGCA	0.363000													23	109					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	470440	470440	+	Missense_Mutation	SNP	T	T	C	rs61730060		TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr20:470440T>C	ENST00000217244.3	-	10	1082	c.707A>G	c.(706-708)cAt>cGt	p.H236R	CSNK2A1_ENST00000460062.1_5'UTR|CSNK2A1_ENST00000349736.5_Missense_Mutation_p.H236R|CSNK2A1_ENST00000400217.1_Missense_Mutation_p.H100R|CSNK2A1_ENST00000400227.3_Missense_Mutation_p.H236R	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide	236	Protein kinase.				axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity	p.H236R(2)		autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			ATAATTGTCATGTCCATGGAA	0.373000													3	78					0	0	1	0	0
CYBRD1	79901	broad.mit.edu	37	2	172411171	172411171	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr2:172411171C>T	ENST00000321348.4	+	4	893	c.695C>T	c.(694-696)tCt>tTt	p.S232F	CYBRD1_ENST00000375252.3_3'UTR|CYBRD1_ENST00000409484.1_Missense_Mutation_p.S174F	NM_024843.3	NP_079119.3	Q53TN4	CYBR1_HUMAN	cytochrome b reductase 1	232					cellular iron ion homeostasis|electron transport chain|transmembrane transport	integral to membrane	ferric-chelate reductase activity|metal ion binding			endometrium(1)|kidney(1)|large_intestine(3)|liver(2)|lung(3)	10						GAGCCAAATTCTACCATTCTT	0.473000													17	18					0	0	1	0	0
WASH6P	653440	broad.mit.edu	37	X	155252868	155252868	+	RNA	SNP	T	T	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chrX:155252868T>A	ENST00000285718.7	+	0	819				WASH6P_ENST00000461007.1_RNA														p.P304P(5)									TAGCCGAGCCTCTCAAGGCAG	0.632000													3	15					0	0	1	0	0
SLC10A1	6554	broad.mit.edu	37	14	70252932	70252932	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr14:70252932A>T	ENST00000216540.4	-	2	582	c.449T>A	c.(448-450)cTg>cAg	p.L150Q		NM_003049.3	NP_003040.1	Q14973	NTCP_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 1	150					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)	14				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		CTTGTCCTTCAGGTCCCCATC	0.527000													6	126					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31273061	31273061	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr16:31273061C>T	ENST00000544665.3	+	2	148	c.77C>T	c.(76-78)aCc>aTc	p.T26I	ITGAM_ENST00000287497.8_Missense_Mutation_p.T26I	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	26					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						AACGCAATGACCTTCCAAGAG	0.522000													4	40					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27942236	27942236	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:27942236G>A	ENST00000374005.3	-	8	1090	c.802C>T	c.(802-804)Cgg>Tgg	p.R268W	FGR_ENST00000545953.1_Missense_Mutation_p.R202W|FGR_ENST00000399173.1_Missense_Mutation_p.R268W|FGR_ENST00000374004.1_Missense_Mutation_p.R268W	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	268	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GTGCCCAGCCGGCGCTCCAGC	0.701000													3	10					0	0	1	0	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													4	86					0	0	1	0	0
WDR88	126248	broad.mit.edu	37	19	33639806	33639806	+	Silent	SNP	C	C	T	rs144975503		TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr19:33639806C>T	ENST00000361680.2	+	5	747	c.669C>T	c.(667-669)tcC>tcT	p.S223S	WDR88_ENST00000355868.3_Silent_p.S223S			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	223								p.S223S(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					CCACCGTTTCCGTCATCAAAG	0.493000													11	46					0	0	1	0	0
CCT6P1	643253	broad.mit.edu	37	7	65222986	65222986	+	RNA	SNP	G	G	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr7:65222986G>T	ENST00000442266.1	+	0	578																											GAATTCTGGCGTTTTTTACAA	0.289000													2	6					0.0784	0.0784	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T|FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													4	67					0	0	1	0	0
KRT82	3888	broad.mit.edu	37	12	52790776	52790776	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr12:52790776A>G	ENST00000257974.2	-	6	1036	c.959T>C	c.(958-960)gTc>gCc	p.V320A	RP3-416H24.4_ENST00000547174.1_RNA	NM_033033.3	NP_149022.3	Q9NSB4	KRT82_HUMAN	keratin 82	320	Coil 2.|Rod.					keratin filament	protein binding|structural constituent of epidermis			endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	29				BRCA - Breast invasive adenocarcinoma(357;0.193)		CCCAGCTGTGACTCTCAGCTC	0.527000													11	50					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214638002	214638002	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:214638002C>T	ENST00000366956.5	-	2	339	c.145G>A	c.(145-147)Gct>Act	p.A49T	PTPN14_ENST00000543945.1_Missense_Mutation_p.A49T	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	49	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGGGCCACAGCCTCCAGGCAT	0.577000													8	58					0	0	1	0	0
NUP160	23279	broad.mit.edu	37	11	47808039	47808039	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr11:47808039G>A	ENST00000378460.2	-	32	3860	c.3814C>T	c.(3814-3816)Cag>Tag	p.Q1272*	NUP160_ENST00000530326.1_Nonsense_Mutation_p.Q1158*	NM_015231.1	NP_056046.1	Q12769	NU160_HUMAN	nucleoporin 160kDa	1272					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|biliary_tract(2)|breast(7)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(6)|prostate(2)|skin(2)|urinary_tract(2)	53						GATGAGAGCTGATTGGCTGCT	0.463000													10	68					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26881201	26881201	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:26881201C>T	ENST00000374168.2	+	9	882	c.728C>T	c.(727-729)gCg>gTg	p.A243V	RPS6KA1_ENST00000530003.1_Missense_Mutation_p.A227V|RPS6KA1_ENST00000531382.1_Missense_Mutation_p.A252V|RPS6KA1_ENST00000374166.4_Missense_Mutation_p.A243V|RPS6KA1_ENST00000526792.1_Missense_Mutation_p.A151V|RPS6KA1_ENST00000374162.2_Missense_Mutation_p.A151V	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	243	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		TCCCATAGTGCGGACTGGTGG	0.577000													43	281					0	0	1	0	0
FAM222B	55731	broad.mit.edu	37	17	27085514	27085514	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr17:27085514G>A	ENST00000341217.5	-	3	1678	c.1463C>T	c.(1462-1464)gCg>gTg	p.A488V	FAM222B_ENST00000581407.1_Missense_Mutation_p.A488V|FAM222B_ENST00000452648.3_Missense_Mutation_p.A488V|FAM222B_ENST00000582266.1_3'UTR	NM_018182.2	NP_060652.2	Q8WU58	CQ063_HUMAN	family with sequence similarity 222, member B	488																	GGGAGCTGCCGCACAGTCGAG	0.622000													3	80					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179526535	179526535	+	Silent	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr2:179526535C>T	ENST00000589042.1	-	180	37460	c.37236G>A	c.(37234-37236)aaG>aaA	p.K12412K	TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000591111.1_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10602							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGGCACTTTCTTTTCAAGGA	0.423000													12	65					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95665003	95665003	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr7:95665003G>A	ENST00000324972.6	+	13	1547	c.1354G>A	c.(1354-1356)Gtc>Atc	p.V452I	DYNC1I1_ENST00000537881.1_Missense_Mutation_p.V415I|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.V415I|DYNC1I1_ENST00000447467.2_Missense_Mutation_p.V435I|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.V432I|DYNC1I1_ENST00000457059.1_Missense_Mutation_p.V435I|DYNC1I1_ENST00000497626.1_3'UTR	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	452					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			AACGGGAGACGTCAATAACTT	0.468000													5	242					0	0	1	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172563762	172563762	+	Silent	SNP	A	A	G			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr2:172563762A>G	ENST00000358002.6	+	4	337	c.246A>G	c.(244-246)gtA>gtG	p.V82V	DYNC1I2_ENST00000409773.1_Intron|DYNC1I2_ENST00000409317.1_Intron|DYNC1I2_ENST00000410079.3_Silent_p.V82V|DYNC1I2_ENST00000409197.1_Intron|DYNC1I2_ENST00000397119.3_Intron|DYNC1I2_ENST00000340296.4_Intron|DYNC1I2_ENST00000263811.4_Intron|DYNC1I2_ENST00000534253.2_Intron|DYNC1I2_ENST00000409453.1_Intron|AC068039.1_ENST00000598148.1_Intron|DYNC1I2_ENST00000508530.1_Intron	NM_001271787.1	NP_001258716.1	Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	76					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			CTCTCCGTGTAGTAACAGCGG	0.368000													9	42					0	0	1	0	0
TOR1AIP1	26092	broad.mit.edu	37	1	179887122	179887122	+	Silent	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:179887122C>T	ENST00000435319.3	+	10	1691	c.1500C>T	c.(1498-1500)aaC>aaT	p.N500N	TOR1AIP1_ENST00000271583.3_Silent_p.N516N	NM_001267578.1|NM_015602.3	NP_001254507.1|NP_056417.2	Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1	500						integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						ACCATGAAAACGCGGCCTTCA	0.433000													14	78					0	0	1	0	0
RPL31P11	641311	broad.mit.edu	37	1	161654815	161654815	+	RNA	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:161654815C>T	ENST00000426558.1	-	0	227					NR_002595.1																						TATCAATGCGCGCATCTGGAG	0.507000													6	25					0	0	1	0	0
CNTNAP3B	728577	broad.mit.edu	37	9	43915893	43915893	+	Missense_Mutation	SNP	G	G	C	rs143747399	by1000genomes	TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr9:43915893G>C	ENST00000377564.3	+	23	4134	c.3741G>C	c.(3739-3741)atG>atC	p.M1247I		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	1247					cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						CTGCTGTCATGGGAGGTAACA	0.433000													3	34					0	0	1	0	0
MT-TL1	0	broad.mit.edu	37	MT	3244	3244	+	RNA	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chrM:3244G>A	ENST00000386347.1	+	0	15																											aagatggcagagcccggtaat	0.438000													3	30					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134074204	134074204	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr9:134074204G>A	ENST00000359428.5	+	29	5467	c.5323G>A	c.(5323-5325)Gcc>Acc	p.A1775T	NUP214_ENST00000451030.1_Missense_Mutation_p.A1776T|NUP214_ENST00000411637.2_Missense_Mutation_p.A1765T|NUP214_ENST00000483497.2_Missense_Mutation_p.A601T			P35658	NU214_HUMAN	nucleoporin 214kDa	1775	11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		CTTTGGTGCCGCCTCAAGTAC	0.557000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								4	89					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170063462	170063462	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr2:170063462A>C	ENST00000263816.3	-	39	7053	c.6768T>G	c.(6766-6768)gaT>gaG	p.D2256E		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2256					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTGCAATTATATCTAAAGAAT	0.438000													25	116					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105025696	105025696	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr8:105025696C>A	ENST00000507740.1	+	16	2749	c.2513C>A	c.(2512-2514)cCa>cAa	p.P838Q	RIMS2_ENST00000436393.2_Intron|RIMS2_ENST00000406091.3_Missense_Mutation_p.P1024Q|RIMS2_ENST00000262231.10_Missense_Mutation_p.P863Q	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1086	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GATAGACAGCCATATCACAGA	0.478000										HNSCC(12;0.0054)			8	59					0.00448238	0.00456858	1	1	0
SLIT2	9353	broad.mit.edu	37	4	20543236	20543236	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr4:20543236G>A	ENST00000504154.1	+	20	2389	c.2137G>A	c.(2137-2139)Gat>Aat	p.D713N	SLIT2_ENST00000273739.5_Missense_Mutation_p.D717N|SLIT2_ENST00000503823.1_Missense_Mutation_p.D705N|SLIT2_ENST00000503837.1_Missense_Mutation_p.D709N	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	713	LRRCT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CTTCACTTGTGATGACGGTAA	0.418000													17	72					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71319086	71319086	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr16:71319086T>A	ENST00000338099.5	-	3	1074	c.738A>T	c.(736-738)gaA>gaT	p.E246D	FTSJD1_ENST00000434935.2_Missense_Mutation_p.E246D			Q8IYT2	FTSJ1_HUMAN		246						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AAGCTTCTTGTTCACCTGGGT	0.413000													8	32					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186273248	186273248	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:186273248C>G	ENST00000445192.2	+	5	373	c.328C>G	c.(328-330)Ccc>Gcc	p.P110A	PRG4_ENST00000367484.3_Missense_Mutation_p.P69A|PRG4_ENST00000367486.3_Missense_Mutation_p.P110A|PRG4_ENST00000367485.4_Intron|PRG4_ENST00000367483.4_Missense_Mutation_p.P69A	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	110					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						AGTGCATAATCCCACATCACC	0.428000													16	74					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296555	39296555	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr17:39296555C>T	ENST00000345847.4	-	1	184	c.185G>A	c.(184-186)cGt>cAt	p.R62H		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	62	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament		p.R62H(2)		endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						gcagctgggacggcagcAGGT	0.667000													13	120					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32524972	32524972	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr21:32524972C>A	ENST00000286827.3	-	20	3819	c.3348G>T	c.(3346-3348)gaG>gaT	p.E1116D	TIAM1_ENST00000541036.1_Missense_Mutation_p.E1056D	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1116	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GATCAACCTTCTCAAGCTTTT	0.403000													17	82					8.10497e-08	8.94924e-08	1	1	0
BIRC7	79444	broad.mit.edu	37	20	61870753	61870753	+	Silent	SNP	T	T	C			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr20:61870753T>C	ENST00000217169.3	+	6	907	c.693T>C	c.(691-693)ctT>ctC	p.L231L	BIRC7_ENST00000395306.1_Intron|BIRC7_ENST00000342412.6_Intron	NM_139317.1	NP_647478.1	Q96CA5	BIRC7_HUMAN	baculoviral IAP repeat containing 7	231					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)	12	all_cancers(38;2.72e-09)					GGTGGGTTCTTGAGCCCCCAG	0.682000													9	296					0	0	1	0	0
KIAA1191	57179	broad.mit.edu	37	5	175782625	175782625	+	Silent	SNP	G	G	A			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr5:175782625G>A	ENST00000298569.4	-	4	689	c.156C>T	c.(154-156)agC>agT	p.S52S	KIAA1191_ENST00000393728.2_Intron|RP11-843P14.1_ENST00000512934.1_RNA|KIAA1191_ENST00000510164.1_Silent_p.S52S|KIAA1191_ENST00000393725.2_Silent_p.S33S|KIAA1191_ENST00000533553.1_Intron	NM_020444.3	NP_065177.2	Q96A73	K1191_HUMAN	KIAA1191	52							protein binding			endometrium(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6	all_cancers(89;0.00575)|Renal(175;0.000269)|Lung NSC(126;0.0105)|all_lung(126;0.0168)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.101)		TCCAAGGGACGCTGCCCATGT	0.582000													30	159					0	0	1	0	0
DNASE2	1777	broad.mit.edu	37	19	12989280	12989280	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr19:12989280C>T	ENST00000222219.3	-	5	717	c.625G>A	c.(625-627)Gaa>Aaa	p.E209K	DNASE2_ENST00000538460.1_Missense_Mutation_p.E154K	NM_001375.2	NP_001366.1	O00115	DNS2A_HUMAN	deoxyribonuclease II, lysosomal	209					apoptosis	lysosome	deoxyribonuclease II activity|DNA binding|protein binding			breast(1)|large_intestine(1)|lung(4)|ovary(1)	7						TTCCAGGGTTCTTGGCTAACG	0.532000													19	73					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100185475	100185475	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr10:100185475G>C	ENST00000325103.6	-	13	1391	c.1158C>G	c.(1156-1158)agC>agG	p.S386R	HPS1_ENST00000361490.4_Missense_Mutation_p.S386R|HPS1_ENST00000467246.1_5'UTR	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	386					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		GCGCGCTGGGGCTCTGAGGGT	0.672000									Hermansky-Pudlak syndrome		OREG0020430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	19					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88678414	88678414	+	Silent	SNP	G	G	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr15:88678414G>T	ENST00000394480.1	-	10	1443	c.1122C>A	c.(1120-1122)ggC>ggA	p.G374G	NTRK3_ENST00000540489.2_Silent_p.G374G|NTRK3_ENST00000557856.1_Silent_p.G374G|NTRK3_ENST00000355254.2_Silent_p.G374G|NTRK3_ENST00000317501.3_Silent_p.G374G|NTRK3_ENST00000360948.2_Silent_p.G374G|NTRK3_ENST00000558676.1_Silent_p.G374G|NTRK3_ENST00000357724.2_Silent_p.G374G|NTRK3_ENST00000542733.2_Silent_p.G276G	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	374	Ig-like C2-type 2.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGTATAGTTGCCATTGTTGT	0.542000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			4	116					0.00116845	0.00121427	1	1	0
OTOA	146183	broad.mit.edu	37	16	21693116	21693116	+	Silent	SNP	G	G	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr16:21693116G>T	ENST00000388958.3	+	5	238	c.237G>T	c.(235-237)cgG>cgT	p.R79R	OTOA_ENST00000286149.4_Silent_p.R79R	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	79					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		TGAATTCCCGGAATGTTGCCT	0.522000													12	101					0.000566183	0.000600154	1	1	0
ZAN	7455	broad.mit.edu	37	7	100349878	100349878	+	RNA	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr7:100349878C>T	ENST00000542585.1	+	0	2298				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane		p.P717L(2)		NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCAGAAAAACCCACCATCCCC	0.507000													3	110					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11024705	11024705	+	Silent	SNP	C	C	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr19:11024705C>T	ENST00000327064.4	+	6	1012	c.822C>T	c.(820-822)caC>caT	p.H274H	CARM1_ENST00000344150.4_Silent_p.H274H	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	274					cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						GCTACCTCCACGCCAAGAAGT	0.637000													8	22					0	0	1	0	0
SPDL1	54908	broad.mit.edu	37	5	169020446	169020446	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr5:169020446C>G	ENST00000265295.4	+	4	704	c.425C>G	c.(424-426)tCt>tGt	p.S142C	SPDL1_ENST00000510751.1_3'UTR	NM_017785.4	NP_060255.3			spindle apparatus coiled-coil protein 1																		GAACTCCTCTCTTGTAAATCA	0.428000													3	67					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47310359	47310360	+	RNA	INS	-	-	T			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr1:47310359_47310360insT	ENST00000505841.1	-	0	1269					NR_002788.2																						CAAAAACAAAACCCTAGATATT	0.421													4	8	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242466	55242480	+	In_Frame_Del	DEL	GAATTAAGAGAAGCA	GAATTAAGAGAAGCA	-	rs121913438		TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr7:55242466_55242480delGAATTAAGAGAAGCA	ENST00000275493.2	+	19	2413_2427	c.2236_2250delGAATTAAGAGAAGCA	c.(2236-2250)del	p.ELREA746del	EGFR_ENST00000454757.2_In_Frame_Del_p.ELREA693del|EGFR_ENST00000455089.1_In_Frame_Del_p.ELREA701del|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	746	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.K745_E749del(6)|p.E746_T751>V(6)|p.L747S(6)|p.E746_S752>A(6)|p.E746_T751>VA(6)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.K745_E746insVPVAIK(4)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746K(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.A750_E758>P(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.L747_K754>ST(1)|p.E746_A750>VP(1)|p.A750_K754del(1)|p.L747_P753del(1)|p.E746del(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.E749G(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.A750_E758del(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_A750del(1)|p.T751_E758del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCTATCAAGGAATTAAGAGAAGCAACATCTCCGA	0.474	E746K(HCC827_LUNG)|E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			8	65	---	---	---	---					
ROR2	4920	broad.mit.edu	37	9	94486026	94486028	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr9:94486026_94486028delTCC	ENST00000375708.3	-	9	2946_2948	c.2748_2750delGGA	c.(2746-2751)gaa>ga	p.EE916del	ROR2_ENST00000550066.1_5'UTR|ROR2_ENST00000375715.1_Intron	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	916					negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GACAGAGCCTTCCTCCTCCTCCT	0.645													7	142	---	---	---	---					
PLEKHA7	144100	broad.mit.edu	37	11	16822525	16822525	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr11:16822525delA	ENST00000355661.3	-	17	2415	c.2405delT	c.(2404-2406)tcfs	p.F802fs	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Frame_Shift_Del_p.F802fs|PLEKHA7_ENST00000448080.2_Frame_Shift_Del_p.F802fs			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	802					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GGTCACCTGGAAAAAAAAGGC	0.443													7	156	---	---	---	---					
DDX28	55794	broad.mit.edu	37	16	68056773	68056773	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr16:68056773delG	ENST00000332395.5	-	1	997	c.333delC	c.(331-333)cgfs	p.R111fs		NM_018380.3	NP_060850.2	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	111						mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		CCTGTTGCGCGCGCTCGATGG	0.687													2	4	---	---	---	---					
OCSTAMP	128506	broad.mit.edu	37	20	45174825	45174827	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr20:45174825_45174827delGCA	ENST00000279028.2	-	2	199_201	c.186_188delTGC	c.(184-189)gca>gc	p.AA62del		NM_080721.1	NP_542452.1	Q9BR26	CT123_HUMAN	osteoclast stimulatory transmembrane protein	62	Poly-Ala.					integral to membrane				breast(1)|endometrium(1)	2						AACCAGACCTGCAGCAGCAGCAG	0.621													2	4	---	---	---	---					
DOPEY2	9980	broad.mit.edu	37	21	37603391	37603391	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chr21:37603391delA	ENST00000399151.3	+	14	2394	c.2309delA	c.(2308-2310)gafs	p.E771fs		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	771					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CTGTCCGAGGAAGAGACCGAG	0.607													33	193	---	---	---	---					
AMOT	154796	broad.mit.edu	37	X	112022477	112022479	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-55-8206-01A-11D-2238-08	TCGA-55-8206-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a2c7551a-59c5-4a63-89a6-fbd4beb38789	a7ebb399-2a4a-4256-804e-0c3df50d7a00	g.chrX:112022477_112022479delCAG	ENST00000371959.3	-	10	2902_2904	c.2903_2905delCTG	c.(2902-2907)gtt>g	p.AV968del	AMOT_ENST00000304758.1_In_Frame_Del_p.AV559del|AMOT_ENST00000524145.1_In_Frame_Del_p.AV968del|AMOT_ENST00000371962.1_In_Frame_Del_p.AV736del	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	968					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						GCAACCTGAAcagcagcagcagc	0.616													2	4	---	---	---	---