Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCED1A	64773	broad.mit.edu	37	20	2819730	2819730	+	Splice_Site	SNP	T	T	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr20:2819730T>C	ENST00000360652.2	-	4	707		c.e4-2		PCED1A_ENST00000356872.3_Intron	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		CAGCTCCCCCTACCCACCCCC	0.652000													4	43					0	0	1	0	0
GZMH	2999	broad.mit.edu	37	14	25076910	25076910	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr14:25076910C>T	ENST00000216338.4	-	3	291	c.247G>A	c.(247-249)Gag>Aag	p.E83K	RP11-104E19.1_ENST00000557736.1_RNA|GZMH_ENST00000382548.4_Missense_Mutation_p.E83K|GZMH_ENST00000557220.2_Intron|RP11-104E19.1_ENST00000555300.1_RNA	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	83	Peptidase S1.				apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		TGGGTCCGCTCCTGTTCCTTG	0.537000													15	119					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84532697	84532697	+	RNA	SNP	T	T	G	rs145537028	by1000genomes	TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr9:84532697T>G	ENST00000527857.1	+	0	2719					NR_026851.1																						CCCAGGAGATTTCCTTCCTTA	0.438000													3	23					0	0	1	0	0
TSC1	7248	broad.mit.edu	37	9	135800990	135800990	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr9:135800990A>G	ENST00000298552.3	-	5	568	c.347T>C	c.(346-348)tTa>tCa	p.L116S	TSC1_ENST00000403810.1_Missense_Mutation_p.L116S|TSC1_ENST00000545250.1_Intron|TSC1_ENST00000475903.1_5'UTR|TSC1_ENST00000440111.2_Missense_Mutation_p.L116S	NM_000368.4|NM_001162426.1|NM_001162427.1	NP_000359.1|NP_001155898.1|NP_001155899.1	Q92574	TSC1_HUMAN	tuberous sclerosis 1	116					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding			NS(1)|bone(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(9)|lung(20)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	65				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		ACATTTTAGTAAAGAAGGCAA	0.403000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				23	27					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42695418	42695418	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr20:42695418C>G	ENST00000358131.5	+	7	1559	c.1351C>G	c.(1351-1353)Cct>Gct	p.P451A	TOX2_ENST00000435864.2_Missense_Mutation_p.P347A|TOX2_ENST00000423191.1_Missense_Mutation_p.P427A|TOX2_ENST00000341197.3_Missense_Mutation_p.P469A|TOX2_ENST00000372999.1_Missense_Mutation_p.P427A	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	451	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			ATCCTGCTCACCTGGCCCATC	0.637000													23	118					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73072158	73072158	+	RNA	SNP	T	T	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chrX:73072158T>C	ENST00000429829.1	-	0	430					NR_001564.2																						AAGGCAGGTATCCACGGCCCC	0.448000													6	6					0	0	1	0	0
OR13G1	441933	broad.mit.edu	37	1	247835492	247835492	+	Silent	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr1:247835492C>G	ENST00000359688.2	-	1	873	c.852G>C	c.(850-852)ccG>ccC	p.P284P	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGTACACCATCGGGTTTAATG	0.438000													21	75					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228855802	228855802	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr2:228855802G>A	ENST00000392056.3	-	11	4919	c.4873C>T	c.(4873-4875)Cga>Tga	p.R1625*	SPHKAP_ENST00000344657.5_Nonsense_Mutation_p.R1596*	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1625						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AGAGTGGCTCGGAGCTCGGCA	0.537000													13	40					0	0	1	0	0
PPP1R35	221908	broad.mit.edu	37	7	100033016	100033016	+	Silent	SNP	G	G	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr7:100033016G>C	ENST00000292330.2	-	4	919	c.729C>G	c.(727-729)ctC>ctG	p.L243L	PPP1R35_ENST00000476185.1_5'UTR|RP11-758P17.2_ENST00000492523.1_RNA	NM_145030.2	NP_659467.1	Q8TAP8	CG047_HUMAN	protein phosphatase 1, regulatory subunit 35	243																	TCCGGTGCATGAGGAAGGTGT	0.507000													17	50					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651666	96651666	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr6:96651666G>T	ENST00000302103.5	+	3	961	c.635G>T	c.(634-636)aGc>aTc	p.S212I		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	212					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		CTAAGCAAAAGCATTGAAATC	0.378000													4	32					0.00024832	0.000259781	1	1	0
CADPS	8618	broad.mit.edu	37	3	62385096	62385096	+	Silent	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr3:62385096G>A	ENST00000383710.4	-	30	4396	c.4047C>T	c.(4045-4047)gaC>gaT	p.D1349D	CADPS_ENST00000283269.9_Silent_p.D1310D|CADPS_ENST00000357948.3_Silent_p.D1270D	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	1349	Mediates targeting and association with DCVs (By similarity).				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding	p.D1310D(1)		breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CGTCTTCTTCGTCTTCCTCAT	0.493000													20	83					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63548012	63548012	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr18:63548012C>G	ENST00000397968.2	+	12	2666	c.2240C>G	c.(2239-2241)tCt>tGt	p.S747C	CDH7_ENST00000323011.3_Missense_Mutation_p.S747C	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	747					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				TCACTCAGCTCTTTAGATTCC	0.463000													9	73					0	0	1	0	0
KRT4	3851	broad.mit.edu	37	12	53207742	53207742	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr12:53207742G>T	ENST00000293774.4	-	1	593	c.323C>A	c.(322-324)tCc>tAc	p.S108Y	KRT4_ENST00000458244.2_Missense_Mutation_p.S34Y|KRT4_ENST00000551956.1_Missense_Mutation_p.S34Y			B4DRS2	B4DRS2_HUMAN	keratin 4	34						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						TCCAGACATGGAGACTGAGCT	0.602000													27	157					3.28513e-13	3.54585e-13	1	1	0
LRRC10	376132	broad.mit.edu	37	12	70004097	70004097	+	Silent	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr12:70004097G>A	ENST00000361484.3	-	1	845	c.522C>T	c.(520-522)ctC>ctT	p.L174L		NM_201550.2	NP_963844.2	Q5BKY1	LRC10_HUMAN	leucine rich repeat containing 10	174						nucleus				large_intestine(2)|lung(6)	8	all_cancers(2;2.83e-105)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;1.98e-18)|GBM - Glioblastoma multiforme(2;7.43e-12)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			GGTTGCCCGAGAGCCAGATGG	0.602000													7	69					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52536035	52536035	+	Silent	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr3:52536035C>T	ENST00000321725.6	+	4	421	c.345C>T	c.(343-345)ggC>ggT	p.G115G		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	115	EGF-like 1.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GCCCTGGGGGCGCTGAGACCC	0.647000													5	40					0	0	1	0	0
SNRNP200	23020	broad.mit.edu	37	2	96964641	96964641	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr2:96964641G>C	ENST00000323853.5	-	7	871	c.794C>G	c.(793-795)gCa>gGa	p.A265G	SNRNP200_ENST00000349783.5_Missense_Mutation_p.A265G	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	265						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CAGCCAAAATGCATCAATATC	0.468000													16	63					0	0	1	0	0
MMP20	9313	broad.mit.edu	37	11	102465485	102465485	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr11:102465485A>C	ENST00000260228.2	-	7	969	c.957T>G	c.(955-957)atT>atG	p.I319M	MMP20_ENST00000544938.1_5'UTR	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	319	Hemopexin-like 1.				proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		GTCTCCAGAAAATCCTATGGG	0.418000													5	25					0	0	1	0	0
PRSS37	136242	broad.mit.edu	37	7	141537820	141537820	+	Silent	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr7:141537820G>A	ENST00000350549.3	-	3	641	c.270C>T	c.(268-270)aaC>aaT	p.N90N	PRSS37_ENST00000438520.1_Silent_p.N90N	NM_001008270.2|NM_001171951.1	NP_001008271.2|NP_001165422.1	A4D1T9	PRS37_HUMAN	protease, serine, 37	90	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(3)	15						TATGACTGTAGTTCCAGTAGC	0.517000													26	126					0	0	1	0	0
CDH15	1013	broad.mit.edu	37	16	89245906	89245906	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr16:89245906G>A	ENST00000289746.2	+	2	190	c.125G>A	c.(124-126)cGc>cAc	p.R42H	CDH15_ENST00000521087.1_3'UTR	NM_004933.2	NP_004924.1	P55291	CAD15_HUMAN	cadherin 15, type 1, M-cadherin (myotubule)	42					adherens junction organization|cell junction assembly|homophilic cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	calcium ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.0261)		GCCCTGAGCCGCGTGCGGAGG	0.667000													8	105					0	0	1	0	0
NME7	29922	broad.mit.edu	37	1	169267939	169267939	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr1:169267939G>C	ENST00000367811.3	-	6	759	c.503C>G	c.(502-504)gCt>gGt	p.A168G	NME7_ENST00000472647.1_Missense_Mutation_p.A132G|NME7_ENST00000469474.1_5'UTR	NM_013330.3	NP_037462.1	Q9Y5B8	NDK7_HUMAN	NME/NM23 family member 7	168					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(8)|skin(1)	16	all_hematologic(923;0.208)					TTCACATATAGCATCATCTCT	0.408000													5	47					0	0	1	0	0
PELI3	246330	broad.mit.edu	37	11	66238754	66238754	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr11:66238754G>A	ENST00000349459.6	+	3	478	c.194G>A	c.(193-195)cGa>cAa	p.R65Q	PELI3_ENST00000524466.1_Missense_Mutation_p.R89Q|PELI3_ENST00000320740.7_Missense_Mutation_p.R89Q|PELI3_ENST00000531856.1_Intron	NM_001098510.1	NP_001091980.1	Q8N2H9	PELI3_HUMAN	pellino E3 ubiquitin protein ligase family member 3	89						cytosol	protein binding	p.R89Q(1)		breast(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)	15						GGCCGCCGGCGAAGCCGCCTG	0.597000													20	160					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25430615	25430615	+	RNA	SNP	G	G	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr15:25430615G>T	ENST00000424208.1	+	0	476					NR_003305.1																						GAAGAATTGCGTTAGGCCCTT	0.587000													7	34					0.00307968	0.00312564	1	1	0
UNC5D	137970	broad.mit.edu	37	8	35542149	35542149	+	Silent	SNP	C	C	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr8:35542149C>A	ENST00000453357.2	+	6	842	c.786C>A	c.(784-786)cgC>cgA	p.R262R	UNC5D_ENST00000420357.1_Intron|UNC5D_ENST00000404895.2_Silent_p.R267R|UNC5D_ENST00000287272.2_Intron|UNC5D_ENST00000416672.1_Silent_p.R267R			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	267	TSP type-1 1.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		GCAATGTTCGCTGTGGTAGAG	0.512000													8	80					3.09899e-07	3.29267e-07	1	1	0
ASZ1	136991	broad.mit.edu	37	7	117024807	117024807	+	Silent	SNP	C	C	T	rs143262073	byFrequency	TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr7:117024807C>T	ENST00000284629.2	-	6	722	c.660G>A	c.(658-660)gaG>gaA	p.E220E		NM_130768.2	NP_570124.1	Q8WWH4	ASZ1_HUMAN	ankyrin repeat, SAM and basic leucine zipper domain containing 1	220					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(3)|skin(1)	24	Lung NSC(10;0.00156)|all_lung(10;0.00175)		STAD - Stomach adenocarcinoma(10;0.000512)			TTTTTGCAATCTCACTTGGCA	0.338000													14	55					0	0	1	0	0
GCOM1	145781	broad.mit.edu	37	15	57910304	57910304	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr15:57910304C>G	ENST00000574161.1	+	3	355	c.236C>G	c.(235-237)tCa>tGa	p.S79*	MYZAP_ENST00000267853.5_Nonsense_Mutation_p.S79*|GCOM1_ENST00000380560.2_Nonsense_Mutation_p.S79*|GCOM1_ENST00000380569.2_Nonsense_Mutation_p.S79*|GCOM1_ENST00000572390.1_Nonsense_Mutation_p.S79*|GCOM1_ENST00000380568.3_Nonsense_Mutation_p.S79*|GCOM1_ENST00000380561.2_Nonsense_Mutation_p.S79*|GCOM1_ENST00000587652.1_Nonsense_Mutation_p.S79*|MYZAP_ENST00000380565.4_Nonsense_Mutation_p.S79*|GCOM1_ENST00000396180.1_Nonsense_Mutation_p.S79*|POLR2M_ENST00000380563.2_5'UTR	NM_001018100.3	NP_001018110.1	P0CAP1	GCOM1_HUMAN		79					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band				endometrium(1)|kidney(2)|large_intestine(9)|liver(1)|lung(1)|ovary(1)|skin(2)|stomach(1)	18						GTGCGAAGATCAGATCAAAAT	0.413000													8	52					0	0	1	0	0
FAR2	55711	broad.mit.edu	37	12	29474808	29474808	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr12:29474808C>T	ENST00000182377.4	+	10	1476	c.1208C>T	c.(1207-1209)aCg>aTg	p.T403M	FAR2_ENST00000547116.1_Missense_Mutation_p.T306M|FAR2_ENST00000536681.2_Missense_Mutation_p.T403M	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	403					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						GAATGGAGCACGTACAATACA	0.428000													12	58					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179459236	179459236	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr2:179459236C>G	ENST00000589042.1	-	296	58209	c.57985G>C	c.(57985-57987)Gag>Cag	p.E19329Q	TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E17688Q|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.E10389Q|TTN_ENST00000460472.2_Missense_Mutation_p.E10264Q|TTN_ENST00000342992.6_Missense_Mutation_p.E16761Q|TTN_ENST00000342175.6_Missense_Mutation_p.E10456Q|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17688	Fibronectin type-III 40.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGAACTTCTCAGTCCCAATG	0.378000													12	53					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72141583	72141583	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr16:72141583C>T	ENST00000268482.3	+	21	3358	c.2849C>T	c.(2848-2850)cCg>cTg	p.P950L	DHX38_ENST00000536867.1_Missense_Mutation_p.P262L	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	950					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.P950Q(1)		endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				GTGGAGTTCCCGCTGGACCCT	0.572000													30	177					0	0	1	0	0
USP53	54532	broad.mit.edu	37	4	120160999	120160999	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr4:120160999A>G	ENST00000450251.1	+	1	629	c.85A>G	c.(85-87)Acc>Gcc	p.T29A	USP53_ENST00000274030.6_Missense_Mutation_p.T29A			Q70EK8	UBP53_HUMAN	ubiquitin specific peptidase 53	29					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	27						ACTAGCCCCTACCAAAGGCTT	0.373000													7	26					0	0	1	0	0
LOC643201	643201	broad.mit.edu	37	5	175574097	175574097	+	RNA	SNP	A	A	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr5:175574097A>G	ENST00000515403.1	-	0	2671				RP11-826N14.4_ENST00000510029.1_lincRNA	NR_036494.1																						TCTTCTCCTGAGTCCTGAATC	0.423000													2	4					0	0	1	0	0
MXRA8	54587	broad.mit.edu	37	1	1289446	1289446	+	Missense_Mutation	SNP	C	C	T	rs150058708	byFrequency	TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr1:1289446C>T	ENST00000309212.6	-	8	1216	c.1186G>A	c.(1186-1188)Gac>Aac	p.D396N	MXRA8_ENST00000342753.4_Missense_Mutation_p.D295N|MXRA8_ENST00000445648.2_Missense_Mutation_p.D396N	NM_032348.2	NP_115724.1	Q9BRK3	MXRA8_HUMAN	matrix-remodelling associated 8	396						integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.77e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		AGCATCTGGTCCCCTGCAGCC	0.642000													5	73					0	0	1	0	0
KIAA1841	84542	broad.mit.edu	37	2	61298781	61298781	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr2:61298781C>T	ENST00000402291.1	+	4	432	c.191C>T	c.(190-192)tCg>tTg	p.S64L	KIAA1841_ENST00000356719.2_Missense_Mutation_p.S64L|KIAA1841_ENST00000453873.1_Missense_Mutation_p.S64L|KIAA1841_ENST00000482513.1_3'UTR|KIAA1841_ENST00000295031.5_Missense_Mutation_p.S64L	NM_001129993.1	NP_001123465.1	Q6NSI8	K1841_HUMAN	KIAA1841	64										breast(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	25			Epithelial(17;0.193)			AGTGGAAGCTCGCCTGTTGAC	0.358000													17	61					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10610133	10610133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr19:10610133G>A	ENST00000171111.5	-	2	1124	c.577C>T	c.(577-579)Cag>Tag	p.Q193*	KEAP1_ENST00000393623.2_Nonsense_Mutation_p.Q193*|KEAP1_ENST00000588024.1_5'UTR	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	193	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CAGCCAATCTGCTCAGCGAAG	0.597000													11	26					0	0	1	0	0
TCERG1L	256536	broad.mit.edu	37	10	133107514	133107514	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr10:133107514T>C	ENST00000368642.4	-	2	476	c.391A>G	c.(391-393)Aca>Gca	p.T131A		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	131										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		AGCTCCACTGTGGAAGAGGGG	0.527000													6	52					0	0	1	0	0
SH3D19	152503	broad.mit.edu	37	4	152070686	152070686	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr4:152070686C>G	ENST00000409598.4	-	10	2110	c.943G>C	c.(943-945)Ggt>Cgt	p.G315R	SH3D19_ENST00000304527.4_Missense_Mutation_p.G315R|SH3D19_ENST00000427414.2_Missense_Mutation_p.G279R|SH3D19_ENST00000455740.1_Missense_Mutation_p.G315R|SH3D19_ENST00000409252.2_Missense_Mutation_p.G315R|SH3D19_ENST00000424281.1_Missense_Mutation_p.G279R|SH3D19_ENST00000514152.1_Missense_Mutation_p.G315R			Q5HYK7	SH319_HUMAN	SH3 domain containing 19	315	Pro-rich.				cellular membrane organization|positive regulation of membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport	cytosol|Golgi apparatus|nucleus|plasma membrane	proline-rich region binding			autonomic_ganglia(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(1)|skin(3)|urinary_tract(1)	20	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.138)				CGCACAAAACCTCCTGTTTGA	0.413000													6	50					0	0	1	0	0
SDHAP3	728609	broad.mit.edu	37	5	1593326	1593326	+	RNA	SNP	G	G	A	rs6872202	by1000genomes	TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr5:1593326G>A	ENST00000436493.2	-	0	299																											ACCATGTACCGAGGCACAGGC	0.582000													4	51					0	0	1	0	0
RAF1	5894	broad.mit.edu	37	3	12645699	12645699	+	Missense_Mutation	SNP	G	G	A	rs80338796		TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr3:12645699G>A	ENST00000251849.4	-	7	1209	c.770C>T	c.(769-771)tCg>tTg	p.S257L	RAF1_ENST00000442415.2_Missense_Mutation_p.S257L|RAF1_ENST00000542177.1_Missense_Mutation_p.S176L|RAF1_ENST00000534997.1_Missense_Mutation_p.S42L	NM_002880.3	NP_002871.1	P04049	RAF1_HUMAN	v-raf-1 murine leukemia viral oncogene homolog 1	257			S -> L (in NS5 and LEOPARD2; shows in vitro greater kinase activity and enhanced ERK activation than wild-type).		activation of MAPKK activity|apoptosis|axon guidance|cell proliferation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of apoptosis|negative regulation of cell proliferation|negative regulation of protein complex assembly|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of peptidyl-serine phosphorylation|Ras protein signal transduction|synaptic transmission	cytosol|mitochondrial outer membrane|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity	p.S257L(3)|p.S257W(1)	ESRP1/RAF1(4)|RAF1/DAZL(2)|SRGAP3/RAF1(6)	biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	32					Sorafenib(DB00398)	TGTGGATGTCGACCTCTGCCT	0.527000			T	SRGAP3	pilocytic astrocytoma				Noonan syndrome				16	47					0	0	1	0	0
FHL2	2274	broad.mit.edu	37	2	105990143	105990143	+	Silent	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr2:105990143G>A	ENST00000409177.1	-	3	673	c.552C>T	c.(550-552)tgC>tgT	p.C184C	AC012360.6_ENST00000457290.2_RNA|FHL2_ENST00000322142.8_Silent_p.C68C|FHL2_ENST00000336660.5_Intron|FHL2_ENST00000393353.3_Silent_p.C68C|FHL2_ENST00000408995.1_Silent_p.C68C|FHL2_ENST00000409807.1_Silent_p.C68C|FHL2_ENST00000393352.3_Silent_p.C68C|FHL2_ENST00000344213.4_Silent_p.C178C|FHL2_ENST00000358129.4_Silent_p.C68C			Q14192	FHL2_HUMAN	four and a half LIM domains 2	68	LIM zinc-binding 3.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent	actin cytoskeleton|focal adhesion|nucleus	androgen receptor binding|identical protein binding|transcription coactivator activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9						TGCACTGCGAGCAGTGGAAAC	0.562000													11	38					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39624673	39624673	+	Splice_Site	SNP	A	A	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr8:39624673A>G	ENST00000265708.4	-	13	1413	c.1311_splice	c.e13+1	p.L437_splice	ADAM2_ENST00000347580.4_Splice_Site_p.L418_splice|ADAM2_ENST00000379853.2_Splice_Site_p.L311_splice|ADAM2_ENST00000521880.1_Splice_Site_p.L437_splice	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	437	Disintegrin.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		AGCTCTTACTAGACAGTTTTC	0.348000													6	102					0	0	1	0	0
PHLDA3	23612	broad.mit.edu	37	1	201437845	201437845	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr1:201437845G>A	ENST00000367311.3	-	1	467	c.70C>T	c.(70-72)Cag>Tag	p.Q24*	PHLDA3_ENST00000367309.1_Nonsense_Mutation_p.Q24*	NM_012396.3	NP_036528.1	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A, member 3	24	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding			lung(1)|prostate(1)	2						TTCCACAGCTGCAGCAGCCCG	0.721000													7	29					0	0	1	0	0
ZC3H10	84872	broad.mit.edu	37	12	56514721	56514721	+	Silent	SNP	T	T	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr12:56514721T>C	ENST00000257940.2	+	3	651	c.375T>C	c.(373-375)ctT>ctC	p.L125L	RP11-603J24.5_ENST00000549438.1_RNA|RP11-603J24.5_ENST00000550947.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	125							nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			GCCTTGGCCTTTCACCGGCTG	0.562000													17	54					0	0	1	0	0
REG1B	5968	broad.mit.edu	37	2	79313557	79313557	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr2:79313557G>A	ENST00000305089.3	-	4	337	c.257C>T	c.(256-258)tCa>tTa	p.S86L		NM_006507.3	NP_006498.1	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta	86	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(40)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	51						CTTAATCAGTGAGGCCACGAA	0.498000													12	60					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128685	45128685	+	RNA	SNP	T	T	C	rs145089594	by1000genomes	TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr17:45128685T>C	ENST00000575173.1	-	0	418																											TTCCAGGATATGGCTATACTG	0.303000													5	82					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137915	56137915	+	Silent	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr20:56137915C>T	ENST00000319441.4	+	4	734	c.570C>T	c.(568-570)gtC>gtT	p.V190V	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Silent_p.V58V	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	190					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GGGAGTTTGTCAAATGCCTCC	0.512000													13	38					0	0	1	0	0
HIST1H3I	8354	broad.mit.edu	37	6	27839923	27839923	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr6:27839923C>G	ENST00000328488.2	-	1	176	c.171G>C	c.(169-171)aaG>aaC	p.K57N		NM_003533.2	NP_003524.1	P68431	H31_HUMAN	histone cluster 1, H3i	57					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(2)|kidney(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						GCTCGGTCGACTTCTGGTAGC	0.652000													15	112					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121650424	121650424	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr7:121650424A>T	ENST00000393386.2	+	12	1735	c.1324A>T	c.(1324-1326)Att>Ttt	p.I442F	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.I442F	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	442					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGAAGGCGCTATTGTGAATCC	0.378000													11	57					0	0	1	0	0
LAPTM4B	55353	broad.mit.edu	37	8	98863681	98863681	+	Silent	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr8:98863681G>A	ENST00000445593.2	+	7	1613	c.933G>A	c.(931-933)ccG>ccA	p.P311P	LAPTM4B_ENST00000521545.2_Silent_p.P220P	NM_018407.4	NP_060877.3	Q86VI4	LAP4B_HUMAN	lysosomal protein transmembrane 4 beta	364					transport	endomembrane system|integral to membrane	protein binding	p.P311P(1)		breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	10	Breast(36;1.59e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.149)			AGGAGCCACCGCCACCTTACG	0.517000													4	50					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1482021	1482021	+	Silent	SNP	C	C	A	rs146147189		TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr7:1482021C>A	ENST00000297508.7	-	7	1693	c.1518G>T	c.(1516-1518)cgG>cgT	p.R506R	MICALL2_ENST00000405088.4_Silent_p.R294R	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	506						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GGCCAAGCACCCGGGGAGACG	0.642000													32	150					7.11191e-15	7.80016e-15	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228459861	228459861	+	Silent	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr1:228459861C>T	ENST00000570156.2	+	20	5999	c.5925C>T	c.(5923-5925)gaC>gaT	p.D1975D	RP5-1139B12.2_ENST00000602517.1_RNA|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000359599.6_Silent_p.D447D	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	956	Ig-like 19.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCCAGGCGGACGCCGGGGAGT	0.647000													14	49					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2748509	2748509	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr5:2748509G>A	ENST00000382611.6	-	3	1561	c.1313C>T	c.(1312-1314)cCg>cTg	p.P438L	IRX2_ENST00000302057.5_Missense_Mutation_p.P438L	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	438						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		GGACTCGAGCGGGTGCGCGCC	0.781000													3	3					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110385177	110385177	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr12:110385177C>T	ENST00000360185.4	-	14	1539	c.1375G>A	c.(1375-1377)Ggc>Agc	p.G459S	GIT2_ENST00000338373.5_Intron|GIT2_ENST00000354574.4_Missense_Mutation_p.G461S|GIT2_ENST00000551209.1_Missense_Mutation_p.G458S|GIT2_ENST00000355312.3_Missense_Mutation_p.G509S|GIT2_ENST00000356259.4_Intron|GIT2_ENST00000457474.2_Missense_Mutation_p.G461S|TCHP_ENST00000550780.1_Intron|GIT2_ENST00000547815.1_3'UTR|GIT2_ENST00000553118.1_Intron|GIT2_ENST00000343646.5_Missense_Mutation_p.G429S|GIT2_ENST00000361006.5_Missense_Mutation_p.G509S			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	509					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GGCCTACTGCCCCGGGCAGAC	0.537000													12	68					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9781597	9781597	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr1:9781597G>C	ENST00000536656.1	+	15	2187	c.1979G>C	c.(1978-1980)cGg>cCg	p.R660P	PIK3CD_ENST00000361110.2_Missense_Mutation_p.R660P|PIK3CD_ENST00000377346.4_Missense_Mutation_p.R636P|PIK3CD_ENST00000543390.1_Missense_Mutation_p.R303P			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	636					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		CTGCTGGACCGGGCCCTGGCC	0.617000											OREG0013082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	56					0	0	1	0	0
PCDH10	57575	broad.mit.edu	37	4	134073569	134073571	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr4:134073569_134073571delCTG	ENST00000264360.4	+	1	3100_3102	c.2274_2276delCTG	c.(2272-2277)ctc>ct	p.LC758del		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	758	Cys-rich.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		ATTGCTGCCTCTGCTGCTGCTGC	0.581													7	68	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1220615	1220616	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr19:1220615_1220616delGA	ENST00000326873.7	+	5	1806_1807	c.633_634delGA	c.(631-636)cgccfs	p.RT211fs		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	211	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)|p.T212fs*75(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		ACACCTGCCGGACCAGCCAGGG	0.723		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			6	8	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													3	4	---	---	---	---					
CYP2D7	1564	broad.mit.edu	37	22	42537119	42537120	+	RNA	INS	-	-	A	rs142656198	by1000genomes	TCGA-55-8505-01A-11D-2393-08	TCGA-55-8505-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2c050703-20d7-4a67-b723-9cbc4cc37a16	d5dd4291-df71-420d-b1be-6d3e725adc60	g.chr22:42537119_42537120insA	ENST00000435101.1	-	0	296				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						GGGCTACCACCGGGGCTGATGC	0.614													2	4	---	---	---	---