Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SIGLEC16	400709	broad.mit.edu	37	19	50474929	50474929	+	RNA	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:50474929C>A	ENST00000602139.1	+	0	1004									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						TTCAGATCCTCCAGAGAACCT	0.587000													26	41					4.59853e-10	4.86214e-10	1	1	0
ERBB3	2065	broad.mit.edu	37	12	56495462	56495462	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:56495462G>A	ENST00000267101.3	+	28	4092	c.3652G>A	c.(3652-3654)Gag>Aag	p.E1218K	RP11-603J24.9_ENST00000548861.1_Intron|ERBB3_ENST00000549832.1_Missense_Mutation_p.E338K|ERBB3_ENST00000450146.2_Missense_Mutation_p.E575K|ERBB3_ENST00000415288.2_Missense_Mutation_p.E1159K|ERBB3_ENST00000553131.1_Missense_Mutation_p.E459K	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1218					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			AAGTTCCCTTGAGGAGCTGGG	0.542000													24	49					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73489054	73489054	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:73489054C>T	ENST00000314256.7	+	16	2351	c.1957C>T	c.(1957-1959)Ctg>Ttg	p.L653L	KIAA0195_ENST00000375248.5_Silent_p.L663L|KIAA0195_ENST00000579208.1_Silent_p.L304L	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	653					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			GGAGAACCATCTGGCGCTGTA	0.627000													27	89					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125555862	125555862	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:125555862C>T	ENST00000431078.1	+	19	3543	c.3179C>T	c.(3178-3180)tCt>tTt	p.S1060F		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1060	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		AATTCTTCTTCTCAGGACTTC	0.498000													14	25					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72831616	72831616	+	Silent	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr16:72831616C>G	ENST00000268489.5	-	9	5637	c.4965G>C	c.(4963-4965)gtG>gtC	p.V1655V	ZFHX3_ENST00000397992.5_Silent_p.V741V	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	1655					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CACTGGTGCTCACAGGACTTG	0.562000													10	70					0	0	1	0	0
E2F2	1870	broad.mit.edu	37	1	23848400	23848400	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:23848400G>A	ENST00000361729.2	-	3	933	c.507C>T	c.(505-507)atC>atT	p.I169I		NM_004091.3	NP_004082.1	Q14209	E2F2_HUMAN	E2F transcription factor 2	169	Leucine-zipper.				G1 phase of mitotic cell cycle|transcription initiation from RNA polymerase II promoter	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|large_intestine(2)|lung(1)|ovary(3)|skin(2)|urinary_tract(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.52e-24)|Colorectal(126;6.25e-08)|COAD - Colon adenocarcinoma(152;3.42e-06)|GBM - Glioblastoma multiforme(114;8.98e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00102)|KIRC - Kidney renal clear cell carcinoma(1967;0.00366)|STAD - Stomach adenocarcinoma(196;0.0132)|READ - Rectum adenocarcinoma(331;0.0652)|Lung(427;0.0888)|LUSC - Lung squamous cell carcinoma(448;0.19)		TGATGTCATAGATGCGCCGCT	0.582000													10	43					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912774	77912774	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chrX:77912774G>A	ENST00000321110.1	-	2	1439	c.1144C>T	c.(1144-1146)Cta>Tta	p.L382L		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	382							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						AGATCAGATAGGTTGGTGGCT	0.493000													6	51					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1220629	1220629	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:1220629C>T	ENST00000326873.7	+	5	1820	c.647C>T	c.(646-648)tCc>tTc	p.S216F		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	216	Protein kinase.		S -> F (in sporadic cancer; somatic mutation; impairs heterotrimeric complex assembly with STRADA and CAB39).		anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.S216F(3)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCCAGGGCTCCCCGGCTTTC	0.711000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			4	7					0	0	1	0	0
C11orf82	220042	broad.mit.edu	37	11	82643010	82643010	+	Silent	SNP	A	A	G	rs140996530		TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:82643010A>G	ENST00000533655.1	+	6	842	c.630A>G	c.(628-630)tcA>tcG	p.S210S	C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000430323.2_Silent_p.S210S|C11orf82_ENST00000525388.1_3'UTR|C11orf82_ENST00000528759.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	210					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TAGATCACTCAAATAGTGATC	0.383000													57	85					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42224947	42224947	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:42224947C>G	ENST00000221992.6	+	8	1991	c.1877C>G	c.(1876-1878)tCt>tGt	p.S626C	CEA_ENST00000598976.1_Intron|CEACAM5_ENST00000398599.4_Missense_Mutation_p.S625C|CEACAM5_ENST00000405816.1_Missense_Mutation_p.S626C	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	626	Ig-like 7.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		CCGCAGTATTCTTGGCGTATC	0.522000													60	65					0	0	1	0	0
PCDHA12	56137	broad.mit.edu	37	5	140255643	140255643	+	Missense_Mutation	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:140255643C>A	ENST00000398631.2	+	1	586	c.586C>A	c.(586-588)Ctt>Att	p.L196I	PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGAATTAGTTCTTCGGAAGTT	0.363000													31	26					8.58068e-18	9.37101e-18	1	1	0
ZNF33B	7582	broad.mit.edu	37	10	43088981	43088981	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr10:43088981C>G	ENST00000359467.3	-	5	1531	c.1417G>C	c.(1417-1419)Gag>Cag	p.E473Q	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	473						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E473*(1)|p.E473Q(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						TTCCCACACTCAAGACATTCA	0.378000													43	59					0	0	1	0	0
KLHL6	89857	broad.mit.edu	37	3	183226083	183226083	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:183226083C>T	ENST00000341319.3	-	3	708	c.673G>A	c.(673-675)Gat>Aat	p.D225N		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	225	BACK.									breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			taaaggtcatcactcttcaag	0.507000													5	64					0	0	1	0	0
BEST3	144453	broad.mit.edu	37	12	70049106	70049106	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:70049106C>G	ENST00000330891.5	-	10	1814	c.1588G>C	c.(1588-1590)Gag>Cag	p.E530Q	BEST3_ENST00000553096.1_Missense_Mutation_p.E424Q|BEST3_ENST00000488961.1_Missense_Mutation_p.E317Q|BEST3_ENST00000331471.4_Intron	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	530						chloride channel complex|plasma membrane	chloride channel activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			CCTGTAAACTCAGAGCTCAAG	0.577000													55	118					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7807240	7807240	+	Silent	SNP	C	C	T	rs61744840	byFrequency	TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:7807240C>T	ENST00000380358.4	+	24	4003	c.4002C>T	c.(4000-4002)gaC>gaT	p.D1334D	CHD3_ENST00000358181.4_Silent_p.D1275D|CHD3_ENST00000330494.7_Silent_p.D1275D	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	1275					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				AGGACACTGACGTGCAGAACA	0.527000													5	62					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22853733	22853733	+	Splice_Site	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr15:22853733G>A	ENST00000283645.4	+	12	1501		c.e12-1		TUBGCP5_ENST00000453949.2_Splice_Site|TUBGCP5_ENST00000559846.1_3'UTR	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CTCTGCCTCAGGTCTCCCTCC	0.547000													7	11					0	0	1	0	0
TSC2	7249	broad.mit.edu	37	16	2120500	2120500	+	Missense_Mutation	SNP	A	A	G	rs137854371		TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr16:2120500A>G	ENST00000219476.3	+	17	2390	c.1760A>G	c.(1759-1761)tAt>tGt	p.Y587C	TSC2_ENST00000439673.2_Missense_Mutation_p.Y550C|TSC2_ENST00000382538.6_Missense_Mutation_p.Y538C|TSC2_ENST00000401874.2_Missense_Mutation_p.Y587C|TSC2_ENST00000568454.1_Missense_Mutation_p.Y598C|TSC2_ENST00000353929.4_Missense_Mutation_p.Y587C|TSC2_ENST00000350773.4_Missense_Mutation_p.Y587C	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	587					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				ACGCGTGTGTATGAGATGCTG	0.602000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				7	43					0	0	1	0	0
ALKBH6	84964	broad.mit.edu	37	19	36503936	36503936	+	Missense_Mutation	SNP	T	T	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:36503936T>C	ENST00000378875.3	-	3	199	c.194A>G	c.(193-195)tAt>tGt	p.Y65C	ALKBH6_ENST00000252984.7_Missense_Mutation_p.Y37C|ALKBH6_ENST00000495116.2_5'UTR|ALKBH6_ENST00000486389.1_Intron|ALKBH6_ENST00000485128.1_Missense_Mutation_p.Y37C|AC002116.8_ENST00000473572.2_RNA	NM_032878.3|NM_198867.1	NP_116267.3|NP_942567.1	Q3KRA9	ALKB6_HUMAN	alkB, alkylation repair homolog 6 (E. coli)	37						cytoplasm|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|skin(1)	9	all_lung(56;1.35e-06)|Lung NSC(56;2.15e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TCGAAGCAAATACTCCTCCTC	0.517000													46	72					0	0	1	0	0
ALDH3B1	221	broad.mit.edu	37	11	67789255	67789255	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:67789255G>A	ENST00000539229.1	+	8	977	c.861G>A	c.(859-861)caG>caA	p.Q287Q	ALDH3B1_ENST00000316367.6_Intron|ALDH3B1_ENST00000434449.1_3'UTR|ALDH3B1_ENST00000342456.6_Silent_p.Q251Q|ALDH3B1_ENST00000007633.8_Silent_p.Q287Q	NM_001161473.1	NP_001154945.1	P43353	AL3B1_HUMAN	aldehyde dehydrogenase 3 family, member B1	288					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase									NADH(DB00157)	TCATCAACCAGAAACAGTTCC	0.637000													17	116					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131212272	131212272	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chrX:131212272C>T	ENST00000298542.4	-	12	1948	c.1773G>A	c.(1771-1773)caG>caA	p.Q591Q	FRMD7_ENST00000464296.1_Silent_p.Q576Q|FRMD7_ENST00000370879.1_Silent_p.Q471Q	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	591					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CTGATTGGCTCTGGGACCTTT	0.433000													5	73					0	0	1	0	0
PBX2	5089	broad.mit.edu	37	6	32155509	32155509	+	Missense_Mutation	SNP	T	T	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:32155509T>A	ENST00000375050.4	-	5	1055	c.785A>T	c.(784-786)tAt>tTt	p.Y262F		NM_002586.4	NP_002577.2	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	262							transcription factor binding	p.Y262F(3)		endometrium(1)|kidney(1)|lung(9)|ovary(1)|prostate(2)	14						GGAGTAGAAATACTCATTTAG	0.517000													3	17					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30081367	30081367	+	Missense_Mutation	SNP	G	G	T	rs2071390	by1000genomes	TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr16:30081367G>T	ENST00000569798.1	+	8	1193	c.1016G>T	c.(1015-1017)aGg>aTg	p.R339M	ALDOA_ENST00000338110.5_Intron|ALDOA_ENST00000564546.1_Intron|ALDOA_ENST00000569545.1_Intron|ALDOA_ENST00000564595.2_Intron|ALDOA_ENST00000412304.2_Intron|ALDOA_ENST00000563060.2_Intron|ALDOA_ENST00000395240.3_Intron|ALDOA_ENST00000395248.1_Intron|ALDOA_ENST00000566897.1_Intron			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	0			C -> Y (in GSD12).		actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						ATAGGCAGGAGGTGGGCAGGG	0.617000													3	20					1	1	1	1	0
ZNF767	79970	broad.mit.edu	37	7	149318371	149318371	+	RNA	SNP	T	T	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr7:149318371T>C	ENST00000463567.1	-	0	465					NR_027788.1				zinc finger family member 767											central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)	5	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00434)			TCCCCCTTGCTGCCCGGGGGC	0.677000													42	93					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44177200	44177200	+	Silent	SNP	A	A	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr4:44177200A>G	ENST00000360029.3	-	2	1312	c.1029T>C	c.(1027-1029)gaT>gaC	p.D343D		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	343						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CACTTCCTTTATCAGTGACTT	0.438000										HNSCC(17;0.042)			19	60					0	0	1	0	0
GJA1	2697	broad.mit.edu	37	6	121768910	121768910	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:121768910G>A	ENST00000282561.3	+	2	1074	c.917G>A	c.(916-918)aGt>aAt	p.S306N		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	306					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	AAGCAAGCAAGTGAGCAAAAC	0.502000													23	115					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													5	87					0	0	1	0	0
CIDECP	152302	broad.mit.edu	37	3	10067794	10067794	+	RNA	SNP	A	A	G	rs35993975	by1000genomes	TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:10067794A>G	ENST00000432401.1	-	0	247																											GTGGCGGATCATGTCTACGAA	0.557000													3	28					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37584323	37584323	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr21:37584323C>T	ENST00000399151.3	+	7	917	c.832C>T	c.(832-834)Ctc>Ttc	p.L278F	DOPEY2_ENST00000492760.1_3'UTR	NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	278					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						CGTGCGCATTCTCTCAGCCGC	0.478000													16	56					0	0	1	0	0
VLDLR	7436	broad.mit.edu	37	9	2643959	2643959	+	Splice_Site	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr9:2643959C>T	ENST00000382100.2	+	7	1422	c.1066_splice	c.e7+1	p.H356_splice	VLDLR_ENST00000382099.2_Splice_Site_p.H356_splice	NM_003383.3	NP_003374.3	P98155	VLDLR_HUMAN	very low density lipoprotein receptor	356	EGF-like 1.				cholesterol metabolic process|endocytosis|lipid transport|memory|very-low-density lipoprotein particle clearance	coated pit|integral to membrane|membrane fraction|plasma membrane|very-low-density lipoprotein particle	apolipoprotein binding|calcium ion binding|low-density lipoprotein receptor activity|very-low-density lipoprotein particle receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	24				GBM - Glioblastoma multiforme(50;0.0668)|Lung(218;0.123)		GAAAGAGTGTCGTAAGTGTAC	0.448000													18	24					0	0	1	0	0
CRY1	1407	broad.mit.edu	37	12	107391777	107391777	+	Missense_Mutation	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:107391777C>A	ENST00000008527.5	-	8	2072	c.1205G>T	c.(1204-1206)tGt>tTt	p.C402F		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	402	FAD-binding.|Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						AAAGGAACTACAAGACAGCCA	0.388000													31	81					2.47511e-08	2.60043e-08	1	1	0
NUMA1	4926	broad.mit.edu	37	11	71726241	71726241	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:71726241G>A	ENST00000393695.3	-	15	2639	c.2308C>T	c.(2308-2310)Cga>Tga	p.R770*	NUMA1_ENST00000358965.6_Nonsense_Mutation_p.R770*|RP11-849H4.4_ENST00000502284.1_RNA|NUMA1_ENST00000351960.6_Intron	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	770					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						TGCTGTAATCGAGCCTCCAGC	0.627000			T	RARA	APL								27	60					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117047683	117047683	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:117047683C>G	ENST00000368564.1	+	12	1299	c.1151C>G	c.(1150-1152)cCt>cGt	p.P384R	KPNA5_ENST00000356348.1_Missense_Mutation_p.P384R			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	381	NLS binding site (minor) (By similarity).				NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		AATATTTTTCCTGTTTTGATT	0.338000													15	27					0	0	1	0	0
C17orf58	284018	broad.mit.edu	37	17	65989227	65989227	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:65989227G>A	ENST00000536693.1	-	1	441	c.36C>T	c.(34-36)ttC>ttT	p.F12F	C17orf58_ENST00000449250.2_Silent_p.F12F|C17orf58_ENST00000334461.7_Silent_p.F12F			Q2M2W7	CQ058_HUMAN	chromosome 17 open reading frame 58	12										lung(2)	2	all_cancers(12;4.57e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|LUSC - Lung squamous cell carcinoma(166;0.24)			GGACTCGGAAGAAGAAGCCGT	0.577000													24	48					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402416	33402416	+	Silent	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:33402416G>C	ENST00000373456.7	-	9	2189	c.2190C>G	c.(2188-2190)gcC>gcG	p.A730A	RNF19B_ENST00000356990.5_3'UTR|RNF19B_ENST00000235150.4_Silent_p.A729A	NM_153341.2	NP_699172.2	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	730						integral to membrane	ligase activity|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTCATACTCTGGCTTCTCCAC	0.473000													12	132					0	0	1	0	0
KRT71	112802	broad.mit.edu	37	12	52946691	52946691	+	Silent	SNP	G	G	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:52946691G>T	ENST00000267119.5	-	1	240	c.171C>A	c.(169-171)ctC>ctA	p.L57L		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	57	Gly-rich.|Head.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		TGGCCACATTGAGGCTCCGGA	0.662000													44	120					1.35964e-18	1.4947e-18	1	1	0
TP53	7157	broad.mit.edu	37	17	7577574	7577574	+	Missense_Mutation	SNP	T	T	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:7577574T>C	ENST00000420246.2	-	7	839	c.707A>G	c.(706-708)tAc>tGc	p.Y236C	TP53_ENST00000413465.2_Missense_Mutation_p.Y236C|TP53_ENST00000359597.4_Missense_Mutation_p.Y236C|TP53_ENST00000574684.1_5'UTR|TP53_ENST00000269305.4_Missense_Mutation_p.Y236C|TP53_ENST00000445888.2_Missense_Mutation_p.Y236C|TP53_ENST00000455263.2_Missense_Mutation_p.Y236C	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	236	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		Y -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|Y -> D (in sporadic cancers; somatic mutation).|Y -> F (in a sporadic cancer; somatic mutation).|Y -> H (in sporadic cancers; somatic mutation).|Y -> N (in sporadic cancers; somatic mutation).|Y -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.Y236C(61)|p.0?(8)|p.?(5)|p.Y143C(5)|p.Y236del(4)|p.Y236S(3)|p.Y236_M237delYM(1)|p.I232_Y236delIHYNY(1)|p.H233fs*6(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.Y236fs*4(1)|p.H233_C242del10(1)|p.N235_Y236delNY(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTTACACATGTAGTTGTAGTG	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			31	37					0	0	1	0	0
NRROS	375387	broad.mit.edu	37	3	196387429	196387429	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:196387429C>T	ENST00000328557.4	+	3	1118	c.915C>T	c.(913-915)ctC>ctT	p.L305L		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		AGTTCCTCCTCGTGGACGGCA	0.607000													44	65					0	0	1	0	0
GATA4	2626	broad.mit.edu	37	8	11607683	11607683	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:11607683C>T	ENST00000335135.4	+	4	1405	c.847C>T	c.(847-849)Cgc>Tgc	p.R283C	GATA4_ENST00000528712.1_Missense_Mutation_p.R77C|GATA4_ENST00000532059.1_Missense_Mutation_p.R284C	NM_002052.3	NP_002043.2	P43694	GATA4_HUMAN	GATA binding protein 4	283					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(10)	13	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CACGCTGTGGCGCCGCAATGC	0.627000													8	42					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579020	179579020	+	Splice_Site	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:179579020G>A	ENST00000589042.1	-	91	26705	c.26482_splice	c.e91+1	p.L8827_splice	TTN_ENST00000591111.1_Splice_Site_p.L8510_splice|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Splice_Site_p.L7583_splice|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8510	Ig-like 71.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTACTAACCGAGAACGGATA	0.388000													14	106					0	0	1	0	0
C1GALT1	56913	broad.mit.edu	37	7	7278152	7278152	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr7:7278152G>C	ENST00000436587.2	+	3	710	c.487G>C	c.(487-489)Gat>Cat	p.D163H	C1GALT1_ENST00000223122.2_Missense_Mutation_p.D163H|C1GALT1_ENST00000402468.3_Missense_Mutation_p.D163H	NM_020156.3	NP_064541.1	Q9NS00	C1GLT_HUMAN	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	163					angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding			breast(1)|kidney(1)|lung(3)|prostate(1)|urinary_tract(1)	7				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AGAAGATGCTGATTGGTTTTT	0.383000													19	30					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976991	119976991	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr9:119976991G>C	ENST00000313400.4	-	3	761	c.661C>G	c.(661-663)Ctg>Gtg	p.L221V	ASTN2_ENST00000373996.3_Missense_Mutation_p.L221V|ASTN2_ENST00000361209.2_Missense_Mutation_p.L221V|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GTGAACACCAGCAGCAGCAGC	0.602000													4	44					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65272803	65272803	+	RNA	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:65272803C>A	ENST00000534336.1	+	0	7571					NR_002819.2																						GGACTTGCCTCAACTCCCTCT	0.443000													5	46					1.23904e-05	1.27752e-05	1	1	0
CSMD1	64478	broad.mit.edu	37	8	3265645	3265645	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:3265645G>A	ENST00000602557.1	-	15	2405	c.1850C>T	c.(1849-1851)tCg>tTg	p.S617L	CSMD1_ENST00000539096.1_Missense_Mutation_p.S616L|CSMD1_ENST00000602723.1_Missense_Mutation_p.S617L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S616L|CSMD1_ENST00000542608.1_Missense_Mutation_p.S616L|CSMD1_ENST00000520002.1_Missense_Mutation_p.S617L|CSMD1_ENST00000400186.3_Missense_Mutation_p.S617L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	617	CUB 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCTGGCTCCGAGATAATCAA	0.403000													6	35					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123776208	123776208	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr9:123776208C>T	ENST00000223642.1	-	17	2229	c.2200G>A	c.(2200-2202)Gtc>Atc	p.V734I		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	734					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	TGGCTTGCGACGACACAACAT	0.448000													8	96					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11097633	11097633	+	RNA	SNP	A	A	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr21:11097633A>G	ENST00000470054.1	-	0	236									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ctgggcagacaatgccagaaa	0.567000													4	59					0	0	1	0	0
RRP1	8568	broad.mit.edu	37	21	45217310	45217310	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr21:45217310G>A	ENST00000497547.1	+	6	547	c.430G>A	c.(430-432)Gag>Aag	p.E144K	RRP1_ENST00000471909.1_3'UTR	NM_003683.5	NP_003674.1	P56182	RRP1_HUMAN	ribosomal RNA processing 1	144					rRNA processing	nucleolus|preribosome, small subunit precursor				central_nervous_system(1)|kidney(1)|lung(4)|stomach(2)	8				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CAGACAGATCGAGGAGCTGCT	0.577000													7	20					0	0	1	0	0
KRTAP19-2	337969	broad.mit.edu	37	21	31859601	31859601	+	Nonsense_Mutation	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr21:31859601C>A	ENST00000334055.3	-	1	154	c.67G>T	c.(67-69)Gga>Tga	p.G23*		NM_181608.1	NP_853639.1	Q3LHN2	KR192_HUMAN	keratin associated protein 19-2	23						intermediate filament				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						TATCTGCATCCTTCATAGCCG	0.547000													30	133					1.39806e-14	1.49727e-14	1	1	0
GAD1	2571	broad.mit.edu	37	2	171713609	171713609	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:171713609G>A	ENST00000358196.3	+	15	2045	c.1495G>A	c.(1495-1497)Gaa>Aaa	p.E499K		NM_000817.2	NP_000808.2	Q99259	DCE1_HUMAN	glutamate decarboxylase 1 (brain, 67kDa)	499					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion|protein-pyridoxal-5-phosphate linkage	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|plasma membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(15)|ovary(1)|urinary_tract(2)	35					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	AAACAGAGAAGAATTTGAGAT	0.423000													20	82					0	0	1	0	0
CHM	1121	broad.mit.edu	37	X	85218783	85218783	+	Missense_Mutation	SNP	T	T	C	rs140566714		TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chrX:85218783T>C	ENST00000357749.2	-	5	618	c.589A>G	c.(589-591)Agt>Ggt	p.S197G	CHM_ENST00000467744.1_Intron|CHM_ENST00000537751.1_Missense_Mutation_p.S49G	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	197					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				ACATTTTCACTCATGTCTTCT	0.368000													4	37					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178413884	178413884	+	Silent	SNP	G	G	A	rs149519053	byFrequency	TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:178413884G>A	ENST00000231188.5	-	7	1633	c.1455C>T	c.(1453-1455)ggC>ggT	p.G485G	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Silent_p.G485G	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	485					detection of visible light|visual perception	integral to plasma membrane		p.G485G(1)		NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		CCTGGTACCCGCCACTGCTGG	0.647000													14	19					0	0	1	0	0
SQSTM1	8878	broad.mit.edu	37	5	179263610	179263610	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:179263610C>T	ENST00000510187.1	+	7	1106	c.1090C>T	c.(1090-1092)Ctt>Ttt	p.L364F	SQSTM1_ENST00000389805.4_3'UTR|SQSTM1_ENST00000376929.3_3'UTR|C5orf45_ENST00000403396.2_3'UTR|SQSTM1_ENST00000360718.5_3'UTR|SQSTM1_ENST00000402874.3_3'UTR			Q13501	SQSTM_HUMAN	sequestosome 1	0	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTGCCCACCTCTTCTGCGTGC	0.542000													39	64					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164709969	164709969	+	Missense_Mutation	SNP	T	T	C	rs113739230		TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:164709969T>C	ENST00000264382.3	-	43	5041	c.4979A>G	c.(4978-4980)cAt>cGt	p.H1660R		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1660	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACTTACTGTATGGTAGTCAAA	0.358000										HNSCC(35;0.089)			41	73					0	0	1	0	0
RIC8B	55188	broad.mit.edu	37	12	107236557	107236557	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:107236557C>T	ENST00000392837.4	+	5	1178	c.1027C>T	c.(1027-1029)Cat>Tat	p.H343Y	RIC8B_ENST00000392839.2_Missense_Mutation_p.H343Y|RIC8B_ENST00000549643.1_Intron|RIC8B_ENST00000355478.2_Missense_Mutation_p.H303Y			Q9NVN3	RIC8B_HUMAN	RIC8 guanine nucleotide exchange factor B	343					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	19						GGAGGCCATTCATGTTTTACT	0.368000													14	40					0	0	1	0	0
ARHGAP5	394	broad.mit.edu	37	14	32563294	32563294	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr14:32563294G>A	ENST00000345122.3	+	2	3734	c.3419G>A	c.(3418-3420)aGa>aAa	p.R1140K	ARHGAP5_ENST00000432921.1_Missense_Mutation_p.R1140K|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.R1140K|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.R1140K|ARHGAP5_ENST00000433497.1_Intron	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	1140					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TTTTCTGATAGAACCTCAAAA	0.333000													17	29					0	0	1	0	0
IFT122	55764	broad.mit.edu	37	3	129168748	129168748	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:129168748C>G	ENST00000296266.3	+	2	268	c.76C>G	c.(76-78)Caa>Gaa	p.Q26E	IFT122_ENST00000349441.2_Missense_Mutation_p.Q26E|IFT122_ENST00000348417.2_Missense_Mutation_p.Q26E|IFT122_ENST00000347300.2_Missense_Mutation_p.Q26E|IFT122_ENST00000431818.2_5'UTR|IFT122_ENST00000440957.2_5'UTR|IFT122_ENST00000504021.1_Missense_Mutation_p.Q26E|IFT122_ENST00000507564.1_Missense_Mutation_p.Q26E	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	26					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						TGATGGAACTCAACTGATTTT	0.408000													5	72					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219870935	219870935	+	Missense_Mutation	SNP	G	G	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:219870935G>T	ENST00000341552.5	-	31	4813	c.4730C>A	c.(4729-4731)cCc>cAc	p.P1577H	CCDC108_ENST00000453220.1_Missense_Mutation_p.P1577H|CCDC108_ENST00000441968.1_Missense_Mutation_p.P1577H|AC097468.4_ENST00000441450.1_RNA	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1577						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTTCTTGATGGGAGGCAGTGT	0.612000													5	76					0.014758	0.0148474	1	1	0
RNF43	54894	broad.mit.edu	37	17	56438227	56438227	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:56438227G>C	ENST00000584437.1	-	6	2721	c.766C>G	c.(766-768)Cgg>Ggg	p.R256G	RNF43_ENST00000500597.2_Missense_Mutation_p.R215G|RNF43_ENST00000583753.1_Missense_Mutation_p.R215G|RNF43_ENST00000577625.1_Missense_Mutation_p.R129G|RNF43_ENST00000407977.2_Missense_Mutation_p.R256G|RNF43_ENST00000577716.1_Missense_Mutation_p.R256G|RNF43_ENST00000581868.1_Missense_Mutation_p.R129G|BZRAP1-AS1_ENST00000583841.1_RNA			Q68DV7	RNF43_HUMAN	ring finger protein 43	256						endoplasmic reticulum membrane|integral to membrane|nuclear envelope	ligase activity|protein binding|zinc ion binding			NS(1)|biliary_tract(5)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(14)|lung(9)|ovary(2)|pancreas(10)|prostate(1)|skin(4)	60	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CACTCACCCCGGGCCTGCCTG	0.637000													11	24					0	0	1	0	0
FFAR1	2864	broad.mit.edu	37	19	35842853	35842853	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:35842853C>T	ENST00000246553.2	+	1	409	c.399C>T	c.(397-399)ctC>ctT	p.L133L		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	133					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	TCTGGGCCCTCGTCCTGTGTC	0.652000													10	75					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446851	85446851	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:85446851C>G	ENST00000369663.5	-	8	1713	c.1376G>C	c.(1375-1377)gGc>gCc	p.G459A	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	459					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GCTGCTCACGCCCACATAGGA	0.577000													36	86					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124982337	124982337	+	Splice_Site	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:124982337C>A	ENST00000522917.1	+	6	653	c.447_splice	c.e6+1	p.S149_splice	FER1L6_ENST00000399018.1_Splice_Site_p.S149_splice	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	149	C2 1.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCAAAATCTCCGTAAGTATAG	0.443000													37	42					4.92203e-23	5.44704e-23	1	1	0
TENM3	55714	broad.mit.edu	37	4	183676138	183676138	+	Missense_Mutation	SNP	G	G	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr4:183676138G>T	ENST00000511685.1	+	22	4741	c.4618G>T	c.(4618-4620)Gat>Tat	p.D1540Y	TENM3_ENST00000406950.2_Missense_Mutation_p.D1540Y|TENM3_ENST00000502950.1_3'UTR					teneurin transmembrane protein 3																		AGTCACTGGTGATTACCTTTA	0.393000													13	31					0.00136819	0.00138488	1	1	0
HIST1H3C	8352	broad.mit.edu	37	6	26045818	26045818	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:26045818G>A	ENST00000540144.1	+	1	180	c.180G>A	c.(178-180)gaG>gaA	p.E60E		NM_003531.2	NP_003522.1	P68431	H31_HUMAN	histone cluster 1, H3c	60					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|skin(1)	8						AGTCCACCGAGCTGCTGATCC	0.637000													27	69					0	0	1	0	0
LTBP2	4053	broad.mit.edu	37	14	74976824	74976824	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr14:74976824C>T	ENST00000261978.4	-	20	3507	c.3121G>A	c.(3121-3123)Gag>Aag	p.E1041K	LTBP2_ENST00000556690.1_Missense_Mutation_p.E1041K	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1041	Cys-rich.|EGF-like 8; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GAGGTGACCTCATAGCCCTGC	0.582000													16	18					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185181348	185181348	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:185181348G>C	ENST00000265026.3	+	8	1623	c.1289G>C	c.(1288-1290)aGa>aCa	p.R430T	MAP3K13_ENST00000446828.1_Missense_Mutation_p.R223T|MAP3K13_ENST00000535426.1_Missense_Mutation_p.R286T|MAP3K13_ENST00000424227.1_Missense_Mutation_p.R430T|MAP3K13_ENST00000443863.1_Missense_Mutation_p.R286T	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	430					activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GCTGAATGGAGAGAAGAAGTG	0.383000													11	60					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89198748	89198748	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:89198748C>T	ENST00000286614.6	-	3	642	c.361G>A	c.(361-363)Gca>Aca	p.A121T	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	121					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						CCTGTCAATGCATATCGCTTT	0.398000													97	114					0	0	1	0	0
RUFY3	22902	broad.mit.edu	37	4	71660566	71660566	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr4:71660566C>T	ENST00000381006.3	+	14	2091	c.1512C>T	c.(1510-1512)gaC>gaT	p.D504D	RUFY3_ENST00000502653.1_Silent_p.D451D	NM_001037442.2	NP_001032519.1	Q7L099	RUFY3_HUMAN	RUN and FYVE domain containing 3	339					negative regulation of axonogenesis	filopodium|growth cone				endometrium(1)|kidney(3)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)	16		all_hematologic(202;0.248)	Lung(101;0.235)			TACAAAACGACAGGAGCATCC	0.363000													20	76					0	0	1	0	0
ENC1	8507	broad.mit.edu	37	5	73931477	73931477	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:73931477C>T	ENST00000302351.4	-	2	1964	c.834G>A	c.(832-834)caG>caA	p.Q278Q	ENC1_ENST00000510316.1_Silent_p.Q205Q|ENC1_ENST00000537006.1_Silent_p.Q278Q	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	278					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		CACCGTCATTCTGCAGGATTT	0.498000													26	51					0	0	1	0	0
STAT5B	6777	broad.mit.edu	37	17	40384039	40384039	+	Missense_Mutation	SNP	T	T	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:40384039T>G	ENST00000293328.3	-	2	275	c.107A>C	c.(106-108)cAg>cCg	p.Q36P		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	36					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	TTCAATCCACTGGGATAAATA	0.428000													29	65					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6635621	6635621	+	Silent	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:6635621C>A	ENST00000315579.5	+	21	3373	c.2574C>A	c.(2572-2574)gtC>gtA	p.V858V	NCAPD2_ENST00000545962.1_Silent_p.V813V|NCAPD2_ENST00000542492.1_3'UTR	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	858					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CAGGCTTTGTCCACCCAGACC	0.547000													25	61					5.45024e-15	5.87493e-15	1	1	0
FBN3	84467	broad.mit.edu	37	19	8161800	8161800	+	Missense_Mutation	SNP	C	C	A	rs143230386	by1000genomes	TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:8161800C>A	ENST00000600128.1	-	43	5792	c.5378G>T	c.(5377-5379)cGa>cTa	p.R1793L	FBN3_ENST00000270509.2_Missense_Mutation_p.R1793L|FBN3_ENST00000601739.1_Missense_Mutation_p.R1793L			Q75N90	FBN3_HUMAN	fibrillin 3	1793	EGF-like 27; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						TTTGTACCCTCGGGTGCACTT	0.607000													28	38					4.59853e-10	4.86214e-10	1	1	0
CIDECP	152302	broad.mit.edu	37	3	10067797	10067797	+	RNA	SNP	T	T	C	rs33917318	by1000genomes	TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:10067797T>C	ENST00000432401.1	-	0	244																											GCGGATCATGTCTACGAAGAG	0.562000													3	29					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176004449	176004449	+	Missense_Mutation	SNP	C	C	T	rs3762960		TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:176004449C>T	ENST00000510636.1	+	13	1518	c.1244C>T	c.(1243-1245)gCc>gTc	p.A415V	CDHR2_ENST00000261944.5_Missense_Mutation_p.A415V|CDHR2_ENST00000506348.1_Missense_Mutation_p.A415V	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	415	Cadherin 4.		A -> G (in dbSNP:rs3762960).		homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GATGCAGAAGCCTTCAGCGTC	0.657000													4	5					0	0	1	0	0
KCTD3	51133	broad.mit.edu	37	1	215793728	215793728	+	Missense_Mutation	SNP	A	A	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:215793728A>G	ENST00000259154.4	+	18	2510	c.2216A>G	c.(2215-2217)aAg>aGg	p.K739R	KCTD3_ENST00000495537.1_3'UTR	NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	739						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TCAGAATCCAAGAAAAGGTCA	0.353000													7	84					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56557512	56557512	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:56557512G>A	ENST00000323777.3	-	2	776	c.667C>T	c.(667-669)Cgg>Tgg	p.R223W		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	223						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					ACTGGGGTCCGATCTAAACCT	0.468000													35	105					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16870183	16870183	+	Silent	SNP	A	A	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:16870183A>G	ENST00000524140.2	+	7	2335	c.1917A>G	c.(1915-1917)ggA>ggG	p.G639G	NWD1_ENST00000552788.1_Silent_p.G639G|NWD1_ENST00000549814.1_Silent_p.G639G|NWD1_ENST00000523826.1_Silent_p.G433G|NWD1_ENST00000379808.3_Silent_p.G639G|NWD1_ENST00000339803.6_Silent_p.G504G	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	639	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GGGATCTGGGATACTACTTGG	0.662000													15	14					0	0	1	0	0
EFCAB5	374786	broad.mit.edu	37	17	28296356	28296356	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:28296356G>C	ENST00000394835.3	+	4	930	c.738G>C	c.(736-738)aaG>aaC	p.K246N	EFCAB5_ENST00000536908.2_Missense_Mutation_p.K190N|EFCAB5_ENST00000534836.2_Intron|EFCAB5_ENST00000378738.3_Missense_Mutation_p.K246N|EFCAB5_ENST00000541045.1_Intron|EFCAB5_ENST00000394832.2_Missense_Mutation_p.K246N|EFCAB5_ENST00000320856.5_Missense_Mutation_p.K246N	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	246							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						AAGACCTGAAGATATATGTTC	0.338000													7	21					0	0	1	0	0
MCTS1	28985	broad.mit.edu	37	X	119739990	119739990	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chrX:119739990G>A	ENST00000371315.3	+	3	757	c.224G>A	c.(223-225)aGa>aAa	p.R75K	MCTS1_ENST00000371317.5_Missense_Mutation_p.R74K|MCTS1_ENST00000487133.1_3'UTR	NM_001137554.1	NP_001131026.1	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1	74					cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|stomach(1)|urinary_tract(1)	10						TTTAGACAAAGAGAAGGGCCT	0.279000													5	6					0	0	1	0	0
LGALS3BP	3959	broad.mit.edu	37	17	76968021	76968021	+	Silent	SNP	T	T	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:76968021T>C	ENST00000262776.3	-	6	1703	c.1395A>G	c.(1393-1395)caA>caG	p.Q465Q	LGALS3BP_ENST00000591778.1_3'UTR	NM_005567.3	NP_005558.1	Q08380	LG3BP_HUMAN	lectin, galactoside-binding, soluble, 3 binding protein	465					cell adhesion|cellular defense response	extracellular space|membrane|proteinaceous extracellular matrix	protein binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(5)|endometrium(3)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(99;0.0677)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			AGCTGGGGTGTTGTGGAGTCT	0.557000											OREG0024787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	33					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35921144	35921144	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:35921144C>T	ENST00000397367.2	-	2	205	c.79G>A	c.(79-81)Gaa>Aaa	p.E27K	CAPSL_ENST00000397366.1_Missense_Mutation_p.E27K|CAPSL_ENST00000514524.1_Missense_Mutation_p.E27K	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	27						cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			CGGAGTCTTTCAATGGGGTCG	0.602000													24	94					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3673252	3673252	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr20:3673252G>A	ENST00000344754.4	-	15	3945	c.3946C>T	c.(3946-3948)Cgg>Tgg	p.R1316W	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.R1316W	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1316	Ig-like C2-type 13.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCATGAGCCCGCGTGGCCACC	0.652000													6	22					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178096180	178096180	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:178096180G>A	ENST00000397062.3	-	5	1705	c.1151C>T	c.(1150-1152)gCc>gTc	p.A384V	NFE2L2_ENST00000464747.1_Missense_Mutation_p.A368V|NFE2L2_ENST00000446151.2_Missense_Mutation_p.A361V|NFE2L2_ENST00000397063.4_Missense_Mutation_p.A368V	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	384					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			ACTTCCAGGGGCACTATCTAG	0.498000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			60	88					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98763931	98763931	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr10:98763931G>A	ENST00000266058.4	-	34	4004	c.3759C>T	c.(3757-3759)gcC>gcT	p.A1253A	SLIT1_ENST00000371070.4_Silent_p.A1253A|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1253	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCTGGTCAAAGGCAACCAGCT	0.557000													57	137					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155155736	155155736	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr4:155155736G>A	ENST00000357232.3	-	25	8702	c.8703C>T	c.(8701-8703)atC>atT	p.I2901I		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	2901					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ATGTACCACTGATGTGTGTTC	0.433000													21	52					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160585554	160585554	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:160585554G>C	ENST00000259050.3	+	2	143	c.21G>C	c.(19-21)agG>agC	p.R7S	MARCH7_ENST00000539065.1_Missense_Mutation_p.R7S|MARCH7_ENST00000409175.1_Missense_Mutation_p.R7S|MARCH7_ENST00000473749.1_3'UTR	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	7							ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						AACCTTCAAGGATTCCAAGAA	0.348000													4	24					0	0	1	0	0
DNM2	1785	broad.mit.edu	37	19	10893794	10893794	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:10893794C>G	ENST00000314646.5	+	6	1011	c.847C>G	c.(847-849)Cag>Gag	p.Q283E	DNM2_ENST00000359692.6_Missense_Mutation_p.Q283E|DNM2_ENST00000408974.4_Missense_Mutation_p.Q283E|DNM2_ENST00000389253.4_Missense_Mutation_p.Q283E|DNM2_ENST00000585892.1_Missense_Mutation_p.Q283E|DNM2_ENST00000355667.6_Missense_Mutation_p.Q283E			P50570	DYN2_HUMAN	dynamin 2	283					G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	42			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GACGCTGAATCAGGTACTGCA	0.582000			"""F, N, Splice, Mis, O"""		ETP ALL								16	26					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24535346	24535346	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:24535346C>T	ENST00000264463.4	-	5	1196	c.689G>A	c.(688-690)aGa>aAa	p.R230K		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	230	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GTATTGCTCTCTGTTTTCTCT	0.423000										HNSCC(23;0.051)			20	128					0	0	1	0	0
IFT52	51098	broad.mit.edu	37	20	42232421	42232421	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr20:42232421C>G	ENST00000373030.3	+	4	359	c.229C>G	c.(229-231)Ctt>Gtt	p.L77V	IFT52_ENST00000373039.4_Missense_Mutation_p.L77V	NM_016004.2	NP_057088.2	Q9Y366	IFT52_HUMAN	intraflagellar transport 52 homolog (Chlamydomonas)	77						intraflagellar transport particle B|microtubule-based flagellum	protein C-terminus binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GAAGAAATATCTTGACACTGG	0.348000													20	24					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237057670	237057670	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:237057670C>G	ENST00000366577.5	+	30	3612	c.3218C>G	c.(3217-3219)tCt>tGt	p.S1073C	MTR_ENST00000470570.1_3'UTR|MTR_ENST00000535889.1_Missense_Mutation_p.S1022C	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	1073	AdoMet activation.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GAGAAGGACTCTGCCAGCACG	0.572000													8	52					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	106898816	106898816	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr7:106898816C>G	ENST00000393603.2	-	15	1952	c.1681G>C	c.(1681-1683)Gga>Cga	p.G561R	COG5_ENST00000347053.3_Missense_Mutation_p.G561R|COG5_ENST00000297135.3_Missense_Mutation_p.G561R	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	561					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding	p.G561R(1)		breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						CTTGCATCTCCTTGTGTGGAG	0.408000													24	43					0	0	1	0	0
PLA2G12B	84647	broad.mit.edu	37	10	74701039	74701039	+	Missense_Mutation	SNP	A	A	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr10:74701039A>C	ENST00000373032.3	-	3	446	c.354T>G	c.(352-354)tgT>tgG	p.C118W		NM_032562.2	NP_115951.2	Q9BX93	PG12B_HUMAN	phospholipase A2, group XIIB	118					lipid catabolic process	extracellular region	calcium ion binding|phospholipase A2 activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|skin(2)	9	Prostate(51;0.0198)					AAGTGTCATAACAGACATCCA	0.493000													55	106					0	0	1	0	0
MAP3K13	9175	broad.mit.edu	37	3	185181373	185181373	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:185181373G>A	ENST00000265026.3	+	8	1648	c.1314G>A	c.(1312-1314)gaG>gaA	p.E438E	MAP3K13_ENST00000446828.1_Silent_p.E231E|MAP3K13_ENST00000535426.1_Silent_p.E294E|MAP3K13_ENST00000424227.1_Silent_p.E438E|MAP3K13_ENST00000443863.1_Silent_p.E294E	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	438	Leucine-zipper 1.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			AACATTTTGAGAAGATCAAAA	0.413000													14	55					0	0	1	0	0
NLRC5	84166	broad.mit.edu	37	16	57063721	57063721	+	Silent	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr16:57063721G>C	ENST00000436936.1	+	9	2505	c.2280G>C	c.(2278-2280)ctG>ctC	p.L760L	NLRC5_ENST00000308149.7_Silent_p.L760L|NLRC5_ENST00000262510.6_Silent_p.L760L|NLRC5_ENST00000539144.1_Silent_p.L760L			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	760					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				AGGTGGTGCTGAACATTGTGG	0.572000													7	46					0	0	1	0	0
NAGPA	51172	broad.mit.edu	37	16	5083366	5083366	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr16:5083366C>T	ENST00000312251.3	-	2	469	c.450G>A	c.(448-450)ggG>ggA	p.G150G	NAGPA_ENST00000381955.3_Silent_p.G150G|RP11-165E7.1_ENST00000588778.1_RNA|NAGPA_ENST00000564922.1_5'UTR	NM_016256.3	NP_057340.2	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	150					carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity			endometrium(4)|large_intestine(4)|lung(3)|urinary_tract(1)	12					N-Acetyl-D-glucosamine(DB00141)	TCACCACGTTCCCCAGGCACT	0.726000													3	9					0	0	1	0	0
CCDC7	221016	broad.mit.edu	37	10	32856604	32856604	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr10:32856604G>C	ENST00000362006.5	+	16	1747	c.1204G>C	c.(1204-1206)Gaa>Caa	p.E402Q	C10orf68_ENST00000572165.1_3'UTR|CCDC7_ENST00000277657.6_Missense_Mutation_p.E402Q	NM_145023.4	NP_659460.3	Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7	402										NS(1)|breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)	14		Breast(68;0.000207)|Prostate(175;0.0107)				ACAGGAAGCTGAAAAAGCTAA	0.333000													6	21					0	0	1	0	0
HCAR3	8843	broad.mit.edu	37	12	123200545	123200545	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:123200545C>G	ENST00000528880.2	-	1	894	c.740G>C	c.(739-741)aGc>aCc	p.S247T	HCAR1_ENST00000356987.2_Intron	NM_006018.2	NP_006009.2	P49019	HCAR3_HUMAN	hydroxycarboxylic acid receptor 3	247						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	9					Mepenzolate(DB04843)|Niacin(DB00627)	CACAACCACGCTGGGAAGGAA	0.552000													7	19					0	0	1	0	0
ABLIM2	84448	broad.mit.edu	37	4	8089921	8089921	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr4:8089921G>A	ENST00000296372.8	-	4	571	c.429C>T	c.(427-429)agC>agT	p.S143S	ABLIM2_ENST00000361581.5_Silent_p.S143S|ABLIM2_ENST00000447017.2_Silent_p.S143S|ABLIM2_ENST00000361737.5_Silent_p.S143S|ABLIM2_ENST00000318888.4_5'UTR|ABLIM2_ENST00000407564.3_Silent_p.S143S|ABLIM2_ENST00000545242.1_Silent_p.S143S|ABLIM2_ENST00000546334.1_Silent_p.S143S|ABLIM2_ENST00000428004.2_Silent_p.S143S|ABLIM2_ENST00000505872.1_Silent_p.S143S|ABLIM2_ENST00000341937.5_Silent_p.S143S			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	143					axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						ACAGGTGCGCGCTGCTGCCCA	0.632000													16	17					0	0	1	0	0
KIAA0195	9772	broad.mit.edu	37	17	73487524	73487524	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:73487524C>T	ENST00000314256.7	+	13	1768	c.1374C>T	c.(1372-1374)ttC>ttT	p.F458F	KIAA0195_ENST00000375248.5_Silent_p.F468F|KIAA0195_ENST00000579208.1_Silent_p.F109F	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	458					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCCGCTCCTTCTGCCATCCCG	0.632000													36	68					0	0	1	0	0
PDGFRL	5157	broad.mit.edu	37	8	17486207	17486207	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:17486207G>C	ENST00000541323.1	+	5	1162	c.717G>C	c.(715-717)gaG>gaC	p.E239D	PDGFRL_ENST00000398074.3_Missense_Mutation_p.E239D|PDGFRL_ENST00000251630.6_Missense_Mutation_p.E239D	NM_006207.2	NP_006198.1	Q15198	PGFRL_HUMAN	platelet-derived growth factor receptor-like	239						extracellular region	platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)	9				Colorectal(111;0.0752)		CTCATTCCGAGCACCAGGGTG	0.577000													8	65					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11786923	11786923	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:11786923G>A	ENST00000262442.3	+	56	10895	c.10827G>A	c.(10825-10827)caG>caA	p.Q3609Q	DNAH9_ENST00000396001.2_5'UTR|DNAH9_ENST00000454412.2_Silent_p.Q3609Q	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3609	AAA 5 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CAAAGCAGCAGAATGGATTCA	0.502000													45	43					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60193861	60193861	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr14:60193861C>T	ENST00000267484.5	-	3	1876	c.1541G>A	c.(1540-1542)cGg>cAg	p.R514Q		NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	514					neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GGCCAGGCCCCGCCGGCTTGG	0.726000													4	11					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2413747	2413747	+	Missense_Mutation	SNP	T	T	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr19:2413747T>G	ENST00000332578.3	+	9	1202	c.1202T>G	c.(1201-1203)tTt>tGt	p.F401C		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	401	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCCGGTTCTTTCTGGCTGGC	0.642000													14	49					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25220650	25220650	+	Nonsense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:25220650C>T	ENST00000276440.7	+	29	3081	c.3037C>T	c.(3037-3039)Caa>Taa	p.Q1013*		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1013						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		GAATATGACTCAAAACAGGTG	0.448000													19	59					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196884094	196884094	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:196884094G>C	ENST00000367416.2	+	9	1500	c.1363G>C	c.(1363-1365)Gaa>Caa	p.E455Q	CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000367418.1_Missense_Mutation_p.E209Q|CFHR4_ENST00000251424.4_Missense_Mutation_p.E209Q	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						AGATTCTTCAGAAAAGTGTGG	0.358000													6	118					0	0	1	0	0
IGFBP4	3487	broad.mit.edu	37	17	38610236	38610236	+	Silent	SNP	A	A	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:38610236A>G	ENST00000269593.4	+	3	839	c.564A>G	c.(562-564)tcA>tcG	p.S188S	IGFBP4_ENST00000542955.1_Silent_p.S88S	NM_001552.2	NP_001543.2	P22692	IBP4_HUMAN	insulin-like growth factor binding protein 4	188	Thyroglobulin type-1.				DNA metabolic process|signal transduction|skeletal system development					NS(1)|endometrium(1)|kidney(1)|large_intestine(2)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TGGCCGCTTCACAGAGCCGCA	0.647000													37	93					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032181	26032181	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:26032181C>T	ENST00000244661.2	-	1	107	c.108G>A	c.(106-108)gtG>gtA	p.V36V		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	36					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						GAGGCTTTTTCACGCCGCCGG	0.627000													55	125					0	0	1	0	0
PIAS3	10401	broad.mit.edu	37	1	145580237	145580237	+	Missense_Mutation	SNP	G	G	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:145580237G>T	ENST00000393045.2	+	6	809	c.719G>T	c.(718-720)cGc>cTc	p.R240L	PIAS3_ENST00000369298.1_Missense_Mutation_p.R205L|PIAS3_ENST00000369299.3_Missense_Mutation_p.R231L	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	240	PINIT.				positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AGGCCCAGCCGCCCCATCAAC	0.587000													25	149					1.55469e-16	1.68679e-16	1	1	0
GRHL2	79977	broad.mit.edu	37	8	102570864	102570864	+	Missense_Mutation	SNP	A	A	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr8:102570864A>T	ENST00000251808.3	+	4	840	c.502A>T	c.(502-504)Atg>Ttg	p.M168L	GRHL2_ENST00000395927.1_Missense_Mutation_p.M152L	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	168						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ACCAGTTTTCATGGCCCCACC	0.562000													29	66					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115336635	115336635	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr9:115336635C>G	ENST00000337530.6	+	2	571	c.275C>G	c.(274-276)tCt>tGt	p.S92C	KIAA1958_ENST00000536272.1_Missense_Mutation_p.S92C|KIAA1958_ENST00000374244.3_Missense_Mutation_p.S92C	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	92										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						GGGGTGCCCTCTGAGACACAG	0.498000													10	78					0	0	1	0	0
MYO1B	4430	broad.mit.edu	37	2	192279318	192279318	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:192279318G>C	ENST00000392318.3	+	29	3329	c.3082G>C	c.(3082-3084)Gag>Cag	p.E1028Q	MYO1B_ENST00000339514.4_Missense_Mutation_p.E970Q|MYO1B_ENST00000304164.4_Missense_Mutation_p.E1028Q|MYO1B_ENST00000439065.2_Missense_Mutation_p.E273Q|MYO1B_ENST00000392316.1_Missense_Mutation_p.E999Q	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	1028						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			AATCAAGTCAGAGGTTCCATT	0.383000													5	44					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89499342	89499342	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:89499342G>A	ENST00000336596.2	+	15	2737	c.2512G>A	c.(2512-2514)Gat>Aat	p.D838N	EPHA3_ENST00000494014.1_Missense_Mutation_p.D838N	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	838	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TAAAGCTGTAGATGAGGGCTA	0.493000										TSP Lung(6;0.00050)			20	20					0	0	1	0	0
ANO1	55107	broad.mit.edu	37	11	70007391	70007391	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:70007391C>T	ENST00000355303.5	+	17	2008	c.1703C>T	c.(1702-1704)gCa>gTa	p.A568V	ANO1_ENST00000316296.5_Missense_Mutation_p.A510V|ANO1_ENST00000530676.1_Missense_Mutation_p.A422V|ANO1_ENST00000398543.2_Missense_Mutation_p.A422V|ANO1_ENST00000531349.1_Missense_Mutation_p.A277V|ANO1_ENST00000538023.1_Missense_Mutation_p.A568V	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	568					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						ACAGCCACCGCAGTCATCATC	0.587000													6	63					0	0	1	0	0
DPPA3	359787	broad.mit.edu	37	12	7864204	7864204	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:7864204G>A	ENST00000345088.2	+	1	155	c.38G>A	c.(37-39)gGg>gAg	p.G13E		NM_199286.2	NP_954980.1	Q6W0C5	DPPA3_HUMAN	developmental pluripotency associated 3	13						cytoplasm|nucleus				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(2)	8				Kidney(36;0.0887)		TACATCCCAGGGTCTCCACAA	0.483000													12	31					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63198131	63198131	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr17:63198131G>A	ENST00000449996.3	+	14	1060	c.988G>A	c.(988-990)Gaa>Aaa	p.E330K	RGS9_ENST00000262406.9_Missense_Mutation_p.E333K|RGS9_ENST00000443584.3_Missense_Mutation_p.E330K	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	333	RGS.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						GGGATTCTGGGAAGCCTGCGA	0.483000													18	52					0	0	1	0	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043672	26043672	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:26043672C>G	ENST00000357905.2	-	1	213	c.214G>C	c.(214-216)Gag>Cag	p.E72Q		NM_021062.2	NP_066406.1	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	72					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						GCGATGCGCTCGAAGATGTCG	0.572000													63	127					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6637215	6637215	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:6637215C>T	ENST00000315579.5	+	24	3900	c.3101C>T	c.(3100-3102)tCt>tTt	p.S1034F	NCAPD2_ENST00000545962.1_Missense_Mutation_p.S989F|NCAPD2_ENST00000542492.1_3'UTR	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1034					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						CCAGACCTCTCTGCAGCTGCT	0.522000													46	117					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58126243	58126243	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:58126243G>C	ENST00000357377.3	-	1	299	c.300C>G	c.(298-300)ttC>ttG	p.F100L		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	100					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CTGCACAAAAGAACATCTGAG	0.478000													29	31					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101528870	101528870	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr15:101528870G>C	ENST00000284395.5	+	6	856	c.456G>C	c.(454-456)tgG>tgC	p.W152C	LRRK1_ENST00000532029.2_Missense_Mutation_p.W155C|LRRK1_ENST00000388948.3_Missense_Mutation_p.W155C			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	155					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TTCTGAACTGGATGCTGGCCT	0.612000													28	65					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133805952	133805952	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:133805952G>A	ENST00000321016.8	-	6	1047	c.817C>T	c.(817-819)Cag>Tag	p.Q273*	IGSF9B_ENST00000533871.2_Nonsense_Mutation_p.Q273*			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	273	Ig-like 3.					integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		GCTCACTTCTGAAAGTAGACG	0.617000													4	12					0	0	1	0	0
OPALIN	93377	broad.mit.edu	37	10	98118916	98118916	+	Translation_Start_Site	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr10:98118916C>A	ENST00000419479.1	-	0	176				OPALIN_ENST00000371172.3_De_novo_Start_InFrame|OPALIN_ENST00000393871.1_De_novo_Start_InFrame	NM_001040103.1	NP_001035192.1	Q96PE5	OPALI_HUMAN	oligodendrocytic myelin paranodal and inner loop protein							Golgi apparatus|integral to membrane|plasma membrane				breast(1)|large_intestine(1)|lung(5)|prostate(2)	9						CCCTCTTTGCCTTGATTTTCT	0.562000													4	5					0.000602214	0.000613298	1	1	0
GPR65	8477	broad.mit.edu	37	14	88478137	88478137	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr14:88478137C>G	ENST00000267549.3	+	2	1504	c.946C>G	c.(946-948)Caa>Gaa	p.Q316E	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	316					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TAATACATCACAAAGACAAAG	0.363000													11	16					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810602	123810602	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:123810602C>T	ENST00000307033.2	+	1	353	c.279C>T	c.(277-279)tcC>tcT	p.S93S		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTACCATTTCCTTTGGTGGAT	0.468000													47	75					0	0	1	0	0
DROSHA	29102	broad.mit.edu	37	5	31448657	31448657	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr5:31448657G>A	ENST00000511367.2	-	22	3123	c.2879C>T	c.(2878-2880)tCg>tTg	p.S960L	DROSHA_ENST00000344624.3_Missense_Mutation_p.S960L|DROSHA_ENST00000442743.1_Missense_Mutation_p.S923L|DROSHA_ENST00000513349.1_Missense_Mutation_p.S923L	NM_013235.4	NP_037367.3	Q9NRR4	RNC_HUMAN	drosha, ribonuclease type III	960	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|RNase III 1.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(19)|lung(33)|ovary(2)|skin(1)	66						ACTTTACCTCGAGGGAGTTGG	0.313000													8	33					0	0	1	0	0
C2orf40	84417	broad.mit.edu	37	2	106690449	106690449	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr2:106690449G>A	ENST00000409944.1	+	4	358	c.127G>A	c.(127-129)Gag>Aag	p.E43K	C2orf40_ENST00000238044.3_Missense_Mutation_p.E79K|C2orf40_ENST00000489174.1_3'UTR			Q9H1Z8	AUGN_HUMAN	chromosome 2 open reading frame 40	79						extracellular region|transport vesicle				lung(7)|urinary_tract(1)	8						GACTCGGCCCGAGGTGCAGCA	0.577000													6	109					0	0	1	0	0
SLC26A3	1811	broad.mit.edu	37	7	107423731	107423731	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr7:107423731G>A	ENST00000340010.5	-	9	1222	c.1038C>T	c.(1036-1038)atC>atT	p.I346I	SLC26A3_ENST00000422236.2_Silent_p.I311I	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	346					excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						CAACCATTGCGATGCCGAAGC	0.433000													17	78					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112237742	112237742	+	Missense_Mutation	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:112237742C>A	ENST00000261733.2	+	11	1342	c.1281C>A	c.(1279-1281)ttC>ttA	p.F427L	ALDH2_ENST00000416293.3_Missense_Mutation_p.F380L	NM_000690.3	NP_000681.2	P05091	ALDH2_HUMAN	aldehyde dehydrogenase 2 family (mitochondrial)	427					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity|electron carrier activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	22					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	TCCTGAAGTTCAAGACCATAG	0.557000			T	HMGA2	leiomyoma								15	26					1.3612e-06	1.42113e-06	1	1	0
PCNXL2	80003	broad.mit.edu	37	1	233394357	233394357	+	Silent	SNP	C	C	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:233394357C>A	ENST00000258229.8	-	5	1485	c.1251G>T	c.(1249-1251)gcG>gcT	p.A417A	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	417						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GAGAACCGGCCGCCCCTGGGT	0.567000													80	63					8.41775e-28	9.37817e-28	1	1	0
CACNA1D	776	broad.mit.edu	37	3	53736702	53736702	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:53736702C>T	ENST00000288139.3	+	9	1373	c.1255C>T	c.(1255-1257)Cgg>Tgg	p.R419W	CACNA1D_ENST00000350061.5_Missense_Mutation_p.R419W|CACNA1D_ENST00000422281.2_Missense_Mutation_p.R419W	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	419					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGCAAAAGCACGGGGAGATTT	0.522000													9	18					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89498522	89498522	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr3:89498522G>C	ENST00000336596.2	+	14	2719	c.2494G>C	c.(2494-2496)Gat>Cat	p.D832H	EPHA3_ENST00000494014.1_Missense_Mutation_p.D832H	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	832	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding	p.D832N(1)		NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTCCAATCAGGATGTAAGTAT	0.443000										TSP Lung(6;0.00050)			39	50					0	0	1	0	0
GPR152	390212	broad.mit.edu	37	11	67219685	67219685	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr11:67219685C>T	ENST00000312457.2	-	1	515	c.511G>A	c.(511-513)Gag>Aag	p.E171K		NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	171						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			ACGGCAGCCTCGGGGAAGACC	0.682000													12	51					0	0	1	0	0
NCAPD2	9918	broad.mit.edu	37	12	6637370	6637370	+	Silent	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr12:6637370C>T	ENST00000315579.5	+	25	3974	c.3175C>T	c.(3175-3177)Ctg>Ttg	p.L1059L	NCAPD2_ENST00000545962.1_Silent_p.L1014L	NM_014865.3	NP_055680.3	Q15021	CND1_HUMAN	non-SMC condensin I complex, subunit D2	1059					cell division|mitotic chromosome condensation	condensin core heterodimer|cytoplasm	histone binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	48						GCTTCGTCTTCTGTTCACCAT	0.527000													71	193					0	0	1	0	0
DTL	51514	broad.mit.edu	37	1	212273710	212273710	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:212273710C>G	ENST00000366991.4	+	14	1692	c.1378C>G	c.(1378-1380)Ctt>Gtt	p.L460V	DTL_ENST00000542077.1_Missense_Mutation_p.L418V|DTL_ENST00000475419.1_3'UTR	NM_016448.2	NP_057532.2	Q9NZJ0	DTL_HUMAN	denticleless E3 ubiquitin protein ligase homolog (Drosophila)	460					DNA replication|G2/M transition DNA damage checkpoint|protein monoubiquitination|protein polyubiquitination|response to UV|translesion synthesis|ubiquitin-dependent protein catabolic process	centrosome|Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|nuclear membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(6)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(81;0.00796)|all cancers(67;0.0385)|Epithelial(68;0.102)		AGACCTCCCTCTTCCTTCAAA	0.557000													5	91					0	0	1	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74818999	74818999	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:74818999C>G	ENST00000370895.1	+	12	1320	c.1285C>G	c.(1285-1287)Cag>Gag	p.Q429E	TNNI3K_ENST00000326637.3_Missense_Mutation_p.Q328E|RP11-439H8.4_ENST00000415549.2_RNA|TNNI3K_ENST00000370891.2_Missense_Mutation_p.Q429E|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.Q429E|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.Q429E			Q59H18	TNI3K_HUMAN		328						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TCTTCTTGATCAGAATGTCAT	0.368000													6	18					0	0	1	0	0
RSPO4	343637	broad.mit.edu	37	20	948618	948618	+	Silent	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr20:948618G>A	ENST00000217260.4	-	2	339	c.243C>T	c.(241-243)cgC>cgT	p.R81R	RSPO4_ENST00000400634.2_Silent_p.R81R	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	81					Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						CCTCCTGGCCGCGGATGCCGA	0.602000													39	41					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10529691	10529691	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr6:10529691C>T	ENST00000379597.3	+	1	1103	c.547C>T	c.(547-549)Ccc>Tcc	p.P183S	GCNT2_ENST00000495262.1_Missense_Mutation_p.P183S|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000397423.2_Intron			Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	183						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		CTCTGAAGTTCCCTGGAAGTA	0.493000													22	60					0	0	1	0	0
CDADC1	81602	broad.mit.edu	37	13	49852582	49852582	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr13:49852582G>A	ENST00000251108.6	+	7	1260	c.1147G>A	c.(1147-1149)Gac>Aac	p.D383N	CDADC1_ENST00000444959.1_Missense_Mutation_p.D185N	NM_001193478.1|NM_030911.3	NP_001180407.1|NP_112173.1	Q9BWV3	CDAC1_HUMAN	cytidine and dCMP deaminase domain containing 1	383							hydrolase activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|upper_aerodigestive_tract(1)	16		Lung NSC(96;0.000705)|Breast(56;0.0011)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;1.06e-08)|COAD - Colon adenocarcinoma(199;0.216)		ACACATGGATGACAAGCAGAA	0.403000													27	108					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713977	142713977	+	RNA	DEL	T	T	-			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:142713977delT	ENST00000369381.2	-	0	628																											ATCCATATACTAAAAAGGTTA	0.294													4	9	---	---	---	---					
RP11-435B5.5	0	broad.mit.edu	37	1	143391923	143391924	+	RNA	DEL	AT	AT	-			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr1:143391923_143391924delAT	ENST00000428624.1	+	0	2065				RP11-435B5.4_ENST00000423249.1_lincRNA																							TATTTTGGAGATATATATATAT	0.262													2	4	---	---	---	---					
GS1-124K5.2	0	broad.mit.edu	37	7	65888987	65888987	+	RNA	DEL	C	C	-	rs77289928		TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr7:65888987delC	ENST00000442578.1	-	0	826																											Ctttttttttctttttttttt	0.483													4	9	---	---	---	---					
RASA4B	100271927	broad.mit.edu	37	7	102147228	102147229	+	In_Frame_Ins	INS	-	-	TCG			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr7:102147228_102147229insTCG	ENST00000481893.1	-	10	1249_1250	c.125_126insCGA	c.(124-126)gga>gCGAga	p.42_42G>AR	RASA4B_ENST00000465829.1_In_Frame_Ins_p.114_114G>AR|RASA4B_ENST00000306682.6_In_Frame_Ins_p.42_42G>AR|RASA4B_ENST00000541662.1_In_Frame_Ins_p.114_114G>AR					RAS p21 protein activator 4B											skin(1)	1						CCTGCACCTCCTCGTCGGGGTC	0.698													3	4	---	---	---	---					
SNHG24	101929369	broad.mit.edu	37	14	101451259	101451259	+	RNA	DEL	T	T	-			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr14:101451259delT	ENST00000554693.2	+	0	886																											TAGAACATAATTTTTTTGGCA	0.328													9	23	---	---	---	---					
PLA2G4E	123745	broad.mit.edu	37	15	42280282	42280282	+	Frame_Shift_Del	DEL	A	A	-			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr15:42280282delA	ENST00000399518.3	-	16	2282	c.1796delT	c.(1795-1797)tcfs	p.F599fs	PLA2G4E_ENST00000413860.2_Frame_Shift_Del_p.F570fs|CTD-2382E5.1_ENST00000499478.2_RNA	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	587	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		CCACCTGTGGAAAAACTCCTC	0.612													2	4	---	---	---	---					
TBC1D21	161514	broad.mit.edu	37	15	74173755	74173755	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr15:74173755delC	ENST00000300504.2	+	2	159	c.76delC	c.(76-78)ccfs	p.P26fs	TBC1D21_ENST00000562056.1_Frame_Shift_Del_p.P26fs|TBC1D21_ENST00000535547.2_Intron	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	26						intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						GAGAAAACCACCCATTGACAA	0.443													17	38	---	---	---	---					
ZNF74	7625	broad.mit.edu	37	22	20759667	20759667	+	Splice_Site	DEL	A	A	-			TCGA-62-A471-01A-12D-A24D-08	TCGA-62-A471-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b68872bc-a341-4293-bf53-84ef0a0e3cfb	c634514e-679e-4fdb-a3ec-d2cabe170e9b	g.chr22:20759667delA	ENST00000400451.2	+	5	858	c.343_splice	c.e5-1	p.E115_splice	ZNF74_ENST00000356671.5_Splice_Site_p.E115_splice|ZNF74_ENST00000403682.3_Splice_Site_p.R86_splice|ZNF74_ENST00000405993.1_Splice_Site_p.E83_splice|ZNF74_ENST00000357502.5_Splice_Site_p.R120_splice	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	115					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TATCTTACAGAATGGGAGCTG	0.537													47	105	---	---	---	---