Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PCDHB6	56130	broad.mit.edu	37	5	140530708	140530708	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:140530708C>A	ENST00000231136.1	+	1	870	c.870C>A	c.(868-870)ttC>ttA	p.F290L	PCDHB6_ENST00000543635.1_Missense_Mutation_p.F154L	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		290	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCAACCCTTCGAAATAAACG	0.458000													26	46					2.61193e-14	2.80853e-14	1	1	0
PRPF3	9129	broad.mit.edu	37	1	150312943	150312943	+	Silent	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:150312943C>G	ENST00000324862.6	+	9	1437	c.1272C>G	c.(1270-1272)ctC>ctG	p.L424L	PRPF3_ENST00000414970.2_Silent_p.L375L|PRPF3_ENST00000543398.1_3'UTR|PRPF3_ENST00000467329.1_3'UTR	NM_004698.2	NP_004689.1	O43395	PRPF3_HUMAN	pre-mRNA processing factor 3	424					nuclear mRNA splicing, via spliceosome	Cajal body|cytoplasm|nuclear speck|spliceosomal complex	protein binding	p.L424L(1)		breast(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(24;5.57e-29)|Breast(34;0.000844)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)	Colorectal(1306;0.0149)		CAGCCCAGCTCAATCCTCCAG	0.373000													4	95					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178917495	178917495	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:178917495C>G	ENST00000263967.3	+	3	527	c.370C>G	c.(370-372)Cca>Gca	p.P124A		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	124					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.P124T(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TATCGGCATGCCAGTGTGTGA	0.348000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			33	61					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72132853	72132853	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:72132853C>T	ENST00000268482.3	+	6	1301	c.792C>T	c.(790-792)gaC>gaT	p.D264D	DHX38_ENST00000536867.1_Intron	NM_014003.3	NP_054722.2	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	264					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				ACTCGGATGACACGCCTCTGC	0.587000													5	30					0	0	1	0	0
EREG	2069	broad.mit.edu	37	4	75245174	75245174	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr4:75245174T>C	ENST00000244869.2	+	2	243	c.77T>C	c.(76-78)cTt>cCt	p.L26P		NM_001432.2	NP_001423.1	O14944	EREG_HUMAN	epiregulin	26					angiogenesis|cell-cell signaling|cytokine-mediated signaling pathway|epidermal growth factor receptor signaling pathway|female meiosis|keratinocyte differentiation|keratinocyte proliferation|luteinizing hormone signaling pathway|mRNA transcription|negative regulation of epithelial cell proliferation|negative regulation of smooth muscle cell differentiation|negative regulation of transcription, DNA-dependent|oocyte maturation|organ morphogenesis|ovarian cumulus expansion|ovulation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of DNA replication|positive regulation of epidermal growth factor receptor activity|positive regulation of fibroblast proliferation|positive regulation of innate immune response|positive regulation of interleukin-6 biosynthetic process|positive regulation of mitosis|positive regulation of phosphorylation|positive regulation of smooth muscle cell proliferation|primary follicle stage|wound healing	extracellular space|integral to plasma membrane	epidermal growth factor receptor binding|growth factor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(1)	13			Lung(101;0.196)			GGTTTCCATCTTCTACAGGCA	0.363000													31	146					0	0	1	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783693	149783693	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:149783693G>A	ENST00000427880.2	-	1	232	c.186C>T	c.(184-186)atC>atT	p.I62I	HIST2H2BF_ENST00000469483.1_5'UTR|HIST2H2BF_ENST00000369167.1_Silent_p.I62I|HIST2H2BF_ENST00000545683.1_Silent_p.I62I			Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf	62					nucleosome assembly	nucleosome|nucleus	DNA binding	p.I62I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	Breast(34;0.0124)|all_hematologic(923;0.127)					AGGAGTTCATGATGCCCATGG	0.612000													7	320					0	0	1	0	0
PLD1	5337	broad.mit.edu	37	3	171394539	171394539	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:171394539G>A	ENST00000356327.5	-	17	2037	c.1967C>T	c.(1966-1968)gCa>gTa	p.A656V	PLD1_ENST00000351298.4_Missense_Mutation_p.A694V|PLD1_ENST00000342215.6_Missense_Mutation_p.H585Y|PLD1_ENST00000340989.4_Missense_Mutation_p.A694V	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	694	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GAAGTGACGTGCCACATCACG	0.532000													50	68					0	0	1	0	0
CARD14	79092	broad.mit.edu	37	17	78171948	78171948	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:78171948G>C	ENST00000573882.1	+	14	2181	c.1645G>C	c.(1645-1647)Gat>Cat	p.D549H	CARD14_ENST00000570421.1_Missense_Mutation_p.D549H|CARD14_ENST00000573754.1_3'UTR|CARD14_ENST00000344227.2_Missense_Mutation_p.D549H|CARD14_ENST00000392434.2_Missense_Mutation_p.D312H			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	549					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			TGGAAGGCTTGATGTCTCGGA	0.602000													3	126					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176022672	176022672	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:176022672G>A	ENST00000510636.1	+	32	4206	c.3932G>A	c.(3931-3933)tGa>tAa	p.*1311*	CDHR2_ENST00000261944.5_Silent_p.*1311*|CDHR2_ENST00000506348.1_Silent_p.*1311*	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	0					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ACGGACCTGTGACAGGGGCCC	0.622000													5	146					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26951367	26951367	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:26951367A>T	ENST00000528896.2	-	25	4710	c.4636T>A	c.(4636-4638)Ttt>Att	p.F1546I	KIAA0100_ENST00000544884.1_Missense_Mutation_p.F1403I|KIAA0100_ENST00000389003.3_Missense_Mutation_p.F1403I	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1546				F -> L (in Ref. 4; CAI45940).		extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					AACACTACAAACCTATCTGTC	0.458000													23	61					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93617331	93617331	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:93617331C>A	ENST00000394236.3	-	8	1126	c.810G>T	c.(808-810)aaG>aaT	p.K270N	PROS1_ENST00000407433.1_Missense_Mutation_p.K139N	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	270	EGF-like 4; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TGAATCCTTTCTTCCCATCAC	0.378000													28	61					6.07407e-21	6.67481e-21	1	1	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367485.4_Silent_p.K617K|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367483.4_Silent_p.K669K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													4	141					0	0	1	0	0
CEP85L	387119	broad.mit.edu	37	6	118832571	118832571	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr6:118832571G>C	ENST00000368491.3	-	5	1768	c.1147C>G	c.(1147-1149)Caa>Gaa	p.Q383E	CEP85L_ENST00000368488.5_Missense_Mutation_p.Q386E|CEP85L_ENST00000392500.3_Missense_Mutation_p.Q386E|CEP85L_ENST00000419517.2_Missense_Mutation_p.Q383E|CEP85L_ENST00000360290.3_Missense_Mutation_p.Q281E	NM_001042475.2	NP_001035940.1	Q5SZL2	CF204_HUMAN	centrosomal protein 85kDa-like	383						centrosome											GTAATTTGTTGCTTCTGCCTG	0.353000													13	18					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158627401	158627401	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:158627401G>A	ENST00000368148.3	-	19	2851	c.2671C>T	c.(2671-2673)Cga>Tga	p.R891*	SPTA1_ENST00000368147.3_Nonsense_Mutation_p.R891*	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	891					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.R891*(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCATTTTGTCGCCTAGCAGCT	0.463000													54	180					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186383964	186383964	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:186383964C>T	ENST00000232003.4	+	1	224	c.144C>T	c.(142-144)ttC>ttT	p.F48F	HRG_ENST00000468154.1_3'UTR	NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	48	Cystatin 1.|Interaction with ATP5A1.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GCTACCTTTTCCAATTGCTGC	0.532000													6	150					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178917494	178917494	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:178917494G>T	ENST00000263967.3	+	3	526	c.369G>T	c.(367-369)atG>atT	p.M123I		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	123					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			CTATCGGCATGCCAGTGTGTG	0.348000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			34	60					4.0492e-12	4.30766e-12	1	1	0
ZNF578	147660	broad.mit.edu	37	19	53014946	53014946	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:53014946C>A	ENST00000421239.2	+	6	1556	c.1312C>A	c.(1312-1314)Cat>Aat	p.H438N	CTD-3099C6.5_ENST00000599143.1_RNA	NM_001099694.1	NP_001093164.1	Q96N58	ZN578_HUMAN	zinc finger protein 578	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H438Y(1)							GBM - Glioblastoma multiforme(134;0.00819)|OV - Ovarian serous cystadenocarcinoma(262;0.01)		GGCTTTTATTCATCAGTCAAG	0.383000													5	67					0.0215528	0.0217705	1	1	0
NOS1	4842	broad.mit.edu	37	12	117685288	117685288	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr12:117685288G>C	ENST00000317775.6	-	18	3373	c.2688C>G	c.(2686-2688)caC>caG	p.H896Q	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.H930Q	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	896	Flavodoxin-like.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	AGGCGCAAAAGTGAGGGTATG	0.557000													10	55					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152276983	152276983	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:152276983G>A	ENST00000368799.1	-	3	10414	c.10379C>T	c.(10378-10380)tCa>tTa	p.S3460L	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3460	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATGGGACCCTGAGTGTCCAGA	0.572000									Ichthyosis				10	787					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848794	73848794	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:73848794T>C	ENST00000523207.1	+	3	1792	c.1204T>C	c.(1204-1206)Tgt>Cgt	p.C402R		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	402					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			AGGTCTGTGCTGTATTGCTGG	0.433000													23	96					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40049523	40049523	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr20:40049523C>G	ENST00000373233.3	-	31	5929	c.5752G>C	c.(5752-5754)Gag>Cag	p.E1918Q		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1918					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TTTGCCACCTCTAAGCTTCCT	0.542000													4	89					0	0	1	0	0
EZH1	2145	broad.mit.edu	37	17	40855782	40855782	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:40855782C>A	ENST00000428826.2	-	19	2195	c.2074G>T	c.(2074-2076)Gtg>Ttg	p.V692L	EZH1_ENST00000585893.1_Missense_Mutation_p.V652L|EZH1_ENST00000435174.1_Missense_Mutation_p.V553L|EZH1_ENST00000415827.2_Missense_Mutation_p.V683L|EZH1_ENST00000592743.1_Missense_Mutation_p.V692L|EZH1_ENST00000590078.1_Missense_Mutation_p.V622L			Q92800	EZH1_HUMAN	enhancer of zeste homolog 1 (Drosophila)	692	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	chromatin binding|DNA binding			breast(1)|endometrium(4)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(2)	27		Breast(137;0.00104)		BRCA - Breast invasive adenocarcinoma(366;0.0784)		TTGGGATTCACTGAATGATTT	0.423000													10	90					7.03913e-09	7.33242e-09	1	1	0
MAGEA12	4111	broad.mit.edu	37	X	151899930	151899930	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:151899930G>C	ENST00000393900.3	-	3	1224	c.871C>G	c.(871-873)Cta>Gta	p.L291V	MAGEA12_ENST00000357916.4_Missense_Mutation_p.L291V|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.L291V	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	291	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CTGATCTTTAGCAAATGGTGC	0.562000													22	313					0	0	1	0	0
MFN2	9927	broad.mit.edu	37	1	12069782	12069782	+	Splice_Site	SNP	A	A	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:12069782A>C	ENST00000235329.5	+	18	2525	c.2204_splice	c.e18+1	p.R735_splice	MFN2_ENST00000444836.1_Splice_Site_p.R735_splice	NM_014874.3	NP_055689.1	O95140	MFN2_HUMAN	mitofusin 2	735					blood coagulation|mitochondrial fusion|mitochondrial membrane organization|mitochondrion localization|negative regulation of Ras protein signal transduction|negative regulation of smooth muscle cell proliferation|protein targeting to mitochondrion	cytosol|integral to membrane|intrinsic to mitochondrial outer membrane	GTP binding|GTPase activity|ubiquitin protein ligase binding			endometrium(4)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(2)	20	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.25e-06)|COAD - Colon adenocarcinoma(227;0.000302)|BRCA - Breast invasive adenocarcinoma(304;0.000329)|Kidney(185;0.000896)|KIRC - Kidney renal clear cell carcinoma(229;0.00274)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		AAAGCTGCTCAGGTGAGGCTG	0.572000													4	32					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111766638	111766638	+	Silent	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:111766638G>C	ENST00000452346.2	+	7	786	c.783G>C	c.(781-783)ccG>ccC	p.P261P	TMPRSS7_ENST00000419127.1_Silent_p.P135P			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	261	CUB 1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						TCCACTACCCGCTGGAGATTT	0.473000													11	81					0	0	1	0	0
HERC4	26091	broad.mit.edu	37	10	69684945	69684945	+	Splice_Site	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr10:69684945C>G	ENST00000395198.3	-	25	3110		c.e25-1		HERC4_ENST00000373700.4_Splice_Site|HERC4_ENST00000277817.6_Splice_Site|HERC4_ENST00000395187.2_Splice_Site|HERC4_ENST00000412272.2_Splice_Site	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4						cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						ATTCTGTATTCTAAAAACAAC	0.328000													11	22					0	0	1	0	0
PTGER4	5734	broad.mit.edu	37	5	40692463	40692463	+	Missense_Mutation	SNP	T	T	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:40692463T>G	ENST00000302472.3	+	3	2474	c.1450T>G	c.(1450-1452)Tca>Gca	p.S484A		NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	484					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						ACTGAACTTATCAGAAAAATG	0.458000													35	88					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73676583	73676583	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:73676583G>A	ENST00000264448.6	+	8	3037	c.2926G>A	c.(2926-2928)Gaa>Aaa	p.E976K	ALMS1_ENST00000377715.1_Missense_Mutation_p.E976K|ALMS1_ENST00000409009.1_Missense_Mutation_p.E934K	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	976	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TCTACCTAGAGAATCTCTGAA	0.463000													14	101					0	0	1	0	0
CYP4A11	1579	broad.mit.edu	37	1	47406939	47406939	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:47406939G>T	ENST00000310638.4	-	1	198	c.167C>A	c.(166-168)tCc>tAc	p.S56Y	CYP4A11_ENST00000371904.4_Missense_Mutation_p.S56Y|CYP4A11_ENST00000475477.1_5'UTR|CYP4A11_ENST00000457840.2_5'UTR|CYP4A11_ENST00000371905.1_Missense_Mutation_p.S56Y	NM_000778.3	NP_000769.2	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A, polypeptide 11	56					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			endometrium(2)|kidney(5)|large_intestine(6)|lung(6)|ovary(5)|prostate(3)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	36					NADH(DB00157)	GAGCCAGTGGGAGGGAGGGCA	0.597000													17	76					1.99824e-07	2.06004e-07	1	1	0
ALDH7A1	501	broad.mit.edu	37	5	125912887	125912887	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:125912887C>T	ENST00000409134.3	-	6	753	c.534G>A	c.(532-534)ctG>ctA	p.L178L	ALDH7A1_ENST00000413020.1_5'UTR|ALDH7A1_ENST00000447989.2_Silent_p.L205L|ALDH7A1_ENST00000553117.1_Silent_p.L178L	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	178					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	ACTGCTCAATCAGTGCATGGC	0.463000													7	45					0	0	1	0	0
C10orf90	118611	broad.mit.edu	37	10	128193347	128193347	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr10:128193347G>C	ENST00000284694.7	-	3	542	c.422C>G	c.(421-423)aCc>aGc	p.T141S	C10orf90_ENST00000368674.1_5'UTR|C10orf90_ENST00000544758.1_Missense_Mutation_p.T238S|C10orf90_ENST00000454341.1_Missense_Mutation_p.T141S|C10orf90_ENST00000356858.3_Missense_Mutation_p.T94S|C10orf90_ENST00000392694.1_Missense_Mutation_p.T94S	NM_001004298.2	NP_001004298.2	Q96M02	CJ090_HUMAN	chromosome 10 open reading frame 90	141										NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(19)|liver(1)|lung(29)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	65		all_epithelial(44;4.51e-05)|all_lung(145;0.0068)|Lung NSC(174;0.0105)|Colorectal(57;0.0848)|all_neural(114;0.0936)|Breast(234;0.203)		COAD - Colon adenocarcinoma(40;0.0442)|Colorectal(40;0.0479)		GGCCGTGATGGTGATGGATGC	0.677000											OREG0020616	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	52					0	0	1	0	0
CCDC37	348807	broad.mit.edu	37	3	126138959	126138959	+	Silent	SNP	A	A	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:126138959A>G	ENST00000393425.1	+	11	1071	c.972A>G	c.(970-972)acA>acG	p.T324T	CCDC37_ENST00000505024.1_Silent_p.T324T|CCDC37_ENST00000352312.1_Silent_p.T323T			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	323										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		GTCAGGGTACAAAGAAGCCCT	0.647000													3	27					0	0	1	0	0
MAN1A2	10905	broad.mit.edu	37	1	117910819	117910819	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:117910819C>T	ENST00000356554.3	+	1	749	c.14C>T	c.(13-15)gCc>gTc	p.A5V	MAN1A2_ENST00000482811.1_3'UTR	NM_006699.3	NP_006690.1	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	5					N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	27	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		ACTACCCCAGCCCTGCTGCCC	0.468000													13	82					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11595166	11595166	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:11595166C>A	ENST00000294484.6	+	19	3772	c.3634C>A	c.(3634-3636)Ctc>Atc	p.L1212I	PTCHD2_ENST00000389575.3_Missense_Mutation_p.L1212I|PTCHD2_ENST00000304391.6_Missense_Mutation_p.A98D	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1212					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GCTGCCCGTGCTCCTCAGCAT	0.687000													3	21					0.000602214	0.000614504	1	1	0
SCRIB	23513	broad.mit.edu	37	8	144892864	144892864	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:144892864C>G	ENST00000356994.2	-	12	1402	c.1396G>C	c.(1396-1398)Gag>Cag	p.E466Q	SCRIB_ENST00000377533.3_Missense_Mutation_p.E385Q|SCRIB_ENST00000320476.3_Missense_Mutation_p.E466Q	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	466	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			ACCCGCTTCTCAGCTGCAGCT	0.647000													15	273					0	0	1	0	0
PCDH12	51294	broad.mit.edu	37	5	141336054	141336054	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:141336054C>T	ENST00000231484.3	-	1	2573	c.1363G>A	c.(1363-1365)Gac>Aac	p.D455N		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	455	Cadherin 4.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCATTGTCGTTGATGTCA	0.483000													6	138					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752444	247752444	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:247752444G>A	ENST00000320065.1	+	1	783	c.783G>A	c.(781-783)atG>atA	p.M261I	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			tcatcttcatgtatctgcagC	0.473000													35	99					0	0	1	0	0
OR1K1	392392	broad.mit.edu	37	9	125563288	125563288	+	Missense_Mutation	SNP	G	G	A	rs138952318		TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:125563288G>A	ENST00000277309.2	+	1	919	c.887G>A	c.(886-888)cGc>cAc	p.R296H		NM_080859.1	NP_543135.1	Q8NGR3	OR1K1_HUMAN	olfactory receptor, family 1, subfamily K, member 1	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(8)|lung(2)|ovary(1)|skin(4)|stomach(1)	17						CTCTGGAATCGCGATGTACAG	0.602000													30	108					0	0	1	0	0
IGSF22	283284	broad.mit.edu	37	11	18743148	18743148	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr11:18743148G>A	ENST00000513874.1	-	4	451	c.312C>T	c.(310-312)agC>agT	p.S104S	RP11-1081L13.4_ENST00000527285.1_RNA	NM_173588.3	NP_775859.3	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	104	Ig-like 1.									NS(2)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(20)|ovary(4)|prostate(4)|skin(3)	56						TGGGGATGCCGCTCTCCCTCT	0.592000											OREG0020822	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	136					0	0	1	0	0
RALGDS	5900	broad.mit.edu	37	9	135982592	135982592	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:135982592G>A	ENST00000393160.3	-	7	1481	c.1128C>T	c.(1126-1128)cgC>cgT	p.R376R	RALGDS_ENST00000542690.1_Silent_p.R502R|RALGDS_ENST00000469972.1_5'UTR|RALGDS_ENST00000372047.3_Silent_p.R419R|RALGDS_ENST00000372062.3_Silent_p.R402R|RALGDS_ENST00000372050.3_Silent_p.R431R|RALGDS_ENST00000393157.3_Silent_p.R430R	NM_001042368.1	NP_001035827.1	Q12967	GNDS_HUMAN	ral guanine nucleotide dissociation stimulator	431					nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	Ral guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	10				OV - Ovarian serous cystadenocarcinoma(145;3.66e-06)|Epithelial(140;2.77e-05)		TGACAGTGGCGCGGATGGTGG	0.632000			T	CIITA	"""PMBL, Hodgkin Lymphona, """								4	122					0	0	1	0	0
DOPEY2	9980	broad.mit.edu	37	21	37633010	37633010	+	Silent	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr21:37633010T>C	ENST00000399151.3	+	24	5380	c.5295T>C	c.(5293-5295)ttT>ttC	p.F1765F		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	1765					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane				autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TGTTGCAGTTTTGCTATGCTT	0.388000													63	143					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:7578263G>A	ENST00000420246.2	-	6	718	c.586C>T	c.(586-588)Cga>Tga	p.R196*	TP53_ENST00000455263.2_Nonsense_Mutation_p.R196*|TP53_ENST00000574684.1_Intron|TP53_ENST00000445888.2_Nonsense_Mutation_p.R196*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R196*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R196*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R196*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	196	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(167)|p.R64*(14)|p.R103*(14)|p.0?(8)|p.R196fs*51(7)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196R(2)|p.I195fs*50(1)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I195fs*12(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	29					0	0	1	0	0
IL31RA	133396	broad.mit.edu	37	5	55164714	55164714	+	Nonsense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:55164714C>T	ENST00000396834.1	+	5	689	c.193C>T	c.(193-195)Cag>Tag	p.Q65*	IL31RA_ENST00000396836.2_Nonsense_Mutation_p.Q84*|IL31RA_ENST00000359040.5_Nonsense_Mutation_p.Q84*|IL31RA_ENST00000297015.3_Intron|IL31RA_ENST00000447346.2_Nonsense_Mutation_p.Q84*|IL31RA_ENST00000490985.1_5'UTR|IL31RA_ENST00000354961.4_Nonsense_Mutation_p.Q65*	NM_001242638.1	NP_001229567.1	Q8NI17	IL31R_HUMAN	interleukin 31 receptor A	52	Fibronectin type-III 1.				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)	21		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				CAGTTATACCCAGTACACAGT	0.433000													13	88					0	0	1	0	0
EMC2	9694	broad.mit.edu	37	8	109491251	109491251	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:109491251C>T	ENST00000220853.3	+	10	754	c.719C>T	c.(718-720)gCt>gTt	p.A240V	EMC2_ENST00000520294.1_3'UTR	NM_014673.3	NP_055488.1			ER membrane protein complex subunit 2																		AGTCATATTGCTTCTAATCCA	0.328000													13	56					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167277997	167277997	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:167277997C>T	ENST00000308378.3	-	5	811	c.506G>A	c.(505-507)gGg>gAg	p.G169E	WDR49_ENST00000453925.2_Missense_Mutation_p.G222E|WDR49_ENST00000476376.1_5'UTR|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	169										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						AACAGTAGACCCTGTATCAGA	0.378000													11	43					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45262694	45262694	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:45262694C>T	ENST00000164227.5	+	9	1431	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	396	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				GGTCTTCTCTCCGCATCACCA	0.622000			T	IGH@	CLL								21	310					0	0	1	0	0
WAS	7454	broad.mit.edu	37	X	48545338	48545338	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:48545338G>T	ENST00000376701.4	+	7	803	c.728G>T	c.(727-729)gGa>gTa	p.G243V	WAS_ENST00000483750.1_3'UTR	NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	243	CRIB.				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				GCACCCAGTGGATTCAAGTGA	0.552000			"""Mis, N, F, S"""			lymphoma							4	4					0.184627	0.184627	1	1	0
NEBL	10529	broad.mit.edu	37	10	21115407	21115407	+	Missense_Mutation	SNP	C	C	T	rs151035799	byFrequency	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr10:21115407C>T	ENST00000377122.4	-	18	2234	c.1838G>A	c.(1837-1839)cGa>cAa	p.R613Q	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	613					regulation of actin filament length		actin binding|structural constituent of muscle	p.R613L(1)		NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						TTTCTTCACTCGTTCGATCTC	0.323000													5	167					0	0	1	0	0
MERTK	10461	broad.mit.edu	37	2	112777075	112777075	+	Missense_Mutation	SNP	G	G	T	rs147779020	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:112777075G>T	ENST00000295408.4	+	16	2422	c.2165G>T	c.(2164-2166)cGa>cTa	p.R722L	MERTK_ENST00000409780.1_Missense_Mutation_p.R546L|MERTK_ENST00000421804.2_Missense_Mutation_p.R722L			Q12866	MERTK_HUMAN	c-mer proto-oncogene tyrosine kinase	722	Protein kinase.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|liver(1)|lung(18)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(10)	46						TTTCTTCATCGAGATTTAGCT	0.463000													38	48					1.23103e-26	1.36781e-26	1	1	0
BRSK1	84446	broad.mit.edu	37	19	55814114	55814114	+	Missense_Mutation	SNP	C	C	T	rs144130246		TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:55814114C>T	ENST00000309383.1	+	10	1184	c.907C>T	c.(907-909)Cgg>Tgg	p.R303W	BRSK1_ENST00000590333.1_Missense_Mutation_p.R319W|BRSK1_ENST00000585418.1_Missense_Mutation_p.R303W|BRSK1_ENST00000326848.7_5'UTR	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	303			R -> W (in a gastric adenocarcinoma sample; somatic mutation).		establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.R303W(3)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCCTGGCCGCCGGGTAGCCAT	0.632000													4	49					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38908865	38908865	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:38908865G>A	ENST00000450244.1	-	23	4096	c.3898C>T	c.(3898-3900)Ctg>Ttg	p.L1300L	SCN11A_ENST00000444237.2_Silent_p.L1300L|SCN11A_ENST00000456224.3_Silent_p.L1262L|SCN11A_ENST00000302328.3_Silent_p.L1300L			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1300					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGAGATTCAGAGTGAAGAAT	0.363000													17	42					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55719074	55719074	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:55719074C>G	ENST00000379906.2	+	4	919	c.664C>G	c.(664-666)Cac>Gac	p.H222D	SLC6A2_ENST00000219833.8_Missense_Mutation_p.H222D|SLC6A2_ENST00000567238.1_Missense_Mutation_p.H117D|SLC6A2_ENST00000568943.1_Missense_Mutation_p.H222D|SLC6A2_ENST00000566163.1_Missense_Mutation_p.H222D|SLC6A2_ENST00000561820.1_Missense_Mutation_p.H222D|SLC6A2_ENST00000414754.3_Missense_Mutation_p.H222D	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	222					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CCTGCACCTTCACGAGAGCAG	0.597000													4	37					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152363473	152363473	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr2:152363473C>T	ENST00000397345.3	-	163	23708	c.23506G>A	c.(23506-23508)Gac>Aac	p.D7836N	NEB_ENST00000409198.1_Missense_Mutation_p.D6135N|NEB_ENST00000509223.2_5'UTR|NEB_ENST00000603639.1_Missense_Mutation_p.D7836N|NEB_ENST00000427231.2_Missense_Mutation_p.D7836N|NEB_ENST00000172853.10_Missense_Mutation_p.D6135N|NEB_ENST00000604864.1_Missense_Mutation_p.D7836N	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6135					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTGGCGTGTCTTGAACAACT	0.323000													20	32					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30671278	30671278	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr6:30671278C>T	ENST00000376406.3	-	11	6246	c.5599G>A	c.(5599-5601)Gac>Aac	p.D1867N	MDC1_ENST00000376405.2_Missense_Mutation_p.D1603N|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1867	Required for nuclear localization (NLS2).				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TCTGCCTGGTCTCTCTTTCTC	0.493000								Other conserved DNA damage response genes					6	152					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119903720	119903720	+	Silent	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:119903720C>G	ENST00000313400.4	-	4	1153	c.1053G>C	c.(1051-1053)ctG>ctC	p.L351L	ASTN2_ENST00000361209.2_Intron|ASTN2_ENST00000373996.3_Silent_p.L351L|ASTN2_ENST00000361477.3_Intron			O75129	ASTN2_HUMAN	astrotactin 2	351						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						ACTTCTGCATCAGGGACTCCA	0.592000													24	74					0	0	1	0	0
WDR52	55779	broad.mit.edu	37	3	113115417	113115417	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:113115417G>A	ENST00000393845.2	-	14	1793	c.1727C>T	c.(1726-1728)gCt>gTt	p.A576V	WDR52_ENST00000475568.1_5'UTR|WDR52_ENST00000295868.2_Missense_Mutation_p.A576V	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	576										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						AGTGACACAAGCAGTATGGGG	0.383000													6	103					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	118950344	118950344	+	Missense_Mutation	SNP	C	C	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:118950344C>A	ENST00000328252.3	+	2	1696	c.1327C>A	c.(1327-1329)Ctg>Atg	p.L443M		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	443	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TTGCCGCCACCTGCGCCACCC	0.587000													26	77					3.65163e-15	3.96916e-15	1	1	0
CAMK2B	816	broad.mit.edu	37	7	44274242	44274242	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:44274242A>T	ENST00000395749.2	-	14	1131	c.1055T>A	c.(1054-1056)gTc>gAc	p.V352D	CAMK2B_ENST00000395747.2_Missense_Mutation_p.V328D|CAMK2B_ENST00000353625.4_Missense_Mutation_p.V328D|CAMK2B_ENST00000358707.3_Missense_Mutation_p.V328D|CAMK2B_ENST00000350811.3_Missense_Mutation_p.V352D|CAMK2B_ENST00000347193.4_Missense_Mutation_p.V352D|CAMK2B_ENST00000346990.4_Intron|CAMK2B_ENST00000258682.6_Missense_Mutation_p.V327D|CAMK2B_ENST00000457475.1_Missense_Mutation_p.V328D|CAMK2B_ENST00000440254.2_Missense_Mutation_p.V352D|CAMK2B_ENST00000502837.2_Missense_Mutation_p.V223D	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	352					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						CCTCACCTTGACTCCATCTGC	0.647000													14	28					0	0	1	0	0
ITGA5	3678	broad.mit.edu	37	12	54797513	54797513	+	Missense_Mutation	SNP	G	G	A	rs143754928	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr12:54797513G>A	ENST00000293379.4	-	17	1933	c.1672C>T	c.(1672-1674)Cgg>Tgg	p.R558W	RP11-753H16.5_ENST00000552785.1_RNA|RP11-753H16.3_ENST00000550474.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	558					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AGTGCCCGCCGTACCCCTCCC	0.547000													10	56					0	0	1	0	0
ZNFX1	57169	broad.mit.edu	37	20	47887961	47887961	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr20:47887961G>C	ENST00000396105.1	-	3	634	c.388C>G	c.(388-390)Ccc>Gcc	p.P130A	ZNFX1_ENST00000371754.4_Missense_Mutation_p.P130A|ZNFX1_ENST00000371752.1_Missense_Mutation_p.P130A	NM_021035.2	NP_066363.1	Q9P2E3	ZNFX1_HUMAN	zinc finger, NFX1-type containing 1	130							metal ion binding			cervix(2)|endometrium(8)|kidney(7)|large_intestine(15)|liver(1)|lung(17)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	60			BRCA - Breast invasive adenocarcinoma(12;0.00173)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			TTCTGGTGGGGAGTCCGCCAC	0.527000													5	203					0	0	1	0	0
OR1C1	26188	broad.mit.edu	37	1	247921555	247921555	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:247921555C>G	ENST00000408896.2	-	1	427	c.154G>C	c.(154-156)Gac>Cac	p.D52H		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AGGTGAGAGTCAAAGCCAATC	0.473000													3	49					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233296064	233296064	+	Missense_Mutation	SNP	A	A	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:233296064A>T	ENST00000258229.8	-	19	3716	c.3482T>A	c.(3481-3483)cTc>cAc	p.L1161H	PCNXL2_ENST00000488780.2_Missense_Mutation_p.L294H|PCNXL2_ENST00000520463.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1161						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TTTGTTTTTGAGAATGGGGTG	0.443000													5	49					0	0	1	0	0
PGAM4	441531	broad.mit.edu	37	X	77224607	77224607	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:77224607C>G	ENST00000458128.1	-	1	528	c.529G>C	c.(529-531)Gag>Cag	p.E177Q	ATP7A_ENST00000343533.5_Intron|ATP7A_ENST00000341514.6_Intron|ATP7A_ENST00000350425.4_Intron	NM_001029891.2	NP_001025062.1	Q8N0Y7	PGAM4_HUMAN	phosphoglycerate mutase family member 4	177					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity			endometrium(2)|lung(4)	6						CGTTTCCCCTCCTTGATCTGG	0.517000													10	87					0	0	1	0	0
SLC39A11	201266	broad.mit.edu	37	17	71027795	71027795	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:71027795G>A	ENST00000542342.2	-	4	294	c.206C>T	c.(205-207)tCc>tTc	p.S69F	SLC39A11_ENST00000255559.3_Missense_Mutation_p.S69F|SLC39A11_ENST00000579732.1_Missense_Mutation_p.S69F	NM_001159770.1	NP_001153242.1	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11	69					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			endometrium(1)|large_intestine(4)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16						GCCCCCAGAGGACGTGGCCAT	0.532000													25	33					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247464553	247464553	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:247464553C>G	ENST00000294753.4	-	9	1496	c.1032G>C	c.(1030-1032)gaG>gaC	p.E344D	ZNF496_ENST00000366498.2_Missense_Mutation_p.E380D|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	344					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CCAGGCTGTTCTCTAGAGATC	0.617000													3	106					0	0	1	0	0
PBX3	5090	broad.mit.edu	37	9	128691974	128691974	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:128691974G>T	ENST00000373487.4	+	4	637	c.557G>T	c.(556-558)cGa>cTa	p.R186L	PBX3_ENST00000538998.1_3'UTR|PBX3_ENST00000373489.5_Missense_Mutation_p.R186L|PBX3_ENST00000373483.2_Missense_Mutation_p.R5L|PBX3_ENST00000447726.2_Missense_Mutation_p.R111L|PBX3_ENST00000342287.5_Missense_Mutation_p.R186L			P40426	PBX3_HUMAN	pre-B-cell leukemia homeobox 3	186					anterior compartment pattern formation|posterior compartment specification		sequence-specific DNA binding transcription factor activity			biliary_tract(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|upper_aerodigestive_tract(2)	24						AACCTTCTCCGAGAACAGAGT	0.383000													32	92					2.54651e-27	2.86124e-27	1	1	0
TADA2A	6871	broad.mit.edu	37	17	35830541	35830541	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:35830541G>A	ENST00000394395.2	+	13	1106	c.933G>A	c.(931-933)gaG>gaA	p.E311E	TADA2A_ENST00000591992.1_3'UTR|TADA2A_ENST00000225396.6_Silent_p.E311E	NM_001166105.1	NP_001159577.1	O75478	TAD2A_HUMAN	transcriptional adaptor 2A	311					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|lung(3)|prostate(1)|skin(1)	13						AGACACGGGAGGAAGAGCGCC	0.517000													28	148					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52356644	52356644	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr15:52356644G>C	ENST00000261845.5	+	6	2420	c.1613G>C	c.(1612-1614)aGt>aCt	p.S538T	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	538					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		ATTCAGCTTAGTTCCCAGCAT	0.383000													10	12					0	0	1	0	0
C1orf116	79098	broad.mit.edu	37	1	207196808	207196808	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:207196808T>C	ENST00000359470.5	-	4	550	c.301A>G	c.(301-303)Atc>Gtc	p.I101V	C1orf116_ENST00000461135.2_5'UTR	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	101						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					TGCTGAGTGATGGTCTCCTCT	0.567000													14	45					0	0	1	0	0
TRIM35	23087	broad.mit.edu	37	8	27145561	27145561	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:27145561G>A	ENST00000305364.4	-	6	1071	c.988C>T	c.(988-990)Cgc>Tgc	p.R330C	TRIM35_ENST00000521253.1_3'UTR	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	330	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding			breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		ACCTGCACGCGGTAGCCATGG	0.657000													3	57					0	0	1	0	0
ZNF860	344787	broad.mit.edu	37	3	32032046	32032046	+	Missense_Mutation	SNP	G	G	A	rs143925165	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:32032046G>A	ENST00000360311.4	+	2	2024	c.1475G>A	c.(1474-1476)cGt>cAt	p.R492H		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	492					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCGTCACAATTCA	0.403000													4	109					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51791717	51791717	+	Missense_Mutation	SNP	G	G	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr15:51791717G>T	ENST00000251076.5	-	18	3991	c.3704C>A	c.(3703-3705)tCt>tAt	p.S1235Y	DMXL2_ENST00000449909.3_Intron|DMXL2_ENST00000543779.2_Missense_Mutation_p.S1235Y	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1235						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		CAAGTCTATAGATCTAAGAAG	0.423000													7	102					5.4927e-09	5.78179e-09	1	1	0
MUC17	140453	broad.mit.edu	37	7	100686290	100686290	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:100686290C>T	ENST00000306151.4	+	3	11657	c.11593C>T	c.(11593-11595)Cgt>Tgt	p.R3865C		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3865						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CACTACCATACGTATTTCAAT	0.493000													19	133					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81688716	81688716	+	Silent	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr12:81688716T>C	ENST00000550584.2	-	23	3118	c.2823A>G	c.(2821-2823)agA>agG	p.R941R	RP11-121G22.3_ENST00000549161.1_lincRNA|PPFIA2_ENST00000407050.4_Silent_p.R867R|PPFIA2_ENST00000550359.2_Silent_p.R788R|PPFIA2_ENST00000549396.1_Silent_p.R941R|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Silent_p.R926R|PPFIA2_ENST00000548586.1_Silent_p.R941R|PPFIA2_ENST00000443686.3_Silent_p.R842R|PPFIA2_ENST00000541017.1_Silent_p.R158R|PPFIA2_ENST00000541570.2_Silent_p.R508R|PPFIA2_ENST00000552948.1_Silent_p.R941R|PPFIA2_ENST00000333447.7_Silent_p.R926R	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	867										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TTCCAATTTCTCTCTGGATCT	0.493000													5	32					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108110646	108110646	+	Silent	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr3:108110646C>G	ENST00000273353.3	-	38	5507	c.5451G>C	c.(5449-5451)ctG>ctC	p.L1817L		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1817						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TACTCCCCATCAGGGCCATCT	0.473000													5	247					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69693761	69693761	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:69693761C>G	ENST00000349945.1	+	8	2598	c.1046C>G	c.(1045-1047)tCc>tGc	p.S349C	NFAT5_ENST00000566899.1_Missense_Mutation_p.S349C|NFAT5_ENST00000567239.1_Missense_Mutation_p.S443C|NFAT5_ENST00000354436.2_Missense_Mutation_p.S425C|NFAT5_ENST00000432919.1_Missense_Mutation_p.S443C|NFAT5_ENST00000393742.2_Missense_Mutation_p.S349C	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	425	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						AAAGATGGCTCCACTTTGACA	0.388000													14	102					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81123237	81123237	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr4:81123237C>T	ENST00000339711.4	+	10	1852	c.621C>T	c.(619-621)ggC>ggT	p.G207G	PRDM8_ENST00000415738.2_Silent_p.G207G|PRDM8_ENST00000504452.1_Silent_p.G207G	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	207	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcggcggcggcggtggcaaag	0.657000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	27					0	0	1	0	0
INSL5	10022	broad.mit.edu	37	1	67263711	67263711	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:67263711C>G	ENST00000304526.2	-	2	427	c.393G>C	c.(391-393)ttG>ttC	p.L131F		NM_005478.4	NP_005469.2	Q9Y5Q6	INSL5_HUMAN	insulin-like 5	131						extracellular region	hormone activity			breast(2)|endometrium(1)|lung(5)	8						AAAGAGCACTCAAATCAGTCA	0.403000													9	54					0	0	1	0	0
TLR5	7100	broad.mit.edu	37	1	223285659	223285659	+	Missense_Mutation	SNP	T	T	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:223285659T>C	ENST00000540964.1	-	4	1176	c.715A>G	c.(715-717)Aca>Gca	p.T239A	TLR5_ENST00000342210.6_Missense_Mutation_p.T239A			O60602	TLR5_HUMAN	toll-like receptor 5	239					cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		ATGTCCACTGTCCAGCCATTT	0.468000													3	92					0	0	1	0	0
NUP43	348995	broad.mit.edu	37	6	150064827	150064827	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr6:150064827C>T	ENST00000340413.2	-	3	344	c.268G>A	c.(268-270)Gct>Act	p.A90T	NUP43_ENST00000367403.3_Missense_Mutation_p.A151T|NUP43_ENST00000460354.2_Missense_Mutation_p.A90T|NUP43_ENST00000367404.4_Missense_Mutation_p.A90T|NUP43_ENST00000463048.3_5'UTR	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	90					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		GATGAAGCAGCGACAATTCTT	0.323000													11	35					0	0	1	0	0
MED1	5469	broad.mit.edu	37	17	37565808	37565808	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:37565808C>G	ENST00000300651.6	-	17	2889	c.2666G>C	c.(2665-2667)aGt>aCt	p.S889T	MED1_ENST00000394287.3_Intron	NM_004774.3	NP_004765.2	Q15648	MED1_HUMAN	mediator complex subunit 1	889	Interaction with ESR1.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			NS(1)|breast(2)|cervix(3)|kidney(3)|large_intestine(7)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(7)|urinary_tract(1)	59		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		ATTATCCCCACTTTGGCTGCT	0.398000										HNSCC(31;0.082)			48	207					0	0	1	0	0
UBXN2B	137886	broad.mit.edu	37	8	59358506	59358506	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr8:59358506G>C	ENST00000399598.2	+	7	834	c.712G>C	c.(712-714)Gag>Cag	p.E238Q		NM_001077619.1	NP_001071087.1	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	238						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	13						CTCTCCAGAAGAGGAGGATAA	0.348000													4	74					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													4	60					0	0	1	0	0
DACT1	51339	broad.mit.edu	37	14	59113480	59113480	+	Silent	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr14:59113480C>T	ENST00000395153.3	+	4	2175	c.2028C>T	c.(2026-2028)taC>taT	p.Y676Y	DACT1_ENST00000335867.4_Silent_p.Y713Y|DACT1_ENST00000395151.3_Silent_p.Y432Y|DACT1_ENST00000556859.1_Silent_p.Y432Y|DACT1_ENST00000541264.2_Silent_p.Y432Y	NM_001079520.1|NM_016651.5	NP_001072988.1|NP_057735.2	Q9NYF0	DACT1_HUMAN	dishevelled-binding antagonist of beta-catenin 1	713					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(7)|kidney(3)|large_intestine(11)|lung(27)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	53						CTCTGCCCTACGCCAGCCCCT	0.672000													47	40					0	0	1	0	0
ANKRD20A11P	391267	broad.mit.edu	37	21	15326403	15326403	+	RNA	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr21:15326403G>C	ENST00000344693.5	-	0	804					NR_027270.1																						CTTTTCCATTGACTATTCTGT	0.433000													7	110					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52496695	52496695	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:52496695C>T	ENST00000602063.1	-	6	1983	c.1634G>A	c.(1633-1635)tGt>tAt	p.C545Y	ZNF615_ENST00000376716.5_Missense_Mutation_p.C545Y|ZNF615_ENST00000391795.3_Missense_Mutation_p.C550Y|ZNF615_ENST00000598071.1_Missense_Mutation_p.C556Y|ZNF615_ENST00000594083.1_Missense_Mutation_p.C556Y			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	545					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GCCTTTTCCACACTCATTGCA	0.438000													11	94					0	0	1	0	0
PDPN	10630	broad.mit.edu	37	1	13940881	13940881	+	Missense_Mutation	SNP	A	A	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:13940881A>G	ENST00000294489.6	+	5	1026	c.685A>G	c.(685-687)Atg>Gtg	p.M229V	PDPN_ENST00000513143.1_Missense_Mutation_p.M111V|PDPN_ENST00000376061.4_Missense_Mutation_p.M111V|PDPN_ENST00000487038.1_Missense_Mutation_p.M111V|PDPN_ENST00000475043.1_Missense_Mutation_p.M111V|PDPN_ENST00000509009.1_Missense_Mutation_p.M148V|PDPN_ENST00000376057.4_Missense_Mutation_p.M229V			Q86YL7	PDPN_HUMAN	podoplanin	153					cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	16	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CGTTGTGGTTATGCGAAAAAT	0.423000													20	96					0	0	1	0	0
TBC1D25	4943	broad.mit.edu	37	X	48419138	48419138	+	Silent	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chrX:48419138G>A	ENST00000376771.4	+	6	2183	c.1842G>A	c.(1840-1842)ggG>ggA	p.G614G	TBC1D25_ENST00000537536.1_Silent_p.G360G|TBC1D25_ENST00000427713.1_3'UTR	NM_002536.2	NP_002527.1	Q3MII6	TBC25_HUMAN	TBC1 domain family, member 25	614						intracellular	Rab GTPase activator activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4						TTGGCCGGGGGAACCCATTCA	0.602000													8	111					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15795668	15795668	+	Missense_Mutation	SNP	G	G	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:15795668G>C	ENST00000550308.1	+	8	1341	c.961G>C	c.(961-963)Gag>Cag	p.E321Q	CYP4F12_ENST00000324632.9_Missense_Mutation_p.E321Q	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					TATAAGAGCAGAGGCTGACAC	0.527000													4	73					0	0	1	0	0
SNX13	23161	broad.mit.edu	37	7	17838335	17838335	+	Missense_Mutation	SNP	C	C	G			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr7:17838335C>G	ENST00000409389.1	-	24	2696	c.2524G>C	c.(2524-2526)Gcc>Ccc	p.A842P	SNX13_ENST00000428135.3_Missense_Mutation_p.A831P|SNX13_ENST00000496855.1_5'UTR			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	842					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					ACTGAGTCGGCTACTTGTTCA	0.333000													6	13					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43239971	43239971	+	Missense_Mutation	SNP	C	C	T			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr21:43239971C>T	ENST00000422911.1	-	19	2499	c.2398G>A	c.(2398-2400)Gtc>Atc	p.V800I	PRDM15_ENST00000538201.1_Missense_Mutation_p.V763I|PRDM15_ENST00000269844.3_Missense_Mutation_p.V1109I|PRDM15_ENST00000398548.1_Missense_Mutation_p.V780I|PRDM15_ENST00000447207.2_Missense_Mutation_p.V743I			P57071	PRD15_HUMAN	PR domain containing 15	1109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TACTCGCGGACATTGTCGTGC	0.622000													20	36					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176317899	176317899	+	Missense_Mutation	SNP	G	G	A	rs113978418	byFrequency	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:176317899G>A	ENST00000292432.5	-	5	549	c.458C>T	c.(457-459)gCg>gTg	p.A153V		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	153	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACAGGCTGCGCATCCAGGAA	0.597000													26	74					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237791371	237791371	+	Missense_Mutation	SNP	G	G	A			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:237791371G>A	ENST00000366574.2	+	41	6748	c.6431G>A	c.(6430-6432)cGt>cAt	p.R2144H	RYR2_ENST00000360064.6_Missense_Mutation_p.R2142H|RYR2_ENST00000542537.1_Missense_Mutation_p.R2128H	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2144	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTCATGATTCGTGGATTAGGG	0.408000													21	39					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33988994	33988994	+	Missense_Mutation	SNP	C	C	T	rs112150520	by1000genomes	TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr9:33988994C>T	ENST00000379238.1	-	5	536	c.419G>A	c.(418-420)aGa>aAa	p.R140K	UBAP2_ENST00000418786.2_Missense_Mutation_p.R140K|UBAP2_ENST00000539807.1_Intron|UBAP2_ENST00000449054.1_Missense_Mutation_p.R140K|UBAP2_ENST00000379239.4_5'UTR|UBAP2_ENST00000360802.1_Missense_Mutation_p.R140K			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	140										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		ATTGCCGCCTCTTCCTTTCCG	0.428000													9	139					0	0	1	0	0
EXO1	9156	broad.mit.edu	37	1	242035540	242035540	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr1:242035540delG	ENST00000366548.3	+	12	2067	c.1474delG	c.(1474-1476)aafs	p.E493fs	EXO1_ENST00000518483.1_Frame_Shift_Del_p.E493fs|EXO1_ENST00000348581.5_Frame_Shift_Del_p.E493fs	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	493					meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			AAGGAAAAATGAAGAAAGTGG	0.388								Editing and processing nucleases					37	189	---	---	---	---					
SUDS3P1	285647	broad.mit.edu	37	5	177398373	177398396	+	RNA	DEL	AGGACGAAGAGCTGGAGAGCGCCA	AGGACGAAGAGCTGGAGAGCGCCA	-	rs70994948		TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr5:177398373_177398396delAGGACGAAGAGCTGGAGAGCGCCA	ENST00000511650.1	+	0	145																											GTCCCCGGGGAGGACGAAGAGCTGGAGAGCGCCAAGGACGACGA	0.683													5	2	---	---	---	---					
MMP2	4313	broad.mit.edu	37	16	55513411	55513411	+	Frame_Shift_Del	DEL	G	G	-			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr16:55513411delG	ENST00000219070.4	+	1	529	c.20delG	c.(19-21)cgfs	p.R7fs	MMP2_ENST00000570308.1_Intron	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	7					angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CTAATGGCCCGGGGCGCGCTC	0.751													2	4	---	---	---	---					
MARK4	57787	broad.mit.edu	37	19	45801106	45801106	+	Frame_Shift_Del	DEL	C	C	-			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr19:45801106delC	ENST00000300843.4	+	15	2068	c.1771delC	c.(1771-1773)ccfs	p.P592fs	MARK4_ENST00000262891.4_Frame_Shift_Del_p.P592fs	NM_031417.3	NP_113605.2	Q96L34	MARK4_HUMAN	MAP/microtubule affinity-regulating kinase 4	592					microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			NS(1)|biliary_tract(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	31		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GCAGAATGGGCCCCCTGCCTC	0.711													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-73-7499-01A-11D-2184-08	TCGA-73-7499-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9d27ab8c-983c-42e2-a958-7d1c2e1565e5	590a8323-5e25-40df-a126-aea41cdd600e	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													6	13	---	---	---	---