Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
LILRB4	11006	broad.mit.edu	37	19	55177869	55177869	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:55177869G>A	ENST00000391736.1	+	11	1285	c.970G>A	c.(970-972)Gtc>Atc	p.V324I	LILRB4_ENST00000270452.2_Missense_Mutation_p.V324I|LILRB4_ENST00000391733.3_Missense_Mutation_p.V324I|LILRB4_ENST00000391734.3_Missense_Mutation_p.V324I|LILRB4_ENST00000430952.2_Missense_Mutation_p.V324I	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	324						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		AGCTGCTGACGTCCAGGGAGA	0.582000													5	47					0	0	0.000602	0	0
OR10G2	26534	broad.mit.edu	37	14	22102940	22102940	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr14:22102940C>A	ENST00000542433.1	-	1	156	c.59G>T	c.(58-60)gGt>gTt	p.G20V		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GTGAGACAAACCCAGAAGAAT	0.463000													10	97					2.80697e-09	6.00791e-09	0.010729	1	0
ZNF208	7757	broad.mit.edu	37	19	22171640	22171640	+	Silent	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:22171640C>T	ENST00000397126.4	-	2	223	c.75G>A	c.(73-75)caG>caA	p.Q25Q	ZNF208_ENST00000597040.1_5'UTR|ZNF208_ENST00000599916.1_Silent_p.Q25Q|ZNF208_ENST00000601773.1_Silent_p.Q25Q	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATAAATTCTGCTGTGCAGTGT	0.398000													7	118					0	0	0.004482	0	0
FCRL5	83416	broad.mit.edu	37	1	157490931	157490931	+	Silent	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr1:157490931C>T	ENST00000361835.3	-	11	2548	c.2391G>A	c.(2389-2391)tcG>tcA	p.S797S	FCRL5_ENST00000356953.4_Silent_p.S797S|FCRL5_ENST00000461387.1_5'UTR	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	797	Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				CAGAGGGGGACGACCTATTTC	0.592000													15	113					0	0	0.004990	0	0
ADCY6	112	broad.mit.edu	37	12	49166147	49166147	+	Silent	SNP	C	C	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr12:49166147C>A	ENST00000307885.4	-	17	3412	c.2718G>T	c.(2716-2718)gcG>gcT	p.A906A	ADCY6_ENST00000550422.1_Silent_p.A853A|ADCY6_ENST00000357869.3_Silent_p.A853A	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	906					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						ACAGCGCCAGCGCAAACACCA	0.562000													6	60					3.59834e-05	7.0806e-05	0.001168	1	0
SUV39H2	79723	broad.mit.edu	37	10	14939251	14939251	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr10:14939251A>G	ENST00000313519.5	+	2	635	c.404A>G	c.(403-405)gAt>gGt	p.D135G	SUV39H2_ENST00000354919.6_Missense_Mutation_p.D195G|SUV39H2_ENST00000378325.3_Intron	NM_001193425.1|NM_024670.3	NP_001180354.1|NP_078946.1	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2 (Drosophila)	195					cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)	19						TCATGCACAGATTGCTTCTTT	0.393000													9	81					0	0	0.006214	0	0
BTN1A1	696	broad.mit.edu	37	6	26509081	26509081	+	Silent	SNP	C	C	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr6:26509081C>A	ENST00000244513.6	+	7	1326	c.1260C>A	c.(1258-1260)cgC>cgA	p.R420R		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	420	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						GGCCCCCACGCCGGGTTGGGA	0.502000													13	47					0.00010058	0.000194774	0.013537	1	0
TMC1	117531	broad.mit.edu	37	9	75387391	75387391	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr9:75387391G>A	ENST00000297784.5	+	13	1344	c.804G>A	c.(802-804)tgG>tgA	p.W268*	TMC1_ENST00000340019.3_Nonsense_Mutation_p.W268*|TMC1_ENST00000396237.3_Nonsense_Mutation_p.W268*	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	268					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						CAATTGGATGGATGAATTTCA	0.398000													7	144					0	0	0.001984	0	0
PHLDB2	90102	broad.mit.edu	37	3	111686558	111686558	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr3:111686558G>A	ENST00000431670.2	+	15	3613	c.3202G>A	c.(3202-3204)Gaa>Aaa	p.E1068K	PHLDB2_ENST00000393923.3_Missense_Mutation_p.E1052K|PHLDB2_ENST00000393925.3_Missense_Mutation_p.E1068K|PHLDB2_ENST00000412622.1_Missense_Mutation_p.E1025K|PHLDB2_ENST00000481953.1_Missense_Mutation_p.E1025K|PHLDB2_ENST00000495180.1_Missense_Mutation_p.E559K	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1068						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						ACGAGCCCTGGAAGAAGAAAA	0.373000											OREG0015707	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	15					0	0	0.000602	0	0
PCLO	27445	broad.mit.edu	37	7	82764796	82764796	+	Silent	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr7:82764796T>C	ENST00000423517.2	-	3	2407	c.2070A>G	c.(2068-2070)ccA>ccG	p.P690P	PCLO_ENST00000333891.8_Silent_p.P690P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	636	Pro-rich.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GATCCTGTTTTGGTGCAGCAT	0.537000													11	36					0	0	0.010729	0	0
RC3H2	54542	broad.mit.edu	37	9	125613379	125613379	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr9:125613379C>G	ENST00000373670.1	-	19	3961	c.3361G>C	c.(3361-3363)Ggt>Cgt	p.G1121R	RC3H2_ENST00000357244.2_Missense_Mutation_p.G1121R			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	1121						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						TGGTCTTCACCTAAACTCTGT	0.383000													23	150					0	0	0.003330	0	0
DLEC1	9940	broad.mit.edu	37	3	38104070	38104070	+	Splice_Site	SNP	A	A	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr3:38104070A>G	ENST00000308059.6	+	5	894		c.e5-1		DLEC1_ENST00000452631.2_Splice_Site|DLEC1_ENST00000346219.3_Splice_Site			Q9Y238	DLEC1_HUMAN	deleted in lung and esophageal cancer 1						negative regulation of cell proliferation	cytoplasm				NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(3)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	51				KIRC - Kidney renal clear cell carcinoma(284;0.0664)|Kidney(284;0.0827)		TATGTTTCAAAGAAAGCAAGT	0.448000													9	30					0	0	0.004482	0	0
ABCG2	9429	broad.mit.edu	37	4	89020602	89020602	+	Splice_Site	SNP	T	T	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr4:89020602T>A	ENST00000237612.3	-	12	1913		c.e12-2		ABCG2_ENST00000515655.1_Splice_Site	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2						cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	TATTCATGTCTATAGAACAAA	0.383000													7	50					0	0	0.001984	0	0
MYO19	80179	broad.mit.edu	37	17	34858967	34858967	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr17:34858967C>A	ENST00000431794.3	-	21	2572	c.2050G>T	c.(2050-2052)Gac>Tac	p.D684Y	MYO19_ENST00000268852.9_Missense_Mutation_p.D484Y	NM_001163735.1	NP_001157207.1	Q96H55	MYO19_HUMAN	myosin XIX	684	Myosin head-like.					mitochondrial outer membrane|myosin complex	actin binding|ATP binding|motor activity			endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|urinary_tract(1)	20		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		TATGGGCTGTCGGGGCCAGAG	0.517000													14	139					0.000219431	0.000405616	0.002450	1	0
KCNA2	3737	broad.mit.edu	37	1	111145958	111145958	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr1:111145958T>C	ENST00000485317.1	-	3	2120	c.1447A>G	c.(1447-1449)Acc>Gcc	p.T483A	KCNA2_ENST00000369770.3_Intron|KCNA2_ENST00000316361.4_Missense_Mutation_p.T483A|KCNA2_ENST00000440270.1_Missense_Mutation_p.T483A			P16389	KCNA2_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 2	483						juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		all_cancers(81;5.55e-06)|all_epithelial(167;1.87e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Colorectal(144;0.00878)|Lung(183;0.0234)|all cancers(265;0.0492)|Epithelial(280;0.0529)|COAD - Colon adenocarcinoma(174;0.131)|LUSC - Lung squamous cell carcinoma(189;0.133)|READ - Rectum adenocarcinoma(129;0.191)		TTAGCCAAGGTACAGTTGGCT	0.383000													22	59					0	0	0.012319	0	0
TRPV5	56302	broad.mit.edu	37	7	142625303	142625303	+	Silent	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr7:142625303C>T	ENST00000265310.1	-	7	1137	c.789G>A	c.(787-789)cgG>cgA	p.R263R	TRPV5_ENST00000442623.1_Silent_p.R263R	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	263					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GGATGTGCCTCCGCTTCTGCA	0.572000													17	90					0	0	0.008871	0	0
GMEB2	26205	broad.mit.edu	37	20	62236177	62236177	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr20:62236177C>G	ENST00000266068.1	-	2	626	c.148G>C	c.(148-150)Gat>Cat	p.D50H	GMEB2_ENST00000370069.1_5'UTR|GMEB2_ENST00000370077.1_Missense_Mutation_p.D50H			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	50					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			TCCATGTTATCTTCCGTCAGG	0.572000													5	98					0	0	0.001168	0	0
PARD3B	117583	broad.mit.edu	37	2	206364756	206364756	+	Splice_Site	SNP	G	G	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr2:206364756G>T	ENST00000406610.2	+	21	3387		c.e21+1		PARD3B_ENST00000358768.2_Splice_Site|PARD3B_ENST00000351153.1_Splice_Site|PARD3B_ENST00000488622.1_Splice_Site|PARD3B_ENST00000349953.3_Splice_Site	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta						cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		CCTACTCTGGGTAAGCGCATG	0.418000													17	86					3.32936e-07	7.00313e-07	0.006122	1	0
RRP36	88745	broad.mit.edu	37	6	42992821	42992821	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr6:42992821C>G	ENST00000244496.5	+	2	239	c.229C>G	c.(229-231)Caa>Gaa	p.Q77E		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	77					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TCCTAAGAAACAAGCTTCTAG	0.443000													5	28					0	0	0.000602	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519925	69519925	+	Silent	SNP	G	G	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr4:69519925G>T	ENST00000338206.5	-	5	1152	c.1143C>A	c.(1141-1143)atC>atA	p.I381I		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	381					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										TCGCCTCATAGATGCCATTGG	0.413000													8	127					1.58986e-06	3.28752e-06	0.008291	1	0
ABCC6	368	broad.mit.edu	37	16	16248520	16248520	+	Silent	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr16:16248520C>T	ENST00000205557.7	-	29	4202	c.4173G>A	c.(4171-4173)ctG>ctA	p.L1391L		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	1391	ABC transporter 2.				response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		ACTTGTACTGCAGCTGGCCGG	0.657000													4	30					0	0	0.000602	0	0
FAM120C	54954	broad.mit.edu	37	X	54107840	54107840	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chrX:54107840C>A	ENST00000375180.2	-	14	2949	c.2893G>T	c.(2893-2895)Gtg>Ttg	p.V965L	FAM120C_ENST00000328235.4_Missense_Mutation_p.L827F	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	965										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CACTGGCCCACAACCATCCCA	0.562000													12	30					0.00136819	0.00249134	0.013537	1	0
CCDC180	100499483	broad.mit.edu	37	9	100105801	100105801	+	Silent	SNP	A	A	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr9:100105801A>G	ENST00000375202.2	+	33	3938	c.2586A>G	c.(2584-2586)gaA>gaG	p.E862E	CCDC180_ENST00000357054.1_Silent_p.E1001E|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000529487.1_Silent_p.E862E|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000460482.2_3'UTR|CCDC180_ENST00000411667.2_Silent_p.E859E					coiled-coil domain containing 180																		AGTTCATAGAACAAGTGACAA	0.373000													8	28					0	0	0.006214	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128902344	128902344	+	Silent	SNP	G	G	A	rs142832297	byFrequency	TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chrX:128902344G>A	ENST00000371106.3	+	21	2100	c.1908G>A	c.(1906-1908)gaG>gaA	p.E636E		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	636					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						AGCTACTAGAGGAGTTCGAGT	0.617000													7	30					0	0	0.006214	0	0
PCSK4	54760	broad.mit.edu	37	19	1488242	1488242	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:1488242A>C	ENST00000300954.5	-	3	393	c.332T>G	c.(331-333)gTg>gGg	p.V111G	PCSK4_ENST00000587784.1_5'UTR	NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	111					proteolysis	integral to membrane	serine-type endopeptidase activity	p.V111G(1)		cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGCGTTTCACCCGCCGCTG	0.682000													4	6					0	0	0.013537	0	0
LINGO2	158038	broad.mit.edu	37	9	27949218	27949218	+	Silent	SNP	G	G	T	rs150860330		TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr9:27949218G>T	ENST00000379992.2	-	6	1901	c.1452C>A	c.(1450-1452)atC>atA	p.I484I	LINGO2_ENST00000308675.3_Silent_p.I484I	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	484	Ig-like C2-type.					integral to membrane		p.I484I(2)		autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		CATTGCTAGCGATGCAAACAT	0.493000													6	37					3.59834e-05	7.0806e-05	0.001168	1	0
LRRC6	23639	broad.mit.edu	37	8	133645019	133645019	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr8:133645019T>C	ENST00000519595.1	-	5	718	c.620A>G	c.(619-621)gAt>gGt	p.D207G	LRRC6_ENST00000518642.1_Missense_Mutation_p.D207G|LRRC6_ENST00000520446.1_Intron|LRRC6_ENST00000250173.1_Missense_Mutation_p.D207G			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	207						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			CCAACGTCCATCAAAGCCTGC	0.373000													15	121					0	0	0.004007	0	0
ZNF711	7552	broad.mit.edu	37	X	84510318	84510318	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chrX:84510318G>C	ENST00000360700.4	+	4	1019	c.133G>C	c.(133-135)Gtt>Ctt	p.V45L	ZNF711_ENST00000395402.1_Missense_Mutation_p.V23L|ZNF711_ENST00000373165.3_Missense_Mutation_p.V45L|ZNF711_ENST00000276123.3_Missense_Mutation_p.V45L			Q9Y462	ZN711_HUMAN	zinc finger protein 711	45					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TGTTGTTTCAGTTCCTGAAGC	0.378000													12	27					0	0	0.001855	0	0
TRMT2A	27037	broad.mit.edu	37	22	20102885	20102885	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr22:20102885T>A	ENST00000252136.7	-	4	1182	c.794A>T	c.(793-795)tAc>tTc	p.Y265F	TRMT2A_ENST00000404751.3_Missense_Mutation_p.Y265F|TRMT2A_ENST00000492988.1_5'UTR|TRMT2A_ENST00000439169.2_Missense_Mutation_p.Y265F|TRMT2A_ENST00000403707.3_Missense_Mutation_p.Y265F	NM_001257994.1|NM_022727.5|NM_182984.4	NP_001244923.1|NP_073564.3|NP_892029.2	Q8IZ69	TRM2A_HUMAN	tRNA methyltransferase 2 homolog A (S. cerevisiae)	265					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(2)|endometrium(2)|lung(5)	9						CCCGCCCTTGTACTTGCCGAG	0.592000													11	51					0	0	0.010729	0	0
DHRS2	10202	broad.mit.edu	37	14	24108035	24108035	+	Splice_Site	SNP	G	G	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr14:24108035G>C	ENST00000250383.6	+	2	438		c.e2-1		DHRS2_ENST00000344777.7_Splice_Site|DHRS2_ENST00000553896.1_Splice_Site	NM_005794.3	NP_005785.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2						C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		CTTTCCCCCAGGCCTGATTCA	0.517000													8	80					0	0	0.004482	0	0
SPERT	220082	broad.mit.edu	37	13	46276977	46276977	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr13:46276977T>C	ENST00000310521.1	+	2	223	c.143T>C	c.(142-144)gTg>gCg	p.V48A		NM_152719.1	NP_689932.1	Q8NA61	SPERT_HUMAN	spermatid associated	48						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CCAATCAGTGTGGTTCTACCT	0.413000													8	27					0	0	0.004482	0	0
RINT1	60561	broad.mit.edu	37	7	105195643	105195643	+	Nonsense_Mutation	SNP	C	C	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr7:105195643C>G	ENST00000257700.2	+	11	1871	c.1640C>G	c.(1639-1641)tCa>tGa	p.S547*		NM_021930.4	NP_068749.3	Q6NUQ1	RINT1_HUMAN	RAD50 interactor 1	547	RINT1/TIP20.				cell cycle|G2/M transition DNA damage checkpoint|protein transport|vesicle-mediated transport	endoplasmic reticulum membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						AACTACATCTCAACAGTACTA	0.323000													4	67					0	0	0.009096	0	0
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:21606712T>C	ENST00000392288.2	+	4	1360	c.1251T>C	c.(1249-1251)tcT>tcC	p.S417S	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.S289S	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						ATAAGGAGTCTTCACACCTTA	0.348000													3	43					0	0	0.004672	0	0
PLEC	5339	broad.mit.edu	37	8	145006974	145006974	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr8:145006974G>A	ENST00000322810.4	-	14	2304	c.2135C>T	c.(2134-2136)gCa>gTa	p.A712V	PLEC_ENST00000398774.2_Missense_Mutation_p.A543V|PLEC_ENST00000345136.3_Missense_Mutation_p.A575V|PLEC_ENST00000527096.1_Missense_Mutation_p.A598V|PLEC_ENST00000354589.3_Missense_Mutation_p.A575V|PLEC_ENST00000356346.3_Missense_Mutation_p.A561V|PLEC_ENST00000354958.2_Missense_Mutation_p.A553V|PLEC_ENST00000436759.2_Missense_Mutation_p.A602V|PLEC_ENST00000357649.2_Missense_Mutation_p.A579V	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	712	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GTCACTCCGTGCCCGCTCGAT	0.692000													6	15					0	0	0.001168	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970715	101970715	+	Silent	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chrX:101970715C>T	ENST00000543253.1	+	5	1837	c.918C>T	c.(916-918)ccC>ccT	p.P306P	GPRASP2_ENST00000535209.1_Silent_p.P306P|GPRASP2_ENST00000332262.5_Silent_p.P306P	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TGTTCAGGCCCAGAGTCAGGG	0.463000													24	61					0	0	0.002780	0	0
PTPRT	11122	broad.mit.edu	37	20	41101003	41101003	+	Silent	SNP	G	G	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr20:41101003G>C	ENST00000373198.3	-	8	1588	c.1353C>G	c.(1351-1353)ggC>ggG	p.G451G	PTPRT_ENST00000356100.2_Silent_p.G451G|PTPRT_ENST00000373190.1_Silent_p.G451G|PTPRT_ENST00000373184.1_Silent_p.G451G|PTPRT_ENST00000373193.3_Silent_p.G451G|PTPRT_ENST00000373187.1_Silent_p.G451G|PTPRT_ENST00000373201.1_Silent_p.G451G	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	451	Fibronectin type-III 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGGGGCGCAGGCCTCGCAGGG	0.602000													4	78					0	0	0.000602	0	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802689	31802689	+	Silent	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr21:31802689C>T	ENST00000334068.2	+	1	118	c.96C>T	c.(94-96)agC>agT	p.S32S		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	32						intermediate filament				NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						TGGTCTACAGCACTGCCCTCT	0.597000													11	92					0	0	0.008291	0	0
CLCN5	1184	broad.mit.edu	37	X	49853490	49853490	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chrX:49853490G>C	ENST00000376088.3	+	12	2334	c.1693G>C	c.(1693-1695)Gat>Cat	p.D565H	CLCN5_ENST00000376108.3_Missense_Mutation_p.D495H|CLCN5_ENST00000376091.3_Missense_Mutation_p.D565H|CLCN5_ENST00000307367.2_Missense_Mutation_p.D495H	NM_001127898.1|NM_001127899.1	NP_001121370.1|NP_001121371.1	P51795	CLCN5_HUMAN	chloride channel, voltage-sensitive 5	495					excretion	apical part of cell|endosome membrane|Golgi membrane|integral to plasma membrane	antiporter activity|ATP binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)	30	Ovarian(276;0.236)					TCAGGGAGCTGATTGCATCAC	0.493000													9	74					0	0	0.008291	0	0
L1CAM	3897	broad.mit.edu	37	X	153134106	153134106	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chrX:153134106C>T	ENST00000370060.1	-	13	1645	c.1456G>A	c.(1456-1458)Gac>Aac	p.D486N	L1CAM_ENST00000370057.3_Missense_Mutation_p.D486N|L1CAM_ENST00000370055.1_Missense_Mutation_p.D481N|L1CAM_ENST00000361981.3_Missense_Mutation_p.D481N|L1CAM_ENST00000538883.1_Missense_Mutation_p.D488N|L1CAM_ENST00000361699.4_Missense_Mutation_p.D486N|L1CAM_ENST00000543994.1_Missense_Mutation_p.D488N	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	486	Ig-like C2-type 5.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCTGGAGGTCTCGAATGCCC	0.572000													9	33					0	0	0.004482	0	0
MYH4	4622	broad.mit.edu	37	17	10366910	10366910	+	Silent	SNP	G	G	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr17:10366910G>A	ENST00000255381.2	-	8	809	c.699C>T	c.(697-699)ttC>ttT	p.F233F	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	233	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.F233F(1)		NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGGCATTGCCGAAGGCTTCCA	0.423000													11	69					0	0	0.013537	0	0
SMOC2	64094	broad.mit.edu	37	6	168910629	168910629	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr6:168910629G>T	ENST00000354536.5	+	2	339	c.119G>T	c.(118-120)tGt>tTt	p.C40F	SMOC2_ENST00000356284.2_Missense_Mutation_p.C40F	NM_022138.2	NP_071421.1	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	40	Kazal-like.				signal transduction	basement membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	32		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		GACAAGGATTGTAGCTTGGAC	0.438000													6	79					0.000157383	0.000295396	0.003080	1	0
GLI3	2737	broad.mit.edu	37	7	42005257	42005257	+	Silent	SNP	G	G	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr7:42005257G>A	ENST00000395925.3	-	15	3498	c.3414C>T	c.(3412-3414)caC>caT	p.H1138H	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1138					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GCTGGCCAGCGTGGCTGTCTG	0.677000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				10	121					0	0	0.006214	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545239	234545239	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr2:234545239A>G	ENST00000344644.5	+	1	140	c.71A>G	c.(70-72)gAg>gGg	p.E24G	UGT1A8_ENST00000373450.4_Intron|UGT1A10_ENST00000373445.1_Missense_Mutation_p.E24G	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GGCTTTGCCGAGGCAGGGAAG	0.592000													16	104					0	0	0.004007	0	0
HOXC11	3227	broad.mit.edu	37	12	54369022	54369022	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr12:54369022T>A	ENST00000546378.1	+	2	856	c.740T>A	c.(739-741)cTg>cAg	p.L247Q	HOXC11_ENST00000243082.4_Silent_p.T248T			O43248	HXC11_HUMAN	homeobox C11	247					endoderm development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)	2						ATCCGGGAACTGGAGCGAGAG	0.567000			T	NUP98	AML								8	47					0	0	0.004482	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			4	17					0	0	0.001168	0	0
ABCC1	4363	broad.mit.edu	37	16	16208863	16208863	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr16:16208863T>C	ENST00000399408.2	+	24	3525	c.3350T>C	c.(3349-3351)gTt>gCt	p.V1117A	ABCC1_ENST00000345148.5_Missense_Mutation_p.V1107A|ABCC1_ENST00000399410.3_Missense_Mutation_p.V1107A|ABCC1_ENST00000349029.5_Missense_Mutation_p.V992A|ABCC1_ENST00000351154.5_Missense_Mutation_p.V1048A|ABCC1_ENST00000346370.5_Missense_Mutation_p.V1051A			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1107	ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GCCTGCATCGTTATCCTGCTG	0.567000													6	45					0	0	0.001984	0	0
PCNX	22990	broad.mit.edu	37	14	71555974	71555974	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr14:71555974T>A	ENST00000304743.2	+	30	5950	c.5504T>A	c.(5503-5505)aTt>aAt	p.I1835N	PCNX_ENST00000439984.3_Missense_Mutation_p.I1724N|PCNX_ENST00000238570.5_Missense_Mutation_p.I1763N	NM_014982.2	NP_055797.2	Q96RV3	PCX1_HUMAN	pecanex homolog (Drosophila)	1835						integral to membrane				NS(2)|biliary_tract(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(14)|liver(2)|lung(40)|ovary(1)|prostate(7)|skin(2)|urinary_tract(1)	87			KIRC - Kidney renal clear cell carcinoma(12;0.206)	all cancers(60;0.00835)|BRCA - Breast invasive adenocarcinoma(234;0.00951)|OV - Ovarian serous cystadenocarcinoma(108;0.0417)		ATTTCTTCAATTCGAGATGAA	0.363000													4	44					0	0	0.009096	0	0
RALGPS2	55103	broad.mit.edu	37	1	178790800	178790800	+	Silent	SNP	A	A	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr1:178790800A>G	ENST00000367635.3	+	7	779	c.441A>G	c.(439-441)ctA>ctG	p.L147L	RALGPS2_ENST00000324778.4_Silent_p.L112L|RALGPS2_ENST00000367634.2_Silent_p.L147L	NM_152663.3	NP_689876.2	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	147	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						TTTCTGGCCTACAGAGTGCCC	0.388000													34	80					0	0	0.004878	0	0
ZNF571	51276	broad.mit.edu	37	19	38056962	38056962	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:38056962G>C	ENST00000328550.2	-	4	467	c.368C>G	c.(367-369)tCa>tGa	p.S123*	ZNF571-AS1_ENST00000586013.1_RNA|ZNF571-AS1_ENST00000592392.1_RNA|ZNF571-AS1_ENST00000589750.1_RNA|ZNF571-AS1_ENST00000587121.1_RNA|ZNF571-AS1_ENST00000591430.1_RNA|ZNF571-AS1_ENST00000589802.1_RNA|ZNF571_ENST00000590751.1_Intron|ZNF571_ENST00000451802.2_Nonsense_Mutation_p.S123*|ZNF571-AS1_ENST00000590838.1_RNA|ZNF571_ENST00000593133.1_Nonsense_Mutation_p.S123*|ZNF571_ENST00000358744.3_Nonsense_Mutation_p.S123*|ZNF571-AS1_ENST00000585578.1_RNA|ZNF540_ENST00000592533.1_Intron|ZNF571-AS1_ENST00000586139.1_RNA			Q7Z3V5	ZN571_HUMAN	zinc finger protein 571	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	25			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGAAGAGGTTGAATGACTTTC	0.403000													9	74					0	0	0.004482	0	0
PRKRA	8575	broad.mit.edu	37	2	179315119	179315119	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr2:179315119C>T	ENST00000325748.4	-	2	285	c.85G>A	c.(85-87)Gct>Act	p.A29T	PRKRA_ENST00000470200.1_5'UTR|PRKRA_ENST00000487082.1_Missense_Mutation_p.A4T|PRKRA_ENST00000438687.3_5'UTR|PRKRA_ENST00000432031.2_Missense_Mutation_p.A18T	NM_003690.4	NP_003681.1	O75569	PRKRA_HUMAN	protein kinase, interferon-inducible double stranded RNA dependent activator	29	Sufficient for self-association and interaction with TARBP2.				immune response|negative regulation of cell proliferation|production of siRNA involved in RNA interference|response to virus	perinuclear region of cytoplasm	double-stranded RNA binding|enzyme activator activity|protein homodimerization activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|skin(2)	19			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.00634)|all cancers(119;0.0265)			CCTGGCTTAGCTGTTATCATC	0.428000													9	173					0	0	0.010729	0	0
LRRC7	57554	broad.mit.edu	37	1	70482195	70482195	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr1:70482195C>A	ENST00000310961.5	+	15	1617	c.1199C>A	c.(1198-1200)gCt>gAt	p.A400D	RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.A395D			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	395						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GAGCTTGCAGCTTTGTGGCTT	0.294000													7	38					0.000157383	0.000295396	0.003080	1	0
BAGE2	85319	broad.mit.edu	37	21	11098920	11098920	+	RNA	SNP	A	A	G	rs78230864		TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr21:11098920A>G	ENST00000470054.1	-	0	5									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gggagataccagagaccctaa	0.572000													3	13					0	0	0.004672	0	0
PTOV1	53635	broad.mit.edu	37	19	50360330	50360330	+	Silent	SNP	C	C	G			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:50360330C>G	ENST00000391842.1	+	6	827	c.657C>G	c.(655-657)ccC>ccG	p.P219P	PTOV1_ENST00000600603.1_Silent_p.P187P|PTOV1_ENST00000221557.9_Silent_p.P187P|PTOV1_ENST00000599732.1_Silent_p.P219P|PTOV1_ENST00000598325.1_3'UTR|AC018766.5_ENST00000593654.1_RNA|PTOV1_ENST00000601675.1_Silent_p.P219P|PTOV1_ENST00000601638.1_Silent_p.P187P	NM_017432.3	NP_059128.2	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	219	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane				endometrium(5)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)	16		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		GCCTCATCCCCTACGACCAGA	0.622000													29	186					0	0	0.008361	0	0
CD109	135228	broad.mit.edu	37	6	74521963	74521963	+	Silent	SNP	C	C	G	rs144445787		TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr6:74521963C>G	ENST00000437994.2	+	29	4118	c.3687C>G	c.(3685-3687)tcC>tcG	p.S1229S	CD109_ENST00000422508.2_Silent_p.S1169S|CD109_ENST00000287097.5_Silent_p.S1246S	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	1246						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTAATATTTCCGCAAATGGTT	0.333000													5	53					0	0	0.001168	0	0
CSPG4	1464	broad.mit.edu	37	15	75982728	75982728	+	Silent	SNP	T	T	C			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr15:75982728T>C	ENST00000308508.5	-	3	770	c.678A>G	c.(676-678)ctA>ctG	p.L226L		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	226	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 2.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GTGTAAACTCTAGGGTTCCTT	0.607000													3	51					0	0	0.004672	0	0
BOD1L1	259282	broad.mit.edu	37	4	13582680	13582681	+	Splice_Site	INS	-	-	A			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr4:13582680_13582681insA	ENST00000040738.5	-	21	8804		c.e21-2			NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1								DNA binding										AGTCGTCTTCTAAAAAAAAAAA	0.337													2	4	---	---	---	---					
CCT6P3	643180	broad.mit.edu	37	7	64528813	64528814	+	RNA	INS	-	-	T			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr7:64528813_64528814insT	ENST00000426828.1	+	0	621					NR_033416.1																						CTTTCTGTAACTTTTTTTTTTT	0.317													3	6	---	---	---	---					
FAM66B	100128890	broad.mit.edu	37	8	7196263	7196264	+	RNA	DEL	AC	AC	-			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr8:7196263_7196264delAC	ENST00000606573.1	-	0	703																											ACTGAGGGGTacacacacacac	0.500													2	4	---	---	---	---					
KCNG2	26251	broad.mit.edu	37	18	77623691	77623692	+	In_Frame_Ins	INS	-	-	GGC	rs71338073		TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr18:77623691_77623692insGGC	ENST00000316249.3	+	1	24_25	c.24_25insGGC	c.(22-27)ccgcgg>ccGGCgcgg	p.8_9PR>PAR		NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	8					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity	p.P8_G9insG(2)		breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CCTGCTccccgggcggcggcgg	0.772													3	3	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1207065	1207065	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:1207065delG	ENST00000326873.7	+	1	1326	c.153delG	c.(151-153)atfs	p.M51fs	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	51	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.D53fs*11(1)|p.L50_D53del(1)|p.M51fs*14(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTACCTGATGGGGGACCTGC	0.607		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			7	40	---	---	---	---					
LMTK3	114783	broad.mit.edu	37	19	49001784	49001784	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7160-01A-11D-2036-08	TCGA-78-7160-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b484b2dd-a2e1-430c-bbb4-61ac5db5d1e9	37732c62-0d8b-4ba4-a832-55cd5d0f6d49	g.chr19:49001784delG	ENST00000600059.1	-	11	2769	c.2542delC	c.(2542-2544)ggfs	p.R848fs	LMTK3_ENST00000270238.3_Frame_Shift_Del_p.R877fs					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGCTTCTCCCGGGGCCCCGGG	0.716													2	4	---	---	---	---