Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AFTPH	54812	broad.mit.edu	37	2	64796266	64796266	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:64796266G>A	ENST00000422803.1	+	4	2442	c.2128G>A	c.(2128-2130)Gat>Aat	p.D710N	AFTPH_ENST00000238856.4_Missense_Mutation_p.D710N|AFTPH_ENST00000487769.1_Intron|AFTPH_ENST00000409933.1_Missense_Mutation_p.D710N|AFTPH_ENST00000238855.7_Missense_Mutation_p.D710N|AFTPH_ENST00000409183.1_Missense_Mutation_p.D341N			Q6ULP2	AFTIN_HUMAN	aftiphilin	710					protein transport	AP-1 adaptor complex|cytosol|nucleus	clathrin binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	35						GGATATCCATGATGCACATGG	0.458000													70	96					0	0	1	0	0
NTM	50863	broad.mit.edu	37	11	132082041	132082041	+	Splice_Site	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:132082041G>T	ENST00000374786.1	+	3	1005	c.526_splice	c.e3+1	p.A176_splice	NTM_ENST00000374791.3_Splice_Site_p.A176_splice|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000539799.1_Splice_Site_p.A176_splice|NTM_ENST00000425719.2_Splice_Site_p.A176_splice|NTM_ENST00000374784.1_Splice_Site_p.A176_splice|NTM_ENST00000427481.2_Splice_Site_p.A167_splice	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	176	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						CTCTCCCAAAGGTAAGAGAAC	0.453000													11	163					0.00010058	0.000104247	1	1	0
SLC18A2	6571	broad.mit.edu	37	10	119015131	119015131	+	Silent	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:119015131C>G	ENST00000298472.5	+	9	1001	c.858C>G	c.(856-858)acC>acG	p.T286T	SLC18A2_ENST00000497497.1_3'UTR	NM_003054.4	NP_003045.2	Q05940	VMAT2_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 2	286					neurotransmitter secretion	clathrin sculpted monoamine transport vesicle membrane|integral to plasma membrane|membrane fraction	monoamine transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)	29		Colorectal(252;0.19)		all cancers(201;0.029)	Alseroxylon(DB00386)|Reserpine(DB00206)|Tetrabenazine(DB04844)	CACCCCTAACCACGCTGCTGA	0.607000													15	8					0	0	1	0	0
SNTA1	6640	broad.mit.edu	37	20	31996554	31996554	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:31996554C>T	ENST00000217381.2	-	7	1649	c.1378G>A	c.(1378-1380)Ggt>Agt	p.G460S		NM_003098.2	NP_003089.1	Q13424	SNTA1_HUMAN	syntrophin, alpha 1	460	SU.				muscle contraction	cell junction|cytoplasm|cytoskeleton|sarcolemma	actin binding|calmodulin binding			breast(1)|large_intestine(4)|liver(1)|lung(4)|skin(1)|stomach(1)|urinary_tract(1)	13						AGACTGGCACCGTCATCTGAA	0.617000													81	49					0	0	1	0	0
GDPD4	220032	broad.mit.edu	37	11	76956338	76956338	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:76956338G>A	ENST00000315938.4	-	11	1324	c.1074C>T	c.(1072-1074)atC>atT	p.I358I	GDPD4_ENST00000376217.2_Silent_p.I358I	NM_182833.1	NP_878253.1	Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	358	GDPD.				glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						GATGTTGCTCGATTTTAGAGG	0.438000													25	245					0	0	1	0	0
HFM1	164045	broad.mit.edu	37	1	91779021	91779021	+	Silent	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:91779021G>C	ENST00000370425.3	-	30	3374	c.3276C>G	c.(3274-3276)gtC>gtG	p.V1092V	HFM1_ENST00000462405.1_5'UTR|HFM1_ENST00000294696.5_Silent_p.V324V|HFM1_ENST00000370424.3_Silent_p.V771V	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)	1092	SEC63.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CTAAGTAAAAGACTGTAAGTT	0.308000													6	43					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831420	49831420	+	RNA	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:49831420T>A	ENST00000527477.1	+	0	1645																											ACAAGTTTTCTTGCATGGGGT	0.463000													24	37					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100226913	100226913	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:100226913T>A	ENST00000524871.1	+	25	3555	c.3265T>A	c.(3265-3267)Ttg>Atg	p.L1089M	CNTN5_ENST00000528682.1_Missense_Mutation_p.L1089M|CNTN5_ENST00000418526.2_Missense_Mutation_p.L1015M|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Missense_Mutation_p.L1089M	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1089					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ATCAGTCACCTTGCTCTTGGC	0.413000													6	55					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27238520	27238520	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:27238520C>T	ENST00000254227.3	-	2	615	c.590G>A	c.(589-591)tGg>tAg	p.W197*		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	197	Ligand-binding (By similarity).				cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		ACACAGCACCCAGTGAGCCTC	0.652000													17	29					0	0	1	0	0
GOLGA4	2803	broad.mit.edu	37	3	37366433	37366433	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:37366433C>T	ENST00000361924.2	+	14	3430	c.3056C>T	c.(3055-3057)tCa>tTa	p.S1019L	GOLGA4_ENST00000356847.4_Missense_Mutation_p.S1041L|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1019	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						GATGCAGTGTCAAGACTGGAA	0.378000													47	12					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38352385	38352385	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:38352385C>T	ENST00000322350.5	+	5	843	c.497C>T	c.(496-498)gCg>gTg	p.A166V	EGFLAM_ENST00000354891.3_Missense_Mutation_p.A166V	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	166	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					AAACCTGGAGCGAGTGAAGGA	0.527000													81	133					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108051465	108051465	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:108051465C>T	ENST00000280758.5	+	17	3813	c.3285C>T	c.(3283-3285)caC>caT	p.H1095H	BTBD11_ENST00000357167.4_Silent_p.H632H|BTBD11_ENST00000420571.2_Silent_p.H976H|BTBD11_ENST00000494235.2_Silent_p.H174H	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	1095						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						AGTCCATCCACTTGTCGTCTT	0.512000													12	76					0	0	1	0	0
SLC25A45	283130	broad.mit.edu	37	11	65147341	65147341	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:65147341C>T	ENST00000417511.2	-	7	1158	c.24G>A	c.(22-24)gaG>gaA	p.E8E	SLC25A45_ENST00000534028.1_Intron|SLC25A45_ENST00000526432.1_Silent_p.E50E|SLC25A45_ENST00000360662.3_Intron|SLC25A45_ENST00000398802.1_Silent_p.E50E|SLC25A45_ENST00000294187.6_Silent_p.E8E|SLC25A45_ENST00000527174.1_Silent_p.E50E|SLC25A45_ENST00000377152.2_Silent_p.E8E	NM_001278251.1	NP_001265180.1	Q8N413	S2545_HUMAN	solute carrier family 25, member 45	50					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	14						CACTCACGGACTCATGGCGGT	0.617000													9	46					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221057558	221057558	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:221057558C>A	ENST00000366903.6	+	4	2480	c.979C>A	c.(979-981)Cgg>Agg	p.R327R	HLX_ENST00000549319.1_Silent_p.R113R	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	327					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		GTTCCAGAACCGGCGGATGAA	0.637000													37	8					6.21074e-16	7.5133e-16	1	1	0
FAM127B	26071	broad.mit.edu	37	X	134186112	134186112	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:134186112C>T	ENST00000370775.2	-	1	93	c.27G>A	c.(25-27)aaG>aaA	p.K9K	FAM127B_ENST00000520964.1_5'UTR	NM_001078172.1	NP_001071640.1	Q9BWD3	F127B_HUMAN	family with sequence similarity 127, member B	9										breast(3)|endometrium(2)|large_intestine(3)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;0.000127)					CCAGGAGGGCCTTCATCAGCT	0.701000													9	91					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155448853	155448853	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:155448853G>C	ENST00000368346.3	-	3	4447	c.3808C>G	c.(3808-3810)Cga>Gga	p.R1270G	ASH1L_ENST00000392403.3_Missense_Mutation_p.R1270G			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1270					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTCCGTTTTCGTTTCTGCCTT	0.393000													65	144					0	0	1	0	0
TSPEAR	54084	broad.mit.edu	37	21	45987698	45987698	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr21:45987698T>A	ENST00000323084.4	-	2	339	c.274A>T	c.(274-276)Act>Tct	p.T92S	TSPEAR_ENST00000397916.1_Missense_Mutation_p.T24S	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	92	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						ACTCTCAAAGTTACGACGATG	0.507000													6	53					0	0	1	0	0
CCDC51	79714	broad.mit.edu	37	3	48476460	48476460	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:48476460C>A	ENST00000395694.2	-	2	164	c.79G>T	c.(79-81)Gga>Tga	p.G27*	CCDC51_ENST00000395696.1_Nonsense_Mutation_p.G27*|CCDC51_ENST00000447018.1_Intron|CCDC51_ENST00000412398.2_Intron|CCDC51_ENST00000442740.1_Intron	NM_001256964.1	NP_001243893.1	Q96ER9	CCD51_HUMAN	coiled-coil domain containing 51	27						integral to membrane				endometrium(4)|kidney(4)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		AGGTCCCTTCCAAGGAGGCCC	0.647000													19	6					7.33628e-21	9.38855e-21	1	1	0
ZC3H13	23091	broad.mit.edu	37	13	46619597	46619597	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:46619597T>C	ENST00000242848.4	-	2	394	c.46A>G	c.(46-48)Ata>Gta	p.I16V	ZC3H13_ENST00000282007.3_Missense_Mutation_p.I16V			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	16							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		CTATCAGATATAGTCTTGGTA	0.418000													80	34					0	0	1	0	0
ORC5	5001	broad.mit.edu	37	7	103808967	103808967	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:103808967C>T	ENST00000545943.1	-	10	1060	c.435G>A	c.(433-435)caG>caA	p.Q145Q	ORC5_ENST00000447452.2_Silent_p.Q277Q|ORC5_ENST00000297431.4_Silent_p.Q277Q			O43913	ORC5_HUMAN	origin recognition complex, subunit 5	277					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding			kidney(1)|large_intestine(2)|lung(9)|pancreas(1)|upper_aerodigestive_tract(1)	14						GCTTTTCCCACTGGGAACTGA	0.333000													53	94					0	0	1	0	0
SLC9A8	23315	broad.mit.edu	37	20	48503372	48503372	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:48503372G>C	ENST00000417961.1	+	15	1833	c.1623G>C	c.(1621-1623)aaG>aaC	p.K541N	SLC9A8_ENST00000361573.2_Missense_Mutation_p.K525N|SLC9A8_ENST00000490250.1_3'UTR|SLC9A8_ENST00000541138.1_Missense_Mutation_p.K225N|SLC9A8_ENST00000539601.1_Missense_Mutation_p.K306N	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	525						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			AGGACCTTAAGGGCTTCGTGT	0.627000													26	92					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88300969	88300969	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:88300969C>A	ENST00000418177.2	-	8	2249	c.1882G>T	c.(1882-1884)Ggc>Tgc	p.G628C	GRM5_ENST00000455756.2_Missense_Mutation_p.G628C|GRM5_ENST00000305432.5_Missense_Mutation_p.G628C|GRM5_ENST00000393297.1_Missense_Mutation_p.G628C|GRM5_ENST00000305447.4_Missense_Mutation_p.G628C			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	628					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CATAAGTAGCCCAGGCAGATG	0.478000													16	76					1.22574e-08	1.32566e-08	1	1	0
ADCY8	114	broad.mit.edu	37	8	131916041	131916041	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:131916041C>A	ENST00000286355.5	-	7	3980	c.1888G>T	c.(1888-1890)Gat>Tat	p.D630Y	ADCY8_ENST00000377928.3_Missense_Mutation_p.D630Y	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	630					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			ACGATATTATCAAAGGGCAGT	0.507000										HNSCC(32;0.087)			76	17					9.24773e-40	1.32396e-39	1	1	0
DHX34	9704	broad.mit.edu	37	19	47876148	47876148	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:47876148A>T	ENST00000328771.4	+	8	2279	c.1930A>T	c.(1930-1932)Acg>Tcg	p.T644S		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	644						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TGACCCCTTCACGCTCTTCAA	0.682000													22	2					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61823326	61823326	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:61823326C>A	ENST00000577390.1	-	8	2292	c.1338G>T	c.(1336-1338)ggG>ggT	p.G446G	CDH8_ENST00000577730.1_Silent_p.G446G|CDH8_ENST00000299345.6_Silent_p.G446G|CDH8_ENST00000584337.1_Silent_p.G446G	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	446	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GCGTTATCTTCCCATCGTCTG	0.403000													18	58					2.4624e-09	2.69982e-09	1	1	0
KCNA5	3741	broad.mit.edu	37	12	5154975	5154975	+	Silent	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:5154975G>C	ENST00000252321.3	+	1	1891	c.1662G>C	c.(1660-1662)cgG>cgC	p.R554R		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	554						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GAGTCCAGCGGAAGGTCAGCG	0.637000													34	13					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2969697	2969697	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:2969697C>T	ENST00000396946.4	-	12	1985	c.1582G>A	c.(1582-1584)Gag>Aag	p.E528K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	528					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity	p.E521K(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CCTTCTTCCTCGTGCCCCTTG	0.617000			Mis		DLBCL								20	72					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128492926	128492926	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:128492926G>T	ENST00000325888.8	+	37	6310	c.6049G>T	c.(6049-6051)Gtg>Ttg	p.V2017L	RP11-309L24.2_ENST00000469965.1_RNA|FLNC_ENST00000346177.6_Missense_Mutation_p.V1984L	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	2017					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						CGTGGTGAGCGTGCGCAAGAG	0.642000													33	65					6.50621e-10	7.19298e-10	1	1	0
GRB10	2887	broad.mit.edu	37	7	50680527	50680527	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:50680527C>A	ENST00000403097.1	-	12	1867	c.1087G>T	c.(1087-1089)Gtc>Ttc	p.V363F	GRB10_ENST00000406641.1_Missense_Mutation_p.V311F|GRB10_ENST00000335866.3_Missense_Mutation_p.V311F|GRB10_ENST00000407526.1_Missense_Mutation_p.V311F|GRB10_ENST00000398812.2_Missense_Mutation_p.V369F|GRB10_ENST00000398810.2_Missense_Mutation_p.V311F|GRB10_ENST00000357271.5_Missense_Mutation_p.V323F|GRB10_ENST00000402497.1_Missense_Mutation_p.V311F|GRB10_ENST00000401949.1_Missense_Mutation_p.V369F|GRB10_ENST00000439599.1_Missense_Mutation_p.V363F|GRB10_ENST00000402578.1_Missense_Mutation_p.V311F			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	369	PH.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					TCATTCCTGACTTTGTTTGGC	0.483000									Russell-Silver syndrome				12	23					2.27111e-07	2.42333e-07	1	1	0
RBBP9	10741	broad.mit.edu	37	20	18470627	18470627	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:18470627G>A	ENST00000337227.4	-	5	417	c.342C>T	c.(340-342)ttC>ttT	p.F114F	RBBP9_ENST00000493184.1_5'UTR	NM_006606.2	NP_006597.2	O75884	RBBP9_HUMAN	retinoblastoma binding protein 9	114						cytoplasm|nucleus	hydrolase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|prostate(1)	9						AGGGGCGGGTGAAGTATCCTA	0.478000													5	9					0	0	1	0	0
PPP1R21	129285	broad.mit.edu	37	2	48687257	48687257	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:48687257G>T	ENST00000294952.8	+	6	721	c.564G>T	c.(562-564)aaG>aaT	p.K188N	PPP1R21_ENST00000449090.2_Missense_Mutation_p.K188N|PPP1R21_ENST00000281394.4_Missense_Mutation_p.K188N	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21	188										endometrium(2)|kidney(4)|lung(9)	15						CTCTAGAAAAGGAAGCCAAGG	0.443000													11	30					3.35478e-16	4.09571e-16	1	1	0
DCC	1630	broad.mit.edu	37	18	50918122	50918122	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr18:50918122G>T	ENST00000442544.2	+	17	3169	c.2553G>T	c.(2551-2553)caG>caT	p.Q851H	DCC_ENST00000412726.1_Missense_Mutation_p.Q679H|DCC_ENST00000581580.1_Missense_Mutation_p.Q486H	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	851	Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TAGGTGTACAGGCTGTGGCTC	0.537000													89	136					1.47424e-42	2.15716e-42	1	1	0
GPLD1	2822	broad.mit.edu	37	6	24448417	24448417	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:24448417A>T	ENST00000230036.1	-	16	1576	c.1466T>A	c.(1465-1467)tTt>tAt	p.F489Y		NM_001503.3	NP_001494.2	P80108	PHLD_HUMAN	glycosylphosphatidylinositol specific phospholipase D1	489						extracellular region	glycosylphosphatidylinositol phospholipase D activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(11)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	32						TTTGGAACCAAAGTAGACATA	0.443000													19	18					0	0	1	0	0
CPA4	51200	broad.mit.edu	37	7	129950788	129950788	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:129950788G>T	ENST00000222482.4	+	9	983	c.955G>T	c.(955-957)Ggg>Tgg	p.G319W	CPA4_ENST00000493259.1_Missense_Mutation_p.G215W|CPA4_ENST00000445470.2_Missense_Mutation_p.G286W	NM_016352.3	NP_057436.2	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4	319					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Melanoma(18;0.0435)					GTATCCATATGGGTACTCAGT	0.552000													81	126					4.10057e-40	5.8918e-40	1	1	0
CYP4F2	8529	broad.mit.edu	37	19	16000319	16000319	+	Missense_Mutation	SNP	G	G	T	rs4605294		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:16000319G>T	ENST00000221700.5	-	7	927	c.832C>A	c.(832-834)Ctc>Atc	p.L278I	CYP4F2_ENST00000592328.1_Missense_Mutation_p.L278I|CYP4F2_ENST00000011989.7_Missense_Mutation_p.L129I	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	278					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TGGCTAGGGAGAGTGCGGCGC	0.582000													47	16					1.39843e-22	1.83084e-22	1	1	0
PRRC2A	7916	broad.mit.edu	37	6	31597368	31597368	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:31597368A>G	ENST00000376033.2	+	14	2234	c.2000A>G	c.(1999-2001)cAt>cGt	p.H667R	PRRC2A_ENST00000376007.4_Missense_Mutation_p.H667R	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	667	4 X 57 AA type A repeats.|Poly-Gln.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						tggcagcagcatcaacagGGC	0.622000													12	44					0	0	1	0	0
SMCHD1	23347	broad.mit.edu	37	18	2740725	2740725	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr18:2740725G>A	ENST00000320876.6	+	28	3877	c.3539G>A	c.(3538-3540)gGa>gAa	p.G1180E	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Missense_Mutation_p.G1180E	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1180					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						GATCAGTACGGAAATCAGATT	0.294000													37	48					0	0	1	0	0
NXPE4	54827	broad.mit.edu	37	11	114442043	114442043	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:114442043G>T	ENST00000375478.3	-	6	1432	c.1252C>A	c.(1252-1254)Cgg>Agg	p.R418R	NXPE4_ENST00000424261.2_Silent_p.R134R	NM_001077639.1	NP_001071107.1			neurexophilin and PC-esterase domain family, member 4																		TCAATGGCCCGGGTGAGGTAC	0.428000													245	122					1.75489e-134	2.69671e-134	1	1	0
DNAJC6	9829	broad.mit.edu	37	1	65874376	65874376	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:65874376C>T	ENST00000395325.3	+	17	2530	c.2373C>T	c.(2371-2373)ttC>ttT	p.F791F	DNAJC6_ENST00000371069.4_Silent_p.F848F|DNAJC6_ENST00000263441.7_Silent_p.F778F	NM_014787.3	NP_055602.1	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	791					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(22)|ovary(1)|prostate(2)|skin(1)	39						GTCAAGGTTTCAATGCTCACA	0.383000													20	35					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38747797	38747797	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:38747797C>A	ENST00000359357.3	+	13	1698	c.1444C>A	c.(1444-1446)Cgt>Agt	p.R482S	DNAH8_ENST00000441566.1_Missense_Mutation_p.R482S|DNAH8_ENST00000449981.2_Missense_Mutation_p.R699S					dynein, axonemal, heavy chain 8									p.R482C(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CACAATAGAGCGTATTCTTCA	0.323000													31	26					6.97489e-18	8.62113e-18	1	1	0
ANKRD50	57182	broad.mit.edu	37	4	125591421	125591421	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:125591421T>A	ENST00000504087.1	-	4	4048	c.3011A>T	c.(3010-3012)gAc>gTc	p.D1004V	ANKRD50_ENST00000515641.1_Missense_Mutation_p.D825V	NM_020337.2	NP_065070.1	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1004										NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(14)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	55						AGCATTGACGTCAGCATGGTA	0.493000													24	46					0	0	1	0	0
PROSER1	80209	broad.mit.edu	37	13	39586309	39586309	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:39586309C>A	ENST00000352251.3	-	12	3456	c.2623G>T	c.(2623-2625)Ggt>Tgt	p.G875C	PROSER1_ENST00000484434.2_5'UTR|PROSER1_ENST00000350125.3_Missense_Mutation_p.G853C	NM_025138.3	NP_079414.3	Q86XN7	CM023_HUMAN	proline and serine rich 1	875																	CCAGGGATACCCGGGAGGGAC	0.448000													89	60					1.51934e-53	2.2733e-53	1	1	0
MGAT4C	25834	broad.mit.edu	37	12	86383241	86383241	+	Silent	SNP	G	G	A	rs138787902	by1000genomes	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:86383241G>A	ENST00000604798.1	-	6	1288	c.84C>T	c.(82-84)ttC>ttT	p.F28F	MGAT4C_ENST00000548651.1_Silent_p.F28F|MGAT4C_ENST00000332156.1_Silent_p.F28F|MGAT4C_ENST00000393205.2_Silent_p.F57F|MGAT4C_ENST00000552435.2_Silent_p.F28F|MGAT4C_ENST00000549405.2_Silent_p.F28F|MGAT4C_ENST00000552808.2_Silent_p.F28F			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	28					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						GAACTCCCAAGAATGACACTG	0.313000													18	13					0	0	1	0	0
SMARCD2	6603	broad.mit.edu	37	17	61911586	61911586	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:61911586T>G	ENST00000448276.2	-	8	1289	c.1024A>C	c.(1024-1026)Aac>Cac	p.N342H	SMARCD2_ENST00000225742.9_Missense_Mutation_p.N267H|SMARCD2_ENST00000323347.10_Missense_Mutation_p.N294H	NM_001098426.1	NP_001091896.1	Q92925	SMRD2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	342	SWIB.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	SWI/SNF complex	protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)	8						TGCAGCTGGTTGTGCTTGATG	0.587000											OREG0024642	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	16					0	0	1	0	0
AOAH	313	broad.mit.edu	37	7	36579941	36579941	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:36579941G>T	ENST00000431169.1	-	16	1590	c.1290C>A	c.(1288-1290)aaC>aaA	p.N430K	AOAH_ENST00000491444.1_5'UTR|AOAH_ENST00000538464.1_Missense_Mutation_p.N152K|AOAH_ENST00000258749.5_Missense_Mutation_p.N430K|AOAH_ENST00000535891.1_Missense_Mutation_p.N398K	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	430					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						GATGATATCTGTTGTGCAAAT	0.363000													11	24					7.93312e-07	8.4422e-07	1	1	0
STAB2	55576	broad.mit.edu	37	12	103988209	103988209	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:103988209C>T	ENST00000388887.2	+	3	456	c.252C>T	c.(250-252)ctC>ctT	p.L84L		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	84					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CTCTGTCTCTCCCCGGATGCC	0.507000													101	90					0	0	1	0	0
PRPH2	5961	broad.mit.edu	37	6	42690066	42690066	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:42690066G>A	ENST00000230381.5	-	1	246	c.7C>T	c.(7-9)Cta>Tta	p.L3L		NM_000322.4	NP_000313.2	P23942	PRPH2_HUMAN	peripherin 2 (retinal degeneration, slow)	3					cell adhesion|visual perception	integral to membrane				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	18	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.00178)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0904)			ACTTTCAGTAGCGCCATGCTT	0.552000													4	39					0	0	1	0	0
NUP214	8021	broad.mit.edu	37	9	134015982	134015982	+	Silent	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr9:134015982A>T	ENST00000359428.5	+	11	1323	c.1179A>T	c.(1177-1179)tcA>tcT	p.S393S	RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000589540.1_RNA|NUP214_ENST00000411637.2_Silent_p.S393S|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|NUP214_ENST00000451030.1_Silent_p.S393S|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000588378.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	393					carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGTTACTTTCAACAGATGGTG	0.378000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								58	19					0	0	1	0	0
CRY2	1408	broad.mit.edu	37	11	45891234	45891234	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:45891234A>G	ENST00000443527.2	+	7	1145	c.1123A>G	c.(1123-1125)Aca>Gca	p.T375A	CRY2_ENST00000417225.2_Missense_Mutation_p.T293A	NM_021117.3	NP_066940.2	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like)	354	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						TGAGGGCAAGACAGGCTTCCC	0.637000													69	97					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117053313	117053313	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:117053313G>T	ENST00000368564.1	+	14	1595	c.1447G>T	c.(1447-1449)Gag>Tag	p.E483*	KPNA5_ENST00000356348.1_Nonsense_Mutation_p.E483*			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	480					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		GGATAAAATTGAGTTTTTGCA	0.269000													18	13					3.51602e-12	3.98682e-12	1	1	0
MAGEL2	54551	broad.mit.edu	37	15	23889220	23889220	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:23889220C>A	ENST00000532292.1	-	1	1955	c.1861G>T	c.(1861-1863)Gag>Tag	p.E621*		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TCTTCCCACTCACACTCTGCG	0.557000													15	32					6.72482e-11	7.5182e-11	1	1	0
NFATC2	4773	broad.mit.edu	37	20	50048864	50048864	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:50048864C>A	ENST00000371564.3	-	9	2681	c.2462G>T	c.(2461-2463)cGc>cTc	p.R821L	NFATC2_ENST00000414705.1_Missense_Mutation_p.R801L|NFATC2_ENST00000396009.3_Missense_Mutation_p.R821L	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	821					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GCTTCCGCAGCGCAGCTGCTG	0.652000													143	58					7.43762e-64	1.12554e-63	1	1	0
DGKB	1607	broad.mit.edu	37	7	14775705	14775705	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:14775705T>C	ENST00000403951.2	-	5	702	c.283A>G	c.(283-285)Agt>Ggt	p.S95G	DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000406247.3_Missense_Mutation_p.S95G|DGKB_ENST00000402815.1_Missense_Mutation_p.S95G|DGKB_ENST00000444700.2_Missense_Mutation_p.S88G|DGKB_ENST00000407950.1_Missense_Mutation_p.S88G|DGKB_ENST00000258767.5_Missense_Mutation_p.S95G|DGKB_ENST00000399322.3_Missense_Mutation_p.S95G			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	95					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	ACCATTGGACTAGAATGAGGA	0.353000													7	11					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17697569	17697569	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:17697569C>G	ENST00000353383.1	+	3	1776	c.1307C>G	c.(1306-1308)aCg>aGg	p.T436R	RAI1_ENST00000261641.6_Missense_Mutation_p.T436R	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	436						cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		CAGAGCCTCACGGCGCTGACC	0.602000													35	20					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092249	30092249	+	RNA	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr18:30092249C>A	ENST00000567636.1	+	0	624					NR_003558.1																						ATGCCACATGCTTCTTCTAAC	0.473000													7	9					0.00198382	0.00202972	1	1	0
DGKG	1608	broad.mit.edu	37	3	185882739	185882739	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:185882739C>A	ENST00000265022.3	-	23	2703	c.2164G>T	c.(2164-2166)Ggc>Tgc	p.G722C	DGKG_ENST00000447054.1_5'UTR|DGKG_ENST00000544847.1_Missense_Mutation_p.G663C|DGKG_ENST00000344484.4_Missense_Mutation_p.G697C|DGKG_ENST00000382164.4_Missense_Mutation_p.G683C	NM_001080744.1|NM_001080745.1|NM_001346.2	NP_001074213.1|NP_001074214.1|NP_001337.2	P49619	DGKG_HUMAN	diacylglycerol kinase, gamma 90kDa	722					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CTCTTCAGGCCGGTGTAGATC	0.587000													40	42					3.76604e-16	4.58374e-16	1	1	0
WDR3	10885	broad.mit.edu	37	1	118495150	118495150	+	Splice_Site	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:118495150G>T	ENST00000349139.4	+	19	2063		c.e19-1			NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3							nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		TTCTCCTCCAGGGTCATCACC	0.383000													21	33					2.21704e-12	2.52109e-12	1	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33637845	33637845	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:33637845C>T	ENST00000504830.1	-	12	2060	c.1725G>A	c.(1723-1725)aaG>aaA	p.K575K	ADAMTS12_ENST00000352040.3_Silent_p.K575K|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	575	TSP type-1 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						TCCCTCCAAACTTTGGCCTGC	0.463000										HNSCC(64;0.19)			18	25					0	0	1	0	0
EGR1	1958	broad.mit.edu	37	5	137803189	137803189	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:137803189C>T	ENST00000239938.4	+	2	1323	c.1051C>T	c.(1051-1053)Cgc>Tgc	p.R351C		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	351					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CCGCTTCTCCCGCTCCGACGA	0.662000													44	21					0	0	1	0	0
EFHC1	114327	broad.mit.edu	37	6	52334218	52334218	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:52334218G>T	ENST00000371068.5	+	7	1328	c.1225G>T	c.(1225-1227)Gtt>Ttt	p.V409F	EFHC1_ENST00000433625.2_Missense_Mutation_p.V318F|EFHC1_ENST00000538167.1_Missense_Mutation_p.V390F	NM_018100.3	NP_060570.2	Q5JVL4	EFHC1_HUMAN	EF-hand domain (C-terminal) containing 1	409						axoneme|neuronal cell body	calcium ion binding|protein C-terminus binding			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(8)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	27	Lung NSC(77;0.109)					AAAAAAAGACGTTATTAAAAT	0.368000													44	34					3.21987e-24	4.2575e-24	1	1	0
MYH6	4624	broad.mit.edu	37	14	23866453	23866453	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:23866453T>A	ENST00000405093.3	-	17	2046	c.1976A>T	c.(1975-1977)aAg>aTg	p.K659M	MYH6_ENST00000356287.3_Missense_Mutation_p.K659M	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	659	Actin-binding.|Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GGTCATTAGCTTGTTGAGATT	0.547000													73	155					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61468500	61468500	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:61468500G>T	ENST00000343916.3	+	30	1672	c.1669G>T	c.(1669-1671)Ggt>Tgt	p.G557C	COL9A3_ENST00000462700.1_3'UTR	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	557	Triple-helical region 2 (COL2).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					TGGTCGGCCCGGTCCAGCTGG	0.652000													176	78					7.61791e-68	1.15722e-67	1	1	0
IGKV2D-29	28882	broad.mit.edu	37	2	89986811	89986811	+	RNA	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:89986811T>C	ENST00000491977.1	+	0	122																											CCACTCTCTCTGTCCGTCACC	0.473000													37	35					0	0	1	0	0
POU2AF1	5450	broad.mit.edu	37	11	111225223	111225223	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:111225223C>T	ENST00000393067.3	-	5	1048	c.534G>A	c.(532-534)ccG>ccA	p.P178P		NM_006235.2	NP_006226.2	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	178					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|kidney(2)|lung(2)	5		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		GCTGAGGCCACGGGAAATAGG	0.652000			T	BCL6	NHL								15	38					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62818422	62818422	+	RNA	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:62818422C>A	ENST00000582986.1	-	0	277					NR_024386.1																						CTCCATCAGGCCATTGTTCAG	0.627000													20	33					3.10358e-05	3.25059e-05	1	1	0
NRCAM	4897	broad.mit.edu	37	7	107864242	107864242	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:107864242G>T	ENST00000379028.3	-	11	1287	c.817C>A	c.(817-819)Cca>Aca	p.P273T	NRCAM_ENST00000379024.4_Missense_Mutation_p.P254T|NRCAM_ENST00000425651.2_Missense_Mutation_p.P273T|NRCAM_ENST00000379022.4_Missense_Mutation_p.P273T|NRCAM_ENST00000351718.4_Missense_Mutation_p.P267T|NRCAM_ENST00000413765.2_Missense_Mutation_p.P254T			Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule	273	Ig-like 3.				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(1)|lung(36)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	65						TTGCCTTCTGGAGTTAAAAAT	0.363000													34	68					6.2361e-21	8.00635e-21	1	1	0
TSPYL4	23270	broad.mit.edu	37	6	116573934	116573934	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:116573934G>C	ENST00000420283.1	-	1	1327	c.1238C>G	c.(1237-1239)tCt>tGt	p.S413C		NM_021648.4	NP_067680.3	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	413					nucleosome assembly	nucleus				endometrium(2)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(2)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		AGATTAGCCAGACTGGAACCT	0.532000													4	4					0	0	1	0	0
TGIF2LX	90316	broad.mit.edu	37	X	89177383	89177383	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:89177383G>T	ENST00000561129.2	+	1	429	c.299G>T	c.(298-300)tGg>tTg	p.W100L	TGIF2LX_ENST00000283891.5_Missense_Mutation_p.W100L			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	100						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						ATTTCTAACTGGTTTATCAAT	0.468000													86	26					4.18329e-38	5.94625e-38	1	1	0
INO80	54617	broad.mit.edu	37	15	41347502	41347502	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:41347502C>A	ENST00000361937.3	-	18	2555	c.2131G>T	c.(2131-2133)Gaa>Taa	p.E711*	INO80_ENST00000401393.3_Nonsense_Mutation_p.E711*			Q9ULG1	INO80_HUMAN	INO80 complex subunit	711	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAAAACCATTCATTAAATTCC	0.368000													6	55					5.4927e-09	5.95666e-09	1	1	0
MMP7	4316	broad.mit.edu	37	11	102401431	102401431	+	Translation_Start_Site	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:102401431T>A	ENST00000260227.4	-	1	53	c.1A>T	c.(1-3)Atg>Ttg	p.M1L		NM_002423.3	NP_002414.1	P09237	MMP7_HUMAN	matrix metallopeptidase 7 (matrilysin, uterine)	1					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(6)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	12	all_cancers(8;2.04e-05)|all_epithelial(12;0.00053)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0105)|all cancers(10;0.0496)|Lung(13;0.109)|LUSC - Lung squamous cell carcinoma(19;0.151)	BRCA - Breast invasive adenocarcinoma(274;0.0147)		GTGAGTCGCATAGCTGCCGTC	0.547000													8	105					0	0	1	0	0
MCAM	4162	broad.mit.edu	37	11	119181112	119181112	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:119181112C>G	ENST00000264036.4	-	15	1872	c.1858G>C	c.(1858-1860)Gag>Cag	p.E620Q	MCAM_ENST00000392814.1_3'UTR	NM_006500.2	NP_006491.2	P43121	MUC18_HUMAN	melanoma cell adhesion molecule	620					anatomical structure morphogenesis|cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|skin(1)	22		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;3.78e-05)		AGGCCCATCTCTTCTGGGAGC	0.602000													44	187					0	0	1	0	0
TP53TG3D	729264	broad.mit.edu	37	16	32265037	32265037	+	Splice_Site	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:32265037G>T	ENST00000398664.3	+	1	997		c.e1+1		TP53TG3D_ENST00000569631.1_Intron|RP11-56L13.7_ENST00000562604.1_RNA|TP53TG3D_ENST00000354614.3_Splice_Site	NM_001243722.1	NP_001230651.1			TP53 target 3D																		GGTTGTCAAGGTAACGCTCCT	0.597000													23	65					2.21704e-12	2.52109e-12	1	1	0
MYO3A	53904	broad.mit.edu	37	10	26432416	26432416	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:26432416G>T	ENST00000265944.5	+	21	2468	c.2302G>T	c.(2302-2304)Gaa>Taa	p.E768*	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	768	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						TAGAGTTATTGAATATGAGGA	0.343000													20	46					5.45024e-15	6.53372e-15	1	1	0
OR5M3	219482	broad.mit.edu	37	11	56237443	56237443	+	Silent	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:56237443A>G	ENST00000312240.2	-	1	571	c.531T>C	c.(529-531)tgT>tgC	p.C177C		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					GTGGATCTGCACAGTAGAAAT	0.413000													73	97					0	0	1	0	0
FAM102A	399665	broad.mit.edu	37	9	130712784	130712784	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr9:130712784G>A	ENST00000373095.1	-	4	707	c.332C>T	c.(331-333)gCg>gTg	p.A111V	FAM102A_ENST00000373084.4_5'UTR|FAM102A_ENST00000300434.3_5'UTR	NM_001035254.2	NP_001030331.1	Q5T9C2	F102A_HUMAN	family with sequence similarity 102, member A	111										breast(1)|cervix(1)|large_intestine(3)|lung(1)|ovary(4)	10						GCCCGAGCCCGCAAACTCGGC	0.632000													4	96					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	84028152	84028152	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:84028152G>T	ENST00000280241.8	-	1	36	c.37C>A	c.(37-39)Cgg>Agg	p.R13R	DLG2_ENST00000376104.2_Intron|DLG2_ENST00000543673.1_Intron|DLG2_ENST00000532653.1_Intron|DLG2_ENST00000398309.2_Intron|DLG2_ENST00000398301.2_Silent_p.R13R|DLG2_ENST00000524982.1_Intron	NM_001206769.1	NP_001193698.1	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	0						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				TCGGACCCCCGGCTGCAGCTG	0.582000													258	106					6.99405e-162	1.07893e-161	1	1	0
PARPBP	55010	broad.mit.edu	37	12	102589974	102589974	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:102589974G>T	ENST00000327680.2	+	12	1865	c.1402G>T	c.(1402-1404)Ggc>Tgc	p.G468C	PARPBP_ENST00000378128.3_3'UTR|PARPBP_ENST00000541394.1_Missense_Mutation_p.G626C|PARPBP_ENST00000392911.2_Missense_Mutation_p.G468C|PARPBP_ENST00000358383.5_Missense_Mutation_p.G549C|PARPBP_ENST00000543784.1_3'UTR|PARPBP_ENST00000535811.1_3'UTR	NM_017915.3	NP_060385.3	Q9NWS1	PR1BP_HUMAN	PARP1 binding protein	549					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding			endometrium(1)|lung(8)|urinary_tract(2)	11						TAGATTGTACGGCAAACTAGC	0.323000													17	48					1.56452e-12	1.78931e-12	1	1	0
DEFB115	245929	broad.mit.edu	37	20	29847301	29847301	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:29847301T>C	ENST00000400552.1	+	2	133	c.133T>C	c.(133-135)Tgc>Cgc	p.C45R		NM_001037730.1	NP_001032819.1	Q30KQ5	DB115_HUMAN	defensin, beta 115	45					defense response to bacterium	extracellular region				kidney(1)|lung(3)|ovary(1)|skin(1)	6			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			AACTGGCAGATGCAGGAAATC	0.313000													13	50					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982002	7982002	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:7982002A>G	ENST00000328600.2	-	2	1318	c.1157T>C	c.(1156-1158)aTg>aCg	p.M386T		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	386	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GACGTAAGCCATGAAGATGTC	0.572000													23	9					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52609325	52609325	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:52609325G>T	ENST00000399231.3	-	39	5497	c.5254C>A	c.(5254-5256)Caa>Aaa	p.Q1752K	MYO5A_ENST00000553916.1_Missense_Mutation_p.Q1750K|MYO5A_ENST00000358212.6_Missense_Mutation_p.Q1777K|MYO5A_ENST00000356338.6_Missense_Mutation_p.Q1725K|MYO5A_ENST00000399233.2_Missense_Mutation_p.Q1749K	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	1752	Dilute.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		TGCAAAAGTTGAGCAGCCTGA	0.428000													31	33					5.60225e-13	6.42563e-13	1	1	0
CD163	9332	broad.mit.edu	37	12	7639097	7639097	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:7639097G>T	ENST00000359156.4	-	10	2658	c.2456C>A	c.(2455-2457)tCa>tAa	p.S819*	CD163_ENST00000396620.3_Nonsense_Mutation_p.S852*|CD163_ENST00000432237.2_Nonsense_Mutation_p.S819*|CD163_ENST00000541972.1_Nonsense_Mutation_p.S807*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	819	SRCR 7.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TAATTTACCTGAGCAGATAAC	0.433000													56	62					5.80444e-35	8.0775e-35	1	1	0
TRHDE	29953	broad.mit.edu	37	12	72893350	72893350	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:72893350G>T	ENST00000261180.4	+	6	1618	c.1522G>T	c.(1522-1524)Gta>Tta	p.V508L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	508					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTCCCATCCAGTATCACAGGA	0.453000													19	38					2.37509e-13	2.75594e-13	1	1	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338260	13338260	+	RNA	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:13338260A>G	ENST00000602906.1	+	0	278																				kidney(3)|lung(1)	4						GATGCCTTGGACAAGATTCGC	0.423000													33	41					0	0	1	0	0
TCP10L2	401285	broad.mit.edu	37	6	167585686	167585686	+	Silent	SNP	G	G	A	rs35001773		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:167585686G>A	ENST00000366832.2	+	2	185	c.54G>A	c.(52-54)gaG>gaA	p.E18E		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	18										endometrium(1)|kidney(2)|lung(3)	6						CCCACCCAGAGGACCCGTGCC	0.662000													7	16					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109098878	109098878	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:109098878G>C	ENST00000309863.6	+	11	4030	c.3316G>C	c.(3316-3318)Gaa>Caa	p.E1106Q		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1106					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ATTAGAAGCTGAAAAACTTCA	0.318000													12	17					0	0	1	0	0
CCDC47	57003	broad.mit.edu	37	17	61833645	61833645	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:61833645G>A	ENST00000225726.5	-	8	1285	c.903C>T	c.(901-903)atC>atT	p.I301I	CCDC47_ENST00000403162.3_Silent_p.I301I|CCDC47_ENST00000582252.1_Silent_p.I301I	NM_020198.2	NP_064583.2	Q96A33	CCD47_HUMAN	coiled-coil domain containing 47	301						integral to membrane	protein binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	18						TCTCTGACAGGATGGCCAAAG	0.438000													38	79					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86265490	86265490	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:86265490G>T	ENST00000394518.2	+	25	6503	c.6408G>T	c.(6406-6408)agG>agT	p.R2136S	AKAP13_ENST00000394510.2_Missense_Mutation_p.R381S|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000361243.2_Missense_Mutation_p.R2140S	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2136	DH.|Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						TTGTTAGAAGGCTTGGAATTC	0.428000													72	157					2.14232e-31	2.94016e-31	1	1	0
NAV3	89795	broad.mit.edu	37	12	78225255	78225255	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:78225255G>T	ENST00000397909.2	+	1	187	c.14G>T	c.(13-15)gGg>gTg	p.G5V	NAV3_ENST00000228327.6_Missense_Mutation_p.G5V|NAV3_ENST00000536525.2_Missense_Mutation_p.G5V|NAV3_ENST00000266692.7_Missense_Mutation_p.G5V			Q8IVL0	NAV3_HUMAN	neuron navigator 3	5						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCTGTTCTTGGGGTTGCCTCA	0.453000										HNSCC(70;0.22)			52	91					3.30226e-22	4.30918e-22	1	1	0
PCDH7	5099	broad.mit.edu	37	4	30725689	30725689	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:30725689T>A	ENST00000361762.2	+	1	3653	c.2645T>A	c.(2644-2646)aTt>aAt	p.I882N	PCDH7_ENST00000543491.1_Missense_Mutation_p.I882N	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	882					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						AGTATTGTCATTGGCGTGGTT	0.438000													53	105					0	0	1	0	0
LRRC6	23639	broad.mit.edu	37	8	133673713	133673713	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:133673713C>T	ENST00000519595.1	-	2	269	c.171G>A	c.(169-171)ggG>ggA	p.G57G	LRRC6_ENST00000250173.1_Silent_p.G57G|LRRC6_ENST00000520446.1_5'UTR|LRRC6_ENST00000518642.1_Silent_p.G57G			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	57						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TACCAATTTTCCCAATAAGAT	0.338000													6	23					0	0	1	0	0
WDR37	22884	broad.mit.edu	37	10	1118122	1118122	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:1118122G>T	ENST00000358220.1	+	2	171	c.27G>T	c.(25-27)tcG>tcT	p.S9S	WDR37_ENST00000263150.4_Silent_p.S9S|WDR37_ENST00000381329.1_Silent_p.S9S			Q9Y2I8	WDR37_HUMAN	WD repeat domain 37	9										breast(2)|endometrium(2)|kidney(1)|lung(9)|prostate(2)|skin(1)	17		all_epithelial(10;0.0449)|Colorectal(49;0.142)		Epithelial(11;0.134)		CAAGTTGTTCGACTGCTCGCC	0.463000													35	66					4.90274e-10	5.43535e-10	1	1	0
DDB1	1642	broad.mit.edu	37	11	61081147	61081147	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:61081147C>G	ENST00000301764.7	-	16	2290	c.1893G>C	c.(1891-1893)ttG>ttC	p.L631F	DDB1_ENST00000450997.2_Intron	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	631	Interaction with CDT1.|Interaction with CUL4A.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						GCTGGGTGCCCAAAGTCACCT	0.483000								Nucleotide excision repair (NER)					10	5					0	0	1	0	0
RBBP9	10741	broad.mit.edu	37	20	18470621	18470621	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:18470621G>A	ENST00000337227.4	-	5	423	c.348C>T	c.(346-348)cgC>cgT	p.R116R	RBBP9_ENST00000493184.1_5'UTR	NM_006606.2	NP_006597.2	O75884	RBBP9_HUMAN	retinoblastoma binding protein 9	116						cytoplasm|nucleus	hydrolase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|prostate(1)	9						ACTGCCAGGGGCGGGTGAAGT	0.473000													5	8					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140573768	140573768	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:140573768G>T	ENST00000239446.4	+	1	1827	c.1643G>T	c.(1642-1644)cGc>cTc	p.R548L		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		548	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.R548H(1)		breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGCTGGTGCGCGTGCTGGTG	0.721000													24	49					4.7796e-09	5.21173e-09	1	1	0
POLQ	10721	broad.mit.edu	37	3	121207289	121207289	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:121207289C>A	ENST00000264233.5	-	16	4617	c.4489G>T	c.(4489-4491)Gac>Tac	p.D1497Y		NM_199420.3	NP_955452.3	O75417	DPOLQ_HUMAN	polymerase (DNA directed), theta	1497					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(55)|ovary(5)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	120				GBM - Glioblastoma multiforme(114;0.0915)		ACTAGATAGTCATCACTGAAG	0.358000								DNA polymerases (catalytic subunits)					52	23					2.97546e-10	3.31717e-10	1	1	0
TENM2	57451	broad.mit.edu	37	5	167420020	167420020	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:167420020C>G	ENST00000519204.1	+	4	774	c.656C>G	c.(655-657)aCc>aGc	p.T219S	TENM2_ENST00000520394.1_Missense_Mutation_p.T149S|TENM2_ENST00000545108.1_Missense_Mutation_p.T340S|TENM2_ENST00000403607.2_Missense_Mutation_p.T173S|TENM2_ENST00000518659.1_Missense_Mutation_p.T340S					teneurin transmembrane protein 2																		TACCCTTTGACCTCAGGAACG	0.572000													64	32					0	0	1	0	0
LTBP4	8425	broad.mit.edu	37	19	41105433	41105433	+	Silent	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:41105433A>G	ENST00000308370.7	+	3	312	c.312A>G	c.(310-312)agA>agG	p.R104R	LTBP4_ENST00000545697.1_5'UTR|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000204005.9_Silent_p.R67R	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	104					growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGAGGAAGAGACAGGTGTCCC	0.637000													63	30					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106737182	106737182	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:106737182C>G	ENST00000369701.3	+	4	1112	c.885C>G	c.(883-885)ttC>ttG	p.F295L		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	295						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGCTCACCTTCTATATCCAGA	0.443000													20	28					0	0	1	0	0
OR4A15	81328	broad.mit.edu	37	11	55135632	55135632	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:55135632G>T	ENST00000314706.3	+	1	273	c.273G>T	c.(271-273)ctG>ctT	p.L91L		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ACTTTTTTCTGGCTTCTTTAT	0.423000													56	71					2.17656e-39	3.10491e-39	1	1	0
HAVCR2	84868	broad.mit.edu	37	5	156514229	156514229	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:156514229T>A	ENST00000307851.4	-	7	1520	c.790A>T	c.(790-792)Atc>Ttc	p.I264F	HAVCR2_ENST00000522593.1_Missense_Mutation_p.I236F	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	264						integral to membrane				cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGGTATAGATGTTTTCTTCT	0.473000													7	47					0	0	1	0	0
CCDC73	493860	broad.mit.edu	37	11	32781805	32781805	+	Splice_Site	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:32781805C>T	ENST00000531481.1	-	2	262		c.e2-1		CCDC73_ENST00000534415.1_Splice_Site|CCDC73_ENST00000335185.5_Splice_Site			Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TATTTATTTCCTGTAATGTAA	0.284000													15	32					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967630	142967630	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:142967630C>A	ENST00000370494.1	+	1	458	c.428C>A	c.(427-429)gCa>gAa	p.A143E		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	143							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGCTAGAGCATGGACTAGG	0.428000													147	23					3.18226e-76	4.85265e-76	1	1	0
NOX4	50507	broad.mit.edu	37	11	89133480	89133480	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:89133480C>G	ENST00000535633.1	-	10	1152	c.842G>C	c.(841-843)aGc>aCc	p.S281T	NOX4_ENST00000527956.1_Missense_Mutation_p.S281T|NOX4_ENST00000534731.1_Missense_Mutation_p.S305T|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000528341.1_Missense_Mutation_p.S280T|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000413594.2_Missense_Mutation_p.S326T|NOX4_ENST00000532825.1_Missense_Mutation_p.S281T|NOX4_ENST00000424319.1_Missense_Mutation_p.S281T|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000527626.1_Missense_Mutation_p.S139T|NOX4_ENST00000263317.4_Missense_Mutation_p.S305T|NOX4_ENST00000343727.5_Missense_Mutation_p.S281T|NOX4_ENST00000542487.1_Missense_Mutation_p.S281T	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	305	Ferric oxidoreductase.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TGGCTTATTGCTCCGGATATA	0.408000													18	111					0	0	1	0	0
MYLK3	91807	broad.mit.edu	37	16	46755046	46755046	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:46755046C>A	ENST00000394809.4	-	9	2089	c.1974G>T	c.(1972-1974)ggG>ggT	p.G658G	MYLK3_ENST00000536476.1_Silent_p.G317G	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	658	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TTCTGGCCAGCCCAAAGTCAA	0.453000													53	54					3.77215e-22	4.90627e-22	1	1	0
RGS3	5998	broad.mit.edu	37	9	116226104	116226104	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr9:116226104G>A	ENST00000317613.6	+	1	93	c.22G>A	c.(22-24)Gtc>Atc	p.V8I	RGS3_ENST00000350696.5_Intron|RGS3_ENST00000374140.2_Intron	NM_017790.3	NP_060260.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	0					inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity			cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						CCTGCACCGCGTCTCCCTCGG	0.687000													33	6					0	0	1	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718317	103718317	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:103718317G>T	ENST00000245312.3	-	1	879	c.283C>A	c.(283-285)Ctc>Atc	p.L95I		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	95					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					ACGGCCTGGAGCGGGAGGATG	0.547000													53	16					1.84395e-34	2.55712e-34	1	1	0
MGA	23269	broad.mit.edu	37	15	42041930	42041930	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:42041930G>C	ENST00000219905.7	+	17	6306	c.6125G>C	c.(6124-6126)tGt>tCt	p.C2042S	MGA_ENST00000545763.1_Missense_Mutation_p.C1833S|MGA_ENST00000566586.1_Missense_Mutation_p.C1833S|MGA_ENST00000570161.1_Missense_Mutation_p.C2042S|MGA_ENST00000389936.4_Missense_Mutation_p.C2003S	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	2003						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GAAGAAGGTTGTGCAACTGTC	0.408000													65	106					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124882717	124882717	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:124882717C>G	ENST00000356219.3	-	17	1979	c.1824G>C	c.(1822-1824)gaG>gaC	p.E608D	NCOR2_ENST00000404621.1_Missense_Mutation_p.E607D|NCOR2_ENST00000397355.1_Missense_Mutation_p.E608D|NCOR2_ENST00000404121.2_Missense_Mutation_p.E178D|NCOR2_ENST00000429285.2_Missense_Mutation_p.E607D|NCOR2_ENST00000405201.1_Missense_Mutation_p.E608D	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	608					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TCTCATTCAGCTCCATGGAGG	0.537000													43	31					0	0	1	0	0
FTHL17	53940	broad.mit.edu	37	X	31089931	31089931	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:31089931A>G	ENST00000359202.3	-	1	239	c.140T>C	c.(139-141)gTg>gCg	p.V47A		NM_031894.2	NP_114100.1	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	47	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	23						CTCCAGGGCCACGTCGTCCCG	0.592000													78	11					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47117638	47117638	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:47117638C>T	ENST00000562435.1	-	9	1456	c.1072G>A	c.(1072-1074)Gtc>Atc	p.V358I	NETO2_ENST00000303155.5_Missense_Mutation_p.V351I	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	358						integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				AGGACCAAGACAATCCCTGAA	0.358000										HNSCC(25;0.065)			21	64					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50129405	50129405	+	RNA	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:50129405G>T	ENST00000376025.2	-	0	2357							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					GGAGACTCTGGGCCTTTGTAG	0.463000													39	10					4.18559e-23	5.4979e-23	1	1	0
ABCB8	11194	broad.mit.edu	37	7	150730816	150730816	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:150730816G>T	ENST00000358849.4	+	2	313	c.220G>T	c.(220-222)Gtt>Ttt	p.V74F	ABCB8_ENST00000356058.4_Missense_Mutation_p.V111F|ABCB8_ENST00000498578.1_Missense_Mutation_p.V74F|ABCB8_ENST00000542328.1_Intron|ABCB8_ENST00000493338.1_3'UTR|ABCB8_ENST00000297504.6_Missense_Mutation_p.V91F|ABCB8_ENST00000477719.1_Missense_Mutation_p.V74F|ABCB8_ENST00000477092.1_Missense_Mutation_p.V74F	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	91						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTGGTGCTGGGTTGGGGGAGC	0.692000													42	50					4.44712e-29	6.0408e-29	1	1	0
PALM2-AKAP2	445815	broad.mit.edu	37	9	112900123	112900123	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr9:112900123C>T	ENST00000374530.3	+	8	2479	c.2299C>T	c.(2299-2301)Cga>Tga	p.R767*	AKAP2_ENST00000374525.1_Nonsense_Mutation_p.R625*|PALM2-AKAP2_ENST00000302798.7_Nonsense_Mutation_p.R767*|AKAP2_ENST00000510514.5_Nonsense_Mutation_p.R767*|AKAP2_ENST00000434623.2_Nonsense_Mutation_p.R625*|AKAP2_ENST00000259318.7_Nonsense_Mutation_p.R536*|AKAP2_ENST00000555236.1_Nonsense_Mutation_p.R767*	NM_007203.4|NM_147150.2	NP_009134.1|NP_671492.1	Q9Y2D5	AKAP2_HUMAN		536							enzyme binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	44						CTCAGAGGGCCGAGGAGAAGG	0.532000													24	63					0	0	1	0	0
PNN	5411	broad.mit.edu	37	14	39646860	39646860	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:39646860G>A	ENST00000216832.4	+	5	458	c.391G>A	c.(391-393)Gat>Aat	p.D131N	PNN_ENST00000556530.1_3'UTR|PNN_ENST00000553331.1_Intron	NM_002687.3	NP_002678.2	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	131	Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)|stomach(1)	27	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		CCTTATCCAGGATCAAAATAT	0.388000													38	252					0	0	1	0	0
TKTL2	84076	broad.mit.edu	37	4	164394359	164394359	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:164394359C>G	ENST00000280605.3	-	1	688	c.528G>C	c.(526-528)ttG>ttC	p.L176F		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	176						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CGAGATTGTCCAAGTTGTAGT	0.552000													39	8					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114257891	114257891	+	Silent	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:114257891T>C	ENST00000357077.4	+	31	3803	c.3750T>C	c.(3748-3750)ggT>ggC	p.G1250G	ANK2_ENST00000264366.6_Silent_p.G1217G|ANK2_ENST00000509550.1_Silent_p.G426G|ANK2_ENST00000504887.1_3'UTR|ANK2_ENST00000506722.1_Silent_p.G1241G|ANK2_ENST00000394537.3_Silent_p.G1250G	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1217					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGTTGAATGGTTTTGGGGGAG	0.408000													62	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179594462	179594462	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:179594462C>A	ENST00000589042.1	-	63	18742	c.18518G>T	c.(18517-18519)aGt>aTt	p.S6173I	TTN_ENST00000591111.1_Missense_Mutation_p.S5856I|TTN_ENST00000342992.6_Missense_Mutation_p.S4929I|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5856	Ig-like 43.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAAGTCCCACTATTTTCTAC	0.433000													47	58					6.4308e-24	8.47503e-24	1	1	0
C7orf60	154743	broad.mit.edu	37	7	112461863	112461863	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:112461863C>G	ENST00000297145.4	-	5	1319	c.1154G>C	c.(1153-1155)gGa>gCa	p.G385A		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	385										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						TTGACTTTCTCCAGAATCTGA	0.408000													42	60					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176671783	176671783	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:176671783G>C	ENST00000367662.3	+	9	4441	c.3277G>C	c.(3277-3279)Gct>Cct	p.A1093P		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1093					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CCAAGTTCTAGCTGAAGCTGG	0.512000													12	45					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495399	20495399	+	RNA	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:20495399C>T	ENST00000555186.1	+	0	602					NR_038836.1																						TCAAGATCTTCTGTGTGAGGA	0.403000													11	65					0	0	1	0	0
EFHD2	79180	broad.mit.edu	37	1	15736746	15736746	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:15736746G>T	ENST00000375980.4	+	1	356	c.279G>T	c.(277-279)caG>caT	p.Q93H		NM_024329.5	NP_077305.2	Q96C19	EFHD2_HUMAN	EF-hand domain family, member D2	93	EF-hand 1.					membrane raft				large_intestine(1)|skin(1)	2		Renal(390;0.00145)|Breast(348;0.00173)|Colorectal(325;0.00215)|all_lung(284;0.00366)|Lung NSC(340;0.00395)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)|Hepatocellular(190;0.152)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.59e-07)|COAD - Colon adenocarcinoma(227;3.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000119)|KIRC - Kidney renal clear cell carcinoma(229;0.00251)|STAD - Stomach adenocarcinoma(313;0.00727)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGAAGCAGATCAAGGACA	0.687000													11	61					0.0167234	0.0168932	1	1	0
DLG1	1739	broad.mit.edu	37	3	197009570	197009570	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:197009570T>A	ENST00000346964.2	-	4	487	c.298A>T	c.(298-300)Agc>Tgc	p.S100C	DLG1_ENST00000450955.1_Missense_Mutation_p.S100C|DLG1_ENST00000422288.1_Missense_Mutation_p.S100C|DLG1_ENST00000419354.1_Missense_Mutation_p.S100C|DLG1_ENST00000392382.2_Missense_Mutation_p.S100C|DLG1_ENST00000485409.1_5'UTR|DLG1_ENST00000357674.4_Missense_Mutation_p.S100C|DLG1_ENST00000314062.3_Missense_Mutation_p.S100C|DLG1_ENST00000448528.2_Missense_Mutation_p.S100C	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	100					actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GGGCTAAGGCTGCTTGGCAGT	0.373000													75	23					0	0	1	0	0
MED20	9477	broad.mit.edu	37	6	41884592	41884592	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:41884592C>A	ENST00000265350.4	-	2	180	c.100G>T	c.(100-102)Gag>Tag	p.E34*	MED20_ENST00000467535.1_5'UTR|MED20_ENST00000409312.1_Nonsense_Mutation_p.E34*|MED20_ENST00000409060.1_Nonsense_Mutation_p.E34*	NM_004275.3	NP_004266.2	Q9H944	MED20_HUMAN	mediator complex subunit 20	34					regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	mediator complex	DNA-directed RNA polymerase activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)|pancreas(1)	5	Colorectal(47;0.121)		STAD - Stomach adenocarcinoma(11;0.000204)|Epithelial(12;0.000367)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCTTGCTTCTCTGCCCCAAGC	0.547000													16	91					4.75885e-15	5.72212e-15	1	1	0
NPTX2	4885	broad.mit.edu	37	7	98256543	98256543	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:98256543C>A	ENST00000265634.3	+	4	1120	c.955C>A	c.(955-957)Cgg>Agg	p.R319R		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	319	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			CTGGACGACACGGGATGGCAT	0.627000													36	71					3.99972e-41	5.78868e-41	1	1	0
FSD1	79187	broad.mit.edu	37	19	4318438	4318438	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:4318438G>T	ENST00000221856.6	+	9	1042	c.895G>T	c.(895-897)Gat>Tat	p.D299Y	FSD1_ENST00000597590.1_Missense_Mutation_p.D299Y|FSD1_ENST00000598010.1_3'UTR	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	299	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GAAGGTGCAGGATATCAAGGC	0.632000													23	13					5.52252e-06	5.79937e-06	1	1	0
FJX1	24147	broad.mit.edu	37	11	35641239	35641239	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:35641239T>A	ENST00000317811.4	+	1	1505	c.1055T>A	c.(1054-1056)aTg>aAg	p.M352K	FJX1_ENST00000532914.1_3'UTR	NM_014344.3	NP_055159.2	Q86VR8	FJX1_HUMAN	four jointed box 1 (Drosophila)	352						extracellular space				lung(1)|urinary_tract(1)	2	all_cancers(35;0.177)|all_lung(20;0.0238)|Lung NSC(22;0.0494)|all_epithelial(35;0.0739)	all_hematologic(20;0.107)				GTAGCAGGCATGTGGGACAAG	0.682000													8	11					0	0	1	0	0
EXTL3	2137	broad.mit.edu	37	8	28575527	28575527	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:28575527C>G	ENST00000220562.4	+	3	2853	c.1951C>G	c.(1951-1953)Cag>Gag	p.Q651E	EXTL3_ENST00000519886.1_Intron|EXTL3_ENST00000523149.1_Missense_Mutation_p.Q267E	NM_001440.2	NP_001431.1	O43909	EXTL3_HUMAN	exostosin-like glycosyltransferase 3	651						integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding|protein binding			biliary_tract(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(8)|ovary(1)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(1)	36		Ovarian(32;0.069)		KIRC - Kidney renal clear cell carcinoma(542;0.107)|Kidney(114;0.129)|Colorectal(74;0.228)		CAAGGAATTTCAGGCAGCGCT	0.542000													10	78					0	0	1	0	0
ZBTB16	7704	broad.mit.edu	37	11	113934379	113934379	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:113934379G>A	ENST00000335953.4	+	2	737	c.357G>A	c.(355-357)ctG>ctA	p.L119L	ZBTB16_ENST00000392996.2_Silent_p.L119L	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	119					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		AACAGTGCCTGAAGATGCTGG	0.607000													44	16					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2749726	2749726	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:2749726G>C	ENST00000382611.6	-	2	673	c.425C>G	c.(424-426)cCc>cGc	p.P142R	IRX2_ENST00000302057.5_Missense_Mutation_p.P142R|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	142						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		GCCCTTGGTGGGGTAGGGGTT	0.642000													47	91					0	0	1	0	0
TMEM70	54968	broad.mit.edu	37	8	74893845	74893845	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:74893845G>A	ENST00000312184.5	+	3	845	c.772G>A	c.(772-774)Gat>Aat	p.D258N		NM_001040613.2|NM_017866.5	NP_001035703.1|NP_060336.3	Q9BUB7	TMM70_HUMAN	transmembrane protein 70	258					mitochondrial proton-transporting ATP synthase complex assembly	integral to mitochondrial membrane|mitochondrial inner membrane				breast(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	8	Breast(64;0.0311)		Epithelial(68;0.0186)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0564)			ACGGCATAAAGATGACAAATG	0.333000													28	6					0	0	1	0	0
SULT4A1	25830	broad.mit.edu	37	22	44237733	44237733	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr22:44237733G>C	ENST00000330884.4	-	2	369	c.249C>G	c.(247-249)gaC>gaG	p.D83E	SULT4A1_ENST00000540422.1_Intron|SULT4A1_ENST00000249130.5_Missense_Mutation_p.D83E	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	83					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		GGAGCTGCTCGTCGATGTTCA	0.617000													88	25					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167675786	167675786	+	Silent	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:167675786T>A	ENST00000357154.3	-	9	950	c.813A>T	c.(811-813)tcA>tcT	p.S271S	SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000512681.1_Silent_p.S173S|SPOCK3_ENST00000541637.1_Silent_p.S173S|SPOCK3_ENST00000506886.1_Silent_p.S271S|SPOCK3_ENST00000421836.2_Silent_p.S220S|SPOCK3_ENST00000511531.1_Silent_p.S271S|SPOCK3_ENST00000504953.1_Silent_p.S268S|SPOCK3_ENST00000511269.1_Silent_p.S268S|SPOCK3_ENST00000541354.1_Silent_p.S151S|SPOCK3_ENST00000535728.1_Silent_p.S139S|SPOCK3_ENST00000502330.1_Silent_p.S271S|SPOCK3_ENST00000534949.1_Silent_p.S175S|SPOCK3_ENST00000510741.1_Silent_p.S228S|SPOCK3_ENST00000512648.1_Silent_p.S268S|SPOCK3_ENST00000357545.4_Silent_p.S268S	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	271					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TTCTGAGCTCTGACTGGTCCA	0.388000													103	28					0	0	1	0	0
XRN1	54464	broad.mit.edu	37	3	142084003	142084003	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:142084003C>T	ENST00000264951.4	-	29	3397	c.3280G>A	c.(3280-3282)Gga>Aga	p.G1094R	XRN1_ENST00000392981.2_Missense_Mutation_p.G1094R	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	1094					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						GGAATGACTCCATGTTGCTGT	0.363000													77	17					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049995	49049995	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:49049995A>G	ENST00000395474.3	+	2	1398	c.1118A>G	c.(1117-1119)aAg>aGg	p.K373R	WDR6_ENST00000415265.2_Intron|WDR6_ENST00000489684.1_3'UTR|WDR6_ENST00000448293.1_Missense_Mutation_p.K292R	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	343					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		CTCTGCTTCAAGTCCCGTAGT	0.602000													89	34					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12954977	12954977	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:12954977C>A	ENST00000235347.4	-	3	385	c.306G>T	c.(304-306)gtG>gtT	p.V102V		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	102										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCAAATCCAGCACTTGAAGTT	0.527000													45	143					7.1157e-29	9.60016e-29	1	1	0
GRSF1	2926	broad.mit.edu	37	4	71697287	71697287	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:71697287G>C	ENST00000254799.6	-	5	1036	c.919C>G	c.(919-921)Ctg>Gtg	p.L307V	GRSF1_ENST00000545193.1_Missense_Mutation_p.L189V|GRSF1_ENST00000439371.1_Missense_Mutation_p.L145V|GRSF1_ENST00000508091.1_Intron|GRSF1_ENST00000502323.1_Missense_Mutation_p.L145V	NM_002092.3	NP_002083.3	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1	307	RRM 2.				mRNA polyadenylation		mRNA binding|nucleotide binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|upper_aerodigestive_tract(2)	17		all_hematologic(202;0.21)	Lung(101;0.235)			TGTTTCAACAGGGCTTGGTTG	0.393000													33	45					0	0	1	0	0
PLBD2	196463	broad.mit.edu	37	12	113821954	113821954	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:113821954G>T	ENST00000280800.3	+	7	1033	c.1002G>T	c.(1000-1002)tgG>tgT	p.W334C	PLBD2_ENST00000545182.2_Missense_Mutation_p.W334C	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	334					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						CAGCCCTGTGGAAGTATGTGC	0.622000													25	20					1.30897e-18	1.63314e-18	1	1	0
PROKR1	10887	broad.mit.edu	37	2	68882524	68882524	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:68882524G>A	ENST00000303786.3	+	3	1418	c.998G>A	c.(997-999)aGc>aAc	p.S333N	PROKR1_ENST00000394342.2_Missense_Mutation_p.S333N			Q8TCW9	PKR1_HUMAN	prokineticin receptor 1	333						integral to membrane|plasma membrane	neuropeptide Y receptor activity			endometrium(3)|kidney(2)|large_intestine(14)|lung(9)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						ATCGCCATGAGCAACAGCATG	0.498000													36	74					0	0	1	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162620	90162620	+	RNA	SNP	T	T	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:90162620T>G	ENST00000564451.1	+	0	1973																											CTAGGTAAAGTGGGGAAGCAG	0.483000													4	132					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66280007	66280007	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:66280007G>A	ENST00000273854.3	-	7	2282	c.1682C>T	c.(1681-1683)cCa>cTa	p.P561L	EPHA5_ENST00000511294.1_Missense_Mutation_p.P561L|EPHA5_ENST00000354839.4_Missense_Mutation_p.P561L|EPHA5_ENST00000432638.2_Missense_Mutation_p.P397L	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	561					cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CTTACACACTGGGGTGGTTTC	0.453000										TSP Lung(17;0.13)			65	93					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9416281	9416281	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:9416281A>T	ENST00000378501.2	+	25	2578	c.2563A>T	c.(2563-2565)Atg>Ttg	p.M855L	PLCB4_ENST00000414679.2_Missense_Mutation_p.M867L|PLCB4_ENST00000334005.3_Missense_Mutation_p.M855L|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.M855L|PLCB4_ENST00000378473.3_Missense_Mutation_p.M867L|PLCB4_ENST00000378493.1_Missense_Mutation_p.M855L	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	855					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						AATGAGAGCTATGGGCATTGA	0.363000													15	32					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161021161	161021161	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:161021161G>A	ENST00000368013.3	-	10	1683	c.1363C>T	c.(1363-1365)Cgg>Tgg	p.R455W	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.R455W|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.R278W	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	455					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			gggcttggCCGGTGCTGTAGA	0.622000													3	39					0	0	1	0	0
AKR7A2	8574	broad.mit.edu	37	1	19632559	19632559	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:19632559C>T	ENST00000235835.3	-	6	892	c.871G>A	c.(871-873)Gtg>Atg	p.V291M		NM_003689.3	NP_003680.2	O43488	ARK72_HUMAN	aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)	291					carbohydrate metabolic process|cellular aldehyde metabolic process	Golgi apparatus	alditol:NADP+ 1-oxidoreductase activity|electron carrier activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00461)|BRCA - Breast invasive adenocarcinoma(304;1.83e-05)|Kidney(64;0.000167)|GBM - Glioblastoma multiforme(114;0.00115)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		GCCGAGGTCACACTGGGGGCG	0.637000													43	46					0	0	1	0	0
RCC2	55920	broad.mit.edu	37	1	17765020	17765020	+	Splice_Site	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:17765020T>C	ENST00000375436.4	-	2	180		c.e2-2		RCC2_ENST00000375433.3_5'UTR	NM_018715.3	NP_061185.1	Q9P258	RCC2_HUMAN	regulator of chromosome condensation 2						cell division|mitotic prometaphase	chromosome, centromeric region|cytosol|microtubule|nucleolus|spindle				breast(2)|endometrium(1)|kidney(3)|large_intestine(7)|lung(4)	17		Colorectal(325;0.000147)|Breast(348;0.00122)|Renal(390;0.00145)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00492)|BRCA - Breast invasive adenocarcinoma(304;7.69e-06)|COAD - Colon adenocarcinoma(227;1.19e-05)|Kidney(64;0.000189)|KIRC - Kidney renal clear cell carcinoma(64;0.00273)|STAD - Stomach adenocarcinoma(196;0.0135)|READ - Rectum adenocarcinoma(331;0.0656)|Lung(427;0.19)		TGGTCGCGGCTGGAGGGAGAC	0.736000													13	13					0	0	1	0	0
LYZL1	84569	broad.mit.edu	37	10	29581597	29581597	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:29581597G>T	ENST00000375500.3	+	3	484	c.427G>T	c.(427-429)Gcc>Tcc	p.A143S		NM_032517.4	NP_115906.3	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	97					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			central_nervous_system(1)|cervix(2)|large_intestine(2)|lung(5)|skin(1)	11		Breast(68;0.203)				CTGCCATGTCGCCTGCTCAGG	0.532000													105	90					2.59595e-41	3.77077e-41	1	1	0
TCP10L	140290	broad.mit.edu	37	21	33956574	33956574	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr21:33956574C>T	ENST00000300258.3	-	2	154	c.41G>A	c.(40-42)gGc>gAc	p.G14D		NM_144659.5	NP_653260.1			t-complex 10-like											breast(1)|central_nervous_system(1)|liver(1)|skin(1)	4						TGGGTGGGTGCCCTCTTTGGG	0.627000													26	39					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124193534	124193534	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:124193534G>A	ENST00000360013.3	+	26	4177	c.4050G>A	c.(4048-4050)aaG>aaA	p.K1350K	KALRN_ENST00000240874.3_Silent_p.K1350K|KALRN_ENST00000460856.1_Silent_p.K1341K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1350	DH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						AGCTGGAGAAGTACGAGCAAC	0.527000													70	25					0	0	1	0	0
CD300LB	124599	broad.mit.edu	37	17	72518979	72518979	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:72518979G>A	ENST00000392621.1	-	4	619	c.615C>T	c.(613-615)gcC>gcT	p.A205A		NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	168						integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						ACCAGAGGATGGCAGTGACCA	0.552000													35	47					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025349	34025349	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:34025349C>A	ENST00000374372.1	-	3	863	c.360G>T	c.(358-360)cgG>cgT	p.R120R	GDF5_ENST00000374369.3_Silent_p.R120R			P43026	GDF5_HUMAN	growth differentiation factor 5	120					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGGTCACAGTCCGGGCTGTAG	0.637000													18	146					9.7654e-05	0.000101479	1	1	0
CABP2	51475	broad.mit.edu	37	11	67288576	67288576	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:67288576C>G	ENST00000294288.4	-	4	368	c.299G>C	c.(298-300)tGc>tCc	p.C100S	CABP2_ENST00000353903.5_Missense_Mutation_p.C43S	NM_016366.2	NP_057450.2	Q9NPB3	CABP2_HUMAN	calcium binding protein 2	100	EF-hand 1.				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	9						CAGCTCCCGGCAGCCAATGTA	0.622000													72	50					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85260840	85260840	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:85260840G>T	ENST00000266682.5	-	10	2169	c.1628C>A	c.(1627-1629)gCt>gAt	p.A543D	SLC6A15_ENST00000552192.1_Missense_Mutation_p.A436D|SLC6A15_ENST00000309283.7_Missense_Mutation_p.A251D	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	543					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						AAAGCATACAGCAATATTCTC	0.303000													21	51					4.87955e-14	5.7288e-14	1	1	0
MYO3B	140469	broad.mit.edu	37	2	171260906	171260906	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:171260906G>T	ENST00000334231.6	+	20	2454	c.2454G>T	c.(2452-2454)ctG>ctT	p.L818L	MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Silent_p.L809L|MYO3B_ENST00000408978.4_Silent_p.L809L			Q8WXR4	MYO3B_HUMAN	myosin IIIB	809	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						ACCAGACCCTGGTTGGTAGGT	0.438000													25	31					6.38683e-12	7.20102e-12	1	1	0
ZP4	57829	broad.mit.edu	37	1	238053933	238053933	+	Translation_Start_Site	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:238053933C>T	ENST00000366570.4	-	1	161	c.3G>A	c.(1-3)atG>atA	p.M1I	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	1					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GCAGCAGCCACATAATGCTAC	0.542000													19	9					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214557235	214557235	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:214557235C>T	ENST00000366956.5	-	13	2157	c.1963G>A	c.(1963-1965)Gcc>Acc	p.A655T	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	655					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		AGCGTCATGGCCTCCATGCCC	0.682000													13	34					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140579369	140579369	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:140579369A>C	ENST00000354757.3	+	1	22	c.22A>C	c.(22-24)Act>Cct	p.T8P	PCDHB11_ENST00000536699.1_5'UTR	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		8					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.T8S(1)		NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGGACACGCACTCAGCAGAT	0.502000													12	9					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50918123	50918123	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr18:50918123G>T	ENST00000442544.2	+	17	3170	c.2554G>T	c.(2554-2556)Gct>Tct	p.A852S	DCC_ENST00000412726.1_Missense_Mutation_p.A680S|DCC_ENST00000581580.1_Missense_Mutation_p.A487S	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	852	Fibronectin type-III 5.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AGGTGTACAGGCTGTGGCTCT	0.537000													92	135					1.64436e-45	2.43292e-45	1	1	0
MEIS2	4212	broad.mit.edu	37	15	37184625	37184625	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:37184625C>A	ENST00000338564.5	-	13	1608	c.1162G>T	c.(1162-1164)Ggt>Tgt	p.G388C	MEIS2_ENST00000561208.1_Missense_Mutation_p.G395C|MEIS2_ENST00000559085.1_3'UTR|MEIS2_ENST00000382766.2_Missense_Mutation_p.G388C|MEIS2_ENST00000397620.2_3'UTR|MEIS2_ENST00000424352.2_3'UTR|MEIS2_ENST00000444725.1_3'UTR|MEIS2_ENST00000557796.2_3'UTR|MEIS2_ENST00000340545.5_3'UTR|MEIS2_ENST00000397624.3_3'UTR|MEIS2_ENST00000219869.9_3'UTR	NM_001220482.1	NP_001207411.1	O14770	MEIS2_HUMAN	Meis homeobox 2	395					negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	36		all_epithelial(112;9.77e-14)|Lung NSC(122;1.42e-09)|all_lung(180;2.2e-08)|Ovarian(310;0.134)|Melanoma(134;0.155)		all cancers(64;9.33e-21)|GBM - Glioblastoma multiforme(113;1.71e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0288)		ATAGGACCACCCTGAGAAACG	0.458000													101	152					6.7584e-44	9.96238e-44	1	1	0
CD93	22918	broad.mit.edu	37	20	23066782	23066782	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:23066782G>T	ENST00000246006.4	-	1	195	c.48C>A	c.(46-48)acC>acA	p.T16T		NM_012072.3	NP_036204.2	Q9NPY3	C1QR1_HUMAN	CD93 molecule	16					cell-cell adhesion|interspecies interaction between organisms|macrophage activation|phagocytosis	plasma membrane	calcium ion binding|complement component C1q binding|receptor activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Colorectal(13;0.0352)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCCCGGGCTGGGTcaggagca	0.726000													6	5					0.00307968	0.00314285	1	1	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389561.2_Silent_p.Q2725Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													3	40					0	0	1	0	0
EVC2	132884	broad.mit.edu	37	4	5682998	5682998	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:5682998C>T	ENST00000310917.2	-	7	1350	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K	EVC2_ENST00000344408.5_Missense_Mutation_p.E287K|EVC2_ENST00000344938.1_Missense_Mutation_p.E287K	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	287						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						GTTACGTTTTCTTCTGCTGTT	0.498000													28	43					0	0	1	0	0
RIPK3	11035	broad.mit.edu	37	14	24807659	24807659	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:24807659G>A	ENST00000216274.5	-	4	804	c.586C>T	c.(586-588)Cgg>Tgg	p.R196W		NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	196	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		GAGGCCTTCCGGTTTACGTTA	0.597000													89	129					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140783111	140783111	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:140783111C>G	ENST00000573521.1	+	1	592	c.592C>G	c.(592-594)Cgc>Ggc	p.R198G	PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGCTGGAGCGCGCCCTGGA	0.637000													17	3					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52383392	52383392	+	Missense_Mutation	SNP	G	G	A	rs141416042	by1000genomes	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:52383392G>A	ENST00000420323.2	+	14	2743	c.2482G>A	c.(2482-2484)Gtg>Atg	p.V828M		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	828	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGCCACTTCCGTGCTGGACAT	0.577000													22	54					0	0	1	0	0
CXorf21	80231	broad.mit.edu	37	X	30578092	30578092	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:30578092T>A	ENST00000378962.3	-	3	703	c.381A>T	c.(379-381)ttA>ttT	p.L127F		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	127										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						CTGCAATCTGTAAGTCATTAT	0.433000													36	12					0	0	1	0	0
ABCF2	10061	broad.mit.edu	37	7	150918711	150918711	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:150918711A>T	ENST00000287844.2	-	7	983	c.874T>A	c.(874-876)Tgt>Agt	p.C292S	ABCF2_ENST00000473874.1_5'UTR|ABCF2_ENST00000222388.2_Missense_Mutation_p.C292S	NM_007189.1	NP_009120.1	Q9UG63	ABCF2_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 2	292	ABC transporter 1.					ATP-binding cassette (ABC) transporter complex|mitochondrial envelope	ATP binding|ATPase activity|transporter activity			breast(1)|central_nervous_system(1)|large_intestine(4)|lung(15)|ovary(1)|skin(2)	24			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATATTGGTACAGACACCATTC	0.438000													94	191					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803636	185803636	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:185803636C>A	ENST00000302277.6	+	4	4107	c.3513C>A	c.(3511-3513)atC>atA	p.I1171I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1171						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AGATGCCAATCATTCCAGCTT	0.512000													37	127					4.0492e-12	4.57836e-12	1	1	0
FADS6	283985	broad.mit.edu	37	17	72878809	72878809	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:72878809G>T	ENST00000310226.6	-	3	403	c.389C>A	c.(388-390)aCg>aAg	p.T130K		NM_178128.3	NP_835229.2	Q8N9I5	FADS6_HUMAN	fatty acid desaturase 6	136					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity			endometrium(3)|kidney(1)|lung(4)	8	all_lung(278;0.172)|Lung NSC(278;0.207)					GTGCCCATGCGTGGCGTGCTC	0.587000													11	15					0.0202918	0.0204459	1	1	0
HECW2	57520	broad.mit.edu	37	2	197172747	197172747	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:197172747T>A	ENST00000260983.2	-	11	2679	c.2497A>T	c.(2497-2499)Acg>Tcg	p.T833S	HECW2_ENST00000409111.1_Missense_Mutation_p.T477S	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	833	Interaction with TP73.|WW 1.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TGCCACGTCGTGGTTCTGTTT	0.572000													14	31					0	0	1	0	0
HERC2P4	100289574	broad.mit.edu	37	16	32163530	32163530	+	RNA	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:32163530C>T	ENST00000564145.1	-	0	65																											GTCACGGTGCCTTCTCCAAAC	0.577000													30	76					0	0	1	0	0
ASH1L	55870	broad.mit.edu	37	1	155451467	155451467	+	Silent	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:155451467T>A	ENST00000368346.3	-	3	1833	c.1194A>T	c.(1192-1194)ggA>ggT	p.G398G	ASH1L_ENST00000392403.3_Silent_p.G398G|ASH1L_ENST00000548830.1_3'UTR			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	398					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TATTAACCAATCCCATTGCTG	0.423000													77	172					0	0	1	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140730107	140730107	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:140730107G>A	ENST00000523390.1	+	1	280	c.280G>A	c.(280-282)Gga>Aga	p.G94R	PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAGATTTGCGGAAGGAAACT	0.423000											OREG0016856	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	5					0	0	1	0	0
MKNK1	8569	broad.mit.edu	37	1	47037739	47037739	+	Silent	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:47037739G>C	ENST00000371946.4	-	7	652	c.489C>G	c.(487-489)acC>acG	p.T163T	MKNK1_ENST00000371945.4_Silent_p.T163T|MKNK1_ENST00000428112.2_Silent_p.T163T|MKNK1_ENST00000341183.5_Silent_p.T163T|MKNK1_ENST00000371944.4_Silent_p.T68T	NM_003684.5	NP_003675.2	Q9BUB5	MKNK1_HUMAN	MAP kinase interacting serine/threonine kinase 1	163	Protein kinase.				intracellular protein kinase cascade|peptidyl-serine phosphorylation|regulation of translation	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(1)	13	Acute lymphoblastic leukemia(166;0.155)					GTTCACCTTTGGTATGCAGGA	0.592000													20	68					0	0	1	0	0
IBTK	25998	broad.mit.edu	37	6	82901516	82901516	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:82901516T>A	ENST00000306270.7	-	24	3968	c.3419A>T	c.(3418-3420)aAg>aTg	p.K1140M	IBTK_ENST00000503631.1_Missense_Mutation_p.K939M|IBTK_ENST00000510291.1_Missense_Mutation_p.K1125M	NM_015525.2	NP_056340.2	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton agammaglobulinemia tyrosine kinase	1140					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		TAAATGTGACTTTGGTGTAGC	0.358000													10	11					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44061185	44061185	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:44061185G>C	ENST00000344290.5	+	6	1337	c.1015G>C	c.(1015-1017)Ggc>Cgc	p.G339R	MAPT_ENST00000420682.2_Intron|MAPT_ENST00000415613.2_Missense_Mutation_p.G339R|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000347967.5_Intron|MAPT_ENST00000340799.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000262410.5_Missense_Mutation_p.G339R|MAPT_ENST00000571987.1_Missense_Mutation_p.G339R|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000576518.1_Intron|MAPT_ENST00000574436.1_Intron|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000431008.3_Intron	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	339					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				AGAGGCCCGGGGCCCCTCTTT	0.652000													24	28					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539519	56539519	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:56539519C>T	ENST00000390649.3	+	7	1920	c.1920C>T	c.(1918-1920)ctC>ctT	p.L640L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	640						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGTTTGGCCTCGTGAGCGAAG	0.557000													22	9					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50318468	50318468	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:50318468G>T	ENST00000404971.1	-	20	5170	c.3831C>A	c.(3829-3831)taC>taA	p.Y1277*	NRXN1_ENST00000406859.3_Nonsense_Mutation_p.Y1237*|NRXN1_ENST00000342183.5_Nonsense_Mutation_p.Y202*|NRXN1_ENST00000401710.1_Nonsense_Mutation_p.Y255*|NRXN1_ENST00000402717.3_Nonsense_Mutation_p.Y1229*|NRXN1_ENST00000406316.2_Nonsense_Mutation_p.Y1237*|NRXN1_ENST00000405472.3_Nonsense_Mutation_p.Y1229*|NRXN1_ENST00000401669.2_Nonsense_Mutation_p.Y1237*	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1237	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TACCTGCAGGGTAGCGCTCGA	0.448000													122	205					1.22264e-62	1.84323e-62	1	1	0
NUDT17	200035	broad.mit.edu	37	1	145587382	145587382	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:145587382C>A	ENST00000334513.5	-	6	709	c.698G>T	c.(697-699)gGa>gTa	p.G233V		NM_001012758.2	NP_001012776.1	P0C025	NUD17_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 17	233	Nudix hydrolase.						hydrolase activity|metal ion binding			endometrium(3)|large_intestine(1)|lung(2)|skin(1)|urinary_tract(2)	9	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGGGAGAAGTCCGGGTGTCTC	0.537000													58	73					4.96213e-28	6.64959e-28	1	1	0
EMC10	284361	broad.mit.edu	37	19	50983931	50983931	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:50983931G>T	ENST00000376918.3	+	5	542	c.496G>T	c.(496-498)Ggg>Tgg	p.G166W	CTD-2545M3.2_ENST00000598194.1_RNA|EMC10_ENST00000598585.1_Missense_Mutation_p.G166W|EMC10_ENST00000334976.6_Missense_Mutation_p.G166W	NM_175063.4	NP_778233.4			ER membrane protein complex subunit 10																		GACGCACCCCGGGGGCTGCCG	0.697000													7	5					0.27861	0.27861	1	1	0
PCDHA5	56143	broad.mit.edu	37	5	140203730	140203730	+	Silent	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:140203730A>G	ENST00000378126.3	+	1	2370	c.2370A>G	c.(2368-2370)ttA>ttG	p.L790L	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_031501.1	NP_113689.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTAATATTAACATCCATCT	0.398000													4	36					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363782	22363782	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:22363782A>G	ENST00000397121.2	-	3	1054	c.737T>C	c.(736-738)aTt>aCt	p.I246T		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	246					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCCAGTATGAATTATCTTATG	0.363000													19	66					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83673935	83673935	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:83673935A>T	ENST00000398309.2	-	9	1488	c.1018T>A	c.(1018-1020)Tac>Aac	p.Y340N	DLG2_ENST00000376104.2_Missense_Mutation_p.Y445N|DLG2_ENST00000418306.2_Missense_Mutation_p.Y289N|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000280241.8_Missense_Mutation_p.Y379N|DLG2_ENST00000543673.1_Missense_Mutation_p.Y445N|DLG2_ENST00000537455.1_Missense_Mutation_p.Y94N|DLG2_ENST00000532653.1_Missense_Mutation_p.Y340N|DLG2_ENST00000330014.6_Missense_Mutation_p.Y279N|DLG2_ENST00000398301.2_Missense_Mutation_p.Y379N|DLG2_ENST00000531015.1_Missense_Mutation_p.Y307N|DLG2_ENST00000524982.1_Missense_Mutation_p.Y340N	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	340						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				GACCTGGTGTAGTCGTCGTCA	0.428000													32	178					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495407	20495407	+	RNA	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:20495407G>A	ENST00000555186.1	+	0	610					NR_038836.1																						TTCTGTGTGAGGAAAATGAAT	0.393000													10	65					0	0	1	0	0
VWA7	80737	broad.mit.edu	37	6	31741102	31741102	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:31741102G>A	ENST00000375686.3	-	6	1071	c.834C>T	c.(832-834)ctC>ctT	p.L278L	VWA7_ENST00000375688.4_Silent_p.L278L|VWA7_ENST00000467576.1_Intron|VWA7_ENST00000447450.1_Silent_p.L278L	NM_025258.2	NP_079534.2	Q9Y334	G7C_HUMAN	von Willebrand factor A domain containing 7	278						extracellular region											TTGCAGCCTGGAGGTGCAGCA	0.627000													13	10					0	0	1	0	0
TP53TG3D	729264	broad.mit.edu	37	16	32265036	32265036	+	Splice_Site	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:32265036G>T	ENST00000398664.3	+	1	997	c.362_splice	c.e1+1	p.S121_splice	TP53TG3D_ENST00000569631.1_Intron|RP11-56L13.7_ENST00000562604.1_RNA|TP53TG3D_ENST00000354614.3_Splice_Site_p.R121_splice	NM_001243722.1	NP_001230651.1			TP53 target 3D																		GGGTTGTCAAGGTAACGCTCC	0.602000													23	66					1.64293e-13	1.91195e-13	1	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801605	185801605	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:185801605G>T	ENST00000302277.6	+	4	2076	c.1482G>T	c.(1480-1482)atG>atT	p.M494I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	494						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						ACATTTGCATGGGACCACTTT	0.353000													88	72					5.94134e-38	8.41514e-38	1	1	0
ZC3H12C	85463	broad.mit.edu	37	11	110036212	110036212	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:110036212A>G	ENST00000453089.2	+	5	3190	c.2309A>G	c.(2308-2310)cAg>cGg	p.Q770R	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.Q801R|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.Q802R			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	801							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		AACTCCACACAGCCGTGTTAT	0.587000													46	34					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1965176	1965176	+	Splice_Site	SNP	A	A	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:1965176A>C	ENST00000382722.5	-	22	2515		c.e22+1		CACNA2D4_ENST00000588077.1_Splice_Site|CACNA2D4_ENST00000587995.1_Splice_Site|CACNA2D4_ENST00000586184.1_Splice_Site|CACNA2D4_ENST00000585708.1_Splice_Site|CACNA2D4_ENST00000585732.1_Splice_Site|CACNA2D4_ENST00000539048.2_Splice_Site	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4							integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GCCAGCACTCACACTCCAGGT	0.602000													5	64					0	0	1	0	0
PRTG	283659	broad.mit.edu	37	15	55929461	55929461	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:55929461C>G	ENST00000389286.4	-	15	2577	c.2530G>C	c.(2530-2532)Gat>Cat	p.D844H		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	844	Fibronectin type-III 5.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TCTGGGCCATCAGGGGGTTTC	0.478000													85	140					0	0	1	0	0
ORAOV1	220064	broad.mit.edu	37	11	69482327	69482327	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:69482327T>C	ENST00000279147.4	-	5	481	c.374A>G	c.(373-375)gAc>gGc	p.D125G	ORAOV1_ENST00000536870.1_Missense_Mutation_p.D66G|ORAOV1_ENST00000539414.1_3'UTR|ORAOV1_ENST00000535657.1_Missense_Mutation_p.D125G	NM_153451.2	NP_703152.1	Q8WV07	ORAV1_HUMAN	oral cancer overexpressed 1	125										NS(1)|endometrium(1)|large_intestine(2)|lung(1)	5	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;5.64e-57)|all cancers(3;5.98e-51)|BRCA - Breast invasive adenocarcinoma(2;5.49e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			AATTTTAAAGTCTGGCTGAAC	0.373000													15	127					0	0	1	0	0
PODN	127435	broad.mit.edu	37	1	53544070	53544070	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:53544070C>T	ENST00000371500.3	+	10	1316	c.975C>T	c.(973-975)tcC>tcT	p.S325S	RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000312553.5_Silent_p.S344S|PODN_ENST00000395871.2_Silent_p.S202S	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	296					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						tggatctgtccagcaaCAACC	0.607000													35	99					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23713493	23713493	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:23713493C>A	ENST00000256797.4	-	11	1495	c.1327G>T	c.(1327-1329)Gcc>Tcc	p.A443S	ERN2_ENST00000457008.2_Missense_Mutation_p.A395S	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	395					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AAGGCTGGGGCCTGGGTATTC	0.617000													69	113					1.92865e-43	2.83248e-43	1	1	0
HECW2	57520	broad.mit.edu	37	2	197183882	197183882	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:197183882T>C	ENST00000260983.2	-	9	1914	c.1732A>G	c.(1732-1734)Agt>Ggt	p.S578G	HECW2_ENST00000409111.1_Missense_Mutation_p.S222G	NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	578					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCTGCGCCACTTGTGGGCTGA	0.612000													22	53					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060447	35060447	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:35060447G>A	ENST00000373913.3	+	3	807	c.327G>A	c.(325-327)gaG>gaA	p.E109E	DLGAP4_ENST00000401952.2_Silent_p.E109E|DLGAP4_ENST00000373907.2_Silent_p.E109E|DLGAP4_ENST00000339266.5_Silent_p.E109E			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	109					cell-cell signaling	membrane	protein binding	p.E109D(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				ACCAGTTTGAGAAGCAGCTGC	0.647000													4	137					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57061902	57061902	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:57061902T>G	ENST00000301318.3	+	7	897	c.826T>G	c.(826-828)Tta>Gta	p.L276V	ZFP28_ENST00000591844.1_Missense_Mutation_p.L276V|AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	276	KRAB 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		TAAGCCAGATTTAGTCTCTTT	0.468000													39	11					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193081900	193081900	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:193081900G>T	ENST00000342358.4	-	2	350	c.233C>A	c.(232-234)aCa>aAa	p.T78K		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	78					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ACGCACTGTTGTCCTCAGCAA	0.498000													9	173					0.00448238	0.00456263	1	1	0
GPR174	84636	broad.mit.edu	37	X	78427206	78427206	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:78427206C>T	ENST00000276077.1	+	1	738	c.702C>T	c.(700-702)acC>acT	p.T234T		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	234						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						TGATTCTAACCTGTGCAGGGG	0.398000										HNSCC(63;0.18)			53	12					0	0	1	0	0
GPR32	2854	broad.mit.edu	37	19	51274894	51274894	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:51274894C>T	ENST00000270590.4	+	1	1174	c.1037C>T	c.(1036-1038)tCa>tTa	p.S346L		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	346						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GAGTTTCTGTCATCCTGTCCC	0.532000													45	46					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131520083	131520083	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:131520083C>T	ENST00000423981.1	+	2	548	c.438C>T	c.(436-438)atC>atT	p.I146I	AMER3_ENST00000321420.4_Silent_p.I146I	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CCAAGAGCATCCCGAGGAAGA	0.607000													16	61					0	0	1	0	0
NCOA1	8648	broad.mit.edu	37	2	24916208	24916208	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:24916208A>G	ENST00000405141.1	+	11	1511	c.800A>G	c.(799-801)gAt>gGt	p.D267G	NCOA1_ENST00000348332.3_Missense_Mutation_p.D267G|NCOA1_ENST00000407230.1_Missense_Mutation_p.D116G|NCOA1_ENST00000538539.1_Missense_Mutation_p.D267G|NCOA1_ENST00000288599.5_Missense_Mutation_p.D267G|NCOA1_ENST00000406961.1_Missense_Mutation_p.D267G|NCOA1_ENST00000395856.3_Missense_Mutation_p.D267G			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	267									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACCAAGCAAGATACTACAGGT	0.383000			T	PAX3	alveolar rhadomyosarcoma								25	131					0	0	1	0	0
MFRP	83552	broad.mit.edu	37	11	119215633	119215633	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:119215633C>A	ENST00000555262.1	-	6	882	c.723G>T	c.(721-723)gtG>gtT	p.V241V	C1QTNF5_ENST00000445041.2_5'UTR|MFRP_ENST00000530681.1_Silent_p.V241V|MFRP_ENST00000529147.1_Intron|MFRP_ENST00000360167.4_Silent_p.V241V|MFRP_ENST00000449574.2_Silent_p.V241V	NM_001278431.1	NP_001265360.1			membrane frizzled-related protein											autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)|urinary_tract(1)	18		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.84e-05)		CAAATCCTTCCACACTGCTGT	0.597000													25	6					7.92952e-12	8.91511e-12	1	1	0
LINC00969	440993	broad.mit.edu	37	3	195410689	195410689	+	RNA	SNP	C	C	T	rs6583275	by1000genomes	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:195410689C>T	ENST00000445430.1	+	0	1886																											CTTTGAGGTGCACTGGAGGAA	0.567000													5	35					0	0	1	0	0
LELP1	149018	broad.mit.edu	37	1	153177226	153177226	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:153177226G>T	ENST00000368747.1	+	2	153	c.43G>T	c.(43-45)Gag>Tag	p.E15*		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	15										NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CCCCAAGACTGAGCCCAAGAA	0.448000													58	123					9.53615e-21	1.21647e-20	1	1	0
SYNPO2	171024	broad.mit.edu	37	4	119952278	119952278	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:119952278G>T	ENST00000307142.4	+	4	2544	c.2348G>T	c.(2347-2349)gGa>gTa	p.G783V	SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Missense_Mutation_p.G783V|SYNPO2_ENST00000429713.2_Missense_Mutation_p.G783V	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	783	Pro-rich.					nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TGGTCTCCAGGAGTGGCTCCC	0.557000													48	100					1.08114e-33	1.48891e-33	1	1	0
MAP3K19	80122	broad.mit.edu	37	2	135743890	135743890	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:135743890G>T	ENST00000375845.3	-	7	2582	c.2552C>A	c.(2551-2553)cCt>cAt	p.P851H	MAP3K19_ENST00000358371.4_Missense_Mutation_p.P738H|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000315513.3_5'UTR|MAP3K19_ENST00000392915.1_Missense_Mutation_p.P868H|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000392918.3_Intron	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		GTCTTCTGAAGGGATAAATGG	0.418000													42	46					6.61955e-31	9.05354e-31	1	1	0
DPP6	1804	broad.mit.edu	37	7	154585853	154585853	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:154585853C>A	ENST00000404039.1	+	11	1596	c.1009C>A	c.(1009-1011)Cgg>Agg	p.R337R	DPP6_ENST00000427557.1_Silent_p.R294R|DPP6_ENST00000377770.3_Silent_p.R401R|DPP6_ENST00000332007.3_Silent_p.R339R	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	401					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CTGGCTGAACCGGGCGCAGAA	0.632000													17	18					1.55469e-16	1.9039e-16	1	1	0
RBBP6	5930	broad.mit.edu	37	16	24580271	24580271	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:24580271C>T	ENST00000319715.4	+	17	2692	c.2260C>T	c.(2260-2262)Cat>Tat	p.H754Y	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Missense_Mutation_p.H720Y	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	754					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		TCATGGATATCATCGATCTAG	0.493000													21	87					0	0	1	0	0
AKR7L	246181	broad.mit.edu	37	1	19595799	19595799	+	RNA	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:19595799A>G	ENST00000420396.2	-	0	507				AKR7L_ENST00000429712.1_RNA					aldo-keto reductase family 7-like											breast(1)|endometrium(2)|ovary(1)|prostate(1)|urinary_tract(1)	6						CTGAGTCCCAAAGAAGCGGCC	0.597000													30	34					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94732176	94732176	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:94732176A>T	ENST00000304338.3	+	22	2484	c.2330A>T	c.(2329-2331)aAt>aTt	p.N777I		NM_058237.1	NP_478144.1	Q6NUP7	PP4R4_HUMAN	protein phosphatase 4, regulatory subunit 4	777						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						CAGTCTTTTAATAATCAAGCT	0.333000													65	21					0	0	1	0	0
MUS81	80198	broad.mit.edu	37	11	65629734	65629734	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:65629734C>A	ENST00000308110.4	+	5	852	c.503C>A	c.(502-504)gCt>gAt	p.A168D	MUS81_ENST00000533035.1_Missense_Mutation_p.A93D	NM_025128.4	NP_079404.3	Q96NY9	MUS81_HUMAN	MUS81 structure-specific endonuclease subunit	168	Interaction with BLM.				DNA recombination|DNA repair	nucleolus	3'-flap endonuclease activity|DNA binding|metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)|skin(1)	13				READ - Rectum adenocarcinoma(159;0.166)		CAGAGGTGTGCTCAGAAGTCC	0.572000								Homologous recombination					12	75					4.36969e-10	4.85792e-10	1	1	0
MST1L	11223	broad.mit.edu	37	1	17085189	17085189	+	RNA	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:17085189A>G	ENST00000455405.2	-	0	87																		p.S428P(1)									TCCAGGATTGATGGCGGCTGG	0.572000													4	36					0	0	1	0	0
RAPGEF5	9771	broad.mit.edu	37	7	22190105	22190105	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:22190105G>C	ENST00000344041.6	-	18	1657	c.1345C>G	c.(1345-1347)Cca>Gca	p.P449A	RAPGEF5_ENST00000401957.2_Missense_Mutation_p.P299A	NM_012294.3	NP_036426.3	Q92565	RPGF5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 5	299	Ras-GEF.				nervous system development|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	nucleus	GTP-dependent protein binding|Rap guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)|ovary(1)	6						AAGTCATTTGGCTGAAGTTCA	0.388000													48	57					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	41978682	41978682	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:41978682C>A	ENST00000372584.1	-	7	7224	c.6210G>T	c.(6208-6210)agG>agT	p.R2070S	HIVEP3_ENST00000429157.2_Missense_Mutation_p.R2070S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.R2070S|HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000247584.5_Missense_Mutation_p.R2070S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	2070	6 X 4 AA tandem repeats of S-P-X-[RK].				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GAGACCATCTCCTGGTGGGCG	0.687000													29	12					1.57351e-24	2.08753e-24	1	1	0
MAPKBP1	23005	broad.mit.edu	37	15	42115799	42115799	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:42115799G>C	ENST00000457542.2	+	29	4039	c.3753G>C	c.(3751-3753)aaG>aaC	p.K1251N	MAPKBP1_ENST00000260357.7_Missense_Mutation_p.K1090N|MAPKBP1_ENST00000514566.1_Intron|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.K1257N|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.K1134N	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	1257										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		CCATGGCCAAGATATCCCGCA	0.612000													22	52					0	0	1	0	0
XPO7	23039	broad.mit.edu	37	8	21846522	21846522	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:21846522A>T	ENST00000434536.1	+	16	1925	c.1823A>T	c.(1822-1824)aAc>aTc	p.N608I	XPO7_ENST00000252512.9_Missense_Mutation_p.N599I|XPO7_ENST00000433566.4_Missense_Mutation_p.N600I			Q9UIA9	XPO7_HUMAN	exportin 7	599					mRNA transport|protein export from nucleus|transmembrane transport	cytoplasm|nuclear pore	nuclear export signal receptor activity|protein transporter activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				Colorectal(74;0.0187)|COAD - Colon adenocarcinoma(73;0.0724)		AGCATCACCAACTTGAAGTAC	0.433000													29	5					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27223044	27223044	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:27223044C>T	ENST00000230582.3	+	12	1510	c.1495C>T	c.(1495-1497)Cag>Tag	p.Q499*	PRSS16_ENST00000421826.2_Nonsense_Mutation_p.Q242*|PRSS16_ENST00000377456.2_3'UTR	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	499					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CCAGCAGCTACAGACCTGGCT	0.488000													11	13					0	0	1	0	0
LOC440040	440040	broad.mit.edu	37	11	49831437	49831437	+	RNA	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:49831437A>G	ENST00000527477.1	+	0	1662																											GGGTGCTCAGACTTTCACCTC	0.458000													23	39					0	0	1	0	0
TPD52L1	7164	broad.mit.edu	37	6	125569527	125569527	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:125569527G>A	ENST00000534000.1	+	4	680	c.384G>A	c.(382-384)atG>atA	p.M128I	TPD52L1_ENST00000527711.1_Missense_Mutation_p.M128I|TPD52L1_ENST00000528193.1_Missense_Mutation_p.M128I|TPD52L1_ENST00000534199.1_Missense_Mutation_p.M99I|TPD52L1_ENST00000368402.5_Missense_Mutation_p.M128I|TPD52L1_ENST00000304877.13_Missense_Mutation_p.M128I|TPD52L1_ENST00000524679.1_Missense_Mutation_p.M99I|TPD52L1_ENST00000532429.1_Missense_Mutation_p.M99I|TPD52L1_ENST00000530868.1_3'UTR|TPD52L1_ENST00000368388.2_Missense_Mutation_p.M128I|TPD52L1_ENST00000392482.2_Missense_Mutation_p.M99I	NM_003287.2	NP_003278.1	Q16890	TPD53_HUMAN	tumor protein D52-like 1	128					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|large_intestine(2)|prostate(1)	5			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		TCGGAGACATGAGGTACTGTG	0.483000													17	9					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77779485	77779485	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:77779485G>A	ENST00000407578.2	-	26	4015	c.3749C>T	c.(3748-3750)tCa>tTa	p.S1250L	MYCBP2_ENST00000357337.6_Missense_Mutation_p.S1212L|MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Missense_Mutation_p.S1212L	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	1212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		AGCTTCTACTGAATGGGCAGA	0.358000													26	18					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36673144	36673144	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:36673144G>T	ENST00000399881.3	+	9	971	c.934G>T	c.(934-936)Gtg>Ttg	p.V312L		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	312						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		ACCTGAAATGGTGGAACTGTT	0.299000													57	6					9.68594e-22	1.25162e-21	1	1	0
TRIM48	79097	broad.mit.edu	37	11	55032731	55032731	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:55032731T>C	ENST00000417545.2	+	2	486	c.400T>C	c.(400-402)Tct>Cct	p.S134P		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	118						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GTGCTCCAGCTCTCAGGAGCA	0.507000													16	100					0	0	1	0	0
CTSD	1509	broad.mit.edu	37	11	1775105	1775105	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:1775105G>A	ENST00000427721.1	-	5	610	c.611C>T	c.(610-612)cCa>cTa	p.P204L	CTSD_ENST00000236671.2_Silent_p.S333S																							CGGGCAGGGTGGACACCTTCT	0.642000													41	22					0	0	1	0	0
OR5A1	219982	broad.mit.edu	37	11	59211538	59211538	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:59211538G>C	ENST00000302030.2	+	1	922	c.897G>C	c.(895-897)gaG>gaC	p.E299D		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	299					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E299D(1)		central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						GGAACAAAGAGATCAAGGATG	0.433000													80	138					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179641932	179641932	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:179641932G>T	ENST00000589042.1	-	27	4982	c.4758C>A	c.(4756-4758)gaC>gaA	p.D1586E	TTN_ENST00000591111.1_Missense_Mutation_p.D1586E|TTN_ENST00000342992.6_Missense_Mutation_p.D1586E|TTN_ENST00000342175.6_Missense_Mutation_p.D1540E|RP11-88L24.4_ENST00000582038.2_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D1540E|TTN_ENST00000360870.5_Missense_Mutation_p.D1586E|TTN_ENST00000359218.5_Missense_Mutation_p.D1540E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1321	Ig-like 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCATACAATGTCAGGGTTGG	0.358000													42	124					2.27781e-18	2.83303e-18	1	1	0
LOC150776	150776	broad.mit.edu	37	2	132276728	132276728	+	RNA	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:132276728G>T	ENST00000438378.2	+	0	2048					NR_026922.1																						CTCATGGCTGGGCTTTAGCTC	0.597000													21	85					4.87955e-14	5.7288e-14	1	1	0
SFN	2810	broad.mit.edu	37	1	27190105	27190105	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:27190105G>A	ENST00000339276.4	+	1	473	c.402G>A	c.(400-402)gtG>gtA	p.V134V		NM_006142.3	NP_006133.1	P31947	1433S_HUMAN	stratifin	134					DNA damage response, signal transduction resulting in induction of apoptosis|negative regulation of caspase activity|release of cytochrome c from mitochondria	cytoplasm|extracellular space|nucleus	protein domain specific binding|protein kinase C inhibitor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(2)	9		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.1e-52)|Epithelial(14;2.31e-52)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000501)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)|GBM - Glioblastoma multiforme(114;0.0767)|Lung(427;0.215)		TGGCCGAGGTGGCCACCGGTG	0.622000													18	56					0	0	1	0	0
TMEM74B	55321	broad.mit.edu	37	20	1162210	1162210	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:1162210T>A	ENST00000381894.3	-	2	724	c.53A>T	c.(52-54)gAg>gTg	p.E18V	TMEM74B_ENST00000481747.1_5'UTR	NM_018354.1	NP_060824.1	Q9NUR3	CT046_HUMAN	transmembrane protein 74B	18						integral to membrane	protein binding										GGGCCCCAGCTCATCCCTTGG	0.562000													16	32					0	0	1	0	0
WT1	7490	broad.mit.edu	37	11	32410625	32410625	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:32410625G>T	ENST00000332351.3	-	10	1817	c.1533C>A	c.(1531-1533)acC>acA	p.T511T	WT1_ENST00000530998.1_Silent_p.T282T|WT1_ENST00000448076.3_Silent_p.T508T|WT1_ENST00000379079.2_Silent_p.T296T	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	443					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding		EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			GCTGGAGTTTGGTCATGTTTC	0.532000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				36	66					1.15505e-17	1.42325e-17	1	1	0
FLG	2312	broad.mit.edu	37	1	152278724	152278724	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:152278724C>A	ENST00000368799.1	-	3	8673	c.8638G>T	c.(8638-8640)Ggg>Tgg	p.G2880W	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2880	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCCTGGACCCCTCTGATTGT	0.582000									Ichthyosis				63	425					1.16775e-40	1.68393e-40	1	1	0
SYTL2	54843	broad.mit.edu	37	11	85437291	85437291	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:85437291T>A	ENST00000359152.5	-	1	1780	c.1781A>T	c.(1780-1782)gAg>gTg	p.E594V	SYTL2_ENST00000316356.4_Intron|SYTL2_ENST00000525423.1_Missense_Mutation_p.E70V|SYTL2_ENST00000354566.3_Missense_Mutation_p.E70V|SYTL2_ENST00000528231.1_Intron|SYTL2_ENST00000527523.1_Intron|SYTL2_ENST00000524452.1_Intron|SYTL2_ENST00000389960.4_Intron	NM_206928.2	NP_996811.1	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	106	Ser-rich.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TAGAAGCACCTCTGCTTCATG	0.378000													120	56					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70513691	70513691	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:70513691T>A	ENST00000265872.6	+	11	1320	c.1201T>A	c.(1201-1203)Tgg>Agg	p.W401R	CCAR1_ENST00000535016.1_Missense_Mutation_p.W386R|CCAR1_ENST00000543719.1_Missense_Mutation_p.W386R	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	401					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						TCAATTTACATGGGTGGATGC	0.373000													61	26					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178585817	178585817	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:178585817A>T	ENST00000251582.7	-	6	1140	c.1039T>A	c.(1039-1041)Tac>Aac	p.Y347N	ADAMTS2_ENST00000274609.5_Missense_Mutation_p.Y347N	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	347	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		TGCTGGAGGTAGGCCCAGCGG	0.592000													40	20					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11091334	11091334	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:11091334A>G	ENST00000403050.3	+	14	2860	c.2408A>G	c.(2407-2409)cAg>cGg	p.Q803R	PHF14_ENST00000445996.2_Missense_Mutation_p.Q518R	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	803							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		TCAAGGAGGCAGATTAAGGAA	0.453000													18	31					0	0	1	0	0
SLC17A3	10786	broad.mit.edu	37	6	25861887	25861887	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:25861887T>A	ENST00000397060.4	-	5	699	c.590A>T	c.(589-591)cAa>cTa	p.Q197L	SLC17A3_ENST00000361703.6_Missense_Mutation_p.Q119L|SLC17A3_ENST00000360657.3_Missense_Mutation_p.Q119L	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	119					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						GCTTCGTTCTTGTGGAGGGCC	0.423000													16	74					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	663068	663068	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:663068C>G	ENST00000266383.5	+	14	1992	c.1979C>G	c.(1978-1980)tCt>tGt	p.S660C		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	660						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			TGTAACACATCTGGCAACCTG	0.557000													100	50					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													3	68					0	0	1	0	0
LRRC71	149499	broad.mit.edu	37	1	156897534	156897534	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:156897534C>T	ENST00000337428.7	+	8	986	c.832C>T	c.(832-834)Ctg>Ttg	p.L278L	LRRC71_ENST00000490146.1_3'UTR	NM_144702.2	NP_653303.2	Q8N4P6	LRC71_HUMAN	leucine rich repeat containing 71	278										endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|stomach(1)	12						GGGCCTCCGGCTGAACCGTTC	0.701000											OREG0013892	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	49					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175323591	175323591	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:175323591C>A	ENST00000367674.1	-	18	4026	c.3318G>T	c.(3316-3318)acG>acT	p.T1106T	TNR_ENST00000263525.2_Silent_p.T1106T	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1106	Fibronectin type-III 9.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GCAGGAGCACCGTGTAGTCTG	0.557000													59	16					8.81991e-31	1.20217e-30	1	1	0
DRC1	92749	broad.mit.edu	37	2	26667616	26667616	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:26667616G>A	ENST00000288710.2	+	10	1270	c.1196G>A	c.(1195-1197)tGg>tAg	p.W399*	DRC1_ENST00000483675.1_3'UTR	NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		GAGAAGTTTTGGGAGATTTGG	0.527000													12	31					0	0	1	0	0
GPR139	124274	broad.mit.edu	37	16	20043464	20043464	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:20043464G>C	ENST00000570682.1	-	2	955	c.655C>G	c.(655-657)Cgt>Ggt	p.R219G		NM_001002911.2	NP_001002911.1	Q6DWJ6	GP139_HUMAN	G protein-coupled receptor 139	219						integral to membrane|plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	30						GAGTAGCCACGGAGACGAAAA	0.512000													55	87					0	0	1	0	0
LRP5	4041	broad.mit.edu	37	11	68213965	68213965	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:68213965A>T	ENST00000294304.7	+	22	4656	c.4550A>T	c.(4549-4551)tAc>tTc	p.Y1517F		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	1517	Pro-rich.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GACATGTTCTACTCTTCAAAC	0.632000													154	62					0	0	1	0	0
ZBTB20	26137	broad.mit.edu	37	3	114070281	114070281	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:114070281G>C	ENST00000462705.1	-	11	1246	c.425C>G	c.(424-426)aCt>aGt	p.T142S	ZBTB20_ENST00000474710.1_Missense_Mutation_p.T215S|ZBTB20_ENST00000464560.1_Missense_Mutation_p.T142S|ZBTB20_ENST00000393785.2_Missense_Mutation_p.T142S|ZBTB20_ENST00000357258.3_Missense_Mutation_p.T142S|ZBTB20_ENST00000471418.1_Missense_Mutation_p.T142S|ZBTB20_ENST00000481632.1_Missense_Mutation_p.T142S	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	215	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		TGACTCGGGAGTGCCCCGCGG	0.637000													106	24					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75437007	75437007	+	Nonsense_Mutation	SNP	G	G	A	rs143215099		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:75437007G>A	ENST00000549446.1	-	5	2475	c.1795C>T	c.(1795-1797)Cga>Tga	p.R599*	KCNC2_ENST00000341669.3_Intron|KCNC2_ENST00000548513.1_Intron|KCNC2_ENST00000550433.1_Intron|KCNC2_ENST00000350228.2_Intron|KCNC2_ENST00000540018.1_Nonsense_Mutation_p.R544*|RP11-81K13.1_ENST00000547040.1_RNA|RP11-81K13.1_ENST00000550049.1_RNA|KCNC2_ENST00000298972.1_Intron	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	599					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						TTTAAGCTTCGGGATTTTTCA	0.438000													13	25					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176671858	176671858	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:176671858G>T	ENST00000367662.3	+	9	4516	c.3352G>T	c.(3352-3354)Ggg>Tgg	p.G1118W		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1118					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTGTGGAGATGGGAAGGTGTC	0.502000													11	54					4.68919e-08	5.04405e-08	1	1	0
HIST1H2BD	3017	broad.mit.edu	37	6	26158661	26158661	+	Silent	SNP	G	G	C	rs143992438		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr6:26158661G>C	ENST00000289316.2	+	1	288	c.264G>C	c.(262-264)tcG>tcC	p.S88S	HIST1H2BD_ENST00000377777.4_Silent_p.S88S	NM_138720.2	NP_619790.1	P58876	H2B1D_HUMAN	histone cluster 1, H2bd	88					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	24						ACAAGCGCTCGACCATCACCT	0.622000													51	92					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91699439	91699439	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:91699439G>A	ENST00000359028.2	+	28	6687	c.6462G>A	c.(6460-6462)agG>agA	p.R2154R	AKAP9_ENST00000356239.3_Silent_p.R2142R|AKAP9_ENST00000358100.2_Silent_p.R2154R			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2154	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TACAAGAAAGGAATGAAGAAA	0.393000			T	BRAF	papillary thyroid								30	62					0	0	1	0	0
CSNK2A1	1457	broad.mit.edu	37	20	476447	476447	+	Splice_Site	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:476447C>A	ENST00000217244.3	-	8	802		c.e8-1		CSNK2A1_ENST00000400227.3_Splice_Site|CSNK2A1_ENST00000460062.1_Splice_Site|CSNK2A1_ENST00000400217.1_Splice_Site|CSNK2A1_ENST00000349736.5_Splice_Site	NM_177559.2	NP_808227.1	P68400	CSK21_HUMAN	casein kinase 2, alpha 1 polypeptide						axon guidance|Wnt receptor signaling pathway	cytosol|NuRD complex|plasma membrane|Sin3 complex	ATP binding|protein N-terminus binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|urinary_tract(1)	17		Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.0969)			AATCCAGGGCCTGTGGGATGA	0.433000													41	32					6.4771e-29	8.76832e-29	1	1	0
UBA1	7317	broad.mit.edu	37	X	47061801	47061801	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:47061801G>T	ENST00000335972.6	+	10	1137	c.954G>T	c.(952-954)acG>acT	p.T318T	UBA1_ENST00000377351.4_Silent_p.T318T	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	318	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TTGTGGTGACGGACTTCGCCA	0.592000													25	7					9.78306e-22	1.26008e-21	1	1	0
REG1A	5967	broad.mit.edu	37	2	79349999	79349999	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:79349999G>A	ENST00000233735.1	+	5	457	c.354G>A	c.(352-354)ctG>ctA	p.L118L		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	118	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GTGGGTCCCTGGTCTCCTACA	0.562000													54	125					0	0	1	0	0
GJC2	57165	broad.mit.edu	37	1	228345508	228345508	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:228345508C>A	ENST00000366714.2	+	2	224	c.49C>A	c.(49-51)Cac>Aac	p.H17N		NM_020435.3	NP_065168.2	Q5T442	CXG2_HUMAN	gap junction protein, gamma 2, 47kDa	17					cell death	connexon complex|integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	7		Prostate(94;0.0405)				GGAGGAGATCCACAACCACTC	0.672000													9	1					4.68919e-08	5.04405e-08	1	1	0
ABCA9	10350	broad.mit.edu	37	17	67045515	67045515	+	Silent	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:67045515A>G	ENST00000340001.4	-	3	424	c.213T>C	c.(211-213)ttT>ttC	p.F71F	ABCA9_ENST00000453985.2_Silent_p.F71F|ABCA9_ENST00000495634.1_Silent_p.F71F|ABCA9_ENST00000370732.2_Silent_p.F71F	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9	71					transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					TAGTATCATTAAAACTATCTA	0.368000													43	63					0	0	1	0	0
PHKG2	5261	broad.mit.edu	37	16	30767819	30767819	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:30767819G>A	ENST00000563588.1	+	8	1018	c.779G>A	c.(778-780)cGt>cAt	p.R260H	PHKG2_ENST00000424889.3_Missense_Mutation_p.R260H|PHKG2_ENST00000328273.7_Missense_Mutation_p.R264H	NM_000294.2	NP_000285.1	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	260	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)|skin(1)	2			Colorectal(24;0.198)			TGGGATGACCGTTCCAGCACT	0.617000													3	52					0	0	1	0	0
ZNF827	152485	broad.mit.edu	37	4	146813419	146813419	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:146813419C>T	ENST00000508784.1	-	3	1469	c.1242G>A	c.(1240-1242)aaG>aaA	p.K414K	ZNF827_ENST00000513320.1_Silent_p.K64K|ZNF827_ENST00000379448.4_Silent_p.K414K			Q17R98	ZN827_HUMAN	zinc finger protein 827	414					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	all_hematologic(180;0.151)					TGAGATTGTCCTTGCGAGCAC	0.517000													25	101					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158142839	158142839	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:158142839G>T	ENST00000296526.7	+	2	434	c.109G>T	c.(109-111)Gcc>Tcc	p.A37S	GRIA2_ENST00000264426.9_Missense_Mutation_p.A37S|GRIA2_ENST00000507898.1_5'UTR|GRIA2_ENST00000393815.2_5'UTR|GRIA2_ENST00000449365.1_5'UTR|GRIA2_ENST00000504801.1_Intron	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	37					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TCCTAGGGGCGCCGATCAAGA	0.542000													57	18					3.07184e-27	4.10266e-27	1	1	0
CCDC40	55036	broad.mit.edu	37	17	78069164	78069164	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:78069164C>A	ENST00000397545.4	+	18	2962	c.2935C>A	c.(2935-2937)Cgc>Agc	p.R979S		NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	979					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			CGAGGGGCAGCGCAAGATGGA	0.642000													21	44					1.64293e-13	1.91195e-13	1	1	0
LCN1	3933	broad.mit.edu	37	9	138413373	138413373	+	Silent	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr9:138413373T>C	ENST00000263598.2	+	1	90	c.30T>C	c.(28-30)ctT>ctC	p.L10L	LCN1_ENST00000371781.3_Silent_p.L10L	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	10					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity	p.L10L(2)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		CCGTCAGCCTTGGCCTCATTG	0.667000													4	35					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175118	143175118	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:143175118G>A	ENST00000408916.1	+	1	153	c.153G>A	c.(151-153)ttG>ttA	p.L51L	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	51					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					TCATTAGCTTGGGTGCCTCCC	0.572000													83	89					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53069036	53069036	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:53069036A>T	ENST00000252244.3	-	9	1934	c.1876T>A	c.(1876-1878)Tct>Act	p.S626T		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	626	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CTGCCACCAGAGGACTTGACA	0.612000													28	71					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60904863	60904863	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:60904863C>T	ENST00000252999.3	-	32	4155	c.4089G>A	c.(4087-4089)gtG>gtA	p.V1363V		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1363	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGGCACACGCACGGTCACAG	0.622000													13	38					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33635130	33635130	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:33635130G>T	ENST00000380099.3	+	4	1922	c.1914G>T	c.(1912-1914)tgG>tgT	p.W638C	KL_ENST00000487852.1_3'UTR|KL_ENST00000426690.2_3'UTR	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	638	Glycosyl hydrolase-1 2.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		TGGCCCTGTGGCAGCCTATGG	0.637000													49	16					1.86277e-20	2.36863e-20	1	1	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89917074	89917074	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:89917074C>A	ENST00000548729.1	-	3	1546	c.1244G>T	c.(1243-1245)cGg>cTg	p.R415L	POC1B-GALNT4_ENST00000413530.1_Missense_Mutation_p.R246L|POC1B-GALNT4_ENST00000547474.1_3'UTR|POC1B_ENST00000393179.4_Intron|GALNT4_ENST00000529983.2_Missense_Mutation_p.R418L|POC1B_ENST00000541909.1_Intron|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000313546.3_Intron|POC1B_ENST00000549035.1_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					GCATCTCAACCGCTCTCGTAG	0.403000													21	35					2.52088e-20	3.18511e-20	1	1	0
TAS2R16	50833	broad.mit.edu	37	7	122635314	122635314	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:122635314C>T	ENST00000249284.2	-	1	440	c.375G>A	c.(373-375)ttG>ttA	p.L125L		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	125					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						TCCAGGGAAACAACCTCAAAA	0.418000													28	14					0	0	1	0	0
CCAR1	55749	broad.mit.edu	37	10	70513692	70513692	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:70513692G>T	ENST00000265872.6	+	11	1321	c.1202G>T	c.(1201-1203)tGg>tTg	p.W401L	CCAR1_ENST00000535016.1_Missense_Mutation_p.W386L|CCAR1_ENST00000543719.1_Missense_Mutation_p.W386L	NM_018237.2	NP_060707.2	Q8IX12	CCAR1_HUMAN	cell division cycle and apoptosis regulator 1	401					apoptosis|cell cycle|nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm|perinuclear region of cytoplasm	calcium ion binding|nucleic acid binding|protein binding	p.W401L(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|lung(13)|ovary(7)|skin(3)	56						CAATTTACATGGGTGGATGCT	0.373000													62	26					1.17004e-41	1.70578e-41	1	1	0
KLHDC8A	55220	broad.mit.edu	37	1	205308387	205308387	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:205308387C>G	ENST00000367156.3	-	7	1508	c.692G>C	c.(691-693)cGg>cCg	p.R231P	KLHDC8A_ENST00000460687.1_Missense_Mutation_p.R97P|KLHDC8A_ENST00000367155.3_Missense_Mutation_p.R231P|KLHDC8A_ENST00000537168.1_Missense_Mutation_p.R118P|KLHDC8A_ENST00000539253.1_Missense_Mutation_p.R231P	NM_001271863.1	NP_001258792.1	Q8IYD2	KLD8A_HUMAN	kelch domain containing 8A	231										breast(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	14	Breast(84;0.23)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCGACCTTGCCGCAGGCCTCC	0.592000													36	12					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49227631	49227631	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:49227631T>C	ENST00000340334.7	-	3	535	c.167A>G	c.(166-168)aAg>aGg	p.K56R	FOLH1_ENST00000343844.4_5'UTR|FOLH1_ENST00000356696.3_Missense_Mutation_p.K71R|FOLH1_ENST00000533034.1_Missense_Mutation_p.K56R|FOLH1_ENST00000256999.2_Missense_Mutation_p.K71R	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	71					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	TAAGAACTTCTTGATGTTCTC	0.303000													28	57					0	0	1	0	0
FSD1	79187	broad.mit.edu	37	19	4318437	4318437	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:4318437G>T	ENST00000221856.6	+	9	1041	c.894G>T	c.(892-894)caG>caT	p.Q298H	FSD1_ENST00000597590.1_Missense_Mutation_p.Q298H|FSD1_ENST00000598010.1_3'UTR	NM_024333.2	NP_077309.1	Q9BTV5	FSD1_HUMAN	fibronectin type III and SPRY domain containing 1	298	B30.2/SPRY.				cell division|mitosis	cleavage furrow|microtubule|microtubule organizing center|nucleus				breast(2)|cervix(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.034)|STAD - Stomach adenocarcinoma(1328;0.18)		GGAAGGTGCAGGATATCAAGG	0.632000													23	12					5.52252e-06	5.79937e-06	1	1	0
SMPD4	55627	broad.mit.edu	37	2	130931133	130931133	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:130931133C>A	ENST00000409031.1	-	4	1488	c.340G>T	c.(340-342)Gtg>Ttg	p.V114L	SMPD4_ENST00000426662.2_Intron|SMPD4_ENST00000351288.6_Missense_Mutation_p.V114L|SMPD4_ENST00000431183.2_Intron|SMPD4_ENST00000473720.1_Intron|SMPD4_ENST00000443958.2_Intron|SMPD4_ENST00000452225.2_Intron|SMPD4_ENST00000453750.1_Intron|SMPD4_ENST00000339679.7_Missense_Mutation_p.R26L	NM_017951.4	NP_060421.2	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)	75					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(17)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	ACAGGATTCACGCGCCCCTGT	0.552000													11	48					2.27111e-07	2.42333e-07	1	1	0
KCNC2	3747	broad.mit.edu	37	12	75444377	75444377	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:75444377G>C	ENST00000549446.1	-	3	2088	c.1408C>G	c.(1408-1410)Cct>Gct	p.P470A	KCNC2_ENST00000548243.1_5'UTR|KCNC2_ENST00000341669.3_Missense_Mutation_p.P470A|KCNC2_ENST00000548513.1_Missense_Mutation_p.P470A|KCNC2_ENST00000393288.2_Missense_Mutation_p.P470A|KCNC2_ENST00000550433.1_Missense_Mutation_p.P470A|KCNC2_ENST00000350228.2_Missense_Mutation_p.P470A|KCNC2_ENST00000540018.1_Missense_Mutation_p.P470A|KCNC2_ENST00000298972.1_Missense_Mutation_p.P470A	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	470					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						ACAATGACAGGCACTGGCATG	0.507000													11	14					0	0	1	0	0
STRN	6801	broad.mit.edu	37	2	37152290	37152290	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:37152290A>T	ENST00000263918.4	-	2	304	c.296T>A	c.(295-297)gTg>gAg	p.V99E	STRN_ENST00000379213.2_Missense_Mutation_p.V87E	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	99					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GATCCTCCTCACAAGATCCTT	0.393000													7	157					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24537702	24537702	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:24537702C>T	ENST00000264463.4	-	3	820	c.313G>A	c.(313-315)Gat>Aat	p.D105N		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	105	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.D105H(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GTTTTTTCATCAATAATAAAA	0.378000										HNSCC(23;0.051)			23	47					0	0	1	0	0
RAP2B	5912	broad.mit.edu	37	3	152880659	152880659	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:152880659G>A	ENST00000323534.2	+	1	631	c.177G>A	c.(175-177)gcG>gcA	p.A59A		NM_002886.2	NP_002877.2	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family	59					Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TGGATACGGCGGGCACCGAGC	0.587000													106	32					0	0	1	0	0
TTC6	319089	broad.mit.edu	37	14	38281595	38281595	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:38281595G>A	ENST00000553443.1	+	25	4646	c.4646G>A	c.(4645-4647)gGa>gAa	p.G1549E	TTC6_ENST00000476979.1_Missense_Mutation_p.G183E|TTC6_ENST00000382320.3_Missense_Mutation_p.G263E|TTC6_ENST00000267368.7_Missense_Mutation_p.G183E					tetratricopeptide repeat domain 6											central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	14	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;1.59e-06)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0543)|all cancers(34;0.108)|BRCA - Breast invasive adenocarcinoma(188;0.156)|LUSC - Lung squamous cell carcinoma(13;0.176)	GBM - Glioblastoma multiforme(112;0.00551)		CTTAATCGTGGACTCATCTAC	0.378000													61	186					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113519663	113519663	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:113519663G>A	ENST00000284601.3	-	4	1552	c.1484C>T	c.(1483-1485)gCa>gTa	p.A495V		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	495					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TTTGAGACATGCCGACGTATC	0.333000													16	21					0	0	1	0	0
HSPA13	6782	broad.mit.edu	37	21	15746400	15746400	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr21:15746400C>G	ENST00000285667.3	-	5	1021	c.954G>C	c.(952-954)agG>agC	p.R318S	HSPA13_ENST00000544452.1_Missense_Mutation_p.R110S	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	318						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						GAGGTTCCTTCCTGTCCTGCT	0.458000													35	29					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24835027	24835027	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:24835027G>T	ENST00000395799.3	+	25	5917	c.5788G>T	c.(5788-5790)Ggt>Tgt	p.G1930C	TNRC6A_ENST00000432286.2_Missense_Mutation_p.G408C|TNRC6A_ENST00000315183.7_Missense_Mutation_p.G1881C	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1930	Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		AAGCCTGTGGGGTCCCCCAAG	0.567000													81	104					2.24395e-52	3.34492e-52	1	1	0
PCDH15	65217	broad.mit.edu	37	10	55569237	55569237	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:55569237C>T	ENST00000395445.1	-	36	4967	c.4573G>A	c.(4573-4575)Gta>Ata	p.V1525I	PCDH15_ENST00000395446.1_Missense_Mutation_p.V721I|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395440.1_Missense_Mutation_p.V459I|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000395442.1_Missense_Mutation_p.V390I	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TCGATAGTTACAACTACTTCT	0.378000										HNSCC(58;0.16)			35	61					0	0	1	0	0
KCNA4	3739	broad.mit.edu	37	11	30033924	30033924	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr11:30033924C>A	ENST00000328224.6	-	2	1535	c.302G>T	c.(301-303)aGc>aTc	p.S101I		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	101						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						ATGAGGGAAGCTGCTCTGCCG	0.612000													27	42					1.26454e-06	1.33853e-06	1	1	0
EIF4G3	8672	broad.mit.edu	37	1	21133930	21133930	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:21133930T>C	ENST00000602326.1	-	35	5241	c.4658A>G	c.(4657-4659)tAc>tGc	p.Y1553C	EIF4G3_ENST00000537738.1_Missense_Mutation_p.Y1037C|EIF4G3_ENST00000264211.8_Missense_Mutation_p.Y1547C|EIF4G3_ENST00000400422.1_Missense_Mutation_p.Y1547C|EIF4G3_ENST00000374935.3_Missense_Mutation_p.Y1267C|EIF4G3_ENST00000374937.3_Missense_Mutation_p.Y1553C|EIF4G3_ENST00000536266.1_Missense_Mutation_p.Y1151C	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1547	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CTCCCATTTGTAGAAGGCATC	0.498000													231	118					0	0	1	0	0
CCDC178	374864	broad.mit.edu	37	18	30926280	30926280	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr18:30926280C>A	ENST00000383096.3	-	9	735	c.553G>T	c.(553-555)Gaa>Taa	p.E185*	CCDC178_ENST00000583930.1_Nonsense_Mutation_p.E185*|CCDC178_ENST00000403303.1_Nonsense_Mutation_p.E185*|CCDC178_ENST00000402325.1_Nonsense_Mutation_p.E185*|CCDC178_ENST00000300227.8_Nonsense_Mutation_p.E185*|CCDC178_ENST00000579916.1_Intron|CCDC178_ENST00000579947.1_Nonsense_Mutation_p.E185*|CCDC178_ENST00000406524.2_Nonsense_Mutation_p.E185*					coiled-coil domain containing 178																		AAAGCTTCTTCAGCGTCTGCC	0.398000													37	51					2.04263e-09	2.24577e-09	1	1	0
C16orf93	90835	broad.mit.edu	37	16	30770380	30770380	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:30770380G>A	ENST00000543610.1	-	8	1731	c.770C>T	c.(769-771)cCg>cTg	p.P257L	C16orf93_ENST00000541260.1_Missense_Mutation_p.P322L|PHKG2_ENST00000563588.1_3'UTR|PHKG2_ENST00000424889.3_Intron	NM_001014979.2	NP_001014979.2	A1A4V9	CP093_HUMAN	chromosome 16 open reading frame 93	257										breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(6)	11						CTCTTTCTGCGGGGTAACTGC	0.597000													58	207					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109098746	109098746	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:109098746G>A	ENST00000309863.6	+	11	3898	c.3184G>A	c.(3184-3186)Gaa>Aaa	p.E1062K		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1062					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						ATTTCAGTGTGAAACAATAAA	0.328000													20	62					0	0	1	0	0
ITCH	83737	broad.mit.edu	37	20	33028041	33028041	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:33028041C>G	ENST00000374864.4	+	9	974	c.761C>G	c.(760-762)aCa>aGa	p.T254R	ITCH_ENST00000535650.1_Missense_Mutation_p.T144R|ITCH_ENST00000262650.6_Missense_Mutation_p.T295R	NM_001257137.1|NM_001257138.1|NM_031483.5	NP_001244066.1|NP_001244067.1|NP_113671.3	Q96J02	ITCH_HUMAN	itchy E3 ubiquitin protein ligase	295	Arg/Pro-rich (PRR domain).				apoptosis|entry of virus into host cell|inflammatory response|innate immune response|negative regulation of apoptosis|negative regulation of defense response to virus|negative regulation of JNK cascade|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cell growth|regulation of protein deubiquitination|response to virus	cytosol|nucleus|plasma membrane	CXCR chemokine receptor binding|ribonucleoprotein binding|ubiquitin-protein ligase activity			NS(1)|breast(9)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(13)|skin(1)|upper_aerodigestive_tract(1)	36						AATACAAATACAAATACATCT	0.433000													61	37					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13901660	13901660	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:13901660T>C	ENST00000265104.4	-	14	1857	c.1753A>G	c.(1753-1755)Att>Gtt	p.I585V		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	585	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGTCATCAATACCAAGATTA	0.289000									Kartagener syndrome				22	24					0	0	1	0	0
STARD3NL	83930	broad.mit.edu	37	7	38254007	38254007	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:38254007A>T	ENST00000009041.7	+	3	532	c.275A>T	c.(274-276)gAc>gTc	p.D92V	STARD3NL_ENST00000544203.1_Missense_Mutation_p.D85V|STARD3NL_ENST00000434197.1_Missense_Mutation_p.D92V|STARD3NL_ENST00000396013.1_Missense_Mutation_p.D92V	NM_032016.3	NP_114405.1	O95772	MENTO_HUMAN	STARD3 N-terminal like	92	MENTAL.					integral to membrane|late endosome membrane				endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	10						ATGCAGTATGACTACTATTCT	0.338000													36	77					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171440	207171440	+	Missense_Mutation	SNP	A	A	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:207171440A>C	ENST00000374423.3	+	5	2574	c.2188A>C	c.(2188-2190)Aat>Cat	p.N730H		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	730							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GGATGAAGTAAATCTTAAAGA	0.413000													31	72					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26885835	26885835	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:26885835G>T	ENST00000231021.4	-	11	1942	c.1770C>A	c.(1768-1770)gcC>gcA	p.A590A		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	590	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GATTATCGCAGGCACACACAC	0.488000													18	14					8.34094e-07	8.85251e-07	1	1	0
BMP3	651	broad.mit.edu	37	4	81952498	81952498	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:81952498G>T	ENST00000282701.2	+	1	380	c.60G>T	c.(58-60)gcG>gcT	p.A20A		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	20					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						TGAGCCTGGCGCAGGGAGAGA	0.701000													13	16					0.000308642	0.000318237	1	1	0
CDX2	1045	broad.mit.edu	37	13	28542988	28542988	+	Silent	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:28542988T>A	ENST00000381020.7	-	1	2288	c.156A>T	c.(154-156)gcA>gcT	p.A52A		NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	52	Poly-Ala.			AA -> Q (in Ref. 2; AAB40603).	organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CCAAGTTCGCTGCCGCTGCAG	0.726000			T	ETV6	AML								2	3					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460300	107460300	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:107460300A>G	ENST00000409382.3	-	2	744	c.134T>C	c.(133-135)tTc>tCc	p.F45S	ST6GAL2_ENST00000409087.3_Missense_Mutation_p.F45S|ST6GAL2_ENST00000361686.4_Missense_Mutation_p.F45S	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	45					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GGTCTCCAGGAAGGAGAGGGA	0.627000													5	8					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401209	89401209	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:89401209A>G	ENST00000439576.2	+	12	5767	c.5393A>G	c.(5392-5394)cAg>cGg	p.Q1798R	ACAN_ENST00000561243.1_Missense_Mutation_p.Q1798R|ACAN_ENST00000352105.7_Missense_Mutation_p.Q1798R|ACAN_ENST00000559004.1_Missense_Mutation_p.Q1798R	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1798					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CTCAGTGGGCAGCCTTCAGGG	0.507000													13	26					0	0	1	0	0
GLB1	2720	broad.mit.edu	37	3	33055583	33055583	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:33055583G>A	ENST00000307363.5	-	15	1843	c.1699C>T	c.(1699-1701)Cag>Tag	p.Q567*	GLB1_ENST00000307377.8_Nonsense_Mutation_p.Q436*|GLB1_ENST00000399402.3_Nonsense_Mutation_p.Q537*|GLB1_ENST00000445488.2_Nonsense_Mutation_p.Q615*	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	567					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				AAGGTGTCCTGGGGCAAGTCT	0.502000													43	13					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87199537	87199537	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:87199537C>G	ENST00000265724.3	-	6	706	c.289G>C	c.(289-291)Gat>Cat	p.D97H	ABCB1_ENST00000543898.1_Missense_Mutation_p.D97H	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	97	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TCATTGATATCACCTAGACCA	0.303000													65	86					0	0	1	0	0
ANKRD36	375248	broad.mit.edu	37	2	97869965	97869965	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:97869965C>G	ENST00000420699.2	+	50	3270	c.3026C>G	c.(3025-3027)gCc>gGc	p.A1009G	ANKRD36_ENST00000461153.2_Missense_Mutation_p.A1009G	NM_001164315.1	NP_001157787.1	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1009										endometrium(9)|kidney(5)|liver(1)|lung(3)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	23						TTGAATATAGCCAGAGGAAAA	0.308000													4	5					0	0	1	0	0
GABRB3	2562	broad.mit.edu	37	15	26866525	26866525	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:26866525C>A	ENST00000541819.2	-	5	667	c.565G>T	c.(565-567)Gga>Tga	p.G189*	GABRB3_ENST00000400188.3_Nonsense_Mutation_p.G62*|GABRB3_ENST00000299267.4_Nonsense_Mutation_p.G133*|GABRB3_ENST00000311550.5_Nonsense_Mutation_p.G133*|GABRB3_ENST00000545868.1_Nonsense_Mutation_p.G48*			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	133					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	ACTGTCACTCCATGCACAAAT	0.493000													49	102					2.6711e-34	3.69131e-34	1	1	0
GPR158	57512	broad.mit.edu	37	10	25464537	25464537	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr10:25464537G>C	ENST00000376351.3	+	1	547	c.188G>C	c.(187-189)cGc>cCc	p.R63P	GPR158-AS1_ENST00000449643.1_RNA	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	63						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						CCCTGGAGCCGCTCCACCGAT	0.682000													30	25					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168114105	168114105	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:168114105C>A	ENST00000519560.1	-	30	3612	c.3193G>T	c.(3193-3195)Ggc>Tgc	p.G1065C	SLIT3_ENST00000332966.8_Missense_Mutation_p.G1072C|SLIT3_ENST00000404867.3_Missense_Mutation_p.G1065C	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1065	EGF-like 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCGCTGTAGCCAGGGACACAC	0.602000													34	12					6.57855e-14	7.70077e-14	1	1	0
OR4K5	79317	broad.mit.edu	37	14	20388777	20388777	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:20388777C>A	ENST00000315915.4	+	1	37	c.12C>A	c.(10-12)tcC>tcA	p.S4S		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGGATAAGTCCAATTCTTCAG	0.348000													33	114					5.37117e-13	6.1784e-13	1	1	0
PPP1R21	129285	broad.mit.edu	37	2	48687258	48687258	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:48687258G>T	ENST00000294952.8	+	6	722	c.565G>T	c.(565-567)Gaa>Taa	p.E189*	PPP1R21_ENST00000449090.2_Nonsense_Mutation_p.E189*|PPP1R21_ENST00000281394.4_Nonsense_Mutation_p.E189*	NM_001135629.2	NP_001129101.1	Q6ZMI0	KLRAQ_HUMAN	protein phosphatase 1, regulatory subunit 21	189										endometrium(2)|kidney(4)|lung(9)	15						TCTAGAAAAGGAAGCCAAGGA	0.438000													11	30					6.81908e-15	8.15013e-15	1	1	0
UGT2B28	54490	broad.mit.edu	37	4	70146303	70146303	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:70146303T>A	ENST00000335568.5	+	1	87	c.85T>A	c.(85-87)Tgg>Agg	p.W29R	UGT2B28_ENST00000511240.1_Missense_Mutation_p.W29R	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	29					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	GGTGCTGGTGTGGACCGGTGA	0.468000													151	29					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113235478	113235478	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:113235478G>A	ENST00000369644.1	+	8	1928	c.899G>A	c.(898-900)cGg>cAg	p.R300Q	MOV10_ENST00000413052.2_Missense_Mutation_p.R356Q|MOV10_ENST00000369645.1_Missense_Mutation_p.R356Q|MOV10_ENST00000357443.2_Missense_Mutation_p.R356Q|MOV10_ENST00000468624.1_3'UTR			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	356					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CATGATATCCGGCACTATGAC	0.607000													20	10					0	0	1	0	0
LINC00969	440993	broad.mit.edu	37	3	195410687	195410687	+	RNA	SNP	T	T	A	rs6583274	by1000genomes	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:195410687T>A	ENST00000445430.1	+	0	1884																											CCCTTTGAGGTGCACTGGAGG	0.567000													4	35					0	0	1	0	0
NPHP4	261734	broad.mit.edu	37	1	5967264	5967264	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:5967264C>A	ENST00000378156.4	-	13	1787	c.1522G>T	c.(1522-1524)Gcg>Tcg	p.A508S	NPHP4_ENST00000478423.2_Intron	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	508					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GGGGAGGCCGCCAGCTGGGAA	0.632000													3	10					0.004672	0.00474351	1	1	0
FAM126A	84668	broad.mit.edu	37	7	23016318	23016318	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:23016318T>C	ENST00000432176.2	-	6	756	c.524A>G	c.(523-525)cAg>cGg	p.Q175R	FAM126A_ENST00000409923.1_Missense_Mutation_p.Q175R	NM_032581.3	NP_115970.2	Q9BYI3	HYCCI_HUMAN	family with sequence similarity 126, member A	175						cytoplasm|membrane	signal transducer activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|urinary_tract(2)	23						ATACCGATTCTGTGCTGTCAG	0.373000													52	75					0	0	1	0	0
MTRR	4552	broad.mit.edu	37	5	7892968	7892968	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:7892968T>C	ENST00000264668.2	+	11	1610	c.1580T>C	c.(1579-1581)gTt>gCt	p.V527A	MTRR_ENST00000440940.2_Missense_Mutation_p.V500A	NM_002454.2|NM_024010.2	NP_002445.2|NP_076915.2	Q9UBK8	MTRR_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	527	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(14)|ovary(1)|prostate(3)|stomach(1)	31					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GTTGCTTCAGTTCTTCAGCCA	0.458000													32	34					0	0	1	0	0
CDH2	1000	broad.mit.edu	37	18	25583079	25583079	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr18:25583079T>C	ENST00000269141.3	-	7	1325	c.902A>G	c.(901-903)aAt>aGt	p.N301S	CDH2_ENST00000399380.3_Missense_Mutation_p.N270S	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	301	Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CAACATCCCATTGAGGGCATT	0.458000													41	75					0	0	1	0	0
SDR39U1	56948	broad.mit.edu	37	14	24911632	24911632	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:24911632C>G	ENST00000399395.3	-	2	76	c.43G>C	c.(43-45)Gcc>Ccc	p.A15P	SDR39U1_ENST00000554698.1_5'UTR|SDR39U1_ENST00000553930.1_5'UTR|SDR39U1_ENST00000555365.1_5'UTR|SDR39U1_ENST00000538105.2_5'UTR	NM_020195.2	NP_064580.2	Q9NRG7	D39U1_HUMAN	short chain dehydrogenase/reductase family 39U, member 1	0							binding			NS(1)|central_nervous_system(1)|large_intestine(2)|pancreas(1)	5						TGGGTTAGGGCTGTCCCAATG	0.602000													4	13					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81627150	81627150	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:81627150C>G	ENST00000548058.1	+	13	2529	c.1619C>G	c.(1618-1620)gCt>gGt	p.A540G	ACSS3_ENST00000548324.1_Missense_Mutation_p.A222G|ACSS3_ENST00000261206.3_Missense_Mutation_p.A539G			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	540						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						ACCATGGATGCTGGTTACATG	0.348000													31	64					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32595879	32595879	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr21:32595879T>A	ENST00000286827.3	-	9	2309	c.1838A>T	c.(1837-1839)cAg>cTg	p.Q613L	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Missense_Mutation_p.Q613L	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	613					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CATTTGGAACTGCTCGAGATT	0.438000													40	57					0	0	1	0	0
TAS2R41	259287	broad.mit.edu	37	7	143175119	143175119	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:143175119G>T	ENST00000408916.1	+	1	154	c.154G>T	c.(154-156)Ggt>Tgt	p.G52C	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	52					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					CATTAGCTTGGGTGCCTCCCG	0.572000													83	90					8.34767e-46	1.23969e-45	1	1	0
IGHV1OR15-9	390531	broad.mit.edu	37	15	20169986	20169986	+	RNA	SNP	C	C	A	rs143332200	by1000genomes	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:20169986C>A	ENST00000338912.5	-	0	285																											TAGGCTGTGCCCATGGATGTG	0.522000													104	143					2.5327e-61	3.80383e-61	1	1	0
RELN	5649	broad.mit.edu	37	7	103270586	103270586	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:103270586A>T	ENST00000424685.2	-	20	2662	c.2503T>A	c.(2503-2505)Ttt>Att	p.F835I	RELN_ENST00000343529.5_Missense_Mutation_p.F835I|RELN_ENST00000428762.1_Missense_Mutation_p.F835I			P78509	RELN_HUMAN	reelin	835					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGAATTCCAAACTGCTTTGCA	0.338000													47	76					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57287713	57287713	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:57287713G>T	ENST00000543872.2	+	2	565	c.301G>T	c.(301-303)Gag>Tag	p.E101*	SMG8_ENST00000300917.5_Nonsense_Mutation_p.E101*|SMG8_ENST00000580498.1_Intron|SMG8_ENST00000578922.1_Nonsense_Mutation_p.E101*|CTD-2510F5.6_ENST00000577660.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	101					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						CGCCGTGGGTGAGGCCGGTGG	0.632000													13	16					1.05317e-09	1.16111e-09	1	1	0
DNAJC10	54431	broad.mit.edu	37	2	183593347	183593347	+	Missense_Mutation	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:183593347T>C	ENST00000264065.6	+	6	878	c.463T>C	c.(463-465)Tcc>Ccc	p.S155P	DNAJC10_ENST00000537515.1_Missense_Mutation_p.S155P|DNAJC10_ENST00000469118.1_3'UTR	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	155	Thioredoxin 1.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			AAATTTTTACTCCCCAGGCTG	0.313000													61	37					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77572051	77572051	+	Missense_Mutation	SNP	G	G	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:77572051G>C	ENST00000461745.1	+	6	1832	c.932G>C	c.(931-933)cGa>cCa	p.R311P	ROBO2_ENST00000332191.8_Missense_Mutation_p.R311P|ROBO2_ENST00000487694.3_Missense_Mutation_p.R327P	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	311					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CTCACCGTCCGAGGTAAGAGA	0.363000													11	55					0	0	1	0	0
LELP1	149018	broad.mit.edu	37	1	153177225	153177225	+	Silent	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:153177225T>C	ENST00000368747.1	+	2	152	c.42T>C	c.(40-42)acT>acC	p.T14T		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	14										NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACCCCAAGACTGAGCCCAAGA	0.448000													59	124					0	0	1	0	0
KBTBD6	89890	broad.mit.edu	37	13	41704875	41704875	+	Silent	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr13:41704875C>T	ENST00000379485.1	-	1	2007	c.1773G>A	c.(1771-1773)agG>agA	p.R591R	KBTBD6_ENST00000499385.2_Silent_p.R525R	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	591							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		ATTGGTCTCCCCTAATATCAT	0.423000													61	27					0	0	1	0	0
CXXC11	285093	broad.mit.edu	37	2	242814603	242814603	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:242814603C>A	ENST00000343216.3	+	2	924	c.896C>A	c.(895-897)cCg>cAg	p.P299Q		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	299						integral to membrane											CTCTGCAGCCCGGTTGGCGTG	0.667000													14	45					7.07596e-05	7.39168e-05	1	1	0
GABRG1	2565	broad.mit.edu	37	4	46043202	46043202	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:46043202C>A	ENST00000295452.4	-	9	1368	c.1201G>T	c.(1201-1203)Gat>Tat	p.D401Y		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	401					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TACCCATAATCATCTTCTTGC	0.418000													13	79					2.61681e-11	2.93378e-11	1	1	0
LILRB5	10990	broad.mit.edu	37	19	54759183	54759183	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:54759183C>A	ENST00000450632.1	-	5	968	c.891G>T	c.(889-891)tcG>tcT	p.S297S	LILRB5_ENST00000449561.2_Silent_p.S306S|LILRB5_ENST00000316219.5_Silent_p.S306S|LILRB5_ENST00000345866.6_Silent_p.S206S			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	306	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CGCTGGGGGCCGACCACCTAG	0.677000													26	15					1.39806e-14	1.66595e-14	1	1	0
DPP6	1804	broad.mit.edu	37	7	154585852	154585852	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:154585852C>A	ENST00000404039.1	+	11	1595	c.1008C>A	c.(1006-1008)aaC>aaA	p.N336K	DPP6_ENST00000427557.1_Missense_Mutation_p.N293K|DPP6_ENST00000377770.3_Missense_Mutation_p.N400K|DPP6_ENST00000332007.3_Missense_Mutation_p.N338K	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	400					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			CCTGGCTGAACCGGGCGCAGA	0.637000													16	18					2.39556e-15	2.8892e-15	1	1	0
CR1	1378	broad.mit.edu	37	1	207793405	207793405	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:207793405C>A	ENST00000367049.4	+	43	7247	c.7247C>A	c.(7246-7248)aCc>aAc	p.T2416N	CR1_ENST00000367051.1_Missense_Mutation_p.T1966N|CR1_ENST00000367052.1_Missense_Mutation_p.T1966N|CR1_ENST00000400960.2_Missense_Mutation_p.T1966N|CR1_ENST00000367053.1_Missense_Mutation_p.T1966N	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1966					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GCCAAATGTACCTCTCGTAAG	0.483000											OREG0014194	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	28					0.000602214	0.000617735	1	1	0
LRRK1	79705	broad.mit.edu	37	15	101569284	101569284	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:101569284T>G	ENST00000284395.5	+	21	3201	c.2801T>G	c.(2800-2802)aTt>aGt	p.I934S	LRRK1_ENST00000388948.3_Missense_Mutation_p.I937S			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	937					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ATCTTTAATATTAAGGGCTCT	0.567000													14	46					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207171010	207171010	+	Silent	SNP	T	T	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:207171010T>C	ENST00000374423.3	+	5	2144	c.1758T>C	c.(1756-1758)gaT>gaC	p.D586D		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	586							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TTGATTGTGATGTTTCTCTTG	0.423000													6	25					0	0	1	0	0
OR4K14	122740	broad.mit.edu	37	14	20482814	20482814	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:20482814C>A	ENST00000305045.2	-	1	538	c.539G>T	c.(538-540)tGt>tTt	p.C180F		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		AGGGAGGTCACAGAAGAAGCT	0.473000													30	45					3.76114e-14	4.44193e-14	1	1	0
SND1	27044	broad.mit.edu	37	7	127725833	127725833	+	Splice_Site	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:127725833G>A	ENST00000354725.3	+	20	2498		c.e20+1			NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1						gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						CTACGGCAACGTGAGTGTTGG	0.517000													28	69					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193036809	193036809	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:193036809C>A	ENST00000342358.4	-	17	2121	c.2004G>T	c.(2002-2004)ggG>ggT	p.G668G		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	668					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		CTGAAAGATTCCCCATCTTTA	0.502000													70	32					2.9551e-36	4.12677e-36	1	1	0
POC1B-GALNT4	100528030	broad.mit.edu	37	12	89917073	89917073	+	Silent	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:89917073C>A	ENST00000548729.1	-	3	1547	c.1245G>T	c.(1243-1245)cgG>cgT	p.R415R	POC1B-GALNT4_ENST00000413530.1_Silent_p.R246R|POC1B-GALNT4_ENST00000547474.1_3'UTR|POC1B_ENST00000393179.4_Intron|GALNT4_ENST00000529983.2_Silent_p.R418R|POC1B_ENST00000541909.1_Intron|POC1B_ENST00000549504.1_Intron|POC1B_ENST00000313546.3_Intron|POC1B_ENST00000549035.1_Intron	NM_001199781.1|NM_001199782.1	NP_001186710.1|NP_001186711.1																					TGCATCTCAACCGCTCTCGTA	0.403000													21	35					2.52088e-20	3.18511e-20	1	1	0
SULT1A2	6799	broad.mit.edu	37	16	28606784	28606784	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:28606784C>T	ENST00000533150.1	-	2	1477	c.361G>A	c.(361-363)Gat>Aat	p.D121N	SULT1A2_ENST00000335715.4_Splice_Site_p.G92_splice|SULT1A2_ENST00000395630.1_Splice_Site_p.G92_splice			P50226	ST1A2_HUMAN	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2	125					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine biosynthetic process|catecholamine metabolic process|steroid metabolic process|sulfation|xenobiotic metabolic process	cytosol	aryl sulfotransferase activity|flavonol 3-sulfotransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(3)|skin(2)	14						GAGTCTCCATCCCTGAGCAGT	0.592000													55	86					0	0	1	0	0
ZMYND12	84217	broad.mit.edu	37	1	42898847	42898847	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:42898847G>A	ENST00000372565.3	-	7	1211	c.942C>T	c.(940-942)gtC>gtT	p.V314V	ZMYND12_ENST00000433602.2_Silent_p.V204V|ZMYND12_ENST00000475426.1_5'UTR	NM_032257.4	NP_115633.3	Q9H0C1	ZMY12_HUMAN	zinc finger, MYND-type containing 12	314						intracellular	zinc ion binding			NS(1)|endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(2)|skin(2)	17	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGTAAAACATGACCAGGATCT	0.378000													37	132					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19359518	19359518	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:19359518G>T	ENST00000252575.5	+	14	3690	c.3647G>T	c.(3646-3648)gGt>gTt	p.G1216V	NCAN_ENST00000538881.1_Missense_Mutation_p.G667V	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1216	Sushi.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GTGCTCTGTGGTCCCCCTCCG	0.517000													4	27					0.00909568	0.0092114	1	1	0
MYBPH	4608	broad.mit.edu	37	1	203138423	203138423	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:203138423G>T	ENST00000255416.4	-	8	1245	c.1188C>A	c.(1186-1188)ggC>ggA	p.G396G		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	396	Ig-like C2-type 2.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		GGGTGCTGTAGCCAGGGGTGG	0.612000													21	5					3.7963e-18	4.70694e-18	1	1	0
TIMD4	91937	broad.mit.edu	37	5	156378792	156378792	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:156378792G>T	ENST00000274532.2	-	3	466	c.410C>A	c.(409-411)aCc>aAc	p.T137N	TIMD4_ENST00000407087.3_Missense_Mutation_p.T137N	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	137	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTGTGCGTGGTTGTTGAGGC	0.483000													191	73					1.13899e-125	1.74353e-125	1	1	0
HMCN1	83872	broad.mit.edu	37	1	185992227	185992227	+	Silent	SNP	A	A	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:185992227A>C	ENST00000271588.4	+	36	5920	c.5691A>C	c.(5689-5691)acA>acC	p.T1897T	HMCN1_ENST00000367492.2_Silent_p.T1897T	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1897	Ig-like C2-type 16.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GCAGATACACATGTGTGGCTA	0.403000													89	15					0	0	1	0	0
DNAAF2	55172	broad.mit.edu	37	14	50101770	50101770	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:50101770C>T	ENST00000298292.8	-	1	178	c.98G>A	c.(97-99)cGg>cAg	p.R33Q	DNAAF2_ENST00000406043.3_Missense_Mutation_p.R33Q	NM_018139.2	NP_060609.2	Q9NVR5	KTU_HUMAN	dynein, axonemal, assembly factor 2	33					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm				kidney(1)|lung(4)	5						GAACATTCGCCGGAACTCCGG	0.677000													7	14					0	0	1	0	0
WNK3	65267	broad.mit.edu	37	X	54228562	54228562	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrX:54228562C>G	ENST00000354646.2	-	23	5373	c.4935G>C	c.(4933-4935)atG>atC	p.M1645I	WNK3_ENST00000375159.2_Missense_Mutation_p.M1645I|WNK3_ENST00000375169.3_Missense_Mutation_p.M1588I	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1588					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						CATCTGTGAACATCCCTTTTT	0.403000													9	4					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179606021	179606021	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:179606021G>T	ENST00000589042.1	-	48	12163	c.11939C>A	c.(11938-11940)aCc>aAc	p.T3980N	TTN_ENST00000591111.1_Missense_Mutation_p.T3663N|TTN_ENST00000342992.6_Intron|TTN_ENST00000342175.6_Missense_Mutation_p.T3809N|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.T3617N|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000582847.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.T3742N	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3663							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAAACACTGGTGCAAAGCTG	0.453000													58	53					6.8682e-38	9.69342e-38	1	1	0
SDK2	54549	broad.mit.edu	37	17	71431739	71431739	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:71431739C>T	ENST00000392650.3	-	9	1045	c.1045G>A	c.(1045-1047)Gtg>Atg	p.V349M	SDK2_ENST00000388726.3_Missense_Mutation_p.V349M	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	349	Ig-like C2-type 4.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TCCACCTCCACCACGGCTGCG	0.667000													5	7					0	0	1	0	0
ITGA11	22801	broad.mit.edu	37	15	68623343	68623343	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:68623343G>T	ENST00000423218.2	-	15	1972	c.1877C>A	c.(1876-1878)gCc>gAc	p.A626D	ITGA11_ENST00000315757.7_Missense_Mutation_p.A626D			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	626					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GTTGCCAAGGGCTCCCACTGC	0.562000													14	22					1.99824e-07	2.14366e-07	1	1	0
B3GALT1	8708	broad.mit.edu	37	2	168726004	168726004	+	Missense_Mutation	SNP	T	T	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:168726004T>A	ENST00000305861.1	+	2	806	c.455T>A	c.(454-456)cTt>cAt	p.L152H	AC016723.4_ENST00000436982.2_RNA|AC016723.4_ENST00000430546.1_RNA|B3GALT1_ENST00000392690.2_Missense_Mutation_p.L152H	NM_020981.3	NP_066191.1	Q9Y5Z6	B3GT1_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	152					lipid glycosylation|protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18						TACCATAACCTTACCCTCAAA	0.423000													32	29					0	0	1	0	0
GDF5	8200	broad.mit.edu	37	20	34025350	34025350	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr20:34025350C>A	ENST00000374372.1	-	3	862	c.359G>T	c.(358-360)cGg>cTg	p.R120L	GDF5_ENST00000374369.3_Missense_Mutation_p.R120L			P43026	GDF5_HUMAN	growth differentiation factor 5	120					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GGTCACAGTCCGGGCTGTAGC	0.632000													18	145					9.7654e-05	0.000101479	1	1	0
NUP188	23511	broad.mit.edu	37	9	131762057	131762057	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr9:131762057G>T	ENST00000372577.2	+	34	3837	c.3816G>T	c.(3814-3816)cgG>cgT	p.R1272R		NM_015354.1	NP_056169.1	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1272					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						ACTGTTCTCGGTCCCGGCACA	0.592000													36	18					2.40228e-13	2.77938e-13	1	1	0
EFTUD1	79631	broad.mit.edu	37	15	82512557	82512557	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:82512557C>T	ENST00000268206.7	-	13	1474	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	EFTUD1_ENST00000359445.3_Missense_Mutation_p.E385K	NM_024580.5	NP_078856.4	Q7Z2Z2	ETUD1_HUMAN	elongation factor Tu GTP binding domain containing 1	436					mature ribosome assembly		GTP binding|GTPase activity|ribosome binding|translation elongation factor activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32						GCAATTTCTTCTTGAGTGAGA	0.502000													10	206					0	0	1	0	0
SATB2	23314	broad.mit.edu	37	2	200213847	200213847	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:200213847C>A	ENST00000443023.1	-	6	2038	c.573G>T	c.(571-573)caG>caT	p.Q191H	SATB2_ENST00000417098.1_Missense_Mutation_p.Q250H|SATB2_ENST00000457245.1_Missense_Mutation_p.Q250H|SATB2_ENST00000260926.5_Missense_Mutation_p.Q250H|SATB2_ENST00000428695.1_Missense_Mutation_p.Q132H			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	250						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GCATTGGACGCTGGCCCAGAA	0.408000													20	27					1.87028e-06	1.97446e-06	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77763391	77763391	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:77763391C>A	ENST00000521891.2	+	10	4682	c.4234C>A	c.(4234-4236)Ctt>Att	p.L1412I	ZFHX4_ENST00000518282.1_Missense_Mutation_p.L1386I|ZFHX4_ENST00000050961.6_Missense_Mutation_p.L1367I|ZFHX4_ENST00000455469.2_Missense_Mutation_p.L1367I	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1367						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TATGCAGAAGCTTCAGATACA	0.438000										HNSCC(33;0.089)			41	8					7.05377e-20	8.88418e-20	1	1	0
TMEM99	147184	broad.mit.edu	37	17	38991250	38991250	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:38991250C>G	ENST00000301665.3	+	3	786	c.482C>G	c.(481-483)gCc>gGc	p.A161G		NM_001195386.1|NM_001195387.1|NM_145274.3	NP_001182315.1|NP_001182316.1|NP_660317.2	Q8N816	TMM99_HUMAN	transmembrane protein 99	161						integral to membrane				cervix(1)|large_intestine(1)|lung(5)|skin(2)|urinary_tract(1)	10		Breast(137;0.000301)				CAATCTCATGCCGGTTGGCAA	0.468000													76	220					0	0	1	0	0
FGF6	2251	broad.mit.edu	37	12	4543450	4543450	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:4543450G>T	ENST00000228837.2	-	3	601	c.558C>A	c.(556-558)taC>taA	p.Y186*		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	186					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			TTACCCGTCCGTATTTGCTCA	0.488000													61	56					2.05175e-36	2.87534e-36	1	1	0
FBXL18	80028	broad.mit.edu	37	7	5521544	5521544	+	Silent	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:5521544G>A	ENST00000382368.3	-	5	2142	c.2019C>T	c.(2017-2019)ccC>ccT	p.P673P		NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	0									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CGTTTAACGCGGGCCGCTCGG	0.632000													41	76					0	0	1	0	0
GFPT1	2673	broad.mit.edu	37	2	69597229	69597229	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:69597229C>T	ENST00000357308.4	-	3	305	c.127G>A	c.(127-129)Gat>Aat	p.D43N	GFPT1_ENST00000361060.4_Missense_Mutation_p.D43N|GFPT1_ENST00000494201.1_5'UTR	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	43	Glutamine amidotransferase type-2.		D -> V (in LGMTA).		dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						TTGCCTCCATCAAATCCCACA	0.328000													66	69					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58785450	58785450	+	Missense_Mutation	SNP	A	A	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:58785450A>T	ENST00000355431.3	+	7	749	c.376A>T	c.(376-378)Aca>Tca	p.T126S	ARID4A_ENST00000348476.3_Missense_Mutation_p.T126S|ARID4A_ENST00000395168.3_Missense_Mutation_p.T126S|ARID4A_ENST00000431317.2_Missense_Mutation_p.T126S	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	126					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						GCTTCCATTAACAAATCCAGA	0.363000													43	18					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136700111	136700111	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:136700111G>T	ENST00000445907.2	+	3	1027	c.499G>T	c.(499-501)Ggg>Tgg	p.G167W	CHRM2_ENST00000402486.3_Missense_Mutation_p.G167W|AC009264.1_ENST00000439694.1_RNA|AC009264.1_ENST00000425981.2_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.G167W|CHRM2_ENST00000453373.1_Missense_Mutation_p.G167W|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.G167W|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000598184.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.G167W|AC009264.1_ENST00000586239.1_RNA	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	167					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GTTCATTGTAGGGGTGAGAAC	0.498000													52	107					2.73361e-28	3.6756e-28	1	1	0
HNRNPLL	92906	broad.mit.edu	37	2	38812888	38812888	+	Silent	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:38812888A>G	ENST00000449105.2	-	3	783	c.444T>C	c.(442-444)tcT>tcC	p.S148S	HNRNPLL_ENST00000410076.1_Silent_p.S143S|HNRNPLL_ENST00000358367.4_Silent_p.S148S|HNRNPLL_ENST00000409636.1_Silent_p.S143S|HNRNPLL_ENST00000409328.1_Silent_p.S148S|HNRNPLL_ENST00000378915.3_Silent_p.S148S	NM_138394.3	NP_612403.2			heterogeneous nuclear ribonucleoprotein L-like																		TTTTGCTTGTAGAATAGTTGA	0.408000													56	70					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132505712	132505712	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:132505712G>T	ENST00000333577.4	+	24	4753	c.4644G>T	c.(4642-4644)ccG>ccT	p.P1548P	EP400_ENST00000332482.4_Silent_p.P1475P|EP400_ENST00000389562.2_Silent_p.P1511P|EP400_ENST00000330386.6_Intron|EP400_ENST00000389561.2_Silent_p.P1512P			Q96L91	EP400_HUMAN	E1A binding protein p400	1548					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCGCTAGCCCGGCCCATCCTG	0.716000													21	59					1.88708e-17	2.31808e-17	1	1	0
IL7R	3575	broad.mit.edu	37	5	35876369	35876369	+	Silent	SNP	C	C	T	rs139678300		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:35876369C>T	ENST00000303115.3	+	8	1290	c.1161C>T	c.(1159-1161)tcC>tcT	p.S387S	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	387					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			CTTCCAGGTCCCTAGACTGCA	0.537000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						36	53					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55732407	55732407	+	Silent	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr16:55732407G>T	ENST00000379906.2	+	10	1671	c.1416G>T	c.(1414-1416)ctG>ctT	p.L472L	SLC6A2_ENST00000561820.1_Silent_p.L472L|SLC6A2_ENST00000414754.3_Silent_p.L472L|SLC6A2_ENST00000219833.8_Silent_p.L472L|SLC6A2_ENST00000567238.1_Silent_p.L367L|SLC6A2_ENST00000568943.1_Silent_p.L472L|SLC6A2_ENST00000566163.1_Silent_p.L427L	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	472					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	TGACCCTCCTGGACACCTTTG	0.512000													17	48					1.37657e-19	1.72287e-19	1	1	0
TET3	200424	broad.mit.edu	37	2	74274030	74274030	+	Missense_Mutation	SNP	C	C	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:74274030C>G	ENST00000409262.3	+	1	581	c.581C>G	c.(580-582)cCc>cGc	p.P194R		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	194							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCAGAGGTGCCCCAGATCTCT	0.647000													24	19					0	0	1	0	0
CSAD	51380	broad.mit.edu	37	12	53566378	53566378	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:53566378G>A	ENST00000267085.4	-	5	495	c.262C>T	c.(262-264)Cgg>Tgg	p.R88W	CSAD_ENST00000491654.1_5'UTR|CSAD_ENST00000444623.1_Missense_Mutation_p.R61W|CSAD_ENST00000379846.1_Intron|CSAD_ENST00000379843.3_Intron|CSAD_ENST00000542115.1_Missense_Mutation_p.R61W|CSAD_ENST00000453446.2_Missense_Mutation_p.R61W	NM_001244706.1|NM_015989.4	NP_001231635.1|NP_057073.4	Q9Y600	CSAD_HUMAN	cysteine sulfinic acid decarboxylase	61					carboxylic acid metabolic process		pyridoxal phosphate binding|sulfinoalanine decarboxylase activity			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(4)	14					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	CCCTGGCTCCGCAGCTCCAAA	0.617000													3	10					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67257396	67257396	+	Missense_Mutation	SNP	G	G	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:67257396G>A	ENST00000392676.3	-	26	3498	c.3434C>T	c.(3433-3435)gCg>gTg	p.A1145V	ABCA5_ENST00000392677.2_Missense_Mutation_p.A1146V|ABCA5_ENST00000588877.1_Missense_Mutation_p.A1145V			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1145					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					ACAAGCCAACGCTGCCTAAAG	0.299000													33	35					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129012520	129012520	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:129012520A>G	ENST00000326639.6	+	7	732	c.521A>G	c.(520-522)tAt>tGt	p.Y174C	LARP1B_ENST00000354456.3_5'UTR|LARP1B_ENST00000264584.5_Missense_Mutation_p.Y127C|LARP1B_ENST00000394288.3_Missense_Mutation_p.Y174C|LARP1B_ENST00000512292.1_Missense_Mutation_p.Y174C|LARP1B_ENST00000432347.2_Missense_Mutation_p.Y174C|LARP1B_ENST00000427266.1_Missense_Mutation_p.Y174C|LARP1B_ENST00000441387.1_Missense_Mutation_p.Y174C	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	174							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						GATTATTCATATGGTTATCAA	0.318000													23	31					0	0	1	0	0
TSHR	7253	broad.mit.edu	37	14	81609871	81609871	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:81609871C>A	ENST00000541158.2	+	11	1791	c.1469C>A	c.(1468-1470)aCa>aAa	p.T490K	TSHR_ENST00000298171.2_Missense_Mutation_p.T490K|RP11-114N19.3_ENST00000557775.1_RNA			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	490					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GACTGGCAGACAGGCCCTGGG	0.547000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						24	9					2.3814e-25	3.16989e-25	1	1	0
CTBP1	1487	broad.mit.edu	37	4	1232119	1232119	+	Missense_Mutation	SNP	C	C	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr4:1232119C>A	ENST00000510568.1	-	2	605	c.14G>T	c.(13-15)cGa>cTa	p.R5L	CTBP1_ENST00000382952.3_Missense_Mutation_p.R5L|CTBP1_ENST00000515690.1_5'UTR|CTBP1_ENST00000290921.6_Missense_Mutation_p.R16L			Q13363	CTBP1_HUMAN	C-terminal binding protein 1	16	Interaction with GLIS2 1 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		GATCGGAGGTCGGACGCCTGC	0.672000													34	63					1.59361e-14	1.88767e-14	1	1	0
MPLKIP	136647	broad.mit.edu	37	7	40172830	40172830	+	Missense_Mutation	SNP	C	C	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:40172830C>T	ENST00000306984.5	-	2	459	c.368G>A	c.(367-369)gGa>gAa	p.G123E		NM_138701.3	NP_619646.1	Q8TAP9	TTDN1_HUMAN	M-phase specific PLK1 interacting protein	123					cell division|mitosis	microtubule organizing center|nucleus											ACGCCCTGATCCAAATGGTGT	0.358000													35	78					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130833055	130833055	+	Missense_Mutation	SNP	T	T	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:130833055T>G	ENST00000357462.5	-	15	2083	c.1990A>C	c.(1990-1992)Aca>Cca	p.T664P	POTEF_ENST00000409914.2_Missense_Mutation_p.T664P|POTEF_ENST00000360967.5_3'UTR|POTEF_ENST00000361163.4_3'UTR			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	664						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TGTTTCATTGTGTCTAGCTCC	0.343000													5	19					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926429	1926429	+	Missense_Mutation	SNP	G	G	T			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:1926429G>T	ENST00000399161.2	-	10	1859	c.1112C>A	c.(1111-1113)aCg>aAg	p.T371K	MYT1L_ENST00000428368.2_Missense_Mutation_p.T371K	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	371					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCTGTCCGGCGTCCTTCCGGG	0.602000													13	12					4.93089e-13	5.68839e-13	1	1	0
MGA	23269	broad.mit.edu	37	15	41988653	41988653	+	Missense_Mutation	SNP	A	A	G			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:41988653A>G	ENST00000219905.7	+	3	1626	c.1445A>G	c.(1444-1446)aAg>aGg	p.K482R	MGA_ENST00000545763.1_Missense_Mutation_p.K482R|MGA_ENST00000566586.1_Missense_Mutation_p.K482R|MGA_ENST00000570161.1_Missense_Mutation_p.K482R|MGA_ENST00000389936.4_Missense_Mutation_p.K482R|MGA_ENST00000568630.1_3'UTR	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	482						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		AGCACAGTTAAGATTTCTGAA	0.408000													31	51					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74575212	74575212	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:74575212delG	ENST00000354431.4	-	5	924	c.733delC	c.(733-735)agfs	p.Q246fs	LRRIQ3_ENST00000468759.1_5'UTR|LRRIQ3_ENST00000395089.1_Frame_Shift_Del_p.Q246fs|LRRIQ3_ENST00000370909.2_Frame_Shift_Del_p.Q138fs	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	246				QQEKII -> TAGKNY (in Ref. 1; BAD18621).						NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTTTCCTGCTGTTTTTTTTTG	0.323													9	51	---	---	---	---					
SPAG17	200162	broad.mit.edu	37	1	118582041	118582041	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:118582041delC	ENST00000336338.5	-	23	3258	c.3193delG	c.(3193-3195)tafs	p.V1065fs		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1065						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TTGTCCTTTACCACTCTCACT	0.388													11	46	---	---	---	---					
FLG2	388698	broad.mit.edu	37	1	152324558	152324559	+	Frame_Shift_Del	DEL	TG	TG	-	rs140875805	byFrequency	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:152324558_152324559delTG	ENST00000388718.5	-	3	5775_5776	c.5703_5704delCA	c.(5701-5706)cagcfs	p.HS1901fs	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1901							calcium ion binding|structural molecule activity	p.H1901fs*30(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGCTTGGCTGTGTGTGTGTC	0.515													7	553	---	---	---	---					
LMNA	4000	broad.mit.edu	37	1	156106935	156106936	+	Frame_Shift_Ins	INS	-	-	C	rs58013325		TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr1:156106935_156106936insC	ENST00000368300.4	+	9	1732_1733	c.1520_1521insC	c.(1519-1521)accfs	p.T507fs	LMNA_ENST00000448611.2_Frame_Shift_Ins_p.T395fs|LMNA_ENST00000473598.2_Frame_Shift_Ins_p.T408fs|LMNA_ENST00000392353.3_Frame_Shift_Ins_p.T426fs|LMNA_ENST00000368297.1_Frame_Shift_Ins_p.T426fs|LMNA_ENST00000368299.3_Frame_Shift_Ins_p.T507fs|LMNA_ENST00000368301.2_Frame_Shift_Ins_p.T507fs|LMNA_ENST00000361308.4_Frame_Shift_Ins_p.T507fs|LMNA_ENST00000347559.2_Frame_Shift_Ins_p.T507fs|LMNA_ENST00000496738.1_3'UTR	NM_170707.3	NP_733821.1	P02545	LMNA_HUMAN	lamin A/C	507	Tail.				cellular component disassembly involved in apoptosis|cellular response to hypoxia|establishment or maintenance of microtubule cytoskeleton polarity|muscle organ development|positive regulation of cell aging|regulation of apoptosis|regulation of cell migration	cytoplasm|lamin filament|nuclear envelope|perinuclear region of cytoplasm	protein binding|structural molecule activity			NS(1)|endometrium(1)|kidney(1)|lung(3)|ovary(4)	10	Hepatocellular(266;0.158)					GCCACCCACAGCCCCCCTACCG	0.634									Werner syndrome;Hutchinson-Gilford Progeria Syndrome				21	26	---	---	---	---					
TPO	7173	broad.mit.edu	37	2	1457501	1457501	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:1457501delT	ENST00000345913.4	+	6	609	c.518delT	c.(517-519)cgfs	p.L173fs	TPO_ENST00000382198.1_Frame_Shift_Del_p.L173fs|TPO_ENST00000349624.3_Frame_Shift_Del_p.L173fs|TPO_ENST00000382201.3_Frame_Shift_Del_p.L173fs|TPO_ENST00000497517.2_Intron|TPO_ENST00000346956.3_Frame_Shift_Del_p.L173fs|TPO_ENST00000337415.3_Frame_Shift_Del_p.L173fs|TPO_ENST00000329066.4_Frame_Shift_Del_p.L173fs	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	173					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AACACGGCCCTGGCACGATGG	0.602													71	130	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168105918	168105918	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr2:168105918delT	ENST00000409195.1	+	9	8105	c.8016delT	c.(8014-8016)gcfs	p.A2672fs	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Del_p.A2450fs|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Frame_Shift_Del_p.A2672fs	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2497					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CCAAATCAGCTTGCGAAATTA	0.403													14	63	---	---	---	---					
PRRT3	285368	broad.mit.edu	37	3	9991858	9991859	+	Splice_Site	INS	-	-	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:9991858_9991859insA	ENST00000412055.1	-	2	73		c.e2-2		PRRT3-AS1_ENST00000431558.1_RNA|PRRT3_ENST00000411976.2_Splice_Site	NM_207351.3	NP_997234.3	Q5FWE3	PRRT3_HUMAN	proline-rich transmembrane protein 3							integral to membrane				NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(1)|skin(1)|stomach(2)	13						TGGATGAGCCTAAAAAAAAAAC	0.574													3	3	---	---	---	---					
ALCAM	214	broad.mit.edu	37	3	105269071	105269071	+	Frame_Shift_Del	DEL	A	A	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr3:105269071delA	ENST00000306107.5	+	12	1975	c.1475delA	c.(1474-1476)ggfs	p.E492fs	ALCAM_ENST00000486979.2_Frame_Shift_Del_p.E441fs|ALCAM_ENST00000389927.4_Frame_Shift_Del_p.E214fs|ALCAM_ENST00000472644.2_Frame_Shift_Del_p.E492fs	NM_001627.3	NP_001618.2	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	492	Ig-like C2-type 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	28						AACCAACTGGAGAGAACAGTA	0.318													43	28	---	---	---	---					
MYO10	4651	broad.mit.edu	37	5	16694605	16694606	+	Frame_Shift_Ins	INS	-	-	C			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:16694605_16694606insC	ENST00000513610.1	-	27	4128_4129	c.3674_3675insG	c.(3673-3675)gtcfs	p.V1225fs	MYO10_ENST00000515803.1_Frame_Shift_Ins_p.V564fs|MYO10_ENST00000274203.9_Frame_Shift_Ins_p.V582fs|MYO10_ENST00000505695.1_Frame_Shift_Ins_p.V564fs|MYO10_ENST00000427430.2_Frame_Shift_Ins_p.V582fs	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1225	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity	p.S1226fs*25(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						GCGTGGAGGAGCCCCCCCCTTT	0.564													7	182	---	---	---	---					
FYB	2533	broad.mit.edu	37	5	39119140	39119141	+	Splice_Site	INS	-	-	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr5:39119140_39119141insA	ENST00000351578.6	-	15	2291		c.e15-2		FYB_ENST00000505428.1_Splice_Site|FYB_ENST00000540520.1_Splice_Site|FYB_ENST00000512982.1_Splice_Site|FYB_ENST00000515010.1_Splice_Site	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein						cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			ACCATCATACTAAAAAAAAAAG	0.272													3	5	---	---	---	---					
CCDC129	223075	broad.mit.edu	37	7	31617539	31617539	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:31617539delG	ENST00000319386.3	+	8	1654	c.661delG	c.(661-663)atfs	p.D221fs	CCDC129_ENST00000409210.1_Frame_Shift_Del_p.D129fs|CCDC129_ENST00000407970.3_Frame_Shift_Del_p.D221fs|CCDC129_ENST00000451887.2_Frame_Shift_Del_p.D247fs			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	221										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TCTGCTGAGTGATGTCAGCAT	0.498													21	30	---	---	---	---					
PAXIP1	22976	broad.mit.edu	37	7	154782739	154782740	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr7:154782739_154782740insA	ENST00000404141.1	-	4	454_455	c.300_301insT	c.(298-303)ttgaatfs	p.LN100fs	PAXIP1_ENST00000397192.1_Frame_Shift_Ins_p.LN100fs|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	100	BRCT 2.|Interaction with PA1 (By similarity).				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GCAGTGATTCCAAAAAAAATCT	0.332													4	9	---	---	---	---					
FAM66D	100132923	broad.mit.edu	37	8	11994626	11994627	+	RNA	DEL	GT	GT	-	rs138516564	by1000genomes	TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr8:11994626_11994627delGT	ENST00000434078.2	+	0	608					NR_027425.1																						gtatttgtgcgtgtgtgtgtgt	0.510													12	169	---	---	---	---					
IGFBP6	3489	broad.mit.edu	37	12	53491528	53491530	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr12:53491528_53491530delGCT	ENST00000548547.1	+	1	309_311	c.27_29delGCT	c.(25-30)ccg>cc	p.PL9del	IGFBP6_ENST00000301464.3_In_Frame_Del_p.PL9del			P24592	IBP6_HUMAN	insulin-like growth factor binding protein 6	9					negative regulation of cell proliferation|regulation of cell growth|signal transduction					large_intestine(1)|lung(3)|ovary(1)|pancreas(1)	6						tgctgccaccgctgctgctgctg	0.719													2	4	---	---	---	---					
FANCM	57697	broad.mit.edu	37	14	45642288	45642289	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:45642288_45642289delCT	ENST00000267430.5	+	13	2276_2277	c.2191_2192delCT	c.(2191-2193)cfs	p.L731fs	FANCM_ENST00000542564.2_Frame_Shift_Del_p.L705fs	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	731					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						AATTCATCAACTCTCTCTCTCT	0.347								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	247	---	---	---	---					
MGAT2	4247	broad.mit.edu	37	14	50088928	50088929	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr14:50088928_50088929delCA	ENST00000305386.2	+	1	1440_1441	c.942_943delCA	c.(940-945)tccafs	p.ST314fs	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	314					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					CTTGGAAATCCACAGAGCACAA	0.470													12	596	---	---	---	---					
ADAL	161823	broad.mit.edu	37	15	43641114	43641115	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr15:43641114_43641115insA	ENST00000422466.2	+	11	1217_1218	c.643_644insA	c.(643-645)aaafs	p.K215fs	ADAL_ENST00000562188.1_Frame_Shift_Ins_p.K215fs|ADAL_ENST00000389651.4_Frame_Shift_Ins_p.K215fs|ADAL_ENST00000428046.3_Frame_Shift_Ins_p.K188fs			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	215					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GATTCCAAACCAAAAAAAAGAA	0.455													19	44	---	---	---	---					
ALDH3A2	224	broad.mit.edu	37	17	19566719	19566724	+	In_Frame_Del	DEL	AATAGT	AATAGT	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:19566719_19566724delAATAGT	ENST00000176643.6	+	7	1460_1465	c.1014_1019delAATAGT	c.(1012-1020)ccg>cc	p.PIV338del	ALDH3A2_ENST00000579855.1_In_Frame_Del_p.PIV338del|ALDH3A2_ENST00000395575.2_In_Frame_Del_p.PIV338del|ALDH3A2_ENST00000571163.1_In_Frame_Del_p.PIV11del|ALDH3A2_ENST00000339618.4_In_Frame_Del_p.PIV338del|ALDH3A2_ENST00000581518.1_In_Frame_Del_p.PIV338del			P51648	AL3A2_HUMAN	aldehyde dehydrogenase 3 family, member A2	338					cellular aldehyde metabolic process|central nervous system development|epidermis development|lipid metabolic process|peripheral nervous system development	endoplasmic reticulum membrane|integral to membrane	3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(2)|prostate(1)	13	all_cancers(12;1.39e-05)|all_epithelial(12;0.00158)|Breast(13;0.245)				NADH(DB00157)	CAATTCTTCCAATAGTGCCTGTGAAA	0.345													25	18	---	---	---	---					
FTSJ3	117246	broad.mit.edu	37	17	61901501	61901503	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr17:61901501_61901503delTCC	ENST00000427159.2	-	12	1740_1742	c.1095_1097delGGA	c.(1093-1098)gaa>ga	p.EE365del		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	365					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GTTCAGTTGTtcctcctcctcct	0.562													7	287	---	---	---	---					
COL5A3	50509	broad.mit.edu	37	19	10078061	10078061	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr19:10078061delG	ENST00000264828.3	-	62	4505	c.4420delC	c.(4420-4422)gtfs	p.R1474fs		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1474	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			GTGTCTCCACGGGGGCCCATG	0.602													2	4	---	---	---	---					
PKDREJ	10343	broad.mit.edu	37	22	46653646	46653648	+	In_Frame_Del	DEL	ATA	ATA	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chr22:46653646_46653648delATA	ENST00000253255.5	-	1	5571_5573	c.5572_5574delTAT	c.(5572-5574)del	p.Y1858del		NM_006071.1	NP_006062.1	Q9NTG1	PKDRE_HUMAN	polycystin (PKD) family receptor for egg jelly	1858					acrosome reaction|neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity			NS(2)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(4)|kidney(5)|large_intestine(21)|lung(16)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	73		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00459)		CTTGAGGCTTATAAGTAAATCCA	0.404													121	24	---	---	---	---					
TXLNGY	246126	broad.mit.edu	37	Y	21758004	21758005	+	RNA	DEL	AG	AG	-			TCGA-86-7955-01A-11D-2184-08	TCGA-86-7955-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	bd0425ea-647a-4a13-a8ac-d1c009c8e071	707309c6-f162-4cf1-95e6-bf86061997d4	g.chrY:21758004_21758005delAG	ENST00000253320.4	+	0	3085_3086							Q9BZA5	CY15A_HUMAN												haematopoietic_and_lymphoid_tissue(1)	1						GAAAGACATCAGAGAGAGAGAG	0.347													3	5	---	---	---	---