Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF488	118738	broad.mit.edu	37	10	48370853	48370853	+	Missense_Mutation	SNP	G	G	C			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr10:48370853G>C	ENST00000395702.2	+	2	548	c.321G>C	c.(319-321)agG>agC	p.R107S	ZNF488_ENST00000586537.1_5'UTR|ZNF488_ENST00000494156.1_Missense_Mutation_p.G72A			Q96MN9	ZN488_HUMAN	zinc finger protein 488	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						AGCTGCCGAGGATGAAGGACC	0.662000													4	41					0	0	1	0	0
SLC38A3	10991	broad.mit.edu	37	3	50255129	50255129	+	RNA	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:50255129G>A	ENST00000420502.1	+	0	865							Q99624	S38A3_HUMAN	solute carrier family 38, member 3						cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)|cervix(1)|endometrium(1)|lung(3)	6				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	AAAGTTCCACGTGCCCTGCCC	0.577000													23	43					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54818795	54818795	+	Missense_Mutation	SNP	C	C	T	rs145816402	byFrequency	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr19:54818795C>T	ENST00000301219.3	-	7	922	c.803G>A	c.(802-804)cGc>cAc	p.R268H	LILRA5_ENST00000346508.3_Missense_Mutation_p.R256H	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	268					innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CATGCCCATGCGGATGAGATT	0.557000													6	117					0	0	1	0	0
DCBLD2	131566	broad.mit.edu	37	3	98530329	98530329	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:98530329G>A	ENST00000326840.6	-	11	1795	c.1433C>T	c.(1432-1434)cCt>cTt	p.P478L	DCBLD2_ENST00000326857.9_Missense_Mutation_p.P478L	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	478					cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						TATTTTTGGAGGGGCTGTAGT	0.353000													5	99					0	0	1	0	0
ZNF37A	7587	broad.mit.edu	37	10	38407308	38407308	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr10:38407308C>T	ENST00000351773.3	+	8	2059	c.1229C>T	c.(1228-1230)cCt>cTt	p.P410L	ZNF37A_ENST00000361085.4_Missense_Mutation_p.P410L	NM_001007094.2	NP_001007095.1	P17032	ZN37A_HUMAN	zinc finger protein 37A	410						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(13)|prostate(1)	28						GGTGAAAAACCTTATGAATGT	0.393000													5	64					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149493797	149493797	+	RNA	SNP	G	G	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr7:149493797G>T	ENST00000378016.2	+	0	6793							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGCTCGGATGAGGAGGGCTG	0.642000													6	27					3.59834e-05	3.59834e-05	1	1	0
DIP2A	23181	broad.mit.edu	37	21	47974581	47974581	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr21:47974581C>T	ENST00000318711.7	+	27	3434	c.3251C>T	c.(3250-3252)aCa>aTa	p.T1084I	DIP2A_ENST00000417564.2_Missense_Mutation_p.T1083I|DIP2A_ENST00000427143.2_Missense_Mutation_p.T1019I|DIP2A_ENST00000400274.1_Missense_Mutation_p.T1079I	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	1083					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		CTCGGCACCACACTGCCCACC	0.657000													9	9					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48807854	48807854	+	Missense_Mutation	SNP	C	C	T	rs144911860		TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr2:48807854C>T	ENST00000309835.3	+	1	92	c.82C>T	c.(82-84)Cct>Tct	p.P28S	STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.P28S|STON1_ENST00000406226.1_Missense_Mutation_p.P28S|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.P28S|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.P28S|STON1_ENST00000404752.1_Missense_Mutation_p.P28S|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.P28S|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.P28S					stonin 1									p.P28S(2)		NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AAAGAATTTTCCTCTGGAGAA	0.473000													9	104					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887393	155887393	+	Missense_Mutation	SNP	T	T	G			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:155887393T>G	ENST00000368320.3	-	11	1362	c.1337A>C	c.(1336-1338)cAg>cCg	p.Q446P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q446P			Q7Z7F0	K0907_HUMAN	KIAA0907	446	Pro-rich.									breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggctgggg	0.567000													15	57					0	0	1	0	0
GABBR2	9568	broad.mit.edu	37	9	101061590	101061590	+	Missense_Mutation	SNP	G	G	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr9:101061590G>T	ENST00000259455.2	-	17	2917	c.2458C>A	c.(2458-2460)Cca>Aca	p.P820T		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	820					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	GTCTTTTCTGGTGTGTCCTGC	0.517000													72	172					3.61678e-42	3.9837e-42	1	1	0
MYD88	4615	broad.mit.edu	37	3	38182083	38182083	+	Splice_Site	SNP	G	G	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:38182083G>T	ENST00000417037.2	+	3	891	c.707_splice	c.e3+1	p.G236_splice	MYD88_ENST00000443433.2_Intron|MYD88_ENST00000396334.3_Intron|MYD88_ENST00000424893.1_Intron|MYD88_ENST00000481122.1_Intron|MYD88_ENST00000495303.1_Intron	NM_001172567.1	NP_001166038.1	Q99836	MYD88_HUMAN	myeloid differentiation primary response 88	215	TIR.				3'-UTR-mediated mRNA stabilization|anti-apoptosis|cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-17 production|positive regulation of interleukin-23 production|positive regulation of interleukin-6 production|regulation of inflammatory response|response to interleukin-1|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|intrinsic to membrane|plasma membrane	death receptor binding|TIR domain binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(226)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	237				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		CCACGGGGTGGGTGCGTGGAT	0.592000			Mis		ABC-DLBCL								11	94					1.58986e-06	1.63283e-06	1	1	0
ATG9B	285973	broad.mit.edu	37	7	150718370	150718370	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr7:150718370C>T	ENST00000605938.1	-	5	943	c.868G>A	c.(868-870)Ggc>Agc	p.G290S	ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000605952.1_Missense_Mutation_p.G290S|ATG9B_ENST00000444312.1_Silent_p.P27P|ATG9B_ENST00000377974.2_Missense_Mutation_p.G290S	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	290					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCCAGAAGCCGGCAGCCAGG	0.637000													6	63					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166068	140166068	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr5:140166068C>T	ENST00000504120.2	+	1	193	c.193C>T	c.(193-195)Cgg>Tgg	p.R65W	PCDHA1_ENST00000378133.3_Missense_Mutation_p.R65W|PCDHA1_ENST00000394633.3_Missense_Mutation_p.R65W	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGCCTGTTCCGGGTGGCGTC	0.587000													55	179					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724643	138724643	+	Silent	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:138724643G>A	ENST00000383163.2	-	1	467	c.468C>T	c.(466-468)taC>taT	p.Y156Y		NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	156								p.Y156Y(1)		endometrium(3)|kidney(1)|lung(7)	11						CGTCCTCCTCGTAGGCCTCTT	0.632000													19	41					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43322938	43322938	+	Missense_Mutation	SNP	A	A	G			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr6:43322938A>G	ENST00000361428.2	-	4	2211	c.2134T>C	c.(2134-2136)Ttc>Ctc	p.F712L	ZNF318_ENST00000318149.3_Missense_Mutation_p.F712L	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	712					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GACTTTAGGAATGGAGGGCTG	0.517000													17	71					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36306786	36306786	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:36306786C>T	ENST00000373210.3	+	14	1990	c.1745C>T	c.(1744-1746)cCt>cTt	p.P582L		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		TTCCAGCAGCCTGTCATCTTC	0.507000													56	67					0	0	1	0	0
MCL1	4170	broad.mit.edu	37	1	150551665	150551665	+	Silent	SNP	C	C	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:150551665C>A	ENST00000369026.2	-	1	401	c.342G>T	c.(340-342)ccG>ccT	p.P114P	MCL1_ENST00000307940.3_Silent_p.P114P	NM_001197320.1|NM_021960.4	NP_001184249.1|NP_068779.1	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 (BCL2-related)	114	PEST-like.				anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CGTCAGCGGCCGGGGCTTCCA	0.721000													9	52					1.12685e-05	1.14188e-05	1	1	0
OR2L2	26246	broad.mit.edu	37	1	248201769	248201769	+	Missense_Mutation	SNP	T	T	A	rs143422408		TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:248201769T>A	ENST00000366479.2	+	1	296	c.200T>A	c.(199-201)cTc>cAc	p.L67H	OR2L13_ENST00000366478.2_Intron	NM_001004686.2	NP_001004686.1	Q8NH16	OR2L2_HUMAN	olfactory receptor, family 2, subfamily L, member 2	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(28)|ovary(1)|skin(4)|urinary_tract(1)	42	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CAGCTCTCCCTCATTGACCTA	0.388000													33	458					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10081545	10081545	+	Silent	SNP	G	G	C	rs17032283	by1000genomes	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:10081545G>C	ENST00000431693.1	+	8	749	c.711G>C	c.(709-711)ctG>ctC	p.L237L	FANCD2_ENST00000419585.1_Intron|FANCD2_ENST00000383806.1_Intron|FANCD2_ENST00000383807.1_Intron|FANCD2_ENST00000438741.1_Intron|FANCD2_ENST00000287647.3_Intron			Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	0	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TAAACCCTCTGTCATCATCTA	0.478000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				6	93					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95840728	95840728	+	Silent	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr13:95840728G>A	ENST00000376887.4	-	10	1446	c.1332C>T	c.(1330-1332)gtC>gtT	p.V444V	ABCC4_ENST00000536256.1_Silent_p.V369V|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000431522.1_Silent_p.V444V|ABCC4_ENST00000412704.1_Silent_p.V444V	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	444	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	CCACGGGGCCGACCACAGCTA	0.478000													35	110					0	0	1	0	0
RGL3	57139	broad.mit.edu	37	19	11510959	11510959	+	Missense_Mutation	SNP	C	C	T	rs117608091	byFrequency	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr19:11510959C>T	ENST00000380456.3	-	14	1562	c.1499G>A	c.(1498-1500)cGg>cAg	p.R500Q	RGL3_ENST00000393423.3_Missense_Mutation_p.R500Q	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	500	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						CTCAATGACCCGGGAGAGCCG	0.612000													7	84					0	0	1	0	0
KSR1	8844	broad.mit.edu	37	17	25936345	25936345	+	Nonsense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr17:25936345C>T	ENST00000398988.3	+	18	2315	c.1870C>T	c.(1870-1872)Cga>Tga	p.R624*	KSR1_ENST00000319524.6_Nonsense_Mutation_p.R761*|KSR1_ENST00000268763.6_Nonsense_Mutation_p.R624*|KSR1_ENST00000509603.2_Nonsense_Mutation_p.R739*	NM_014238.1	NP_055053.1	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras 1	759	Protein kinase.				Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(12)|prostate(2)|urinary_tract(1)	28	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		AGGCGTGGTCCGAGAGGGACG	0.542000													33	142					0	0	1	0	0
ADCY10	55811	broad.mit.edu	37	1	167829118	167829118	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:167829118C>T	ENST00000367848.1	-	16	2044	c.1547G>A	c.(1546-1548)cGg>cAg	p.R516Q	ADCY10_ENST00000367851.4_Missense_Mutation_p.R608Q|ADCY10_ENST00000545172.1_Missense_Mutation_p.R455Q			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	608					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						GGAAATCTCCCGAGAAATAGG	0.373000													30	163					0	0	1	0	0
CIDECP	152302	broad.mit.edu	37	3	10059658	10059658	+	RNA	SNP	G	G	T	rs9862221	by1000genomes	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:10059658G>T	ENST00000432401.1	-	0	505																											GGGGATGCCCGTCCTCTGTGG	0.597000													15	127					6.31663e-08	6.76146e-08	1	1	0
PLK1	5347	broad.mit.edu	37	16	23691507	23691507	+	Nonsense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr16:23691507C>T	ENST00000300093.4	+	2	622	c.511C>T	c.(511-513)Cga>Tga	p.R171*	PLK1_ENST00000564202.1_3'UTR	NM_005030.3	NP_005021.2	P53350	PLK1_HUMAN	polo-like kinase 1	171	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(48;0.0156)		GCACCGAAACCGAGTTATTCA	0.532000													10	211					0	0	1	0	0
MAML2	84441	broad.mit.edu	37	11	95712515	95712515	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr11:95712515G>A	ENST00000524717.1	-	5	4352	c.3068C>T	c.(3067-3069)gCa>gTa	p.A1023V		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	1023					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CATTTGCACTGCTGGTGTTAA	0.512000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								4	32					0	0	1	0	0
LRRK1	79705	broad.mit.edu	37	15	101605814	101605814	+	Silent	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr15:101605814C>T	ENST00000284395.5	+	33	5563	c.5163C>T	c.(5161-5163)tgC>tgT	p.C1721C	RP11-505E24.2_ENST00000559857.1_RNA|LRRK1_ENST00000388948.3_Silent_p.C1724C|LRRK1_ENST00000532145.1_3'UTR			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1724					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TGGAGATCTGCAGGCGGCTGG	0.627000													27	92					0	0	1	0	0
KIAA0408	9729	broad.mit.edu	37	6	127768034	127768034	+	Missense_Mutation	SNP	G	G	C			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr6:127768034G>C	ENST00000483725.3	-	5	1766	c.1430C>G	c.(1429-1431)aCc>aGc	p.T477S	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	477							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		AGTAGATGAGGTATCACAGGG	0.423000													25	74					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2815682	2815682	+	Missense_Mutation	SNP	C	C	G			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr16:2815682C>G	ENST00000301740.8	+	11	5702	c.5153C>G	c.(5152-5154)tCt>tGt	p.S1718C		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1718	Arg-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						GAAACTCGCTCTAGAACTCCC	0.597000													9	96					0	0	1	0	0
KLHL17	339451	broad.mit.edu	37	1	900406	900406	+	Silent	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:900406C>T	ENST00000338591.3	+	12	1871	c.1764C>T	c.(1762-1764)agC>agT	p.S588S		NM_198317.2	NP_938073.1	Q6TDP4	KLH17_HUMAN	kelch-like family member 17	588	Interaction with F-actin (By similarity).				actin cytoskeleton organization	actin cytoskeleton|cell junction|postsynaptic density|postsynaptic membrane	protein complex scaffold			central_nervous_system(1)|kidney(2)|lung(3)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.52e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.59e-23)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000469)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACGACGGTAGCTCCAGCCTCA	0.647000													20	94					0	0	1	0	0
RNASE3	6037	broad.mit.edu	37	14	21360107	21360107	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr14:21360107C>T	ENST00000304639.3	+	2	320	c.262C>T	c.(262-264)Cgc>Tgc	p.R88C		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	88					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	CCAAAGTATACGCTGCCCTCA	0.403000													7	177					0	0	1	0	0
EHHADH	1962	broad.mit.edu	37	3	184922343	184922343	+	Silent	SNP	T	T	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:184922343T>A	ENST00000231887.3	-	6	846	c.771A>T	c.(769-771)ctA>ctT	p.L257L	EHHADH_ENST00000456310.1_Silent_p.L161L	NM_001166415.1|NM_001966.3	NP_001159887.1|NP_001957.2	Q08426	ECHP_HUMAN	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	257	Enoyl-CoA hydratase / isomerase.					peroxisome	3-hydroxyacyl-CoA dehydrogenase activity|coenzyme binding|dodecenoyl-CoA delta-isomerase activity|enoyl-CoA hydratase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|prostate(2)|skin(3)	24	all_cancers(143;4.04e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.98e-32)|OV - Ovarian serous cystadenocarcinoma(80;5.55e-21)		NADH(DB00157)	GCAAAAGATATAGAAACAGCT	0.512000													67	186					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903362	4903362	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr11:4903362C>T	ENST00000380378.1	+	1	314	c.314C>T	c.(313-315)aCg>aTg	p.T105M	OR51T1_ENST00000322049.1_Missense_Mutation_p.T78M|MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGACCATTACGACCCTTCCC	0.443000													6	105					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5963299	5963299	+	Silent	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr12:5963299G>A	ENST00000546188.1	-	4	602	c.531C>T	c.(529-531)agC>agT	p.S177S	ANO2_ENST00000356134.5_Silent_p.S177S|ANO2_ENST00000327087.8_Silent_p.S177S			Q9NQ90	ANO2_HUMAN	anoctamin 2	181						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						TGGATCCCTGGCTTTTATTCT	0.458000													63	182					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46515726	46515726	+	Missense_Mutation	SNP	C	C	G			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr11:46515726C>G	ENST00000458649.2	-	10	2786	c.2368G>C	c.(2368-2370)Gct>Cct	p.A790P	AMBRA1_ENST00000298834.3_Missense_Mutation_p.A730P|AMBRA1_ENST00000529963.1_5'UTR|AMBRA1_ENST00000426438.1_Missense_Mutation_p.A761P|AMBRA1_ENST00000534300.1_Missense_Mutation_p.A730P|AMBRA1_ENST00000533727.1_Missense_Mutation_p.A671P|AMBRA1_ENST00000528950.1_Missense_Mutation_p.A761P|AMBRA1_ENST00000314845.3_Missense_Mutation_p.A700P			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	790					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		TTGCGTGGAGCTCGGTGCCTG	0.493000													4	25					0	0	1	0	0
ANKMY2	57037	broad.mit.edu	37	7	16649287	16649287	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr7:16649287G>A	ENST00000306999.2	-	7	1093	c.850C>T	c.(850-852)Cag>Tag	p.Q284*		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	284						cilium	zinc ion binding	p.Q284E(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		CGAACCAGCTGCTGGAGGAGT	0.398000													4	51					0	0	1	0	0
CCDC62	84660	broad.mit.edu	37	12	123286393	123286393	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr12:123286393C>T	ENST00000253079.6	+	9	2044	c.1700C>T	c.(1699-1701)cCg>cTg	p.P567L	CCDC62_ENST00000537566.1_Missense_Mutation_p.P328L|CCDC62_ENST00000392441.4_Missense_Mutation_p.P567L|CCDC62_ENST00000392440.2_Missense_Mutation_p.P328L	NM_201435.4	NP_958843.2	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62	567						cytoplasm|nucleus		p.P567Q(2)		breast(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(1)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		CATGACTCCCCGGCAAGGTGA	0.473000													22	332					0	0	1	0	0
EFR3A	23167	broad.mit.edu	37	8	132968110	132968110	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr8:132968110C>T	ENST00000254624.5	+	7	959	c.734C>T	c.(733-735)gCa>gTa	p.A245V	EFR3A_ENST00000519656.1_Missense_Mutation_p.A209V|EFR3A_ENST00000334503.4_Missense_Mutation_p.A245V	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	245						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CTGGGTCGAGCAACTTTTGGG	0.408000													6	91					0	0	1	0	0
POLE	5426	broad.mit.edu	37	12	133248870	133248870	+	Silent	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr12:133248870C>T	ENST00000320574.5	-	16	1768	c.1725G>A	c.(1723-1725)gaG>gaA	p.E575E	POLE_ENST00000535270.1_Silent_p.E548E	NM_006231.2	NP_006222.2	Q07864	DPOE1_HUMAN	polymerase (DNA directed), epsilon, catalytic subunit	575					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			NS(2)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(41)|ovary(3)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	89	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		GCAAGGTCTTCTCAACCCGCT	0.572000								DNA polymerases (catalytic subunits)					15	97					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55143067	55143067	+	Missense_Mutation	SNP	G	G	C			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr19:55143067G>C	ENST00000396331.1	+	5	544	c.187G>C	c.(187-189)Gaa>Caa	p.E63Q	LILRB1_ENST00000396315.1_Missense_Mutation_p.E63Q|LILRB1_ENST00000396317.1_Missense_Mutation_p.E63Q|LILRB1_ENST00000396327.3_Missense_Mutation_p.E63Q|LILRB1_ENST00000396321.2_Missense_Mutation_p.E63Q|LILRB1_ENST00000448689.1_Missense_Mutation_p.E63Q|LILRB1_ENST00000418536.2_Missense_Mutation_p.E63Q|LILRB1_ENST00000324602.7_Missense_Mutation_p.E63Q|LILRB1_ENST00000434867.2_Missense_Mutation_p.E63Q|LILRB1_ENST00000396332.4_Missense_Mutation_p.E63Q|LILRB1_ENST00000427581.2_Missense_Mutation_p.E99Q	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	63	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TCTATATAGAGAAAAGAAAAC	0.572000										HNSCC(37;0.09)			10	199					0	0	1	0	0
CHRNB4	1143	broad.mit.edu	37	15	78917350	78917350	+	Missense_Mutation	SNP	T	T	G			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr15:78917350T>G	ENST00000412074.2	-	5	754	c.643A>C	c.(643-645)Acc>Ccc	p.T215P	CHRNB4_ENST00000261751.3_3'UTR	NM_001256567.1	NP_001243496.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	0					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						CTGTGGCTGGTTTGATGGGGT	0.572000													11	23					0	0	1	0	0
RAET1K	646024	broad.mit.edu	37	6	150322031	150322031	+	RNA	SNP	C	C	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr6:150322031C>A	ENST00000533735.1	-	0	845					NR_024045.1																						AAAAAGTCTTCAAGCCATGTC	0.438000													6	55					1.06961e-07	1.12904e-07	1	1	0
NAPEPLD	222236	broad.mit.edu	37	7	102760466	102760466	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr7:102760466G>A	ENST00000417955.1	-	3	653	c.499C>T	c.(499-501)Cgt>Tgt	p.R167C	NAPEPLD_ENST00000465647.1_Missense_Mutation_p.R167C|NAPEPLD_ENST00000341533.4_Missense_Mutation_p.R167C|NAPEPLD_ENST00000455523.2_Missense_Mutation_p.R240C|NAPEPLD_ENST00000427257.1_Missense_Mutation_p.R167C			Q6IQ20	NAPEP_HUMAN	N-acyl phosphatidylethanolamine phospholipase D	167					phospholipid catabolic process	membrane	metal ion binding			endometrium(2)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						CACGGGGAACGACGAAATCGC	0.468000													51	206					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23895277	23895277	+	Silent	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr14:23895277G>A	ENST00000355349.3	-	19	2220	c.2058C>T	c.(2056-2058)aaC>aaT	p.N686N		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	686	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGACCAGGGGGTTGTCCATCA	0.567000													10	55					0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20222213	20222213	+	Silent	SNP	T	T	C			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chrX:20222213T>C	ENST00000379565.3	-	4	459	c.252A>G	c.(250-252)ttA>ttG	p.L84L	RPS6KA3_ENST00000544447.1_Silent_p.L56L|RPS6KA3_ENST00000379548.4_Silent_p.L55L|RPS6KA3_ENST00000540702.1_Silent_p.L56L	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	84	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						TTTTTTTAACTAAGAAAACCT	0.313000													8	87					0	0	1	0	0
CHIT1	1118	broad.mit.edu	37	1	203192374	203192374	+	Missense_Mutation	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr1:203192374G>A	ENST00000367229.1	-	6	528	c.494C>T	c.(493-495)gCc>gTc	p.A165V	CHIT1_ENST00000535569.1_Missense_Mutation_p.A156V|CHIT1_ENST00000484834.1_Intron|CHIT1_ENST00000255427.3_Missense_Mutation_p.A146V	NM_001270509.1|NM_003465.2	NP_001257438.1|NP_003456.1	Q13231	CHIT1_HUMAN	chitinase 1 (chitotriosidase)	165					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|stomach(2)	27						CTGCTGGAAGGCATTGGCCAA	0.597000													43	234					0	0	1	0	0
CIDECP	152302	broad.mit.edu	37	3	10065426	10065426	+	RNA	SNP	C	C	T	rs6803517	by1000genomes	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:10065426C>T	ENST00000432401.1	-	0	322																											GTGGGTGCCTCGTCCCCTGCA	0.502000													7	104					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38899691	38899691	+	Silent	SNP	G	G	A	rs112903128	byFrequency	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr6:38899691G>A	ENST00000359357.3	+	74	10982	c.10728G>A	c.(10726-10728)acG>acA	p.T3576T	DNAH8_ENST00000441566.1_Silent_p.T3540T|RP1-207H1.3_ENST00000453417.1_RNA|RP1-207H1.3_ENST00000416948.1_RNA|DNAH8_ENST00000449981.2_Silent_p.T3793T					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATGCTAAAACGTCAGTCATTG	0.358000													5	105					0	0	1	0	0
CIDECP	152302	broad.mit.edu	37	3	10059664	10059664	+	RNA	SNP	T	T	C	rs73017232	by1000genomes	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr3:10059664T>C	ENST00000432401.1	-	0	505																											GCCCGTCCTCTGTGGCATCGA	0.607000													10	123					0	0	1	0	0
TMEM259	91304	broad.mit.edu	37	19	1014372	1014372	+	Missense_Mutation	SNP	C	C	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr19:1014372C>T	ENST00000356663.3	-	2	447	c.326G>A	c.(325-327)gGc>gAc	p.G109D	TMEM259_ENST00000333175.5_Missense_Mutation_p.G109D	NM_001033026.1	NP_001028198.1			transmembrane protein 259																		ACGCAGGATGCCCTCACGCGG	0.657000													15	52					0	0	1	0	0
SOGA3	387104	broad.mit.edu	37	6	127836123	127836123	+	Nonsense_Mutation	SNP	G	G	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr6:127836123G>A	ENST00000556132.1	-	3	2035	c.1171C>T	c.(1171-1173)Caa>Taa	p.Q391*	SOGA3_ENST00000368268.2_Nonsense_Mutation_p.Q391*|SOGA3_ENST00000465909.2_Nonsense_Mutation_p.Q391*|SOGA3_ENST00000481848.2_Nonsense_Mutation_p.Q391*|SOGA3_ENST00000525778.1_Nonsense_Mutation_p.Q391*	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	391						integral to membrane											TCCTGCAGTTGACAGGCATCC	0.572000													69	229					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43992666	43992667	+	Frame_Shift_Ins	INS	-	-	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr2:43992666_43992667insA	ENST00000282406.4	+	30	4521_4522	c.4411_4412insA	c.(4411-4413)agcfs	p.S1471fs		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	1471						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CCGGGGACCCCAAGCCAGAATG	0.540													7	108	---	---	---	---					
ZNF876P	642280	broad.mit.edu	37	4	212236	212236	+	RNA	DEL	A	A	-	rs80061878		TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr4:212236delA	ENST00000356347.3	+	0	172					NR_027481.1																						ctaaaaatacaaaaaaaaaaa	0.493													3	3	---	---	---	---					
FBXL5	26234	broad.mit.edu	37	4	15627468	15627469	+	Frame_Shift_Ins	INS	-	-	A			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr4:15627468_15627469insA	ENST00000341285.3	-	9	1380_1381	c.1256_1257insT	c.(1255-1257)taafs	p.*419fs	FBXL5_ENST00000412094.2_Frame_Shift_Ins_p.*402fs|FBXL5_ENST00000382358.4_Frame_Shift_Ins_p.*293fs	NM_001193534.1|NM_001193535.1|NM_012161.3	NP_001180463.1|NP_001180464.1|NP_036293.1	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5	419					iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	13						TAGATGTTTTCAAAAAGCCACT	0.406													9	113	---	---	---	---					
PPP3CA	5530	broad.mit.edu	37	4	102014998	102014998	+	Frame_Shift_Del	DEL	A	A	-			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr4:102014998delA	ENST00000394854.3	-	6	1400	c.717delT	c.(715-717)ttfs	p.F239fs	PPP3CA_ENST00000323055.6_Frame_Shift_Del_p.F239fs|PPP3CA_ENST00000523694.2_Frame_Shift_Del_p.F172fs|PPP3CA_ENST00000394853.4_Frame_Shift_Del_p.F239fs|PPP3CA_ENST00000512215.1_Intron|PPP3CA_ENST00000507176.1_Frame_Shift_Del_p.F141fs	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	239	Catalytic.				protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		TCTCATTTCCAAAATCTTCCA	0.428													30	70	---	---	---	---					
DLC1	10395	broad.mit.edu	37	8	12957364	12957365	+	Frame_Shift_Ins	INS	-	-	G			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr8:12957364_12957365insG	ENST00000276297.4	-	9	2890_2891	c.2481_2482insC	c.(2479-2484)ttccccfs	p.FP827fs	DLC1_ENST00000512044.2_Frame_Shift_Ins_p.FP424fs|DLC1_ENST00000520226.1_Frame_Shift_Ins_p.FP316fs|DLC1_ENST00000358919.2_Frame_Shift_Ins_p.FP390fs	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	827					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCCGAGGGGGAGAAACTGCCAT	0.564													41	151	---	---	---	---					
DUSP8	1850	broad.mit.edu	37	11	1577819	1577820	+	Frame_Shift_Del	DEL	CG	CG	-	rs61747093		TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr11:1577819_1577820delCG	ENST00000397374.3	-	7	1933_1934	c.1806_1807delCG	c.(1804-1809)cggcfs	p.RG602fs	DUSP8_ENST00000331588.4_Frame_Shift_Del_p.RG602fs	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	602					inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		AGCTCCTCGCCGCGCGCGCGCC	0.752													2	4	---	---	---	---					
OR4N4	283694	broad.mit.edu	37	15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr15:22382920_22382921insT	ENST00000328795.4	+	1	539_540	c.448_449insT	c.(448-450)tggfs	p.W150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535													50	396	---	---	---	---					
NPIPB11	728888	broad.mit.edu	37	16	29394767	29394769	+	In_Frame_Del	DEL	TAT	TAT	-			TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr16:29394767_29394769delTAT	ENST00000524087.1	-	8	1558_1560	c.1484_1486delATA	c.(1483-1488)atc>a	p.NI495del	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11																		GGTGTCTTGATATTATCATCTGC	0.586													4	7	---	---	---	---					
MYLK3	91807	broad.mit.edu	37	16	46744687	46744688	+	Frame_Shift_Ins	INS	-	-	A	rs150139689	by1000genomes	TCGA-91-8496-01A-11D-2393-08	TCGA-91-8496-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	5ee73203-915b-497a-ade3-e807c719f673	60feb767-90be-4110-adbd-c922debce609	g.chr16:46744687_46744688insA	ENST00000394809.4	-	11	2243_2244	c.2128_2129insT	c.(2128-2130)cccfs	p.P710fs	MYLK3_ENST00000562104.1_5'UTR|MYLK3_ENST00000536476.1_Frame_Shift_Ins_p.P369fs	NM_182493.2	NP_872299.2	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	710	Protein kinase.				cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(5)|stomach(3)	37		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TAGAAATGGGGACAAGCCACTG	0.470													8	446	---	---	---	---