Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RHOXF1	158800	broad.mit.edu	37	X	119249500	119249500	+	Silent	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chrX:119249500C>A	ENST00000217999.2	-	1	347	c.273G>T	c.(271-273)gcG>gcT	p.A91A	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	91					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						CCTCCATGGCCGCCTGGGCCG	0.677000													55	71					1.54043e-34	1.723e-34	1	1	0
YLPM1	56252	broad.mit.edu	37	14	75302013	75302013	+	Missense_Mutation	SNP	A	A	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr14:75302013A>G	ENST00000325680.7	+	20	6464	c.6340A>G	c.(6340-6342)Agg>Ggg	p.R2114G	YLPM1_ENST00000552421.1_Missense_Mutation_p.R1408G	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	1919					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGATAGGAAAAGGGCCATAGG	0.428000													3	63					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168102133	168102133	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:168102133G>A	ENST00000409195.1	+	9	4320	c.4231G>A	c.(4231-4233)Gac>Aac	p.D1411N	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D1411N|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D1189N|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1236					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GCCCAGTATTGACCATATACA	0.338000													11	57					0	0	1	0	0
EPB41L4A	64097	broad.mit.edu	37	5	111576490	111576490	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:111576490G>C	ENST00000261486.5	-	10	1089	c.813C>G	c.(811-813)ttC>ttG	p.F271L	RP11-526F3.1_ENST00000504004.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	271	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		CTTCAAAAAAGAATGAGGTTT	0.363000													7	43					0	0	1	0	0
SPATA4	132851	broad.mit.edu	37	4	177116675	177116675	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr4:177116675C>T	ENST00000280191.2	-	1	147	c.39G>A	c.(37-39)caG>caA	p.Q13Q		NM_144644.2	NP_653245.2	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	13					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		CTGCCGCAGTCTGTGTCAAAT	0.612000													18	73					0	0	1	0	0
SFMBT1	51460	broad.mit.edu	37	3	52954585	52954585	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:52954585C>A	ENST00000394752.3	-	12	1722	c.1340G>T	c.(1339-1341)gGc>gTc	p.G447V	SFMBT1_ENST00000296295.6_Missense_Mutation_p.G447V|SFMBT1_ENST00000394750.1_Missense_Mutation_p.G447V|SFMBT1_ENST00000358080.2_Missense_Mutation_p.G447V	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	447					regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		GAGGGGGTGGCCGTTGGTTTC	0.433000													9	33					1.12685e-05	1.18163e-05	1	1	0
PLD1	5337	broad.mit.edu	37	3	171338216	171338216	+	Missense_Mutation	SNP	G	G	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:171338216G>T	ENST00000356327.5	-	23	2644	c.2574C>A	c.(2572-2574)caC>caA	p.H858Q	PLD1_ENST00000342215.6_3'UTR|PLD1_ENST00000351298.4_Missense_Mutation_p.H896Q|PLD1_ENST00000340989.4_Missense_Mutation_p.H896Q	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	896	Catalytic.				cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	ACAACTTGCTGTGGACATAGA	0.368000													12	76					3.27435e-08	3.45753e-08	1	1	0
ALDH3A1	218	broad.mit.edu	37	17	19648427	19648427	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:19648427C>T	ENST00000457500.2	-	1	345	c.16G>A	c.(16-18)Gag>Aag	p.E6K	ALDH3A1_ENST00000494157.2_Intron|ALDH3A1_ENST00000485231.1_Intron|ALDH3A1_ENST00000444455.1_Missense_Mutation_p.E6K|ALDH3A1_ENST00000395555.3_Missense_Mutation_p.E6K|ALDH3A1_ENST00000225740.6_Missense_Mutation_p.E6K	NM_001135168.1	NP_001128640.1	P30838	AL3A1_HUMAN	aldehyde dehydrogenase 3 family, member A1	6					cellular aldehyde metabolic process	cytosol|endoplasmic reticulum	alcohol dehydrogenase (NADP+) activity|aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|urinary_tract(1)	13	all_cancers(12;4.01e-05)|all_epithelial(12;0.00301)|Breast(13;0.186)			Colorectal(15;0.0829)	NADH(DB00157)	TTCACGGCCTCGCTGATCTTG	0.682000													16	29					0	0	1	0	0
MPHOSPH8	54737	broad.mit.edu	37	13	20220962	20220962	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr13:20220962G>C	ENST00000361479.5	+	3	817	c.749G>C	c.(748-750)aGa>aCa	p.R250T	MPHOSPH8_ENST00000414242.2_Missense_Mutation_p.R250T	NM_017520.3	NP_059990.2	Q99549	MPP8_HUMAN	M-phase phosphoprotein 8	250	Lys-rich.				cell cycle	cytoplasm|nucleus				breast(2)|endometrium(1)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_cancers(29;2.83e-16)|all_lung(29;1.16e-17)|all_epithelial(30;8.13e-16)|Lung NSC(5;6.91e-15)|Lung SC(185;0.0367)		all cancers(112;8.43e-05)|Epithelial(112;0.000426)|OV - Ovarian serous cystadenocarcinoma(117;0.00596)|Lung(94;0.015)|LUSC - Lung squamous cell carcinoma(192;0.0795)		aaagaaaatagaaaaacaaaa	0.313000													14	52					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164704982	164704982	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:164704982G>A	ENST00000264382.3	-	45	5203	c.5141C>T	c.(5140-5142)gCa>gTa	p.A1714V		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1714	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATTATCATCTGCAGCAACAAT	0.343000										HNSCC(35;0.089)			21	117					0	0	1	0	0
LTB4R	1241	broad.mit.edu	37	14	24785064	24785064	+	Silent	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr14:24785064C>G	ENST00000396789.4	+	2	1932	c.207C>G	c.(205-207)ctC>ctG	p.L69L	LTB4R_ENST00000396782.2_Silent_p.L69L|LTB4R_ENST00000345363.3_Silent_p.L69L	NM_181657.3	NP_858043.1	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	69					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|stomach(1)	8				GBM - Glioblastoma multiforme(265;0.018)		CCGTATTGCTCACTGCTCCCT	0.567000													26	100					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546491	11546491	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:11546491C>T	ENST00000389362.4	-	3	556	c.521G>A	c.(520-522)cGa>cAa	p.R174Q	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2									p.R153L(1)|p.R174L(1)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TGGAGGAGATCGAGAACTTCG	0.607000													6	565					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48874123	48874123	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr8:48874123G>A	ENST00000262105.2	+	2	327	c.118G>A	c.(118-120)Gag>Aag	p.E40K	MCM4_ENST00000523944.1_Missense_Mutation_p.E40K	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	40					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				ACGTAGAGGCGAGGATTCCAC	0.592000													31	50					0	0	1	0	0
STAT4	6775	broad.mit.edu	37	2	191898689	191898689	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:191898689C>A	ENST00000392320.2	-	19	1977	c.1663G>T	c.(1663-1665)Gaa>Taa	p.E555*	STAT4_ENST00000358470.4_Nonsense_Mutation_p.E555*	NM_003151.3	NP_003142.1	Q14765	STAT4_HUMAN	signal transducer and activator of transcription 4	555					JAK-STAT cascade	cytoplasm|nucleus	calcium ion binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(4)|endometrium(1)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(117;0.00854)|Epithelial(96;0.0864)|all cancers(119;0.204)			AATATTGCTTCAAGCCATGTC	0.294000													18	121					7.45023e-12	8.15206e-12	1	1	0
GALNT13	114805	broad.mit.edu	37	2	155099252	155099252	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:155099252G>T	ENST00000392825.3	+	6	1087	c.520G>T	c.(520-522)Gaa>Taa	p.E174*	GALNT13_ENST00000409237.1_Nonsense_Mutation_p.E174*	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	174	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						GAAAAATTTAGAAGTGCCAGT	0.343000													3	36					0.004672	0.00479913	1	1	0
EPG5	57724	broad.mit.edu	37	18	43450707	43450707	+	Splice_Site	SNP	T	T	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr18:43450707T>C	ENST00000282041.5	-	36	6084	c.6049_splice	c.e36-1	p.D2017_splice	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2017					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						CAACAGCTTATCTAGAATGTG	0.373000													8	41					0	0	1	0	0
BDP1	55814	broad.mit.edu	37	5	70812024	70812024	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:70812024G>A	ENST00000358731.4	+	21	5049	c.4786G>A	c.(4786-4788)Gaa>Aaa	p.E1596K	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	1596					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AGACAAAGGTGAAGCCAAAGG	0.378000													8	40					0	0	1	0	0
GOLGA2	2801	broad.mit.edu	37	9	131023764	131023764	+	Nonsense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr9:131023764C>T	ENST00000421699.2	-	15	1232	c.1220G>A	c.(1219-1221)tGg>tAg	p.W407*		NM_004486.4	NP_004477.3	Q08379	GOGA2_HUMAN	golgin A2	407						Golgi cisterna membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	34						CCTCTGCCGCCACATGGCGCT	0.498000													22	106					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579976	179579976	+	Missense_Mutation	SNP	C	C	T	rs144587343	by1000genomes	TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:179579976C>T	ENST00000589042.1	-	90	26161	c.25937G>A	c.(25936-25938)cGc>cAc	p.R8646H	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.R7402H|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R8329H|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8329	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGCTTTTTGCGGAAAATGGG	0.393000													33	63					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55453116	55453116	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr19:55453116G>A	ENST00000446217.1	-	4	450	c.48C>T	c.(46-48)ttC>ttT	p.F16F	NLRP7_ENST00000588756.1_5'UTR|NLRP7_ENST00000592784.1_5'UTR|NLRP7_ENST00000590030.1_5'UTR|NLRP7_ENST00000448121.2_5'UTR|NLRP7_ENST00000340844.2_5'UTR|NLRP7_ENST00000328092.5_5'UTR			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	0	DAPIN.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TAAGGCTGAAGAACTGGGGGG	0.473000													10	11					0	0	1	0	0
FCRL2	79368	broad.mit.edu	37	1	157738327	157738327	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:157738327G>A	ENST00000361516.3	-	5	808	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	FCRL2_ENST00000392274.3_Missense_Mutation_p.R254C|FCRL2_ENST00000368181.4_Intron	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	254	Ig-like C2-type 3.				cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GACAGGGAACGCTGGGTTTTC	0.517000													60	122					0	0	1	0	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31850286	31850286	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr22:31850286C>T	ENST00000397525.1	-	10	1579	c.1356G>A	c.(1354-1356)aaG>aaA	p.K452K	EIF4ENIF1_ENST00000330125.5_Silent_p.K452K|EIF4ENIF1_ENST00000344710.5_Silent_p.K289K|EIF4ENIF1_ENST00000382180.2_Silent_p.K131K|EIF4ENIF1_ENST00000397523.1_Silent_p.K452K|RP11-247I13.11_ENST00000464523.1_RNA	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	452						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GAGTTGAATTCTTCACTTGCT	0.488000													35	54					0	0	1	0	0
TNNI3K	51086	broad.mit.edu	37	1	74902157	74902157	+	Splice_Site	SNP	G	G	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:74902157G>T	ENST00000370891.2	+	21	2144		c.e21-1		FPGT-TNNI3K_ENST00000370899.3_Splice_Site|TNNI3K_ENST00000326637.3_Splice_Site|FPGT-TNNI3K_ENST00000557284.1_Splice_Site	NM_001112808.2	NP_001106279.1			TNNI3 interacting kinase											cervix(1)|endometrium(3)|kidney(5)|large_intestine(21)|lung(31)|ovary(4)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	76						CTTTCCCTCAGAATCAAGATT	0.328000													3	23					1	1	1	1	0
IPP	3652	broad.mit.edu	37	1	46211802	46211802	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:46211802G>A	ENST00000396478.3	-	2	384	c.282C>T	c.(280-282)ttC>ttT	p.F94F		NM_005897.2	NP_005888.1	Q9Y573	IPP_HUMAN	intracisternal A particle-promoted polypeptide	94	BTB.					actin cytoskeleton|cytoplasm	actin binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|stomach(2)	20	Acute lymphoblastic leukemia(166;0.155)					CTGTGTAAATGAAATCTAGAA	0.353000													14	47					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21015720	21015720	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:21015720C>T	ENST00000381545.3	+	8	878	c.659C>T	c.(658-660)cCa>cTa	p.P220L	SLCO1B3_ENST00000553473.1_Missense_Mutation_p.P220L|LST3_ENST00000540229.1_Missense_Mutation_p.P220L|SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000261196.2_Missense_Mutation_p.P220L	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	220					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					ATGATTGGTCCAGTCATTGGC	0.333000													8	237					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941649	144941649	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr8:144941649C>A	ENST00000525985.1	-	2	5844	c.5773G>T	c.(5773-5775)Gca>Tca	p.A1925S				P58107	EPIPL_HUMAN	epiplakin 1	1925						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCGCAAATGCTGCAGGGATG	0.652000													33	84					2.08457e-15	2.29759e-15	1	1	0
EVPL	2125	broad.mit.edu	37	17	74006263	74006263	+	Missense_Mutation	SNP	T	T	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:74006263T>A	ENST00000301607.3	-	22	3276	c.3023A>T	c.(3022-3024)aAg>aTg	p.K1008M	EVPL_ENST00000586740.1_Missense_Mutation_p.K1030M	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1008	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CTGCATGGTCTTCCTCTTGCT	0.657000													13	92					0	0	1	0	0
PTGS1	5742	broad.mit.edu	37	9	125148839	125148839	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr9:125148839G>A	ENST00000362012.2	+	9	1129	c.1124G>A	c.(1123-1125)cGc>cAc	p.R375H	AL162424.1_ENST00000600713.1_Intron|PTGS1_ENST00000540753.1_Missense_Mutation_p.R350H|PTGS1_ENST00000373698.5_Missense_Mutation_p.R266H|PTGS1_ENST00000223423.4_Missense_Mutation_p.R375H	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	375					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TACCGCAACCGCATTGCCATG	0.537000													4	237					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141242971	141242971	+	Silent	SNP	A	A	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:141242971A>G	ENST00000389484.3	-	59	10337	c.9366T>C	c.(9364-9366)acT>acC	p.T3122T		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3122					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TAACGAGTATAGTAGGGTACA	0.378000										TSP Lung(27;0.18)			7	38					0	0	1	0	0
GSE1	23199	broad.mit.edu	37	16	85667701	85667701	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr16:85667701G>A	ENST00000253458.7	+	2	365	c.189G>A	c.(187-189)gcG>gcA	p.A63A	GSE1_ENST00000393243.1_Intron|GSE1_ENST00000405402.2_Intron	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		TTGCCGCCGCGCTGCGCAAGC	0.766000													6	21					0	0	1	0	0
CNTNAP1	8506	broad.mit.edu	37	17	40842164	40842164	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:40842164C>T	ENST00000264638.4	+	12	2011	c.1794C>T	c.(1792-1794)ttC>ttT	p.F598F	CTD-3193K9.3_ENST00000592440.1_RNA	NM_003632.2	NP_003623.1	P78357	CNTP1_HUMAN	contactin associated protein 1	598	Fibrinogen C-terminal.				axon guidance|cell adhesion	paranode region of axon	receptor activity|receptor binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|lung(15)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.143)		CTGGAAACTTCACCATTGATC	0.488000													37	309					0	0	1	0	0
FUBP1	8880	broad.mit.edu	37	1	78435673	78435673	+	Silent	SNP	T	T	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:78435673T>A	ENST00000370767.1	-	2	234	c.147A>T	c.(145-147)gcA>gcT	p.A49A	FUBP1_ENST00000436586.2_Silent_p.A49A|FUBP1_ENST00000370768.2_Silent_p.A49A			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	49					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						GTGATGTCCCTGCATCACCTC	0.299000			"""F, N"""		oligodendroglioma								9	33					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92534952	92534952	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:92534952G>A	ENST00000298047.6	+	9	8790	c.8773G>A	c.(8773-8775)Gcg>Acg	p.A2925T	FAT3_ENST00000409404.2_Missense_Mutation_p.A2925T|FAT3_ENST00000525166.1_Missense_Mutation_p.A2775T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2925	Cadherin 27.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding	p.A2925T(2)		NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACCAGTCTTCGCGCAGGAAGT	0.562000										TCGA Ovarian(4;0.039)			19	85					0	0	1	0	0
BTBD11	121551	broad.mit.edu	37	12	108003971	108003971	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:108003971G>A	ENST00000280758.5	+	5	2176	c.1648G>A	c.(1648-1650)Gac>Aac	p.D550N	BTBD11_ENST00000490090.2_Missense_Mutation_p.D550N|BTBD11_ENST00000420571.2_Missense_Mutation_p.D550N|BTBD11_ENST00000357167.4_Missense_Mutation_p.D87N|RP11-128P10.1_ENST00000548473.1_RNA	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	550						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CCTTAGGGCCGACGACTGCTT	0.562000											OREG0022090	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	127					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54107803	54107803	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chrX:54107803C>T	ENST00000375180.2	-	14	2986	c.2930G>A	c.(2929-2931)cGa>cAa	p.R977Q	FAM120C_ENST00000328235.4_Missense_Mutation_p.E840K	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	977										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GAAGGATCCTCGGCCCCTGGA	0.557000													22	36					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170883549	170883549	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:170883549G>A	ENST00000274625.5	+	5	908	c.364G>A	c.(364-366)Ggc>Agc	p.G122S		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	122					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCAGCCCGATGGCACCAGCAA	0.522000													48	101					0	0	1	0	0
CLEC5A	23601	broad.mit.edu	37	7	141635717	141635717	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:141635717C>T	ENST00000546910.1	-	5	438	c.242G>A	c.(241-243)aGa>aAa	p.R81K	CLEC5A_ENST00000438351.1_Missense_Mutation_p.R58K|CLEC5A_ENST00000470595.1_Intron|CLEC5A_ENST00000551012.2_Missense_Mutation_p.R58K|CLEC5A_ENST00000439991.1_Intron	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	81	C-type lectin.				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					GAAAAAACATCTTGCTTGATA	0.413000													11	133					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74007749	74007749	+	Splice_Site	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:74007749C>A	ENST00000301607.3	-	21	2822	c.2568_splice	c.e21-1	p.E857_splice	EVPL_ENST00000586740.1_Splice_Site_p.E879_splice	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	857	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						AGGTTCTTCTCCTGGAGAAGG	0.567000													8	57					0.27861	0.280468	1	1	0
FANCL	55120	broad.mit.edu	37	2	58449124	58449124	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:58449124C>A	ENST00000402135.3	-	5	363	c.327G>T	c.(325-327)caG>caT	p.Q109H	FANCL_ENST00000233741.4_Missense_Mutation_p.Q109H|FANCL_ENST00000403676.1_Intron|FANCL_ENST00000403295.3_Missense_Mutation_p.Q109H|FANCL_ENST00000481670.1_5'UTR|FANCL_ENST00000540646.1_Missense_Mutation_p.Q109H	NM_001114636.1	NP_001108108.1	Q9NW38	FANCL_HUMAN	Fanconi anemia, complementation group L	109					DNA repair	cytoplasm|nucleoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)	8						TTGAGTAGAACTGGGGAGGAG	0.353000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				12	45					1.5842e-08	1.68461e-08	1	1	0
CEACAM4	1089	broad.mit.edu	37	19	42133303	42133303	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr19:42133303C>T	ENST00000221954.2	-	1	139	c.29G>A	c.(28-30)gGa>gAa	p.G10E	CEACAM4_ENST00000600925.1_Missense_Mutation_p.G10E	NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4	10						integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						CCTGTGCCCTCCACGGGGAGC	0.652000													12	27					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154185268	154185268	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chrX:154185268G>A	ENST00000360256.4	-	11	1916	c.1716C>T	c.(1714-1716)atC>atT	p.I572I		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	572	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	CTTTGTAGCAGATGAGGAGAG	0.458000													33	172					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140802867	140802867	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:140802867G>A	ENST00000398587.2	+	1	2106	c.2073G>A	c.(2071-2073)tcG>tcA	p.S691S	PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGACCTCTCGCTGTACTTGG	0.627000													19	155					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79409908	79409908	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:79409908G>A	ENST00000307745.7	+	9	1533	c.1533G>A	c.(1531-1533)ccG>ccA	p.P511P																								ACCAGGACCCGCTGGGCGGGA	0.652000													4	71					0	0	1	0	0
TCP11L2	255394	broad.mit.edu	37	12	106704939	106704939	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:106704939C>T	ENST00000546625.1	+	2	245	c.86C>T	c.(85-87)tCg>tTg	p.S29L	TCP11L2_ENST00000299045.3_Missense_Mutation_p.S29L|TCP11L2_ENST00000547153.1_Missense_Mutation_p.S29L			Q8N4U5	T11L2_HUMAN	t-complex 11, testis-specific-like 2	29	Ser-rich.									endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						AGCATGGCTTCGCTCAGTGAC	0.542000													15	83					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149493701	149493701	+	RNA	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:149493701C>T	ENST00000378016.2	+	0	6697							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ACCGGCACCTCTGTGCCCAGG	0.657000													9	69					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50954884	50954884	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr10:50954884C>A	ENST00000374103.4	-	10	1293	c.1208G>T	c.(1207-1209)gGc>gTc	p.G403V	OGDHL_ENST00000432695.1_Missense_Mutation_p.G194V|OGDHL_ENST00000419399.1_Missense_Mutation_p.G346V	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	403					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CACGCCCTGGCCAGCAAAGGC	0.632000													25	55					5.35356e-11	5.81574e-11	1	1	0
SVIL	6840	broad.mit.edu	37	10	29777528	29777528	+	Splice_Site	SNP	A	A	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr10:29777528A>T	ENST00000375398.2	-	25	4798		c.e25+1		SVIL_ENST00000355867.4_Splice_Site|SVIL_ENST00000375400.3_Splice_Site|SVIL_ENST00000535393.1_Splice_Site|SVIL_ENST00000538146.1_Splice_Site			O95425	SVIL_HUMAN	supervillin						cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				GCTCTGAAATACCTTTAATCT	0.547000													5	4					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10355577	10355577	+	Missense_Mutation	SNP	C	C	T	rs149818821		TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:10355577C>T	ENST00000255381.2	-	27	3529	c.3419G>A	c.(3418-3420)cGc>cAc	p.R1140H	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1140					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GAGGTCAGAGCGCTGCTTCTC	0.582000													56	58					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578534	7578534	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:7578534C>A	ENST00000420246.2	-	5	528	c.396G>T	c.(394-396)aaG>aaT	p.K132N	TP53_ENST00000269305.4_Missense_Mutation_p.K132N|TP53_ENST00000413465.2_Missense_Mutation_p.K132N|TP53_ENST00000359597.4_Missense_Mutation_p.K132N|TP53_ENST00000445888.2_Missense_Mutation_p.K132N|TP53_ENST00000455263.2_Missense_Mutation_p.K132N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	132	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		K -> E (in LFS; germline mutation and in sporadic cancers; somatic mutation).|K -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|K -> M (in sporadic cancers; somatic mutation).|K -> N (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).|K -> W (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|KM -> NL (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K132N(49)|p.0?(8)|p.Y126_K132delYSPALNK(6)|p.K39N(2)|p.N131fs*27(2)|p.V73fs*9(1)|p.S127fs*36(1)|p.A129_K132delALNK(1)|p.Y126fs*11(1)|p.K132K(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.L130_M133delLNKM(1)|p.M133fs*37(1)|p.M133fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCAAAACATCTTGTTGAGGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	17					1.40151e-16	1.55609e-16	1	1	0
THSD7A	221981	broad.mit.edu	37	7	11514014	11514014	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:11514014C>G	ENST00000423059.3	-	8	2450	c.2199G>C	c.(2197-2199)caG>caC	p.Q733H	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	733	TSP type-1 7.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTTTTCTTGTCTGCATGCCGA	0.507000										HNSCC(18;0.044)			7	86					0	0	1	0	0
GDNF	2668	broad.mit.edu	37	5	37816164	37816164	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:37816164C>T	ENST00000326524.2	-	3	424	c.225G>A	c.(223-225)ctG>ctA	p.L75L	GDNF_ENST00000381826.4_Silent_p.L66L|GDNF_ENST00000427982.1_Silent_p.L92L|GDNF_ENST00000515058.1_Silent_p.L49L|GDNF_ENST00000344622.4_Silent_p.L49L	NM_000514.3	NP_000505.1	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor	75					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity			NS(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(8)|skin(2)	15	all_lung(31;0.00118)					GTGACCTTTTCAGTCTTTTAA	0.438000													12	106					0	0	1	0	0
GPX8	493869	broad.mit.edu	37	5	54460038	54460038	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:54460038G>A	ENST00000503787.1	+	3	697	c.622G>A	c.(622-624)Gat>Aat	p.D208N	GPX8_ENST00000515370.1_Missense_Mutation_p.D157N|CDC20B_ENST00000296733.1_Intron|CDC20B_ENST00000381375.2_Intron|GPX8_ENST00000296734.6_3'UTR|CDC20B_ENST00000331730.3_Intron|CDC20B_ENST00000322374.6_Intron|GPX8_ENST00000506123.1_3'UTR|CDC20B_ENST00000334206.5_Intron	NM_001008397.2	NP_001008398.2	Q8TED1	GPX8_HUMAN	glutathione peroxidase 8 (putative)	208					response to oxidative stress	integral to membrane	glutathione peroxidase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)	11					Glutathione(DB00143)	AAAGAAAGAGGATCTATGAGA	0.413000													10	45					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74006262	74006262	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:74006262C>T	ENST00000301607.3	-	22	3277	c.3024G>A	c.(3022-3024)aaG>aaA	p.K1008K	EVPL_ENST00000586740.1_Silent_p.K1030K	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1008	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCTGCATGGTCTTCCTCTTGC	0.657000													14	93					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113860378	113860378	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:113860378C>T	ENST00000504030.2	+	9	1775	c.1330C>T	c.(1330-1332)Cgc>Tgc	p.R444C	HTR3A_ENST00000506841.2_Missense_Mutation_p.R476C|HTR3A_ENST00000375498.2_Missense_Mutation_p.R450C|HTR3A_ENST00000299961.5_Missense_Mutation_p.R429C|HTR3A_ENST00000355556.2_Missense_Mutation_p.R482C|HTR3A_ENST00000535865.1_Missense_Mutation_p.R188C			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	444	HA-stretch.				digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity	p.R476C(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	AGACTGGCTGCGCGTGGGCTC	0.612000													24	87					0	0	1	0	0
GPR137	56834	broad.mit.edu	37	11	64055813	64055813	+	Splice_Site	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:64055813C>T	ENST00000539851.1	+	6	1252	c.783_splice	c.e6-1	p.A262_splice	GPR137_ENST00000438980.2_Splice_Site_p.A262_splice|GPR137_ENST00000411458.1_Splice_Site_p.A320_splice|GPR137_ENST00000377702.4_Splice_Site_p.A212_splice|GPR137_ENST00000313074.3_Splice_Site_p.A262_splice	NM_001177358.1	NP_001170829.1	Q96N19	G137A_HUMAN	G protein-coupled receptor 137	262						integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|lung(4)|skin(1)	10						TTCCCACAGGCGGACCTGGTG	0.627000													47	189					0	0	1	0	0
CAGE1	285782	broad.mit.edu	37	6	7378910	7378910	+	Silent	SNP	A	A	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr6:7378910A>C	ENST00000502583.1	-	4	1191	c.627T>G	c.(625-627)gcT>gcG	p.A209A	CAGE1_ENST00000509324.1_Intron|CAGE1_ENST00000379918.4_Silent_p.A209A|CAGE1_ENST00000512086.1_Silent_p.A209A|CAGE1_ENST00000338150.4_Silent_p.A209A|CAGE1_ENST00000296742.7_Silent_p.A73A	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	209										breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					CAATACTTTTAGCCAGTGACT	0.418000													74	100					0	0	1	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19436477	19436477	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:19436477G>A	ENST00000538714.1	+	11	1563	c.1559G>A	c.(1558-1560)cGa>cAa	p.R520Q	PLEKHA5_ENST00000299275.6_Missense_Mutation_p.R520Q|PLEKHA5_ENST00000539256.1_Missense_Mutation_p.R278Q|PLEKHA5_ENST00000424268.1_Missense_Mutation_p.R412Q|PLEKHA5_ENST00000309364.4_Missense_Mutation_p.R520Q|PLEKHA5_ENST00000359180.3_Missense_Mutation_p.R520Q|PLEKHA5_ENST00000543806.1_Missense_Mutation_p.R412Q|PLEKHA5_ENST00000429027.2_Missense_Mutation_p.R526Q|PLEKHA5_ENST00000355397.3_Missense_Mutation_p.R520Q|PLEKHA5_ENST00000317589.4_Missense_Mutation_p.R520Q|PLEKHA5_ENST00000510738.2_3'UTR	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	520							1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					ACCCTCCCTCGACACAGTACT	0.483000													32	223					0	0	1	0	0
TRBV11-1	28582	broad.mit.edu	37	7	142223887	142223887	+	RNA	SNP	A	A	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:142223887A>T	ENST00000390367.3	-	0	296																											TTGAGAGTGGAGTCTACTCCT	0.522000													24	398					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29786135	29786135	+	Missense_Mutation	SNP	A	A	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:29786135A>T	ENST00000256062.5	-	6	1222	c.749T>A	c.(748-750)aTc>aAc	p.I250N	TMTC1_ENST00000552618.1_Missense_Mutation_p.I420N|TMTC1_ENST00000551659.1_Missense_Mutation_p.I420N|TMTC1_ENST00000539277.1_Missense_Mutation_p.I358N|TMTC1_ENST00000381224.2_Missense_Mutation_p.I312N|TMTC1_ENST00000319685.8_5'UTR	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	358						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					CGCCAGAAAGATGGTGGCTAA	0.488000													33	73					0	0	1	0	0
MYEF2	50804	broad.mit.edu	37	15	48450996	48450996	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr15:48450996C>T	ENST00000324324.7	-	7	1120	c.841G>A	c.(841-843)Gag>Aag	p.E281K	MYEF2_ENST00000557868.1_5'UTR|MYEF2_ENST00000267836.6_Missense_Mutation_p.E281K	NM_016132.3	NP_057216.2	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	281	RRM 2.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		ATTGCTTGCTCAAAAGTGACA	0.418000													10	129					0	0	1	0	0
RALB	5899	broad.mit.edu	37	2	121036307	121036307	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:121036307G>A	ENST00000272519.5	+	2	337	c.67G>A	c.(67-69)Gga>Aga	p.G23R	RALB_ENST00000474855.2_Missense_Mutation_p.G45R|RALB_ENST00000470417.1_Intron|RALB_ENST00000404963.3_Missense_Mutation_p.G23R|RALB_ENST00000420510.1_Missense_Mutation_p.G23R	NM_002881.2	NP_002872.1	P11234	RALB_HUMAN	v-ral simian leukemia viral oncogene homolog B	23					apoptosis|cell cycle|cytokinesis|nerve growth factor receptor signaling pathway|Ras protein signal transduction|regulation of exocyst assembly|regulation of exocyst localization	cytosol|midbody|plasma membrane	GTP binding|GTPase activity|protein binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		Prostate(154;0.122)				GGTTGGCAGCGGAGGCGTTGG	0.567000													7	36					0	0	1	0	0
SLC19A3	80704	broad.mit.edu	37	2	228560705	228560705	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:228560705C>T	ENST00000258403.3	-	4	1143	c.1072G>A	c.(1072-1074)Ggt>Agt	p.G358S	SLC19A3_ENST00000409287.1_Intron|SLC19A3_ENST00000541617.1_Missense_Mutation_p.G354S	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	358					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	AATAAAGAACCGGCATTGACA	0.463000													19	117					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187447543	187447543	+	Missense_Mutation	SNP	C	C	T	rs142220629		TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:187447543C>T	ENST00000406870.2	-	5	1016	c.650G>A	c.(649-651)cGg>cAg	p.R217Q	RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000450123.2_Missense_Mutation_p.R217Q|RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000232014.4_Missense_Mutation_p.R217Q	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	217					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R217Q(1)		central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		CACAGGCATCCGGACATCCCG	0.612000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								11	47					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136596780	136596780	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr6:136596780T>G	ENST00000531224.1	-	6	1994	c.1742A>C	c.(1741-1743)aAg>aCg	p.K581T	BCLAF1_ENST00000527759.1_Missense_Mutation_p.K579T|BCLAF1_ENST00000353331.4_Missense_Mutation_p.K579T|BCLAF1_ENST00000530767.1_Missense_Mutation_p.K408T|BCLAF1_ENST00000527536.1_Missense_Mutation_p.K581T|BCLAF1_ENST00000392348.2_Missense_Mutation_p.K579T	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	581					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTCTTGCTCCTTCTTGACAGA	0.418000													7	170					0	0	1	0	0
GCC2	9648	broad.mit.edu	37	2	109099619	109099619	+	Missense_Mutation	SNP	A	A	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:109099619A>C	ENST00000309863.6	+	12	4161	c.3447A>C	c.(3445-3447)aaA>aaC	p.K1149N		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	1149					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						AGCTGGTTAAAAAGGTAAAAT	0.343000													9	22					0	0	1	0	0
ARID1A	8289	broad.mit.edu	37	1	27056237	27056237	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:27056237G>A	ENST00000324856.7	+	2	1604	c.1233G>A	c.(1231-1233)ccG>ccA	p.P411P	ARID1A_ENST00000457599.2_Silent_p.P411P|ARID1A_ENST00000374152.2_Silent_p.P28P	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	411					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CGTCAGGACCGCAGCAAGGAC	0.632000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								4	121					0	0	1	0	0
ICA1L	130026	broad.mit.edu	37	2	203644330	203644330	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:203644330G>A	ENST00000392237.2	-	14	1532	c.1375C>T	c.(1375-1377)Ctg>Ttg	p.L459L	ICA1L_ENST00000358299.2_Silent_p.L459L	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	459										breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCTGCAAACAGATTGAACCAG	0.363000													13	40					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84566694	84566694	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr15:84566694C>G	ENST00000286744.5	+	14	1776	c.1552C>G	c.(1552-1554)Cca>Gca	p.P518A	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.P518A	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	518	TSP type-1 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GGGCTGCAATCCACAACTGAA	0.453000													12	52					0	0	1	0	0
TRIP12	9320	broad.mit.edu	37	2	230662490	230662490	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:230662490G>A	ENST00000283943.5	-	23	3493	c.3315C>T	c.(3313-3315)ttC>ttT	p.F1105F	TRIP12_ENST00000389044.4_Silent_p.F1153F|TRIP12_ENST00000389045.3_Silent_p.F835F|TRIP12_ENST00000543084.1_3'UTR	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	1105					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TCTCAGAACTGAAATAACGTT	0.403000													10	90					0	0	1	0	0
AHI1	54806	broad.mit.edu	37	6	135776901	135776901	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr6:135776901C>T	ENST00000367800.4	-	8	1531	c.1315G>A	c.(1315-1317)Gag>Aag	p.E439K	AHI1_ENST00000327035.6_Missense_Mutation_p.E439K|AHI1_ENST00000457866.2_Missense_Mutation_p.E439K	NM_001134830.1	NP_001128302.1	Q8N157	AHI1_HUMAN	Abelson helper integration site 1	439						adherens junction|cilium|microtubule basal body				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)	37	Breast(56;0.239)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00904)|OV - Ovarian serous cystadenocarcinoma(155;0.00991)		TTAGGACTCTCATCAGAGCCT	0.318000													4	8					0	0	1	0	0
PPP4R2	151987	broad.mit.edu	37	3	73047268	73047268	+	Silent	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:73047268G>C	ENST00000356692.5	+	2	328	c.75G>C	c.(73-75)ctG>ctC	p.L25L	PPP4R2_ENST00000295862.9_5'UTR|PPP4R2_ENST00000495566.1_Silent_p.L25L|PPP4R2_ENST00000394284.3_Silent_p.L25L			Q9NY27	PP4R2_HUMAN	protein phosphatase 4, regulatory subunit 2	25					mRNA processing|protein modification process|regulation of double-strand break repair via homologous recombination|RNA splicing	centrosome|nucleus|protein phosphatase 4 complex	protein binding, bridging|protein phosphatase type 4 regulator activity			breast(2)|endometrium(1)|large_intestine(1)|lung(3)|skin(2)|stomach(1)|urinary_tract(2)	12		Prostate(10;0.0187)|Lung SC(41;0.236)		Epithelial(33;1.76e-07)|BRCA - Breast invasive adenocarcinoma(55;9.42e-05)|LUSC - Lung squamous cell carcinoma(21;0.00211)|Lung(16;0.00643)|KIRC - Kidney renal clear cell carcinoma(39;0.0164)|Kidney(39;0.0193)|OV - Ovarian serous cystadenocarcinoma(275;0.031)		GTCCTGTCCTGGATCAGTTTC	0.373000													23	149					0	0	1	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166219	19166219	+	Silent	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:19166219G>C	ENST00000375371.3	-	6	2415	c.2394C>G	c.(2392-2394)ctC>ctG	p.L798L		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	798					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CCAGGAGGTTGAGCACAGTGA	0.577000													8	43					0	0	1	0	0
AHCYL2	23382	broad.mit.edu	37	7	129053479	129053479	+	Missense_Mutation	SNP	A	A	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:129053479A>T	ENST00000325006.3	+	12	1465	c.1411A>T	c.(1411-1413)Aat>Tat	p.N471Y	AHCYL2_ENST00000446544.2_Missense_Mutation_p.N470Y|AHCYL2_ENST00000531335.2_Missense_Mutation_p.N390Y|AHCYL2_ENST00000474594.1_Missense_Mutation_p.N368Y|AHCYL2_ENST00000490911.1_Missense_Mutation_p.N368Y|AHCYL2_ENST00000446212.1_Missense_Mutation_p.N369Y	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	471					one-carbon metabolic process		adenosylhomocysteinase activity	p.N471Y(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						CCGTATGAAGAATAGCTGCAT	0.423000													59	212					0	0	1	0	0
SLC13A2	9058	broad.mit.edu	37	17	26821425	26821425	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:26821425G>A	ENST00000444914.3	+	9	1770	c.1350G>A	c.(1348-1350)ctG>ctA	p.L450L	SLC13A2_ENST00000537681.1_Silent_p.L330L|SLC13A2_ENST00000314669.5_Silent_p.L401L|SLC13A2_ENST00000545060.1_Silent_p.L358L	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	401						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CAGGGAAGCTGAAGGCCCCTC	0.567000											OREG0024276	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	25	72					0	0	1	0	0
NOTUM	147111	broad.mit.edu	37	17	79914823	79914823	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:79914823G>A	ENST00000409678.3	-	7	1206	c.823C>T	c.(823-825)Cgc>Tgc	p.R275C		NM_178493.5	NP_848588.3	Q6P988	NOTUM_HUMAN	notum pectinacetylesterase homolog (Drosophila)	275						extracellular region	hydrolase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	15	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TCTGTGTGGCGATACTGCTTG	0.672000													15	62					0	0	1	0	0
ZNF764	92595	broad.mit.edu	37	16	30567106	30567106	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr16:30567106G>A	ENST00000395091.2	-	3	948	c.633C>T	c.(631-633)ttC>ttT	p.F211F	AC002310.13_ENST00000568114.1_Intron|ZNF764_ENST00000252797.2_Silent_p.F212F			Q96H86	ZN764_HUMAN	zinc finger protein 764	212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7						AAGCGTGGCCGAAGCCCTTGC	0.667000													8	29					0	0	1	0	0
ARFGEF1	10565	broad.mit.edu	37	8	68184169	68184169	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr8:68184169G>A	ENST00000262215.3	-	10	1729	c.1340C>T	c.(1339-1341)tCt>tTt	p.S447F		NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	447					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TAGTTCATGAGACCTAAAATG	0.323000													6	31					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16914278	16914278	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:16914278C>T	ENST00000430580.2	-	10	1395	c.508G>A	c.(508-510)Gag>Aag	p.E170K		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	170	NBPF 1.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTCATCCTCATCTTCGTCA	0.428000													64	387					0	0	1	0	0
ST3GAL2	6483	broad.mit.edu	37	16	70415747	70415747	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr16:70415747C>G	ENST00000393640.4	-	6	3005	c.898G>C	c.(898-900)Ggg>Cgg	p.G300R	ST3GAL2_ENST00000342907.2_Missense_Mutation_p.G300R|RP11-529K1.4_ENST00000566960.1_RNA			Q16842	SIA4B_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	300					amino sugar metabolic process	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)	11		Ovarian(137;0.0694)				CTGTCGGCCCCGAACCCGTAC	0.701000													13	153					0	0	1	0	0
EHD3	30845	broad.mit.edu	37	2	31467291	31467291	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:31467291G>A	ENST00000322054.5	+	2	664	c.379G>A	c.(379-381)Gcc>Acc	p.A127T	EHD3_ENST00000541626.1_Missense_Mutation_p.A127T	NM_014600.2	NP_055415.1	Q9NZN3	EHD3_HUMAN	EH-domain containing 3	127					blood coagulation|endocytic recycling|protein homooligomerization	nucleus|plasma membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|nucleic acid binding|protein binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|skin(3)	33	Acute lymphoblastic leukemia(172;0.155)					GAAACTCAACGCCTTTGGCAA	0.527000													15	40					0	0	1	0	0
GPR21	2844	broad.mit.edu	37	9	125797225	125797225	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr9:125797225G>C	ENST00000373642.1	+	1	420	c.380G>C	c.(379-381)aGa>aCa	p.R127T	RABGAP1_ENST00000493854.1_Intron|RABGAP1_ENST00000373643.5_Intron|RABGAP1_ENST00000373647.4_Intron	NM_005294.1	NP_005285.1	Q99679	GPR21_HUMAN	G protein-coupled receptor 21	127						integral to plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	15						AGCATTGATAGATACATTGCC	0.438000													21	38					0	0	1	0	0
KIF4A	24137	broad.mit.edu	37	X	69563592	69563592	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chrX:69563592G>C	ENST00000374403.3	+	12	1388	c.1306G>C	c.(1306-1308)Gag>Cag	p.E436Q	KIF4A_ENST00000374388.3_Missense_Mutation_p.E436Q	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	436					anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						CAAGCTAGAAGAGCTCAGGCA	0.468000													15	11					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15323276	15323276	+	RNA	SNP	A	A	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr18:15323276A>T	ENST00000455308.2	-	0	572					NR_027417.1																						ATCAACTGCAATTGCATTTGC	0.308000													5	9					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99771602	99771602	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:99771602G>C	ENST00000370185.3	+	7	1825	c.1328G>C	c.(1327-1329)cGa>cCa	p.R443P	LPPR4_ENST00000457765.1_Missense_Mutation_p.R385P|LPPR4_ENST00000370184.1_Missense_Mutation_p.R285P	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		443							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GATTCCGCTCGATCAAAGCAG	0.498000													22	119					0	0	1	0	0
APC2	10297	broad.mit.edu	37	19	1467098	1467098	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr19:1467098G>A	ENST00000535453.1	+	14	5511	c.3798G>A	c.(3796-3798)gaG>gaA	p.E1266E	APC2_ENST00000238483.4_Silent_p.E992E|C19orf25_ENST00000588427.1_Intron|APC2_ENST00000233607.2_Silent_p.E1266E			O95996	APC2_HUMAN	adenomatosis polyposis coli 2	1266	5 X 20 AA approximate repeat of F-X-V-E- X-T-P-X-C-F-S-R-X-S-S-L-S-S-L-S.|Interaction with CTNNB1.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|cervix(1)|kidney(4)|large_intestine(2)|lung(5)|pancreas(1)|skin(2)	18		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTACCGTGGAGAAGCCAGACG	0.672000													7	33					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100334138	100334138	+	RNA	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:100334138G>A	ENST00000542585.1	+	0	287				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGAGGATGACGCCAAACCCCT	0.627000													226	409					0	0	1	0	0
MICAL2	9645	broad.mit.edu	37	11	12265536	12265536	+	Missense_Mutation	SNP	T	T	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:12265536T>G	ENST00000256194.4	+	21	2949	c.2661T>G	c.(2659-2661)aaT>aaG	p.N887K	MICAL2_ENST00000537344.1_Intron|MICAL2_ENST00000527546.1_Intron|MICAL2_ENST00000342902.5_Missense_Mutation_p.N887K|MICAL2_ENST00000379612.3_Intron	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	887						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		CTGTGCAGAATAAACTACTCT	0.478000													61	55					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149430610	149430610	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:149430610C>T	ENST00000255992.10	+	18	2963	c.2564C>T	c.(2563-2565)aCc>aTc	p.T855I	KRBA1_ENST00000485033.2_Missense_Mutation_p.T795I|KRBA1_ENST00000319551.8_Missense_Mutation_p.T795I|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	856										breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGGATGTGGACCCTCCCACGG	0.652000													8	21					0	0	1	0	0
MZB1	51237	broad.mit.edu	37	5	138723467	138723467	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:138723467C>G	ENST00000302125.8	-	4	614	c.557G>C	c.(556-558)aGa>aCa	p.R186T	MZB1_ENST00000412103.2_Missense_Mutation_p.R94T	NM_016459.3	NP_057543.2	Q8WU39	PERP1_HUMAN	marginal zone B and B1 cell-specific protein	186					apoptosis|positive regulation of immunoglobulin biosynthetic process	cytoplasm|endoplasmic reticulum chaperone complex	protein binding										GAGCTCTTCTCTTGTGGCTGA	0.607000													24	122					0	0	1	0	0
TLL2	7093	broad.mit.edu	37	10	98170231	98170231	+	Splice_Site	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr10:98170231G>A	ENST00000357947.3	-	9	1274	c.1048_splice	c.e9-1	p.A350_splice	TLL2_ENST00000469598.1_5'UTR	NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	350	Metalloprotease (By similarity).				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		CTCCCCACACGCTGCACAAGC	0.577000													15	22					0	0	1	0	0
EOMES	8320	broad.mit.edu	37	3	27760382	27760382	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:27760382C>T	ENST00000295743.4	-	4	1364	c.1161G>A	c.(1159-1161)atG>atA	p.M387I	EOMES_ENST00000449599.1_Missense_Mutation_p.M387I|EOMES_ENST00000461503.1_5'UTR|EOMES_ENST00000537516.1_Missense_Mutation_p.M92I			O95936	EOMES_HUMAN	eomesodermin	387					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						GTAAGACTATCATCTGGAAAG	0.368000													7	30					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242277283	242277283	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:242277283C>G	ENST00000442594.2	-	8	1212	c.703G>C	c.(703-705)Gat>Cat	p.D235H	PLD5_ENST00000427495.1_Missense_Mutation_p.D265H|PLD5_ENST00000536534.1_Missense_Mutation_p.D327H	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	327	PLD phosphodiesterase 1.					integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TAGATGGCATCTATGTCAAAA	0.423000													14	73					0	0	1	0	0
PTGR2	145482	broad.mit.edu	37	14	74343732	74343732	+	Nonsense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr14:74343732C>A	ENST00000555661.1	+	5	525	c.380C>A	c.(379-381)tCa>tAa	p.S127*	PTGR2_ENST00000554885.1_Nonsense_Mutation_p.S78*|RP5-1021I20.4_ENST00000553813.1_5'UTR|PTGR2_ENST00000555228.1_Nonsense_Mutation_p.S127*|PTGR2_ENST00000267568.4_Nonsense_Mutation_p.S127*			Q8N8N7	PTGR2_HUMAN	prostaglandin reductase 2	127					prostaglandin metabolic process		15-oxoprostaglandin 13-oxidase activity|zinc ion binding			NS(1)|large_intestine(3)|lung(2)|prostate(1)|skin(2)	9						GGACACCTTTCATATTTTCTT	0.363000													10	34					0.00621372	0.00633967	1	1	0
ABCF3	55324	broad.mit.edu	37	3	183907648	183907648	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:183907648C>G	ENST00000429586.2	+	14	1505	c.1320C>G	c.(1318-1320)ttC>ttG	p.F440L	EIF2B5_ENST00000444495.1_Intron|ABCF3_ENST00000292808.5_Missense_Mutation_p.F434L	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	440							ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGCAGGTTTTCATTGACCGGT	0.577000													37	84					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128341856	128341856	+	Silent	SNP	C	C	T	rs139033746	by1000genomes	TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:128341856C>T	ENST00000389524.4	+	13	1556	c.1503C>T	c.(1501-1503)ctC>ctT	p.L501L	MYO7B_ENST00000428314.1_Silent_p.L501L|MYO7B_ENST00000409816.2_Silent_p.L501L			Q6PIF6	MYO7B_HUMAN	myosin VIIB	501	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TGCTGGCCCTCAAGCCCATGA	0.602000													15	67					0	0	1	0	0
ZFAND2B	130617	broad.mit.edu	37	2	220072627	220072627	+	Nonsense_Mutation	SNP	G	G	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:220072627G>T	ENST00000409594.1	+	4	496	c.301G>T	c.(301-303)Gaa>Taa	p.E101*	ZFAND2B_ENST00000289528.5_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000409412.1_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000444522.2_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000409217.1_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000409336.1_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000409319.1_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000409206.1_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000409097.1_Nonsense_Mutation_p.E101*|ZFAND2B_ENST00000468301.1_3'UTR			Q8WV99	ZFN2B_HUMAN	zinc finger, AN1-type domain 2B	101						endoplasmic reticulum	protein binding|zinc ion binding			endometrium(2)|kidney(4)|lung(4)|upper_aerodigestive_tract(1)	11		Renal(207;0.0915)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAATAAGTGTGAACGCGCTGG	0.522000													21	96					3.62473e-10	3.88181e-10	1	1	0
PHTF2	57157	broad.mit.edu	37	7	77558459	77558459	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:77558459C>T	ENST00000416283.2	+	10	1177	c.1051C>T	c.(1051-1053)Cgc>Tgc	p.R351C	PHTF2_ENST00000275575.7_Missense_Mutation_p.R347C|PHTF2_ENST00000307305.8_Missense_Mutation_p.R347C|PHTF2_ENST00000424760.1_Missense_Mutation_p.R347C|PHTF2_ENST00000454592.1_3'UTR|PHTF2_ENST00000422959.2_Missense_Mutation_p.R351C|PHTF2_ENST00000248550.7_Missense_Mutation_p.R385C	NM_001127357.1|NM_020432.4	NP_001120829.1|NP_065165.3	Q8N3S3	PHTF2_HUMAN	putative homeodomain transcription factor 2	385					regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum|nucleus	DNA binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	19						TTGCAGCTCTCGCTGTTCAAG	0.408000													7	46					0	0	1	0	0
LAMC2	3918	broad.mit.edu	37	1	183201964	183201964	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:183201964C>T	ENST00000264144.4	+	14	2257	c.2192C>T	c.(2191-2193)gCa>gTa	p.A731V	LAMC2_ENST00000493293.1_Missense_Mutation_p.A731V	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	731	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						CTGAGCCTGGCAGAAAGTGAA	0.493000													23	109					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66947161	66947161	+	Silent	SNP	C	C	T	rs111577617		TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr16:66947161C>T	ENST00000299752.4	-	9	1120	c.927G>A	c.(925-927)caG>caA	p.Q309Q	CDH16_ENST00000565796.1_Silent_p.Q309Q|CDH16_ENST00000570262.1_Silent_p.Q229Q|CDH16_ENST00000394055.3_Silent_p.Q309Q|CDH16_ENST00000568632.1_Silent_p.Q212Q	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	309	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CATGGGAATTCTGAGCCCGCA	0.627000													29	100					0	0	1	0	0
HPS1	3257	broad.mit.edu	37	10	100185701	100185701	+	Silent	SNP	A	A	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr10:100185701A>T	ENST00000325103.6	-	12	1262	c.1029T>A	c.(1027-1029)ccT>ccA	p.P343P	HPS1_ENST00000467246.1_5'UTR|HPS1_ENST00000361490.4_Silent_p.P343P	NM_000195.3	NP_000186.2	Q92902	HPS1_HUMAN	Hermansky-Pudlak syndrome 1	343					lysosome organization|response to stimulus|visual perception	cytoplasmic membrane-bounded vesicle|integral to plasma membrane|lysosome|membrane fraction|soluble fraction	protein dimerization activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23		Colorectal(252;0.234)		Epithelial(162;3.87e-12)|all cancers(201;5.63e-10)		CGGAAGGCACAGGGCAGTGGG	0.587000									Hermansky-Pudlak syndrome		OREG0020430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	55	108					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97868994	97868994	+	Silent	SNP	C	C	T	rs140385435		TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:97868994C>T	ENST00000437310.1	+	1	825	c.765C>T	c.(763-765)ctC>ctT	p.L255L		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATGGGCCCCTCGCCTTCATGT	0.413000													11	52					0	0	1	0	0
SETBP1	26040	broad.mit.edu	37	18	42530226	42530226	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr18:42530226G>A	ENST00000282030.5	+	4	1217	c.921G>A	c.(919-921)gaG>gaA	p.E307E		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	307						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCTCTGCTGAGTGCAACGGGC	0.547000									Schinzel-Giedion syndrome				56	67					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126138782	126138782	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:126138782G>A	ENST00000299308.3	+	9	2771	c.2763G>A	c.(2761-2763)gcG>gcA	p.A921A	TMEM132B_ENST00000535886.1_Silent_p.A433A	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	921						integral to membrane		p.A921A(1)		NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACTGCGTGGCGTTTGCCTGGA	0.522000													4	144					0	0	1	0	0
BTBD3	22903	broad.mit.edu	37	20	11899001	11899001	+	Silent	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr20:11899001C>G	ENST00000405977.1	+	2	703	c.78C>G	c.(76-78)tcC>tcG	p.S26S	RP4-742J24.2_ENST00000439529.1_RNA|BTBD3_ENST00000399006.2_5'UTR|BTBD3_ENST00000254977.3_5'UTR|BTBD3_ENST00000378226.2_Silent_p.S26S			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	26										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						AGAACAGGTCCAAGAAAAGCT	0.403000													109	220					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122648679	122648679	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr10:122648679G>A	ENST00000263461.6	+	17	2457	c.2211G>A	c.(2209-2211)ttG>ttA	p.L737L	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	737						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TCTGGGACTTGAAAGGCAGAG	0.338000													25	120					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	75986735	75986735	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:75986735G>A	ENST00000487694.3	+	2	370	c.91G>A	c.(91-93)Ggg>Agg	p.G31R		NM_001128929.2	NP_001122401.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	0	Ig-like C2-type 1.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGGTCATCAGGGGAATGGACA	0.443000													3	31					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113202	209113202	+	Missense_Mutation	SNP	A	A	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:209113202A>G	ENST00000415913.1	-	4	686	c.305T>C	c.(304-306)aTt>aCt	p.I102T	IDH1_ENST00000345146.2_Missense_Mutation_p.I102T|IDH1_ENST00000446179.1_Missense_Mutation_p.I102T			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	102					2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		GCCACCCAGAATATTTCGTAT	0.448000			Mis		gliobastoma								9	73					0	0	1	0	0
B3GNT3	10331	broad.mit.edu	37	19	17922596	17922596	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr19:17922596G>A	ENST00000318683.6	+	3	931	c.784G>A	c.(784-786)Gag>Aag	p.E262K	B3GNT3_ENST00000595387.1_Missense_Mutation_p.E262K	NM_014256.3	NP_055071.2	Q9Y2A9	B3GN3_HUMAN	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	262					protein glycosylation	Golgi membrane|integral to plasma membrane	galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	21						GACTCAGAATGAGCGGTACCC	0.612000													30	65					0	0	1	0	0
SYT6	148281	broad.mit.edu	37	1	114680328	114680328	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:114680328C>T	ENST00000393296.1	-	3	937	c.860G>A	c.(859-861)cGc>cAc	p.R287H	SYT6_ENST00000369547.1_Missense_Mutation_p.R202H			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	287	C2 1.				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGGGTCTTGCGGTGCACCCG	0.547000													4	110					0	0	1	0	0
B4GALT5	9334	broad.mit.edu	37	20	48259055	48259055	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr20:48259055G>A	ENST00000371711.4	-	5	743	c.556C>T	c.(556-558)Ccc>Tcc	p.P186S		NM_004776.3	NP_004767.1	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5	186					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	20			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			TGGAGCATGGGAAGCAGGTGT	0.498000													40	74					0	0	1	0	0
CHCHD3	54927	broad.mit.edu	37	7	132570490	132570490	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:132570490C>T	ENST00000262570.5	-	5	529	c.385G>A	c.(385-387)Gag>Aag	p.E129K	CHCHD3_ENST00000476546.1_5'UTR|CHCHD3_ENST00000448878.1_Missense_Mutation_p.E134K	NM_017812.2	NP_060282.1	Q9NX63	CHCH3_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 3	129					inner mitochondrial membrane organization|mitochondrial fusion	mitochondrial inner membrane	protein complex scaffold			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	7						CGGTCTTTCTCTTCCAGCTGC	0.363000													10	102					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77089948	77089948	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr3:77089948G>A	ENST00000461745.1	+	1	912	c.12G>A	c.(10-12)ctG>ctA	p.L4L	ROBO2_ENST00000487694.3_Intron|ROBO2_ENST00000332191.8_Silent_p.L4L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	4					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		TGAGTCTGCTGATGTTTACAC	0.378000													21	101					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175066664	175066664	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr1:175066664C>G	ENST00000239462.4	+	8	1813	c.1700C>G	c.(1699-1701)tCt>tGt	p.S567C		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	567	Fibronectin type-III 4.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGCTACACCTCTGCTGACGAC	0.592000													13	57					0	0	1	0	0
DNASE1	1773	broad.mit.edu	37	16	3707076	3707076	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr16:3707076C>T	ENST00000246949.5	+	6	3722	c.513C>T	c.(511-513)gaC>gaT	p.D171D	DNASE1_ENST00000407479.1_Silent_p.D171D|DNASE1_ENST00000414110.2_Intron	NM_005223.3	NP_005214.2	P24855	DNAS1_HUMAN	deoxyribonuclease I	171					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity			lung(1)	1		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	CTCTCTATGACGTCTACCTGG	0.647000													13	60					0	0	1	0	0
TRAPPC8	22878	broad.mit.edu	37	18	29453502	29453502	+	Splice_Site	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr18:29453502C>T	ENST00000283351.4	-	14	2289		c.e14-1		TRAPPC8_ENST00000582539.1_Splice_Site	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8						ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GACTTACATTCTGAGAGAAAT	0.353000													4	20					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16437286	16437286	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr9:16437286C>T	ENST00000380672.4	-	6	963	c.906G>A	c.(904-906)gaG>gaA	p.E302E	BNC2_ENST00000545497.1_Silent_p.E207E|BNC2_ENST00000380667.2_Silent_p.E235E|BNC2_ENST00000380666.2_Silent_p.E302E	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding	p.E302E(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GATTGCTGTTCTCTAAGTGAG	0.473000													54	143					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26652621	26652621	+	Silent	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr2:26652621C>G	ENST00000288710.2	+	5	740	c.666C>G	c.(664-666)ctC>ctG	p.L222L		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		GTGAGGAGCTCTATAACATTG	0.483000													16	67					0	0	1	0	0
MRPL11	65003	broad.mit.edu	37	11	66204683	66204683	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:66204683C>T	ENST00000310999.7	-	4	458	c.365G>A	c.(364-366)cGc>cAc	p.R122H	MRPL11_ENST00000524576.1_5'UTR|MRPL11_ENST00000430466.2_Missense_Mutation_p.R96H|MRPL11_ENST00000329819.4_Missense_Mutation_p.R122H	NM_016050.3	NP_057134.1	Q9Y3B7	RM11_HUMAN	mitochondrial ribosomal protein L11	122					translation		structural constituent of ribosome			endometrium(3)|lung(2)|ovary(1)|prostate(1)	7						AGCTTTGATGCGGGCAATCTC	0.562000													35	59					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26902807	26902807	+	Missense_Mutation	SNP	G	G	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:26902807G>T	ENST00000231021.4	-	7	1203	c.1031C>A	c.(1030-1032)aCt>aAt	p.T344N		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	344	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CACTCTTAAAGTATAGAGCAT	0.328000													16	56					6.72482e-11	7.2532e-11	1	1	0
POTEC	388468	broad.mit.edu	37	18	14537814	14537814	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr18:14537814C>T	ENST00000358970.5	-	3	795	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	266										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TTTTTTGATTCAATATCAGCA	0.348000													9	52					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	18					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25310190	25310190	+	RNA	SNP	T	T	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr15:25310190T>C	ENST00000549804.2	+	0	538				SNORD116-6_ENST00000384711.1_RNA|SNHG14_ENST00000551077.1_RNA																							TGATGAGTCCTCCAAAAAAAA	0.483000													4	130					0	0	1	0	0
MRPS16	51021	broad.mit.edu	37	10	75011591	75011591	+	Silent	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr10:75011591G>C	ENST00000372945.3	-	2	414	c.204C>G	c.(202-204)ctC>ctG	p.L68L	MRPS16_ENST00000372940.3_Silent_p.L68L|MRPS16_ENST00000416782.2_Silent_p.L68L|MRPS16_ENST00000479005.1_5'UTR|DNAJC9-AS1_ENST00000440197.2_RNA	NM_016065.3	NP_057149.1	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16	68					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			large_intestine(2)|lung(2)	4	Prostate(51;0.0119)					TGTCTAGGTTGAGGGCAACGA	0.527000													23	161					0	0	1	0	0
TUBBP5	643224	broad.mit.edu	37	9	141070213	141070213	+	RNA	SNP	A	A	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr9:141070213A>G	ENST00000503395.1	+	0	1293																											AGGGCAGCTCAAAATCCAGGA	0.632000													3	32					0	0	1	0	0
TNIP2	79155	broad.mit.edu	37	4	2757762	2757762	+	Silent	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr4:2757762G>A	ENST00000315423.7	-	1	341	c.255C>T	c.(253-255)gcC>gcT	p.A85A	TNIP2_ENST00000510267.1_5'UTR|TNIP2_ENST00000503235.1_Silent_p.A85A	NM_024309.3	NP_077285.3	Q8NFZ5	TNIP2_HUMAN	TNFAIP3 interacting protein 2	85						cytosol	protein binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(6)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GGGCCTCGGCGGCGCCGCCCT	0.751000													5	17					0	0	1	0	0
OR6M1	390261	broad.mit.edu	37	11	123676164	123676164	+	Silent	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:123676164C>T	ENST00000309154.2	-	1	931	c.894G>A	c.(892-894)ttG>ttA	p.L298L		NM_001005325.1	NP_001005325.1	Q8NGM8	OR6M1_HUMAN	olfactory receptor, family 6, subfamily M, member 1	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|prostate(2)|skin(5)|urinary_tract(1)	29		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.028)		CTGTCTCTCTCAACACTTCCT	0.388000													23	114					0	0	1	0	0
TM9SF1	10548	broad.mit.edu	37	14	24679955	24679955	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr14:24679955C>T	ENST00000556387.1	-	4	412	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	CHMP4A_ENST00000347519.6_Missense_Mutation_p.E170K|AL136419.6_ENST00000565988.1_RNA|CHMP4A_ENST00000542700.2_5'UTR|TM9SF1_ENST00000530611.1_Missense_Mutation_p.E127K			O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1	0					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				NS(1)|breast(4)|endometrium(3)|large_intestine(11)|lung(4)|ovary(1)	24				GBM - Glioblastoma multiforme(265;0.0183)		GTCATCAGTTCATCTACCTTG	0.473000													19	48					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160025779	160025779	+	Missense_Mutation	SNP	C	C	G			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:160025779C>G	ENST00000327245.5	-	22	4408	c.3562G>C	c.(3562-3564)Gag>Cag	p.E1188Q		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	1188					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTCCTTACCTCAGAGTTCTGG	0.522000													65	434					0	0	1	0	0
ZNF764	92595	broad.mit.edu	37	16	30567092	30567092	+	Missense_Mutation	SNP	G	G	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr16:30567092G>A	ENST00000395091.2	-	3	962	c.647C>T	c.(646-648)tCc>tTc	p.S216F	AC002310.13_ENST00000568114.1_Intron|ZNF764_ENST00000252797.2_Missense_Mutation_p.S217F			Q96H86	ZN764_HUMAN	zinc finger protein 764	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	7						TTTGCTCAGGGAGGAAGCGTG	0.662000													6	27					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42200423	42200423	+	Missense_Mutation	SNP	C	C	A			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr6:42200423C>A	ENST00000541110.1	-	17	3902	c.3334G>T	c.(3334-3336)Ggc>Tgc	p.G1112C	TRERF1_ENST00000372917.4_Missense_Mutation_p.G1021C|TRERF1_ENST00000354325.2_Missense_Mutation_p.G1009C|TRERF1_ENST00000372922.4_Missense_Mutation_p.G1092C|TRERF1_ENST00000340840.2_Missense_Mutation_p.G1021C			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1092	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			ACCTACTTGCCACACTCCTTG	0.577000													3	18					0.150653	0.152676	1	1	0
SLCO6A1	133482	broad.mit.edu	37	5	101735275	101735275	+	Missense_Mutation	SNP	C	C	T			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr5:101735275C>T	ENST00000506729.1	-	10	1969	c.1798G>A	c.(1798-1800)Gtc>Atc	p.V600I	SLCO6A1_ENST00000389019.3_Missense_Mutation_p.V538I|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.V600I|SLCO6A1_ENST00000379810.1_Missense_Mutation_p.V347I|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.V347I			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	600						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		ATGGCCAAGACGATTGGTACA	0.303000													14	80					0	0	1	0	0
CLIP1	6249	broad.mit.edu	37	12	122826036	122826036	+	Missense_Mutation	SNP	G	G	C			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr12:122826036G>C	ENST00000358808.2	-	10	1836	c.1682C>G	c.(1681-1683)tCt>tGt	p.S561C	CLIP1_ENST00000545889.1_Missense_Mutation_p.S262C|CLIP1_ENST00000540338.1_Missense_Mutation_p.S572C|CLIP1_ENST00000537178.1_Missense_Mutation_p.S526C|CLIP1_ENST00000361654.4_Missense_Mutation_p.S526C|CLIP1_ENST00000302528.7_Missense_Mutation_p.S561C	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	572					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CTCCTTCAGAGAAGTTATTTC	0.458000													65	339					0	0	1	0	0
TNS3	64759	broad.mit.edu	37	7	47323419	47323432	+	Frame_Shift_Del	DEL	TGAGGGACTCCATC	TGAGGGACTCCATC	-			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:47323419_47323432delTGAGGGACTCCATC	ENST00000398879.1	-	28	4326_4339	c.3960_3973delGATGGAGTCCCTCA	c.(3958-3975)gaccfs	p.EMESLT1320fs	TNS3_ENST00000355730.3_Frame_Shift_Del_p.EMESLT1080fs|TNS3_ENST00000311160.9_Frame_Shift_Del_p.EMESLT1320fs			Q68CZ2	TENS3_HUMAN	tensin 3	1320						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						TGGTGGCCGGTGAGGGACTCCATCTCCACAGAGT	0.556													36	65	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142481923	142481925	+	RNA	DEL	CAA	CAA	-			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr7:142481923_142481925delCAA	ENST00000603901.1	+	0	591					NR_001296.3																						GTGATTAGACCAACCCTTCCCAT	0.537													9	43	---	---	---	---					
LCN15	389812	broad.mit.edu	37	9	139657833	139657833	+	Frame_Shift_Del	DEL	G	G	-			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr9:139657833delG	ENST00000316144.5	-	4	418	c.394delC	c.(394-396)tcfs	p.L132fs	LCN15_ENST00000482511.1_5'UTR	NM_203347.1	NP_976222.1	Q6UWW0	LCN15_HUMAN	lipocalin 15	132					lipid metabolic process	extracellular region	binding|transporter activity			endometrium(1)|lung(1)	2						ATGGTGCTGAGGGCCCCCTCC	0.652													16	69	---	---	---	---					
MALAT1	378938	broad.mit.edu	37	11	65268315	65268317	+	RNA	DEL	GGG	GGG	-			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chr11:65268315_65268317delGGG	ENST00000534336.1	+	0	3083_3085					NR_002819.2																						CTAATATAATGGGGGAGTTTCGT	0.399													19	26	---	---	---	---					
XIST	7503	broad.mit.edu	37	X	73069752	73069752	+	RNA	DEL	G	G	-			TCGA-95-8494-01A-11D-2323-08	TCGA-95-8494-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	db6db3f7-ac97-46eb-a799-efc77209a1e3	a4d83fa4-8a2d-4f51-a039-3e0b2f3e42e3	g.chrX:73069752delG	ENST00000429829.1	-	0	2836					NR_001564.2																						ggctAGACTAGGGGTTTGCTG	0.582													9	4	---	---	---	---